FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Gartrell, CA Newman, JK Anderton, GL AF Gartrell, Chad A. Newman, John K. Anderton, Gary L. TI Performance Measurements of Pavement Matting Systems by Full-Scale Testing over Differing Soil Strengths SO JOURNAL OF MATERIALS IN CIVIL ENGINEERING LA English DT Article AB The focus of this work was to evaluate the use of commercially available matting systems to sustain C-130 and C-17 transport aircraft loads over soil bases having different California bearing ratio (CBR) ranges. Test sections were constructed using three range of CBR: high (CBR=40-50), medium (CBR=8-10), and low (CBR=5-6). Testing began with the C-130 load cart and six different matting systems. The C-130 was the lesser of the two aircraft loads examined and this initial testing was used as an "elimination round" for the various matting systems chosen. Matting systems deemed suitable for the C-130 were further tested under the C-17 load cart. Systems were evaluated based on logistical and assembly requirements, mat damage sustained during traffic, and accumulated deformation of the mats and soil during traffic. The latter are shown in line plots of passes versus plastic rut formation. Summary information on each matting system tested and the test sections themselves is presented. Conclusions on the matting systems tested and their application are discussed. C1 [Gartrell, Chad A.; Newman, John K.; Anderton, Gary L.] USA, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. RP Gartrell, CA (reprint author), USA, Ctr Res Dev & Engn, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM chad.a.gartrell@erdc.usace.army.mil; john.k.newman@erdc.usace.army.mil; gary.l.anderton@erdc.usace.army.mil NR 6 TC 6 Z9 8 U1 1 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0899-1561 J9 J MATER CIVIL ENG JI J. Mater. Civ. Eng. PD OCT PY 2009 VL 21 IS 10 BP 561 EP 568 DI 10.1061/(ASCE)0899-1561(2009)21:10(561) PG 8 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA 494WG UT WOS:000269849500005 ER PT J AU Cole, MW Podpirka, A Ramanathan, S AF Cole, Melanie W. Podpirka, Adrian Ramanathan, Shriram TI A post-growth processing methodology to achieve barium strontium titanate thin films with low dielectric loss and high tunability for reconfigurable tunable devices SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID LEAKAGE CURRENTS; MICROWAVE; DEPENDENCE AB Ba(0.60)Sr(0.40)TiO(3) (BST) thin films, grown via RF-sputtering and the metalorganic solution deposition (MOSD) techniques, were post-growth annealed via conventional thermal annealing (CTA) and UV-photon irradiation annealing. With respect to the conventional thermal annealed films the UV-photon irradiation annealed films possessed improved structural properties and dielectric response. The optimization of the UV-photon irradiation annealing process parameters (using RF-sputtered BST films) was achieved via a detailed set of iso-thermal/chronal annealing experiments. The optimized UV-process parameters, applied to MOSD synthesized BST films revealed further enhanced dielectric response, i.e., 23% reduction in tan delta with sustained tunability of 42%. The improvements in the material properties of the UV-photon irradiation annealed BST thin films are attributed to stoichiometry and structural changes enabled through the UV-photon irradiation annealing process. C1 [Cole, Melanie W.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Podpirka, Adrian; Ramanathan, Shriram] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA. RP Cole, MW (reprint author), USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM mcole@arl.army.mil OI Podpirka, Adrian/0000-0002-4000-989X NR 26 TC 8 Z9 8 U1 0 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD OCT PY 2009 VL 44 IS 19 BP 5332 EP 5338 DI 10.1007/s10853-009-3538-0 PG 7 WC Materials Science, Multidisciplinary SC Materials Science GA 485JK UT WOS:000269117000032 ER PT J AU Weiss, CV Okatan, MB Alpay, SP Cole, MW Ngo, E Toonen, RC AF Weiss, C. V. Okatan, M. B. Alpay, S. P. Cole, M. W. Ngo, E. Toonen, R. C. TI Compositionally graded ferroelectric multilayers for frequency agile tunable devices SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID BARIUM STRONTIUM-TITANATE; PULSED-LASER DEPOSITION; (BA1-XSRX)TIO3 THIN-FILMS; DIELECTRIC-PROPERTIES; PBZR0.2TI0.8O3 FILMS; MICROWAVE DEVICES; INTERNAL-STRESSES; EPITAXIAL-GROWTH; PHASE-DIAGRAMS; TUNABILITY AB Recently, there has been significant interest toward the development of tunable dielectric materials for voltage-controlled, frequency-agile phase shifters and filters operating in the microwave regime. The fundamental challenge in designing materials systems for such tunable devices is the simultaneous requirement of high dielectric tunability (> 40%) over a large temperature interval (-10 A degrees C to +90 A degrees C) coupled with low dielectric losses (between 3.0 dB and 4.0 dB in operational bandwidths ranging from several hundred MHz up to 30 or more GHz). We show that a high- and temperature-insensitive tunability can be realized in compositionally graded ferroelectrics and provide a brief review of the results of experimental and theoretical studies on the dielectric properties of Barium Strontium Titanate (Ba1-x Sr (x) TiO3 or BST) multilayer heterostructures. Theoretically, we discuss the role of thermal stresses on the dielectric properties using a non-linear thermodynamic model coupled with basic electrostatic considerations to describe the interlayer interactions between the ferroelectric layers. We show that the thermal strains arising from the thermal expansion coefficient mismatch between the multilayered film and the substrate may have a significant effect on the dielectric permittivity and tunability of BST multilayers. Experimentally, compositionally graded BST multilayers (5 mol% MgO doped and undoped) were grown via metallo-organic solution deposition (MOSD) on Pt-Si substrates and electrically characterized. Optimum conditions were found to exist in BST multilayers consisting of three distinct layers of similar to 220 nm nominal thickness with compositions corresponding to Ba0.60Sr0.40TiO3 (BST 60/40), BST 75/25, and BST 90/10. At room temperature, the BST heterostructure has a small-signal dielectric permittivity of 360 with a dissipation factor of 0.012 and a dielectric tunability of 65% at 444 kV/cm. These properties exhibit minimal dispersion as a function of temperature ranging from 90 A degrees C to -10 A degrees C. Our results also show that MgO doping improves dielectric loss (tan delta = 0.008), but results in a moderate dielectric tunability of 29% at 444 kV/cm. Electrical measurements at microwave frequencies display a decrease in the dielectric permittivity and tunability for both undoped and MgO-doped BST multilayers. At 10 GHz, the dielectric response, tunability, and the loss characteristics for graded undoped BST are 261, 25% (at 1,778 kV/cm), and 0.078, respectively, and 189 and 15% (at 1,778 kV/cm), and 0.039, respectively, for the MgO-doped graded BST. C1 [Weiss, C. V.; Okatan, M. B.; Alpay, S. P.] Univ Connecticut, Mat Sci & Engn Program, Storrs, CT 06269 USA. [Cole, M. W.; Ngo, E.; Toonen, R. C.] USA, Res Lab, Act Mat Res Grp, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Weiss, C. V.; Okatan, M. B.; Alpay, S. P.] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA. RP Alpay, SP (reprint author), Univ Connecticut, Mat Sci & Engn Program, Storrs, CT 06269 USA. EM p.alpay@ims.uconn.edu; mcole@arl.army.mil RI Alpay, Pamir/E-2666-2013; Okatan, M. Baris/E-1913-2016 OI Okatan, M. Baris/0000-0002-9421-7846 FU U. S. Army Research Office [W911NF-05-1-0528, W911NF-08-C-0124] FX This study at UConn was supported by the U. S. Army Research Office through Grants W911NF-05-1-0528 and W911NF-08-C-0124. The authors would like to thank C. Hubbard for the XRD measurements, and S. Hirsch for the SEM analysis. NR 54 TC 18 Z9 19 U1 4 U2 39 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 EI 1573-4803 J9 J MATER SCI JI J. Mater. Sci. PD OCT PY 2009 VL 44 IS 19 SI SI BP 5364 EP 5374 DI 10.1007/s10853-009-3514-8 PG 11 WC Materials Science, Multidisciplinary SC Materials Science GA 485JK UT WOS:000269117000036 ER PT J AU Rothwell, SW Sawyer, E Dorsey, J Flournoy, WS Settle, T Simpson, D Cadd, G Janmey, P White, C Szabo, KA AF Rothwell, Stephen W. Sawyer, Evelyn Dorsey, Jennifer Flournoy, William S. Settle, Timothy Simpson, David Cadd, Gary Janmey, Paul White, Charles Szabo, Kathleen A. TI Wound healing and the immune response in swine treated with a hemostatic bandage composed of salmon thrombin and fibrinogen SO JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE LA English DT Article ID BOVINE THROMBIN; ANIMAL-MODEL; RITUXIMAB; INJURY; PURIFICATION; INHIBITOR; SEALANTS AB We investigated the inflammatory response in pigs exposed to salmon fibrinogen/thrombin dressings. Animals were exposed to the material in 3 ways: (a) thrombin and fibrinogen were injected intravenously, (b) dual full-thickness skin lesions were surgically created on the dorsal aspect of the swine and treated with the fibrinogen/thrombin bandage and a commercial bandage or (c) a fibrinogen/thrombin bandage was inserted through an abdominal incision into the peritoneal cavity. Blood was collected twice weekly and animals were sacrificed at 7, 10 or 28 days. Animals in the 28-day dermal lesion group were given an injection of salmon fibrinogen/thrombin at the 10 day point to simulate a second bandage application. The immune response manifested itself as induction of germinal centers in mesenteric lymph nodes and in the white pulp of the spleen. Examination of the histology of the skin and organs showed a cellular inflammatory response with granulation tissue and signs of edema that resolved by the 28-day stage. Antibodies reactive to salmon and human thrombin and fibrinogen were detected, but fibrinogen levels and coagulation processes were not affected. In conclusion, animals treated with salmon fibrinogen/thrombin bandages demonstrated a smooth recovery course in terms of both tissue healing and the immune response without adverse effects from the exposure to the fish proteins. C1 [Rothwell, Stephen W.] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA. [Sawyer, Evelyn] Sea Run Holdings, Freeport, ME USA. [Dorsey, Jennifer] Walter Reed Army Inst Res, Div Mil Casualty Res, Silver Spring, MD 21910 USA. [Flournoy, William S.; Settle, Timothy] Walter Reed Army Inst Res, Div Vet Med, Silver Spring, MD 21910 USA. [Simpson, David; Cadd, Gary] Nanomatrix Inc, Baton Rouge, LA USA. [Janmey, Paul] Univ Penn, Inst Med & Engn, Philadelphia, PA 19104 USA. [White, Charles] Walter Reed Army Inst Res, Div Biometr, Silver Spring, MD 21910 USA. [Szabo, Kathleen A.] Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD 21910 USA. RP Rothwell, SW (reprint author), Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM srothwell@usuhs.mil FU Office of Naval Research, Arlington, VA [N0001406MP20010]; The Uniformed Services University of the Health Sciences, Bethesda, MD [R070TF]; US Army, Military Research and Materiel Command FX The authors are grateful to the staff of the Surgery Department, Division of Veterinary Medicine, Walter Reed Army Institute of Medicine for their expert care of the animals in all phases of the experiments. This research project was supported by funding from the Office of Naval Research, Arlington, VA ( Project No.: N0001406MP20010), The Uniformed Services University of the Health Sciences, Bethesda, MD ( R070TF) and by the US Army, Military Research and Materiel Command, Ft. Detrick, MD. NR 26 TC 15 Z9 16 U1 0 U2 3 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0957-4530 J9 J MATER SCI-MATER M JI J. Mater. Sci.-Mater. Med. PD OCT PY 2009 VL 20 IS 10 BP 2155 EP 2166 DI 10.1007/s10856-009-3769-2 PG 12 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA 499EU UT WOS:000270201100020 PM 19449202 ER PT J AU Kovalskiy, A Cech, J Vlcek, M Waits, CM Dubey, M Heffner, WR Jain, H AF Kovalskiy, Andriy Cech, Jiri Vlcek, Miroslav Waits, Christopher M. Dubey, Madan Heffner, William R. Jain, Himanshu TI Chalcogenide glass e-beam and photoresists for ultrathin grayscale patterning SO JOURNAL OF MICRO-NANOLITHOGRAPHY MEMS AND MOEMS LA English DT Article DE chalcogenide glass (ChG); photoresist; gray scale; lithography; Fresnel lenses; dry etching; wet etching ID GRAY-SCALE LITHOGRAPHY; AMORPHOUS THIN-FILMS; AS-S; VITREOUS SEMICONDUCTORS; PHOTOSTRUCTURAL CHANGES; ALKALINE-SOLUTIONS; PHOTONIC CRYSTALS; OPTICAL-ELEMENTS; WAVE-GUIDE; LAYERS AB The advantages and applications of chalcogenide glass (ChG) thin film photoresists for grayscale lithography are demonstrated. It is shown that the ChG films can be used to make ultrathin (similar to 600 nm), high-resolution grayscale patterns, which can find their application, for example, in IR optics. Unlike polymer photoresists, the IR transparent ChG patterns can be useful as such on the surface or can be used to transfer the etched pattern into silicon or other substrates. Even if the ChG is used as an etch mask for the silicon substrate, its greater hardness can achieve a greater etch selectivity than that obtained with organic photoresists. The suitability of ChG photoresists is demonstrated with inexpensive and reliable fabrication of ultrathin Fresnel lenses that are transparent in the visible as well as in the IR region. The optical functionality of the Fresnel lenses is confirmed. Application of silver photodissolution in grayscale lithography for microelectromechanical systems (MEMS) applications is also shown. A substrate to ChG/silver thickness etching ratio of similar to 10 is obtained for the transfer of patterns into silicon using reactive ion etching (RIE), more than a fivefold increase compared to traditional polymer photoresist. (C) 2009 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3273966] C1 [Kovalskiy, Andriy; Cech, Jiri] Lehigh Univ, Ctr Opt Technol, Bethlehem, PA 18015 USA. [Vlcek, Miroslav] Univ Pardubice, Fac Chem Technol, Pardubice 53210, Czech Republic. [Waits, Christopher M.; Dubey, Madan] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Heffner, William R.; Jain, Himanshu] Lehigh Univ, Int Mat Inst New Funct Glass, Bethlehem, PA 18015 USA. RP Kovalskiy, A (reprint author), Lehigh Univ, Ctr Opt Technol, 5 E Packer Ave, Bethlehem, PA 18015 USA. EM ank304@lehigh.edu RI Kovalskiy, Andriy/A-8566-2008; Cech, Jiri/A-2506-2009; VLCEK, Miroslav/G-1673-2015 OI Kovalskiy, Andriy/0000-0002-5014-2467; Cech, Jiri/0000-0002-3372-545X; FU Center for Optical Technology (Lehigh University); Lehigh University-Army Research Lab (ARL) collaborative research program; National Science Foundation [DMR 00-74624, DMR 03-12081, DMR 04-09588]; Pennsylvania Department of Community and Economic Development through the Ben Franklin Technology Development Authority; Czech Ministry of Education, Youth, and Sports [0021627501] FX Separate parts of this work were supported by the Center for Optical Technology (Lehigh University), a Lehigh University-Army Research Lab (ARL) collaborative research program; the National Science Foundation (DMR 00-74624, and DMR 03-12081, DMR 04-09588); and the Pennsylvania Department of Community and Economic Development through the Ben Franklin Technology Development Authority. M. V. thanks the Czech Ministry of Education, Youth, and Sports for support under Grant No. 0021627501. NR 45 TC 21 Z9 21 U1 2 U2 10 PU SPIE-SOC PHOTOPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 1537-1646 J9 J MICRO-NANOLITH MEM JI J. Micro-Nanolithogr. MEMS MOEMS PD OCT-DEC PY 2009 VL 8 IS 4 AR 043012 DI 10.1117/1.3273966 PG 11 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Optics SC Engineering; Science & Technology - Other Topics; Materials Science; Optics GA 552DE UT WOS:000274266800020 ER PT J AU Maass, JR AF Maass, John R. TI "Too Grievous for a People to Bear": Impressment and Conscription in Revolutionary North Carolina SO JOURNAL OF MILITARY HISTORY LA English DT Article AB Waging the War of American Independence (1775-83) required massive numbers of troops, weapons, and supplies in quantities most states could not readily provide. Meeting these needs were persistent challenges for the nascent state governments, all of which lacked a financial foundation, manufacturing base, and logistical network to sustain a concerted war effort. North Carolina was particularly beset by these challenges, which led state officials to adopt two of the most burdensome intrusions into the wartime routines of Carolinians: impressment and conscription. Both of these expedients produced antipathy and resistance to Patriot authorities, undermined support for the new state, and added to the disorders within the state during most of the war years. C1 USA, Ctr Mil Hist, Washington, DC 20310 USA. RP Maass, JR (reprint author), USA, Ctr Mil Hist, Washington, DC 20310 USA. NR 38 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2009 VL 73 IS 4 BP 1091 EP 1115 PG 25 WC History SC History GA 503TP UT WOS:000270563400002 ER PT J AU Rafuse, ES AF Rafuse, Ethan S. TI The Making of Peace: Rulers, States, and the Aftermath of War. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Rafuse, Ethan S.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Rafuse, ES (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2009 VL 73 IS 4 BP 1298 EP 1299 PG 2 WC History SC History GA 503TP UT WOS:000270563400015 ER PT J AU Stentiford, BM AF Stentiford, Barry M. TI A Rabble in Arms: Massachusetts Towns and Militiamen during King Philip's War. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Stentiford, Barry M.] Sch Adv Mil Studies, Ft Leavenworth, KS USA. RP Stentiford, BM (reprint author), Sch Adv Mil Studies, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2009 VL 73 IS 4 BP 1320 EP 1322 PG 3 WC History SC History GA 503TP UT WOS:000270563400028 ER PT J AU Bourque, SA AF Bourque, Stephen A. TI Iraq's Armed Forces: An Analytical History SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Bourque, Stephen A.] Sch Adv Mil Studies, Ft Leavenworth, KS USA. RP Bourque, SA (reprint author), Sch Adv Mil Studies, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2009 VL 73 IS 4 BP 1365 EP 1366 PG 2 WC History SC History GA 503TP UT WOS:000270563400060 ER PT J AU House, JM AF House, Jonathan M. TI The United States and the Making of Modern Greece: History and Power, 1950-1974 SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [House, Jonathan M.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. RP House, JM (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2009 VL 73 IS 4 BP 1383 EP 1384 PG 2 WC History SC History GA 503TP UT WOS:000270563400072 ER PT J AU Hartings, JA Watanabe, T Dreier, JP Major, S Vendelbo, L Fabricius, M AF Hartings, Jed A. Watanabe, Tomas Dreier, Jens P. Major, Sebastian Vendelbo, Leif Fabricius, Martin TI Recovery of Slow Potentials in AC-Coupled Electrocorticography: Application to Spreading Depolarizations in Rat and Human Cerebral Cortex SO JOURNAL OF NEUROPHYSIOLOGY LA English DT Article ID CORTICAL DEPRESSION; FOCAL ISCHEMIA; HUMAN BRAIN; EEG; INVERSE; SHIFTS; K+ AB Hartings JA, Watanabe T, Dreier JP, Major S, Vendelbo L, Fabricius M. Recovery of slow potentials in AC-coupled electrocorticography: application to spreading depolarizations in rat and human cerebral cortex. J Neurophysiol 102: 2563-2575, 2009. First published June 3, 2009; doi:10.1152/jn.00345.2009. Cortical spreading depolarizations ( spreading depressions and peri-infarct depolarizations) are a pathology intrinsic to acute brain injury, generating large negative extracellular slow potential changes (SPCs) that, lasting on the order of minutes, are studied with DC-coupled recordings in animals. The spreading SPCs of depolarization waves are observed in human cortex with AC-coupled electrocorticography (ECoG), although SPC morphology is distorted by the high-pass filter stage of the amplifiers. Here, we present a signal processing method to reverse these distortions and recover approximate full-band waveforms from AC-coupled recordings. We constructed digital filters that reproduced the phase and amplitude distortions introduced by specific AC-coupled amplifiers and, based on this characterization, derived digital inverse filters to remove these distortions from ECoG recordings. Performance of the inverse filter was validated by its ability to recover both simulated and real low-frequency input test signals. The inverse filter was then applied to AC-coupled ECoG recordings from five patients who underwent invasive monitoring after aneurysmal subarachnoid hemorrhage. For 117 SPCs, the inverse filter recovered full-band waveforms with morphologic characteristics typical of the negative DC shifts recorded in animals. Compared with those recorded in the rat cortex with the same analog and digital methods, the negative DC shifts of human depolarizations had significantly greater durations (1:47 vs. 0:45 min:sec) and peak-to-peak amplitudes (10.1 vs. 4.2 mV). The inverse filter thus permits the study of spreading depolarizations in humans, using the same assessment of full-band DC potentials as that in animals, and suggests a particular solution for recovery of biosignals recorded with frequency-limited amplifiers. C1 [Hartings, Jed A.] Walter Reed Army Med Ctr, Div Psychiat & Neurosci, Washington, DC USA. [Watanabe, Tomas] USN, Med Res Ctr, Undersea Med Dept, Silver Spring, MD USA. [Dreier, Jens P.; Major, Sebastian] Charite, Ctr Stroke Res, D-13353 Berlin, Germany. [Vendelbo, Leif; Fabricius, Martin] Glostrup Cty Hosp, Dept Clin Neurophysiol, Copenhagen, Denmark. RP Hartings, JA (reprint author), Univ Cincinnati, Dept Neurosurg, 260 Stetson St,Suite 2200, Cincinnati, OH 45219 USA. EM jed.hartings@uc.edu OI Dreier, Jens/0000-0001-7459-2828; Major, Sebastian/0000-0003-0970-1308 FU U.S. Department of Defense; German Research Foundation [SFB Tr3 D10, DR 323/3-1]; Novo Nordisk Foundation FX This work was funded by U.S. Department of Defense grants to J. A. Hartings and T. Watanabe, German Research Foundation Grants SFB Tr3 D10 and DR 323/3-1 to J. Dreier, and a Novo Nordisk Foundation grant to M. Fabricius. The views of the authors do not purport or reflect the position of the Department of the Army, Department of the Navy, or the Department of Defense (para. 4-3, AR 360-5). NR 40 TC 15 Z9 15 U1 0 U2 2 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-3077 EI 1522-1598 J9 J NEUROPHYSIOL JI J. Neurophysiol. PD OCT PY 2009 VL 102 IS 4 BP 2563 EP 2575 DI 10.1152/jn.00345.2009 PG 13 WC Neurosciences; Physiology SC Neurosciences & Neurology; Physiology GA 508LG UT WOS:000270932000047 PM 19494192 ER PT J AU Patrician, PA Brosch, LR AF Patrician, Patricia A. Brosch, Laura R. TI Medication Error Reporting and the Work Environment in a Military Setting SO JOURNAL OF NURSING CARE QUALITY LA English DT Article DE medication error reporting; medication errors; nurse staffing; nursing work environment ID ADVERSE DRUG EVENTS; ADMINISTRATION ERRORS; HOSPITALIZED-PATIENTS; PATIENT OUTCOMES; INTENSIVE-CARE; NURSES; COSTS; PERCEPTIONS; ASSOCIATION; MORTALITY AB This study examined nurses' reasons for medication errors, reasons for not reporting errors, and perceived unit-reporting practices. It compared nurses' anonymous reports of medication errors with those from institutional reporting mechanisms. Qualities of the work environment, staffing, and workload were evaluated to determine associations with perceived error-reporting practices. The study findings have immediate applicability as a baseline for system improvements. C1 [Patrician, Patricia A.] Univ Alabama, Sch Nursing, Birmingham, AL 35294 USA. [Brosch, Laura R.] USA, Med Res & Mat Command, Off Res Protect, Ft Detrick, MD USA. RP Patrician, PA (reprint author), Univ Alabama, Sch Nursing, NB 324,1530 3rd Ave S, Birmingham, AL 35294 USA. EM ppatrici@uab.edu FU TriService Nursing Research Program [N01-105]; Uniformed Services University of the Health Sciences (USUHS) FX This study was funded by the TriService Nursing Research Program (Grant N01-105), in sponsorship with the Uniformed Services University of the Health Sciences (USUHS); however, the information or content and conclusions do not necessarily represent the official position or policy of nor should any official endorsement be inferred by the TriService Nursing Research Program, USUHS, the Department of Defense, or the US Government. NR 33 TC 6 Z9 7 U1 4 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1057-3631 J9 J NURS CARE QUAL JI J. Nurs. Care Qual. PD OCT-DEC PY 2009 VL 24 IS 4 BP 277 EP 286 PG 10 WC Nursing SC Nursing GA 497GX UT WOS:000270047500003 PM 19584755 ER PT J AU Joseph, M Maresh, CM McCarthy, MB Kraemer, WJ Ledgard, F Arciero, CL Anderson, JM Nindl, BC Mazzocca, AD AF Joseph, Michael Maresh, Carl M. McCarthy, Mary Beth Kraemer, William J. Ledgard, Felicia Arciero, Cristina L. Anderson, Jeffrey M. Nindl, Bradley C. Mazzocca, Augustus D. TI Histological and Molecular Analysis of the Biceps Tendon Long Head Post-Tenotomy SO JOURNAL OF ORTHOPAEDIC RESEARCH LA English DT Article DE tendinopathy; biceps; tenotomy; histology; extracellular matrix ID GROWTH-FACTOR-I; HUMAN ACHILLES-TENDON; ROTATOR CUFF TENDONS; MATRIX-METALLOPROTEINASE; GENE-EXPRESSION; PATELLAR TENDINOSIS; MESSENGER-RNA; TENDINOPATHY; TISSUE; COLLAGEN AB Tendinopathy is a vexing clinical problem as its onset and development is often asymptomatic and unrecognized until tendon rupture. While extensively studied in the rotator cuff, Achilles, and patellar tendons, no study to date has examined the histological and molecular characteristics of the tendinopathic biceps long-head (LHB). The anatomy of the LHB is unique in that it comprises intra- and extra-articular portions, each exposed to differing loading patterns. Eleven LHBs post-tenotomy were sectioned, fixed in formalin, and stained (H & E; Alcian Blue), and gross structural organization of collagen measured using polarized light microscopy. Protein expression of intra- and extra-articular portions of the tenotomized biceps for IGF-I, collagen III, and MMP-1, -2, -3, and -13 was determined with Western blot analyses. The intra-articular LHB exhibited significantly greater histological evidence of tendinopathy inclusive of increased proteoglycan (p < 0.05) and decreased organization as measured by polarized light microscopy (p < 0.01). The intra-articular LHB also had significantly increased expression of collagen type III (p < 0.01) and of MMP-1 and 3 (p < 0.01, p < 0.05 respectively). No significant differences were found for IGF-I or for MMP-2 and -13. The intra-articular LHB exhibited histological characteristics of tendinopathy. Protein expression of the intra-articular LHB did not universally display signs of tendinopathy in comparison to the extra-articular portion of the tendon. (C) 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27:1379-1385, 2009 C1 [Joseph, Michael; Maresh, Carl M.; Kraemer, William J.; Anderson, Jeffrey M.] Univ Connecticut, Dept Kinesiol, Storrs, CT 06269 USA. [McCarthy, Mary Beth; Ledgard, Felicia; Arciero, Cristina L.; Mazzocca, Augustus D.] Univ Connecticut, Dept Orthoped Surg, Human Soft Tissue Lab, Farmington, CT USA. [Nindl, Bradley C.] USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Joseph, M (reprint author), Univ Connecticut, Dept Kinesiol, Storrs, CT 06269 USA. EM mickpt@sbcglobal.net NR 47 TC 23 Z9 23 U1 1 U2 1 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0736-0266 J9 J ORTHOP RES JI J. Orthop. Res. PD OCT PY 2009 VL 27 IS 10 BP 1379 EP 1385 DI 10.1002/jor.20868 PG 7 WC Orthopedics SC Orthopedics GA 498NJ UT WOS:000270147600018 PM 19340876 ER PT J AU Perrie, W Resio, DT AF Perrie, William Resio, Donald T. TI A Two-Scale Approximation for Efficient Representation of Nonlinear Energy Transfers in a Wind Wave Spectrum. Part II: Application to Observed Wave Spectra SO JOURNAL OF PHYSICAL OCEANOGRAPHY LA English DT Article ID DIRECTIONAL SPECTRA; GENERATED WAVES AB In Part I of this series, a new method for estimating nonlinear transfer rates in wind waves, based on a two-scale approximation (TSA) to the full Boltzmann integral (FBI) for quadruplet wave-wave interactions, was presented, and this new method was tested for idealized spectral data. Here, the focus is on comparisons of the TSA and the discrete interaction approximation (DIA) with the FBI for observed wave spectra from field measurements. Observed wave spectra are taken from a wave gauge array in Currituck Sound and a directional waverider off the coast near the Field Research Facility at Duck, North Carolina. Results show that the TSA compares much more favorably to the FBI than does the DIA, even for cases in which the parametric component of the formulation does not capture the spectral energy distribution very well. These results remain valid for the TSA estimates when the FBI results are significantly affected by the directional distribution of energy. It is also shown that although nonlinear transfers are substantially weaker in swell portions of the spectrum these interactions contribute significantly to the spectral evolution and net energy balance in long-distance swell propagation. C1 [Perrie, William] Fisheries & Oceans Canada, Bedford Inst Oceanog, Dartmouth, NS B2Y 4A2, Canada. [Resio, Donald T.] Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS USA. RP Perrie, W (reprint author), Fisheries & Oceans Canada, Bedford Inst Oceanog, 1 Challenger Dr, Dartmouth, NS B2Y 4A2, Canada. EM perriew@dfo-mpo.gc.ca FU U. S. Army Corps of Engineers MORPHOS program; Canadian Panel on Energy Research and Development; National Oceanographic and Atmospheric Administration via the Southeast University Research Association Coastal Ocean Observing and Prediction (SCOOP) program FX Support for this research comes from the U. S. Army Corps of Engineers MORPHOS program, Canadian Panel on Energy Research and Development (PERD-Offshore Environmental Factors Program), and the National Oceanographic and Atmospheric Administration via the Southeast University Research Association Coastal Ocean Observing and Prediction (SCOOP) program. The authors also acknowledge the Office, Chief of Engineers, U. S. Army Corps of Engineers, for permission to publish this paper. NR 16 TC 3 Z9 3 U1 0 U2 4 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0022-3670 EI 1520-0485 J9 J PHYS OCEANOGR JI J. Phys. Oceanogr. PD OCT PY 2009 VL 39 IS 10 BP 2451 EP 2476 DI 10.1175/2009JPO3947.1 PG 26 WC Oceanography SC Oceanography GA 507KH UT WOS:000270851500005 ER PT J AU Kauvar, DS Wade, CE Baer, DG AF Kauvar, David S. Wade, Charles E. Baer, David G. TI Burn Hazards of the Deployed Environment in Wartime: Epidemiology of Noncombat Burns from Ongoing United States Military Operations SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Article ID ENDURING FREEDOM; IRAQI FREEDOM; COMBAT BURNS; INJURY; MORTALITY AB BACKGROUND: Service in the deployed military environment carries risks for accidental (noncombat-related) burns. Examining these risks can assist in the development of military burn prevention measures. This study endeavored to examine noncombat burn epidemiology in the context of similar civilian data. STUDY DESIGN: We performed a retrospective cohort study of consecutive casualties evacuated from operational military theaters in Iraq and Afghanistan to the sole tertiary military burn center in the US. Military data were compared with database samples of the US population from the American Burn Association and the Centers for Disease Control and Prevention. RESULTS: The main causes of the 180 noncombat burns seen from March 2003 to June 2008 were waste burning, fuel mishaps, and unintentional ordinance detonations. Overall prevalence of noncombat burns was 19.5 burns/100,000 person-years lived. If causes specific to military operations are removed, military prevalence was 13.0/100,000. More than one-third of noncombat burns occurred in the first year of the study; a period of stability followed. A similar US population had an accidental burn prevalence of 7.1/100,000 from 2003 to 2007. Burn size, presence of inhalation injury, and burn center mortality were not different from those in a similar civilian cohort. CONCLUSIONS: Deployed service members have a greater risk of unintentional burns than a similar civilian cohort does. This is in part because of the specific dangers of military activities. More attention to deployed military burn prevention is needed, especially early in combat support operations. (J Am Coll Surg 2009;209:453-460. (C) 2009 by the American College of Surgeons) C1 [Kauvar, David S.] USA, Inst Surg Res, Clin Div, Ft Sam Houston, TX 78234 USA. RP Kauvar, DS (reprint author), USA, Inst Surg Res, Clin Div, 3400 Rawley E Chambers Bldg 3611, Ft Sam Houston, TX 78234 USA. NR 23 TC 3 Z9 4 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD OCT PY 2009 VL 209 IS 4 BP 453 EP 460 DI 10.1016/j.jamcollsurg.2009.06.367 PG 8 WC Surgery SC Surgery GA 506CD UT WOS:000270749900005 PM 19801318 ER PT J AU Pavlov, J Braida, W Ogundipe, A O'Connor, G Attygalle, AB AF Pavlov, Julius Braida, Washington Ogundipe, Adebayo O'Connor, Gregory Attygalle, Athula B. TI Generation and Detection of Gaseous W12O41-center dot and Other Tungstate Anions by Laser Desorption Ionization Mass Spectrometry SO JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY LA English DT Article ID POLYANION EQUILIBRIA; AQUEOUS SOLUTION; TUNGSTEN(VI) AB The presence of a peak centered near m/z 2862, observed for the first time for the caged dodecatungstate radical-anion, [W12O41](-center dot) enables distinguishing WO2 from WO3 by Laser Desorption Ionization mass spectrometry (LDI-MS). In addition to WO2, laser irradiation of dry deposits made from aqueous ammonium paratungstate, and calcium and lead orthotungstate also produce the [W12O41](-center dot) In contrast, spectra recorded from deposits made from aqueous Na2WO4, sodium metatungstate, and WO3, or non-aqueous calcium and lead orthotungstate, and ammonium paratungstate, failed to show the m/z 2862 peak cluster. These observations support the hypothesis that polycondensation reactions to form [W12O41](-center dot) occur solely in the presence of water. Although dry spots are irradiated for ionization, the solvent used for sample preparation plays an important role on the chemical composition endowed to ions detected. For example, the m/z 2862 peak seen from deposits made from aqueous ammonium paratungstate, and calcium and lead orthotungstate, is absent in the spectra recorded either from pristine deposits or those derived from solutions made with organic solvents such as acetonitrile or ethanol. U Am Soc Mass Spectrom 2009, 20,1782-1789) (C) 2009 Published by Elsevier Inc. on behalf of American Society for Mass Spectrometry C1 [Attygalle, Athula B.] Stevens Inst Technol, Ctr Mass Spectrometry, Dept Chem Chem Biol & Biomed Engn, Hoboken, NJ 07030 USA. [O'Connor, Gregory] USA, Demilitarizat & Environm Technol Div, Picatinny Arsenal, NJ USA. [Pavlov, Julius; Braida, Washington; Ogundipe, Adebayo] Stevens Inst Technol, Ctr Environm Syst, Dept Civil Environm & Ocean Engn, Hoboken, NJ 07030 USA. RP Attygalle, AB (reprint author), Stevens Inst Technol, Ctr Mass Spectrometry, Dept Chem Chem Biol & Biomed Engn, Hoboken, NJ 07030 USA. EM athula.attygalle@stevens.edu NR 19 TC 3 Z9 3 U1 1 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1044-0305 J9 J AM SOC MASS SPECTR JI J. Am. Soc. Mass Spectrom. PD OCT PY 2009 VL 20 IS 10 BP 1782 EP 1789 DI 10.1016/j.jasms.2009.05.015 PG 8 WC Biochemical Research Methods; Chemistry, Analytical; Chemistry, Physical; Spectroscopy SC Biochemistry & Molecular Biology; Chemistry; Spectroscopy GA 509RY UT WOS:000271037300002 PM 19631558 ER PT J AU Cuff, P Russo, M Stetz, M Stetz, T AF Cuff, P. Russo, M. Stetz, M. Stetz, T. TI The prevalence of sleep/wake disturbances in mild traumatic brain injury patients SO JOURNAL OF THE NEUROLOGICAL SCIENCES LA English DT Meeting Abstract CT 19th World Congress of Neurology CY OCT 24-30, 2009 CL Bangkok, THAILAND C1 [Cuff, P.; Russo, M.; Stetz, M.; Stetz, T.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RI Sanguansri, Luz/B-6630-2011 OI Sanguansri, Luz/0000-0003-1908-7604 NR 0 TC 1 Z9 1 U1 1 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-510X J9 J NEUROL SCI JI J. Neurol. Sci. PD OCT PY 2009 VL 285 SU 1 BP S272 EP S272 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 529ML UT WOS:000272521300967 ER PT J AU Hawksworth, JS Elster, EA Fryer, D Sheppard, F Morthole, V Krishnamurthy, G Tomori, T Brown, TS Tadaki, DK AF Hawksworth, J. S. Elster, E. A. Fryer, D. Sheppard, F. Morthole, V. Krishnamurthy, G. Tomori, T. Brown, T. S. Tadaki, D. K. TI Off-label use of recombinant factor VIIa for treatment of haemorrhage: results from randomized clinical trials SO JOURNAL OF THROMBOSIS AND HAEMOSTASIS LA English DT Article DE hemostatic agent; liver injury; lyophilization; platelets; swine; uncontrolled hemorrhage ID VON-WILLEBRAND-FACTOR; REHYDRATED LYOPHILIZED PLATELETS; LR MODULATES HYPERCOAGULABILITY; INCREASED BLOOD-LOSS; SHOCK SWINE MODEL; VONWILLEBRAND-FACTOR; TRAUMA DEATHS; RESUSCITATION; PRESERVATION; XENOTRANSPLANTATION AB Introduction: Human lyophilized platelets hold promise as a novel hemostatic infusion agent for the control of traumatic hemorrhage. Rehydrated, lyophilized platelets (Stasix) were investigated as an infusible hemostatic agent in experimental non-compressible hemorrhage, using a porcine liver injury model. Methods: Yorkshire swine underwent a grade III liver injury and uncontrolled bleeding. After 15 min, animals were infused with Stasix (n = 10) or normal saline vehicle (n = 10). At 2 h, the liver was repaired, and the animals were monitored for another4 h. Resuscitation, including blood transfusion, was administered during the hospital phase. Laboratory data, including arterial blood gas, complete blood count, thromboelastography (TEG), and coagulation parameters, were collected. All animals underwent necropsy with complete histopathologic examination. Results: Overall survival in the Stasix group [8/10 (80%)] was significantly higher than in the control group [2/10 (20%)] (P = 0.023). Mean total blood loss index (g kg-1) was lower in Stasix-treated animals (22.2 +/- 3.5) than in control animals (34.7 +/- 3.4) (P = 0.019). Hemodynamic parameters were improved in the Stasix group, and a trend towards higher hemoglobin and lower lactate was observed. Coagulation and TEG parameters were not different between the groups. One surviving animal in the Stasix group had evidence of thrombi on necropsy. Conclusions: This is the first reported study to evaluate rehydrated, lyophilized platelets as an infusible hemostatic agent for non-compressible hemorrhage. Stasix improved survival and reduced blood loss in a liver injury porcine model. However, evidence of thrombotic complications warrants further investigation prior to human use in the setting of traumatic hemorrhage. C1 [Hawksworth, J. S.; Elster, E. A.; Fryer, D.; Tomori, T.; Brown, T. S.; Tadaki, D. K.] USN, Regenerat Med Dept, Med Res Ctr, Silver Spring, MD 20910 USA. [Hawksworth, J. S.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Elster, E. A.; Sheppard, F.] Natl Naval Med Ctr, Dept Surg, Bethesda, MD USA. [Elster, E. A.; Sheppard, F.; Krishnamurthy, G.; Tadaki, D. K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Morthole, V.] Walter Reed Army Inst Res, Dept Comparat Pathol, Silver Spring, MD USA. [Tomori, T.] Tokyo Med & Dent Univ, Dept Neurosurg, Tokyo, Japan. RP Tadaki, DK (reprint author), USN, Regenerat Med Dept, Med Res Ctr, Silver Spring, MD 20910 USA. EM doug.tadaki@med.navy.mil FU BUMED FX We gratefully acknowledge C. Morrisette for his statistical advice and expertise. We also thank T. Bristol and M. G. Delima for their skillful technical assistance with the animal experiments. This research was funded by the BUMED Advanced Medical Technology Development Program. NR 44 TC 20 Z9 21 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1538-7933 J9 J THROMB HAEMOST JI J. Thromb. Haemost. PD OCT PY 2009 VL 7 IS 10 BP 1663 EP 1671 DI 10.1111/j.1538-7836.2009.03562.x PG 9 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA 498HV UT WOS:000270129200009 PM 19656278 ER PT J AU Mody, RM Zapor, M Hartzell, JD Robben, PM Waterman, P Wood-Morris, R Trotta, R Andersen, RC Wortmann, G AF Mody, Rupal M. Zapor, Michael Hartzell, Joshua D. Robben, Paul M. Waterman, Paige Wood-Morris, Robert Trotta, Richard Andersen, Romney C. Wortmann, Glenn TI Infectious Complications of Damage Control Orthopedics in War Trauma SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy/46th Annual Meeting of the Infectious-Diseases-Society-of-America CY OCT 25, 2008 CL Washington, DC SP Infect Dis Soc Amer DE Damage Control Orthopedics (DCO); Intramedullary (IM) nail infection; War trauma ID EXTERNAL FIXATION; OPEN FRACTURES; MULTIPLE INJURIES; FEMUR FRACTURES; SHAFT; AFGHANISTAN; CASUALTIES; BRIDGE; IRAQ AB Background: War-trauma, especially due to blast injury, can be associated with long bone fracture. Immediate external fixation of fractures, followed by internal fixation when the patient is medically stabilized (damage control orthopedics [DCO]), is the U.S. Army policy for war-related fractures. Data on infectious outcomes when DCO is used for war-trauma fractures are scant. Methods: A retrospective review of U.S, war-trauma patients from 2003 to 2007 with femoral or tibial fractures treated by DCO was conducted. Fisher's Exact and Mann-Whitney tests were used for comparisons. Results: Fifty-eight soldiers were identified. Fifty-five were males with a median age of 26 years (19-54 years) and a median time to internal fixation by intramedually nailing of 9 days (4-414 days). Eighty-eight percent of fractures were open, and 57% were femoral fractures. The median duration of follow-up was 447 days (20-1,340 days). Fracture site infection occurred in 40% (23 of 58), with suspected osteomyelitis in 17% (10 of 58). Of infected nails, fracture union occurred in 70% and nail retention in 57%. Median time to infection after nail placement was 15 days (0-717 days) with 75% of infections occurring by day 113. Multiple bacterial pathogens including Acinetobacter baumannii and Staphylococcus spp. were causative organisms. Blast injuries occurred in 91% of infected versus 47% of uninfected (p = 0.005). There was no difference between infections occurring in femoral (61%) versus tibial (39%) (p = 0.620) location. Conclusions: Infection was associated with 40% of DCO-associated intramedullary nails. Blast injury was a predictor of infection. Despite infection, fracture union and nail retention rates were high, suggesting a good outcome. C1 [Mody, Rupal M.; Zapor, Michael; Hartzell, Joshua D.; Robben, Paul M.; Waterman, Paige; Wood-Morris, Robert; Trotta, Richard; Wortmann, Glenn] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. [Mody, Rupal M.; Zapor, Michael; Hartzell, Joshua D.; Waterman, Paige; Wood-Morris, Robert; Trotta, Richard; Andersen, Romney C.; Wortmann, Glenn] Uniformed Serv Univ Hlth Sci, Uniformed Serv, Bethesda, MD 20814 USA. [Andersen, Romney C.] Walter Reed Army Med Ctr, Integrated Orthoped Surg Serv, Washington, DC 20307 USA. [Andersen, Romney C.] Natl Naval Med Ctr, Bethesda, MD USA. RP Wortmann, G (reprint author), Walter Reed Army Med Ctr, Infect Dis Serv, 6900 Georgia Ave,NW,Bldg 2,Ward 63, Washington, DC 20307 USA. EM glenn.wortmann@us.army.mil NR 16 TC 49 Z9 56 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 EI 1529-8809 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD OCT PY 2009 VL 67 IS 4 BP 758 EP 761 DI 10.1097/TA.0b013e3181af6aa6 PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 506BE UT WOS:000270747000014 PM 19820582 ER PT J AU Creamer, KM Edwards, MJ Shields, CH Thompson, MW Yu, CE Adelman, W AF Creamer, Kevin M. Edwards, Mary J. Shields, Cynthia H. Thompson, Mark W. Yu, Clifton E. Adelman, William TI Pediatric Wartime Admissions to US Military Combat Support Hospitals in Afghanistan and Iraq: Learning from the First 2,000 Admissions SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Pediatric Wartime trauma; Combat support hospitals; Head injury; Mortality; Military ID CHILDREN; TRAUMA; INJURY; WAR; EPIDEMIOLOGY; MORTALITY; SURVIVAL; CARE AB Background: Humanitarian and civilian emergency care accounts for up to one-third of US military combat support hospital (CSH) admissions. Almost half of these admissions are children. The purpose of this study is to describe the features of pediatric wartime admissions to deployed CSHs in Iraq and Afghanistan. Methods: A retrospective database review was conducted using the Patient Administration Systems and Biostatistics Activity. Details of 2,060 pediatric admissions to deployed CSHs were analyzed. Results: Nontraumatic diagnoses were responsible for 25% of all pediatric admissions. Penetrating injuries (76.3%) dominate the trauma admissions. The primary mechanisms of injury were gunshot wound (39%) followed by explosive injuries (32%). Categorizing the injuries by location revealed 38.3% extremity wounds, 23.6% torso injuries, 23.5% head, face, and neck injuries, and 13.3% burns. More than half of the children required two or more invasive or surgical procedures, 19.8% needed a transfusion, and 5.6% required mechanical ventilation. The mortality rate was 6.9%. The primary cause of death involved head trauma (29.5%) and burns (27.3%), followed by infectious diagnoses (7.2%). The case fatality rate for head injury and burn patients was 20.1% and 15.9%, respectively, in contrast to the fatality rate for all other diagnoses at 3.8% (p < 0.01). Excluding emergency department deaths, mortality rates for Afghanistan (6.2%) and Iraq (3.9%) significantly differ (p < 0.02). Conclusion: Pediatric patients account for similar to 10% of all CSH admissions in Afghanistan and Iraq. Burns and penetrating head injury account for the majority of pediatric mortality at the CSH. C1 [Creamer, Kevin M.; Yu, Clifton E.; Adelman, William] Walter Reed Army Med Ctr, Dept Pediat, Silver Spring, MD 20902 USA. [Creamer, Kevin M.; Thompson, Mark W.; Yu, Clifton E.; Adelman, William] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. [Edwards, Mary J.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. [Shields, Cynthia H.] Uniformed Serv Univ Hlth Sci, Dept Anesthesiol, Bethesda, MD 20814 USA. [Edwards, Mary J.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. [Thompson, Mark W.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. RP Creamer, KM (reprint author), Walter Reed Army Med Ctr, Dept Pediat, 3816 Woodridge Ave, Silver Spring, MD 20902 USA. EM kevin.creamer@amedd.army.mil NR 22 TC 36 Z9 36 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD OCT PY 2009 VL 67 IS 4 BP 762 EP 768 DI 10.1097/TA.0b013e3181b1e15 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 506BE UT WOS:000270747000015 PM 19820583 ER PT J AU Alam, HB Bice, LM Butt, MU Cho, SD Dubick, MA Duggan, M Englehart, MS Holcomb, JB Morris, MS Prince, MD Schreiber, MA Shults, C Sondeen, JL Tabbara, M Tieu, BH Underwood, SA AF Alam, Hasan B. Bice, Leticia M. Butt, Muhammad U. Cho, S. David Dubick, Michael A. Duggan, Michael Englehart, Michael S. Holcomb, John B. Morris, Melanie S. Prince, M. Dale Schreiber, Martin A. Shults, Christian Sondeen, Jill L. Tabbara, Malek Tieu, Brandon H. Underwood, Samantha A. CA Hemostatic Resuscitation Res Grp TI Testing of Blood Products in a Polytrauma Model: Results of a Multi-Institutional Randomized Preclinical Trial SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 67th Annual Meeting of the American-Association-for-the-Surgery-of-Trauma CY SEP 24-27, 2008 CL Maui, HI SP Amer Assoc Surg Trauma DE Plasma; Hemorrhage; Shock; Coagulopathy; Liver injury; Polytrauma; Acidosis; Hypothermia ID FRESH-FROZEN PLASMA; ACUTE TRAUMATIC COAGULOPATHY; WHOLE-BLOOD; CELL TRANSFUSIONS; CUMULATIVE RISKS; RESUSCITATION; TEMPERATURE; MORTALITY; MILITARY; HYPOPERFUSION AB Introduction: Trauma-induced coagulopathy, acidosis, and hypothermia form a "lethal triad" that is difficult to treat and is associated with extremely high mortality. This study was performed at three academic centers to evaluate whether resuscitation with blood components could reverse the coagulopathy in a complex polytrauma model. Methods: Yorkshire swine (40 5 kg) were subjected to a three-phase protocol: (a) "Prehospital" phase femur fracture, hemorrhage (60% blood volume), and 30 minutes shock + infusion of saline (3 x shed blood) + induction of hypother-mia (33 degrees C); (b) "Early hospital" phase = grade V liver injury; and (c) "Operative" phase = liver packing. After liver packing, the animals (n = 60) were randomized to the following groups: (1) Sham-instrumentation and anesthesia without hemorrhage/injuries, (2) fresh whole blood (FWB), (3) 6% hetastarch (Hextend), (4) fresh frozen plasma/packed RBCs in 1:1 ratio (1:1 FFP/PRBC), and (5) FFP alone. Treatment volumes were equal to the volume of shed blood. Hemodynamic and physiologic parameters and coagulation profile (thrombelastography, prothrombin time, activated partial thromboplastin time, international normalized ratio, and platelets) were monitored during the experiment and for 4 hours posttreatment. Results: At the end of prehospital phase, animals had developed significant acidosis (lactate >5 mmol/L and base deficit >9 mmol/L) and coagulopathy. Posttreatment mortality rates were 85% and 0% for the Hextend and blood component treated groups, respectively (p < 0.05). Hemodynamic parameters and survival rates were similar in groups that were treated with blood products (FWB, FFP, and FFP:PRBC). Animals treated with FFP and Hextend had significant anemia compared with the groups that received red blood cells (FWB and FFP:PRBC). Treatment with FFP and FFP:PRBC corrected the coagulopathy as effectively as FWB, whereas Hextend treatment worsened coagulopathy. Conclusions: In this reproducible model, we have shown that trauma-associated coagulopathy is made worse by hetastarch, but it can be rapidly reversed with the administration of blood components. Impressively, infusion of FFP, even without any red blood cells, can correct the coagulopathy and result in excellent early survival. C1 [Alam, Hasan B.; Butt, Muhammad U.; Duggan, Michael; Shults, Christian; Tabbara, Malek] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Trauma, Boston, MA USA. [Bice, Leticia M.; Dubick, Michael A.; Holcomb, John B.; Prince, M. Dale; Sondeen, Jill L.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Cho, S. David; Englehart, Michael S.; Morris, Melanie S.; Schreiber, Martin A.; Tieu, Brandon H.; Underwood, Samantha A.] Oregon Hlth & Sci Univ, Dept Surg, Portland, OR 97201 USA. RP Alam, HB (reprint author), Massachusetts Gen Hosp, Div Trauma Emergency Surg & Surg Crit Care, 165 Cambridge St,Suite 810, Boston, MA 02114 USA. EM hbalam@partners.org OI Tabbara, Malek/0000-0003-1046-7803 NR 38 TC 39 Z9 41 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD OCT PY 2009 VL 67 IS 4 BP 856 EP 864 DI 10.1097/TA.0b013e3181b5ae75 PG 9 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 506BE UT WOS:000270747000029 PM 19820596 ER PT J AU Miller, MA Coon, TP AF Miller, Michael A. Coon, Troy P. TI Emergency Department Diagnosis of ACL Tears: A Response to Guillodo et al. SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Letter C1 [Miller, Michael A.; Coon, Troy P.] Tripler Army Med Ctr, Dept Emergency Med, Honolulu, HI 96859 USA. RP Miller, MA (reprint author), Tripler Army Med Ctr, Dept Emergency Med, Honolulu, HI 96859 USA. NR 1 TC 1 Z9 1 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD OCT PY 2009 VL 67 IS 4 BP 893 EP 893 PG 1 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 506BE UT WOS:000270747000037 PM 19820606 ER PT J AU Baerlocher, MO Munk, PL Radvany, MG Murphy, TP Murphy, KJ AF Baerlocher, Mark Otto Munk, Peter L. Radvany, Martin G. Murphy, Timothy P. Murphy, Kieran J. TI Vertebroplasty, Research Design, and Critical Analysis SO JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY LA English DT Article ID MEDICAL LITERATURE; USERS GUIDES; RANDOMIZED-TRIAL; PREVENTION; FRACTURES; THERAPY; ARTICLE C1 [Baerlocher, Mark Otto; Murphy, Kieran J.] Univ Toronto, Dept Med Imaging, Toronto, ON M5S 3E2, Canada. [Munk, Peter L.] Univ British Columbia, Vancouver Gen Hosp, Dept Radiol, Vancouver, BC V5Z 1M9, Canada. [Radvany, Martin G.] Brooke Army Med Ctr, Dept Radiol, Ft Sam Houston, TX 78234 USA. [Murphy, Timothy P.] Brown Univ, Rhode Isl Hosp, Dept Diagnost Imaging, Div Vasc & Intervent Radiol, Providence, RI 02903 USA. RP Murphy, KJ (reprint author), Univ Toronto, Dept Med Imaging, Fitzgerald Bldg,150 Coll St,Room 112, Toronto, ON M5S 3E2, Canada. EM kieran.murphy@uhn.on.ca NR 9 TC 9 Z9 9 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1051-0443 EI 1535-7732 J9 J VASC INTERV RADIOL JI J. Vasc. Interv. Radiol. PD OCT PY 2009 VL 20 IS 10 BP 1277 EP 1278 DI 10.1016/j.jvir.2009.08.017 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging; Peripheral Vascular Disease SC Radiology, Nuclear Medicine & Medical Imaging; Cardiovascular System & Cardiology GA 504EQ UT WOS:000270598700003 PM 19800539 ER PT J AU Flournoy, WS Mani, S AF Flournoy, W. S. Mani, S. TI Percutaneous external jugular vein catheterization in piglets using a triangulation technique SO LABORATORY ANIMALS LA English DT Article DE Piglet; percutaneous; external jugular vein; catheterization ID CENTRAL VENOUS CATHETERIZATION; PIGS; CANNULATION; INFANTS; PLACEMENT; LANDMARK; STRESS; ACCESS AB Chronic jugular vein or central venous cannulation is routinely performed in human and animal patients for access to blood circulation. In mature swine, chronic catheter placement techniques have typically involved venous isolation via extensive cutdown, blunt dissection and manipulation of ventral neck tissues prior to catheter placement. More recently, guide-wire-assisted percutaneous techniques have become standard practice in human and veterinary medicine due to the minimization of soft tissue and vessel damages. Laboratory animal piglets are becoming more popular research models because of their immature immunological system, ease of handling and costs. However, external jugular veins are very difficult to catheterize in paediatric animals including freshly weaned piglets. The objective of this study was to develop a simple, safe and efficient method for external jugular vein cannulation in young piglets. In total, 20 piglets were anaesthetized and percutaneously catheterized with a guide-wire technique using palpable anatomical landmarks and triangulation. With this minimally invasive catheterization, it has allowed our veterinarians and veterinary technicians to quickly and easily obtain central venous access in piglets undergoing operative procedures. C1 [Flournoy, W. S.] Walter Reed Army Inst Res, Div Vet Med, Dept Vet Surg, Silver Spring, MD 20910 USA. [Mani, S.] Walter Reed Army Inst Res, Div Mol Pathol, Dept Pathol, Silver Spring, MD 20910 USA. RP Flournoy, WS (reprint author), Bldg 435,Pierce Rd, Ft Shafter, HI 96858 USA. EM william.s.flournoy@us.army.mil FU USARMC; ILIR FX We would like to express our sincere thanks to Dr Marti Jett, Chief of Division of Molecular Pathology, for her constant support in this project. We also thank the veterinary technicians of the Department of Veterinary Surgery for helping us complete this project. This research was supported by grants (USARMC) and seed funding (ILIR). NR 45 TC 3 Z9 3 U1 0 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0023-6772 EI 1758-1117 J9 LAB ANIM-UK JI Lab. Anim. PD OCT PY 2009 VL 43 IS 4 BP 344 EP 349 DI 10.1258/la.2009.0080092 PG 6 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 515VD UT WOS:000271500100005 PM 19535391 ER PT J AU Landgren, O Weiss, BM AF Landgren, O. Weiss, B. M. TI Patterns of monoclonal gammopathy of undetermined significance and multiple myeloma in various ethnic/racial groups: support for genetic factors in pathogenesis SO LEUKEMIA LA English DT Review DE MGUS; susceptibility; racial disparity; genetic; African American; immune related ID UNITED-STATES; AFRICAN-AMERICAN; FAMILIAL MYELOMA; INTERGROUPE FRANCOPHONE; SIGNIFICANCE MGUS; ADULT-POPULATION; PREVALENCE; CANCER; RISK; HISTORY AB Monoclonal gammopathy of undetermined significance (MGUS) is one of the most common premalignant disorders in Western countries. Recent studies show that almost every multiple myeloma (MM) case is preceded by an MGUS stage. Interestingly, prevalence and incidence patterns for MGUS and MM show striking disparity patterns across ethnic/racial groups, most notably the two-to threefold increase in both these disorders in African Americans compared with Caucasians. In contrast, studies on Asian patients show lower prevalence/incidence for MGUS/MM compared with Caucasians. Familial aggregation for both MGUS and MM has been observed; the risk for MGUS or MM in family members with these disorders is increased about two-to three fold compared with the general population. Although underlying mechanisms remain unclear, there is evidence of heterogeneity among MGUS patients from different ethnic/racial groups. For example, compared with Caucasians, African- American and African MGUS patients have reportedly lower rates of immunoglobulin M (IgM) MGUS (versus IgG/IgA MGUS) and higher rates of unquantifiable immunoglobulins (Igs). This review focuses on racial disparity and familial aggregation patterns for MGUS and MM and discusses how these observations provide novel clues with regard to pathogenesis. Leukemia (2009) 23, 1691-1697; doi: 10.1038/leu. 2009.134; published online 9 July 2009 C1 [Landgren, O.] NCI, Med Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. [Weiss, B. M.] Walter Reed Army Med Ctr, Dept Med, Hematol Oncol Serv, Washington, DC 20307 USA. RP Landgren, O (reprint author), NCI, Med Oncol Branch, Ctr Canc Res, NIH, 9000 Rockville Pike,Bldg 10,Room 13N240, Bethesda, MD 20892 USA. EM landgreo@mail.nih.gov FU National Cancer Institute (NCI); National Institutes of Health (NIH), Bethesda, Maryland FX This research was supported by the Intramural Research Program of the National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland. The study sponsors did not have any role in the design of the study, interpretation of the data, the writing of the paper or the decision to submit the paper for publication. We thank Dr William F Anderson, NCI/NIH for help in creating Figure 1. NR 61 TC 79 Z9 79 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0887-6924 J9 LEUKEMIA JI Leukemia PD OCT PY 2009 VL 23 IS 10 BP 1691 EP 1697 DI 10.1038/leu.2009.134 PG 7 WC Oncology; Hematology SC Oncology; Hematology GA 506YX UT WOS:000270816300002 PM 19587704 ER PT J AU Grujicic, M Bell, WC Arakere, G He, T Cheeseman, BA AF Grujicic, M. Bell, W. C. Arakere, G. He, T. Cheeseman, B. A. TI A meso-scale unit-cell based material model for the single-ply flexible-fabric armor SO MATERIALS & DESIGN LA English DT Article DE Flexible armor; Meso-scale unit-cell material model; High-performance fibers; Ballistic performance ID FINITE-DEFORMATION THEORY; PLAIN-WEAVE FABRICS; BALLISTIC IMPACT; WOVEN FABRICS; FRICTION; SIMULATION; BEHAVIOR AB A meso-scale unit-cell based material model for a prototypical plain-woven single-ply flexible armor is developed and implemented in a material user subroutine for use in commercial explicit finite element programs. The main intent of the model is to attain computational efficiency when calculating the mechanical response of the multi-ply fabric-based flexible armor material during its impact with various projectiles without significantly sacrificing the key physical aspects of the fabric microstructure, architecture and behavior. To validate the new model, a comparative finite element method (FEM) analysis is carried out in which: (a) the plain-woven single-ply fabric is modeled using conventional shell elements and weaving is done in an explicit manner by snaking the yarns through the fabric and (b) the fabric is treated as a planar continuum surface composed of conventional shell elements to which the new meso-scale unit-cell based material model is assigned. The results obtained show that the material model provides a reasonably good description for the fabric deformation and fracture behavior under different combinations of fixed and free boundary conditions. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Grujicic, M.; Bell, W. C.; Arakere, G.; He, T.] Clemson Univ, Dept Mech Engn, Int Ctr Automot Res CU ICAR, Clemson, SC 29634 USA. [Cheeseman, B. A.] USA, Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, Int Ctr Automot Res CU ICAR, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM mica.grujicic@ces.clemson.edu FU US Army/Clemson University Cooperative Agreements [W911NF-04-2-0024, W911NF-06-2-0042] FX The material presented in this paper is based on work supported by the US Army/Clemson University Cooperative Agreements W911NF-04-2-0024 and W911NF-06-2-0042. The authors are indebted to Dr. Fred Stanton for the support and a continuing interest in the present work. NR 25 TC 15 Z9 15 U1 0 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0261-3069 J9 MATER DESIGN JI Mater. Des. PD OCT PY 2009 VL 30 IS 9 BP 3690 EP 3704 DI 10.1016/j.matdes.2009.02.008 PG 15 WC Materials Science, Multidisciplinary SC Materials Science GA 469JA UT WOS:000267892200046 ER PT J AU Fuselier, EJ Narcowich, FJ Ward, JD Wright, GB AF Fuselier, Edward J. Narcowich, Francis J. Ward, Joseph D. Wright, Grady B. TI ERROR AND STABILITY ESTIMATES FOR SURFACE-DIVERGENCE FREE RBF INTERPOLANTS ON THE SPHERE SO MATHEMATICS OF COMPUTATION LA English DT Article DE Sphere; vector fields; incompressible fluids; radial basis functions; numerical modeling; stream function ID SCATTERED-DATA INTERPOLATION; RADIAL BASIS FUNCTIONS; SHAPE-PARAMETERS; APPROXIMATION; BOUNDS; EQUATIONS; KERNELS AB Recently, a new class of surface-divergence free radial basis function interpolants has been developed for surfaces in R(3). In this paper, several approximation results for this class of interpolants will be derived in the case of the sphere, S(2). In particular, Sobolev-type error estimates are obtained, as well as optimal stability estimates for the associated interpolation matrices. In addition, a Bernstein estimate and an inverse theorem are also derived. Numerical validation of the theoretical results is also given. C1 [Fuselier, Edward J.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Narcowich, Francis J.; Ward, Joseph D.] Texas A&M Univ, Dept Math, College Stn, TX 77843 USA. [Wright, Grady B.] Boise State Univ, Dept Math, Boise, ID 83725 USA. RP Fuselier, EJ (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM edward.fuselier@usma.edu; fnarc@math.tamu.edu; jward@math.tamu.edu; wright@diamond.boisestate.edu FU National Science Foundation [DMS-0504353, ATM-0801309] FX The fourth author's research was supported by grant ATM-0801309 from the National Science Foundation. NR 45 TC 6 Z9 7 U1 0 U2 1 PU AMER MATHEMATICAL SOC PI PROVIDENCE PA 201 CHARLES ST, PROVIDENCE, RI 02940-2213 USA SN 0025-5718 J9 MATH COMPUT JI Math. Comput. PD OCT PY 2009 VL 78 IS 268 BP 2157 EP 2186 PG 30 WC Mathematics, Applied SC Mathematics GA 506HQ UT WOS:000270766200014 ER PT J AU Anderson-Barnes, VC McAuliffe, C Swanberg, KM Tsao, JW AF Anderson-Barnes, Victoria C. McAuliffe, Caitlin Swanberg, Kelley M. Tsao, Jack W. TI Phantom limb pain - A phenomenon of proprioceptive memory? SO MEDICAL HYPOTHESES LA English DT Article ID STUMP PAIN; AMPUTEES; PERCEPTION; AMPUTATION; MOVEMENTS; MECHANISMS AB Despite the amount of research that has been conducted on phantom limb pain (PLP), the etiology of the condition remains unknown, and treatment options are limited. After an individual loses a limb, the brain continues to detect the presence of the missing limb even though it is no longer attached to the body, likely through proprioceptive signals. The majority of patients with amputations either report the feeling of volitional control over their phantom or a phantom limb that is frozen in a specific position. Many patients also experience PLP. Here we propose a new theory, termed "proprioceptive memory," which may explain some of the unique experiences amputees encounter. We also suggest that memories of the limb's position prior to amputation remain embedded within an individual's subconscious, and pain memories that may be associated with each limb position contribute not only to PLP, but to the experience of a fixed or frozen limb. We suspect that there are memory networks for pain - and other sensations, either positive or negative - that are associated with each limb position, and propose that these memories evolved to protect our bodies from repeated injury. A discussion of mirror therapy as a treatment option for PLP is also provided, as well as an explanation for the efficacy of mirror therapy. The paper offers a unique insight into how and why amputees experience these unusual phenomena. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Anderson-Barnes, Victoria C.; McAuliffe, Caitlin; Swanberg, Kelley M.] Walter Reed Army Med Ctr, Dept Orthoped & Rehabil, Washington, DC 20307 USA. [Tsao, Jack W.] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. RP Anderson-Barnes, VC (reprint author), Walter Reed Army Med Ctr, Dept Orthoped & Rehabil, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM victoria.anderson-barnes@amedd.army.mil NR 28 TC 12 Z9 13 U1 2 U2 13 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 0306-9877 EI 1532-2777 J9 MED HYPOTHESES JI Med. Hypotheses PD OCT PY 2009 VL 73 IS 4 BP 555 EP 558 DI 10.1016/j.mehy.2009.05.038 PG 4 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 501IH UT WOS:000270374400027 PM 19556069 ER PT J AU Urso, ML AF Urso, Maria L. TI Regulation of Muscle Atrophy: Wasting Away from the Outside In: An Introduction SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Editorial Material DE DISUSE; DETRAINING; AGING; MUSCLE FUNCTION; APOPTOSIS; COUNTERMEASURES ID SKELETAL-MUSCLE; UBIQUITIN LIGASES; GENE-EXPRESSION; DISUSE ATROPHY; MESSENGER-RNA; PROTEIN; IMMOBILIZATION; PATHWAY; HUMANS; FIBERS AB URSO, M. L. Regulation of Muscle Atrophy: Wasting Away from the Outside In: An Introduction. Med. Sci. Sports Exerc., Vol. 41, No. 10. pp. 1856-1859, 2009. whereas it is clear that periods of detraining, disuse, injury and aging are marked by losses in skeletal muscle Mass and function, the emerging literature suggests that there are unique molecular signaling alterations depending oil the perturbation. Understanding the phenotypical adaptations in skeletal muscle and factors that are thought to promote or inhibit genes elucidate how tire muscular system responds to decreases in activity. Recent advances in the involved in the atrophy program will discipline have identified specific and innovative methods to promote skeletal muscle hypertrophy including gene therapy, pharmacological, and nutritional interventions. The same success has not been met concerning, attenuating skeletal muscle atrophy. If novel approaches are to be implemented in humans to mitigate disuse- and age-related skeletal muscle loss. it is imperative that we evaluate critical regulators of skeletal muscle atrophy front a system to the cellular level. The symposium "Regulation of Muscle Atrophy: Wasting Away from the Outside In" was presented at the ACSM Annual Meeting in Indianapolis on May 29, 2008, to provide an overview of the skeletal muscle atrophy literature and our current understanding of the atrophy program from the whole system to the molecular level. In addition, this symposium addressed the feasibility of intervening with specific countermeasures to attenuate atrophy. This introduction identifies the scope of the symposium, which evaluates our Current understanding of the atrophy program and how this information can facilitate tire development of effective countermeasures. C1 USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. RP Urso, ML (reprint author), USA, Environm Med Res Inst, Mil Performance Div, Bldg 42,Kansas St, Natick, MA 01760 USA. EM maria.urso@us.army.mil OI Urso, Maria/0000-0001-8906-4673 NR 30 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD OCT PY 2009 VL 41 IS 10 BP 1856 EP 1859 DI 10.1249/MSS.0b013e3181a643b2 PG 4 WC Sport Sciences SC Sport Sciences GA 499FI UT WOS:000270202700004 PM 19727029 ER PT J AU Urso, ML AF Urso, Maria L. TI Disuse Atrophy of Human Skeletal Muscle: Cell Signaling and Potential Interventions SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article; Proceedings Paper CT 55th Annual Meeting of the American-College-of-Sports-Medicine CY MAY 28-31, 2008 CL Indianapolis, IN SP Amer Coll Sports Med DE AKT; MTOR; UBIQUITIN; IMMOBILIZATION; UNLOADING; DETRAINING; SPINAL CORD INJURY; COUNTERMEASURE; GENE EXPRESSION ID SPINAL-CORD-INJURY; UBIQUITIN-PROTEASOME PATHWAY; FOXO TRANSCRIPTION FACTORS; GENE-EXPRESSION; PROTEIN-SYNTHESIS; RESISTANCE EXERCISE; MESSENGER-RNA; CONTRACTILE ACTIVITY; WEIGHT-BEARING; OLDER-ADULTS AB URSO, M. L. Disuse Atrophy of Human Skeletal Muscle: Cell Signaling and Potential Interventions. Med. Sci. Sports Exerc., Vol. 41, No. 10, pp. 1860-1868, 2009. In response to atrophic stimuli, physical alterations include decreases in fiber diameter and contractile protein content, Despite he fact dun these phenotypical alterations have been well characterized, the signaling pathways that mediate these adaptations are Still under investigation. There have been significant advances in the past few years delineating signal transduction pathways that regulate protein turnover. In the process of evaluating the effect of various atrophy-inducing stimuli on signal transduction pathways in skeletal muscle, it is apparent that differences do exist concerning both transcriptional and translational adaptations. To this end, it is hypothesized that the processes responsible for invoking skeletal muscle atrophy are unique, despite similar upstream signals and downstream phenotypical adaptations. If this is the case, countermeasures to attenuate atrophy may be more effective if they are designed to accommodate molecular alterations specific to the atrophic stimulus. The ann of this review was to characterize the recent work in humans elucidating the molecular basis of skeletal muscle atrophy in response to immobilization, unloading. spinal cord injury, and detraining to highlight the possibility that all skeletal muscle atrophy is not the same. With ail increased understanding of the unique signaling pathways that regulate skeletal muscle protein turnover in the face of various atrophy models, it is possible to exploit these pathways to develop countermeasures to prevent or attenuate atrophy. Eugenics, gene therapy, pharmacology, nutritional, and physical countermeasures are discussed concerning their potential to treat or mitigate atrophy. C1 USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. RP Urso, ML (reprint author), USA, Environm Med Res Inst, Mil Performance Div, Bldg 42,Kansas St, Natick, MA 01760 USA. EM maria.urso@us.army.mil OI Urso, Maria/0000-0001-8906-4673 NR 79 TC 8 Z9 8 U1 2 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD OCT PY 2009 VL 41 IS 10 BP 1860 EP 1868 DI 10.1249/MSS.0b013e3181a6458a PG 9 WC Sport Sciences SC Sport Sciences GA 499FI UT WOS:000270202700005 PM 19727028 ER PT J AU Morgan, AE Lappan, CM Fraser, SL Hospenthal, DR Murray, CK AF Morgan, Ana E. Lappan, Charles M. Fraser, Susan L. Hospenthal, Duane R. Murray, Clinton K. TI Infectious Disease Teleconsultative Support of Deployed Healthcare Providers SO MILITARY MEDICINE LA English DT Article ID US ARMY TELEMEDICINE; RESEARCH-CENTER TATRC; PROGRAM AB Specialty teleconsultation is being provided to deployed healthcare providers in the current wars in Iraq and Afghanistan through the use of the Army Knowledge Online (AKO) e-mail service. We reviewed 374 teleconsults received by the infectious disease (ID) service between January 2005 and June 2008. The patients were 65% male, 12% female, 33% the gender was not stated or the consult did not involve an individual, and 41% were U.S. Army. The average response time was under 5 hours. Ninety-one percent of consults originated from the U.S. Central Command area of responsibility. Consults included questions pertaining to therapy (42%), diagnosis (21%), prevention (13%), or mixed categories (24%). Bacterial infections were the most common (32%), followed by parasitic infections (16%). Tuberculosis and methicillin-resistant Staphylococcus aureus accounted for 13% and 8% of consults, respectively. Data from this program should be useful in focusing predeployment provider training. It also provides the military ID community situational awareness of problems encountered in theater. C1 [Morgan, Ana E.; Hospenthal, Duane R.; Murray, Clinton K.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Lappan, Charles M.] Telehlth Great Plains Reg Med Command, Ft Sam Houston, TX 78234 USA. [Fraser, Susan L.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Fraser, Susan L.; Hospenthal, Duane R.; Murray, Clinton K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Morgan, AE (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 16 TC 6 Z9 6 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2009 VL 174 IS 10 BP 1055 EP 1060 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 601LI UT WOS:000278060500008 PM 19891217 ER PT J AU Payne, KS Klein, TA Otto, JL Kim, HC Chong, ST Ha, SJ Gu, SH Jeong, JH Baek, LJ Song, JW AF Payne, Kevin S. Klein, Terry A. Otto, Jean L. Kim, Heung-Chul Chong, Sung-Tae Ha, Si Jung Gu, Se Hun Jeong, Ji Hae Baek, Luck Ju Song, Jin-Won TI Seasonal and Environmental Determinants of Leptospirosis and Scrub Typhus in Small Mammals Captured at a US Military Training Site (Dagmar North), Republic of Korea, 2001-2004 SO MILITARY MEDICINE LA English DT Article ID SPOTTED-FEVER GROUP; PREVALENCE; PROVINCE AB Objective: This study sought to identify seasonal and environmental determinants of scrub typhus, murine typhus, and leptospirosis in small mammals trapped at Dagmar North training area, Gyeonggi Province, South Korea. Methods: Small mammals received titer assays to the aforementioned diseases. Logistic regression analyses were conducted to determine whether associations existed between risk of small-mammal infection and independent variables such as season of capture, habitat, small-mammal species, and sex. Results: Murine typhus was not detected among the animals assayed. Risk of scrub typhus infection was associated with season, habitat, and small-mammal species. Risk of leptospirosis infection was associated with season and habitat. Conclusions: These findings indicate determinants of infection exist for scrub typhus and leptospirosis at this training site. This information can be used for developing appropriate preventive medicine plans and coordinating troop activity during periods of reduced exposure decreasing the likelihood of disease transmission to humans. C1 [Payne, Kevin S.] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD 20910 USA. [Klein, Terry A.] USAMEDDAC Korea, Force Hlth Protect, Unit 15281, APO, AP 96205 USA. [Otto, Jean L.] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD 20910 USA. [Kim, Heung-Chul; Chong, Sung-Tae] 5th Med Detachment, 168th Multifunct Med Battal, 65th Med Brigade, Unit 15247, APO, AP 96205 USA. [Ha, Si Jung; Gu, Se Hun; Jeong, Ji Hae; Baek, Luck Ju; Song, Jin-Won] Korea Univ, Coll Med, Dept Microbiol, Seoul 136705, South Korea. RP Payne, KS (reprint author), Walter Reed Army Inst Res, Div Prevent Med, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. RI Valle, Ruben/A-7512-2013 FU Global Emerging Infections Surveillance and Response System, Silver Spring, MD; U.S. Army Center for Health Promotion and Preventive Medicine; Global Emerging Infections Surveillance and Response System; National Center for Military Intelligence, Fort Detrick, MD FX We thank the commanders and their personnel from the 5th and 38th Medical Detachments of the 168th Multifunctional Medical Battalion of the 18th Medical Command for their support in conducting rodent surveillance at Dagmar North. We acknowledge Ms. Suk-Hee Yi for maintaining the database of the rodent collections and diagnostic results. We also thank Dr. Joel Gaydos, Global Emerging Infections Surveillance and Response System, Silver Spring, MD, for his support throughout this project. Financial support funding for portions of this work was provided by the U.S. Army Center for Health Promotion and Preventive Medicine, Global Emerging Infections Surveillance and Response System, and the National Center for Military Intelligence, Fort Detrick, MD. NR 14 TC 5 Z9 5 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2009 VL 174 IS 10 BP 1061 EP 1067 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 601LI UT WOS:000278060500009 PM 19891218 ER PT J AU Margolis, LM Grediagin, A Koenig, C Sanders, LF AF Margolis, Lee M. Grediagin, Ann Koenig, Chad Sanders, LesLee F. TI Effectiveness and Acceptance of Web-Based Learning Compared to Traditional Face-to-Face Learning for Performance Nutrition Education SO MILITARY MEDICINE LA English DT Article ID WORLD-WIDE-WEB; NURSING-RESEARCH; DELIVERY AB The objective of this study was to assess the effectiveness and acceptance of Web-based (WB) versus face-to-face (FF) lecturing. There were 48 soldiers stationed at Fort Bragg, NC who completed the study, participating in either a Web-based or face-to-face lecture on nutrition for performance. The lecture was 30 minutes long. Participants completed a prequiz and survey before the lecture and a postquiz and survey at its conclusion. Results showed there was no difference in the effectiveness of the two mediums on the basis of postquiz scores (Web-based group = 75.68; face-to-face group = 73.27; p = 0.436). Change in scores from pre to post also showed no difference between the two groups (p = 0.375). Assessing the acceptance of the two teaching mediums, there was no significant difference reported, except for the instructor's ability to answer questions (p = 0.05). The conclusion of this study is that Web-based learning can be an effective and acceptable tool for registered dietitians to educate soldiers on nutrition for performance. C1 [Margolis, Lee M.; Koenig, Chad] Womack Army Med Ctr, ATTN MCXC NCD, Ft Bragg, NC 28310 USA. [Grediagin, Ann] Army Med Dept Ctr & Sch, Ft Sam Houston, TX 78234 USA. [Sanders, LesLee F.] Womack Army Med Ctr, ATTN MCXC R, Ft Bragg, NC 28310 USA. RP Margolis, LM (reprint author), Womack Army Med Ctr, ATTN MCXC NCD, Stop A,2817 Reilly Rd, Ft Bragg, NC 28310 USA. NR 21 TC 1 Z9 1 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD OCT PY 2009 VL 174 IS 10 BP 1095 EP 1099 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 601LI UT WOS:000278060500014 PM 19891223 ER PT J AU Ross, AE Taylor, KF Kirk, KL Murphy, KP AF Ross, Amy E. Taylor, Kenneth F. Kirk, Kevin L. Murphy, Kevin P. TI Functional Outcome of Multiligamentous Knee Injuries Treated Arthroscopically in Active Duty Soldiers SO MILITARY MEDICINE LA English DT Article ID LIMITATIONS; DISLOCATION; DISORDERS; FRACTURES; SPORTS; RETURN; JOINT; ARMY AB Purpose: To evaluate variables unique to our military population to determine whether we can be better predict functional outcome and return to duty of active duty military soldiers with multiligament knee disruption following arthroscopically assisted reconstruction. Materials and Methods: Twenty-four active duty Army personnel who underwent arthroscopically assisted reconstruction of multiple ligament disruption by the same surgeon were enrolled in this study. Postoperatively, a standardized knee joint questionnaire was administered and current vocational and recreational status was evaluated. Demographic data as well as military-specific factors to include rank, military occupation specialty, associated injuries, and retention on active duty were reviewed for these patients to determine their correlation with outcome. Results: Overall, 13 (54%) remained on active duty following surgical reconstruction of their knee. There was a positive correlation between military rank and return to military duty. We were unable to correlate physical job demand to postinjury duty status. The Cincinnati Knee Ligament Rating Scale indicated that most soldiers were able to perform sports at "half speed," with "some limits" in daily living function scores. Conclusion: Arthroscopically assisted multiligament knee reconstruction enabled only a slight majority of active duty soldiers to return to duty following reconstruction and rehabilitation of this devastating injury. C1 [Ross, Amy E.; Taylor, Kenneth F.; Kirk, Kevin L.; Murphy, Kevin P.] Walter Reed Army Med Ctr, Dept Orthopaed Surg & Rehabil, Washington, DC 20307 USA. RP Ross, AE (reprint author), Walter Reed Army Med Ctr, Dept Orthopaed Surg & Rehabil, 6900 Georgia Ave, Washington, DC 20307 USA. NR 12 TC 2 Z9 2 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2009 VL 174 IS 10 BP 1113 EP 1117 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 601LI UT WOS:000278060500018 PM 19891227 ER PT J AU Resio, DT Irish, J Cialone, M AF Resio, Donald T. Irish, Jennifer Cialone, Mary TI A surge response function approach to coastal hazard assessment - part 1: basic concepts SO NATURAL HAZARDS LA English DT Article DE Natural hazards; Storm surge; Hurricane ID HURRICANES; MODEL; WIND AB This paper reviews historical methods for estimating surge hazards and concludes that the class of solutions produced with Joint Probability Method (JPM) solutions provides a much more stable estimate of hazard levels than alternative methods. We proceed to describe changes in our understanding of the winds in hurricanes approaching a coast and the physics of surge generation that have required recent modifications to procedures utilized in earlier JPM studies. Of critical importance to the accuracy of hazard estimates is the ability to maintain a high level of fidelity in the numerical simulations while allowing for a sufficient number of simulations to populate the joint probability matrices for the surges. To accomplish this, it is important to maximize the information content in the sample storm set to be simulated. This paper introduces the fundamentals of a method based on the functional specification of the surge response for this purpose, along with an example of its application in the New Orleans area. A companion paper in this special issue (Irish et al. 2009) provides details of the portion of this new method related to interpolating/extrapolating along spatial dimensions. C1 [Resio, Donald T.; Cialone, Mary] ERDC CHL, Vicksburg, MS USA. [Irish, Jennifer] Texas A&M Univ, College Stn, TX USA. RP Resio, DT (reprint author), ERDC CHL, Vicksburg, MS USA. EM donald.t.resio@usace.army.mil OI Irish, Jennifer/0000-0002-2429-5953 NR 23 TC 28 Z9 30 U1 1 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0921-030X J9 NAT HAZARDS JI Nat. Hazards PD OCT PY 2009 VL 51 IS 1 BP 163 EP 182 DI 10.1007/s11069-009-9379-y PG 20 WC Geosciences, Multidisciplinary; Meteorology & Atmospheric Sciences; Water Resources SC Geology; Meteorology & Atmospheric Sciences; Water Resources GA 490VG UT WOS:000269535200011 ER PT J AU Irish, JL Resio, DT Cialone, MA AF Irish, Jennifer L. Resio, Donald T. Cialone, Mary A. TI A surge response function approach to coastal hazard assessment. Part 2: Quantification of spatial attributes of response functions SO NATURAL HAZARDS LA English DT Article DE Storm surge; Coastal flooding; Coastal hazards; Tropical cyclones; Hurricanes; Risk assessment ID MODEL; WIND AB In response to the 2004 and 2005 hurricane seasons, surge risk assessment approaches have been re-evaluated to develop more rapid, reliable methods for predicting the risk associated with extreme hurricanes. Here, the development of dimensionless surge response functions relating surge to hurricane meteorological parameters is presented. Such response functions present an opportunity to maximize surge data usage and to improve statistical estimates of surge probability by providing a means for defining continuous probability density functions. A numerical modeling investigation was carried out for the Texas, USA coastline to develop physical scaling laws relating storm surge response with hurricane parameters including storm size, intensity, and track. It will be shown that these scaling laws successfully estimate the surge response at any arbitrary location for any arbitrary storm track within the study region. Such a prediction methodology has the potential to decrease numerical computation requirements by 75% for hurricane risk assessment studies. C1 [Irish, Jennifer L.] Texas A&M Univ, Zachry Dept Civil Engn, Coastal & Ocean Engn Div, College Stn, TX 77843 USA. [Resio, Donald T.; Cialone, Mary A.] USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39186 USA. RP Irish, JL (reprint author), Texas A&M Univ, Zachry Dept Civil Engn, Coastal & Ocean Engn Div, College Stn, TX 77843 USA. EM jirish@civil.tamu.edu OI Irish, Jennifer/0000-0002-2429-5953 FU U.S. Army Engineer Research and Development Center; National Oceanic and Atmospheric Administration FX The research presented herein was funded by the U.S. Army Engineer Research and Development Center and in part by a Grant/Cooperative Agreement from the National Oceanic and Atmospheric Administration. The views expressed herein are those of the authors and do not necessarily reflect views of NOAA or any of its subagencies. The use of trade names does not constitute an endorsement in the use of these products by the U.S. Government. NR 10 TC 27 Z9 27 U1 0 U2 8 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0921-030X J9 NAT HAZARDS JI Nat. Hazards PD OCT PY 2009 VL 51 IS 1 BP 183 EP 205 DI 10.1007/s11069-009-9381-4 PG 23 WC Geosciences, Multidisciplinary; Meteorology & Atmospheric Sciences; Water Resources SC Geology; Meteorology & Atmospheric Sciences; Water Resources GA 490VG UT WOS:000269535200012 ER PT J AU Wamsley, TV Cialone, MA Smith, JM Ebersole, BA Grzegorzewski, AS AF Wamsley, Ty V. Cialone, Mary A. Smith, Jane M. Ebersole, Bruce A. Grzegorzewski, Alison S. TI Influence of landscape restoration and degradation on storm surge and waves in southern Louisiana SO NATURAL HAZARDS LA English DT Article DE Hurricane; Storm surge; Waves; Wetlands; Restoration; Degradation; Impacts ID SURFACE WIND FIELDS AB The purpose of this investigation was to examine storm surge and wave reduction benefits of different environmental restoration features (marsh restoration and barrier island changes), as well as the impact of future wetland degradation on local surge and wave conditions. Storm surge simulations of two representative hurricanes were performed using the ADCIRC storm surge model with the inclusion of radiation stress gradients from the STWAVE nearshore wave model. Coupled model simulations were made for a number of landscape configurations that involved both restored and degraded wetland features. The impact of barrier island condition on hurricane surge and waves was also evaluated. Effects of landscape features were represented by changes in elevation and frictional resistance. Restoration and degradation of marsh resulted in decreases (for restoration cases) and increases (for degradation cases) in both surge and waves. The magnitude of change was correlated with the magnitude of the horizontal extent and elevation changes in the marsh. In general, the wave change patterns are consistent with the water level changes. Deflation of the Chandeleur Islands (barrier island chain) resulted in slightly increased surge. Results suggest that coastal marsh does have surge and wave reduction potential. Results also indicate that the impact of the landscape features is amplified in areas where there are levee "pockets." Barrier islands and coastal ridges reduce wave heights, even if in a degraded condition and thus can reduce wave energy in wetland areas, protecting them from erosion. C1 [Wamsley, Ty V.; Cialone, Mary A.; Smith, Jane M.; Ebersole, Bruce A.; Grzegorzewski, Alison S.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Wamsley, TV (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Ty.V.Wamsley@usace.army.mil; Mary.A.Cialone@usace.army.mil; Jane.M.Smith@usace.army.mil; Bruce.A.Ebersole@usace.army.mil; Alison.S.Grzegorzewski@usace.army.mil FU Louisiana Coastal Area Science and Technology Program FX This work was performed as part of a study supported by the U. S. Army Engineer District, New Orleans, with additional support provided by the Louisiana Coastal Area Science and Technology Program and the MOdeling Relevant PHysics Of Systems (MORPHOS) Work Unit of the Flood and Coastal Research Program, U. S. Army Corps of Engineers. NR 20 TC 28 Z9 28 U1 6 U2 25 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0921-030X J9 NAT HAZARDS JI Nat. Hazards PD OCT PY 2009 VL 51 IS 1 BP 207 EP 224 DI 10.1007/s11069-009-9378-z PG 18 WC Geosciences, Multidisciplinary; Meteorology & Atmospheric Sciences; Water Resources SC Geology; Meteorology & Atmospheric Sciences; Water Resources GA 490VG UT WOS:000269535200013 ER PT J AU Urban, TJ Weintrob, AC Fellay, J Colombo, S Shianna, KV Gumbs, C Rotger, M Pelak, K Dang, KK Detels, R Martinson, JJ O'Brien, SJ Letvin, NL McMichael, AJ Haynes, BF Carrington, M Telenti, A Michael, NL Goldstein, DB AF Urban, Thomas J. Weintrob, Amy C. Fellay, Jacques Colombo, Sara Shianna, Kevin V. Gumbs, Curtis Rotger, Margalida Pelak, Kimberly Dang, Kristen K. Detels, Roger Martinson, Jeremy J. O'Brien, Stephen J. Letvin, Norman L. McMichael, Andrew J. Haynes, Barton F. Carrington, Mary Telenti, Amalio Michael, Nelson L. Goldstein, David B. TI CCL3L1 and HIV/AIDS susceptibility SO NATURE MEDICINE LA English DT Letter ID GENE COPY NUMBER; HIV-1-INFECTED INDIVIDUALS; HIV-1 INFECTION; CHEMOKINE; ASSOCIATION; MIP-1-ALPHA; ACCURATE C1 [Urban, Thomas J.; Fellay, Jacques; Gumbs, Curtis; Pelak, Kimberly; Dang, Kristen K.; Goldstein, David B.] Duke Univ, Duke Inst Genome Sci & Policy, Ctr Human Genome Variat, Durham, NC 27706 USA. [Weintrob, Amy C.] Walter Reed Army Med Ctr, Infect Dis Clin Res Program, Washington, DC 20307 USA. [Colombo, Sara; Rotger, Margalida; Telenti, Amalio] Univ Hosp Ctr, Inst Microbiol, Lausanne, Switzerland. [Colombo, Sara; Rotger, Margalida; Telenti, Amalio] Univ Lausanne, Lausanne, Switzerland. [Detels, Roger] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA. [Martinson, Jeremy J.] Univ Pittsburgh, Dept Infect Dis & Microbiol, Pittsburgh, PA USA. [O'Brien, Stephen J.] NCI, Lab Genom Divers, Frederick, MD 21701 USA. [Letvin, Norman L.] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Viral Pathogenesis, Boston, MA USA. [McMichael, Andrew J.] John Radcliffe Hosp, Weatherall Inst Mol Med, Human Immunol Unit, MRC, Oxford OX3 9DU, England. [Haynes, Barton F.] Duke Univ, Duke Human Vaccine Inst, Durham, NC USA. [Carrington, Mary] NCI, SAIC Frederick Inc, Expt Immunol Lab, Canc & Inflammat Program, Frederick, MD 21701 USA. [Michael, Nelson L.] US Mil HIV Res Program, Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD USA. RP Urban, TJ (reprint author), Duke Univ, Duke Inst Genome Sci & Policy, Ctr Human Genome Variat, Durham, NC 27706 USA. EM d.goldstein@duke.edu RI SHCS, all/G-4072-2011; SHCS, int. coll. A/G-4083-2011; Fellay, Jacques/A-6681-2009; OI Fellay, Jacques/0000-0002-8240-939X; Martinson, Jeremy/0000-0003-4673-7238 FU Medical Research Council [MC_U137884177]; NCI NIH HHS [N01-CO-12400, N01CO12400]; NIAID NIH HHS [U19 AI067854, U19 AI067854-05] NR 13 TC 44 Z9 44 U1 1 U2 10 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1078-8956 J9 NAT MED JI Nat. Med. PD OCT PY 2009 VL 15 IS 10 BP 1110 EP 1112 DI 10.1038/nm1009-1110 PG 3 WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental Medicine GA 504EC UT WOS:000270596400012 PM 19812560 ER PT J AU He, WJ Kulkarni, H Castiblanco, J Shimizu, C Aluyen, U Maldonado, R Carrillo, A Griffin, M Lipsitt, A Beachy, L Shostakovich-Koretskaya, L Mangano, A Sen, L Nibbs, RJB Tiemessen, CT Bolivar, H Bamshad, MJ Clark, RA Burns, JC Dolan, MJ Ahuja, SK AF He, Weijing Kulkarni, Hemant Castiblanco, John Shimizu, Chisato Aluyen, Una Maldonado, Robert Carrillo, Andrew Griffin, Madeline Lipsitt, Amanda Beachy, Lisa Shostakovich-Koretskaya, Ludmila Mangano, Andrea Sen, Luisa Nibbs, Robert J. B. Tiemessen, Caroline T. Bolivar, Hector Bamshad, Michael J. Clark, Robert A. Burns, Jane C. Dolan, Matthew J. Ahuja, Sunil K. TI Experimental aspects of copy number variant assays at CCL3L1 Reply SO NATURE MEDICINE LA English DT Letter ID ACTIVE ANTIRETROVIRAL THERAPY; GENE; SUSCEPTIBILITY C1 [He, Weijing; Kulkarni, Hemant; Castiblanco, John; Aluyen, Una; Maldonado, Robert; Carrillo, Andrew; Griffin, Madeline; Lipsitt, Amanda; Beachy, Lisa; Clark, Robert A.; Ahuja, Sunil K.] S Texas Vet Hlth Care Syst, Vet Adm Res Ctr AIDS & HIV Infect 1, San Antonio, TX USA. [He, Weijing; Kulkarni, Hemant; Castiblanco, John; Aluyen, Una; Maldonado, Robert; Carrillo, Andrew; Griffin, Madeline; Lipsitt, Amanda; Beachy, Lisa; Clark, Robert A.; Ahuja, Sunil K.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA. [Shimizu, Chisato; Burns, Jane C.] Univ Calif San Diego, Sch Med, Dept Pediat, La Jolla, CA 92093 USA. [Shostakovich-Koretskaya, Ludmila] Dnepropetrovsk State Med Acad, Dept Gen Pediat & Pediat Infect Dis, Dnepropetrovsk, Ukraine. [Mangano, Andrea; Sen, Luisa] Hosp Pediat JP Garrahan, Lab Biol Celular & Retrovirus, Buenos Aires, DF, Argentina. [Nibbs, Robert J. B.] Univ Glasgow, Glasgow Biomed Res Ctr, Glasgow, Lanark, Scotland. [Tiemessen, Caroline T.] Natl Hlth Lab Serv, Natl Inst Communicable Diseases, AIDS Virus Res Unit, Johannesburg, South Africa. [Tiemessen, Caroline T.] Univ Witwatersrand, Johannesburg, South Africa. [Bolivar, Hector] Univ Miami, Miller Sch Med, AIDS Clin Res Unit, Miami, FL 33136 USA. [Bamshad, Michael J.] Univ Washington, Dept Pediat, Seattle, WA 98195 USA. [Bamshad, Michael J.] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA. [Bamshad, Michael J.] Seattle Childrens Hosp, Seattle, WA USA. [Dolan, Matthew J.] Wilford Hall USAF Med Ctr, Henry M Jackson Fdn, Lackland AFB, TX 78236 USA. [Dolan, Matthew J.] Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. RP He, WJ (reprint author), S Texas Vet Hlth Care Syst, Vet Adm Res Ctr AIDS & HIV Infect 1, San Antonio, TX USA. EM ahujas@uthscsa.edu RI CASTIBLANCO, JOHN/B-6599-2009; Shimizu, Chisato/J-6516-2015 OI CASTIBLANCO, JOHN/0000-0002-7965-9822; NR 18 TC 22 Z9 22 U1 0 U2 3 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1078-8956 J9 NAT MED JI Nat. Med. PD OCT PY 2009 VL 15 IS 10 BP 1117 EP 1120 DI 10.1038/nm1009-1117 PG 5 WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental Medicine GA 504EC UT WOS:000270596400015 PM 19812563 ER PT J AU Yuan, CM Jindal, RM Abbott, KC AF Yuan, Christina M. Jindal, Rahul M. Abbott, Kevin C. TI Observation time after kidney biopsy: when to discharge? SO NATURE REVIEWS NEPHROLOGY LA English DT Editorial Material ID PERCUTANEOUS RENAL BIOPSY; COMPLICATIONS AB How long should we monitor patients for evidence of significant bleeding after percutaneous native kidney biopsy? both cost and safety must be rigorously considered before recommending a new standard of care. C1 [Abbott, Kevin C.] Walter Reed Army Med Ctr, Dept Med, Serv Nephrol, Nephrol SVC, Washington, DC 20307 USA. [Jindal, Rahul M.] Walter Reed Army Med Ctr, Organ Transplant Serv, Washington, DC 20307 USA. RP Abbott, KC (reprint author), Walter Reed Army Med Ctr, Dept Med, Serv Nephrol, Nephrol SVC, Washington, DC 20307 USA. EM kevin.abbott@us.army.mil NR 10 TC 3 Z9 3 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1759-5061 J9 NAT REV NEPHROL JI Nat. Rev. Nephrol. PD OCT PY 2009 VL 5 IS 10 BP 552 EP 554 DI 10.1038/nrneph.2009.147 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA 498SN UT WOS:000270163600003 PM 19776772 ER PT J AU Sloan, SD Steeples, DW Tsoflias, GP AF Sloan, Steven D. Steeples, Don W. Tsoflias, Georgios P. TI Ultra-shallow imaging using 3D seismic-reflection methods SO NEAR SURFACE GEOPHYSICS LA English DT Article ID DENSE GEOPHONE ARRAY; NORMAL-MOVEOUT; DEPTH CHARACTERIZATION; BEDROCK SURFACE; ACQUISITION; SEDIMENTS; AQUIFERS; ALLUVIUM AB Three-dimensional ultra-shallow seismic reflection methods were used to image multiple reflectors less than 20 m deep, including the top of saturated zone, a paleo-channel feature and the top of bedrock at a field site located near Lawrence, Kansas. A small 3D demonstration survey was designed and acquired using source and receiver intervals of 0.5 m and source line and receiver line intervals of 2 m. The survey had a nominal fold of 48 and covered an area of similar to 15.5 m x 35.5 m. Large variations in velocity were present, ranging from similar to 300-600 m/s laterally in the shallowest layer and similar to 300-1600 m/s vertically, a degree of variability that is not uncommon in the ultra-shallow subsurface. Normal moveout corrections cannot account for intersecting reflection hyperbolae such as those caused by large vertical velocity gradients, so a novel processing scheme was applied by extracting offset-dependent subsets based on the optimum window for each reflection. The subsets were normal moveout corrected independently and then stacked together using conventional 3D processing techniques. Despite the large lateral and vertical velocity variations, we were successful in imaging the top of the saturated zone, paleo-channel features and the overburden-bedrock interface located at depths of similar to 5 m, 8 m and 14 m, respectively. Results of the 3D survey are in agreement with previous studies conducted at the site. The methods presented here could be applied to situations where 3D imaging of the ultra-shallow subsurface is necessary and may help to identify possible contaminant sinks or flowpaths. C1 [Sloan, Steven D.] USA, Engineer Res & Dev Ctr, CEERD GS S, Vicksburg, MS 39180 USA. [Steeples, Don W.; Tsoflias, Georgios P.] Univ Kansas, Dept Geol, Lawrence, KS 66045 USA. RP Sloan, SD (reprint author), USA, Engineer Res & Dev Ctr, CEERD GS S, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM steven.d.sloan@usace.army.mil FU US Department of Energy [DE-FG02-03ER63656] FX The authors would like to thank the KU Spring 2005 Near-Surface Seismology class for their time in the field, Sally Hayden for editorial assistance and the reviewers for their helpful suggestions. This research was supported by the Office of Science (BER), US Department of Energy, grant DE-FG02-03ER63656. However, any opinions, conclusions, or recommendations expressed herein are those of the authors and do not necessarily reflect the views of the DOE. NR 23 TC 3 Z9 3 U1 0 U2 2 PU EUROPEAN ASSOC GEOSCIENTISTS & ENGINEERS PI 3990 DB, HOUTEN PA PO BOX 59, 3990 DB, HOUTEN, 00000, NETHERLANDS SN 1569-4445 J9 NEAR SURF GEOPHYS JI Near Surf. Geophys. PD OCT-DEC PY 2009 VL 7 IS 5-6 BP 307 EP 314 PG 8 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 507ZI UT WOS:000270895200002 ER PT J AU Fischer, JR AF Fischer, John R. TI The Law of Diminishing Returns? More Surgery Is Not Always Better SO OBSTETRICS AND GYNECOLOGY LA English DT Editorial Material C1 Walter Reed Army Med Ctr, Uniformed Serv Residency Obstet & Gynecology, Bethesda, MD USA. RP Fischer, JR (reprint author), Walter Reed Army Med Ctr, Uniformed Serv Residency Obstet & Gynecology, Bethesda, MD USA. EM john.fischer@amedd.army.mil NR 3 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD OCT PY 2009 VL 114 IS 4 BP 718 EP 719 PG 2 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 503WY UT WOS:000270573800002 PM 19888026 ER PT J AU Arslan, SY Leung, KP Wu, CD AF Arslan, S. Y. Leung, K. P. Wu, C. D. TI The effect of lactoferrin on oral bacterial attachment SO ORAL MICROBIOLOGY AND IMMUNOLOGY LA English DT Article DE iron; iron chelator; lactoferrin; oral bacterial attachment; oral biofilm ID BIOFILM FORMATION; STREPTOCOCCUS-GORDONII; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; PORPHYROMONAS-GINGIVALIS; STAPHYLOCOCCUS-AUREUS; DENTAL PLAQUE; IRON; PROTEINS; SURFACE; MILK AB Introduction: Lactoferrin (Lf), an iron-binding salivary glycoprotein, plays an important role in human innate defense against local mucosal infection. We hypothesized that Lf interferes with initial oral bacterial attachment to surfaces by iron sequestration, so inhibiting subsequent biofilm formation. The objective was to investigate the effect of Lf on the early stages of single-species and multi-species oral biofilm development. Methods: Streptococcus gordonii, Streptococcus mutans, Fusobacterium nucleatum and Porphyromonas gingivalis were used in this study. Glass disks of a two-track flow cell coated with flowing artificial saliva (0.3 ml/min) with and without Lf (100 mu g/ml) were used for studying bacterial attachment (3 h, 37 degrees C). Attachment was also examined by incubating single or multiple species of test bacteria (10(7) colony-forming units/ml) with Lf-coated (20-100 mu g/ml) and uncoated glass slides. The effects of beta-lactoglobulin, 2,2'-dipyridyl (25-100 mu g/ml), an iron chelator, and FeCl(3) on attachment were also examined. Results: Lf inhibited the initial attachment of S. gordonii (50.3%, P < 0.05) but not that of F. nucleatum and P. gingivalis. However, the attachment of a dual-species biofilm containing S. gordonii (i.e. S. gordonii/F. nucleatum or S. gordonii/P. gingivalis) was significantly reduced (48.7% or 62.1%, respectively, P < 0.05) in the presence of Lf. beta-Lactoglobulin did not affect the attachment of S. gordonii. In the presence of 100 mu m 2,2'-dipyridyl, attachment of S. gordonii was reduced by 53.87%. No reduction in attachment was noted in S. gordonii pretreated with Lf (100 mu g/ml) and FeCl(3) (20-200 mu m). Conclusion: Lf suppresses initial attachment of S. gordonii and S. gordonii coaggregates by iron sequestration. This may lead to subsequent inhibition of oral biofilm development. C1 [Arslan, S. Y.; Wu, C. D.] Univ Illinois, Dept Pediat Dent, Coll Dent, Chicago, IL 60612 USA. [Leung, K. P.] US Army Dent Trauma Res Detachment, Great Lakes, IL USA. RP Wu, CD (reprint author), Univ Illinois, Dept Pediat Dent, Coll Dent, MC850,801 S Paulina St,Room 469J, Chicago, IL 60612 USA. EM chriswu@uic.edu FU US Army Medical Research and Materiel Command FX This work was supported by the US Army Medical Research and Materiel Command. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Army, the Department of Defense, or the US Government. The authors thank Dr Xu Xin and Habiba Sultana for their assistance in the qRT-PCR studies. NR 37 TC 25 Z9 28 U1 0 U2 5 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0902-0055 J9 ORAL MICROBIOL IMMUN JI Oral Microbiol. Immunol. PD OCT PY 2009 VL 24 IS 5 BP 411 EP 416 PG 6 WC Dentistry, Oral Surgery & Medicine; Immunology; Microbiology SC Dentistry, Oral Surgery & Medicine; Immunology; Microbiology GA 484PK UT WOS:000269058500010 PM 19702956 ER PT J AU Vogelgesang, GR Lester, PB AF Vogelgesang, Gretchen R. Lester, Paul B. TI Transparency: How Leaders Can Get Results by Laying it on the Line SO ORGANIZATIONAL DYNAMICS LA English DT Article C1 [Vogelgesang, Gretchen R.] George Mason Univ, Sch Management, Fairfax, VA 22030 USA. [Lester, Paul B.] USA, Comprehens Soldier Fitness Off, Arlington, VA USA. RP Vogelgesang, GR (reprint author), George Mason Univ, Sch Management, 4400 Univ Dr,MS 1B1, Fairfax, VA 22030 USA. EM gvogelge@gmail.com; paul.lester@us.army.mil NR 9 TC 6 Z9 6 U1 0 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-2616 J9 ORGAN DYN JI Organ. Dyn. PD OCT-DEC PY 2009 VL 38 IS 4 BP 252 EP 260 DI 10.1016/j.orgdyn.2009.07.003 PG 9 WC Business; Psychology, Applied; Management SC Business & Economics; Psychology GA 522IO UT WOS:000271991300002 ER PT J AU Carr, JB Williams, D Richards, M AF Carr, James B. Williams, Daniel Richards, Mike TI Lateral Decubitus Positioning for Intramedullary Nailing of the Femur Without the Use of a Fracture Table SO ORTHOPEDICS LA English DT Article ID FEMORAL FRACTURES; MANUAL TRACTION AB In closed intramedullary nailing of the femur in the lateral decubitus position without the use of a fracture table, access to the proximal femur is enhanced as compared to Supine nailing, especially in large patients. The hip is typically flexed during the nailing, which allows the nail to be placed posterior to the gluteus medius, thus minimizing abductor damage. The deforming forces of flexion and abduction in proximal fracture patterns can be readily overcome by this technique. Proper rotation of the leg call be assessed clinically or with the use of a femoral neck anteversion guide wire. Fluoroscopic visualization of the proximal femur is excellent, including the femoral head, thus facilitating reconstruction nailing. C1 [Carr, James B.] Lewis Gale Orthoped Surg, Salem, VA USA. [Williams, Daniel] USA, Dept Orthoped, Augusta, GA USA. [Richards, Mike] Premier Orthoped Specialists, Columbia, SC USA. RP Carr, JB (reprint author), 1802 Braeburn Dr, Roanoke, VA 24153 USA. NR 19 TC 4 Z9 6 U1 0 U2 1 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0147-7447 J9 ORTHOPEDICS JI Orthopedics PD OCT PY 2009 VL 32 IS 10 BP 721 EP 724 DI 10.3928/01477447-20090818-05 PG 4 WC Orthopedics SC Orthopedics GA 505JC UT WOS:000270688500006 ER PT J AU Richards, A Mao, CY Dobson, NR AF Richards, Autumn Mao, Chad Y. Dobson, Nicole R. TI Left Ventricular Noncompaction: A Rare Cause of Hydrops Fetalis SO PEDIATRIC CARDIOLOGY LA English DT Article DE Ventricular noncompaction; Cardiomyopathy; Hydrops fetalis; Newborn ID DILATED CARDIOMYOPATHY; NON-COMPACTION; MYOCARDIUM; CLASSIFICATION; MUTATIONS AB We present a case of isolated left ventricular noncompaction (LVNC), a severe congenital cardiomyopathy, which presented in the neonatal period as fetal hydrops. To our knowledge, this is the first child with LVNC presenting with hydrops fetalis to survive infancy. Once considered a uniformly fatal and extremely rare form of cardiomyopathy, LVNC has recently been shown to be more common than previously reported, with a varying range of clinical severity. Although long-term morbidity and mortality are not clearly known, recent work suggests better survivability than once reported. C1 [Dobson, Nicole R.] Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. [Richards, Autumn] Natl Naval Med Ctr, Natl Capital Consortium, Pediat Residency Program, Bethesda, MD USA. [Mao, Chad Y.] Natl Naval Med Ctr, Dept Pediat, Bethesda, MD USA. RP Dobson, NR (reprint author), Walter Reed Army Med Ctr, Dept Pediat, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM ndobson@usuhs.mil NR 12 TC 7 Z9 7 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0172-0643 J9 PEDIATR CARDIOL JI Pediatr. Cardiol. PD OCT PY 2009 VL 30 IS 7 BP 985 EP 988 DI 10.1007/s00246-009-9465-7 PG 4 WC Cardiac & Cardiovascular Systems; Pediatrics SC Cardiovascular System & Cardiology; Pediatrics GA 498ZR UT WOS:000270186200018 PM 19506938 ER PT J AU Killgore, WDS Lipizzi, EL Grugle, NL Killgore, DB AF Killgore, William D. S. Lipizzi, Erica L. Grugle, Nancy L. Killgore, Desiree B. TI HANDEDNESS CORRELATES WITH ACTIGRAPHICALLY MEASURED SLEEP IN A CONTROLLED ENVIRONMENT SO PERCEPTUAL AND MOTOR SKILLS LA English DT Article ID DEPRIVATION; DEXTROAMPHETAMINE; IDENTIFICATION; PERFORMANCE; MODAFINIL; CAFFEINE AB The relationship between hand preference and duration of sleep was assessed in 40 healthy subjects using self-report estimates, sleep diaries, and wrist activity monitors during an uncontrolled 7-day at-home phase and during a controlled overnight stay in a sleep laboratory. Handedness was unrelated to any index of sleep duration when assessed in the unregulated home environment. In the controlled environment of the laboratory, however, greater right-hand dominance was positively correlated with more minutes of obtained sleep and greater sleep efficiency. Findings were consistent with previous reports which suggest measures of brain lateralization may be related to sleep and health but further suggest that these relationships may be easily obscured by extraneous environmental factors when assessed in an uncontrolled setting. C1 [Killgore, William D. S.] Harvard Univ, Sch Med, Walter Reed Army Inst Res, Belmont, MA 02478 USA. RP Killgore, WDS (reprint author), Harvard Univ, Sch Med, McLean Hosp, Neuroimaging Ctr, 115 Mill St, Belmont, MA 02478 USA. EM killgore@mclean.harvard.edu OI Killgore, William/0000-0002-5328-0208 NR 19 TC 1 Z9 1 U1 1 U2 2 PU AMMONS SCIENTIFIC, LTD PI MISSOULA PA PO BOX 9229, MISSOULA, MT 59807-9229 USA SN 0031-5125 J9 PERCEPT MOTOR SKILL JI Percept. Mot. Skills PD OCT PY 2009 VL 109 IS 2 BP 395 EP 400 DI 10.2466/PMS.109.2.395-400 PG 6 WC Psychology, Experimental SC Psychology GA 522IF UT WOS:000271990400008 PM 20037993 ER PT J AU Feczer, D Bjorklund, P AF Feczer, Diana Bjorklund, Pamela TI Forever Changed: Posttraumatic Stress Disorder in Female Military Veterans, A Case Report SO PERSPECTIVES IN PSYCHIATRIC CARE LA English DT Article DE Female veterans; Iraq War; military nurses; OEF; OIF; PTSD ID MENTAL-HEALTH PROBLEMS; MALE VIETNAM VETERANS; CLINICAL RELEVANCE; COMBAT VETERANS; PTSD SYMPTOMS; PRIMARY-CARE; LIFE EVENTS; RESILIENCE; TRAUMA; IRAQ AB PURPOSE. This paper examines the experience of posttraumatic stress disorder (PTSD) in a female veteran of Operation Iraqi Freedom, including the barriers to treatment she encountered in an outpatient psychiatry clinic. DESIGN AND METHODS. Case report data were obtained through review of records and interviews with a veteran combat nurse diagnosed with chronic PTSD. CONCLUSIONS. Sex differences in PTSD are controversial, but PTSD in female military veterans is a significant problem. Gender may complicate diagnosis and treatment. This case report discusses these issues and invites further research. PRACTICE IMPLICATIONS. Advanced practice psychiatric nurses increasingly will see female veterans with PTSD in their practices. C1 [Feczer, Diana] US Army Reserve, Sauk Rapids, MN USA. [Bjorklund, Pamela] Coll St Scholastica, Dept Grad Nursing, Duluth, MN USA. RP Feczer, D (reprint author), US Army Reserve, Sauk Rapids, MN USA. EM feczer@yahoo.com NR 94 TC 4 Z9 4 U1 2 U2 7 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0031-5990 J9 PERSPECT PSYCHIATR C JI Perspect. Psychiatr. Care PD OCT PY 2009 VL 45 IS 4 BP 278 EP 291 PG 14 WC Nursing; Psychiatry SC Nursing; Psychiatry GA 498YL UT WOS:000270182400005 PM 19781000 ER PT J AU Grigolini, P Aquino, G Bologna, M Lukovic, M West, BJ AF Grigolini, Paolo Aquino, Gerardo Bologna, Mauro Lukovic, Mirko West, Bruce J. TI A theory of 1/f noise in human cognition SO PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS LA English DT Article DE Decision making; 1/f noise; Task difficulty ID LONG-RANGE CORRELATIONS; DRIP PAINTINGS; TIME-SERIES; 1-F NOISE; FLUCTUATIONS; MODELS; MUSIC; SYNCHRONIZATION; PSYCHOPHYSICS; EQUILIBRIUM AB The brain is probably the most interesting example of a complex network having 1/f variability as determined through the analysis of EEG time series and magnetoencephalogram recordings. Herein we develop a theory of 1/f noise of human cognition to explain the recent experimental observations that increasing the difficultly of cognitive tasks accelerates the transition from observed 1/f noise to white noise in decision-making time series. (C) 2009 Elsevier B.V. All rights reserved. C1 [Lukovic, Mirko] Univ Pisa, Dipartimento Fis E Fermi, I-56127 Pisa, Italy. [Lukovic, Mirko] INFM, I-56127 Pisa, Italy. [West, Bruce J.] USA, Res Off, Div Math, Durham, NC 27709 USA. [Bologna, Mauro] Univ Tarapaca, Inst Alta Invest, Arica, Chile. [Aquino, Gerardo] Max Planck Inst Phys CompSems, Dresden, Germany. [Grigolini, Paolo] CNR, Ist Proc Chim Fisici, Area Ric Pisa, I-56124 Pisa, Italy. [Grigolini, Paolo; Bologna, Mauro] Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA. RP Lukovic, M (reprint author), Univ Pisa, Dipartimento Fis E Fermi, Stanza 124 C-O Grigolini,Largo Pontecorvo 3, I-56127 Pisa, Italy. EM lukovic@df.unipi.it RI Aquino, Gerardo/C-5529-2008; West, Bruce/E-3944-2017 OI Aquino, Gerardo/0000-0003-3228-7520; FU Welch [B-1577]; [W911NF-08-1-0117] FX We warmly thank two unknown referees for remarks and Suggestions that led LIS to turn the original version into a much richer and more attractive illustration of the cognition origin of 1/f noise. M.B. and P.G. thank ARO (grant W911NF-08-1-0117) and Welch (grant B-1577) for financial Support. NR 68 TC 36 Z9 36 U1 2 U2 19 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-4371 EI 1873-2119 J9 PHYSICA A JI Physica A PD OCT 1 PY 2009 VL 388 IS 19 BP 4192 EP 4204 DI 10.1016/j.physa.2009.06.024 PG 13 WC Physics, Multidisciplinary SC Physics GA 479IW UT WOS:000268653900023 ER PT J AU Roppo, V Cojocaru, C Raineri, F D'Aguanno, G Trull, J Halioua, Y Raj, R Sagnes, I Vilaseca, R Scalora, M AF Roppo, V. Cojocaru, C. Raineri, F. D'Aguanno, G. Trull, J. Halioua, Y. Raj, R. Sagnes, I. Vilaseca, R. Scalora, M. TI Field localization and enhancement of phase-locked second- and third-order harmonic generation in absorbing semiconductor cavities SO PHYSICAL REVIEW A LA English DT Article DE gallium arsenide; III-V semiconductors; optical harmonic generation ID MISMATCHED 2ND-HARMONIC GENERATION; OPTICAL HARMONICS; PULSES; LINBO3; MODULATION; DISPERSION; VELOCITY; LIGHT AB We predict and experimentally observe the enhancement by three orders of magnitude of phase mismatched second and third harmonic generation in a GaAs cavity at 650 and 433 nm, respectively, well above the absorption edge. Phase locking between the pump and the harmonics changes the effective dispersion of the medium and inhibits absorption. Despite hostile conditions the harmonics resonate inside the cavity and become amplified leading to relatively large conversion efficiencies. Field localization thus plays a pivotal role despite the presence of absorption, and ushers in a new class of semiconductor-based devices in the visible and uv ranges. C1 [Roppo, V.; Cojocaru, C.; Trull, J.; Vilaseca, R.] Univ Politecn Cataluna, E-08222 Terrassa, Spain. [Roppo, V.; D'Aguanno, G.; Scalora, M.] USA, Charles M Bowden Res Facil, RDECOM, Redstone Arsenal, AL 35803 USA. [Raineri, F.; Halioua, Y.; Raj, R.; Sagnes, I.] Lab Photon & Nanostruct, F-91460 Marcoussis, France. RP Roppo, V (reprint author), Univ Politecn Cataluna, Colom 11, E-08222 Terrassa, Spain. RI roppo, vito/D-9639-2012; Trull, Jose/L-9054-2014; Raineri, Fabrice/B-2386-2016; OI roppo, vito/0000-0003-0928-4209; Trull, Jose/0000-0002-5850-088X; Vilaseca, Ramon/0000-0002-3736-5789; D'Aguanno, Giuseppe/0000-0002-7132-0103 FU U.S. Army European Research office [W911NF]; National Research Council; Spanish government [FIS2008-06024-C03-02/FIS] FX We thank the U.S. Army European Research office for partial financial support (project W911NF). G. D. thanks the National Research Council for financial support. V. R., C. C., J. T. and R. V. acknowledge support from the Spanish government through Project No. FIS2008-06024-C03-02/FIS. We also thank Nadia Mattiucci and Mark J. Bloemer for helpful discussions and suggestions. NR 26 TC 16 Z9 16 U1 0 U2 2 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD OCT PY 2009 VL 80 IS 4 AR 043834 DI 10.1103/PhysRevA.80.043834 PG 6 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA 513VB UT WOS:000271351000190 ER PT J AU Libraty, DH Acosta, LP Tallo, V Segubre-Mercado, E Bautista, A Potts, JA Jarman, RG Yoon, IK Gibbons, RV Brion, JD Capeding, RZ AF Libraty, Daniel H. Acosta, Luz P. Tallo, Veronica Segubre-Mercado, Edelwisa Bautista, Analisa Potts, James A. Jarman, Richard G. Yoon, In-Kyu Gibbons, Robert V. Brion, Job D. Capeding, Rosario Z. TI A Prospective Nested Case-Control Study of Dengue in Infants: Rethinking and Refining the Antibody-Dependent Enhancement Dengue Hemorrhagic Fever Model SO PLOS MEDICINE LA English DT Article ID VIRUS-INFECTION; IN-VIVO; PATHOGENESIS; SEVERITY; CHILDREN; DISEASE; SAMPLES AB Background: Dengue hemorrhagic fever (DHF) is the severe and life-threatening syndrome that can develop after infection with any one of the four dengue virus (DENV) serotypes. DHF occurs almost exclusively in individuals with secondary heterologous DENV infections and infants with primary DENV infections born to dengue immune mothers. The widely accepted explanation for the pathogenesis of DHF in these settings, particularly during infancy, is antibody-dependent enhancement (ADE) of DENV infection. Methods and Findings: We conducted a prospective nested case-control study of DENV infections during infancy. Clinical data and blood samples were collected from 4,441 mothers and infants in up to two pre-illness study visits, and surveillance was performed for symptomatic and inapparent DENV infections. Pre-illness plasma samples were used to measure the associations between maternally derived anti-DENV3 antibody-neutralizing and -enhancing capacities at the time of DENV3 infection and development of infant DHF. The study captured 60 infants with DENV infections across a wide spectrum of disease severity. DENV3 was the predominant serotype among the infants with symptomatic (35/40) and inapparent (15/20) DENV infections, and 59/60 infants had a primary DENV infection. The estimated in vitro anti-DENV3 neutralizing capacity at birth positively correlated with the age of symptomatic primary DENV3 illness in infants. At the time of symptomatic DENV3 infection, essentially all infants had low anti-DENV3 neutralizing activity (50% plaque reduction neutralizing titers [PRNT(50)] <= 50) and measurable DENV3 ADE activity. The infants who developed DHF did not have significantly higher frequencies or levels of DENV3 ADE activity compared to symptomatic infants without DHF. A higher weight-for-age in the first 3 mo of life and at illness presentation was associated with a greater risk for DHF from a primary DENV infection during infancy. Conclusions: This prospective nested case-control study of primarily DENV3 infections during infancy has shown that infants exhibit a full range of disease severity after primary DENV infections. The results support an initial in vivo protective role for maternally derived antibody, and suggest that a DENV3 PRNT(50) >50 is associated with protection from symptomatic DENV3 illness. We did not find a significant association between DENV3 ADE activity at illness onset and the development of DHF compared with less severe symptomatic illness. The results of this study should encourage rethinking or refinement of the current ADE pathogenesis model for infant DHF and stimulate new directions of research into mechanisms responsible for the development of DHF during infancy. C1 [Libraty, Daniel H.; Potts, James A.] Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA 01605 USA. [Acosta, Luz P.] Res Inst Trop Med, Dept Immunol, Manila, Philippines. [Tallo, Veronica] Res Inst Trop Med, Dept Epidemiol, Manila, Philippines. [Segubre-Mercado, Edelwisa] Res Inst Trop Med, Dept Mol Biol, Manila, Philippines. [Bautista, Analisa] Res Inst Trop Med, Dept Virol, Manila, Philippines. [Jarman, Richard G.; Yoon, In-Kyu; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Brion, Job D.] San Pablo City Hlth Off, San Pablo, Philippines. [Capeding, Rosario Z.] Res Inst Trop Med, Dept Microbiol, Manila, Philippines. [Capeding, Rosario Z.] Res Inst Trop Med, Dept Med, Manila, Philippines. RP Libraty, DH (reprint author), Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA 01605 USA. EM daniel.libraty@umassmed.edu FU National Institutes of Health [U01 AI065654] FX This study was supported by National Institutes of Health grant U01 AI065654. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 32 TC 76 Z9 78 U1 0 U2 14 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1549-1277 J9 PLOS MED JI PLos Med. PD OCT PY 2009 VL 6 IS 10 AR e1000171 DI 10.1371/journal.pmed.1000171 PG 11 WC Medicine, General & Internal SC General & Internal Medicine GA 522XB UT WOS:000272032300014 PM 19859541 ER PT J AU Fitzpatrick, KF AF Fitzpatrick, Kevin F. TI Standard Electrodiagnostic Testing May Be Useful in Diagnosing a Pure Sensory Lumbar Radiculopathy SO PM&R LA English DT Article C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Fitzpatrick, KF (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave, Washington, DC 20307 USA. EM kevin.f.fitzpatrick@us.army.mil NR 11 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1934-1482 J9 PM&R JI PM&R PD OCT PY 2009 VL 1 IS 10 BP 980 EP 982 DI 10.1016/j.pmrj.2009.09.002 PG 3 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA V24LN UT WOS:000208412000018 PM 19854429 ER PT J AU Convertino, VA AF Convertino, Victor A. TI Status of cardiovascular issues related to space flight: Implications for future research directions SO RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY LA English DT Article DE Cardiovascular; Space flights; Cardiac dysrythmias; Orthostatic intolerance ID POSTSPACEFLIGHT ORTHOSTATIC HYPOTENSION; BED-REST; VASCULAR-RESISTANCE; CARDIAC ATROPHY; HEART-RATE; SPACEFLIGHT; MICROGRAVITY; PERFORMANCE; INTOLERANCE; ASTRONAUTS AB Compromised cardiovascular performance, occurrence of serious cardiac dysrhythmias, cardiac atrophy, orthostatic intolerance, reduced aerobic capacity, operational impacts of regular physical exercise, and space radiation are risks of space flight to the cardiovascular system identified in the 2007 NASA Human Integrated Research Program. An evidence-based approach to identify the research priorities needed to resolve those cardiovascular risks that could most likely compromise the successful completion of extended-duration space missions is presented. Based on data obtained from astronauts who have flown in space, there is no compelling experimental evidence to support significant occurrence of autonomic or vascular dysfunction, cardiac dysrhythmias, or manifestation of asymptomatic cardiovascular disease. The operational impact of prolonged daily exercise and space radiation needs to be defined. In contrast, data from the literature support the notion that the highest probability of occurrence and operational impact with space flight involving cardiovascular risks to astronaut health, safety and operational performance are reduced orthostatic tolerance and aerobic capacity, the resource cost of effective countermeasures, and the potential effects of space radiation. Future research should focus on these challenges. Published by Elsevier B.V. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Convertino, VA (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM victor.convertino@amedd.army.mil NR 26 TC 15 Z9 18 U1 3 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1569-9048 J9 RESP PHYSIOL NEUROBI JI Respir. Physiol. Neuro. PD OCT PY 2009 VL 169 BP S34 EP S37 DI 10.1016/j.resp.2009.04.010 PG 4 WC Physiology; Respiratory System SC Physiology; Respiratory System GA 520LQ UT WOS:000271846300011 PM 19383556 ER PT J AU Bucher, G AF Bucher, Greta TI Stalinism on the Frontier of Empire: Women and State Formation in the Soviet Far East SO RUSSIAN REVIEW LA English DT Book Review C1 [Bucher, Greta] US Mil Acad, West Point, NY 10996 USA. RP Bucher, G (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0036-0341 J9 RUSS REV JI Russ. Rev. PD OCT PY 2009 VL 68 IS 4 BP 718 EP 718 PG 1 WC History SC History GA 493JI UT WOS:000269732300038 ER PT J AU Egelhoff, WF Pong, PWT Unguris, J McMichael, RD Nowak, ER Edelstein, AS Burnette, JE Fischer, GA AF Egelhoff, W. F., Jr. Pong, P. W. T. Unguris, J. McMichael, R. D. Nowak, E. R. Edelstein, A. S. Burnette, J. E. Fischer, G. A. TI Critical challenges for picoTesla magnetic-tunnel-junction sensors SO SENSORS AND ACTUATORS A-PHYSICAL LA English DT Article DE picoTesla; Magnetic-tunnel-junction; Magnetic sensors; Tunneling magnetoresistance ID NOISE AB The extension of small, inexpensive, low-power, low-frequency, ultra-sensitive magnetic sensors to fields between 1 nT and 1 pT, an area currently dominated by fluxgates, optically pumped magnetometers, and SQUIDS, would be a paradigm shift for the field of magnetic sensors. The necessary elements for picoTesla magnetic-tunnel-junction (MTJ) sensors have been identified by modeling the noise characteristics. The results help identify the experimental challenges involved in the integration of these necessary elements into actual sensors, illustrate the trade-offs faced if there are losses in performance upon integration. Scanning electron microscopy with polarization analysis (SEMPA) of the pinned layer provides insights into problems and possible solutions. Issues associated with real-world applications of these sensors to ultra-low field measurements are discussed. (C) 2009 Published by Elsevier B.V. C1 [Egelhoff, W. F., Jr.; Pong, P. W. T.] NIST, Div Met, Gaithersburg, MD 20899 USA. [Unguris, J.; McMichael, R. D.] NIST, Ctr Nanoscale Sci & Technol, Gaithersburg, MD 20899 USA. [Nowak, E. R.] Univ Delaware, Dept Phys & Astron, Newark, DE 19716 USA. [Edelstein, A. S.; Burnette, J. E.; Fischer, G. A.] USA, Res Lab, Adelphi, MD 20783 USA. RP Pong, PWT (reprint author), Univ Hong Kong, Dept Elect & Elect Engn, Pokfulam Rd, Hong Kong, Hong Kong, Peoples R China. EM ppong@eee.hku.hk RI McMichael, Robert/J-8688-2012; Unguris, John/J-3989-2014; OI McMichael, Robert/0000-0002-1372-664X FU ONR [N00014-07-C-0355]; DOE [DE-FG02-07ER46374] FX One of us (ASE) would like to acknowledge valuable discussions on MEMS flux concentrators with Neil Smith (then) of IBM. E.R.N. acknowledges support from ONR under STTR award N00014-07-C-0355 and DOE under award DE-FG02-07ER46374. The authors would like to acknowledge valuable assistance and discussions on various aspects of this work with: Roger Koch, Neil Smith (HGST), Bill Doyle, Mark Stiles, Brian Maranville, Moshe Schmoueli, Cindi Dennis, Mike Donahue, Casey Uhlig, John Bonevich, Dave Pappas, Steve Russek, Tom Silva, Mike Donahue, Justin Shaw, P.J. Chen, and Audie Castillo. NR 28 TC 47 Z9 49 U1 4 U2 34 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0924-4247 J9 SENSOR ACTUAT A-PHYS JI Sens. Actuator A-Phys. PD OCT PY 2009 VL 155 IS 2 BP 217 EP 225 DI 10.1016/j.sna.2009.08.016 PG 9 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 521LZ UT WOS:000271924200001 ER PT J AU Rajaraman, S Gribok, AV Wesensten, NJ Balkin, TJ Reifman, J AF Rajaraman, Srinivasan Gribok, Andrei V. Wesensten, Nancy J. Balkin, Thomas J. Reifman, Jaques TI An Improved Methodology for Individualized Performance Prediction of Sleep-Deprived Individuals with the Two-Process Model SO SLEEP LA English DT Article DE Total sleep deprivation; cognitive performance impairment; individualized modeling; parameter estimation; performance prediction ID BIOMATHEMATICAL MODELS; FATIGUE; ALERTNESS; DEPRIVATION; IMPAIRMENT; AMPLITUDE; ISSUES AB We present a method based on the two-process model of sleep regulation for developing individualized biomathematical models that predict performance impairment for individuals subjected to total sleep loss. This new method advances our previous work in two important ways. First, it enables model customization to start as soon as the first performance measurement from an individual becomes available. This was achieved by optimally combining the performance information obtained from the individual's performance measurements with a priori performance information using a Bayesian framework, while retaining the strategy of transforming the nonlinear optimization problem of finding the optimal estimates of the two-process model parameters into a series of linear optimization problems. Second, by taking advantage of the linear representation of the two-process model, this new method enables the analytical computation of statistically based measures of reliability for the model predictions in the form of prediction intervals. Two distinct data sets were used to evaluate the proposed method. Results using simulated data with superimposed white Gaussian noise showed that the new method yielded 50% to 90% improvement in para rameter-estimate accuracy over the previous method. Moreover, the accuracy of the analytically computed prediction intervals was validated through Monte Carlo simulations. Results for subjects representing three sleep-loss phenotypes who participated in a laboratory study (82 h of total sleep loss) indicated that the proposed method yielded individualized predictions that were up to 43% more accurate than group-average prediction models and, on average, 10% more accurate than individualized predictions based on our previous method. C1 [Reifman, Jaques] US Army Med Res & Mat Command, Bioinformat Cell Telemed & Adv Technol Res Ctr, MCMR TT, Ft Detrick, MD 21702 USA. [Wesensten, Nancy J.; Balkin, Thomas J.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD USA. RP Reifman, J (reprint author), US Army Med Res & Mat Command, Bioinformat Cell Telemed & Adv Technol Res Ctr, MCMR TT, Bldg 363 Miller Dr, Ft Detrick, MD 21702 USA. EM jaques.reifman@us.army.mil FU Military Operational Medicine Research Area Directorate of the U.S. Army Medical Research and Materiel Command; Department of Defense High Performance Computing Modernization Program FX This work was funded, in part, by the Military Operational Medicine Research Area Directorate of the U.S. Army Medical Research and Materiel Command, Ft. Detrick, MD. Drs. Rajaraman, Gribok, and Reifman thank the Advanced Biomedical Computing Center at the National Cancer Institute, Frederick, MD, and the U.S. Arrny Research Laboratory DoD supercomputing resource centers, sponsored by the Department of Defense High Performance Computing Modernization Program, for their high-performance computing services. NR 42 TC 12 Z9 12 U1 0 U2 2 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PD OCT 1 PY 2009 VL 32 IS 10 BP 1377 EP 1392 PG 16 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 503TH UT WOS:000270562500016 PM 19848366 ER PT J AU Gottfried, JL Harmon, RS De Lucia, FC Miziolek, AW AF Gottfried, Jennifer L. Harmon, Russell S. De Lucia, Frank C., Jr. Miziolek, Andrzej W. TI Multivariate analysis of laser-induced breakdown spectroscopy chemical signatures for geomaterial classification SO SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY LA English DT Article; Proceedings Paper CT 5th International Conference on Laser-Induced Breakdown Spectroscopy CY SEP 22-26, 2008 CL Berlin, GERMANY SP BAM, Fed Inst Mat Res & Testing, Humboldt Univ Berlin, Inst Analyt Sci DE Laser-induced; breakdown spectroscopy; Chemical signatures; Geomaterial classification; Multivariate analysis ID SENSOR TECHNOLOGY; REAL-TIME; QUANTITATIVE-ANALYSIS; HEAVY-METALS; IRON-ORE; LIBS; PLASMA; SOILS; DISCRIMINATION; EXPLOSIVES AB A large suite of natural carbonate, fluorite and silicate geological materials was studied using laser-induced breakdown spectroscopy (LIBS). Both single- and double-pulse LIBS spectra were acquired using close-contact benchtop and standoff (25 m) LIBS systems. Principal components analysis (PCA) and partial least squares discriminant analysis (PLS-DA) were used to identify the distinguishing characteristics of the geological samples and to classify the materials. Excellent discrimination was achieved with all sample types using PLS-DA and several techniques for improving sample classification were identified. The laboratory double-pulse LIBS system did not provide any advantage for sample classification over the single-pulse LIBS system, except in the case of the soil samples. The standoff LIBS system provided comparable results to the laboratory systems. This work also demonstrates how PCA can be used to identify spectral differences between similar sample types based on minor impurities. Published by Elsevier B.V C1 [Gottfried, Jennifer L.; De Lucia, Frank C., Jr.; Miziolek, Andrzej W.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Harmon, Russell S.] ARL Army Res Off, Res Triangle Pk, NC 27709 USA. RP Gottfried, JL (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM jennifer.gottfried@us.army.mil RI Gottfried, Jennifer/G-6333-2010; De Lucia, Frank/D-5630-2012 NR 40 TC 70 Z9 72 U1 5 U2 30 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0584-8547 J9 SPECTROCHIM ACTA B JI Spectroc. Acta Pt. B-Atom. Spectr. PD OCT PY 2009 VL 64 IS 10 BP 1009 EP 1019 DI 10.1016/j.sab.2009.07.005 PG 11 WC Spectroscopy SC Spectroscopy GA 516MO UT WOS:000271546700012 ER PT J AU Hayden, PJ Petrali, JP Stolper, G Hamilton, TA Jackson, GR Wertz, PW Ito, S Smith, WJ Klausner, M AF Hayden, Patrick J. Petrali, John P. Stolper, Gina Hamilton, Tracey A. Jackson, George R., Jr. Wertz, Philip W. Ito, Susumu Smith, William J. Klausner, Mitchell TI Microvesicating effects of sulfur mustard on an in vitro human skin model SO TOXICOLOGY IN VITRO LA English DT Article DE Sulfur mustard; Chemical warfare agent; Vesicant; Skin blistering; Tissue engineered human skin model; Basement membrane; Apoptosis ID DERMAL-EPIDERMAL JUNCTION; BASEMENT-MEMBRANE; HUMAN KERATINOCYTES; RECONSTRUCTED SKIN; FULL-THICKNESS; VITAMIN-C; ULTRASTRUCTURAL CHARACTERIZATION; PERCUTANEOUS EXPOSURE; CHEMICAL WARFARE; APOPTOSIS AB Bis-(beta-chloroethyl) sulfide (SM) is a potent skin vesicant previously used for chemical warfare. Progress in determination of the mechanistic basis of SM pathology, and development of prophylactic and/or therapeutic countermeasures to SM exposure has been hampered by lack of physiologically relevant models of human skin. The current work evaluated a newly developed tissue engineered full-thickness human skin model in a completely in vitro approach to investigation of SM-induced dermal pathology. The model was first characterized with regard to overall morphology, lipid composition. basement membrane (BM) composition and ultrastructural features that are important targets of SM pathologic activity. Well-developed BM ultrastructural features were observed at the dermal-epidermal junction (DEJ), thus demonstrating successful resolution of a primary deficiency of models previously evaluated for SM studies. Studies were then conducted to evaluate histopathological effects of SM on the model. Good replication in vivo effects was observed, including apoptosis of basal keratinocytes (KC) and microblister formation at the DEJ. Tissue engineered skin models with well-developed basement membrane structures thus appear to be useful tools for in vitro mechanistic studies of SM vesicant activity and development of preventive/therapeutic approaches for SM pathology. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Hayden, Patrick J.; Stolper, Gina; Jackson, George R., Jr.; Klausner, Mitchell] MatTek Corp, Ashland, MA 01721 USA. [Petrali, John P.; Hamilton, Tracey A.; Smith, William J.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Wertz, Philip W.] Univ Iowa, Iowa City, IA USA. [Ito, Susumu] Harvard Univ, Sch Med, Boston, MA USA. RP Hayden, PJ (reprint author), MatTek Corp, 200 Homer Ave, Ashland, MA 01721 USA. EM phayden@mattek.com FU US Department of Defense [DAMD17-00-C-0029] FX This research was funded in part by US Department of Defense Contract No. DAMD17-00-C-0029 to MatTek Corp. NR 60 TC 21 Z9 21 U1 0 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0887-2333 J9 TOXICOL IN VITRO JI Toxicol. Vitro PD OCT PY 2009 VL 23 IS 7 BP 1396 EP 1405 DI 10.1016/j.tiv.2009.07.021 PG 10 WC Toxicology SC Toxicology GA 511NF UT WOS:000271171500026 PM 19619636 ER PT J AU Aidinian, G Fox, CJ White, PW Cox, MW Adams, ED Gillespie, DL AF Aidinian, Gilbert Fox, Charles J. White, Paul W. Cox, Mitchell W. Adams, Eric D. Gillespie, David L. TI Intravascular Ultrasound-Guided Inferior Vena Cava Filter Placement in the Military Multitrauma Patients: A Single-Center Experience SO VASCULAR AND ENDOVASCULAR SURGERY LA English DT Article DE inferior vena cava filter; trauma; intravascular ultrasound ID CRITICALLY-ILL PATIENTS; VENOUS THROMBOEMBOLISM; TRAUMA PATIENTS; INSERTION; BEDSIDE; COMPLICATIONS; COST AB Background: High velocity fragments have resulted in a multitude of complex injuries in the military patients, placing them at increased risk of venous thromboembolism. Methods: A retrospective analysis was performed of all the intravascular ultrasound (IVUS)-guided bedside inferior vena cava (IVC) filters placed between August 2003 and October 2007. Results: Fourteen patients had bedside IVUS-guided retrievable filter placement. Thirteen males and one female and the mean (+SD) injury severity scores (ISS) was 37.2 (+9.9). The most common causes of injury were explosive devices (57%), gunshot wounds (28%), rocket-propelled grenades (7%), and motor vehicle crashes (7%). Indications for filter insertion were deep venous thrombosis in 36% of patients and pulmonary embolus in 28%. Thirty five percent had filters inserted prophylactically. Conclusions: Military trauma population ISS is considerably higher than what is reported in the civilian population. The bedside IVUS-guided IVC filter insertion is particularly useful in this population. C1 [Aidinian, Gilbert; Fox, Charles J.; Cox, Mitchell W.; Adams, Eric D.] Walter Reed Army Med Ctr, Dept Surg, Peripheral Vasc Surg Serv, Washington, DC 20307 USA. [Gillespie, David L.] Univ Rochester, Med Ctr, Dept Vasc Surg, Rochester, NY 14642 USA. [White, Paul W.] Eisenhower Army Med Ctr, Dept Surg, Peripheral Vasc Surg Serv, Augusta, GA USA. RP Aidinian, G (reprint author), Walter Reed Army Med Ctr, Dept Surg, Peripheral Vasc Surg Serv, 6900 Georgia Ave NW,Bldg 2,Ward 64, Washington, DC 20307 USA. EM gilbert.aidinian@us.army.mil OI Gillespie, David/0000-0002-4378-9465 NR 15 TC 6 Z9 7 U1 0 U2 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1538-5744 J9 VASC ENDOVASC SURG JI Vasc. Endovasc. Surg. PD OCT PY 2009 VL 43 IS 5 BP 497 EP 501 DI 10.1177/1538574409334824 PG 5 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 510JQ UT WOS:000271084900013 PM 19640915 ER PT J AU Takhampunya, R Palmer, DR McClain, S Barvir, DA Lynch, J Jarman, RG Thomas, S Gibbons, RV Burgess, TH Sun, PF Kamau, E Putnak, R Zhang, CL AF Takhampunya, Ratree Palmer, Dupeh R. McClain, Sasha Barvir, David A. Lynch, Julia Jarman, Richard G. Thomas, Stephen Gibbons, Robert V. Burgess, Timothy H. Sun, Peifang Kamau, Edwin Putnak, Robert Zhang, Chunlin TI Phenotypic analysis of dengue virus isolates associated with dengue fever and dengue hemorrhagic fever for cellular attachment, replication and interferon signaling ability SO VIRUS RESEARCH LA English DT Article DE Dengue viruses; Interferon; Replication; DF; DHF ID HUMAN DENDRITIC CELLS; DISEASE SEVERITY; ANTIBODY-RESPONSE; TYPE-2 VIRUSES; INFECTION; PATHOGENESIS; THAILAND; ALPHA; ENHANCEMENT; NONINTEGRIN AB Eighteen dengue viruses (DENVs) representing all four serotypes, isolated from pediatric patients at children's hospital, Queen Sirikit National Institute of Child Health, Bangkok, Thailand exhibiting a diverse spectrum of disease ranging from uncomplicated dengue fever (DF) to severe dengue hemorrhagic fever (DHF), were tested for their ability to attach to host cells, replicate and interfere with the IFN alpha signaling pathway by interfering with signal transducer and activator of transcription I (STAT-I) function. Although most isolates suppressed IFN alpha-induced STAT-1 phosphorylation, our results showed no difference between DENV strains associated with DF and those associated with DHF. However, the DHF isolates tended replicate to higher titers in dendritic cells (DCs) than the DF isolates, but this ability was independent of their cell-binding capability. Our results suggest that the emergence early in infection of viruses with a high degree of replication fitness may play an important role in DENV pathogenesis. Published by Elsevier B.V. C1 [Takhampunya, Ratree; Palmer, Dupeh R.; McClain, Sasha; Barvir, David A.; Lynch, Julia; Kamau, Edwin; Putnak, Robert; Zhang, Chunlin] Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD USA. [Jarman, Richard G.; Thomas, Stephen; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Takhampunya, Ratree] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Burgess, Timothy H.; Sun, Peifang] Naval Med Res Ctr, Dept Viral & Rickettsial Dis, Silver Spring, MD USA. RP Zhang, CL (reprint author), Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD USA. EM chunlin.zhang@amedd.army.mil FU National Research Council Research Associateship; Military Infectious Disease Research Program; United States Army Medical Research and Materiel Command, Fort Detrick, MD FX We thank the staff members of the Department of Virology, AFRIMS for collecting, identifying, sequencing and managing the stored samples, the physicians and nurses of Queen Sirikit National Institute of Child Health for sample collection and grading. We thank Dr. Yuxin Tang for helping in critical review. This work was funded by the Military Infectious Disease Research Program and the United States Army Medical Research and Materiel Command, Fort Detrick, MD. The opinions or assertions contained herein are the private views of the authors and are not to be construed as reflecting the official views of the United States Army or the Department of Defense. This research was performed while the author held a National Research Council Research Associateship Award at Department of Virology, WRAIR. NR 40 TC 6 Z9 6 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-1702 J9 VIRUS RES JI Virus Res. PD OCT PY 2009 VL 145 IS 1 BP 31 EP 38 DI 10.1016/j.virusres.2009.05.016 PG 8 WC Virology SC Virology GA 503JY UT WOS:000270531600005 PM 19540887 ER PT J AU Padmanabhan, S Prasad, BM AF Padmanabhan, S. Prasad, B. M. TI SUSTAINED DEPOLARIZATION DECREASES CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE II ACTIVITY AND GENE EXPRESSION IN DOPAMINE NEURONS SO NEUROSCIENCE LA English DT Article DE ERK; PP2A; action potential; transporter; plasticity; BDNF ID LONG-TERM POTENTIATION; TYROSINE-HYDROXYLASE; IN-VIVO; POSTSYNAPTIC DENSITY; PHOSPHATASE 2A; PHOSPHORYLATION; MEMORY; ACTIVATION; BRAIN; TRANSCRIPTION AB Altered gene expression mediated by calcium/calmodulin-dependent protein kinase II (CaMKII) and other intracellular signaling molecules plays an important role in activity-dependent neuroplasticity. We discovered that sustained depolarization induced by KCI, a commonly used paradigm for studying activity-dependent gene expression, surprisingly caused a decrease in CaMKII activity in rat mesencephalic dopamine neurons. This decrease in CaMKII activity, after 2 days of depolarization, occurred in the presence of a continued elevation in intracellular calcium concentration. An increase in calyculin-sensitive phosphatase activity was at least partly responsible for the decrease in CaMKII activity. Phosphatase assays revealed that activity but not the abundance of protein phosphatase-2A was increased by sustained depolarization. Decreased CaMKII activity was accompanied by a selective decrease in dopamine transporter (DAT) mRNA, while tyrosine hydroxylase and actin mRNA abundance was unaltered. On the other hand, brain-derived neurotrophic factor (BDNF) mRNA abundance was increased by sustained depolarization, further demonstrating the specificity of changes. Depolarization also caused a significant decrease in DAT protein abundance and DAT-mediated uptake. Taken together, these data illustrate a novel signaling paradigm in which the activity of protein phosphatase-2A is associated with CaMKII activity and gene expression. Published by Elsevier Ltd on behalf of IBRO. C1 [Prasad, B. M.] Dwight D Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA 30905 USA. [Padmanabhan, S.; Prasad, B. M.] Med Coll Georgia, Dept Pharmacol & Toxicol, Augusta, GA 30912 USA. RP Prasad, BM (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Clin Invest, 38705 7th Ave, Ft Gordon, GA 30905 USA. EM balakrishna.prasad@us.army.mil NR 46 TC 3 Z9 3 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0306-4522 J9 NEUROSCIENCE JI Neuroscience PD SEP 29 PY 2009 VL 163 IS 1 BP 277 EP 285 DI 10.1016/j.neuroscience.2009.06.041 PG 9 WC Neurosciences SC Neurosciences & Neurology GA 489FD UT WOS:000269404600025 PM 19555740 ER PT J AU Hackley, J Ali, D DiPasquale, J Demaree, JD Richardson, CJK AF Hackley, J. Ali, D. DiPasquale, J. Demaree, J. D. Richardson, C. J. K. TI Graphitic carbon growth on Si(111) using solid source molecular beam epitaxy SO APPLIED PHYSICS LETTERS LA English DT Article ID GRAPHENE; FILMS; TEMPERATURE; SI AB Solid source molecular beam epitaxy is used to explore the growth of carbon films directly on Si(111). It is shown that graphitic carbon is grown by the implementation of a thin amorphous carbon film that suppresses the formation of SiC precipitates. Raman scattering measurements show the D and G vibrational phonon modes, indicating graphitic ordering in the carbon film. X-ray photoelectron spectroscopy is used to verify the formation of sp2 bonds in the graphitic carbon films and confirms the suppression of SiC. (C) 2009 American Institute of Physics. [doi:10.1063/1.3242029] C1 [Hackley, J.; Ali, D.; DiPasquale, J.; Richardson, C. J. K.] Lab Phys Sci, College Pk, MD 20740 USA. [Demaree, J. D.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Hackley, J (reprint author), Lab Phys Sci, College Pk, MD 20740 USA. EM jhackley@lps.umd.edu NR 14 TC 62 Z9 63 U1 2 U2 38 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 28 PY 2009 VL 95 IS 13 AR 133114 DI 10.1063/1.3242029 PG 3 WC Physics, Applied SC Physics GA 502KL UT WOS:000270458000060 ER PT J AU Earl, PL Cotter, C Moss, B VanCott, T Currier, J Eller, LA McCutchan, F Birx, DL Michael, NL Marovich, MA Robb, M Earla, PL AF Earl, Patricia L. Cotter, Catherine Moss, Bernard VanCott, Thomas Currier, Jeffrey Eller, Leigh Anne McCutchan, Francine Birx, Deborah L. Michael, Nelson L. Marovich, Mary A. Robb, Merlin Earla, Patricia L. TI Design and evaluation of multi-gene, multi-clade HIV-1 MVA vaccines SO VACCINE LA English DT Article DE MVA; HIV vaccine; Immune response ID HUMAN-IMMUNODEFICIENCY-VIRUS; IN-VITRO EXPRESSION; TYPE-1 SUBTYPE-C; T-CELL EPITOPES; ANKARA MVA; ENVELOPE GLYCOPROTEIN; IMMUNE-RESPONSES; RHESUS-MONKEYS; GAG-POL; PROTECTIVE IMMUNITY AB Recombinant modified vaccinia virus Ankara (rMVA) expressing HIV-1 genes are promising vaccine candidates. Toward the goal of conducting clinical trials with one or a cocktail of recombinant viruses, four rMVAs expressing env and gag-pol genes from primary HIV-1 isolates representing predominant subtypes from Kenya, Tanzania, Uganda, and Thailand (A, C, D, and CRF01_AE, respectively) were constructed. Efficient expression, processing, and function of Env and Gag were demonstrated. All inserted genes were shown to be genetically stable after repeated passage in cell culture. Strong HIV-specific cellular and humoral immune responses were elicited in mice immunized with each individual vaccine candidate. The MVA/CMDR vaccine candidate expressing CRF01_AE genes has elicited HIV-specific T-cell responses in two independent Phase I clinical trials. Further testing of the other rMVA is warranted. Published by Elsevier Ltd. C1 [Earl, Patricia L.; Cotter, Catherine; Moss, Bernard] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA. [Cotter, Catherine; VanCott, Thomas; Currier, Jeffrey; Eller, Leigh Anne; McCutchan, Francine; Birx, Deborah L.; Michael, Nelson L.; Marovich, Mary A.; Robb, Merlin; Earla, Patricia L.] Walter Reed Army Inst Res, Mil HIV Res Program, Rockville, MD USA. RP Earl, PL (reprint author), NIAID, Viral Dis Lab, NIH, 33 North Dr,MSC 3210, Bethesda, MD 20892 USA. EM pearl@niaid.nih.gov FU Intramural Research Program; National Institute of Allergy and Infectious Diseases; U.S. Army Medical Research and Materiel Command [DAMD17-98-27007] FX This work was supported in part by the Intramural Research Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health and by the U.S. Army Medical Research and Materiel Command and its Cooperative Agreement (DAMD17-98-27007) with the Henry M. Jackson Foundation for the Advancement of Military Medicine. The opinions or assertions contained herein are the private views of the author, and are not to be construed as official, or as reflecting true views of the Department of the Army or the Department of Defense. Research was conducted in compliance with the Animal Welfare Act and other federal statutes and regulations relating to animals and experiments involving animals and adheres to principles stated in the Guidefor the Care and Use of Laboratory Animals, NRC Publication, 1996 edition. NR 80 TC 34 Z9 36 U1 1 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD SEP 25 PY 2009 VL 27 IS 42 BP 5885 EP 5895 DI 10.1016/j.vaccine.2009.07.039 PG 11 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 502ON UT WOS:000270469900025 PM 19654066 ER PT J AU Kulkarni, H Marconi, VC He, WJ Landrum, ML Okulicz, JF Delmar, J Kazandjian, D Castiblanco, J Ahuja, SS Wright, EJ Weiss, RA Clark, RA Dolan, MJ Ahuja, SK AF Kulkarni, Hemant Marconi, Vincent C. He, Weijing Landrum, Michael L. Okulicz, Jason F. Delmar, Judith Kazandjian, Dickran Castiblanco, John Ahuja, Seema S. Wright, Edwina J. Weiss, Robin A. Clark, Robert A. Dolan, Matthew J. Ahuja, Sunil K. TI The Duffy-null state is associated with a survival advantage in leukopenic HIV-infected persons of African ancestry SO BLOOD LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; ACTIVE ANTIRETROVIRAL THERAPY; ETHNIC NEUTROPENIA; BLOOD-GROUP; AIDS SUSCEPTIBILITY; PLASMA-LEVELS; MALARIA; ANTIGEN; PATHOGENESIS; CHEMOKINES AB Persons of African ancestry, on average, have lower white blood cell (WBC) counts than those of European descent (ethnic leukopenia), but whether this impacts negatively on HIV-1 disease course remains unknown. Here, in a large natural history cohort of HIV-infected subjects, we show that, although leukopenia (< 4000 WBC/mm(3) during infection) was associated with an accelerated HIV disease course, this effect was more prominent in leukopenic subjects of European than African ancestry. The African-specific -46C/C genotype of Duffy Antigen Receptor for Chemokines (DARC) confers the malaria-resisting, Duffy-null phenotype, and we found that the recently described association of this genotype with ethnic leukopenia extends to HIV-infected African Americans (AAs). The association of Duffy-null status with HIV disease course differed according to WBC but not CD4(+) T-cell counts, such that leukopenic but not nonleukopenic HIV+ AAs with DARC -46C/C had a survival advantage compared with all Duffy-positive subjects. This survival advantage became increasingly pronounced in those with progressively lower WBC counts. These data highlight that the interaction between DARC genotype and the cellular milieu defined by WBC counts may influence HIV disease course, and this may provide a partial explanation of why ethnic leukopenia remains benign in HIV-infected AAs, despite immunodeficiency. (Blood. 2009;114:2783-2792) C1 [Kulkarni, Hemant; He, Weijing; Castiblanco, John; Ahuja, Seema S.; Clark, Robert A.; Ahuja, Sunil K.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA. [Kulkarni, Hemant; He, Weijing; Castiblanco, John; Ahuja, Seema S.; Clark, Robert A.; Ahuja, Sunil K.] S Texas Vet Hlth Care Syst, Vet Adm Res Ctr AIDS & HIV Infect 1, San Antonio, TX USA. [Marconi, Vincent C.; Landrum, Michael L.; Okulicz, Jason F.; Delmar, Judith] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Marconi, Vincent C.; Landrum, Michael L.; Okulicz, Jason F.; Delmar, Judith; Dolan, Matthew J.] Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Landrum, Michael L.; Dolan, Matthew J.] Henry M Jackson Fdn, Lackland AFB, TX USA. [Kazandjian, Dickran] Wilford Hall USAF Med Ctr, Dept Med, Lackland AFB, TX 78236 USA. [Wright, Edwina J.] Monash Univ, Fac Med Nursing & Hlth Sci, Melbourne, Vic 3004, Australia. [Wright, Edwina J.] Alfred Hosp, Burnet Inst, Melbourne, Vic, Australia. [Weiss, Robin A.] UCL, Div Infect & Immun, London, England. [Ahuja, Sunil K.] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol, San Antonio, TX 78229 USA. [Ahuja, Sunil K.] Univ Texas Hlth Sci Ctr San Antonio, Dept Immunol, San Antonio, TX 78229 USA. RP Ahuja, SK (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Med, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA. EM ahujas@uthscsa.edu RI CASTIBLANCO, JOHN/B-6599-2009; Marconi, Vincent/N-3210-2014; OI CASTIBLANCO, JOHN/0000-0002-7965-9822; Marconi, Vincent/0000-0001-8409-4689; CASTIBLANCO, JOHN/0000-0003-2556-3697 FU Veterans Administration Center on AIDS and HIV infection of the South Texas Veterans Health Care System; MERIT [R37046326]; National Institutes of Health [AI043279, MH069270]; Veterans Administration MERIT; Elizabeth Glaser Scientist Award; Burroughs Wellcome Clinical Scientist Award in Translational Research; Doris Duke Distinguished Clinical Scientist Award; Department of Defense HIV Natural History Study cohort; Infectious Disease Clinical Research Program of the Uniformed Services University of the Health Sciences; Uniformed Services University of the Health Sciences; Henry M. Jackson Foundation for the Advancement of Military Medicine; Human Services/National Institutes of Health/National Institute of Allergy and Infectious Diseases/Division of Clinical Research [Y1-AI-5072] FX The authors thank Duane Hospenthal, Brian Agan, and the anonymous reviewers for their critical feedback. This work was supported by the Veterans Administration Center on AIDS and HIV infection of the South Texas Veterans Health Care System, and a MERIT (R37046326) and other awards (AI043279 and MH069270) from the National Institutes of Health (S.K.A.). S. K. A. is also supported by a Veterans Administration MERIT award and is a recipient of the Elizabeth Glaser Scientist Award, the Burroughs Wellcome Clinical Scientist Award in Translational Research, and the Doris Duke Distinguished Clinical Scientist Award. Support for the Department of Defense HIV Natural History Study cohort and staff involved in this work was provided by the Infectious Disease Clinical Research Program of the Uniformed Services University of the Health Sciences, of which the HIV Natural History Study is a component. The Infectious Disease Clinical Research Program is a Department of Defense tri-service program executed through Uniformed Services University of the Health Sciences and the Henry M. Jackson Foundation for the Advancement of Military Medicine, in collaboration with Department of Health and Human Services/National Institutes of Health/National Institute of Allergy and Infectious Diseases/Division of Clinical Research through Interagency Agreement Y1-AI-5072.; The content of this publication is the sole responsibility of the authors and does not necessarily reflect the views or policies of the National Institutes of Health or the Department of Health and Human Services, the Department of Defense or the Departments of the Army, Navy or Air Force. Mention of trade names, commercial products, or organizations does not imply endorsement by the US Government. NR 49 TC 21 Z9 21 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 EI 1528-0020 J9 BLOOD JI Blood PD SEP 24 PY 2009 VL 114 IS 13 BP 2783 EP 2792 DI 10.1182/blood-2009-04-215186 PG 10 WC Hematology SC Hematology GA 498KK UT WOS:000270138600031 PM 19620399 ER PT J AU Snyder, JF Wetzel, ED Watson, CM AF Snyder, James F. Wetzel, Eric D. Watson, Cara M. TI Improving multifunctional behavior in structural electrolytes through copolymerization of structure- and conductivity-promoting monomers SO POLYMER LA English DT Article DE Electrolyte; Structural; Copolymer ID MOLECULAR-SIZE DISTRIBUTION; POLYMER ELECTROLYTES; IONIC-CONDUCTIVITY; MULTIPHASE COMPOSITES; POLY(ETHYLENE OXIDE); LITHIUM BATTERIES; DESIGN; LIQUID; EPOXY; NETWORKS AB Polymer electrolytes were developed to improve simultaneous demonstration of mechanical and electrochemical properties. Solvent-free random copolymers were synthesized using one monomer with poly(ethylene glycol) sidechains that promote lithium ion conduction and one crosslinking monomer that promotes high modulus. Sixty unique systems of monomer pairs were developed in this manner. The properties of the resulting copolymers were influenced by the monomer ratio and chemistry. The copolymers consistently exhibited improved electrochemical-mechanical multifunctionality with respect to the analogous homopolymers. The most promising systems included highly conductive components paired with highly structural components, suggesting that improved multifunctionality may be achieved through interpenetrating multicomponent systems in which each component demonstrates high efficiency in a single property. Electrochemical, mechanical, and viscoelastic properties are discussed with respect to composition and the glass transition temperature. Modeling of conductivity and modulus was employed to enable prediction of copolymer properties based on the ratio and properties of the constituents. Published by Elsevier Ltd. C1 [Snyder, James F.; Wetzel, Eric D.; Watson, Cara M.] USA, Res Lab, Div Mat, Aberdeen Proving Ground, MD 21005 USA. RP Snyder, JF (reprint author), USA, Res Lab, Div Mat, Aberdeen Proving Ground, MD 21005 USA. EM jsnyder@arl.army.mil FU Science and Engineering Apprenticeship Program administered through George Washington University FX The authors are grateful to Dr. John La Scala, Dr. Rob Carter, Dr. Rob Jensen, Dr. josh Orlicki, Dr. Joe Lenhart, and Dr. Kang Xu for helpful advice, and to Dr. La Scala for his assistance with the FT-IR experiments. Ms. Watson was supported by the Science and Engineering Apprenticeship Program administered through George Washington University. NR 40 TC 24 Z9 24 U1 4 U2 29 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 J9 POLYMER JI Polymer PD SEP 23 PY 2009 VL 50 IS 20 BP 4906 EP 4916 DI 10.1016/j.polymer.2009.07.050 PG 11 WC Polymer Science SC Polymer Science GA 535HY UT WOS:000272959300020 ER PT J AU Fain, X Ferrari, CP Dommergue, A Albert, MR Battle, M Severinghaus, J Arnaud, L Barnola, JM Cairns, W Barbante, C Boutron, C AF Fain, Xavier Ferrari, Christophe P. Dommergue, Aurelien Albert, Mary R. Battle, Mark Severinghaus, Jeff Arnaud, Laurent Barnola, Jean-Marc Cairns, Warren Barbante, Carlo Boutron, Claude TI Polar firn air reveals large-scale impact of anthropogenic mercury emissions during the 1970s SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE atmosphere; Greenland; past century; pollution ID ATMOSPHERIC MERCURY; GAS CONCENTRATIONS; CENTRAL GREENLAND; RECENT DECLINES; ATLANTIC-OCEAN; MACE HEAD; DEPOSITION; SNOW; ICE; DEPLETION AB Mercury (Hg) is an extremely toxic pollutant, and its biogeochemical cycle has been perturbed by anthropogenic emissions during recent centuries. In the atmosphere, gaseous elemental mercury (GEM; Hg degrees) is the predominant form of mercury (up to 95%). Here we report the evolution of atmospheric levels of GEM in mid- to high-northern latitudes inferred from the interstitial air of firn (perennial snowpack) at Summit, Greenland. GEM concentrations increased rapidly after World War II from approximate to 1.5 ng m(-3) reaching a maximum of approximate to 3 ng m(-3) around 1970 and decreased until stabilizing at approximate to 1.7 ng m(-3) around 1995. This reconstruction reproduces real-time measurements available from the Arctic since 1995 and exhibits the same general trend observed in Europe since 1990. Anthropogenic emissions caused a two-fold rise in boreal atmospheric GEM concentrations before the 1970s, which likely contributed to higher deposition of mercury in both industrialized and remotes areas. Once deposited, this toxin becomes available for methylation and, subsequently, the contamination of ecosystems. Implementation of air pollution regulations, however, enabled a large-scale decline in atmospheric mercury levels during the 1980s. The results shown here suggest that potential increases in emissions in the coming decades could have a similar large-scale impact on atmospheric Hg levels. C1 [Fain, Xavier; Ferrari, Christophe P.; Dommergue, Aurelien; Arnaud, Laurent; Barnola, Jean-Marc; Boutron, Claude] Univ Grenoble 1, CNRS, Lab Glaciol & Geophys Environm, UMR 5183, F-38402 St Martin Dheres, France. [Ferrari, Christophe P.; Dommergue, Aurelien] Univ Grenoble 1, Polytech Grenoble, F-38041 Grenoble, France. [Albert, Mary R.] Engineer Res & Dev Ctr, Geophys Sci Div, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Battle, Mark] Bowdoin Coll, Dept Phys & Astron, Brunswick, ME 04011 USA. [Severinghaus, Jeff] Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA. [Cairns, Warren; Barbante, Carlo] CNR, Inst Dynam Environm Proc, I-30123 Venice, Italy. [Barbante, Carlo] Univ Venice, Dept Environm Sci, I-30123 Venice, Italy. [Boutron, Claude] Univ Grenoble 1, Unite Format & Rech Phys, F-38041 Grenoble, France. RP Fain, X (reprint author), Desert Res Inst, Div Atmospher Sci, 2215 Raggio Pkwy, Reno, NV 89512 USA. EM xavier.fain@dri.edu RI Fain, Xavier/C-8645-2009; Dommergue, Aurelien/A-2829-2009; OI Fain, Xavier/0000-0002-4119-6025; Dommergue, Aurelien/0000-0002-8185-9604; Albert, Mary/0000-0001-7842-2359 FU U. S. National Science Foundation Office of Polar Programs [NSF-OPP 0520445]; French Atmospheric Chemistry Program "Exchanges Neige Polaire,"; French Ministry of Research [3012]; Laboratoire de Glaciologie et Geophysique de l'Environnement, and the Institut Universitaire de France FX We thank our Summit collaborators for their assistance during the field campaigns; the summer Summit crew, VECO Polar Resources, and the Air National Guard for providing logistical support during the field experiments; the Danish Polar Board and Greenlandic Home Rule Government for permission to work in Greenland, and the technical staff of Laboratoire de Glaciologie et Geophysique de l'Environnement for help in preparing our field campaigns. Weare grateful to P. Martinerie, J. McConnell, F. Parennin, and three anonymous reviewers for their helpful comments; T. Berg, F. Slemr, and A. Steffen for providing data; and R. Kreidberg for providing help in editing the manuscript. This research was funded by the U. S. National Science Foundation Office of Polar Programs project NSF-OPP 0520445, the French Atmospheric Chemistry Program "Exchanges Neige Polaire," the French Ministry of Research (Action Concertee Incitative Jeunes Chercheurs 3012), the Laboratoire de Glaciologie et Geophysique de l'Environnement, and the Institut Universitaire de France (to C. F. and C. B.). NR 62 TC 34 Z9 35 U1 2 U2 21 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD SEP 22 PY 2009 VL 106 IS 38 BP 16114 EP 16119 DI 10.1073/pnas.0905117106 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 497PF UT WOS:000270071600023 PM 19805267 ER PT J AU Bergmann-Leitner, ES Leitner, WW Duncan, EH Savranskaya, T Angov, E AF Bergmann-Leitner, Elke S. Leitner, Wolfgang W. Duncan, Elizabeth H. Savranskaya, Tatyana Angov, Evelina TI Molecular adjuvants for malaria DNA vaccines based on the modulation of host-cell apoptosis SO VACCINE LA English DT Article DE Malaria; DNA vaccine; Molecular adjuvant; Circumsporozoite protein; Protection ID CIRCUMSPOROZOITE PROTEIN; PLASMODIUM-BERGHEI; PROTECTIVE IMMUNITY; T-CELLS; EFFICACY; INFECTION; RESPONSES; ANTIGEN; SPOROZOITES; ENHANCEMENT AB Malaria represents a major global health problem but despite extensive efforts, no effective vaccine is available. Various vaccine candidates have been developed that provide protection in animal models, such as a gene gun-delivered DNA vaccine encoding the circumsporozoite protein (CSP) of Plasmodium berghei. A common shortcoming of most malaria vaccines is the requirement for multiple immunizations leaving room for improvement even for established vaccine candidates such as the CSP-DNA vaccine. In this study, we explored whether regulating apoptosis in DNA vaccine transfected host cells could accelerate the onset of protective immunity and provide significant protection after a single immunization. A proapoptotic gene (Bax) was used as a molecular adjuvant in an attempt to mimic the immunostimulatory apoptosis triggered by viral or virus-derived vaccines, while anti-apoptotic genes such as Bcl-XL may increase the life span of transfected cells thus prolonging antigen production. Surprisingly, co-delivery of either Bax or Bcl-XL greatly reduced CSP-DNA vaccine efficacy after a single immunization. Co-delivery of Bax for three immunizations still had a detrimental effect on protective immunity, while repeated co-delivery of Bcl-XL had no negative impact. The fine characterization of humoral and cellular immune response modulated by these two molecular adjuvants revealed a previously unknown effect, i.e., a shift in the Th-profile. These results demonstrate that pro- or anti-apoptotic molecules should not be used as molecular adjuvants without careful evaluation of the resulting immune response. This finding represents yet another example that strategies to enhance vaccine efficacy developed for other model systems such as viral diseases cannot easily be applied to any vaccine. (c) 2009 Elsevier Ltd. All rights reserved. C1 [Bergmann-Leitner, Elke S.; Duncan, Elizabeth H.; Angov, Evelina] Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Dept Mol Parasitol, Silver Spring, MD 20910 USA. [Leitner, Wolfgang W.] NCI, Dermatol Branch, NIH, Bethesda, MD 20892 USA. [Savranskaya, Tatyana] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA. RP Bergmann-Leitner, ES (reprint author), Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Dept Mol Parasitol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Elke.Bergmannleitner@us.army.mil RI Bergmann-Leitner, Elke/B-3548-2011; Leitner, Wolfgang/F-5741-2011 OI Bergmann-Leitner, Elke/0000-0002-8571-8956; Leitner, Wolfgang/0000-0003-3125-5922 FU United States Agency for International Development [936-6001, AAG-P-00-98-00006, AAG-P-0098-00005]; United States Army Medical Research and Materiel Command FX The authors would like to thank Dr. Richard joule for the proand anti-apoptotic plasmids. The work was initiated under the guidance of Dr. Jeffrey Lyon and supported by the United States Agency for International Development, Project Number 936-6001, Award Number AAG-P-00-98-00006, Award Number AAG-P-0098-00005 and by the United States Army Medical Research and Materiel Command. NR 38 TC 13 Z9 14 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD SEP 18 PY 2009 VL 27 IS 41 BP 5700 EP 5708 DI 10.1016/j.vaccine.2009.06.059 PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 497OW UT WOS:000270070400022 PM 19576940 ER PT J AU Fang, X Wallqvist, A Reifman, J AF Fang, Xin Wallqvist, Anders Reifman, Jaques TI A systems biology framework for modeling metabolic enzyme inhibition of Mycobacterium tuberculosis SO BMC SYSTEMS BIOLOGY LA English DT Article ID FLUX BALANCE ANALYSIS; ESCHERICHIA-COLI; DRUG TARGETS; SIDEROPHORE BIOSYNTHESIS; ISOCITRATE LYASE-1; PATHWAY ANALYSIS; GENOME; NETWORK; RECONSTRUCTION; GROWTH AB Background: Because metabolism is fundamental in sustaining microbial life, drugs that target pathogen-specific metabolic enzymes and pathways can be very effective. In particular, the metabolic challenges faced by intracellular pathogens, such as Mycobacterium tuberculosis, residing in the infected host provide novel opportunities for therapeutic intervention. Results: We developed a mathematical framework to simulate the effects on the growth of a pathogen when enzymes in its metabolic pathways are inhibited. Combining detailed models of enzyme kinetics, a complete metabolic network description as modeled by flux balance analysis, and a dynamic cell population growth model, we quantitatively modeled and predicted the dose-response of the 3-nitropropionate inhibitor on the growth of M. tuberculosis in a medium whose carbon source was restricted to fatty acids, and that of the 5'-O-(N-salicylsulfamoyl) adenosine inhibitor in a medium with low-iron concentration. Conclusion: The predicted results quantitatively reproduced the experimentally measured dose-response curves, ranging over three orders of magnitude in inhibitor concentration. Thus, by allowing for detailed specifications of the underlying enzymatic kinetics, metabolic reactions/constraints, and growth media, our model captured the essential chemical and biological factors that determine the effects of drug inhibition on in vitro growth of M. tuberculosis cells. C1 [Fang, Xin; Wallqvist, Anders; Reifman, Jaques] USA, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP Reifman, J (reprint author), USA, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. EM xfang@bioanalysis.org; awallqvist@bioanalysis.org; jaques.reifman@us.army.mil OI wallqvist, anders/0000-0002-9775-7469 FU U. S. Army Medical Research and Materiel Command, Ft. Detrick, Maryland; U. S. Army's Network Science Initiative FX The authors were supported, in part, by the Military Operational Medicine Research Area Directorate of the U. S. Army Medical Research and Materiel Command, Ft. Detrick, Maryland. This effort was supported by the U. S. Army's Network Science Initiative. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U. S. Army or of the U. S. Department of Defense. This paper has been approved for public release with unlimited distribution. NR 67 TC 25 Z9 26 U1 1 U2 9 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1752-0509 J9 BMC SYST BIOL JI BMC Syst. Biol. PD SEP 15 PY 2009 VL 3 AR 92 DI 10.1186/1752-0509-3-92 PG 22 WC Mathematical & Computational Biology SC Mathematical & Computational Biology GA 506ED UT WOS:000270755600001 PM 19754970 ER PT J AU Farley, JH Tian, CQ Rose, GS Brown, CL Birrer, M Maxwell, GL AF Farley, John H. Tian, Chunqiao Rose, G. Scott Brown, Carol L. Birrer, Michael Maxwell, G. Larry TI Race Does Not Impact Outcome for Advanced Ovarian Cancer Patients Treated With Cisplatin/Paclitaxel An Analysis of Gynecologic Oncology Group Trials SO CANCER LA English DT Article DE ovarian cancer; chemotherapy; Gynecologic Oncology Group; racial disparity ID INTRAVENOUS CISPLATIN PLUS; PHASE-III TRIAL; STAGE-III; UNITED-STATES; INTRAPERITONEAL CISPLATIN; SURGICAL CYTOREDUCTION; RACIAL DISPARITIES; PROGNOSTIC-FACTORS; AFRICAN-AMERICAN; PACLITAXEL AB BACKGROUND: The objectives of this study were to confirm whether racial disparity exists with regard to outcome between black women and white women with ovarian cancer and to identify factors associated with the administration of adjuvant treatment that had an impact on survival. METHODS: A retrospective review of 97 black women and 1392 white women with International Federation of Gynecology and Obstetrics stage III/IV ovarian carcinoma was performed. All patients received paclitaxel combined with cisplatin while participating in 1 of 7 Gynecologic Oncology Group clinical trials. The treatment parameters that were reviewed included relative dose, relative time, and relative dose intensity. The treatment parameters and outcomes were compared between black patients and white patients. RESULTS: There were no differences in relative dose (0.90 vs 0.89), relative time (1.02 vs 0.99), or relative dose intensity (0.90 vs 0.91) received between black patients and white patients. Black women had less grade 3 and 4 leukopenia (53% vs 63%; P < .05) and gastrointestinal toxicity (10% vs 19%; P < .05) than white women. Performance status >0, age >= 70 years, and mucinous histology were associated with not completing treatment (P < .001). The median progression-free survival was 16.2 months for black patients and 16.1 months for white patients, and the median overall survival was 37.9 months and 39.7 months, respectively (P > .05 for all). CONCLUSIONS: When they received similar treatment, there was no difference in clinical outcome between black women and white women with advanced stage epithelial ovarian cancer when they received similar treatment as participants in Gynecologic Oncology Group clinical trials. Black patients may experience less severe gastrointestinal toxicity or leukopenia compared with whites when treated with platinum-based chemotherapy. Cancer 2009;115:4210-7. Published 2009 by the American Cancer Society.* C1 [Farley, John H.] Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynaecol, Bethesda, MD 20832 USA. [Tian, Chunqiao] Roswell Pk Canc Inst, Gynecol Oncol Grp, Stat & Data Ctr, Buffalo, NY 14263 USA. [Rose, G. Scott; Maxwell, G. Larry] Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Washington, DC 20307 USA. [Rose, G. Scott; Maxwell, G. Larry] Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA. [Brown, Carol L.] Mem Sloan Kettering Canc Ctr, Dept Surg, Gynecol Serv, New York, NY 10021 USA. [Birrer, Michael] NCI, Ctr Canc Res, Bethesda, MD 20892 USA. RP Farley, JH (reprint author), Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynaecol, 4301 Jones Bridge Rd, Bethesda, MD 20832 USA. EM john.farley@us.army.mil FU American Board of Obstetrics and Gynecology/American Association of Obstetricians and Gynecologists Foundation; National Cancer Institute [CA 27469]; Gynecologic Oncology Group Statistical and Data Center [CA 37517] FX Supported by a grant from the American Board of Obstetrics and Gynecology/American Association of Obstetricians and Gynecologists Foundation and by National Cancer Institute grants to the Gynecologic Oncology Group Administrative Office (CA 27469) and the Gynecologic Oncology Group Statistical and Data Center (CA 37517). NR 25 TC 20 Z9 20 U1 0 U2 1 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0008-543X J9 CANCER JI Cancer PD SEP 15 PY 2009 VL 115 IS 18 BP 4210 EP 4217 DI 10.1002/cncr.24482 PG 8 WC Oncology SC Oncology GA 493BY UT WOS:000269709300023 PM 19536873 ER PT J AU Posel, Z Lisal, M Brennan, JK AF Posel, Zbysek Lisal, Martin Brennan, John K. TI Interplay between microscopic and macroscopic phase separations in ternary polymer melts: Insight from mesoscale modelling SO FLUID PHASE EQUILIBRIA LA English DT Article DE Diblock copolymers; Dissipative particle dynamics; Dynamic mean-field density functional theory; Homopolymers; Macrophase separation; Microphase separation; Phase diagram ID DISSIPATIVE PARTICLE DYNAMICS; BLOCK-COPOLYMERS; BICONTINUOUS MICROEMULSIONS; MICROPHASE SEPARATION; SIMULATION; BLENDS; DPD; EQUILIBRIA; SHEAR AB We present a mesoscale computational study of a ternary polymer melt comprising of two immiscible homopolymers A and B, and a symmetric diblock copolymer AB. The system exhibits rich phase behavior such as microphase separations in the copolymer-rich region and macrophase separations in the homopolymer-rich region. We use Dissipative Particle Dynamics (DPD) and Dynamic mean-field Density Functional Theory (DDFT) to predict the phase behavior along a temperature-homopolymer volume fraction isopleth for an A/B/AB mesoscale system that mimics a real system of low molecular weight poly(dimethyl siloxane) (PDMS) and poly(ethyl ethylene) (PEE) homopolymers, and a nearly symmetric PDMS-PEE diblock copolymer. The mesoscale polymer parameters are derived using a top-down coarse-graining approach that utilizes order-disorder and critical temperatures. Boundaries between disordered, lamellar and two-phase regions of the phase diagram are determined by visual inspection of configurational snapshots in combination with the abrupt changes that are exhibited by the diblock-copolymer orientational order parameter and bead order parameter when the phase boundaries are crossed. Phase diagrams predicted by DPD and DDFT agree reasonably well with the experimental phase diagram of the PDMS/PEE/PDMS-PEE system except for a narrow channel of bicontinuous microemulsion that is not predicted by either the DPD or the DDFT models. We discuss possible refinements of the models to capture this bicontinuous phase. (C) 2009 Elsevier B.V. All rights reserved. C1 [Lisal, Martin] Acad Sci Czech Republic, Inst Chem Proc Fundamentals, E Hala Lab Thermodynam, CR-16502 Prague 6, Suchdol, Czech Republic. [Posel, Zbysek; Lisal, Martin] Univ JE Purkyne, Inst Sci, Dept Phys, Usti Nad Labem 40096, Czech Republic. [Brennan, John K.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Lisal, M (reprint author), Acad Sci Czech Republic, Inst Chem Proc Fundamentals, E Hala Lab Thermodynam, Vvi Rozvojova 135, CR-16502 Prague 6, Suchdol, Czech Republic. EM lisal@icpf.cas.cz RI Lisal, Martin/A-8176-2011; Posel, Zbysek/B-2986-2013 OI Lisal, Martin/0000-0001-8005-7143; Posel, Zbysek/0000-0003-4271-5349 FU Czech Republic [203/08/0094]; National Research Programme "Information Society [IET400720507]; Czech Republic "Nanotechnology for Society" [KAN400720701]; European Community [TD0802] FX This research was supported by the Grant Agency of the Czech Republic (Grant No. 203/08/0094), by the National Research Programme "Information Society" (Project No. IET400720507), by the Grant Programme of Academy of Sciences of the Czech Republic "Nanotechnology for Society" (Project No. KAN400720701), and by the European Community under the 7th Framework Programme (Project COST TD0802). NR 46 TC 4 Z9 4 U1 1 U2 21 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3812 J9 FLUID PHASE EQUILIBR JI Fluid Phase Equilib. PD SEP 15 PY 2009 VL 283 IS 1-2 BP 38 EP 48 DI 10.1016/j.fluid.2009.05.014 PG 11 WC Thermodynamics; Chemistry, Physical; Engineering, Chemical SC Thermodynamics; Chemistry; Engineering GA 475UL UT WOS:000268386800006 ER PT J AU Miller, BF Campbell, TA Laseter, BR Ford, WM Miller, KV AF Miller, Brad F. Campbell, Tyler A. Laseter, Benjamin R. Ford, W. Mark Miller, Karl V. TI White-tailed deer herbivory and timber harvesting rates: Implications for regeneration success SO FOREST ECOLOGY AND MANAGEMENT LA English DT Article DE Allegheny hardwood-northern hardwood; Browse preferences; Herbivory; Odocoileus virginianus; Regeneration; Timber harvesting; West Virginia; White-tailed deer ID FRAGMENTED DECIDUOUS FORESTS; HARDWOOD REGENERATION; LOCALIZED MANAGEMENT; CENTRAL APPALACHIANS; DYNAMICS; POPULATIONS; INTERFERENCE; PENNSYLVANIA; INTENSITY; USA AB Herbivory by white-tailed deer (Odocoileus virginianus) can affect forest regeneration. Typical measures to ensure forest regeneration have included physical barriers or direct manipulation of deer densities. However, altering silvicultural practices to provide abundant deer forage has not been tested thoroughly. We examined browse species preferences and changes in herbivory rates in 1-6 year old regeneration areas from 2001 to 2004 in the central Appalachians on the MeadWestvaco Wildlife and Ecosystem Research Forest in West Virginia. Woody vegetation reached the maximum plot coverage by the 4th growing season. However, the establishment of less abundant woody species, such as northern red oak (Quercus rubra), may be inhibited when browsed greater than or proportionally to occurrence. Herbivory rates declined precipitously as the amount of early successional habitat increased on our study site. We conclude that providing approximately 14% of an area in well-distributed, even-aged managed forests can have substantial impacts on reducing herbivory rates. However, management practices also should consider harvesting effects on hard mast production, habitat requirements of other species, and hardwood lumber marketability. (C) 2009 Elsevier B.V. All rights reserved. C1 [Miller, Karl V.] Univ Georgia, Warnell Sch Forestry & Nat Resources, Athens, GA 30602 USA. [Miller, Brad F.] Arkansas Game & Fish Commiss, Little Rock, AR USA. [Campbell, Tyler A.] Texas A&M Univ, USDA, APHIS WS NWRC Texas Field Stn, Kingsville, TX USA. [Laseter, Benjamin R.] Fish & Wildlife Associates Inc, Whittier, NC USA. [Ford, W. Mark] USA, Engineer Res & Dev Ctr, Ecol Resources Branch, Environm Lab, Vicksburg, MS 39180 USA. [Miller, Karl V.] Univ Georgia, Warnell Sch Forestry & Nat Resources, Athens, GA 30602 USA. RP Miller, KV (reprint author), Univ Georgia, Warnell Sch Forestry & Nat Resources, Athens, GA 30602 USA. EM KMILLER@warnell.uga.edu FU West Virginia Department of Natural Resources; MeadWestvaco; USDA National Research Initiative Cooperative [00-35101-9284, 03-35101-13719] FX Financial assistance was provided by the West Virginia Department of Natural Resources, MeadWestvaco, and the USDA National Research Initiative Cooperative Grants program (grant 00-35101-9284 and 03-35101-13719). The comments of J.P. Carroll, C.J. Nairn, and R.J. Warren, improved early versions of this manuscript. We additionally thank the numerous volunteers, technicians, and others who contributed to this research. NR 47 TC 19 Z9 20 U1 2 U2 40 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-1127 J9 FOREST ECOL MANAG JI For. Ecol. Manage. PD SEP 15 PY 2009 VL 258 IS 7 BP 1067 EP 1072 DI 10.1016/j.foreco.2009.05.025 PG 6 WC Forestry SC Forestry GA 498OW UT WOS:000270152300005 ER PT J AU Doney, RL Agui, JH Sen, S AF Doney, Robert L. Agui, Juan H. Sen, Surajit TI Energy partitioning and impulse dispersion in the decorated, tapered, strongly nonlinear granular alignment: A system with many potential applications SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID SOLITON-LIKE PULSES; HERTZIAN CHAINS; QUARTZ BEADS; WAVES; PROPAGATION; IMPACT; BACKSCATTERING; CONTACT; COLUMNS; ALLOY AB Rapid absorption of impulses using light-weight, small, reusable systems is a challenging problem. An axially aligned set of progressively shrinking elastic spheres, a "tapered chain," has been shown to be a versatile and scalable shock absorber in earlier simulational, theoretical, and experimental works by several authors. We have recently shown (see R. L. Doney and S. Sen, Phys. Rev. Lett. 97, 155502 (2006)) that the shock absorption ability of a tapered chain can be dramatically enhanced by placing small interstitial grains between the regular grains in the tapered chain systems. Here we focus on a detailed study of the problem introduced in the above mentioned letter, present extensive dynamical simulations using parameters for a titanium-aluminum-vanadium alloy Ti(6)Al(4)V, derive attendant hard-sphere analyses based formulae to describe energy dispersion, and finally discuss some preliminary experimental results using systems with chrome spheres and small Nitinol interstitial grains to present the underlying nonlinear dynamics of this so-called decorated tapered granular alignment. We are specifically interested in small systems, comprised of several grains. This is because in real applications, mass and volume occupied must inevitably be minimized. Our conclusion is that the decorated tapered chain offers enhanced energy dispersion by locking in much of the input energy in the grains of the tapered chain rather than in the small interstitial grains. Thus, the present study offers insights into how the shock absorption capabilities of these systems can be pushed even further by improving energy absorption capabilities of the larger grains in the tapered chains. We envision that these scalable, decorated tapered chains may be used as shock absorbing components in body armor, armored vehicles, building applications and in perhaps even in applications in rehabilitation science. (C) 2009 American Institute of Physics. [doi:10.1063/1.3190485] C1 [Doney, Robert L.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Agui, Juan H.] NASA, Glenn Res Ctr, Cleveland, OH 44135 USA. [Sen, Surajit] SUNY Buffalo, Dept Phys, Buffalo, NY 14260 USA. RP Doney, RL (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM bdoney@arl.army.mil; juan.h.agui@nasa.gov; sen@dynamics.physics.buffalo.edu FU U. S. Army Research Office FX We are grateful to Professor M. Nakagawa, Professor S. Job, and Professor F. Melo for many valuable discussions on the TCs. R. L. D. thanks the U. S. Army Research Laboratory for their continuing financial support of this work. S. S. acknowledges support from the U. S. Army Research Office. NR 65 TC 12 Z9 12 U1 1 U2 7 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD SEP 15 PY 2009 VL 106 IS 6 AR 064905 DI 10.1063/1.3190485 PG 13 WC Physics, Applied SC Physics GA 501JP UT WOS:000270378100157 ER PT J AU Matsik, SG Jayaweera, PVV Perera, AGU Choi, KK Wijewarnasuriya, P AF Matsik, S. G. Jayaweera, P. V. V. Perera, A. G. U. Choi, K. K. Wijewarnasuriya, P. TI Device modeling for split-off band detectors SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID INFRARED PHOTODETECTORS; ROOM-TEMPERATURE; SCATTERING RATES AB An approach to develop room temperature detectors is to use transitions between the light/heavy hole bands and the split-off hole band to produce enhanced response at high temperature. Results are presented on a theoretical model to predict the response in these split-off detectors. The model calculates the dark and illuminated currents from the photoabsorption, carrier escape, and transport, explaining the experimental response. The variation in dark current, responsivity, and D* with the detector parameters is presented. (C) 2009 American Institute of Physics. [doi:10.1063/1.3224873] C1 [Matsik, S. G.; Jayaweera, P. V. V.; Perera, A. G. U.] Georgia State Univ, Dept Phys & Astron, Atlanta, GA 30303 USA. [Choi, K. K.; Wijewarnasuriya, P.] USA, Res Lab, Adelphi, MD 20783 USA. RP Matsik, SG (reprint author), Georgia State Univ, Dept Phys & Astron, Atlanta, GA 30303 USA. EM uperera@gsu.edu RI Jayaweera, Piyankarage Viraj/A-7387-2008; Choi, Kwong-Kit/K-9205-2013 FU U.S. Army [W911NF-08-1-0448] FX This work was supported by the U.S. Army under Grant No. W911NF-08-1-0448. NR 15 TC 7 Z9 7 U1 2 U2 5 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD SEP 15 PY 2009 VL 106 IS 6 AR 064503 DI 10.1063/1.3224873 PG 6 WC Physics, Applied SC Physics GA 501JP UT WOS:000270378100138 ER PT J AU Weingarten, NS Mattson, WD Rice, BM AF Weingarten, N. Scott Mattson, William D. Rice, Betsy M. TI Determination of the pressure dependent melting temperatures of Al and Ni using molecular dynamics SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID EMBEDDED-ATOM-METHOD; TRANSITION-METALS; THERMAL-EXPANSION; LIQUID INTERFACE; ALUMINUM; SILICON; NICKEL; SIMULATIONS; POTENTIALS; EQUATION AB We present the results of a molecular dynamics simulation study designed to calculate the melting temperatures of pure nickel and pure aluminum at various system pressures using an embedded atom method type potential. The melting points are determined using a two-phase coexistence method, where the liquid and solid phases are modeled simultaneously at a fixed pressure and temperature, allowing us to bracket the value within a desired range of accuracy. The values obtained for the melting points of aluminum are consistently higher than expected based on experiment, while those for nickel are lower. Other thermal properties of aluminum and nickel were determined in order to fit the melting temperature data into a standard theoretical framework. Also, planar material defects, such as twin boundaries and stacking faults, were observed in crystals grown from the melt, occurring more often in aluminum systems than in nickel. Planar defect energies were calculated for both systems in order to explain these observations. (C) 2009 American Institute of Physics. [doi: 10.1063/1.3213342] C1 [Weingarten, N. Scott; Mattson, William D.; Rice, Betsy M.] USA, Res Lab, Weap & Mat Res Directorate RDRL WMB D, Aberdeen Proving Ground, MD 21005 USA. RP Weingarten, NS (reprint author), USA, Res Lab, Weap & Mat Res Directorate RDRL WMB D, Aberdeen Proving Ground, MD 21005 USA. EM scott.weingarten@arl.army.mil NR 48 TC 28 Z9 28 U1 3 U2 12 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD SEP 15 PY 2009 VL 106 IS 6 AR 063524 DI 10.1063/1.3213342 PG 7 WC Physics, Applied SC Physics GA 501JP UT WOS:000270378100058 ER PT J AU Bednar, AJ Kirgan, RA Karn, RA Donovan, B Mohn, MF Sirkis, DM AF Bednar, A. J. Kirgan, R. A. Karn, R. A. Donovan, B. Mohn, M. F. Sirkis, D. M. TI Mobility and sorption of bis-2-chloroethyl ether in an aquifer material SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE BCEE; Bis-2-chloroethyl ether; Sorption; Aquifer material; Column leach ID ORGANIC-COMPOUNDS; POROUS-MEDIA; SOIL; DNAPL; SOLUBILIZATION; REMEDIATION AB Active treatment of BCEE (bis-2-chloroethyl ether) is being currently performed in the on-site Cohansey Aquifer at the Lipari Superfund Site. Remediation of BCEE in the underlying Kirkwood aquifer is being considered, necessitating investigations of BCEE geochemistry in aquifer material from the site. It is currently unknown to what extent BCEE is present in the dissolved. sorbed, or free-product phase in the Kirkwood Sand aquifer material. A series of partition coefficient sorption, column leach, and column loading tests were conducted to determine BCEE sorption to, and mobility in, the Kirkwood Sand aquifer material. The leach studies indicated that up to 50% of BCEE spiked (as free-phase product) onto two aquifer material column designs could be leached in approximately 18 h, due to the high aqueous solubility of BCEE. Dissolved BCEE concentrations then began to plateau as sorption reactions hindered further leaching, resulting in up to 80% removal after 48 h. Column loading and batch sorption experiments suggest that BCEE mobility is limited by sorption rather than solubility factors. Tracer tests in both column loading and batch sorption tests indicate sorption hinders leaching of BCEE from the Kirkwood Sand material. Published by Elsevier B.V. C1 [Bednar, A. J.; Kirgan, R. A.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Donovan, B.] US EPA, Washington, DC USA. [Mohn, M. F.; Sirkis, D. M.] US Army Engineer Philadelphia Dist, Philadelphia, PA USA. RP Bednar, AJ (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Anthony.J.Bednar@usace.army.mil FU Chief of Engineers FX The use of trade, product, or firm names in this report is for descriptive purposes only and does not imply endorsement by the U.S. Government. Permission was granted by the Chief of Engineers to publish this information. The findings of this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. The authors thank Deborah Felt and Christian McGrath of the USACE for their editorial comments. NR 24 TC 0 Z9 0 U1 1 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD SEP 15 PY 2009 VL 168 IS 2-3 BP 1041 EP 1046 DI 10.1016/j.jhazmat.2009.02.138 PG 6 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 473IX UT WOS:000268200700069 PM 19345490 ER PT J AU Thellen, C Schirmer, S Ratto, JA Finnigan, B Schmidt, D AF Thellen, Christopher Schirmer, Sarah Ratto, Jo Ann Finnigan, Bradley Schmidt, Daniel TI Co-extrusion of multilayer poly(m-xylylene adipimide) nanocomposite films for high oxygen barrier packaging applications SO JOURNAL OF MEMBRANE SCIENCE LA English DT Article DE Barrier; Films; Nanocomposite; Nylon; Packaging ID MECHANICAL-PROPERTIES; FRACTURE-TOUGHNESS; POLYMER; HYBRID AB Multilayer packaging films incorporating a montmorillonite layered silicate (MLS)/poly(m-xylylene adipimide) (MXD6) nanocomposite as the oxygen barrier layer and low-density polyethylene (LDPE) as the moisture resistant layer were produced through the co-extrusion process at the laboratory and pilot scale level. Extrusion screw speeds were varied from 30 to 130 rpm in order to produce samples with varying layer thicknesses. The multilayer film structure was scaled up from the laboratory scale to the pilot-level scale based on oxygen transmission data obtained from the laboratory-scale process parameters. Laboratory-scale film results indicated that the film which demonstrated an optimal oxygen transmission rate (OTR) of 0.3 cm(3)/(m(2) day) at 60% RH and water vapor transmission rate (WvTR) of 1.4 g/(m(2) day) at 90%RH had a structure that contained a core barrier film layer of nanocomposite MXD6 that makes up roughly 34% of the total film thickness, with the remainder of the film material consisting of maleic anhydride grafted polyolefin tie layers and LDPE skin layers. The OTR of the films changed as the relative humidity of the test environment was varied from 0 to 90%. However, for the pilot-scale trial it was necessary to reduce the target thickness of the core nylon barrier layer to 22% due to layer-to-layer melt flow instabilities that occurred during processing. The barrier properties of the multi-layer co-extruded films were highly dependant on overall film thickness. The highest performing oxygen barrier pilot-scale film had an OTR of 0.3 cm(3)/(m(2) day) (60%RH) and a WvTR of 2.4 g/(m(2) day) (90%RH) with a core nylon layer of 1.5 mil and a total thickness of 7.7 mil. Correlation of the layer thicknesses to the barrier and mechanical properties of the pilot-scale multilayer films indicated that an increased nanocomposite core layer thickness improved the oxygen barrier performance and decreased film elongation while improving the tear resistance of the films. Published by Elsevier B.V. C1 [Thellen, Christopher; Schirmer, Sarah; Ratto, Jo Ann; Finnigan, Bradley; Schmidt, Daniel] USA, Natick Soldier Res, Ctr Dev & Engn, Adv Mat Engn Team, Natick, MA 01760 USA. RP Thellen, C (reprint author), USA, Natick Soldier Res, Ctr Dev & Engn, Adv Mat Engn Team, Kansas St, Natick, MA 01760 USA. EM Christopher.Thellen@us.army.mil FU Strategic Environmental Research and Development Program (SERDP); Nanocomposites for Optimized Packaging Structures (NANOPS) FX The authors would like to thank the Strategic Environmental Research and Development Program (SERDP) "Reduction of Solid Waste Associated with Military Rations and Packaging" and the U.S. Army Solid Waste Reduction Program, in particular, the Nanocomposites for Optimized Packaging Structures (NANOPS) program for supporting this research. Support was also received from the U.S. Army Natick Soldier Research, Development and Engineering Center, in particular, Ms. Jeanne Lucciarini and Mr. Gerald Darsch of the Combat Feeding Directorate. The authors would also like to acknowledge Dr. Tie Lan of Nanocor for supplying the nanocomposite resin and offering his technical support during this project, as well as Dr. Doug Lilac formerly of Pliant Corporation and Mr. Renny Kuhlman of Pliant Corporation. A special thank you also goes out to Professor Stephen McCarthy of the University of Massachusetts Lowell for his guidance and support. Without all of these groups and individuals, this research would not have been possible. NR 33 TC 22 Z9 23 U1 1 U2 30 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0376-7388 J9 J MEMBRANE SCI JI J. Membr. Sci. PD SEP 15 PY 2009 VL 340 IS 1-2 BP 45 EP 51 DI 10.1016/j.memsci.2009.05.011 PG 7 WC Engineering, Chemical; Polymer Science SC Engineering; Polymer Science GA 475GP UT WOS:000268346900006 ER PT J AU Leal, AA Deitzel, JM McKnight, SH Gillespie, JW AF Leal, A. Andres Deitzel, Joseph M. McKnight, Steven H. Gillespie, John W., Jr. TI Spectroscopic Analysis and Kinetics of Intermolecular Hydrogen Bond Formation in Poly-pyridobisimidazole (M5) Fiber SO JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS LA English DT Article DE annealing; fibers; hydrogen bonding; infrared spectroscopy; poly-pyridobisimidazole ID RIGID-ROD POLYMER; INFRARED-SPECTROSCOPY; MECHANICAL-PROPERTIES; COMPRESSIVE STRENGTH; HIGH-MODULUS; KEVLAR 49; PIPD; TEMPERATURE; IMIDAZOLE; CELLULOSE AB Poly-pyridobisimiazole (M5) single filaments subjected to varying degrees of heat treatment have been analyzed using Fourier Transform Infrared (FTIR) microspectroscopy in transmission mode to detect changes in the state of intermolecular hydrogen bonding as a function of fiber annealing conditions. The FTIR absorbance bands associated with hydrogen bonding in M5 fiber have been identified, and the integrated molar absorption coefficients for the bands of interest have been determined experimentally, which allows to quantify the concentration of N-H vibration groups hydrogen-bonded (H-bonded) to water molecules, and the concentration of N-H vibration groups H-bonded to adjacent polymer chains in the fiber. A dual mechanism kinetic rate expression is used to describe intermolecular H-bond formation in M5 fiber as a function of annealing conditions, from which an activation energy for H-bond formation of 14.8 kJ/mol is obtained. (C) 2009 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 47: 1809-1824, 2009 C1 [Leal, A. Andres; Deitzel, Joseph M.; Gillespie, John W., Jr.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. [Leal, A. Andres; Gillespie, John W., Jr.] Univ Delaware, Dept Mat Sci & Engn, Newark, DE 19716 USA. [McKnight, Steven H.] Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. [Gillespie, John W., Jr.] USA, Res Lab, Div Mat, Aberdeen, MD 21005 USA. RP Gillespie, JW (reprint author), Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. EM gillespi@udel.edu FU U.S. Army Research Laboratory [DAAD19-01-2-0005] FX The authors acknowledge the financial support provided by the Composite Materials Technology (CMT) Collaborative Program sponsored by the U.S. Army Research Laboratory under Cooperative Agreement DAAD19-01-2-0005. The authors like to thank Philip Cunniff for providing the M5 (R) as-spun fiber samples. Additionally, the authors like to thank Frederick Beyer at the Army Research Laboratory for his help in obtaining WARD measurements for the M5 fiber. NR 45 TC 5 Z9 5 U1 1 U2 29 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0887-6266 J9 J POLYM SCI POL PHYS JI J. Polym. Sci. Pt. B-Polym. Phys. PD SEP 15 PY 2009 VL 47 IS 18 BP 1809 EP 1824 DI 10.1002/polb.21767 PG 16 WC Polymer Science SC Polymer Science GA 492CP UT WOS:000269632200008 ER PT J AU Nissan, A Stojadinovic, A Garofalo, A Esquivel, J Piso, P AF Nissan, Aviram Stojadinovic, Alexander Garofalo, Alfredo Esquivel, Jesus Piso, Pompiliu TI Evidence-Based Medicine in the Treatment of Peritoneal Carcinomatosis: Past, Present, and Future SO JOURNAL OF SURGICAL ONCOLOGY LA English DT Review DE peritoneal surface malignancies; carcinomatosis; hyperthermic chemotherapy; clinical trial; cytoreduction ID METASTATIC COLORECTAL-CANCER; HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY; GYNECOLOGIC-ONCOLOGY-GROUP; STAGE-III OVARIAN; FLUOROURACIL PLUS LEUCOVORIN; MULTICENTER RANDOMIZED-TRIAL; CYTOREDUCTIVE SURGERY; GASTRIC-CANCER; CURATIVE RESECTION; MILKY SPOTS AB The current treatment of peritoneal surface malignancies (PSMs) is moving from a nihilistic approach, into a combined modality approach offering selected patients long-term survival. As primary PSM are rare, extrapolation of data from clinical trials of related disease is necessary to develop treatment guidelines. Secondary PSM are more common, and therefore, treatment guidelines should be developed based on prospective clinical trials. We reviewed the published and ongoing clinical trials studying the treatment of PSM. J. Surg. Oncol. 2009:100:335-344. Published 2009 Wiley-Liss, Inc.(dagger) C1 [Nissan, Aviram] Hadassah Hebrew Univ Med Ctr Mt Scopus, Dept Surg, IL-91240 Jerusalem, Israel. [Nissan, Aviram; Stojadinovic, Alexander; Esquivel, Jesus] US Mil Canc Inst, Washington, DC USA. [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Div Surg Oncol, Washington, DC 20307 USA. [Garofalo, Alfredo] Natl Canc Inst Regina Elena, Digest Branch, Dept Surg Oncol, Rome, Italy. [Esquivel, Jesus] St Agnes Hosp, Dept Surg, Peritoneal Surface Malignancy Program, Baltimore, MD USA. [Piso, Pompiliu] Univ Regensburg, Chirurg Klin & Poliklin, Regensburg, Germany. RP Nissan, A (reprint author), Hadassah Hebrew Univ Med Ctr Mt Scopus, Dept Surg, POB 24035, IL-91240 Jerusalem, Israel. EM anissan@hadassah.org.il NR 100 TC 16 Z9 18 U1 1 U2 3 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0022-4790 J9 J SURG ONCOL JI J. Surg. Oncol. PD SEP 15 PY 2009 VL 100 IS 4 BP 335 EP 344 DI 10.1002/jso.21323 PG 10 WC Oncology; Surgery SC Oncology; Surgery GA 492BZ UT WOS:000269630400012 PM 19697442 ER PT J AU Theeler, BJ Keylock, J Yoest, S Forouhar, M AF Theeler, Brett J. Keylock, Joren Yoest, Stephen Forouhar, Melissa TI Ewing's sarcoma family tumors mimicking primary central nervous system neoplasms SO JOURNAL OF THE NEUROLOGICAL SCIENCES LA English DT Article DE Primitive neuroectodermal tumor; Ewing's Sarcoma; Embryonal tumors of the central nervous system ID PRIMITIVE NEUROECTODERMAL TUMORS; PERIPHERAL PNET/EWINGS SARCOMA; BRAIN; SPINE; PNET; MANAGEMENT; CHILDHOOD; ENTITY; DURA AB Ewing's sarcoma family tumors (ESFTs) and embyronal tumors of the central nervous system are malignant primitive neuroectodermal tumors (PNETs) that can arise in the central nervous system, bones, or soft tissues. When ESFTs involve the central nervous system or nearby structures the diagnosis depends on cytogenetics and immunohistochemistry as these tumors can appear otherwise histologically identical to central PNETs. Correct diagnosis is essential as the treatment paradigms for both entities differ. We present two cases of isolated central nervous system presentations of ESFTs mimicking primary central nervous system neoplasms. Published by Elsevier B.V. C1 [Theeler, Brett J.] USA, Dept Med, Neurol Serv, Washington, DC 20310 USA. [Keylock, Joren] USA, Dept Pathol, Washington, DC 20310 USA. [Yoest, Stephen] USA, Dept Radiol, Washington, DC 20310 USA. [Forouhar, Melissa] USA, Dept Pediat, Washington, DC 20310 USA. RP Theeler, BJ (reprint author), Madigan Army Med Ctr, Ft Lewis, WA 98433 USA. EM btheeler@hotmail.com NR 26 TC 9 Z9 11 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-510X J9 J NEUROL SCI JI J. Neurol. Sci. PD SEP 15 PY 2009 VL 284 IS 1-2 BP 186 EP 189 DI 10.1016/j.jns.2009.03.031 PG 4 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 514YW UT WOS:000271433900038 PM 19394051 ER PT J AU Linkov, I Loney, D Cormier, S Satterstrom, FK Bridges, T AF Linkov, Igor Loney, Drew Cormier, Susan Satterstrom, F. Kyle Bridges, Todd TI Weight-of-evidence evaluation in environmental assessment: Review of qualitative and quantitative approaches SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Review DE Weight of evidence; Environmental risk assessment; Ecological risk assessment; Human health risk assessment; multi-criteria decision analysis ID ECOLOGICAL RISK-ASSESSMENT; MULTICRITERIA DECISION-ANALYSIS; CONTAMINATED SITES; SEDIMENT QUALITY; BIOAVAILABILITY; SELECTION; EXPOSURE; CRITERIA; SYSTEM; SOIL AB Assessments of human health and ecological risk draw upon multiple types and sources of information, requiring the integration of multiple lines of evidence before conclusions may be reached. Risk assessors often make use of weight-of-evidence (WOE) approaches to perform the integration, whether integrating evidence concerning potential carcinogenicity, toxicity, and exposure from chemicals at a contaminated site, or evaluating processes concerned with habitat loss or modification when managing a natural resource. Historically. assessors have relied upon qualitative WOE approaches, such as professional judgment, or limited quantitative methods, such as direct scoring, to develop conclusions from multiple lines of evidence. Current practice often lacks transparency resulting in risk estimates lacking quantified uncertainty. This paper reviews recent applications of weight of evidence used in human health and ecological risk assessment. Applications are sorted based on whether the approach relies on qualitative and quantitative methods in order to reveal trends in the use of the term weight of evidence, especially as a means to facilitate structured and transparent development of risk conclusions from multiple lines of evidence. Published by Elsevier B.V. C1 [Linkov, Igor; Loney, Drew; Bridges, Todd] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Loney, Drew] MIT, Cambridge, MA 02139 USA. [Cormier, Susan] US EPA, Natl Ctr Environm Assessment, Cincinnati, OH 45268 USA. [Satterstrom, F. Kyle] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA. RP Linkov, I (reprint author), USA, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Igor.Linkov@usace.army.mil FU US Army Corps of Engineers; Dredging Operations and Environmental Research (DOER) FX We would like to thank Drs. Jongbum Kim, Joshua Gold, Burton Suedel, and Tom Seager for their comments and useful discussions. Funding was provided by the US Army Corps of Engineers' Dredging Operations and Environmental Research (DOER) Program. Permission was granted by the USACE Chief of Engineers to publish this material. NR 58 TC 87 Z9 93 U1 8 U2 66 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD SEP 15 PY 2009 VL 407 IS 19 BP 5199 EP 5205 DI 10.1016/j.scitotenv.2009.05.004 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA 491JY UT WOS:000269576100001 PM 19619890 ER PT J AU Che, MM Conti, M Chanda, S Boylan, M Sabnekar, P Rezk, P Amari, E Sciuto, AM Gordon, RK Doctor, BP Nambiar, MP AF Che, Magnus M. Conti, Michele Chanda, Soma Boylan, Megan Sabnekar, Praveena Rezk, Peter Amari, Ethery Sciuto, Alfred M. Gordon, Richard K. Doctor, Bhupendra P. Nambiar, Madhusoodana P. TI Post-exposure treatment with nasal atropine methyl bromide protects against microinstillation inhalation exposure to sarin in guinea pigs SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article DE Organophosphates; Seizure/status epilepticus; Respiratory toxicity; Cholinesterases; Neuroprotection; Inhalation exposure; Nerve agents; Guinea pigs ID TOKYO SUBWAY; ACETYLCHOLINESTERASE ACTIVITY; DISASTER MANAGEMENT; NERVE AGENTS; RATS; VAPOR; TOXICITY; ATTACK; SOMAN; SINGLE AB We evaluated the protective efficacy of nasal atropine methyl bromide (AMB) which does not cross the blood-brain barrier against satin inhalation exposure. Age and weight matched male guinea pigs were exposed to 846.5 mg/m(3) satin using a microinstillation inhalation exposure technique for 4 min. The survival rate at this dose was 20%. Post-exposure treatment with nasal AMB (2.5 mg/kg, 1 min) completely protected against satin induced toxicity (100% survival). Development of muscular tremors was decreased in animals treated with nasal AMB. Post-exposure treatment with nasal AMB also normalized acute decrease in blood oxygen saturation and heart rate following satin exposure. Inhibition of blood AChE and BChE activities following satin exposure was reduced in animals treated with nasal AMB, indicating that survival increases the metabolism of satin or expression of AChE. The body weight loss of animals exposed to satin and treated with nasal AMB was similar to saline controls. No differences were observed in lung accessory lobe or tracheal edema following exposure to satin and subsequent treatment with nasal AMB. Total bronchoalveolar lavage fluid (BALF) protein, a biomarker of lung injury, showed trends similar to saline controls. Surfactant levels post-exposure treatment with nasal AMB returned to normal, similar to saline controls. Alkaline phosphatase levels post-exposure treatment with nasal AMB were decreased. Taken together, these data suggest that nasal AMB blocks the copious airway secretion and peripheral cholinergic effects and protects against lethal inhalation exposure to sarin thus increasing survival. (C) 2009 Published by Elsevier Inc. C1 [Che, Magnus M.; Chanda, Soma; Amari, Ethery; Doctor, Bhupendra P.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Div Biochem, Dept Biochem Pharmacol, Silver Spring, MD 20910 USA. [Conti, Michele; Boylan, Megan; Sabnekar, Praveena; Rezk, Peter; Sciuto, Alfred M.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Gordon, Richard K.] Walter Reed Army Inst Res, Div Regulated Activ, Dept Regulated Lab, Silver Spring, MD 20910 USA. [Nambiar, Madhusoodana P.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. RP Nambiar, MP (reprint author), Walter Reed Army Inst Res, Dept Closed Head Injury, Brain Dysfunct & Blast Injury Div, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Madhusoodana.nambiar@amedd.army.mil FU National Institutes of Environmental Health Sciences/National Institutes of Health [5U01ES015677] FX The project described was supported by Grant Number 5U01ES015677 from the National Institutes of Environmental Health Sciences/National Institutes of Health and managed by the Geneva Foundation, Lakewood, WA. Its contents, opinions and assertions contained herein are private views of the authors are not to be construed as official or reflecting the views of the National Institutes of Environmental Health Sciences/National Institutes of Health, Department of the Army or the Department of Defense. NR 46 TC 8 Z9 8 U1 0 U2 4 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD SEP 15 PY 2009 VL 239 IS 3 BP 251 EP 257 DI 10.1016/j.taap.2009.06.002 PG 7 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 492RN UT WOS:000269677000005 PM 19523969 ER PT J AU Parker, JK Espada-Jallad, C AF Parker, James K. Espada-Jallad, Cyntia TI Kinetics of the Gas-Phase Reactions of OH and NO3 Radicals and O-3 with Allyl Alcohol and Allyl Isocyanate SO JOURNAL OF PHYSICAL CHEMISTRY A LA English DT Article ID MOLECULAR-ORBITAL METHODS; GAUSSIAN-BASIS SETS; UNSATURATED ALCOHOLS; ORGANIC-COMPOUNDS; RATE COEFFICIENTS; RATE CONSTANTS; 3RD-ROW ATOMS; PERTURBATION-THEORY; WAVE-FUNCTIONS; MECHANISMS AB Rate constants for the gas-phase reactions of OH radical, NO3 radical, and ozone with allyl alcohol (AAL) and allyl isocyanate (AIC) have been measured using relative rate methods at atmospheric pressure in purified air. The experimental Arrhenius expression obtained for the reaction of the OH radical with AAL is (1.68 +/- 0.89) x 10(-12) x exp(1100/T) cm(3) molecule(-1) s(-1), for T = 282-315 K; the Arrhenius expression for the reaction of OH radical with AIC is (1.94 +/- 1.04) x 10(-14) x exp(2207/T) cm(3) molecule(-1) s(-1), for T = 282-317 K, where the indicated errors are one least-squares standard deviation. All OH radical reaction rate constants have been measured relative to k(OH + alpha-pinene) and k(OH + 1,3,5-trimethylbenzene). The rate constant for the gas-phase reaction of OH radical with allyl alcohol-d(6) isotopomer (AAL-d(6)) has been measured at T = 298 K, and the value is 5.10 x 10(-11) cm(3) molecule(-1) s(-1). The kinetic isotope effect is small, with k(AAL)/k-(AAL-d(6)) = 1.32. Rate constants for the gas-phase reactions of NO3 radical with AAL [relative to k(NO3 + methacrolein)] and O-3 [relative to k(O-3 + beta-pinene)] have been measured, and the values are 7.7 x 10(-15) cm(3) molecule(-1) s(-1) at T = 298 K and 1.6 x 10(-17) cm(3) molecule(-1) s(-1) at T = 296 K, respectively. Rate constants for the gas-phase reactions of NO3 radical and O-3 with AIC have been measured, and the values are 9.4 x 10(-16) cm(3) molecule(-1) s(-1) at T = 299 K and 5.54 x 10(-18) cm(3) molecule(-1) s(-1) at T = 299 K, respectively. Multireference ab initio calculations at the MRMP2/6-311G(d,p) level have been carried out for reactions of OH radical with AAL and AIC. Results indicate that prereactive hydrogen bonded complexes form in the entrance channels for these reactions. C1 [Parker, James K.; Espada-Jallad, Cyntia] Midwest Res Inst, Kansas City, MO 64110 USA. RP Parker, JK (reprint author), USA, Res Off, 4300 S Miami Blvd, Durham, NC 27703 USA. EM james.kenneth.parker@arl.army.mil FU Midwest Research Institute FX Financial support of this work was provided by an Internal Research and Development grant from Midwest Research Institute. The authors are grateful for this support. We thank Mr. Pete Deardorff and Dr. Bruce Diel for providing samples of methyl nitrite and dinitrogen pentoxide. NR 44 TC 11 Z9 11 U1 3 U2 20 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1089-5639 J9 J PHYS CHEM A JI J. Phys. Chem. A PD SEP 10 PY 2009 VL 113 IS 36 BP 9814 EP 9824 DI 10.1021/jp9055939 PG 11 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 492KT UT WOS:000269655400007 PM 19725585 ER PT J AU Yeh, IC Wallqvist, A AF Yeh, In-Chul Wallqvist, Anders TI Structure and Dynamics of End-to-End Loop Formation of the Penta-Peptide Cys-Ala-Gly-Gln-Trp in Implicit Solvents SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID GENERALIZED BORN MODEL; EXCHANGE MOLECULAR-DYNAMICS; INTRAMOLECULAR CONTACT FORMATION; PARTICLE MESH EWALD; ATOM FORCE-FIELD; FREE-ENERGY; REPLICA-EXCHANGE; PROTEIN STRUCTURES; BETA-HAIRPIN; SIMULATIONS AB To investigate the effects of implicit solvents on peptide structure and dynamics, we performed extensive molecular dynamics simulations on the penta-peptide Cys-Ala-Gly-Gln-Trp. Two different implicit solvent models based on the CHARMM22 all-atom force field were used. Structural properties of the peptide such as distributions of end-to-end distances and dihedral angles obtained from molecular dynamics simulations with implicit solvent models were in a good agreement with those obtained from a previous explicit solvent simulation using the same force field. Representative structures observed in explicit solvent were sampled by implicit solvent models but with different relative probabilities. However, we observed significant differences in dynamical properties in explicit and implicit solvent models when we used traditional methods for the temperature control, such as Nose-Hoover or Berendsen thermostats. The explicitly solvated peptide displayed the slowest dynamics in both end-to-end contact formation and intrinsic diffusive motion of end-to-end distances. A closer agreement between implicit and explicit solvated peptide dynamics was observed when Langevin dynamics with a friction coefficient of 10 ps(-1) was used to maintain the temperature of the systems. C1 [Yeh, In-Chul] USA, Med Res & Mat Command, Biotechnol HPC Software Applicat Inst, ATTN MCMR TT,Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. RP Yeh, IC (reprint author), USA, Med Res & Mat Command, Biotechnol HPC Software Applicat Inst, ATTN MCMR TT,Telemed & Adv Technol Res Ctr, Bldg 363 Miller Dr, Ft Detrick, MD 21702 USA. EM icy@bioanalysis.org OI wallqvist, anders/0000-0002-9775-7469 FU HPC Software Applications Institute; U.S. Army Medical Research and Materiel Command FX We thank Dr. Michael S. Lee and Dr. Mark A. Olson for helpful suggestions and discussions. Funding support for this work came from the Department of Defense (DoD) High Performance Computing (HPC) Modernization Program Office under the HPC Software Applications Institute initiative, the U.S. Army Medical Research and Materiel Command. Computational time was provided by the U.S. Army Research Laboratory DoD Supercomputing Resource Center. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or of the U.S. Department of Defense. NR 60 TC 15 Z9 15 U1 0 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD SEP 10 PY 2009 VL 113 IS 36 BP 12382 EP 12390 DI 10.1021/jp904064z PG 9 WC Chemistry, Physical SC Chemistry GA 492KS UT WOS:000269655300029 PM 19685925 ER PT J AU Cheatham, RA Roberts, SB Das, SK Gilhooly, CH Golden, JK Hyatt, R Lerner, D Saltzman, E Lieberman, HR AF Cheatham, Rachel A. Roberts, Susan B. Das, Sai Krupa Gilhooly, Cheryl H. Golden, Julie K. Hyatt, Raymond Lerner, Debra Saltzman, Edward Lieberman, Harris R. TI Long-term effects of provided low and high glycemic load low energy diets on mood and cognition SO PHYSIOLOGY & BEHAVIOR LA English DT Article DE High glycemic load; Low glycemic load; Mood; Cognition; Energy metabolism ID RANDOMIZED CONTROLLED-TRIAL; LOW-FAT DIET; OBESE YOUNG-ADULTS; WEIGHT-LOSS; LOW-CARBOHYDRATE; BODY-COMPOSITION; FEEDING-BEHAVIOR; OVERWEIGHT WOMEN; PERFORMANCE; BREAKFASTS AB Energy-restricted low glycemic load diets are being used increasingly for weight loss. However, the long-term effects of such regimens on mood and cognitive performance are not known. We assessed the effects of low glycemic load (LG) and high glycemic load (HG) energy-restricted diets on mood and cognitive performance during 6 months of a randomized controlled trial when all food was provided. Subjects were 42 healthy overweight adults (age 35 5 years; BMI 27.8 +/- 1.6 kg/m(2)) with a mean weight loss of 8.7 +/- 5.0% that did not differ significantly by diet randomization. Mood was assessed by using the Profile of Mood States (POMS) questionnaire. Cognitive performance was assessed by using computerized tests of simple reaction time, vigilance, learning, short-term memory and attention, and language-based logical reasoning. Worsening mood outcome over time was observed in the HG diet group compared to the LG for the depression subscale of POMS (p=0.009 after including hunger as a covariate). There was no significant change over time in any cognitive performance values. These findings suggest a negative effect of an HG weight loss diet on sub-clinical depression but, in contrast to a previous suggestion, provide no support for differential effects of LG versus HD diets on cognitive performance. (c) 2009 Elsevier Inc. All rights reserved. C1 [Roberts, Susan B.] Tufts Univ, Human Nutr Res Ctr Aging, Energy Metab Lab, Jean Mayer USDA, Boston, MA 02111 USA. [Hyatt, Raymond] Tufts Univ, Sch Med, Boston, MA 02111 USA. [Lerner, Debra] Tufts Univ New England Med Ctr, Inst Clin Res & Hlth Policy Studies, Boston, MA USA. [Lieberman, Harris R.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. RP Roberts, SB (reprint author), Tufts Univ, Human Nutr Res Ctr Aging, Energy Metab Lab, Jean Mayer USDA, 711 Washington St, Boston, MA 02111 USA. EM susan.roberts@tufts.edu RI Hyatt, Raymond/A-1533-2009 FU National Institutes of Health [U01-AG20480]; U.S. Department of Agriculture [58-1950-4-401]; National Institutes of Diabetes and Digestive and Kidney Diseases [K23 DK61506]; Boston Obesity Nutrition Research Center (BONRC) [H150001]; NIH T32 [DK62032-11] FX We thank our volunteers for their dedicated participation in the study, and the outstanding staff of the metabolic research unit for their expert help. Supported by National Institutes of Health grant U01-AG20480, U.S. Department of Agriculture under agreement No. 58-1950-4-401, K23 DK61506 from the National Institutes of Diabetes and Digestive and Kidney Diseases, and Boston Obesity Nutrition Research Center (BONRC) H150001. R Cheatham was supported by a NIH T32 grant (#DK62032-11). Any opinions, findings, conclusion, or recommendations expressed in this publication are those of the authors and do not necessarily reflect the view of the U.S. Department of Agriculture, the Food and Drug Administration or the U.S. Army. NR 63 TC 22 Z9 23 U1 3 U2 21 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD SEP 7 PY 2009 VL 98 IS 3 BP 374 EP 379 DI 10.1016/j.physbeh.2009.06.015 PG 6 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA 491IH UT WOS:000269571600019 PM 19576915 ER PT J AU Burbank, W Witmer, D Holcomb, F AF Burbank, Winston, Jr. Witmer, Dennis Holcomb, Frank TI Model of a novel pressurized solid oxide fuel cell gas turbine hybrid engine SO JOURNAL OF POWER SOURCES LA English DT Article DE SOFC; Solid oxide fuel cell; Gas turbine; Hybrid; Engine; High efficiency; Turndown; Off-design; Model; Steady-state ID PART-LOAD PERFORMANCE; SYSTEM; OPERATION; DESIGN AB Solid oxide fuel cell gas turbine (SOFC-GT) hybrid systems for producing electricity have received much attention due to high-predicted efficiencies, low pollution and availability of natural gas. Due to the higher value of peak power. a system able to meet fluctuating power demands while retaining high efficiencies is strongly preferable to base load operation. SOFC systems and hybrid variants designed to date have had narrow operating ranges due largely to the necessity of heat management within the fuel cell. Such systems have a single degree of freedom controlled and limited by the fuel cell. This study will introduce a new SOFC-GT hybrid configuration designed to operate over a 5:1 turndown ratio, while maintaining the SOFC stack exit temperature at a constant 1000 degrees C. The proposed system introduces two new degrees of freedom through the use of a variable-geometry nozzle turbine to directly influence system airflow, and an auxiliary combustor to control the thermal and power needs of the turbomachinery. (C) 2009 Elsevier B.V. All rights reserved. C1 [Burbank, Winston, Jr.; Witmer, Dennis] Univ Alaska Fairbanks, Alaska Ctr Energy & Power, Fairbanks, AK USA. [Holcomb, Frank] USA, Engineer Res & Dev Ctr, Res Lab, Champaign, IL USA. RP Burbank, W (reprint author), Univ Alaska Fairbanks, Alaska Ctr Energy & Power, Fairbanks, AK USA. EM Winston.Burbank@gmail.com FU Department of Defense [W9132T-04-2-007] FX Thanks to the Department of Defense for sponsoring the work presented above through contract number W9132T-04-2-007. The content of this report does not necessarily represent the position or policy of the government and no official endorsement should be inferred. NR 39 TC 31 Z9 31 U1 0 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD SEP 5 PY 2009 VL 193 IS 2 BP 656 EP 664 DI 10.1016/j.jpowsour.2009.04.004 PG 9 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 477LR UT WOS:000268521100039 ER PT J AU Gaston, JSH Inman, RD Ryan, ET Venkatesan, MM Barry, EM Hale, TL Bourgeois, AL Walker, RI AF Gaston, J. S. Hill Inman, Robert D. Ryan, Edward T. Venkatesan, Malabi M. Barry, Eileen M. Hale, Thomas L. Bourgeois, A. Louis Walker, Richard I. TI Vaccination of children in low-resource countries against Shigella is unlikely to present an undue risk of reactive arthritis SO VACCINE LA English DT Letter DE Reactive arthritis; Shigellosis; Vaccination ID INFECTION; HLA-B27; ASSOCIATION AB Shigellosis is a major cause of morbidity and mortality among children in low-resource countries. Promising vaccine strategies in development include genetically attenuated Shigella, killed whole cell vaccines, subcellular vaccines, and O-polysaccharide-protein conjugates. There is a concern that Shigella vaccines could either induce reactive arthritis or could prime vaccinees for arthritis after a subsequent exposure to the pathogen because shigellosis is associated with reactive arthritis, especially in patients expressing the HLA B27 histocompatibility antigen. Our understanding of the pathogenesis of reactive arthritis is incomplete, and even surrogate biomarkers of bacterial arthritogenic activity have not yet been identified. Nonetheless, all of the Shigella vaccine strategies currently in development are designed to limit inflammation and intracellular antigen persistence that could trigger arthritogenic sequelae. The relatively low occurrence of the HLA B27 phenotype in most Shigella endemic areas, and the rarity of reported reactive arthritis in these populations, suggests that vaccination with attenuated, killed, or subcellular vaccines may not increase the background incidence of arthritic sequelae. More importantly, incidence rates of shigellosis in children living in low-resource countries suggest that, during maturation, the entire pediatric population may be infected with Shigella-possibly with devastating consequences. Therefore, clinical trials of candidate Shigella vaccines should be pursued aggressively in the developing world, beginning with a Phase 1 in HLA B27-negative volunteers, but proceeding to Phase 2 and Phase 3 in unscreened volunteers. Post-vaccination monitoring for possible reactive arthritis should be included in all clinical protocols. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Hale, Thomas L.; Bourgeois, A. Louis; Walker, Richard I.] PATH, Enter Vaccine Initiat, Vaccine Dev Global Program, Washington, DC USA. [Gaston, J. S. Hill] Univ Cambridge, Addenbrookes Hosp, Cambridge CB2 2QQ, England. [Inman, Robert D.] Univ Toronto, Toronto Western Res Inst, Toronto, ON, Canada. [Ryan, Edward T.] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA. [Venkatesan, Malabi M.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD USA. [Barry, Eileen M.] Univ Maryland, Sch Med, Ctr Vaccine Dev, Baltimore, MD 21201 USA. RP Walker, RI (reprint author), PATH, Enter Vaccine Initiat, Vaccine Dev Global Program, 1800 K St NW,Suite 800, Washington, DC USA. EM rwalker@path.org NR 11 TC 3 Z9 3 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD SEP 4 PY 2009 VL 27 IS 40 BP 5432 EP 5434 DI 10.1016/j.vaccine.2009.06.107 PG 3 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 492TP UT WOS:000269682800003 PM 19643213 ER PT J AU Garza, NL Hatkin, JM Livingston, V Nichols, DK Chaplin, PJ Volkmann, A Fisher, D Nalca, A AF Garza, Nicole L. Hatkin, Josh M. Livingston, Virginia Nichols, Donald K. Chaplin, Paul J. Volkmann, Ariane Fisher, Diana Nalca, Aysegul TI Evaluation of the efficacy of modified vaccinia Ankara (MVA)/IMVAMUNE (R) against aerosolized rabbitpox virus in a rabbit model SO VACCINE LA English DT Article DE Rabbitpox virus; Aerosol; IMVAMUNE (R); MVA; Smallpox vaccine ID ATTENUATED SMALLPOX VACCINE; IMMUNOLOGICAL RESPONSES; IMMUNOGENICITY; INFECTION; MVA; PROTECTION; CHALLENGE; MONKEYPOX; IMVAMUNE; DRYVAX AB Infection of rabbits with aerosolized rabbitpox virus (RPXV) produces a disease similar to monkeypox and smallpox in humans and provides a valuable, informative model system to test medical countermeasures against orthopoxviruses. Due to the eradication of smallpox, the evaluation of the efficacy of new-generation smallpox vaccines depends on relevant well-developed animal studies for vaccine licensure. In this study, we tested the efficacy of IMVAMUNE (R) [modified vaccinia Ankara-Bavarian Nordic (MVA-BN (R))] for protecting rabbits against aerosolized RPXV. Rabbits were vaccinated with either phosphate-buffered saline (PBS), Dryvax (R), a single low dose of IMVAMUNE (R), a single high dose of IMVAMUNE (R), or twice with a high dose of IMVAMUNE (R). Aerosol challenge with a lethal dose of RPXV was performed 4 weeks after the last vaccination. All PBS control animals succumbed to the disease or were euthanized because of the disease within 7 days postexposure. The rabbits vaccinated with Dryvax (R), a low dose of IMVAMUNE (R), or a single high dose of IMVAMUNE (R) showed minimal to moderate clinical signs of the disease, but all survived the challenge. The only clinical sign displayed by rabbits that had been vaccinated twice with a high dose of IMVAMUNE (R) was mild transient anorexia in just two out of eight rabbits. This study shows that IMVAMUNE (R) can be a very effective vaccine against aerosolized RPXV. Published by Elsevier Ltd. C1 [Garza, Nicole L.; Hatkin, Josh M.; Livingston, Virginia; Nalca, Aysegul] USA, Ctr Aerobiol Sci, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Nichols, Donald K.] USA, Div Pathol, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Fisher, Diana] USA, Res Support Div, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Chaplin, Paul J.; Volkmann, Ariane] Bavarian Nord GmbH, D-82152 Martinsried, Germany. RP Nalca, A (reprint author), USA, Ctr Aerobiol Sci, Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA. EM aysegul.nalca@us.army.mil FU Office of Biodefense Research Affairs (OBRA)/National Institute of Allergy and Infectious Diseases (NIAID); USAMRIID FX This study was supported by an interagency agreement between Office of Biodefense Research Affairs (OBRA)/National Institute of Allergy and Infectious Diseases (NIAID) and USAMRIID. NR 24 TC 24 Z9 24 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD SEP 4 PY 2009 VL 27 IS 40 BP 5496 EP 5504 DI 10.1016/j.vaccine.2009.06.105 PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 492TP UT WOS:000269682800011 PM 19632316 ER PT J AU Wu, PC Khoury, CG Kim, TH Yang, Y Losurdo, M Bianco, GV Vo-Dinh, T Brown, AS Everitt, HO AF Wu, Pae C. Khoury, Christopher G. Kim, Tong-H Yang, Yang Losurdo, Maria Bianco, Giuseppe V. Vo-Dinh, Tuan Brown, April S. Everitt, Henry O. TI Demonstration of Surface-Enhanced Raman Scattering by Tunable, Plasmonic Gallium Nanoparticles SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Article ID SILVER NANOPARTICLES; SPECTROSCOPY AB Size-controlled gallium nanoparticles deposited on sapphire were explored as alternative substrates to enhance Raman spectral signatures. Gallium's resilience following oxidation is inherently advantageous in comparison with silver for practical ex vacuo nonsolution applications. Ga nanoparticles were grown using a simple molecular beam epitaxy-based fabrication protocol, and monitoring their corresponding surface plasmon resonance energy through in situ spectroscopic ellipsometry allowed the nanoparticles to be easily controlled for size. The Raman spectra obtained from cresyl fast violet (CFV) deposited on substrates with differing mean nanoparticle sizes represent the first demonstration of enhanced Raman signals from reproducibly tunable self-assembled Ga nanoparticles. Nonoptimized aggregate enhancement factors of similar to 80 were observed from the substrate with the smallest Ga nanoparticles for CFV dye solutions down to a dilution of 10 ppm. C1 [Wu, Pae C.; Kim, Tong-H; Losurdo, Maria; Brown, April S.; Everitt, Henry O.] Duke Univ, Dept Elect & Comp Engn, Durham, NC 27708 USA. [Khoury, Christopher G.; Vo-Dinh, Tuan; Brown, April S.] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA. [Yang, Yang; Everitt, Henry O.] Duke Univ, Dept Phys, Durham, NC 27708 USA. [Losurdo, Maria; Bianco, Giuseppe V.] CNR, Inst Inorgan Methodol & Plasmas IMIP, I-70126 Bari, Italy. [Everitt, Henry O.] USA, Aviat & Missile RD&E Ctr, Redstone Arsenal, AL 35898 USA. RP Wu, PC (reprint author), Duke Univ, Dept Elect & Comp Engn, Durham, NC 27708 USA. EM pae.wu@duke.edu RI Everitt, Henry/L-7118-2013; OI Everitt, Henry/0000-0002-8141-3768; BIANCO, GIUSEPPE VALERIO/0000-0002-0986-1531; LOSURDO, MARIA/0000-0002-8008-5192 FU U.S. Army's competitive in-house innovative research program; National Institutes of Health [R01 EB006201] FX This work was partially supported by the U.S. Army's competitive in-house innovative research program and the National Institutes of Health (R01 EB006201). The authors thank Jon Scaffidi for helpful discussions. H.O.E. thanks R. Van Duyne for his supportive comments during the early phases of this project. NR 11 TC 33 Z9 33 U1 3 U2 35 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD SEP 2 PY 2009 VL 131 IS 34 BP 12032 EP + DI 10.1021/ja903321z PG 4 WC Chemistry, Multidisciplinary SC Chemistry GA 488VY UT WOS:000269379600006 PM 19655747 ER PT J AU Ryan, KL Loeppky, JA Kilgore, DE AF Ryan, Kathy L. Loeppky, Jack A. Kilgore, Donald E., Jr. TI A forgotten moment in physiology: the Lovelace Woman in Space Program (1960-1962) SO ADVANCES IN PHYSIOLOGY EDUCATION LA English DT Editorial Material DE gender differences; history of physiology; space physiology ID ASTRONAUTS; SELECTION AB Ryan KL, Loeppky JA, Kilgore DE Jr. A forgotten moment in physiology: the Lovelace Woman in Space Program (1960-1962). Adv Physiol Educ 33: 157-164, 2009; doi: 10.1152/advan.00034.2009.-In 1959, Brigadier General Donald Flickinger and Dr. W. Randolph Lovelace II suggested that it would be more practical from an engineering standpoint to send women rather than men into space due to their lower body weights and oxygen requirements. When the Air Force decided not to pursue this project, Dr. Lovelace assumed leadership of the Woman in Space Program and began medical and physiological testing of a series of accomplished women aviators at the Lovelace Medical Clinic in Albuquerque, NM, in 1960. The tests that these women underwent were identical to those used to test the original Mercury astronauts, with the addition of gynecological examinations. Thirteen of the nineteen women tested passed these strenuous physiological exams (for comparison, 18 of 32 men tested passed); a subset of these pilots was further tested on a series of psychological exams that were similar to or, in some instances, more demanding than those given to male Mercury candidates. Despite these promising results, further testing was halted, and the Woman in Space Program was disbanded in 1962. Although the Woman in Space Program received a great deal of publicity at the time, the story of these women was somewhat lost until they were reunited at the 1999 launch of the shuttle Columbia, commanded by Colonel Eileen Collins. C1 [Ryan, Kathy L.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Loeppky, Jack A.] Vet Affairs Med Ctr, Res Sect, Albuquerque, NM USA. [Kilgore, Donald E., Jr.] Lovelace Fdn Med Educ & Res, Albuquerque, NM 87108 USA. RP Ryan, KL (reprint author), USA, Inst Surg Res, Bldg 3611,3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM Kathy.ryan@amedd.army.mil NR 20 TC 0 Z9 0 U1 0 U2 1 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 1043-4046 J9 ADV PHYSIOL EDUC JI Adv. Physiol. Educ. PD SEP PY 2009 VL 33 IS 3 BP 157 EP 164 DI 10.1152/advan.00034.2009 PG 8 WC Education, Scientific Disciplines; Physiology SC Education & Educational Research; Physiology GA 493EQ UT WOS:000269717300003 PM 19745040 ER PT J AU Webb, LM Mikita, CP AF Webb, Luke M. Mikita, Cecilia P. TI Solar urticaria SO ALLERGY AND ASTHMA PROCEEDINGS LA English DT Article DE Chromophore; dermatographism; erythrocytic protoporphyria; minimal urticarial dose; photodermatoses; phototherapy; physical urticaria; polymorphic light eruption; solar urticaria AB A case of solar urticaria is presented, followed by a discussion of the clinical characteristics, pathophysiology, diagnosis, and management of this disease. Special emphasis is given to clinical pearls and pitfalls for the practicing allergist. Solar urticaria is a physical urticaria that can be difficult to diagnose and distinguish from other photodermatoses, There are some characteristic features that are important to remember when evaluating a patient with suspected solar urticaria. Testing call be difficult without the assistance of an experienced dermatologist because there are several different wavelengths of light that call lead to a patient's symptoms. Solar urticaria tends to be a chronic disease with a low 5-year resolution rate but call usually be effectively managed with multiple antihistamines. (Allergy Asthma Proc 30:563-565, 2009; doi: 10.2500/aap.2009.30.3273) C1 [Webb, Luke M.; Mikita, Cecilia P.] Walter Reed Army Med Ctr, Dept Allergy & Immunol, Washington, DC 20307 USA. [Mikita, Cecilia P.] Uniformed Serv Univ Hlth Sci, Dept Pediat & Med, Bethesda, MD 20814 USA. RP Webb, LM (reprint author), Walter Reed Army Med Ctr, Dept Allergy & Immunol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM luke.webb@us.army.mil NR 11 TC 1 Z9 2 U1 0 U2 2 PU OCEAN SIDE PUBLICATIONS INC PI PROVIDENCE PA 95 PITMAN ST, PROVIDENCE, RI 02906 USA SN 1088-5412 J9 ALLERGY ASTHMA PROC JI Allergy Asthma Proc. PD SEP-OCT PY 2009 VL 30 IS 5 BP 563 EP 565 DI 10.2500/aap.2009.30.3273 PG 3 WC Allergy SC Allergy GA 508TQ UT WOS:000270959700016 PM 19843410 ER PT J AU Young, SE Miller, MA Docherty, M AF Young, Scott E. Miller, Michael A. Docherty, Martin TI Urine dipstick testing to rule out rhabdomyolysis in patients with suspected heat injury SO AMERICAN JOURNAL OF EMERGENCY MEDICINE LA English DT Article AB Background: Heat injury is a common, potentially life-threatening medical condition. In austere or mass-casualty conditions an easy to use, sensitive screening test could be a valuable tool to care providers and evacuation planners. Objective: The objective of the study was to determine if a simple urine dipstick test for blood is sensitive for detection of rhabdomyolysis in the suspected heat injury patient. Material and Methods: A convenience sample of patients presenting to a military community hospital Emergency Department during summer months with a presenting complaint consistent with suspected heat injury had urine dipstick testing performed for blood and compared with the results of formal urinalysis and serum creatine kinase. Results: 60 patients were enrolled in the study, seven had creatine kinase levels greater than 1000U/L, 14 had levels greater than 500U/L, and 26 had levels greater than 250 U/L. Using 1000U/L, urine dipstick testing had a sensitivity of 14% and a specificity of 85%. Conclusions: Urine dipstick testing for blood is not a useful screening test for rhabdomyolysis in patients suspected to have significant heat injury. (C) 2009 Published by Elsevier Inc. C1 [Miller, Michael A.] Tripler Army Med Ctr, Dept Emergency Med, Honolulu, HI 96859 USA. [Young, Scott E.; Miller, Michael A.; Docherty, Martin] Darnall Army Med Ctr, Dept Emergency Med, Ft Hood, TX 76544 USA. [Miller, Michael A.] Cent Texas Poison Control Ctr, Temple, TX 76508 USA. RP Miller, MA (reprint author), Tripler Army Med Ctr, Dept Emergency Med, Honolulu, HI 96859 USA. EM michael.adam.milller@us.army.mil NR 5 TC 4 Z9 4 U1 1 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0735-6757 J9 AM J EMERG MED JI Am. J. Emerg. Med. PD SEP PY 2009 VL 27 IS 7 BP 875 EP 877 DI 10.1016/j.ajem.2008.06.020 PG 3 WC Emergency Medicine SC Emergency Medicine GA 487XK UT WOS:000269311400022 PM 19683121 ER PT J AU Bartz, C AF Bartz, Claudia TI ARMY NURSES SO AMERICAN JOURNAL OF NURSING LA English DT Letter C1 USA, Milwaukee, WI USA. RP Bartz, C (reprint author), USA, Milwaukee, WI USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0002-936X J9 AM J NURS JI Am. J. Nurs. PD SEP PY 2009 VL 109 IS 9 BP 12 EP + PG 2 WC Nursing SC Nursing GA 490IU UT WOS:000269495200006 PM 19704213 ER PT J AU Owens, AB Canas, LC Russell, KL Neville, JS Pavlin, JA MacIntosh, VH Gray, GC Gaydos, JC AF Owens, Angela B. Canas, Linda C. Russell, Kevin L. Neville, James S. Pavlin, Julie A. MacIntosh, Victor H. Gray, Gregory C. Gaydos, Joel C. TI Department of Defense Global Laboratoty-Based Influenza Surveillance 1998-2005 SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID US MILITARY; VACCINES AB The Department of Defense (DoD) Global Laboratory Based Influenza Surveillance Program was initiated in 1997 to formally consolidate and expand existing influenza surveillance programs within the DoD and in areas where DoD was working. Substantial changes in 2008 provided an opportunity to review the operation of the Surveillance program as it existed during seven complete influenza seasons (1998-2005); the review was conducted in 2008. A unique aspect of the DoD program was the global reach for specimen collection and the ability to rapidly ship, process, and evaluate specimens from 27 countries. The resulting epidemiologic data combined with the culture results from >46,000 patients provided information that was shared with similar national and international programs, such as those of the CDC. Likewise, selected influenza isolates were molecularly characterized and shared with the CDC to be compared with other surveillance programs. Timeliness of the samples contributed to the information available for annual influenza vaccine selection. (Am J Prev Med 2009;37(3):235-241) Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine C1 [Owens, Angela B.; Canas, Linda C.; Neville, James S.; MacIntosh, Victor H.] USAF, Sch Aerosp Med, Brooks City Base, TX 78235 USA. [Russell, Kevin L.; Gaydos, Joel C.] AFHSC, Dept Def Global Emerging Infect Surveillance & Re, Silver Spring, MD USA. [Pavlin, Julie A.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Gray, Gregory C.] Univ Iowa, Coll Publ Hlth, Iowa City, IA USA. RP Neville, JS (reprint author), USAF, Sch Aerosp Med, 2513 Kennedy Circle, Brooks City Base, TX 78235 USA. EM james.neville@us.af.mil NR 24 TC 16 Z9 16 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD SEP PY 2009 VL 37 IS 3 BP 235 EP 241 DI 10.1016/j.amepre.2009.04.022 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 487RA UT WOS:000269291300011 PM 19666159 ER PT J AU Owens, BD Agel, J Mountcastle, SB Cameron, KL Nelson, BJ AF Owens, Brett D. Agel, Julie Mountcastle, Sally B. Cameron, Kenneth L. Nelson, Bradley J. TI Incidence of Glenohumeral Instability in Collegiate Athletics SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE shoulder instability; dislocation; athlete ID SHOULDER DISLOCATION; INJURY PATTERNS; UNITED-STATES; EPIDEMIOLOGY; FOOTBALL; PREVALENCE AB Background: Glenohumeral instability is a common injury sustained by young athletes. Surprisingly, little is known regarding the incidence of glenohumeral instability in collegiate athletes or the relevant risk factors for injury. A better understanding of the populations most at risk may be used to develop preventive strategies. Hypothesis: The incidence of glenohumeral instability in collegiate athletics is high, and it is affected by sex, sport, type of event, and mechanism of injury. Study Design: Descriptive epidemiologic study. Methods: The National Collegiate Athletic Association injury database was queried for all glenohumeral instability events occurring between the years 1989 and 2004. An analysis of the injuries was performed by sport, activity (competition versus practice), sex, type of event (primary versus recurrent), mechanism of injury, and time loss from athletic performance. Incidence rates and incidence rate ratios were calculated. Results: A total of 4080 glenohumeral instability events were documented for an incidence rate of 0.12 injuries per 1000 athlete exposures. The sport with the greatest injury rate was men's spring football, with 0.40 injuries per 1000 athlete exposures. Overall, athletes sustained more glenohumeral instability events during games than practices (incidence rate ratio [IRR], 3.50; 95% confidence interval [CI], 3.29-3.73). Male athletes sustained more injuries than did female athletes (IRR, 2.67; 95% Cl, 2.43-2.93). Female athletes were more likely to sustain an instability event as the result of contact with an object (IRR, 2.43; 95% Cl, 2.08-2.84), whereas male athletes were more likely to sustain an event from player contact (IRR, 2.74; 95% Cl, 2.31-3.25). Time lost to sport (>10 days) occurred in 45% of glenohumeral instability events. Conclusion: Glenohumeral instability is a relatively common injury sustained by collegiate athletes. More injuries occurred during competition and among male athletes. C1 [Owens, Brett D.] William Beaumont Army Med Ctr, Div Orthopaed Surg, El Paso, TX 79920 USA. [Agel, Julie; Nelson, Bradley J.] Univ Minnesota, Dept Orthopaed Surg, Minneapolis, MN 55455 USA. [Mountcastle, Sally B.] Univ Texas El Paso, El Paso, TX 79968 USA. [Cameron, Kenneth L.] Keller Army Hosp, Dept Orthopaed Surg, West Point, NY USA. RP Owens, BD (reprint author), William Beaumont Army Med Ctr, Div Orthopaed Surg, 5005 N Piedras St, El Paso, TX 79920 USA. EM b.owens@us.army.mil OI Cameron, Kenneth/0000-0002-6276-4482 NR 15 TC 50 Z9 52 U1 0 U2 2 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD SEP PY 2009 VL 37 IS 9 BP 1750 EP 1754 DI 10.1177/0363546509334591 PG 5 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 487FO UT WOS:000269256500011 PM 19556471 ER PT J AU Gottfried, JL De Lucia, FC Munson, CA Miziolek, AW AF Gottfried, Jennifer L. De Lucia, Frank C., Jr. Munson, Chase A. Miziolek, Andrzej W. TI Laser-induced breakdown spectroscopy for detection of explosives residues: a review of recent advances, challenges, and future prospects SO ANALYTICAL AND BIOANALYTICAL CHEMISTRY LA English DT Review DE Explosives detection; Laser-induced breakdown spectroscopy; Double-pulse LIBS; Chemometric analysis ID INDUCED PLASMA SPECTROSCOPY; DUAL-PULSE LIBS; ND-YAG LASER; RAMAN-SPECTROSCOPY; MULTIVARIATE-ANALYSIS; INDUCED FLUORESCENCE; ENERGETIC MATERIALS; ORGANIC-COMPOUNDS; PHOTOACOUSTIC-SPECTROSCOPY; SPECTROCHEMICAL ANALYSIS AB In this review we discuss the application of laser-induced breakdown spectroscopy (LIBS) to the problem of detection of residues of explosives. Research in this area presented in open literature is reviewed. Both laboratory and field-tested standoff LIBS instruments have been used to detect explosive materials. Recent advances in instrumentation and data analysis techniques are discussed, including the use of double-pulse LIBS to reduce air entrainment in the analytical plasma and the application of advanced chemometric techniques such as partial least-squares discriminant analysis to discriminate between residues of explosives and non-explosives on various surfaces. A number of challenges associated with detection of explosives residues using LIBS have been identified, along with their possible solutions. Several groups have investigated methods for improving the sensitivity and selectivity of LIBS for detection of explosives, including the use of femtosecond-pulse lasers, supplemental enhancement of the laser-induced plasma emission, and complementary orthogonal techniques. Despite the associated challenges, researchers have demonstrated the tremendous potential of LIBS for real-time detection of explosives residues at standoff distances. C1 [Gottfried, Jennifer L.; De Lucia, Frank C., Jr.; Munson, Chase A.; Miziolek, Andrzej W.] USA, Res Lab, AMSRD ARL WM BD, Aberdeen Proving Ground, MD 21005 USA. RP Gottfried, JL (reprint author), USA, Res Lab, AMSRD ARL WM BD, Aberdeen Proving Ground, MD 21005 USA. EM jennifer.gottfried@us.army.mil RI Gottfried, Jennifer/G-6333-2010; De Lucia, Frank/D-5630-2012; Munson, Chase/H-1667-2012 NR 142 TC 157 Z9 162 U1 10 U2 97 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1618-2642 EI 1618-2650 J9 ANAL BIOANAL CHEM JI Anal. Bioanal. Chem. PD SEP PY 2009 VL 395 IS 2 BP 283 EP 300 DI 10.1007/s00216-009-2802-0 PG 18 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 483XL UT WOS:000269006500005 PM 19418042 ER PT J AU Kunz, RR Gregory, KC Hardy, D Oyler, J Ostazeski, SA Fountain, AW AF Kunz, Roderick R. Gregory, Kerin Clow Hardy, Dennis Oyler, Jonathan Ostazeski, Stanley A. Fountain, Augustus Way, III TI Measurement of trace explosive residues in a surrogate operational environment: implications for tactical use of chemical sensing in C-IED operations SO ANALYTICAL AND BIOANALYTICAL CHEMISTRY LA English DT Article DE Explosives detection; Background clutter; Trace residue; Improvised explosive device; TNT; RDX AB A campaign to measure the amount of trace explosive residues in an operational military environment was conducted on May 27-31, 2007, at the National Training Center at Fort Irwin, CA, USA. The objectives of this campaign were to develop the methods needed to collect and analyze samples from tactical military settings, to use the data obtained to determine what the trace explosive signatures suggest about the potential capabilities of chemical-based means to detect IEDs, and, finally, to present a framework whereby a sound understanding of the signature science can be used to guide development of new sensing technologies and sensor concepts of operation. Through our use of combined background and threat signature data, we have performed statistical analyses to estimate upper limits of notional sensor performance that is limited only by the spatial correlation of the signature chemicals to the threats of interest. C1 [Oyler, Jonathan; Ostazeski, Stanley A.; Fountain, Augustus Way, III] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Kunz, Roderick R.; Gregory, Kerin Clow; Hardy, Dennis] MIT, Lincoln Lab, Lexington, MA 02173 USA. RP Fountain, AW (reprint author), USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM augustus.w.fountain@us.army.mil FU JIEDDO/ECBC [FA8721-050C-0002] FX The Lincoln Laboratory portion of this work was sponsored by JIEDDO/ECBC under Air Force Contract FA8721-050C-0002. Portions of this work, both in the laboratory and field, could not have been completed without the assistance of Dr. Michael Switkes and Mr. Keith Krohn of MIT-LL and Mr. Robert Calloway, Mr. John Sparks, Ms. Jennifer P. Exelby, Ms. Melissa Mullan, Mr. Tom Rusek (Battelle), Mr. J. Greene (Battelle), and Mr. Douglas Nichols ( Battelle) of the ECBC, Forensics Analysis Center. NR 8 TC 7 Z9 7 U1 1 U2 9 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1618-2642 J9 ANAL BIOANAL CHEM JI Anal. Bioanal. Chem. PD SEP PY 2009 VL 395 IS 2 BP 357 EP 369 DI 10.1007/s00216-009-2748-2 PG 13 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 483XL UT WOS:000269006500011 PM 19340417 ER PT J AU Beckmann, B Mehta, S Hilliard, M AF Beckmann, B. Mehta, S. Hilliard, M. TI Bedside Teaching in an Academic Emergency Department SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT American-College-of-Emergency-Physicians Forum 2009 CY OCT 05-06, 2009 CL Boston, MA SP Amer Coll Emergency Phys, Boston Exhibit & Convent Ctr C1 [Beckmann, B.; Mehta, S.; Hilliard, M.] Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD SEP PY 2009 VL 54 IS 3 SU S BP S125 EP S125 PG 1 WC Emergency Medicine SC Emergency Medicine GA 488JO UT WOS:000269346100398 ER PT J AU De Lorenzo, RA Rubal, BJ Ward, JA Jordan, BS Hanson, CE Holbrook-Emmons, VL Medina, JS AF De Lorenzo, R. A. Rubal, B. J. Ward, J. A. Jordan, B. S. Hanson, C. E. Holbrook-Emmons, V. L. Medina, J. S. TI Visualization of Intraosseous Flow Paths by Angiography, Computed Tomography and Vital Dye Techniques SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT American-College-of-Emergency-Physicians Forum 2009 CY OCT 05-06, 2009 CL Boston, MA SP Amer Coll Emergency Phys, Boston Exhibit & Convent Ctr C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD SEP PY 2009 VL 54 IS 3 SU S BP S99 EP S99 PG 1 WC Emergency Medicine SC Emergency Medicine GA 488JO UT WOS:000269346100316 ER PT J AU Goo, R Miller, M Coon, TP AF Goo, R. Miller, M. Coon, T. P. TI Provider Compliance With the Food and Drug Administration Recommendation to Avoid the Use of Over the Counter (Nonprescription) Cough and Cold Medications in Children Under Two Years Old SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT American-College-of-Emergency-Physicians Forum 2009 CY OCT 05-06, 2009 CL Boston, MA SP Amer Coll Emergency Phys, Boston Exhibit & Convent Ctr C1 [Goo, R.; Miller, M.; Coon, T. P.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD SEP PY 2009 VL 54 IS 3 SU S BP S42 EP S42 PG 1 WC Emergency Medicine SC Emergency Medicine GA 488JO UT WOS:000269346100135 ER PT J AU Greenfield, EM McManus, J Cooke, WH Pittman, D Shiver, SA Beatty, J Croushorn, J Schwartz, R AF Greenfield, E. M. McManus, J. Cooke, W. H. Pittman, D. Shiver, S. A. Beatty, J. Croushorn, J. Schwartz, R. TI Safety and Efficacy of a Novel Abdominal Aortic Tourniquet Device for the Control of Pelvic and Lower Extremity Hemorrhage SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT American-College-of-Emergency-Physicians Forum 2009 CY OCT 05-06, 2009 CL Boston, MA SP Amer Coll Emergency Phys, Boston Exhibit & Convent Ctr C1 Med Coll Georgia, Augusta, GA 30912 USA. USA, Med Dept Ctr & Sch, Ft Sam Houston, TX USA. Univ Texas San Antonio, San Antonio, TX USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD SEP PY 2009 VL 54 IS 3 SU S BP S62 EP S62 PG 1 WC Emergency Medicine SC Emergency Medicine GA 488JO UT WOS:000269346100201 ER PT J AU Miller, J Lairet, J DeLorenzo, R Pitotti, R AF Miller, J. Lairet, J. DeLorenzo, R. Pitotti, R. TI Intraosseous Infusion of Crystalloid Fluid Immediately After Intraosseous Infusion of Nitroglycerin in the Proximal Tibia of a Swine (Sus Scrofa) Model SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT American-College-of-Emergency-Physicians Forum 2009 CY OCT 05-06, 2009 CL Boston, MA SP Amer Coll Emergency Phys, Boston Exhibit & Convent Ctr C1 Wilford Hall USAF Med Ctr, San Antonio, TX 78236 USA. Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD SEP PY 2009 VL 54 IS 3 SU S BP S140 EP S140 PG 1 WC Emergency Medicine SC Emergency Medicine GA 488JO UT WOS:000269346100447 ER PT J AU Morton, MJ Kirsch, TD Rothman, RE Hsieh, Y Byerly, MM McManus, JG Kelen, GD AF Morton, M. J. Kirsch, T. D. Rothman, R. E. Hsieh, Y. Byerly, M. M. McManus, J. G. Kelen, G. D. TI The Impact of Emergency Department Size on Pandemic Influenza Preparedness in US Emergency Departments SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT American-College-of-Emergency-Physicians Forum 2009 CY OCT 05-06, 2009 CL Boston, MA SP Amer Coll Emergency Phys, Boston Exhibit & Convent Ctr C1 Johns Hopkins Univ, Sch Med, Baltimore, MD USA. Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD SEP PY 2009 VL 54 IS 3 SU S BP S123 EP S124 PG 2 WC Emergency Medicine SC Emergency Medicine GA 488JO UT WOS:000269346100394 ER PT J AU Olderog, CK Schmitz, G Pitotti, R Williams, J Huebner, K Livengood, T Ritz, B AF Olderog, C. K. Schmitz, G. Pitotti, R. Williams, J. Huebner, K. Livengood, T. Ritz, B. TI Double-Blind, Randomized, Controlled Multi-Center Trial of Antibiotic Treatment for Uncomplicated Skin Abscesses in Patients at Risk for Community-Acquired Methicillin-Resistant Staphylococcus aureus Infection: An Interim Analysis SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT American-College-of-Emergency-Physicians Forum 2009 CY OCT 05-06, 2009 CL Boston, MA SP Amer Coll Emergency Phys, Boston Exhibit & Convent Ctr C1 Brooke Army Med Ctr, San Antonio, TX USA. Wilford Hall USAF Med Ctr, San Antonio, TX USA. Darnell Army Med Ctr, Killeen, TX USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD SEP PY 2009 VL 54 IS 3 SU S BP S105 EP S105 PG 1 WC Emergency Medicine SC Emergency Medicine GA 488JO UT WOS:000269346100335 ER PT J AU Rubal, BJ Ward, JA Jordan, BS Hanson, CE Medina, JS Holbrook-Emmons, VL De Lorenzo, RA AF Rubal, B. J. Ward, J. A. Jordan, B. S. Hanson, C. E. Medina, J. S. Holbrook-Emmons, V. L. De Lorenzo, R. A. TI A Manometric Method for Evaluating Flow Dynamics and Thrombus Burden of Intraosseous Devices: Theory and Application SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT American-College-of-Emergency-Physicians Forum 2009 CY OCT 05-06, 2009 CL Boston, MA SP Amer Coll Emergency Phys, Boston Exhibit & Convent Ctr C1 [Rubal, B. J.; Ward, J. A.; Jordan, B. S.; Hanson, C. E.; Medina, J. S.; Holbrook-Emmons, V. L.; De Lorenzo, R. A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD SEP PY 2009 VL 54 IS 3 SU S BP S99 EP S99 PG 1 WC Emergency Medicine SC Emergency Medicine GA 488JO UT WOS:000269346100317 ER PT J AU Kragh, JF AF Kragh, John F., Jr. TI Emergency Tourniquet Use Reply SO ANNALS OF SURGERY LA English DT Letter ID MAJOR LIMB TRAUMA C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Kragh, JF (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM john.kragh1@us.army.mil NR 4 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-4932 J9 ANN SURG JI Ann. Surg. PD SEP PY 2009 VL 250 IS 3 BP 497 EP 497 PG 1 WC Surgery SC Surgery GA 488PG UT WOS:000269361400023 ER PT J AU Dai, TH Tegos, GP Lu, ZS Huang, LY Zhiyentayev, T Franklin, MJ Baer, DG Hamblin, MR AF Dai, Tianhong Tegos, George P. Lu, Zongshun Huang, Liyi Zhiyentayev, Timur Franklin, Michael J. Baer, David G. Hamblin, Michael R. TI Photodynamic Therapy for Acinetobacter baumannii Burn Infections in Mice SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID GRAM-NEGATIVE BACTERIA; PSEUDOMONAS-AERUGINOSA; TRANSLOCATION; OPERATIONS; WOUNDS AB Multidrug-resistant Acinetobacter baumannii infections represent a growing problem, especially in traumatic wounds and burns suffered by military personnel injured in Middle Eastern conflicts. Effective treatment with traditional antibiotics can be extremely difficult, and new antimicrobial approaches are being investigated. One of these alternatives to antimicrobials could be the combination of nontoxic photosensitizers (PSs) and visible light, known as photodynamic therapy (PDT). We report on the establishment of a new mouse model of full-thickness thermal burns infected with a bioluminescent derivative of a clinical Iraqi isolate of A. baumannii and its PDT treatment by topical application of a PS produced by the covalent conjugation of chlorin(e6) to polyethylenimine, followed by illumination of the burn surface with red light. Application of 10(8) A. baumannii cells to the surface of 10-s burns made on the dorsal surface of shaved female BALB/c mice led to chronic infections that lasted, on average, 22 days and that were characterized by a remarkably stable bacterial bioluminescence. PDT carried out on day 0 soon after application of the bacteria gave over 3 log units of loss of bacterial luminescence in a light exposure-dependent manner, while PDT carried out on day 1 and day 2 gave an approximately 1.7-log reduction. The application of PS dissolved in 10% or 20% dimethyl sulfoxide without light gave only a modest reduction in the bacterial luminescence from mouse burns. Some bacterial regrowth in the treated burn was observed but was generally modest. It was also found that PDT did not lead to the inhibition of wound healing. The data suggest that PDT may be an effective new treatment for multidrug-resistant localized A. baumannii infections. C1 [Dai, Tianhong; Tegos, George P.; Lu, Zongshun; Huang, Liyi; Zhiyentayev, Timur; Hamblin, Michael R.] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA. [Dai, Tianhong; Tegos, George P.; Huang, Liyi; Hamblin, Michael R.] Harvard Univ, Sch Med, Dept Dermatol, Boston, MA 02115 USA. [Lu, Zongshun] Tianjin Med Univ, Gen Hosp, Dept Gastroenterol, Tianjin, Peoples R China. [Huang, Liyi] Guangxi Med Univ, Affiliated Coll & Hosp 1, Dept Infect Dis, Nanning, Peoples R China. [Zhiyentayev, Timur] Moscow MV Lomonosov State Univ, Dept Chem, Moscow, Russia. [Franklin, Michael J.] Montana State Univ, Dept Microbiol, Bozeman, MT 59717 USA. [Baer, David G.] USA, Inst Surg Res, San Antonio, TX USA. [Hamblin, Michael R.] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA. RP Hamblin, MR (reprint author), Massachusetts Gen Hosp, Wellman Ctr Photomed, BAR414,40 Blossom St, Boston, MA 02114 USA. EM hamblin@helix.mgh.harvard.edu RI Tegos, George/C-8830-2011; OI Hamblin, Michael/0000-0001-6431-4605 FU U.S. Air Force MFEL program [FA9550-04-1-0079]; NIH [AI050875]; Bullock-Wellman Postdoctoral Fellowship Award FX This work was supported by the U.S. Air Force MFEL program ( contract FA9550-04-1-0079) and the NIH ( grant AI050875). T. Dai was supported by a Bullock-Wellman Postdoctoral Fellowship Award. NR 28 TC 64 Z9 68 U1 0 U2 14 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD SEP PY 2009 VL 53 IS 9 BP 3929 EP 3934 DI 10.1128/AAC.00027-09 PG 6 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 496XR UT WOS:000270014200042 PM 19564369 ER PT J AU Aman, MJ Kinch, MS Warfield, K Warren, T Yunus, A Enterlein, S Stavale, E Wang, PF Chang, SJ Tang, QS Porter, K Goldblatt, M Bavari, S AF Aman, M. Javad Kinch, Michael S. Warfield, Kelly Warren, Travis Yunus, Abdul Enterlein, Sven Stavale, Eric Wang, Peifang Chang, Shaojing Tang, Qingsong Porter, Kevin Goldblatt, Michael Bavari, Sina TI Development of a broad-spectrum antiviral with activity against Ebola virus SO ANTIVIRAL RESEARCH LA English DT Article DE Ebola virus; Antiviral; Dengue Fever ID VESICULAR STOMATITIS-VIRUS; IMP DEHYDROGENASE; DENGUE VIRUS; PATHOGENESIS; RIBAVIRIN; FEVER; INFECTION; TOXICITY; THERAPY; INVITRO AB We report herein the identification of a small molecule therapeutic, FGI-106, which displays potent and broad-spectrum inhibition of lethal viral hemorrhagic fevers pathogens, including Ebola, Rift Valley and Dengue Fever viruses, in cell-based assays. Using mouse models of Ebola virus, we further demonstrate that FGI-106 can protect animals from an otherwise lethal infection when used either in a prophylactic or therapeutic setting. A single treatment, administered 1 day after infection, is sufficient to protect animals from lethal Ebola virus challenge. Cell-based assays also identified inhibitory activity against divergent virus families, which supports a hypothesis that FGI-106 interferes with a common pathway utilized by different viruses. These findings suggest FGI-106 may provide an opportunity for targeting viral diseases. (C) 2009 Elsevier B.V. All rights reserved. C1 [Kinch, Michael S.; Yunus, Abdul; Chang, Shaojing; Tang, Qingsong; Goldblatt, Michael] Funct Genet Inc, Gaithersburg, MD 20878 USA. [Aman, M. Javad; Warfield, Kelly; Warren, Travis; Bavari, Sina] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Enterlein, Sven; Stavale, Eric] Integrated BioTherapeut, Germantown, MD 20876 USA. [Wang, Peifang; Porter, Kevin] USN, Med Res Ctr, Silver Spring, MD 20910 USA. RP Kinch, MS (reprint author), Funct Genet Inc, 708 Quince Orchard Rd, Gaithersburg, MD 20878 USA. EM mkinch@functional-genetics.com RI Porter, Kevin/A-8027-2011; OI Kinch, Michael/0000-0003-3939-3756 FU Defense Threat Reduction Agency (DTRA) FX This work was supported by the Transformation Medical Technologies Initiative (TMTI) program of the Defense Threat Reduction Agency (DTRA). NR 22 TC 53 Z9 57 U1 4 U2 28 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD SEP PY 2009 VL 83 IS 3 BP 245 EP 251 DI 10.1016/j.antiviral.2009.06.001 PG 7 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA 489XK UT WOS:000269459300005 PM 19523489 ER PT J AU Brunye, TT Taylor, HA AF Brunye, Tad T. Taylor, Holly A. TI When Goals Constrain: Eye Movements and Memory for Goal-Oriented Map Study SO APPLIED COGNITIVE PSYCHOLOGY LA English DT Article ID SPATIAL MENTAL MODEL; WORKING-MEMORY; VERBAL DESCRIPTIONS; ROUTE DESCRIPTIONS; VISUAL EXPERIENCE; INFORMATION; SPECIFICITY; PERSPECTIVE; IMPACT; REPRESENTATIONS AB Perspective goals, such as studying a map to learn a route through an environment or the overall layout of an environment, produce memory congruent with the goal-directed rather than the studied perspective. One explanation for this finding is that perspective goals guide attention towards actively gathering relevant information during learning. A second explanation is that information is automatically organized into a goal-congruent spatial model that guides retrieval. Both explanations predict goal-congruent memory, but only the former one predicts eye movement differences during study. The present experiment investigated the effect of perspective goals on eye movement during map study and the flexibility of resulting spatial memories. Results demonstrate eye movements towards goal-congruent map elements during learning, and lasting memory effects at test. These findings carry implications for the design of adaptive hand-held and in-vehicle navigation interfaces that accommodate for varied user goals. Copyright (c) 2008 John Wiley & Sons, Ltd. C1 [Brunye, Tad T.] USA, NSRDEC, Attn AMSRD NSC WS P, Natick, MA 01760 USA. [Brunye, Tad T.; Taylor, Holly A.] Tufts Univ, Medford, MA 02155 USA. RP Brunye, TT (reprint author), USA, NSRDEC, Attn AMSRD NSC WS P, Kansas St, Natick, MA 01760 USA. EM tbrunye@alumni.tufts.edu NR 64 TC 19 Z9 19 U1 2 U2 10 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0888-4080 J9 APPL COGNITIVE PSYCH JI Appl. Cogn. Psychol. PD SEP PY 2009 VL 23 IS 6 BP 772 EP 787 DI 10.1002/acp.1508 PG 16 WC Psychology, Experimental SC Psychology GA 483MR UT WOS:000268971400003 ER PT J AU David, NV Gao, XL Zheng, JQ AF David, N. V. Gao, X. -L. Zheng, J. Q. TI Ballistic Resistant Body Armor: Contemporary and Prospective Materials and Related Protection Mechanisms SO APPLIED MECHANICS REVIEWS LA English DT Review DE armour; ballistics; ecocomposites; military equipment; protective clothing ID NATURAL FIBER COMPOSITES; FULLERENE-LIKE STRUCTURES; WOVEN FABRIC COMPOSITES; CARBON NANOTUBES; IMPACT BEHAVIOR; POLYPROPYLENE COMPOSITES; COLLOIDAL SUSPENSIONS; REINFORCED COMPOSITES; INORGANIC NANOTUBES; RAMAN-SPECTROSCOPY AB Modern military operations, technology-driven war tactics, and current on-street weapons and ammunition necessitate the development of advanced ballistic protection body armor systems that are damage-resistant, flexible, lightweight, and of great energy absorbing capacity. A number of studies related to new concepts and designs of body armor materials (including those derived from or inspired by nature) have been conducted in the past two decades to meet the new demands. Ballistic fabrics, ceramics, and laminated composites are among the leading materials used in modern body armor designs, and nano-particle and natural fiber filled composites are candidate materials for new-generation body armor systems. Properties and ballistic resistance mechanisms of such materials have been extensively investigated. Based on a comprehensive and critical review of the advances and findings resulting from these investigations, a comparative study on design, protection mechanisms, and performance evaluation of various types of anti-ballistic body armor is presented in this paper. Body armor systems made from different materials and exhibiting distinct ballistic energy absorption mechanisms are discussed, and key factors that influence the ballistic performance and energy absorbing mechanisms of the body armor systems are identified. C1 [David, N. V.; Gao, X. -L.] Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. [Zheng, J. Q.] USA, Program Execut Off Soldier, Haymarket, VA 20169 USA. RP Gao, XL (reprint author), Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. EM xlgao@tamu.edu RI N.V., David/B-1987-2010 OI N.V., David/0000-0003-4128-5850 FU U.S. Army Soldier Equipment Program FX The work reported here is partially funded by the U.S. Army Soldier Equipment Program. This support is gratefully acknowledged. The authors also wish to thank Prof. Victor Birman and two anonymous reviewers for their encouragement and helpful comments on an earlier version of the paper. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the U.S. Army. NR 146 TC 26 Z9 26 U1 18 U2 133 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0003-6900 J9 APPL MECH REV JI Appl. Mech. Rev. PD SEP PY 2009 VL 62 IS 5 AR 050802 DI 10.1115/1.3124644 PG 20 WC Mechanics SC Mechanics GA 468PC UT WOS:000267830500002 ER PT J AU Marx, BP Brailey, K Proctor, SP MacDonald, HZ Graefe, AC Amoroso, P Heeren, T Vasterling, JJ AF Marx, Brian P. Brailey, Kevin Proctor, Susan P. MacDonald, Helen Z. Graefe, Anna C. Amoroso, Paul Heeren, Timothy Vasterling, Jennifer J. TI Association of Time Since Deployment, Combat Intensity, and Posttraumatic Stress Symptoms With Neuropsychological Outcomes Following Iraq War Deployment SO ARCHIVES OF GENERAL PSYCHIATRY LA English DT Article ID MENTAL-HEALTH PROBLEMS; GULF-WAR; PTSD SYMPTOMS; NEUTRAL INFORMATION; VIETNAM VETERANS; TRAUMA SURVIVORS; MILITARY SERVICE; PHYSICAL HEALTH; US SOLDIERS; DISORDER AB Context: Previous research has demonstrated neuropsychological changes following Iraq deployment. It is unknown whether these changes endure without subsequent war-zone exposure or chronic stress symptoms. Objective: To determine the associations of time since deployment, combat intensity, and posttraumatic stress disorder (PTSD) and depression symptoms with longer-term neuropsychological outcomes in war-deployed soldiers. Design: Prospective cohort study involving (1) soldiers assessed at baseline (median, 42 days prior to deployment) and following return from Iraq (median, 404 days after return and 885 days since baseline), and (2) soldiers more recently returned from deployment assessed at baseline (median, 378 days prior to deployment) and following return from Iraq (median, 122 days after return and 854 days since baseline assessment). Setting: Active-duty military installations. Participants: Two hundred sixty-eight male and female regular active-duty soldiers (164 with 1-year follow-up; 104 recently returned). Main Outcome Measures: Neuropsychological performances (verbal learning, visual memory, attention, and reaction time). Results: There was a significant interaction between time and PTSD symptom severity (B=-0.01 [unstandardized], P=.04). Greater PTSD symptoms were associated with poorer attention in soldiers tested at 1-year follow-up (B=0.01, P=.03) but not in recently returned soldiers. At 1-year follow-up, mean adjusted attention error scores increased by 0.10 points for every 10 points on the PTSD scale. Greater combat intensity was associated with more efficient postdeployment reactiontime performances, regardless of time since deployment (B=0.48, P=.004), with mean adjusted reaction efficiency scores increasing by 4.8 points for every 10 points on the combat experiences scale. Neither depression nor contextual variables (alcohol use and deployment head injury) were significantly related to neuropsychological outcomes. Conclusions: In this study of army soldiers deployed to the Iraq war, only PTSD symptoms (among soldiers back from deployment for 1 year) were associated with a neuropsychological deficit (reduced attention). Greater combat intensity was associated with enhanced reaction time, irrespective of time since return. C1 [Marx, Brian P.; Brailey, Kevin; MacDonald, Helen Z.; Graefe, Anna C.; Vasterling, Jennifer J.] Vet Affairs Natl Ctr PTSD, Behav Sci Div, Boston, MA USA. [Marx, Brian P.; Brailey, Kevin; MacDonald, Helen Z.; Vasterling, Jennifer J.] Vet Affairs Boston Healthcare Syst, Psychol Serv, Boston, MA USA. [Proctor, Susan P.] Vet Affairs Boston Healthcare Syst, Res Serv, Boston, MA USA. [Marx, Brian P.; Brailey, Kevin; MacDonald, Helen Z.; Vasterling, Jennifer J.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA. [Proctor, Susan P.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02118 USA. [Heeren, Timothy] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA. [Proctor, Susan P.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Amoroso, Paul] Madigan Army Med Ctr, Ft Lewis, WA USA. RP Vasterling, JJ (reprint author), VA Boston Healthcare Syst, Psychol Serv 116B, 150 S Huntington Ave, Boston, MA 02130 USA. EM jvaster@bu.edu FU US Army Medical Research and Materiel Command [17-03-0020, A-11815]; Veterans Affairs Clinical Sciences Research and Development awards; South Central Mental Illness Research Education, and Clinical Cente; US Army Research Institute for Environmental Medicine FX This work was supported by US Army Medical Research and Materiel Command (DAMD 17-03-0020; HSRRB Log No. A-11815) and Veterans Affairs Clinical Sciences Research and Development awards. This work was also supported in part by resources provided by the South Central Mental Illness Research, Education, and Clinical Center and US Army Research Institute for Environmental Medicine. Some of the work was completed at the Southeast Louisiana Veterans Healthcare System and Tulane University. The US Army Medical Research Acquisition Activity, Fort Detrick, Maryland, is the awarding and administering acquisition office for DAMD 17-03-0020. NR 61 TC 55 Z9 55 U1 4 U2 8 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0003-990X J9 ARCH GEN PSYCHIAT JI Arch. Gen. Psychiatry PD SEP PY 2009 VL 66 IS 9 BP 996 EP 1004 PG 9 WC Psychiatry SC Psychiatry GA 491PI UT WOS:000269590900009 PM 19736356 ER PT J AU Reed, J Mans, CK Brietzke, SE AF Reed, Jeremy Mans, Carolyn K. Brietzke, Scott E. TI Surgical Management of Drooling - A Meta-analysis SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Article ID SUBMANDIBULAR DUCT RELOCATION; CEREBRAL-PALSY; PAROTID DUCT; FOLLOW-UP; PEDIATRIC POPULATION; 10-YEAR EXPERIENCE; MANDIBULAR GLAND; 4-DUCT LIGATION; SIALORRHEA; CHILDREN AB Objective: To review and assess the current published literature regarding the efficacy of surgical management of sialorrhea in pediatric patients. Data Sources: The MEDLINE database was systematically reviewed for articles reporting on the use of surgical procedures to treat sialorrhea published from January 1, 1963, to November 30, 2008. Study Selection: Inclusion criteria included presence of data on the success of surgical treatment of sialorrhea, English language, sample size greater than 5, and presentation of extractable data regarding the subjective success of surgical management of sialorrhea. Data Extraction: Data regarding demographic characteristics of study participants, follow-up duration, subjective success rates, and number and type of complications were extracted by blinded reviewers. Data Synthesis: A total of 325 studies were identified on initial search. Abstract review reduced the sample to 46. Cross-referencing yielded an additional 4 articles, resulting in the final sample of 50 articles. Forty-seven studies were case series (Centre for Evidence-Based Medicine level 4 evidence), 2 were cohort studies (level 2), and 1 was a prospective cohort study (level 1b). Median sample size was 18 (range, 5-181), and median follow-up duration was 8.1 months (range, 0.1-50 months). Subjective success was reported in more than 50% of patients in 49 of 50 studies. Random-effects modeling estimated the overall subjective success rate for all procedures to be 81.6% (95% confidence interval, 77.5%-85.7%; P<.001). Bilateral submandibular gland excision and parotid duct rerouting appeared to have the highest subjective success rates at 87.8% (k=8 studies; 95% confidence interval, 80.5%-95.1%; P<.001), and 4-duct ligation was the lowest at 64.1% (4 studies; 27.6%-100%; P=.001). Conclusions: Most evidence regarding surgical outcomes of sialorrhea management is low quality and heterogeneous. Despite this, most patients experience a subjective improvement following surgical treatment. C1 [Reed, Jeremy; Mans, Carolyn K.; Brietzke, Scott E.] Walter Reed Army Med Ctr, Dept Otolaryngol, Washington, DC 20307 USA. RP Brietzke, SE (reprint author), Walter Reed Army Med Ctr, Dept Otolaryngol, 6900 Georgia Ave, Washington, DC 20307 USA. EM sebrietzke@msn.com NR 53 TC 29 Z9 29 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0886-4470 J9 ARCH OTOLARYNGOL JI Arch. Otolaryngol. Head Neck Surg. PD SEP PY 2009 VL 135 IS 9 BP 924 EP 931 PG 8 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 494GB UT WOS:000269798700012 PM 19770427 ER PT J AU Spoerke, N Zink, K Cho, SD Differding, J Muller, P Karahan, A Sondeen, J Holcomb, JB Schreiber, M AF Spoerke, Nicholas Zink, Karen Cho, S. David Differding, Jerome Muller, Patrick Karahan, Ayhan Sondeen, Jill Holcomb, John B. Schreiber, Martin TI Lyophilized Plasma for Resuscitation in a Swine Model of Severe Injury SO ARCHIVES OF SURGERY LA English DT Article ID FRESH-FROZEN PLASMA; RED-BLOOD-CELL; MASSIVE TRANSFUSION; ORGAN FAILURE; THERAPEUTIC PLASMA; TRAUMA-REGISTRY; MAJOR TRAUMA; MORTALITY; ILL; EVOLUTION AB Hypothesis: Lyophilized plasma (LP) is as safe and effective as fresh frozen plasma (FFP) for resuscitation after severe trauma. Design: Multicenter animal study. Setting: Animal laboratories, 2 level I trauma centers. Participants: Thirty-two Yorkshire crossbred swine. Interventions: Lyophilized plasma was analyzed for factor levels and clotting activity before lyophilization and after reconstitution. Swine were subjected to complex multiple trauma including extremity fracture, hemorrhage, severe liver injury, acidosis, and hypothermia. They were then resuscitated with FFP, LP, FFP and packed red blood cells (PRBCs) in a ratio of 1:1, or 1:1 LP and PRBCs. Main Outcome Measures: Residual clotting activity of LP after reconstitution, swine mortality, hemodynamic measures, total blood loss, coagulation profiles, and inflammatory measures. Results: Lyophilization decreased clotting factor activity by an average of 1.4%. Survival and heart rate were similar between all groups. Swine resuscitated with LP had equivalent or higher mean arterial pressures. Swine treated with LP had similar coagulation profiles, plasma lactate levels, and postinjury blood loss compared with those treated with FFP. Swine treated with 1:1. FFP-PRBCs were similar to those treated with 1:1 LP-PRBCs. Resuscitation with LP resulted in a reduction in postresuscitation interleukin 6 expression compared with resuscitation with FFP. Conclusions: The process of lyophilization and reconstitution of plasma reduces coagulation factor activity by 14%, without acute differences in blood loss. Lyophilized plasma can be used for resuscitation in a severe multiple trauma and hemorrhagic shock swine model with efficacy equal to that of FFP and with decreased interleukin 6 production. C1 [Spoerke, Nicholas; Zink, Karen; Cho, S. David; Differding, Jerome; Muller, Patrick; Karahan, Ayhan; Schreiber, Martin] Oregon Hlth & Sci Univ, Div Trauma & Crit Care, Portland, OR 97239 USA. [Sondeen, Jill] USA, Inst Surg Res, Off Director Combat Casualty Care Res, San Antonio, TX USA. [Holcomb, John B.] Univ Texas Houston, Div Acute Care Surg, Houston, TX USA. RP Spoerke, N (reprint author), Oregon Hlth & Sci Univ, Div Trauma & Crit Care, 3181 SW Sam Jackson Pk Rd,Mail Code L223A, Portland, OR 97239 USA. EM spoerken@ohsu.edu FU US Army Medical Research Acquisition Activity Award [W81XWH-04-1-0104] FX This study was supported by the US Army Medical Research Acquisition Activity Award No. W81XWH-04-1-0104. NR 31 TC 37 Z9 38 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0004-0010 J9 ARCH SURG-CHICAGO JI Arch. Surg. PD SEP PY 2009 VL 144 IS 9 BP 829 EP 834 PG 6 WC Surgery SC Surgery GA 494RQ UT WOS:000269833500006 PM 19797107 ER PT J AU Nevin, RL Means, GE AF Nevin, Remington L. Means, Gary E. TI Pain and Discomfort in Deployed Helicopter Aviators Wearing Body Armor SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE helicopter; Afghanistan; low back pain; groin pain; sportsman's hernia ID BACK-PAIN; IN-FLIGHT; PILOTS; VIBRATION; AIRCRAFT; FATIGUE AB NEVIN RL, MEANS GE. Pain and discomfort in deployed helicopter aviators wearing body armor. Aviat Space Environ Med 2009; 80:807-10. Background: In early 2007, U.S. Army helicopter aviators deployed to Afghanistan complained of increased pain frequency during flight. The aviators attributed this pain to body armor, which had not been worn prior to deployment. This study was conducted to investigate these complaints. Methods: A retrospective study Of pain frequency among 68 deployed helicopter aviators was performed using self-reported categorical pain ratings and flight times abstracted from a safety questionnaire. TO assess the association of substantial increases in flight time oil reported pain frequency, study subjects were divided into a group reporting a decrease or increase of I In or less in average daily flight hours during deployment as compared to predeployment (level flight hours, LFH) and a group reporting an increase of greater than I h in average daily flight hours (increased flight hours, IFH). Results: A significantly higher proportion of aviators in the IFH group reported an increase in pain frequency as compared to LFH (81.5%, vs. 61.1%, respectively). The relative risk (RR) of increased pain frequency associated with IFH was greatest in the lower back (RR = 1.80), legs (RR = 2.60), arms (RR = 9.11), and the groin (RR = 12.1). Discussion: This study provides preliminary evidence that complaints of increased pain frequency during deployment were associated with substantial increases in flight times. Further Study is warranted to investigate and confirm the underlying causes of this pain. C1 [Nevin, Remington L.] US Africa Command, Combined Joint Task Force Horn Africa, Camp Lemonier, Djibouti. [Means, Gary E.] 82nd Combat Aviat Brigade, Airborne Div 82, Ft Bragg, NC USA. RP Nevin, RL (reprint author), PSC 831,360th CA BDE A, FPO, AE 09363 USA. EM remington.nevin@us.army.mil OI Nevin, Remington/0000-0002-0534-1889 NR 12 TC 12 Z9 12 U1 1 U2 5 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD SEP PY 2009 VL 80 IS 9 BP 807 EP 810 DI 10.3357/ASEM.2236.2009 PG 4 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 488FD UT WOS:000269333700006 PM 19750878 ER PT J AU Crowley, JS Brozoski, FT Duma, SM Kennedy, EA AF Crowley, John S. Brozoski, Frederick T. Duma, Stefan M. Kennedy, Eric A. TI Development of the Facial and Ocular Countermeasures Safety (FOCUS) Headform SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Editorial Material ID EYE C1 [Crowley, John S.; Brozoski, Frederick T.] USA, Aeromed Res Lab, Ft Rucker, AL USA. [Duma, Stefan M.] Virginia Tech, Wake Forest Ctr Injury Biomech, Blacksburg, VA USA. [Kennedy, Eric A.] Bucknell Univ, Lewisburg, PA 17837 USA. RP Crowley, JS (reprint author), USA, Aeromed Res Lab, Ft Rucker, AL USA. RI Duma, Stefan/A-8368-2012 NR 3 TC 4 Z9 4 U1 0 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD SEP PY 2009 VL 80 IS 9 BP 831 EP 831 DI 10.3357/ASEM.21007.2009 PG 1 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 488FD UT WOS:000269333700013 PM 19750883 ER PT J AU Franz, DR Ehrlich, SA Casadevall, A Imperiale, MJ Keim, PS AF Franz, David R. Ehrlich, Susan A. Casadevall, Arturo Imperiale, Michael J. Keim, Paul S. TI THE "NUCLEARIZATION'' OF BIOLOGY IS A THREAT TO HEALTH AND SECURITY SO BIOSECURITY AND BIOTERRORISM-BIODEFENSE STRATEGY PRACTICE AND SCIENCE LA English DT Editorial Material C1 [Franz, David R.] USA, Med Res Inst Infect Dis, Frederick, MD USA. [Ehrlich, Susan A.] Arizona Court Appeals, Phoenix, AZ USA. [Casadevall, Arturo] Yeshiva Univ, Albert Einstein Coll Med, Div Infect Dis, Bronx, NY USA. [Imperiale, Michael J.] Univ Michigan, Sch Med, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA. [Keim, Paul S.] No Arizona Univ, Dept Biol, Flagstaff, AZ 86011 USA. [Keim, Paul S.] Translat Genom Res Inst, Pathogen Genom Div, Flagstaff, AZ USA. RI Keim, Paul/A-2269-2010 FU NIAID NIH HHS [U54 AI057158] NR 0 TC 4 Z9 5 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1538-7135 J9 BIOSECUR BIOTERROR JI Biosecur. Bioterror. PD SEP PY 2009 VL 7 IS 3 BP 243 EP 244 DI 10.1089/bsp.2009.0047 PG 2 WC Public, Environmental & Occupational Health; International Relations SC Public, Environmental & Occupational Health; International Relations GA 505SX UT WOS:000270717200006 PM 19821746 ER PT J AU Eveleigh, DE Mandels, M Andreotti, R Roche, C AF Eveleigh, Douglas E. Mandels, Mary Andreotti, Raymond Roche, Charles TI Measurement of saccharifying cellulase SO BIOTECHNOLOGY FOR BIOFUELS LA English DT Article AB This article sets forth a simple cellulase assay procedure. Cellulose is variable in nature, insoluble and resistant to enzymatic attack. As a result there have been a bevy of bewildering cellulase assays published that yielded irrational results. Certain protocols focused on the rapidity of the assay while ignoring that only the most readily susceptible cellulose regions were being hydrolyzed. Other assays simplified the system by using modified soluble substrates and yielded results that bore no relationship to the real world hydrolysis of insoluble cellulose. In this study Mandels, Andreotti and Roche utilized a common substrate, Whatman filter paper. Hydrolysis of a 50 mg sample of the paper was followed to roughly 4% degradation, which circumvented the problems of attack of only the most susceptible zones. This common hydrolysis target range also resulted in some balance with regard to the interaction of the several cellulase components. The method was subsequently widely adopted. Douglas E Eveleigh C1 [Eveleigh, Douglas E.; Mandels, Mary; Andreotti, Raymond; Roche, Charles] USA, Natick Dev Ctr, Natick, MA 01760 USA. RP Eveleigh, DE (reprint author), USA, Natick Dev Ctr, Natick, MA 01760 USA. EM eveleigh@AESOP.rutgers.edu; not@valid.com; not@valid.com; not@valid.com NR 15 TC 31 Z9 37 U1 5 U2 21 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1754-6834 J9 BIOTECHNOL BIOFUELS JI Biotechnol. Biofuels PD SEP 1 PY 2009 VL 2 AR 21 DI 10.1186/1754-6834-2-21 PG 8 WC Biotechnology & Applied Microbiology; Energy & Fuels SC Biotechnology & Applied Microbiology; Energy & Fuels GA 523SP UT WOS:000272095100002 PM 19723298 ER PT J AU Larpov, KA Kogut, NJ Geibel, JJ AF Larpov, Konstantin A. Kogut, Nina J. Geibel, John J. TI ESTIMATING FISH LENGTH FROM VERTICAL MORPHOMETRIC PARAMETERS SO CALIFORNIA FISH AND GAME LA English DT Article ID STEREO-VIDEO SYSTEM; REEF-FISH; PRECISION; ACCURACY; CONVERSIONS; CALIFORNIA; ALLOMETRY; HABITAT; MARINE; SHARKS AB Fish lengths are important for resource assessment and management, particularly when methods to obtain age or weight are impractical or harmful to the resource. Underwater videos are commonly used to monitor fisheries because they are less invasive than other sampling methods. However, because of a fish's continuous lateral flexion while swimming and angle to the viewer, its length is often difficult to estimate from videos. In many cases, vertical morphometric parameters may be measured more accurately than horizontal parameters. To evaluate vertical parameters as predictors of length, regression equations were developed for species observed in underwater videos along the California coast, including kelp greenling, Hexagrammos decagrammus, lingcod, Ophiodon elongatus, black rockfish, Sebastes melanops, and blue rockfish, S. mystinus. A separate regression was calculated for combined rockfish, Sebastes spp., to serve as a monitoring tool until sufficient samples are collected for more specific regressions. Species combined were gopher rockfish, S. carnatus, copper rockfish, S. caurinus, black and yellow rockfish, S. chrysomelas, yellowtail rockfish, S. flavidus, quillback rockfish, S. maliger, black rockfish, S. melanops, vermilion rockfish, S. miniatus, blue rockfish, S. mystinus, China rockfish, S. nebulosus, canary rockfish, S. pinniger, and olive rockfish, S. serranoides. Vertical parameters were depth at mid-orbit, depth at pelvic fin origin, depth at anal fin origin, and least depth at caudal peduncle. Relationships between each vertical parameter and fork length were strongly correlated for individual species (r >= 0.973) and combined rockfish species (r >= 0.947). C1 [Larpov, Konstantin A.] Calif Dept Fish & Game, Ft Bragg, CA 95437 USA. [Kogut, Nina J.] Calif Dept Fish & Game, Monterey, CA 93940 USA. [Geibel, John J.] Calif Dept Fish & Game, Belmont, CA 94002 USA. EM nkogut@dfg.ca.gov NR 39 TC 0 Z9 0 U1 0 U2 4 PU CALIFORNIA FISH AND GAME EDITOR PI SACRAMENTO PA 1416 NINTH ST, SACRAMENTO, CA 95814 USA SN 0008-1078 J9 CALIF FISH GAME JI Calif. Fish Game PD FAL PY 2009 VL 95 IS 4 BP 161 EP 174 PG 14 WC Fisheries; Zoology SC Fisheries; Zoology GA 612YS UT WOS:000278942600003 ER PT J AU Alper, O Stetler-Stevenson, WG Harris, LN Leitner, WW Ozdemirli, M Hartmann, D Raffeld, M Abu-Asab, M Byers, S Zhuang, Z Oldfield, EH Tong, Y Bergmann-Leitner, E Criss, WE Nagasaki, K Mol, SC Cramer, DW Karaveli, FS Goldbach-Mansky, R Leo, P Stromberg, K Weil, RJ AF Alper, Oezge Stetler-Stevenson, William G. Harris, Lyndsay N. Leitner, Wolfgang W. Ozdemirli, Metin Hartmann, Dan Raffeld, Mark Abu-Asab, Mones Byers, Stephen Zhuang, Zhengping Oldfield, Edward H. Tong, Yanhe Bergmann-Leitner, Elke Criss, Wayne E. Nagasaki, Koichi Mol, Samuel C. Cramer, Daniel W. Karaveli, F. Seyda Goldbach-Mansky, Raphaela Leo, Paul Stromberg, Kurt Weil, Robert J. TI Novel anti-filamin-A antibody detects a secreted variant of filamin-A in plasma from patients with breast carcinoma and high-grade astrocytoma SO CANCER SCIENCE LA English DT Article ID CATHEPSIN-B; SERUM HER-2/NEU; CANCER CELLS; EXPRESSION; BINDING; TRAFFICKING; ABP-280 AB Identification of tumor-derived proteins in the circulation may allow for early detection of cancer and evaluation of therapeutic responses. To identify circulating tumor-derived proteins, mice were immunized with concentrated culture medium conditioned by human breast cancer cells. Antibodies generated by hybridomas were screened against conditioned media from both normal epithelial cells and tumor cells. Antibody selectively reacting with tumor cell-conditioned media was further characterized. This led to the development of a monoclonal antibody (Alper-p280) that reacts with a newly identified 280-kDa secreted variant of human filamin-A. Circulating filamin-A was detected in patient plasma samples using Alper-p280 in an ELISA assay. Human plasma samples from 134 patients with brain, breast, or ovarian cancer, 15 patients with active arthritis, and 76 healthy controls were analyzed. Filamin-A protein levels in human cell lines and tissues were analyzed by western blotting, immunohistochemistry, and electron and confocal microscopy. Circulating filamin-A was detected in the plasma of 109 of 143 patients with breast cancer and primary brain tumors. Plasma levels of filamin-A showed 89.5% sensitivity (95% confidence interval [CI] = 0.67% to 0.99%) and 97.8% specificity (95% CI = 0.88% to 0.99%) for glioblastoma at a cut-off of 21.0 ng/mL. Plasma levels of filamin-A (> 36.0 ng/mL) had 96.7% sensitivity (95% CI = 0.80% to 0.99%) and 67.8% specificity (95% CI = 0.54% to 0.79%) for metastatic breast cancer. Filamin-A levels were increased in malignant breast or brain tissues, but not in normal control tissues. Filamin-A localized to lysosomes in MDA.MB.231 breast cancer cells, but not in normal human mammary epithelial cells, suggesting that filamin-A may undergo cancer-specific processing. Plasma filamin-A appears to be a specific and sensitive marker for patients with high-grade astrocytoma or metastatic breast cancer. Additional novel cancer biomarkers have been identified and are being developed alongside Alper-p280 for use in diagnosis of breast carcinoma and high-grade astrocytoma, and for use in the evaluation of therapeutic responses. (Cancer Sci 2009; 100: 1748-1756). C1 [Alper, Oezge] Alper Biotech LLC, Rockville, MD USA. [Stetler-Stevenson, William G.] NCI, Cell & Canc Biol Branch, Bethesda, MD 20892 USA. [Harris, Lyndsay N.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. [Leitner, Wolfgang W.] NCI, Dermatol Branch, Bethesda, MD 20892 USA. [Ozdemirli, Metin; Hartmann, Dan] Georgetown Univ, Med Ctr, Lombardi Canc Ctr, Dept Pathol, Washington, DC 20007 USA. [Raffeld, Mark; Abu-Asab, Mones] NCI, Pathol Branch, Bethesda, MD 20892 USA. [Byers, Stephen] Georgetown Univ, Med Ctr, Lombardi Canc Ctr, Dept Oncol, Washington, DC 20007 USA. [Zhuang, Zhengping; Oldfield, Edward H.] Natl Inst Neurol Disorders & Stroke, Bethesda, MD USA. [Tong, Yanhe] VaxGen Inc, San Francisco, CA USA. [Bergmann-Leitner, Elke] Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD USA. [Criss, Wayne E.] Hacettepe Univ, Dept Biochem, Ankara, Turkey. [Nagasaki, Koichi] Natl Genome Res Ctr, Tokyo, Japan. [Mol, Samuel C.; Cramer, Daniel W.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA. [Karaveli, F. Seyda] Akdeniz Univ, Sch Med, Dept Pathol, TR-07058 Antalya, Turkey. [Goldbach-Mansky, Raphaela] NIAMSD, NIH, Bethesda, MD 20892 USA. [Leo, Paul] NIH, Human Genome Res Ctr, Bethesda, MD 20892 USA. [Stromberg, Kurt] US FDA, Div Therapeut Prot, Bethesda, MD 20014 USA. [Weil, Robert J.] Cleveland Clin Fdn, Neurol Inst, Dept Neurosurg, Brain Tumor & Neurooncol Ctr, Cleveland, OH 44195 USA. RP Alper, O (reprint author), Alper Biotech LLC, Rockville, MD USA. EM oalper@alperbiotech.com RI Bergmann-Leitner, Elke/B-3548-2011; Leitner, Wolfgang/F-5741-2011; Stetler-Stevenson, William/H-6956-2012; Leo, Paul/B-3470-2011; KARAVELI, FATMA SEYDA/C-6335-2016; OI Bergmann-Leitner, Elke/0000-0002-8571-8956; Leitner, Wolfgang/0000-0003-3125-5922; Stetler-Stevenson, William/0000-0002-5500-5808; Leo, Paul/0000-0001-8325-4134; Abu-Asab, Mones/0000-0002-4047-1232 FU National Institute Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA FX This research was supported in part by the Intramural Research Program of the National Institute Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA. The authors thank Dianne Hirsch, PhD, for critical reading and editing of the manuscript. The authors thank Ken Yamaguchi, MD, for scientific discussions and support during the early stages of project development. NR 27 TC 25 Z9 27 U1 1 U2 6 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1347-9032 J9 CANCER SCI JI Cancer Sci. PD SEP PY 2009 VL 100 IS 9 BP 1748 EP 1756 DI 10.1111/j.1349-7006.2009.01244.x PG 9 WC Oncology SC Oncology GA 482XL UT WOS:000268923800028 PM 19594548 ER PT J AU Platt, SG Brantley, CG Rainwater, TR AF Platt, Steven G. Brantley, Christopher G. Rainwater, Thomas R. TI Native American Ethnobotany of Cane (Arundinaria spp.) in the Southeastern United States: A Review SO CASTANEA LA English DT Article; Proceedings Paper CT Symposium on Them's the Brakes - The Past and Future of North American Bamboo CY APR 17, 2008 CL Spartanburg, SC SP Furman Univ, Wofford Coll, Assoc SE Biologists, So Appalachian Bot Soc ID BAMBOO; GIGANTEA; ACCOUNT AB Cane (Arundinaria spp.) was one of the most important plant resources for Native Americans living in the southeastern United States prior to Euro-American settlement. The use of cane permeated virtually every aspect of tribal life. Cane was used to make houses and village structures, military and hunting weapons, fishing gear, furniture and domestic implements, personal adornments, baskets, musical instruments, and watercraft. Medicines were prepared from cane, and parts of the plant furnished food and fuel. Canebrakes provided agricultural land, livestock forage, and habitat for wild game. Although large numbers of canes were harvested each year, there is no historic evidence that Native Americans actively managed canebrakes for the production of culms. The cultural importance of cane to Native Americans declined dramatically following Euro-American settlement of the southeast because: 1) trade goods were deemed superior and replaced articles made from cane in local economies; 2) the rapid disappearance of canebrakes deprived Native Americans of raw material and forced them to seek alternatives; and, 3) many of southeastern tribes were eventually relocated to regions peripheral to or outside of the geographic range of cane. C1 [Platt, Steven G.] Sul Ross State Univ, Dept Biol, Alpine, TX 79832 USA. [Brantley, Christopher G.] USA Corps Engineers, Norco, LA 70079 USA. RP Platt, SG (reprint author), Sul Ross State Univ, Dept Biol, Box C-64, Alpine, TX 79832 USA. EM splatt@sulross.edu NR 125 TC 1 Z9 1 U1 1 U2 12 PU SOUTHERN APPALACHIAN BOTANICAL SOC, NEWBERRY COLL PI NEWBERRY PA DEPT BIOLOGY, C/O CHARLES N HORN, SECRETARY-TREASURER, 2100 COLLEGE ST, NEWBERRY, SC 29108 USA SN 0008-7475 EI 1938-4386 J9 CASTANEA JI Castanea PD SEP PY 2009 VL 74 IS 3 BP 271 EP 285 PG 15 WC Plant Sciences SC Plant Sciences GA 508MP UT WOS:000270935800009 ER PT J AU Citino, RM AF Citino, Robert M. TI The Brusilov Offensive SO CENTRAL EUROPEAN HISTORY LA English DT Book Review C1 [Citino, Robert M.] US Mil Acad, West Point, NY 10996 USA. RP Citino, RM (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 0008-9389 J9 CENT EUR HIST JI Cent. Eur. Hist. PD SEP PY 2009 VL 42 IS 3 BP 563 EP 565 DI 10.1017/S0008938909990549 PG 3 WC History SC History GA 494LU UT WOS:000269815500014 ER PT J AU Gambino, SL King, CS Lettieri, CJ AF Gambino, Sharon Lynn King, Christopher S. Lettieri, Christopher J. TI Multiple Pulmonary Nodules in a 70-Year-Old Female With a History of Breast Cancer SO CHEST LA English DT Editorial Material ID IDIOPATHIC DIFFUSE HYPERPLASIA; NEUROENDOCRINE CELLS; CARCINOID TUMORLETS; LYMPH-NODE; LUNG; METASTASIS C1 [Gambino, Sharon Lynn] Walter Reed Army Med Ctr, Dept Internal Med, Washington, DC 20307 USA. [King, Christopher S.; Lettieri, Christopher J.] Walter Reed Army Med Ctr, Dept Pulm & Crit Care Med, Washington, DC 20307 USA. RP Gambino, SL (reprint author), Walter Reed Army Med Ctr, Dept Internal Med, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM sharon.gambino@amedd.army.mil NR 9 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD SEP PY 2009 VL 136 IS 3 BP 938 EP 941 DI 10.1378/chest.08-2994 PG 4 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 493JT UT WOS:000269733400042 PM 19736199 ER PT J AU Zanders, TB Morris, M McNeil, M AF Zanders, Thomas B. Morris, Michael McNeil, Matthew TI Sarcoidosis or Sarcoid Reaction? Response SO CHEST LA English DT Letter ID CANCER; WOMAN C1 [Zanders, Thomas B.; Morris, Michael] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [McNeil, Matthew] William Beaumont Army Med Ctr, El Paso, TX 79920 USA. RP Zanders, TB (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. EM thomas.zanders@amedd.army.mil NR 6 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD SEP PY 2009 VL 136 IS 3 BP 944 EP 944 DI 10.1378/chest.09-1013 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 493JT UT WOS:000269733400045 ER PT J AU Rafuse, ES AF Rafuse, Ethan S. TI Civil War to the Bloody End: The Life and Times of Major General Samuel P. Heintzelman. SO CIVIL WAR HISTORY LA English DT Book Review C1 [Rafuse, Ethan S.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Rafuse, ES (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU KENT STATE UNIV PRESS PI KENT PA C/O JOURNALS DEPT, KENT, OH 44242 USA SN 0009-8078 J9 CIVIL WAR HIST JI Civil War Hist. PD SEP PY 2009 VL 55 IS 3 BP 427 EP 429 PG 3 WC History SC History GA 493TE UT WOS:000269760100032 ER PT J AU Scala, JJ Orlicki, JA Jain, R Ulven, CA Palmese, GR Vaidya, UK Sands, JM AF La Scala, John J. Orlicki, Joshua A. Jain, Rahul Ulven, Chad A. Palmese, Giuseppe R. Vaidya, Uday K. Sands, James M. TI Emission modeling of styrene from vinyl ester resins with low hazardous air pollutant contents SO CLEAN TECHNOLOGIES AND ENVIRONMENTAL POLICY LA English DT Article DE Diffusion; Evaporation; Modeling; Styrene; Vinyl ester ID MONOMERS AB Styrene is a commonly used co-monomer in vinyl ester (VE) resins, which acts as a reactive diluent and is required in most liquid molding fabrication methods to reduce viscosity and improve overall resin performance. Resins containing low hazardous air pollutant contents have been developed to reduce the styrene emissions during composite fabrication. VE monomers with a bimodal molecular weight distribution have been used to effectively decrease the amount of styrene in the system while maintaining low resin viscosities. Fatty acid vinyl ester (FAVE) resins partially replace styrene with non-volatile fatty acid monomers to reduce styrene emissions. The emissions from bimodal and FAVE resins were measured as a function of time and various parameters, including styrene content, VE molecular weight, and fatty acid monomer content and chain length. The initial emission rate from VE resins is only dependent on styrene content for constant evaporation geometry. Furthermore, the evaporation rate constant was the same regardless of VE molecular weight, styrene content, or the use of co-reactive diluent (MFA monomers). The diffusivity was not dependent on the styrene content in the resin, but decreased linearly as the VE molecular weight increased because of a corresponding increase in the resin viscosity. The diffusivity also increased as the content of MFA increased because of a decrease in the resin viscosity with high MFA content at high emission time. Furthermore, the emission profiles were accurately modeled using a modified version of 1D diffusion through a planar sheet that accounts for the depth change as a function of styrene evaporation. Overall, the model predicted emission profiles similar to the experimentally measured profiles as a function of time for various styrene contents, VE molecular weights, and fatty acid monomer contents. C1 [La Scala, John J.; Orlicki, Joshua A.; Sands, James M.] USA, Res Lab, Weap & Mat Res Directorate, AMSRD ARL WM MC, Aberdeen Proving Ground, MD 21005 USA. [Jain, Rahul; Ulven, Chad A.; Vaidya, Uday K.] Univ Alabama Birmingham, Dept Mat Sci & Engn, Birmingham, AL 35294 USA. [Ulven, Chad A.] N Dakota State Univ, Dept Mech Engn, Fargo, ND 58105 USA. [Palmese, Giuseppe R.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. RP Scala, JJ (reprint author), USA, Res Lab, Weap & Mat Res Directorate, AMSRD ARL WM MC, Aberdeen Proving Ground, MD 21005 USA. EM jlascala@arl.army.mil FU Strategic Environmental Research and Development Program (SERDP) [PP-1271]; Environmental Security Technology Certification Program (ESTCP) [WP-0617] FX The authors thank the support for this work provided by Strategic Environmental Research and Development Program (SERDP) project PP-1271 and Environmental Security Technology Certification Program (ESTCP) WP-0617. NR 22 TC 1 Z9 1 U1 0 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1618-954X EI 1618-9558 J9 CLEAN TECHNOL ENVIR JI Clean Technol. Environ. Policy PD SEP PY 2009 VL 11 IS 3 BP 283 EP 292 DI 10.1007/s10098-008-0181-4 PG 10 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental; Environmental Sciences SC Science & Technology - Other Topics; Engineering; Environmental Sciences & Ecology GA 490UB UT WOS:000269530000006 ER PT J AU Hurst, FP Neff, RT Katz, AR Buchholz, AE Sasaki, DM Berg, BW Abbott, KC AF Hurst, F. P. Neff, R. T. Katz, A. R. Buchholz, A. E. Sasaki, D. M. Berg, B. W. Abbott, K. C. TI Acute kidney injury requiring hemodialysis in patients with anicteric leptospirosis SO CLINICAL NEPHROLOGY LA English DT Article DE leptospirosis; acute kidney injury; acute tubulointerstitial nephritis ID ACUTE-RENAL-FAILURE; CONFIRMED LEPTOSPIROSIS; HAWAII AB Background: Leptospirosis is an infrequent disease in the US, with most cases reported in the state of Hawaii. Renal involvement is common (44-67%), ranging from a mild prerenal azotemia in anicteric disease to renal failure requiring dialysis in Weil's syndrome (severe leptospirosis with jaundice, renal failure, and hemorrhage). Methods: To describe the pattern of leptospiral renal disease at our institution, we performed a retrospective analysis (1992-2004) of all hospitalized cases of laboratory confirmed leptospirosis presenting with acute kidney injury (AKI), defined as a presenting serum creatinine > 1.5 mg/dl. Results: During this time period, 18 patients were hospitalized with laboratory confirmed leptospirosis. Among these patients, 12 had AKI on presentation, and hemodialysis was required in 3 patients. Renal biopsies were performed in 2 of these patients, revealing acute tubulointerstitial nephritis. Interestingly, the patients who required dialysis did not have Weil's syndrome. They did not exhibit jaundice or hemorrhage, and serum AST (mean 51.7 U/l (range 36-60)), ALT(mean 51.0 U/l (range 38-64)), and total bilirubin (mean 1.2 mg/dl (range 0.8-1.8)) were either within normal limits or only slightly elevated, despite having the worst renal disease. Conclusions: This series adds to other evidence that severe AKI (requiring dialysis) can complicate anicteric leptospirosis in contrast to the notion that the AKI in anicteric disease is typically mild and prerenal. Leptospirosis should be considered in all patients who present with fever and AKI, especially if associated with thrombocytopenia or travel to an endemic area. C1 [Hurst, F. P.] Walter Reed Army Med Ctr, Dept Nephrol, Serv Nephrol, Washington, DC 20307 USA. [Hurst, F. P.; Neff, R. T.; Abbott, K. C.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. [Hurst, F. P.; Berg, B. W.] Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA. [Katz, A. R.] Univ Hawaii, John A Burns Sch Med, Dept Publ Hlth Sci, Honolulu, HI 96822 USA. [Buchholz, A. E.; Sasaki, D. M.] Univ Hawaii, Hawaii Dept Hlth, Dis Outbreak Control Div, Honolulu, HI 96822 USA. [Berg, B. W.] Univ Hawaii, John A Burns Sch Med, Telehlth Res Inst, Honolulu, HI 96822 USA. RP Hurst, FP (reprint author), Walter Reed Army Med Ctr, Dept Nephrol, Serv Nephrol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM frank.hurst@us.army.mil OI Abbott, Kevin/0000-0003-2111-7112 NR 23 TC 5 Z9 5 U1 0 U2 2 PU DUSTRI-VERLAG DR KARL FEISTLE PI DEISENHOFEN-MUENCHEN PA BAHNHOFSTRASSE 9 POSTFACH 49, D-82032 DEISENHOFEN-MUENCHEN, GERMANY SN 0301-0430 J9 CLIN NEPHROL JI Clin. Nephrol. PD SEP PY 2009 VL 72 IS 3 BP 186 EP 192 PG 7 WC Urology & Nephrology SC Urology & Nephrology GA 511LQ UT WOS:000271167100005 PM 19761723 ER PT J AU Joe, KJ Huitron, SS Crawford, JJ Frink, SJ AF Joe, Keith J. Huitron, Sonny S. Crawford, John J. Frink, Spencer J. TI Idiopathic Equinocavovarus Foot Deformity in an 8-year-old Girl SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article ID OF-THE-LITERATURE; MELORHEOSTOSIS C1 [Joe, Keith J.] Wilford Hall USAF Med Ctr, Dept Orthopaed, Lackland AFB, TX 78236 USA. [Huitron, Sonny S.] Wilford Hall USAF Med Ctr, Dept Pathol, San Antonio, TX 78236 USA. [Crawford, John J.] Brooke Army Med Ctr, Dept Pediat Orthopaed, San Antonio, TX USA. [Frink, Spencer J.] Wilford Hall USAF Med Ctr, Dept Orthopaed Oncol, San Antonio, TX 78236 USA. RP Joe, KJ (reprint author), Wilford Hall USAF Med Ctr, Dept Orthopaed, 2200 Bergquist Dr,Suite 1, Lackland AFB, TX 78236 USA. EM dyno_kjoe@hotmail.com FU Wilford Hall Medical Center Departments of Orthopaedics and Pathology FX We thank the Wilford Hall Medical Center Departments of Orthopaedics and Pathology, and the Brooke Army Medical Center Department of Orthopaedics, for contributions to this article. NR 16 TC 1 Z9 2 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0009-921X J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD SEP PY 2009 VL 467 IS 9 BP 2482 EP 2486 DI 10.1007/s11999-008-0677-6 PG 5 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 476YY UT WOS:000268483900037 PM 19198964 ER PT J AU LaMattina, B Li, GQ Hui, D AF LaMattina, Bruce Li, Guoqiang Hui, David TI Blast/impact on engineered (nano)composite materials SO COMPOSITES PART B-ENGINEERING LA English DT Editorial Material C1 [LaMattina, Bruce] USA, Res Off, Res Triangle Pk, NC 27709 USA. [Li, Guoqiang] Louisiana State Univ, Dept Mech Engn, Baton Rouge, LA 70803 USA. [Hui, David] Univ New Orleans, Dept Mech Engn, New Orleans, LA 70148 USA. RP LaMattina, B (reprint author), USA, Res Off, POB 12211, Res Triangle Pk, NC 27709 USA. EM Bruce.LaMattina@us.army.mil; guoli@me.lsu.edu; dhui@uno.edu NR 0 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-8368 J9 COMPOS PART B-ENG JI Compos. Pt. B-Eng. PD SEP PY 2009 VL 40 IS 6 BP 413 EP 415 DI 10.1016/j.compositesb.2009.05.002 PG 3 WC Engineering, Multidisciplinary; Materials Science, Composites SC Engineering; Materials Science GA 485HK UT WOS:000269111600001 ER PT J AU LaMattina, B AF LaMattina, Bruce TI The US Army Research Office's Solid Mechanics Perspective SO COMPOSITES PART B-ENGINEERING LA English DT Editorial Material C1 USA, Res Off, Res Triangle Pk, NC 27709 USA. RP LaMattina, B (reprint author), USA, Res Off, POB 12211, Res Triangle Pk, NC 27709 USA. EM Bruce.LaMattina@us.army.mil NR 0 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-8368 J9 COMPOS PART B-ENG JI Compos. Pt. B-Eng. PD SEP PY 2009 VL 40 IS 6 BP 416 EP 416 DI 10.1016/j.compositesb.2009.05.004 PG 1 WC Engineering, Multidisciplinary; Materials Science, Composites SC Engineering; Materials Science GA 485HK UT WOS:000269111600002 ER PT J AU Clayton, JD AF Clayton, J. D. TI Modeling effects of crystalline microstructure, energy storage mechanisms, and residual volume changes on penetration resistance of precipitate-hardened aluminum alloys SO COMPOSITES PART B-ENGINEERING LA English DT Article DE Metal-matrix composite; Impact behavior; Plastic deformation; Micro-mechanics ID DYNAMIC PLASTICITY; PLATE IMPACT; DEFORMATION; METALS; POLYCRYSTALS; FRACTURE; TEXTURE; SOLIDS; STRAIN; SPALL AB An anisotropic nonlinear crystal mechanics model is developed for a class of ductile aluminum alloys, with the intent of relating microscopic features and properties to performance of the alloys deformed at high strain rates that may arise during impact and blast events. A direct numerical simulation of dynamic tensile deformation of an aluminum polycrystal demonstrates a tendency for shear localization to occur in regions of the microstructure where the ratio of the rate of residual (i.e., stored) elastic energy to plastic dissipation is minimal. By coarse-graining predictions of the crystal plasticity framework using a Taylor averaging scheme, a macroscopic constitutive model is developed to investigate effects of microstructure on ballistic perforation resistance of plates of an Al-Cu-Mg-Ag alloy. Specific aspects of microstructure investigated include random and rolled cubic textures as well as stored elastic energy and residual volume changes associated with lattice defects, impurities, and inclusions such as second phases in the metal-matrix composite. Results suggest performance could be improved by tailoring microstructures to increase the shear yield strength and the ratio of residual elastic energy to dissipated heat. Published by Elsevier Ltd. C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Clayton, JD (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM jclayton@arl.army.mil RI Clayton, John/C-7760-2009 FU ARL WMRD; JIEDDO FX This work was supported by ARL WMRD and JIEDDO. NR 38 TC 8 Z9 8 U1 2 U2 13 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-8368 EI 1879-1069 J9 COMPOS PART B-ENG JI Compos. Pt. B-Eng. PD SEP PY 2009 VL 40 IS 6 SI SI BP 443 EP 450 DI 10.1016/j.compositesb.2009.01.009 PG 8 WC Engineering, Multidisciplinary; Materials Science, Composites SC Engineering; Materials Science GA 485HK UT WOS:000269111600006 ER PT J AU Dongare, AM Zhigilei, LV Rajendran, AM LaMattina, B AF Dongare, A. M. Zhigilei, L. V. Rajendran, A. M. LaMattina, B. TI Interatomic potentials for atomic scale modeling of metal-matrix ceramic particle reinforced nanocomposites SO COMPOSITES PART B-ENGINEERING LA English DT Article DE Interatomic potentials; Metal-matrix composites (MMCs); Interface/interphase; Computational modelling ID FUNCTIONALLY GRADED METALS; MONTE-CARLO-SIMULATION; MOLECULAR-DYNAMICS; FCC METALS; SILICON; ALLOYS; HYDROCARBONS; COMPOSITES; IMPURITIES; SURFACES AB Functionally graded particle reinforced metal-matrix nanocomposite materials show significant promise for use in protective structures due to their high strengths, stiffness, failure resistance, and the ability to mitigate damage during ballistic impact. Further improvement of the performance of these materials requires fine-tuning of the nanostructure which, in turn, necessitates a clear fundamental understanding of the deformation and failure mechanisms under conditions of dynamic loading. While the molecular dynamics simulation technique is an excellent tool for investigation of the mechanisms of plastic deformation and failure of the particle reinforced metal-matrix nanocomposites at the atomic scale, the predictive power of the technique relies on an accurate description of the interatomic interactions. This paper provides a brief review of a recently developed class of interatomic potentials capable of the computationally efficient description of multi-component systems composed of metals, Si, Ge, and C. The potentials are based on reformulation of the Embedded Atom Method (EAM) potential for metals and two empirical potentials commonly used for covalently bonded materials, Stillinger-Weber (SW) and Tersoff, in a compatible functional form. The description of the angular dependence of interatomic interactions in the covalent materials is incorporated into the framework of the EAM potential and, therefore, the new class of potentials is dubbed Angular-dependent EAM (A-EAM) potentials. The A-EAM potentials retain all the properties of the pure components as predicted by the original SW, Tersoff, and EAM potentials, thus eliminating the need for extensive testing and limiting the scope of the potential parameterization to only the cross-interaction between the components. The performance of the A-EAM potentials is illustrated for the Au-Si system, with good agreement with experimental data obtained for the enthalpy of mixing in the Au-Si liquid alloy and the Au-Si phase diagram. The A-EAM potentials are suitable for large-scale atomistic simulations of metal-Si/Ge/C/SiC systems, such as the ones required for investigation of the dynamic response of nanocomposite materials to a ballistic/blast impact. Published by Elsevier Ltd. C1 [LaMattina, B.] USA, Res Off, Res Triangle Pk, NC 27709 USA. [Dongare, A. M.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Zhigilei, L. V.] Univ Virginia, Dept Mat Sci & Engn, Charlottesville, VA USA. [Rajendran, A. M.] Univ Mississippi, Dept Mech Engn, Olemiss, MS USA. RP LaMattina, B (reprint author), USA, Res Off, Res Triangle Pk, NC 27709 USA. EM Bruce.LaMattina@us.army.mil RI Rajendran, Arunachalam/A-1615-2010; Dongare, Avinash/A-3470-2009; Zhigilei, Leonid/E-2167-2012; OI Dongare, Avinash/0000-0003-3189-3588 FU National Science Foundation [CTS-0348503] FX Financial support of this work was provided by the National Science Foundation through the University of Virginia MRSEC Center for Nanoscopic Materials Design (A.M.D.) and Grant CTS-0348503 (LV.Z.). NR 46 TC 10 Z9 10 U1 3 U2 32 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-8368 J9 COMPOS PART B-ENG JI Compos. Pt. B-Eng. PD SEP PY 2009 VL 40 IS 6 BP 461 EP 467 DI 10.1016/j.compositesb.2009.02.001 PG 7 WC Engineering, Multidisciplinary; Materials Science, Composites SC Engineering; Materials Science GA 485HK UT WOS:000269111600008 ER PT J AU Grujicic, M Arakere, G He, T Bell, WC Glomski, PS Cheeseman, BA AF Grujicic, M. Arakere, G. He, T. Bell, W. C. Glomski, P. S. Cheeseman, B. A. TI Multi-scale ballistic material modeling of cross-plied compliant composites SO COMPOSITES PART B-ENGINEERING LA English DT Article DE Polymer-matrix composites (PMCs); Damage tolerance; Finite element analysis (FEA); Armor-grade composites ID LAMINATED KEVLAR; FORCE-FIELD; IMPACT; PENETRATION; ARMOR; PROJECTILES; MECHANISMS; FAILURE; COMPASS; EPOXY AB The open-literature material properties for fiber and polymeric matrix, unit-cell microstructural characteristics, atomic-level simulations and unit-cell based finite-element analyses are all used to construct a new continuum-type ballistic material model for 0 degrees/90 degrees cross-plied highly-oriented polyethylene fiber-based armor-grade composite laminates. The material model is formulated in such a way that it can be readily implemented into commercial finite-element programs like ANSYS/Autodyn [ANSYS/Autodyn version 11.0, User Documentation, Century Dynamics Inc. a subsidiary of ANSYS Inc. (2007)] and ABAQUS/Explicit [ABAQUS version 6.7, User Documentation, Dessault Systems, 20071 as a User Material Subroutine. Model validation included a series of transient non-linear dynamics simulations of the transverse impact of armor-grade composite laminates with two types of projectiles, which are next compared with their experimental counterparts. This comparison revealed that a reasonably good agreement is obtained between the experimental and the computational analyses with respect to: (a) the composite laminates' capability, at different area] densities, to defeat the bullets with different impact velocities; (b) post-mortem spatial distribution of damage within the laminates; (c) the temporal evolution of composite armor laminate back-face bulging and delamination; and (d) the existence of three distinct penetration stages (i.e. an initial filament shearing/cutting dominated stage, an intermediate stage characterized by pronounced filament/matrix de-bonding/decohesion and the final stage associated with the extensive back-face delamination and bulging of the armor panel). (C) 2009 Elsevier Ltd. All rights reserved. C1 [Grujicic, M.; Arakere, G.; He, T.; Bell, W. C.; Glomski, P. S.] Clemson Univ, Dept Mech Engn, Int Ctr Automot Res CU ICAR, Clemson, SC 29634 USA. [Cheeseman, B. A.] USA, Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, Int Ctr Automot Res CU ICAR, Clemson, SC 29634 USA. EM mica.grujicic@ces.clemson.edu NR 39 TC 28 Z9 28 U1 4 U2 20 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-8368 J9 COMPOS PART B-ENG JI Compos. Pt. B-Eng. PD SEP PY 2009 VL 40 IS 6 BP 468 EP 482 DI 10.1016/j.compositesb.2009.02.002 PG 15 WC Engineering, Multidisciplinary; Materials Science, Composites SC Engineering; Materials Science GA 485HK UT WOS:000269111600009 ER PT J AU Souza, FV Kim, YR Gazonas, GA Allen, DH AF Souza, Flavio V. Kim, Yong-Rak Gazonas, George A. Allen, David H. TI Computational model for predicting nonlinear viscoelastic damage evolution in materials subjected to dynamic loading SO COMPOSITES PART B-ENGINEERING LA English DT Article DE Debonding; Fracture; Computational modelling; Cohesive zone model ID CRACK-PROPAGATION; COHESIVE ZONE; BRITTLE MATERIALS; FRACTURE; FAILURE; DEFORMATION; STEEL; FRAGMENTATION; INITIATION; ELEMENTS AB Many inelastic solids accumulate numerous cracks before failure due to impact loading, thus rendering any exact solution of the IBVP untenable. It is therefore useful to construct computational models that can accurately predict the evolution of damage during actual impact/dynamic events in order to develop design tools for assessing performance characteristics. This paper presents a computational model for predicting the evolution of cracking in structures subjected to dynamic loading. Fracture is modeled via a nonlinear viscoelastic cohesive zone model. Two example problems are shown: one for model validation through comparison with a one-dimensional analytical solution for dynamic viscoelastic debonding, and the other demonstrates the applicability of the approach to model dynamic fracture propagation in the double cantilever beam test with a viscoelastic cohesive zone. Published by Elsevier Ltd. C1 [Gazonas, George A.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Souza, Flavio V.; Allen, David H.] Univ Nebraska, Dept Engn Mech, Lincoln, NE 68588 USA. [Kim, Yong-Rak] Univ Nebraska, Dept Civil Engn, Lincoln, NE 68588 USA. RP Gazonas, GA (reprint author), USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM gazonas@arl.army.mil OI Gazonas, George/0000-0002-2715-016X FU U.S. Army Research Office; CNPq; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - Brazil FX The authors acknowledge the support provided by the U.S. Army Research Office under Cooperative Agreement No. W911NF-04-2-0011. The first author also acknowledges the financial support from CNPq, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - Brazil. NR 43 TC 1 Z9 2 U1 0 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-8368 J9 COMPOS PART B-ENG JI Compos. Pt. B-Eng. PD SEP PY 2009 VL 40 IS 6 BP 483 EP 494 DI 10.1016/j.compositesb.2008.12.004 PG 12 WC Engineering, Multidisciplinary; Materials Science, Composites SC Engineering; Materials Science GA 485HK UT WOS:000269111600010 ER PT J AU Walter, TR Subhash, G Sankar, BV Yen, CF AF Walter, T. R. Subhash, G. Sankar, B. V. Yen, C. F. TI Damage modes in 3D glass fiber epoxy woven composites under high rate of impact loading SO COMPOSITES PART B-ENGINEERING LA English DT Article DE 3-Dimensional reinforcement; Delamination; Impact behavior; Mechanical testing ID TENSILE PROPERTIES; LOW-VELOCITY; THICKNESS REINFORCEMENT; FAILURE MECHANISMS; SYSTEMS; BEHAVIOR; 2D AB A qualitative analysis of experimental results from small caliber ballistic impact and dynamic indentation on a 3D glass fiber reinforced composite are presented. Microscopic analysis of the damaged specimens revealed that the current 3D weaving scheme creates inherently two weak planes which act as potential sites for delamination in the above experiments. It is concluded that while the z-yarns may be effective in limiting the delamination damage at low loads and at low rates of impact, at high loads and high loading rates delamination continues to be the dominant failure mode in 3D woven composites. It is shown that dynamic indentation can be used to capture the progression of damage during impact of 3D woven composites. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Walter, T. R.; Subhash, G.; Sankar, B. V.] Univ Florida, Gainesville, FL 32611 USA. [Yen, C. F.] USA, Res Lab, Survivabil Mat Branch, AMSRD ARL WM MD, Aberdeen Proving Ground, MD 21005 USA. RP Subhash, G (reprint author), Univ Florida, 129-NEB,POB 116250, Gainesville, FL 32611 USA. EM subhash@ufl.edu RI Sankar, Bhavani/F-5193-2011; Walter, Thomas/K-4857-2015; OI Sankar, Bhavani/0000-0002-4556-1982 FU US Army Research Office [W911NF-08-1-0120]; US Army Research Laboratory (ARL); Aberdeen Proving Grounds FX The authors are grateful for the funding provided by the US Army Research Office (Agreement W911NF-08-1-0120, Dr. Bruce LaMattina, Program Manager) and US Army Research Laboratory (ARL), Aberdeen Proving Grounds, MD. Authors are also thankful to ARL personnel for supplying the 3D woven composite material. The authors acknowledge Anton Walter for his assistance in performing the ballistic testing. NR 23 TC 27 Z9 27 U1 2 U2 18 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-8368 J9 COMPOS PART B-ENG JI Compos. Pt. B-Eng. PD SEP PY 2009 VL 40 IS 6 BP 584 EP 589 DI 10.1016/j.compositesb.2009.04.021 PG 6 WC Engineering, Multidisciplinary; Materials Science, Composites SC Engineering; Materials Science GA 485HK UT WOS:000269111600019 ER PT J AU Polonis, VR Schuitemaker, H Bunnik, EM Brown, BK Scarlatti, G AF Polonis, Victoria R. Schuitemaker, Hanneke Bunnik, Evelien M. Brown, Bruce K. Scarlatti, Gabriella TI Impact of host cell variation on the neutralization of HIV-1 in vitro SO CURRENT OPINION IN HIV AND AIDS LA English DT Article DE assay standardization; HIV neutralization; host cell; humoral immunity; vaccine assessment AB Purpose of review In this review we present current advances in our understanding of HIV-1 neutralization assays that employ primary cell types, as compared with those that utilize cell lines and the newer, more standardized pseudovirus assays. A commentary on the challenges of standardizing in-vitro neutralization assays using primary cells is included. Recent findings The data from reporter cell line neutralization assays may agree with results observed in primary cells; however, exceptions have recently been reported. Multiple variables exist in primary cell assays using peripheral blood mononuclear cells from HIV-seronegative donors; in-vitro neutralization titers can vary significantly based on the donor cells used for assay targets and for virus propagation. Thus, more research is required to achieve validated primary cell neutralization assays. Summary HIV-vaccine-induced antibody performance in the current neutralization assays may function as a 'gatekeeper' for HIV-1 subunit vaccine advancement. Development of standardized platforms for reproducible measurement of in-vitro neutralization is therefore a high priority. Given the considerable variation in results obtained from some widely applied HIV neutralization platforms, parallel evaluation of new antibodies using different host cells for assay targets, as well as virus propagation, is recommended until immune correlates of protection are identified. C1 [Polonis, Victoria R.] Walter Reed Army Inst Res, Dept Vaccine Res & Dev, Rockville, MD 20850 USA. [Schuitemaker, Hanneke; Bunnik, Evelien M.] Univ Amsterdam, Acad Med Ctr, Dept Immunol, Landsteiner Lab Sanquin Res, NL-1105 AZ Amsterdam, Netherlands. [Schuitemaker, Hanneke; Bunnik, Evelien M.] Univ Amsterdam, Acad Med Ctr, Ctr Infect & Immun, NL-1105 AZ Amsterdam, Netherlands. [Brown, Bruce K.] Henry M Jackson Fdn, Rockville, MD USA. [Scarlatti, Gabriella] Ist Sci San Raffaele, Dept Immunol Transplantat & Infect Dis, I-20132 Milan, Italy. RP Polonis, VR (reprint author), Walter Reed Army Inst Res, Dept Vaccine Res & Dev, 13 Taft Court,Suite 200, Rockville, MD 20850 USA. EM vpolonis@hivresearch.org FU Henry M. Jackson Foundation for the Advancement of Military Medicine; U.S. Department of Defense; EC [LSSP-CT-2004-012190]; EUROPRISE Network of Excellence of the EU [LSHP CT-2006-037611] FX The views expressed are those of the authors and should not be construed to represent the positions of the US Army or the Department of Defense. This work was supported in part by a cooperative agreement between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the U.S. Department of Defense. The project, 'NeutNet: standardization of HIV neutralization assays to be used in vaccine research and clinical trials' was partially sponsored by EC grant number LSSP-CT-2004-012190, and by the EUROPRISE Network of Excellence of the EU, grant number LSHP CT-2006-037611. We acknowledge the contribution of all laboratories participating in the NeutNet project. NR 83 TC 14 Z9 14 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1746-630X J9 CURR OPIN HIV AIDS JI Curr. Opin. HIV AIDS PD SEP PY 2009 VL 4 IS 5 BP 400 EP 407 DI 10.1097/COH.0b013e32832edc50 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA V19PC UT WOS:000208083300009 PM 20048704 ER PT J AU Price, JA Rogers, JV McDougal, JN Shaw, MQ Reid, FM Graham, JS AF Price, Jennifer A. Rogers, James V. McDougal, James N. Shaw, Morgan Q. Reid, Frances M. Graham, John S. TI Transcriptional changes in porcine skin at 7 days following sulfur mustard and thermal burn injury SO CUTANEOUS AND OCULAR TOXICOLOGY LA English DT Article DE Sulfur mustard; thermal burn injury; skin; porcine; microarray; transcriptional changes ID HUMAN EPIDERMAL-KERATINOCYTES; GENE-EXPRESSION ANALYSIS; PLASMINOGEN-ACTIVATOR; MICROARRAY ANALYSIS; WEANLING SWINE; GROWTH-FACTORS; ATOPIC-DERMATITIS; HEME OXYGENASE-1; S100 PROTEINS; UP-REGULATION AB Severe cutaneous injuries continue to result from exposure to sulfur mustard [bis(2-chloroethyl)sulfide; HD] and thermal burns. Microarray analysis was utilized in this study to evaluate transcriptional changes in porcine skin assessing the underlying repair mechanisms of HD and thermal injury involved in wound healing. Four ventral abdominal sites on each of 4 weanling swine were exposed to 400 mu L undiluted HD or a heated brass rod (70 degrees C) for 8 minutes and 45-60 seconds, respectively. At 7 days postexposure, skin samples were excised and total RNA was isolated, labeled, and hybridized to Affymetrix GeneChip (Santa Clara, CA, USA) Porcine Genome Arrays (containing 20,201 genes). Based on the gene expression patterns in HD- and thermal-exposed skin at 7 days, the transcriptional profiles do not differ greatly. HD and thermal exposures promoted similar changes in transcription, where 270 and 283 transcripts were increased with HD and thermal exposures, respectively. Both exposures promoted decreases in 317 and 414 transcripts, respectively. Of the significantly increased transcripts, at least 77% were commonly expressed in both HD- and thermal-exposed skin, whereas at least 67% of decreased transcripts were common between both exposure types. Six of the top 10 biological functions were common to HD and thermal injury in which 9 canonical pathways were shared. The present study illustrates the similarities found between HD and thermal injury with respect to transcriptional response and wound healing and identifies specific genes (CXCL2, CXCR4, FGFR2, HMOX1, IGF1, PF4, PLAU, PLAUR, S100A8, SPP1, and TNC) that may be useful as potential therapeutic targets to promote improved wound healing. C1 [Price, Jennifer A.; Rogers, James V.; Shaw, Morgan Q.; Reid, Frances M.] Battelle Mem Inst, Biomed Res Ctr, Columbus, OH 43201 USA. [McDougal, James N.] Wright State Univ, Dept Pharmacol & Toxicol, Dayton, OH 45435 USA. [Graham, John S.] USA, Med Res Inst Chem Def, Med Toxicol Branch, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA. RP Rogers, JV (reprint author), Battelle Mem Inst, Biomed Res Ctr, 505 King Ave,JM-7, Columbus, OH 43201 USA. EM rogersjv@battelle.org FU DTRA/CBMS/MRMC [W81XWH-05-D-0001] FX This work was supported by DTRA/CBMS/MRMC Contract W81XWH-05-D-0001, Task Order 0004. NR 82 TC 11 Z9 11 U1 0 U2 3 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1556-9527 J9 CUTAN OCUL TOXICOL JI Cutan. Ocul. Toxicol. PD SEP PY 2009 VL 28 IS 3 BP 129 EP 140 DI 10.1080/15569520903097754 PG 12 WC Ophthalmology; Toxicology SC Ophthalmology; Toxicology GA 504SI UT WOS:000270637200007 PM 19694609 ER PT J AU Rustad, K Henning, S AF Rustad, Kristina Henning, Scott TI Direct Observed "Soak and Smear" Therapy for Severe Eczematous Dermatitis in the Combat Setting SO DERMATITIS LA English DT Article ID ATOPIC-DERMATITIS AB Background: Eczematous dermatitis is difficult to control in a combat setting and may result in a service member's early return to the United States. We report on seven patients with presumed eczematous dermatitis for whom traditional treatments had failed. Objective: To evaluate the effectiveness of "soak and smear" in eczematous dermatitis. Method: The patients were treated with 3 days of direct observed soak and smear therapy with topical steroids. Results: All seven patients significantly improved with treatment, showing a decrease in investigator global assessment, patient self-assessment, and pruritus scores. Conclusion: This study demonstrates that direct observed soak and smear therapy is an effective tool with which to rapidly improve severe eczema. Additionally, this method can be used in the combat environment. C1 [Rustad, Kristina] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Rustad, K (reprint author), Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NR 7 TC 4 Z9 4 U1 0 U2 0 PU B C DECKER INC PI HAMILTON PA 50 KING STREET EAST, 2ND FLOOR, PO BOX 620, L C D 1, HAMILTON, ONTARIO L8N 3K7, CANADA SN 1710-3568 J9 DERMATITIS JI Dermatitis PD SEP-OCT PY 2009 VL 20 IS 5 BP 275 EP 277 DI 10.2310/6620.2009.08113 PG 3 WC Dermatology SC Dermatology GA 503ZY UT WOS:000270583000006 PM 19808003 ER PT J AU Moawad, FJ Veerappan, GR Wong, RK AF Moawad, Fouad J. Veerappan, Ganesh R. Wong, Roy K. TI Eosinophilic Esophagitis SO DIGESTIVE DISEASES AND SCIENCES LA English DT Review DE Eosinophilic esophagitis; Esophageal eosinophilia; Dysphagia; Food impactions ID TOPICAL CORTICOSTEROID TREATMENT; FLUTICASONE PROPIONATE; RINGED ESOPHAGUS; SKIN PRICK; GASTROESOPHAGEAL-REFLUX; MEPOLIZUMAB THERAPY; HISTOLOGIC-FINDINGS; ELIMINATION DIET; PATCH TESTS; CASE SERIES AB Eosinophilic esophagitis is a chronic inflammatory disorder characterized by dense eosinophilic infiltration of the esophageal mucosa. The pathogenesis is incompletely understood and food allergies and aeroallergens have been implicated. The most common clinical presentation in adults is dysphagia to solids. Its associated endoscopic findings are distinct and include concentric rings and longitudinal furrows, although endoscopy may be unremarkable in a minority of patients. A number of management strategies exist; however, data are limited in adults, and only a few are based on randomized controlled trials. Management options include dietary modifications, pharmacological therapy, and endoscopic dilation. C1 [Moawad, Fouad J.; Veerappan, Ganesh R.; Wong, Roy K.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Moawad, FJ (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. EM Fouad.Moawad@amedd.army.mil NR 79 TC 18 Z9 20 U1 0 U2 2 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0163-2116 J9 DIGEST DIS SCI JI Dig. Dis. Sci. PD SEP PY 2009 VL 54 IS 9 BP 1818 EP 1828 DI 10.1007/s10620-009-0873-6 PG 11 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 474ZP UT WOS:000268324000002 PM 19554448 ER PT J AU Graham, JH Krzysik, AJ Kouacic, DA Duda, JJ Freeman, DC Emlen, JM Zak, JC Long, WR Wallace, MP Chamberlin-Graham, C Nutter, JP Balbach, HE AF Graham, John H. Krzysik, Anthony J. Kouacic, David A. Duda, Jeffrey J. Freeman, D. Carl Emlen, John M. Zak, John C. Long, W. Russell Wallace, Michael P. Chamberlin-Graham, Catherine Nutter, Jonathan P. Balbach, Hal E. TI Species richness, equitability, and abundance of ants in disturbed landscapes SO ECOLOGICAL INDICATORS LA English DT Article DE Disturbance; Equitability; Fire; Formicidae; Military training; Spatial heterogeneity; Species richness ID FALL-LINE SANDHILLS; LAND-USE; RECOLONIZATION PATTERNS; FLUCTUATING ASYMMETRY; DIVERSITY GRADIENTS; HABITAT DISTURBANCE; IPOMOEA-PANDURATA; FUNCTIONAL-GROUPS; SOIL DISTURBANCE; RHUS-COPALLINUM AB Ants are used as indicators of environmental change in disturbed landscapes, often without adequate understanding of their response to disturbance. Ant communities in the southeastern United States displayed a hump-backed species richness curve against an index of landscape disturbance. Forty sites at Fort Benning, in west-central Georgia, covered a spectrum of habitat disturbance (military training and fire) in upland forest. Sites disturbed by military training had fewer trees, less canopy cover, more bare ground, and warmer, more compact soils with shallower A-horizons. We sampled ground-dwelling ants with pitfall traps, and measured 15 habitat variables related to vegetation and soil. Ant species richness was greatest with a relative disturbance of 43%, but equitability was greatest with no disturbance. Ant abundance was greatest with a relative disturbance of 85%. High species richness at intermediate disturbance was associated with greater within-site spatial heterogeneity, Species richness was also associated with intermediate values of the normalized difference vegetation index (NDVI), a correlate of net primary productivity (NPP). Available NPP (the product of NDVI and the fraction of days that soil temperature exceeded 25 degrees C), however, was positively correlated with species richness, though not with ant abundance. Species richness was unrelated to soil texture, total ground cover, and fire frequency. Ant species richness and equitability are potential state indicators of the soil arthropod community. Moreover, equitability can be used to monitor ecosystem change. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Graham, John H.; Long, W. Russell; Chamberlin-Graham, Catherine; Nutter, Jonathan P.] Berry Coll, Dept Biol, Mt Berry, GA 30149 USA. [Krzysik, Anthony J.] Prescott Coll, Prescott, AZ 86301 USA. [Kouacic, David A.; Wallace, Michael P.] Univ Illinois, Dept Landscape Architecture, Champaign, IL 61820 USA. [Duda, Jeffrey J.; Emlen, John M.] Western Fisheries Res Ctr, USGS Biol Resources Div, Seattle, WA 98115 USA. [Freeman, D. Carl] Wayne State Univ, Dept Biol Sci, Detroit, MI 48202 USA. [Zak, John C.] Texas Tech Univ, Dept Biol, Lubbock, TX 79409 USA. [Balbach, Hal E.] USA, ERDC CERL, Champaign, IL 61826 USA. RP Graham, JH (reprint author), Berry Coll, Dept Biol, Mt Berry, GA 30149 USA. EM jgraham@berry.edu RI Duda, Jeffrey/A-7132-2009; OI Duda, Jeffrey/0000-0001-7431-8634; Graham, John/0000-0003-1974-132X FU Department of Defense SERDP (Strategic Environmental Research and Development Program) FX This research was sponsored by the Department of Defense SERDP (Strategic Environmental Research and Development Program) and is Part of the SERDP Ecosystem Management Project (SEMP). Student research assistants of JHG were funded, in part, by Berry College. Michelle Brown and Lorence Pascoe helped with the fieldwork. And we thank Pete Swiderek, Theresa Davo, and John Brent of Fort Benning, and Hugh Westbury and Patti Kosky of SERDP-SEMP for logistics and coordination with Fort Benning Range Control. We thank John Dilustro for advice on NPP. Conservation and Land Management branches at Fort Benning provided the fire data. Bob Lozar (U.S. Army ERDC-CERL) developed the NDVI data. Mark Deyrup, Stefan Cover, William Mackay, and James Trager offered numerous suggestions on ant taxonomy, identification, and natural history. Alan Andersen, Jerry Freilich, David Foote, and an unknown reviewer offered numerous helpful suggestions on the manuscript. The use of trade, firm, or corporation names in this publication is for the information and convenience of the reader. Such use does not constitute an official endorsement or approval by the United States Department of Interior or the United States Geologic Survey of any product or service to the exclusion of others that may be suitable. NR 88 TC 19 Z9 19 U1 6 U2 37 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1470-160X J9 ECOL INDIC JI Ecol. Indic. PD SEP PY 2009 VL 9 IS 5 BP 866 EP 877 DI 10.1016/j.ecolind.2008.10.003 PG 12 WC Biodiversity Conservation; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 426YI UT WOS:000264744100005 ER PT J AU Groffman, PM Hardy, JP Fisk, MC Fahey, TJ Driscoll, CT AF Groffman, Peter M. Hardy, Janet P. Fisk, Melany C. Fahey, Timothy J. Driscoll, Charles T. TI Climate Variation and Soil Carbon and Nitrogen Cycling Processes in a Northern Hardwood Forest SO ECOSYSTEMS LA English DT Review DE carbon dioxide; climate change; mineralization; nitrification; nitrous oxide; methane ID NORTHEASTERN UNITED-STATES; LAND-USE HISTORY; TEMPERATE FOREST; WATER DYNAMICS; OXIDE FLUXES; TERRESTRIAL ECOSYSTEMS; HEADWATER CATCHMENTS; ADIRONDACK MOUNTAINS; LANDSCAPE POSITION; ELEVATION GRADIENT AB We exploited the natural climate gradient in the northern hardwood forest at the Hubbard Brook Experimental Forest (HBEF) to evaluate the effects of climate variation similar to what is predicted to occur with global warming over the next 50-100 years for northeastern North America on soil carbon (C) and nitrogen (N) cycle processes. Our objectives were to (1) characterize differences in soil temperature, moisture and frost associated with elevation at the HBEF and (2) evaluate variation in total soil (TSR) and microbial respiration, N mineralization, nitrification, denitrification, nitrous oxide (N(2)O) flux, and methane (CH(4)) uptake along this gradient. Low elevation sites were consistently warmer (1.5-2.5 degrees C) and drier than high elevation sites. Despite higher temperatures, low elevation plots had less snow and more soil frost than high elevation plots. Net N mineralization and nitrification were slower in warmer, low elevation plots, in both summer and winter. In summer, this pattern was driven by lower soil moisture in warmer soils and in winter the pattern was linked to less snow and more soil freezing in warmer soils. These data suggest that N cycling and supply to plants in northern hardwood ecosystems will be reduced in a warmer climate due to changes in both winter and summer conditions. TSR was consistently faster in the warmer, low elevation plots. N cycling processes appeared to be more sensitive to variation in soil moisture induced by climate variation, whereas C cycling processes appeared to be more strongly influenced by temperature. C1 [Groffman, Peter M.] Cary Inst Ecosyst Studies, Millbrook, NY 12545 USA. [Hardy, Janet P.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Fisk, Melany C.] Miami Univ, Dept Zool, Oxford, OH 45056 USA. [Fahey, Timothy J.] Cornell Univ, Dept Nat Resources, Ithaca, NY 14853 USA. [Driscoll, Charles T.] Syracuse Univ, Dept Civil & Environm Engn, Syracuse, NY 13244 USA. RP Groffman, PM (reprint author), Cary Inst Ecosyst Studies, Millbrook, NY 12545 USA. EM groffmanp@caryinstitute.org RI yang, lixia/D-7815-2011; Driscoll, Charles/F-9832-2014; OI Driscoll, Charles/0000-0003-2692-2890 FU US National Science Foundation [DEB 98-10221]; DEB [00-75387] FX We thank Lisa Martel for excellent field, laboratory, and data analysis work. This research was supported by US National Science Foundation Grants DEB 98-10221 (Hubbard Brook Long Term Ecological Research) and DEB 00-75387 (Ecosystem Studies). This research was conducted at the Hubbard Brook Experimental Forest, which is operated by the Northeastern Research Station, USDA Forest Service, Newtown Square, PA. This paper is a contribution to the Hubbard Brook Ecosystem Study. NR 104 TC 56 Z9 60 U1 7 U2 104 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1432-9840 J9 ECOSYSTEMS JI Ecosystems PD SEP PY 2009 VL 12 IS 6 BP 927 EP 943 DI 10.1007/s10021-009-9268-y PG 17 WC Ecology SC Environmental Sciences & Ecology GA 500XJ UT WOS:000270339300005 ER PT J AU Kuchuloria, T Clark, DV Hepburn, MJ Tsertsvadze, T Pimentel, G Imnadze, P AF Kuchuloria, Tinatin Clark, Danielle V. Hepburn, Matthew J. Tsertsvadze, Tengiz Pimentel, Guillermo Imnadze, Paata TI Hantavirus Infection in the Republic of Georgia SO EMERGING INFECTIOUS DISEASES LA English DT Article ID MOUSE APODEMUS-AGRARIUS; DOBRAVA HANTAVIRUS; EUROPE AB We describe a laboratory-confirmed case of hantavirus infection in the Republic of Georgia. Limited information is available about hantavirus infections in the Caucasus, although the infection has been reported throughout Europe and Russia. Increasing awareness and active disease surveillance contribute to our improved understanding of the geographic range of this pathogen. C1 [Kuchuloria, Tinatin] Technol Management Co, GE-0105 Tbilisi, Rep of Georgia. [Clark, Danielle V.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Hepburn, Matthew J.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Tsertsvadze, Tengiz] AIDS & Clin Immunol SP Ctr, Tbilisi, Rep of Georgia. [Pimentel, Guillermo] Naval Med Res Unit 3, Cairo, Egypt. [Imnadze, Paata] Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia. RP Kuchuloria, T (reprint author), Technol Management Co, 4 Freedom Sq, GE-0105 Tbilisi, Rep of Georgia. EM drkuchuloria@yahoo.com RI Valle, Ruben/A-7512-2013; OI Pimentel, Guillermo/0000-0003-2464-1526 FU US Department of Defense, Global Emergence infections Surveillance Program; Centers for Disease Control and Prevention, International Emerging Infections Program in Egypt FX This study was supported by the US Department of Defense, Global Emergence infections Surveillance Program, and by the Centers for Disease Control and Prevention, International Emerging Infections Program in Egypt. NR 9 TC 7 Z9 7 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD SEP PY 2009 VL 15 IS 9 BP 1489 EP 1491 DI 10.3201/eid1509.090617 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 490NK UT WOS:000269507500025 PM 19788822 ER PT J AU Pichyangkul, S Jongkaewwattana, A Thitithanyanont, A Ekchariyawat, P Wiboon-ut, S Limsalakpetch, A Yongvanitchit, K Kum-Arb, U Mahanonda, R Utaisincharoen, P Sirisinha, S Mason, CJ Fukuda, MM AF Pichyangkul, Sathit Jongkaewwattana, Anan Thitithanyanont, Arunee Ekchariyawat, Peeraya Wiboon-ut, Suwimon Limsalakpetch, Amporn Yongvanitchit, Kosol Kum-Arb, Utaiwan Mahanonda, Rangsini Utaisincharoen, Pongsak Sirisinha, Stitaya Mason, Carl J. Fukuda, Mark M. TI Cross-reactive Antibodies against Avian Influenza Virus A (H5N1) SO EMERGING INFECTIOUS DISEASES LA English DT Letter ID INTRAVENOUS IMMUNOGLOBULIN; MATRIX PROTEIN-2; AUTOIMMUNE; PROTECTION; CELLS C1 [Pichyangkul, Sathit] Armed Forces Res Inst Med Sci, US Army Med Component, Dept Immunol & Med, Bangkok 10400, Thailand. [Jongkaewwattana, Anan] Natl Ctr Genet Engn & Biotechnol, Bangkok, Thailand. [Thitithanyanont, Arunee; Ekchariyawat, Peeraya; Wiboon-ut, Suwimon; Utaisincharoen, Pongsak; Sirisinha, Stitaya] Mahidol Univ, Bangkok 10700, Thailand. [Mahanonda, Rangsini] Chulalongkorn Univ, Bangkok, Thailand. RP Pichyangkul, S (reprint author), Armed Forces Res Inst Med Sci, US Army Med Component, Dept Immunol & Med, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM sathitp@afrims.org RI Jongkaewwattana, Anan/F-1324-2011; OI MASON, CARL/0000-0002-3676-2811 FU NIAID NIH HHS [Y1-AI-5026-01] NR 10 TC 6 Z9 6 U1 0 U2 0 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD SEP PY 2009 VL 15 IS 9 BP 1537 EP 1539 DI 10.3201/eid1509.090471 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 490NK UT WOS:000269507500043 PM 19788839 ER PT J AU Yacoub, CA Gaitonde, MDY Wood, LCJC AF Yacoub, Captain Ator Gaitonde, Major David Y. Wood, Lieutenant Colonel Joseph C. TI THYMIC HYPERPLASIA AND GRAVES DISEASE: MANAGEMENT OF ANTERIOR MEDIASTINAL MASSES IN PATIENTS WITH GRAVES DISEASE SO ENDOCRINE PRACTICE LA English DT Article ID MYASTHENIA-GRAVIS; HYPERTHYROIDISM; ENLARGEMENT; GLAND AB Objective: To describe a case of an anterior mediastinal mass (AMM) in a patient with Graves disease. Methods: We report the clinical presentation, diagnosis, management, and outcome of a 34-year-old man with dyspnea on exertion. Results: Initial evaluation of the patient's complaints revealed a large AMM on chest radiography and then chest computed tomography. After occurrence of additional symptoms, the patient was diagnosed as having Graves disease and treated with antithyroid medications. Despite an appropriate biochemical response, he continued to experience severe dyspnea on exertion. A repeated computed tomographic scan 8 weeks after initiation of therapy showed no appreciable decrease in size of the AMM. He elected to undergo thymectomy. An intracoperative phrenic nerve injury resulted in a paralyzed left hemidiaphragm, leaving the patient with considerable difficulties in his career and profoundly decreased exercise tolerance. Conclusion: The differential diagnosis of an AMM includes several malignant lesions with a risk often warranting early surgical excision. In light of the association of benign thymic hyperplasia with Graves disease, thymectomy may be delayed in expectation of thymic regression with medical therapy. The timing of regression is variable, and very few reports exist in the literature. In our current case, the patient opted for thymectomy relatively early and had an unfortunate complication. The lack of clinical evidence regarding management of an enlarged thymus in patients with Graves disease, however, makes management decisions more difficult. (Endocr Pract. 2009; 15: 534-539) C1 [Yacoub, Captain Ator] Dwight D Eisenhower Army Med Ctr, Dept Med, Ft Gordon, GA 30905 USA. RP Yacoub, CA (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Med, 300 E Hosp Rd, Ft Gordon, GA 30905 USA. NR 27 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CLIN ENDOCRINOL PI JACKSONVILLE PA 1000 RIVERSIDE AVE, STE 205, JACKSONVILLE, FL 32204 USA SN 1530-891X J9 ENDOCR PRACT JI Endocr. Pract. PD SEP-OCT PY 2009 VL 15 IS 6 BP 534 EP 539 DI 10.4158/EP09025.ORR PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 520EP UT WOS:000271823300004 ER PT J AU Kennedy, AJ Gunter, JC Chappell, MA Goss, JD Hull, MS Kirgan, RA Steevens, JA AF Kennedy, Alan J. Gunter, Jonas C. Chappell, Mark A. Goss, Jennifer D. Hull, Matthew S. Kirgan, Robert A. Steevens, Jeffery A. TI INFLUENCE OF NANOTUBE PREPARATION IN AQUATIC BIOASSAYS SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Nanotube; Toxicity; Ceriodaphnia; Leptocheirus; Hyalella ID WALLED CARBON NANOTUBES; FULLERENE C-60 NANOPARTICLES; DAPHNIA-MAGNA; TOXICITY; WATER; NANOMATERIALS; ENVIRONMENT; AMPHIPOD; ECOTOXICOLOGY; AGGREGATION AB Knowledge gaps in nanomaterial fate and toxicity currently limit the ability of risk assessments to characterize the environmental implications of nanomaterials. This problem is further complicated by the lack of standardized characterization and preparation methodologies for researchers to gain the needed information to assist risk assessors. In the present study, data were generated to determine if multiwalled nanotube (MWNT) fate and toxicity are altered by engineered surface modifications or by different dispersal methods. While dissolved organic matter was a good dispersing agent of MWNTs in water, the humic acid fraction was a more effective dispersant than the fulvic acid fraction. When stabilized in organic matter, the functional group attached to the MWNT controlled its toxicity. Underivatized MWNTs induced relatively moderate toxicity to Ceriodaphnia dubia after 96 h (25 +/- 19% survival at 26 mg/L), while hydrophilic groups (hydroxyl, carboxyl) reduced this toxicity (93 +/- 12% survival at 48 mg/L). However, other functional groups (alkyl, amine) increased toxicity (0 +/- 0% survival at <15 mg/L). In dispersal method studies, sonication of MWNTs increased fragmentation relative to magnetic stirring. The sonication treatment of MWNTs also slightly reduced the mortality of C. dubia in the water column but increased toxicity in the sediment to Leptocheirus plumulosus and Hyalella azteca. Findings in the present study indicate that nanotubes engineered for specific applications need to be managed independently and that laboratory methods to disperse and test nanotubes in bioassays need to be standardized to obtain repeatable results for comparison of materials. C1 [Kennedy, Alan J.; Chappell, Mark A.; Kirgan, Robert A.; Steevens, Jeffery A.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Gunter, Jonas C.] Luna Innovat, Blacksburg, VA 24060 USA. [Goss, Jennifer D.] Spec Pro, Vicksburg, MS 39180 USA. [Hull, Matthew S.] Virginia Polytech Inst & State Univ, Dept Civil & Environm Engn, Blacksburg, VA 24061 USA. RP Kennedy, AJ (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM alan.j.kennedy@usace.army.mil RI Hull, Matt/F-4942-2012 NR 40 TC 48 Z9 48 U1 4 U2 34 PU SETAC PRESS PI PENSACOLA PA 1010 N 12TH AVE, PENSACOLA, FL 32501-3367 USA SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD SEP PY 2009 VL 28 IS 9 BP 1930 EP 1938 PG 9 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 482HT UT WOS:000268876200019 PM 19388791 ER PT J AU Kirchner, JE AF Kirchner, John E. TI Division of Military Retired Pay SO FAMILY LAW QUARTERLY LA English DT Article C1 [Kirchner, John E.] USA, JAGC, Colorado Springs, CO USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER BAR ASSOC, ADMINISTRATIVE LAW & REGULATORY PRACTICE SECTION PI CHICAGO PA 321 N CLARK ST, CHICAGO, IL 60610 USA SN 0014-729X J9 FAM LAW QUART JI Fam. Law Q. PD FAL PY 2009 VL 43 IS 3 BP 367 EP 438 PG 72 WC Family Studies; Law SC Family Studies; Government & Law GA 545VG UT WOS:000273764500001 ER PT J AU Beidleman, BA Fulco, CS Muza, SR Rock, PB Staab, JE Forte, VA Brothers, MD Cymerman, A AF Beidleman, Beth A. Fulco, Charles S. Muza, Stephen R. Rock, Paul B. Staab, Janet E. Forte, Vincent A. Brothers, Michael D. Cymerman, Allen TI Effect of Six Days of Staging on Physiologic Adjustments and Acute Mountain Sickness during Ascent to 4300 Meters SO HIGH ALTITUDE MEDICINE & BIOLOGY LA English DT Article DE hypobaric hypoxia; arterial oxygen saturation; resting ventilation; heart rate; mean arterial pressure ID MODERATE ALTITUDE; SIMULATED ALTITUDE; HEMOGLOBIN MASS; BLOOD-VOLUME; ACCLIMATIZATION; SYMPTOMS; SUSCEPTIBILITY; QUESTIONNAIRE; RESPONSES; AMS AB Beidleman, Beth A., Charles S. Fulco, Stephen R. Muza, Paul R. Rock, Janet E. Staab, Vincent A. Forte, Michael D. Brothers, and Allen Cymerman. Effect of six days of staging on physiological adjustments and acute mountain sickness during ascent to 4300 meters. High Alt. Med. Biol. 10: 253-260, 2009.- This study determined the effectiveness of 6 days (d) of staging at 2200 m on physiologic adjustments and acute mountain sickness (AMS) during rapid, high-risk ascent to 4300 m. Eleven sea-level (SL) resident men (means +/- SD; 21 +/- 3 yr; 78 +/- 13 kg) completed resting measures of end-tidal CO(2) (PETCO(2)), arterial oxygen saturation (Sao(2)), heart rate (HR), and mean arterial pressure (MAP) at SL and within 1 h of exposure to 4300 m in a hypobaric chamber prior to 6 d of staging at 2200 m (preSTG) and on the summit of Pikes Peak following 6 d of staging at 2200 m (postSTG). Immediately following resting ventilation measures, all performed submaximal exercise (similar to 55% of altitude-specific maximal oxygen uptake) for similar to 2 h on a bicycle ergometer to induce higher levels of AMS. AMS-C, calculated from the Environmental Symptoms Questionnaire, was measured following 4 h and 8 h of exposure at preSTG and postSTG, and the mean was calculated. Resting PETCO(2) (mmHg) was unchanged from SL (39.8 +/- 2.6) to preSTG (39.3 +/- 3.0), but decreased (p<0.05) from preSTG to postSTG (32.8 +/- 2.6). Resting Sao(2) (%) decreased (p<0.05) from SL (97 +/- 2) to preSTG (80 +/- 4) and increased (p<0.05) from preSTG to postSTG (83 +/- 3). Resting HR (bpm) and MAP ( mmHg) did not change in any of the test conditions. The incidence and severity of AMS-C decreased (p<0.05) from preSTG (91 +/- 30%; 1.05 +/- 0.56) to postSTG (45 +/- 53%; 0.59 +/- 0.43), respectively. These results suggest that modest physiologic adjustments induced by staging for 6 d at 2200 m reduced the incidence and severity of AMS during rapid, high-risk ascent to 4300 m. C1 [Beidleman, Beth A.; Fulco, Charles S.; Muza, Stephen R.; Staab, Janet E.; Forte, Vincent A.; Cymerman, Allen] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. [Rock, Paul B.] Oklahoma State Univ, Ctr Hlth Sci, Ctr Aerosp & Hyperbar Med, Tulsa, OK USA. [Brothers, Michael D.] USAF Acad, Human Performance Lab, Colorado Springs, CO 80840 USA. RP Beidleman, BA (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St, Natick, MA 01760 USA. EM beth.beidleman@us.army.mil NR 32 TC 30 Z9 34 U1 0 U2 6 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1527-0297 J9 HIGH ALT MED BIOL JI High Alt. Med. Biol. PD SEP PY 2009 VL 10 IS 3 BP 253 EP 260 DI 10.1089/ham.2009.1004 PG 8 WC Biophysics; Public, Environmental & Occupational Health; Sport Sciences SC Biophysics; Public, Environmental & Occupational Health; Sport Sciences GA 498BB UT WOS:000270109000007 PM 19775215 ER PT J AU Maass, JR AF Maass, John R. TI Cultures in Conflict: The Seven Years' War in North America SO HISTORIAN LA English DT Book Review C1 [Maass, John R.] USA, Ctr Mil Hist, Washington, DC USA. RP Maass, JR (reprint author), USA, Ctr Mil Hist, Washington, DC USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0018-2370 J9 HISTORIAN JI Historian PD FAL PY 2009 VL 71 IS 3 BP 601 EP 603 PG 3 WC History SC History GA 493NF UT WOS:000269743100020 ER PT J AU Kiesling, EC AF Kiesling, Eugenia C. TI The Roman Army: A Social and Institutional History SO HISTORIAN LA English DT Book Review C1 [Kiesling, Eugenia C.] US Mil Acad, West Point, NY 10996 USA. RP Kiesling, EC (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0018-2370 J9 HISTORIAN JI Historian PD FAL PY 2009 VL 71 IS 3 BP 664 EP 665 PG 2 WC History SC History GA 493NF UT WOS:000269743100066 ER PT J AU Walter, RJ AF Walter, Robert J. TI Theological Bioethics: Participation, Justice, and Change SO HORIZONS LA English DT Book Review C1 [Walter, Robert J.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Walter, RJ (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU COLL THEOLOGY SOC PI VILLANOVA PA HORIZONS, VILLANOVA UNIV, VILLANOVA, PA 19085 USA SN 0360-9669 J9 HORIZONS JI Horizons PD FAL PY 2009 VL 35 IS 2 BP 402 EP 403 PG 2 WC Religion SC Religion GA 519GH UT WOS:000271752500034 ER PT J AU Hale, PS Arno, RG AF Hale, Peyton S., Jr. Arno, Robert G. TI OPERATIONAL AND MAINTENANCE DATA COLLECTION SO IEEE INDUSTRY APPLICATIONS MAGAZINE LA English DT Article CT 39th Annual Meeting of the IEEE-Industry-Applications-Society CY OCT 03-07, 2004 CL Seattle, WA SP IEEE Ind Applicat Soc DE Maintenance engineering; Databases; Availability; Power system reliability; Data mining; Reliability engineering C1 [Hale, Peyton S., Jr.] USA, Corps Engineers, Ft Belvoir, VA USA. [Arno, Robert G.] EYP Crit Facil Serv, Whitesboro, NY USA. RP Hale, PS (reprint author), USA, Corps Engineers, Ft Belvoir, VA USA. EM rarno@hp.com NR 6 TC 0 Z9 0 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1077-2618 J9 IEEE IND APPL MAG JI IEEE Ind. Appl. Mag. PD SEP-OCT PY 2009 VL 15 IS 5 BP 21 EP 24 DI 10.1109/MIAS.2009.933400 PG 4 WC Engineering, Industrial; Engineering, Electrical & Electronic SC Engineering GA 485WM UT WOS:000269155500009 ER PT J AU Anandkumar, A Yukich, JE Tong, L Swami, A AF Anandkumar, Animashree Yukich, Joseph E. Tong, Lang Swami, Ananthram TI Energy Scaling Laws for Distributed Inference in Random Fusion Networks SO IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS LA English DT Article DE Distributed inference; graphical models; Euclidean random graphs; stochastic geometry and data fusion ID WIRELESS SENSOR NETWORKS; MINIMAL SPANNING-TREES; LARGE NUMBERS; ALGORITHMS; GEOMETRY AB The energy scaling laws of multihop data fusion networks for distributed inference are considered. The fusion network consists of randomly located sensors distributed i.i.d. according to a general spatial distribution in an expanding region. Under Markov random field (MRF) hypotheses, among the class of data-fusion policies which enable optimal statistical inference at the fusion center using all the sensor measurements, the policy with the minimum average energy consumption is bounded below by the average energy of fusion along the minimum spanning tree, and above by a suboptimal policy, referred to as Data Fusion for Markov Random Fields (DFMRF). Scaling laws are derived for the energy consumption of the optimal and suboptimal fusion policies. It is shown that the average asymptotic energy of the DFMRF scheme is strictly finite for a class of MRF models with Euclidean stabilizing dependency graphs. C1 [Anandkumar, Animashree; Tong, Lang] Cornell Univ, Sch Elect & Comp Engn, Ithaca, NY 14853 USA. [Yukich, Joseph E.] Lehigh Univ, Dept Math, Bethlehem, PA 18015 USA. [Swami, Ananthram] Army Res Lab, Adelphi, MD 20783 USA. RP Anandkumar, A (reprint author), Cornell Univ, Sch Elect & Comp Engn, Ithaca, NY 14853 USA. EM aa332@cornell.edu; joseph.yukich@lehigh.edu; ltong@ece.cornell.edu; a.swami@ieee.org FU U. S. Army Research Laboratory [DAAD19-01-2-0011]; Army Research Office [ARO-W911NF-06-1-0346]; IBM Ph. D Fellowship; NSA [H98230-06-1-0052]; NSF [DMS-0805570] FX This work was supported in part through collaborative participation in Communications and Networks Consortium sponsored by the U. S. Army Research Laboratory under the Collaborative Technology Alliance Program, Cooperative Agreement DAAD19-01-2-0011 and by the Army Research Office under Grant ARO-W911NF-06-1-0346. The first author is supported by the IBM Ph. D Fellowship for the year 2008-09 and is currently a visiting student at MIT, Cambridge, MA 02139. The second author was partially supported by NSA grant H98230-06-1-0052 and NSF grant DMS-0805570. The U. S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation thereon. NR 53 TC 5 Z9 5 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0733-8716 EI 1558-0008 J9 IEEE J SEL AREA COMM JI IEEE J. Sel. Areas Commun. PD SEP PY 2009 VL 27 IS 7 BP 1203 EP 1217 DI 10.1109/JSAC.2009.090916 PG 15 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 489AR UT WOS:000269392400016 ER PT J AU Ren, W Zhao, Q Swami, A AF Ren, Wei Zhao, Qing Swami, Ananthram TI Power Control in Cognitive Radio Networks: How to Cross a Multi-Lane Highway SO IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS LA English DT Article; Proceedings Paper CT 33rd IEEE International Conference on Acoustics, Speech and Signal Processing CY MAR 30-APR 04, 2008 CL Las Vegas, NV DE Power Control; Cognitive Radio; Opportunistic Spectrum Access; Transport Throughput; Poisson Random Network ID SPECTRUM ACCESS AB We consider power control in cognitive radio networks where secondary users identify and exploit instantaneous and local spectrum opportunities without causing unacceptable interference to primary users. We qualitatively characterize the impacts of the transmission power of secondary users on the occurrence of spectrum opportunities and the reliability of opportunity detection. Based on a Poisson model of the primary network, we quantify these impacts by showing that (i) the probability of spectrum opportunity decreases exponentially with the transmission power of secondary users, where the exponential decay constant is given by the traffic load of primary users; (ii) reliable opportunity detection is achieved in the two extreme regimes in terms of the ratio between the transmission power of secondary users and that of primary users. Such analytical characterizations allow us to study power control for optimal transport throughput under constraints on the interference to primary users. Furthermore, we reveal the difference between detecting primary signals and detecting spectrum opportunities, and demonstrate the complex relationship between physical layer spectrum sensing and MAC layer throughput. The dependency of this PHY-MAC interaction on the application type and the use of handshake signaling such as RTS/CTS is also illustrated. C1 [Ren, Wei; Zhao, Qing] Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95616 USA. [Swami, Ananthram] Army Res Lab, Adelphi, MD 20783 USA. RP Ren, W (reprint author), Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95616 USA. EM qzhao@ece.ucdavis.edu NR 19 TC 73 Z9 74 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0733-8716 J9 IEEE J SEL AREA COMM JI IEEE J. Sel. Areas Commun. PD SEP PY 2009 VL 27 IS 7 BP 1283 EP 1296 DI 10.1109/JSAC.2009.090923 PG 14 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 489AR UT WOS:000269392400023 ER PT J AU Regli, WC Mayk, I Dugan, CJ Kopena, JB Lass, RN Modi, PJ Mongan, WM Salvage, JK Sultanik, EA AF Regli, William C. Mayk, Israel Dugan, Christopher J. Kopena, Joseph B. Lass, Robert N. Modi, Pragnesh Jay Mongan, William M. Salvage, Jeff K. Sultanik, Evan A. TI Development and Specification of a Reference Model for Agent-Based Systems SO IEEE TRANSACTIONS ON SYSTEMS MAN AND CYBERNETICS PART C-APPLICATIONS AND REVIEWS LA English DT Article DE Agents; distributed artificial intelligence (AI); multiagent; reference model; reverse engineering; software engineering ID COMMUNICATION; ARCHITECTURE; INTERNET; MOBILITY; DESIGN AB Agent-based systems have been the object of intense research over the past decade. While great theoretical progress has been made, the software frameworks for creating agent-based systems offer considerable variability in their capabilities and functionality. This paper introduces a reference model for agent-based systems. The purpose of a reference model is to provide a common conceptual basis for comparing systems and driving the development of software architectures and other standards. The Foundation for Intelligent Physical Agents and other groups have advanced a number of agent standards, yet, to date, no comprehensive reference model has been presented for software systems composed of agents. This paper provides an overview of a reference model for agent-based systems. The agent systems reference model is the result of a multiyear effort studying software systems built with agents and software frameworks for implementing these systems. As part of this study, the team applied software reverse engineering techniques to perform static and dynamic analysis of operational agent-based systems. This analysis enabled identification of key common concepts across over one dozen different agent frameworks. To demonstrate its applicability, the reference model is then used to analyze a number of complete agent-based software systems. It is the belief of the authors that the reference model will be an essential prerequisite for future transition, deployment, and integration of agent-based systems. C1 [Regli, William C.; Dugan, Christopher J.; Kopena, Joseph B.; Lass, Robert N.; Modi, Pragnesh Jay; Mongan, William M.; Salvage, Jeff K.; Sultanik, Evan A.] Drexel Univ, Dept Comp Sci, Philadelphia, PA 19147 USA. [Mayk, Israel] USA, Res Dev & Engn Command RDECOM, Commun Elect Res Dev & Engn Ctr CERDEC C2D, Ft Monmouth, NJ 07703 USA. RP Regli, WC (reprint author), Drexel Univ, Dept Comp Sci, Philadelphia, PA 19147 USA. EM regli@drexel.edu; israel.mayk@us.army.mil; cjd48@cs.drexel.edu; tjkopena@cs.drexel.edu; urlass@cs.drexel.edu; wmm24@drexel.edu; jks29@drexel.edu; eas28@cs.drexel.edu NR 50 TC 13 Z9 13 U1 0 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1094-6977 J9 IEEE T SYST MAN CY C JI IEEE Trans. Syst. Man Cybern. Part C-Appl. Rev. PD SEP PY 2009 VL 39 IS 5 BP 572 EP 596 DI 10.1109/TSMCC.2009.2020507 PG 25 WC Computer Science, Artificial Intelligence; Computer Science, Cybernetics; Computer Science, Interdisciplinary Applications SC Computer Science GA 485WP UT WOS:000269155800007 ER PT J AU Avolio, BJ Hannah, ST AF Avolio, Bruce J. Hannah, Sean T. TI Leader Developmental Readiness SO INDUSTRIAL AND ORGANIZATIONAL PSYCHOLOGY-PERSPECTIVES ON SCIENCE AND PRACTICE LA English DT Article C1 [Avolio, Bruce J.] Univ Washington, Michael G Foster Sch Business, Dept Management & Org, Seattle, WA 98195 USA. [Hannah, Sean T.] US Mil Acad, Army Ctr Excellence Profess Mil Eth, West Point, NY USA. RP Avolio, BJ (reprint author), Univ Washington, Michael G Foster Sch Business, Dept Management & Org, Seattle, WA 98195 USA. EM bavolio@u.washington.edu NR 13 TC 6 Z9 6 U1 0 U2 7 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1754-9426 J9 IND ORGAN PSYCHOL-US JI Ind. Organ. Psychol. PD SEP PY 2009 VL 2 IS 3 BP 284 EP 287 DI 10.1111/j.1754-9434.2009.01150.x PG 4 WC Psychology, Applied SC Psychology GA V16ZR UT WOS:000207908000009 ER PT J AU Benden, M Pickens, A AF Benden, Mark Pickens, Adam TI Evaluation Day SO INDUSTRIAL ENGINEER LA English DT Article C1 [Benden, Mark] USA, Reserves Corps Engn, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INST INDUSTRIAL ENGINEERS PI NORCROSS PA 3577 PARKWAY LANE, STE 200, NORCROSS, GA 30092 USA SN 1542-894X J9 IND ENG JI Ind. Eng PD SEP PY 2009 VL 41 IS 9 BP 46 EP 49 PG 4 WC Engineering, Industrial SC Engineering GA V18MT UT WOS:000208009600019 ER PT J AU Sandbulte, MR Gao, J Straight, TM Eichelberger, MC AF Sandbulte, Matthew R. Gao, Jin Straight, Timothy M. Eichelberger, Maryna C. TI A miniaturized assay for influenza neuraminidase-inhibiting antibodies utilizing reverse genetics-derived antigens SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Article DE Influenza virus; miniaturized assay; neuraminidase; reverse genetics ID A VIRUS; INFECTION; VACCINE; HEMAGGLUTININ; IMMUNITY; MICE AB Background Antibodies to neuraminidase (NA) contribute to protection during influenza virus infection, but NA inhibition (NI) titers are not routinely analyzed in vaccine trials. One reason is the cumbersome nature of the conventional thiobarbituric acid (TBA) NI assay, which uses chemical methods to quantify free sialic acid following incubation of NA with substrate in the presence of serum. In addition, the assay is complicated by the need to use virus of a hemagglutinin (HA) subtype novel to the host to detect NA-specific antibodies only. Objectives Our primary objectives were to miniaturize the colorimetric NI assay to a format suitable for quantitative analysis of large numbers of samples, and validate the specificity and sensitivity of the miniaturized format with ferret and human sera. An additional aim was to use reverse genetics to construct HA-mismatched viral reagents bearing NA of recent influenza A vaccine strains and H6 HA. Results Analysis of ferret antisera by the miniaturized assay demonstrated sensitivity and specificity comparable with the conventional assay. Similar increases in the NI titers in sera from vaccinated human volunteers were measured in miniaturized and conventional assays. Inactivated and live-attenuated vaccines increased NI titers against a given subtype at approximately the same rate. Conclusions The reagents and miniaturized format of the TBA method described here provide a platform for practical serological monitoring of functional antibodies against NA. C1 [Sandbulte, Matthew R.; Gao, Jin; Eichelberger, Maryna C.] US FDA, Div Viral Prod, Ctr Biol Evaluat & Res, Bethesda, MD 20014 USA. [Straight, Timothy M.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Sandbulte, MR (reprint author), Room 1D20,Bldg 29A,8800 Rockville Pike, Bethesda, MD 20892 USA. EM matthew.sandbulte@fda.hhs.gov NR 25 TC 44 Z9 44 U1 1 U2 2 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1750-2640 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD SEP PY 2009 VL 3 IS 5 BP 233 EP 240 DI 10.1111/j.1750-2659.2009.00094.x PG 8 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA 484YM UT WOS:000269086700008 PM 21462400 ER PT J AU Krakauer, T Buckley, MJ Huzella, LM Alves, DA AF Krakauer, Teresa Buckley, Marilyn J. Huzella, Louis M. Alves, Derron A. TI Critical timing, location and duration of glucocorticoid administration rescue mice from superantigen-induced shock and attenuate lung injury SO INTERNATIONAL IMMUNOPHARMACOLOGY LA English DT Article DE Superantigens; Shock; Glucocorticoid; Cytokines; Lung ID STAPHYLOCOCCAL-ENTEROTOXIN-B; ACUTE RESPIRATORY SYNDROME; NECROSIS-FACTOR-ALPHA; TRANSGENIC MICE; BACTERIAL SUPERANTIGENS; INTRANASAL EXPOSURE; IMMUNE-RESPONSE; UNITED-STATES; SEVERE SEPSIS; HUMAN-DISEASE AB Bacterial superantigens, such as staphylococcal enterotoxin B (SEB), are major virulence factors implicated in the pathogenesis of toxic shock. In this study we investigated the efficacy of glucocorticoid therapy in preventing SEB-induced lethal shock initiated through the respiratory route in mice. Dexamethasone, a potent anti-inflammatory steroid, administrated intranasally on the first day, followed by intraperitoneal doses on the subsequent 4 days, was effective in attenuating SEB-induced hypothermia, and reduction in systemic and pulmonary proinflammatory mediator release. This optimal dosing and schedule of glucocorticoid treatment mitigated lung inflammation and resulted in 100% survival in this intranasal mouse model of SEB-mediated shock. Published by Elsevier B.V. C1 [Krakauer, Teresa; Buckley, Marilyn J.] USAMRIID, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. [Huzella, Louis M.; Alves, Derron A.] USA, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. RP Krakauer, T (reprint author), USAMRIID, Integrated Toxicol Div, 1425 Porter St, Ft Detrick, MD 21702 USA. EM teresa.krakauer@amedd.army.mil FU Defense Threat Reduction Agency FX This work was supported by the Defense Threat Reduction Agency. We thank Diana Fisher for statistical analysis. The opinions, interpretations, as well as conclusions represent those of the author and are not necessarily endorsed by the Department of Defense. All authors have no conflict of interest, financial or otherwise, related to the article. NR 39 TC 11 Z9 12 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1567-5769 J9 INT IMMUNOPHARMACOL JI Int. Immunopharmacol. PD SEP PY 2009 VL 9 IS 10 BP 1168 EP 1174 DI 10.1016/j.intimp.2009.06.004 PG 7 WC Immunology; Pharmacology & Pharmacy SC Immunology; Pharmacology & Pharmacy GA 498BT UT WOS:000270111400005 PM 19539058 ER PT J AU Mayo, JB Wetzel, ED Hosur, MV Jeelani, S AF Mayo, Jessie B., Jr. Wetzel, Eric D. Hosur, Mahesh V. Jeelani, Shaik TI Stab and puncture characterization of thermoplastic-impregnated aramid fabrics SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Stab; Cut; Puncture; Thermoplastic; Aramid ID ALL-POLYPROPYLENE COMPOSITES; LOW-VELOCITY IMPACT; ENERGY-ABSORPTION; CUT RESISTANCE; PERFORMANCE; FIBERS; GEOMETRY; WOVEN; SHEET; YARNS AB The cut and puncture resistance of thermoplastic (TP) impregnated, woven aramid fabric is characterized under quasi-static and dynamic stab testing conditions. Polyethylene, Surlyn (R), and co-extruded polyethylene-Surlyn films of various thicknesses are laminated into fabrics and compared with neat fabrics at equal weights and layer counts. The results show that TP-laminated fabrics improve the stab and puncture resistance of the fabrics, through a combination of increased cut resistance and reduced windowing. All films are shown to be effective, although thin Surlyn films appear to provide the best overall performance. The results also show that the TP films need to be integrally bonded to the fabrics in order to achieve synergistic property enhancement. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Mayo, Jessie B., Jr.; Hosur, Mahesh V.; Jeelani, Shaik] Tuskegee Univ, Ctr Adv Mat, Tuskegee, AL 36088 USA. [Wetzel, Eric D.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Hosur, MV (reprint author), Tuskegee Univ, Ctr Adv Mat, 104 James Ctr, Tuskegee, AL 36088 USA. EM mhosur@gmail.com FU Army Research Office (Raleigh, North Carolina); National Science Foundation (NSF-CREST, NSF-IGERT, and NSF-EPSCoR) FX This work has been supported through grants from the Army Research Office (Raleigh, North Carolina), National Science Foundation (NSF-CREST, NSF-IGERT, and NSF-EPSCoR) at Tuskegee University's Center for Advanced Materials Research (TCAM). NR 36 TC 41 Z9 41 U1 5 U2 18 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X EI 1879-3509 J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD SEP PY 2009 VL 36 IS 9 BP 1095 EP 1105 DI 10.1016/j.ijimpeng.2009.03.006 PG 11 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 460FD UT WOS:000267172700002 ER PT J AU Bautista, CT Singer, DE O'Connell, RJ Crum-Cianflone, N Agan, BK Malia, JA Sanchez, JL Peel, SA Michael, NL Scott, PT AF Bautista, C. T. Singer, D. E. O'Connell, R. J. Crum-Cianflone, N. Agan, B. K. Malia, J. A. Sanchez, J. L. Peel, S. A. Michael, N. L. Scott, P. T. TI Herpes simplex virus type 2 and HIV infection among US military personnel: implications for health prevention programmes SO INTERNATIONAL JOURNAL OF STD & AIDS LA English DT Article DE HSV-2; HIV; herpes; co-infection; military; epidemiology; United States ID HUMAN-IMMUNODEFICIENCY-VIRUS; SEXUALLY-TRANSMITTED-DISEASES; GENITAL HERPES; UNITED-STATES; DOUBLE-BLIND; WOMEN; RISK; TRANSMISSION; MEN; VALACYCLOVIR AB US military personnel are routinely screened for HIV infection. Herpes simplex virus type 2 (HSV-2) is a risk factor for HIV acquisition. To determine the association between HSV-2 and HIV, a matched case-control study was conducted among US Army and Air Force servicemembers with incident HIV infections (cases) randomly matched with two HIV-uninfected servicemembers (controls) between 2000 and 2004. HSV-2 prevalence was significantly higher among cases (30.3%, 138/456) than among controls (9.7%, 88/912, P < 0.001). HSV-2 was strongly associated with HIV in univariate (odds ratio [OR] = 4.2, 95% confidence interval [CI] = 3.1-5.8) and multiple analyses (adjusted [OR] = 3.9, 95% CI = 2.8-5.6). The population attributable risk percentage of HIV infection due to HSV-2 was 23%. Identifying HSV-2 infections may afford the opportunity to provide targeted behavioural interventions that could decrease the incidence of HIV infections in the US military population; further studies are needed. C1 [Bautista, C. T.; Singer, D. E.; O'Connell, R. J.; Malia, J. A.; Peel, S. A.; Michael, N. L.; Scott, P. T.] Walter Reed Army Inst Res, US Mil HIV Res Program, Div Retrovirol, Rockville, MD 20850 USA. [O'Connell, R. J.; Crum-Cianflone, N.; Agan, B. K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Crum-Cianflone, N.] USN, HIV Clin, Med Ctr, San Diego, CA 92152 USA. [Sanchez, J. L.] Walter Reed Army Inst Res, DoD Global Emerging Infect Surveillance & Respons, Rockville, MD 20850 USA. RP Bautista, CT (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Div Retrovirol, 1 Taft Court,Suite 250, Rockville, MD 20850 USA. EM cbautista@hivresearch.org RI Bautista, Christian/B-2812-2011; OI Agan, Brian/0000-0002-5114-1669 FU Walter Reed Army Institute of Research FX Data were presented at the Fourth International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention, abstract MOAC101, Sydney, 2007. NR 27 TC 7 Z9 9 U1 0 U2 1 PU ROYAL SOC MEDICINE PRESS LTD PI LONDON PA 1 WIMPOLE STREET, LONDON W1G 0AE, ENGLAND SN 0956-4624 J9 INT J STD AIDS JI Int. J. STD AIDS PD SEP PY 2009 VL 20 IS 9 BP 634 EP 637 DI 10.1258/ijsa.2008.008413 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 496VT UT WOS:000270008500009 PM 19710337 ER PT J AU Ehrich, M Wu, XH Werre, SR Major, MA McCain, WC Reddy, G AF Ehrich, Marion Wu, Xiaohua Werre, Stephen R. Major, Michael A. McCain, Wilfred C. Reddy, Gunda TI Calcium Signaling in Neuronal Cells Exposed to the Munitions Compound Cyclotrimethylenetrinitramine (RDX) SO INTERNATIONAL JOURNAL OF TOXICOLOGY LA English DT Article DE calcium; carbachol; human neuroblastoma cells; RDX; SH-SY5Y cells ID HUMAN NEUROBLASTOMA-CELLS; INTRACELLULAR CALCIUM; INDUCED APOPTOSIS; SH-SY5Y CELLS; RAT-BRAIN; IN-VITRO; ACID; BIOAVAILABILITY; ACTIVATION; EXPRESSION AB Cyclotrimethylenetrinitramine (RDX) has been used extensively as an explosive in military munitions. Mechanisms for seizure production, seen in past animal studies, have not been described. Increased calcium levels contribute to excitotoxicity, so in this study neuroblastoma cells are loaded with calcium-indicating dye before application of 1.5 mu M to 7.5 mM RDX, with fluorescence recorded for 30 cycles of 11 seconds each. The lowest concentration of RDX increases calcium fluorescence significantly above baseline for cycles 2 to 8; millimolar concentrations increase calcium fluorescence significantly above baseline for cycles 2 to 30. Increases in calcium, like those of 200 nM carbachol, are prevented with 10 mM of calcium chelator ethylene glycol-bis(beta-aminoethyl ether)-N,N,N,N tetra-acetic acid ( EGTA, tetrasodium salt). Calcium channel blocker verapamil (20 mu M), Ca(2+)-ATPase inhibitor thapsigargin (5 mu M), and general membrane stabilizer lidocaine (10 mM) partially attenuate carbachol- and RDX-induced increases in calcium, suggesting that RDX transiently increases intracellular calcium by multiple mechanisms. C1 [Ehrich, Marion] Virginia Tech, Virginia Maryland Reg Coll Vet Med, Blacksburg, VA 24061 USA. [Major, Michael A.; McCain, Wilfred C.; Reddy, Gunda] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD USA. RP Ehrich, M (reprint author), Virginia Tech, Virginia Maryland Reg Coll Vet Med, 1 Duck Pond Dr, Blacksburg, VA 24061 USA. EM marion@vt.edu FU Directorate of Toxicology; US Army Center for Health Promotion and Preventive Medicine FX Funding for this research was from the Directorate of Toxicology, US Army Center for Health Promotion and Preventive Medicine, Aberdeen Proving Ground. We thank Drs D. Bannon and C. Cao for critical review of the manuscript, and Dr L. Li for use of his laboratory. NR 33 TC 3 Z9 3 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1091-5818 J9 INT J TOXICOL JI Int. J. Toxicol. PD SEP PY 2009 VL 28 IS 5 BP 425 EP 435 DI 10.1177/1091581809340331 PG 11 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 504RU UT WOS:000270635800009 PM 19652196 ER PT J AU Conti, ML Che, MM Boylan, M Sciuto, AM Gordon, RK Nambiar, MP AF Conti, Michele L. Che, Magnus M. Boylan, Megan Sciuto, Alfred M. Gordon, Richard K. Nambiar, Madhusoodana P. TI Acute Microinstillation Inhalation Exposure to Sarin Induces Changes in Respiratory Dynamics and Functions in Guinea Pigs SO INTERNATIONAL JOURNAL OF TOXICOLOGY LA English DT Article DE acetylcholinesterase; organophosphates; chemical warfare agents; microinstillation; respiratory system; pulmonary injury; barometric plethysmography ID WHOLE-BODY PLETHYSMOGRAPHY; NERVE AGENT VX; ACETYLCHOLINESTERASE ACTIVITY; TISSUE CHOLINESTERASE; ANTIDOTAL TREATMENT; SOMAN; TOXICITY; RATS; CARBOXYLESTERASE; PROTECTION AB This study investigates the toxic effects of sarin on respiratory dynamics following microinstillation inhalation exposure in guinea pigs. Animals are exposed to sarin for 4 minutes, and respiratory functions are monitored at 4 hours and 24 hours by whole-body barometric plethysmography. Data show significant changes in respiratory dynamics and function following sarin exposure. An increase in respiratory frequency is observed at 4 hours post exposure compared with saline controls. Tidal volume and minute volume are also increased in sarin-exposed animals 4 hours after exposure. Peak inspiratory flow increases, whereas peak expiratory flow increases at 4 hours and is erratic following sarin exposure. Animals exposed to sarin show a significant decrease in expiratory time and inspiratory time. End-inspiratory pause is unchanged whereas end-expiratory pause is slightly decreased 24 hours after sarin exposure. These results indicate that inhalation exposure to sarin alters respiratory dynamics and function at 4 hours, with return to normal levels at 24 hours post exposure. C1 [Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Dept Closed Head Injury, Brain Dysfunct & Blast Injury Div, Silver Spring, MD 20910 USA. [Conti, Michele L.; Boylan, Megan; Sciuto, Alfred M.] USA, Med Res Inst Chem Def, Edgewood, MD USA. [Nambiar, Madhusoodana P.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Nambiar, MP (reprint author), Walter Reed Army Inst Res, Dept Closed Head Injury, Brain Dysfunct & Blast Injury Div, Silver Spring, MD 20910 USA. EM Madhusoodana.nambiar@amedd.army.mil FU National Institutes of Environmental Health Sciences/National Institutes of Health [5U01ES015677] FX The project described was supported by grant 5U01ES015677 from the National Institutes of Environmental Health Sciences/National Institutes of Health and managed by the Geneva Foundation, Lakewood, WA. Its contents, opinions and assertions contained herein are private views of the authors are not to be construed as official or reflecting the views of the National Institutes of Environmental Health Sciences/National Institutes of Health, Department of the Army or the Department of Defense. NR 47 TC 7 Z9 7 U1 0 U2 2 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1091-5818 J9 INT J TOXICOL JI Int. J. Toxicol. PD SEP PY 2009 VL 28 IS 5 BP 436 EP 447 DI 10.1177/1091581809344879 PG 12 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 504RU UT WOS:000270635800010 PM 19815847 ER PT J AU Loro, WA Owens, B AF Loro, William A. Owens, Brett TI Unilateral Hypoglossal Nerve Injury in a Collegiate Wrestler: A Case Report SO JOURNAL OF ATHLETIC TRAINING LA English DT Article DE twelfth cranial nerve; tongue paralysis; dysarthria; dysphagia ID OF-THE-LITERATURE; OCCIPITAL CONDYLE; PALSY; SYRINGOMYELIA; FRACTURE; TONGUE AB Objective: To introduce the case of a collegiate wrestler who suffered a traumatic unilateral hypoglossal nerve injury. This case presents the opportunity to discuss the diagnosis and treatment of a 20-year-old man with an injury to his right hypoglossal nerve. Background: Injuries to the hypoglossal nerve (cranial nerve XII) are rare. Most reported cases are the result of malignancy, with traumatic causes less common. In this case, a collegiate wrestler struck his head on the wrestling mat during practice. No loss of consciousness occurred. The wrestler initially demonstrated signs and symptoms of a mild concussion, with dizziness and a headache. These concussion symptoms cleared quickly, but the athlete complained of difficulty swallowing (dysphagia) and demonstrated slurred speech (dysarthria). Also, his tongue deviated toward the right. No other neurologic deficits were observed. Differential Diagnosis: Occipital-cervical junction fracture, syringomyelia, malignancy, iatrogenic causes, cranial nerve injury. Treatment: After initial injury recognition, the athletic trainer placed the patient in a cervical collar and transported him to the emergency department. The patient received prednisone, and the emergency medicine physician ordered cervical spine plain radiographs, brain computed tomography, and brain and internal auditory canal magnetic resonance imaging. The physician consulted a neurologist, who managed the patient conservatively, with rest and no contact activity. The neurologist allowed the patient to participate in wrestling 7 months after injury. Uniqueness: To our knowledge, no other reports of unilateral hypoglossal nerve injury from relatively low-energy trauma (including athletics) exist. Conclusions: Hypoglossal nerve injury should be considered in individuals with head injury who experience dysphagia and dysarthria. Athletes with head injuries require cranial nerve assessments. C1 [Loro, William A.] US Army, Med Dept Ctr & Sch, Ft Sam Houston, TX 78234 USA. [Owens, Brett] William Beaumont Army Med Ctr, El Paso, TX 79920 USA. RP Loro, WA (reprint author), US Army, Med Dept Ctr & Sch, 3151 Scott Rd,Suite 1303, Ft Sam Houston, TX 78234 USA. EM william.loro@us.army.mil NR 17 TC 4 Z9 4 U1 0 U2 0 PU NATL ATHLETIC TRAINERS ASSOC INC PI DALLAS PA 2952 STEMMONS FREEWAY, DALLAS, TX 75247 USA SN 1062-6050 J9 J ATHL TRAINING JI J. Athl. Train. PD SEP-OCT PY 2009 VL 44 IS 5 BP 534 EP 537 DI 10.4085/1062-6050-44.5.534 PG 4 WC Sport Sciences SC Sport Sciences GA 499SP UT WOS:000270246100014 PM 19771294 ER PT J AU Endorf, FW Cancio, LC Klein, MB AF Endorf, Frederick W. Cancio, Leopoldo C. Klein, Matthew B. TI Necrotizing Soft-Tissue Infections: Clinical Guidelines SO JOURNAL OF BURN CARE & RESEARCH LA English DT Editorial Material ID HYPERBARIC-OXYGEN THERAPY; AGGRESSIVE SURGICAL-MANAGEMENT; FASCIITIS REDUCES MORTALITY; A STREPTOCOCCAL INFECTIONS; VACUUM-ASSISTED CLOSURE; BURN CENTER MANAGEMENT; DECREASE MORTALITY; OBSTETRIC PATIENTS; IMMUNOGLOBULIN; SKIN C1 [Endorf, Frederick W.] Reg Hosp, Burn Ctr, St Paul, MN 55101 USA. [Cancio, Leopoldo C.] USA, Inst Surg Res, San Antonio, TX USA. [Klein, Matthew B.] Univ Washington, Harborview Med Ctr, Seattle, WA 98104 USA. RP Endorf, FW (reprint author), Reg Hosp, Burn Ctr, 640 Jackson St, St Paul, MN 55101 USA. NR 43 TC 8 Z9 9 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X EI 1559-0488 J9 J BURN CARE RES JI J. Burn Care Res. PD SEP-OCT PY 2009 VL 30 IS 5 BP 769 EP 775 DI 10.1097/BCR.0b013e3181b48321 PG 7 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA 494YP UT WOS:000269856100002 PM 19692912 ER PT J AU Taylor, AJ Wu, H Bindeman, J Bauer, K Byrd, C O'Malley, PG Feuerstein, I AF Taylor, Allen J. Wu, Holly Bindeman, Jody Bauer, Kelly Byrd, Carole O'Malley, Patrick G. Feuerstein, Irwin TI The Relationship Between the Cardiometabolic Syndrome and Coronary Artery Calcium Progression SO JOURNAL OF CLINICAL HYPERTENSION LA English DT Article ID BEAM COMPUTED-TOMOGRAPHY; METABOLIC SYNDROME; MYOCARDIAL-INFARCTION; PROVISIONAL REPORT; DIABETES-MELLITUS; RISK-FACTORS; CONSULTATION; CHOLESTEROL; DEFINITION; DIAGNOSIS AB Cardiometabolic syndrome has been associated with increased likelihood and extent of coronary artery calcium (CAC). The authors examined the relationship of cardiometabolic syndrome to CAC progression in 200 healthy men who volunteered to undergo repeated electron beam tomography separated by 4.2 +/- 1.3 years. Prediction of clinically significant CAC progression (>= 15% per year) was evaluated using multivariable logistic regression models and principal component analysis. Clinically significant CAC progression was observed in 52.5% of the cohort, with the mean and median rate of annual progression 41.3% and 18.3%, respectively. The cardiometabolic syndrome in clinically significant CAC progression participants was significantly higher compared with those without CAC progression (24.8% vs 11.6%; P=.016). Cardiometabolic syndrome was a significant independent predictor of clinically significant CAC progression (odds ratio, 2.65; P=.022). Cardiometabolic syndrome is associated with the baseline CAC score, and independently associated with the progression of CAC over 4 years. C1 Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Taylor, AJ (reprint author), Washington Hosp Ctr, Serv Cardiol, 110 Irving St NW, Washington, DC 20010 USA. EM allen.taylor@medstar.net FU [ERMS 00239017-00216] FX The opinions or assertions herein are the private views of the authors and are not to be construed as reflecting the views of the Department of the Army or the Department of Defense. Supported by the Congressionally-directed, Peer Reviewed Medical Research Program, grant number ERMS 00239017-00216. NR 19 TC 3 Z9 3 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1524-6175 J9 J CLIN HYPERTENS JI J. Clin. Hypertens. PD SEP PY 2009 VL 11 IS 9 BP 505 EP 511 DI 10.1111/j.1559-4572.2009.00059.x PG 7 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 492ZQ UT WOS:000269702600008 PM 19751466 ER PT J AU Mahlen, SD Clarridge, JE AF Mahlen, Steven D. Clarridge, Jill E., III TI Thumb Infection Caused by Streptococcus pseudoporcinus SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID PORCINUS; IDENTIFICATION AB Streptococcus pseudoporcinus, a recently described organism found in the genitourinary tract of women, was isolated from a thumb wound in a male patient subsequent to trauma. This case describes a rarely reported non-genitourinary tract clinical isolate of S. pseudoporcinus. C1 [Mahlen, Steven D.] Univ Washington, Dept Lab Med, USA, Seattle, WA 98195 USA. [Clarridge, Jill E., III] VA Puget Sound Hlth Care Syst, Pathol & Lab Med Serv, Seattle, WA 98108 USA. RP Clarridge, JE (reprint author), VA Puget Sound Hlth Care Syst, Pathol & Lab Med Serv 113, 1660 S Columbian Way, Seattle, WA 98108 USA. EM Jill.clarridge@va.gov NR 14 TC 2 Z9 2 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD SEP PY 2009 VL 47 IS 9 BP 3041 EP 3042 DI 10.1128/JCM.00802-09 PG 2 WC Microbiology SC Microbiology GA 489RL UT WOS:000269439600062 PM 19571017 ER PT J AU Waters, JP Easley, DH Noakes, SE Penland, S AF Waters, Jeffrey P. Easley, Dale H. Noakes, Scott E. Penland, Shea TI Geochemistry of Surficial Sediments from Lake Pontchartrain Resulting from the 1997 Opening of the Bonnet Carre Spillway SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE Major cations; aluminum; silicon; potassium; calcium; iron; magnesium; sulfur; geostatistics; variogram; river diversion AB The Bonnet Carre Spillway is a flood-control structure that diverts Mississippi River water into Lake Pontchartrain during exceptionally high river stages. Because of elevated water levels in the Mississippi River in the spring of 1997, the Bonnet Carre Spillway was opened on March 17 and fully closed on April 18. The total volume of water discharged into Lake Pontchartrain was approximately 11.8 km(3), or two times the volume of the lake, and the total mass of sediment discharged into the lake was approximately 7.1 x 10(8) kg (780,000 US tons). In 1996, 757 surface sediment samples were collected in Lake Pontchartrain and were analyzed by x-ray fluorescence spectroscopy for major cation constituents. These same sites were revisited following the 1997 Mississippi River discharge event. Analysis of the 1996 and 1997 lake-bed sediment samples was accomplished utilizing fundamental statistical and graphical methods. Element concentration contour maps and variograms for the major cations illustrate meaningful differences between the pre- and postspillway sediment samples that are not readily apparent in the analysis of the descriptive statistics alone. Major cations exhibited significantly greater spatial continuity in the postspillway samples relative to the preceding year. The concentrations of aluminum and silicon in the postspillway sediments are considered to reflect, respectively, relative variations in clay and silt contribution to total sediment. The higher concentrations of magnesium in samples collected prior to the river diversion represent adsorption of magnesium onto exchange sites in surface sediments due to exposure to more saline waters. C1 [Waters, Jeffrey P.] US Army Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. [Easley, Dale H.] Univ Dubuque, Dept Nat & Appl Sci, Dubuque, IA 52001 USA. [Noakes, Scott E.] Univ Georgia, Ctr Appl Isotope Studies, Athens, GA 30602 USA. [Penland, Shea] Pontchartrain Inst Environm Sci, Orleans, LA 70122 USA. RP Waters, JP (reprint author), US Army Engineer Res & Dev Ctr, Coastal & Hydraul Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Jeffrey.p.waters@usace.army.mil FU U. S. Geological Survey; Lake Pontchartrain Basin Foundation FX The authors would like to thank the U. S. Geological Survey and the Lake Pontchartrain Basin Foundation for providing the funding for the sediment sampling and analyses. NR 23 TC 1 Z9 1 U1 4 U2 4 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 EI 1551-5036 J9 J COASTAL RES JI J. Coast. Res. PD FAL PY 2009 SI 54 BP 127 EP 140 DI 10.2112/SI54-010.1 PG 14 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA V39ZD UT WOS:000209448000013 ER PT J AU Chun, CKS AF Chun, Clayton K. S. TI The Development of Precision Guided Munitions SO JOURNAL OF COLD WAR STUDIES LA English DT Book Review C1 [Chun, Clayton K. S.] USA, War Coll, Washington, DC 20310 USA. RP Chun, CKS (reprint author), USA, War Coll, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU MIT PRESS PI CAMBRIDGE PA 55 HAYWARD STREET, CAMBRIDGE, MA 02142 USA SN 1520-3972 J9 J COLD WAR STUD JI J. Cold War Stud. PD FAL PY 2009 VL 11 IS 4 BP 160 EP 162 DI 10.1162/jcws.2009.11.4.160 PG 3 WC History; International Relations; Political Science SC History; International Relations; Government & Law GA V25DN UT WOS:000208458800015 ER PT J AU OBrien, SD Bui-Mansfield, LT AF OBrien, Seth D. Bui-Mansfield, Liem T. TI Costovertebral Fracture Dislocations: Important Radiographically Difficult Diagnosis SO JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY LA English DT Article DE spine; costovertebral joint; fracture; dislocation; computed tomography; radiography; diagnosis ID THORACIC SPINE; RIB CAGE; STABILITY; TRAUMA AB The authors' aim is to report the appearance of fracture dislocations of the costovertebral joint. We will review the pertinent anatomy of the costovertebral articulation, summarize the current literature, report our experience and the imaging appearance of costovertebral joint fracture dislocations, and discuss important concepts of the costovertebral joint, as it relates to thoracic spine fractures. C1 [OBrien, Seth D.; Bui-Mansfield, Liem T.] Brooke Army Med Ctr, Dept Radiol, SAUSHEC, San Antonio, TX USA. [Bui-Mansfield, Liem T.] Wake Forest Univ, Dept Radiol, Winston Salem, NC 27109 USA. [Bui-Mansfield, Liem T.] USUHS, Dept Radiol, Bethesda, MD USA. RP Bui-Mansfield, LT (reprint author), 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM liem.mansfield@gmail.com NR 10 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0363-8715 J9 J COMPUT ASSIST TOMO JI J. Comput. Assist. Tomogr. PD SEP-OCT PY 2009 VL 33 IS 5 BP 748 EP 751 PG 4 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 508HH UT WOS:000270920600019 PM 19820505 ER PT J AU White, WG AF White, William G. TI MORTARS AND ROCKETS SO JOURNAL OF EMERGENCY NURSING LA English DT Article C1 [White, William G.] USA, Army Nurse Corps, San Antonio, TX USA. [White, William G.] Def Med Readiness Training Inst, San Antonio, TX USA. RP White, WG (reprint author), 1706 Stanley Rd,Bldg 2263, San Antonio, TX 78234 USA. EM Clutter@wildblue.net NR 0 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0099-1767 J9 J EMERG NURS JI J. Emerg. Nurs. PD SEP PY 2009 VL 35 IS 5 BP 465 EP 468 DI 10.1016/j.jen.2009.05.015 PG 4 WC Emergency Medicine; Nursing SC Emergency Medicine; Nursing GA 506GS UT WOS:000270763500021 PM 19748034 ER PT J AU Norris, WE Perry, JL Moawad, FJ Horwhat, JD AF Norris, William E. Perry, Joseph L. Moawad, Fouad J. Horwhat, J. David TI An Unusual Presentation of Metastatic Esophageal Adenocarcinoma Presenting as Thigh Pain SO JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES LA English DT Article DE Esophageal adenocarcinoma; skeletal muscle metastasis; iliacus muscle metastasis; intra-pelvis mass; thigh pain ID SKELETAL-MUSCLE METASTASES; GASTRIC CARDIA; UNITED-STATES; INTESTINAL METAPLASIA; RISING INCIDENCE; CARCINOMA; CANCER; RISK AB The association between esophageal adenocarcinoma and distant skeletal muscle metastasis is extremely rare. Only three cases have been previously reported in the literature. All reported involvement of the gastroesophageal junction. We describe a 58 year-old Caucasian man who presented with worsening right hip pain for nine months. Computerized axial tomography (CT) scan demonstrated a 10 cm by 8 cm by 12 cm intra-pelvic mass involving the right iliacus muscle with central destruction of the right mid-ileum. CT-guided biopsy of the right hip mass demonstrated poorly differentiated carcinoma. CT scan of the chest revealed a 5 cm by 4 cm circumferential mass involving the distal esophagus. Endoscopic biopsy showed poorly differentiated adenocarcinoma. Immunohistochemical analysis of each specimen correlated for pancytokeratin. Final diagnosis was primary esophageal adenocarcinoma with distant metastasis to the right ileum and iliacus muscle. We review distinctions between esophageal adenocarcinoma and adenocarcinoma of the gastroesophageal junction. A brief discussion of diagnostic modalities and treatment options are provided. C1 [Norris, William E.; Perry, Joseph L.; Moawad, Fouad J.; Horwhat, J. David] Walter Reed Army Med Ctr, Dept Med, Gastroenterol Serv, Washington, DC 20307 USA. RP Norris, WE (reprint author), Walter Reed Army Med Ctr, Dept Med, Gastroenterol Serv, Washington, DC 20307 USA. EM William.Norris@amedd.army.mil NR 31 TC 5 Z9 5 U1 0 U2 0 PU MEDICAL UNIV PRESS PI CLUJ-NAPOCA PA 3RD MEDICAL CLINIC, STR CROITORILOR NO 19-21, CLUJ-NAPOCA, 400162, ROMANIA SN 1841-8724 J9 J GASTROINTEST LIVER JI J. Gastrointest. Liver Dis. PD SEP PY 2009 VL 18 IS 3 BP 371 EP 374 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 631BC UT WOS:000280320500019 PM 19795036 ER PT J AU Jeyaraj, A Balser, DB Chowa, C Griggs, GM AF Jeyaraj, Anand Balser, Deborah B. Chowa, Charles Griggs, Gary M. TI Organizational and institutional determinants of B2C adoption under shifting environments SO JOURNAL OF INFORMATION TECHNOLOGY LA English DT Article; Proceedings Paper CT 65th Annual Meeting of the Academy-of-Management/Academy-of-International-Business Conference CY AUG 05-10, 2005 CL Honolulu, HI SP Acad Management, Acad Int Business DE B2C; business-to-consumer; e-commerce; innovation; adoption; institutional theory; espoused values; resources; environment; longitudinal data; event-history analysis ID ELECTRONIC DATA INTERCHANGE; INFORMATION-SYSTEMS INNOVATION; EDI ADOPTION; E-BUSINESS; EMPIRICAL-TEST; E-COMMERCE; DIFFUSION; INTEGRATION; TECHNOLOGY; INDUSTRY AB This study examines the adoption of business-to-consumer (B2C) e-commerce by bricks-and-mortar companies comprising the Standard & Poor's 500 (S&P 500) listings between 1992 and 2003. B2C represents a Type III information systems (IS) innovation that integrates IS with core business technologies. Extant studies on Type III innovations have examined organizational and institutional factors, solely or collectively, in explaining adoption, but not how their effects change under shifting environments over time. We develop an integrated model comprising organizational factors (i.e., espoused values and resources) and institutional factors (i.e., normative and mimetic pressures), as well as the moderating influence of shifting environments (i.e., early period and late period demarcated by changes in the environment). Using a piecewise event-history model specification, we examine the adoption of B2C innovations by 93 organizations over time. Our results show that both organizational and institutional factors influence B2C adoption; however, their effects varied with the environmental shifts. Specifically, senior IS executives influenced adoption in the early period whereas bandwagon mimetic pressures and business norms influenced adoption in the late period. The findings of our research demonstrate the importance of explicitly modeling environmental shifts in theorizing organizational adoption of innovations. Journal of Information Technology (2009) 24, 219-230. doi:10.1057/jit.2008.22 Published online 2 December 2008. C1 [Jeyaraj, Anand] Wright State Univ, Raj Soin Coll Business, Dayton, OH 45435 USA. [Balser, Deborah B.] Univ Missouri, Coll Business Adm, St Louis, MO 63121 USA. [Chowa, Charles] Univ N Carolina, Bryan Sch Business, Greensboro, NC 27412 USA. [Griggs, Gary M.] US Mil Acad, West Point, NY 10996 USA. RP Jeyaraj, A (reprint author), Wright State Univ, Raj Soin Coll Business, 3640 Colonel Glenn Highway, Dayton, OH 45435 USA. EM anand.jeyaraj@wright.edu NR 62 TC 2 Z9 3 U1 3 U2 21 PU PALGRAVE MACMILLAN LTD PI BASINGSTOKE PA BRUNEL RD BLDG, HOUNDMILLS, BASINGSTOKE RG21 6XS, HANTS, ENGLAND SN 0268-3962 J9 J INF TECHNOL JI J. Inf. Technol. PD SEP PY 2009 VL 24 IS 3 BP 219 EP 230 DI 10.1057/jit.2008.22 PG 12 WC Computer Science, Information Systems; Information Science & Library Science; Management SC Computer Science; Information Science & Library Science; Business & Economics GA 485UP UT WOS:000269150600003 ER PT J AU Rushing, JF Newman, K AF Rushing, John F. Newman, Kent TI Full-Scale Testing of Chemical Dust Palliatives in a Semicontrolled Environment SO JOURNAL OF MATERIALS IN CIVIL ENGINEERING LA English DT Article AB Two commercially available chemical dust palliatives were evaluated in full-scale experiments in an enclosed, controlled environment to evaluate their effectiveness and to determine impacts to a stabilized surface. The dust palliatives were topically applied at multiple application rates to the surface of a silty sand soil that had been stabilized using a combination of Portland cement and polypropylene monofilament fibers. Simulated traffic was applied to enclosed test sections using the heavy vehicle simulator-aircraft fitted with a C-17 aircraft tire at 15,560 kg (34,300 lb) load. The effectiveness of the dust palliatives was quantitatively measured using both gravimetric and optical detection devices. Results from the experiment show nearly complete reduction in dust for Palliative 2 (a synthetic oil) and heavy applications of Palliative 1 (an emulsion polymer). The methodology used for experimentally determining the dust palliative effectiveness provided a mechanism for reducing environmental influences that often invalidate and confuse the results of field experimentation data. C1 [Rushing, John F.; Newman, Kent] USA, Airfields & Pavements Branch, Engn Res & Dev Ctr, Vicksburg, MS USA. RP Rushing, JF (reprint author), USA, Airfields & Pavements Branch, Engn Res & Dev Ctr, Vicksburg, MS USA. EM john.f.rushing@usace.army.mil; john.k.newman@usace.army.mil NR 7 TC 0 Z9 0 U1 1 U2 4 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0899-1561 J9 J MATER CIVIL ENG JI J. Mater. Civ. Eng. PD SEP PY 2009 VL 21 IS 9 BP 454 EP 459 DI 10.1061/(ASCE)0899-1561(2009)21:9(454) PG 6 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA 484QO UT WOS:000269062100003 ER PT J AU McCarthy, M Waits, CM Beyaz, MI Ghodssi, R AF McCarthy, Matthew Waits, C. Mike Beyaz, Mustafa I. Ghodssi, Reza TI A rotary microactuator supported on encapsulated microball bearings using an electro-pneumatic thrust balance SO JOURNAL OF MICROMECHANICS AND MICROENGINEERING LA English DT Article; Proceedings Paper CT 8th International Workshop on Micro and Nanotechnology for Power Generation and Energy Conversion Applications CY NOV 09-12, 2008 CL Tohoku Univ, Sendai, JAPAN HO Tohoku Univ ID FABRICATION; DESIGN AB The development of a rotary microactuator supported on encapsulated microball bearings and driven by electro-pneumatic actuation is reported. The encapsulated bearing provides full support to an encased rotor, while an electro-pneumatic thrust balance is used to minimize rotor normal load. By minimizing normal load, bearing friction is reduced leading to increased speed and performance. Experimental results show that the microactuator is capable of repeatable operation and continuous 360 degrees motion at speeds of 5-2000 rpm. This is the first demonstration of a ball bearing supported electrostatic microactuator with a fully encased rotor, capable of direct mechanical attachment or reliable interaction with external media. C1 [Beyaz, Mustafa I.; Ghodssi, Reza] Univ Maryland, MEMS Sensors & Actuators Lab, Dept Elect & Comp Engn, Syst Res Inst, College Pk, MD 20742 USA. [McCarthy, Matthew] MIT, Dept Mech Engn, Cambridge, MA 02139 USA. [Waits, C. Mike] USA, Res Lab, Adelphi, MD 20783 USA. RP Ghodssi, R (reprint author), Univ Maryland, MEMS Sensors & Actuators Lab, Dept Elect & Comp Engn, Syst Res Inst, College Pk, MD 20742 USA. EM ghodssi@umd.edu NR 17 TC 7 Z9 7 U1 0 U2 9 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND SN 0960-1317 J9 J MICROMECH MICROENG JI J. Micromech. Microeng. PD SEP PY 2009 VL 19 IS 9 AR 094007 DI 10.1088/0960-1317/19/9/094007 PG 7 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA 490CJ UT WOS:000269474500008 ER PT J AU Hartman, LJ Selby, EB Whitehouse, CA Coyne, SR Jaissle, JG Twenhafel, NA Burke, RL Kulesh, DA AF Hartman, Laurie J. Selby, Edward B. Whitehouse, Chris A. Coyne, Susan R. Jaissle, James G. Twenhafel, Nancy A. Burke, Robin L. Kulesh, David A. TI Rapid Real-Time PCR Assays for Detection of Klebsiella pneumoniae with the rmpA or magA Genes Associated with the Hypermucoviscosity Phenotype Screening of Nonhuman Primates SO JOURNAL OF MOLECULAR DIAGNOSTICS LA English DT Article ID PYOGENIC LIVER-ABSCESS; POSITIVE CONTROL; VIRULENCE GENE; OLIGONUCLEOTIDES; COMPLICATIONS; BACTEREMIA; PATHOGEN; TAIWAN; K1 AB The relationship of mucoviscosity-associated (magA) and/or regulator of mucoid phenotype (rmpA) genes to the Klebsiella pneumoniae hypermucoviscosity (HMV) phenotype has been reported. We previously demonstrated that rmpA + K. pneumoniae can cause serious disease in African green monkeys and isolated rmpA + and magA + HMV K. pneumoniae from other species of non-human primates. To rapidly screen African green monkeys/non-human primates for these infections, we developed three real-time PCR assays. The first was K. pneumoniae-specific, targeting the khe gene, while the others targeted rmpA and magA. Primer Express 2 was used with the three K. pneumoniae genes to generate sequence-specific Taq-Man/TaqMan-Minor Groove Binder assays. Oral/rectal swabs and necropsy samples were collected; swabs were used for routine culture and DNA extraction. K. pneumoniae colonies were identified on the Vitek 2 with DNA tested using the K. pneumoniae-specific assays. Testing of 45 African green monkeys resulted in 19 khe+ samples from 14 animals with none positive for either rmpA or magA. Of these 19 khe + samples, five were culture-positive, but none were HMV "string test"-positive. Subsequent testing of 307 non-human primates resulted in 64 HMV K. pneumoniae isolates of which 42 were rmpA + and 15 were magA +. Non-human primate testing at the U.S. Army Medical Research institute of Infectious Diseases demonstrated the ability to screen both live and necropsied animals for K. pneumoniae by culture and real-time PCR to determine HMV genotype. (J Mol Diagn 2009,11:464-471; DOI: 10.2353/jmoldx.2009.080136) C1 [Hartman, Laurie J.; Selby, Edward B.; Whitehouse, Chris A.; Coyne, Susan R.; Jaissle, James G.; Kulesh, David A.] USA, Med Res Inst Infect Dis, Diagnost Syst Div, Frederick, MD USA. RP Kulesh, DA (reprint author), 1425 Porter St, Frederick, MD 21702 USA. EM david.kulesh@amedd.army.mil FU DTRA [8.10030_07_RD_B] FX Supported by DTRA Project # 8.10030_07_RD_B. NR 24 TC 21 Z9 23 U1 1 U2 8 PU AMER SOC INVESTIGATIVE PATHOLOGY, INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3993 USA SN 1525-1578 J9 J MOL DIAGN JI J. Mol. Diagn. PD SEP PY 2009 VL 11 IS 5 BP 464 EP 471 DI 10.2353/jmoldx.2009.080136 PG 8 WC Pathology SC Pathology GA 489OD UT WOS:000269429000013 PM 19644019 ER PT J AU Zottola, MA AF Zottola, Mark A. TI A partial exploration of the potential energy surfaces of SCN and HSCN: Implications for the enzyme-mediated detoxification of cyanide SO JOURNAL OF MOLECULAR GRAPHICS & MODELLING LA English DT Article DE Cyanide; Cyanide detoxification; Rhodanese; Potential energy surface; Thiocyanate; Quantum mechanics ID THERMOCHEMICAL KINETICS; SULFUR AB Cyanide (CN) is considered to be a terrorist chemical weapon due to its ready availability in multi-kilogram quantities and multi-modal means of intoxication. The body uses the sulfur transferase enzyme rhodanese to detoxify cyanide via conversion of cyanide to thiocyanate. This paper explores the potential energy surfaces for the conversion of cyanide anion and hydrogen cyanide to thiocyanate anion and thiocyanic acid, respectively. The potential energy surface for the conversion of cyanide anion to thiocyanate shows that the formation of thiocyanate (SCN) is vastly preferred to formation of its isomer SNC. However, the potential energy surface for the conversion of hydrogen cyanide to thiocyanic acid reveals that the formation of HSCN and HNCS would be relatively equal. The failure for analytical methods to detect HNCS is rationalized by the observation that deprotonation of either HNCS or HSCN leads to the same thiocyanate anion. (C) 2009 Elsevier Inc. All rights reserved. C1 [Zottola, Mark A.] USA, Med Res Inst Chem Def, Edgewood, MD 21010 USA. [Zottola, Mark A.] Univ Alabama, Dept Chem, Birmingham, AL 35294 USA. RP Zottola, MA (reprint author), USA, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Edgewood, MD 21010 USA. EM Mark.Zottola@us.army.mil FU National Institutes of Health and the Department of Defense (NIAID/USAMRICD) [Y1-A1-6176-01, A120-B.P2006-01] FX The authors would like to thank Dr. Roger Klein for helpful discussions. MAZ would also like to acknowledge the Alabama Supercomputer Center for computational resources. We gratefully acknowledge funding from the National Institutes of Health and the Department of Defense (NIAID/USAMRICD Interagency agreement Y1-A1-6176-01 and A120-B.P2006-01). The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the National Institutes of Health, Department of the Army, or the Department of Defense. NR 29 TC 2 Z9 2 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1093-3263 J9 J MOL GRAPH MODEL JI J. Mol. Graph. PD SEP PY 2009 VL 28 IS 2 BP 183 EP 186 DI 10.1016/j.jmgm.2009.06.005 PG 4 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Computer Science, Interdisciplinary Applications; Crystallography; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Computer Science; Crystallography; Mathematical & Computational Biology GA 513UK UT WOS:000271349100012 PM 19625201 ER PT J AU Greathouse, DG Root, TM Carrillo, CR Jordan, CL Pickens, BB Sutlive, TG Shaffer, SW Moore, JH AF Greathouse, David G. Root, Tiffany M. Carrillo, Carla R. Jordan, Chelsea L. Pickens, Bryan B. Sutlive, Thomas G. Shaffer, Scott W. Moore, Josef H. TI Clinical and Electrodiagnostic Abnormalities of the Median Nerve in Dental Assistants SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE carpal tunnel syndrome; hand; nerve conduction study; ulnar nerve ID CARPAL-TUNNEL-SYNDROME; ULNAR NEUROPATHIES; DIAGNOSTIC UTILITY; GENERAL-POPULATION; PRACTICE PARAMETER; SENSORY LATENCIES; RING FINGER; CONDUCTION; PREVALENCE; TESTS AB STUDY DESIGN: Descriptive. OBJECTIVES: To determine the presence of clinical and electrodiagnostic abnormalities of the median and ulnar nerves in both upper extremities of dental assistants. BACKGROUND: A high prevalence of median neuropathies at, or distal to, the wrist have been reported in dentists and dental hygienists. But there is a paucity of literature on the incidence of abnormalities of the median or ulnar nerves in dental assistants. METHODS: Thirty-five United States Army dental assistants (24 female, 11 male; age range, 18-41 years) volunteered for the study. Subjects completed a standardized history and physical examination. Nerve conduction status of the median and ulnar nerves of both upper extremities was obtained by performing motor, sensory, and F-wave (central) nerve conduction studies. RESULTS: All electrophysiological variables were normal for motor, sensory, and F-wave (central) values when compared to a chart of normal values. Based on comparison studies of median and ulnar motor latencies within the same hand, 9 subjects (26%) involving 14 hands (20%) were found to have electrodiagnostic abnormalities of the median nerve at, or distal to, the wrist. The other 26 dental assistants demonstrated normal comparison studies of the median and ulnar nerves in both upper extremities. CONCLUSIONS: In this descriptive study of 35 dental assistants, 9 subjects (26%) were found to have electrodiagnostic abnormalities of the median nerve at, or distal to, the wrist (when compared to the ulnar nerve of the same hand). Ulnar nerve electrophysiological function was within normal limits for all subjects examined. LEVEL OF EVIDENCE: Prognosis, level 4. J Orthop Sports Phys Ther 2009;39(9):693-701. doi:10.2519/jospt.2009.2995 C1 [Greathouse, David G.] Texas Phys Therapy Specialists, Clin Elect Serv, New Braunfels, TX USA. [Greathouse, David G.; Sutlive, Thomas G.; Shaffer, Scott W.; Moore, Josef H.] Baylor Univ, USA, Doctoral Program Phys Therapy, Ft Sam Houston, TX USA. RP Greathouse, DG (reprint author), 3211 Crystal Path, San Antonio, TX 78259 USA. EM greathoused1@yahoo.com FU AMEDD Center and School, Fort Sam Houston, TX FX The authors thank COL Lutka, SFC Aponte, SFC Maybeny, SSG Mason, and SSG Bradford (AMEDD Center and School, Fort Sam Houston, TX) for their support of this study and their assistance in recruiting the dental assistants that participated in the study. NR 66 TC 1 Z9 1 U1 1 U2 2 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD SEP PY 2009 VL 39 IS 9 BP 693 EP 701 DI 10.2519/jospt.2009.2995 PG 9 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 491HQ UT WOS:000269569900006 PM 19721216 ER PT J AU Hartman, KR Moncur, JT Minniti, CP Creamer, KM AF Hartman, Kip R. Moncur, Joel T. Minniti, Caterina P. Creamer, Kevin M. TI Mediastinal Kaposiform Hemangioendothelioma and Kasabach-Merritt Phenomenon in an Infant Treatment With Interferon SO JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY LA English DT Article DE Kaposiform hemangioendothelioma; Kasabach-Merritt phenomenon; interferon therapy; steroid therapy; vincristine therapy ID SPASTIC DIPLEGIA; VASCULAR TUMOR; HEMANGIOMAS; COMPLICATION; RADIOTHERAPY; VINCRISTINE; PREDNISONE AB A 2-week-old infant developed respiratory failure due to a mediastinal Kaposiform hemangioendothelioma that was complicated by thrombocytopenia and consumptive coagulopathy. Initial surgery was unsuccessful at removing the tumorous infiltration of mediastinal structures. Multiple transfusions with fresh frozen plasma, platelets.. and red blood cells were needed for the consumptive coagulopathy, and ventilatory support was required for 5 months. Therapy for the tumor included methylprednisolone, aminocaproic acid, and vincristine, but a sustained response was achieved only after the initiation of alpha interferon. The patient was monitored closely and did not develop neurologic toxicity. This case demonstrates that interferon can be used to treat infants with Kaposiform hemangioendothelioma in life-threatening situations that do not respond to other forms of treatment. C1 [Hartman, Kip R.; Moncur, Joel T.; Creamer, Kevin M.] Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. [Hartman, Kip R.; Moncur, Joel T.; Creamer, Kevin M.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Minniti, Caterina P.] NHLBI, NIH, Washington, DC USA. RP Hartman, KR (reprint author), Walter Reed Army Med Ctr, Dept Pediat, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM kip.hartman@us.army.mil NR 20 TC 8 Z9 8 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1077-4114 J9 J PEDIAT HEMATOL ONC JI J. Pediatr. Hematol. Oncol. PD SEP PY 2009 VL 31 IS 9 BP 690 EP 692 PG 3 WC Oncology; Hematology; Pediatrics SC Oncology; Hematology; Pediatrics GA 492ZK UT WOS:000269701800016 PM 19687760 ER PT J AU Toth, SI Smith, LA Ahmed, A AF Toth, Stephen I. Smith, Leonard A. Ahmed, Ashraf TI Extreme Sensitivity of Botulinum Neurotoxin Domains Towards Mild Agitation SO JOURNAL OF PHARMACEUTICAL SCIENCES LA English DT Article DE circular dichroism; solubility; proteins; protein aggregation; surfactants; thermodynamics; enzyme; botulinum neurotoxin; precipitation; inactivation ID A LIGHT-CHAIN; MECHANICAL SHAKING; THERMAL-STABILITY; AQUEOUS-SOLUTION; OXYHEMOGLOBIN-S; SEROTYPE-A; PROTEIN; AGGREGATION; DENATURATION; INHIBITORS AB Botulinum neurotoxins (BoNTs) and their fragments are targets of therapeutic developments and are increasingly used as therapeutic, prophylactic, and research reagents. However, published data on their properties vary widely. In order to gain a better understanding of these variations, we initiated a systematic investigation of the stability parameters of catalytic light chains (Lc) as well as of cell surface binding domains (Hc) of the neurotoxin. When followed by CD spectroscopy, we noticed that the recombinant light chains of serotypes A (LcA), B, D, E, and G rapidly lost their secondary structures by mild stirring. Denaturation of LcA increased with stirring speed and temperature resulting in a catalytically inactive precipitate. Reducing agents or an anaerobic environment were ineffective in the denaturation. Under identical conditions, bovine serum albumin, ovalbumin, carboxypeptidase B, and of thermolysin, a structural and functional analogue of LcA, remained unchanged. Hc domains of serotype A, 13, C, E, and F were also denatured by mild stirring. Adding the nonionic detergent Tween-20 to LcA completely prevented the denaturation. We speculate that the BoNT domains undergo surface denaturation due to rapid exposure of hydrophobic residues by mechanical agitation. This study has important implications for handling BoNT proteins used in therapeutic development. (C) 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:3302-3311, 2009 C1 [Toth, Stephen I.; Smith, Leonard A.; Ahmed, Ashraf] USA, Med Res Inst Infect Dis, Dept Mol Biol, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. RP Ahmed, A (reprint author), USA, Med Res Inst Infect Dis, Dept Mol Biol, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. EM syed.ahmed@amedd.army.mil FU JSTO-CBD [RIID 3.10011_06_RD_B] FX The research described herein was sponsored by JSTO-CBD (RIID 3.10011_06_RD_B (to SAM. We thank Dr. John Carra, Dr. Wieslaw Swietnicki, and Dr. Frank Lebeda for helpful comments and critical reading of the manuscript. NR 56 TC 11 Z9 11 U1 0 U2 1 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0022-3549 J9 J PHARM SCI-US JI J. Pharm. Sci. PD SEP PY 2009 VL 98 IS 9 BP 3302 EP 3311 DI 10.1002/jps.21676 PG 10 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology & Pharmacy SC Pharmacology & Pharmacy; Chemistry GA 491HK UT WOS:000269569200029 PM 19226630 ER PT J AU Apperson, SJ Bezmelnitsyn, AV Thiruvengadathan, R Gangopadhyay, K Gangopadhyay, S Balas, WA Anderson, PE Nicolich, SM AF Apperson, Steven J. Bezmelnitsyn, Andrey V. Thiruvengadathan, Rajagopalan Gangopadhyay, Keshab Gangopadhyay, Shubhra Balas, Wendy A. Anderson, Paul E. Nicolich, Steven M. TI Characterization of Nanothermite Material for Solid-Fuel Microthruster Applications SO JOURNAL OF PROPULSION AND POWER LA English DT Article ID PROPELLANT MICROTHRUSTER; COMPOSITES; MICROPROPULSION; PROPAGATION; NANO AB Nanothermite composites containing metallic fuel and inorganic oxidizer have unique combustion properties that make them potentially useful for microthruster applications. The thrust-generating characteristics of copper oxide/aluminum nanothermites have been investigated. The mixture was tested in various quantities (9-38 mg) by pressing the material over a range of densities. The testing was done in two different types of thrust motors: one with no nozzle and one with a convergent-divergent nozzle. As the packing density was varied, it was found that the material exhibited two distinct impulse characteristics. At low packing pressure, the combustion was in the fast regime, and the resulting thrust forces were similar to 75 N with a duration of less than 50 mu s full width at half-maximum. At high density, the combustion was relatively slow and the thrust forces were 3-5 N with a duration 1.5-3 ms. In both regimes, the specific impulse generated by the material was 20-25 s. The specific impulse and short thrust duration created by this unique nanothermite material makes it promising for micropropulsion applications, in which space is limited. C1 [Apperson, Steven J.; Bezmelnitsyn, Andrey V.; Thiruvengadathan, Rajagopalan; Gangopadhyay, Shubhra] Univ Missouri, Dept Elect & Comp Engn, Columbia, MO 65211 USA. [Gangopadhyay, Keshab] Univ Missouri, Dept Nucl Engn, Columbia, MO 65211 USA. [Balas, Wendy A.; Anderson, Paul E.; Nicolich, Steven M.] USA, Armament Res Dev & Engn Ctr, Energet & Warheads Div, Picatinny Arsenal, NJ 07896 USA. RP Apperson, SJ (reprint author), Univ Missouri, Dept Elect & Comp Engn, Room 349,Engn Bldg W, Columbia, MO 65211 USA. EM sja895@mizzou.edu; gangopadhyays@missouri.edu OI Thiruvengadathan, Rajagopalan/0000-0001-9609-3245 FU U.S. Army Armament Research Development and Engineering Center FX We gratefully acknowledge the financial support by the U.S. Army Armament Research Development and Engineering Center and the fruitful discussions with Scott Kovaleski, University of Missouri. NR 14 TC 19 Z9 20 U1 0 U2 5 PU AMER INST AERONAUTICS ASTRONAUTICS PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0748-4658 J9 J PROPUL POWER JI J. Propul. Power PD SEP-OCT PY 2009 VL 25 IS 5 BP 1086 EP 1091 DI 10.2514/1.43206 PG 6 WC Engineering, Aerospace SC Engineering GA 494UV UT WOS:000269845200011 ER PT J AU Petrov, D Shkuratov, Y Videen, G AF Petrov, Dmitry Shkuratov, Yuriy Videen, Gorden TI The Sh-matrices method applied to light scattering by small lenses SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article; Proceedings Paper CT 11th Conference on Electromagnetic and Light Scattering CY SEP 07-12, 2008 CL Univ Hertfordshire, Hatfield, ENGLAND HO Univ Hertfordshire DE T-matrix; Sh-matrix; Lens; Lens design ID PARTICLES; CAPSULE AB The introduction of the Sh-matrices in the T-matrix method allows the shape-dependent parameters to be separated from size- and refractive-index-dependent parameters. This separation also allows for the surface integrals to be solved and for analytic solutions to the light-scattering from particles of some shapes to be found. In this manuscript we derive and analyze the analytical solution for small concave lenses bounded with different spherical surfaces. Published by Elsevier Ltd. C1 [Videen, Gorden] USA, Res Lab, AMSRD ARL CI EM, Adelphi, MD 20783 USA. [Petrov, Dmitry; Shkuratov, Yuriy] Kharkov Natl Univ, Astron Inst Kharkov, UA-61022 Kharkov, Ukraine. RP Videen, G (reprint author), USA, Res Lab, AMSRD ARL CI EM, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM petrov@astron.kharkov.ua; gvideen@arl.army.mil NR 13 TC 7 Z9 7 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD SEP-NOV PY 2009 VL 110 IS 14-16 BP 1448 EP 1459 DI 10.1016/j.jqsrt.2009.01.016 PG 12 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 476TO UT WOS:000268468700020 ER PT J AU Muinonen, K Nousiainen, T Lindqvist, H Munoz, O Videen, G AF Muinonen, Karri Nousiainen, Tirno Lindqvist, Hannakaisa Munoz, Olga Videen, Gorden TI Light scattering by Gaussian particles with internal inclusions and roughened surfaces using ray optics SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article; Proceedings Paper CT 11th Conference on Electromagnetic and Light Scattering CY SEP 07-12, 2008 CL Univ Hertfordshire, Hatfield, ENGLAND HO Univ Hertfordshire DE Light scattering; Geometric optics; Diffraction; Radiative transfer; Scattering matrix; Small particles; Saharan sand ID SPHERICAL-PARTICLES; APPROXIMATION; CRYSTALS AB We study light scattering by Gaussian-random-sphere particles that are large compared to the wavelength of the incident light using ray optics that, in addition to Fresnellian reflection and refraction, accounts for diffuse scattering. We consider two types of diffusely scattering media. One type of media constitutes a uniform medium inside the particle, i.e. a diffuse internal medium. The second type of media constitutes a layer on the surface of the particle that is thin compared to the particle dimensions and acts as a diffuse external medium mimicking the particle surface roughness. We illustrate the effects of the diffuse media on the scattering characteristics for both cases and show that incorporating diffuse scatterers allows us to explain the scattering matrices measured experimentally for Saharan sand particles large compared to the wavelength. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Muinonen, Karri] Univ Helsinki, FI-00014 Helsinki, Finland. [Muinonen, Karri] Finnish Geodet Inst, FI-02431 Masala, Finland. [Nousiainen, Tirno; Lindqvist, Hannakaisa] Univ Helsinki, Dept Phys, FI-00014 Helsinki, Finland. [Munoz, Olga] CSIC, Inst Astrofis Andalucia, E-18008 Granada, Spain. [Videen, Gorden] Army Res Lab, Adelphi, MD 20783 USA. RP Muinonen, K (reprint author), Univ Helsinki, POB 14, FI-00014 Helsinki, Finland. EM Karri.Muinonen@helsinki.fi RI Nousiainen, Timo/A-7982-2008; OI Nousiainen, Timo/0000-0002-6569-9815; Munoz, Olga/0000-0002-5138-3932 NR 20 TC 25 Z9 25 U1 0 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD SEP-NOV PY 2009 VL 110 IS 14-16 BP 1628 EP 1639 DI 10.1016/j.jqsrt.2009.03.012 PG 12 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 476TO UT WOS:000268468700036 ER PT J AU Macdonald, B AF Macdonald, Brian TI Density of Complex Zeros of a System of Real Random Polynomials SO JOURNAL OF STATISTICAL PHYSICS LA English DT Article DE Random polynomials; Probability; Several complex variables; Random zeros ID EXACT STATISTICS; UNIVERSALITY; POINTS; ROOTS AB We study the density of complex zeros of a system of real random SO(m + 1) polynomials in m variables. We show that the density of complex zeros of this random polynomial system with real coefficients rapidly approaches the density of complex zeros in the complex coefficients case. We also show that the behavior the scaled density of complex zeros near R(m) of the system of real random polynomials is different in the m >= 2 case than in the m = 1 case: the density approaches infinity instead of tending linearly to zero. C1 [Macdonald, Brian] Johns Hopkins Univ, Dept Math, Baltimore, MD 21218 USA. RP Macdonald, B (reprint author), US Mil Acad, MADN MATH, 646 Swift Rd, West Point, NY 10996 USA. EM bmac@jhu.edu NR 14 TC 5 Z9 5 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-4715 J9 J STAT PHYS JI J. Stat. Phys. PD SEP PY 2009 VL 136 IS 5 BP 807 EP 833 DI 10.1007/s10955-009-9810-5 PG 27 WC Physics, Mathematical SC Physics GA 500YB UT WOS:000270341500001 ER PT J AU Brown, JW Leon, LR Le, N AF Brown, J. W. Leon, L. R. Le, N. TI Circadian Changes in Behavioral Thermoregulation and the Preferred Ambient Temperature in Two Species of Rats SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE LA English DT Meeting Abstract C1 [Brown, J. W.; Le, N.] James Madison Univ, Harrisonburg, VA 22807 USA. [Leon, L. R.] USA, Res Inst Envrn Med, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1559-6109 J9 J AM ASSOC LAB ANIM JI J. Amer. Assoc. Lab. Anim. Sci. PD SEP PY 2009 VL 48 IS 5 BP 595 EP 595 PG 1 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 502SI UT WOS:000270480000220 ER PT J AU Pflipsen, MC Oh, RC Saguil, A Seehusen, DA Topolski, R AF Pflipsen, Matthew C. Oh, Robert C. Saguil, Aaron Seehusen, Dean A. Topolski, Richard TI The Prevalence of Vitamin B(12) Deficiency in Patients with Type 2 Diabetes: A Cross-Sectional Study SO JOURNAL OF THE AMERICAN BOARD OF FAMILY MEDICINE LA English DT Article ID TOTAL HOMOCYSTEINE CONCENTRATIONS; SERUM METHYLMALONIC ACID; COBALAMIN DEFICIENCY; FOLATE-DEFICIENCY; METFORMIN; DIAGNOSIS; SUPPLEMENTATION; POPULATION; NEUROPATHY; MELLITUS AB Purpose: The purpose of this study is to define the prevalence of vitamin B(12) deficiency in a type 2 diabetic population within a primary care practice. Metformin use and advanced age are associated with vitamin B(12) deficiency and often present in type 2 diabetic patients, yet the prevalence of vitamin B(12) deficiency in the diabetic population is unknown. Methods: We conducted a cross-sectional study of 203 outpatient type 2 diabetic patients at a large military primary care clinic. Patients completed a survey and had B(12) levels measured. Patients with borderline B(12) levels also had methylmalonic acid and homocysteine levels drawn. Serum B(12) levels < 100 pg/mL or serum B(12) levels of 100 to 350 pg/mL with elevation of serum methylmalonic acid > 243 nmol/L or homocysteine > 11.9 nmol/L defined B(12) deficiency. Descriptive statistics described frequency and means. chi(2) and student's t tests were used to analyze associations between categorical and continuous variables, respectively. Multivariate logistical regression identified covariates independently associated with B(12) deficiency. Results: Twenty-two percent (n = 44) of diabetic patients had metabolically confirmed B(12) deficiency. Patients on metformin had lower serum B(12) levels (425.99 pg/mL vs 527.49 pg/mL; P = .012) and were at increased risk for B(12) deficiency (P = .04), as defined by a serum B(12) level < 350 pg/mL. Prevalence of B(12) deficiency was significantly lower for patients using a multivitamin (odds ratio, 0.31; 95% CI, 0.15-0.63). Conclusions: Our results found a 22% prevalence of metabolically confirmed B(12) deficiency in the primary care type 2 diabetic population. Although further research needs to be performed to determine the clinical implications of our findings, B(12) deficiency should be considered in type 2 diabetic patients, especially those taking metformin. Furthermore, a daily multivitamin may protect against B(12) deficiency. (J Am Board Fam Med 2009; 22: 528-534.) C1 [Pflipsen, Matthew C.] Raymond W Bliss Army Hlth Ctr, Dept Primary Care, Ft Huachuca, AZ 85613 USA. [Oh, Robert C.] Tripler Army Med Ctr, Dept Family Med, Honolulu, HI 96859 USA. [Saguil, Aaron; Seehusen, Dean A.] Eisenhower Army Med Ctr, Dept Family & Community Med, Ft Gordon, GA USA. [Topolski, Richard] Augusta State Univ, Dept Psychol, Augusta, GA USA. RP Pflipsen, MC (reprint author), Raymond W Bliss Army Hlth Ctr, Dept Primary Care, 2240 E Winrow Ave, Ft Huachuca, AZ 85613 USA. EM matthew.pflipsen@us.army.mil FU The Madigan Army Medical Center Clinical Investigation FX Funding: The Madigan Army Medical Center Clinical Investigation committee provided the funding to complete this study. NR 31 TC 39 Z9 43 U1 1 U2 7 PU AMER BOARD FAMILY MEDICINE PI LEXINGTON PA 2228 YOUNG DR, LEXINGTON, KY 40505 USA SN 1557-2625 J9 J AM BOARD FAM MED JI J. Am. Board Fam. Med. PD SEP-OCT PY 2009 VL 22 IS 5 BP 528 EP 534 DI 10.3122/jabfm.2009.05.090044 PG 7 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 491NU UT WOS:000269586600011 PM 19734399 ER PT J AU Mace, JE White, CE Simmons, JW Borgman, MA Perkins, JG Schreiber, MA Spinella, PC Wade, CE Blackbourne, LH AF Mace, James E. White, Christopher E. Simmons, John W. Borgman, Matthew A. Perkins, Jeremy G. Schreiber, Martin A. Spinella, Phillip C. Wade, Charles E. Blackbourne, Lorne H. TI High plasma to RBC ratio improves survival based on mechanism of combat injury in massively transfused patients SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Meeting Abstract CT 95th Annual Clinical Congress of the American-College-of-Surgeons/64th Annual Sessions of the Owen H Wangensteen Forum on Fundamental Surgical Problems CY OCT 11-15, 2009 CL Chicago, IL SP Amer Coll Surg C1 [Mace, James E.; White, Christopher E.; Simmons, John W.; Borgman, Matthew A.; Perkins, Jeremy G.; Schreiber, Martin A.; Spinella, Phillip C.; Wade, Charles E.; Blackbourne, Lorne H.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RI Borgman, Matthew/L-9477-2015 OI Borgman, Matthew/0000-0002-2008-7380 NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD SEP PY 2009 VL 209 IS 3 SU S BP S47 EP S47 PG 1 WC Surgery SC Surgery GA 493RJ UT WOS:000269755300096 ER PT J AU Rice, RD Tsai, JW Pham, T Ayubi, FS Franco, NA White, PW Armstrong, PJ AF Rice, Robert D. Tsai, John W. Pham, Thach Ayubi, Farhan S. Franco, Nelson A. White, Paul W. Armstrong, Peter J. TI Evaluation of porcine dermal collagen (Permacol) and porcine small-intestinal submucosa (Surgisis) as a vascular conduit for interposition in a rabbit model (Oryctolagus cuniculus) SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Meeting Abstract CT 95th Annual Clinical Congress of the American-College-of-Surgeons/64th Annual Sessions of the Owen H Wangensteen Forum on Fundamental Surgical Problems CY OCT 11-15, 2009 CL Chicago, IL SP Amer Coll Surg C1 [Rice, Robert D.; Tsai, John W.; Pham, Thach; Ayubi, Farhan S.; Franco, Nelson A.; White, Paul W.; Armstrong, Peter J.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD SEP PY 2009 VL 209 IS 3 SU S BP S140 EP S140 PG 1 WC Surgery SC Surgery GA 493RJ UT WOS:000269755300318 ER PT J AU Kheirabadi, BS Scherer, MR Estep, JS Dubick, MA Holcomb, JB AF Kheirabadi, Bijan S. Scherer, Michael R. Estep, J. Scot Dubick, Michael A. Holcomb, John B. TI Determination of Efficacy of New Hemostatic Dressings in a Model of Extremity Arterial Hemorrhage in Swine SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 22nd Annual Meeting of the Eastern-Association-for-the-Surgery-of-Trauma CY JAN 13-17, 2009 CL Lake Buena Vista, FL SP Eastern Assoc Surg Trauma DE Combat gauze; TraumaStat; Celox D; HemCon; Hemorrhage control; Side effect; Swine ID HIGHLY POROUS SILICA; GAUZE SPONGES; HEMCON; EPIDEMIOLOGY; SUPERIOR; INJURY; DEATH AB Background: The HemCon (HC) bandage and QuickClot have been used over the past 6 years for treating external compressible hemorrhage In combat casualties. Previously, we tested three new hemostatic agents in granular/powder forms that were superior to these products. In this study, four new dressings (preselected) that are more suitable for battlefield application were evaluated. The efficacy and acute safety of the dressings were tested in our standard arterial hemorrhage model. Methods: Anesthetized pigs (n = 38, 37 kg) were instrumented, and arterial blood was collected for hematological and coagulation assays. After splenectomy, the right femoral artery was isolated, injured (6 mm arteriotomy), and unrestricted bleeding allowed for 45 seconds. A hemostatic dressing (HC RTS [n = 6], Celox-D [CXb, n = 6], TraumaStat [TS, n = 10], Combat Gauze [CG, n = 10], or placebo gauze [PG, n = 6]) was then applied over the wound randomly and compressed for 2 minutes. Fluid resuscitation was administered and titrated to maintain a mean arterial pressure of 65 mm Hg. Animals were observed for 180 minutes or until death. Computed tomography angiography was performed on survivors and tissues were collected for histology. Results: No differences were found in baseline blood measures, pretreatment blood loss or fluid infusion among groups. HCs and CXb testing discontinued after six unsuccessful tests, and the data were excluded. Stable hemostasis was achieved in two PG, two TS, and eight CG pigs in remaining groups resulting in stabilized mean arterial pressure and significantly different survival rates (20-80%, p = 0.03). CG secured hemostasis for 134.6 minutes +/- 22.2 minutes, which was significantly longer than TS (35.7 +/- 22.0 minutes, p < 0.05) but not different from PG (57.9 +/- 36.2 minutes). The average survival time of CG-treated animals (167.3 +/- 5.9 minutes) was also significantly longer (p < 0.05) than that of TS- (90.0 +/- 15.3 minutes) or PG-treated (121 +/- 19.3 minutes) pigs. Posttreatment blood loss was less in CG (37.4 +/- 17.3 mL/kg) than that of the two other groups (TS = 79.8 +/- 13.8 mL/kg and PG = 75.5 +/- 23.8 mL/kg), but this difference was not significant. No significant rise in wound temperature (>1 degrees C) was recorded after treatment with dressings and computed tomography images showed no flow through the vessels. Histologic observations showed mild to moderate changes in treated vessels with no difference between CG and PG. In vitro analysis of blood treated with CG or PG (lesser extent) showed increased clotting rate and clot strength. TS treatment had no effect on blood clotting activity. Conclusion: CG was the most effective dressing tested in this arterial hemorrhage model. The hemostatic property of CG is attributed to its raw material (nonwoven Rayon and polyester blend), kaolin coating, and the large surface area (3 inch X 4 yd) of this absorbent sponge. CG is now recommended as the first line of treatment for life-threatening hemorrhage on the battlefield, replacing HC. C1 [Kheirabadi, Bijan S.; Scherer, Michael R.; Estep, J. Scot; Dubick, Michael A.; Holcomb, John B.] USA, Inst Surg Res, Damage Control Resuscitat Div, Ft Sam Houston, TX 78234 USA. RP Kheirabadi, BS (reprint author), 3400 Rawley E,Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM bijan.kheirabadi@us.army.mil NR 17 TC 76 Z9 77 U1 2 U2 20 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD SEP PY 2009 VL 67 IS 3 BP 450 EP 460 DI 10.1097/TA.0b013e3181ac0c99 PG 11 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 493IL UT WOS:000269729900006 PM 19741385 ER PT J AU Cho, RI Bakken, HE Reynolds, ME Schlifka, BA Powers, DB AF Cho, Raymond I. Bakken, Hans E. Reynolds, Mark E. Schlifka, Brett A. Powers, David B. TI Concomitant Cranial and Ocular Combat Injuries During Operation Iraqi Freedom SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Combat; Cranial trauma; Ocular trauma; Operation Iraqi Freedom ID ENDURING FREEDOM; NECK INJURIES; MAJOR TRAUMA; WAR INJURIES; HEAD AB Background: Concomitant cranial and ocular injuries were frequently seen in combat casualties during Operation Iraqi Freedom. The incidence of these injuries is reported along with an interventional case series. Methods: A retrospective review was conducted of all surgical patients treated by U.S. Army neurosurgeons and ophthalmologists in Iraq from December 2005 to April 2006. Results: Out of 104 patients with cranial trauma and 158 patients with ocular trauma, 34 had both cranial and ocular injuries (132.7 and 21.5% of patients with cranial and ocular injuries, respectively). Neurosurgical procedures included exploratory craniotomy, decompressive craniectomy, and frontal sinus surgery. Ophthalmologic surgical procedures included globe exploration, open globe repair, primary enucleation, orbital fracture repair, lateral canthotomy and cantholysis, and repair of lid and periocular lacerations. Patients with cranial trauma had a higher incidence of orbital fracture, orbital compartment syndrome, and multiple ocular injuries compared with patients without cranial trauma (odds ratio 6.4, 3.9, and 3.3, respectively). Conclusion: A strong association exists between cranial and ocular trauma in combat casualties treated during Operation Iraqi Freedom. Combat health support personnel should maintain a high level of suspicion for one of these injuries when the other is present. Co-locating neurosurgeons and ophthalmologists in support of combat operations facilitates the optimal treatment of patients with these combined injuries. C1 [Cho, Raymond I.] Brooke Army Med Ctr, Opthamol Serv, Ft Sam Houston, TX 78234 USA. [Bakken, Hans E.] Madigan Army Med Ctr, Neurosurg Serv, Ft Lewis, WA USA. [Reynolds, Mark E.] Walter Reed Army Med Ctr, Dept Prevent Med, Washington, DC 20307 USA. Geisinger Wyoming Valley Med Ctr, Dept Neurosurg, Wilkes Barre, PA USA. [Powers, David B.] Univ Maryland, R Adams Cowley Shock Trauma Ctr, Baltimore, MD 21201 USA. RP Cho, RI (reprint author), Brooke Army Med Ctr, Opthamol Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM raymond.cho@army.mil NR 21 TC 7 Z9 7 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD SEP PY 2009 VL 67 IS 3 BP 516 EP 519 DI 10.1097/TA.0b013e3181a5f08d PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 493IL UT WOS:000269729900015 PM 19741393 ER PT J AU Lim, W Douglas, EA Lee, J Jang, J Craciun, V Norton, DP Pearton, SJ Ren, F Son, SY Yuh, JH Shen, H Chang, W AF Lim, Wantae Douglas, E. A. Lee, Jaewon Jang, Junghun Craciun, V. Norton, D. P. Pearton, S. J. Ren, F. Son, S. Y. Yuh, J. H. Shen, H. Chang, W. TI Transparent dual-gate InGaZnO thin film transistors: OR gate operation SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article ID AMORPHOUS OXIDE SEMICONDUCTORS; ROOM-TEMPERATURE; PERFORMANCE; TFTS AB Transparent dual-gate (DG) InGaZnO4 thin film transistors for OR logic operation were fabricated on a glass substrate. A 100-nm-thick SiO2 layer used as both top and bottom gate dielectrics was deposited by plasma enhance chemical vapor deposition at 200 degrees C. Compared to bottom gate, top gate thin film transistors (TFTs) exhibited better device performance with higher saturation mobility, drain current on-to-off ratio, lower threshold voltage, and subthreshold gate-voltage swing. This improved performance was mainly attributed to low process-induced damage or low parasitic capacitance between gate and source/drain and low parasitic resistance between channel and source/drain in top-contact TFT configuration (coplanar type). DG-mode TFTs showed saturation mobility of similar to 16.9 cm(2) V-1 s(-1), drain current on-to-off ratio of similar to 1 X 10(6), subthreshold gate-voltage swing of similar to 0.33 V decade(-1), and threshold voltage of similar to 1.25 V. The results demonstrate that DG InGaZnO4 TFTs are effective in improving the device performance because the channel layer is modulated independently by a top or, bottom gate signal and are well suited for OR gate operation. (C) 2009 American Vacuum Society. [DOI:10.1116/1.3196787] C1 [Lim, Wantae; Douglas, E. A.; Lee, Jaewon; Jang, Junghun; Craciun, V.; Norton, D. P.; Pearton, S. J.] Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. [Ren, F.] Univ Florida, Dept Chem Engn, Gainesville, FL 32611 USA. [Son, S. Y.; Yuh, J. H.] Appl Mat Inc, Santa Clara, CA 95054 USA. [Shen, H.; Chang, W.] Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. RP Lim, W (reprint author), Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. EM spear@mse.ufl.edu RI Craciun, Valentin/C-4789-2011; Douglas, Erica/J-3732-2014 OI Douglas, Erica/0000-0003-1873-0223 FU (U.S.) Army Research Office [DAAD19-01-1-0603]; Army Research Laboratory; NSF [DMR 0700416] FX The work at UF was supported by the (U.S.) Army Research Office under Grant No. DAAD19-01-1-0603 (monitored by Dr. M. Gerhold) and the Army Research Laboratory and NSF (Grant No. DMR 0700416, Dr. L. Hess). The authors thank UFNF staff for their help in the performance of this work. NR 22 TC 12 Z9 13 U1 1 U2 11 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD SEP PY 2009 VL 27 IS 5 BP 2128 EP 2131 DI 10.1116/1.3196787 PG 4 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA 502HH UT WOS:000270447400013 ER PT J AU Lantz, KR Pate, R Stiff-Roberts, AD Duffell, AG Smith, ER Everitt, HO AF Lantz, K. R. Pate, R. Stiff-Roberts, A. D. Duffell, A. G. Smith, E. R. Everitt, H. O. TI Comparison of conjugated polymer deposition techniques by photoluminescence spectroscopy SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article ID LIGHT-EMITTING-DIODES; PULSED-LASER EVAPORATION; ORGANIC THIN-FILMS; MEH-PPV FILMS; DEVICE PERFORMANCE; MORPHOLOGY AB The effects of various deposition techniques on the photoluminescence spectra of the conjugated polymer poly[2-methoxy-5-(2'-ethylhexyloxy)-1,4-(1-cyanovinylene) phenylene] (MEH-CN-PPV) are investigated. Photoluminescence spectroscopy provides insight to the internal morphology of organic thin films through the identification of interchain or intrachain recombination peaks. Thin films were deposited on glass substrates by drop casting, spin casting, and resonant-infrared matrix-assisted pulsed laser evaporation (RIR-MAPLE) and were compared to the photoluminescence of the polymer in solution. The photoluminescence measurements reported in this article demonstrate that samples deposited by evaporative RIR-MAPLE have an internal morphology similar to that of MEH-CN-PPV in solution, leading to an enhancement of intrachain transitions in the conjugated polymer. (C) 2009 American Vacuum Society. [DOI: 10.1116/1.3222855] C1 [Lantz, K. R.; Pate, R.; Stiff-Roberts, A. D.] Duke Univ, Dept Elect & Comp Engn, Durham, NC 27708 USA. [Duffell, A. G.; Everitt, H. O.] US Army Aviat & Missile Res, Ctr Dev & Engn, Redstone Arsenal, AL USA. [Smith, E. R.] Digital Fus, Huntsville, AL 35805 USA. [Everitt, H. O.] Duke Univ, Dept Phys, Durham, NC 27708 USA. RP Lantz, KR (reprint author), Duke Univ, Dept Elect & Comp Engn, Durham, NC 27708 USA. EM adrienne.stiffroberts@duke.edu RI Everitt, Henry/L-7118-2013 OI Everitt, Henry/0000-0002-8141-3768 FU National Science Foundation [0547273] FX This work was supported in part by the Army competitive in-house innovative laboratory research program and by the National Science Foundation under Grant No. 0547273. NR 22 TC 8 Z9 8 U1 0 U2 8 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD SEP PY 2009 VL 27 IS 5 BP 2227 EP 2231 DI 10.1116/1.3222855 PG 5 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA 502HH UT WOS:000270447400030 ER PT J AU Gifford, SM Aidinian, G Clouse, WD Fox, CJ Porras, CA Jones, WT Zarzabal, LA Michalek, JE Propper, BW Burkhardt, GE Rasmussen, TE AF Gifford, Shaun M. Aidinian, Gilbert Clouse, W. Darrin Fox, Charles J. Porras, Chantel A. Jones, W. Tracey Zarzabal, Lee Ann Michalek, Joel E. Propper, Brandon W. Burkhardt, Gabriel E. Rasmussen, Todd E. TI Effect of temporary shunting on extremity vascular injury: An outcome analysis from the Global War on Terror vascular injury initiative SO JOURNAL OF VASCULAR SURGERY LA English DT Article; Proceedings Paper CT 33rd Annual Meeting of the Southern-Association-for-Vascular-Surgery CY JAN 14-17, 2009 CL Tucson, AZ SP SE Assoc Vasc Surg ID INTRALUMINAL ARTERIAL SHUNTS; OPERATION-IRAQI-FREEDOM; VENOUS INJURIES; SYSTEMIC ANTICOAGULATION; PROLONGED USE; MANAGEMENT; TRAUMA; REPAIR; EXPERIENCE; REGISTRY AB Objective: Extremity vascular injury during the current war has been defined by anecdotal description and case series. These reports focused on estimation of short-term limb viability and technical description of commonly used adjuncts. Temporary vascular shunting (TVS) has been advocated in current care structures, yet mostly due to war environments, broader statistical scrutiny is lacking. This study's purpose is to provide perspective on TVS's impact on limb salvage, and estimate longer-term freedom from amputation. Methods: Data from the joint Theater Trauma Registry (JTTR), Balad Vascular Registry (BVR), Walter Reed Vascular Registry (WRVR), electronic medical records, and patient interviews were collected on American Troops sustaining extremity vascular injury front June 2003 through December 2007. Those in whom arterial TVS utilization was identified comprise the TVS group. These were compared with controls with similar injury date and anatomic location managed without TVS. Descriptive statistics were employed establishing overall univariate predictors of amputation and comparison between groups. Proportional-hazards modeling, with propensity score adjustment for systemic injury severity and Level 2 care, characterized risk factors of limb loss and effect of TVS. Freedom from amputation was estimated using Kaplan Meier log-rank methods. Results. Cases and controls consisted of 64 and 61 extremity arterial injuries, respectively. Mean follow-up was 22 months (range: 1-54 months). The TVS group was more severely injured (mean injury severity score [ISS]: 18 [SD = 10] TVS vs. 15 [SD = 10] control, P = .05) and more likely to receive Level 2 care (TVS: 26%; control: 10%, P = .02). Overall, a total of 26 amputations occurred (21%). Penetrating blasts, compared with gunshot wounds, were associated with amputation (30% vs. 6%, P = .002). After propensity score adjustment, use of TVS suggested a reduced risk of amputation (relative risk [RR] = 0.47; 95% confidence interval [CI] [0.18-1.19]; P =. 11). Venous repair was associated with limb salvage (RR = 0.2; 95% CI [0.04-0.99], P = .05). Associated fracture (RR = 5.0; 95% CI [1.45-17.28], P = .01), and elevated mangled extremity severity score (MESS) ([MESS 5-7] RR = 3.5, 95% CI [0.97-12.36], P = .06; [MESS 8-12] RR = 16.4; 95% CI (3.79-70.79), P < .001) predicted amputation. Amputation-free survival was 78% in the TVS group and 77% in the control group at three years (P = .5). Conclusion: Temporary vascular shunting used as a damage control adjunct in management of wartime extremity vascular injury does not lead to worse outcomes. Benefit from TVS is suggested, but not statistically significant. Injury specific variables of venous ligation, associated fracture, and penetrating blast mechanism are associated with amputation. Amputation-free survival after vascular injury in Operation Iraqi Freedom is 79% at three years. Further studies to statistically define any possible benefits of TVS are needed. (J Vasc Surg 2009;50:549-56.) C1 [Gifford, Shaun M.; Clouse, W. Darrin; Porras, Chantel A.; Jones, W. Tracey; Propper, Brandon W.; Burkhardt, Gabriel E.; Rasmussen, Todd E.] San Antonio Mil Med Ctr, San Antonio, TX USA. [Aidinian, Gilbert; Fox, Charles J.] Walter Reed Army Med Ctr, Washington, DC USA. [Clouse, W. Darrin; Fox, Charles J.; Propper, Brandon W.; Burkhardt, Gabriel E.; Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Sch Med, Bethesda, MD 20814 USA. [Gifford, Shaun M.; Zarzabal, Lee Ann; Michalek, Joel E.; Propper, Brandon W.; Burkhardt, Gabriel E.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Clouse, WD (reprint author), USAF MC, Chief San Antonio Mil Vasc Surg Serv, 2200 Bergquist Dr,Ste 1, Lackland AFB, TX 78236 USA. EM william.clouse@us.af.mil NR 37 TC 52 Z9 52 U1 0 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD SEP PY 2009 VL 50 IS 3 BP 549 EP 556 DI 10.1016/j.jvs.2009.03.051 PG 8 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 488KG UT WOS:000269347900011 PM 19595542 ER PT J AU Nedellec, R Coetzer, M Shimizu, N Hoshino, H Polonis, VR Morris, L Martensson, UEA Binley, J Overbaugh, J Mosier, DE AF Nedellec, R. Coetzer, M. Shimizu, N. Hoshino, H. Polonis, V. R. Morris, L. Martensson, U. E. A. Binley, J. Overbaugh, J. Mosier, D. E. TI Virus Entry via the Alternative Coreceptors CCR3 and FPRL1 Differs by Human Immunodeficiency Virus Type 1 Subtype SO JOURNAL OF VIROLOGY LA English DT Article ID PROTEIN-COUPLED RECEPTOR; BRAIN-DERIVED CELLS; CHEMOKINE RECEPTORS; DISEASE PROGRESSION; HIV-1 INFECTION; ENVELOPE DETERMINANTS; V3 LOOP; FUSION COFACTORS; DIVERSE HUMAN; CO-RECEPTORS AB Human immunodeficiency virus type 1 (HIV-1) infects target cells by binding to CD4 and a chemokine receptor, most commonly CCR5. CXCR4 is a frequent alternative coreceptor (CoR) in subtype B and D HIV-1 infection, but the importance of many other alternative CoRs remains elusive. We have analyzed HIV-1 envelope (Env) proteins from 66 individuals infected with the major subtypes of HIV-1 to determine if virus entry into highly permissive NP-2 cell lines expressing most known alternative CoRs differed by HIV-1 subtype. We also performed linear regression analysis to determine if virus entry via the major CoR CCR5 correlated with use of any alternative CoR and if this correlation differed by subtype. Virus pseudotyped with subtype B Env showed robust entry via CCR3 that was highly correlated with CCR5 entry efficiency. By contrast, viruses pseudotyped with subtype A and C Env proteins were able to use the recently described alternative CoR FPRL1 more efficiently than CCR3, and use of FPRL1 was correlated with CCR5 entry. Subtype D Env was unable to use either CCR3 or FPRL1 efficiently, a unique pattern of alternative CoR use. These results suggest that each subtype of circulating HIV-1 may be subject to somewhat different selective pressures for Env-mediated entry into target cells and suggest that CCR3 may be used as a surrogate CoR by subtype B while FPRL1 may be used as a surrogate CoR by subtypes A and C. These data may provide insight into development of resistance to CCR5-targeted entry inhibitors and alternative entry pathways for each HIV-1 subtype. C1 [Nedellec, R.; Coetzer, M.; Mosier, D. E.] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA. [Shimizu, N.; Hoshino, H.] Gunma Univ, Grad Sch Med, Dept Virol & Prevent Med, Gunma 3718511, Japan. [Polonis, V. R.] Walter Reed Army Inst Res, Div Retrovirol, Washington, DC 20307 USA. [Morris, L.] Natl Inst Communicable Dis, ZA-2131 Johannesburg, South Africa. [Martensson, U. E. A.] Lund Univ, Wallenburg Neurosci Ctr, Div Mol Neurobiol, SE-22362 Lund, Sweden. [Binley, J.] Torrey Pines Inst Mol Studies, San Diego, CA 92121 USA. [Overbaugh, J.] Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA. RP Mosier, DE (reprint author), Scripps Res Inst, Dept Immunol, IMM 7,10550 N Torrey Pines Rd, La Jolla, CA 92037 USA. EM dmosier@scripps.edu OI , Lynn/0000-0003-3961-7828 FU NIH [AI052778, AI071935, AI058763]; James B. Pendleton Charitable Trust FX This research was supported by NIH grants AI052778, AI071935 (D. E. M.), and AI058763 (J. B.) and by the James B. Pendleton Charitable Trust. NR 81 TC 26 Z9 27 U1 1 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD SEP PY 2009 VL 83 IS 17 BP 8353 EP 8363 DI 10.1128/JVI.00780-09 PG 11 WC Virology SC Virology GA 485LF UT WOS:000269122300005 PM 19553323 ER PT J AU Langsdale, SM Beall, A Carmichael, J Cohen, SJ Forster, CB Neale, T AF Langsdale, Stacy M. Beall, Allyson Carmichael, Jeff Cohen, Stewart J. Forster, Craig B. Neale, Tina TI Exploring the Implications of Climate Change on Water Resources through Participatory Modeling: Case Study of the Okanagan Basin, British Columbia SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT-ASCE LA English DT Article ID SYSTEM DYNAMICS; MANAGEMENT; CHALLENGE; SCALE AB Few regions in North America have directly incorporated the implications of climate change in water resources planning initiatives because the relevant information is not readily accessible, and methods for adjusting policy and operations are not obvious. To help one community and to provide an example for managers of other watersheds, we engaged stakeholders in a group model building process to explore plausible water resources futures for the Okanagan Basin, British Columbia, Canada. The process was conducted by a team of academic and federal government researchers and comprised of a sequence of five one-day participatory workshops held within the basin over a 12-month period. Primary workshop objectives included: creating a shared learning experience, developing a customized exploration tool, and fostering trust in the model among the participants. Survey results indicate that the exercise helped participants to expand their thinking to the basin scale and to appreciate the complexity of water management. Participants found the resulting model to be suitable for futures exploration and outreach; however, the high turnover rate in participation limited the sense of ownership in the model by the completion of the final session. C1 [Langsdale, Stacy M.] USA, Corps Engineers, Inst Water Resources, Alexandria, VA 22315 USA. [Beall, Allyson] Univ Idaho, Moscow, ID 83844 USA. [Beall, Allyson] Washington State Univ, Sch Earth & Environm Sci, Pullman, WA 99164 USA. [Carmichael, Jeff] Metro Vancouver, Policy & Planning, Burnaby, BC V5H 4G8, Canada. [Carmichael, Jeff] Univ British Columbia, Inst Resources Environm & Sustainabil, Vancouver, BC V6T 1Z4, Canada. [Cohen, Stewart J.] Environm Canada, AIRD, Vancouver, BC V6T 1Z4, Canada. [Cohen, Stewart J.] Univ British Columbia, Dept Forest Resources Management, Vancouver, BC V6T 1Z4, Canada. [Forster, Craig B.] Univ Utah, Off Sustainabil, Salt Lake City, UT 84112 USA. [Forster, Craig B.] Univ Utah, Coll Architecture Planning, Salt Lake City, UT 84112 USA. [Neale, Tina] British Columbia Minist Environm, Victoria, BC V8T 5J9, Canada. RP Langsdale, SM (reprint author), USA, Corps Engineers, Inst Water Resources, 7701 Telegraph Rd,Casey Bldg, Alexandria, VA 22315 USA. EM slangsdale@gmail.com FU Government of Canada's Climate Change Impacts and Adaptation Program [A846] FX This project was made possible with financial support from the Government of Canada's Climate Change Impacts and Adaptation Program (Project No. A846). The writers sincerely appreciate the contributions of all the Okanagan Basin participants who made this work possible. NR 41 TC 24 Z9 24 U1 0 U2 15 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9496 J9 J WATER RES PL-ASCE JI J. Water Resour. Plan. Manage.-ASCE PD SEP-OCT PY 2009 VL 135 IS 5 BP 373 EP 381 DI 10.1061/(ASCE)0733-9496(2009)135:5(373) PG 9 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA 484QM UT WOS:000269061900008 ER PT J AU Stojadinovic, A Peoples, GE Jurgens, JS Howard, RS Schuyler, B Kwon, KH Henry, LR Shriver, CD Buckenmaier, CC AF Stojadinovic, Alexander Peoples, George E. Jurgens, Jennifer S. Howard, Robin S. Schuyler, Brandi Kwon, Kyung H. Henry, Leonard R. Shriver, Craig D. Buckenmaier, Chester C. TI Standard versus pH-adjusted and lidocaine supplemented radiocolloid for patients undergoing sentinel-lymph-node mapping and biopsy for early breast cancer (PASSION-P trial): a double-blind, randomised controlled trial SO LANCET ONCOLOGY LA English DT Article ID AXILLARY DISSECTION; LYMPHOSCINTIGRAPHY; LYMPHADENECTOMY; VALIDATION; IMAGES AB Background Sentinel-lymph-node (SLN) mapping and biopsy maintains staging accuracy in early breast cancer and identifies patients for selective lymphadenectomy. SLN mapping requires injection of technetium-99m-sulfur colloid-an effective but sometimes painful method, for which better pain-management strategies are needed. In this randomised, double-blind trial, we compared degree of pain between standard radiocolloid injection and pH-adjusted and lidocaine-supplemented formulations for patients undergoing SLN mapping for breast cancer. Methods Between Jan 13, 2006, and April 30, 2009, 140 patients with early breast cancer were randomly assigned in a 1:1:1:1 fashion to receive the standard topical 4% lidocaine cream and injection of [(99m)Tc]Tc-sulfur colloid (n=35), or to one of three other study groups: topical placebo cream and injection of Tc-sulfur colloid containing either sodium bicarbonate (n=35), 1% lidocaine (n=35), or sodium bicarbonate and 1% lidocaine (n=35). The randomisation sequence was computer generated, and all patients and investigators were masked to treatment allocation. The primary endpoint was patient-reported breast pain immediately after radioisotope injection, using the Wong-Baker FACES pain rating scale and McGill pain questionnaire, analysed in the per-protocol population. This study is registered with ClinicalTrials.gov, number NCT00940199. Findings 19 of the 140 patients enrolled were excluded from analysis: nine declined study participation or sought care elsewhere, nine did not undergo SLN mapping because of disease extent or a technical problem, and one had unreliable data. There were no adverse events. Mean pain scores on the Wong-Baker scale (0-10) were: 6.0 (SD 2.6) for those who received standard of practice, 4.7 (3.0) for those who received radiocolloid plus bicarbonate, 1.6 (1.4) for those who received radiocolloid plus 1% lidocaine, and 1.6 (1.3) for those who received radiocolloid Plus bicarbonate and 1% lidocaine (p<0.0001). Mean pain rating, according to the McGill questionnaire (0-78), was 17.5 (SD 11.8) for the standard-of-care group, 15.4 (14-4) for the sodium bicarbonate group, 4.6 (4.5) for the 1% lidocaine group, and 3.4 (5.1) for the sodium bicarbonate plus 1% lidocaine group (p<0.0001). SLN identification rates for each group were: 96% for the standard of care, 97% for sodium bicarbonate, 90% for 1% lidocaine, and 90% for sodium bicarbonate plus 1% lidocaine group (p=0.56). Interpretation For centres that use radiocolloid injections for SLN mapping in patients with early breast cancer, the addition of 1% lidocaine to the radioisotope solution can improve patient comfort, without compromising SLN identification. C1 [Stojadinovic, Alexander] Walter Reed Army Med Ctr, US Mil Canc Inst, Dept Surg, Div Surg Oncol, Washington, DC 20307 USA. [Jurgens, Jennifer S.; Schuyler, Brandi] Walter Reed Army Med Ctr, Dept Radiol, Nucl Med Serv, Washington, DC 20307 USA. [Howard, Robin S.] Walter Reed Army Med Ctr, Biometr Sect, Dept Clin Invest, Washington, DC 20307 USA. [Kwon, Kyung H.; Buckenmaier, Chester C.] Walter Reed Army Med Ctr, Dept Surg Anesthesia & Operat Serv, Washington, DC 20307 USA. [Shriver, Craig D.] Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC 20307 USA. [Kwon, Kyung H.; Buckenmaier, Chester C.] Walter Reed Army Med Ctr, Army Reg Pain Management Initiat, Washington, DC 20307 USA. [Stojadinovic, Alexander; Peoples, George E.; Henry, Leonard R.; Shriver, Craig D.] US Mil Canc Inst, Clin Trials Grp, Washington, DC USA. [Peoples, George E.] Brooke Army Med Ctr, Div Surg Oncol, Dept Surg, Houston, TX USA. [Henry, Leonard R.] Natl Naval Med Ctr, Dept Surg, Bethesda, MD USA. RP Stojadinovic, A (reprint author), Walter Reed Army Med Ctr, US Mil Canc Inst, Dept Surg, Div Surg Oncol, 6900 Georgia Ave, Washington, DC 20307 USA. EM alexander.stojadinovic@amedd.army.mil FU US Military Cancer Institute; Clinical Breast Care Project; Army Regional Anesthesia and Pain Management Initiative; Henry M Jackson Foundation for the Advancement of Military Medicine; Army Medical Center; National Naval Medical Center FX We thank Tiffany Felix for her invaluable assistance supported, in part, by the Henry M Jackson Foundation for the Advancement of Military Medicine, and Robert Massey for the preparation and quality control of the radioisotope used in this study. We thank the staff at Walter Reed Army Medical Center and National Naval Medical Center for their skilled and compassionate care for our patients. We are also grateful to the members and staff of the Army Regional Anesthesia and Pain Management Initiative, Clinical Breast Care Project, and US Military Cancer Institute for their support. There was no extramural support for this trial. All funding was obtained from intramural programmes at Walter Reed Army Medical Center (AS, JSJ, RSH, BS, KHK, CDs, CCB) including, the United States Military Cancer Institute (GEP, AS), the Clinical Breast Care Project (CDS, AS) and the Army Regional Anesthesia and Pain Management Initiative (KHK, CCIL AS). The views expressed here are those of the authors and do not reflect the official policy of the US Department of the Army, the US Department of the Navy, the US Department of Defense, or the US Government. NR 13 TC 12 Z9 12 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1470-2045 J9 LANCET ONCOL JI Lancet Oncol. PD SEP PY 2009 VL 10 IS 9 BP 849 EP 854 DI 10.1016/S1470-2045(09)70194-9 PG 6 WC Oncology SC Oncology GA 496EX UT WOS:000269953400013 PM 19664956 ER PT J AU Singh, J Im, J Whitten, JE Soares, JW Steeves, DM AF Singh, Jagdeep Im, Jisun Whitten, James E. Soares, Jason W. Steeves, Diane M. TI Encapsulation of Zinc Oxide Nanorods and Nanoparticles SO LANGMUIR LA English DT Article ID SELF-ASSEMBLED MONOLAYERS; ZNO NANOPARTICLES; SOLAR-CELLS; SURFACES; ADSORPTION; CO; NANOSTRUCTURES; SPECTROSCOPY; SENSORS; FILMS AB A simple method for encapsulating zinc oxide nanoparticles within an organic matrix is described that consists of dispersing them in an ethanolic solution, adding an organothiol, and stirring while heating. Electron microscopy, photoemission, Raman spectroscopy, and thermal gravimetric analyses demonstrate that partial dissolution of the oxide occurs, accompanied by encapsulation within a matrix consisting of a 1:2 zinc/thiol complex. Using this methodology, it is possible to surround ZnO within diverse matrices, including fluorescent ones. The process is demonstrated for 1-dodecanethiol (DDT) and fluorescent 2-naphthalenethiol (NPT). For DDT, ZnO nanorods become surrounded by a layer of the zinc-thiol complex that is greater than 100 angstrom thick. In the case of NPT, significantly greater dissolution of the ZnO occurs, with the encapsulated rods taking on a spherical geometry, its evidenced by electron microscopy. C1 [Singh, Jagdeep; Im, Jisun; Whitten, James E.] Univ Massachusetts Lowell, Dept Chem, Lowell, MA 01854 USA. [Singh, Jagdeep; Im, Jisun; Whitten, James E.] Univ Massachusetts Lowell, Ctr Adv Mat, Lowell, MA 01854 USA. [Singh, Jagdeep; Im, Jisun; Whitten, James E.] Univ Massachusetts Lowell, Ctr High Rate Nanomfg, Lowell, MA 01854 USA. [Soares, Jason W.; Steeves, Diane M.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Whitten, JE (reprint author), Univ Massachusetts Lowell, Dept Chem, Lowell, MA 01854 USA. EM James_Whitten@uml.edu; diane.steeves@us.army.mil FU U.S. Army Natick Soldier Research, Development & Engineering Center [W911NF-07-D-0001-0335 TCN 08047] FX The authors acknowledge Dr. Peter Stenhouse and Dr. Joel Carlson from the U.S. Army Natick Soldier Research. Development & Engineering Center for their assistance with characterization techniques. The authors also acknowledge Dr. Vasil Pajcini of Evans Analytical Group (EAG) for his help with the Raman spectroscopy measurements. A portion of this work Was Supported by the U.S. Army Natick Soldier Research, Development & Engineering Center under Contract No. W911NF-07-D-0001-0335 TCN 08047, This document has been approved for unlimited distribution (PAO No. U09-093). NR 35 TC 27 Z9 28 U1 1 U2 24 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD SEP 1 PY 2009 VL 25 IS 17 BP 9947 EP 9953 DI 10.1021/la9010983 PG 7 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 486LK UT WOS:000269197500046 PM 19705890 ER PT J AU Ott, M AF Ott, Martin TI Sugar, Wine, Smoke and Glue SO LITERARY REVIEW LA English DT Fiction, Creative Prose C1 USA, Washington, DC USA. RP Ott, M (reprint author), USA, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FAIRLEIGH DICKINSON UNIV LITERARY REV PI MADISON PA 285 MADISON AVE, MADISON, NJ 07940 USA SN 0024-4589 J9 LITERARY REV JI Lit. Rev. PD FAL PY 2009 VL 53 IS 1 BP 170 EP 174 PG 5 WC Literary Reviews SC Literature GA 541DL UT WOS:000273393400036 ER PT J AU Kim, SC Whitten, J Kumar, J Bruno, FF Samuelson, LA AF Kim, Seong-Cheol Whitten, James Kumar, Jayant Bruno, Ferdinando F. Samuelson, Lynne A. TI Self-doped Carboxylated Polyaniline: Effect of Hydrogen Bonding on the Doping of Polymers SO MACROMOLECULAR RESEARCH LA English DT Article DE self-doping; polyaniline; surfactant; H-bonding ID CONDUCTING POLYANILINE; SULFONATED POLYANILINE; ELECTRONIC-STRUCTURE; ACID; MONOLAYERS; POLYMERIZATION; NANOCOMPOSITES; EMERALDINE; MORPHOLOGY; MOLECULES AB This study examined the unique self-doping behavior of carboxylated polyaniline (PCA). The self-doped PCA was synthesized using an environmentally benign enzymatic polymerization method with cationic surfactants. XPS showed that HCl-doped PCA contained approximately 34% of protonated amines but self-doped PCA contained 9.6% of the doped form of nitrogen at pH 4. FTIR and elemental analysis showed that although the PCA was doped with the proton of strong acids at low pH via the protonation of amines, the self-doping mechanism of PCA at pH > 4 was mainly due to hydrogen bonding between the carboxylic acid group and amine group. C1 [Whitten, James; Kumar, Jayant] Univ Massachusetts Lowell, Dept Chem, Polymer Sci Program, Ctr Adv Mat, Lowell, MA 01854 USA. [Whitten, James; Kumar, Jayant] Univ Massachusetts Lowell, Dept Phys, Polymer Sci Program, Ctr Adv Mat, Lowell, MA 01854 USA. [Kim, Seong-Cheol] Yeungnam Univ, Sch Text, Gyeungsan 712749, Gyungbuk, South Korea. [Bruno, Ferdinando F.; Samuelson, Lynne A.] USA, Natick Soldier Dev & Engn Ctr, Natick, MA 01760 USA. RP Kumar, J (reprint author), Univ Massachusetts Lowell, Dept Chem, Polymer Sci Program, Ctr Adv Mat, Lowell, MA 01854 USA. EM Jayant_Kumar@uml.edu; Lynne_Samuelson@us.army.mil FU Yeungnam University FX This research was Supported by the Yeungnam University research grants in 2008. NR 51 TC 7 Z9 8 U1 3 U2 17 PU POLYMER SOC KOREA PI SEOUL PA ROOM 601, HATCHON BUILDING, 831 YEOKSAM-DONG, KANGNAM-KU, SEOUL 135-792, SOUTH KOREA SN 1598-5032 J9 MACROMOL RES JI Macromol. Res. PD SEP PY 2009 VL 17 IS 9 BP 631 EP 637 PG 7 WC Polymer Science SC Polymer Science GA 506JH UT WOS:000270770600001 ER PT J AU Kennedy, AJ Steevens, JA Lotufo, GR Farrar, JD Reiss, MR Kropp, RK Doi, J Bridges, TS AF Kennedy, Alan J. Steevens, Jeffery A. Lotufo, Guilherme R. Farrar, John D. Reiss, Mark R. Kropp, Roy K. Doi, Jon Bridges, Todd S. TI A comparison of acute and chronic toxicity methods for marine sediments SO MARINE ENVIRONMENTAL RESEARCH LA English DT Article DE Sediment toxicity; Bioassay; Chronic; Sublethal; Amphipod; Polychaete ID AMPHIPOD LEPTOCHEIRUS-PLUMULOSUS; ESTUARINE AMPHIPOD; FRESH-WATER; NEANTHES ARENACEODENTATA; RHEPOXYNIUS-ABRONIUS; QUALITY GUIDELINES; AMPELISCA-ABDITA; HYALELLA-AZTECA; TESTS; BIOASSAY AB Sediment toxicity tests are valuable tools for assessing the potential effects of contaminated sediments in dredged material evaluations because they inherently address complexity (e.g.. unknown contaminants, mixtures, bioavailability). Although there is a need to understand the chronic and sublethal impacts of contaminants, it is common to conduct only short-term lethality tests in evaluations of marine sediments. Chronic toxicity methods for marine sediments have been developed but the efficacy of these methods is less documented. In this evaluation of marine sediments collected from the New York/New Jersey (NY/NJ) Harbor, three 10-d acute toxicity test methods (Ampelisca abdita, Leptocheirus plumulosus, Americamysis bahia) and three chronic and sublethal test methods (28-d L plumulosus, 20- and 28-d Neanthes arenaceodentata) were applied by three testing laboratories. Although the N. arenaceodentata and A. bahia tests did not indicate significant toxicity for the sediments tested in this study, these methods have been reported useful in evaluating other sediments. The 10-d A. abdita, 10-d L. plumulosus and 28-d L plumulosus tests were comparable between laboratories, indicating 29-43%, 29%, and 43-71% of the tested sediments as potentially toxic. The 28-d L. plumulosus method was the only chronic toxicity test that responded to the test sediments in this study. The 28-d L plumulosus endpoint magnitudes were related to sediment chemistry and the sublethal endpoints were reduced as much or more than acute lethality endpoints. However, intra-treatment sublethal endpoint variability was greater, compromising detection of statistical significance. In this study, the chronic L plumulosus test method was less consistent among laboratories relative to acute test methods, identifying potential for toxicity in a similar number (or slightly more) NY/NJ Harbor sediments. Published by Elsevier Ltd. C1 [Kennedy, Alan J.; Steevens, Jeffery A.; Lotufo, Guilherme R.; Farrar, John D.; Bridges, Todd S.] USA, Engn Res & Dev Ctr, Environm Lab, CEERD EP R, Vicksburg, MS 39180 USA. [Reiss, Mark R.] US EPA, New York, NY 10007 USA. [Kropp, Roy K.] Marine Sci Lab, Battelle Pacific NW Div, Sequim, WA 98382 USA. [Doi, Jon] Aqua Survey Inc, Flemington, NJ 08822 USA. RP Kennedy, AJ (reprint author), USA, Engn Res & Dev Ctr, Environm Lab, CEERD EP R, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Alan.J.Kennedy@usace.army.mil FU US Army Corps of Engineers New York District; US Environmental Protection Agency FX We thank US Army Corps of Engineers New York District and the US Environmental Protection Agency for sponsoring this research. We thank Monte Greges, Oksana Yaremko (US ACE), Walter Berry (US EPA), and Ken Finkelstein (NOAA) and three anonymous reviewers for enhancing technical clarity. Mark Graves (US ACE) provided GIS mapping assistance. Analytical chemistry was completed by the analytical chemistry branch (Doug Taggert, Richard Karn, Anthony Bednar). We acknowledge support for the sediment collection effort by Mr. Tom Wyche (CENAN). Deb Clestreicher and Jen Chappell provided technical editing. Permission has been granted by the Chief of Engineers to publish this material. The work presented in this paper has been internally reviewed by US EPA, its publication however does not signify that the contents reflect the views of the Agency. NR 53 TC 15 Z9 15 U1 0 U2 20 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0141-1136 J9 MAR ENVIRON RES JI Mar. Environ. Res. PD SEP PY 2009 VL 68 IS 3 BP 118 EP 127 DI 10.1016/j.marenvres.2009.04.010 PG 10 WC Environmental Sciences; Marine & Freshwater Biology; Toxicology SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Toxicology GA 478UV UT WOS:000268614800003 PM 19481793 ER PT J AU Davis, AD AF Davis, Addison D. TI Munitions Discarded at Sea SO MARINE TECHNOLOGY SOCIETY JOURNAL LA Welsh DT Editorial Material C1 USA, Washington, DC 20310 USA. RP Davis, AD (reprint author), USA, Washington, DC 20310 USA. NR 0 TC 1 Z9 1 U1 0 U2 2 PU MARINE TECHNOLOGY SOC INC PI COLUMBIA PA 5565 STERRETT PLACE, STE 108, COLUMBIA, MD 21044 USA SN 0025-3324 J9 MAR TECHNOL SOC J JI Mar. Technol. Soc. J. PD FAL PY 2009 VL 43 IS 4 BP 11 EP 13 PG 3 WC Engineering, Ocean; Oceanography SC Engineering; Oceanography GA 523VK UT WOS:000272102500003 ER PT J AU Shen, Q Al-Smadi, YM Martin, PJ Russell, K Sodhi, RS AF Shen, Qiong Al-Smadi, Yahia M. Martin, Peter J. Russell, Kevin Sodhi, Raj S. TI An extension of mechanism design optimization for motion generation SO MECHANISM AND MACHINE THEORY LA English DT Article DE Motion generation; Coupler load; Planar mechanism; Four-bar mechanism; Optimization; Selection algorithm ID 4-BAR LINKAGE; PLANAR AB As an extension of the authors published work on a search algorithm for motion generation with Grashof, transmission angle and linkage perimeter conditions [P.J. Martin, K. Russell, R.S. Sodhi, On mechanism design optimization for motion generation, Mechanism and Machine Theory 42 (10) (2007) 1251-1263], this work formulates a goal program to generate four-bar mechanism fixed and moving pivot loci that considers prescribed coupler poses, a coupler load and maximum driver static torques. Published by Elsevier Ltd. C1 [Martin, Peter J.; Russell, Kevin] USA, Ctr Res Dev & Engn, Armaments Engn & Technol Ctr, Picatinny Arsenal, NJ 07806 USA. [Shen, Qiong; Sodhi, Raj S.] New Jersey Inst Technol, Dept Mech Engn, Newark, NJ 07102 USA. [Al-Smadi, Yahia M.] AECOM, Special Struct Grp, New York, NY 10005 USA. RP Russell, K (reprint author), USA, Ctr Res Dev & Engn, Armaments Engn & Technol Ctr, Picatinny Arsenal, NJ 07806 USA. EM kevin.russell1@us.army.mil RI Shen, Qiong/N-4015-2013 NR 14 TC 18 Z9 18 U1 1 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0094-114X J9 MECH MACH THEORY JI Mech. Mach. Theory PD SEP PY 2009 VL 44 IS 9 BP 1759 EP 1767 DI 10.1016/j.mechmachtheory.2009.03.001 PG 9 WC Engineering, Mechanical SC Engineering GA 457QR UT WOS:000266947700012 ER PT J AU Motoki, MT Wilkerson, RC Sallum, MAM AF Motoki, Maysa Tiemi Wilkerson, Richard C. Mureb Sallum, Maria Anice TI The Anopheles albitarsis complex with the recognition of Anopheles oryzalimnetes Wilkerson and Motoki, n. sp and Anopheles janconnae Wilkerson and Sallum, n. sp (Diptera: Culicidae) SO MEMORIAS DO INSTITUTO OSWALDO CRUZ LA English DT Article DE systematics; Nyssorhynchus; Anopheles albitarsis complex; new species; multivariate analysis ID POLYMERASE-CHAIN-REACTION; NYSSORHYNCHUS ALBITARSIS; PLASMODIUM-VIVAX; MALARIA VECTORS; COMPARATIVE SUSCEPTIBILITY; MARAJOARA GALVAO; WEST-INDIES; BRAZIL; MOSQUITOS; STATE AB The Anopheles (Nyssorhynchus) albitarsis complex includes six species: An. albitarsis, Anopheles oryzalimnetes Wilkerson and Motoki, n. sp., Anopheles marajoara, Anopheles deaneorum, Anopheles janconnae Wilkerson and Sallum, n. sp. and An. albitarsis F. Except for An. deaneorum, species of the complex are indistinguishable when only using morphology. The problematic distinction among species of the complex has made study of malaria transmission and ecology of An. albitarsis s.l. difficult. Consequently, involvement of species of the An. albitarsis complex in human Plasmodium transmission is not clear throughout its distribution range. With the aim of clarifying the taxonomy of the above species, with the exception of An. albitarsis F, we present comparative morphological and morphometric analyses, morphological redescriptions of three species and description of two new species using individuals from populations in Brazil, Paraguay, Argentina and Venezuela. The study included characters from adult females, males, fourth-instar larvae, pupae and male genitalia of An. albitarsis, An. marajoara, An. deaneorum and An. oryzalimnetes n. sp. For An. janconnae n. sp. only characters of the female, male and male genitalia were analyzed. Fourth-instar larvae, pupae and male genitalia characteristics of all five species are illustrated. Bionomics and distribution data are given based on published literature records. C1 [Motoki, Maysa Tiemi; Mureb Sallum, Maria Anice] Univ Sao Paulo, Fac Saude Publ, Dept Epidemiol, BR-01246904 Sao Paulo, Brazil. [Wilkerson, Richard C.] Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD USA. RP Sallum, MAM (reprint author), Univ Sao Paulo, Fac Saude Publ, Dept Epidemiol, BR-01246904 Sao Paulo, Brazil. EM masallum@usp.br RI Sallum, Maria/B-8537-2012 FU FAPESP [05/53973-0, 2007/07573-5]; CNPq [472485/2006-7]; NIH [AI RO154139] FX Financial support: FAPESP (05/53973-0 to MAMS), CNPq (472485/2006-7 to MAMS), NIH (AI RO154139 to JE Conn). MTM is a doctorate fellow from Fapesp (2007/07573-5). NR 71 TC 26 Z9 26 U1 0 U2 2 PU FUNDACO OSWALDO CRUZ PI RIO DE JANEIRO, RJ PA AV BRASIL 4365, 21045-900 RIO DE JANEIRO, RJ, BRAZIL SN 0074-0276 J9 MEM I OSWALDO CRUZ JI Mem. Inst. Oswaldo Cruz PD SEP PY 2009 VL 104 IS 6 BP 823 EP 850 PG 28 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA 514VT UT WOS:000271424800004 PM 19876554 ER PT J AU Welton, MD AF Welton, Mark D. TI Shari'a: Theory, Practice, Transformations SO MIDDLE EAST JOURNAL LA English DT Book Review C1 [Welton, Mark D.] US Mil Acad, West Point, NY 10996 USA. RP Welton, MD (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU MIDDLE EAST INST PI WASHINGTON PA 1761 N ST NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 USA SN 0026-3141 EI 1940-3461 J9 MIDDLE EAST J JI Middle East J. PD FAL PY 2009 VL 63 IS 4 BP 681 EP 682 PG 2 WC Area Studies SC Area Studies GA 515BQ UT WOS:000271441700021 ER PT J AU Root, SM AF Root, Sara M. TI CAPITALIZING "F" IS NOT ENOUGH: THE ARMY SHOULD REVISE ITS POSTPARTUM LEAVE POLICIES TO BETTER SUPPORT THE ARMY FAMILY SO MILITARY LAW REVIEW LA English DT Article ID CHILD DAY-CARE; MATERNAL EMPLOYMENT; PARENTAL LEAVE; HEALTH; SIBLINGS; ILLNESS; MOTHER; LENGTH; WOMEN; TIME C1 [Root, Sara M.] USA, Washington, DC USA. [Root, Sara M.] Multinatl Corps Iraq, Airborne Corps 18, Baghdad, Iraq. [Root, Sara M.] XVIII Airborne Corps, Ft Bragg, NC USA. [Root, Sara M.] 82D Airborne Div, Ft Bragg, NC USA. [Root, Sara M.] 10th Mt Div, Tuzla, Bosnia & Herceg. [Root, Sara M.] 101st Airborne Div Air Assault, Ft Campbell, KY USA. RP Root, SM (reprint author), Govt Appellate Div, Arlington, VA USA. NR 59 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 2009 VL 201 BP 132 EP 183 PG 52 WC Law SC Government & Law GA 539EW UT WOS:000273237400003 ER PT J AU Brown, BW AF Brown, Bailey W., III TI DON'T ASK, DO TELL: THE IMPLICATIONS OF 2008 CIRCUIT COURT DECISIONS FOR THE STANDARD OF CONSTITUTIONAL REVIEW APPLICABLE TO THE MILITARY HOMOSEXUAL CONDUCT POLICY SO MILITARY LAW REVIEW LA English DT Article C1 [Brown, Bailey W., III] USA, Washington, DC USA. [Brown, Bailey W., III] 501st Sustainment Brigade, Taegu, South Korea. [Brown, Bailey W., III] 18th Engineer Brigade Theater Army, Bagram, Afghanistan. [Brown, Bailey W., III] US Army So European Task Force SETAF Airborne, Vicenza, Italy. RP Brown, BW (reprint author), USA Garrison, Ft Mcpherson, GA USA. NR 16 TC 1 Z9 1 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 2009 VL 201 BP 184 EP 236 PG 53 WC Law SC Government & Law GA 539EW UT WOS:000273237400004 ER PT J AU O'Neill, MD AF O'Neill, Michael D. TI SWAY: THE IRRESISTIBLE PULL OF IRRATIONAL BEHAVIOR SO MILITARY LAW REVIEW LA English DT Book Review C1 [O'Neill, Michael D.] USA, Washington, DC 20310 USA. RP O'Neill, MD (reprint author), USA, Washington, DC 20310 USA. NR 7 TC 0 Z9 0 U1 0 U2 2 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 2009 VL 201 BP 262 EP 270 PG 9 WC Law SC Government & Law GA 539EW UT WOS:000273237400006 ER PT J AU Fuenfer, MM Spinella, PC Naclerio, AL Creamer, KM AF Fuenfer, Michael M. Spinella, Philip C. Naclerio, Anne L. Creamer, Kevin M. TI The US Military Wartime Pediatric Trauma Mission: How Surgeons and Pediatricians are Adapting the System to Address the Need SO MILITARY MEDICINE LA English DT Article ID IRAQ; AFGHANISTAN; EXPERIENCE; CHILDREN AB Purpose: Over 3,500 infants and children, many critically ill and injured, have been admitted to military combat support hospitals (CSH) in Afghanistan and Iraq, which are not doctrinally staffed or equipped to provide their care. This report details how the military medical system is adapting to create a data driven and comprehensive response to optimize the medical and surgical pediatric care being provided. Methods: Information from multiple sources was used over time to craft the military medical response to the pediatric wartime mission. Pediatric data from both the Joint Theater Trauma Registry (JTTR) and the Patient Administration Systems and Biostatistics Activity (PASHA) database were utilized extensively. The resulting educational, supply, and personnel adaptations implemented by the U.S. military will be highlighted, and innovations currently under development will also be described on the basis of this demonstrated need. Results: This information helped drive pediatric-specific, just-in-time education for CSH personnel, modified CSH equipment and supply lists, inspired the 24/7 pediatric critical care teleconsultation service, and resulted in new initiatives in the predeployment training for CSH personnel. Conclusion: Military physicians are routinely asked to perform outside their traditional scopes of practice while deployed. Given this reality, military pediatric specialists in medicine and surgery have initiated several successful multidisciplinary programs designed to improve in-theater care of injured children. These innovative efforts include drafting a pediatric addendum to the Army's "Emergency War Surgery" manual, development of instructional compact discs, augmenting and refining the pediatric portion of the Joint Forces Combat Trauma Management course, formation of a pediatric augmentation team to the CSH. and a comprehensive hyperlinked Web-based pediatric critical care and trauma educational platform. C1 [Fuenfer, Michael M.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Creamer, Kevin M.] Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Spinella, Philip C.] Connecticut Childrens Med Ctr, Div Crit Care, Dept Pediat, Hartford, CT USA. [Naclerio, Anne L.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. RP Fuenfer, MM (reprint author), Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. NR 15 TC 12 Z9 12 U1 0 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 2009 VL 174 IS 9 BP 887 EP 891 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 601LH UT WOS:000278060400001 PM 19780362 ER PT J AU Kaspar, RL Griffith, ME Mann, PB Lehman, DJ Conger, NG Hospenthal, DR Murray, CK AF Kaspar, Robert L. Griffith, Matthew E. Mann, Paul B. Lehman, Devon J. Conger, Nicholas G. Hospenthal, Duane R. Murray, Clinton K. TI Association of Bacterial Colonization at the Time of Presentation to a Combat Support Hospital in a Combat Zone With Subsequent 30-Day Colonization or Infection SO MILITARY MEDICINE LA English DT Article ID US ARMY SOLDIERS; ACINETOBACTER-BAUMANNII; IRAQ; OPERATIONS AB U.S. casualties have developed multidrug-resistant (MDR) bacterial infections. A surveillance project to evaluate U.S. military patients for the presence of MDR pathogens from wounding through the first 30 days of care in the military healthcare system (MHS) was performed. U.S. military patients admitted to a single combat support hospital in Iraq during June-July of 2007 had screening swabs obtained for the detection of MDR bacteria and a subsequent retrospective electronic medical records review for presence of colonization or infection in the subsequent 30 days. Screening of 74 U.S. military patients in Iraq found one colonized with methicillin-resistant Staphylococcus aureus. Fifty-six patients of these were screened for Acinetobacter in Germany and one found colonized. Of patients evacuated to the U.S., 9 developed infections. Carefully obtained screening cultures immediately after injury combined with look-back monitoring supports the role of nosocomial transmission. Consistent infection control strategies are needed for the entire MHS. C1 [Kaspar, Robert L.] Darnall Army Med Ctr, Dept Med, Ft Hood, TX USA. [Griffith, Matthew E.; Hospenthal, Duane R.; Murray, Clinton K.] San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX USA. [Griffith, Matthew E.; Hospenthal, Duane R.; Murray, Clinton K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Mann, Paul B.] USA, Med Dept Ctr, Ft Sam Houston, TX USA. [Mann, Paul B.] USA, Med Dept Sch, Ft Sam Houston, TX USA. [Lehman, Devon J.] Brooke Army Med Ctr, Dept Nursing, Ft Sam Houston, TX 78234 USA. [Conger, Nicholas G.] Landstuhl Reg Med Ctr, Dept Infect Dis, Landstuhl, Germany. RP Kaspar, RL (reprint author), Darnall Army Med Ctr, Dept Med, Ft Hood, TX USA. NR 12 TC 16 Z9 16 U1 2 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 2009 VL 174 IS 9 BP 899 EP 903 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 601LH UT WOS:000278060400003 PM 19780364 ER PT J AU Coleman, RE Hochberg, LP Putnam, JL Swanson, KI Lee, JS McAvin, JC Chan, AS O'Guinn, ML Ryan, JR Wirtz, RA Moulton, JK Dave, K Faulde, MK AF Coleman, Russell E. Hochberg, Lisa P. Putnam, John L. Swanson, Katherine I. Lee, John S. McAvin, James C. Chan, Adeline S. O'Guinn, Monica L. Ryan, Jeffry R. Wirtz, Robert A. Moulton, John K. Dave, Kirti Faulde, Michael K. TI Use of Vector Diagnostics During Military Deployments: Recent Experience in Iraq and Afghanistan SO MILITARY MEDICINE LA English DT Article ID WEST-NILE-VIRUS; POLYMERASE-CHAIN-REACTION; PHLEBOTOMINE SAND FLIES; ANTIGEN PANEL ASSAY; TALLIL AIR BASE; PLASMODIUM-FALCIPARUM; RAPID DETECTION; ANOPHELINE MOSQUITOS; INDIVIDUAL MOSQUITOS; INFECTIOUS-DISEASES AB Vector-borne diseases such as malaria, dengue, and leishmaniasis are a threat to military forces deployed outside of the United States. The availability of specific information on the vector-borne disease threat (e.g., presence or absence of a specific disease agent, temporal and geographic distribution of competent vectors, and vector infection rates) allows or effective implementation of appropriate measures to protect our deployed military forces. Vector diagnostics can provide critical, real-time information crucial to establishing effective vector prevention/control programs. In this article we provide an overview of current vector diagnostic capabilities, evaluate the use of vector diagnostics in Operation Enduring Freedom and Operation Iraqi Freedom, and discuss the concept of operations under which vector diagnostics are employed. C1 [Coleman, Russell E.; Hochberg, Lisa P.; Swanson, Katherine I.; Chan, Adeline S.; Ryan, Jeffry R.] Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD USA. [Putnam, John L.; McAvin, James C.] USAF, Inst Operat Hlth, Epidemiol Surveillance Div, San Antonio, TX USA. [Lee, John S.; O'Guinn, Monica L.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Wirtz, Robert A.] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vectorborne & Enter Dis, Atlanta, GA USA. [Dave, Kirti] VecTOR Test Syst Inc, Thousand Oaks, CA USA. [Moulton, John K.] Univ Tennessee, Dept Entomol & Plant Pathol, Knoxville, TN 37901 USA. [Faulde, Michael K.] Cent Inst Bundeswehr Med Serv, Dept Med Zool, Koblenz, Germany. RP Coleman, RE (reprint author), Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD USA. FU Military Infectious Diseases Research Program; Armed Forces Medical Intelligence Center; Deployed War-Fighter Protection Program FX Funding for this project was provided by the Military Infectious Diseases Research Program, the Armed Forces Medical Intelligence Center, and the Deployed War-Fighter Protection Program. Many thanks to LTC Bill Sames for his review of this manuscript, and to LTC (Ret.) Richard Lofts. COL David Craft, and Dr. Michael Turell for their guidance on BSATs. This study would not have been possible without the support of the many entomologists and environmental science officers conducting vector surveillance throughout Iraq and Afghanistan. In addition, the superb support of our laboratory technicians running the PCR assays is greatly appreciated-thanks to Wayne and Lara Gilmore, Monzia Moodie, Cathy Westbrook, and SGT Ronald Hadley. NR 74 TC 7 Z9 7 U1 0 U2 5 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 2009 VL 174 IS 9 BP 904 EP 920 PG 17 WC Medicine, General & Internal SC General & Internal Medicine GA 601LH UT WOS:000278060400004 PM 19780365 ER PT J AU Wisor, R AF Wisor, Rebecca TI Versioning Virginia Woolf: Notes toward a Post-eclectic Edition of Three Guineas SO MODERNISM-MODERNITY LA English DT Article C1 US Mil Acad, West Point, NY 10996 USA. RP Wisor, R (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 36 TC 2 Z9 2 U1 0 U2 0 PU JOHNS HOPKINS UNIV PRESS PI BALTIMORE PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD 21218-4363 USA SN 1071-6068 J9 MODERNISM-MODERNITY JI Mod.-Mod. PD SEP PY 2009 VL 16 IS 3 BP 497 EP 535 PG 39 WC Humanities, Multidisciplinary SC Arts & Humanities - Other Topics GA 502BJ UT WOS:000270428700010 ER PT J AU Chilukuri, N Duysen, EG Parikh, K diTargiani, R Doctor, BP Lockridge, O Saxena, A AF Chilukuri, Nageswararao Duysen, Ellen G. Parikh, Kalpana diTargiani, Robert Doctor, Bhupendra P. Lockridge, Oksana Saxena, Ashima TI Adenovirus-Transduced Human Butyrylcholinesterase in Mouse Blood Functions as a Bioscavenger of Chemical Warfare Nerve Agents SO MOLECULAR PHARMACOLOGY LA English DT Article ID RECOMBINANT HUMAN BUTYRYLCHOLINESTERASE; HUMAN SERUM BUTYRYLCHOLINESTERASE; HUMORAL IMMUNE-RESPONSES; GENE-TRANSFER; IN-VIVO; CIRCULATORY STABILITY; GUINEA-PIGS; TOXICITY; MICE; PROTECTION AB Human serum butyrylcholinesterase (Hu BChE) is a promising therapeutic against the toxicity of chemical warfare nerve agents. We have showed previously that recombinant (r) Hu BChE can be expressed at very high levels, 400 to 600 U/ml in mouse blood, by delivering the Hu BChE gene using adenovirus (Ad). Here, we report the biochemical properties of the Ad-expressed full-length and truncated rHu BChE in mouse blood. The molecular sizes of the full-length rHu BChE subunit and its oligomers were similar to those of native Hu BChE, although only a small portion of the full-length rHu BChE subunit underwent assembly into dimers and tetramers. As expected, Ad containing the truncated Hu BChE gene transduced the expression of monomeric rHu BChE only. Compared with 415 U of rHu BChE per milliliter in blood, tissues including liver, lung, heart, brain, kidney, muscle, intestine, diaphragm, salivary gland, and fat expressed <10 U/g of rHu BChE activity. Ad-expressed rHu BChE in mouse blood neutralized soman and O-ethyl S-2-N,N-diisopropylaminoethyl methylphosphonothiolate at rates similar to those of native Hu BChE and rHu BChE expressed in vitro. Because the expression of rHu BChE rapidly decreased 6 days after virus administration, sera were assayed for the presence of anti-Hu BChE antibodies. Anti-Hu BChE antibodies were detected on day 7 and in increased amounts thereafter, which coincided with the loss of Hu BChE expression in sera. In conclusion, the delivery of Hu BChE gene using Ad can be a promising strategy that can provide protection against multiple lethal doses of chemical warfare nerve agents in vivo. C1 [Chilukuri, Nageswararao] Walter Reed Army Inst Res, Dept Mol Pharmacol, Div Biochem, Silver Spring, MD 20910 USA. [Duysen, Ellen G.; Lockridge, Oksana] Univ Nebraska Med Ctr, Eppley Inst, Omaha, NE USA. RP Chilukuri, N (reprint author), Walter Reed Army Inst Res, Dept Mol Pharmacol, Div Biochem, Silver Spring, MD 20910 USA. EM nageswararao.chilukuri@us.army.mil RI diTargiani, Robert/B-6484-2009; OI Duysen, Ellen/0000-0002-0128-9032 FU U.S. Department of Defense Defense Threat Reduction Agency [1.D0003_05_WR_C] FX This work was supported by the U.S. Department of Defense Defense Threat Reduction Agency [Grant 1.D0003_05_WR_C]. NR 38 TC 5 Z9 6 U1 0 U2 3 PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA SN 0026-895X J9 MOL PHARMACOL JI Mol. Pharmacol. PD SEP PY 2009 VL 76 IS 3 BP 612 EP 617 DI 10.1124/mol.109.055665 PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 485YO UT WOS:000269162500017 PM 19542320 ER PT J AU Muralt, P Polcawich, RG Trolier-McKinstry, S AF Muralt, P. Polcawich, R. G. Trolier-McKinstry, S. TI Piezoelectric Thin Films for Sensors, Actuators, and Energy Harvesting SO MRS BULLETIN LA English DT Article ID LEAD-ZIRCONATE-TITANATE; BULK ACOUSTIC RESONATORS; ULTRASOUND TRANSDUCERS; DEFORMABLE MIRROR; PZT; MEMS; DEPOSITION; PERFORMANCE; FABRICATION; DEPENDENCE AB Piezoelectric microelectromechanical systems (MEMS) offer the opportunity for high-sensitivity sensors and large displacement, low-voltage actuators. In particular, recent advances in the deposition of perovskite thin films point to a generation of MEMS devices capable of large displacements at complementary metal oxide semiconductor-compatible voltage levels. Moreover, if the devices are mounted in mechanically noisy environments, they also can be used for energy harvesting. Key to all of these applications is the ability to obtain high piezoelectric coefficients and retain these coefficients throughout the microfabrication process. This article will review the impact of composition, orientation, and microstructure on the piezoelectric properties of perovskite thin films such as PbZr1-xTixO3 (PZT). Superior piezoelectric coefficients (e(31,f) of -18 C/m(2)) are achieved in {001}-oriented PbZr0.52Ti0.48O3 films with improved compositional homogeneity on Si substrates. The advent of such high piezoelectric responses in films opens up a wide variety of possible applications. A few examples of these, including low-voltage radio frequency MEMS switches and resonators, actuators for millimeter-scale robotics, droplet ejectors, energy scavengers for unattended sensors, and medical imaging transducers, will be discussed. C1 [Muralt, P.] Swiss Fed Inst Technol, Zurich, Switzerland. [Polcawich, R. G.] USA, Res Lab, Adelphi, MD 20783 USA. [Trolier-McKinstry, S.] Penn State Univ, University Pk, PA 16802 USA. RP Muralt, P (reprint author), Swiss Fed Inst Technol, Zurich, Switzerland. EM paul.muralt@epfl.ch; ronald.g.polcawich@us.army.mil; STMcKinstry@psu.edu RI Muralt, Paul/C-5351-2008; OI Muralt, Paul/0000-0001-6004-1208; Trolier-McKinstry, Susan/0000-0002-7267-9281 FU NSSEFF; NSF; Ben Franklin Technology PArtners; Center for Dielectric Studies; ARC; DARPA; Materials Research Institute FX The authors would like to acknowledge the MEMS Group at the U.S. Army Research Laboratory, along with Sunil Bhave and Hengky Chandrahalim of Cornell University. STM gratefully acknowledges funding from an NSSEFF fellowship, NSF, Ben Franklin Technology PArtners, the Center for Dielectric Studies, ARC, DARPA, and the Materials Research Institute. She also thankfully acknowledges her many group members, collaborators, and colleagues. NR 75 TC 86 Z9 87 U1 16 U2 126 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0883-7694 EI 1938-1425 J9 MRS BULL JI MRS Bull. PD SEP PY 2009 VL 34 IS 9 BP 658 EP 664 DI 10.1557/mrs2009.177 PG 7 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA 493WA UT WOS:000269768100017 ER PT J AU Pallone, AK Demaree, JD AF Pallone, A. K. Demaree, J. D. TI CASSPERR: A gamma-gamma cascade detector for resonant nuclear reaction analysis SO NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS LA English DT Article DE Nuclear reaction analysis; Gamma cascade; Coincidence spectrometer ID NEUTRON-ACTIVATION ANALYSIS; COINCIDENCE SPECTROMETER; RAY SPECTROSCOPY; ALUMINUM OXYNITRIDE; PGNAA APPLICATIONS; SYSTEM; CHLORINE; HYDROGEN; SPECTRA; PGAA AB Resonant nuclear reaction analysis (RNRA) is sometimes the only technique able to quantify elements in a matrix containing other elements. Background due to cosmic rays and natural radioactivity has limited traditional RNRA to samples with relatively high concentrations of the measured element, or to facilities with large amounts of passive shielding. Many nuclear reactions of interest in RNRA produce excited states in the resulting nuclei that then de-excite by product-specific sequences of photon emissions. The CAScade SPEctrometer for Resonant Reactions (CASSPERR) selects only events that match the desired combination of photon emissions. Rejection of other events greatly reduces the background, thus improving the signal to noise ratio (SNR). Since it is constructed from available commercial components, CASSPERR opens RNRA to typical ion beam analysis facilities. The design, operation and evaluation of CASSPERR with applications to materials science are currently under investigation. (C) 2009 Elsevier B.V. All rights reserved. C1 [Pallone, A. K.] Murray State Univ, Dept Engn & Phys, Murray, KY 42071 USA. [Demaree, J. D.] USA, Res Lab, WMRD, Aberdeen Proving Ground, MD 21005 USA. RP Pallone, AK (reprint author), Murray State Univ, Dept Engn & Phys, Murray, KY 42071 USA. EM art.pallone@murraystate.edu FU National Science Foundation FX This work was supported in part by the National Science Foundation through the Kentucky EPSCoR National Laboratory initiative program. NR 43 TC 0 Z9 0 U1 1 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-583X J9 NUCL INSTRUM METH B JI Nucl. Instrum. Methods Phys. Res. Sect. B-Beam Interact. Mater. Atoms PD SEP 1 PY 2009 VL 267 IS 17 BP 2927 EP 2933 DI 10.1016/j.nimb.2009.05.066 PG 7 WC Instruments & Instrumentation; Nuclear Science & Technology; Physics, Atomic, Molecular & Chemical; Physics, Nuclear SC Instruments & Instrumentation; Nuclear Science & Technology; Physics GA 498RU UT WOS:000270161600021 ER PT J AU Hrozhyk, U Nersisyan, S Serak, S Tabiryan, N Hoke, L Steeves, DM Kimball, BR AF Hrozhyk, Uladzimir Nersisyan, Sarik Serak, Svetlana Tabiryan, Nelson Hoke, Landa Steeves, Diane M. Kimball, Brian R. TI Optical switching of liquid-crystal polarization gratings with nanosecond pulses SO OPTICS LETTERS LA English DT Article ID EFFICIENCY AB Optical switching with single nanosecond laser pulses of 532 nm wavelength is reported using high-efficiency optical axis gratings made with a nematic liquid crystal doped with an azobenzene dye. The azobenzene dye we have synthesized exhibits enhanced photosensitivity at green wavelengths, allowing for low threshold switching (similar to 10 mJ/cm(2)). The dye is also characterized by fast relaxation of isomers, allowing for restoration of the diffractive properties of the grating within similar to 100 ms. Change of the diffraction efficiency of the zeroth-order beam from 10% to 70% is observed in a micrometer-thick material layer. (C) 2009 Optical Society of America. C1 [Hoke, Landa; Steeves, Diane M.; Kimball, Brian R.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. [Hrozhyk, Uladzimir; Nersisyan, Sarik; Serak, Svetlana; Tabiryan, Nelson] Beam Engn Adv Measurements Co, Winter Pk, FL 32789 USA. RP Kimball, BR (reprint author), USA, Natick Soldier Res Dev & Engn Ctr, Kansas St, Natick, MA 01760 USA. EM Brian.R.Kimball@us.army.mil FU NSRDEC [U09-233] FX This document has been approved for public release. NSRDEC PAO # U09-233. NR 12 TC 11 Z9 11 U1 1 U2 7 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD SEP 1 PY 2009 VL 34 IS 17 BP 2554 EP 2556 PG 3 WC Optics SC Optics GA 498CO UT WOS:000270114400004 PM 19724487 ER PT J AU Schwartz, SR Cohen, SM Dailey, SH Rosenfeld, RM Deutsch, ES Gillespie, MB Granieri, E Hapner, ER Kimball, CE Krouse, HJ McMurray, JS Medina, S O'Brien, K Ouellette, DR Messinger-Rapport, BJ Stachler, RJ Strode, S Thompson, DM Stemple, JC Willging, JP Cowley, T Mccoy, S Bernad, PG Patel, MM AF Schwartz, Seth R. Cohen, Seth M. Dailey, Seth H. Rosenfeld, Richard M. Deutsch, Ellen S. Gillespie, M. Boyd Granieri, Evelyn Hapner, Edie R. Kimball, C. Eve Krouse, Helene J. McMurray, J. Scott Medina, Safdar O'Brien, Karen Ouellette, Daniel R. Messinger-Rapport, Barbara J. Stachler, Robert J. Strode, Steven Thompson, Dana M. Stemple, Joseph C. Willging, J. Paul Cowley, Terrie McCoy, Scott Bernad, Peter G. Patel, Milesh M. TI Clinical practice guideline: Hoarseness (Dysphonia) SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Review ID VOCAL FOLD PARALYSIS; ADDUCTOR SPASMODIC DYSPHONIA; QUALITY-OF-LIFE; COMMUNITY-ACQUIRED PNEUMONIA; GASTROESOPHAGEAL-REFLUX DISEASE; RECURRENT LARYNGEAL NERVE; BOTULINUM TOXIN THERAPY; ANTERIOR CERVICAL DISKECTOMY; CHRONIC POSTERIOR LARYNGITIS; ACID-SUPPRESSIVE THERAPY AB OBJECTIVE: This guideline provides evidence-based recommendations on managing hoarseness (dysphonia), defined as a disorder characterized by altered vocal quality, pitch, loudness, or vocal effort that impairs communication or reduces voice-related quality of life (QOL). Hoarseness affects nearly one-third of the population at some point in their lives. This guideline applies to all age groups evaluated in a setting where hoarseness would be identified or managed. It is intended for all clinicians who are likely to diagnose and manage patients with hoarseness. PURPOSE: The primary purpose of this guideline is to improve diagnostic accuracy for hoarseness (dysphonia), reduce inappropriate antibiotic use, reduce inappropriate steroid use, reduce inappropriate use of anti-reflux medications, reduce inappropriate use of radiographic imaging, and promote appropriate use of laryngoscopy, voice therapy, and surgery. In creating this guideline the American Academy of Otolaryngology-Head and Neck Surgery Foundation selected a panel representing the fields of neurology, speech-language pathology, professional voice teaching, family medicine, pulmonology, geriatric medicine, nursing, internal medicine, otolaryngology-head and neck surgery, pediatrics, and consumers. RESULTS: The panel made strong recommendations that 1) the clinician should not routinely prescribe antibiotics to treat hoarseness and 2) the clinician should advocate voice therapy for patients diagnosed with hoarseness that reduces voice-related QOL. The panel made recommendations that I) the clinician should diagnose hoarseness (dysphonia) in a patient with altered voice quality, pitch, loudness, or vocal effort that impairs communication or reduces voice-related QOL; 2) the clinician should assess the patient with hoarseness by history and/or physical examination for factors that modify management, Such as one or more of the following: recent surgical procedures involving the neck or affecting the recurrent laryngeal nerve, recent endotracheal intubation. radiation treatment to the neck, a history of tobacco abuse, and occupation as a singer or vocal performer; 3) the clinician should Visualize the patient's larynx, or refer the patient to a clinician who can visualize the larynx, when hoarseness fails to resolve by a maximum of three months after onset, or irrespective of duration if a serious underlying cause is Suspected; 4) the clinician should not obtain Computed tomography or magnetic resonance imaging of the patient with a primary complaint of hoarseness prior to visualizing the larynx; 5) the clinician should not prescribe anti-reflux medications for patients with hoarseness without signs or symptoms of gastroesophageal reflux disease; 6) the clinician should not routinely prescribe oral corticosteroids to treat hoarseness; 7) the clinician should Visualize the larynx before prescribing voice therapy and document/communicate the results to the speech-language pathologists and 8) the clinician should prescribe, or refer the patient to a clinician who can prescribe, botulinum toxin injections for the treatment of hoarseness caused by adductor spasmodic dysphonia. The panel offered as options that 1) the clinician may perform laryngoscopy at any time in a patient with hoarseness, or may refer the patient to a clinician who can visualize the larynx; 2) the clinician may prescribe anti-reflux medication for patients with hoarseness and signs of chronic laryngitis; and 3) the clinician may educate/counsel patients with hoarseness about control/preventive measures. DISCLAIMER: This clinical practice guideline is not intended as a sole source of guidance in managing hoarseness (dysphonia). Rather, it is designed to assist clinicians by providing an evidence-based framework for decision-making strategies. The guideline is not intended to replace clinical judgment or establish a protocol for all individuals with this condition, and may not provide the only appropriate approach to diagnosing and managing this problem. (C) 2009 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved. C1 [Schwartz, Seth R.] Virginia Mason Med Ctr, Seattle, WA 98111 USA. [Cohen, Seth M.] Duke Univ, Sch Med, Durham, NC USA. [Dailey, Seth H.; McMurray, J. Scott] Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI USA. [Rosenfeld, Richard M.] SUNY Downstate Med Coll, Brooklyn, NY USA. [Rosenfeld, Richard M.] Long Isl Coll Hosp, Brooklyn, NY 11201 USA. [Deutsch, Ellen S.] Alfred I DuPont Hosp Children, Wilmington, DE USA. [Gillespie, M. Boyd] Med Univ S Carolina, Charleston, SC 29425 USA. [Granieri, Evelyn] Columbia Univ, Coll Phys & Surg, New York, NY USA. [Hapner, Edie R.] Emory Voice Ctr, Atlanta, GA USA. [Kimball, C. Eve] All Children Pediat Partners PC, Reading, PA USA. [Krouse, Helene J.] Wayne State Univ, Detroit, MI USA. [Medina, Safdar] Univ Massachusetts, Sch Med, Uxbridge, MA USA. [O'Brien, Karen] US Army Training & Doctrine Command, Ft Monroe, VA USA. [Ouellette, Daniel R.] Henry Ford Hosp, Detroit, MI 48202 USA. [Messinger-Rapport, Barbara J.] Cleveland Clin, Cleveland, OH 44106 USA. [Stachler, Robert J.] Henry Ford Med Grp, Detroit, MI USA. [Strode, Steven] Univ Arkansas Med Sci, Little Rock, AR 72205 USA. [Thompson, Dana M.] Mayo Clin, Rochester, MN USA. [Stemple, Joseph C.] Univ Kentucky, Coll Hlth Sci, Lexington, KY USA. [Willging, J. Paul] Cincinnati Childrens Hosp, Med Ctr, Cincinnati, OH USA. [Cowley, Terrie] TMJ Assoc, Milwaukee, WI USA. [McCoy, Scott] Rider Univ, Westminster Choir Coll, Princeton, NJ USA. [Bernad, Peter G.] Metropolitan Med Ctr, Washington, DC USA. [Patel, Milesh M.] Amer Acad Otolaryngol Head & Neck Surg, Alexandria, VA USA. RP Schwartz, SR (reprint author), Virginia Mason Med Ctr, 1100 9th Ave,MS X10-ON,Box 900, Seattle, WA 98111 USA. EM seth.schwartz@vmmc.org OI Hapner, Edie/0000-0001-9666-911X FU American Academy of Otolaryngology-Head and Neck Surgery FX Sponsor and funding source: American Academy of Otolaryngology-Head and Neck Surgery. The cost of developing this guideline, including travel expenses of all panel members, was covered in full by the AAO-HNS Foundation. Members of the AAO-HNS and other allied health/physician organizations were involved with the study design and conduct; collection, analysis, and interpretation of the dam and writing or approval of the manuscript. NR 339 TC 108 Z9 120 U1 3 U2 29 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD SEP PY 2009 VL 141 IS 3 SU 2 BP S1 EP S31 DI 10.1016/j.otohns.2009.06.744 PG 31 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 491UH UT WOS:000269604700001 PM 19729111 ER PT J AU Buckenmaier, CC Croll, SM Shields, CH Shockey, SM Bleckner, LL Malone, G Plunkett, A McKnight, GM Kwon, KH Joltes, R Stojadinovic, A AF Buckenmaier, Chester C., III Croll, Scott M. Shields, Cynthia H. Shockey, Sean M. Bleckner, Lisa L. Malone, Greg Plunkett, Anthony McKnight, Geselle M. Kwon, Kyung H. Joltes, Richard Stojadinovic, Alexander TI Advanced Regional Anesthesia Morbidity and Mortality Grading System: Regional Anesthesia Outcomes Reporting (ROAR) SO PAIN MEDICINE LA English DT Article DE Regional Anesthesia; Peripheral Nerve Block; Continuous Peripheral Nerve Block; Outcomes; Morbidity ID PERIPHERAL-NERVE BLOCKADE; NEUROLOGICAL COMPLICATIONS; SURGERY; QUALITY AB Objective. A regional anesthesia complication grading system (regional anesthesia outcomes reporting [ROAR]) was developed and applied to 1,213 consecutive patients over a 14-month period. The goal of the project was the creation of a system to standardize complication reporting in the regional anesthesia literature. Design. Patient demographics, status as a war casualty, regional block procedure-specific details, and complication grade were entered into an Internet-based, encrypted Department of Defense database. Regional anesthesia complications were later graded and subcategorized depending on what phase of the block the procedural adverse event took place. Results. One thousand ninety-eight (90.5%) patients had neither regional anesthesia associated technical difficulties or more severe complications. Of a total of 147 cases with adverse events among 115 patients (1.3 per patient), the majority (63.3%, 93/147) were low-grade complications resulting in no significant morbidity. The most common complications resulting in patient morbidity were failed block requiring catheter removal and/or supplemental block (35.4%, 17/48). High grade complications represented only 4.1% (6/147) of all peri-procedural morbidity. These complications included pneumothorax requiring tube thoracostomy, transient laryngeal nerve dysfunction, and cancellation of planned operation after peripheral nerve block or catheter placement. Conclusions. The value of the ROAR system is that it identifies important issues in risk management in regional anesthesia, thereby providing opportunities for further investigation and clinical practice refinement. Furthermore, it provides for a common language when reporting outcomes in the regional anesthesia literature. Use of the ROAR system will provide consistency in outcomes reporting and facilitate comparisons between methods and procedures. C1 [Buckenmaier, Chester C., III; Croll, Scott M.; Shields, Cynthia H.; Shockey, Sean M.; Bleckner, Lisa L.; Malone, Greg; Plunkett, Anthony; McKnight, Geselle M.; Kwon, Kyung H.; Joltes, Richard; Stojadinovic, Alexander] Walter Reed Army Med Ctr, Army Reg Anesthesia & Pain Management Initiat, Anesthesia & Operat Serv, Washington, DC 20307 USA. [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. RP Buckenmaier, CC (reprint author), Walter Reed Army Med Ctr, Army Reg Anesthesia & Pain Management Initiat, Anesthesia & Operat Serv, Bldg 2,Ward 44,Room 4418,6900 Georgia Ave NW, Washington, DC 20307 USA. EM chester.buckenmaier@amedd.army.mil OI Buckenmaier III, Chester/0000-0003-3623-5525 FU John P. Murtha Neuroscience and Pain Institute, and departmental FX Financial support from John P. Murtha Neuroscience and Pain Institute, and departmental. NR 8 TC 4 Z9 4 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1526-2375 J9 PAIN MED JI Pain Med. PD SEP PY 2009 VL 10 IS 6 BP 1115 EP 1122 DI 10.1111/j.1526-4637.2009.00691.x PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 495PU UT WOS:000269906800017 PM 19744211 ER PT J AU Stojadinovic, A Shockey, SM Croll, SM Buckenmaier, CC AF Stojadinovic, Alexander Shockey, Sean M. Croll, Scott M. Buckenmaier, Chester C., III TI Quality of Reporting of Regional Anesthesia Outcomes in the Literature SO PAIN MEDICINE LA English DT Review DE Regional Anesthesia; Peripheral Nerve Block; Continuous Peripheral Nerve Block; Outcomes; Morbidity ID TOTAL KNEE ARTHROPLASTY; SCIATIC-NERVE BLOCK; BRACHIAL-PLEXUS BLOCK; PSOAS COMPARTMENT BLOCK; TOTAL HIP-ARTHROPLASTY; CONTROLLED INTERSCALENE ANALGESIA; CONTINUOUS FEMORAL BLOCK; OPEN SHOULDER SURGERY; CRUCIATE LIGAMENT RECONSTRUCTION; PATIENT-CONTROLLED TECHNIQUES AB Objective. Consistent and reliable standards for reporting of regional anesthetic adverse events are lacking. The quality of reporting of regional anesthetic morbidity has not been assessed critically. Aim. To evaluate quality of regional anesthesia outcomes reporting. Methods. Published retrospective or prospective observational cohort or randomized controlled trials in peer-reviewed journals were reviewed, and judged according to seven criteria related to quality of reporting of regional anesthesia complications: method of accrual, duration of data collection, definition of complication, morbidity and mortality rates, grade of complication severity, exclusion criteria, and study follow up. Differences in reporting outcomes according to study design, sample size and time period were compared. Results. Ninety-one articles published from 1996-2006 involving 8,833 patients were analyzed. The majority of studies (75%) met < 4 reporting criteria. Recently published, prospective studies with > 200 patients were associated with significantly higher-quality reporting (P < 0.05). Fewer than 50% of studies reported at least one recognized, accepted complication with defined criteria or indicated duration of follow up. Reporting compliance was worse (29%) for reporting of actual morbidity rates, and complications leading to death. Complication severity grading related to regional anesthesia was reported in 2% of studies. Conclusion. Consistent and comparative regional anesthesia outcome data are lacking in peer-reviewed journals. A graded regional anesthetic morbidity and mortality system according to the intensity of therapy required for the treatment of the defined complication is proposed, along with a structured format for the reporting of regional anesthesia complications according to defined reporting standards. C1 [Stojadinovic, Alexander; Shockey, Sean M.; Croll, Scott M.; Buckenmaier, Chester C., III] Walter Reed Army Med Ctr, Army Reg Anesthesia & Pain Management Initiat, Anesthesia & Operat Serv, Washington, DC 20307 USA. [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. RP Buckenmaier, CC (reprint author), Walter Reed Army Med Ctr, Army Reg Anesthesia & Pain Management Initiat, Anesthesia & Operat Serv, Bldg 2,Ward 44,Room 4418,6900 Georgia Ave NW, Washington, DC 20307 USA. EM chester.buckenmaier@amedd.army.mil OI Buckenmaier III, Chester/0000-0003-3623-5525 NR 92 TC 4 Z9 4 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1526-2375 EI 1526-4637 J9 PAIN MED JI Pain Med. PD SEP PY 2009 VL 10 IS 6 BP 1123 EP 1131 DI 10.1111/j.1526-4637.2009.00683.x PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA 495PU UT WOS:000269906800018 PM 19671083 ER PT J AU Everett, A Mclean, B Plunkett, A Buckenmaier, C AF Everett, Adam Mclean, Brian Plunkett, Anthony Buckenmaier, Chester TI A Unique Presentation of Complex Regional Pain Syndrome Type I Treated with a Continuous Sciatic Peripheral Nerve Block and Parenteral Ketamine Infusion: A Case Report SO PAIN MEDICINE LA English DT Review DE Ketamine; Peripheral Nerve Block; Chronic Pain ID REFLEX SYMPATHETIC DYSTROPHY; PATIENT AB Objective. To successfully treat a patient with complex regional pain syndrome, refractory to standard therapy, to enable a rapid and full return to professional duties. Setting. This case report describes the rapid resolution of an unusual presentation of complex regional pain syndrome type I after four days of treatment with a continuous sciatic peripheral nerve block and a concomitant parenteral ketamine infusion. The patient was initially diagnosed with complex regional pain syndrome (CRPS) I of the right lower extremity following an ankle inversion injury. Oral medication with naproxen and gabapentin, as well as desensitization therapy, failed to provide any relief of her symptoms. She was referred to the interventional pain management clinic. A lumbar sympathetic block failed to provide any relief. The patient was diagnosed with CRPS I and was admitted for treatment with a continuous peripheral nerve block and parenteral ketamine. Conclusion. This case suggests therapeutic benefit from aggressive treatment of both the peripheral and central components of CRPS. C1 [Plunkett, Anthony] Walter Reed Army Med Ctr, Anesthesia & Operat Serv, Washington, DC 20307 USA. RP Plunkett, A (reprint author), Walter Reed Army Med Ctr, Anesthesia & Operat Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM anthonyplunkett@comcast.net NR 18 TC 7 Z9 8 U1 0 U2 2 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1526-2375 J9 PAIN MED JI Pain Med. PD SEP PY 2009 VL 10 IS 6 BP 1136 EP 1139 DI 10.1111/j.1526-4637.2009.00684.x PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 495PU UT WOS:000269906800020 PM 19744217 ER PT J AU Takeo, S Hisamori, D Matsuda, S Vinetz, J Sattabongkot, J Tsuboi, T AF Takeo, Satoru Hisamori, Daisuke Matsuda, Shusaku Vinetz, Joseph Sattabongkot, Jetsumon Tsuboi, Takafumi TI Enzymatic characterization of the Plasmodium vivax chitinase, a potential malaria transmission-blocking target SO PARASITOLOGY INTERNATIONAL LA English DT Article DE Chitinase; Transmission-blocking; Plasmodium vivax; Allosamidin ID PROTEIN-SYNTHESIS SYSTEM; PARASITE CHITINASE; MOSQUITO MIDGUT; FALCIPARUM CHITINASE; VACCINE CANDIDATES; GALLINACEUM; ANTIBODY; INVASION; ENZYMES; PFCHT1 AB The chitinase (EC 3.2.1.14) of the human malaria parasite Plasmodium falciparum, PfCHT1, has been validated as a malaria transmission-blocking vaccine (TBV). The present study aimed to delineate functional characteristics of the P. vivax chitinase PvCHT1, whose primary structure differs from that of PfCHT1 by having proenzyme and chitin-binding domains. The recombinant protein rPvCHT1 expressed with a wheat germ cell-free system hydrolyzed 4-methylumbelliferone (4MU) derivatives of chitin oligosaccharides (beta-1,4-poly-N-acetyl glucosamine (GlcNAc)). An anti-rPvCHT1 polyclonal antiserum reacted with in vitro obtained P. vivax ookinetes in anterior cytoplasm, showing uneven patchy distribution. Enzymatic activity of rPvCHT1 shared the exclusive endochitinase property with parallelly expressed rPfCHT1 as demonstrated by a marked substrate preference for 4MU-GlcNAc(3) compared to shorter GlcNAc substrates. While rPvCHT1 was found to be sensitive to the general family-18 chitinase inhibitor, allosamidin, its pH (maximal in neutral environment) and temperature (max. at similar to 25 degrees C) activity profiles and sensitivity to allosamidin (IC(50) = 6 mu M) were different from rPfCHT1. The results in this first report of functional rPvCHT1 synthesis indicate that the P. vivax chitinase is enzymatically close to long form Plasmodium chitinases represented by P. gallinaceum PgCHT1. (C) 2009 Elsevier Ireland Ltd. All rights reserved. C1 [Takeo, Satoru; Hisamori, Daisuke; Matsuda, Shusaku; Tsuboi, Takafumi] Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime 7908577, Japan. [Vinetz, Joseph] Univ Calif San Diego, Sch Med, Div Infect Dis, Palade Labs 0741, La Jolla, CA 92093 USA. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Tsuboi, Takafumi] Ehime Univ, Venture Business Lab, Matsuyama, Ehime 7908577, Japan. RP Tsuboi, T (reprint author), Ehime Univ, Cell Free Sci & Technol Res Ctr, 3 Bunkyo Cho, Matsuyama, Ehime 7908577, Japan. EM tsuboi@ccr.ehime-u.ac.jp OI Vinetz, Joseph/0000-0001-8344-2004 FU Ministry of Education, Culture, Sports, Science and Technology of Japan [17790277, 18390129, 19406009, 19041053]; U.S. National Institutes of Health FX The authors are grateful for vivax malaria patients at Mae Sod district, Tak Province, Thailand for providing blood specimens, as well as the staff of the Vector Borne Disease Training Center, Pra Budhabat, Saraburi, Thailand, for assistance in setting up the field sites and the staff of the Department of Entomology, AFRIMS, Bangkok, Thailand. A chitinase specific inhibitor allosamidin is a kind gift from Dr. Shohei Sakuda, University of Tokyo, Japan. This work was supported in part by Grants-in-Aid for Scientific Research (17790277, 18390129 and 19406009) and Scientific Research on Priority Areas (19041053) from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and grants from the U.S. National Institutes of Health (JMV). NR 24 TC 15 Z9 16 U1 0 U2 1 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 1383-5769 J9 PARASITOL INT JI Parasitol. Int. PD SEP PY 2009 VL 58 IS 3 BP 243 EP 248 DI 10.1016/j.parint.2009.05.002 PG 6 WC Parasitology SC Parasitology GA 482VO UT WOS:000268917800008 PM 19427918 ER PT J AU Maranich, AM Rajnik, M AF Maranich, Ashley M. Rajnik, Michael TI Varicella-Specific Immunoglobulin G Titers in Commercial Intravenous Immunoglobulin Preparations SO PEDIATRICS LA English DT Article DE varicella zoster virus; intravenous immunoglobulin; vaccination ID ZOSTER IMMUNE GLOBULIN; PREVENTION AB BACKGROUND AND OBJECTIVES: Since the introduction of an effective vaccine in 1995, the incidence of primary varicella zoster virus (VZV) has greatly decreased. However, newborns and immunocompromised patients remain at risk for serious disease. Currently, varicella-specific immunoglobulin is recommended for treatment of nonimmune, exposed, high-risk patients with varicella-specific immunoglobulin. However, product inavailability has led to substitution of intravenous immunoglobulin (IVIg) for such prophylaxis on the basis of studies from the preimmunization era. No studies in the post-vaccine era have shown that IVIg contains adequate varicella-specific antibodies to protect patients at high risk. The overall effect of vaccination on varicella-specific immunoglobulin G (IgG) levels in donor-pooled IVIg products is unknown. We compared the varicella-specific IgG levels in prevaccine and current IVIg products. METHODS: We used stored historic IVIg samples and current samples from our inpatient pharmacy. All samples were tested for varicella-specific IgG levels by enzyme-linked immunosorbent assay. RESULTS: Ten historic lots and 24 current lots were tested. The overall mean value of varicella-specific IgG in the historic lots was 3.07 (SD: 0.70); the current lots had a mean of 3.83 (SD: 0.58). The postvaccine IVIg contained higher levels of antibody than the prevaccine lots. CONCLUSIONS: We found that current IVIg preparations continue to have high levels of varicella-specific IgG despite the changing epidemiology of how immunity has been obtained. Given the results of this study, it is reasonable for physicians to comfortably substitute IVIg for varicella-specific immunoglobulin preparations when treating high-risk patients exposed to VZV. Pediatrics 2009; 124: e484-e488 C1 [Maranich, Ashley M.] Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. [Maranich, Ashley M.; Rajnik, Michael] Uniformed Serv Univ Hlth Sci, Dept Pediat, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. RP Maranich, AM (reprint author), Walter Reed Army Med Ctr, Dept Pediat, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM amaranich@usuhs.mil NR 9 TC 5 Z9 5 U1 0 U2 2 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD SEP PY 2009 VL 124 IS 3 BP E484 EP E488 DI 10.1542/peds.2009-0047 PG 5 WC Pediatrics SC Pediatrics GA 488XH UT WOS:000269383100038 PM 19706589 ER PT J AU Van Iddekinge, CH Ferris, GR Heffner, TS AF Van Iddekinge, Chad H. Ferris, Gerald R. Heffner, Tonia S. TI TEST OF A MULTISTAGE MODEL OF DISTAL AND PROXIMAL ANTECEDENTS OF LEADER PERFORMANCE SO PERSONNEL PSYCHOLOGY LA English DT Article ID RANGE RESTRICTION; INDIVIDUAL-DIFFERENCES; JOB-PERFORMANCE; SELECTION PROCEDURES; COGNITIVE-ABILITY; SELF-EFFICACY; PERSONALITY; MOTIVATION; METAANALYSIS; EXPERIENCE AB The authors developed and tested a multistage model of distal and proximal predictors of leader performance in an effort to shed greater light on the intermediate linkages between broad leader traits and performance. Predictor and criterion data were obtained from 471 noncommissioned officers in the U.S. Army. A model with cognitive ability and 3 of the Big 5 personality factors as distal antecedents, leadership experiences and motivation to lead as semidistal antecedents, and the knowledge, skills, and ability (KSAs) to lead as proximal antecedents of leader performance provided a good fit to the data. More specifically, the effects of the distal and semidistal antecedents on leader performance were partially mediated by more proximal variables, whereas leader KSAs demonstrated a relatively strong, direct influence on performance. The 1 exception was that Conscientiousness-a hypothesized distal antecedent-had a notable direct effect on leader performance. The implications of these findings for leadership research and practice are discussed. C1 [Van Iddekinge, Chad H.; Ferris, Gerald R.] Florida State Univ, Coll Business, Dept Management, Tallahassee, FL 32306 USA. [Heffner, Tonia S.] USA, Res Inst Behav & Social Sci, Washington, DC USA. RP Van Iddekinge, CH (reprint author), Florida State Univ, Coll Business, Dept Management, 821 Acad Way,POB 3061110, Tallahassee, FL 32306 USA. EM cvanidde@fsu.edu NR 71 TC 29 Z9 29 U1 4 U2 30 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0031-5826 J9 PERS PSYCHOL JI Pers. Psychol. PD FAL PY 2009 VL 62 IS 3 BP 463 EP 495 PG 33 WC Psychology, Applied; Management SC Psychology; Business & Economics GA 483MS UT WOS:000268971500001 ER PT J AU Moghadam, A AF Moghadam, Assaf TI Unmodern Men in the Modern World: Radical Islam, Terrorism, and the War on Modernity SO PERSPECTIVES ON POLITICS LA English DT Book Review C1 [Moghadam, Assaf] US Mil Acad, West Point, NY 10996 USA. RP Moghadam, A (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1537-5927 J9 PERSPECT POLIT JI Perspect. Polit. PD SEP PY 2009 VL 7 IS 3 BP 701 EP 702 DI 10.1017/S1537592709990727 PG 3 WC Political Science SC Government & Law GA 584CN UT WOS:000276727700076 ER PT J AU Coohill, TP Sagripanti, JL AF Coohill, Thomas P. Sagripanti, Jose-Luis TI Bacterial Inactivation by Solar Ultraviolet Radiation Compared with Sensitivity to 254 nm Radiation SO PHOTOCHEMISTRY AND PHOTOBIOLOGY LA English DT Review ID BACILLUS-SUBTILIS SPORES; ENVIRONMENTAL UV-RADIATION; INDUCED DNA-DAMAGE; ESCHERICHIA-COLI; ACTION SPECTRA; DRINKING-WATER; B RADIATION; SALMONELLA-TYPHIMURIUM; ATMOSPHERIC-PRESSURE; PHOTOPRODUCT LYASE AB Our goal was to derive a quantitative factor that would allow us to predict the solar sensitivity of vegetative bacterial cells to natural solar radiation from the wealth of data collected for cells exposed to UVC (254 nm) radiation. We constructed a solar effectiveness spectrum for inactivation of vegetative bacterial cells by combining the available action spectra for vegetative cell killing in the solar range with the natural sunlight spectrum that reaches the ground. We then analyzed previous studies reporting the effects of solar radiation on vegetative bacterial cells and on bacterial spores. Although UVC-sensitive cells were also more sensitive to solar radiation, we found no absolute numerical correlation between the relative solar sensitivity of vegetative cells and their sensitivity to 254 nm radiation. The sensitivity of bacterial spores to solar exposure during both summer and winter correlated closely to their UVC sensitivity. The estimates presented here should make it possible to reasonably predict the time it would take for natural solar UV to kill bacterial spores or with a lesser degree of accuracy, vegetative bacterial cells after dispersion from an infected host or after an accidental or intentional release. C1 [Sagripanti, Jose-Luis] USA, Res & Technol Directorate, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. [Coohill, Thomas P.] Siena Coll, Dept Phys, Loudonville, NY USA. RP Sagripanti, JL (reprint author), USA, Res & Technol Directorate, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. EM joseluis.sagripanti@us.army.mil FU US Department of Defense Chemical and Biological Defense FX This work was supported by the US Department of Defense Chemical and Biological Defense program administered by the Defense Threat Reduction Agency. We thank Marc Ferrante and Stephanie Fazio for calculating UVB exposures. NR 121 TC 18 Z9 18 U1 0 U2 8 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0031-8655 J9 PHOTOCHEM PHOTOBIOL JI Photochem. Photobiol. PD SEP-OCT PY 2009 VL 85 IS 5 BP 1043 EP 1052 DI 10.1111/j.1751-1097.2009.00586.x PG 10 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 489YT UT WOS:000269463700001 PM 19659922 ER PT J AU Dongare, AM Rajendran, AM LaMattina, B Zikry, MA Brenner, DW AF Dongare, Avinash M. Rajendran, Arunachalam M. LaMattina, Bruce Zikry, Mohammed A. Brenner, Donald W. TI Atomic scale simulations of ductile failure micromechanisms in nanocrystalline Cu at high strain rates SO PHYSICAL REVIEW B LA English DT Article ID VOID GROWTH; MECHANICAL-BEHAVIOR; MOLECULAR-DYNAMICS; SPALL STRENGTH; FCC METALS; FRACTURE; COPPER; NUCLEATION; SOLIDS; MODEL AB The micromechanisms related to ductile failure during dynamic loading of nanocrystalline Cu are investigated in a series of large-scale molecular-dynamics (MD) simulations. Void nucleation, growth, and coalescence are studied for a nanocrystalline Cu system with an average grain size of 6 nm under conditions of uniaxial tensile strain and triaxial tensile strain at a strain rate of 10(8) s(-1). The MD simulations of deformation of the nanocrystalline system under conditions of triaxial tensile stress show random nucleation of voids at grain boundaries and/or triple point junctions. The initial shape of the voids is nonspherical due to growth of the voids along the grain boundaries. Void growth is observed to occur by the creation of a shell of disordered atoms around the voids and not by nucleation of dislocations from the void surface. Void coalescence occurs by the shearing of the disordered regions in between the voids. The nucleation and growth of voids result in the relaxation of tensile stresses, after which growth of the voids is slower. The slower growth is accompanied by recrystallization of the surrounding disordered regions resulting in near-spherical shapes of the voids. C1 [Dongare, Avinash M.; Brenner, Donald W.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Dongare, Avinash M.; Zikry, Mohammed A.] N Carolina State Univ, Dept Mech & Aerosp Engn, Raleigh, NC 27695 USA. [Rajendran, Arunachalam M.] Univ Mississippi, Dept Mech Engn, University, MS 38677 USA. [LaMattina, Bruce] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Dongare, AM (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Engn Bldg I,911 Partners Way,Campus Box 7907, Raleigh, NC 27695 USA. RI Brenner, Donald/D-1741-2009; Rajendran, Arunachalam/A-1615-2010; Dongare, Avinash/A-3470-2009; OI Dongare, Avinash/0000-0003-3189-3588 FU U. S. Army Research Office (ARO) through the National Research Council Research Associateship Program; National Science Foundation [DMR-0304299, DMR-0806323] FX A. M. D. is supported by the U. S. Army Research Office (ARO) through the National Research Council Research Associateship Program. D. W. B. and M.A.Z. are also supported by the National Science Foundation through Grants No. DMR-0304299 and No. DMR-0806323. NR 54 TC 34 Z9 36 U1 1 U2 26 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD SEP PY 2009 VL 80 IS 10 AR 104108 DI 10.1103/PhysRevB.80.104108 PG 11 WC Physics, Condensed Matter SC Physics GA 501LJ UT WOS:000270383100026 ER PT J AU Dumanian, GA Ko, JH O'Shaughnessy, KD Kim, PS Wilson, CJ Kuiken, TA AF Dumanian, Gregory A. Ko, Jason H. O'Shaughnessy, Kristina D. Kim, Peter S. Wilson, Christopher J. Kuiken, Todd A. TI Targeted Reinnervation for Transhumeral Amputees: Current Surgical Technique and Update on Results SO PLASTIC AND RECONSTRUCTIVE SURGERY LA English DT Article ID MYOELECTRIC PROSTHESIS CONTROL; NERVE TRANSFER; LONG HEAD; MUSCLE; TRICEPS AB Background: Targeted reinnervation in upper extremity transhumeral amputees can improve control and dexterity of myoelectric prostheses. The operation as described previously required a long residual limb and the presence of a brachialis muscle. Methods: Brachial plexus dissections were performed to confirm and better understand the branching pattern of the radial nerve in the upper arm. A simplified surgical approach for targeted reinnervation in transhumeral amputees was devised. This study reports on the first six transhumeral amputees who have undergone this simplified procedure. Results: The long and lateral heads of the triceps receive distinct and separate motor nerves from the proximal radial nerve. This anatomy allows a nerve transfer of the distal radial nerve to the motor nerve of the lateral head of the triceps without injury to the innervation of the long head of the triceps. The median nerve transfer to the motor branch of the medial head of the biceps is performed on the anterior surface of the arm as described previously. All six patients had successful targeted reinnervation procedures using this simplified approach. Conclusion: Targeted reinnervation for transhumeral amputees can now be performed in patients with amputations at the level of the middle of the humerus or longer. (Plast. Reconstr. Surg. 124: 863, 2009.) C1 [Dumanian, Gregory A.] Northwestern Univ, Feinberg Sch Med, Div Plast Surg, Dept Surg, Chicago, IL 60610 USA. Northwestern Univ, Feinberg Sch Med, Dept Phys Med & Rehabil, Chicago, IL 60610 USA. Rehabil Inst Chicago, Neural Engn Ctr Artificial Limbs, Detroit, MI USA. Brooke Army Med Ctr, Dept Orthoped, Ft Sam Houston, TX 78234 USA. RP Dumanian, GA (reprint author), Northwestern Univ, Feinberg Sch Med, Div Plast Surg, Dept Surg, 675 N St Clair,Suite 19-250, Chicago, IL 60610 USA. EM gdumania@nmh.org NR 9 TC 29 Z9 29 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0032-1052 J9 PLAST RECONSTR SURG JI Plast. Reconstr. Surg. PD SEP PY 2009 VL 124 IS 3 BP 863 EP 869 DI 10.1097/PRS.0b013e3181b038c9 PG 7 WC Surgery SC Surgery GA 490FT UT WOS:000269485200020 PM 19730305 ER PT J AU Yu, XP Ivanic, J Wallqvist, A Reifman, J AF Yu, Xueping Ivanic, Joseph Wallqvist, Anders Reifman, Jaques TI A Novel Scoring Approach for Protein Co-Purification Data Reveals High Interaction Specificity SO PLOS COMPUTATIONAL BIOLOGY LA English DT Article ID SACCHAROMYCES-CEREVISIAE; NETWORK; YEAST; COMPLEXES; MAP; ORGANIZATION; EXPRESSION AB Large-scale protein interaction networks (PINs) have typically been discerned using affinity purification followed by mass spectrometry (AP/MS) and yeast two-hybrid (Y2H) techniques. It is generally recognized that Y2H screens detect direct binary interactions while the AP/MS method captures co-complex associations; however, the latter technique is known to yield prevalent false positives arising from a number of effects, including abundance. We describe a novel approach to compute the propensity for two proteins to co-purify in an AP/MS data set, thereby allowing us to assess the detected level of interaction specificity by analyzing the corresponding distribution of interaction scores. We find that two recent AP/MS data sets of yeast contain enrichments of specific, or high-scoring, associations as compared to commensurate random profiles, and that curated, direct physical interactions in two prominent data bases have consistently high scores. Our scored interaction data sets are generally more comprehensive than those of previous studies when compared against four diverse, high-quality reference sets. Furthermore, we find that our scored data sets are more enriched with curated, direct physical associations than Y2H sets. A high-confidence protein interaction network (PIN) derived from the AP/MS data is revealed to be highly modular, and we show that this topology is not the result of misrepresenting indirect associations as direct interactions. In fact, we propose that the modularity in Y2H data sets may be underrepresented, as they contain indirect associations that are significantly enriched with false negatives. The AP/MS PIN is also found to contain significant assortative mixing; however, in line with a previous study we confirm that Y2H interaction data show weak disassortativeness, thus revealing more clearly the distinctive natures of the interaction detection methods. We expect that our scored yeast data sets are ideal for further biological discovery and that our scoring system will prove useful for other AP/MS data sets. C1 [Yu, Xueping; Ivanic, Joseph; Wallqvist, Anders; Reifman, Jaques] USA, Biotechnol HPC Software Applicat Inst, Telemedicine & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD USA. RP Yu, XP (reprint author), USA, Biotechnol HPC Software Applicat Inst, Telemedicine & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD USA. EM jaques.reifman@us.army.mil OI wallqvist, anders/0000-0002-9775-7469 FU U. S. Army Medical Research and Materiel Command; U. S. Army's Network Science Initiative FX The authors were supported, in part, by the Military Operational Medicine research program of the U. S. Army Medical Research and Materiel Command, Ft. Detrick, Maryland. This effort was supported by the U. S. Army's Network Science Initiative. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 34 TC 20 Z9 20 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1553-734X J9 PLOS COMPUT BIOL JI PLoS Comput. Biol. PD SEP PY 2009 VL 5 IS 9 AR e1000515 DI 10.1371/journal.pcbi.1000515 PG 14 WC Biochemical Research Methods; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Mathematical & Computational Biology GA 506TV UT WOS:000270800100005 PM 19779545 ER PT J AU Cummings, DAT Iamsirithaworn, S Lessler, JT McDermott, A Prasanthong, R Nisalak, A Jarman, RG Burke, DS Gibbons, RV AF Cummings, Derek A. T. Iamsirithaworn, Sopon Lessler, Justin T. McDermott, Aidan Prasanthong, Rungnapa Nisalak, Ananda Jarman, Richard G. Burke, Donald S. Gibbons, Robert V. TI The Impact of the Demographic Transition on Dengue in Thailand: Insights from a Statistical Analysis and Mathematical Modeling SO PLOS MEDICINE LA English DT Article ID HEMORRHAGIC-FEVER; TRANSMISSION DYNAMICS; DEPENDENT ENHANCEMENT; INFECTIOUS-DISEASES; RISK-FACTORS; CHILDREN; EPIDEMIOLOGY; CIRCULATION; PATTERNS; BANGKOK AB Background: An increase in the average age of dengue hemorrhagic fever (DHF) cases has been reported in Thailand. The cause of this increase is not known. Possible explanations include a reduction in transmission due to declining mosquito populations, declining contact between human and mosquito, and changes in reporting. We propose that a demographic shift toward lower birth and death rates has reduced dengue transmission and lengthened the interval between large epidemics. Methods and Findings: Using data from each of the 72 provinces of Thailand, we looked for associations between force of infection (a measure of hazard, defined as the rate per capita at which susceptible individuals become infected) and demographic and climactic variables. We estimated the force of infection from the age distribution of cases from 1985 to 2005. We find that the force of infection has declined by 2% each year since a peak in the late 1970s and early 1980s. Contrary to recent findings suggesting that the incidence of DHF has increased in Thailand, we find a small but statistically significant decline in DHF incidence since 1985 in a majority of provinces. The strongest predictor of the change in force of infection and the mean force of infection is the median age of the population. Using mathematical simulations of dengue transmission we show that a reduced birth rate and a shift in the population's age structure can explain the shift in the age distribution of cases, reduction of the force of infection, and increase in the periodicity of multiannual oscillations of DHF incidence in the absence of other changes. Conclusions: Lower birth and death rates decrease the flow of susceptible individuals into the population and increase the longevity of immune individuals. The increase in the proportion of the population that is immune increases the likelihood that an infectious mosquito will feed on an immune individual, reducing the force of infection. Though the force of infection has decreased by half, we find that the critical vaccination fraction has not changed significantly, declining from an average of 85% to 80%. Clinical guidelines should consider the impact of continued increases in the age of dengue cases in Thailand. Countries in the region lagging behind Thailand in the demographic transition may experience the same increase as their population ages. The impact of demographic changes on the force of infection has been hypothesized for other diseases, but, to our knowledge, this is the first observation of this phenomenon. C1 [Cummings, Derek A. T.; Lessler, Justin T.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. [Iamsirithaworn, Sopon; Prasanthong, Rungnapa] Minist Publ Hlth, Bur Epidemiol, Nonthaburi, Thailand. [McDermott, Aidan] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Biostat, Baltimore, MD USA. [Nisalak, Ananda; Jarman, Richard G.; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Burke, Donald S.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA. RP Cummings, DAT (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. EM dcumming@jhsph.edu OI Lessler, Justin/0000-0002-9741-8109; /0000-0002-5704-8094 FU National Institute of General Medical Sciences MIDAS [U01-GM070749]; Gates Foundation; Burroughs Wellcome Fund FX This work was supported by the National Institute of General Medical Sciences MIDAS (Grant U01-GM070749) and the Gates Foundation. DATC holds a Career Award at the Scientific Interface from the Burroughs Wellcome Fund. The study sponsors had no role in the study design; collection, analysis, and interpretation of data; writing of the paper; and decision to submit it for publication. NR 36 TC 82 Z9 84 U1 4 U2 25 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1549-1277 J9 PLOS MED JI PLos Med. PD SEP PY 2009 VL 6 IS 9 AR e1000139 DI 10.1371/journal.pmed.1000139 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA 506ZH UT WOS:000270818100007 PM 19721696 ER PT J AU Al-Smadl, YM Russell, K Sodhi, RS AF Al-Smadl, Y. M. Russell, K. Sodhi, R. S. TI Four-bar motion generation with elasticity constraints and optimization SO PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART K-JOURNAL OF MULTI-BODY DYNAMICS LA English DT Article DE motion generation; coupler force; elastic deflection; buckling; selection algorithm ID RIGID-BODY MOTION; MECHANISMS; LINKAGES; PLANAR AB In conventional planar four-bar motion generation, all mechanism links are assumed rigid or non-deforming. Although the assumption of link rigidity in kinematic synthesis may be generally appropriate and often practiced, a statically loaded planar four-bar mechanism will undergo a degree of elastic deflection, particularly the crank and follower links. In this work, a non-linear optimization problem is formulated for planar four-bar motion generation that considers an applied coupler force and corresponding crank static torque, crank transverse deflection, and follower buckling. The output from the non-linear optimization problem - mechanism fixed and moving pivot loci - are input for a search algorithm that down selects a mechanism solution that satisfies transmission angle conditions, Grashof conditions, and a mechanism compactness condition. The final output of the presented method is planar four-bar motion generator that approximates prescribed coupler poses with satisfactory crank deflection and without follower buckling and also satisfies conditions for link rotatability, transmission angle and compactness. C1 [Al-Smadl, Y. M.] AECOM, Special Struct Grp, New York, NY 10005 USA. [Russell, K.] USA, Armaments Engn & Technol Ctr, Ctr Res Dev & Engn, Picatinny Arsenal, NJ USA. [Sodhi, R. S.] New Jersey Inst Technol, Dept Mech Engn, Newark, NJ 07102 USA. RP Al-Smadl, YM (reprint author), AECOM, Special Struct Grp, New York, NY 10005 USA. EM yahia.al-smadi@aecom.com NR 20 TC 2 Z9 2 U1 1 U2 1 PU PROFESSIONAL ENGINEERING PUBLISHING LTD PI WESTMINISTER PA 1 BIRDCAGE WALK, WESTMINISTER SW1H 9JJ, ENGLAND SN 1464-4193 J9 P I MECH ENG K-J MUL JI Proc. Inst. Mech Eng Pt K-J Multi-Body Dyn. PD SEP PY 2009 VL 223 IS 3 BP 245 EP 253 DI 10.1243/14644193JMBD173 PG 9 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 501SP UT WOS:000270402800007 ER PT J AU Floyd, FL Avudaiappan, S Gibson, J Mehta, B Smith, P Provder, T Escarsega, J AF Floyd, F. Louis Avudaiappan, Sundaresan Gibson, Jason Mehta, Bhaumik Smith, Pauline Provder, Theodore Escarsega, John TI Using electrochemical impedance spectroscopy to predict the corrosion resistance of unexposed coated metal panels SO PROGRESS IN ORGANIC COATINGS LA English DT Review DE Corrosion; Electrochemical impedance spectroscopy; Salt fog testing; Pretreatment; Primer; Topcoat ID ORGANIC COATINGS; PERFORMANCE; STEEL; INHIBITORS; PHOSPHATE; ADHESION; EVALUATE; PRIMER; ZINC; EIS AB The goal of the current work was to determine if electrochemical impedance spectroscopy (EIS) testing of a series of coated but unexposed metal panels could predict the corrosion results of other sections of the same coated panels that were subjected to both continuous and cyclic corrosion testing. Variables included metal, pretreatment, primer, and topcoat. EIS results were shown to be strongly dependent upon the time-of-residence in the electrochemical cell prior to commencement of testing, and to the choice of electrolyte used in the cell. Good correlations between EIS and corrosion testing were seen for topcoat effects, but not for pretreatment effects. EIS results appear to relate mostly to barrier properties rather than electrochemical properties of coatings. It is suggested that the variation seen in EIS solution resistance values (R,) can be utilized to quantify total system error. Total error was estimated by three techniques: total Rs variation, panel replicate variation, and EIS reading replication. The three approaches yielded similar results: total error for equivalent circuit components expressed in log(10) form was on the order of 50%, expressed as percent standard deviation. (C) 2009 Elsevier B.V. All rights reserved. C1 [Provder, Theodore] Polymer & Coatings Consultants LLC, Solon, OH USA. [Avudaiappan, Sundaresan; Gibson, Jason; Mehta, Bhaumik] Eastern Michigan Univ, Ypsilanti, MI 48197 USA. [Smith, Pauline; Escarsega, John] USA, Res Lab, Aberdeen Proving Ground, MD USA. RP Provder, T (reprint author), Polymer & Coatings Consultants LLC, Solon, OH USA. EM tprovder@att.net FU U.S. Department of the Army, Tank-Automotive and Armaments Command JACOM [DDAE07-03-C-LI27]; Army Research Laboratory (ARL) [DAAD19-03-2-0013] FX Martin Donbroskyjr., Chemir Analytical Services, Ypsilanti, Mi., for technical discussions and support of some of the laboratory work. NR 37 TC 15 Z9 17 U1 3 U2 18 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0300-9440 J9 PROG ORG COAT JI Prog. Org. Coat. PD SEP PY 2009 VL 66 IS 1 BP 8 EP 34 DI 10.1016/j.porgcoat.2009.04.009 PG 27 WC Chemistry, Applied; Materials Science, Coatings & Films SC Chemistry; Materials Science GA 487SQ UT WOS:000269296400002 ER PT J AU Freed, MC Yeager, DE Liu, X Gore, KL Engel, CC Magruder, KM AF Freed, Michael C. Yeager, Derik E. Liu, Xian Gore, Kristie L. Engel, Charles C. Magruder, Kathryn M. TI Preference-Weighted Health Status of PTSD Among Veterans: An Outcome for Cost-Effectiveness Analysis Using Clinical Data SO PSYCHIATRIC SERVICES LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; PRIMARY-CARE; UTILITY MEASURES; METAANALYSIS; SYMPTOMS; PHARMACOTHERAPY; AFGHANISTAN; PREVALENCE; VALIDATION; CHECKLIST AB Objective: Posttraumatic stress disorder (PTSD) is a highly prevalent, chronic, disabling but treatable condition. Preference-based measures (for example, health utilities) are recommended for and useful in cost-effectiveness analyses and for policy decisions because they reflect a population's valuation of the desirability of disease states. However, no such measures exist for PTSD. This study aimed to estimate preference-weighted health status associated with PTSD and common co-occurring mental disorders in a sample of veterans by transforming health-related quality-of-life data into preference-weighted health status scores (PWHS scores), develop a usable regression model to predict PWHS scores from other data sets, and compare preference-weighted health status of PTSD with that of another chronic disorder, chronic obstructive pulmonary disease (COPD). Methods: A secondary analysis was performed on data from a random sample of 808 veterans (79% male; 12% met criteria for PTSD) in four primary care clinics. Veterans responded to the PTSD Checklist (PCL), Clinician-Administered PTSD Scale, Mini-International Neuropsychiatric Interview, and Medical Outcomes Survey Short Form-36. Results: PWHS scores were .029 lower among veterans with PTSD compared with veterans without PTSD, all else being equal. However, scores depended on PTSD severity, when the analysis controlled for other model variables. Specifically, PWHS scores dropped by .004 with a 1-unit increase in PCL scores among veterans without PTSD. Among veterans with PTSD, the reduction was .002. PTSD was associated with lower preference-weighted health status than COPD. Conclusions: This is the first study to estimate preference-weighted health status of persons with PTSD. These PWHS scores can be helpful in cost-effectiveness studies of PTSD treatments. (Psychiatric Services 60: 1230-1238, 2009) C1 [Freed, Michael C.; Liu, Xian; Gore, Kristie L.; Engel, Charles C.] Walter Reed Army Med Ctr, Deployment Hlth Clin Ctr, Washington, DC 20307 USA. [Freed, Michael C.; Liu, Xian; Gore, Kristie L.; Engel, Charles C.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA. [Yeager, Derik E.; Magruder, Kathryn M.] Med Univ S Carolina, Ralph H Johnson Vet Affairs Med Ctr, Charleston, SC 29425 USA. [Yeager, Derik E.; Magruder, Kathryn M.] Med Univ S Carolina, Dept Psychiat & Behav Sci, Charleston, SC 29425 USA. RP Freed, MC (reprint author), Walter Reed Army Med Ctr, Deployment Hlth Clin Ctr, Bldg 2,Room 3E01,6900 Georgia Ave,NW, Washington, DC 20307 USA. EM mc_freed@onebox.com FU Veterans Affairs Health Services Research and Development [VCR-99-010-2] FX This work was partly supported by grant VCR-99-010-2 (to Dr. Magruder) funded by the Veterans Affairs Health Services Research and Development program. The authors thank Phoebe Kuesters, B. A., and Leah Russell, M. A., for their administrative support. The views expressed in this manuscript are those of the authors and do not necessarily represent the official policy or position of the Deployment Health Clinical Center, Walter Reed Army Medical Center, Uniformed Services University of the Health Sciences, Department of Defense, Department of Veterans Affairs, United States Government, or Medical University of South Carolina. NR 45 TC 7 Z9 7 U1 1 U2 5 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 1075-2730 J9 PSYCHIAT SERV JI Psychiatr. Serv. PD SEP PY 2009 VL 60 IS 9 BP 1230 EP 1238 PG 9 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychiatry SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychiatry GA 489RD UT WOS:000269438700012 PM 19723738 ER PT J AU Snow, DJ AF Snow, Doris J. TI Psychodynamic Group Psychotherapy, 4th edition SO PSYCHIATRY-INTERPERSONAL AND BIOLOGICAL PROCESSES LA English DT Book Review C1 [Snow, Doris J.] Walter Reed Army Med Ctr, Dept Child Psychiat, Washington, DC 20307 USA. RP Snow, DJ (reprint author), Borden Bldg,2nd Floor,Georgia & Aspen Ave, Washington, DC 20307 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 72 SPRING STREET, NEW YORK, NY 10012 USA SN 0033-2747 J9 PSYCHIATRY JI Psychiatry-Interpers. Biol. Process. PD FAL PY 2009 VL 72 IS 3 BP 303 EP 305 PG 3 WC Psychiatry SC Psychiatry GA 500FX UT WOS:000270285200009 ER PT J AU Smith, R AF Smith, Roger TI COMPUTING IN THE CLOUD SO RESEARCH-TECHNOLOGY MANAGEMENT LA English DT Editorial Material C1 [Smith, Roger] US Army Simulat Training & Instrumentat, Orlando, FL USA. RP Smith, R (reprint author), US Army Simulat Training & Instrumentat, Orlando, FL USA. EM rdsmith@modelbenders.com NR 9 TC 8 Z9 8 U1 1 U2 4 PU INDUSTRIAL RESEARCH INST, INC PI ARLINGTON PA 2200 CLARENDON BLVD, STE 1102, ARLINGTON, VA 22201 USA SN 0895-6308 J9 RES TECHNOL MANAGE JI Res.-Technol. Manage. PD SEP-OCT PY 2009 VL 52 IS 5 BP 65 EP 68 PG 4 WC Business; Engineering, Industrial; Management SC Business & Economics; Engineering GA 489YX UT WOS:000269464100010 ER PT J AU Allan, PF Thomas, KV Ward, MR Harris, AD Naworol, GA Ward, JA AF Allan, Patrick F. Thomas, Kimbreca V. Ward, Michael R. Harris, Anthony D. Naworol, Gregory A. Ward, John A. TI Feasibility Study of Noninvasive Ventilation With Helium-Oxygen Gas Flow for Chronic Obstructive Pulmonary Disease During Exercise SO RESPIRATORY CARE LA English DT Article DE chronic obstructive pulmonary disease; helium; oxygen; noninvasive positive pressure ventilation; exercise capacity ID POSITIVE-PRESSURE VENTILATION; DYNAMIC HYPERINFLATION; SUPPLEMENTAL OXYGEN; LUNG HYPERINFLATION; SEVERE COPD; MECHANICS; DYSPNEA; SUPPORT; REHABILITATION; LIMITATION AB BACKGROUND: Individually, noninvasive ventilation (NIV) and helium-oxygen gas mixtures (heliox) diminish ventilatory workload and improve exercise tolerance in patients with chronic obstructive pulmonary disease (COPD). NIV in combination with heliox may have additive effects on exercise tolerance in severe COPD. METHODS: We assessed the safety, tolerability, and efficacy of heliox and NIV during exercise in patients with severe COPD. SETTING: Pulmonary rehabilitation facility in an academic tertiary-care medical center. PROTOCOL: Twelve patients with severe COPI) were enrolled. Using a sequential randomized placebo-controlled crossover study design, the patients performed 4 separate constant-work stationary bicycle cardiopulmonary exercise studies at 80% of maximal workload during application of sham NIV, NIV, 60:40 heliox with sham NIV, and 60:40 heliox with NIV. Tolerability, safety, and exercise duration as determined by constant-work cardiopulmonary exercise test were the primary outcome measures. Secondary outcome measures at peak exercise and iso-time included rate of perceived exertion, dyspnea, leg pain, heart rate, respiratory rate, systolic and diastolic blood pressure, tympanic temperature, and oxyhemoglobin saturation. RESULTS: No adverse effects occurred during or after application of NIV, heliox, or NIV with heliox. Exercise duration using heliox with NIV was significantly longer than both heliox (P = .01) and NIV (P = .007), but not placebo (P = .09). Relative to placebo, all treatment arms permitted lower respiratory rates at peak exercise. Heliox, with or without NIV, was associated with significant improvements in oxyhemoglobin saturation at peak exercise, relative to placebo or NIV alone. CONCLUSIONS: The adjunctive use of NIV with heliox during exercise proved both safe and tolerable in patients with severe COPD. The lack of demonstrable efficacy to any of the treatment arms relative to placebo (P = .09) may be the result of the small sample size (ie, type 2 error)-a conclusion emphasized by the large standard deviations and differences in treatment group variances in exercise duration alone. C1 [Thomas, Kimbreca V.; Ward, Michael R.; Harris, Anthony D.; Naworol, Gregory A.] Wilford Hall USAF Med Ctr, Dept Resp Therapy, Lackland AFB, TX USA. [Ward, John A.] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. RP Allan, PF (reprint author), Landstuhl Reg Med Ctr, Dept Pulm Crit Care & Sleep Med, CMR 402,Box 307, APO, AE 09180 USA. EM patrick.allan@amedd.army.mil NR 28 TC 9 Z9 10 U1 1 U2 1 PU DAEDALUS ENTERPRISES INC PI IRVING PA 9425 N MAC ARTHUR BLVD, STE 100, IRVING, TX 75063-4706 USA SN 0020-1324 J9 RESP CARE JI Respir. Care PD SEP PY 2009 VL 54 IS 9 BP 1175 EP 1182 PG 8 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 494JH UT WOS:000269808400005 PM 19712493 ER PT J AU Kim, JH Yang, JZ Abdel-Malek, K AF Kim, Joo H. Yang, Jingzhou Abdel-Malek, Karim TI Planning load-effective dynamic motions of highly articulated human model for generic tasks SO ROBOTICA LA English DT Article DE Motion planning; Equation of motion; Load-effective; Optimization; Redundant; General external load; Tree structure ID REDUNDANT MANIPULATORS; ROBOT MOTION; OPTIMIZATION; CONSTRAINTS; ALGORITHM; DECOMPOSITION; OBSTACLES AB The robotic motion planning criteria has evolved from kinematics to dynamics in recent years. Many research achievements have been made in dynamic motion planning, but the externally applied loads are usually limited to the gravity force. Due to the increasing demand for generic tasks, the motion should be generated for various functions such as pulling, pushing, twisting, and bending. In this paper, a comprehensive form of equations of motion, which includes the general external loads applied at any point of branched tree structures, is implemented. An optimization-based algorithm is then developed to generate load-effective motions of redundant tree-structured systems for generic tasks. A highly articulated dual-arm human model is used to generate different effective motions to sustain different external load magnitudes. The results also provide a new scientific insight of human motion. C1 [Kim, Joo H.; Abdel-Malek, Karim] Univ Iowa, USA, Virtual Soldier Res Program, Ctr Comp Aided Design, Iowa City, IA 52242 USA. [Yang, Jingzhou] Texas Tech Univ, Dept Mech Engn, Lubbock, TX 79409 USA. RP Kim, JH (reprint author), Univ Iowa, USA, Virtual Soldier Res Program, Ctr Comp Aided Design, Iowa City, IA 52242 USA. EM jookim@engineering.uiowa.edu RI Yang, James/G-9801-2012; Kim, Joo/I-9517-2012 FU U.S. Army Tank Automotive Research, Development and Engineering Center; U.S. Army Natick Soldier Systems Center FX This research is partially supported by the U.S. Army Tank Automotive Research, Development and Engineering Center and the U.S. Army Natick Soldier Systems Center. NR 46 TC 17 Z9 18 U1 1 U2 3 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0263-5747 J9 ROBOTICA JI Robotica PD SEP PY 2009 VL 27 BP 739 EP 747 DI 10.1017/S0263574708005110 PG 9 WC Robotics SC Robotics GA 492RD UT WOS:000269676000009 ER PT J AU Proctor, SP Heaton, KJ Dos Santos, KD Rosenman, ES Heeren, T AF Proctor, Susan P. Heaton, Kristin J. Dos Santos, Kathryn Dutille Rosenman, Erik S. Heeren, Timothy TI Prospective assessment of neuropsychological functioning and mood in US Army National Guard personnel deployed as peacekeepers SO SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH LA English DT Article DE deployment; military; neurobehavior; peacekeeping ID GULF-WAR VETERANS; JOB STRAIN; HEALTH; BOREDOM; FATIGUE; STRESS; ASSOCIATION; PERFORMANCE; POPULATION; PREVALENCE AB Objective The present study examined the impact of deployment on neuropsychological functioning and mood in Army National Guard personnel. We hypothesized that deployment on a peacekeeping mission, compared to non-deployment, would result in reduced proficiencies in neuropsychological performance and negative mood changes, and that such changes would relate to working in a high-strain job (high demands/low control), in accordance with Karasek's demand-control model. Methods This prospective cohort study involved 119 male soldiers (67 participants examined before and after deployment to the Bosnia operational theatre and 52 non-deployed soldiers assessed twice over a comparable period). Results Unit-level adjusted, multivariate analyses found that deployed soldiers, compared to their non-deployed counterparts, demonstrated reduced proficiency in tasks involving motor speed [unstandardized coefficient B= -3.88, 95% confidence interval (95% Cl) -6.38- -1.39; B= -3.84, 95% CI -5.55- -2.14; dominant and non-dominant hand, respectively] and sustained attention (B=0.031, 95% CI 0.009-0.054), along with decreased vigor (B= -2.71, 95% CI -3.63- -1.77). Deployed soldiers also showed improved proficiency in a working-memory task (B= -0.098, 95% CI -0.136- -0.060) with less depression symptomatology (B= -3.19, 95% CI -5.26- -1.13). Work stress levels increased over time in both deployed and non-deployed groups, but observed deployment effects remained significant after accounting for a high-strain job. Conclusion The observed change in performance associated with peacekeeping deployment compared to non-deployment (slowed processing speed, reduced motor speed and reported vigor, together with improved proficiency in a working memory task) suggests an adaptive response to mission occupational stressors. This pattern does not appear to be influenced by working in a high-strain job. Further study is required to examine whether these results reflect transient or permanent changes in functioning. C1 [Proctor, Susan P.; Heaton, Kristin J.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Proctor, Susan P.] Vet Affairs Boston Healthcare Syst, Res Serv, Boston, MA USA. [Proctor, Susan P.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. [Dos Santos, Kathryn Dutille] SE Ctr Healthy Communities, Brockton, MA USA. [Rosenman, Erik S.] Eidet Div Quintiles Consulting, Boston, MA USA. [Heeren, Timothy] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA. RP Proctor, SP (reprint author), USA, Environm Med Res Inst, Mil Performance Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM susan.proctor@us.army.mil RI Heaton, Kristin/E-3660-2013 NR 60 TC 4 Z9 4 U1 1 U2 5 PU SCANDINAVIAN JOURNAL WORK ENVIRONMENT & HEALTH PI HELSINKI PA TOPELIUKSENKATU 41A, SF-00250 HELSINKI, FINLAND SN 0355-3140 J9 SCAND J WORK ENV HEA JI Scand. J. Work Environ. Health PD SEP PY 2009 VL 35 IS 5 BP 349 EP 360 PG 12 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 493MA UT WOS:000269739700005 PM 19730757 ER PT J AU Hover, C Banasik, M Harbison, RD Price, DJ Hardy, M Stedeford, T AF Hover, Carl Banasik, Marek Harbison, Raymond D. Price, Debra J. Hardy, Marcia Stedeford, Todd TI Occurrence of five classes of chemicals in indoor dust: An evaluation of the human health risks SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Letter ID DEVELOPMENTAL NEUROTOXICITY; STATISTICAL ISSUES; MICE C1 [Hover, Carl] USA, Safety Environm & Integrated Planning Off, Ft Detrick, MD 21702 USA. [Banasik, Marek] Natl Inst Publ Hlth & Environm Protect, PL-02835 Warsaw, Poland. [Harbison, Raymond D.] Univ S Florida, Coll Publ Hlth, Ctr Environm & Occupat Risk Anal & Management, Tampa, FL 33612 USA. [Price, Debra J.] Environm Protect Commiss Hillsborough Cty, Air Management Div, Tampa, FL 33619 USA. [Hardy, Marcia; Stedeford, Todd] Hlth Safety & Environm Albemarle Corp, Baton Rouge, LA 70801 USA. RP Hover, C (reprint author), USA, Safety Environm & Integrated Planning Off, 810 Schreider St, Ft Detrick, MD 21702 USA. EM Carl.Hover@us.army.mil NR 11 TC 1 Z9 1 U1 1 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD SEP 1 PY 2009 VL 407 IS 18 BP 5194 EP 5196 DI 10.1016/j.scitotenv.2009.04.019 PG 3 WC Environmental Sciences SC Environmental Sciences & Ecology GA 486VJ UT WOS:000269228000027 PM 19419754 ER PT J AU Sawyer, T Hara, K Thompson, MW Chan, DS Berg, B AF Sawyer, Taylor Hara, Kris Thompson, Mark W. Chan, Debora S. Berg, Benjamin TI Modification of the Laerdal SimBaby to Include an Integrated Umbilical Cannulation Task Trainer SO SIMULATION IN HEALTHCARE LA English DT Article DE Neonatal resuscitation; Umbilical catheter; Umbilical cannulation; Neonatal simulator; SimBaby; SimNewB; Task trainer; Modification ID CARDIOPULMONARY-RESUSCITATION; DELIVERY ROOM; INTRAVENOUS EPINEPHRINE; ENDOTRACHEAL; DOGS AB Background: Given the emphasis on early vascular access via the umbilical vein in neonatal resuscitation it is essential that participants in neonatal resuscitation simulation training be given the opportunity to practice both the placement and use of an emergency umbilical venous catheter. By integrating available parts from the Laerdal catalog, combined with a few other inexpensive components, into a Laerdal SimBaby we were able to create a single, integrated neonatal simulator that could be used to practice both the placement and use of an emergent umbilical vein catheter. Methods: To integrate an umbilical cannulation task trainer into the Laerdal SimBaby we used a specially modified replaceable umbilical cord and reservoir from the Laerdal Neonatal Resuscitation Baby. To this reservoir we attached a flanged outlet drain and drainage tube which allows for the infusion of medications and fluids. The modified SimBaby with integrated umbilical cannulation task trainer was validated for both face and content by simulation participants and a panel of neonatal resuscitation experts. Results: The umbilical cannulation task trainer integrated well into the SimBaby and in no way altered the function of the mannequin. The modified Laerdal SimBaby was thought to work well by both participants and experts. Simulation participants liked having the chance to practice emergency umbilical vein cannulation and thought that the simulated umbilical cord was an important component in their learning experience. The expert panel thought that the modified SimBaby could be used for emergency umbilical vein cannulation skills training and that the addition gave the modified SimBaby major advantage over other simulators they had used to teach newborn resuscitation. Discussion: We have developed a modification to the Laerdal SimBaby involving the integration of a usable umbilical cannulation task trainer. The modification was easily accomplished using available parts from the Laerdal catalog and a few other inexpensive components. Given the emphasis on early vascular access via the umbilical vein and the complexities involved with the administration of medications and fluids via this route we believe that a usable umbilical cannulation task trainer is essential to neonatal resuscitation simulation training. When modified as described the Laerdal SimBaby can act as a high-fidelity newborn simulator that allows participants to practice both the placement and use of an emergency umbilical vessel catheter. Given our positive experience we think others could apply the above modification to their own SimBaby. (Sim Healthcare 4: 174-178, 2009) C1 [Sawyer, Taylor; Thompson, Mark W.; Chan, Debora S.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. [Hara, Kris; Berg, Benjamin] Univ Hawaii Manoa, Telehlth Res Inst, John A Burns Sch Med, Honolulu, HI 96822 USA. RP Sawyer, T (reprint author), Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. EM taylor.l.sawyer@us.army.mil NR 8 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-2332 J9 SIMUL HEALTHC JI Simul. Healthc. PD FAL PY 2009 VL 4 IS 3 BP 174 EP 178 DI 10.1097/SIH.0b013e31817bcaeb PG 5 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 588EL UT WOS:000277050300008 PM 19680085 ER PT J AU Wittstein, JR O'Brien, SD Vinson, EN Garrett, WE AF Wittstein, Jocelyn R. O'Brien, Seth D. Vinson, Emily N. Garrett, William E., Jr. TI MRI evaluation of anterior knee pain: predicting response to nonoperative treatment SO SKELETAL RADIOLOGY LA English DT Article DE Patellofemoral pain syndrome; Chondromalacia patellae; Magnetic resonance imaging ID TIBIAL TUBERCLE POSITION; PATELLOFEMORAL JOINT; CHONDROMALACIA PATELLAE; MALALIGNMENT; MALPOSITION; FLEXION; CT AB Tibial tubercle lateral deviation and patellofemoral chondromalacia are associated with anterior knee pain (AKP). We hypothesized that increased tibial tubercle lateral deviation and patellofemoral chondromalacia on magnetic resonance imaging correlates with the presence of AKP and with failure of nonoperative management. In this retrospective comparative study, a blinded musculoskeletal radiologist measured tibial tubercle lateral deviation relative to the trochlear groove in 15 controls, 15 physical therapy responders with AKP, and 15 physical therapy nonresponders with AKP. Patellar and trochlear cartilage was assessed for signal abnormality, irregularity, and defects. The mean tibial tubercle lateral deviation in controls, physical therapy responders, and physical therapy nonresponders were 9.32 +/- 0.68, 13.01 +/- 0.82, and 16.07 +/- 1.16 mm, respectively (data are mean +/- standard deviation). The correlation coefficients for tubercle deviation, chondromalacia patellae, and trochlear chondromalacia were 0.51 (P < 0.01), 0.44 (P < 0.01), and 0.28 (P < 0.05), respectively. On analysis of variance, tubercle deviation and chondromalacia patellae contributed significantly to prediction of AKP and response to physical therapy. The presence of chondromalacia patellae and a tubercle deviation greater than 14.6 mm is 100% specific and 67% sensitive with a positive predictive value of 100% and negative predictive value of 75% for failure of nonoperative management. Subjects with AKP have more laterally positioned tibial tubercles and are more likely to have patellar chondromalacia. Patients with AKP, chondromalacia patellae, and a tubercle deviation greater than 14.6 mm are unlikely to respond to nonoperative treatment. Knowledge of tibial tubercle lateralization and presence of chondromalacia patellae may assist clinicians in determining patient prognosis and selecting treatment options. C1 [Wittstein, Jocelyn R.; Garrett, William E., Jr.] Duke Univ, Med Ctr, Div Orthopaed Surg, Durham, NC 27710 USA. [O'Brien, Seth D.] Brooke Army Med Ctr, Dept Radiol, San Antonio, TX 78234 USA. [Vinson, Emily N.] Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA. RP Wittstein, JR (reprint author), Duke Univ, Med Ctr, Div Orthopaed Surg, Durham, NC 27710 USA. EM witts002@mc.duke.edu RI Vinson, Emily/O-1407-2015 NR 20 TC 12 Z9 14 U1 0 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0364-2348 J9 SKELETAL RADIOL JI Skeletal Radiol. PD SEP PY 2009 VL 38 IS 9 BP 895 EP 901 DI 10.1007/s00256-009-0698-6 PG 7 WC Orthopedics; Radiology, Nuclear Medicine & Medical Imaging SC Orthopedics; Radiology, Nuclear Medicine & Medical Imaging GA 474KD UT WOS:000268281300008 PM 19381628 ER PT J AU George, BJ Eichinger, JB Richard, TJ AF George, Benjamin J. Eichinger, Jessica B. Richard, Thomas J. TI A Rare Case of Aplastic Anemia Caused by Temozolomide SO SOUTHERN MEDICAL JOURNAL LA English DT Article DE aplastic anemia; chemotherapy; temozolomide; toxicity ID GLIOBLASTOMA; PATIENT AB A 65-year-old female patient with glioblastoma multiforme (GBM) developed aplastic anemia following treatment with temozolomide. Following her diagnosis of GBM, the patient received standard treatment with surgery, concomitant radiation therapy and temozolomide followed by adjuvant temozolomide. On day 14 of her adjuvant treatment, she developed profound fatigue and spontaneous bruising and was noted to be severely pancytopenic. After an extensive workup, she was found to have aplastic anemia on bone marrow bipsy. Further studies did not reveal any other etiology and she was not on any other medications known to cause aplastic anemia. There have been two previously published cases involving aplastic anemia due to temozolomide. This case represents a rare but potentially fatal toxicity from temozolomide. C1 [George, Benjamin J.; Eichinger, Jessica B.; Richard, Thomas J.] Brooke Army Med Ctr, Dept Hematol Oncol, Ft Sam Houston, TX 78234 USA. RP George, BJ (reprint author), San Antonio Mil Med Ctr S, Hematol Oncol SGOMH, 2200 Bergquist Dr,Ste 1, Lackland AFB, TX 78236 USA. EM benjamin.george@lackland.af.mil NR 11 TC 8 Z9 9 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 J9 SOUTH MED J JI South.Med.J. PD SEP PY 2009 VL 102 IS 9 BP 974 EP 976 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 496GN UT WOS:000269957800026 PM 19668033 ER PT J AU De Lucia, FC Gottfried, JL Munson, CA Miziolek, AW AF De Lucia, Frank C., Jr. Gottfried, Jennifer L. Munson, Chase A. Miziolek, Andrzej W. TI Current Status of Standoff LIBS Security Applications at the United States Army Research Laboratory SO SPECTROSCOPY LA English DT Article ID INDUCED BREAKDOWN SPECTROSCOPY; LASER-INDUCED FLUORESCENCE; TIME-DOMAIN SPECTROSCOPY; REMOTE DETECTION; UNIQUE SCHEME; IDENTIFICATION; EXPLOSIVES; DISCRIMINATION; CLASSIFICATION; SPECTROMETRY AB The United States Army Research Laboratory (ARL) has been applying standoff laser-induced breakdown spectroscopy (LIBS) to hazardous material detection and determination. We describe several standoff systems that have been developed by ARL and provide a brief overview of standoff LIBS progress at ARL. We also present some current standoff LIBS results from explosive residues on organic substrates and biomaterials from different growth media. These new preliminary results demonstrate that standoff LIBS has the potential to discriminate hazardous materials in more complex backgrounds. C1 [De Lucia, Frank C., Jr.; Gottfried, Jennifer L.; Munson, Chase A.; Miziolek, Andrzej W.] USA, Res Lab, AMSRD ARL WM BD, Aberdeen Proving Ground, MD USA. RP De Lucia, FC (reprint author), USA, Res Lab, AMSRD ARL WM BD, Aberdeen Proving Ground, MD USA. RI Gottfried, Jennifer/G-6333-2010; Munson, Chase/H-1667-2012 NR 53 TC 0 Z9 0 U1 1 U2 5 PU ADVANSTAR COMMUNICATIONS INC PI DULUTH PA 131 W 1ST STREET, DULUTH, MN 55802 USA SN 0887-6703 J9 SPECTROSCOPY-US JI Spectroscopy PD SEP PY 2009 SU S BP 29 EP 34 PG 6 WC Spectroscopy SC Spectroscopy GA 493UM UT WOS:000269763800016 ER PT J AU Kehe, K Thiermann, H Smith, WJ AF Kehe, Kai Thiermann, Horst Smith, William J. TI Bruno Papirmeister, 15 October 1925-30 March 2009 Obituary SO TOXICOLOGY LA English DT Biographical-Item C1 [Kehe, Kai; Thiermann, Horst] Bundeswehr Inst Pharmacol & Toxicol, D-80937 Munich, Germany. [Smith, William J.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Kehe, K (reprint author), Bundeswehr Inst Pharmacol & Toxicol, Neuherbergstr 11, D-80937 Munich, Germany. EM KaiKehe@bundeswehr.org NR 1 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0300-483X J9 TOXICOLOGY JI Toxicology PD SEP 1 PY 2009 VL 263 IS 1 BP 2 EP 2 DI 10.1016/j.tox.2009.03.004 PG 1 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 489HX UT WOS:000269412200002 ER PT J AU Anderson, DR Taylor, SL Fetterer, DP Holmes, WW AF Anderson, Dana R. Taylor, Stephanie L. Fetterer, David P. Holmes, Wesley W. TI Evaluation of protease inhibitors and an antioxidant for treatment of sulfur mustard-induced toxic lung injury SO TOXICOLOGY LA English DT Article DE Sulfur mustard; Lung injury; Pulmonary function; Treatment ID BIOCHEMICAL-ALTERATIONS; INHALATION; APROTININ; EXPOSURE; LAVAGE; INTOXICATION; LESIONS; SKIN; PIG AB Sulfur mustard (SM)-induced lung injury has been associated with protease activation, oxidative injury and inflammatory response culminating in tissue necrosis. The protease inhibitors aprotinin and ilomastat and the antioxidant trolox were evaluated for efficacy in ameliorating SM-induced lung injury. Anesthetized spontaneously breathing rats (N=6-8/group) were intratracheally intubated and exposed to 1.4 mg/kg SM (0.35 mg SM in 0.1 ml of ethanol) or ethanol alone by vapor inhalation for 50 min. At 1 min before the exposure rats were treated with one of the following: intravenous aprotinin, 4.4 mg/kg; intraperitoneal (ip) ilomastat, 25 mg/kg; or ip trolox, 500 mu g/kg. Aprotinin-treated animals received supplemental 2.2 mg/kg doses at 1 min and 6 h post-exposure (PE). A whole body plethysmograph system was used to monitor pulmonary function (PF) parameters for 1 h before exposure (baseline), and from 5-6 and 23-24 h post-exposure. SM inhalation caused significant increases in several PF parameters, including tidal volume, peak inspiratory flow, peak expiratory flow, end expiratory pause and enhanced pause. Consistent with the reported development of SM-induced pathology, these changes were minimal at the 5-6-h time and significant at the 23-24-h timepoint. At the later time it is known from previous work that airways are becoming obstructed with loose cellular debris, damaged cells and exudate, which contributed to the changes in PF parameters. Treatment with aprotinin or ilomastat eliminated these PF changes, yielding results comparable with controls for each of these parameters. Lung lavage fluid analysis showed that SM caused a significant increase in total protein (TP) and in the cytokines IL-1 alpha and IL-13. Aprotinin treatment prevented the increases in TP and IL-1 alpha production, ilomastat prevented the increased production of IL-13, and trolox treatment did not significantly prevent the SM-related increases in TP, IL-1 alpha or IL-13. Histopathologic examination of lung tissue 24 h post-exposure showed minimal alveolar effects caused by SM, while damage to bronchiolar regions was much more severe due to the highly reactive nature of SM. While aprotinin and ilomastat both alleviated the PF perturbations, surprisingly only aprotinin reduced the observed pathology, both grossly and histologically. These early results indicate that treatment with aprotinin and to a lesser extent ilomastat reduces some of the direct inflammatory response and damage associated with SM-induced lung injury. This research was supported by the Defense Threat Reduction Agency - Joint Science and Technology Office, Medical S&T Division. Published by Elsevier Ireland Ltd. C1 [Anderson, Dana R.; Fetterer, David P.; Holmes, Wesley W.] USA, Med Toxicol Branch, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Taylor, Stephanie L.] Univ Delaware, Sch Nursing, Newark, DE 19716 USA. RP Anderson, DR (reprint author), USA, Med Toxicol Branch, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM dana.r.anderson@us.army.mil; sltaylor@udel.edu; david.fetterer@us.army.mil; westey.w.holmes@us.army.mil NR 36 TC 27 Z9 32 U1 0 U2 2 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0300-483X J9 TOXICOLOGY JI Toxicology PD SEP 1 PY 2009 VL 263 IS 1 BP 41 EP 46 DI 10.1016/j.tox.2008.08.025 PG 6 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 489HX UT WOS:000269412200009 PM 18852015 ER PT J AU Graham, JS Stevenson, RS Mitcheltree, LW Hamilton, TA Deckert, RR Lee, RB Schiavetta, AM AF Graham, John S. Stevenson, Robert S. Mitcheltree, Larry W. Hamilton, Tracey A. Deckert, Robin R. Lee, Robyn B. Schiavetta, Ann M. TI Medical management of cutaneous sulfur mustard injuries SO TOXICOLOGY LA English DT Article DE Sulfur mustard; Wound healing; Pig; Skin; Treatment; Medical management ID HUMAN EPIDERMAL-KERATINOCYTES; IRANIAN VETERANS; LATE COMPLICATIONS; LASER DEBRIDEMENT; RANDOMIZED-TRIAL; SKIN-LESIONS; FIBRIN-GLUE; BURNS; WOUNDS; GAS AB Background: Sulfur mustard (2,2'-dichlorodiethyl sulfide; HD) is a potent vesicating chemical warfare agent that poses a continuing threat to both military and civilian populations. Significant cutaneous HD injuries can take several months to heal, necessitate lengthy hospitalizations, and result in long-term complications. There are currently no standardized or optimized methods of casualty management. New strategies are needed to provide for optimal and rapid wound healing. Objective: The primary aim of this research was to develop improved clinical strategies (treatment guidelines) for optimal treatment of superficial dermal (second degree) cutaneous HD injuries, with the goal of returning damaged skin to optimal appearance and normal function in the shortest period of time. Methods: Superficial dermal HD injuries were created on the ventral abdominal surface of weanling pigs. At 48 h post-exposure, lesions were laser debrided and a treatment adjunct applied. Cultured epithelial allografts and 11 commercial off-the-shelf (COTS) products were examined for their efficacy in improving wound healing of these injuries. Clinical evaluations and a variety of non-invasive bioengineering methods were used at 7 and 14 days post-surgery to follow the progress of wound healing and evaluate various cosmetic and functional properties of the wounds. Measurements included reflectance colorimetry to measure erythema: evaporimetry to examine transepidermal water loss as a method of evaluating barrier function; torsional ballistometry to evaluate the mechanical properties of skin firmness and elasticity; and two-dimensional high frequency ultrasonography (HFU) to monitor skin thickness (e.g., edema, scar tissue). Histopathology and immunohistochemistry were performed 14 days following surgery to examine structural integrity and quality of healing. Logical Decisions (R) for Windows was used to rank the 12 treatment adjuncts that were studied. Results: The most efficacious treatment adjuncts included (1) Vacuum Assisted Closure (TM), V.A.C.(R), involving application of topical negative pressure, (2) Amino-Plex (R) Spray (biO(2) Cosmeceuticals International, Inc., Beverly Hills, CA), a nutritive cosmeceutical product that is designed to increase oxygen in cells, stimulate ATP synthesis, improve glucose transportation, stimulate collagen formation, and promote angiogenesis, and (3) ReCell (R) Autologous Cell Harvesting Device (Clinical Cell Culture Americas LLC, Coral Springs. Florida), an innovative medical device that was developed to allow rapid harvesting of autologous cells from a thin split-thickness biopsy followed by spray application of a population of skin cells onto wounds within 30 min of collecting the biopsy, without the need of culturing the keratinocytes in a clinical laboratory. Conclusions: Complete re-epithelialization of debrided HD injuries in 7 days is possible. In general, shallow laser debridement through the basement membrane zone (100 mu m) appears to provide better results than deeper debridement (400 mu m) with respect to early re-epithelialization, cosmetic appearance, functional restoration, and structural integrity Of the 12 treatment adjuncts examined, the most promising included Vacuum Assisted Closur (TM), Amino-Plex (R) Spray, and ReCell (R) Autologous Cell Harvesting Device. Published by Elsevier Ireland Ltd. C1 [Graham, John S.; Stevenson, Robert S.; Deckert, Robin R.] USA, Med Toxicol Branch, Analyt Toxicol Div, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Mitcheltree, Larry W.; Hamilton, Tracey A.] USA, Comparat Pathol Branch, Div Comparat Med, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Lee, Robyn B.] USA, Program S3, Strategies & Operat Off, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Schiavetta, Ann M.] USA, Vet Med & Surg Branch, Div Comparat Med, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Graham, JS (reprint author), USA, Med Toxicol Branch, Analyt Toxicol Div, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM john.s.graham1@us.army.mil; rob.stevenson1@us.army.mil; larry.mitcheltree@us.army.mil; tracey.hamilton@us.army.mil; robin.deckert@us.army.mil; robyn.lee2@us.army.mil; ann.schiavetta@us.army.mil FU Plastic Surgery Associates of Northern Virginia, LTD, McLean, VA FX The authors wish to thank MAJ Stephen Dalal, D.V.M. and MAJ Ann Schiavetta's staff for veterinary support; F. Steven Tucker and staff for clinical pathology support; Jamie Martin and staff for histology support; and Bruce Freedman, MD, FACS (Plastic Surgery Associates of Northern Virginia, LTD, McLean, VA) for guidance in use of the Sciton Profile laser. NR 49 TC 22 Z9 23 U1 1 U2 8 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0300-483X J9 TOXICOLOGY JI Toxicology PD SEP 1 PY 2009 VL 263 IS 1 BP 47 EP 58 DI 10.1016/j.tox.2008.07.067 PG 12 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 489HX UT WOS:000269412200010 PM 18762227 ER PT J AU Smith, WJ AF Smith, William J. TI Therapeutic options to treat sulfur mustard poisoning-The road ahead SO TOXICOLOGY LA English DT Review DE Sulfur mustard; HD; Therapeutics; Treatments; Acute injury ID INJURY; MODEL AB For the past 15 years the international research community has conducted a basic and applied research program aimed at identifying a medical countermeasure against chemical threat vesicant, or blistering, agents. The primary emphasis of this program has been the development of therapeutic protection against sulfur mustard and its cutaneous pathology-blister formation. In addition to the work on a medical countermeasures, significant research has been conducted on the development of topical skin protectants and medical strategies for wound healing. This review will focus on the pharmacological strategies investigated, novel therapeutic targets currently under investigation and therapeutic approaches being considered for transition to advanced development. Additionally, we will review the expansion of our understanding of the pathophysiological mechanisms of mustard injury that has come from this research. While great strides have been made through these investigations, the complexity of the mustard insult demands that further studies extend the inroads made and point the way toward better understanding of cellular and tissue disruptions caused by sulfur mustard. Published by Elsevier Ireland Ltd. C1 USA, Div Res, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Smith, WJ (reprint author), USA, Div Res, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM william.j.smith3@us.army.mil NR 13 TC 16 Z9 19 U1 0 U2 0 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0300-483X J9 TOXICOLOGY JI Toxicology PD SEP 1 PY 2009 VL 263 IS 1 BP 70 EP 73 DI 10.1016/j.tox.2008.09.012 PG 4 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 489HX UT WOS:000269412200012 PM 18852011 ER PT J AU Cardo, LJ Wilder, D AF Cardo, L. J. Wilder, D. TI Platelet Activating Factor (PAF) Accumulates on Cell Membranes During RBC Storage and is Prevented by Leukofiltration at Collection SO TRANSFUSION LA English DT Meeting Abstract CT 62nd Annual Meeting of the American-Association-of-Blood-Banks CY OCT 24-27, 2009 CL New Orleans, LA SP Amer Assoc Blood Banks C1 [Cardo, L. J.; Wilder, D.] Walter Reed Army Inst Res, Silver Spring, MD USA. EM LISA.CARDO@US.ARMY.MIL NR 0 TC 1 Z9 1 U1 0 U2 1 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2009 VL 49 BP 12A EP 12A PG 1 WC Hematology SC Hematology GA 490XU UT WOS:000269542200029 ER PT J AU Hmel, P Andrist, JR Jemison, MC Perkins, JG Macdonald, VW AF Hmel, P. Andrist, J. R. Jemison, M. C. Perkins, J. G. Macdonald, V. W. TI In Vitro Characterization of Platelets Cryopreserved with 6% Dimethylsulfoxide SO TRANSFUSION LA English DT Meeting Abstract CT 62nd Annual Meeting of the American-Association-of-Blood-Banks CY OCT 24-27, 2009 CL New Orleans, LA SP Amer Assoc Blood Banks C1 [Hmel, P.; Andrist, J. R.; Jemison, M. C.; Perkins, J. G.; Macdonald, V. W.] Walter Reed Army Inst Res, Silver Spring, MD USA. EM peter.hmel@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2009 VL 49 BP 89A EP 89A PG 1 WC Hematology SC Hematology GA 490XU UT WOS:000269542200227 ER PT J AU Hmel, P Andrist, JR Jemison, MC Perkins, JG Macdonald, VW AF Hmel, P. Andrist, J. R. Jemison, M. C. Perkins, J. G. Macdonald, V. W. TI An In Vitro Assessment of Platelets Cryopreserved with 6% Dimethylsulfoxide Using the Thrombelastograph and Platelet Function Analyzer SO TRANSFUSION LA English DT Meeting Abstract CT 62nd Annual Meeting of the American-Association-of-Blood-Banks CY OCT 24-27, 2009 CL New Orleans, LA SP Amer Assoc Blood Banks C1 [Hmel, P.; Andrist, J. R.; Jemison, M. C.; Perkins, J. G.; Macdonald, V. W.] Walter Reed Army Inst Res, Silver Spring, MD USA. EM peter.hmel@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2009 VL 49 BP 91A EP 91A PG 1 WC Hematology SC Hematology GA 490XU UT WOS:000269542200232 ER PT J AU Cardo, LJ Wilder, D Hmel, P AF Cardo, L. J. Wilder, D. Hmel, P. TI EAS-81 Reduces Microparticle Production, but Not Phospholipid Procoagulant Potential of Filtered and Unfiltered Stored Red Cells SO TRANSFUSION LA English DT Meeting Abstract CT 62nd Annual Meeting of the American-Association-of-Blood-Banks CY OCT 24-27, 2009 CL New Orleans, LA SP Amer Assoc Blood Banks C1 [Cardo, L. J.; Wilder, D.; Hmel, P.] Walter Reed Army Inst Res, Silver Spring, MD USA. EM LISA.CARDO@US.ARMY.MIL NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2009 VL 49 BP 106A EP 107A PG 2 WC Hematology SC Hematology GA 490XU UT WOS:000269542200268 ER PT J AU Cardo, LJ Wilder, D AF Cardo, L. J. Wilder, D. TI Characterization of Leukofiltered and Unfiltered Red Cells in EAS-81 and AS5 Stored for 12 Weeks SO TRANSFUSION LA English DT Meeting Abstract CT 62nd Annual Meeting of the American-Association-of-Blood-Banks CY OCT 24-27, 2009 CL New Orleans, LA SP Amer Assoc Blood Banks C1 [Cardo, L. J.; Wilder, D.] Walter Reed Army Inst Res, Silver Spring, MD USA. EM LISA.CARDO@US.ARMY.MIL NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2009 VL 49 BP 108A EP 109A PG 2 WC Hematology SC Hematology GA 490XU UT WOS:000269542200273 ER PT J AU Cardo, LJ Wilder, D AF Cardo, L. J. Wilder, D. TI Platelet Activating Factor Acetylhydrolase (PAFase) Causes Hemolysis and Cell Membrane Disruption of Stored Red Cells SO TRANSFUSION LA English DT Meeting Abstract CT 62nd Annual Meeting of the American-Association-of-Blood-Banks CY OCT 24-27, 2009 CL New Orleans, LA SP Amer Assoc Blood Banks C1 [Cardo, L. J.; Wilder, D.] Walter Reed Army Inst Res, Silver Spring, MD USA. EM LISA.CARDO@US.ARMY.MIL NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2009 VL 49 SU 3 BP 187A EP 187A PG 1 WC Hematology SC Hematology GA 490XU UT WOS:000269542200491 ER PT J AU Cardo, LJ Wilder, D AF Cardo, L. J. Wilder, D. TI Platelet Activating Factor (PAF) on the Surface of, and in the Supernatant of, Stored Red Cells Is Derived from Platelets and Leukocytes SO TRANSFUSION LA English DT Meeting Abstract CT 62nd Annual Meeting of the American-Association-of-Blood-Banks CY OCT 24-27, 2009 CL New Orleans, LA SP Amer Assoc Blood Banks C1 [Cardo, L. J.; Wilder, D.] Walter Reed Army Inst Res, Silver Spring, MD USA. EM LISA.CARDO@US.ARMY.MIL NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2009 VL 49 SU 3 BP 187A EP 188A PG 2 WC Hematology SC Hematology GA 490XU UT WOS:000269542200492 ER PT J AU Cardo, LJ Wilder, D AF Cardo, L. J. Wilder, D. TI Neutrophil Priming by Supernatant of AS5 and EAS-81 Red Cells with and without Leukofiltration SO TRANSFUSION LA English DT Meeting Abstract CT 62nd Annual Meeting of the American-Association-of-Blood-Banks CY OCT 24-27, 2009 CL New Orleans, LA SP Amer Assoc Blood Banks C1 [Cardo, L. J.; Wilder, D.] Walter Reed Army Inst Res, Silver Spring, MD USA. EM LISA.CARDO@US.ARMY.MIL NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2009 VL 49 SU 3 BP 188A EP 189A PG 2 WC Hematology SC Hematology GA 490XU UT WOS:000269542200495 ER PT J AU Cardo, LJ Wilder, D AF Cardo, L. J. Wilder, D. TI Neutrophil Priming by Washed AS5 and EAS-81 Red Cells with and Without Leukofiltration SO TRANSFUSION LA English DT Meeting Abstract CT 62nd Annual Meeting of the American-Association-of-Blood-Banks CY OCT 24-27, 2009 CL New Orleans, LA SP Amer Assoc Blood Banks C1 [Cardo, L. J.; Wilder, D.] Walter Reed Army Inst Res, Silver Spring, MD USA. EM LISA.CARDO@US.ARMY.MIL NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2009 VL 49 SU 3 BP 188A EP 188A PG 1 WC Hematology SC Hematology GA 490XU UT WOS:000269542200494 ER PT J AU Cardo, LJ Wilder, D AF Cardo, L. J. Wilder, D. TI Red Cell Membrane Phospholipid Asymmetry with Extended Storage in AS5 and EAS-81 SO TRANSFUSION LA English DT Meeting Abstract CT 62nd Annual Meeting of the American-Association-of-Blood-Banks CY OCT 24-27, 2009 CL New Orleans, LA SP Amer Assoc Blood Banks C1 [Cardo, L. J.; Wilder, D.] Walter Reed Army Inst Res, Silver Spring, MD USA. EM LISA.CARDO@US.ARMY.MIL NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2009 VL 49 SU 3 BP 188A EP 188A PG 1 WC Hematology SC Hematology GA 490XU UT WOS:000269542200493 ER PT J AU Cardo, LJ Wilder, D AF Cardo, L. J. Wilder, D. TI Accumulation of Platelet Activating Factor (PAF) on Red Cells Stored in AS5 or EAS-81 is Equivalent and is Reduced by Leukofiltration SO TRANSFUSION LA English DT Meeting Abstract CT 62nd Annual Meeting of the American-Association-of-Blood-Banks CY OCT 24-27, 2009 CL New Orleans, LA SP Amer Assoc Blood Banks C1 [Cardo, L. J.; Wilder, D.] Walter Reed Army Inst Res, Silver Spring, MD USA. EM LISA.CARDO@US.ARMY.MIL NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2009 VL 49 BP 189A EP 189A PG 1 WC Hematology SC Hematology GA 490XU UT WOS:000269542200497 ER PT J AU McFaul, S Corley, J Mester, C AF McFaul, S. Corley, J. Mester, C. TI Supernate From Packed Blood Cells Activates Neutrophil Adhesive Properties SO TRANSFUSION LA English DT Meeting Abstract CT 62nd Annual Meeting of the American-Association-of-Blood-Banks CY OCT 24-27, 2009 CL New Orleans, LA SP Amer Assoc Blood Banks C1 [Mester, C.] Walter Reed Army Inst Res, Dept Blood Res, Silver Spring, MD USA. EM steve.mcfau@amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2009 VL 49 BP 189A EP 189A PG 1 WC Hematology SC Hematology GA 490XU UT WOS:000269542200496 ER PT J AU Polito, A O'Connell, R AF Polito, A. O'Connell, R. TI Performance and Thermostability of Rapid HIV 1/2 Kits for Screening Blood Donations Using Early HIV Positive Samples SO TRANSFUSION LA English DT Meeting Abstract CT 62nd Annual Meeting of the American-Association-of-Blood-Banks CY OCT 24-27, 2009 CL New Orleans, LA SP Amer Assoc Blood Banks C1 [Polito, A.] WHMC, LSQ SGVLB 59, San Antonio, TX USA. [O'Connell, R.] Walter Reed Army Inst Res, Rockville, MD USA. EM anthony.polito@lackland.af.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2009 VL 49 BP 215A EP 215A PG 1 WC Hematology SC Hematology GA 490XU UT WOS:000269542200561 ER PT J AU Duncan, R Fisher, C Riggs, LE Nagarkatti, R Nakhasi, HL Cardo, LJ AF Duncan, R. Fisher, C. Riggs, L. E. Nagarkatti, R. Nakhasi, H. L. Cardo, L. J. TI High Sensitivity, Pan-Species Detection of Leishmania Parasites in Blood Through Advances in Sample Preparation and Real-Time PCR SO TRANSFUSION LA English DT Meeting Abstract CT 62nd Annual Meeting of the American-Association-of-Blood-Banks CY OCT 24-27, 2009 CL New Orleans, LA SP Amer Assoc Blood Banks C1 [Duncan, R.; Nagarkatti, R.; Nakhasi, H. L.] US FDA, CBER, Rockville, MD 20857 USA. [Fisher, C.; Riggs, L. E.; Cardo, L. J.] Walter Reed Army Inst Res, Silver Spring, MD USA. EM robert.duncan@fda.hhs.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2009 VL 49 BP 232A EP 232A PG 1 WC Hematology SC Hematology GA 490XU UT WOS:000269542200607 ER PT J AU Thomas, S AF Thomas, S. TI Perspectives on dengue vaccine development and the potential role for disease control SO TROPICAL MEDICINE & INTERNATIONAL HEALTH LA English DT Meeting Abstract C1 [Thomas, S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1360-2276 J9 TROP MED INT HEALTH JI Trop. Med. Int. Health PD SEP PY 2009 VL 14 BP 26 EP 26 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 487HZ UT WOS:000269264000074 ER PT J AU Pritsch, M Saathoff, E Geldmacher, C Koehler, RN Koehler, RN Maboko, L Maganga, L Geis, S McCutchan, FE Kijak, GH Kim, JH Arroyo, MA Gerhardt, M Tovanabutra, S Robb, ML Williamson, C Michael, NL Hoelscher, M AF Pritsch, M. Saathoff, E. Geldmacher, C. Koehler, R. N. Koehler, R. N. Maboko, L. Maganga, L. Geis, S. McCutchan, F. E. Kijak, G. H. Kim, J. H. Arroyo, M. A. Gerhardt, M. Tovanabutra, S. Robb, M. L. Williamson, C. Michael, N. L. Hoelscher, M. TI Viral and host factors associated with high HIV-1 viral load setpoint in adult seroconverters from Mbeya Region, Tanzania SO TROPICAL MEDICINE & INTERNATIONAL HEALTH LA English DT Meeting Abstract C1 [Pritsch, M.; Saathoff, E.; Geldmacher, C.; Geis, S.; Gerhardt, M.; Hoelscher, M.] Univ Munich, Inst Infect Dis & Trop Med, Munich, Germany. [Koehler, R. N.; Koehler, R. N.; McCutchan, F. E.; Kijak, G. H.; Kim, J. H.; Arroyo, M. A.; Tovanabutra, S.; Robb, M. L.; Michael, N. L.] US Mil HIV Res Program MHRP, Rockville, MD USA. [Koehler, R. N.; Koehler, R. N.; McCutchan, F. E.; Kijak, G. H.; Tovanabutra, S.; Robb, M. L.] Henry M Jackson Fdn Advancement Mil Med, Rockville, MD USA. [Maboko, L.; Maganga, L.; Geis, S.; Gerhardt, M.] MMRP, Mbeya, Germany. [Kim, J. H.; Michael, N. L.] Walter Reed Army Inst Res, Rockville, MD USA. [Arroyo, M. A.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Williamson, C.] Univ Cape Town, Fac Hlth Sci, Div Med Virol, Inst Infect Dis & Mol Med, ZA-7925 Cape Town, South Africa. NR 0 TC 0 Z9 0 U1 0 U2 2 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1360-2276 J9 TROP MED INT HEALTH JI Trop. Med. Int. Health PD SEP PY 2009 VL 14 BP 34 EP 35 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 487HZ UT WOS:000269264000100 ER PT J AU Lin, A Kozar, MP O'Neil, MT Melendez, V Saunders, D Magill, AJ AF Lin, A. Kozar, M. P. O'Neil, M. T. Melendez, V. Saunders, D. Magill, A. J. TI Lead optimization and pre-clinical studies of imidazolidinedione derivatives as malaria prophylactic agents SO TROPICAL MEDICINE & INTERNATIONAL HEALTH LA English DT Meeting Abstract C1 [Lin, A.; Kozar, M. P.; O'Neil, M. T.; Melendez, V.; Saunders, D.; Magill, A. J.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. RI Kozar, Michael/A-9155-2011 NR 0 TC 1 Z9 1 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1360-2276 J9 TROP MED INT HEALTH JI Trop. Med. Int. Health PD SEP PY 2009 VL 14 BP 120 EP 120 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 487HZ UT WOS:000269264000336 ER PT J AU Lerdprom, R Rachaphaew, N Pinyorattanachote, A Srisajjarak, W Sirichaisinthop, J AF Lerdprom, R. Rachaphaew, N. Pinyorattanachote, A. Srisajjarak, W. Sirichaisinthop, J. TI Study of possibility to use the hemozoin for measuring the response of Plasmodium falciparum to antimalarial drug SO TROPICAL MEDICINE & INTERNATIONAL HEALTH LA English DT Meeting Abstract C1 [Lerdprom, R.; Srisajjarak, W.; Sirichaisinthop, J.] Vector Borne Dis Training Ctr, Bur Vector Borne Dis, Sara Buri, Thailand. [Rachaphaew, N.] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Pinyorattanachote, A.] Bur Dis Prevent & Control 9th Nakhonsrithammarat, Dept Vector Borne Dis, Nakhon Si Thammarat, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1360-2276 J9 TROP MED INT HEALTH JI Trop. Med. Int. Health PD SEP PY 2009 VL 14 BP 138 EP 138 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 487HZ UT WOS:000269264000389 ER PT J AU Moul, JW AF Moul, Judd W. TI Innovations in urology from military medicine Introduction SO UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS LA English DT Editorial Material ID GERM-CELL TUMORS; TESTICULAR CANCER; STAGE C1 [Moul, Judd W.] Duke Univ, Med Ctr, Div Urol Surg, Duke Prostate Ctr, Durham, NC 27706 USA. [Moul, Judd W.] USA, Washington, DC USA. RP Moul, JW (reprint author), Duke Univ, Med Ctr, Div Urol Surg, Duke Prostate Ctr, Durham, NC 27706 USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1078-1439 J9 UROL ONCOL-SEMIN ORI JI Urol. Oncol.-Semin. Orig. Investig. PD SEP-OCT PY 2009 VL 27 IS 5 BP 551 EP 552 DI 10.1016/j.urolonc.2009.01.022 PG 2 WC Oncology; Urology & Nephrology SC Oncology; Urology & Nephrology GA 494MF UT WOS:000269816700016 PM 19720301 ER PT J AU Hawksworth, DJ McLeod, DG Brassell, SA AF Hawksworth, Dorota J. McLeod, David G. Brassell, Stephen A. TI Advances made in the treatment of testicular cancer in the US Military: 1946 to the present SO UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS LA English DT Article DE Testis cancer; Urology; Pathologic classification; Retroperitoneal surgery; United States Military medical departments ID LYMPH-NODE DISSECTION; RETROPERITONEAL LYMPHADENECTOMY; TESTIS TUMORS; SEMINOMA; EVOLUTION AB Testicular cancer is presently one of the most curable solid tumors, and thanks to diagnostic, surgical, and medical advances over the last several decades, the treatment of this tumor serves as a paradigm for multimodal treatment of solid malignancies. Due to testicular cancer's predilection for younger patients, many of the seminal improvements and discoveries were made possible as a result of initial investigatory groundwork laid by military physicians treating servicemen. This article reviews historical contributions of the United States Military Medical Departments in the arena of testicular cancer treatment in the post-World War II era. Published by Elsevier Inc. C1 [Hawksworth, Dorota J.; McLeod, David G.; Brassell, Stephen A.] Walter Reed Army Med Ctr, Urol Serv, Washington, DC 20307 USA. RP Brassell, SA (reprint author), Walter Reed Army Med Ctr, Urol Serv, Washington, DC 20307 USA. EM stephen.brassell@amedd.army.mil NR 44 TC 0 Z9 1 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1078-1439 J9 UROL ONCOL-SEMIN ORI JI Urol. Oncol.-Semin. Orig. Investig. PD SEP-OCT PY 2009 VL 27 IS 5 BP 553 EP 557 DI 10.1016/j.urolonc.2009.01.024 PG 5 WC Oncology; Urology & Nephrology SC Oncology; Urology & Nephrology GA 494MF UT WOS:000269816700017 PM 19720302 ER PT J AU Brassell, SA Dobi, A Petrovics, G Srivastava, S McLeod, D AF Brassell, Stephen A. Dobi, Albert Petrovics, Gyorgy Srivastava, Shiv McLeod, David TI The center for prostate disease research (CPDR): A multidisciplinary approach to translational research SO UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS LA English DT Article DE Prostate cancer; Translational research; Center for prostate disease research ID CANCER CELLS; EXPRESSION; ANTIGEN; GROWTH; GENE; MEN AB This article describes the history, structure, and contributions of the Center for Prostate Disease Research. It divides the organization into the clinical program at Walter Reed Army Medical Center, the basic science program in Rockville, MD, and the multi-center national database. The emphasis of this article is not the achievements of the individual programs but their synergy, establishing a comprehensive multidisciplinary prostate center. Published by Elsevier Inc. C1 [Brassell, Stephen A.] Walter Reed Army Med Ctr, Ctr Prostate Dis Res, Washington, DC 20307 USA. Uniformed Univ Hlth Sci, Washington, DC 20307 USA. RP Brassell, SA (reprint author), Walter Reed Army Med Ctr, Ctr Prostate Dis Res, Washington, DC 20307 USA. EM Stephen.brassell@amedd.army.mil NR 15 TC 13 Z9 13 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1078-1439 J9 UROL ONCOL-SEMIN ORI JI Urol. Oncol.-Semin. Orig. Investig. PD SEP-OCT PY 2009 VL 27 IS 5 BP 562 EP 569 DI 10.1016/j.urolonc.2009.01.023 PG 8 WC Oncology; Urology & Nephrology SC Oncology; Urology & Nephrology GA 494MF UT WOS:000269816700019 PM 19720304 ER PT J AU Clausen, J Cramer, R Clough, S Gray, M Gwinn, P AF Clausen, Jay Cramer, Randall Clough, Stephen Gray, Michael Gwinn, Patrick TI Assessing the Sensitivity of Quantitative Structural Activity Analysis Models for Evaluating New Military Compounds SO WATER AIR AND SOIL POLLUTION LA English DT Article DE QSAR; EPI Suite (TM); Explosives; RDX; Perchlorate ID QSARS AB Quantitative structural activity relationship (QSAR) models are receiving wide use because of new regulations and public scrutiny regarding new compounds entered into commerce. Accordingly, the US Department of Defense (DoD) supported this study to evaluate QSAR modeling for energetic compounds. Four compounds proposed to replace ammonium perchlorate were examined: ammonium di(nitramido)amine (ADNA); 1,3,5,5-tetranitrohexahydropyrimidine (DNNC); 1,3,3,5,7,7-hexanitro-1,5-diazacyclooctane (HCO); and diammonium di(nitramido)dinitroethylene (ADNDNE). Currently used compounds were evaluated as analogues for those under development. Ammonium dinitramide (ADN) was the analogue for ADNA; hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) for DNNC; octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) for HCO; and 1,1-diamino-2,2-dinitroethene (FOX-7) for ADNDNE. QSAR analysis was performed with the US Environmental Protection Agency's Estimation Program Interface (EPI) Suite (TM). The comparison of model estimates to literature values ranged from good-to-poor. Results suggested the proposed replacement compounds have low aquatic toxicities and little potential to bioaccummulate, but the uncertainty in the predictions indicates QSAR modeling with EPI Suite (TM) is only useful for qualitative assessments of these proposed energetic compounds. C1 [Clausen, Jay] USA, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Cramer, Randall] USN, Ctr Surface Warfare, NAVSEA, Indian Head, MD 20640 USA. [Clough, Stephen] Haley & Aldrich Inc, Manchester, NH 03102 USA. [Gray, Michael] Woodard & Curran, Portland, ME 04102 USA. [Gwinn, Patrick] AMEC Earth & Environm Inc, Portland, ME 04101 USA. RP Clausen, J (reprint author), USA, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Jay.L.Clausen@usace.army.mil FU Strategic Environmental Research and Development Program (SERDP) [SERDP PP-1403] FX This research was performed as part of the Strategic Environmental Research and Development Program (SERDP) funded project SERDP PP-1403 "Synthesis, Evaluation, and Formulation Studies on New Oxidizers as Alternatives to Ammonium Perchlorate in Department of Defense (DoD) Missile Propulsion Applications" with M. Dewey, ATK Thiokol NR 17 TC 2 Z9 2 U1 2 U2 8 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0049-6979 J9 WATER AIR SOIL POLL JI Water Air Soil Pollut. PD SEP PY 2009 VL 202 IS 1-4 BP 141 EP 147 DI 10.1007/s11270-008-9964-9 PG 7 WC Environmental Sciences; Meteorology & Atmospheric Sciences; Water Resources SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences; Water Resources GA 483XT UT WOS:000269007400013 ER PT J AU Bantilan-Smith, M Bruland, GL MacKenzie, RA Henry, AR Ryder, CR AF Bantilan-Smith, Meris Bruland, Gregory L. MacKenzie, Richard A. Henry, Adonia R. Ryder, Christina R. TI A COMPARISON OF THE VEGETATION AND SOILS OF NATURAL, RESTORED, AND CREATED COASTAL LOWLAND WETLANDS IN HAWAI'I SO WETLANDS LA English DT Article DE creation; hydrologic gradient; invasive species; mitigation; restoration ID ORGANIC-MATTER; WATER WETLANDS; SALT-MARSH; MITIGATION; RESTORATION; SALINITY; PLANT; URBANIZATION; PENNSYLVANIA; PHOSPHORUS AB The loss of coastal wetlands throughout the Hawaiian Islands has increased the numbers of created (CW) and restored (RW) wetlands. An assessment of these wetlands has yet to occur, and it has not been determined whether CWs and RWs provide the same functions as natural wetlands (NWs). To address these concerns, vegetation and soil characteristics of 35 wetlands were compared within sites along hydrologic gradients and among sites with different surface water salinity and status (i.e., CW, RW, NW). Only 16 of 85 plant species identified were native and three of the four most abundant species were exotic. Vegetative characteristics differed primarily across salinity classes, then along hydrologic zones, and to a lesser extent among CWs, RWs, and NWs. Soil properties exhibited fewer differences across salinity classes and along hydrologic zones and greater differences among CWs, RWs, and NWs. The dominant presence of invasive species in coastal Hawaiian wetlands suggests that it will be difficult to locate reference sites that can be used as restoration targets. Differences in edaphic characteristics suggested that RWs/CWs do not exhibit the same functions as NWs. Future restoration and creation should include planting of native vegetation, controlling invasive vegetation, and alleviating inadequate soil conditions. C1 [Bantilan-Smith, Meris; Bruland, Gregory L.] Univ Hawaii, Dept Nat Resources & Environm Management, Honolulu, HI 96822 USA. [Bantilan-Smith, Meris] US Army Corps Engineers, Ft Shafter, HI 96858 USA. [MacKenzie, Richard A.] US Forest Serv, USDA, Inst Pacific Islands Forestry, Hilo, HI 96720 USA. [Henry, Adonia R.] US Fish & Wildlife Serv, Honolulu, HI 96850 USA. [Ryder, Christina R.] Ducks Unltd, Honolulu, HI 96822 USA. RP Bantilan-Smith, M (reprint author), Univ Hawaii, Dept Nat Resources & Environm Management, Honolulu, HI 96822 USA. EM bruland@hawaii.edu FU EPA FX We thank K. Peyton, Dr. D. Burney, M. Mitchell, T. Ka'iakapu, G. Blaich, Dr. D. Drigot, M. Silbernagle, S. Pelizza, D. Smith, J. Redunzle, G. Koob, H. deVries, A. Dibben- Young, S. Berkson, Dr. S. Fischer, G. Nakai, Dr. F. Duvall, D. Ivy, Dr. S. Beavers, R. Boston, J. Replogle, D. Riordan, and Propane Pete for help with sampling, site selection, and access, and Dr. D. Vasudevan, C. Browning, G. DeMent, D. Dunkell, C. Unser, B. Matatumua, and B. Bordeaux for field and laboratory assistance. N. Harbottle and the Bishop Museum Staff generously assisted with the plant identifications. Funding for this project was provided by the U. S. Environmental Protection Agency (EPA) Region IX Wetland Program Development Grant program. Although this research has been funded by the EPA, it has not been subjected to any EPA review and therefore does not necessarily reflect the views of the Agency, and no official endorsement should be inferred. NR 54 TC 15 Z9 16 U1 4 U2 25 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0277-5212 J9 WETLANDS JI Wetlands PD SEP PY 2009 VL 29 IS 3 BP 1023 EP 1035 PG 13 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA 535CO UT WOS:000272944400024 ER PT J AU McClung, JP Karl, JP Cable, SJ Williams, KW Young, AJ Lieberman, HR AF McClung, James P. Karl, J. Philip Cable, Sonya J. Williams, Kelly W. Young, Andrew J. Lieberman, Harris R. TI Longitudinal decrements in iron status during military training in female soldiers SO BRITISH JOURNAL OF NUTRITION LA English DT Article; Proceedings Paper CT Experimental Biology 2007 Annual Meeting CY APR 28-MAY 02, 2007 CL Washington, DC SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut DE Iron; Iron deficiency; Hepcidin; Training; Soldiers ID PREVIOUSLY UNTRAINED WOMEN; DEFICIENCY ANEMIA; PHYSICAL-ACTIVITY; BLOOD-LOSS; US-ARMY; EXERCISE; ADAPTATION; PREVALENCE; NUTRITION; ENDURANCE AB Fe is an essential micronutrient required for optimal cognitive and physical performance. Cross-sectional studies indicate that training degrades Fe status in female military personnel; however, longitudinal studies to measure the direct impact of military training on Fe status and performance have not been conducted. As Such, the objective of the present study was to determine the longitudinal effects of military training on Fe status in female soldiers. Fe status was assessed in ninety-four female soldiers immediately before and following a 9-week basic combat training (BCT) course. Fe status indicators included Hb, erythrocyte distribution width (RDW), serum ferritin, transferrin saturation and soluble transferrin receptor (sTfR). A 2-mile (3.2 km) run test was performed at the end of BCT to assess aerobic performance. Fe status was affected by BCT, as all Fe status indicators, excluding Hb, were diminished (P <= 0.01) at the end of BCT. Fe status indicators at the end of BCT (Hb and RDW) were associated (P <= 0.05) with running performance, as was the change in sTfR over the training period (r 0.320; P <= 0.05). In conclusion, Fe status in female soldiers is degraded during BCT, and degraded Fe status is associated with diminished aerobic performance. Female athletes and military personnel should strive to maintain Fe status to optimise physical performance. C1 [McClung, James P.; Karl, J. Philip; Young, Andrew J.; Lieberman, Harris R.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [Cable, Sonya J.; Williams, Kelly W.] Directorate Basic Combat Training, Ft Jackson, SC 29207 USA. RP McClung, JP (reprint author), USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. EM James.McClung@amedd.army.mil RI McClung, James/A-1989-2009; OI Karl, J. Philip/0000-0002-5871-2241 NR 37 TC 23 Z9 23 U1 1 U2 6 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 0007-1145 EI 1475-2662 J9 BRIT J NUTR JI Br. J. Nutr. PD AUG 28 PY 2009 VL 102 IS 4 BP 605 EP 609 DI 10.1017/S0007114509220873 PG 5 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 485RR UT WOS:000269141900020 PM 19173765 ER PT J AU Kalina, WV Warfield, KL Olinger, GG Bavari, S AF Kalina, Warren V. Warfield, Kelly L. Olinger, Gene G. Bavari, Sina TI Discovery of common marburgvirus protective epitopes in a BALB/c mouse model SO VIROLOGY JOURNAL LA English DT Article ID EBOLA-VIRUS INFECTION; T-CELL RESPONSES; HEMORRHAGIC-FEVER; GUINEA-PIGS; NONHUMAN-PRIMATES; DENDRITIC CELLS; GLYCOPROTEIN; PARTICLES; VACCINE; ANTIBODY AB Background: Marburg virus (MARV) causes acute hemorrhagic fever that is often lethal, and no licensed vaccines are available for preventing this deadly viral infection. The immune mechanisms for protection against MARV are poorly understood, but previous studies suggest that both antibodies and T cells are required. In our study, we infected BALB/c mice with plaque-purified, nonlethal MARV and used overlapping peptides to map H2(d)-restricted CD8+ T-cell epitopes. Methods: Splenocytes from mice infected with nonlethal MARV were harvested and stimulated with multiple overlapping 15-mer peptide pools, and reactive CD8+ T cells were evaluated for antigen specificity by measuring upregulation of CD44 and interferon-gamma expression. After confirming positive reactivity to specific 15-mer peptides, we used extrapolated 9-mer epitopes to evaluate the induction of cytotoxic T-cell responses and protection from lethal MARV challenge in BALB/c mice. Results: We discovered a CD8+ T-cell epitope within both the MARV glycoprotein (GP) and nucleoprotein (NP) that triggered cytotoxic T-cell responses. These responses were also protective when epitope-specific splenocytes were transferred into naive animals. Conclusion: Epitope mapping of MARV GP, NP, and VP40 provides the first evidence that specific MARV-epitope induction of cellular immune responses is sufficient to combat infection. Establishment of CD8+ T-cell epitopes that are reactive to MARV proteins provides an important research tool for dissecting the significance of cellular immune responses in BALB/c mice infected with MARV. C1 [Kalina, Warren V.; Warfield, Kelly L.; Bavari, Sina] USA, Med Res Inst Infect Dis, Div Bacteriol, Ft Detrick, MD 21702 USA. [Warfield, Kelly L.] Integrated Biotherapeut Inc, Germantown, MD 20876 USA. [Olinger, Gene G.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Kalina, Warren V.] Natl Biodef Anal & Countermeasures Ctr, Frederick, MD 21702 USA. RP Bavari, S (reprint author), USA, Med Res Inst Infect Dis, Div Bacteriol, Ft Detrick, MD 21702 USA. EM warren.kalina@amedd.army.mil; kelly@integratedbiotherapeutics.com; gene.olinger@amedd.army.mil; sina.bavari@amedd.army.mil OI Olinger, Gene/0000-0001-7338-0292 FU Defense Threat Reduction Agency, Joint Science and Technology Office-Chemical Biological Defense Program [1.1C0003_08_RD_B] FX We thank Jay Wells, Sean VanTongeren, and Meagan Cooper of the Bavari laboratory for technical support. Steven Bradfute and John Dye are acknowledged for helpful discussions and suggestions. We also thank Sarah Norris for compiling the statistical data. The research described herein was sponsored by the Defense Threat Reduction Agency, Joint Science and Technology Office-Chemical Biological Defense Program Proposal # 1.1C0003_08_RD_B (to SB). Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U. S. Army. NR 36 TC 6 Z9 6 U1 0 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-422X J9 VIROL J JI Virol. J. PD AUG 27 PY 2009 VL 6 AR 132 DI 10.1186/1743-422X-6-132 PG 9 WC Virology SC Virology GA 499GK UT WOS:000270205800001 PM 19712478 ER PT J AU Ervin, MH Dorsey, AM Salaets, NM AF Ervin, Matthew H. Dorsey, Andrew M. Salaets, Natalie M. TI Hysteresis contributions to the apparent gate pulse refreshing of carbon nanotube based sensors SO NANOTECHNOLOGY LA English DT Article ID FIELD-EFFECT TRANSISTORS; MEMORY AB We have fabricated back-gated carbon nanotube (CNT) field effect transistors (FET) and used them to sense NH(3) (ammonia) gas. After observing the long time required for the sensor to recover after being exposed to NH(3), we attempted to accelerate the sensor recovery by pulsing the gate electrode for a period of time at an appropriate bias. We have found that most, if not all, of the apparent sensor refreshing due to the gate pulse is actually a measurement artifact resulting from device hysteresis. C1 [Ervin, Matthew H.; Dorsey, Andrew M.; Salaets, Natalie M.] USA, Res Lab, AMSRD, ARL,SE,RL, Adelphi, MD 20783 USA. RP Ervin, MH (reprint author), USA, Res Lab, AMSRD, ARL,SE,RL, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM MErvin@ARL.Army.mil NR 13 TC 5 Z9 7 U1 0 U2 3 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND SN 0957-4484 J9 NANOTECHNOLOGY JI Nanotechnology PD AUG 26 PY 2009 VL 20 IS 34 AR 345503 DI 10.1088/0957-4484/20/34/345503 PG 6 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA 479NJ UT WOS:000268666100010 PM 19652277 ER PT J AU Duby, JM DiFurio, MJ AF Duby, Jeanne M. DiFurio, Megan J. TI Implementation of the Thinprep Imaging System in a Tertiary Military Medical Center SO CANCER CYTOPATHOLOGY LA English DT Article; Proceedings Paper CT 56th Annual Scientific Meeting of the American-Society-of-Cytopathology CY NOV 07-11, 2008 CL Orlando, FL SP Amer Soc Cytopathol DE atypical squamous cells of undetermined significance; liquid-based Papanicolaou test; high-risk human papillomavirus; ThinPrep Imaging System; cervical screening ID ATYPICAL SQUAMOUS-CELLS; UNDETERMINED SIGNIFICANCE; QUALITY-ASSURANCE; CYTOLOGY SLIDES; TRIAL; EXPERIENCE; SPECIMENS; SCREEN; HPV AB BACKGROUND: The ThinPrep Imaging System (TIS) was implemented at Brooke Army Medical Center (BAMC) in February 2006 and has been a crucial part of the ability of the Department of Pathology and Laboratory Services ability to improve efficiency and turnaround times for Papanicolaou (Pap) test reporting. The increased detection rate of squamous abnormalities, specifically high-grade squamous intraepithelial lesions (HSIL), has been well documented by many studies. In addition, the TIS has increased productivity for many laboratories. The objective of this study was to evaluate the effects of implementing the TIS at BAMC, a tertiary military medical center. Specifically, the following were assessed: 1) whether the detection of squamous abnormalities was increased with the TIS, 2) how the rate of high-risk human papillomavirus (HR-HPV) detection in atypical squamous cells (ASC) of undetermined significance (ASC-US) cases changed (or did not change) before and after implementation of the TIS, and 3) how the TIS influenced productivity. METHODS: All gynecologic cytology at BAMC has been collected and processed using the ThinPrep system since 2002. Before February 2006 and before implementation of the TIS, Pap tests were screened manually by the cytotechnologists. Detection rates of squamous abnormalities were compared between the period from February 2005 to December 2005 (manual screening) and the period from February 2006 to December 2006 (image-assisted screening). Squamous abnormalities included ASC-US; ASC, cannot rule out HSIL (ASC-H); low-grade squamous intraepithelial lesion (LSIL); HSIL; glandular abnormalities; and malignancies (squamous or glandular). In addition, the rates of HR-HPV-positive, HR-HPV-negative, and HR-HPV-quantity not sufficient were compared for the same periods. During both periods, testing for HR-HPV was performed only on ASC-US Pap tests. HR-HPV was tested with Digene Hybrid Capture 2 methodology. Productivity was calculated as the change in average slides screened per hour before and after imager implementation. RESULTS: In total, 107,647 Pap tests were analyzed in the 2005 (54,438 Pap tests) and 2006 (53,209 Pap tests) timeframes. Increases in the detection of ASC-H, atypical glandular cells (AGC), LSIL, and HSIL were statistically significant. The proportion of negative for intraepithelial lesion or malignancy (NILM) and unsatisfactory cases decreased significantly with implementation of the TIS. The ASC to squamous intraepithelial lesion (ASC:SIL) ratio decreased from 1.5 to 1.0 after TIS implementation. Decreases in the ASC-US HR-HPV-positive proportion and increases in the ASC-US HR-HPV-negative proportion after implementation of the TIS were statistically significant. In our laboratory, a 60% increase in productivity was noted with use of the TIS. CONCLUSIONS: Implementation of the TIS at BAMC significantly increased the detection of ASC-H, AGC, LSIL, and HSIL but had no significant impact on the ASC-US detection rate. Although the ASC-US rate did not change, both the HR-HPV-positive rate and the ASC:SIL ratio decreased. The data from the current study suggested that, at least initially, the use of imager-directed screening may increase the number of clinically insignificant ASC-US Pap tests. Cancer (Cancer Cytopathol) 2009;117:264-70. Published 2009 by the American Cancer Society.* C1 [Duby, Jeanne M.; DiFurio, Megan J.] Brooke Army Med Ctr, Dept Pathol & Lab Serv, Ft Sam Houston, TX 78234 USA. RP DiFurio, MJ (reprint author), Brooke Army Med Ctr, Dept Pathol MCHE PL, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM megan.difurio@amedd.army.mil NR 18 TC 13 Z9 16 U1 0 U2 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1934-662X J9 CANCER CYTOPATHOL JI Cancer Cytopathol. PD AUG 25 PY 2009 VL 117 IS 4 BP 264 EP 270 DI 10.1002/cncy.20033 PG 7 WC Oncology; Pathology SC Oncology; Pathology GA 484CX UT WOS:000269022000004 PM 19536887 ER PT J AU Crum-Cianflone, NF Hullsiek, KH Marconi, V Weintrob, A Ganesan, A Barthel, RV Fraser, S Agan, BK AF Crum-Cianflone, Nancy F. Hullsiek, Katherine H. Marconi, Vincent Weintrob, Amy Ganesan, Anuradha Barthel, Robert V. Fraser, Susan Agan, Brian K. TI Trends in the incidence of cancers among HIV-infected persons and the impact of antiretroviral therapy: authors' reply SO AIDS LA English DT Letter ID ANAL CANCER; COHORT; AIDS; RISK; IMMUNODEFICIENCY; MALIGNANCY; SMOKING C1 [Crum-Cianflone, Nancy F.; Hullsiek, Katherine H.; Marconi, Vincent; Weintrob, Amy; Ganesan, Anuradha; Barthel, Robert V.; Fraser, Susan; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, TriServ, AIDS Clin Consortium, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Crum-Cianflone, Nancy F.] USN, Infect Dis Clin, San Diego Med Ctr, San Diego, CA 92152 USA. [Hullsiek, Katherine H.] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Marconi, Vincent; Agan, Brian K.] San Antonio Mil Med Ctr, Infect Dis Clin, San Antonio, TX USA. [Weintrob, Amy] Walter Reed Army Med Ctr, Infect Dis Clin, Washington, DC 20307 USA. [Ganesan, Anuradha] USN, Med Ctr, Infect Dis Clin, Bethesda, MD 20814 USA. [Barthel, Robert V.] USN, Infect Dis Clin, Med Ctr Portsmouth, Portsmouth, VA USA. [Fraser, Susan] Tripler Army Med Ctr, Infect Dis Clin, Honolulu, HI 96859 USA. RP Crum-Cianflone, NF (reprint author), Uniformed Serv Univ Hlth Sci, TriServ, AIDS Clin Consortium, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. RI Marconi, Vincent/N-3210-2014; OI Marconi, Vincent/0000-0001-8409-4689; Agan, Brian/0000-0002-5114-1669 NR 12 TC 6 Z9 6 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 J9 AIDS JI Aids PD AUG 24 PY 2009 VL 23 IS 13 BP 1791 EP 1792 DI 10.1097/QAD.0b013e32832cb296 PG 2 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 488FF UT WOS:000269333900022 PM 19684484 ER PT J AU Muiva, LM Yenesew, A Derese, S Heydenreich, M Peter, MG Akala, HM Eyase, F Waters, NC Mutai, C Keriko, JM Walsh, D AF Muiva, Lois M. Yenesew, Abiy Derese, Solomon Heydenreich, Matthias Peter, Martin G. Akala, Hoseah M. Eyase, Fredrick Waters, Norman C. Mutai, Charles Keriko, Joseph M. Walsh, Douglas TI Antiplasmodial beta-hydroxydihydrochalcone from seedpods of Tephrosia elata SO PHYTOCHEMISTRY LETTERS LA English DT Article DE Tephrosia elata; Leguminosae; Seedpods; (S)-Elatadihydrochalcone; beta-Hydroxydihydrochalcone; Antiplasmodial activity AB From the seedpods of Tephrosia elata, a new beta-hydroxydihydrochalcone named (S)-elatadihydrochalcone was isolated. In addition, the known flavonoids obovatachalcone, obovatin, obovatin methyl ether and deguelin were identified. The structures were determined on the basis of spectroscopic evidence. The crude extract and the flavonoids obtained from the seedpods of this plant showed antiplasmodial activities. The literature NMR data on beta-hydroxydihydrochalcones is reviewed and the identity of some of the compounds assigned beta-hydroxydihydrochalcone skeleton is questioned. (C) 2009 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved. C1 [Muiva, Lois M.; Yenesew, Abiy; Derese, Solomon] Univ Nairobi, Dept Chem, Nairobi, Kenya. [Muiva, Lois M.; Keriko, Joseph M.] Jomo Kenyatta Univ Agr & Technol, Dept Chem, Nairobi, Kenya. [Heydenreich, Matthias; Peter, Martin G.] Univ Potsdam, Inst Chem, D-14415 Potsdam, Germany. [Akala, Hoseah M.; Eyase, Fredrick; Waters, Norman C.; Walsh, Douglas] USA, Med Res Unit Kenya, Walter Reed Project, APO, AE 09831 USA. [Mutai, Charles] Kenya Govt Med Res Ctr, Ctr Tradit Med & Drug Res, Nairobi, Kenya. RP Yenesew, A (reprint author), Univ Nairobi, Dept Chem, POB 30197-00100, Nairobi, Kenya. EM ayenesew@uonbi.ac.ke RI Derese, Solomon/H-5957-2016 OI Derese, Solomon/0000-0002-2640-3583 FU Deutsche Forschungsgemeinschaft, Germany [Pe 264/14-5]; Bundesministerium fuer Zusammenarbeit [Pe-264/14-6] FX We acknowledge support by the Deutsche Forschungsgemeinschaft, Germany, Grant No. Pe 264/14-5 and by the Bundesministerium fuer Zusammenarbeit, Grant No. Pe-264/14-6. Mr. P.C. Mutiso is highly appreciated for the identification of the plant material. NR 20 TC 18 Z9 19 U1 1 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1874-3900 J9 PHYTOCHEM LETT JI Phytochem. Lett. PD AUG 24 PY 2009 VL 2 IS 3 BP 99 EP 102 DI 10.1016/j.phytol.2009.01.002 PG 4 WC Plant Sciences; Chemistry, Medicinal SC Plant Sciences; Pharmacology & Pharmacy GA V16FM UT WOS:000207855500003 ER PT J AU Panchal, RG Bradfute, SB Peyser, BD Warfield, KL Ruthel, G Lane, D Kenny, TA Anderson, AO Raschke, WC Bavari, S AF Panchal, Rekha G. Bradfute, Steven B. Peyser, Brian D. Warfield, Kelly L. Ruthel, Gordon Lane, Douglas Kenny, Tara A. Anderson, Arthur O. Raschke, William C. Bavari, Sina TI Reduced Levels of Protein Tyrosine Phosphatase CD45 Protect Mice from the Lethal Effects of Ebola Virus Infection SO CELL HOST & MICROBE LA English DT Article ID T-CELL RESPONSES; HEMORRHAGIC-FEVER; MOUSE MODEL; GUINEA-PIGS; EXPRESSION; PATHOGENESIS; REGULATOR; KINASE; FAMILY; IMMUNODEFICIENCY AB Ebola virus (EBOV) infection of humans is a lethal but accidental dead-end event. Understanding resistance to EBOV in other species may help establish the basis of susceptibility differences among its hosts. Although rodents are resistant to EBOV, a murine-adapted variant is lethal when injected intraperitoneally into mice. We find that mice expressing reduced levels of the tyrosine phosphatase CD45 are protected against EBOV, whereas wild-type, CD45-deficient, or enzymatically inactive CD45-expressing mice succumbed to infection. Protection was dependent on CD8(+) T cells and interferon gamma. Reduced CD45-expressing mice retained greater control of gene expression and immune cell proliferation following EBOV infection, which contributed to reduced apoptosis, enhanced viral clearance, and increased protection against the virus. Together, these findings suggest that host susceptibility to EBOV is dependent on the delicate balance of immune homeostasis, which, as demonstrated here, can be determined by the levels of a single regulator. C1 [Panchal, Rekha G.; Bradfute, Steven B.; Peyser, Brian D.; Warfield, Kelly L.; Ruthel, Gordon; Anderson, Arthur O.; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Lane, Douglas; Kenny, Tara A.] NCI, SAIC Frederick Inc, Target Struct Based Drug Discovery Grp, Frederick, MD 21702 USA. [Raschke, William C.] Sidney Kimmel Canc Ctr, San Diego, CA 92121 USA. [Raschke, William C.] Virogenics Inc, Del Mar, CA 92104 USA. RP Panchal, RG (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA. EM rekha.panchal@amedd.army.mil; sina.bavad@amedd.army.mil OI Peyser, Brian/0000-0002-3455-5181 FU Defense Threat Reduction Agency; National Institute for Allergy and Infectious Diseases [R43 A1055102]; National Cancer Institute, National Institutes of Health [N01-CO-12400]; National Cancer Institute FX We thank Christine Mach, Sean Van Tongeren, Jay Wells, and Meagan Cooper for technical support and Dr. Javad Amen for critical review of the manuscript. This project has been funded by the Defense Threat Reduction Agency (to R.G.P. and S.B.) and the National Institute for Allergy and Infectious Diseases (grant R43 A1055102 to W.C.R.). This project has been funded, in whole or in part, with federal funds from the National Cancer Institute, National Institutes of Health, under contract N01-CO-12400. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. This research was supported, in part, by the Developmental Therapeutics Program in the Division of Cancer Treatment and Diagnosis of the National Cancer Institute. We would like to thank Oak Ridge Institute for Science and Engineering for participating in the Postgraduate Research Program at the U.S. Army Medical Research and Materiel Command. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. NR 45 TC 13 Z9 13 U1 0 U2 6 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 1931-3128 J9 CELL HOST MICROBE JI Cell Host Microbe PD AUG 20 PY 2009 VL 6 IS 2 BP 162 EP 173 DI 10.1016/j.chom.2009.07.003 PG 12 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA 487JK UT WOS:000269268900008 PM 19683682 ER PT J AU Fadare, O Clement, NF Ghofrani, M AF Fadare, Oluwole Clement, Nathan F. Ghofrani, Mohiedean TI High and intermediate grade ductal carcinoma in-situ of the breast: a comparison of pathologic features in core biopsies and excisions and an evaluation of core biopsy features that may predict a close or positive margin in the excision SO DIAGNOSTIC PATHOLOGY LA English DT Article ID SENTINEL NODE BIOPSY; CONSERVING SURGERY; INVASIVE DISEASE; LOCAL RECURRENCE; PREOPERATIVE DIAGNOSIS; INTRADUCTAL CARCINOMA; HISTOLOGICAL GRADE; RESIDUAL DISEASE; RE-EXCISION; TUMOR SIZE AB Low and high-grade ductal carcinoma in-situ (DCIS) are known to be highly disparate by a multitude of parameters, including progression potential, immunophenotype, gene expression profile and DNA ploidy. In this study, we analyzed a group of intermediate and high-grade DCIS cases to determine how well the core biopsy predicts the maximal pathology in the associated excisions, and to determine if there are any core biopsy morphologic features that may predict a close (<= 0.2 cm) or positive margin in the subsequent excision. Forty-nine consecutive paired specimens [core biopsies with a maximal diagnosis of DCIS, and their corresponding excisions, which included 20 and 29 specimens from mastectomies and breast conserving surgeries respectively] were evaluated in detail. In 5 (10%) of 49 cases, no residual carcinoma was found in the excision. In another 4 cases, the changes were diagnostic only of atypical ductal hyperplasia. There were 4 and 3 respective cases of invasive and microinvasive carcinoma out of the 49 excision specimens, for an overall invasion frequency of 14%. In 28 cases where a sentinel lymph node evaluation was performed, only 1 was found to be positive. Among the 40 cases with at least residual DCIS in the excision, there were 5 cases in which comedo-pattern DCIS was present in the excision but not in the core biopsy, attributed to the lower maximal nuclear grade in the biopsy proliferation in 4 cases and the absence of central necrosis in the 5(th). For the other main histologic patterns, in 8 (20%) of 40 cases, there were more patterns identified in the core biopsy than in the corresponding excision. For the other 32 cases, 100%, 66%, 50%, 33% and 25% of the number of histologic patterns in the excisions were captured in 35%, 5%, 17.5%, 15% and 7.5% of the preceding core biopsies respectively. Therefore, the core biopsy reflected at least half of the non-comedo histologic patterns in 77.5% of cases. In 6(15%) of the 40 cases, the maximum nuclear grade of the excision (grade 3) was higher than that seen in the core biopsy (grade 2). Overall, however, the maximum nuclear grade in the excision was significantly predicted by maximum nuclear grade in the core biopsy (p = 0.028), with a Phi of 0.347, indicating a moderately strong association. At a size threshold of 2.7 cm, there was no significant association between lesional size and core biopsy features. Furthermore, the clear margin width of the cases with lesional size <= 2.7 cm (mean 0.69 cm) was not significantly different (p = 0.4) from the cases with lesional size > 2.7 cm (mean 0.56 cm). Finally, among a variety of core biopsy features that were evaluated, including maximum nuclear grade, necrosis, cancerization of lobules, number of tissue cores with DCIS, number of DCIS ducts per tissue core, total DCIS ducts, or comedo-pattern, only necrosis was significantly associated with a positive or close (<= 0.2 cm) margin on multivariate analysis (Phi of 0.350). It is concluded that a significant change [to invasive disease (14%) or to no residual disease (10%)] is seen in approximately 24% of excisions that follow a core biopsy diagnosis of intermediate or high-grade DCIS. Core biopsy features are of limited value in predicting a close or positive margin in these lesions. C1 [Fadare, Oluwole; Clement, Nathan F.] Lackland AFB, Wilford Hall Med Ctr, Dept Pathol, San Antonio, TX USA. [Fadare, Oluwole] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX 78229 USA. [Clement, Nathan F.] Brooke Army Med Ctr, Dept Pathol, San Antonio, TX USA. [Clement, Nathan F.] Brooke Army Med Ctr, Lab Serv, San Antonio, TX USA. [Clement, Nathan F.] San Antonio Uniformed Serv Hlth Educ Consortium, Pathol Program, San Antonio, TX USA. [Ghofrani, Mohiedean] SW Washington Med Ctr, Dept Pathol, Vancouver, WA USA. RP Fadare, O (reprint author), Lackland AFB, Wilford Hall Med Ctr, Dept Pathol, San Antonio, TX USA. EM oluwolefadare@yahoo.com; nathan.clement@lackland.af.mil; mghofrani@yahoo.com NR 65 TC 4 Z9 5 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1746-1596 J9 DIAGN PATHOL JI Diagn. Pathol. PD AUG 19 PY 2009 VL 4 AR 26 DI 10.1186/1746-1596-4-26 PG 10 WC Pathology SC Pathology GA 493ZZ UT WOS:000269780200001 PM 19691836 ER PT J AU Linkov, I Steevens, J AF Linkov, Igor Steevens, Jeffery TI Risk assessment for nanomaterials: Challenges and management approaches SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Linkov, Igor; Steevens, Jeffery] USA, Engn Res & Dev Ctr, Brookline, MA 02446 USA. EM Igor.Linkov@usace.army.mil; Jeffery.A.Steevens@usace.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 22-AGRO BP 485 EP 485 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861900445 ER PT J AU Legler, PM Millard, CB AF Legler, Patricia M. Millard, Charles B. TI Oxidative regulation of S. cerevisiae S-formylglutathione hydrolase: Evidence for a novel mechanism of serine hydrolase regulation SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Legler, Patricia M.; Millard, Charles B.] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. EM patricia.legler@amedd.army.mil; charles.millard@amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 131-BIOL BP 738 EP 738 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861900650 ER PT J AU Compton, JR Legler, PM Olson, M Millard, CB AF Compton, Jaimee R. Legler, Patricia M. Olson, Mark Millard, Charles B. TI Improvement of a ricin vaccine immunogen (1-33/44-198) by introduction of an engineered disulfide bond SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Compton, Jaimee R.; Legler, Patricia M.; Millard, Charles B.] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. [Olson, Mark] USAMRIID, Dept Cell Biol & Biochem, Ft Detrick, MD 21702 USA. EM jaimee.compton@amedd.army.mil; patricia.legler@amedd.army.mil; charles.millard@amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 178-BIOL BP 744 EP 744 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861900656 ER PT J AU Legler, PM Millard, CB AF Legler, Patricia M. Millard, Charles B. TI Directed evolution of B.subtilis p-nitrobenzyl esterase for the enhancement of choline ester and organophosphate hydrolysis SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Legler, Patricia M.; Millard, Charles B.] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. EM patricia.legler@amedd.army.mil; charles.millard@amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 139-BIOL BP 749 EP 749 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861900661 ER PT J AU Allen, JL Jow, TR Wolfenstine, J AF Allen, Jan L. Jow, T. Richard Wolfenstine, Jeff TI Preparation and properties of lithium cobalt phosphate for lithium-ion batteries SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Allen, Jan L.; Jow, T. Richard; Wolfenstine, Jeff] USA, Electrochem Branch, Res Lab, Adelphi, MD 20783 USA. EM jan.allen@us.army.mil NR 0 TC 0 Z9 0 U1 1 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 665-INOR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HZ UT WOS:000207862000664 ER PT J AU Andzelm, J Rinderspacher, BC Rawlett, AM Dougherty, J Baer, R Govind, N AF Andzelm, Jan Rinderspacher, B. Christopher Rawlett, Adam M. Dougherty, Joseph Baer, Roi Govind, Niranjan TI Predicting absorption spectra and NLO properties of organic dyes SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Andzelm, Jan; Rinderspacher, B. Christopher; Rawlett, Adam M.; Dougherty, Joseph] USA, Div Mat, Multifunct Mat Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Baer, Roi] Hebrew Univ Jerusalem, Dept Phys Chem, Lise Meitner Minerva Ctr Quantum Chem, IL-91904 Jerusalem, Israel. [Govind, Niranjan] Pacific NW Natl Lab, Richland, WA 99352 USA. EM jandzelm@arl.army.mil; arawlett@arl.army.mil; roi.baer@huji.ac.il RI Govind, Niranjan/D-1368-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 613-ORGN PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861908594 ER PT J AU Andzelm, JW Walker, J Schreuder-Gibson, H Gibson, P AF Andzelm, Jan W. Walker, John Schreuder-Gibson, Heidi Gibson, Phillip TI Reactivity of DFP in water saturated polymer membrane SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Andzelm, Jan W.] USA, Multifunct Mat Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Walker, John; Schreuder-Gibson, Heidi; Gibson, Phillip] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. EM jandzelm@arl.army.mil RI Gibson, Phillip/D-2398-2010 OI Gibson, Phillip/0000-0002-6172-4438 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 171-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861904116 ER PT J AU Bednar, AJ Jones, WT Kirgan, RA Kennedy, AJ Johnson, DR Ranville, JF Chappell, MA Steevens, JA AF Bednar, Anthony J. Jones, W. T. Kirgan, R. A. Kennedy, A. J. Johnson, D. R. Ranville, J. F. Chappell, M. A. Steevens, J. A. TI ANYL 289-Investigations of metal nanoparticles in soil and tissue by field-flow fractionation interfaced to inductively coupled plasma mass spectrometry SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Bednar, Anthony J.; Jones, W. T.; Kirgan, R. A.] USA, Environm Chem Branch, EP C, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Kennedy, A. J.; Johnson, D. R.; Steevens, J. A.] USA, Risk Assessment Branch, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Ranville, J. F.] Colorado Sch Mines, Dept Chem & Geochem, Golden, CO 80401 USA. [Chappell, M. A.] USA, Environm Proc Branch, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM Anthony.J.Bednar@erdc.usace.army.mil; jranvill@mines.edu RI Ranville, James/H-1428-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 289-ANYL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861901368 ER PT J AU Berg, MC Mrozek, RA Strawhecker, K VanLandingham, M Andzelm, JW Sliozberg, YR Lenhart, JL AF Berg, Michael C. Mrozek, Randy A. Strawhecker, Kenneth VanLandingham, Mark Andzelm, Jan W. Sliozberg, Yelena R. Lenhart, Joseph L. TI POLY 100-Tuning the properties of nanocomposite thermoplastic elastomer gels through filler size and surface chemistry SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Berg, Michael C.; Mrozek, Randy A.; Strawhecker, Kenneth; VanLandingham, Mark; Andzelm, Jan W.; Sliozberg, Yelena R.; Lenhart, Joseph L.] USA, Multifunct Mat Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM mike.berg@arl.army.mil; randy.mrozek@arl.army.mil; kenneth.strawhecker@arl.army.mil; mvanlandingham@arl.army.mil; jandzelm@arl.army.mil; yelena.r.sliozberg@arl.army.mil; joseph.lenhart1@arl.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 100-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861906421 ER PT J AU Bevilacqua, VLH Madren-Whalley, JS Rice, JS Reilly, LM Rogers, TJ Schenning, A AF Bevilacqua, Vicky L. H. Madren-Whalley, Janna S. Rice, Jeffrey S. Reilly, Lisa M. Rogers, Thomas J. Schenning, Amanda TI Ricin and staphylococcal enterotoxin B stability: Heat and chlorine treatment SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Bevilacqua, Vicky L. H.] USA, Point Detect Branch, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Madren-Whalley, Janna S.] USA, Mol Engn Branch, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Rice, Jeffrey S.] Elona Biotechnol Inc, Greenwood, IN 46143 USA. [Reilly, Lisa M.] Bethany Coll, Dept Chem, Bethany, WV 26032 USA. [Rogers, Thomas J.] Temple Univ, Sch Med, Dept Pharmacol, Philadelphia, PA 19140 USA. [Schenning, Amanda] SAIC Corp, Gunpowder, MD 21010 USA. EM vicky.bevilacqua@us.army.mil; janna.s.madrenwhalley@us.army.mil; Jrice@elonabiotech.com; lreilly@bethanywv.edu; rogerst@temple.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 442-INOR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HZ UT WOS:000207862000066 ER PT J AU Bouldin, R Ravichandran, S Garhwal, R Nagarajan, S Kumar, J Bruno, FF Samuelson, L Nagarajan, R AF Bouldin, Ryan Ravichandran, Sethumadhavan Garhwal, Rahul Nagarajan, Subhalakshmi Kumar, Jayant Bruno, Ferdinando F. Samuelson, Lynne Nagarajan, Ramaswamy TI POLY 595-Enzymatically synthesized water-soluble polypyrrole SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Bouldin, Ryan] Univ Massachusetts, Dept Chem Engn, Lowell, MA 01854 USA. [Ravichandran, Sethumadhavan; Garhwal, Rahul; Nagarajan, Subhalakshmi] Univ Massachusetts, Dept Chem, Lowell, MA 01854 USA. [Kumar, Jayant] Univ Massachusetts, Dept Phys, Ctr Adv Mat, Lowell, MA 01854 USA. [Bruno, Ferdinando F.; Samuelson, Lynne] USA, Natick Soldier Ctr, RDECOM, Natick, MA 01760 USA. [Nagarajan, Ramaswamy] Univ Massachusetts, Dept Plast Engn, Ctr Adv Mat, Lowell, MA 01854 USA. EM ryan_bouldin@student.uml.edu; rsethu4u@gmail.com; Jayant_Kumar@uml.edu; Ferdinando_bruno@uml.edu; Lynne_Samuelson@uml.edu; Ramaswamy_Nagarajan@uml.edu NR 0 TC 1 Z9 1 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 595-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861906523 ER PT J AU Butkus, MA Johnson, M Dacunto, P Lynch, J AF Butkus, Michael A. Johnson, Marie Dacunto, Phillip Lynch, Jason TI ENVR 134-Transport properties of lead phosphate aggregates formed on shooting ranges SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Butkus, Michael A.; Johnson, Marie; Dacunto, Phillip; Lynch, Jason] US Mil Acad, Dept Geog & Environm Engn, West Point, NY 10996 USA. EM Michael.Butkus@usma.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 134-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861903557 ER PT J AU Campbell, AJ Legler, P Millard, C Friedlander, AM AF Campbell, Amy J. Legler, Patricia Millard, Charles Friedlander, Arthur M. TI Isomerization of a glutamyl-vinyl sulfone to the corresponding allyl sulfone SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Campbell, Amy J.; Legler, Patricia] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. [Millard, Charles; Friedlander, Arthur M.] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. EM amy.j.campbell@amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 469-ORGN PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861908071 ER PT J AU Chappell, M Scheckel, KG Hennessy, J Jacobi, M Porter, B Price, CL George, AJ Ford, L AF Chappell, Mark Scheckel, Kirk G. Hennessy, Joel Jacobi, Michael Porter, Beth Price, Cynthia L. George, Aaron J. Ford, Lesley TI GEOC 48-Characterization of soil mercury in contaminated soils and sediments: Implications for in situ immobilization SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Chappell, Mark; Price, Cynthia L.] US Army Corps Engineers, Soil & Sediment Geochem Environm Lab, Vicksburg, MS 39180 USA. [Scheckel, Kirk G.] US EPA, Waste Management Branch, Cincinnati, OH 45224 USA. [Hennessy, Joel; Jacobi, Michael] US EPA, Philadelphia, PA 19103 USA. [Porter, Beth; George, Aaron J.; Ford, Lesley] SpecPro Inc, Huntsville, AL 35805 USA. EM scheckel.kirk@epa.gov; hennessy.joel@epa.gov; jacobi.mike@epa.gov; cynthia.l.price@usace.army.mil; aaronj.george@usace.army.mil; Lesley.S.Ford@usace.army.mil RI Scheckel, Kirk/C-3082-2009 OI Scheckel, Kirk/0000-0001-9326-9241 NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 48-GEOC PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861902753 ER PT J AU Creasy, WR McGarvey, DJ Fry, R Durst, HD AF Creasy, William R. McGarvey, David J. Fry, Roderick Durst, H. D. TI Chemical warfare agent reaction studies using headspace GC/MS and high resolution magic angle spinning (HRMAS) NMR SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Creasy, William R.; Fry, Roderick] SAIC, Apg Edgewood, MD 21010 USA. [McGarvey, David J.] USA, Edgewood Chem Biolg Ctr, Aberdeen Proving Ground, MD 21010 USA. [Durst, H. D.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM william.creasy@us.army.mil; david.mcgarvey@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 729-INOR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HZ UT WOS:000207862000621 ER PT J AU Cureton, LT Lane, OR Beyer, FL Turner, SR AF Cureton, LaShonda T. Lane, Ozma R. Beyer, Frederick L. Turner, S. Richard TI Optical and morphological properties of hexafluoroisopropylidene bisphenol poly(arylene ether sulfone) segmented copolymers SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Cureton, LaShonda T.; Lane, Ozma R.; Turner, S. Richard] Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA. [Cureton, LaShonda T.; Lane, Ozma R.; Turner, S. Richard] Virginia Polytech Inst & State Univ, MII, Blacksburg, VA 24061 USA. [Beyer, Frederick L.] USA, Div Mat, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM clashon@vt.edu; olane@vt.edu; flbeyer@arl.army.mil; srturner@vt.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 498-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861905391 ER PT J AU Dirlam, PT Strange, GA Orlicki, JA Wetzel, ED Costanzo, PJ AF Dirlam, Philip T. Strange, Gregory A. Orlicki, Joshua A. Wetzel, Eric D. Costanzo, Philip J. TI Development of self-pressurizing capillaries using Diels-Alder chemistry SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Dirlam, Philip T.; Strange, Gregory A.; Costanzo, Philip J.] Calif Polytech State Univ San Luis Obispo, Dept Chem & Biochem, San Luis Obispo, CA 93407 USA. [Orlicki, Joshua A.; Wetzel, Eric D.] USA, Res Lab, Div Mat, Multifunct Mat Branch, Aberdeen Proving Ground, MD 21005 USA. EM pdirlam@calpoly.edu; jorlicki@arl.army.mil; pcostanz@calpoly.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 47-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861905464 ER PT J AU Durst, HD Sumpter, K Brown, RS Neverov, AA Andrea, T AF Durst, H. Dupont Sumpter, Kenneth Brown, R. Stan Neverov, Alexei A. Andrea, Tamer TI Metal ion-catalyzed alcoholysis as a strategy for the high loading destruction of CW organophosphorus agents SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Durst, H. Dupont] USA, ECBC, Aberdeen Proving Ground, MD 21010 USA. [Sumpter, Kenneth] ECBC RDECOM, Aberdeen Proving Ground, MD 21010 USA. [Brown, R. Stan; Neverov, Alexei A.; Andrea, Tamer] Queens Univ, Dept Chem, Kingston, ON K7L 3N6, Canada. EM horatio.d.durst@us.army.mil; rsbrown@chem.queensu.ca; an4@post.queensu.ca NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 396-INOR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HZ UT WOS:000207862000162 ER PT J AU Finch, AS Mackie, TD Sund, CJ Sumner, JJ AF Finch, Amethist S. Mackie, Timothy D. Sund, Christian J. Sumner, James J. TI Tracking metabolic processes of Clostridium acetobutylicum during fermentation via a microbial fuel cell SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Finch, Amethist S.; Mackie, Timothy D.; Sund, Christian J.; Sumner, James J.] USA, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA. EM timothy.mackie@us.army.mil; christian.sund@us.army.mil; james.sumner1@arl.army.mil RI sund, christian/G-3424-2013; Finch, Amethist/H-9510-2013 OI Finch, Amethist/0000-0002-4650-6301 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 88-FUEL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861905150 ER PT J AU Forsythe, E Shi, JM Morton, DC Loy, D Lee, YK Colaneri, N O'Rourke, S Silvernail, J Rajan, K Hack, M Brown, JJ AF Forsythe, Eric Shi, Jianmin Morton, David C. Loy, Doug Lee, Yong Kyun Colaneri, Nick O'Rourke, Shawn Silvernail, Jeff Rajan, Kamala Hack, Mike Brown, Julie J. TI POLY 85-Future flexible OLED displays for army applications SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Forsythe, Eric; Shi, Jianmin; Morton, David C.] USA, Res Lab, Adelphi, MD 20783 USA. [Loy, Doug; Lee, Yong Kyun; Colaneri, Nick; O'Rourke, Shawn] Arizona State Univ, Flexible Display Ctr, Tempe, AZ 85284 USA. [Silvernail, Jeff; Rajan, Kamala; Hack, Mike; Brown, Julie J.] Universal Display Corp, Ewing, NJ USA. EM eforsythe@arl.army.mil; david.morton1l@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 85-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861906317 ER PT J AU Glaspell, GP Wilkins, JR Anderson, JE AF Glaspell, Garry P., II Wilkins, James R. Anderson, John E. TI FLUO 7-Synthesis of magnetic upconverting nanoparticles utilizing a NaYF4 lattice SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Glaspell, Garry P., II; Wilkins, James R.] USA, Topog Engn Ctr, Engn Res & Dev Ctr, Alexandria, VA 22315 USA. [Anderson, John E.] USA, ERDC, Alexandria, VA 22315 USA. EM gglaspell@gmail.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 7-FLUO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861903781 ER PT J AU Guicheteau, J Fountain, AW Christesen, S Emmons, E Tripathi, A AF Guicheteau, Jason Fountain, Augustus W., III Christesen, Steven Emmons, Erik Tripathi, Ashish TI COLL 370-Research applications of surface-enhanced Raman at the US Army Edgewood Chemical Biological Center SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Guicheteau, Jason; Fountain, Augustus W., III; Christesen, Steven] AMSRD ECB RT, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Emmons, Erik] USA, Natl Res Council Associate, ECBC Res Lab, AMSRD ECB RT, Aberdeen Proving Ground, MD 21010 USA. [Tripathi, Ashish] SAIC, AMSRD ECB RT DL, Aberdeen Proving Ground, MD 21010 USA. EM jason.guicheteau@us.army.mil; augustus-fountain@us.army.mil; Steven.christesen@us.army.mil; erik.emmons@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 370-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861903182 ER PT J AU Holthoff, EL Stratis-Cullum, DN Hankus, ME Pellegrino, PM AF Holthoff, Ellen L. Stratis-Cullum, Dimitra N. Hankus, Mikella E. Pellegrino, Paul M. TI ANYL 57-Nanosensor for explosives' detection based on molecularly imprinted polymers and surface enhanced Raman scattering SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Holthoff, Ellen L.; Stratis-Cullum, Dimitra N.; Hankus, Mikella E.; Pellegrino, Paul M.] USA, Electroopt & Photon Div, Res Lab, Adelphi, MD 20783 USA. EM ellen.holthoff@us.army.mil; dimitra.stratiscullum1@us.army.mil; mikella.hankus@arl.army.mil; ppellegr@arl.army.mil RI Hankus, Mikella/A-9005-2012 NR 0 TC 0 Z9 0 U1 1 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 57-ANYL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861901164 ER PT J AU Huang, LH Chen, RR Xie, J Hsu, A Chu, D AF Huang, Lihong Chen, Rongrong Xie, Jian Hsu, Andrew Chu, Deryn TI Hydrogen production via autothermal reforming of bioethanol over improved Ni-based catalysts SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Huang, Lihong; Chen, Rongrong; Xie, Jian; Hsu, Andrew] Indiana Univ Purdue Univ, Richard G Lugar Ctr Renewable Energy, Indianapolis, IN 46202 USA. [Chu, Deryn] USA, Res Labs, Adelphi, MD 20783 USA. EM lihhuang@iupui.edu; rochen@iupui.edu; jianxie@iupui.edu; anhsu@iupui.edu; dchu@arl.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 1-FUEL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861905030 ER PT J AU Kholod, Y Gorb, L Hill, F Leszczynski, J AF Kholod, Yana Gorb, Leonid Hill, Frances Leszczynski, Jerzy TI ENVR 212-Quantum chemistry applications for environmental science: Evaluation of military produced contaminants SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Kholod, Yana; Leszczynski, Jerzy] Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA. [Gorb, Leonid; Hill, Frances] USA, Erdc, Vicksburg, MS 39180 USA. EM yana@icnanotox.org; lgorb@ccmsi.us; Frances.C.Hill@usace.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 212-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861903639 ER PT J AU Kiserow, D AF Kiserow, Douglas TI POLY 235-Polymer research in the army: Areas of interest and funding opportunities SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Kiserow, Douglas] USA, Res Off, Div Chem Sci, Res Triangle Pk, NC 27709 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 235-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861906003 ER PT J AU Koku, H Czymmek, KJ Schure, MR Maier, RS Lenhoff, AM AF Koku, Harun Czymmek, Kirk J. Schure, Mark R. Maier, Robert S. Lenhoff, Abraham M. TI BIOT 420-Structure-based modeling of flow and dispersion in a polymeric monolith SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Koku, Harun; Lenhoff, Abraham M.] Univ Delaware, Dept Chem Engn, Newark, DE 19716 USA. [Czymmek, Kirk J.] Univ Delaware, Delaware Biotechnol Inst, Newark, DE 19716 USA. [Schure, Mark R.] Rohm & Haas Co, Theoret Separat Sci Lab, Spring House, PA 19477 USA. [Maier, Robert S.] USA, Informat Technol Lab, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. EM kirk@udel.edu; schure@rohmhaas.com; lenhoff@udel.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 420-BIOT PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861901735 ER PT J AU Lenhart, JL Klein, RJ AF Lenhart, Joseph L. Klein, Robert J. TI Porous epoxies by reaction induced phase separation with a removable alcohol poragen SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Lenhart, Joseph L.] USA, Multifunct Mat Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Klein, Robert J.] Sandia Natl Labs, Organ Mat Dept, Albuquerque, NM 87185 USA. EM joseph.lenhart1@arl.army.mil; rklein@sandia.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 67-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861905691 ER PT J AU Lenhart, JL Mrozek, RA Berg, MC VanLandingham, M Strawhecker, K Andzelm, JW Sliozberg, YR Bundy, M Cole, PJ Shull, KR Otim, K AF Lenhart, Joseph L. Mrozek, Randy A. Berg, Michael C. VanLandingham, Mark Strawhecker, Kenneth Andzelm, Jan W. Sliozberg, Yelena R. Bundy, Mark Cole, Phillip J. Shull, Kenneth R. Otim, Katie TI Hierarchically structured soft polymer composites and nonaqueous polymer gels for multifunctional materials SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Lenhart, Joseph L.; Mrozek, Randy A.; Berg, Michael C.; VanLandingham, Mark; Strawhecker, Kenneth; Andzelm, Jan W.; Sliozberg, Yelena R.; Bundy, Mark] USA, Multifunct Mat Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Cole, Phillip J.] Sandia Natl Labs, Albuquerque, NM 87185 USA. [Shull, Kenneth R.; Otim, Katie] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA. EM joseph.lenhart1@arl.army.mil; randy.mrozek@arl.army.mil; mike.berg@arl.army.mil; mvanlandingham@arl.army.mil; kenneth.strawhecker@arl.army.mil; jandzelm@arl.army.mil; yelena.r.sliozberg@arl.army.mil; pjcole@sandia.gov; k-shull@northwestern.edu NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 159-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861905678 ER PT J AU Li, K Chen, Y Li, SQ Niu, ZW You, SJ Mello, CM Lu, XB Wang, Q AF Li, Kai Chen, Yi Li, Siqi Niu, Zhongwei You, Shaojin Mello, Charlene M. Lu, Xiao-Bing Wang, Qian TI Dual modification of M13 bacteriophage and its application for cell imaging SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Li, Kai; Lu, Xiao-Bing] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China. [Chen, Yi; Li, Siqi; Niu, Zhongwei; Wang, Qian] Univ S Carolina, Dept Chem & Biochem, Columbia, SC 29208 USA. [You, Shaojin] Atlanta Res & Educ Fdn, Atlanta VA Med Ctr, Decatur, GA 30033 USA. [Mello, Charlene M.] USA, Res Dev & Engn Command, Natick Soldiers Ctr, Natick, MA 01760 USA. EM likai2003@gmail.com; yichen66_star@yahoo.com; niu.z@mail.chem.sc.edu; Shaojin.You@va.gov; charlene.mello@us.army.mil; lxb-1999@163.com; wang@mail.chem.sc.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 239-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861905721 ER PT J AU Li, Y Carroll, RL Gardner, TH AF Li, Yuan Carroll, R. Lloyd Gardner, Todd H. TI COLL 222-Synthesis and characterization of nanoparticle-loaded aerogels SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Li, Yuan] W Virginia Univ, Dept Chem Engn, Morgantown, WV 26506 USA. [Carroll, R. Lloyd] W Virginia Univ, C Eugene Bennett Dept Chem, Morgantown, WV 26506 USA. [Gardner, Todd H.] USA, Dept Energy, Natl Energy Technol Lab, Morgantown, WV 26507 USA. EM yli8@mix.wvu.edu; lloyd.carroll@mail.wvu.edu; todd.gardner@netl.doe.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 222-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861903501 ER PT J AU McGarvey, DJ Creasy, WR Fry, R Durst, HD AF McGarvey, David J. Creasy, William R. Fry, Roderick Durst, H. Dupont TI Comparisons of reactivity of chemical weapons agents to agent simulants SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [McGarvey, David J.] USA, Edgewood Chem Biolg Ctr, Aberdeen Proving Ground, MD 21010 USA. [Creasy, William R.; Fry, Roderick] SAIC, Apg Edgewood, MD 21010 USA. [Durst, H. Dupont] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM david.mcgarvey@us.army.mil; william.creasy@us.army.mil; horatio.d.durst@us.army.mil NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 731-INOR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HZ UT WOS:000207862000613 ER PT J AU Morrissey, KM Nunes, RB Schenning, AM Durst, HD AF Morrissey, Kevin M. Nunes, Robin B. Schenning, Amanda M. Durst, H. Dupont TI ANYL 135-Degradation of the chemical warfare agent soman in potable waters SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Morrissey, Kevin M.; Nunes, Robin B.; Schenning, Amanda M.] Sci Applicat Int Corp, CB Def, Aberdeen Proving Ground, MD 21010 USA. [Durst, H. Dupont] USA, ECBC, Aberdeen Proving Ground, MD 21010 USA. EM kevin.m.morrissey@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 135-ANYL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861901307 ER PT J AU Mosurkal, R Soares, JW Kirby, R Muller, WS Kumar, J AF Mosurkal, Ravi Soares, Jason W. Kirby, Romy Muller, Wayne S. Kumar, Jayant TI POLY 449-Biocatalytic synthesis of novel polyborosiloxane copolymers for flame retardant applications SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Mosurkal, Ravi; Soares, Jason W.; Kirby, Romy; Muller, Wayne S.] USA, Biol Sci & Technol Team, Natick Soldier Res Dev & Engn Ctr, AMSRD NSR WS CB, Natick, MA 01760 USA. [Kumar, Jayant] Univ Massachusetts, Ctr Adv Mat, Dept Phys, Lowell, MA 01854 USA. EM Ravi.Mosurkal@us.army.mil; jason.soares@us.army.mil; Romy.Kirby@us.army.mil; wayne.muller@us.army.mil; Jayant_Kumar@uml.edu RI MOSURKAL, RAVI/P-6981-2015 NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 449-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861906443 ER PT J AU Mrozek, RA Cole, PJ Lenhart, JL Berg, MC Strawhecker, K VanLandingham, M Andzelm, JW Sliozberg, YR Shull, KR Otim, K AF Mrozek, Randy A. Cole, Phillip J. Lenhart, Joseph L. Berg, Michael C. Strawhecker, Kenneth VanLandingham, Mark Andzelm, Jan W. Sliozberg, Yelena R. Shull, Kenneth R. Otim, Katie TI POLY 602-Effect of sol molecular weight on the mechanical properties of elastomeric polysiloxanes SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Mrozek, Randy A.; Lenhart, Joseph L.; Berg, Michael C.; Strawhecker, Kenneth; VanLandingham, Mark; Andzelm, Jan W.; Sliozberg, Yelena R.] USA, Multifunct Mat Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Cole, Phillip J.] Sandia Natl Labs, Albuquerque, NM 87185 USA. [Shull, Kenneth R.; Otim, Katie] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA. EM randy.mrozek@arl.army.mil; pjcole@sandia.gov; joseph.lenhart1@arl.army.mil; mike.berg@arl.army.mil; kenneth.strawhecker@arl.army.mil; mvanlandingham@arl.army.mil; jandzelm@arl.army.mil; yelena.r.sliozberg@arl.army.mil; k-shull@northwestern.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 602-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861906424 ER PT J AU Mrozek, RA Cole, PJ Lenhart, JL AF Mrozek, Randy A. Cole, Phillip J. Lenhart, Joseph L. TI Enhanced melt processing of conductive polymer composites through the addition of a low melting eutectic metal SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Mrozek, Randy A.; Lenhart, Joseph L.] USA, Multifunct Mat Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Cole, Phillip J.] Sandia Natl Labs, Albuquerque, NM 87185 USA. EM randy.mrozek@arl.army.mil; pjcole@sandia.gov; joseph.lenhart1@arl.army.mil NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 544-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861905738 ER PT J AU O'Keefe, B Giomarelli, B Saucedo, C McCray, P Lear, C Olinger, E Palmer, KE Shattock, R McMahon, JB AF O'Keefe, Barry Giomarelli, Barbara Saucedo, Carrie McCray, Paul Lear, Calli Olinger, Eugene Palmer, Kenneth E. Shattock, Robin McMahon, James B. TI CARB 125-Potent antiviral activity of the lectin griffithsin SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [O'Keefe, Barry; Giomarelli, Barbara; Saucedo, Carrie; McMahon, James B.] NCI, Mol Targets Dev Program, NIH, CCR, Frederick, MD 21702 USA. [McCray, Paul] Univ Iowa, Carver Coll Med, Iowa City, IA 52242 USA. [Lear, Calli; Olinger, Eugene] USA, Div Virol, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Palmer, Kenneth E.] Univ Louisville, Dept Pharmacol & Toxicol, James Grahm Brown Canc Res Ctr, Louisville, KY 40202 USA. [Shattock, Robin] St Georges Univ London, Ctr Infect, Div Cellular & Mol Med, London, England. EM okeefe@ncifcrf.gov; kenneth.palmer@louisville.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 125-CARB PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861902037 ER PT J AU Petrova, T Okovytyy, S Gorb, L Leszczynski, J AF Petrova, Tetyana Okovytyy, Sergiy Gorb, Leonid Leszczynski, Jerzy TI Norbornene derivatives: Discovery of diverse reaction pathways depending on substituent's character SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Petrova, Tetyana; Leszczynski, Jerzy] Jackson State Univ, Interdisciplinary Nanotox Ctr, Dept Chem & Biochem, Jackson, MS 39217 USA. [Okovytyy, Sergiy] Dnepropetrovsk Natl Univ, Dept Organ Chem, UA-49625 Dnepropetrovsk, Ukraine. [Gorb, Leonid] USA, Erdc, Vicksburg, MS 39180 USA. EM tetyanka@icnanotox.org; lgorb@ccmsi.us RI Okovytyy, Sergiy/F-9838-2010 OI Okovytyy, Sergiy/0000-0003-4367-1309 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 610-ORGN PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861908456 ER PT J AU Rinderspacher, BC Andzelm, JW Rawlett, AM Dougherty, J Beratan, DN Yang, WT AF Rinderspacher, B. Christopher Andzelm, Jan W. Rawlett, Adam M. Dougherty, Joseph Beratan, David N. Yang, Weitao TI Simultaneous discrete optimization of color and electronic hyperpolarizabilities in a chemical subspace SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Rinderspacher, B. Christopher; Rawlett, Adam M.; Dougherty, Joseph] USA, Res Lab, Div Mat, Multifunct Mat Branch, Aberdeen Proving Ground, MD 21005 USA. [Beratan, David N.; Yang, Weitao] Duke Univ, Dept Chem, Durham, NC 27708 USA. EM jandzelm@arl.army.mil; arawlett@arl.army.mil; david.beratan@duke.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 119-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861904101 ER PT J AU Rinderspacher, BC Andzelm, JW Rawlett, AM Lambeth, RH AF Rinderspacher, B. Christopher Andzelm, Jan W. Rawlett, Adam M. Lambeth, Robert H., III TI Modeling of polymer-attached metal complexes for energy-dissipative materials SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Rinderspacher, B. Christopher; Rawlett, Adam M.; Lambeth, Robert H., III] USA, Res Lab, Div Mat, Multifunct Mat Branch, Aberdeen Proving Ground, MD 21005 USA. EM jandzelm@arl.army.mil; arawlett@arl.army.mil; bob.lambeth@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 112-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861904102 ER PT J AU Rong, C Chu, D AF Rong, Charles Chu, Deryn TI Investigation of metal oxide as hydrogen sulfide sorbent SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Rong, Charles; Chu, Deryn] USA, Res Lab, Adelphi, MD 20783 USA. EM charles.rong@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 143-FUEL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861905073 ER PT J AU Rozvadovsky, S Swanson, JP Jensen, RE Costanzo, PJ AF Rozvadovsky, Svetlana Swanson, John P. Jensen, Robert E. Costanzo, Philip J. TI Tailored polymers for insensitive munitions based upon Diels-Alder chemistry SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Rozvadovsky, Svetlana; Swanson, John P.; Costanzo, Philip J.] Calif Polytech State Univ San Luis Obispo, Dept Chem & Biochem, San Luis Obispo, CA 93405 USA. [Jensen, Robert E.] USA, Div Mat, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM pcostanz@calpoly.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 523-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861905613 ER PT J AU Sliozberg, YR Andzelm, JW Strawhecker, KE Lenhart, JL AF Sliozberg, Yelena R. Andzelm, Jan W. Strawhecker, Kenneth E. Lenhart, Joseph L. TI COLL 146-Predicting structures and mechanical properties of polymeric gels from DPD SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Sliozberg, Yelena R.; Andzelm, Jan W.] USA, Multifunct Mat Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Strawhecker, Kenneth E.; Lenhart, Joseph L.] USA, Weap & Mat Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM yelena.r.sliozberg@arl.army.mil; jandzelm@arl.army.mil; joseph.lenhart1@arl.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 146-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861903067 ER PT J AU Soares, JW North, SH Doherty, LA Slutsky, M Taitt, CR Mello, CM AF Soares, Jason W. North, Stella H. Doherty, Laurel A. Slutsky, Morris Taitt, Chris R. Mello, Charlene M. TI ENVR 43-Antimicrobial peptides for detection of bacterial pathogens SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Soares, Jason W.; Doherty, Laurel A.; Slutsky, Morris; Mello, Charlene M.] US Army Natick Soldier Res, Ctr Dev & Engn, AMSRD NSR WS CB, Biol Sci & Technol Team, Natick, MA 01760 USA. [North, Stella H.; Taitt, Chris R.] USN, Ctr Bio Mol Sci & Engn, Res Lab, Washington, DC 20375 USA. EM jason.soares@us.army.mil; stella.north.ctr@nrl.navy.mil; laurel.doherty@us.army.mil; morris.slutsky@gmail.com; crtaitt@cbmse.nrl.navy.mil; charlene.mello@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 43-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861903702 ER PT J AU Synowczynski, J Andzelm, J Vlachos, DG AF Synowczynski, Jennifer Andzelm, Jan Vlachos, Dionisios G. TI DFT study of the effect of A12O3 support on Pt catalytic activity SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Synowczynski, Jennifer] USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Andzelm, Jan] USA, Div Mat, Multifunct Mat Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Vlachos, Dionisios G.] Univ Delaware, Ctr Catalyt Sci & Technol, Dept Chem Engn, Colburn Lab, Newark, DE 19716 USA. EM jenns@arl.army.mil; jandzelm@arl.army.mil; vlachos@udel.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 231-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861904060 ER PT J AU Szilvay, GR Blenner, M Shur, O Cropek, D Banta, S AF Szilvay, Geza R. Blenner, Mark Shur, Oren Cropek, Donald Banta, Scott TI BIOT 69-The beta roll peptide as a novel allosterically-regulated scaffold for biomolecular recognition SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Szilvay, Geza R.; Blenner, Mark; Shur, Oren; Banta, Scott] Columbia Univ, New York, NY 10027 USA. [Cropek, Donald] USA CERL, Environm Proc Branch, Champaign, IL 61826 USA. EM gs2429@columbia.edu; mab2134@columbia.edu; ocs2004@columbia.edu; Donald.M.Cropek@erdc.usace.army.mil; sbanta@cheme.columbia.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 69-BIOT PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861901662 ER PT J AU Tran, DT Chu, D Oliver, SRJ AF Tran, Dat T. Chu, Deryn Oliver, Scott R. J. TI Synthesis and characterization of cationic inorganic materials and metal-organic frameworks SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Tran, Dat T.; Chu, Deryn] USA, Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. [Oliver, Scott R. J.] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA. EM dat.tran1@arl.army.mil; dchu@arl.army.mil; soliver@chemistry.ucsc.edu NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 89-INOR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HZ UT WOS:000207862000166 ER PT J AU Wagner, GW AF Wagner, George W. TI All-weather, hydrogen peroxide-based decontamination of CBRN contaminants SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Wagner, George W.] USA, Edgewood Chem Biol Ctr, Attn AMSRD ECB RT PF, Aberdeen Proving Ground, MD 21010 USA. EM george.wagner@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 398-INOR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HZ UT WOS:000207862000120 ER PT J AU Wick, CH Jabbour, RE Deshpande, SV Stanford, MF Zulich, AW AF Wick, Charles H. Jabbour, Rabih E. Deshpande, Samir V. Stanford, Michael F. Zulich, Alan W. TI ANYL 284-LC mass spectrometry proteomic-based approach for bacterial identification and classification using blinded bacterial samples SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Wick, Charles H.; Stanford, Michael F.; Zulich, Alan W.] USA, Edgewood Chem Biol Ctr, Res & Technol Directorate, ATTN AMSRD ECB RT DD, Aberdeen Proving Ground, MD 21010 USA. [Jabbour, Rabih E.] SAIC, Aberdeen Proving Ground, MD 21010 USA. [Deshpande, Samir V.] Sci & Technol Corp, Aberdeen Proving Ground, MD 21010 USA. EM charles.h.wick@us.army.mil NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 284-ANYL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861901049 ER PT J AU Williams, DJ Creasy, WR McGarvey, DJ Fry, RA Bevilacqua, VLH Durst, HD AF Williams, Daniel J. Creasy, William R. McGarvey, David J. Fry, Roderick A. Bevilacqua, Vicky L. H. Durst, H. Dupont TI Greener methods for the destruction of phosphorus based chemical warfare agents SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Williams, Daniel J.] Kennesaw State Univ, Dept Chem & Biochem, Kennesaw, GA 30144 USA. [Creasy, William R.; Fry, Roderick A.] SAIC, Apg Edgewood, MD 21010 USA. [Bevilacqua, Vicky L. H.] US Army Edgewood Chem Biol Ctr, Point Detect Branch, Aberdeen Proving Ground, MD 21010 USA. EM dwilliam@kennesaw.edu; william.creasy@us.army.mil; david.mcgarvey@us.army.mil; vicky.bevilacqua@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 399-INOR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HZ UT WOS:000207862000024 ER PT J AU Yeh, IC Lee, MS Olson, M AF Yeh, In-Chul Lee, Michael S. Olson, Mark TI Protein heat capacity calculated from replica-exchange molecular dynamics simulations with different implicit solvent models SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Yeh, In-Chul] USA, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. [Lee, Michael S.; Olson, Mark] USAMRIID, Dept Cell Biol & Biochem, Ft Detrick, MD 21702 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 159-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861904083 ER PT J AU Zander, NE Orlicki, JA Rawlett, AM AF Zander, Nicole E. Orlicki, Joshua A. Rawlett, Adam M. TI POLY 343-Thermal and FTIR characterization of poly (4-vinylpyridine) crosslinked with metal salts SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Zander, Nicole E.; Orlicki, Joshua A.; Rawlett, Adam M.] USA, Res Lab, Div Mat, Multifunct Mat Branch, Aberdeen Proving Ground, MD 21005 USA. EM jorlicki@arl.army.mil; arawlett@arl.army.mil NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 343-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861906087 ER PT J AU Samanta, U Kirby, SD Srinivasan, P Cerasoli, DM Bahnson, BJ AF Samanta, Uttamkumar Kirby, Stephen D. Srinivasan, Prabhavathi Cerasoli, Douglas M. Bahnson, Brian J. TI Crystal structures of human group-VIIA phospholipase A2 inhibited by organophosphorus nerve agents exhibit non-aged complexes SO BIOCHEMICAL PHARMACOLOGY LA English DT Article DE Phospholipase A2; Lp-PLA2; PAF-AH; Organophosphate; Nerve agent ID ACTIVATING-FACTOR ACETYLHYDROLASE; ANHYDRIDE HYDROLASE ACTIVITY; HUMAN BUTYRYLCHOLINESTERASE; LIPOPROTEIN BINDING; SERUM PARAOXONASE; REACTION-PRODUCTS; CATALYTIC TRIAD; ACETYLCHOLINESTERASE; SOMAN; A(2) AB The enzyme group-VIIA phospholipase A2 (gVIIA-PLA2) is bound to lipoproteins in human blood and hydrolyzes the ester bond at the sn-2 position of phospholipid substrates with a short sn-2 chain. The enzyme belongs to a serine hydrolase superfamily of enzymes, which react with organophosphorus (OP) nerve agents. OPs ultimately exert their toxicity by inhibiting human acetycholinesterase at nerve synapses, but may additionally have detrimental effects through inhibition of other serine hydrolases. We have solved the crystal structures of gVIIA-PLA2 following inhibition with the OPs diisopropylfluorophosphate, satin, soman and tabun. The satin and soman complexes displayed a racemic Mix Of PR and P(s) stereoisomers at the P-chiral center. The tabun complex displayed only the PR stereoisomer in the crystal. In all cases, the crystal structures contained intact OP adducts that had not aged. Aging refers to a secondary process OP complexes can go through, which dealkylates the nerve agent adduct and results in a form that is highly resistant to either spontaneous or oxime-mediated reactivation. Non-aged OP complexes of the enzyme were corroborated by trypsin digest and matrix-assisted laser desorption ionization mass spectrometry of OP-enzyme complexes. The lack of stereoselectivity of sarin reaction was confirmed by gas chromatography/mass spectrometry using a chiral column to separate and quantitate the unbound stereoisomers of sarin following incubation with enzyme. The structural details and characterization of nascent reactivity of several toxic nerve agents is discussed with a long-term goal of developing gVIIA-PLA2 as a catalytic bioscavenger of OP nerve agents. (C) 2009 Elsevier Inc. All rights reserved. C1 [Samanta, Uttamkumar; Kirby, Stephen D.; Srinivasan, Prabhavathi; Bahnson, Brian J.] Univ Delaware, Dept Chem & Biochem, Newark, DE 19716 USA. [Kirby, Stephen D.; Cerasoli, Douglas M.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Bahnson, BJ (reprint author), Univ Delaware, Dept Chem & Biochem, 312 Drake Hall, Newark, DE 19716 USA. EM bahnson@udel.edu FU Advance Photon Source at the Argonne National Laboratory [191D, 241D] FX We thank ICOS Corp. for supplying us with the protein PAFase. We thank Dr. James Dillman and Ms. Lisa Bottalico for obtaining MALDI-MS data and Mr. Rick Smith for helping to complete the GC/MS analysis at the USAMRICD. We also thank the support staff of 191D and 241D beam lines of Advance Photon Source at the Argonne National Laboratory for assistance during X-ray diffraction data collection. NR 40 TC 11 Z9 12 U1 0 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0006-2952 J9 BIOCHEM PHARMACOL JI Biochem. Pharmacol. PD AUG 15 PY 2009 VL 78 IS 4 BP 420 EP 429 DI 10.1016/j.bcp.2009.04.018 PG 10 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 464TG UT WOS:000267529200013 PM 19394314 ER PT J AU Gent, DB Wani, AH Davis, JL Alshawabkah, A AF Gent, David B. Wani, Altaf H. Davis, Jeffrey L. Alshawabkah, Akram TI Electrolytic Redox and Electrochemical Generated Alkaline Hydrolysis of Hexahydro-1,3,5-trinitro-1,3,5 triazine (RDX) in Sand Columns SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID BIODEGRADATION COLUMN; CONTAMINATED WATER; ANAEROBIC SLUDGE; EXPLOSIVES RDX; DEGRADATION; TRANSFORMATION; REMEDIATION; 1,3,5-TRIAZA-1,3,5-TRINITROCYCLOHEXANE; GROUNDWATER; INCUBATION AB Sand-packed horizontal flow columns (5 cm i.d. x 65 cm) were used in laboratory experiments to simulate in Situ electrolytic and alkaline hybrid treatment zone for aqueous phase decomposition of RDX. An upgradient cathode and downgradient anode, spaced 35 cm apart were used to create alkaline reducing conditions followed by oxic, acidic conditions to degrade RDX by combination of alkaline hydrolysis and direct electrolysis. A preliminary experiment (25 mg/L RDX influent) with seepage velocity of 30.5 cm/day and current density of 9.9 A/m(2) was used to determine the treatment feasibility and the aqueous products of RDX decomposition. Three additional column experiments (0.5mg/LRDX influent) under the same conditions as the preliminary column were used to observe the treatment process repeatability and the alkaline treatment zone development The results demonstrated approximately 95% decomposition of RDX in the column with an applied current density of 9.9 A/m(2). Aqueous end-products formate, nitrite, and nitrate were detected in the effluent Approximately 75% of the RDX was destroyed near the cathode, presumably by electrolysis, with 23% decomposed downstream of the cathode by alkaline hydrolysis. The preliminary column pseudo first order alkaline hydrolysis rate coefficient of 10.7 x 10(-3) min(-1) was used to estimate a treatment zone length less than 100 cm for RDX treatment below the EPA drinking water lifetime health advisory of 0.002 mg/L. C1 [Alshawabkah, Akram] Northeastern Univ, Dept Civil & Environm Engn, Boston, MA 02115 USA. [Gent, David B.; Davis, Jeffrey L.] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Wani, Altaf H.] ERM, Houston, TX 77084 USA. RP Alshawabkah, A (reprint author), Northeastern Univ, Dept Civil & Environm Engn, 360 Huntington Ave, Boston, MA 02115 USA. EM aalsha@coe.neu.edu NR 29 TC 17 Z9 18 U1 1 U2 16 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD AUG 15 PY 2009 VL 43 IS 16 BP 6301 EP 6307 DI 10.1021/es803567s PG 7 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 482RZ UT WOS:000268907700034 PM 19746729 ER PT J AU Bourke, MC Ewing, RC Finnegan, D McGowan, HA AF Bourke, Mary C. Ewing, Ryan C. Finnegan, David McGowan, Hamish A. TI Sand dune movement in the Victoria Valley, Antarctica SO GEOMORPHOLOGY LA English DT Article DE Antarctica; Dune; Niveo-aeolian; Migration ID BARCHAN DUNES; SOUTHERN PERU; SPATIALLY DIVERSE; EOLIAN SEDIMENT; IMPERIAL VALLEY; FIELD PATTERNS; WIND; CALIFORNIA; TRANSPORT; DEPOSITS AB We use vertical aerial photographs and LiDAR topographic survey data to estimate dune migration rates in the Victoria Valley dunefield, Antarctica, between 1961 and 2001. Results confirm that the dunes migrated an average of 1.5 m/year. These values are consistent with other estimates of dune migration from cold climate deserts and are significantly lower than estimates from warm deserts. Dune migration rates are retarded by the presence of entrained ice, soil moisture and a reversing wind regime. Dune absorption, merging and limb extension are apparent from the time-series images and account for significant changes in dune form and the field-scale dune pattern. Dune-field pattern analysis shows an overall increase in dune-field organization with an increase in mean dune spacing and a reduction in total crest length and defect density. These data suggest that dunes in other cold desert environments on Earth, Mars or Titan, that may also have interbedded frozen laminae, still have the potential to migrate and organize, albeit at lower rates than dunes in warm deserts. (C) 2009 Elsevier B.V. All rights reserved. C1 [Bourke, Mary C.] Planetary Sci Inst, Tucson, AZ USA. [Bourke, Mary C.] Univ Oxford, Sch Geog, OUCE, Oxford OX1 3QY, England. [Ewing, Ryan C.] Univ Texas Austin, Jackson Sch Geosci, Dept Geol Sci, Austin, TX 78712 USA. [Finnegan, David] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [McGowan, Hamish A.] Univ Queensland, Sch Geog Planning & Architecture, St Lucia, Qld 4072, Australia. RP Bourke, MC (reprint author), Planetary Sci Inst, 1700 E Ft Lowell,106, Tucson, AZ USA. EM mbourke@psi.edu RI Bourke, Mary/I-4387-2012 OI Bourke, Mary/0000-0002-0424-0322 FU NASA MFRP [NNX08AP43G] FX Special thanks are given to Bea Muller, Kai Wunnemann and Grusche Junker for their assistance with translating Miotke (1985). Data for Fig. 3 were from the Long-Term Ecological Research McMurdo Dry Valleys Program, and Joh Spiers is thanked for producing the figure. This is PSI contribution 441. Funding for this project is from NASA MFRP Grant # NNX08AP43G. NR 68 TC 28 Z9 32 U1 3 U2 22 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-555X J9 GEOMORPHOLOGY JI Geomorphology PD AUG 15 PY 2009 VL 109 IS 3-4 BP 148 EP 160 DI 10.1016/j.geomorph.2009.02.028 PG 13 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA 468DO UT WOS:000267794800007 ER PT J AU Pomeroy, JW Marks, D Link, T Ellis, C Hardy, J Rowlands, A Granger, R AF Pomeroy, John W. Marks, Danny Link, Tim Ellis, Chad Hardy, Janet Rowlands, Aled Granger, Raoul TI The impact of coniferous forest temperature on incoming longwave radiation to melting snow SO HYDROLOGICAL PROCESSES LA English DT Article DE snowmelt; longwave radiation; forest temperature; shortwave radiation; transmissivity; pine forest; rocky mountains; CLPX ID BOREAL FOREST; ENERGY-BALANCE; SHORTWAVE IRRADIANCE; SOLAR-RADIATION; PINE CANOPY; MODEL; SENSITIVITY; ABLATION; TRANSMISSION; SIMULATION AB Measurements were conducted in coniferous forests of differing density, insolation and latitude to test whether air temperatures are suitable surrogates for canopy temperature in estimating sub-canopy longwave irradiance to snow. Air temperature generally was a good representation of canopy radiative temperature under conditions of low insolation. However during high insolation, needle and branch temperatures were well estimated by air temperature only in relatively dense canopies and exceeded air temperatures elsewhere. Tree trunks exceeded air temperatures in all canopies during high insolation, with the relatively hottest trunks associated with direct interception of sunlight, sparse canopy cover and dead trees. The exitance of longwave radiation from these relatively warm canopies exceeded that calculated assuming canopy temperature was equal to air temperature. This enhancement was strongly related to the extinction of shortwave radiation by the canopy. Estimates of sub-canopy Ion-wave irradiance using either two-energy source or two thermal regime approaches to evaluate the contribution of canopy longwave exitance performed better than did estimates that used only air temperature and sky view. However, there was little evidence that such corrections are necessary under cloudy or low solar insolation conditions. The longwave enhancement effect due to shortwave extinction was important to sub-canopy longwave irradiance to snow during clear, sunlit conditions. Longwave enhancement increased with increasing solar elevation angle and decreasing air temperature. Its relative importance to longwave irradiance to snow was insensitive to canopy density. As errors from ignoring enhanced longwave contributions from the canopy accumulate over the winter season, it is important for snow energy balance computations to include the enhancement in order to better calculate snow internal energy and therefore the timing and magnitude of snowmelt and sublimation. Copyrigght (C) 2009 John Wiley & Soils, Ltd. C1 [Pomeroy, John W.; Ellis, Chad] Univ Saskatchewan, Ctr Hydrol, Saskatoon, SK S7N 5C8, Canada. [Marks, Danny] USDA ARS, NW Watershed Res Ctr, Boise, ID 83712 USA. [Link, Tim] Univ Idaho, Coll Forest Resources, Moscow, ID 83843 USA. [Hardy, Janet] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Rowlands, Aled] Aberystwyth Univ, Inst Geog & Earth Sci, Aberystwyth, Dyfed, Wales. [Granger, Raoul] Environm Canada, Saskatoon, SK S7N 3H5, Canada. RP Pomeroy, JW (reprint author), Univ Saskatchewan, Ctr Hydrol, Saskatoon, SK S7N 5C8, Canada. EM john.pomeroy@usask.ca RI Link, Timothy/G-5556-2012; Pomeroy, John/A-8589-2013 OI Pomeroy, John/0000-0002-4782-7457 NR 33 TC 69 Z9 70 U1 2 U2 31 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 0885-6087 J9 HYDROL PROCESS JI Hydrol. Process. PD AUG 15 PY 2009 VL 23 IS 17 BP 2513 EP 2525 DI 10.1002/hyp.7325 PG 13 WC Water Resources SC Water Resources GA 485EG UT WOS:000269103200010 ER PT J AU Amoyaw, P Ingram, C Hsu, FL Bu, XR AF Amoyaw, Prince Ingram, Conrad Hsu, Fu-Lian Bu, Xiu R. TI Poly[4-(4-vinylbenzyloxy)-2-hydroxylbenzaldehyde] for Rapid Removal of Low Concentrations of Pb(II) SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article DE salicylaldehyde; chelating polymer; heavy metal removal; lead complex ID ADSORPTION; WATER; LEAD; MERCURY; METALS; BEADS; IONS AB Poly (4-(4-vinylbenzyloxy)-2-hydroxylbenzaldehyde] was evaluated for removing tow concentrations of lead(II) in ppb levels from aqueous media. The effects of the pH condition and the initial lead concentrations on removal were examined. It was found that the metal absorption is best described with the Langmuir model. The R(L) values obtained between 0.01 and 0.23 indicate that favorable absorption occurs in the studied concentration ranges. The kinetic study revealed that the metal removal proceeds at a very fast pace-less than 30 s-to reach the maximum capacity. The data fit the description of pseudo-second-order rate. The dynamic column study for real-time practical absorption also was investigated. (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 113:2096-2102, 2009 C1 [Amoyaw, Prince; Ingram, Conrad; Bu, Xiu R.] Clark Atlanta Univ, Dept Chem, Atlanta, GA 30314 USA. [Amoyaw, Prince; Ingram, Conrad; Bu, Xiu R.] Clark Atlanta Univ, NASA, Ctr High Performance Polymers & Composites, Atlanta, GA 30314 USA. [Hsu, Fu-Lian] USA, Edgewood Chem & Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Bu, XR (reprint author), Clark Atlanta Univ, Dept Chem, Atlanta, GA 30314 USA. EM xbu@cau.edu FU DOE [DE-FG52-05NA27040, De-FC02-02EW15254]; NSF [HRD-0630456] FX Contract grant sponsor: DOE; contract grant numbers: DE-FG52-05NA27040, De-FC02-02EW15254. Contract grant sponsor: NSF; contract grant number: HRD-0630456. NR 31 TC 3 Z9 5 U1 0 U2 2 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0021-8995 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD AUG 15 PY 2009 VL 113 IS 4 BP 2096 EP 2102 DI 10.1002/app.30162 PG 7 WC Polymer Science SC Polymer Science GA 457PU UT WOS:000266945300006 ER PT J AU Qasim, M Gorb, L Magers, D Honea, P Leszczynski, J Moore, B Taylor, L Middleton, M AF Qasim, Mohammad Gorb, Leonid Magers, David Honea, P. Leszczynski, J. Moore, Brett Taylor, Lyssa Middleton, Matthew TI Structure and reactivity of TNT and related species: Application of spectroscopic approaches and quantum-chemical approximations toward understanding transformation mechanisms SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE Alkali hydrolysis; Free radicals; Nitroaromatics; Oxidative/reductive reactions; Photolysis ID CATFISH ICTALURUS-PUNCTATUS; TRINITROTOLUENE TNT; AQUATIC ORGANISMS; 2,4,6-TRINITROTOLUENE; SOIL; BIOCONCENTRATION; ACCUMULATION AB This paper presents our latest findings regarding the structure and reactivity of the nitroaromatics, TNT and selected derivatives, within their environmental context. We also demonstrate the useful and proactive role of combined computational chemistry and spectroscopy tools in studying competing transformation mechanisms, particularly those with toxic potential. TNT and selected derivatives were reacted via alkaline hydrolysis as well as via free radical initiators through monochromatic irradiation and through Fenton reactions in complex competing transformation mechanisms. Only alkaline hydrolysis produced consistent and effective transformation intermediate and final products in this research. However, irradiation of the product generated by alkaline hydrolysis at 450 nm (wavelength of maximum absorption) caused complete disappearance of the spectra. Published by Elsevier B.V. C1 [Qasim, Mohammad; Leszczynski, J.; Moore, Brett; Taylor, Lyssa; Middleton, Matthew] USACE ERDC EL, Vicksburg, MS 39180 USA. [Gorb, Leonid] SpecPro, Vicksburg, MS 39180 USA. [Magers, David; Moore, Brett; Taylor, Lyssa] Mississippi Coll, Clinton, MS 39058 USA. [Honea, P.] Univ Mississippi, Sch Med, Jackson, MS 39216 USA. [Leszczynski, J.] Jackson State Univ, Computat Ctr Mol Struct & Interact, Jackson, MS 39217 USA. [Middleton, Matthew] Mississippi State Univ, Starkville, MS 39762 USA. RP Qasim, M (reprint author), USACE ERDC EL, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM qasimm@erdc.usace.army.mil NR 32 TC 17 Z9 17 U1 1 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD AUG 15 PY 2009 VL 167 IS 1-3 BP 154 EP 163 DI 10.1016/j.jhazmat.2008.12.105 PG 10 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 461KX UT WOS:000267267000021 PM 19200649 ER PT J AU Awandare, GA Martinson, JJ Were, T Ouma, C Davenport, GC Ong'echa, JM Wang, WK Leng, L Ferrell, RE Bucala, R Perkins, DJ AF Awandare, Gordon A. Martinson, Jeremy J. Were, Tom Ouma, Collins Davenport, Gregory C. Ong'echa, John M. Wang, Wenkui Leng, Lin Ferrell, Robert E. Bucala, Richard Perkins, Douglas J. TI MIF (Macrophage Migration Inhibitory Factor) Promoter Polymorphisms and Susceptibility to Severe Malarial Anemia SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID PLASMODIUM-FALCIPARUM MALARIA; JUVENILE IDIOPATHIC ARTHRITIS; HIGH-DENSITY PARASITEMIA; RHEUMATOID-ARTHRITIS; FUNCTIONAL-CHANGES; DISEASE SEVERITY; YOUNG-CHILDREN; FACTOR GENE; TRANSMISSION; INFANTS AB Background. Severe malarial anemia (SMA) resulting from Plasmodium falciparum infection is one of the leading causes of childhood mortality in sub-Saharan Africa. The innate immune mediator macrophage migration inhibitory factor (MIF) plays a critical role in the pathogenesis of SMA. Methods. To investigate the influence of MIF genetic variation on susceptibility to SMA, haplotypes of the MIF -173G/C and -794CATT(5-8) polymorphisms were examined in a cohort of Kenyan children. Results. A statistically significant relationship between increasing frequencies of longer CATT repeats at -794 and increasing severity of malarial anemia was observed. In addition, there was a strong association between lower MIF concentrations and longer CATT repeats. Multivariate logistic regression analyses demonstrated that the 6G haplotype (ie, MIF -794CATT(6)/-173G) was associated with protection against SMA, whereas carriers of the 7C or 8C haplotype had increased risk of developing SMA. Furthermore, carriers of the 7C or 8C haplotype had reduced plasma MIF levels during acute disease. Conclusions. The findings demonstrate that variation in the MIF promoter influences susceptibility to SMA and peripheral MIF production. However, the MIF -173 and -794 polymorphisms appear to have both independent and interactive effects on different measures of disease severity, suggesting that MIF plays a complex role in malarial pathogenesis. C1 [Perkins, Douglas J.] Univ New Mexico, Div Infect Dis, Sch Med, Albuquerque, NM 87131 USA. [Ouma, Collins] Maseno Univ, Dept Biomed Sci & Technol, Maseno, Kenya. [Were, Tom; Ouma, Collins; Ong'echa, John M.; Perkins, Douglas J.] Univ New Mexico, Kenya Med Res Inst, Labs Parasit & Viral Dis, Ctr Global Hlth Res, Kisumu, Kenya. [Ferrell, Robert E.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Human Genet, Pittsburgh, PA 15261 USA. [Awandare, Gordon A.; Martinson, Jeremy J.; Davenport, Gregory C.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Infect Dis & Microbiol, Pittsburgh, PA 15261 USA. [Wang, Wenkui; Leng, Lin; Bucala, Richard] Yale Univ, Sch Med, Dept Med, New Haven, CT 06510 USA. [Awandare, Gordon A.] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. RP Perkins, DJ (reprint author), Univ New Mexico, Div Infect Dis, Sch Med, MSC10-5550,1 Univ New Mexico, Albuquerque, NM 87131 USA. EM DPerkins@salud.unm.edu OI Martinson, Jeremy/0000-0003-4673-7238; Awandare, Gordon/0000-0002-8793-3641 FU National Institutes of Health [2 R01AI51305]; Fogarty International Center [1 D43TW05884, AI51306] FX Financial support: National Institutes of Health ( grant 2 R01AI51305 to D.J.P., Fogarty International Center Training Grant 1 D43TW05884 to D.J.P., and grant AI51306 to R. B.). NR 47 TC 30 Z9 30 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD AUG 15 PY 2009 VL 200 IS 4 BP 629 EP 637 DI 10.1086/600894 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 470VN UT WOS:000268009700021 PM 19591577 ER PT J AU Tarselli, MA Zuccarello, JL Lee, SJ Gagne, MR AF Tarselli, Michael A. Zuccarello, J. Lucas Lee, Stephen J. Gagne, Michel R. TI Gold(I)-Catalyzed Cascade Cyclization of Allenyl Epoxides SO ORGANIC LETTERS LA English DT Article ID GOLD-CATALYZED CYCLOISOMERIZATION; INTERMOLECULAR HYDROALKOXYLATION; ASYMMETRIC EPOXIDATION; POLYENE CYCLIZATION; OPENING CASCADES; ALCOHOLS; WATER; OXACYCLIZATIONS; GLABRESCOL; MONENSIN AB Cationic gold(I) phosphite catalysts activate allenes for epoxide cascade reactions. The system is tolerant of numerous functional groups (sulfones, esters, ethers, sulfonamides) and proceeds at room temperature in dichloromethane. The cyclization pathway is sensitive to the substitution pattern of the epoxide and the backbone structure of the A-ring. It is capable of producing medium-ring ethers, fused 6-5 bicyclic, and linked pyran-furan structures. The resulting cycloisomers are reminiscent of structures found in numerous polyether natural products. C1 [Lee, Stephen J.] Univ N Carolina, Caudill Labs, Chapel Hill, NC 27599 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Lee, SJ (reprint author), Univ N Carolina, Caudill Labs, Chapel Hill, NC 27599 USA. EM Stephen.Lee2@us.army.mil; mgagne@unc.edu OI Tarselli, Michael A./0000-0003-1285-3134 FU NIH Institutes of General Medicine [GM-60578]; National Research Council; ARO FX We thank Prof. Michael Crimmins and Prof. Jeff Johnson (UNC) for helpful discussions. We acknowledge NIH Institutes of General Medicine (GM-60578) for financial support. J.L.Z. thanks the National Research Council for a Postdoctoral Fellowship, and S.J.L. thanks the ARO for Staff Research Funding. NR 50 TC 26 Z9 26 U1 1 U2 10 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1523-7060 J9 ORG LETT JI Org. Lett. PD AUG 6 PY 2009 VL 11 IS 15 BP 3490 EP 3492 DI 10.1021/ol901391s PG 3 WC Chemistry, Organic SC Chemistry GA 476XK UT WOS:000268479900083 PM 19588972 ER PT J AU Pittman, PR Liu, CT Cannon, TL Mangiafico, JA Gibbs, PH AF Pittman, Phillip R. Liu, Ching-Tong Cannon, Timothy L. Mangiafico, Joseph A. Gibbs, Paul H. TI Immune interference after sequential alphavirus vaccine vaccinations SO VACCINE LA English DT Article DE Alphavirus; Eastern equine encephalitis; Western equine encephalitis; Venezuelan equine encephalitis ID VENEZUELAN EQUINE ENCEPHALOMYELITIS; EMBRYO CELL CULTURE; CROSS-PROTECTION; VIRUS; ENCEPHALITIS; EASTERN; ANTIBODIES AB We compared the effect of order of administration of investigational alphavirus vaccines on neutralizing antibody response. Volunteers who received the inactivated eastern and western equine encephalitis (EEE and WEE) vaccines before live attenuated Venezuelan (VEE) vaccine had significantly lower rates of antibody response than those receiving VEE vaccine before EEE and WEE vaccines (66.7% vs. 80.6%; p = 0.026). The odds of having a VEE antibody non-response among those initially receiving EEE and WEE vaccines, adjusted for gender, were significant (odds ratio [OR] = 2.20; 95% CI = 1.2-4.1 [p = 0.0145]) as were the odds of non-response among females adjusted for group (OR = 1.81; 95% CI = 1.2-2.7 [p = 0.0037]). Antibody interference and gender effect have major implications for vaccine strategy among those receiving multiple alphavirus vaccines and those developing next generation vaccines for these threats. (C) 2009 Published by Elsevier Ltd. C1 [Pittman, Phillip R.; Liu, Ching-Tong; Mangiafico, Joseph A.; Gibbs, Paul H.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Cannon, Timothy L.] Directorate Informat Management, Informat Support Div, Ft Detrick, MD 21702 USA. RP Pittman, PR (reprint author), USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM phillip.pittman@amedd.army.mil FU U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD FX The authors thank Drs. Kelly McKee and Ellen Boudreau for their critiques of the manuscript. Special acknowledgement is given to Alberta Blake, RN, who administered the vaccines in the Special Immunizations Clinic, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, between 1987 and 1999. NR 24 TC 8 Z9 8 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD AUG 6 PY 2009 VL 27 IS 36 BP 4879 EP 4882 DI 10.1016/j.vaccine.2009.02.090 PG 4 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 484UA UT WOS:000269071800003 PM 19576665 ER PT J AU Wei, HH Lu, XCM Shear, DA Waghray, A Yao, CP Tortella, FC Dave, JR AF Wei, Hans H. Lu, Xi-Chun M. Shear, Deborah A. Waghray, Anu Yao, Changping Tortella, Frank C. Dave, Jitendra R. TI NNZ-2566 treatment inhibits neuroinflammation and pro-inflammatory cytokine expression induced by experimental penetrating ballistic-like brain injury in rats SO JOURNAL OF NEUROINFLAMMATION LA English DT Article ID GROWTH-FACTOR-I; GLYCINE-PROLINE-GLUTAMATE; PIGMENT EPITHELIAL-CELLS; N-TERMINAL TRIPEPTIDE; NECROSIS-FACTOR-ALPHA; CENTRAL-NERVOUS-SYSTEM; CLOSED-HEAD INJURY; GENE-EXPRESSION; IGF-I; NEUTROPHIL INFILTRATION AB Background: Inflammatory cytokines play a crucial role in the pathophysiology of traumatic brain injury (TBI), exerting either deleterious effects on the progression of tissue damage or beneficial roles during recovery and repair. NNZ-2566, a synthetic analogue of the neuroprotective tripeptide Glypromate (R), has been shown to be neuroprotective in animal models of brain injury. The goal of this study was to determine the effects of NNZ-2566 on inflammatory cytokine expression and neuroinflammation induced by penetrating ballistic-like brain injury (PBBI) in rats. Methods: NNZ-2566 or vehicle (saline) was administered intravenously as a bolus injection (10 mg/kg) at 30 min post-injury, immediately followed by a continuous infusion of NNZ-2566 (3 mg/kg/h), or equal volume of vehicle, for various durations. Inflammatory cytokine gene expression from the brain tissue of rats exposed to PBBI was evaluated using microarray, quantitative real time PCR (QRT-PCR), and enzyme-linked immunosorbent assay (ELISA) array. Histopathology of the injured brains was examined using hematoxylin and eosin (H&E) and immunocytochemistry of inflammatory cytokine IL-1 beta. Results: NNZ-2566 treatment significantly reduced injury-mediated up-regulation of IL-1 beta, TNF-alpha, E-selectin and IL-6 mRNA during the acute injury phase. ELISA cytokine array showed that NZ-2566 treatment significantly reduced levels of the pro-inflammatory cytokines IL-1 beta, TNF-alpha and IFN-gamma in the injured brain, but did not affect anti-inflammatory cytokine IL- 6 levels. Conclusion: Collectively, these results suggest that the neuroprotective effects of NNZ-2566 may, in part, be functionally attributed to the compound's ability to modulate expression of multiple neuroinflammatory mediators in the injured brain. C1 [Wei, Hans H.; Lu, Xi-Chun M.; Shear, Deborah A.; Waghray, Anu; Yao, Changping; Tortella, Frank C.; Dave, Jitendra R.] Walter Reed Army Inst Res, Dept Appl Neurobiol, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Wei, HH (reprint author), Walter Reed Army Inst Res, Dept Appl Neurobiol, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. EM hans.wei@us.army.mil; may.lu@amedd.army.mil; deborah.shear@amedd.army.mil; anu.waghray@amedd.army.mi; changping.yao@amedd.army.mil; frank.tortella@amedd.army.mil; jit.dave@amedd.army.mil RI Shear, Deborah/B-3607-2011 FU Neuren Pharmaceuticals Ltd. [W81XWH-05-0074] FX We would like to thank SPC. Monika Torres and SPC. Katie Phillips for their excellent technical assistance and Ms. Christine Gallo for her help in manuscript preparation. These studies were supported in part by a cooperative research and development agreement with Neuren Pharmaceuticals Ltd. (W81XWH-05-0074). NR 64 TC 34 Z9 34 U1 1 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-2094 J9 J NEUROINFLAMM JI J. Neuroinflamm. PD AUG 5 PY 2009 VL 6 AR 19 DI 10.1186/1742-2094-6-19 PG 10 WC Immunology; Neurosciences SC Immunology; Neurosciences & Neurology GA 495DB UT WOS:000269869000001 PM 19656406 ER PT J AU VanBuskirk, KM O'Neill, MT De la Vega, P Maier, AG Krzych, U Williams, J Dowler, MG Sacci, JB Kangwanrangsan, N Tsuboi, T Kneteman, NM Heppner, DG Murdock, BA Mikolajczak, SA Aly, ASI Cowman, AF Kappe, SHI AF VanBuskirk, Kelley M. O'Neill, Matthew T. De la Vega, Patricia Maier, Alexander G. Krzych, Urszula Williams, Jack Dowler, Megan G. Sacci, John B., Jr. Kangwanrangsan, Niwat Tsuboi, Takafumi Kneteman, Norman M. Heppner, Donald G., Jr. Murdock, Brant A. Mikolajczak, Sebastian A. Aly, Ahmed S. I. Cowman, Alan F. Kappe, Stefan H. I. TI Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE genetically attenuated parasites; malaria vaccine; P36; P52; sporozoite ID CD8(+) T-CELLS; MALARIA PARASITES; PROTECTIVE IMMUNITY; IRRADIATED SPOROZOITES; STERILE PROTECTION; STAGE DEVELOPMENT; BERGHEI; INFECTION; PROTEINS; TRANSFORMATION AB Falciparum malaria is initiated when Anopheles mosquitoes transmit the Plasmodium sporozoite stage during a blood meal. Irradiated sporozoites confer sterile protection against subsequent malaria infection in animal models and humans. This level of protection is unmatched by current recombinant malaria vaccines. However, the live-attenuated vaccine approach faces formidable obstacles, including development of accurate, reproducible attenuation techniques. We tested whether Plasmodium falciparum could be attenuated at the early liver stage by genetic engineering. The P. falciparum genetically attenuated parasites (GAPs) harbor individual deletions or simultaneous deletions of the sporozoite-expressed genes P52 and P36. Gene deletions were done by double-cross-over recombination to avoid genetic reversion of the knockout parasites. The gene deletions did not affect parasite replication throughout the erythrocytic cycle, gametocyte production, mosquito infections, and sporozoite production rates. However, the deletions caused parasite developmental arrest during hepatocyte infection. The double-gene deletion line exhibited a more severe intrahepatocytic growth defect compared with the single-gene deletion lines, and it did not persist. This defect was assessed in an in vitro liver-stage growth assay and in a chimeric mouse model harboring human hepatocytes. The strong phenotype of the double knockout GAP justifies its human testing as a whole-organism vaccine candidate using the established sporozoite challenge model. GAPs might provide a safe and reproducible platform to develop an efficacious whole-cell malaria vaccine that prevents infection at the preerythrocytic stage. C1 [O'Neill, Matthew T.; Maier, Alexander G.; Cowman, Alan F.] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia. [VanBuskirk, Kelley M.; Murdock, Brant A.; Mikolajczak, Sebastian A.; Aly, Ahmed S. I.; Kappe, Stefan H. I.] Seattle Biomed Res Inst, Seattle, WA 98109 USA. [De la Vega, Patricia; Krzych, Urszula; Williams, Jack; Dowler, Megan G.; Heppner, Donald G., Jr.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Sacci, John B., Jr.] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA. [Kangwanrangsan, Niwat; Tsuboi, Takafumi] Ehime Univ, Dept Mol Parasitol, Grad Sch Med, Matsuyama, Ehime 7910295, Japan. [Kangwanrangsan, Niwat; Tsuboi, Takafumi] Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime 7910295, Japan. [Kneteman, Norman M.] Univ Alberta, Dept Surg, Sect Hepatobiliary Pancreat & Transplant Surg, Edmonton, AB T6H 2S2, Canada. [Kappe, Stefan H. I.] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA. RP Cowman, AF (reprint author), Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia. EM cowman@wehi.edu.au; stefan.kappe@sbri.org RI Cowman, Alan/C-7642-2013; Maier, Alex/A-6499-2009; OI Cowman, Alan/0000-0001-5145-9004; Maier, Alex/0000-0001-7369-1058; Mikolajczak, Sebastian/0000-0003-1996-9703 FU Foundation for the National Institutes of Health; National Institutes of Health [AI067980] FX This work was funded by a grant from the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative. Development of the SCID Alb-uPA model for P. falciparum was funded by National Institutes of Health Grant AI067980 (to J.B.S.). NR 42 TC 96 Z9 101 U1 0 U2 7 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD AUG 4 PY 2009 VL 106 IS 31 BP 13004 EP 13009 DI 10.1073/pnas.0906387106 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 479NT UT WOS:000268667600079 PM 19625622 ER PT J AU Bergmann-Leitner, ES Duncan, EH Angov, E AF Bergmann-Leitner, Elke S. Duncan, Elizabeth H. Angov, Evelina TI MSP-1p42-specific antibodies affect growth and development of intra-erythrocytic parasites of Plasmodium falciparum SO MALARIA JOURNAL LA English DT Article ID MEROZOITE SURFACE PROTEIN-1; INVASION-INHIBITORY ANTIBODIES; IN-VITRO; MALARIA VACCINE; DIRECT ACCESS; BLOOD STAGES; IMMUNITY; RECOMBINANT; FRAGMENT; ANTIGENS AB Background: Antibodies are the main effector molecules in the defense against blood stages of the malaria parasite Plasmodium falciparum. Understanding the mechanisms by which vaccine-induced anti-blood stage antibodies work in protecting against malaria is essential for vaccine design and testing. Methods: The effects of MSP-1p42-specific antibodies on the development of blood stage parasites were studied using microscopy, flow cytometry and the pLDH assay. To determine allele-specific effects, if present, allele-specific antibodies and the various parasite clones representative of these alleles of MSP-1 were employed. Results: The mode of action of anti-MSP-1p42 antibodies differs among the parasite clones tested: anti-MSP-1p42 sera act mainly through invasion-inhibitory mechanisms against FVO parasites, by either preventing schizonts from rupturing or agglutinating merozoites upon their release. The same antibodies do not prevent the rupture of 3D7 schizonts; instead they agglutinate merozoites and arrest the development of young parasites at the early trophozoite stage, thus acting through both invasion- and growth inhibitory mechanisms. The second key finding is that antibodies have access to the intra-erythrocytic parasite, as evidenced by the labeling of developing merozoites with fluorochrome-conjugated anti-MSP-1p42 antibodies. Access to the parasite through this route likely allows antibodies to exert their inhibitory activities on the maturing schizonts leading to their inability to rupture and be released as infectious merozoites. Conclusion: The identification of various modes of action by which anti-MSP-1 antibodies function against the parasite during erythrocytic development emphasizes the importance of functional assays for evaluating malaria vaccines and may also open new avenues for immunotherapy and vaccine development. C1 [Bergmann-Leitner, Elke S.; Duncan, Elizabeth H.; Angov, Evelina] Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD 20910 USA. RP Bergmann-Leitner, ES (reprint author), Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD 20910 USA. EM elke.bergmannleitner@us.army.mil; elizabeth.duncan@us.army.mil; evelina.angov@us.army.mil RI Bergmann-Leitner, Elke/B-3548-2011 OI Bergmann-Leitner, Elke/0000-0002-8571-8956 FU United States Agency for International Development [936-6001, AAG-P-00-98-00006, AAG-P-00-98-00005]; United States Army Medical Research and Materiel Command FX This work was supported by the United States Agency for International Development, Project Number 936-6001, Award Number AAG-P-00-98-00006, Award Number AAG-P-00-98-00005, and by the United States Army Medical Research and Materiel Command. NR 43 TC 22 Z9 22 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA CURRENT SCIENCE GROUP, MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD AUG 3 PY 2009 VL 8 AR 183 DI 10.1186/1475-2875-8-183 PG 12 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 486CH UT WOS:000269172600001 PM 19650894 ER PT J AU Carrion, AG Laguna-Torres, VA Soto-Castellares, G Castillo, M Salazar, E Negron, E Kolevic, L Montano, SM Sanchez, JL Bautista, CT Oberhelman, RA Kochel, TJ AF Carrion, A. G. Laguna-Torres, V. A. Soto-Castellares, G. Castillo, M. Salazar, E. Negron, E. Kolevic, L. Montano, S. M. Sanchez, J. L. Bautista, C. T. Oberhelman, R. A. Kochel, T. J. TI Molecular Characterization of the Human Immunodeficiency Virus Type 1 among Children in Lima, Peru SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID HIV TYPE-1; SOUTH-AMERICA; RECOMBINANT; BRAZIL; IDENTIFICATION; EPIDEMIC; GENES AB In Peru, there is a lack of information on molecular analysis in pediatric human immunodeficiency virus (HIV) infection. At present, the mother-to-child transmission rate is estimated at approximately 2-4%. The objective of this study was to assess the molecular epidemiology of HIV-1 in infected children. Children with suspected or confirmed pulmonary tuberculosis were evaluated at two public hospitals between 2002 and 2007. Whole blood samples were obtained from 90 HIV-positive children, who were confirmed to be positive by enzyme-linked immunosorbent assay and Western blot. The specimens were subjected to envelope heteroduplex mobility assay (env HMA) followed by gag and pol gene region sequence analysis. Subtype B was found in 88 (98%) of 90 children and 2 (2%) children were subtype BF recombinants. This is the first report of recombinant HIV strains in HIV-infected children in Peru. Understanding the origin, diversity, and spread of HIV strains worldwide will be necessary for the development of an effective vaccine that targets pediatric populations throughout the world. C1 [Carrion, A. G.; Laguna-Torres, V. A.; Montano, S. M.; Sanchez, J. L.; Bautista, C. T.; Kochel, T. J.] US Navel Med Res Ctr Detachment NMRCD, Lima 36, Peru. [Soto-Castellares, G.] Asociac Benef Prisma, Lima, Peru. [Castillo, M.; Kolevic, L.] Inst Salud Nino, Lima, Peru. [Negron, E.; Kolevic, L.] Univ Peruana Cayetano Heredia, Lima, Peru. [Bautista, C. T.] US Mil HIV Res Program, Walter Reed Army Inst Res, Rockville, MD 20850 USA. [Oberhelman, R. A.] Tulane Sch Publ Hlth & Trop Med, New Orleans, LA 70112 USA. RP Kochel, TJ (reprint author), US Navel Med Res Ctr Detachment NMRCD, Lima 36, Peru. EM tad.kochel@med.navy.mil RI Bautista, Christian/B-2812-2011 FU Department of the Navy or Army, Department of Defense, or the U.S. Government; Naval Medical Research Center Institutional Review Board [NMRCD.2002.0014, 31599, 966]; [62787A. S17.H. B0002] FX This work was funded under number 62787A. S17.H. B0002. The views expressed in this article are those of the author and do not necessarily reflect the official policy or position of the Department of the Navy or Army, Department of Defense, or the U.S. Government. The study protocol was approved by the Naval Medical Research Center Institutional Review Board ( Protocol #NMRCD. 2002.0014, DoD #31599, WRAIR #966) in compliance with all applicable Federal regulations governing the protection of human subjects. NR 15 TC 3 Z9 3 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD AUG PY 2009 VL 25 IS 8 BP 833 EP 835 DI 10.1089/aid.2009.0016 PG 3 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 483BR UT WOS:000268937300013 PM 19678768 ER PT J AU Blaylock, JM Jones, LE Lesho, E Cash, B Decker, CF AF Blaylock, Jason M. Jones, Lindsay E. Lesho, Emil Cash, Brooks Decker, Catherine F. TI Discomfort with Swallowing SO AMERICAN JOURNAL OF MEDICINE LA English DT Editorial Material ID HERPES-SIMPLEX ESOPHAGITIS; IMMUNOCOMPETENT HOST; PATIENT C1 [Decker, Catherine F.] Natl Naval Med Ctr, Div Infect Dis, Bethesda, MD 20889 USA. [Jones, Lindsay E.; Cash, Brooks] Natl Naval Med Ctr, Div Gastroenterol, Bethesda, MD 20889 USA. [Blaylock, Jason M.] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. [Lesho, Emil] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Decker, CF (reprint author), Natl Naval Med Ctr, Div Infect Dis, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM catherine.decker@med.navy.mil NR 10 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9343 J9 AM J MED JI Am. J. Med. PD AUG PY 2009 VL 122 IS 8 BP 726 EP 728 DI 10.1016/j.amjmed.2009.04.009 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 474PD UT WOS:000268295500007 PM 19635272 ER PT J AU Campbell, J AF Campbell, Jack TI VIETNAM WOMEN'S MEMORIAL SO AMERICAN JOURNAL OF NURSING LA English DT Letter C1 USA, Wayne, NJ USA. RP Campbell, J (reprint author), USA, Wayne, NJ USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0002-936X J9 AM J NURS JI Am. J. Nurs. PD AUG PY 2009 VL 109 IS 8 BP 13 EP 13 PG 1 WC Nursing SC Nursing GA 482UM UT WOS:000268914300004 PM 19641386 ER PT J AU Lowery, WJ Song, WS Leath, CA AF Lowery, William J. Song, Won S. Leath, Charles A., III TI Hot and blue Lymphoscintigraphy might be useful in cervical cancer surgery SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Editorial Material ID RADICAL HYSTERECTOMY; PELVIC LYMPHADENECTOMY; CARCINOMA C1 [Lowery, William J.; Leath, Charles A., III] Brooke Army Med Ctr, Div Gynecol Oncol, Ft Sam Houston, TX 78234 USA. [Song, Won S.] Brooke Army Med Ctr, Div Nucl Med, Ft Sam Houston, TX 78234 USA. RP Lowery, WJ (reprint author), Brooke Army Med Ctr, Div Gynecol Oncol, Ft Sam Houston, TX 78234 USA. OI Leath III, Charles/0000-0002-4034-6845 NR 4 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD AUG PY 2009 VL 201 IS 2 AR 223.e1 DI 10.1016/j.ajog.2009.02.013 PG 2 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 476RI UT WOS:000268460900037 PM 19364608 ER PT J AU Chretien, JP Tomich, NE Gaydos, JC Kelley, PW AF Chretien, Jean-Paul Tomich, Nancy E. Gaydos, Joel C. Kelley, Patrick W. TI Real-Time Public Health Surveillance for Emergency Preparedness SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material ID SYNDROMIC SURVEILLANCE; INHALATIONAL ANTHRAX; OUTBREAK; BIOTERRORISM; ATTACKS; SYSTEMS AB Public health agencies conduct surveillance to identify and prioritize health issues and evaluate interventions. Recently, natural and deliberate epidemics have motivated supplementary approaches to traditional surveillance methods based on physician and laboratory reporting. Fueled initially by post-September 11, 2001, bioterrorism-related funding, and more recently used for detecting natural outbreaks, these systems, many of which are called "syndromic" systems because they focus on syndromes recorded before the diagnosis, capture real-time health data and scan for anomalies suggesting an outbreak. Although these systems as typically implemented have often proven unreliable for detecting natural and simulated epidemics, real-time health-related data hold promise for public health. If redesigned to reliably perform beyond outbreak detection, syndromic systems could demonstrate unprecedented capabilities in responding to public health emergencies. (Am J Public Health. 2009;99:1360-1363. doi:10.2105/AJPH.2008.133926) Jean-Paul Chretien, MD, PhD, Nancy E. Tomich, BS, Joel C. Gaydos, MID, MPH, and Patrick W. Kelley, MD, DrPH C1 [Chretien, Jean-Paul; Gaydos, Joel C.] Dept Def Global Emerging Infect Surveillance & Re, Silver Spring, MD USA. [Tomich, Nancy E.] Inst Fed Hlth Care, Washington, DC USA. [Kelley, Patrick W.] Natl Acad Sci, Inst Med, Washington, DC 20418 USA. RP Chretien, JP (reprint author), Walter Reed Army Inst Res, Div Prevent Med, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM jeanpaul.chretien@us.army.mill OI Chretien, Jean-Paul/0000-0001-8143-6823 NR 28 TC 16 Z9 17 U1 0 U2 1 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD AUG PY 2009 VL 99 IS 8 BP 1360 EP 1363 DI 10.2105/AJPH.2008.133926 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 482GZ UT WOS:000268874100011 PM 19542047 ER PT J AU Leary, KJ Riel, MA Roy, MJ Cantilena, LR Bi, DQ Brater, DC van de Pol, C Pruett, K Kerr, C Veazey, JM Beboso, R Ohrt, C AF Leary, Kevin J. Riel, Michael A. Roy, Michael J. Cantilena, Louis R. Bi, Daoqin Brater, D. Craig van de Pol, Coritia Pruett, Khadeeja Kerr, Caron Veazey, James M., Jr. Beboso, Ronnie Ohrt, Colin TI A Randomized, Double-Blind, Safety and Tolerability Study to Assess the Ophthalmic and Renal Effects of Tafenoquine 200 mg Weekly versus Placebo for 6 Months in Healthy Volunteers SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID PLASMODIUM-VIVAX MALARIA; GLOMERULAR-FILTRATION-RATE; FALCIPARUM MALARIA; ANTIMALARIAL; PROPHYLAXIS; IOTHALAMATE; PRIMAQUINE; EFFICACY; RELAPSE; TRIAL AB A randomized. double-blind. placebo-controlled Study was conducted to assess the effect of tafenoquine., 200 mg weekly for 6 months on Ophthalmic and renal safety. This trial was carried Out after observations in previous clinical trials that tafenoquine may be associated with the development of corneal deposits and elevations in serum creatinine. In 120 healthy Volunteers who received tafenoquine or placebo in a 2:1 randomization, there Was no effect oil night vision or other ophthalmic indices measured. Persons taking tafenoquine also showed no difference in mean change in glomerular filtration rate (GFR, mL/s/1.73 m(2)) after 6 months of closing, with a treatment difference of -0.061 (95%-confidence interval, -0.168,0.045), and non-inferiority margin of -0.247 mL/s/1.73 m(2). Tafenoquine was well tolerated over the course Of the study. The results of this study showed no clinically significant effects of tafenoquine on Ophthalmic or renal function, and support its continued development as an antimalarial drug. C1 [Leary, Kevin J.; Veazey, James M., Jr.] USA, Med Mat Dev Act, Ft Detrick, MD 21702 USA. [Ohrt, Colin] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Beboso, Ronnie] Chiltern Early Phase Ltd Ninewells Hosp & Med Sch, Dundee DD1 9SY, Scotland. [Pruett, Khadeeja; Kerr, Caron] GlaxoSmithKline Res & Dev Ltd, Greenford UB6 0HE, Middx, England. [van de Pol, Coritia] Acufocus Inc, Irvine, CA 92618 USA. [Brater, D. Craig] Indiana Univ, Sch Med, Indianapolis, IN 46202 USA. [Leary, Kevin J.; Riel, Michael A.; Roy, Michael J.; Cantilena, Louis R.; Bi, Daoqin] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Chiltern Int Ltd, Early Phase Unit, Slough, Berks, England. RP Leary, KJ (reprint author), USA, Med Mat Dev Act, 1430 Vet Dr, Ft Detrick, MD 21702 USA. EM kevin.leary1@us.army.mil FU GlaxoSmithKline (Brentford, Middlesex. UK); U.S. Army Medical Research and Materiel Command FX This study Was Supported by GlaxoSmithKline (Brentford, Middlesex. UK) and the U.S. Army Medical Research and Materiel Command. NR 24 TC 10 Z9 10 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD AUG PY 2009 VL 81 IS 2 BP 356 EP 362 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 475LK UT WOS:000268360400033 PM 19635898 ER PT J AU Miao, N Levin, SW Baker, EH Caruso, RC Zhang, ZJ Gropman, A Koziol, D Wesley, R Mukherjee, AB Quezado, ZMN AF Miao, Ning Levin, Sondra W. Baker, Eva H. Caruso, Rafael C. Zhang, Zhongjian Gropman, Andrea Koziol, Deloris Wesley, Robert Mukherjee, Anil B. Quezado, Zenaide M. N. TI Children with Infantile Neuronal Ceroid Lipofuscinosis Have an Increased Risk of Hypothermia and Bradycardia During Anesthesia SO ANESTHESIA AND ANALGESIA LA English DT Article ID PALMITOYL-PROTEIN THIOESTERASE; BATTEN-DISEASE; TEMPERATURE; SEVOFLURANE; MANAGEMENT; PATIENT; NCL AB BACKGROUND: Neuronal ceroid lipofuscinoses (NCLs) are a group of autosomal recessive neurodegenerative diseases characterized by lysosomal accumulation of autofluorescent material in neurons and other cell types. The infantile NCL (INCL) subtype is rare (1 in >100,000 births), the most devastating of childhood subtypes, and is caused by mutations in the gene CLN1, which encodes palmitoyl-protein thioesterase-1. METHODS: To investigate the incidence of hypothermia and bradycardia during general anesthesia in patients with INCL, we conducted a case-control study to examine the perianesthetic course of patients with INCL and of controls receiving anesthesia for diagnostic studies. RESULTS: Eight children with INCL (mean age 25 mo [range, 10-32] at first anesthetic) and 25 controls (mean age 44 mo [range, 18-92]) underwent 62 anesthetics for nonsurgical procedures. Patients with INCL had neurologic deficits including developmental delay, myoclonus, and visual impairment. Patients with INCL had lower baseline temperature (36.4 +/- 0.1 vs 36.8 +/- 0.1, INCL versus controls, P < 0.007), and during anesthesia, despite active warming techniques, had significantly more hypothermia (18 vs 0 episodes, P < 0.001) and sinus bradycardia (10 vs 1, P < 0.001) compared with controls. INCL diagnosis was significantly associated with temperature decreases during anesthesia (P < 0.001), whereas age, sex, and duration of anesthesia were not (P = NS). CONCLUSIONS: We report that patients with LNCL have lower baseline body temperature and during general anesthesia, despite rewarming interventions, are at increased risk for hypothermia and bradycardia. This suggests a previously unknown INCL phenotype, impaired thermoregulation. Therefore, when anesthetizing these children, careful monitoring and routine use of warming interventions are warranted. (Anesth Analg 2009109:372-8) C1 [Miao, Ning; Quezado, Zenaide M. N.] NIH, Dept Anesthesia & Surg Serv, Ctr Clin, Bethesda, MD 20892 USA. [Levin, Sondra W.; Zhang, Zhongjian; Mukherjee, Anil B.] NICHHD, Sect Dev Genet, Program Dev Endocrinol & Genet, Bethesda, MD 20892 USA. [Levin, Sondra W.] Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. [Baker, Eva H.] NIH, Dept Diagnost Radiol, Ctr Clin, Bethesda, MD 20892 USA. [Caruso, Rafael C.] NEI, Visual Funct Sect, Ophthalm Genet & Visual Funct Branch, Bethesda, MD 20892 USA. [Gropman, Andrea] Childrens Natl Med Ctr, Dept Neurol, Washington, DC 20010 USA. [Gropman, Andrea] NHGRI, Med Genet Branch, Bethesda, MD 20892 USA. [Koziol, Deloris; Wesley, Robert] NIH, Biostat & Clin Epidemiol Serv, Off Director, Ctr Clin, Bethesda, MD 20892 USA. RP Quezado, ZMN (reprint author), NIH, Dept Anesthesia & Surg Serv, Ctr Clin, 10 Ctr Dr,MSC-1512,Bldg 10,Room 2C624, Bethesda, MD 20892 USA. EM zquezado@nih.gov RI Quezado, Zenaide/O-4860-2016 OI Quezado, Zenaide/0000-0001-9793-4368 FU National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; NTH Clinical Center FX Supported by the Intramural Research Program of the National Institutes of Health, the Eunice Kennedy Shriver National Institute of Child Health and Human Development and the NTH Clinical Center. NR 24 TC 8 Z9 8 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD AUG PY 2009 VL 109 IS 2 BP 372 EP 378 DI 10.1213/ane.0b013e3181aa6e95 PG 7 WC Anesthesiology SC Anesthesiology GA 474QH UT WOS:000268298600014 PM 19608805 ER PT J AU Cohen, SP Kapoor, SG Rathmell, JP AF Cohen, Steven P. Kapoor, Shruti G. Rathmell, James P. TI Intravenous Infusion Tests Have Limited Utility for Selecting Long-term Drug Therapy in Patients with Chronic Pain A Systematic Review SO ANESTHESIOLOGY LA English DT Review ID CHRONIC NONCANCER PAIN; METHYL-D-ASPARTATE; SYMPATHETICALLY-MAINTAINED PAIN; RANDOMIZED CONTROLLED-TRIALS; DORSAL-ROOT-GANGLIA; ORAL DEXTROMETHORPHAN TREATMENT; PREDICTS SUBSEQUENT RESPONSE; CHRONIC NONMALIGNANT PAIN; PERIPHERAL-NERVE INJURY; LOW-BACK-PAIN AB Since the first description in the early 1990s, the scope of intravenous infusions tests has expanded to encompass multiple drug classes and indications. Purported advantages of these tests include elucidating mechanisms of pain, providing temporary relief of symptoms, and usefulness as prognostic tools in guiding drug therapy. in an attempt to discern the value of these tests, the authors conducted a systematic review to explore the rationale and evidence behind the following intravenous infusion tests: lidocaine, ketamine, opioid, and phentolamine. The studies evaluating all intravenous infusion tests were characterized by lack of standardization, wide variations in outcome measures, and methodological flaws. The strongest evidence found was for the intravenous lidocaine test, with the phentolamine test characterized by the least convincing data. Whereas intravenous opioid infusions are the most conceptually appealing test, their greatest utility may be in predicting poor responders to sustained-release formulations. C1 [Cohen, Steven P.] Johns Hopkins Sch Med, Dept Anesthesiol, Pain Management Div, Baltimore, MD USA. [Cohen, Steven P.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Cohen, SP (reprint author), Johns Hopkins Pain Management Div, 550 N Broadway,Suite 301, Baltimore, MD 21029 USA. EM scohen40@jhmi.edu FU John P. Murtha Neuroscience and Pain Institute, Johnstown, Pennsylvania; Army Regional Anesthesia & Pain Medicine Initiative, Washington, D.C FX Funded in part by the John P. Murtha Neuroscience and Pain Institute, Johnstown, Pennsylvania, and the Army Regional Anesthesia & Pain Medicine Initiative, Washington, D.C. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of t he Department of the Army or the Department of Defense. Mark A. Warner, M.D., served as Handling Editor for this article. NR 147 TC 13 Z9 13 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-3022 EI 1528-1175 J9 ANESTHESIOLOGY JI Anesthesiology PD AUG PY 2009 VL 111 IS 2 BP 416 EP 431 PG 16 WC Anesthesiology SC Anesthesiology GA 475FB UT WOS:000268342700025 PM 19602955 ER PT J AU Roxas-Duncan, V Enyedy, I Montgomery, VA Eccard, VS Carrington, MA Lai, HG Gul, N Yang, DCH Smith, LA AF Roxas-Duncan, Virginia Enyedy, Istvan Montgomery, Vicki A. Eccard, Vanessa S. Carrington, Marco A. Lai, Huiguo Gul, Nizamettin Yang, David C. H. Smith, Leonard A. TI Identification and Biochemical Characterization of Small-Molecule Inhibitors of Clostridium botulinum Neurotoxin Serotype A SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID LIGHT-CHAIN; PHARMACOLOGICAL ANTAGONISTS; ANTIMICROBIAL ACTIVITY; SUBSTRATE-SPECIFICITY; ZINC-ENDOPEPTIDASE; CRYSTAL-STRUCTURE; PROTEASE ACTIVITY; NERVE-TERMINALS; MOTOR NERVES; IN-VITRO AB An integrated strategy that combined in silico screening and tiered biochemical assays (enzymatic, in vitro, and ex vivo) was used to identify and characterize effective small-molecule inhibitors of Clostridium botulinum neurotoxin serotype A (BoNT/A). Virtual screening was initially performed by computationally docking compounds of the National Cancer Institute (NCI) database into the active site of BoNT/A light chain (LC). A total of 100 high-scoring compounds were evaluated in a high-performance liquid chromatography (HPLC)-based protease assay using recombinant full-length BoNT/A LC. Seven compounds that significantly inhibited the BoNT/A protease activity were selected. Database search queries of the best candidate hit [7-((4-nitroanilino)(phenyl)methyl)-8-quinolinol (NSC 1010)] were performed to mine its nontoxic analogs. Fifty-five analogs of NSC 1010 were synthesized and examined by the HPLC-based assay. Of these, five quinolinol derivatives that potently inhibited both full-length BoNT/A LC and truncated BoNT/A LC ( residues 1 to 425) were selected for further inhibition studies in neuroblastoma (N2a) cell-based and tissue-based mouse phrenic nerve hemidiaphragm assays. Consistent with enzymatic assays, in vitro and ex vivo studies revealed that these five quinolinol-based analogs effectively neutralized BoNT/A toxicity, with CB 7969312 exhibiting ex vivo protection at 0.5 mu M. To date, this is the most potent BoNT/A small-molecule inhibitor that showed activity in an ex vivo assay. The reduced toxicity and high potency demonstrated by these five compounds at the biochemical, cellular, and tissue levels are distinctive among the BoNT/A small-molecule inhibitors reported thus far. This study demonstrates the utility of a multidisciplinary approach (in silico screening coupled with biochemical testing) for identifying promising small-molecule BoNT/A inhibitors. C1 [Roxas-Duncan, Virginia; Montgomery, Vicki A.; Eccard, Vanessa S.; Carrington, Marco A.; Gul, Nizamettin; Smith, Leonard A.] USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. [Enyedy, Istvan] Georgetown Univ, Lombardi Canc Ctr, Washington, DC 20057 USA. [Lai, Huiguo; Yang, David C. H.] Georgetown Univ, Dept Chem, Washington, DC 20057 USA. RP Smith, LA (reprint author), USA, Med Res Inst Infect Dis, Integrated Toxicol Div, 1425 Porter St, Ft Detrick, MD 21702 USA. EM leonard.smith@amedd.army.mil RI Yang, David/A-7294-2009 FU Defense Threat Reduction Agency/JSTO-CBD [3.10037_07_RD_B] FX This work was supported by Defense Threat Reduction Agency/JSTO-CBD project number 3.10037_07_RD_B.; We are grateful to James Schmidt, John Cardellina, Theresa J. Smith, Frank Lebeda, and Minghao Feng for helpful discussions and comments. We thank Yvette Campbell, Jennifer Brown, Janet Skerry, James Kenney, and Gordon Ruthel for their valuable technical support; Robert P. Webb for cloning and expressing rELC and tALC; Patrick Wright for providing purified rELC; and Lorraine Farinick for assistance with graphics.; The opinions, interpretations, conclusions, and recommendations herein are those of the authors and are not necessarily endorsed by the U. S. Army. NR 49 TC 45 Z9 46 U1 0 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD AUG PY 2009 VL 53 IS 8 BP 3478 EP 3486 DI 10.1128/AAC.00141-09 PG 9 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 471ZW UT WOS:000268098300044 PM 19528275 ER PT J AU Alberts, WCK Noble, JM Coleman, MA AF Alberts, W. C. Kirkpatrick, II Noble, John M. Coleman, Mark A. TI On the application of well-known diffraction models to the sound field in the shadow zone of an isolated building SO APPLIED ACOUSTICS LA English DT Letter ID BARRIERS; PROPAGATION; WIDE C1 [Alberts, W. C. Kirkpatrick, II; Noble, John M.; Coleman, Mark A.] USA, Res Lab, ATTN AMSRD ARL CI ES, Adelphi, MD 20783 USA. RP Alberts, WCK (reprint author), USA, Res Lab, ATTN AMSRD ARL CI ES, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM kirk.alberts@us.army.mil NR 12 TC 2 Z9 3 U1 1 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0003-682X J9 APPL ACOUST JI Appl. Acoust. PD AUG PY 2009 VL 70 IS 8 BP 1128 EP 1130 DI 10.1016/j.apacoust.2009.02.002 PG 3 WC Acoustics SC Acoustics GA 556IH UT WOS:000274583800014 ER PT J AU Florio, LA AF Florio, L. A. TI Finite-volume modelling of system with compressible flow propelled and actuated body motion SO APPLIED MATHEMATICAL MODELLING LA English DT Article DE Computational; Fluid flow; Compressible; Pressure waves; Moving body ID TRANSIENT FLOW; COMBUSTION AB A finite-volume model for the gas flow in a compressible flow driven system with two moving components is developed and applied. In this system, high pressure and temperature compressible flow propels one body along a main flow channel. When this body passes an opening in the main flow channel, some of the high pressure gas bleeds off, entering a secondary, telescoping, flow channel that empties into a plenum. The bleed-off flow causes the pressure in the plenum to increase, actuating the motion of a secondary (actuated) body that forms a bounding surface of the plenum, causing the plenum to expand and the secondary channel to lengthen. This model is used to characterize the basic now effects in the system and to investigate the significance of the system parameters. For the parameters studied, the flow in the system consists of a series of pressure pulses rather than a continuous flow, with reflected pressure waves playing a significant role in the flow field development. For a given initial pressure, changing the size of the opening and secondary flow channel had a minimal effect on the motion of the propelled body. The size of the opening and the initial high pressure were found to have the greatest impact on the velocity of the secondary, actuated moving body. Published by Elsevier Inc. C1 USA, ARDEC, Technol Branch, Small & Medium Caliber Armaments Div,AMSRD AAR WS, Picatinny Arsenal, NJ 07806 USA. RP Florio, LA (reprint author), USA, ARDEC, Technol Branch, Small & Medium Caliber Armaments Div,AMSRD AAR WS, Bldg 65N, Picatinny Arsenal, NJ 07806 USA. EM laurie.florio@us.army.mil FU In-House Laboratory Independent Research Program [AR-0101975/FJ5R] FX This work was funded by the In-House Laboratory Independent Research Program - AR-0101975/FJ5R. The author wishes to acknowledge D. Cler and US ARMY Armaments Research, Development and Engineering Center's Benet Labs, Watervliet, New York for assistance and usage of FLUENT licenses. NR 29 TC 2 Z9 2 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0307-904X J9 APPL MATH MODEL JI Appl. Math. Model. PD AUG PY 2009 VL 33 IS 8 BP 3360 EP 3381 DI 10.1016/j.apm.2008.11.005 PG 22 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications; Mechanics SC Engineering; Mathematics; Mechanics GA 446SA UT WOS:000266140200008 ER PT J AU Russo, MB Stetz, MC Jenkins, CM Folen, RA AF Russo, Michael B. Stetz, Melba C. Jenkins, Craig M. Folen, Ray A. TI Armodafinil for the Treatment of Excessive Sleepiness SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Editorial Material ID APNEA; ACCIDENTS; FLIGHT C1 [Russo, Michael B.; Stetz, Melba C.; Jenkins, Craig M.; Folen, Ray A.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Russo, MB (reprint author), Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD AUG PY 2009 VL 80 IS 8 BP 743 EP 744 DI 10.3357/ASEM.21006.2009 PG 2 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 477SL UT WOS:000268538900013 PM 19653582 ER PT J AU Banez, LL Blake, GW McLeod, DG Crawford, ED Moul, JW AF Banez, Lionel L. Blake, Gary W. McLeod, David G. Crawford, E. David Moul, Judd W. TI Combined low-dose flutamide plus finasteride vs low-dose flutamide monotherapy for recurrent prostate cancer: a comparative analysis of two phase II trials with a long-term follow-up SO BJU INTERNATIONAL LA English DT Article DE prostatic neoplasms; PSA recurrence; hormonal therapy; flutamide; finasteride ID INTERMITTENT ANDROGEN SUPPRESSION; RADICAL PROSTATECTOMY; BIOCHEMICAL RECURRENCE; HORMONAL-THERAPY; PHASE-II; COMBINATION; SURVIVAL; ANTIGEN; MEN AB OBJECTIVE To compare the efficacy and tolerability of peripheral androgen blockade using combined low-dose flutamide plus finasteride vs low-dose flutamide monotherapy for treating biochemical relapse after the definitive management of prostate adenocarcinoma. PATIENTS AND METHODS Fifty-six men treated for biochemical relapse of prostate cancer were enrolled prospectively in a phase II trial at the Walter Reed Army Medical Center from 1997 to 2001. Thirty-six men were treated with flutamide (125 mg twice daily) and finasteride (5 mg twice daily), and 20 men received low-dose flutamide only after biochemical recurrence (prostate-specific antigen, PSA, level >= 0.4 ng/mL). Cox proportional hazards analyses were used to compare the risk of progression between the groups. RESULTS Patients on combined and monotherapy had a median follow-up of 54 and 43.5 months, respectively. Seven men (19%) in the combined arm remain in the study with no progression, while five (25%) on monotherapy continue and are progression-free. Men on combined therapy had a greater decrease in their PSA level (P = 0.002). Multivariate analysis showed that men on combined therapy had significantly less risk of progression than men on monotherapy (hazard ratio 0.21, 95% confidence interval 0.07-0.63, P = 0.005). There was no significant difference in the frequency of side-effects between the groups. Toxicities were reported to be mild. CONCLUSIONS Our analysis suggests the therapeutic value of low-dose flutamide alone or combined with finasteride as first-line agents in a possible graduated approach for treating PSA-only recurrent prostate cancer. Due to unwanted metabolic effects associated with traditional hormonal agents, phase III trials comparing both regimens with current therapies are warranted. C1 [Banez, Lionel L.; Moul, Judd W.] Duke Univ, Med Ctr, Div Urol Surg, Durham, NC 27710 USA. [Banez, Lionel L.; Moul, Judd W.] Duke Univ, Med Ctr, Dept Surg, Duke Prostate Ctr, Durham, NC 27710 USA. [Blake, Gary W.; McLeod, David G.] Walter Reed Army Med Ctr, Ctr Prostate Dis Res, Washington, DC 20307 USA. [Blake, Gary W.; McLeod, David G.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Crawford, E. David] Univ Colorado, Hlth Sci Ctr, Ctr Canc, Denver, CO 80262 USA. RP Moul, JW (reprint author), Duke Univ, Med Ctr, Div Urol Surg, Box 3707, Durham, NC 27710 USA. EM judd.moul@duke.edu FU Duke University Medical Center; Department of Defense; Center for Prostate Disease Research; Henry M. Jackson Foundation FX Supported by: The Division of Urologic Surgery and the Duke Prostate Center, Department of Surgery, Duke University Medical Center, the Department of Defense, the Center for Prostate Disease Research and the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. NR 20 TC 8 Z9 9 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1464-4096 J9 BJU INT JI BJU Int. PD AUG PY 2009 VL 104 IS 3 BP 310 EP 314 DI 10.1111/j.1464-410X.2009.08400.x PG 5 WC Urology & Nephrology SC Urology & Nephrology GA 469FA UT WOS:000267879900008 PM 19239458 ER PT J AU Brunye, TT Mahoney, CR Augustyn, JS Taylor, HA AF Brunye, Tad T. Mahoney, Caroline R. Augustyn, Jason S. Taylor, Holly A. TI Horizontal saccadic eye movements enhance the retrieval of landmark shape and location information SO BRAIN AND COGNITION LA English DT Article DE Bilateral eye movements; Hemispheric interaction; Episodic memory; Spatial memory ID POSITRON-EMISSION-TOMOGRAPHY; INCREASED INTERHEMISPHERIC INTERACTION; EPISODIC MEMORY; RECOGNITION MEMORY; CORPUS-CALLOSUM; PREFRONTAL CORTEX; HEMISPHERIC-SPECIALIZATION; SPATIAL LOCATION; OBJECT IDENTITY; WORKING-MEMORY AB Recent work has demonstrated that horizontal saccadic eye movements enhance verbal episodic memory retrieval, particularly in strongly right-handed individuals. The present experiments test three primary assumptions derived from this research. First, horizontal eye movements should facilitate episodic memory for both verbal and non-verbal information. Second, the benefits of horizontal eye movements should only be seen when they immediately precede tasks that demand right and left-hemisphere processing towards Successful performance. Third, the benefits of horizontal eye movements should be most pronounced in the strongly right-handed. Two experiments confirmed these hypotheses: horizontal eye movements increased recognition sensitivity and decreased response times during a spatial memory test relative to both vertical eye movements and fixation. These effects were only seen when horizontal eye movements preceded episodic memory retrieval, and not when they preceded encoding (Experiment 1). Further, when eye movements preceded retrieval, they were only beneficial with recognition tests demanding a high degree of right and left-hemisphere activity (Experiment 2). In both experiments the beneficial effects of horizontal eye movements were greatest for strongly right-handed individuals. These results support recent work suggesting increased interhemispheric brain activity induced by bilateral horizontal eye movements, and extend this literature to the encoding and retrieval of landmark shape and location information. Published by Elsevier Inc. C1 [Brunye, Tad T.; Mahoney, Caroline R.; Taylor, Holly A.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. [Brunye, Tad T.; Mahoney, Caroline R.; Augustyn, Jason S.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Brunye, TT (reprint author), Tufts Univ, Dept Psychol, 490 Boston Ave, Medford, MA 02155 USA. EM tbruny01@tufts.edu FU United States Army Natick Soldier Research, Development and Engineering Center FX This work was supported by a contract from the United States Army Natick Soldier Research, Development and Engineering Center. The opinions expressed herein are those of the authors and do not reflect those of the United States Army. We thank William Shirer and several research assistants for their careful data collection and scoring. We also thank Keith Lyle, Andrew Parker, and Ruth Propper for their helpful and thorough comments on earlier versions of this manuscript. NR 61 TC 19 Z9 20 U1 3 U2 8 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0278-2626 J9 BRAIN COGNITION JI Brain Cogn. PD AUG PY 2009 VL 70 IS 3 BP 279 EP 288 DI 10.1016/j.bandc.2009.03.003 PG 10 WC Neurosciences; Psychology, Experimental SC Neurosciences & Neurology; Psychology GA 450QO UT WOS:000266416100006 PM 19346050 ER PT J AU Aarons, C Potter, BK Adams, SC Pitcher, JD Temple, HT AF Aarons, Chad Potter, Benjamin K. Adams, Sheila C. Pitcher, J. David, Jr. Temple, H. Thomas TI Extended Intralesional Treatment versus Resection of Low-grade Chondrosarcomas SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article ID GIANT-CELL TUMOR; BONE-TUMORS; I CHONDROSARCOMA; LONG BONES; LOWER-LIMB; FOLLOW-UP; CRYOSURGERY; ENCHONDROMA; RECURRENCE; MANAGEMENT AB The need for segmental resection versus intralesional treatment of low-grade chondrosarcomas of the appendicular skeleton remains controversial. We hypothesized extended intralesional treatment would equally control malignant disease but with improved functional outcomes and decreased postoperative complications. We retrospectively reviewed 31 patients with 32 Grade I intracompartmental chondrosarcomas of the long bones of the appendicular skeleton treated with either resection (15 lesions) or extended intralesional curetting (17) at a minimum followup of 2 years (median, 55 months; range, 24-203 months). Lesions were larger and median followup was longer in the resection cohort. One local recurrence developed in each treatment cohort and neither transitioned to a higher grade of tumor. No patient had metastases develop or died of disease. The mean final Musculoskeletal Tumor Society functional scores were greater after extended intralesional versus resection treatment (29.5 versus 25.1). Complications were observed more frequently after resection and reconstruction (seven of 15) as compared with extended intralesional treatment (one of 17). Extended intralesional treatment of Grade I intracompartmental chondrosarcomas of the long bones of the appendicular skeleton therefore appears safe with improved functional scores and decreased complications versus segmental resection and reconstruction. Level of Evidence: Level III, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence. C1 [Potter, Benjamin K.] Walter Reed Army Med Ctr, Integrated Dept Orthopaed & Rehabil, Washington, DC 20307 USA. [Aarons, Chad; Potter, Benjamin K.; Adams, Sheila C.; Pitcher, J. David, Jr.; Temple, H. Thomas] Univ Miami, Miller Sch Med, Dept Orthopaed, Miami, FL 33136 USA. RP Potter, BK (reprint author), Walter Reed Army Med Ctr, Integrated Dept Orthopaed & Rehabil, 6900 Georgia Ave NW,Bldg 2A,Room 205, Washington, DC 20307 USA. EM Benjamin.Potter@amedd.army.mil OI Potter, MD, Benjamin K./0000-0002-8771-0317 NR 46 TC 20 Z9 22 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0009-921X EI 1528-1132 J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD AUG PY 2009 VL 467 IS 8 BP 2105 EP 2111 DI 10.1007/s11999-008-0691-8 PG 7 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 467YH UT WOS:000267779100026 PM 19142690 ER PT J AU Nemelka, KW Brown, AW Wallace, SM Jones, E Asher, LV Pattarini, D Applebee, L Gilliland, TC Guerry, P Baqar, S AF Nemelka, Kevin W. Brown, Ammon W. Wallace, Shannon M. Jones, Erika Asher, Ludmila V. Pattarini, Dawn Applebee, Lisa Gilliland, Theron C., Jr. Guerry, Patricia Baqar, Shahida TI Immune Response to and Histopathology of Campylobacter jejuni Infection in Ferrets (Mustela putorius furo) SO COMPARATIVE MEDICINE LA English DT Article ID DIARRHEAL ILLNESS; INTRACELLULAR SURVIVAL; MILITARY PERSONNEL; GUILLAIN-BARRE; MODEL; COLONIZATION; CELLS; MICE; VIRULENCE; THAILAND AB Campylobacter jejuni is 1 of the most common enteric bacterial pathogens worldwide. The mechanisms of pathogenesis remain obscure, in part because of limitations of small animal models. Young ferrets develop diarrhea when fed C. jejuni, but their pathology and the immune response after infection have not been examined in detail. In the present study, we examined the pathogenesis of C. jejuni CG8421 and associated immune responses in ferrets. After oral infection with C. jejuni CG8421,86.7% of the animals developed diarrhea and inflammatory responses that were similar to those seen in human infection. Pronounced histopathologic changes in the colonic mucosa of infected animals were observed during the acute phase (days 1 through 3) of infection. Electron micrographs of colonic epithelium revealed disruption of the villi and internalized bacteria that were not within membrane vacuoles. During the acute phase, C. jejuni was isolated from the livers of 7 of 9 (78%) animals, and bacteria were visualized immunohistochemically in the livers from 5 of the 7 animals (71%) from which C. jejuni was isolated. A vigorous systemic and mucosal immune response to Campylobacter antigens was elicited after infection of ferrets. The data presented contribute to the current knowledge of the pathogenicity of and immunologic response to C. jejuni CG8421 in ferrets and better understanding of this model. C1 [Nemelka, Kevin W.] Walter Reed Army Inst Res, Div Vet Med, Silver Spring, MD USA. [Brown, Ammon W.; Wallace, Shannon M.; Asher, Ludmila V.] Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD USA. [Jones, Erika; Pattarini, Dawn; Applebee, Lisa; Gilliland, Theron C., Jr.; Guerry, Patricia; Baqar, Shahida] USN, Med Res Ctr, Enter Dis Dept, Silver Spring, MD USA. RP Nemelka, KW (reprint author), Walter Reed Army Inst Res, Div Vet Med, Silver Spring, MD USA. EM Kevin.nemelka@amedd.army.mil RI Guerry, Patricia/A-8024-2011 FU US Navy Research and Development Command Work Units [6000.RAD1.DA3.A0308] FX These studies were supported by US Navy Research and Development Command Work Units 6000.RAD1.DA3.A0308. The authors have no conflicting financial interests. KWN, AWB, SMK LVA, PG, and SB are employees of the US Government. This work was prepared as part of their official duties. Title 17 USC 101 defines a US Government work as a work prepared by a military service member or employee of the US Government as part of that person's official duties. NR 52 TC 8 Z9 8 U1 0 U2 0 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1532-0820 J9 COMPARATIVE MED JI Comparative Med. PD AUG PY 2009 VL 59 IS 4 BP 363 EP 371 PG 9 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 489IF UT WOS:000269413000009 PM 19712577 ER PT J AU Rao, MP Duan, Y Keefe, M Powers, BM Bogetti, TA AF Rao, M. P. Duan, Y. Keefe, M. Powers, B. M. Bogetti, T. A. TI Modeling the effects of yarn material properties and friction on the ballistic impact of a plain-weave fabric SO COMPOSITE STRUCTURES LA English DT Article DE Ballistic impact; Yarn material properties; Friction; Woven fabric; Finite element analysis ID PERFORATION; ARMOR; PROJECTILES; SIMULATION; BEHAVIOR; ENERGY; SYSTEM AB Impact of a rigid sphere onto a high-strength plain-weave Kevlar KM2 (R) fabric was modeled using LS-DYNA (R) focusing on the influence of friction and material properties on ballistic performance. Quasi-static friction was experimentally determined and incorporated into the model. Two clamped edges and two free edges were used as boundary conditions to correlate the model to an experimental test providing yarn-yarn movement. Yarns were modeled as continua with modulus and strength dominating along the length. Parametric studies incorporating different yarn material properties and initial projectile velocities were then performed with the above set of boundary conditions. Results indicate that ballistic performance depends upon friction, elastic modulus and strength of the yams. While friction improves ballistic performance by maintaining the integrity of the weave pattern, material properties of the yarns have a significant influence on the effect of friction. It is shown that fabrics comprised of yarns characterized by higher stiffness and strength relative to the baseline Kevlar KM2 (R), exhibited a stronger influence on ballistic performance. Therefore all three parameters viz., friction, elastic modulus and strength along with other variables (fabric architecture, boundary conditions, and projectile parameters) are needed to examine ballistic performance of high-strength fabric structures. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Keefe, M.] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. [Rao, M. P.; Duan, Y.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. [Powers, B. M.; Bogetti, T. A.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Keefe, M (reprint author), Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. EM keefe@udel.edu RI Duan, Yiping/A-5541-2011; Rao, Prabhakar/B-1415-2010 FU United States Army Research Laboratory, Aberdeen Proving Ground; Center for Composite Materials, University of Delaware FX The authors gratefully acknowledge the support of the United States Army Research Laboratory, Aberdeen Proving Ground, and the Center for Composite Materials, University of Delaware, during this research. NR 25 TC 87 Z9 93 U1 1 U2 39 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0263-8223 J9 COMPOS STRUCT JI Compos. Struct. PD AUG PY 2009 VL 89 IS 4 BP 556 EP 566 DI 10.1016/j.compstruct.2008.11.012 PG 11 WC Materials Science, Composites SC Materials Science GA 453RQ UT WOS:000266629100008 ER PT J AU Sevkat, E Liaw, B Delale, F Raju, BB AF Sevkat, Ercan Liaw, Benjamin Delale, Feridun Raju, Basavaraju B. TI Drop-weight impact of plain-woven hybrid glass-graphite/toughened epoxy composites SO COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING LA English DT Article DE Hybrid composites; Impact behavior; Finite element analysis (FEA); Ultrasonic ID LOW-VELOCITY IMPACT; PROGRESSIVE DAMAGE; FIBER COMPOSITES; FAILURE AB The progressive damage behaviors of hybrid woven composite panels (101.6 num x 101.6 mm) impacted by drop-weights at four different velocities were studied by a combined experimental and 3-D dynamic nonlinear finite element approach. The specimens tested were made of plain-weave hybrid S2 glass-IM7 graphite fibers/toughened epoxy (cured at 177 degrees C). The composite panels were damaged using a pressure-assisted Instron-Dynatup 8520 instrumented drop-weight impact tester. During these low-velocity simpact tests, the time-histories of impact-induced dynamic strains and impact forces were recorded. The damaged specimens were inspected visually and using ultrasonic C-Scan methods. The commercially available 3-D dynamic nonlinear finite element (FE) software, LS-DYNA, incorporated with a proposed user-defined damage-induced nonlinear orthotropic model, was then used to simulate the experimental results of drop-weight tests. Good agreement between experimental and FE results has been achieved when comparing dynamic force, strain histories and damage patterns from experimental measurements and FE simulations. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Liaw, Benjamin; Delale, Feridun] CUNY City Coll, Dept Mech Engn, New York, NY 10031 USA. [Sevkat, Ercan] New York City Coll Technol, Dept Mech Engn Technol, Brooklyn, NY 11201 USA. [Raju, Basavaraju B.] USA, RDECOM, TARDEC, Warren, MI USA. RP Liaw, B (reprint author), CUNY City Coll, Dept Mech Engn, 140th & Convent Ave, New York, NY 10031 USA. EM liaw@ccny.cuny.edu FU US Army Research Office [DAAD19-03-1-00086]; City University of New York through CUNY Collaborative Incentive Research [80209-06 10]; CUNY Research Equipment Grant Competition [80212-12 04] FX This work is supported by US Army Research Office through Grant No. DAAD19-03-1-00086. Dr. Bruce LaMattina is the Program Manager. The authors also would like to express their thanks for funding from City University of New York through CUNY Collaborative Incentive Research Grants Program (80209-06 10) and CUNY Research Equipment Grant Competition (80212-12 04) for procuring part of the materials and equipment used in this research. NR 30 TC 58 Z9 58 U1 1 U2 23 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-835X J9 COMPOS PART A-APPL S JI Compos. Pt. A-Appl. Sci. Manuf. PD AUG PY 2009 VL 40 IS 8 BP 1090 EP 1110 DI 10.1016/j.compositesa.2009.04.028 PG 21 WC Engineering, Manufacturing; Materials Science, Composites SC Engineering; Materials Science GA 487SK UT WOS:000269295700014 ER PT J AU Cook, JA Harrison, SA AF Cook, J. Aaron Harrison, Stephen A. TI Same Day Endoscopy and Percutaneous Liver Biopsy: Safety and Cost-Effectiveness SO DIGESTIVE DISEASES AND SCIENCES LA English DT Article DE Liver biopsy; Endoscopy; Safety; Cost-effective; Patient satisfaction AB Routine upper and/or lower endoscopy and percutaneous liver biopsy in the same patient are rarely performed on the same day. The aim of this study was to determine the safety, cost savings, and patient satisfaction of these same day procedures. A retrospective cohort study of patients undergoing same day endoscopy and percutaneous liver biopsy between February 2003 and July 2006 at Brooke Army Medical Center was performed. Eighty-nine patients were identified as having same day endoscopy and percutaneous liver biopsy during the study period. No study endpoint complications were identified. A cost savings of $333 per patient for a same day diagnostic upper endoscopy, colonoscopy, and percutaneous liver biopsy was found. More patients in both groups preferred same day procedures (P < 0.001). In conclusion, endoscopy and percutaneous liver biopsy can safely be performed in the same patient on the same day, which simultaneously increases patient satisfaction and is cost-effective. C1 [Cook, J. Aaron; Harrison, Stephen A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Harrison, SA (reprint author), Brooke Army Med Ctr, 3841 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Stephen.harrison@amedd.army.mil NR 4 TC 2 Z9 2 U1 0 U2 0 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0163-2116 J9 DIGEST DIS SCI JI Dig. Dis. Sci. PD AUG PY 2009 VL 54 IS 8 BP 1753 EP 1757 DI 10.1007/s10620-008-0544-z PG 5 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 464DM UT WOS:000267485400023 PM 19034662 ER PT J AU Petrikovics, I Budai, M Baskin, SI Rockwood, GA Childress, J Budai, L Grof, P Klebovich, I Szilasi, M AF Petrikovics, I. Budai, M. Baskin, S. I. Rockwood, G. A. Childress, J. Budai, L. Grof, P. Klebovich, I. Szilasi, M. TI Characterization of liposomal vesicles encapsulating rhodanese for cyanide antagonism SO DRUG DELIVERY LA English DT Article DE Sterically stabilized liposome; rhodanese; cyanide; size distribution; surface potential; EPR spectroscopy ID STERICALLY STABILIZED LIPOSOMES; SURFACE-MODIFIED LIPOSOMES; BOVINE LIVER RHODANESE; MOLECULAR-INTERACTIONS; HYDROPHILIC POLYMERS; CARRIER ERYTHROCYTES; IN-VITRO; ENZYME; PHOSPHOTRIESTERASE; CIRCULATION AB The major mechanism of removing cyanide from the body is its enzymatic conversion by a sulfurtransferase, e.g. rhodanese, to the less toxic thiocyanate in the presence of a sulfur donor. Earlier results demonstrated that externally administered encapsulated rhodanese significantly enhances the in vivo efficacy of the given sulfur donor. Present studies are focused on liposomal carrier systems encapsulating rhodanese. Physicochemical properties, e.g. membrane rigidity, size distribution, surface potential, osmolarity, and viscosity, were determined for various liposomal lipid compositions and hydrating buffers to establish in vitro stability and in vivo fate. Lipid composition was also optimized to achieve maximum encapsulation efficiency. C1 [Petrikovics, I.; Childress, J.] Sam Houston State Univ, Dept Chem, Huntsville, TX 77341 USA. [Petrikovics, I.; Baskin, S. I.; Rockwood, G. A.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Budai, M.; Grof, P.; Klebovich, I.] Semmelweis Univ, Dept Pharmaceut, H-1085 Budapest, Hungary. [Budai, L.] Hungarian Acad Sci, Inst Struct Chem, Chem Res Ctr, Budapest, Hungary. [Szilasi, M.] Univ Debrecen, Med & Hlth Sci Ctr, Dept Pulmonol, H-4012 Debrecen, Hungary. RP Petrikovics, I (reprint author), Sam Houston State Univ, Dept Chem, Huntsville, TX 77341 USA. EM ixp004@shsu.edu RI Grof, Pal/C-5107-2013 OI Grof, Pal/0000-0002-6488-893X FU NIH: NIAID/USAMRICD Interagency Agreements [Y1-A1-6176-01/02, A120-B.P2006/7-01]; ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE; US Army Research Office Scientific Services Program administered by Battelle [DAAD19-02-D-0001, TCN 06-170, 08284]; Robert A. Welch Foundation [x-0011]; Sam Houston State University, Huntsville, TX FX This study was supported by NIH: NIAID/USAMRICD Interagency Agreements (Y1-A1-6176-01/02 and A120-B.P2006/7-01), and the ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE (Dr Gary Rockwood) under the auspices of the US Army Research Office Scientific Services Program administered by Battelle (Delivery Order 0878, Contract No. DAAD19-02-D-0001, TCN 06-170 and 08284), and the Robert A. Welch Foundation (x-0011) at Sam Houston State University, Huntsville, TX. NR 42 TC 9 Z9 9 U1 0 U2 10 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1071-7544 EI 1521-0464 J9 DRUG DELIV JI Drug Deliv. PD AUG PY 2009 VL 16 IS 6 BP 312 EP 319 DI 10.1080/10717540903003711 PG 8 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 492WC UT WOS:000269692200003 PM 19606945 ER PT J AU Bohannon, AW Hromadka, TV AF Bohannon, A. W. Hromadka, T. V. TI The complex polynomial method with a least-squares fit to boundary conditions SO ENGINEERING ANALYSIS WITH BOUNDARY ELEMENTS LA English DT Article DE Complex polynomial method; Complex variables; Partial differential equations; Boundary value problems; Complex variable boundary element method; Laplace equation AB We present a new application of the complex polynomial method variant of the complex variable boundary element method. instead of fitting the boundary conditions using collocation points, we minimize the error of fit in the l(2) norm to minimize the least-squares error. This approach greatly enhances the utility and efficiency of the method, allowing us to apply the method to a variety of engineering problems. Published by Elsevier Ltd. C1 [Bohannon, A. W.; Hromadka, T. V.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. RP Hromadka, TV (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM addison.bohannon@us.army.mil; theodore.hromadka@usma.edu NR 9 TC 4 Z9 4 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0955-7997 J9 ENG ANAL BOUND ELEM JI Eng. Anal. Bound. Elem. PD AUG-SEP PY 2009 VL 33 IS 8-9 BP 1100 EP 1102 DI 10.1016/j.enganabound.2009.02.005 PG 3 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Mathematics GA 464OP UT WOS:000267515100010 ER PT J AU Wang, X Santare, MH Gazonas, GA AF Wang, Xu Santare, Michael H. Gazonas, George A. TI Anisotropic effective moduli of microcracked materials under antiplane loading SO ENGINEERING FRACTURE MECHANICS LA English DT Article DE Anisotropic damage; Crack orientation distribution function; Effective moduli; Generalized self-consistent method ID ELASTIC-MODULI; CRACKED BODIES; DEFORMATIONS AB This study focuses on the prediction of the anisotropic effective elastic moduli of a solid containing microcracks with an arbitrary degree of alignment by using the generalized self-consistent method (GSCM). The effective elastic moduli pertaining to anti-plane shear deformation are discussed in detail. The undamaged solid can be isotropic as well as anisotropic. When the undamaged solid is isotropic, the GSCM can be realized exactly. When the undamaged solid is anisotropic it is difficult to provide an analytical solution for the crack opening displacement to be used in the GSCM, thus an approximation of the GSCM is pursued in this case. The explicit expressions of coupled nonlinear equations for the unknown effective moduli are obtained. The coupled nonlinear equations are easily solved through iteration. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Wang, Xu; Santare, Michael H.] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. [Wang, Xu; Santare, Michael H.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. [Gazonas, George A.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Santare, MH (reprint author), Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. EM santare@udel.edu RI Santare, Michael/B-1725-2008; OI Gazonas, George/0000-0002-2715-016X FU United States Army Research Laboratory FX The three referees' comments and suggestions on revising the initial manuscript are highly appreciated. This research was supported by the United States Army Research Laboratory through the Composite Materials Technology cooperative agreement with the Center for Composite Materials at the University of Delaware. NR 16 TC 4 Z9 5 U1 1 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0013-7944 J9 ENG FRACT MECH JI Eng. Fract. Mech. PD AUG PY 2009 VL 76 IS 12 BP 1910 EP 1919 DI 10.1016/j.engfracmech.2009.04.010 PG 10 WC Mechanics SC Mechanics GA 477OB UT WOS:000268527300012 ER PT J AU Glinka, YD Shahbazyan, TV Everitt, HO Roberts, J Rajagopal, P Cook, J Piner, E Linthicum, K AF Glinka, Y. D. Shahbazyan, T. V. Everitt, H. O. Roberts, J. Rajagopal, P. Cook, J. Piner, E. Linthicum, K. TI Effect of the surface states on photoluminescence from surface GaN/Al0.2Ga0.8N quantum wells SO EPL LA English DT Article ID BINDING-ENERGY; GAN; EXCITONS; FIELD AB We report on photoluminescence (PL) measurements at 85K for GaN/Al0.2Ga0.8N surface quantum wells (SQWs) with a width in the range of 1.51-2.9 nm. The PL spectra show a redshift with decreasing SQW width, in contrast to the blueshift normally observed for conventional GaN QWs of the same width. The effect is attributed to a strong coupling of SQW confined exciton states with surface acceptors. The PL hence originates from the recombination of surface-acceptor-bound (A(s)(0)X(A)) excitons. Two types of acceptors were identified. Copyright (C) EPLA, 2009 C1 [Glinka, Y. D.] Natl Acad Sci Ukraine, Inst Phys, UA-03028 Kiev, Ukraine. [Glinka, Y. D.; Everitt, H. O.] US Army Aviat & Missile RDEC, Redstone Arsenal, AL 35898 USA. [Shahbazyan, T. V.] Jackson State Univ, Dept Phys, Jackson, MS 39217 USA. [Everitt, H. O.] Duke Univ, Dept Phys, Durham, NC 27708 USA. [Roberts, J.; Rajagopal, P.; Cook, J.; Piner, E.; Linthicum, K.] Nitronex Corp, Raleigh, NC 27703 USA. RP Glinka, YD (reprint author), Natl Acad Sci Ukraine, Inst Phys, UA-03028 Kiev, Ukraine. EM glinka@icnanotox.org RI Everitt, Henry/L-7118-2013; Piner, Edwin/B-5359-2016 OI Everitt, Henry/0000-0002-8141-3768; FU NSF [DMR-0906945, HRD-0833178] FX One of the authors (YDG) gratefully acknowledges support from the U. S. Army Aviation and Missile RDEC. We thank Dr Muth for helpful comments on this work. The work at Jackson State University was supported in part by the NSF under Grants DMR-0906945 and HRD-0833178. NR 20 TC 0 Z9 0 U1 0 U2 3 PU EPL ASSOCIATION, EUROPEAN PHYSICAL SOCIETY PI MULHOUSE PA 6 RUE DES FRERES LUMIERE, MULHOUSE, 68200, FRANCE SN 0295-5075 J9 EPL-EUROPHYS LETT JI EPL PD AUG PY 2009 VL 87 IS 4 AR 47007 DI 10.1209/0295-5075/87/47007 PG 6 WC Physics, Multidisciplinary SC Physics GA 498MZ UT WOS:000270146400022 ER PT J AU Guglielmone, AA Robbins, RG Apanaskevich, DA Petney, TN Estrada-Pena, A Horak, IG AF Guglielmone, Alberto A. Robbins, Richard G. Apanaskevich, Dmitry A. Petney, Trevor N. Estrada-Pena, Agustin Horak, Ivan G. TI Comments on controversial tick (Acari: Ixodida) species names and species described or resurrected from 2003 to 2008 SO EXPERIMENTAL AND APPLIED ACAROLOGY LA English DT Review DE Ixodida; Argasidae; Ixodidae; Species names ID GENUS HYALOMMA KOCH; 16S RDNA SEQUENCES; IXODOIDEA-IXODIDAE; TAXONOMIC STATUS; IMMATURE STAGES; 1ST DESCRIPTION; SOUTH-AMERICA; N. SP; AMBLYOMMA; ARGASIDAE AB There are numerous discrepancies in recent published lists of the ticks of the world. Here we review the controversial names, presenting evidence for or against their validity and excluding some altogether. We also address spelling errors and present a list of 17 species described or resurrected during the years 2003-2008. We consider the following 35 tick species names to be invalid: Argas fischeri Audouin, 1826, Ornithodoros boliviensis Kohls and Clifford, 1964, Ornithodoros steini (Schulze, 1935), Amblyomma acutangulatum Neumann, 1899, Amblyomma arianae Keirans and Garris, 1986, Amblyomma bibroni (Gervais, 1842), Amblyomma colasbelcouri (Santos Dias, 1958), Amblyomma concolor Neumann, 1899, Amblyomma cooperi Nuttall and Warburton, 1908, Amblyomma curruca Schulze, 1936, Amblyomma cyprium Neumann, 1899, Amblyomma decorosum (Koch, 1867), Amblyomma nocens Robinson, 1912, Amblyomma perpunctatum (Packard, 1869), Amblyomma striatum Koch, 1844, Amblyomma superbum Santos Dias, 1953, Amblyomma testudinis (Conil, 1877), Amblyomma trinitatis Turk, 1948, Dermacentor confractus (Schulze 1933), Dermacentor daghestanicus Olenev, 1928, Haemaphysalis himalaya Hoogstraal, 1966, Haemaphysalis vietnamensis Hoogstraal and Wilson, 1966, Hyalomma detritum Schulze, 1919, Ixodes apteridis Maskell, 1897, Ixodes donarthuri Santos Dias, 1980, Ixodes kempi Nuttall, 1913, Ixodes neotomae Cooley, 1944, Ixodes rangtangensis Teng, 1973, Ixodes robertsi Camicas, Hervy, Adam and Morel, 1998, Ixodes serrafreirei Amorim, Gazetta, Bossi and Linhares, 2003, Ixodes tertiarius Scudder, 1885, Ixodes uruguayensis Kohls and Clifford, 1967, Ixodes zealandicus Dumbleton, 1961, Ixodes zumpti Arthur, 1960 and Rhipicephalus camelopardalis Walker and Wiley, 1959. We consider the following 40 names valid: Argas delicatus Neumann, 1910, Argas vulgaris Filippova, 1961, Ornithodoros aragaoi Fonseca, 1960, Ornithodoros dugesi Mazzoti, 1943, Ornithodoros knoxjonesi Jones and Clifford, 1972, Ornithodoros marocanus Velu, 1919, Ornithodoros nattereri Warburton, 1927, Amblyomma beaurepairei Vogelsang and Santos Dias, 1953, Amblyomma crassipes (Neumann, 1901), Amblyomma echidnae Roberts, 1953, Amblyomma fuscum Neumann, 1907, Amblyomma orlovi (Kolonin, 1995), Amblyomma parkeri Fonseca and Arago, 1952, Amblyomma pseudoconcolor Arago, 1908, Bothriocroton oudemansi (Neumann, 1910), Bothriocroton tachyglossi (Roberts, 1953), Dermacentor abaensis Teng, 1963, Dermacentor confragus (Schulze 1933), Dermacentor ushakovae Filippova and Panova, 1987, Haemaphysalis anomaloceraea Teng, 1984, Haemaphysalis filippovae Bolotin, 1979, Haemaphysalis pavlovskyi Pospelova-Shtrom, 1935, Hyalomma excavatum Koch, 1844, Hyalomma isaaci Sharif, 1928, Hyalomma rufipes Koch, 1844, Hyalomma turanicum Pomerantzev, 1946, Ixodes arabukiensis Arthur, 1959, Ixodes boliviensis Neumann, 1904, Ixodes columnae Takada and Fujita, 1992, Ixodes maslovi Emel'yanova and Kozlovskaya, 1967, Ixodes sachalinensis Filippova, 1971, Ixodes siamensis Kitaoka and Suzuki, 1983, Ixodes sigelos Keirans, Clifford and Corwin, 1976, Ixodes succineus Weidner, 1964, Rhipicephalus aurantiacus Neumann, 1907, Rhipicephalus cliffordi Morel, 1965, Rhipicephalus pilans Schulze, 1935, Rhipicephalus pseudolongus Santos Dias, 1953, Rhipicephalus serranoi Santos Dias, 1950 and Rhipicephalus tetracornus Kitaoka and Suzuki, 1983. C1 [Guglielmone, Alberto A.] Inst Nacl Tecnol Agropecuaria, Estac Expt Agropecuaria Rafaela, RA-2300 Rafaela, Santa Fe, Argentina. [Robbins, Richard G.] Walter Reed Army Med Ctr, DPMIAC AFPMB, Washington, DC 20307 USA. [Apanaskevich, Dmitry A.] Georgia So Univ, US Natl Tick Collect, Inst Arthropodol & Parasitol, Statesboro, GA 30460 USA. [Petney, Trevor N.] Inst Zool 1, Abt Okol & Parasitol, D-76131 Karlsruhe, Germany. [Estrada-Pena, Agustin] Univ Zaragoza, Fac Vet, E-50013 Zaragoza, Spain. [Horak, Ivan G.] Univ Pretoria, Fac Vet Sci, Dept Vet Trop Dis, ZA-0110 Onderstepoort, Pretoria, South Africa. RP Guglielmone, AA (reprint author), Inst Nacl Tecnol Agropecuaria, Estac Expt Agropecuaria Rafaela, CC 22, RA-2300 Rafaela, Santa Fe, Argentina. EM aguglielmone@rafaela.inta.gov.ar; richard.robbins@osd.mil; Trevor.petney@t-online.de; aestrada@unizar.es; ivan.horak@up.ac.za OI Estrada Pena, Agustin/0000-0001-7483-046X FU Instituto Nacional de Tecnologia Agropecuaria; Asociacion Cooperadora de la Estacion Experimental Agropecuaria Rafaela del Instituto Nacional de Tecnologia Agropecuaria; Consejo Nacional de Investigaciones Cientificas y Tecnicas, Argentina FX We thank Prof. F. Jongejan, the Coordinator of the Integrated Consortium on Ticks and Tick-borne Diseases 3, for his encouragement, and Prof. R. Melendez for his search of the type of A. beaurepairei. We are grateful to M. Sanchez for her assistance in searching the literature. Thanks also to the Instituto Nacional de Tecnologia Agropecuaria, Asociacion Cooperadora de la Estacion Experimental Agropecuaria Rafaela del Instituto Nacional de Tecnologia Agropecuaria and to the Consejo Nacional de Investigaciones Cientificas y Tecnicas, Argentina, for supporting the research of AAG. NR 100 TC 33 Z9 42 U1 0 U2 12 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0168-8162 J9 EXP APPL ACAROL JI Exp. Appl. Acarol. PD AUG PY 2009 VL 48 IS 4 BP 311 EP 327 DI 10.1007/s10493-009-9246-2 PG 17 WC Entomology SC Entomology GA 461TP UT WOS:000267294700004 PM 19169832 ER PT J AU Nie, X Song, B Ge, Y Chen, WW Weerasooriya, T AF Nie, X. Song, B. Ge, Y. Chen, W. W. Weerasooriya, T. TI Dynamic Tensile Testing of Soft Materials SO EXPERIMENTAL MECHANICS LA English DT Article DE Split Hopkinson tension bar; Impact testing; Dynamic equilibrium; Inertia effects; Soft material ID HOPKINSON PRESSURE BAR; STRAIN-RATE; STRESS; BEHAVIOR; RATES; POLYMERS; INERTIA; RUBBER AB Determination of dynamic tensile response of soft materials has been a challenge because of experimental difficulties. Split Hopkinson tension bar (SHTB) is a commonly used device for the characterization of high-rate tensile behavior of engineering materials. However, when the specimen is soft, it is challenging to design the necessary grips, to measure the weak transmitted signals, and for the specimen to achieve dynamic stress equilibrium. In this work, we modified the SHTB on the loading pulse, the equilibrium-monitoring system, and the specimen geometry. The results obtained using this modified device to characterize a soft rubber indicate that the specimen deforms under dynamic stress equilibrium at a nearly constant strain rate. Axial and radial inertia effects commonly encountered in dynamic characterization of soft materials are also minimized. C1 [Nie, X.; Song, B.; Chen, W. W.] Purdue Univ, Sch Mat Engn, W Lafayette, IN 47907 USA. [Song, B.; Ge, Y.; Chen, W. W.] Purdue Univ, Sch Aeronaut & Astronaut, W Lafayette, IN 47907 USA. [Weerasooriya, T.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Chen, WW (reprint author), Purdue Univ, Sch Mat Engn, W Lafayette, IN 47907 USA. EM xnie@purdue.edu; songb@purdue.edu; yge@purdue.edu; wchen@purdue.edu; tusitw@arl.army.mil RI Ge, Yun/B-7661-2012; Song, Bo/D-3945-2011 FU US Army Research Laboratory (ARL) FX This research was supported by US Army Research Laboratory (ARL) through a collaborative research agreement with Purdue University. NR 30 TC 22 Z9 25 U1 3 U2 23 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0014-4851 EI 1741-2765 J9 EXP MECH JI Exp. Mech. PD AUG PY 2009 VL 49 IS 4 BP 451 EP 458 DI 10.1007/s11340-008-9133-5 PG 8 WC Materials Science, Multidisciplinary; Mechanics; Materials Science, Characterization & Testing SC Materials Science; Mechanics GA 464DO UT WOS:000267485600002 ER PT J AU Jung, CM Heinze, TM Schnackenberg, LK Mullis, LB Elkins, SA Elkins, CA Steele, RS Sutherland, JB AF Jung, Carina M. Heinze, Thomas M. Schnackenberg, Laura K. Mullis, Lisa B. Elkins, Stephanie A. Elkins, Christopher A. Steele, Roger S. Sutherland, John B. TI Interaction of dietary resveratrol with animal-associated bacteria SO FEMS MICROBIOLOGY LETTERS LA English DT Article DE dietary supplements; intestinal bacteria; phytochemicals; resveratrol; stilbenes ID RED WINE; MULTIDRUG-RESISTANCE; PHENOLIC-COMPOUNDS; ESCHERICHIA-COLI; EFFLUX PUMPS; INHIBITORS; IDENTIFICATION; ANTIOXIDANT; EXTRACTS; PROTECTS AB Resveratrol (3,5,4'-trihydroxy-trans-stilbene), an antifungal phytoalexin produced by grapes, peanuts, and Japanese knotweeds, is thought to be a beneficial dietary phytochemical in red wine and grape juice. Information on its antibacterial properties and biotransformation, however, is limited. We surveyed the interactions of resveratrol with 43 strains of bacterial species that are often animal- or human-associated. Resveratrol at 50 mg L(-1) reduced the growth rates of most of the bacteria tested, but did not totally prevent growth even at much higher levels. Eleven of the 43 bacteria were capable of transforming at least 20% of the resveratrol. Three major metabolites were identified as resveratroloside, piceid, and dihydroresveratrol, and three other metabolites were partially characterized. C1 [Mullis, Lisa B.; Elkins, Stephanie A.; Steele, Roger S.; Sutherland, John B.] US FDA, Natl Ctr Toxicol Res, Div Microbiol, Jefferson, AR 72079 USA. [Jung, Carina M.] USA, Engineer Res & Dev Ctr, Vicksburg, MS USA. [Heinze, Thomas M.] US FDA, Natl Ctr Toxicol Res, Div Biochem Toxicol, Jefferson, AR 72079 USA. [Schnackenberg, Laura K.] US FDA, Natl Ctr Toxicol Res, Div Syst Toxicol, Jefferson, AR 72079 USA. [Elkins, Christopher A.] US FDA, Ctr Food Safety & Appl Nutr, Laurel, MD USA. RP Sutherland, JB (reprint author), US FDA, Natl Ctr Toxicol Res, Div Microbiol, 3900 NCTR Rd, Jefferson, AR 72079 USA. EM john.sutherland@fda.hhs.gov NR 39 TC 27 Z9 28 U1 2 U2 11 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0378-1097 J9 FEMS MICROBIOL LETT JI FEMS Microbiol. Lett. PD AUG PY 2009 VL 297 IS 2 BP 266 EP 273 DI 10.1111/j.1574-6968.2009.01691.x PG 8 WC Microbiology SC Microbiology GA 469FT UT WOS:000267882000018 PM 19566680 ER PT J AU Ottinger, MA Lavoie, ET Thompson, N Bohannon, M Dean, K Quinn, MJ AF Ottinger, Mary Ann Lavoie, Emma T. Thompson, Nicola Bohannon, Meredith Dean, Karen Quinn, Michael J., Jr. TI Is the gonadotropin releasing hormone system vulnerable to endocrine disruption in birds? SO GENERAL AND COMPARATIVE ENDOCRINOLOGY LA English DT Article; Proceedings Paper CT 9th International Symposium on Avian Endocrinology CY JUL 11-15, 2008 CL Leuven, BELGIUM DE Birds; Gonadotropin releasing hormone-I; Endocrine disrupting chemicals; Lifetime fitness ID JAPANESE-QUAIL; SEXUAL-DIFFERENTIATION; PESTICIDE METHOXYCHLOR; TRENBOLONE ACETATE; COTURNIX-JAPONICA; I RELEASE; NEUROENDOCRINE; BRAIN; CHEMICALS; CHICKEN AB Endocrine disrupting chemicals (EDCs) from a variety of sources occur widely in the environment, but relationships between exposure to EDCs and long term effects on bird populations can be difficult to prove. Embryonic exposure to EDCs may be particularly detrimental, with potential long-term effects on reproduction and ultimately individual fitness. Because many EDCs may have subtle sublethal effects, it is necessary to establish sensitive end points as biomarkers of EDC exposure in birds. Because the effects of EDCs may be both short- and long-term, it is important to determine if embryonic exposure impacts sexual differentiation and development of the reproductive axis in hatchlings and if there are effects on reproductive function in adults. Our studies have focused on the effects of estrogen- and androgen-active EDCs on the hypothalamic gonadotropin releasing hormone-I (GnRH-I) system in an avian model of precocial species, the Japanese quail. Estrogen- or androgen-active EDCs were administered between 0 and embryonic day 4, and hypothalamic GnRH-I was measured in hatchlings and adults. Treatment with vinclozolin and PCB126 depressed the concentration of embryonic GnRH-I peptide while methoxyclor had an inconsistent stimulatory effect. Treatment with atrazine or trenbolone had no significant effects on hypothalamic GnRH-I in adults. Overall these observations support the view that the developing avian GnRH-I neural system may be vulnerable to EDCs with potential to alter lifelong reproductive function. (C) 2009 Elsevier Inc. All rights reserved. C1 [Ottinger, Mary Ann; Lavoie, Emma T.; Thompson, Nicola; Bohannon, Meredith; Dean, Karen] Univ Maryland, Dept Anim & Avian Sci, College Pk, MD 20742 USA. [Quinn, Michael J., Jr.] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. RP Ottinger, MA (reprint author), Univ Maryland, Dept Anim & Avian Sci, College Pk, MD 20742 USA. EM maottinger@umresearch.umd.edu NR 50 TC 12 Z9 12 U1 2 U2 22 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0016-6480 J9 GEN COMP ENDOCR JI Gen. Comp. Endocrinol. PD AUG-SEP PY 2009 VL 163 IS 1-2 BP 104 EP 108 DI 10.1016/j.ygcen.2009.05.007 PG 5 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 473NG UT WOS:000268213200018 PM 19457435 ER PT J AU Beck, HP McKinney, JB Dzindolet, MT Pierce, LG AF Beck, Hall P. McKinney, J. Bates Dzindolet, Mary T. Pierce, Linda G. TI Effects of Human-Machine Competition on Intent Errors in a Target Detection Task SO HUMAN FACTORS LA English DT Article ID AUTOMATION USAGE DECISIONS; TRUST; SYSTEMS; INFORMATION; MISUSE; DISUSE; AIDS; RELIABILITY; STRATEGIES; ALLOCATION AB Objective: This investigation examined the impact of human-machine competition (John Henry effects) on intent errors. John Henry effects, expressed as an unwillingness to use automation, were hypothesized to increase as a function of operators' personal investment in unaided performance. Background: Misuse and disuse often occur because operators (a) cannot determine if automation or a nonautomated alternative maximizes the likelihood of task success (appraisal errors) or (b) know the utilities of the options but disregard this information when deciding to use or not to use automation (intent errors). Although appraisal errors have been extensively studied, there is a paucity of information regarding the causes and prevention of intent errors. Methods: Operators were told how many errors they and an automated device made on a target detection task. Self-reliant operators (high personal investment) could depend on their performance or automation to identify a target. Other-reliant operators (low personal investment) could rely on another person or automation. Results: As predicted, self-reliance increased disuse and decreased misuse. Conclusion: When the disuse and misuse data are viewed together, they strongly support the supposition that personal investment in unaided performance affects the likelihood of John Henry effects and intent errors. Application: These results demonstrate the need for a model of operator decision making that takes into account intent as well as appraisal errors. Potential applications include developing interventions to counter the deleterious effects of human-machine competition and intent errors on automation usage decisions. C1 [Beck, Hall P.] Appalachian State Univ, Dept Psychol, Boone, NC 28608 USA. [McKinney, J. Bates] Univ S Carolina Upstate, Spartanburg, SC USA. [Dzindolet, Mary T.] Cameron Univ, Dept Psychol & Human Ecol, Lawton, OK 73505 USA. [Pierce, Linda G.] USA, Res Inst Behav & Social Sci, Org Performance Res Unit, Aberdeen, MD USA. RP Beck, HP (reprint author), Appalachian State Univ, Dept Psychol, 222 Joyce Lawrence Lane, Boone, NC 28608 USA. EM beckhp@appstate.edu NR 38 TC 5 Z9 5 U1 2 U2 5 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0018-7208 J9 HUM FACTORS JI Hum. Factors PD AUG PY 2009 VL 51 IS 4 BP 477 EP 486 DI 10.1177/0018720809341746 PG 10 WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Behavioral Sciences; Engineering; Psychology GA 501AY UT WOS:000270351000004 PM 19899358 ER PT J AU Shen, Y Guturu, P Damarla, T Buckles, BP Namudari, KR AF Shen, Yao Guturu, Parthasarathy Damarla, Thyagaraju Buckles, Bill P. Namudari, Kameswara Rao TI Video Stabilization Using Principal Component Analysis and Scale Invariant Feature Transform in Particle Filter Framework SO IEEE TRANSACTIONS ON CONSUMER ELECTRONICS LA English DT Article DE Digital video stabilization; principal component analysis (PCA); scale invariant feature transform (SIFT); PCA-SIFT; RANSAC; particle filter AB This paper presents a novel approach to digital video stabilization that uses adaptive particle filter for global motion estimation. In this approach, dimensionality of the feature space is first reduced by the principal component analysis (PCA) method using the features obtained from a scale invariant feature tran, form (SIFT), and hence the resultant features may be termed as the PCA-SIFT features. The trajectory, of these features extracted from video frames is used to estimate undesirable motion between frames. A new cost function called SIFT-BMSE (SIFT Block Mean Square Error) is proposed in adaptive particle filter framework to disregard the foreground object pixels and reduce the computational cost. Frame compensation based on these estimates yields stabilized full-frame video sequences. Experimental results show, that the proposed algorithm is both accurate and efficient(1). C1 [Shen, Yao; Buckles, Bill P.] Univ N Texas, Dept Comp Sci & Engn, Denton, TX 76207 USA. [Guturu, Parthasarathy; Namudari, Kameswara Rao] Univ N Texas, Dept Elect Engn, Denton, TX 76207 USA. [Damarla, Thyagaraju] USA, Res Lab, Adelphi, MD 20783 USA. RP Shen, Y (reprint author), Univ N Texas, Dept Comp Sci & Engn, Denton, TX 76207 USA. EM guturu@unt.edu; rdamarla@arl.army.mil; bbuckles@cse.unt.edu; kamesh.namuduri@unt.edu FU Army Research Lab, Adelphi, MD, USA [W911NF-06-2-0037]; Provost, University of North Texas FX Authors gratefully acknowledge the support for this work from second author's grant W911NF-06-2-0037 from the Army Research Lab, Adelphi, MD, USA, and the first author's research scholarship from the Provost, University of North Texas. NR 14 TC 23 Z9 33 U1 4 U2 8 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0098-3063 J9 IEEE T CONSUM ELECTR JI IEEE Trans. Consum. Electron. PD AUG PY 2009 VL 55 IS 3 BP 1714 EP 1721 PG 8 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 501DB UT WOS:000270358500104 ER PT J AU Ahmad, FH Castellane, RM Durst, BP Fairley, JR AF Ahmad, Falih H. Castellane, Ray M. Durst, Bartley P. Fairley, Josh R. TI Technique for the Evaluation of Chirality, Permittivity, and Permeability of a Reciprocal Chiral Slab Through the Utilization of the Time-Harmonic Green Functions SO IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT LA English DT Article; Proceedings Paper CT IEEE International Symposium on Intelligent Signal Processing CY OCT 03-05, 2007 CL Alcala de Henares, SPAIN SP IEEE, IEEE Instrumentat & Measurement Soc, IEEE Secc Espana, Univ Alcala, Dept Elect DE Chiral media; composite media; electromagnetic numerical methods; electromagnetic properties; electromagnetic scattering; reciprocal wave propagation ID ELECTROMAGNETIC-WAVES; SCATTERING; MEDIA AB In this paper, a technique is developed to compute values of the chirality, permittivity, and permeability of a dielectric reciprocal chiral slab from the knowledge of limited laboratory measurement information. The chirality parameter is a function of frequency and depth of the slab. The developed technique is based on the use of coupled differential equations for the Green functions associated with electromagnetic propagation through the slab. The technique makes use of the Nth degree interpolation polynomials to approximate the Green functions and the chiral parameter among other functions using Legendre-Gauss-Lobatto collocation points. Numerical results from a laboratory measurement simulation are given to demonstrate the validity of the proposed technique. C1 [Ahmad, Falih H.] Tarleton State Univ, Dept Math Phys & Engn, Stephenville, TX 76402 USA. [Castellane, Ray M.; Durst, Bartley P.; Fairley, Josh R.] USA, Waterways Expt Stn, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Ahmad, FH (reprint author), Tarleton State Univ, Dept Math Phys & Engn, Stephenville, TX 76402 USA. EM ahmad@tarleton.edu NR 20 TC 0 Z9 0 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9456 J9 IEEE T INSTRUM MEAS JI IEEE Trans. Instrum. Meas. PD AUG PY 2009 VL 58 IS 8 BP 2518 EP 2524 DI 10.1109/TIM.2009.2014621 PG 7 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 471CT UT WOS:000268033000018 ER PT J AU Valyrakis, A Tsakonas, EE Sidiropoulos, ND Swami, A AF Valyrakis, Alexandros Tsakonas, Efthimios E. Sidiropoulos, Nicholas D. Swami, Ananthram TI Stochastic Modeling and Particle Filtering Algorithms for Tracking a Frequency-Hopped Signal SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article; Proceedings Paper CT 2nd IEEE International Workshop on Computational Advances in Multi-Sensor Adaptive Processing CY DEC 12-14, 2007 CL St Thomas, VI SP IEEE DE Frequency hopping; particle filtering; random hop timing; synchronization; timing jitter; tracking ID STATE ESTIMATION; RESOLUTION AB The problem of tracking a frequency-hopped signal without knowledge of its hopping pattern is considered. The problem is of interest in military communications, where, in addition to frequency, hop timing can also be randomly shifted to guard against unauthorized reception and jamming. A conceptually simple nonlinear and non-Gaussian stochastic state-space model is proposed to capture the randomness in carrier frequency and hop timing. This model is well-suited for the application of particle filtering tools: it is possible to compute the optimal (weight variance-minimizing) importance function in closed-form. A convenient mixture representation of the latter is employed together with Rao-Blackwellization to derive a very simple optimal sampling procedure. This is representative of the state-of-art in terms of systematic design of particle filters. A heuristic design approach is also developed, using the mode of the spectrogrant to localize hop particles. Performance is assessed in a range of experiments using both simulated and measured data. Interestingly, the results indicate that the heuristic design approach can outperform the systematic one, and both are robust to model assumptions. C1 [Valyrakis, Alexandros; Tsakonas, Efthimios E.; Sidiropoulos, Nicholas D.] Tech Univ Crete, Dept Elect & Comp Engn, Khania 73100, Greece. [Swami, Ananthram] USA, Res Lab, Adelphi, MD 20783 USA. RP Valyrakis, A (reprint author), Tech Univ Crete, Dept Elect & Comp Engn, Khania 73100, Greece. EM alevali@telecom.tuc.gr; et-sakwnas@gmail.com; nikos@telecom.tuc.gr; a.swami@ieee.org NR 16 TC 8 Z9 14 U1 2 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1053-587X J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD AUG PY 2009 VL 57 IS 8 BP 3108 EP 3118 DI 10.1109/TSP.2009.2020765 PG 11 WC Engineering, Electrical & Electronic SC Engineering GA 472CL UT WOS:000268106700020 ER PT J AU Mcnutt, PM Mesngon, MT AF Mcnutt, P. M. Mesngon, M. T. TI Development and Characterization of Embryonic Stem Cell-derived Neurons as a Botulinum Inhibitor Drug Discovery Platform SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL LA English DT Meeting Abstract C1 [Mcnutt, P. M.; Mesngon, M. T.] USA, Med Res Inst Chem Def, APG EA, Aberdeen Proving Ground, MD 21010 USA. EM patrick.mcnutt@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1071-2690 J9 IN VITRO CELL DEV-AN JI In Vitro Cell. Dev. Biol.-Anim. PD AUG PY 2009 VL 45 IS 7 BP 407 EP 407 PG 1 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA 474RA UT WOS:000268300500018 ER PT J AU Milhorn, DM Adkins, A Swartz, A Nelson, M AF Milhorn, Denise M. Adkins, Angie Swartz, Adam Nelson, Marian TI Modulation of Inflammatory Mediators in Corneal Tissue Models in Response to Sulfur Mustard Exposure SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL LA English DT Meeting Abstract C1 [Milhorn, Denise M.; Adkins, Angie; Swartz, Adam; Nelson, Marian] USA, Med Res Inst Chem Def, Cellular & Mol Biol Branch, Div Res, Aberdeen Proving Ground, MD 21010 USA. EM denise.milhorn@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1071-2690 J9 IN VITRO CELL DEV-AN JI In Vitro Cell. Dev. Biol.-Anim. PD AUG PY 2009 VL 45 IS 7 BP 407 EP 407 PG 1 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA 474RA UT WOS:000268300500017 ER PT J AU Santacroce, R Soto, L Tollefson, E AF Santacroce, Rudy Soto, Leticia Tollefson, Eric TI IRAQ'S FLOW SO INDUSTRIAL ENGINEER LA English DT Article C1 [Santacroce, Rudy; Soto, Leticia; Tollefson, Eric] Multinatl Corps Iraq, Baghdad, Iraq. [Santacroce, Rudy] US Army Reserve, Ft Gillem, GA USA. [Santacroce, Rudy] Univ Florida, Dept Ind Engn, Gainesville, FL 32611 USA. [Soto, Leticia] USN, Panama City, FL USA. [Tollefson, Eric] USA, Panama City, FL USA. [Tollefson, Eric] USMA, Dept Syst Engn, West Point, NY USA. RP Santacroce, R (reprint author), Multinatl Corps Iraq, Baghdad, Iraq. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INST INDUSTRIAL ENGINEERS PI NORCROSS PA 3577 PARKWAY LANE, STE 200, NORCROSS, GA 30092 USA SN 1542-894X J9 IND ENG JI Ind. Eng PD AUG PY 2009 VL 41 IS 8 BP 24 EP 29 PG 6 WC Engineering, Industrial SC Engineering GA V18MS UT WOS:000208009500016 ER PT J AU Dainty, LA Krivak, TC Webb, JC Zahn, CM Elkas, JC Chernofsky, MR Rose, GS Maxwell, GL AF Dainty, Louis A. Krivak, Thomas C. Webb, Joel C. Zahn, Christopher M. Elkas, John C. Chernofsky, Mildred R. Rose, G. Scott Maxwell, G. Larry TI Diffuse Laminar Endocervical Glandular Hyperplasia A Case Report SO INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER LA English DT Article DE Endocervical glands; Endocervical hyperplasia; Uterine cervix; Pseudoneoplastic lesions ID UTERINE CERVIX; LESIONS; ADENOCARCINOMA AB Background: Diffuse laminar endocervical glandular hyperplasia is extremely rare with only 14 cases reported in the literature. Diffuse laminar endocervical glandular hyperplasia is a benign lesion that is easily confused with malignancy. Case Report: We present a 22-year-old woman referred to our gynecologic oncology service with a 2.0 x 4.0-cm exophytic cervical mass. Colposcopic-directed cervical biopsies were diagnosed as adenocarcinoma, suggestive of minimal deviation adenocarcinoma. Computed tomographic scans of the abdomen and the pelvis failed to reveal any metastatic foci. A radical abdominal hysterectomy with pelvic and para-aortic lymph node sampling was performed without complications. Final pathology revealed diffuse laminar endocervical glandular hyperplasia. Conclusions: Diffuse laminar endocervical glandular hyperplasia is an uncommon histological type of pseudoneoplastic glandular lesions that may be found in the cervix, and this entity Should be considered in the differential diagnosis of a potentially malignant endocervical glandular lesion. C1 [Dainty, Louis A.; Krivak, Thomas C.; Webb, Joel C.; Zahn, Christopher M.; Elkas, John C.; Chernofsky, Mildred R.; Rose, G. Scott; Maxwell, G. Larry] Walter Reed Army Med Ctr, Div Gynecol Oncol, Washington, DC 20307 USA. [Dainty, Louis A.; Krivak, Thomas C.; Webb, Joel C.; Zahn, Christopher M.; Elkas, John C.; Chernofsky, Mildred R.; Rose, G. Scott; Maxwell, G. Larry] Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA. RP Dainty, LA (reprint author), Madigan Army Med Ctr, Dept Obstet & Gynecol, Ft Lewis, WA 98431 USA. EM louis.daintyl@us.army.mil NR 8 TC 2 Z9 5 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1048-891X J9 INT J GYNECOL CANCER JI Int. J. Gynecol. Cancer PD AUG PY 2009 VL 19 IS 6 BP 1091 EP 1093 DI 10.1111/IGC.0b013e3181a839d3 PG 3 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 484HO UT WOS:000269035200018 PM 19820374 ER PT J AU Aungst, MJ Mamienski, TD Albright, TS Zahn, CM Fischer, JR AF Aungst, Matthew J. Mamienski, Thaddeus D. Albright, Todd S. Zahn, Christopher M. Fischer, John R. TI Prophylactic Burch colposuspension at the time of abdominal sacrocolpopexy: a survey of current practice patterns SO INTERNATIONAL UROGYNECOLOGY JOURNAL LA English DT Article CT Annual Meeting of the Armed Forces District of the American-College-of-Obstetricians-and-Gynecologists CY OCT 12-15, 2008 CL Norfolk, VA SP Amer Coll Obstetricians & Gynecologists, Armed Forces Dist DE Occult incontinence; Sacrocolpopexy; Survey; Urogenital surgical procedures/methods ID FREE VAGINAL TAPE; STRESS URINARY-INCONTINENCE; GENITAL PROLAPSE; GENITOURINARY PROLAPSE; CONTINENT WOMEN; FOLLOW-UP; REPAIR; SURGERY; TRIAL AB The purpose of this study was to determine the utilization of the prophylactic Burch procedure with abdominal sacrocolpopexy since the publication of the Colpopexy and Urinary Reduction Efforts (CARE) trial. Using an Internet survey, 1,134 members of the American Urogynecological Society (AUGS) were contacted in May 2008 and questioned regarding their practice patterns to prevent de novo stress incontinence after sacrocolpopexy. Two hundred sixty-six responses were obtained for a 23% response rate. Of the 235 respondents actively performing sacrocolpopexies, 133 (57%) would not perform a prophylactic Burch colposuspension at the time of sacrocolpopexy in a woman without symptoms of stress urinary incontinence. Respondents were more likely to perform a prophylactic Burch if it had been more than 6 years since they completed residency or fellowship training. Prophylactic Burch colposuspension at the time of abdominal sacrocolpopexy has not been uniformly implemented into clinical practice by AUGS members since the publication of the CARE Trial. C1 [Aungst, Matthew J.; Mamienski, Thaddeus D.; Albright, Todd S.; Zahn, Christopher M.; Fischer, John R.] Walter Reed Army Med Ctr, Div Female Pelv Med & Reconstruct Surg, Dept Obstet & Gynecol, Washington, DC 20307 USA. RP Aungst, MJ (reprint author), Walter Reed Army Med Ctr, Div Female Pelv Med & Reconstruct Surg, Dept Obstet & Gynecol, Bldg 2,Room 2J06,6900 Georgia Ave, Washington, DC 20307 USA. EM Matt.Aungst@yahoo.com NR 24 TC 3 Z9 4 U1 0 U2 0 PU SPRINGER LONDON LTD PI ARTINGTON PA ASHBOURNE HOUSE, THE GUILDWAY, OLD PORTSMOUTH ROAD, ARTINGTON GU3 1LP, GUILDFORD, ENGLAND SN 0937-3462 J9 INT UROGYNECOL J JI Int. Urogynecol. J. PD AUG PY 2009 VL 20 IS 8 BP 897 EP 904 DI 10.1007/s00192-009-0881-2 PG 8 WC Obstetrics & Gynecology; Urology & Nephrology SC Obstetrics & Gynecology; Urology & Nephrology GA 467ZR UT WOS:000267783300003 PM 19582381 ER PT J AU Eller, MA Eller, LA Ouma, BJ Thelian, D Gonzalez, VD Guwatudde, D McCutchan, FE Marovich, MA Michael, NL de Souza, MS Wabwire-Mangen, F Robb, ML Currier, JR Sandberg, JK AF Eller, Michael A. Eller, Leigh Anne Ouma, Benson J. Thelian, Doris Gonzalez, Veronica D. Guwatudde, David McCutchan, Francine E. Marovich, Mary A. Michael, Nelson L. de Souza, Mark S. Wabwire-Mangen, Fred Robb, Merlin L. Currier, Jeffrey R. Sandberg, Johan K. TI Elevated Natural Killer Cell Activity Despite Altered Functional and Phenotypic Profile in Ugandans With HIV-1 Clade A or Clade D Infection SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE CD4; HIV-1; NK cells; viral infections ID NK-CELLS; HIV-1-INFECTED PATIENTS; CYTOLYTIC FUNCTION; INNATE IMMUNITY; RAKAI DISTRICT; IMMUNODEFICIENCY; VIRUS; EXPRESSION; CYTOTOXICITY; INDIVIDUALS AB Background and Objective: Natural killer (NK) cells most likely contribute toward limiting HIV-1 replication, and investigation into their function throughout the course of infection is therefore important. We here aimed to determine the state of the NK cell compartment in Ugandans with untreated HIV-1 clade A or D infection in comparison with matched uninfected controls. Methods and Results: The function and phenotype of NK cells were investigated using 10-color flow cytometry. Surprisingly, NK cells displayed elevated production of interferon-gamma and macrophage inflammatory protein 1 beta, as well as CD107a degranulation in infected subjects. This included unexpected levels of degranulation in the CD56bright subset of NK cells and high levels of macrophage inflammatory protein 1 beta in CD56negative NK cells. HIV-1 infection was associated with reduced expression of KIR2DL1, NKG2A, CD161, and NKp30 in CD56dim and CD56negative NK cells, whereas lowered CD161 expression was the only alteration in the CD56bright subset. Interestingly, low CD4 counts were associated with increased levels of interferon-gamma and degranulation in CD56bright NK cells, as well as increased NKp44 expression in the CD56dim cells. Conclusions: NK cells in HIV-1-infected Ugandans display elevated activity, despite an altered functional and phenotypic profile. Furthermore, specific alterations in the CD56bright and CD56dim subsets occur in patients with severe CD4 loss. C1 [Eller, Michael A.] Makerere Univ, Sch Med, Walter Reed Project, Kampala, Uganda. [Eller, Michael A.; Gonzalez, Veronica D.; Sandberg, Johan K.] Karolinska Inst, Karolinska Univ Hosp Huddinge, Dept Med, Ctr Infect Med, Stockholm, Sweden. [Eller, Michael A.; Eller, Leigh Anne; Thelian, Doris; McCutchan, Francine E.; Marovich, Mary A.; Michael, Nelson L.; Robb, Merlin L.; Currier, Jeffrey R.] US Mil HIV Res Program, Rockville, MD USA. [Guwatudde, David; Wabwire-Mangen, Fred] Makerere Univ, Sch Publ Hlth, Kampala, Uganda. [de Souza, Mark S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Eller, MA (reprint author), Makerere Univ, Sch Med, Walter Reed Project, Pathol Bldg A-10,Old Mulago Hill Rd,POB 16524, Kampala, Uganda. EM meller@muwrp.org FU US Army Medical Research and Materiel Command and its Cooperative Agreement [W81XWH-04-02-0005)]; Henry M. Jackson Foundation for the Advancement of Military Medicine; Inter Agency Agreement [IY-Al-26-42-07]; Division of Acquired Immunodeficiency Syndrome (DAIDS); National Institute of Allergy and Infectious Disease (NIAID); National Institutes of Health (NIH).; Swedish Research Council,; Swedish International Development Agency; Swedish Foundation for Strategic Research,; Swedish National Board of Health and Welfare FX Supported in part by the US Army Medical Research and Materiel Command and its Cooperative Agreement (W81XWH-04-02-0005) with the Henry M. Jackson Foundation for the Advancement of Military Medicine and with an Inter Agency Agreement (IY-Al-26-42-07) with Division of Acquired Immunodeficiency Syndrome (DAIDS), National Institute of Allergy and Infectious Disease (NIAID), and National Institutes of Health (NIH). Additional work was supported in part by grants from the Swedish Research Council, the Swedish International Development Agency, the Swedish Foundation for Strategic Research, and the Swedish National Board of Health and Welfare. NR 47 TC 26 Z9 29 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD AUG 1 PY 2009 VL 51 IS 4 BP 380 EP 389 PG 10 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 470RJ UT WOS:000267997100003 PM 19487954 ER PT J AU Gonzalez, RR Cheuvront, SN Montain, SJ Goodman, DA Blanchard, LA Berglund, LG Sawka, MN AF Gonzalez, R. R. Cheuvront, S. N. Montain, S. J. Goodman, D. A. Blanchard, L. A. Berglund, L. G. Sawka, M. N. TI Expanded prediction equations of human sweat loss and water needs SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE thermoregulation; modeling; fluid balance; hydration; fluid replacement ID FLUID REPLACEMENT; EXERCISE; HEAT; RESPONSES; PERFORMANCE; EVAPORATION; HYDRATION; STRAIN; TIME AB Gonzalez RR, Cheuvront SN, Montain SJ, Goodman DA, Blanchard LA, Berglund LG, Sawka MN. Expanded prediction equations of human sweat loss and water needs. J Appl Physiol 107: 379-388, 2009. First published April 30, 2009; doi: 10.1152/japplphysiol.00089.2009.-The Institute of Medicine expressed a need for improved sweating rate ((m)overdot(sw)) prediction models that calculate hourly and daily water needs based on metabolic rate, clothing, and environment. More than 25 years ago, the original Shapiro prediction equation (OSE) was formulated as (m)overdot(sw) (g.m(-2).h(-1)) = 27.9.E(req). (E(max))(-0.455), where E(req) is required evaporative heat loss and Emax is maximum evaporative power of the environment; OSE was developed for a limited set of environments, exposures times, and clothing systems. Recent evidence shows that OSE often overpredicts fluid needs. Our study developed a corrected OSE and a new (m)overdot(sw) prediction equation by using independent data sets from a wide range of environmental conditions, metabolic rates (rest to <= 450 W/m(2)), and variable exercise durations. Whole body sweat losses were carefully measured in 101 volunteers (80 males and 21 females; > 500 observations) by using a variety of metabolic rates over a range of environmental conditions (ambient temperature, 1546 degrees C; water vapor pressure, 0.27-4.45 kPa; wind speed, 0.4-2.5 m/s), clothing, and equipment combinations and durations (2-8 h). Data are expressed as grams per square meter per hour and were analyzed using fuzzy piecewise regression. OSE overpredicted sweating rates (P < 0.003) compared with observed (m)overdot(sw). Both the correction equation (OSE(C)), (m)overdot(sw) = 147 . exp (0.0012 . OSE), and a new piecewise (PW) equation, (m)overdot(sw) = 147 + 1.527.E(req) - 0.87.E(max) were derived, compared with OSE, and then cross-validated against independent data (21 males and 9 females; > 200 observations). OSEC and PW were more accurate predictors of sweating rate (58 and 65% more accurate, P < 0.01) and produced minimal error (standard error estimate < 100 g.m(-2).h(-1)) for conditions both within and outside the original OSE domain of validity. The new equations provide for more accurate sweat predictions over a broader range of conditions with applications to public health, military, occupational, and sports medicine settings. C1 [Cheuvront, S. N.] USA, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA. [Gonzalez, R. R.] New Mexico State Univ, Dept Biol, Las Cruces, NM 88003 USA. RP Cheuvront, SN (reprint author), USA, Thermal & Mt Med Div, Environm Med Res Inst, Kansas St, Natick, MA 01760 USA. EM samuel.n.cheuvront@us.army.mil FU U. S. Army Medical Research and Materiel Command FX This work was funded by several research grants and contracts from U. S. Army Medical Research and Materiel Command. NR 31 TC 30 Z9 31 U1 0 U2 9 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD AUG PY 2009 VL 107 IS 2 BP 379 EP 388 DI 10.1152/japplphysiol.00089.2009 PG 10 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 477EA UT WOS:000268500200003 PM 19407259 ER PT J AU Trudel, G Payne, M Madler, B Ramachandran, N Lecompte, M Wade, C Biolo, G Blanc, S Hughson, R Bear, L Uhthoff, HK AF Trudel, Guy Payne, Michael Maedler, Burkhard Ramachandran, Nanthan Lecompte, Martin Wade, Charles Biolo, Gianni Blanc, Stephane Hughson, Richard Bear, Lisa Uhthoff, Hans K. TI Bone marrow fat accumulation after 60 days of bed rest persisted 1 year after activities were resumed along with hemopoietic stimulation: the Women International Space Simulation for Exploration study SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE magnetic resonance imaging; erythropoietin; erythrocytes; leukocytes ID PROTON MR SPECTROSCOPY; IN-VIVO; MYELOID-LEUKEMIA; STROMAL CELLS; GROWTH-FACTOR; STEM-CELL; OSTEOPOROSIS; LEPTIN; TISSUE; RECEPTOR AB Trudel G, Payne M, Madler B, Ramachandran N, Lecompte M, Wade C, Biolo G, Blanc S, Hughson R, Bear L, Uhthoff HK. Bone marrow fat accumulation after 60 days of bed rest persisted 1 year after activities were resumed along with hemopoietic stimulation: the Women International Space Simulation for Exploration study. J Appl Physiol 107: 540-548, 2009. First published May 28, 2009; doi: 10.1152/japplphysiol.91530.2008.-Immobility in bed and decreased mobility cause adaptations to most human body systems. The effect of immobility on fat accumulation in hemopoietic bone marrow has never been measured prospectively. The reversibility of marrow fat accumulation and the effects on hemopoiesis are not known. In the present study, 24 healthy women (age: 25-40 yr) underwent -6 degrees head-down bed rest for 60 days. We used MRI to noninvasively measure the lumbar vertebral fat fraction at various time points. We also measured hemoglobin, erythropoietin, reticulocytes, leukocytes, platelet count, peripheral fat mass, leptin, cortisol, and C-reactive protein during bed rest and for 1 yr after bed rest ended. Compared with baseline, the mean (+/- SE) fat fraction was increased after 60 days of bed rest (+2.5 +/- 1.1%, P < 0.05); the increase persisted 1 yr after the resumption of regular activities (+2.3 +/- 0.8%, P < 0.05). Mean hemoglobin levels were significantly decreased 6 days after bed rest ended (-1.36 +/- 0.20 g/dl, P < 0.05) but had recovered at 1 yr, with significantly lower mean circulating erythropoietin levels (-3.8 +/- 1.2 mU/ml, P < 0.05). Mean numbers of neutrophils and lymphocytes remained significantly elevated at 1 yr (+617 +/- 218 neutrophils/mu l and +498 +/- 112 lymphocytes/mu l, both P < 0.05). These results constitute direct evidence that bed rest irreversibly accelerated fat accumulation in hemopoietic bone marrow. The 2.5% increase in fat fraction after 60 days of bed rest was 25-fold larger than expected from historical ambulatory controls. Sixty days of bed rest accelerated by 4 yr the normal bone marrow involution. Bed rest and marrow adiposity were associated with hemopoietic stimulation. One year after subjects returned to normal activities, hemoglobin levels were maintained, with 43% lower circulating erythropoietin levels, and leukocytes remained significantly elevated across lineages. Lack of mobility alters hemopoiesis, possibly through marrow fat accumulation, with potentially wide-ranging clinical consequences. C1 [Trudel, Guy; Payne, Michael; Ramachandran, Nanthan; Lecompte, Martin; Uhthoff, Hans K.] Univ Ottawa, Bone & Joint Lab, Ottawa, ON K1H 8M2, Canada. [Maedler, Burkhard] Univ British Columbia, Dept Phys & Astron, Vancouver, BC V5Z 1M9, Canada. [Wade, Charles; Bear, Lisa] USA, Inst Surg Res, Houston, TX USA. [Biolo, Gianni] Univ Trieste, Dept Clin Morphol & Technol Sci, Trieste, Italy. [Blanc, Stephane] Dept Ecol Physiol & Ethol, Strasbourg, France. [Hughson, Richard] Univ Waterloo, Cardioresp & Vasc Dynam Lab, Waterloo, ON N2L 3G1, Canada. RP Trudel, G (reprint author), Univ Ottawa, Ottawa Hosp, Bone & Joint Lab, Rehabil Ctr, 505 Smyth Rd, Ottawa, ON K1H 8M2, Canada. EM gtrudel@ottawahospital.on.ca OI BIOLO, GIANNI/0000-0002-6397-1598 FU Canadian Institutes of Health [BRS 67811]; European Space Agency; United States National Aeronautics and Space Administration; Canadian Space Agency; French "Centre National d'Etudes Spatiales," FX This study was supported by Canadian Institutes of Health Research Grant BRS 67811. Women International Space Simulation for Exploration 2005 was sponsored by the European Space Agency, the United States National Aeronautics and Space Administration, the Canadian Space Agency, and the French "Centre National d'Etudes Spatiales," which was the "Promoteur" of the study according to French law. This study was performed by the Institute for Space Physiology and Medicine ( Toulouse, France). NR 58 TC 44 Z9 44 U1 1 U2 5 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD AUG PY 2009 VL 107 IS 2 BP 540 EP 548 DI 10.1152/japplphysiol.91530.2008 PG 9 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 477EA UT WOS:000268500200023 PM 19478189 ER PT J AU Freccero, DM Providence, B Berkowitz, MJ Lee, GY AF Freccero, David M. Providence, Bertram Berkowitz, Mark J. Lee, Gregory Y. TI Postoperative Assessment of Vascularity of the Femoral Head After Surgical Hip Dislocation SO JOURNAL OF ARTHROPLASTY LA English DT Article DE femoroacetabular impingement; hip avascular necrosis ID FEMOROACETABULAR IMPINGEMENT; AVASCULAR NECROSIS AB Treatment for femoroacetabular impingement includes surgical hip dislocation and recontouring the femoral head-neck junction. However, a potential complication of this procedure is avascular necrosis. The purpose of this study was to assess radiographically the vascularity of the femoral head after surgical hit) dislocation. Ten patients underwent surgical hip dislocation and recontouring of the femoral head-neck junction for femoroacetabular impingement. Postoperatively, all 10 patients underwent magnetic resonance imaging of the hip. Magnetic resonance imaging revealed no evidence of osteonecrosis in all patients. This Study provides clear radiographic evidence that. surgical hip dislocation may be performed without causing avascular necrosis of the femoral head. C1 [Freccero, David M.; Berkowitz, Mark J.; Lee, Gregory Y.] Tripler Army Med Ctr, Orthopaed Surg Serv, Honolulu, HI 96859 USA. [Providence, Bertram] Walter Reed Army Med Ctr, Dept Orthopaed Surg & Rehabil, Washington, DC 20307 USA. NR 15 TC 4 Z9 5 U1 0 U2 1 PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS PI PHILADELPHIA PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA SN 0883-5403 J9 J ARTHROPLASTY JI J. Arthroplast. PD AUG PY 2009 VL 24 IS 5 BP 689 EP 692 DI 10.1016/j.arth.2008.06.005 PG 4 WC Orthopedics SC Orthopedics GA 489FA UT WOS:000269404200005 PM 18757173 ER PT J AU Liljegren, JC Tschopp, S Rogers, K Wasmer, F Liljegren, L Myirski, M AF Liljegren, James C. Tschopp, Stephen Rogers, Kevin Wasmer, Fred Liljegren, Lucia Myirski, Michael TI Quality Control of Meteorological Data for the Chemical Stockpile Emergency Preparedness Program SO JOURNAL OF ATMOSPHERIC AND OCEANIC TECHNOLOGY LA English DT Article ID SINGLE-PASS ESTIMATORS; STANDARD-DEVIATION; WIND DIRECTION; OKLAHOMA MESONET; ASSURANCE; ROUTINE AB The Chemical Stockpile Emergency Preparedness Program Meteorological Support Project ensures the accuracy and reliability of data acquired by meteorological monitoring stations located at seven U. S. Army chemical weapons depots where storage and weapons destruction ( demilitarization) activities are ongoing. The data are delivered in real time to U. S. Army plume dispersion models, which are used to plan for and respond to a potential accidental release of a chemical weapons agent. The project provides maintenance, calibration, and audit services for the instrumentation; collection, automated screening, visual inspection, and analysis of the data; and problem reporting and tracking to carefully control the data quality. The resulting high-quality meteorological data enhance emergency response modeling and public safety. C1 [Liljegren, James C.; Tschopp, Stephen; Rogers, Kevin; Wasmer, Fred; Liljegren, Lucia] Argonne Natl Lab, Argonne, IL 60439 USA. [Myirski, Michael] USA, Chem Mat Agcy, Edgewood, MD USA. RP Liljegren, JC (reprint author), Argonne Natl Lab, 9700 S Cass Ave, Argonne, IL 60439 USA. EM jcliljegren@anl.gov FU U. S. Army Chemical Materials Agency, Chemical Stockpile Emergency Preparedness Program [7D22 CM7007]; U. S. Department of Energy Office of Science laboratory [DE-AC02-06CH11357] FX This work was supported by the U. S. Army Chemical Materials Agency, Chemical Stockpile Emergency Preparedness Program, under Contract MIPR 7D22 CM7007 Amend 01 Rev 12. The submitted manuscript has been created by UChicago Argonne, LLC, Operator of Argonne National Laboratory ("Argonne''). Argonne, a U. S. Department of Energy Office of Science laboratory, is operated under Contract DE-AC02-06CH11357. The U. S. government retains for itself, and others acting on its behalf, a paid-up nonexclusive, irrevocable worldwide license in said article to reproduce, prepare derivative works, distribute copies to the public, and perform publicly and display publicly, by or on behalf of the government. NR 18 TC 2 Z9 3 U1 0 U2 2 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0739-0572 J9 J ATMOS OCEAN TECH JI J. Atmos. Ocean. Technol. PD AUG PY 2009 VL 26 IS 8 BP 1510 EP 1526 DI 10.1175/2009JTECHA1268.1 PG 17 WC Engineering, Ocean; Meteorology & Atmospheric Sciences SC Engineering; Meteorology & Atmospheric Sciences GA 481IN UT WOS:000268801300005 ER PT J AU Hanson, JL Tracy, BA Tolman, HL Scott, RD AF Hanson, Jeffrey L. Tracy, Barbara A. Tolman, Hendrik L. Scott, R. Douglas TI Pacific Hindcast Performance of Three Numerical Wave Models SO JOURNAL OF ATMOSPHERIC AND OCEANIC TECHNOLOGY LA English DT Article ID ROLL BUOYS; WIND; SPECTRA; PITCH AB Although mean or integral properties of wave spectra are typically used to evaluate numerical wave model performance, one must look into the spectral details to identify sources of model deficiencies. This creates a significant problem, as basin-scale wave models can generate millions of independent spectral values. To facilitate selection of a wave modeling technology for producing a multidecade Pacific hindcast, a new approach was developed to reduce the spectral content contained in detailed wave hindcasts to a convenient set of performance indicators. The method employs efficient image processing tools to extract windsea and swell wave components from monthly series of nondirectional and directional wave spectra. Using buoy observations as ground truth, both temporal correlation (TC) and quantile-quantile (QQ) statistical analyses are used to quantify hindcast skill in reproducing measured wave component height, period, and direction attributes. An integrated performance analysis synthesizes the TC and QQ results into a robust assessment of prediction skill and yields distinctive diagnostics on model inputs and source term behavior. The method is applied to a set of Pacific basin hindcasts computed using the WAM, WAVEWATCH III, and WAVAD numerical wave models. The results provide a unique assessment of model performance and have guided the selection of WAVEWATCH III for use in Pacific hindcast production runs for the U. S. Army Corps of Engineers Wave Information Studies Program. C1 [Hanson, Jeffrey L.] USA, Corps Engineers, Field Res Facil, Duck, NC USA. [Tracy, Barbara A.] USA, Corps Engineers, Waterways Expt Stn, Vicksburg, MS 39180 USA. [Tolman, Hendrik L.] NOAA NCEP Environm Modeling Ctr, Camp Springs, MD USA. [Scott, R. Douglas] WF Baird & Associates Coastal Engineers Ltd, Ottawa, ON, Canada. RP Hanson, JL (reprint author), USACE Field Res Facil, 1261 Duck Rd, Kitty Hawk, NC 27949 USA. EM jeffrey.l.hanson@usace.army.mil NR 41 TC 36 Z9 40 U1 0 U2 10 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0739-0572 J9 J ATMOS OCEAN TECH JI J. Atmos. Ocean. Technol. PD AUG PY 2009 VL 26 IS 8 BP 1614 EP 1633 DI 10.1175/2009JTECHO650.1 PG 20 WC Engineering, Ocean; Meteorology & Atmospheric Sciences SC Engineering; Meteorology & Atmospheric Sciences GA 481IN UT WOS:000268801300013 ER PT J AU Branstetter, JG Jackson, SR Haggard, WO Richelsoph, KC Wenke, JC AF Branstetter, J. G. Jackson, S. R. Haggard, W. O. Richelsoph, K. C. Wenke, J. C. TI Locally-administered antibiotics in wounds in a limb SO JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME LA English DT Article ID BONE-GRAFT SUBSTITUTE; OPEN FRACTURES; CALCIUM-SULFATE; DELIVERY-SYSTEM; INFECTION; BEADS; IRRIGATION; TOBRAMYCIN; VANCOMYCIN; DEFECTS AB We used a goat model of a contaminated musculoskeletal defect to determine the effectiveness of rapidly-resorbing calcium-sulphate pellets containing amikacin to reduce the local bacterial count. Our findings showed that this treatment eradicated the bacteria quickly, performed as well as standard polymethylmethacrylate mixed with an antibiotic and had many advantages over the latter. The pellets were prepared before surgery and absorbed completely. They released all of the antibiotic and did not require a subsequent operation for their removal. Our study indicated that locally administered antibiotics reduced bacteria within the wound rapidly. This method of treatment may have an important role in decreasing the rate of infection in contaminated wounds. C1 [Branstetter, J. G.; Jackson, S. R.; Haggard, W. O.; Richelsoph, K. C.; Wenke, J. C.] USA, Inst Surg Res, Houston, TX USA. RP Wenke, JC (reprint author), Extrem Trauma & Regenerat Med Task Area, 3400 Rawley E Chambers Ave, San Antonio, TX 78234 USA. EM Joseph.Wenke@us.army.mil FU Orthopaedic Extremity Trauma Research Program [W81XWH-07-0206] FX The authors received funding from the Orthopaedic Extremity Trauma Research Program (OTRP W81XWH-07-0206) to support this project. Neither they nor a member of their immediate families received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, division, center, clinical practice, or other charitable or nonprofit organisation with which the authors, or a member of their immediate families, are affiliated or associated. NR 31 TC 16 Z9 16 U1 0 U2 3 PU BRITISH EDITORIAL SOC BONE JOINT SURGERY PI LONDON PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND SN 0301-620X J9 J BONE JOINT SURG BR JI J. Bone Joint Surg.-Br. Vol. PD AUG PY 2009 VL 91B IS 8 BP 1106 EP 1109 DI 10.1302/0301-620X.91B8.22216 PG 4 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 487FZ UT WOS:000269257700025 PM 19651846 ER PT J AU Shi, XR Garcia, GE Neill, RJ Gordon, RK AF Shi, Xuerong Garcia, Gregory E. Neill, Roger J. Gordon, Richard K. TI TCEP Treatment Reduces Proteolytic Activity of BoNT/B in Human Neuronal SHSY-5Y Cells SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Article DE TCEP; BoNT; BOTULINUM NEUROTOXIN; SYNAPTOBREVIN-2; VAMP-2 ID BOTULINUM NEUROTOXIN SEROTYPE; INTERCHAIN DISULFIDE BOND; GEL-ELECTROPHORESIS; LIGHT-CHAINS; TOXIN; TETANUS; DITHIOTHREITOL; MECHANISM; PROTEINS; HEAVY AB The light chain (LC) of botulinum neurotoxin B (BoNT/B) is unable to enter target neuronal cells by itself. It is brought into the cell in association with the BoNT/B heavy chain (HC) through endocytosis. The BoNT HC-LC subunits are held together by a single disulfide bond. Intracellular reduction of this bond and separation of the two subunits activates the endopeptidase activity of the LC. This requirement suggests a strategy to prevent uptake by prophylactic reduction to disrupt the disulfide bond prior to endocytosis of the complex. We examined the utility of tris-(2-carboxyethyl)-phosphine hydrochloride (TCEP), a relatively non-toxic, non-sulfur containing disulfide bond reducing agent that lacks the undesirable properties of mercapto-containing reducing agents. We found that TCEP was as effective as DTT with maximal LC endopeptidase activation occurring at 1 mM, a concentration not toxic to the human neuronal cell line, SHSY-5Y. In these cells, 1 mM TCEP maximally protected against BoNT/B inhibition of [(3)H]-NA release, achieving 72% of the release from un-intoxicated controls. This effect appears to be due to the sparing of SNARE proteins as the levels of VAMP-2, the specific target of BoNT/B, were protected. These results show that TCEP disrupts the structure of BoNT/B by reduction of the LC and HC bridging disulfide bond and prevents neuronal intoxication. Since disulfide bond coupling between toxin subunits is a general motif for many toxins, e.g., ricin, snake venom, and all BoNT serotypes, this suggests that TCEP is a promising means to protect against these toxins by preventing cell penetration. J. Cell. Biochem. 107: 1021-1030, 2009. Published 2009 Wiley-Liss, Inc. C1 [Shi, Xuerong; Gordon, Richard K.] Walter Reed Army Inst Res, Div Regulated Activ, Dept Regulated Labs, Silver Spring, MD 20910 USA. [Garcia, Gregory E.] Walter Reed Army Inst Res, Dept Biochem Pharmacol, Div Biochem, Silver Spring, MD 20910 USA. [Neill, Roger J.] Walter Reed Army Inst Res, Dept Mol Pathol, Div Pathol, Silver Spring, MD 20910 USA. RP Shi, XR (reprint author), Walter Reed Army Inst Res, Div Regulated Activ, Dept Regulated Labs, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM xuerong.shi@amedd.army.mil FU Defense Threat Reduction Agency (DTRA) [3.10017_06_WR_B] FX Grant sponsor: The Defense Threat Reduction Agency (DTRA) proposal; Grant number: #3.10017_06_WR_B. NR 50 TC 11 Z9 11 U1 3 U2 18 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD AUG 1 PY 2009 VL 107 IS 5 BP 1021 EP 1030 DI 10.1002/jcb.22205 PG 10 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA 477TT UT WOS:000268542500021 PM 19492407 ER PT J AU Robinson, E D'Souza, AI Stapelbroek, MG Skokan, MR Kinch, MA Shih, HD Wijewarnasuriya, PS AF Robinson, E. D'Souza, A. I. Stapelbroek, M. G. Skokan, M. R. Kinch, M. A. Shih, H. D. Wijewarnasuriya, Priyalal S. TI Spectral Response Model for Front-Side-Illuminated Detectors SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 27th US Workshop on the Physics and Chemistry of II-VI Materials CY NOV 11-13, 2009 CL Las Vegas, NV SP USA CECOM Night Vis & Elect Sensors Directorate, USA Res Lab, USA SMDC, USN, Electro Opt Ctr, Penn State Appl Res Lab, Off Naval Res, USAF Res Lab, Minerals, Met & Mat Soc, Amer Phys Soc DE HgCdTe; spectral response; HD-VIP AB Spectral response of detectors can be modeled using a stack matrix approach. The different material layers that make up the detector form the optical stack. Light intensity is proportional to the square of the amplitude of the electromagnetic field's electric field component. Using the electric component of light, the model takes into account the reflective and transmission coefficients at the interface between two adjacent layers and the phase difference during propagation within each layer. The transition from one optical layer to another and the propagation within an optical layer can be formulated as 2 x 2 matrices; their multiplication through every optical layer makes up the stack matrix that defines the optical properties of the detector. Knowing the complex index of refraction for each layer in the detector, the intensity of light can be calculated at any point in the detector structure, which can then be used to determine the response of the detector as a function of wavelength. This model shows fairly good agreement with the experimental data, even revealing fine structure and etalon effects. Using this model, the detector can be designed to meet specific spectral characteristics. The spectral response model was used on high-density vertically interconnected photodiode front-side-illuminated photodiodes. C1 [Robinson, E.; D'Souza, A. I.; Stapelbroek, M. G.] DRS Sensors & Targeting Syst, Cypress, CA 90630 USA. [Skokan, M. R.; Kinch, M. A.; Shih, H. D.] DRS Sensors & Targeting Syst, Infrared Technol Div, Dallas, TX 75243 USA. [Wijewarnasuriya, Priyalal S.] USA, Res Lab, Adelphi, MD 20783 USA. RP Robinson, E (reprint author), DRS Sensors & Targeting Syst, 10600 Valley View Ave, Cypress, CA 90630 USA. EM erobin8@uic.edu NR 6 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 2009 VL 38 IS 8 BP 1624 EP 1627 DI 10.1007/s11664-009-0782-7 PG 4 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 480OK UT WOS:000268745400018 ER PT J AU Fulk, C Parodos, T Lamarre, P Tobin, S LoVecchio, P Markunas, J AF Fulk, C. Parodos, T. Lamarre, P. Tobin, S. LoVecchio, P. Markunas, J. TI Critical Thickness of Exponentially and Linearly Graded HgCdTe/CdZnTe SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 27th US Workshop on the Physics and Chemistry of II-VI Materials CY NOV 11-13, 2009 CL Las Vegas, NV SP USA CECOM Night Vis & Elect Sensors Directorate, USA Res Lab, USA SMDC, USN, Electro Opt Ctr, Penn State Appl Res Lab, Off Naval Res, USAF Res Lab, Minerals, Met & Mat Soc, Amer Phys Soc DE HgCdTe; CdZnTe; critical thickness; LPE; lattice matched ID CDHGTE EPITAXIAL LAYERS AB We have investigated the glide of strain-relaxing dislocations in closely lattice matched, liquid phase epitaxially (LPE) grown, HgCdTe. A generalized LPE heterostructure was modeled based on secondary-ion mass spectroscopy (SIMS) profile measurements. Critical thickness was predicted using a force balanced method which expands upon the work recently developed by Ayers. The behavior of dislocation dynamics is predicted with respect to exponentially and linearly graded metallurgical interfaces intrinsic to the high- temperature LPE growth process. The extended Ayers model is compared against x-ray topography and cross-sectional observations of misfit dislocations by the decoration of etch pits on cleaved HgCdTe/CdZnTe. The model predicts that, for bulk Cd/Zn compositions which are nearly lattice matched, the Zn compositional profile plays an important role in determining both the onset and distribution of misfit dislocations. C1 [Fulk, C.; Parodos, T.; Lamarre, P.; Tobin, S.; LoVecchio, P.] BAE Syst, Lexington, MA 02421 USA. [Markunas, J.] USA, RDECOM, CERDEC, NVESD, Ft Belvoir, VA 22060 USA. RP Fulk, C (reprint author), BAE Syst, 2 Forbes Rd, Lexington, MA 02421 USA. EM chad.fulk@baesystems.com NR 9 TC 0 Z9 0 U1 2 U2 10 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 2009 VL 38 IS 8 BP 1690 EP 1697 DI 10.1007/s11664-009-0801-8 PG 8 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 480OK UT WOS:000268745400027 ER PT J AU D'Orsogna, D Lamarre, P Bellotti, E Barbone, PE Smith, F Fulk, C Lovecchio, P Reine, MB Tobin, SP Markunas, J AF D'Orsogna, D. Lamarre, P. Bellotti, E. Barbone, P. E. Smith, F. Fulk, C. Lovecchio, P. Reine, M. B. Tobin, S. P. Markunas, J. TI A Novel Stress Characterization Technique for the Development of Low-Stress Ohmic Contacts to HgCdTe SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 27th US Workshop on the Physics and Chemistry of II-VI Materials CY NOV 11-13, 2009 CL Las Vegas, NV SP USA CECOM Night Vis & Elect Sensors Directorate, USA Res Lab, USA SMDC, USN, Electro Opt Ctr, Penn State Appl Res Lab, Off Naval Res, USAF Res Lab, Minerals, Met & Mat Soc, Amer Phys Soc DE HgCdTe detectors; ohmic contacts; HgCdTe stress ID FILMS; POLYCRYSTALLINE; (HGCD)TE AB HgCdTe material intended for long-wavelength infrared detection is particularly susceptible to damage from stress. As a result, an ideal ohmic contact needs to have good adhesion and low specific contact resistance. The contact should act as a diffusion barrier and induce the least amount of stress in the underlying material. In this paper we present a set of stress measurements from different ohmic contact materials deposited on short- and long-wavelength HgCdTe films grown by liquid-phase epitaxy (LPE). Using a new experimental technique we remove the substrate and measure the stress induced on single- and multilayered HgCdTe cantilevers. To interpret our results, we develop a theoretical model that describes the physics of elastic deformation in HgCdTe layers. Our model is based on classical thin-plate bending theory and explicitly takes into account the realistic boundary conditions that are present in the experimental setup by using a variational approach. C1 [D'Orsogna, D.; Bellotti, E.] Boston Univ, Dept Elect & Comp Engn, Boston, MA 02215 USA. [Lamarre, P.; Smith, F.] Photronix Inc, Burlington, MA 01803 USA. [Lamarre, P.; Fulk, C.; Lovecchio, P.; Reine, M. B.; Tobin, S. P.] BAE Syst, Lexington, MA 02421 USA. [Barbone, P. E.] Boston Univ, Dept Mech Engn, Boston, MA 02215 USA. [Markunas, J.] USA, RDECOM, CERDEC, NVESD, Ft Belvoir, VA 22060 USA. RP D'Orsogna, D (reprint author), Boston Univ, Dept Elect & Comp Engn, 8 St Marys St, Boston, MA 02215 USA. EM bellotti@bu.edu NR 20 TC 0 Z9 0 U1 1 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 2009 VL 38 IS 8 BP 1698 EP 1706 DI 10.1007/s11664-009-0790-7 PG 9 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 480OK UT WOS:000268745400028 ER PT J AU Stoltz, AJ Benson, JD Smith, PJ AF Stoltz, A. J. Benson, J. D. Smith, P. J. TI Plasma Passivation Etching for HgCdTe SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 27th US Workshop on the Physics and Chemistry of II-VI Materials CY NOV 11-13, 2009 CL Las Vegas, NV SP USA CECOM Night Vis & Elect Sensors Directorate, USA Res Lab, USA SMDC, USN, Electro Opt Ctr, Penn State Appl Res Lab, Off Naval Res, USAF Res Lab, Minerals, Met & Mat Soc, Amer Phys Soc DE HgCdTe; CdTe; ICP; argon; hydrogen; xenon; processing; plasma; dry ID CYCLOTRON-RESONANCE PLASMAS; WAVELENGTH; HG1-XCDXTE; CH4/H-2/AR; DETECTORS; SURFACE; ARRAYS; CDZNTE; CDTE AB Inductively coupled plasmas (ICP) are the high-density plasmas of choice for the processing of HgCdTe and related compounds. Most dry plasma process works have been performed on HgCdTe for pixel delineation and the p-to-n-type conversion of HgCdTe. We would like to use the advantages of "dry" plasma processing to perform passivation etching of HgCdTe. Plasma processing promises the ability to create small vias, 2 mu m or less with excellent uniformity across a wafer, good run-to-run uniformity, and good etch rate control. In this study we developed processes to controllably etch CdTe, the most common passivation material used for photovoltaic-based HgCdTe devices. We created a process based on xenon gas that allows for the slow controllable CdTe etch at only 0.035 mu m/min, with smooth morphology and rounded corners to promote further processing. C1 [Stoltz, A. J.; Benson, J. D.; Smith, P. J.] USA, RDECOM, CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA. RP Stoltz, AJ (reprint author), USA, RDECOM, CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA. NR 16 TC 2 Z9 2 U1 3 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 2009 VL 38 IS 8 BP 1741 EP 1745 DI 10.1007/s11664-009-0833-0 PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 480OK UT WOS:000268745400033 ER PT J AU Lamarre, P Fulk, C D'Orsogna, D Bellotti, E Smith, F LoVecchio, P Reine, MB Parodos, T Marciniec, J Tobin, SP Markunas, J AF Lamarre, P. Fulk, C. D'Orsogna, D. Bellotti, E. Smith, F. LoVecchio, P. Reine, M. B. Parodos, T. Marciniec, J. Tobin, S. P. Markunas, J. TI Characterization of Dislocations in HgCdTe Heteroepitaxial Layers Using a New Substrate Removal Technique SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 27th US Workshop on the Physics and Chemistry of II-VI Materials CY NOV 11-13, 2009 CL Las Vegas, NV SP USA CECOM Night Vis & Elect Sensors Directorate, USA Res Lab, USA SMDC, USN, Electro Opt Ctr, Penn State Appl Res Lab, Off Naval Res, USAF Res Lab, Minerals, Met & Mat Soc, Amer Phys Soc DE HgCdTe; defects; dislocations; transmission electron microscopy ID CHEMICAL VAPOR-DEPOSITION; DEFECTS AB Dislocations are known to influence the electrical and optical properties of long-wavelength infrared (LWIR) HgCdTe detectors and have been shown to limit the performance of arrays fabricated on heteroepitaxial substrates. To help better understand dislocations in HgCdTe, a new method for preparing HgCdTe diagnostic epitaxial single-crystal samples by chemically removing the supporting CdZnTe substrate has been developed. Using this new sample preparation technique, the behavior of misfit and threading dislocations in HgCdTe epitaxial layers has been investigated by using a defect etch to reveal the dislocations present in the thin HgCdTe films. In most cases etch pits on the surface of the film are spatially correlated with etch pits on the bottom of the HgCdTe film. The small displacements of the related etch pits were used to obtain crystallographic information concerning the paths followed by threading dislocations on allowed slip planes in the HgCdTe crystal. In addition, transmission electron microscopy (TEM) is used to obtain more specific information regarding the Burgers vector of the dislocation. While this new sample preparation technique is useful for studying dislocations in HgCdTe epitaxial layers, it can also be used to study stress from ohmic contacts and passivation layers. The technique can be used for both liquid-phase epitaxy (LPE)- and molecular-beam epitaxy (MBE)-grown HgCdTe on CdZnTe substrates. C1 [Lamarre, P.; Smith, F.] Photronix Inc, Burlington, MA 01803 USA. [Lamarre, P.; Fulk, C.; LoVecchio, P.; Reine, M. B.; Parodos, T.; Marciniec, J.; Tobin, S. P.] BAE Syst, Lexington, MA 02421 USA. [D'Orsogna, D.; Bellotti, E.] Boston Univ, Boston, MA 02215 USA. [Markunas, J.] USA, RDECOM, CERDEC, NVESD, Ft Belvoir, VA 22060 USA. RP Lamarre, P (reprint author), Photronix Inc, 35 Sandybrook Rd, Burlington, MA 01803 USA. EM Lamarre@earthlink.net NR 16 TC 3 Z9 3 U1 1 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 2009 VL 38 IS 8 BP 1746 EP 1754 DI 10.1007/s11664-009-0771-x PG 9 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 480OK UT WOS:000268745400034 ER PT J AU Benson, JD Smith, PJ Jacobs, RN Markunas, JK Jaime-Vasquez, M Almeida, LA Stoltz, A Bubulac, LO Groenert, M Wijewarnasuriya, PS Brill, G Chen, Y Lee, U AF Benson, J. D. Smith, P. J. Jacobs, R. N. Markunas, J. K. Jaime-Vasquez, M. Almeida, L. A. Stoltz, A. Bubulac, L. O. Groenert, M. Wijewarnasuriya, P. S. Brill, G. Chen, Y. Lee, U. TI Topography and Dislocations in (112)B HgCdTe/CdTe/Si SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 27th US Workshop on the Physics and Chemistry of II-VI Materials CY NOV 11-13, 2009 CL Las Vegas, NV SP USA CECOM Night Vis & Elect Sensors Directorate, USA Res Lab, USA SMDC, USN, Electro Opt Ctr, Penn State Appl Res Lab, Off Naval Res, USAF Res Lab, Minerals, Met & Mat Soc, Amer Phys Soc DE HgCdTe; CdTe/Si; molecular beam epitaxy; atomic force microscopy; etch pit density ID MOLECULAR-BEAM EPITAXY; CADMIUM TELLURIDE; DIODE PERFORMANCE; HGCDTE; SI; GROWTH; HETEROEPITAXY; SURFACE; CDTE AB Scanning electron microscopy (SEM), atomic force microscopy (AFM), and x-ray diffraction (XRD) measurements all indicate an approximate factor of ten increase in the Everson etch pit density (EPD) over standard Nomarski microscopy Everson EPD determination. A new (112)B CdTe/Si EPD etch has also been demonstrated which reduces the surface roughness of the etched epilayer and makes etch pit density determination less problematic. C1 [Benson, J. D.; Smith, P. J.; Jacobs, R. N.; Markunas, J. K.; Jaime-Vasquez, M.; Almeida, L. A.; Stoltz, A.; Bubulac, L. O.; Groenert, M.] USA, RDECOM, CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA. [Wijewarnasuriya, P. S.; Brill, G.; Chen, Y.; Lee, U.] USA, Res Lab, Adelphi, MD USA. RP Benson, JD (reprint author), USA, RDECOM, CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA. EM dbenson@nvl.army.mil RI Brill, Gregory/G-4877-2013 NR 20 TC 13 Z9 15 U1 0 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 2009 VL 38 IS 8 BP 1771 EP 1775 DI 10.1007/s11664-009-0758-7 PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 480OK UT WOS:000268745400037 ER PT J AU Indest, KJ Buchholz, WG Faeder, JR Setlow, P AF Indest, Karl J. Buchholz, Wallace G. Faeder, Jim R. Setlow, Peter TI Workshop Report: Modeling the Molecular Mechanism of Bacterial Spore Germination and Elucidating Reasons for Germination Heterogeneity SO JOURNAL OF FOOD SCIENCE LA English DT Editorial Material DE bacterial spores; microbial survival; modeling ID BACILLUS-SUBTILIS SPORES; CLOSTRIDIUM-PERFRINGENS; DIPICOLINIC ACID; INNER MEMBRANE; SPOVA OPERON; PROTEIN; CEREUS; PEPTIDOGLYCAN; LOCALIZATION; DORMANCY AB Over the course of 2 days, top researchers in the fields of bacterial spore biology and computational biology discussed approaches to determine the cause of spore germination heterogeneity. Biological and mathematical data gaps were identified, and experimental approaches and computational strategies for modeling spore germination were presented and evaluated. As a result of these interactions, future research directions were defined, the outcome of which should result in a robust model to help define the molecular mechanism(s) of spore germination. Mechanistic understanding of germination will be instrumental for developing novel sterilization, treatment, and decontamination strategies to mitigate threats posed by spores. C1 [Buchholz, Wallace G.] USA, Res Off, Div Life Sci, Durham, NC 27703 USA. [Indest, Karl J.] USA, Engineer Res & Dev Ctr, Environm Proc Branch, Vicksburg, MS 39180 USA. [Faeder, Jim R.] Univ Pittsburgh, Sch Med, Dept Computat Biol, Pittsburgh, PA 15260 USA. [Setlow, Peter] Univ Connecticut, Ctr Hlth, Dept Mol Microbiol & Struct Biol, Farmington, CT 06030 USA. RP Buchholz, WG (reprint author), USA, Res Off, Div Life Sci, 4300 S Miami Blvd, Durham, NC 27703 USA. EM wallace.buchholz@us.army.mil NR 42 TC 13 Z9 13 U1 1 U2 2 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0022-1147 J9 J FOOD SCI JI J. Food Sci. PD AUG PY 2009 VL 74 IS 6 BP R73 EP R78 DI 10.1111/j.1750-3841.2009.01245.x PG 6 WC Food Science & Technology SC Food Science & Technology GA 479BS UT WOS:000268634400050 PM 19723224 ER PT J AU Kamau, E Takhampunya, R Li, T Kelly, E Peachman, KK Lynch, JA Sun, PF Palmer, DR AF Kamau, Edwin Takhampunya, Ratree Li, Tao Kelly, Eileen Peachman, Kristina K. Lynch, Julia A. Sun, Peifang Palmer, Dupeh R. TI Dengue virus infection promotes translocation of high mobility group box 1 protein from the nucleus to the cytosol in dendritic cells, upregulates cytokine production and modulates virus replication SO JOURNAL OF GENERAL VIROLOGY LA English DT Article ID TUMOR-NECROSIS-FACTOR; HEMORRHAGIC-FEVER; DISEASE SEVERITY; HMGB1 RELEASE; DNA-BINDING; INTERFERON; ACTIVATION; SEPSIS; ALPHA; HMG-1 AB High mobility group box 1 (HMGB1) protein functions in regulation of transcription, cellular activation and pro-inflammatory responses. However, the potential role of HMGB1 during viral infection has not been investigated. This study attempted to elucidate whether the HMGB1-mediated inflammatory response contributes to the pathogenesis of dengue virus (DENV) infection. Our data showed that HMGB1 was released at low DENV infection levels (m.o.i. of 1) under non-necrotic conditions by human dendritic cells (DCs). When DENV-infected DCs were co-cultured with autologous T cells, there was increased production of HMGB1 by both cell types. HMGB1 regulated tumour necrosis factor alpha, interleukin (IL)-6, IL-8 and alpha interferon secretion in DENV-infected DCs. Additionally, increased HMGB1 production was associated with reduced DENV replication titres in DCs. These results suggest that HMGB1 production influences DENV infection in susceptible hosts. C1 [Kamau, Edwin; Li, Tao; Kelly, Eileen; Lynch, Julia A.; Palmer, Dupeh R.] Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD 20910 USA. [Takhampunya, Ratree] Georgetown Univ, Sch Med, Dept Microbiol & Immunol, Washington, DC 20057 USA. [Peachman, Kristina K.] Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD 21910 USA. [Sun, Peifang] Naval Med Res Ctr, Viral & Rickettsial Dis Dept, Silver Spring, MD 20910 USA. RP Kamau, E (reprint author), Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD 20910 USA. EM edwin.kamau@amedd.army.mil NR 53 TC 26 Z9 30 U1 0 U2 1 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 0022-1317 J9 J GEN VIROL JI J. Gen. Virol. PD AUG PY 2009 VL 90 BP 1827 EP 1835 DI 10.1099/vir.0.009027-0 PG 9 WC Biotechnology & Applied Microbiology; Virology SC Biotechnology & Applied Microbiology; Virology GA 479YX UT WOS:000268699400006 PM 19369409 ER PT J AU Furey, J Morgan, C Fields, M AF Furey, John Morgan, Cliff Fields, Morris TI Passive detection of gamma ray shadows from small-scale soil surface anomalies SO JOURNAL OF GEOPHYSICAL RESEARCH-SOLID EARTH LA English DT Article ID SCATTERING; RADIATION; LANDMINES AB We exhibit theoretical and experimental evidence that some surface anomalies can be passively detected from their shadowing of low-level gamma rays emitted from natural soil. Surface objects on the order of decimeter size with high electron density cause variable attenuation in several bands of gamma ray energies, while some surface holes cause other detectable changes in the gamma background. Using a broadly collimated portable 7.6 x 7.6 cm cylindrical NaI (Tl) scintillation detector, we characterize the small-scale (on the order of meter scale or less) homogeneity of gamma rays at the soil surface in the context of detectability of objects and holes. We suggest that passive detection of anomalies below the surface may have impractically low count rates due to the greater collimation needed. C1 [Furey, John; Morgan, Cliff; Fields, Morris] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Furey, J (reprint author), USA, Environm Lab, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM john.s.furey@usace.army.mil FU U.S. Army Engineer Military Engineering Research Program; U.S. Army Engineer Research and Development Center, Vicksburg, MS FX This research was supported by the U.S. Army Engineer Military Engineering Research Program at the U.S. Army Engineer Research and Development Center, Vicksburg, MS. NR 33 TC 1 Z9 1 U1 0 U2 1 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9313 EI 2169-9356 J9 J GEOPHYS RES-SOL EA JI J. Geophys. Res.-Solid Earth PD AUG 1 PY 2009 VL 114 AR B08202 DI 10.1029/2008JB006226 PG 7 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 479BG UT WOS:000268633200002 ER PT J AU King, CS Khandhar, S Burton, N Shlobin, OA Ahmad, S Lefrak, E Barnett, SD Nathan, SD AF King, Christopher S. Khandhar, Sandeep Burton, Nelson Shlobin, Oksana A. Ahmad, Shahzad Lefrak, Edward Barnett, Scott D. Nathan, Steven D. TI Native Lung Complications in Single-lung Transplant Recipients and the Role of Pneumonectomy SO JOURNAL OF HEART AND LUNG TRANSPLANTATION LA English DT Article ID OPERATIVE MORTALITY; CONTRALATERAL PNEUMONECTOMY; COMPLETION PNEUMONECTOMY; MORBIDITY; CANCER; FIBROSIS; DISEASE AB Single-lung transplant recipients may develop complications in their native kings that may have an impact on outcomes. One potential therapeutic option is native lung pneumonectomy. The purpose of this study was to assess the impact of native lung complications on post-transplant survival in single-lung transplant recipients. We also aimed to determine the morbidity and mortality associated with native lung pneumonectomy (NLP). A retrospective review of all single-lung transplant recipients at Our institution front January 1, 1998 to July 15, 2008 was performed. Patients were stratified to one of three groups: no native lung complications; native lung complications requiring native lung pneumonectomy; and native lung complications not managed with native lung pneumonectomy. Survival post-transplant and post-native lung complication were the primary end-points of the study. Significant native lung complications developed in 25 of 180 single-lung transplants (13.8%). Median post-transplant survival was lower in single-lung transplant recipients with significant native lung Complications (3.2 years vs 5.3 years, p = 0.002). NLP was performed in 11 patients. Post-operative complications developed in 4 of I I cases (36.4%), but all patients survived to hospital discharge. There was no significant difference in median survival between single-lung transplant recipients undergoing native lung pneumonectomy and single-lung transplant recipients without native lung complications (4.3 years vs 5.1 years, p = 0.478). Native lung complications impact post-transplant survival in single-lung transplant recipients and may partly explain why outcomes with single-lung transplantation are inferior to those of bilateral lung transplantation. NLP can be performed with acceptable morbidity and mortality. J Heart Lung Transplant 2009;28:851-6. Copyright (C) 2009 by the international Society for Heart and Lung Transplantation. C1 [King, Christopher S.] Walter Reed Army Med Ctr, Dept Pulm Crit Care Med, Washington, DC 20016 USA. [Khandhar, Sandeep; Burton, Nelson; Lefrak, Edward; Barnett, Scott D.] Inova Fairfax Hosp, Dept Cardiothorac Surg, Falls Church, VA USA. [Shlobin, Oksana A.; Ahmad, Shahzad; Nathan, Steven D.] Inova Fairfax Hosp, Lung Transplantat Program, Falls Church, VA USA. RP King, CS (reprint author), Walter Reed Army Med Ctr, Dept Pulm Crit Care Med, 3831 Rodman St NW,F30, Washington, DC 20016 USA. EM csking123@hotmail.com NR 15 TC 21 Z9 23 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1053-2498 J9 J HEART LUNG TRANSPL JI J. Heart Lung Transplant. PD AUG PY 2009 VL 28 IS 8 BP 851 EP 856 DI 10.1016/j.healun.2009.04.023 PG 6 WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery; Transplantation SC Cardiovascular System & Cardiology; Respiratory System; Surgery; Transplantation GA 480MM UT WOS:000268739000017 PM 19632585 ER PT J AU Kester, KE Cummings, JF Ofori-Anyinam, O Ockenhouse, CF Krzych, U Moris, P Schwenk, R Nielsen, RA Debebe, Z Pinelis, E Juompan, L Williams, J Dowler, M Stewart, VA Wirtz, RA Dubois, MC Lievens, M Cohen, J Ballou, WR Heppner, DG AF Kester, Kent E. Cummings, James F. Ofori-Anyinam, Opokua Ockenhouse, Christian F. Krzych, Urszula Moris, Philippe Schwenk, Robert Nielsen, Robin A. Debebe, Zufan Pinelis, Evgeny Juompan, Laure Williams, Jack Dowler, Megan Stewart, V. Ann Wirtz, Robert A. Dubois, Marie-Claude Lievens, Marc Cohen, Joe Ballou, W. Ripley Heppner, D. Gray, Jr. CA RTS S Vaccine Evaluation Grp TI Randomized, Double-Blind, Phase 2a Trial of Falciparum Malaria Vaccines RTS,S/AS01B and RTS,S/AS02A in Malaria-Naive Adults: Safety, Efficacy, and Immunologic Associates of Protection SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT 54th Annual Meeting of the American-Society-for-Tropical-Medicine-and-Hygiene CY DEC 11-15, 2005 CL Washington, DC SP Amer Soc Trop Med & Hyg ID CIRCUMSPOROZOITE PROTEIN VACCINE; INSTITUTE-OF-RESEARCH; PLASMODIUM-FALCIPARUM; IMMUNOGENICITY; CHILDREN; ANTIGEN; RTS,S; FORMULATIONS; RECOGNITION; INFECTION AB Background. To further increase the efficacy of malaria vaccine RTS,S/AS02A, we tested the RTS, S antigen formulated using the AS01B Adjuvant System (GlaxoSmithKline Biologicals). Methods. In a double-blind, randomized trial, 102 healthy volunteers were evenly allocated to receive RTS,S/AS01B or RTS,S/AS02A vaccine at months 0, 1, and 2 of the study, followed by malaria challenge. Protected vaccine recipients were rechallenged 5 months later. Results. RTS,S/AS01B and RTS,S/AS02A were well tolerated and were safe. The efficacy of RTS,S/AS01B and RTS,S/AS02A was 50% (95% confidence interval [CI], 32.9%-67.1%) and 32% (95% CI, 17.6%-47.6%), respectively. At the time of initial challenge, the RTS, S/AS01B group had greater circumsporozoite protein (CSP)-specific immune responses, including higher immunoglobulin (Ig) G titers, higher numbers of CSP-specific CD4(+) T cells expressing >= 2 activation markers (interleukin-2, interferon [IFN]-gamma, tumor necrosis factor-alpha, or CD40L), and more ex vivo IFN-gamma enzyme-linked immunospots (ELISPOTs) than did the RTS,S/AS02A group. Protected vaccine recipients had a higher CSP-specific IgG titer (geometric mean titer, 188 vs 73 mg/mL; P <.001), higher numbers of CSP-specific CD4(+) T cells per 106 CD4(+) T cells (median, 963 vs 308 CSP-specific CD4(+) T cells/10(6) CD4(+) T cells; P <.001), and higher numbers of ex vivo IFN-gamma ELISPOTs (mean, 212 vs 96 spots/million cells; P <.001). At rechallenge, 4 of 9 vaccine recipients in each group were still completely protected. Conclusions. The RTS,S/AS01B malaria vaccine warrants comparative field trials with RTS,S/AS02A to determine the best formulation for the protection of children and infants. The association between complete protection and immune responses is a potential tool for further optimization of protection. C1 [Kester, Kent E.; Cummings, James F.; Ockenhouse, Christian F.; Krzych, Urszula; Schwenk, Robert; Nielsen, Robin A.; Debebe, Zufan; Pinelis, Evgeny; Juompan, Laure; Williams, Jack; Dowler, Megan; Stewart, V. Ann; Heppner, D. Gray, Jr.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Wirtz, Robert A.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Ofori-Anyinam, Opokua; Moris, Philippe; Dubois, Marie-Claude; Lievens, Marc; Cohen, Joe; Ballou, W. Ripley] GlaxoSmithKline Biol, Rixensart, Belgium. RP Kester, KE (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM kent.kester@us.army.mil RI Kester, Kent/A-2114-2011 OI Kester, Kent/0000-0002-5056-0802 NR 30 TC 216 Z9 220 U1 5 U2 23 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD AUG 1 PY 2009 VL 200 IS 3 BP 337 EP 346 DI 10.1086/600120 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 465RH UT WOS:000267604000004 PM 19569965 ER PT J AU Tiberkevich, V Krivorotov, I Gerhart, G Slavin, A AF Tiberkevich, Vasil Krivorotov, Ilya Gerhart, Grant Slavin, Andrei TI Compensation of nonlinear phase noise in an in-plane-magnetized anisotropic spin-torque oscillator SO JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS LA English DT Article DE Spin-torque oscillator; Generation linewidth; Thermal noise; Nonlinearity ID POLARIZED CURRENT; EXCITATION AB A theory of generation linewidth of a spin-torque oscillator (STO) based on an in-plane-magnetized nano-pillar with an anisotropic "free" magnetic layer has been developed. It is predicted that by choosing the direction of the in-plane bias magnetic field H(0) along the "hard" anisotropy axis of the STO "free" layer and the magnitude of this field to be four times larger than the anisotropy field H(A) (H0 = 4H(A)) it would be possible to compensate the nonlinear phase noise and to achieve the minimum value of the generation linewidth, characteristic for an auto-oscillator without an onlinear frequency shift. (C) 2009 Elsevier B.V. All rights reserved. C1 [Tiberkevich, Vasil; Slavin, Andrei] Oakland Univ, Dept Phys, Rochester, MI 48309 USA. [Krivorotov, Ilya] Univ Calif Irvine, Sch Phys Sci, Irvine, CA 92697 USA. [Gerhart, Grant] USA, TARDEC, Warren, MI 48397 USA. RP Tiberkevich, V (reprint author), Oakland Univ, Dept Phys, Rochester, MI 48309 USA. EM tyberkev@oakland.edu RI Tiberkevich, Vasil/A-8697-2008 OI Tiberkevich, Vasil/0000-0002-8374-2565 FU U.S. Department of Defense [W911NF-04-1-0247]; U.S.Army TARDEC, RDECOM [W56HZV-07-P-L612]; U.S. National Science Foundation [ECCS-0653901]; Oakland University Foundation FX This work was in part supported by MURI Grant no. W911NF-04-1-0247 from the U.S. Department of Defense, by Contract no. W56HZV-07-P-L612 from the U.S.Army TARDEC, RDECOM, by Grant no. ECCS-0653901 from the U.S. National Science Foundation, and by the Oakland University Foundation. NR 10 TC 12 Z9 12 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-8853 J9 J MAGN MAGN MATER JI J. Magn. Magn. Mater. PD AUG PY 2009 VL 321 IS 16 BP 153 EP 155 DI 10.1016/j.jmmm.2009.03.013 PG 3 WC Materials Science, Multidisciplinary; Physics, Condensed Matter SC Materials Science; Physics GA 445FQ UT WOS:000266036000001 ER PT J AU Al-Smadi, YM Russell, K Sodhi, RS AF Al-Smadi, Yahia M. Russell, Kevin Sodhi, Raj S. TI Planar Four-Bar Motion Generation With Static Structural Conditions SO JOURNAL OF MECHANISMS AND ROBOTICS-TRANSACTIONS OF THE ASME LA English DT Article AB A planar four-bar motion generation model that also includes static structural conditions is formulated and demonstrated in this work. Using this model, planar four-bar motion generators are also synthesized with respect to static torque, deflection constraints, and buckling constraints for a given rigid-body load. [DOI: 10.1115/1.3147191] C1 [Al-Smadi, Yahia M.] AECOM, Special Struct Grp, New York, NY 10005 USA. [Russell, Kevin] USA, Res Dev & Engn Ctr, Armament Engn & Technol Ctr, Picatinny Arsenal, NJ 07806 USA. [Sodhi, Raj S.] New Jersey Inst Technol, Dept Mech Engn, Newark, NJ 07102 USA. RP Al-Smadi, YM (reprint author), AECOM, Special Struct Grp, New York, NY 10005 USA. EM yahia.al-smadi@aecom.com; kevin.russell1@us.army.mil; rajpal.s.sodhi@njit.edu NR 19 TC 2 Z9 2 U1 0 U2 1 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 1942-4302 J9 J MECH ROBOT JI J. Mech. Robot. PD AUG PY 2009 VL 1 IS 3 AR 031009 DI 10.1115/1.3147191 PG 6 WC Engineering, Mechanical; Robotics SC Engineering; Robotics GA V17SS UT WOS:000207957500009 ER PT J AU Bommineni, YR Dick, EJ Estep, JS Van de Berg, JL Hubbard, GB AF Bommineni, Yugendar R. Dick, Edward J., Jr. Estep, J. Scot Van de Berg, John L. Hubbard, Gene B. TI Fatal acute Chagas disease in a chimpanzee SO JOURNAL OF MEDICAL PRIMATOLOGY LA English DT Article DE Ape; fatal case; non-human primate; protozoa; Trypanosoma cruzi ID TRYPANOSOMA-CRUZI INFECTION; ST-CATHERINES ISLAND; RHESUS-MONKEYS; HEART-DISEASE; WILD RACCOONS; PATHOLOGICAL FINDINGS; MACACA-MULATTA; REACTIVATION; GEORGIA; PHASE AB Background Chagas disease (CD) or American trypanosomiasis is caused by a hemoflagellate protozoan, Trypanosoma cruzi. This organism has been isolated from more than 100 mammalian species and several insect vectors demonstrating a wide host distribution and low host specificity. Methods A 23-year-old male chimpanzee died acutely and a complete necropsy was performed to evaluate gross and microscopic pathologic changes. After observation of trypanosomal amastigotes in the myocardium, PCR and immunohistochemistry was employed to confirm the diagnosis of T. cruzi. Results Gross findings were consistent with mild congestive heart failure. Microscopic findings included multifocal myocardial necrosis associated with severe lymphocytic to mixed inflammatory infiltrates, edema, and mild chronic interstitial fibrosis. Multifocal intracytoplasmic amastigotes morphologically consistent with T. cruzi were observed in cardiac myofibers. Trypanosoma cruzi was confirmed by PCR and immunohistochemistry. Conclusion We report, to the best of our knowledge, the first fatal spontaneous case of T. cruzi infection in a chimpanzee. C1 [Bommineni, Yugendar R.; Dick, Edward J., Jr.; Van de Berg, John L.; Hubbard, Gene B.] SW Fdn Biomed Res, SW Natl Primate Res Ctr, San Antonio, TX 78245 USA. [Estep, J. Scot] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Dick, EJ (reprint author), SW Fdn Biomed Res, SW Natl Primate Res Ctr, POB 760549, San Antonio, TX 78245 USA. EM edick@sfbr.org FU NIH/NCRR [P51 RR013986]; Southwest Foundation for Biomedical Research; Research Facilities Improvement Program [C06 RR016228] FX We wish to thank Marie Silva, Michaelle Hohmann, Denise Trejo, M.G. Bonecini-Almeida, and personnel of the Armed Forces Institute of Pathology for their individual contributions to the publication. This research was funded in part by NIH/NCRR grant P51 RR013986 to the Southwest National Primate Research Center, Southwest Foundation for Biomedical Research. Chimpanzees were housed in facilities constructed with support from Research Facilities Improvement Program Grant C06 RR016228 from the National Center for Research Resources, NIH. NR 34 TC 9 Z9 9 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0047-2565 J9 J MED PRIMATOL JI J. Med. Primatol. PD AUG PY 2009 VL 38 IS 4 BP 247 EP 251 DI 10.1111/j.1600-0684.2009.00348.x PG 5 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 466ZP UT WOS:000267705000005 PM 19281482 ER PT J AU Currano, LJ Churaman, WA AF Currano, Luke J. Churaman, Wayne A. TI Energetic Nanoporous Silicon Devices SO JOURNAL OF MICROELECTROMECHANICAL SYSTEMS LA English DT Article DE Explosive; nanoenergetic; nanoporous silicon ID THERMAL-CONDUCTIVITY; POROUS SILICON; EXPLOSIVE DEVICES; FILMS AB Nanoporous energetic silicon is a promising new material for on-chip integration of energetic materials. We demonstrate several advances in the integration of nanoporous energetic silicon, including monolithic integration of a hotwire initiator on nanoporous energetic silicon, with 2.8-V ignition. We also demonstrate lithographically patterned arrays of energetic devices that are independently addressable through integrated initiators with no sympathetic ignition. Monolithic integration of the energetic material with a surface micromachined microelectromechanical systems sensor is also shown. The performance and failure mechanisms of the hotwire initiator are examined, and preliminary measurements of the thrust and propagation velocity are reported. C1 [Currano, Luke J.; Churaman, Wayne A.] USA, Res Lab, Adelphi, MD 20783 USA. RP Currano, LJ (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM lcurrano@arl.army.mil; wayne.churaman@arl.army.mil FU U. S. Army Armament Research, Development, and Engineering Center FX This work was supported in part by the U. S. Army Armament Research, Development, and Engineering Center. Subject Editor G. Stemme. NR 19 TC 44 Z9 46 U1 1 U2 14 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1057-7157 J9 J MICROELECTROMECH S JI J. Microelectromech. Syst. PD AUG PY 2009 VL 18 IS 4 BP 799 EP 807 DI 10.1109/JMEMS.2009.2023883 PG 9 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA 479EE UT WOS:000268641700004 ER PT J AU Yao, CP Williams, AJ Ottens, AK Lu, XCM Liu, MC Hayes, RL Wang, KK Tortella, FC Dave, JR AF Yao, Changping Williams, Anthony J. Ottens, Andrew K. Lu, X. -C. May Liu, Ming Cheng Hayes, Ronald L. Wang, Kevin K. Tortella, Frank C. Dave, Jitendra R. TI P43/pro-EMAPII: A Potential Biomarker for Discriminating Traumatic Versus Ischemic Brain Injury SO JOURNAL OF NEUROTRAUMA LA English DT Article DE brain injury biomarkers; diagnostic biomarker; middle cerebral artery occlusion; penetrating ballistic-like brain injury; protein expression ID TRANSFER-RNA SYNTHETASE; CYTOKINE EMAP-II; POLYPEPTIDE-II; PROINFLAMMATORY CYTOKINE; LESIONAL EXPRESSION; MICROGLIAL CELLS; RAT; P43; PROTEIN; NEUROPROTECTION AB To gain additional insights into the pathogenic cellular and molecular mechanisms underlying different types of brain injury (e. g., trauma versus ischemia), recently attention has focused on the discovery and study of protein biomarkers. In previous studies, using a high-throughput immunoblotting (HTPI) technique, we reported changes in 29 out of 998 proteins following acute injuries to the rat brain (penetrating traumatic versus focal ischemic). Importantly, we discovered that one protein, endothelial monocyte-activating polypeptide II precursor (p43/pro-EMAPII), was differentially expressed between these two types of brain injury. Among other functions, p43/pro-EMAPII is a known pro-inflammatory cytokine involved in the progression of apoptotic cell death. Our current objective was to verify the changes in p43/pro-EMAPII expression, and to evaluate the potentially important implications that the differential regulation of this protein has on injury development. At multiple time points following either a penetrating ballistic-like brain injury (PBBI), or a transient middle cerebral artery occlusion (MCAo) brain injury, tissue samples (6-72 h), CSF samples (24 h), and blood samples (24 h) were collected from rats for analysis. Changes in protein expression were assessed by Western blot analysis and immunohistochemistry. Our results indicated that p43/pro-EMAPII was significantly increased in brain tissues, CSF, and plasma following PBBI, but decreased after MCAo injury compared to their respective sham control samples. This differential expression of p43/pro-EMAPII may be a useful injury-specific biomarker associated with the underlying pathologies of traumatic versus ischemic brain injury, and provide valuable information for directing injury-specific therapeutics. C1 [Dave, Jitendra R.] Walter Reed Army Inst Res, Div Psychiat & Neurosci, Dept Appl Neurobiol, Silver Spring, MD 20910 USA. [Ottens, Andrew K.] Virginia Commonwealth Univ, Richmond, VA USA. [Hayes, Ronald L.] Univ Florida, Dept Anesthesiol, Gainesville, FL USA. [Wang, Kevin K.] Univ Florida, Dept Psychiat, Gainesville, FL 32611 USA. [Liu, Ming Cheng; Hayes, Ronald L.; Wang, Kevin K.] Banyan Biomarkers Inc, Ctr Innovat Res, Alachua, FL USA. RP Dave, JR (reprint author), Walter Reed Army Inst Res, Div Psychiat & Neurosci, Dept Appl Neurobiol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM jit.dave@amedd.army.mil RI Ottens, Andrew/K-3352-2012; Dave, Jitendra/A-8940-2011; OI Wang, Kevin/0000-0002-9343-6473 FU Department of Defense [DAMD-03-1-0066]; NIH [R01NS04917501-A1] FX The authors thank Mrs. Christine Murphy for her critical comments and suggestions for improving the manuscript. The authors thank Mr. Zhilin Liao, Ms. Xiaofang Yang, S. P. C. Monika Torres, and SPC Franco Antinia for their excellent technical assistance in these studies. The authors would also like to acknowledge the support of Department of Defense grant DAMD-03-1-0066, and NIH grant R01NS04917501-A1. NR 28 TC 17 Z9 19 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD AUG PY 2009 VL 26 IS 8 BP 1295 EP 1305 DI 10.1089/neu.2008.0811 PG 11 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 479AF UT WOS:000268629900012 PM 19317603 ER PT J AU Balbir, A Lu, XC Tortella, F AF Balbir, Alexander Lu, Xi-Chun Tortella, Frank TI THE EFFECT OF TOPIRAMATE ON ELECTROENCEPHALOGRAPHY IN A MODEL OF PENETRATING BALLISTIC-TYPE BRAIN INJURY IN RATS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 2nd Joint Symposium of the National-and-International-Neurotrauma-Societies CY SEP 07-11, 2009 CL Santa Barbara, CA SP Natl & Int Neurotrauma Soc C1 [Balbir, Alexander; Lu, Xi-Chun; Tortella, Frank] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD AUG PY 2009 VL 26 IS 8 MA P112 BP A30 EP A30 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 479AF UT WOS:000268629900136 ER PT J AU Bowles, A Cooper, D DeVilbiss, C Rice, V AF Bowles, Amy Cooper, Douglas DeVilbiss, Carita Rice, Valerie TI CLINICAL CHARACTERISTICS OF OIF/OEF SERVICE MEMBERS WITH MILD AND MODERATE TRAUMATIC BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 2nd Joint Symposium of the National-and-International-Neurotrauma-Societies CY SEP 07-11, 2009 CL Santa Barbara, CA SP Natl & Int Neurotrauma Soc C1 [Bowles, Amy; Cooper, Douglas] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [DeVilbiss, Carita; Rice, Valerie] USA, Res Labs, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD AUG PY 2009 VL 26 IS 8 MA P87 BP A24 EP A24 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 479AF UT WOS:000268629900111 ER PT J AU Chen, ZY Lu, XCM Evangelista, C Duffy, D Tortella, F AF Chen, Zhiyong Lu, Xichun May Evangelista, Clifford Duffy, Danelle Tortella, Frank TI SYNERGISM OF HUMAN AMNION-DERIVED MULTIPOTENT PROGENITOR (AMP) CELLS AND A COLLAGEN SCAFFOLD IN PROMOTING BRAIN WOUND RECOVERY: PRE-CLINICAL STUDIES IN AN EXPERIMENTAL MODEL OF PBBI SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 2nd Joint Symposium of the National-and-International-Neurotrauma-Societies CY SEP 07-11, 2009 CL Santa Barbara, CA SP Natl & Int Neurotrauma Soc C1 [Chen, Zhiyong; Lu, Xichun May; Evangelista, Clifford; Tortella, Frank] Walter Reed Army Inst Res, Silver Spring, MD USA. [Duffy, Danelle] Stemnion Inc, Pittsburgh, PA USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD AUG PY 2009 VL 26 IS 8 MA P232 BP A60 EP A60 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 479AF UT WOS:000268629900253 ER PT J AU Davis, A Shear, D Chen, ZY Lu, XCM Tortella, F AF Davis, Angela Shear, Deborah Chen, Zhiyong Lu, Xi-Chun May Tortella, Frank TI A COMPARISON OF TWO COGNITIVE TEST PARADIGMS IN A MILITARY-RELEVANT TRAUMATIC BRAIN INJURY MODEL SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 2nd Joint Symposium of the National-and-International-Neurotrauma-Societies CY SEP 07-11, 2009 CL Santa Barbara, CA SP Natl & Int Neurotrauma Soc C1 [Davis, Angela; Shear, Deborah; Chen, Zhiyong; Lu, Xi-Chun May; Tortella, Frank] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD AUG PY 2009 VL 26 IS 8 MA P63 BP A18 EP A18 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 479AF UT WOS:000268629900088 ER PT J AU Garman, R Jenkins, LW Bauman, R Swauger, P Parks, S Switzer, R Dixon, CE Clark, RSB Bayir, H Kagan, V Jackson, EK Kochanek, PM AF Garman, Robert Jenkins, Larry W. Bauman, Richard Swauger, Peter Parks, Steven Switzer, Robert Dixon, C. Edward Clark, Robert S. B. Bayir, Huelya Kagan, Valerian Jackson, Edwin K. Kochanek, Patrick M. TI BLAST OVERPRESSURE INJURY IN RATS WITH BODY PROTECTION PRODUCES ACUTE AND SUB-ACUTE AXONAL, DENDRITIC AND SYNAPTIC NEUROPATHOLOGY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 2nd Joint Symposium of the National-and-International-Neurotrauma-Societies CY SEP 07-11, 2009 CL Santa Barbara, CA SP Natl & Int Neurotrauma Soc C1 [Jenkins, Larry W.; Dixon, C. Edward; Clark, Robert S. B.; Bayir, Huelya; Kochanek, Patrick M.] Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Pittsburgh, PA USA. [Garman, Robert] Vet Pathol Inc, Murrysville, PA USA. [Bauman, Richard] Walter Reed Army Inst Res, Silver Spring, MD USA. [Switzer, Robert] NeuroSci Associates, Knoxville, TN USA. [Kagan, Valerian] Pittsburgh Ctr Free Radical & Antioxidant Hlth, Pittsburgh, PA USA. [Jackson, Edwin K.] Ctr Clin Pharmacol, Pittsburgh, PA USA. RI Kochanek, Patrick/D-2371-2015 OI Kochanek, Patrick/0000-0002-2627-913X NR 0 TC 1 Z9 1 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD AUG PY 2009 VL 26 IS 8 MA P203 BP A53 EP A53 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 479AF UT WOS:000268629900225 ER PT J AU Lu, M Si, YZ Balbir, A Yang, XF Cao, Y Tortella, F AF Lu, May Si, Yuanzheng Balbir, Alexander Yang, Xiaofang Cao, Ying Tortella, Frank TI ANTIEPILEPTIC EFFECTS OF NEFIRACETAM ON NON-CONVULSIVE SEIZURES IN A RAT MODEL OF BRAIN ISCHEMIA SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 2nd Joint Symposium of the National-and-International-Neurotrauma-Societies CY SEP 07-11, 2009 CL Santa Barbara, CA SP Natl & Int Neurotrauma Soc C1 [Lu, May; Si, Yuanzheng; Balbir, Alexander; Yang, Xiaofang; Cao, Ying; Tortella, Frank] Walter Reed Army Inst Res, Silver Spring, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD AUG PY 2009 VL 26 IS 8 MA P244 BP A63 EP A63 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 479AF UT WOS:000268629900265 ER PT J AU Murakami, Y Lu, XCM Yang, XF Tortella, FC Wei, G AF Murakami, Yuki Lu, X. -C. May Yang, Xiaofang Tortella, Frank C. Wei, Guo TI REDUCTION OF BRAIN OXYGEN TENSION FOLLOWING PENETRATING BALLISTIC-LIKE BRAIN INJURY IN RATS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 2nd Joint Symposium of the National-and-International-Neurotrauma-Societies CY SEP 07-11, 2009 CL Santa Barbara, CA SP Natl & Int Neurotrauma Soc C1 [Murakami, Yuki; Lu, X. -C. May; Yang, Xiaofang; Tortella, Frank C.; Wei, Guo] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD AUG PY 2009 VL 26 IS 8 MA P79 BP A22 EP A22 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 479AF UT WOS:000268629900103 ER PT J AU Shear, D Lu, XC Tortella, F AF Shear, Deborah Lu, Xi-Chun Tortella, Frank TI DOSE RESPONSE PROFILE OF NA-1, A NOVEL PSD-95 BLOCKER, IN A MILITARY- RELEVANT MODEL OF PENETRATING BALLISTIC-LIKE BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 2nd Joint Symposium of the National-and-International-Neurotrauma-Societies CY SEP 07-11, 2009 CL Santa Barbara, CA SP Natl & Int Neurotrauma Soc C1 [Shear, Deborah; Lu, Xi-Chun; Tortella, Frank] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD AUG PY 2009 VL 26 IS 8 MA P97 BP A26 EP A26 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 479AF UT WOS:000268629900120 ER PT J AU Shear, D Pedersen, R Bombard, M Lu, XC Tortella, F AF Shear, Deborah Pedersen, Rebecca Bombard, Matthew Lu, Xi-Chun Tortella, Frank TI LONGITUDINAL CHARACTERIZATION OF COGNITIVE DEFICITS IN AN EXPERIMENTAL MODEL OF PENETRATING BALLISTIC-LIKE BRAIN INJURY USING THE MORRIS WATER MAZE SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 2nd Joint Symposium of the National-and-International-Neurotrauma-Societies CY SEP 07-11, 2009 CL Santa Barbara, CA SP Natl & Int Neurotrauma Soc C1 [Shear, Deborah; Pedersen, Rebecca; Bombard, Matthew; Lu, Xi-Chun; Tortella, Frank] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD AUG PY 2009 VL 26 IS 8 MA P67 BP A19 EP A19 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 479AF UT WOS:000268629900091 ER PT J AU Svetlov, S Prima, V Kirk, D Atkinson, J Gutierrez, H Curley, K Hayes, R Wang, K AF Svetlov, Stanislav Prima, Victor Kirk, Daniel Atkinson, Joseph Gutierrez, Hector Curley, Kenneth Hayes, Ronald Wang, Kevin TI MORPHOLOGICAL AND BIOCHEMICAL SIGNATURES OF BRAIN INJURY FOLLOWING HEAD-DIRECTED CONTROLLED BLAST OVERPRESSURE IMPACT SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 2nd Joint Symposium of the National-and-International-Neurotrauma-Societies CY SEP 07-11, 2009 CL Santa Barbara, CA SP Natl & Int Neurotrauma Soc C1 [Svetlov, Stanislav; Prima, Victor; Hayes, Ronald; Wang, Kevin] Banyan Biomarkers Inc, Alachua, FL USA. [Kirk, Daniel; Atkinson, Joseph; Gutierrez, Hector] Florida Inst Technol, Melbourne, FL 32901 USA. [Curley, Kenneth] USA, Med Res & Mat Command, Ft Detrick, MD USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD AUG PY 2009 VL 26 IS 8 MA P291 BP A75 EP A75 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 479AF UT WOS:000268629900310 ER PT J AU Teranishi, K Chavko, M Adeeb, S Carroll, E Mccarron, R AF Teranishi, Kohsuke Chavko, Mikulas Adeeb, Saleena Carroll, Erica Mccarron, Richard TI BLAST-INDUCED NEUROPATHOLOGICAL CHANGES IN BRAIN IN RELATION TO DIFFERENT ORIENTATION TO BLAST SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 2nd Joint Symposium of the National-and-International-Neurotrauma-Societies CY SEP 07-11, 2009 CL Santa Barbara, CA SP Natl & Int Neurotrauma Soc C1 [Teranishi, Kohsuke; Chavko, Mikulas; Adeeb, Saleena; Mccarron, Richard] USN, Med Res Ctr, Silver Spring, MD USA. [Carroll, Erica] Walter Reed Army Inst Res, Silver Spring, MD USA. [Teranishi, Kohsuke] Juntendo Grad Sch Med, Dept Neurosurg, Tokyo, Japan. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD AUG PY 2009 VL 26 IS 8 MA P11 BP A4 EP A4 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 479AF UT WOS:000268629900036 ER PT J AU Wei, G Yang, XF Tortella, FC Lu, XCM AF Wei, Guo Yang, Xiaofang Tortella, Frank C. Lu, Xi-Chun M. TI EFFECT OF SELECTIVE BRAIN COOLING ON ACUTE NEUROPATHOGICAL CHANGES FOLLOWING PENETRATING BALLISTIC-LIKE BRAIN INJURY IN RATS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 2nd Joint Symposium of the National-and-International-Neurotrauma-Societies CY SEP 07-11, 2009 CL Santa Barbara, CA SP Natl & Int Neurotrauma Soc C1 [Wei, Guo; Yang, Xiaofang; Tortella, Frank C.; Lu, Xi-Chun M.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD AUG PY 2009 VL 26 IS 8 MA P227 BP A59 EP A59 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 479AF UT WOS:000268629900247 ER PT J AU Crane, DP Gromov, K Li, D Soballe, K Wahnes, C Buchner, H Hilton, MJ O'Keefe, RJ Murray, CK Schwarz, EM AF Crane, Daniel P. Gromov, Kirill Li, Dan Soballe, Kjeld Wahnes, Christian Buechner, Hubert Hilton, Matthew J. O'Keefe, Regis J. Murray, Clinton K. Schwarz, Edward M. TI Efficacy of colistin-Impregnated Beads to Prevent Multidrug-Resistant A. baumannii Implant-Associated Osteomyelitis SO JOURNAL OF ORTHOPAEDIC RESEARCH LA English DT Article DE multidrug resistant; Acinetobacter baumannii; osteomyelitis; colistin ID OPERATION ENDURING FREEDOM; ACINETOBACTER-BAUMANNII; ADHERENT ENDOTOXIN; TITANIUM PARTICLES; IRAQI FREEDOM; UNITED-STATES; INFECTIONS; BONE; DIFFERENTIATION; MANAGEMENT AB Osteomyelitis (OM) from multidrug-resistant (MDR) Acinetobacter has emerged in >30% of combat-related injuries in Iraq and Afghanistan. While most of these strains are sensitive to colistin, the drug is not available in bone void fillers for local high-dose delivery. To address this, we developed a mouse model with MDR strains isolated from wounded military personnel. In contrast to S. aureus OM, which is osteolytic and characterized by biofilm in necrotic bone, A. baumannii OM results in blastic lesions that do not contain apparent biofilm. We also found that mice mount a specific IgG response against three proteins (40, 47, and 56 kDa) regardless of the strain used, suggesting that these may be immuno-dominant antigens. PCR for the A. baumannii-specific parC gene confirmed a 100% infection rate with 75% of the MDR strains, and in vitro testing con firmed that all strains were sensitive to colistin. We also developed a real-time quantitative PCR (RTQ-PCR) assay that could detect as few as 10 copies of parC in a sample. To demonstrate the efficacy of colistin prophylaxis in this model, mice were treated with either parenteral colistin (0.2 mg colistinmethate i.m. for 7 days), local colistin (PMMA bead impregnated with 1.0 mg colistin sulfate), or an unloaded PMMA bead control. While the parenteral colistin failed to demonstrate any significant effects versus the placebo, the colistin PMMA bead significantly reduced the infection rate such that only 29.2% of the mice had detectable levels of parC at 19 days (p < 0.05 vs. i.m. colistin and placebo). (C) 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.(dagger) J Orthop Res 27:1008-1015, 2009 C1 [Crane, Daniel P.; Gromov, Kirill; Li, Dan; Hilton, Matthew J.; O'Keefe, Regis J.; Schwarz, Edward M.] Univ Rochester, Med Ctr, Ctr Musculoskeletal Res, Rochester, NY 14642 USA. [Gromov, Kirill; Soballe, Kjeld] Aarhus Univ Hosp, Dept Orthoped, DK-8000 Aarhus, Denmark. [Wahnes, Christian; Buechner, Hubert] Heraeus Med GmbH, Res & Dev, Wehrheim, Germany. [Murray, Clinton K.] Brooke Army Med Ctr, Dept Med, Infect Dis Serv, San Antonio, TX USA. RP Schwarz, EM (reprint author), Univ Rochester, Med Ctr, Ctr Musculoskeletal Res, 601 Elmwood Ave,Box 665, Rochester, NY 14642 USA. EM Edward_Schwarz@URMC.Rochester.edu OI Hilton, Matthew/0000-0003-3165-267X FU US Army Medical Research Acquisition Activity (USAMRAA); Orthopaedic Trauma Research Program (OTRP) [W81XWH-07-1-0124]; National Institutes of Health [AR48681, DE17096, AR52674, AR51469, AR46545, AR54041, AR53459] FX The authors thank Laura Yanoso for technical assistance with the micro-CT, and Krista Scorsone for technical assistance with the histology. This work was supported by research grants from the US Army Medical Research Acquisition Activity (USAMRAA), Orthopaedic Trauma Research Program (OTRP) W81XWH-07-1-0124, and the National Institutes of Health PHS awards AR48681, DE17096, AR52674, AR51469, AR46545, AR54041, and AR53459. NR 37 TC 20 Z9 21 U1 0 U2 1 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0736-0266 J9 J ORTHOP RES JI J. Orthop. Res. PD AUG PY 2009 VL 27 IS 8 BP 1008 EP 1015 DI 10.1002/jor.20847 PG 8 WC Orthopedics SC Orthopedics GA 468UK UT WOS:000267848200005 PM 19173261 ER PT J AU Koppenhaver, SL Parent, EC Teyhen, DS Hebert, JJ Fritz, JM AF Koppenhaver, Shane L. Parent, Eric C. Teyhen, Deydre S. Hebert, Jeffrey J. Fritz, Julie M. TI The Effect of Averaging Multiple Trials on Measurement Error During Ultrasound Imaging of Transversus Abdominis and Lumbar Multifidus Muscles in Individuals With Low Back Pain SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE abdominal muscles; lumbar spine; reliability; ultrasonography ID DISC HERNIATION; DRAWING-IN; RELIABILITY; CONTRACTION; RECRUITMENT; INTRARATER; MOVEMENT; VALIDITY; PEOPLE; INDEX AB STUDY DESIGN: Clinical measurement, reliability study. OBJECTIVES: To investigate the improvements in precision when averaging multiple measurements of percent change in muscle thickness of the transversus abdominis (TrA) and lumbar multifidus (LM) muscles. BACKGROUND: Although the reliability of TrA and LM muscle thickness measurements using rehabilitative ultrasound imaging (RUSI) is good, measurement error is often large relative to mean muscle thickness. Additionally, percent thickness change measures incorporate measurement error from both resting and contracted conditions. METHODS: Thirty volunteers with nonspecific low back pain participated. Thickness measurements of the TrA and LM muscles were obtained using RUSI at rest and during standardized tasks. Percent thickness change was calculated with the formula (thickness(contracted)-thickness(rest)/thickness(rest)). Standard error of measurement (SEM) quantified precision when using 1 or a mean of 2 to 6 consecutive measurements. RESULTS: Compared to when using a single measurement, SEM of both the TrA and LM decreased by nearly 25% when using a mean of 2 measures, and by 50% when using the mean of 3 measures. Little precision was gained by averaging more than 3 measurements. CONCLUSION: When using RUSI to determine percent change in TrA and LM muscle thickness, intraexaminer measurement precision appears to be optimized by using an average of 3 consecutive measurements. J Orthop Sport Phys Ther 2009;39(8):604-611. doi:10.2519/jospt.2009.3088 C1 [Koppenhaver, Shane L.; Hebert, Jeffrey J.; Fritz, Julie M.] Univ Utah, Coll Hlth, Salt Lake City, UT USA. [Parent, Eric C.] Univ Alberta, Dept Phys Therapy, Edmonton, AB, Canada. [Parent, Eric C.] Glenrose Rehabil Hosp, Edmonton, AB, Canada. [Teyhen, Deydre S.] Baylor Univ, USA, Doctoral Program Phys Therapy, San Antonio, TX USA. [Hebert, Jeffrey J.] Univ Utah, Dept Neurosurg, Salt Lake City, UT USA. [Fritz, Julie M.] Intermt Hlth Care, Salt Lake City, UT USA. RP Koppenhaver, SL (reprint author), 1416 Downington Ave, Salt Lake City, UT 84105 USA. EM shanekoppenhaver@mac.com RI Hebert, Jeffrey/C-4614-2008 OI Hebert, Jeffrey/0000-0002-6959-325X NR 33 TC 46 Z9 47 U1 2 U2 13 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD AUG PY 2009 VL 39 IS 8 BP 604 EP 611 DI 10.2519/jospt.2009.3088 PG 8 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 482BZ UT WOS:000268859900004 PM 19648721 ER PT J AU Mahanonda, R Sa-Ard-Iam, N Eksomtramate, M Rerkyen, P Phairat, B Schaecher, KE Fukuda, MM Pichyangkul, S AF Mahanonda, R. Sa-Ard-Iam, N. Eksomtramate, M. Rerkyen, P. Phairat, B. Schaecher, K. E. Fukuda, M. M. Pichyangkul, S. TI Cigarette smoke extract modulates human beta-defensin-2 and interleukin-8 expression in human gingival epithelial cells SO JOURNAL OF PERIODONTAL RESEARCH LA English DT Article DE cigarette smoke extract; human gingival epithelium; human beta-defensin-2; interleukin-8; periodontal disease ID TOLL-LIKE RECEPTORS; BACTERIAL LIPOPOLYSACCHARIDE; PORPHYROMONAS-GINGIVALIS; ANTIMICROBIAL PEPTIDES; PERIODONTAL-DISEASE; ENDOTHELIAL-CELLS; TOBACCO SMOKING; RISK INDICATORS; BETA-DEFENSINS; FIBROBLASTS AB Background and Objective: Human gingival epithelial cells (HGECs) are continually exposed to oral bacteria and to other harmful agents. Their responses to stimuli are critical in maintaining periodontal homeostasis. The aim of this study was to investigate the modulating effect of cigarette smoke extract (CSE) on the innate immune responses of HGECs. Material and Methods: Toll-like receptor (TLR) expression of HGECs was determined by reverse transcriptase-polymerase chain reaction (RT-PCR). The effect of CSE or nicotine on the expression of the antimicrobial peptide human beta-defensin-2 (hBD-2) and the pro-inflammatory cytokine interleukin (IL)-8 in stimulated HGEC cultures was evaluated by RT-PCR and enzyme-linked immunosorbent assay. Results: The HGECs expressed mRNA of TLRs 1, 2, 3, 5, 6, 9, 10, and minimally of TLR4, but not of TLRs 7 or 8. Stimulation of HGECs with highly purified TLR2, 3 or 5 ligands led to expression of hBD-2 and of IL-8. Enhancement of hBD-2 and IL-8 was observed in HGECs after combined stimulation with Porphyromonas gingivalis lipopolysaccharide (TLR2 ligand) and tumour necrosis factor-alpha, compared with stimulation using either agent alone. After CSE exposure, hBD-2 expression was markedly reduced in stimulated HGEC cultures, whereas IL-8 expression was markedly increased. These effects were also observed, but were markedly attenuated, upon nicotine treatment. Conclusion: Human gingival epithelial cells play a critical role in orchestrating the innate immune responses of periodontal tissue via TLR signalling. Our results represent the first demonstration that CSE can modulate HGEC function by suppressing hBD-2 and enhancing IL-8 production, and this may be, in part, a possible mechanism which promotes periodontal disease. C1 [Mahanonda, R.] Chulalongkorn Univ, Dept Periodontol, Fac Dent, Res Unit Periodontal Dis, Bangkok 10330, Thailand. [Schaecher, K. E.; Fukuda, M. M.; Pichyangkul, S.] Armed Forces Res Inst Med Sci, US Army Med Component, Dept Immunol & Med, Bangkok 10400, Thailand. [Sa-Ard-Iam, N.; Rerkyen, P.] Chulalongkorn Univ, Immunol Lab, Fac Dent, Bangkok 10330, Thailand. RP Mahanonda, R (reprint author), Chulalongkorn Univ, Dept Periodontol, Fac Dent, Res Unit Periodontal Dis, Henry Dunant Rd, Bangkok 10330, Thailand. EM mrangsin@chula.ac.th FU Chulalongkorn University Fund; Government Research Budget [GRB_02_50_32_02] FX This work was supported by Thai Health Grant, the 90th Anniversary of Chulalongkorn University Fund (Ratchadaphiseksomphot Endowment Fund) and the Government Research Budget (GRB_02_50_32_02). We thank Dr Kitti Torrungruang and Dr Kanokwan Nisapakultorn for their technical assistance. NR 38 TC 37 Z9 39 U1 0 U2 1 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0022-3484 J9 J PERIODONTAL RES JI J. Periodont. Res. PD AUG PY 2009 VL 44 IS 4 BP 557 EP 564 DI 10.1111/j.1600-0765.2008.01153.x PG 8 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 463IZ UT WOS:000267426900018 PM 19438974 ER PT J AU Getchis, T Rose, CM Carey, D Kelly, S Bellantuono, K AF Getchis, Tessa Rose, Cori M. Carey, David Kelly, Shannon Bellantuono, Kristen TI REGULATORY GUIDANCE FOR AQUACULTURE PRODUCERS AND INDIVIDUALS CONDUCTING RESEARCH WITH AQUATIC ORGANISMS IN CONNECTICUT SO JOURNAL OF SHELLFISH RESEARCH LA English DT Meeting Abstract C1 [Getchis, Tessa] Univ Connecticut, Sea Grant Extens Program, Groton, CT 06340 USA. [Rose, Cori M.] US Army Crops Engineers, Concord, MA 01742 USA. [Carey, David; Kelly, Shannon] Bur Aquaculture, Connecticut Dept Agr, Milford, CT 06460 USA. [Bellantuono, Kristen] Connecticut Dept Environm Protect, Off Long Isl Sound Programs, Hartford, CT 06106 USA. EM tessa.getchis@uconn.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATL SHELLFISHERIES ASSOC PI GROTON PA C/O DR. SANDRA E. SHUMWAY, UNIV CONNECTICUT, 1080 SHENNECOSSETT RD, GROTON, CT 06340 USA SN 0730-8000 J9 J SHELLFISH RES JI J. Shellfish Res. PD AUG PY 2009 VL 28 IS 3 BP 649 EP 650 PG 2 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA 546HK UT WOS:000273801700041 ER PT J AU Rafuse, ES AF Rafuse, Ethan S. TI Unfurl Those Colors! McClellan, Sumner, and the Second Army Corps in the Antietam Campaign. SO JOURNAL OF SOUTHERN HISTORY LA English DT Book Review C1 [Rafuse, Ethan S.] USA, Command & Gen Staff Coll, Washington, DC 20310 USA. RP Rafuse, ES (reprint author), USA, Command & Gen Staff Coll, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOUTHERN HISTORICAL ASSOC PI ATHENS PA UNIV GEORGIA, HISTORY DEPT, ATHENS, GA 30602 USA SN 0022-4642 J9 J SOUTHERN HIST JI J. South. Hist. PD AUG PY 2009 VL 75 IS 3 BP 812 EP 813 PG 2 WC History SC History GA 477YG UT WOS:000268554300055 ER PT J AU Lee, MS Lebeda, FJ Olson, MA AF Lee, Michael S. Lebeda, Frank J. Olson, Mark A. TI Fold prediction of VP24 protein of Ebola and Marburg viruses using de novo fragment assembly SO JOURNAL OF STRUCTURAL BIOLOGY LA English DT Article DE De novo fragment assembly; Rosetta; Fold recognition; Ebola; Marburg; Hemorrhagic fever virus; VP24; Importin; Exportin ID C-TERMINAL DOMAIN; SECONDARY STRUCTURE; IMPORTIN-ALPHA; DISTANT HOMOLOGY; DATABASE; NUCLEOPROTEIN; TRANSCRIPTION; POTENTIALS; REFINEMENT; SEQUENCES AB Virus particle 24 (VP24) is the smallest protein of the Ebola and Marburg virus genomes. Recent experiments show that Ebola VP24 blocks binding of tyrosine-phosphorylated STAT-1 homodimer (PY-STAT1) to the NPI-1 subfamily of importin alpha, thereby preventing nuclear accumulation of this interferon-promoting transcription factor which, in turn, reduces the innate immune response of the host target. Lacking an experimental structure for VP24, we applied de novo protein structure prediction using the fragment assembly-based Rosetta method to classify its fold topology and better understand its biological function. Filtering and ranking of models were performed with the DFIRE all-atom statistical potential and the CHARMM22 force field with a generalized Born solvent model. From 40,000 Rosetta-generated structures and selective comparisons with the SCOP database, a structural match to two of our top 10-ranking models was the Armadillo repeat fold topology. Specific members of this fold family include importin alpha, importin beta, and exportin. We propose that, unlike the nuclear import of host cargo, VP24 lacks a classical nuclear localization signal (NLS) and targets importin alpha in a similar manner to the observed heterodimeric complex with exportin, thereby interfering with the auto-inhibitory NLS on importin alpha and blocking peripheral docking sites for PY-STAT1 assembly. Published by Elsevier Inc. C1 [Lee, Michael S.; Lebeda, Frank J.; Olson, Mark A.] USA, Med Res Inst Infect Dis, Dept Cell Biol & Biochem, Frederick, MD 21702 USA. [Lee, Michael S.] USA, Res Lab, Computat Sci & Engn Branch, Aberdeen Proving Ground, MD 21005 USA. RP Lee, MS (reprint author), USA, Med Res Inst Infect Dis, Dept Cell Biol & Biochem, Frederick, MD 21702 USA. EM michael.lee@amedd.army.mil FU DoD Defense Threat Reduction Agency [DTRA 4.1001107_RD_B]; Computational Biology program of the DoD Advanced Research Project Agency [DARPA 05-0-DA-008]; Department of Defense High Performance Computing Modernization Program Office (HPCMO); Biotechnology High Performance Computing Software Applications Institute (BHSAI) FX We thank Drs. S. Bavari, R. Harty, A. Wallqvist, and K. Erickson for helpful discussions. Financial support for this work comes from DoD Defense Threat Reduction Agency grant (DTRA 4.1001107_RD_B to MAO), from the Computational Biology program of the DoD Advanced Research Project Agency (DARPA 05-0-DA-008 to FJL) and from the Department of Defense High Performance Computing Modernization Program Office (HPCMO) and the Biotechnology High Performance Computing Software Applications Institute (BHSAI) to MSL. We thank the Army Research Laboratory DoD Supercomputing Resource Center for computer time. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the US Army or of the US Department of Defense. This paper has been approved for public release with unlimited distribution. NR 50 TC 9 Z9 9 U1 0 U2 11 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1047-8477 J9 J STRUCT BIOL JI J. Struct. Biol. PD AUG PY 2009 VL 167 IS 2 BP 136 EP 144 DI 10.1016/j.jsb.2009.05.001 PG 9 WC Biochemistry & Molecular Biology; Biophysics; Cell Biology SC Biochemistry & Molecular Biology; Biophysics; Cell Biology GA 473HG UT WOS:000268196300005 PM 19447180 ER PT J AU Gates, JD Benavides, LC Shriver, CD Peoples, GE Stojadinovic, A AF Gates, Jeremy D. Benavides, Linda C. Shriver, Craig D. Peoples, George E. Stojadinovic, Alexander TI Preoperative Thyroid Ultrasound In All Patients Undergoing Parathyroidectomy? SO JOURNAL OF SURGICAL RESEARCH LA English DT Article; Proceedings Paper CT 3rd Annual Academic Surgical Congress CY FEB 12-15, 2008 CL Huntington Beach, CA SP Assoc Acad Surg, Soc Univ Surg DE hyperparathyroidism; sestamibi; ultrasound; thyroid; disease ID ASYMPTOMATIC PRIMARY HYPERPARATHYROIDISM; DISEASE; CANCER; PERSPECTIVE AB Background. Coexisting thyroid nodules are the most common cause of false positive localization by radioscintigraphy in the preoperative evaluation for NEWS in patients with primary hyperparathyroidism (pHPT). This false positive finding can prompt full neck exploration in the setting of an unanticipated and incompletely evaluated thyroid nodule. Therefore, we are studying prospectively the routine use of preoperative thyroid US in patients with pHPT to determine the prevalence of concurrent thyroid disease and to assess how frequently this added information could alter the surgical plan. Materials and Methods. Twenty-four patients with biochemically confirmed pHPT were evaluated with thyroid US after localizing (99m)Tc-sestamibi scintigraphy prior to parathyroid operation. Results. Of the 24 patients, 38% (n = 9) had their operations altered from a planned NEWS or four-gland exploration due to coexisting thyroid nodule(s). Of these, 33% (n = 3) had underlying thyroid malignancy (all papillary thyroid cancer) requiring thyroidectomy in addition to parathyroidectomy. All but one patient had parathyroid adenoma as the cause of pHPT. Conclusion. The routine use of preoperative thyroid US in patients with pHPT undergoing parathyroid surgery may aid in the timely diagnosis and treatment of coexisting thyroid disease. This added information secured before operation may avoid difficult intraoperative decision dilemmas and prevent the increased morbidity associated with a second neck exploration. A large scale prospective study is ongoing. Published by Elsevier Inc. C1 [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Gen Surg Serv, Washington, DC 20307 USA. [Gates, Jeremy D.; Benavides, Linda C.; Peoples, George E.] Brooke Army Med Ctr, Dept Surg, Gen Surg Serv, Ft Sam Houston, TX 78234 USA. [Peoples, George E.; Stojadinovic, Alexander] Univ Hlth Sci, Uniformed Serv, Dept Surg, Canc Vaccine Dev Program,US Mil Canc Inst, Bethesda, MD USA. RP Stojadinovic, A (reprint author), Walter Reed Army Med Ctr, Dept Surg, Gen Surg Serv, Washington, DC 20307 USA. EM alexander.stojadinovic@amedd.army.mil NR 19 TC 15 Z9 16 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 J9 J SURG RES JI J. Surg. Res. PD AUG PY 2009 VL 155 IS 2 BP 254 EP 260 DI 10.1016/j.jss.2008.09.012 PG 7 WC Surgery SC Surgery GA 488EP UT WOS:000269332300012 PM 19482296 ER PT J AU Shoop, S Lee, JH AF Shoop, Sally Lee, Jonah H. TI Special Issue on Snow Mobility SO JOURNAL OF TERRAMECHANICS LA English DT Editorial Material C1 [Shoop, Sally] USA, Ctr Res Dev & Engn, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Lee, Jonah H.] Univ Alaska, Fairbanks, AK 99775 USA. RP Shoop, S (reprint author), USA, Ctr Res Dev & Engn, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM sally.a.shoop@usace.army.mil; ffjhl@uaf.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 J9 J TERRAMECHANICS JI J. Terramech. PD AUG PY 2009 VL 46 IS 4 BP 125 EP 126 DI 10.1016/j.jterra.2009.06.005 PG 2 WC Engineering, Environmental SC Engineering GA 491NE UT WOS:000269585000001 ER PT J AU Parker, MW Shoop, SA Coutermarsh, BA Wesson, KD Stanley, JM AF Parker, Michael W. Shoop, Sally A. Coutermarsh, Barry A. Wesson, Kyle D. Stanley, Jesse M. TI Verification and validation of a winter driving simulator SO JOURNAL OF TERRAMECHANICS LA English DT Article CT Joint North America and Asia-Pacific ISTVS Conference/Annual Meeting of the Japanese-Society-for-Terramechanics CY JUN 23-26, 2007 CL Fairbanks, AK SP Japanese Soc Terrmechan, Int Soc Terrain Vehicle Syst AB A full vehicle dynamics simulator was constructed in SimCreator (R) for the Cold Regions Research and Engineering Laboratory (CRREL) Instrumented Vehicle (CIV) and was used to investigate and validate the newly developed Vehicle Terrain Interaction (VTI) code. The VTI code replaces the tire component of the simulated vehicle, in the Driver and Motion Simulator (DMS), allowing it to report back realistic values while driving oil various types of terrain surfaces such as mud, snow, ice, and pavement. The validation effort within this paper is focused oil the winter (snow and ice) parts of the VTI code. The outputs from the Engineering Research and Development Center (ERDC) and the DMS VTI codes were validated through field experiments and against the North Atlantic Treaty Organization (NATO) Reference Mobility Model (NRMM). The DMS VTI code can be used with different vehicle models, providing the US. Army with a valuable asset that will allow simulation of existing or conceptual, manned or autonomous, ground vehicle performance for acquisition, planning, or training. This information, along with some basic terrain information, will allow troops to plan the fastest and most effective way of getting to a desired location, while minimizing the possibility of being delayed because of the terrain conditions. Published by Elsevier Ltd on behalf of ISTVS. C1 [Parker, Michael W.; Shoop, Sally A.; Coutermarsh, Barry A.; Wesson, Kyle D.; Stanley, Jesse M.] CRREL, Erdc, Hanover, NH 03755 USA. RP Parker, MW (reprint author), CRREL, Erdc, 72 Lyme Rd, Hanover, NH 03755 USA. EM Michael.W.Parker@usace.army.mil; Sally.A.Shoop@usace.army.mil; Barry.A.Coutermarsh@usace.army.mil; Kyle.D.Wesson@usace.army.mil; Jesse.M.Stanley@usace.army.mil NR 8 TC 6 Z9 8 U1 0 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 J9 J TERRAMECHANICS JI J. Terramech. PD AUG PY 2009 VL 46 IS 4 BP 127 EP 139 DI 10.1016/j.jterra.2009.05.002 PG 13 WC Engineering, Environmental SC Engineering GA 491NE UT WOS:000269585000002 ER PT J AU Coutermarsh, BA Shoop, SA AF Coutermarsh, Barry A. Shoop, Sally A. TI Tire slip-angle force measurements on winter surfaces SO JOURNAL OF TERRAMECHANICS LA English DT Article CT Joint North America and Asia-Pacific ISTVS Conference/Annual Meeting of the Japanese-Society-for-Terramechanics CY JUN 23-26, 2007 CL Fairbanks, AK SP Japanese Soc Terrmechan, Int Soc Terrain Vehicle Syst AB Tire lateral force data on winter surfaces cannot be obtained with the traditional laboratory test technique of an instrumented tire on a moving belt surface. Furthermore, changing snow and ice conditions can drastically change the tire/surface interaction. In this study the Cold Regions Research and Engineering Laboratory's (CRREL's) Instrumented Vehicle (CIV) was used in a unique configuration to measure tire lateral force versus slip-angle data on ice and snow at various temperatures, moisture contents, depths, and densities. The vehicle is instrumented to record longitudinal, lateral, and vertical force at the tire contact patch of each wheel as well as vehicle speed, tire speed, and front tire slip angle. The tests were conducted at the Keweenaw Research Center (KRC) in northern Michigan in February 2005 and March 2006. Tests were conducted on ice, packed snow from 0.50 to 0.58 g/cc, remixed snow depths of 2.5-20.3 cm at 0.43 to 0.48 g/cc and freshly fallen snow with depths of 0.5-17 cm at 0.07 to 0.23 g/cc. Surface air temperatures during testing ranged from -14 to 1.6 degrees C. The data collected show that peak lateral force and the shape of the lateral force versus slip-angle curve arc related to snow properties and depths. Published by Elsevier Ltd on behalf of ISTVS. C1 [Coutermarsh, Barry A.; Shoop, Sally A.] USACRREL, Hanover, NH 03755 USA. RP Coutermarsh, BA (reprint author), USACRREL, 72 Lyme Rd, Hanover, NH 03755 USA. EM barry@crrel.usace.army.mil; Sally.A.Shoop@erdc.usace.army.mil NR 4 TC 6 Z9 6 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 J9 J TERRAMECHANICS JI J. Terramech. PD AUG PY 2009 VL 46 IS 4 BP 157 EP 163 DI 10.1016/j.jterra.2008.08.002 PG 7 WC Engineering, Environmental SC Engineering GA 491NE UT WOS:000269585000004 ER PT J AU Affleck, RT Melloh, RA Shoop, SA AF Affleck, Rosa T. Melloh, Rae A. Shoop, Sally A. TI Cross-country mobility on various snow conditions for validation of a virtual terrain SO JOURNAL OF TERRAMECHANICS LA English DT Article CT Joint North America and Asia-Pacific ISTVS Conference/Annual Meeting of the Japanese-Society-for-Terramechanics CY JUN 23-26, 2007 CL Fairbanks, AK SP Japanese Soc Terrmechan, Int Soc Terrain Vehicle Syst AB Realistic simulation of on-and off-road vehicle performance in all weather conditions is needed by the U.S. Army for virtual training of personnel oil existing vehicles, and for new vehicle design. The virtual test site is a computer simulation representing an actual terrain defined as having spatially distributed terramechanics properties and terrain interaction with vehicles. We developed a virtual test site for Ethan Allen Firing Range (EAFR) in northern Vermont. The virtual test site for EAFR is composed of terramechanics properties including spatially distributed snow depth and density, soil type, drainage class, slope, and vegetation type. Snow depth and density were spatially distributed with regard to elevation, slope, and aspect using a surface energy balance approach. This paper evaluates whether the terramechanics representation of a virtual test site is improved by adding spatially distributed snow and soil properties, rather than using uniform properties. The evaluation was accomplished by conducting a cross-country vehicle performance analysis using the North Atlantic Treaty Organization (NATO) Reference Mobility Model (NRMM) to validate the new algorithms for realistic spatial distribution of snow properties. The results showed that the percentage of No-Go areas for uniform snow is lower than the distributed snow by 4% for the CIV (CRREL Instrumented Vehicle), 8% for the HMMWV (High Mobility Multipurpose Wheeled Vehicle), and 5% for the Stryker vehicle. For both light vehicles, approximately 12% of the No-Go areas are classified as such because of slopes >= 29%. These results imply that spatial distribution of snow properties provides realistic vehicle response as opposed to having the snow properties distributed uniformly throughout the entire terrain. This represents ail improvement over previous versions of the terramechanics properties. (C) 2009 ISTVS. Published by Elsevier Ltd. All rights reserved. C1 [Affleck, Rosa T.; Melloh, Rae A.; Shoop, Sally A.] USA, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Affleck, RT (reprint author), USA, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Rosa.T.Affleck@erdc.usace.army.mil; Rae.A.Melloh@erdc.usace.army.mil; Sally.A.Shoop@erdc.usace.army.mil NR 14 TC 1 Z9 1 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 J9 J TERRAMECHANICS JI J. Terramech. PD AUG PY 2009 VL 46 IS 4 BP 203 EP 210 DI 10.1016/j.jterra.2008.12.005 PG 8 WC Engineering, Environmental SC Engineering GA 491NE UT WOS:000269585000007 ER PT J AU Edens, JW Beekley, AC Chung, KK Cox, ED Eastridge, BJ Holcomb, JB Blackbourne, LH AF Edens, Jason W. Beekley, Alec C. Chung, Kevin K. Cox, E. Darrin Eastridge, Brian J. Holcomb, John B. Blackbourne, Lorne H. TI Longterm Outcomes after Combat Casualty Emergency Department Thoracotomy SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Article ID OPERATION-IRAQI-FREEDOM; RESUSCITATIVE THORACOTOMY; ROOM THORACOTOMY; SURGICAL MANAGEMENT; TRAUMA; EXPERIENCE; INJURIES; SURVIVAL; MORTALITY; WOUNDS AB BACKGROUND: The incidence, survival, and blood product use after emergency department thoracotomy (EDT) in combat casualties is unknown. STUDY DESIGN: We performed a prospective and retrospective observational study of EDT at a combat support hospital in Iraq, evaluating the impact of injury mechanisms, blood product use, mortality, and longterm neurologic outcomes of survivors. RESULTS: From November 2003 to December 2007, 12,536 trauma admissions resulted in 101 EDTs (0.01%). In patients undergoing EDT, penetrating trauma from explosions and firearms accounted for the majority of injuries (93%). There were no survivors after EDT for blunt trauma (n = 7). The areas Of primary penetrating injury were the abdomen (30%), thorax (40%), and extremities (22%). Twelve percent (12 of 10 1) of all patients survived until evacuation, with the overall survival rate (8 to 26 months) of US casualties at 11% (6 of 53). There was no difference in survival seen in either injury mechanism or primary injury location. Signs of life were present in all overall survivors. Cardiopulmonary resuscitation (CPR) was performed in 92% (93 of 101) of all patients, and in 75% (9 of 12) of those evacuated. Mean (+/- SD) transfusion requirements for all patients were 15.0 +/- 12.7 U of RBC and 7.3 +/- 8.7 U of fresh frozen plasma during the initial resuscitation. Survivors demonstrated higher fresh frozen plasma:RBC ratios. All survivors were neurologically intact. CONCLUSIONS: In the combat casualty with penetrating injury, arriving with signs of life, receiving CPR, and undergoing EDT, longterm survival with normal neurologic Outcomes Is possible. CPR is not a contraindication to performance of EDT in penetrating injuries if signs of life are present. A large amount of blood products are used in the resuscitation of EDT patients. (J Am Coll Surg 2009;209:188-197. (C) 2009 by the American College Of Surgeons) C1 [Edens, Jason W.; Chung, Kevin K.; Eastridge, Brian J.; Holcomb, John B.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Beekley, Alec C.] Madigan Army Med Ctr, Dept Gen Surg, Ft Lewis, WA USA. [Cox, E. Darrin] 745th Forward Surg Team, Ft Bliss, TX USA. RP Blackbourne, LH (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. NR 37 TC 23 Z9 23 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD AUG PY 2009 VL 209 IS 2 BP 188 EP 197 DI 10.1016/j.jamcollsurg.2009.03.023 PG 10 WC Surgery SC Surgery GA 480PC UT WOS:000268747300005 PM 19632595 ER PT J AU Seery, JM Valosen, JM Phillips, JH Slade, DL Seery, AB Parham, MA Chasen, AB Cutting, PJ Pizarro, JM AF Seery, Jason M. Valosen, John M. Phillips, John H., Jr. Slade, Dirk L. Seery, Andrea B. Parham, Mary A. Chasen, Arthur B. Cutting, Paul J. Pizarro, Jose M. TI Effects of Metal Fragments on Nerve Healing in Extremity Injuries Using a Rat Peroneal Nerve Model SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Article; Proceedings Paper CT Conference of the American-College-of-Surgeons-Committee on Trauma Residents Trauma Papers Competition CY 2008 CL Washington, DC SP Amer Coll Surg Comm ID OPERATION IRAQI FREEDOM; FUNCTIONAL-EVALUATION; NEUROTROPHIC FACTOR; ENDURING-FREEDOM; SURGICAL-TEAM; UNITED-STATES; CASUALTIES; SYSTEM; REPAIR; ARMY AB BACKGROUND: Oil the modern battlefield, the majority of injuries Currently seen are to the extremities, often involving a large number of metallic fragments. Although they are typically left ill place, the effects of these retained metal fragments oil nerve healing have not been studied. STUDY DESIGN: In a rat model, the right peroneal nerve was surgically sectioned and reanastomosed (control group). In the study group, metal fragments from an artillery casing were placed around the reanastomosed peroneal nerve. Functional recovery in both groups was evaluated over a 4-week period by measuring maximum ankle dorsiflexion captured on video as the animals walked through a tunnel. Morphologic analyses included distal and proximal axon counts, measurement of nerve fiber and axon diameter ratios, and myelin thickness. RESULTS: A significant decrease (p < 0.05) in return toward baseline for the rats' ankle angle in the nerves exposed to metal fragments was noted at weeks 2 through 4. Distal axon Counts were significantly less (p < 0.05) in the metal fragment (,roup for weeks 1 through 4. Proximal axon counts were increased in both groups, with a greater (p < 0.05) increase in the metal fragment group. CONCLUSIONS: Functional recovery after rat peroneal nerve transection and repair is decreased when metal fragments are placed in and around the injury site. Select histologic indicators of nerve regneration showed decreased healing when exposed to metal fragments. Further studies of functional recovery in patients sustaining penetrating injuries from bullets or explosive devices are indicated. (J Am Coll Surg 2009;209:278-283. (C) 2009 by the American College Of Surgeons) C1 [Seery, Jason M.; Chasen, Arthur B.] Eisenhower Army Med Ctr, Dept Gen Surg, Ft Gordon, GA 30905 USA. [Valosen, John M.; Phillips, John H., Jr.; Slade, Dirk L.; Chasen, Arthur B.; Cutting, Paul J.] Eisenhower Army Med Ctr, Dept Orthoped Surg, Ft Gordon, GA 30905 USA. [Seery, Andrea B.] Eisenhower Army Med Ctr, Dept Pharm, Ft Gordon, GA 30905 USA. [Parham, Mary A.; Pizarro, Jose M.] Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA 30905 USA. RP Seery, JM (reprint author), Eisenhower Army Med Ctr, Dept Gen Surg, 300 Hosp Rd, Ft Gordon, GA 30905 USA. NR 31 TC 2 Z9 3 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD AUG PY 2009 VL 209 IS 2 BP 278 EP 283 DI 10.1016/j.jamcollsurg.2009.04.008 PG 6 WC Surgery SC Surgery GA 480PC UT WOS:000268747300016 PM 19632606 ER PT J AU Liu, KF VanLandingham, MR Ovaert, TC AF Liu, Kaifeng VanLandingham, Mark R. Ovaert, Timothy C. TI Mechanical characterization of soft viscoelastic gels via indentation and optimization-based inverse finite element analysis SO JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS LA English DT Article ID ARTIFICIAL ARTICULAR-CARTILAGE; ELASTIC-MODULUS; DRUG-DELIVERY; POISSON RATIO; NANOINDENTATION; HYDROGELS; TISSUES; COMPRESSION; COMPOSITE; MODELS AB Polymer gels are widely accepted as candidate materials for tissue engineering, drug delivery, and orthopedic load-bearing applications. In addition, their mechanical and physical properties can be tailored to meet a wide range of design requirements. For soft gels whose elastic modulus is in the kPa range, mechanical characterization by bulk mechanical testing methods presents challenges, for example, in sample preparation, fixture design, gripping, and/or load measurement accuracy. Nanoindentation, however, has advantages when characterizing the mechanical properties of soft materials. This study was aimed at investigating the application of an inverse finite element analysis technique to identify material parameters of polymer gels via nanoindentation creep testing, optimization, and finite element simulation. Nanoindentation experiments were conducted using a rigid circular flat punch, and then simulated using the commercial software ABAQUS (TM). The optimization (error minimization) procedure was integrated in the parameter determination process using a Matlab (TM) shell program, which makes this approach readily adaptable to other test geometries and material models. The finite element results compare well with a derived analytical viscoelastic solution for a rigid circular flat punch on a Kelvin-Voigt half-space. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Liu, Kaifeng; Ovaert, Timothy C.] Univ Notre Dame, Dept Aerosp & Mech Engn, Notre Dame, IN 46556 USA. [VanLandingham, Mark R.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Ovaert, TC (reprint author), Univ Notre Dame, Dept Aerosp & Mech Engn, 146 Multidis Res Bldg, Notre Dame, IN 46556 USA. EM tovaert@nd.edu NR 32 TC 35 Z9 38 U1 3 U2 27 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1751-6161 J9 J MECH BEHAV BIOMED JI J. Mech. Behav. Biomed. Mater. PD AUG PY 2009 VL 2 IS 4 BP 355 EP 363 DI 10.1016/j.jmbbm.2008.12.001 PG 9 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA 456HB UT WOS:000266833700007 PM 19627842 ER PT J AU Chung, KK Wolf, SE Cancio, LC Alvarado, R Jones, JA McCorcle, J King, BT Barillo, DJ Renz, EM Blackbourne, LH AF Chung, Kevin K. Wolf, Steven E. Cancio, Leopoldo C. Alvarado, Ricardo Jones, John A. McCorcle, Jeffery King, Booker T. Barillo, David J. Renz, Evan M. Blackbourne, Lorne H. TI Resuscitation of Severely Burned Military Casualties: Fluid Begets More Fluid SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Burns; Resuscitation; Fluids; Complications; Military; Casualties; Parkland; Modified; Brooke; Formula ID PARKLAND FORMULA; COMPLICATIONS; OUTCOMES; PATIENT AB Background: In November 2005, institution of a military-wide burn resuscitation guideline requested the documentation of the initial 24-hour resuscitation of severely burned military casualties on a burn flow sheet to provide continuity of care. The guidelines instruct the providers to calculate predicted 24-hour fluid requirements and initial fluid rate based on the American Burn Association Consensus recommendation of 2 (modified Brooke) mL . kg(-1) . % total body surface area (TBSA)(-1) to 4 (Parkland) mL . kg(-1) . %TBSA(-1) burn. The objective of this study was to evaluate the relationship between the estimated fluid volumes calculated, either by the Modified Brooke or the Parkland formulas, and actual volumes received. Methods: From November 2005 to December 2008, 105 patients were globally evacuated with >20% TBSA burns, of whom 73 had burn flow sheets initiated. Of these, 58 had completed burn flow sheets. Total fluids administered in the first 24-hour period for each patient were recorded. Chart reviews were performed to extract demographic and clinical outcomes data. Results: Of the 58, the modified Brooke formula was used in 31 patients (modified Brooke group) to estimate 24-hour fluid requirements and the Parkland formula was used in 21 (Parkland group). In six, 3 mL . kg(-1) %TBSA(-1) was used and were excluded from analysis. No significant difference was detected between the two groups for age, %TBSA burned, inhalation injury, or Injury Severity Score. Actual 24-hour resuscitation in the modified Brooke group was significantly lower than in the Parkland group (16.9 L +/- 6.0 L vs. 25.0 L +/- 11.2 L, p = 0.003). A greater percentage of patients exceeded the Ivy index (250 mL/kg) in the Parkland group compared with the modified Brooke group (57% vs. 29%, p = 0.026). On average, those who had 24-hour fluid needs estimated by the modified Brooke formula received a 3.8 mL . kg(-1) . %TBSA(-1) 1.2 mL . kg(-1) %TBSA(-1) resuscitation, whereas the Parkland group received a 5.9 mL . kg(-1) . %TBSA(-1) +/- 1.1 mL . kg(-1) . %TBSA(-1) resuscitation (p < 0.0001). No differences in measured outcomes were detected between the two groups. On multivariate logistic regression, exceeding the Ivy index was an independent predictor of death (area under the curve [AUC], 0.807; Cl, 0.66-0.95). Conclusion: fit severely burned military casualties undergoing initial burn resuscitation, the modified Brooke formula resulted in significantly less 24-hour volumes without resulting in higher morbidity or mortality. C1 [Chung, Kevin K.; Wolf, Steven E.; Cancio, Leopoldo C.; Jones, John A.; McCorcle, Jeffery; King, Booker T.; Barillo, David J.; Renz, Evan M.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Wolf, Steven E.; Alvarado, Ricardo] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Chung, KK (reprint author), 3400 Rawley E Chambers Ave, San Antonio, TX 78234 USA. EM kevin.chung@us.army.mil OI Wolf, Steven/0000-0003-2972-3440 NR 20 TC 37 Z9 37 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD AUG PY 2009 VL 67 IS 2 BP 231 EP 237 DI 10.1097/TA.0b013e3181ac68cf PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 482OL UT WOS:000268898500003 PM 19667873 ER PT J AU Park, MS Martini, WZ Dubick, MA Salinas, J Butenas, S Kheirabadi, BS Pusateri, AE Vos, JA Guymon, CH Wolf, SE Mann, KG Holcomb, JB AF Park, Myung S. Martini, Wenjun Z. Dubick, Michael A. Salinas, Jose Butenas, Saulius Kheirabadi, Bijan S. Pusateri, Anthony E. Vos, Jeffrey A. Guymon, Charles H. Wolf, Steven E. Mann, Kenneth G. Holcomb, John B. TI Thromboelastography as a Better Indicator of Hypercoagulable State After Injury Than Prothrombin Time or Activated Partial Thromboplastin Time SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 21st Annual Meeting of the Eastern-Association-for-the-Surgery-of-Trauma CY JAN 15-19, 2008 CL Jacksonville, FL SP Eastern Assoc Surg Trauma DE Deep vein thrombosis; Pulmonary embolism; Thromboelastograph ID MOLECULAR-WEIGHT HEPARIN; FACTOR PATHWAY INHIBITOR; DEEP-VEIN THROMBOSIS; TISSUE-FACTOR; FACTOR-XI; HYPOTHERMIC COAGULOPATHY; VENOUS THROMBOEMBOLISM; FIBRINOLYTIC-ACTIVITY; PROCOAGULANT ACTIVITY; BLOOD-COAGULATION AB Objectives: To investigate the hemostatic status of critically ill, nonbleeding trauma patients. We hypothesized that a hypercoagulable state exists in patients early after severe injury and that the pattern of clotting and fibrinolysis are similar between burned and nonburn trauma patients. Materials: Patients admitted to the Surgical or burn intensive care unit within 24 hours after injury were enrolled. Blood samples were drawn on days 0 through 7. Laboratory tests included prothrombin time (PT). activated partial thromboplastin time (aPTT), levels of activated factor XI, D-dimer, protein C percent activity, antithrombin III percent activity, and thromboelastography (TEG). Results: Study subjects were enrolled front April 1, 2004, to May 3 1, 2005, and included nonburn trauma patients (n = 33), burned patients (n = 25) and healthy (control) subjects (n = 20). Despite aggressive thromboprophylaxis, three subjects (12 burned and I nonburn trauma patients [6%]) had pulmonary embolism during hospitalization. Compared with controls, all patients had prolonged PT and aPTT (p < 0.05). The rate of clot formation (a angle) and maximal clot strength were higher for patients compared with those of controls (p < 0.05), indicating a hypercoagulable state. Injured patients also had lower protein C and antithrombin III percent activities and higher fibrinogen levels (p < 0.05 for all). Activated factor XI was elevated in 38% of patients (control subjects had undetectable levels). Discussion: Thromboelastography analysis of whole blood showed that patients were in a hypercoagulable state; this was not detected by plasma PT or aPTT. The high incidence of pulmonary embolism indicated that our Current prophylaxis regimen could be improved. C1 [Park, Myung S.; Martini, Wenjun Z.; Dubick, Michael A.; Salinas, Jose; Kheirabadi, Bijan S.; Pusateri, Anthony E.; Guymon, Charles H.; Wolf, Steven E.; Holcomb, John B.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Butenas, Saulius; Mann, Kenneth G.] Univ Vermont, Dept Biochem, Burlington, VT 05405 USA. [Vos, Jeffrey A.] W Virginia Univ, Dept Pathol, Morgantown, WV 26506 USA. RP Park, MS (reprint author), Mayo Clin, Div Trauma Crit Care & Gen Surg, 200 1st St SW, Rochester, MN 55905 USA. EM park.myung@mayo.edu OI Wolf, Steven/0000-0003-2972-3440 FU NHLBI NIH HHS [P01 HL046703-18, P01 HL046703-16A1, P01 HL046703-17] NR 63 TC 147 Z9 153 U1 0 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD AUG PY 2009 VL 67 IS 2 BP 266 EP 275 DI 10.1097/TA.0b013e3181ae6f1c PG 10 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 482OL UT WOS:000268898500011 PM 19667878 ER PT J AU Jones, OY Lacson, A Zeng, X Jones, JM Katti, K Cahill, RA Ahmed, AA AF Jones, O. Y. Lacson, A. Zeng, X. Jones, J. M. Katti, K. Cahill, R. A. Ahmed, A. A. TI Long-term follow-up after non-myeloablative transplant of bone and marrow in BXSB mice SO LUPUS LA English DT Article DE mesenchymal stromal cells; rodent; stem cell; systemic lupus erythematosus; transplantation ID MESENCHYMAL STEM-CELLS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; TOTAL LYMPHOID IRRADIATION; AUTOIMMUNE-DISEASE; STROMAL CELLS; DENDRITIC CELLS; MURINE LUPUS; PRONE MICE; T-CELLS; IMMUNE-RESPONSES AB We present long-term outcomes of BXSB mice after non-myeloablative bone marrow transplants using major histocompatability complex (MHC)-matched cells. Groups differed in sources of donor lymphocytes or mesenchymal stromal cells (MSC). Unfractionated marrow cells from green fluorescent protein (GFP) transgenic (Tg) mice (BMT group) or from RAG1-/- B6 mice (RAG group) were injected intravenously (i.v.) into irradiated (550 cGy) hosts. As a source of mesenchymal cells, bone chips from GFP-Tg were injected intraperitoneally alone (MSC group) or along with i.v. bone marrow cells (BMT + MSC group). Controls were untreated mice (UnTx) or mice exposed to radiation only (Rad Cont). At 62 weeks post-transplant, surviving mice were harvested for histopathology, flow cytometry and real time polymerase chain reaction (RT-PCR). The mice from BMT + MSC group had the best outcomes for survival rates (71.4% vs. 43.8%), renal scores (2.9% vs. 28.8% glomerular sclerosis) and percent splenic monocytes (4.2 vs. 11.3%) compared with mice from Rad Cont. Improvement in RAG and BMT groups was less prominent but were comparable with one another. Although MSC alone were not sufficient to control the renal pathology, it limited the expansion of CD4(-)CD8(-) T cell populations without a change in Foxp3 expression. The results suggest the importance of the innate immune system in disease pathogenesis and a role for MSC in immunomodulation. Lupus (2009) 18, 813-821. C1 [Jones, O. Y.] Walter Reed Army Med Ctr, Sect Pediat Rheumatol, Dept Pediat, Washington, DC 20307 USA. [Lacson, A.] Univ Alberta Hosp, Dept Lab Med & Pathol, Mackenzie Hlth Sci Ctr, Edmonton, AB T6G 2R7, Canada. [Zeng, X.] SABiosci Corp, R&D, Frederick, MD USA. [Jones, J. M.] Immunol Consultant, Potomac, MD USA. [Katti, K.] George Washington Univ, Sch Med, Washington, DC USA. [Cahill, R. A.] Cardinal Glennon Hosp, St Louis, MO USA. [Ahmed, A. A.] Childrens Mercy Hosp & Clin, Dept Pathol & Lab Med, Kansas City, MO USA. RP Jones, OY (reprint author), Walter Reed Army Med Ctr, Sect Pediat Rheumatol, Dept Pediat, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM olcay.jones@gmail.com FU Eleanor Naylor Dana Charitable Trust; Children's Research Institute, Washington, DC FX This work was supported by the Eleanor Naylor Dana Charitable Trust and Children's Research Institute, Washington, DC. We extend our sincere thanks to Dr. Teresa Hawley at George Washington University and the staff working at pathology laboratories and animal facilities at All Children's Hospital, St. Petersburg, FL and Children's National Medical Center, Washington, DC for their invaluable help. The authors have no financial conflict of interest. NR 56 TC 0 Z9 0 U1 0 U2 2 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0961-2033 J9 LUPUS JI Lupus PD AUG PY 2009 VL 18 IS 9 BP 813 EP 821 DI 10.1177/0961203309104391 PG 9 WC Rheumatology SC Rheumatology GA 466GR UT WOS:000267649900007 PM 19578106 ER PT J AU Hasan, AU Suguri, S Sattabongkot, J Fujimoto, C Amakawa, M Harada, M Ohmae, H AF Hasan, Arif U. Suguri, Setsuo Sattabongkot, Jetsumon Fujimoto, Chigusa Amakawa, Masao Harada, Masakazu Ohmae, Hiroshi TI Implementation of a novel PCR based method for detecting malaria parasites from naturally infected mosquitoes in Papua New Guinea SO MALARIA JOURNAL LA English DT Article ID POLYMERASE-CHAIN-REACTION; ANOPHELES-PUNCTULATUS GROUP; PLASMODIUM-FALCIPARUM; SOLOMON-ISLANDS; CYTOCHROME-B; POPULATION-STRUCTURE; RFLP ANALYSIS; GROUP DIPTERA; CULICIDAE; SPOROZOITES AB Background: Detection of Plasmodium species in mosquitoes is important for designing vector control studies. However, most of the PCR-based detection methods show some potential limitations. The objective of this study was to introduce an effective PCR-based method for detecting Plasmodium vivax and Plasmodium falciparum from the field-caught mosquitoes of Papua New Guinea. Methods: A method has been developed to concurrently detect mitochondrial cytochrome b (Cyt b) of four human Plasmodium species using PCR (Cytb-PCR). To particularly discriminate P. falciparum from P. vivax, Plasmodium ovale and Plasmodium malariae, a polymerase chain reaction-repeated fragment length polymorphism (PCR-RFLP) has further been developed to use with this method. However, due to limited samples number of P. ovale and P. malariae; this study was mainly confined to P. vivax and P. falciparum. The efficiency of Cytb-PCR was evaluated by comparing it with two 'gold standards' enzyme linked immunosorbent assay specific for circumsporozoite protein (CS-ELISA) using artificially infected mosquitoes; and nested PCR specific for small subunit ribosomal RNA (SSUrRNA) using field caught mosquitoes collected from three areas (Kaboibus, Wingei, and Jawia) of the East Sepic Province of Papua New Guinea. Results: A total of 90 mosquitoes were artificially infected with three strains of Plasmodium: P. vivax-210 (n = 30), P. vivax-247 (n = 30) and P. falciparum (n = 30). These infected mosquitoes along with another 32 unfed mosquitoes were first checked for the presence of Plasmodium infection by CS-ELISA, and later the same samples were compared with the Cytb-PCR. CS-ELISA for P. vivax-210, P. vivax-247 and P. falciparum detected positive infection in 30, 19 and 18 mosquitoes respectively; whereas Cytb-PCR detected 27, 16 and 16 infections, respectively. The comparison revealed a close agreement between the two assays (kappa = 0.862, 0.842 and 0.894, respectively for Pv-210, Pv-247 and P. falciparum groups). It was found that the eight CS-ELISA-positive mosquitoes detected negative by Cytb-PCR were false-positive results. The lowest detection limit of this Cytb-PCR was 10 sporozoites. A highly concordance result was also found between nested PCR and Cytb-PCR using 107 field caught mosquitoes, and both tests concordantly detected P. falciparum in an Anopheles punctulatus mosquito collected from Kaboibus. Both tests thus suggested an overall sporozoite rate of 0.9% (1/107) in the study areas. Subsequently, PCR-RFLP efficiently discriminated P. falciparum from P. vivax for all of the Cytb-PCR positive samples. Conclusion: A single step PCR based method has been introduced here that is highly sensitive, efficient and reliable for identifying P. vivax and P. falciparum from mosquitoes. The reliability of the technique was confirmed by its ability to detect Plasmodium as efficiently as those of CS-ELISA and nested PCR. Application of the assay offers the opportunity to detect vector species of Papua New Guinea and may contribute for designing further vector control programmes. C1 [Hasan, Arif U.; Suguri, Setsuo; Fujimoto, Chigusa; Harada, Masakazu] Kagawa Univ, Dept Int Med Zool, Fac Med, Kita Ku, Kagawa 7610793, Japan. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, US Army Med Component, Dept Entomol, Bangkok 10400, Thailand. [Fujimoto, Chigusa; Amakawa, Masao] Kagawa Prefectural Coll Hlth Sci, Fac Hlth Sci, Dept Med Technol, Kagawa 7610123, Japan. [Ohmae, Hiroshi] Natl Inst Infect Dis, Dept Parasitol, Shinjuku Ku, Tokyo 1623640, Japan. RP Hasan, AU (reprint author), Kagawa Univ, Dept Int Med Zool, Fac Med, Kita Ku, 1750-1 Ikenobe, Kagawa 7610793, Japan. EM ahasan@med.kagawa-u.ac.jp; suguri@med.kagawa-u.ac.jp; JetsumonP@afrims.org; fujimoto@chs.pref.kagawa.jp; amakawa@chs.pref.kagawa.jp; mharada@med.kagawa-u.ac.jp; h-ohmae@nih.go.jp FU Ministry of Education, Culture, Sports, Science and Technology [174060080]; Japan International Cooperation Agency Partnership Programme FX This work was supported in part by a Grant-in Aid for Scientific Research (B) [ KAKENHI (174060080 to SS)] from the Ministry of Education, Culture, Sports, Science and Technology, a Grant-in Aid from the Ministry of Health, Labour and Welfare (H17-Shinkou-ippan-019 to HO, H-20-Shinkou-ippan-015 to SS and HO) and by the Integrated Cooperative Research for Malaria Control Project founded by the Government of Japan under the Japan International Cooperation Agency Partnership Programme. NR 53 TC 15 Z9 15 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA CURRENT SCIENCE GROUP, MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD AUG 1 PY 2009 VL 8 AR 182 DI 10.1186/1475-2875-8-182 PG 11 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 486CE UT WOS:000269172300001 PM 19646275 ER PT J AU Boyles, RE Ritland, BM Miracle, BM Barclay, DM Faul, MS Moore, JH Koppenhaver, SL Wainner, RS AF Boyles, Robert E. Ritland, Bradley M. Miracle, Brian M. Barclay, Daniel M. Faul, Mary S. Moore, Josef H. Koppenhaver, Shane L. Wainner, Robert S. TI The short-term effects of thoracic spine thrust manipulation on patients with shoulder impingement syndrome SO MANUAL THERAPY LA English DT Article DE Shoulder impingement; Shoulder pain; Thoracic spine thrust manipulation; Manual physical therapy ID LOW-BACK-PAIN; MANUAL PHYSICAL-THERAPY; RANDOMIZED CONTROLLED-TRIAL; CLINICAL-PREDICTION RULE; INTERNAL IMPINGEMENT; ATHLETIC SHOULDER; DISABILITY INDEX; GENERAL-PRACTICE; EXERCISE; RESPONSIVENESS AB The study was ail exploratory, one group pretest/post-test study, with the objective of investigating the short-term effects of thoracic spine thrust manipulations (TSTMs) on patients with shoulder impingement syndrome (SIS). There is evidence that manual physical therapy that includes TSTM and non-thrust manipulation and exercise is effective for the treatment of patients with SIS. However, the relative contributions of specific manual therapy interventions are not known. To date, no published studies address the short-term effects of TSTM in the treatment of SIS. Fifty-six patients (40 males, 16 females; mean age 31.2 +/- 8.9) with SIS underwent a standardized shoulder examination, immediately followed by TSTM techniques. Outcomes measured were the Numeric Pain and Rating Scale (NPRS) and the Shoulder Pain and Disability Index (SPADI), all collected at baseline and at a 48-h follow-up period. Additionally, the Global Rating of Change Scale (GRCS) was collected at 48-h follow-up to measure patient perceived change. At 48-h follow-up, the NPRS change scores for Neer impingement sign, Hawkins impingement sign, resisted empty can, resisted external rotation, resisted internal rotation, and active abduction were all statistically significant (p < 0.01). The reduction in the SPADI score was also statistically significant (p < 0.001) and the mean GRCS score = 1.4 +/- 2.5. In conclusion, TSTM provided a statistically significant decrease in self reported pain measures and disability in patients with SIS at 48-h follow-up. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Boyles, Robert E.] Univ Puget Sound, Sch Phys Therapy, Tacoma, WA 98416 USA. [Ritland, Bradley M.; Miracle, Brian M.; Barclay, Daniel M.; Faul, Mary S.; Moore, Josef H.; Koppenhaver, Shane L.] Baylor Univ, USA, Doctoral Program Phys Therapy, Houston, TX 77030 USA. [Wainner, Robert S.] Texas State Univ, Phys Therapy Dept, San Marcos, TX USA. RP Boyles, RE (reprint author), Univ Puget Sound, Sch Phys Therapy, 1500N Warner St, Tacoma, WA 98416 USA. EM bboyles@ups.edu NR 47 TC 36 Z9 36 U1 2 U2 11 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1356-689X J9 MANUAL THER JI Man. Ther. PD AUG PY 2009 VL 14 IS 4 BP 375 EP 380 DI 10.1016/j.math.2008.05.005 PG 6 WC Rehabilitation SC Rehabilitation GA 470GI UT WOS:000267962800005 PM 18703377 ER PT J AU Stephenson, LD AF Stephenson, L. D. TI More on crystal structure of metals SO MATERIALS PERFORMANCE LA English DT Letter C1 USA, Construct Engn Res Lab, ERDC, Corps Engineers, Champaign, IL 61824 USA. RP Stephenson, LD (reprint author), USA, Construct Engn Res Lab, ERDC, Corps Engineers, Champaign, IL 61824 USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU NATL ASSOC CORROSION ENG PI HOUSTON PA 1440 SOUTH CREEK DRIVE, HOUSTON, TX 77084-4906 USA SN 0094-1492 J9 MATER PERFORMANCE JI Mater. Perform. PD AUG PY 2009 VL 48 IS 8 BP 14 EP 14 PG 1 WC Materials Science, Characterization & Testing SC Materials Science GA 477XK UT WOS:000268552100002 ER PT J AU Hock, VF AF Hock, Vincent F. TI Winning the War on Corrosion SO MATERIALS PERFORMANCE LA English DT Editorial Material C1 USA, Construct Engn Res Lab, Engineer Res & Dev Ctr, Corps Engineers, Champaign, IL 61824 USA. RP Hock, VF (reprint author), USA, Construct Engn Res Lab, Engineer Res & Dev Ctr, Corps Engineers, Champaign, IL 61824 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATL ASSOC CORROSION ENG PI HOUSTON PA 1440 SOUTH CREEK DRIVE, HOUSTON, TX 77084-4906 USA SN 0094-1492 J9 MATER PERFORMANCE JI Mater. Perform. PD AUG PY 2009 VL 48 IS 8 BP 18 EP 19 PG 2 WC Materials Science, Characterization & Testing SC Materials Science GA 477XK UT WOS:000268552100007 ER PT J AU Rogers, JR AF Rogers, John R. TI Low-cost teleoperable robotic arm SO MECHATRONICS LA English DT Article DE Teleoperation; Master-slave; Manipulator; Low-cost ID DELAY AB A low-cost robotic arm and controller system is presented. The controller is a desktop model of the robotic arm with the same degrees of freedom whose joints are equipped with sensors. Manipulating the controller by hand causes the robotic arm to mimic the movement in master-slave fashion. This is accomplished simply and at low-cost by taking advantage of widely available hobby radio control components. The system uses the trainer ("Buddy Box") function available on common radio control transmitters as a simple interface between microcontroller and transmitter. The microcontroller produces a time-division multiplexed signal comprising three channels in proportional pulse modulated (PPM) format. The arm design could be used for various light-duty applications and this paper describes a version fitted with a video camera. The arm prototype is designed for an under-vehicle inspection robot. In this application, the video camera mounted on the robotic arm allows inspection of difficult-to-view locations under vehicles. The master-slave operator interface provides an easy-to-learn method for robotic arm manipulation. Published by Elsevier Ltd. C1 US Mil Acad, Dept Civil Engn & Mech, West Point, NY 10996 USA. RP Rogers, JR (reprint author), US Mil Acad, Dept Civil Engn & Mech, West Point, NY 10996 USA. EM john.rogers@usma.edu FU United States Army Tank Automotive Research, Development and Engineering Center (TARDEC) FX The author expresses thanks to the United States Army Tank Automotive Research, Development and Engineering Center (TARDEC) for their support of this project. Thanks also to Carl Fossa and Isaac Rogers for sharing their knowledge, providing suggestions, and helping with experiments on this project. NR 11 TC 4 Z9 4 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0957-4158 J9 MECHATRONICS JI Mechatronics PD AUG PY 2009 VL 19 IS 5 BP 774 EP 779 DI 10.1016/j.mechatronics.2009.03.004 PG 6 WC Automation & Control Systems; Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic; Engineering, Mechanical SC Automation & Control Systems; Computer Science; Engineering GA 466TP UT WOS:000267686000020 ER PT J AU Nace, MC Dunlow, S Armstrong, AY AF Nace, M. Catherine Dunlow, Susan Armstrong, Alicia Y. TI Professionalism in Medicine: We Should Set the Standard SO MILITARY MEDICINE LA English DT Article ID DEANS LETTERS; DISCIPLINARY ACTION; SCHOOLS; PHYSICIAN; RESIDENTS; AWARENESS; BEHAVIOR AB As military physicians we have a unique set of professional values that may differ from our civilian counterparts because we have both our professional responsibilities to our patients as well as our professional values as military officers. Our core military values provide a solid foundation to set the standard for professionalism in medicine. As educators for medical students, residents, and fellows we have an obligation to not only teach them the art of medicine but to mentor them as professional military officers. The objectives of this article are threefold: first to define professionalism, second to identify measurement tools, and finally to offer suggestions for documentation and remediation when problems of professionalism are identified among residents and fellows. C1 [Nace, M. Catherine; Dunlow, Susan] Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Washington, DC 20307 USA. [Armstrong, Alicia Y.] Natl Inst Child Hlth & Human Dev, Program Reprod & Adult Endocrinol, Bethesda, MD USA. RP Nace, MC (reprint author), Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Washington, DC 20307 USA. NR 17 TC 2 Z9 2 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 2009 VL 174 IS 8 BP 807 EP 810 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 601LG UT WOS:000278060300009 PM 19743734 ER PT J AU Hsu, JR Beltran, MJ AF Hsu, Joseph R. Beltran, Michael J. CA Skeletal Trauma Res Consortium STR TI Shortening and Angulation for Soft-Tissue Reconstruction of Extremity Wounds in a Combat Support Hospital SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT 48th Annual Meeting of the Society-of-Military-Orthopaedic-Surgeons CY DEC 11-16, 2006 CL Honolulu, HI SP Soc Mil Orthopaed Surg ID CIRCULAR EXTERNAL FIXATOR; OPEN TIBIAL FRACTURES; ILIZAROV-TECHNIQUE; INFECTED NONUNION; LIMB SALVAGE; LEG TRAUMA; BONE; DEFECTS; COMPLICATIONS; MANAGEMENT AB Background: Bone and soft-tissue loss are common extremity injuries sustained in current military conflicts. Selected host national patients had their definitive orthopedic care performed at our combat support hospital. Soft-tissue reconstruction can be a challenging task in this environment. There are several situations in which free or rotational flap coverage is not possible, including the presence of a single vessel limb, local muscle damage, and/or nonavailability of an experienced flap surgeon. The technique of shortening and angulation for extremity soft-tissue reconstruction is described using tools available in a theater of operations. Methods: We treated 6 limbs in 5 patients with the technique of shortening and/or angulation to obtain soft-tissue coverage for extremity war wounds at our combat support hospital. Bony stabilization was accomplished using the standard Hoffman II external fixator (Stryker Orthopedics, Mahwah, NJ). The extremities treated included: 2 humerus fractures, 3 tibia fractures, and 1 ankle fracture. Two of the patients required vascular reconstruction. Patients were followed for as long as possible given individual circumstances. Results: One patient in the series died of multiple organ system failure because of intra-abdominal injuries. Average follow-up on the remaining patients was 7.03 weeks (1 to 14 weeks). In the patient with 1-week follow-up, the skin graft had 100% take. All other wounds were healed at the latest follow-up without signs of infection. Conclusion: Shortening and/or angulation of extremities with bone and soft-tissue loss is an effective means of obtaining soft-tissue coverage in a theater of operations. C1 [Hsu, Joseph R.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Beltran, Michael J.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Hsu, JR (reprint author), USA, Inst Surg Res, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 49 TC 6 Z9 6 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 2009 VL 174 IS 8 BP 838 EP 842 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 601LG UT WOS:000278060300015 PM 19743740 ER PT J AU Skiba, V Barner, KC AF Skiba, Virginia Barner, Kristen C. TI Central Nervous System Manifestations of Q Fever Responsive to Steroids SO MILITARY MEDICINE LA English DT Article ID ENCEPHALITIS AB We report the clinical and radiological central nervous system manifestations of a 27-year-old man with Q fever who subsequently developed acute disseminated encephalomyelitis and showed a significant response to steroids. The patient presented with headache and fever and quickly progressed to develop acute respiratory failure and hepatitis. A prompt evaluation revealed positive serology for Q fever and doxycycline was initiated. Approximately I week into his illness he was noted to be profoundly weak. Neuroimaging with magnetic resonance imaging (MRI) revealed diffuse white matter T2/FLAIR hyperintensities, with evidence of restricted diffusion. He was given high-dose steroids for a presumed diagnosis of acute disseminated encephalomyelitis (ADEM) and within days he had both clinical and MRI improvement. In addition to well-described meningitis and encephalitis. Q fever may also he associated with diffuse CNS lesions that may be demyelinating inflammatory in pathophysiology, and therefore responsive to high-dose steroids. C1 [Skiba, Virginia; Barner, Kristen C.] Walter Reed Army Med Ctr, Dept Neurol, Washington, DC 20307 USA. RP Skiba, V (reprint author), Walter Reed Army Med Ctr, Dept Neurol, 6900 Georgia Ave, Washington, DC 20307 USA. NR 8 TC 2 Z9 2 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 2009 VL 174 IS 8 BP 857 EP 859 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 601LG UT WOS:000278060300018 PM 19743743 ER PT J AU Brockmeyer, J Simon, T Seery, J Johnson, E Armstrong, P AF Brockmeyer, Joel Simon, Todd Seery, Jason Johnson, Eric Armstrong, Peter TI Cerebral Air Embolism Following Removal of Central Venous Catheter SO MILITARY MEDICINE LA English DT Article ID GAS EMBOLISM; CARE AB Cerebral air embolism occurs very seldom as a complication of central venous catheterization. We report a 57-year-old female with cerebral air embolism secondary to removal of a central venous catheter (CVC). The patient was treated with supportive measures and recovered well with minimal long-term injury. The prevention of air embolism related to central venous catheterization is discussed. C1 [Brockmeyer, Joel; Simon, Todd; Seery, Jason; Johnson, Eric; Armstrong, Peter] Eisenhower Army Med Ctr, Dept Surg, Ft Gordon, GA 30905 USA. RP Brockmeyer, J (reprint author), Eisenhower Army Med Ctr, Dept Surg, 300 Hosp Rd, Ft Gordon, GA 30905 USA. NR 17 TC 6 Z9 8 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 2009 VL 174 IS 8 BP 878 EP 881 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 601LG UT WOS:000278060300023 PM 19743748 ER PT J AU Moore, DF Jerusalem, A Nyein, M Noels, L Jaffee, MS Radovitzky, RA AF Moore, David F. Jerusalem, Antoine Nyein, Michelle Noels, Ludovic Jaffee, Michael S. Radovitzky, Raul A. TI Computational biology - Modeling of primary blast effects on the central nervous system SO NEUROIMAGE LA English DT Article ID TRAUMATIC BRAIN-INJURY; VIRTUAL TEST FACILITY; MECHANICAL-PROPERTIES; CONSTITUTIVE MODEL; DYNAMIC-RESPONSE; HUMAN HEAD; IMPACT; TISSUE; OVERPRESSURE; CONCUSSION AB Objectives: Recent military conflicts in Iraq and Afghanistan have highlighted the wartime effect of traumatic brain injury (TBI). The reason for the prominence of TBI in these particular conflicts as opposed to others is unclear but may result from the increased survivability of blast due to improvements in body armor. In the military context blunt, ballistic and blast effects may all contribute to CNS injury, however blast in Particular, has been suggested as a primary cause of military TBI. While blast effects on some biological tissues, such as the lung, are documented in terms of injury thresholds, this is not the case for the CNS. We hypothesized that using bio-fidelic models, allowing for fluid-solid interaction and basic material properties available in the literature, a blast wave would interact with CNS tissue and cause a possible concussive effect. Methods: The modeling approach employed for this investigation consisted of a computational framework suitable for simulating coupled fluid-solid dynamic interactions. The model included a complex finite element mesh of the head and intra-cranial contents. The effects of threshold and 50% lethal blast lung injury were compared with concussive impact injury using the full head model allowing upper and lower bounds of tissue injury to be applied using pulmonary injury as the reference tissue. Results: The effects of a 50% lethal dose blast lung injury (LD(50)) were Comparable with concussive impact injury using the DVBIC-MIT full head model. Interpretation: CNS blast concussive effects were found to be similar between impact mild TBI and the blast field associated with LD50 lung blast injury sustained without personal protective equipment. With the ubiquitous use of personal protective equipment this suggests that blast concussive effects may more readily ascertained in personnel due to enhanced survivability in the current conflicts. (C) 2009 Published by Elsevier Inc. C1 [Moore, David F.; Jaffee, Michael S.] Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20309 USA. [Jerusalem, Antoine; Nyein, Michelle; Radovitzky, Raul A.] MIT, Dept Aeronaut & Astronaut, Cambridge, MA 02139 USA. [Noels, Ludovic] Univ Liege, Dept Aerosp & Mech Engn, Liege, Belgium. RP Moore, DF (reprint author), Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Bldg 1,Room B207,6900 Georgia Ave NW, Washington, DC 20309 USA. EM david.f.moore@amedd.army.mil RI Radovitzky, Raul/A-5353-2009; OI Radovitzky, Raul/0000-0001-6339-2708; Noels, Ludovic/0000-0002-7224-5539; Jerusalem, Antoine/0000-0001-5026-8038 NR 55 TC 88 Z9 92 U1 1 U2 26 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1053-8119 J9 NEUROIMAGE JI Neuroimage PD AUG PY 2009 VL 47 SU 2 BP T10 EP T20 DI 10.1016/j.neuroimage.2009.02.019 PG 11 WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA 487FX UT WOS:000269257400004 PM 19248833 ER PT J AU Warden, DL French, LM Shupenko, L Fargus, J Riedy, G Erickson, ME Jaffee, MS Moore, DF AF Warden, Deborah L. French, Louis M. Shupenko, Leslie Fargus, Jamie Riedy, Gerard Erickson, Marleigh E. Jaffee, Michael S. Moore, David F. TI Case report of a soldier with primary blast brain injury SO NEUROIMAGE LA English DT Article AB Primary blast injury of the central nervous system is described in a service-member exposed to a large ordinance explosion. Neuroimaging abnormalities are described together with normalization of the fractional anisotrophy on diffusion tensor imaging after follow-up imaging studies. (C) 2009 Elsevier Inc. All rights reserved. C1 [Warden, Deborah L.; French, Louis M.; Shupenko, Leslie; Fargus, Jamie; Jaffee, Michael S.; Moore, David F.] Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20309 USA. [Riedy, Gerard] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20309 USA. [Erickson, Marleigh E.] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. [French, Louis M.] Walter Reed Army Med Ctr, Dept Orthoped & Rehabil, Traumat Brain Injury Serv, Washington, DC 20309 USA. RP Moore, DF (reprint author), Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Bldg 1,Room B207,6900 Georgia Ave NW, Washington, DC 20309 USA. EM david.f.moore@amedd.army.mil NR 6 TC 41 Z9 41 U1 0 U2 5 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1053-8119 J9 NEUROIMAGE JI Neuroimage PD AUG PY 2009 VL 47 BP T152 EP T153 DI 10.1016/j.neuroimage.2009.01.060 PG 2 WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA 487FX UT WOS:000269257400021 PM 19457364 ER PT J AU Ramsay, LB Wright, J Fischer, JR AF Ramsay, Laura B. Wright, Johnnie, Jr. Fischer, John R. TI Sacral Neuromodulation in the Treatment of Vulvar Vestibulitis Syndrome SO OBSTETRICS AND GYNECOLOGY LA English DT Article; Proceedings Paper CT 57th Annual Clinical Meeting of the American-College-of-Obstetricians-and-Gynecologists CY MAY 02-06, 2009 CL Chicago, IL SP Amer Coll Obstet & Gynecol AB BACKGROUND: Vulvar vestibular syndrome is a chronic pain syndrome that typically results in pain and irritation of the vulvar vestibule and has few effective options for treatment. CASE: A 42-year-old woman presented with symptoms consistent with chronic vulvar vestibular syndrome that was refractory to multiple attempted therapies. The patient was offered sacral neuromodulation for treatment. She underwent a standard two-phase surgical implantation with good result at 2 years postimplantation. CONCLUSION: Sacral neuromodulation was shown to be a valid treatment option for this patient and resulted in excellent patient satisfaction at 2-year follow-up. Although the exact mechanism of action is unknown, sacral neuromodulation may be a viable option for the management of chronic pain syndromes of the vulva and vagina. (Obstet Gynecol 2009;114:487-9) C1 [Wright, Johnnie, Jr.] Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Female Pelv Med & Reconstruct Surg, Washington, DC 20307 USA. RP Wright, J (reprint author), Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Female Pelv Med & Reconstruct Surg, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM johnnie.wright@us.army.mil NR 8 TC 11 Z9 11 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD AUG PY 2009 VL 114 IS 2 BP 487 EP 489 PG 3 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 476DQ UT WOS:000268418400030 PM 19622972 ER PT J AU Salem, S Halford, C Moyer, S Gundy, M AF Salem, Salem Halford, Carl Moyer, Steve Gundy, Matthew TI Rotational clutter metric SO OPTICAL ENGINEERING LA English DT Article DE clutter; linear discriminant analysis; orthogonal geometric rotations; Bayesian decision theory ID DETECTION PERFORMANCE; DETECTION PROBABILITY; INFRARED IMAGES AB A new approach to linear discriminant analysis (LDA), called orthogonal rotational LDA (ORLDA) is presented. Using ORLDA and properly accounting for target size allowed development of a new clutter metric that is based on the Laplacian pyramid (LP) decomposition of clutter images. The new metric achieves correlation exceeding 98% with expert human labeling of clutter levels in a set of 244 infrared images. Our clutter metric is based on the set of weights for the LP levels that best classify images into clutter levels as manually classified by an expert human observer. LDA is applied as a preprocessing step to classification. LDA suffers from a few limitations in this application. Therefore, we propose a new approach to LDA, called ORLDA, using orthonormal geometric rotations. Each rotation brings the LP feature space closer to the LDA solution while retaining orthogonality in the feature space. To understand the effects of target size on clutter, we applied ORLDA at different target sizes. The outputs are easily related because they are functions of orthogonal rotation angles. Finally, we used Bayesian decision theory to learn class boundaries for clutter levels at different target sizes. (C) 2009 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3204234] C1 [Salem, Salem; Halford, Carl] Univ Memphis, Memphis, TN 38152 USA. [Moyer, Steve] USA, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. [Gundy, Matthew] EOIR Technol, Fredericksburg, VA 22408 USA. RP Salem, S (reprint author), Univ Memphis, 206 Engn Sci Bldg, Memphis, TN 38152 USA. EM ssalem@memphis.edu FU Army's Night Vision and Electronic Sensors Directorate; EOIR Technologies; Army Research Laboratory [W911NF-05-2-0019]; Office of Naval Research [N00014-05-1-0446]; Army Research Office [W911NF-05-1-0307] FX Salem Salem and Carl Halford gratefully acknowledge support of the Army's Night Vision and Electronic Sensors Directorate, EOIR Technologies, the Army Research Laboratory under Grant No. W911NF-05-2-0019, the Office of Naval Research under Grant No. N00014-05-1-0446, and the Army Research Office under Grant No. W911NF-05-1-0307. NR 15 TC 4 Z9 4 U1 0 U2 1 PU SPIE-SOC PHOTOPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD AUG PY 2009 VL 48 IS 8 AR 086401 DI 10.1117/1.3204234 PG 11 WC Optics SC Optics GA 504ED UT WOS:000270596700020 ER PT J AU D'Anci, KE Vibhakar, A Kanter, JH Mahoney, CR Taylor, HA AF D'Anci, Kristen E. Vibhakar, Arjun Kanter, Jordan H. Mahoney, Caroline R. Taylor, Holly A. TI VOLUNTARY DEHYDRATION AND COGNITIVE PERFORMANCE IN TRAINED COLLEGE ATHLETES SO PERCEPTUAL AND MOTOR SKILLS LA English DT Article ID EXERCISE-INDUCED DEHYDRATION; HEAT-STRESS; GLUCOSE ENHANCEMENT; ELDERLY HUMANS; BLOOD-GLUCOSE; CONFECTIONERY SNACK; MENTAL PERFORMANCE; MEMORY ENHANCEMENT; YOUNG-ADULTS; ATTENTION AB Cognitive and mood decrements resulting from mild dehydration and glucose consumption were studied. Men and women (total N = 54; M age = 19.8 yr., SD = 1.2) were recruited from college athletic teams. Euhydration or dehydration was achieved by athletes completing team practices with or without water replacement. Dehydration was associated with higher thirst and negative mood ratings as well as better Digit Span performance. Participants showed better Vigilance Attention with euhydration. Hydration status and athlete's sex interacted with performance on Choice Reaction Time and Vigilance Attention. In a second study, half of the athletes received glucose prior to cognitive testing. Results for negative mood and thirst ratings were similar, but for cognitive performance the results were mixed. Effects of glucose on cognition were independent of dehydration. C1 [D'Anci, Kristen E.; Vibhakar, Arjun; Kanter, Jordan H.; Taylor, Holly A.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. [Mahoney, Caroline R.] US Army Soldier Syst Ctr, Natick Soldier Ctr, Natick, MA USA. RP D'Anci, KE (reprint author), Tufts Univ, Dept Psychol, Psychol Bldg,490 Boston Ave, Medford, MA 02155 USA. FU NIDDK NIH HHS [T32 DK007651] NR 45 TC 24 Z9 27 U1 3 U2 18 PU AMMONS SCIENTIFIC, LTD PI MISSOULA PA PO BOX 9229, MISSOULA, MT 59807-9229 USA SN 0031-5125 J9 PERCEPT MOTOR SKILL JI Percept. Mot. Skills PD AUG PY 2009 VL 109 IS 1 BP 251 EP 269 DI 10.2466/PMS.109.1.251-269 PG 19 WC Psychology, Experimental SC Psychology GA 498EC UT WOS:000270118700023 PM 19831106 ER PT J AU Raisch, DW Straight, TM Holodniy, M AF Raisch, Dennis W. Straight, Timothy M. Holodniy, Mark TI Thrombocytopenia from Combination Treatment with Oseltamivir and Probenecid: Case Report, MedWatch Data Summary, and Review of the Literature SO PHARMACOTHERAPY LA English DT Article DE thrombocytopenia; oseltamivir; probenecid ID ADVERSE DRUG-REACTIONS; AVIAN INFLUENZA; THERAPY AB The possibility of an avian flu pandemic has spurred interest in preventive treatments with antivirals such as oseltamivir. Combining treatment with probenecid to delay excretion may extend limited supplies of oseltamivir. We previously conducted a pharmacokinetic study of oseltamivir plus probenecid among healthy volunteers. In this article, we describe a 68-year-old woman who, during the pharmacokinetic study, developed severe thrombocytopenia 2 weeks after starting oseltamivir plus probenecid. She was receiving no other drug therapy at the time. Her platelet count decreased from 200 to 15 x 10(3)/mm(3), although no clinically evident bleeding abnormalities were noted. The two drugs were discontinued. One week later, without any therapeutic intervention, her platelet count returned to normal. By using the Naranjo adverse drug reaction probability scale to assess the strength of the association between the drugs and the adverse event, a score of 7 was derived for both drugs, indicating that the association was probable. We found no previous literature reports of thrombocytopenia associated with either drug. However, a review of the United States Food and Drug Administration's Adverse Event Reporting System database found 93 cases of thrombocytopenia and/or decreased platelet counts associated with oseltamivir and 24 cases associated with probenecid administration. Signal detection analyses were significant for oseltamivir (p=0.001), but not probenecid. The underlying mechanism of thrombocytopenia with these drugs is unknown. Clinicians should be aware that the use of oseltamivir and probenecid has been reported to be associated with thrombocytopenia. C1 [Raisch, Dennis W.] Univ New Mexico, Coll Pharm, Hlth Sci Ctr, Albuquerque, NM 87131 USA. [Raisch, Dennis W.] Cooperat Studies Prograrn Clin Res Pharm, Dept Vet Affairs, Albuquerque, NM USA. [Straight, Timothy M.] Brooke Army Med Ctr, Dept Clin Invest, San Antonio, TX USA. [Holodniy, Mark] Stanford Univ, Div Infect Dis, Dept Vet Affairs Palo Alto Hlth Care Syst, Stanford, CA 94305 USA. RP Raisch, DW (reprint author), Univ New Mexico, Coll Pharm, Hlth Sci Ctr, 1 Univ New Mexico, Albuquerque, NM 87131 USA. EM draisch@salud.unm.edu FU U.S. Department of Veterans Affairs Cooperative Studies Program; U.S. Department of Veterans Affairs Merit Review; U.S. Army Office of the Surgeon General FX This study was funded by the U.S. Department of Veterans Affairs Cooperative Studies Program. The parent study was supported by a U.S. Department of Veterans Affairs Merit Review grant to Mark Holodniy and additional financial support to Timothy M. Straight from the U.S. Army Office of the Surgeon General. NR 20 TC 8 Z9 8 U1 0 U2 1 PU PHARMACOTHERAPY PUBLICATIONS INC PI BOSTON PA NEW ENGLAND MEDICAL CENTER, 806, 750 WASHINGTON ST, BOSTON, MA 02111 USA SN 0277-0008 J9 PHARMACOTHERAPY JI Pharmacotherapy PD AUG PY 2009 VL 29 IS 8 BP 988 EP 992 PG 5 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 478BW UT WOS:000268563800012 PM 19637952 ER PT J AU Soln, J AF Soln, Josip TI Massive neutrinos, Lorentz invariance dominated standard model and the phenomenological approach to neutrino oscillations SO PHYSICA SCRIPTA LA English DT Article AB For the electroweak interactions, the massive neutrino perturbative kinematical procedure is developed in the massive neutrino Fock space. The perturbation expansion parameter is the ratio of neutrino mass to its energy. This procedure, within the Pontecorvo-Maki-Nakagawa-Sakata (PMNS)-modified electroweak Lagrangian, calculates the cross-sections with the new neutrino energy projection operators in the massive neutrino Fock space, resulting in the dominant Lorentz invariant standard model massless flavor neutrino cross-sections. As a consequence of the kinematical relations between the massive and massless neutrinos, some of the neutrino oscillation cross-sections are Lorentz invariance violating. But all these oscillating cross-sections, some of which violate the flavor conservation, being proportional to the squares of neutrino masses are practically unobservable in the laboratory. However, these neutrino oscillating cross-sections are consistent with the original Pontecorvo neutrino oscillating transition probability expression at short time ( baseline), as presented by Dvornikov. From these comparisons, by mimicking the time dependence of the original Pontecorvo neutrino oscillating transition probability, one can formulate the dimensionless neutrino intensity-probability I, by phenomenologically extrapolating the time t, or, equivalently the baseline distance L away from the collision point for the oscillating differential cross-section. For the incoming neutrino of 10 MeV in energy and neutrino masses from Fritzsch analysis with the neutrino mixing matrix of Harrison, Perkins and Scott, the baseline distances at the first two maxima of the neutrino intensity are L similar or equal to 281 and 9279 km. The intensity I at the first maximum conserves the flavor, while at the second maximum, the intensities violate the flavor, respectively, in the final and initial state. At the end some details are given as to how one should be able to verify experimentally these neutrino oscillations away from the collision point. In the material presented here one reinforces the notion that the massless flavor neutrino can be considered as the superposition of three massive neutrinos. C1 [Soln, Josip] JZS Phys Tech, Army Res Lab Ret, Vienna, VA 22182 USA. EM soln.phystech@cox.net NR 26 TC 0 Z9 0 U1 0 U2 1 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0031-8949 J9 PHYS SCRIPTA JI Phys. Scr. PD AUG PY 2009 VL 80 IS 2 AR 025101 DI 10.1088/0031-8949/80/02/025101 PG 9 WC Physics, Multidisciplinary SC Physics GA 480WI UT WOS:000268767300007 ER PT J AU Ashman, CR Pennington, G AF Ashman, Christopher R. Pennington, Gary TI First-principles study of oxygen adsorption on the nitrogen-passivated 4H-SiC (0001) silicon face SO PHYSICAL REVIEW B LA English DT Article ID SIC/SIO2 INTERFACE; ATOMIC-SCALE; PHOTOELECTRON-SPECTROSCOPY; CONDUCTION-BAND; NITRIC-OXIDE; SURFACES; DENSITY; OXYNITRIDES; OXIDATION; SIO2 AB The effects of oxygen and nitrogen adsorption and interaction on the 4H-SiC (0001) surface are investigated using the density-functional theory coupled with molecular dynamics. Nitrogen coverages from 1/9 to 5/4 monolayer are considered. The adsorption sites for isolated oxygen atoms and molecules are considered as well as the interaction between oxygen and nitrogen on the surface. The primary findings are that adsorbed atomic oxygen and nitrogen repel each other. At sparse coverages (n+m < 1/3, n=monolayers of nitrogen and m=monolayers of oxygen) the oxygen atoms bond to two surface-silicon dangling bonds while the nitrogen atoms consume three. For higher densities of oxygen and nitrogen, pairs of nitrogen atoms may combine to form N-2 dimers with each pair dangling from the top of a surface-silicon atom, thus increasing the number of silicon-surface bond sites available at the given coverage. However the N-2 are only weakly bound with respect to gas-phase N-2 and for higher coverages of oxygen, not bound at all. For equal concentrations of oxygen and nitrogen, this arrangement saturates at 2/3 monolayer of nitrogen and oxygen above which coverage the N-2 is displaced by atomic oxygen. A higher-energy surface can be formed from the adsorption of NO molecules. This saturates all of the silicon-surface states at 1/3 monolayer. Above this coverage a second phase consisting of N2O2 saturates all of the surface states at 1 monolayer and could conceivably be formed by adsorbing 1/2 monolayer of N-2 onto an oxygen-saturated 4H-SiC silicon surface. Interestingly our study shows that the 1 monolayer coverage of NO leaves the bulk band gap free of states. This has implications for growth of nitrogen on the silicon surface in the presence of oxygen. C1 [Ashman, Christopher R.] High Performance Technol Inc, Reston, VA 20190 USA. [Pennington, Gary] USA, Res Lab, Adelphi, MD 20783 USA. RP Ashman, CR (reprint author), High Performance Technol Inc, 11955 Freedom Dr,Suite 1100, Reston, VA 20190 USA. EM chris.r.ashman@gmail.com NR 43 TC 7 Z9 7 U1 1 U2 9 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 EI 1550-235X J9 PHYS REV B JI Phys. Rev. B PD AUG PY 2009 VL 80 IS 8 AR 085318 DI 10.1103/PhysRevB.80.085318 PG 16 WC Physics, Condensed Matter SC Physics GA 492FC UT WOS:000269639300079 ER PT J AU Pan, E Zou, Y Chung, PW Zhang, Y AF Pan, Ernie Zou, Yu Chung, Peter W. Zhang, Yan TI Interlayer correlation of embedded quantum-dot arrays through their surface strain energy distributions SO PHYSICAL REVIEW B LA English DT Article ID LATERAL CORRELATIONS; HALF-SPACE; SUPERLATTICES; ISLANDS; GROWTH; ORGANIZATION; FIELDS AB We propose an interlayer correlation of multilayer quantum-dot (QD) distributions from a rigorous strain energy calculation. This leads to a map of correlations, or interlayer alignment, based solely on lateral and vertical spacing (xdist/b versus hdist/h). We identify four distinct correlation regimes-aligned correlation, antialigned correlation, noncorrelation, and the transition zone between the aligned and antialigned correlation. Our prediction matches well with available experimental data for a broad range of semiconductors with low elastic anisotropy [A = 2C(44)/(C(11)-C(12)) < 2] and can further predict the QD array distribution for those with high elastic anisotropy (A >= 2) by a simple shift in hdist/h. The agreement spans both IV-VI and III-V systems. Moreover, the aligned correlation regime produces a large decay in strain energy magnitudes in subsequently grown layers, which may contribute to their observed larger nucleation domains. C1 [Pan, Ernie; Zou, Yu; Zhang, Yan] Univ Akron, Comp Modeling & Simulat Grp, Coll Engn, Akron, OH 44325 USA. [Chung, Peter W.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Pan, E (reprint author), Univ Akron, Comp Modeling & Simulat Grp, Coll Engn, Akron, OH 44325 USA. EM pan2@uakron.edu RI Pan, Ernian/F-4504-2011 OI Pan, Ernian/0000-0001-6640-7805 FU National Natural Science Foundation of China [10772106]; Defense Threat Reduction Agency Joint Science and Technology Office (DTRA-JSTO) [W911NF-06-2-0038]; Ohio Supercomputer Center [PBS0268-2] FX This work was partially supported by the National Natural Science Foundation of China Grant No. 10772106 (E.P.), and the Defense Threat Reduction Agency Joint Science and Technology Office (DTRA-JSTO) under Grant No. W911NF-06-2-0038 (P.W.C., E. P., Y. Zhang, and Y. Zou). We are also grateful to the Ohio Supercomputer Center for providing us with the required computer resource units under Grant No. PBS0268-2. NR 22 TC 3 Z9 3 U1 1 U2 3 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD AUG PY 2009 VL 80 IS 7 AR 073302 DI 10.1103/PhysRevB.80.073302 PG 4 WC Physics, Condensed Matter SC Physics GA 492EY UT WOS:000269638900008 ER PT J AU Turalska, M Lukovic, M West, BJ Grigolini, P AF Turalska, Malgorzata Lukovic, Mirko West, Bruce J. Grigolini, Paolo TI Complexity and synchronization SO PHYSICAL REVIEW E LA English DT Article DE decision making; large-scale systems; stochastic processes; synchronisation ID DECISION-MAKING; BROWNIAN-MOTION; QUANTUM DOTS; NETWORKS; OSCILLATORS; INFORMATION; PROPERTY; BEHAVIOR; PHYSICS; MODEL AB We study a fully connected network (cluster) of interacting two-state units as a model of cooperative decision making. Each unit in isolation generates a Poisson process with rate g. We show that when the number of nodes is finite, the decision-making process becomes intermittent. The decision-time distribution density is characterized by inverse power-law behavior with index mu=1.5 and is exponentially truncated. We find that the condition of perfect consensus is recovered by means of a fat tail that becomes more and more extended with increasing number of nodes N. The intermittent dynamics of the global variable are described by the motion of a particle in a double well potential. The particle spends a portion of the total time tau(S) at the top of the potential barrier. Using theoretical and numerical arguments it is proved that tau(S)proportional to(1/g)ln(constxN). The second portion of its time, tau(K), is spent by the particle at the bottom of the potential well and it is given by tau(K)=(1/g)exp(constxN). We show that the time tau(K) is responsible for the Kramers fat tail. This generates a stronger ergodicity breakdown than that generated by the inverse power law without truncation. We establish that the condition of partial consensus can be transmitted from one cluster to another provided that both networks are in a cooperative condition. No significant information transmission is possible if one of the two networks is not yet self-organized. We find that partitioning a large network into a set of smaller interacting clusters has the effect of converting the fat Kramers tail into an inverse power law with mu=1.5. C1 [Turalska, Malgorzata; Grigolini, Paolo] Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA. [Lukovic, Mirko; Grigolini, Paolo] Univ Pisa, Dipartimento Fis E Fermi, I-56127 Pisa, Italy. [Lukovic, Mirko; Grigolini, Paolo] INFM, I-56127 Pisa, Italy. [West, Bruce J.] USA, Res Off, Math & Informat Sci Directorate, Res Triangle Pk, NC 27709 USA. [Grigolini, Paolo] CNR, Area Ric, Ist Proc Chim Fis, I-56124 Pisa, Italy. RP Turalska, M (reprint author), Univ N Texas, Ctr Nonlinear Sci, POB 311427, Denton, TX 76203 USA. RI West, Bruce/E-3944-2017 FU U.S. Army Research Office [W911NF-08-1-0177] FX We gratefully acknowledge the financial support of the U.S. Army Research Office (Grant No. W911NF-08-1-0177). NR 38 TC 40 Z9 40 U1 0 U2 8 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2470-0045 EI 2470-0053 J9 PHYS REV E JI Phys. Rev. E PD AUG PY 2009 VL 80 IS 2 AR 021110 DI 10.1103/PhysRevE.80.021110 PN 1 PG 12 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA 492EP UT WOS:000269637800020 PM 19792080 ER PT J AU Weber, NS Cowan, DN Millikan, AM Niebuhr, DW AF Weber, Natalya S. Cowan, David N. Millikan, Amy M. Niebuhr, David W. TI Psychiatric and General Medical Conditions Comorbid With Schizophrenia in the National Hospital Discharge Survey SO PSYCHIATRIC SERVICES LA English DT Article; Proceedings Paper CT Annual Meeting of the American-Psychiatric-Association-Institute-of-Psychiatric-Services CY OCT 02-05, 2008 CL Chicago, IL SP Amer Psychiat Assoc, Inst Psychiat Serv ID SEVERE MENTAL-ILLNESS; SUBSTANCE-ABUSE; CARDIOVASCULAR-DISEASE; BIRTH COHORT; PRIMARY-CARE; HEPATITIS-C; LIFE-STYLE; DISORDERS; MORTALITY; RISK AB Objective: Morbidity and mortality from general medical conditions are elevated among patients with schizophrenia compared with the general U. S. population. More than 50% of patients with schizophrenia have one or more comorbid psychiatric or general medical conditions. This study determined types of comorbid disorders and their prevalence among hospitalized patients with and without schizophrenia. Methods: Data from the National Hospital Discharge Survey, a nationally representative sample, were analyzed for 1979-2003 (N=5,733,781 discharges). For discharges of patients aged 15 to 64 with at least one comorbid condition, the conditions of those with a primary diagnosis of schizophrenia (N=26,279) were compared with those with other primary diagnoses (N=1,936,876). Proportional morbidity ratios (PMRs) were calculated. Results: The proportion of discharges listing schizophrenia, particularly schizoaffective disorder, increased significantly over time among both males and females. The proportion was higher among males, blacks, and discharges in the Northeast. Discharge records with a primary diagnosis of schizophrenia showed higher proportions of all comorbid psychiatric conditions examined and of some general medical conditions, including acquired hypothyroidism (PMR=2.9), contact dermatitis and other eczema (PMR=2.9), obesity (PMR=2.0), epilepsy (PMR=2.0), viral hepatitis (PMR=1.4), diabetes type II (PMR=1.2), essential hypertension (PMR=1.2), and various chronic obstructive pulmonary diseases (PMR range 1.2-1.5). Conclusions: Knowledge of the risks of comorbid psychiatric and general medical conditions is critical both for clinicians and for patients with schizophrenia. Closer attention to prevention, early diagnosis, and treatment of comorbid conditions may decrease associated morbidity and mortality and improve prognosis among patients with schizophrenia. (Psychiatric Services 60: 1059-1067, 2009) C1 [Weber, Natalya S.; Cowan, David N.; Millikan, Amy M.; Niebuhr, David W.] Walter Reed Army Inst Res, Dept Epidemiol, Silver Spring, MD 20910 USA. RP Weber, NS (reprint author), Walter Reed Army Inst Res, Dept Epidemiol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM natalya.weber@amedd.army.mil RI Niebuhr, David/B-7865-2011 NR 71 TC 41 Z9 43 U1 4 U2 8 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 1075-2730 EI 1557-9700 J9 PSYCHIAT SERV JI Psychiatr. Serv. PD AUG 1 PY 2009 VL 60 IS 8 BP 1059 EP 1067 PG 9 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychiatry SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychiatry GA 477RU UT WOS:000268537000010 PM 19648193 ER PT J AU Torres, A Bentley, T Bartels, J Sarkar, J Barclay, D Namas, R Constantine, G Zamora, R Puyana, JC Vodovotz, Y AF Torres, Andres Bentley, Timothy Bartels, John Sarkar, Joydeep Barclay, Derek Namas, Rajaie Constantine, Gregory Zamora, Ruben Puyana, Juan Carlos Vodovotz, Yoram TI MATHEMATICAL MODELING OF POSTHEMORRHAGE INFLAMMATION IN MICE: STUDIES USING A NOVEL, COMPUTER-CONTROLLED, CLOSED-LOOP HEMORRHAGE APPARATUS SO SHOCK LA English DT Article DE Mouse; hemorrhagic shock; inflammation; mathematical model ID NITRIC-OXIDE; HYPOTENSIVE RESUSCITATION; MULTIPLE HEMORRHAGES; PRECLINICAL MODELS; IN-SILICO; SHOCK; TRAUMA; SEPSIS; INTERLEUKIN-10; INJURY AB Hemorrhagic shock (HS) elicits a global acute inflammatory response, organ dysfunction, and death. We have used mathematical modeling of inflammation and tissue damage/dysfunction to gain insight into this complex response in mice. We sought to increase the fidelity of our mathematical model and to establish a platform for testing predictions of this model. Accordingly, we constructed a computerized, closed-loop system for mouse HS. The intensity, duration, and time to achieve target MAP could all be controlled using a software. Fifty-four male C57/black mice either were untreated or underwent surgical cannulation. The cannulated mice were divided into 8 groups: (a) 1, 2, 3, or 4 h of surgical cannulation alone and b) 1, 2, 3, or 4 h of cannulation + HS (25 mmHg). MAP was sustained by the computer-controlled reinfusion and withdrawal of shed blood within +/- 2 mmHg. Plasma was assayed for the cytokines TNF, IL-6, and IL-10 as well as the NO reaction products NO(2)(-)/NO(3)(-). The cytokine and NO(2)(-)/NO(3)(-) data were compared with predictions from a mathematical model of post-hemorrhage inflammation, which was calibrated on different data. To varying degrees, the levels of TNF, IL-6, IL-10, and NO(2)(-)/NO(3)(-) predicted by the mathematical model matched these data closely. In conclusion, we have established a hardware/software platform that allows for highly accurate, reproducible, and mathematically predictable HS in mice. C1 [Torres, Andres; Barclay, Derek; Namas, Rajaie; Zamora, Ruben; Puyana, Juan Carlos; Vodovotz, Yoram] Univ Pittsburgh, Dept Surg, Sch Med, Pittsburgh, PA 15213 USA. [Bentley, Timothy] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 USA. [Puyana, Juan Carlos] Univ Pittsburgh, Dept Crit Care Med, Sch Med, Pittsburgh, PA 15213 USA. [Puyana, Juan Carlos; Vodovotz, Yoram] Univ Pittsburgh, McGowan Inst Regenerat Med, Ctr Inflammat & Regenerat Modeling, Pittsburgh, PA 15213 USA. [Constantine, Gregory] Univ Pittsburgh, Sch Med, Dept Math, Pittsburgh, PA 15213 USA. [Bartels, John; Sarkar, Joydeep] Immunetr Inc, Pittsburgh, PA USA. RP Vodovotz, Y (reprint author), Univ Pittsburgh, Dept Surg, Sch Med, W944 Biomed Sci Tower,200 Lothrop St, Pittsburgh, PA 15213 USA. EM vodovotz@upmc.edu OI Namas, Rajaie/0000-0003-0353-895X FU National Institutes of Health [P50-GM-53789, R01-HL-76157] FX This work was supported by the National Institutes of Health grains P50-GM-53789 (to Y.V.) and R01-HL-76157 (to Y,V. and J.C.P.) and grams from the Pittsburgh Life Sciences Greenhouse. the Commonwealth of Pennsylvania (YV), and the Pittsburgh Tissue Engineering Initiative (to Y.V.). NR 44 TC 28 Z9 29 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD AUG PY 2009 VL 32 IS 2 BP 172 EP 178 DI 10.1097/SHK.0b013e318193cc2b PG 7 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 480PM UT WOS:000268748400008 PM 19008782 ER PT J AU Powers, CR Frey, WC AF Powers, Christopher R. Frey, William C. TI Maintenance of wakefulness test in military personnel with upper airway resistance syndrome and mild to moderate obstructive sleep apnea SO SLEEP AND BREATHING LA English DT Article DE Sleep-disordered breathing; Hypersomnia; Sleep monitoring ID EXCESSIVE DAYTIME SLEEPINESS; LATENCY; ADULTS AB Sleep-disordered breathing (SDB) and the associated symptom of excessive daytime sleepiness (EDS) in military personnel has influential consequences in both the garrison and the deployed environments. The maintenance of wakefulness test (MWT) is a daytime study used to evaluate the tendency to stay awake. We evaluated consecutive patients diagnosed with mild to moderate obstructive sleep apnea (OSA) and upper airway resistance syndrome (UARS) to provide an objective measure of their EDS using the MWT. All military personnel referred between February 2004 and March 2005 with a clinical evaluation suspicious for SDB were evaluated with an overnight polysomnography (PSG). After overnight PSG, military personnel with mild to moderate OSA and UARS were evaluated with a 40-min protocol MWT. Abnormal MWT was defined as sleep onset latency mean below 19.4 min (< 2 SD below the mean). Sixty-two military personnel met entry criteria. Fifty-nine were men. Nineteen patients (32%) were diagnosed with UARS with a mean respiratory disturbance index of 11/h (5-20/h). Forty-one (68%) of the military personnel had OSA with a mean apnea-hypopnea index of 12/h (5-29/h). As a collective group, the mean Epworth Sleepiness Scale was elevated at 13/24 (1-24). This subjective excessive sleepiness was assessed with the MWT test, which resulted in a group mean MWT sleep onset latency of 27 min (5-40 min). Eighteen soldiers (30% of the total patients) had abnormal MWTs [six patients (33.3%) with UARS and 12 (67%) with OSA]. Military personnel with mild to moderate OSA and UARS often have abnormal MWTs and therefore have a pathological tendency to fall asleep. This EDS could pose a safety hazard in those personnel, military or civilian, who operate dangerous vehicles, machinery, or carry a firearm. Military personnel with untreated SDB are also at risk for the consequences of decreased mental alertness and decreased cognitive functioning due to daytime sleepiness. C1 [Powers, Christopher R.] William Beaumont Army Med Ctr, Pulm Crit Care & Sleep Med Serv, El Paso, TX 79920 USA. [Frey, William C.] Brooke Army Med Ctr, San Antonio, TX USA. RP Powers, CR (reprint author), William Beaumont Army Med Ctr, Pulm Crit Care & Sleep Med Serv, 5005 N Piedras St, El Paso, TX 79920 USA. EM christopher.r.powers@amedd.army.mil; william.c.frey@us.army.mil NR 19 TC 4 Z9 4 U1 0 U2 4 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1520-9512 J9 SLEEP BREATH JI Sleep Breath. PD AUG PY 2009 VL 13 IS 3 BP 253 EP 258 DI 10.1007/s11325-009-0245-7 PG 6 WC Clinical Neurology; Respiratory System SC Neurosciences & Neurology; Respiratory System GA 460XD UT WOS:000267224100006 PM 19229578 ER PT J AU Kristo, DA Shah, AA Lettieri, CJ MacDermott, SM Andrada, T Taylor, Y Eliasson, AH AF Kristo, David A. Shah, Anita A. Lettieri, Christopher J. MacDermott, Sean M. Andrada, Teotimo Taylor, Yvonne Eliasson, Arn H. TI Utility of split-night polysomnography in the diagnosis of upper airway resistance syndrome SO SLEEP AND BREATHING LA English DT Article DE Upper airway resistance syndrome; Sleep-disordered breathing; Split-night polysomnography; Esophageal manometry; Hypersomnolence; Excessive daytime sleepiness; Increased upper airway resistance; Obstructive sleep apnea ID OBSTRUCTIVE SLEEP-APNEA; DAYTIME SLEEPINESS AB Split-night polysomnography can both establish the diagnosis and titrate continuous positive airway pressure (CPAP) during a single study in patients with sleep-disordered breathing. We sought to determine if split-night polysomnography could be effectively used in upper airway resistance syndrome (UARS) without diminishing diagnostic accuracy or success of CPAP titration. Consecutive patients diagnosed with UARS were included. Split-night studies were performed in patients meeting predefined criteria. We compared data between those undergoing traditional and split-night polysomnography. We included 100 consecutive patients (41.2 +/- 7.4 years, 54% men). Forty-six underwent split-night polysomnography. Groups were similar at baseline. There were no differences in polysomnography or success rate of CPAP titration. Among those not undergoing split-night studies, the mean time between diagnostic polysomnography and CPAP titration was 71.9 +/- 49.0 days. Split-night polysomnography can be effectively utilized to diagnose UARS and initiate CPAP therapy. This practice can reduce the number of studies needed and obviate the inherent delay in initiating CPAP therapy. C1 [Kristo, David A.; Shah, Anita A.; Lettieri, Christopher J.; MacDermott, Sean M.; Andrada, Teotimo; Taylor, Yvonne; Eliasson, Arn H.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Lettieri, CJ (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM christopher.lettieri@us.army.mil NR 13 TC 3 Z9 3 U1 0 U2 0 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1520-9512 J9 SLEEP BREATH JI Sleep Breath. PD AUG PY 2009 VL 13 IS 3 BP 271 EP 275 DI 10.1007/s11325-008-0235-1 PG 5 WC Clinical Neurology; Respiratory System SC Neurosciences & Neurology; Respiratory System GA 460XD UT WOS:000267224100009 PM 19052789 ER PT J AU Upasani, VV Chambers, RC Dalal, AH Shah, SA Lehman, RA Newton, PO AF Upasani, Vidyadhar V. Chambers, Reid C. Dalal, Ali H. Shah, Suken A. Lehman, Ronald A., Jr. Newton, Peter O. TI Grading Apical Vertebral Rotation Without a Computed Tomography Scan A Clinically Relevant System Based on the Radiographic Appearance of Bilateral Pedicle Screws SO SPINE LA English DT Article DE apical vertebral rotation; trigonometric model; adolescent idiopathic scoliosis ID ADOLESCENT IDIOPATHIC SCOLIOSIS; POSTERIOR SPINAL-FUSION; RIB CAGE DEFORMITY; AXIAL ROTATION; SURGICAL-CORRECTION; THORACIC SCOLIOSIS; CT SCANS; INSTRUMENTATION; CURVE; CONSTRUCTS AB Study Design. Bench-top and retrospective analysis to assess vertebral rotation based on the appearance of bilateral pedicle screws in patients with adolescent idiopathic scoliosis (AIS). Objective. To develop a clinically relevant radiographic grading system for evaluating postoperative thoracic apical vertebral rotation that would correlate with computed tomography (CT) measures of rotation. Summary of Background Data. The 3-column vertebral body control provided by bilateral pedicle screws has enabled scoliosis surgeons to develop advanced techniques of direct vertebral derotation. Our ability to accurately quantify spinal deformity in the axial plane, however, continues to be limited. Methods. Trigonometry was used to define the relationship between the position of bilateral pedicle screws and vertebral rotation. This relationship was validated using digital photographs of a bench-top model. The mathematical relationships were then used to calculate vertebral rotation from standing postoperative, posteroanterior radiographs in AIS patients and correlated with postoperative CT measures of rotation. Results. Fourteen digital photographs of the benchtop model were independently analyzed twice by 3 coauthors. The mathematically calculated degree of rotation was found to correlate significantly with the actual degree of rotation (r = 0.99; P < 0.001) and the intra-and inter-observer reliability for these measurements were both excellent (k = 0.98 and k = 0.97, respectively). In the retrospective analysis of 17 AIS patients, the average absolute difference between the radiographic measurement of rotation and the CT measure was only 1.9 +/- 2.0 degrees (r = 0.92; P < 0.001). Based on these correlations a simple radiographic grading system for postoperative apical vertebral rotation was developed. Conclusion. An accurate assessment of vertebral rotation can be performed radiographically, using screw lengths and screw tip-to-rod distances of bilateral segmental pedicle screws and a trigonometric calculation. These data support the use of a simple radiographic grading system to approximate apical vertebral rotation in AIS patients treated with bilateral apical pedicle screws. C1 [Upasani, Vidyadhar V.; Dalal, Ali H.; Newton, Peter O.] Univ Calif San Diego, Dept Orthoped Surg, San Diego, CA 92103 USA. [Chambers, Reid C.; Newton, Peter O.] Rady Childrens Hosp & Hlth Ctr, Dept Orthoped Surg, San Diego, CA USA. [Shah, Suken A.] Alfred I duPont Hosp Children, Dept Orthoped Surg, Wilmington, DE USA. [Lehman, Ronald A., Jr.] Walter Reed Army Med Ctr, Dept Orthoped Surg, Washington, DC 20307 USA. RP Newton, PO (reprint author), 3030 Childrens Way,Suite 410, San Diego, CA 92123 USA. EM pnewton@rchsd.org FU Rady Children's Specialists Foundation Orthopedic Research and Education Fund FX Supported in part by a research grant from DePuy Spine Inc. and in part by the Rady Children's Specialists Foundation Orthopedic Research and Education Fund. NR 54 TC 10 Z9 12 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD AUG 1 PY 2009 VL 34 IS 17 BP 1855 EP 1862 DI 10.1097/BRS.0b013e3181abf797 PG 8 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 480GH UT WOS:000268720000016 PM 19644337 ER PT J AU DiPaolo, BP Tom, JG AF DiPaolo, B. P. Tom, J. G. TI Effects of ambient temperature on a quasi-static axial-crush configuration response of thin-wall, steel box components SO THIN-WALLED STRUCTURES LA English DT Article DE Axial crush; Steel; Plastic deformation; Energy absorption; Quasi-static; Ambient temperature ID IMPACT ENERGY ABSORBERS; SQUARE TUBES; ALUMINUM EXTRUSIONS; STAINLESS-STEEL; SHEET STEELS; ABSORPTION; COLLAPSE; COMPRESSION; BEHAVIOR; LOAD AB An experimental investigation was performed to study the effects of ambient temperature on axial-crush response of steel, square box components. Test specimens were obtained from commercially produced, welded tube lengths of ASTM A36 and ASTM A513 Type 1 plain low-carbon steels and AISI 316 and AISI 304 austenitic stainless steels. Quasi-static testing was performed at different temperatures using a universal testing machine with an environmental chamber. Removable grooved caps for end constraints and collapse initiators in the form of shallow-machined groove patterns on specimen sidewalls were used to restrict the response of the test specimens to a specific configuration (fold-formation process and the corresponding axial load-axial displacement curve shape) of the symmetric axial-crush response mode. Overall, results indicate that, for three ambient temperatures within automotive thermal operating conditions. axial crush can be restricted to a specific configuration response and a controlled and repeatable energy-absorption process can be obtained. However, depending on the material type, secondary folding-phase load and energy-absorption crush characteristics can be significantly influenced by ambient temperature. Published by Elsevier Ltd. C1 [DiPaolo, B. P.; Tom, J. G.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP DiPaolo, BP (reprint author), USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM Beverly.P.DiPaolo@usace.army.mil FU Empire Metal Supply, Inc. FX The authors wish to extend our appreciation to Mr. Matt Shaw, Empire Metal Supply, Inc., for his continuing help in obtaining the AISI 316 stainless steel tube lengths and the ERDC Directorate of Public Works machine shop and model shop personnel for their fine efforts in specimen preparation. We also gratefully acknowledge the support and encouragement of the research work by Dr. Robert L. Hall, Dr. David A. Horner, and Dr. Reed L. Mosher, ERDC. Permission to publish was granted by the Director, Geotechnical and Structures Laboratory, ERDC. Approved for public release; distribution is unlimited. NR 81 TC 3 Z9 3 U1 0 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0263-8231 J9 THIN WALL STRUCT JI Thin-Walled Struct. PD AUG-SEP PY 2009 VL 47 IS 8-9 BP 984 EP 997 DI 10.1016/j.tws.2009.01.007 PG 14 WC Engineering, Civil SC Engineering GA 454HH UT WOS:000266672500016 ER PT J AU Rushing, SR Saylor, ML Hale, ML AF Rushing, S. Renee Saylor, Michelle L. Hale, Martha L. TI Translocation of ricin across polarized human bronchial epithelial cells SO TOXICON LA English DT Article DE Ricin; Transcytosis; Translocation; Bronchial epithelial cells; Inhalational toxicity ID VASCULAR LEAK SYNDROME; INHALATION EXPOSURE; TRANSCYTOSIS; TOXIN; ENDOCYTOSIS; EXPRESSION; MECHANISM; TRANSPORT; BARRIERS; TRIGGERS AB Due to widespread availability, toxicity, and potential for use as a bioterrorism agent, ricin is classified as a category B select agent. While ricin can be internalized by a number of routes, inhalation is particularly problematic. The resulting damage leads to irreversible pulmonary edema and death. Our study describes a model system developed to investigate the effects of ricin on respiratory epithelium. Human bronchial epithelial (HBE) cells were cultured on collagen IV-coated inserts until polarized epithelial cell monolayers developed. Ricin was added to the apical or basal medium and damage to the cell monolayer was then assessed. Within a few hours after exposure, the cell monolayer was permeable to paracellular passage of the toxin. A mouse anti-ricin antibody neutralized ricin and prevented cellular damage as long as the antibody was present before the addition of toxin. These studies suggested that effective therapeutic agents or antibodies neutralizing ricin biological activity must be present at the apical surface of epithelial cells. The in vitro system developed here provides a method by which to screen potential therapeutics for protecting lung epithelial cells against ricin intoxication. Published by Elsevier Ltd. C1 [Saylor, Michelle L.; Hale, Martha L.] USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. [Rushing, S. Renee] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. RP Hale, ML (reprint author), USA, Med Res Inst Infect Dis, Integrated Toxicol Div, 1425 Porter St, Ft Detrick, MD 21702 USA. EM martha.hale@amedd.army.mil FU DTRA [133249] FX We are very grateful to Dr. Gordon Ruthel for technical advice and for providing the micrographs of our samples. This work was funded by DTRA Research Plan #133249. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by The United States Army. NR 26 TC 2 Z9 2 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD AUG PY 2009 VL 54 IS 2 BP 184 EP 191 DI 10.1016/j.toxicon.2009.04.003 PG 8 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 461YE UT WOS:000267309500012 PM 19374915 ER PT J AU Summers, T Johnson, VV Stephan, JP Johnson, GJ Leonard, G AF Summers, Thomas, Jr. Johnson, Viviana V. Stephan, John P. Johnson, Gloria J. Leonard, George TI The value of automated gel column agglutination technology in the identification of true inherited D blood types in massively transfused patients SO TRANSFUSION LA English DT Article ID PHASE ANTIGLOBULIN-TEST; BANK AB BACKGROUND: Massive transfusion of D- trauma patients in the combat setting involves the use of D+ red blood cells (RBCs) or whole blood along with suboptimal pretransfusion test result documentation. This presents challenges to the transfusion service of tertiary care military hospitals who ultimately receive these casualties because initial D typing results may only reflect the transfused RBCs. After patients are stabilized, mixed-field reaction results on D typing indicate the patient's true inherited D phenotype. This case series illustrates the utility of automated gel column agglutination in detecting mixed-field reactions in these patients. STUDY DESIGN AND METHODS: The transfusion service test results, including the automated gel column agglutination D typing results, of four massively transfused D- patients transfused D+ RBCs is presented. To test the sensitivity of the automated gel column agglutination method in detecting mixed-field agglutination reactions, a comparative analysis of three automated technologies using predetermined mixtures of D+ and D- RBCs is also presented. RESULTS: The automated gel column agglutination method detected mixed-field agglutination in D typing in all four patients and in the three prepared control specimens. The automated microwell tube method identified one of the three prepared control specimens as indeterminate, which was subsequently manually confirmed as a mixed-field reaction. The automated solid-phase method was unable to detect any mixed fields. CONCLUSION: The automated gel column agglutination method provides a sensitive means for detecting mixed-field agglutination reactions in the determination of the true inherited D phenotype of combat casualties transfused massive amounts of D+ RBCs. C1 [Leonard, George] Walter Reed Army Med Ctr, Transfus Serv, Dept Anat Pathol, Washington, DC 20307 USA. Natl Naval Med Ctr, Transfus Med Serv, Bethesda, MD USA. Natl Capital Consortium Pathol Residency Program, Bethesda, MD USA. RP Leonard, G (reprint author), Walter Reed Army Med Ctr, Transfus Serv, Dept Anat Pathol, Ward 47,6900 Georgia Ave NW, Washington, DC 20307 USA. EM george.leonard@amedd.army.mil NR 18 TC 1 Z9 1 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD AUG PY 2009 VL 49 IS 8 BP 1672 EP 1677 DI 10.1111/j.1537-2995.2009.02194.x PG 6 WC Hematology SC Hematology GA 478LS UT WOS:000268590400021 PM 19413733 ER PT J AU Barker, WC Mazumder, R Vasudevan, S Sagripanti, JL Wu, CH AF Barker, Winona C. Mazumder, Raja Vasudevan, Sona Sagripanti, Jose-Luis Wu, Cathy H. TI Sequence signatures in envelope protein may determine whether flaviviruses produce hemorrhagic or encephalitic syndromes SO VIRUS GENES LA English DT Article DE Flavivirus; Envelope protein; Hemorrhagic disease; Encephalitis; Sequence signature; Dengue; Yellow fever; West Nile; St. Louis encephalitis; Tick-borne encephalitis; Japanese encephalitis; Kyasanur forest disease; Omsk hemorrhagic fever ID TICK-BORNE ENCEPHALITIS; N-LINKED GLYCOSYLATION; PHYLOGENETIC-RELATIONSHIPS; POWASSAN VIRUS; SAUDI-ARABIA; IN-VITRO; FEVER; ELECTROSTATICS; TRANSMISSION; PATHOGENESIS AB We analyzed the envelope proteins in pathogenic flaviviruses to determine whether there are sequence signatures associated with the tendency of viruses to produce hemorrhagic disease (H-viruses) or encephalitis (E-viruses). We found that, at the position corresponding to the glycosylated Asn-67 in dengue virus, asparagine (Asn) occurs in all seven viral species that cause hemorrhagic disease in humans. Furthermore, Asn was extremely rare at position 67 in six flaviviruses that cause encephalitis, being replaced by Asp in four of them. Of the 3,246 sequences from H- and E-viruses, we found that 2,916 sequences (90%) contained Asn in position 67 for H-viruses or Asp in position 67 for E-viruses. The change from Asn-67 that is prevalent in H-viruses to Asp-67 (common in E-viruses) contributes to a stronger electrostatically negative surface in the E-viruses as compared to the H-viruses. These findings should help predicting the disease potential of emerging and re-emerging flaviviruses and understanding the relationship between protein structure and disease outcome. C1 [Sagripanti, Jose-Luis] US Army, Edgewood Chem Biol Ctr, ATTN AMSRD ECB RT, Aberdeen Proving Ground, MD 21010 USA. [Barker, Winona C.; Mazumder, Raja; Vasudevan, Sona; Wu, Cathy H.] Georgetown Univ, Dept Biochem & Mol & Cellular Biol, Med Ctr, Washington, DC 20007 USA. RP Sagripanti, JL (reprint author), US Army, Edgewood Chem Biol Ctr, ATTN AMSRD ECB RT, Aberdeen Proving Ground, MD 21010 USA. EM joseluis.sagripanti@us.army.mil RI Crozier, Laura/A-4821-2010 FU U.S. Department of Defense Chemical and Biological Defense FX This work was supported by the U.S. Department of Defense Chemical and Biological Defense program administered by the Defense Threat Reduction Agency and by In-House Laboratory Independent Research (ILIR) funds from the Research and Technology Directorate, Edgewood Chemical Biological Center, Research Development and Engineering Command, US Army. This research was performed while WCB held a National Research Council Research Associateship Award sponsored by the U.S. Army Edgewood Chemical Biological Center. We thank Dr. Hongzhan Huang and Dr. C. R. Vinayaka from Protein Information Resource for providing the statistical analysis and for designing Fig. 1c, respectively. NR 38 TC 8 Z9 8 U1 0 U2 3 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0920-8569 J9 VIRUS GENES JI Virus Genes PD AUG PY 2009 VL 39 IS 1 BP 1 EP 9 DI 10.1007/s11262-009-0343-4 PG 9 WC Genetics & Heredity; Virology SC Genetics & Heredity; Virology GA 461VI UT WOS:000267299900001 PM 19283462 ER PT J AU Wagner, GW Fry, RA AF Wagner, George W. Fry, Roderick A. TI Observation of Distinct Surface Al-IV Sites and Phosphonate Binding Modes in gamma-Alumina and Concrete by High-Field Al-27 and P-31 MAS NMR SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID QUADRUPOLAR NUCLEI; NANOSIZE AL2O3; VX; HD; GD; ACID; DECOMPOSITION; DEHYDRATION; GAMMA-AL2O3; DEGRADATION AB High loadings of nerve agent-related phosphonic acids adsorbed on gamma-Al2O3 and concrete examined by P-31 MAS NMR and high-field Al-27 MAS NMR reveal the presence of several phosphonate-surface binding modes and greatly improved resolution of multiple Al-IV sites. Some of the resolved Al-IV sites are sensitive to surface hydroxylation/dehydroxylation are attributed to surface Al-IV-OH groups (apparently having been observed for the first time). Although the number of surface Al-IV sites detected by high-field Al-27 MAS NMR (three) is in agreement with current surface models, their dehydroxylation behavior does not entirely concur with proposed dehydroxylation mechanisms. The various phosphonate-alumina surface species detected by P-31 MAS NMR are consistent with those previously observed by IR techniques. In concrete, the formation of an aluminophosphonate species is directly observed, consistent with the recalcitrant extraction behavior exhibited by adsorbed phosphonates in environmental matrices. C1 [Wagner, George W.] USA, Edgewood Chem Biol Ctr, Attn AMSRD ECB RT PF, Aberdeen Proving Ground, MD 21010 USA. [Fry, Roderick A.] SAIC, Gunpowder Branch, Aberdeen Proving Ground, MD 21010 USA. RP Wagner, GW (reprint author), USA, Edgewood Chem Biol Ctr, Attn AMSRD ECB RT PF, Aberdeen Proving Ground, MD 21010 USA. EM george.wagner@us.army.mil FU U.S. Department of Defense [W911NF0710053]; New York State Office of Science, Technology, and Academic Research; NIH [P41 GM66334]; Keck Foundation, New York State; NYC Economic Development Coporation FX Work performed at New York Structural Biology Center (NYSBC) was supported under U.S. Department of Defense Grant No. W911NF0710053. The Center is a STAR center supported by the New York State Office of Science, Technology, and Academic Research. NMR resources supported by NIH P41 GM66334. 900 MHz NMR spectrometers were purchased with funds from NIH, USA, the Keck Foundation, New York State, and the NYC Economic Development Coporation. Assistance with the high-field 27Al MAS NMR work by Dr. Boris Itin. NYSBC, is gratefully acknowledged, as are helpful discussions with Dr. Carol A. S. Brevctt, SAIC, regarding compositions of concrete and their interaction with G-agents. NR 30 TC 4 Z9 4 U1 1 U2 9 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD JUL 30 PY 2009 VL 113 IS 30 BP 13352 EP 13357 DI 10.1021/jp902474z PG 6 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 473TZ UT WOS:000268233800063 ER PT J AU Hoge, CW Goldberg, HM Castro, CA AF Hoge, Charles W. Goldberg, Herb M. Castro, Carl A. TI Care of War Veterans with Mild Traumatic Brain Injury REPLY SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter C1 [Hoge, Charles W.; Goldberg, Herb M.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Castro, Carl A.] USA, Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP Hoge, CW (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM charles.hoge@us.army.mil NR 6 TC 0 Z9 0 U1 1 U2 1 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD JUL 30 PY 2009 VL 361 IS 5 BP 537 EP 538 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 476LW UT WOS:000268443900034 ER PT J AU Tolle, J Roucka, R Forrest, B Chizmeshya, AVG Kouvetakis, J D'Costa, VR Poweleit, CD Groenert, M Sato, T Menendez, J AF Tolle, John Roucka, Radek Forrest, Brandon Chizmeshya, Andrew V. G. Kouvetakis, John D'Costa, Vijay R. Poweleit, Christian D. Groenert, Michael Sato, Taketomo Menendez, Jose TI Integration of Zn-Cd-Te-Se Semiconductors on Si Platforms via Structurally Designed Cubic Templates Based on Group IV Elements SO CHEMISTRY OF MATERIALS LA English DT Article ID MOLECULAR-BEAM-EPITAXY; FOCAL-PLANE ARRAYS; GROWTH; HGCDTE; EPILAYERS; PHASE; GAAS AB This work describes the development and application of a new class of highly versatile Ge-Sn/Si (100) hybrid substrate systems for the integration of a broad range of technologically important II-VI optical materials on silicon platforms. GeSn buffer layers were grown directly on Si(100), via introduction of Lomer edge dislocations at the interface, and exhibited low densities of threading defects, atomically flat surfaces, and strain-free microstructures. Specialized cleaning protocols were first developed to obtain GeSn surfaces possessing superior chemical purity and single-crystalline, long-range orientation for subsequent heteroepitaxy. The quality of the resulting platforms was then validated using proof-of-concept fabrication of prototype AlGaAs/GaAs/AlGaAs quantum well structures, which exhibited optical properties comparable to those of analogs grown via homoepitaxy on bulk GaAs substrates. The application of these platforms in CMOS-compatible integration of the II-VI materials was explored using a progressive strategy based on the systematic epitaxial fabrication of simple binaries within Zn-Cd-Te-Se class. This culminated in the Formation of fully lattice matched ZnSc/'GeSn/Si(100) structures for the first time, as well as highly mismatched CdTe and CdTe/ZnTe systems directly on silicon. These successful depositions represent an important milestone en route to the ultimate integration of ZnSe, CdTe, Zn(1-)zCd(z)Te and Hg(1-x)Cd(x)Te with Si for applications in high-performance IR photodetectors, imaging technologies, and high-efficiency, low-cost solar cells. C1 [Tolle, John; Roucka, Radek; Forrest, Brandon; Chizmeshya, Andrew V. G.; Kouvetakis, John] Arizona State Univ, Dept Chem & Biochem, Tempe, AZ 85287 USA. [Tolle, John] Silicon Photon Grp Inc, Gilbert, AZ 85233 USA. [D'Costa, Vijay R.; Poweleit, Christian D.; Menendez, Jose] Arizona State Univ, Dept Phys, Tempe, AZ 85287 USA. [Groenert, Michael] USA, RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. [Sato, Taketomo] Hokkaido Univ, Res Ctr Integrated Quantum Elect, Sapporo, Hokkaido 0608628, Japan. RP Kouvetakis, J (reprint author), Arizona State Univ, Dept Chem & Biochem, Tempe, AZ 85287 USA. RI Schaff, William/B-5839-2009; Menendez, Jose/C-1034-2009 OI Menendez, Jose/0000-0001-8739-9197 NR 25 TC 1 Z9 1 U1 1 U2 8 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0897-4756 J9 CHEM MATER JI Chem. Mat. PD JUL 28 PY 2009 VL 21 IS 14 BP 3143 EP 3152 DI 10.1021/cm900437y PG 10 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 473AD UT WOS:000268174400020 ER PT J AU Landrum, ML Hullsiek, KH Ganesan, A Weintrob, AC Crum-Cianflone, NF Barthel, RV Peel, S Agan, BK AF Landrum, Michael L. Hullsiek, Katherine Huppler Ganesan, Anuradha Weintrob, Amy C. Crum-Cianflone, Nancy F. Barthel, R. Vincent Peel, Sheila Agan, Brian K. TI Hepatitis B vaccine responses in a large US military cohort of HIV-infected individuals: Another benefit of HAART in those with preserved CD4 count SO VACCINE LA English DT Article; Proceedings Paper CT 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy/46th Annual Meeting of the Infectious-Diseases-Society-of-America CY OCT 25, 2008 CL Washington, DC SP Infect Dis Soc Amer DE Hepatitis B vaccine; Hepatitis B virus; Human immunodeficiency virus; Highly active antiretroviral therapy; Immunization ID ACTIVE ANTIRETROVIRAL THERAPY; HUMAN-IMMUNODEFICIENCY-VIRUS; LONG-TERM IMMUNOGENICITY; CELL COUNTS; ANTIBODY-RESPONSE; RISK-FACTORS; T-CELL; ADULTS; NONRESPONDERS; NORMALIZATION AB The influence of highly active antiretroviral therapy (HAART) upon hepatitis B virus (HBV) vaccine responses in HIV-infected individuals is unclear. After classification of vaccinees as non-responders (HBsAb <10IU/L) or responders (HBsAb >= 10IU/L) in our HIV cohort, multivariate logistic regression was used to assess factors associated with subsequent vaccine response. Of 626 participants vaccinated from 1988 to 2005, 217 (35%) were vaccine responders. Receipt of >= 3 doses of vaccine (OR 1.83, 95% CI 1.24-2.70), higher CD4 count at vaccination (OR 1.09, 95% CI 1.05-1.13 per 50 cells/mu l increase), and use of HAART (OR 2.37, 95% CI 1.56-3.62) were all associated with increased likelihood of developing a response. However, only 49% of those on HAART at last vaccination responded, and 62% of those on HAART, with CD4 count >= 350, and HIV RNA <400 copies/mL responded. Compared to those on HAART with CD4 count >= 350, those not on HAART with CD4 count >= 350 had significantly reduced odds of developing a vaccine response (OR 0.47, 95% CI 0.30-0.70). While HAART use concurrent with HBV immunization was associated with increased probability of responding to the vaccine, the response rate was low for those on HAART. These data provide additional evidence of HAART benefits, even in those with higher CD4 counts, but also highlight the need for improving HBV vaccine immunogenicity. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Landrum, Michael L.; Hullsiek, Katherine Huppler; Ganesan, Anuradha; Weintrob, Amy C.; Crum-Cianflone, Nancy F.; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD USA. [Landrum, Michael L.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Hullsiek, Katherine Huppler] Univ Minnesota, Minneapolis, MN USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Bethesda, MD USA. [Weintrob, Amy C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Crum-Cianflone, Nancy F.] USN, Med Ctr, San Diego, CA 92152 USA. [Barthel, R. Vincent] USN, Med Ctr, Portsmouth, CA 92152 USA. [Peel, Sheila] Walter Reed Army Inst Res, Div Retrovirol, Silver Spring, MD USA. RP Landrum, ML (reprint author), Brooke Army Med Ctr, Infect Dis Serv, MCHE MDI, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM mlandrum@idcrp.org OI Agan, Brian/0000-0002-5114-1669 FU NIAID NIH HHS [HU0001-05-2-0011]; PHS HHS [HU0001-05-2-0011] NR 45 TC 36 Z9 38 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JUL 23 PY 2009 VL 27 IS 34 BP 4731 EP 4738 DI 10.1016/j.vaccine.2009.04.016 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 475IG UT WOS:000268351200024 PM 19540026 ER PT J AU Orio, PF Merrick, GS Allen, ZA Butler, WM Wallner, KE Kurko, BS Galbreath, RW AF Orio, Peter F., III Merrick, Gregory S. Allen, Zachariah A. Butler, Wayne M. Wallner, Kent E. Kurko, Brian S. Galbreath, Robert W. TI cExternal beam radiation results in minimal changes in post void residual urine volumes during the treatment of clinically localized prostate cancer SO RADIATION ONCOLOGY LA English DT Article ID DOSE-ESCALATION; CONFORMAL RADIOTHERAPY; POSITION VARIABILITY; BLADDER; THERAPY; MOTION; TRIAL; PREDICTORS; ACCURACY; SCANNER AB Background: To evaluate the impact of external beam radiation therapy (XRT) on weekly ultrasound determined post-void residual (PVR) urine volumes in patients with prostate cancer. Methods: 125 patients received XRT for clinically localized prostate cancer. XRT was delivered to the prostate only (n = 66) or if the risk of lymph node involvement was greater than 10% to the whole pelvis followed by a prostate boost (n = 59). All patients were irradiated in the prone position in a custom hip-fix mobilization device with an empty bladder and rectum. PVR was obtained at baseline and weekly. Multiple clinical and treatment parameters were evaluated as predictors for weekly PVR changes. Results: The mean patient age was 73.9 years with a mean pre-treatment prostate volume of 53.3 cc, a mean IPSS of 11.3 and a mean baseline PVR of 57.6 cc. During treatment, PVR decreased from baseline in both cohorts with the absolute difference within the limits of accuracy of the bladder scanner. Alpha-blockers did not predict for a lower PVR during treatment. There was no significant difference in mean PVR urine volumes or differences from baseline in either the prostate only or pelvic radiation groups (p = 0.664 and p = 0.458, respectively). Patients with a larger baseline PVR (>40 cc) had a greater reduction in PVR, although the greatest reduction was seen between weeks one and three. Patients with a small PVR (<40 cc) had no demonstrable change throughout treatment. Conclusion: Prostate XRT results in clinically insignificant changes in weekly PVR volumes, suggesting that radiation induced bladder irritation does not substantially influence bladder residual urine volumes. C1 [Merrick, Gregory S.; Allen, Zachariah A.; Butler, Wayne M.; Kurko, Brian S.; Galbreath, Robert W.] Wheeling Jesuit Univ, Wheeling, WV 26003 USA. [Orio, Peter F., III] Brooke Army Med Ctr, Dept Radiat Oncol, Houston, TX 78234 USA. [Wallner, Kent E.] Univ Washington, Puget Sound Healthcare Corp Grp Hlth Cooperat, Seattle, WA 98108 USA. EM peter.orio@us.army.mil; gmerrick@urologicresearchinstitute.org; zallen@urologicresearchinstitute.org; wbutler@urologicresearchinstitute.org; kent.wallner@med.va.gov; bkurko@wheelinghospital.org; rgalbrea@wju.edu NR 26 TC 1 Z9 1 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA CURRENT SCIENCE GROUP, MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND J9 RADIAT ONCOL JI Radiat. Oncol. PD JUL 22 PY 2009 VL 4 AR 26 DI 10.1186/1748-717X-4-26 PG 9 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 487VJ UT WOS:000269305100001 PM 19624852 ER PT J AU Nersisyan, SR Tabiryan, NV Steeves, DM Kimball, BR AF Nersisyan, Sarik R. Tabiryan, Nelson V. Steeves, Diane M. Kimball, Brian R. TI Characterization of optically imprinted polarization gratings SO APPLIED OPTICS LA English DT Article ID LIQUID-CRYSTAL; DIFFRACTION; ANISOTROPY AB We provide detailed description and characterization of specifies of the imprinting technique for fabrication of large-area and high-efficiency liquid crystal polymer polarization gratings. We show that the quality of polarization gratings imprinted with linear polarized light is as high as that of gratings obtained in the holographic process, while exhibiting twice larger diffraction angle. The cycloidal polarization pattern used for imprinting is obtained from a master polarization grating, and the importance of fine tuning of its peak diffraction wavelength to the wavelength of imprinting radiation is emphasized. Tuning of the peak diffraction wavelength of imprinted polarization gratings from UV to near IR was realized with the aid of multilayer structures. Since the imprinting process does not involve a holographic setup, it is insensitive to ambient conditions and vibrations and provides an opportunity for large scale production of polarization gratings. (C) 2009 Optical Society of America C1 [Nersisyan, Sarik R.; Tabiryan, Nelson V.] BEAM Engn Adv Measurements Co, Winter Pk, FL 32789 USA. [Steeves, Diane M.; Kimball, Brian R.] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. RP Tabiryan, NV (reprint author), BEAM Engn Adv Measurements Co, 809 S Orlando Ave,Suite 1, Winter Pk, FL 32789 USA. EM nelson@beamco.com NR 17 TC 11 Z9 11 U1 1 U2 7 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JUL 20 PY 2009 VL 48 IS 21 BP 4062 EP 4067 DI 10.1364/AO.48.004062 PG 6 WC Optics SC Optics GA 483GC UT WOS:000268949800002 PM 19623219 ER PT J AU Cole, WP Marciniak, MA AF Cole, Walter P. Marciniak, Michael A. TI Path-averaged C-n(2) estimation using a laser-and-corner-cube system SO APPLIED OPTICS LA English DT Article ID ATMOSPHERIC OPTICAL TURBULENCE; INTENSITY; PROPAGATION; PARAMETERS; COMMUNICATION; SPECTRUM; LIGHT; BEAM; LAND AB As a finite cross-section laser beam propagates through the atmosphere, the beam spreads due to both diffraction and atmospheric turbulence effects. Using turbulence theory valid in both weak and strong optical turbulence regimes, a relationship between atmospheric beam spread and the resulting return power for an optical system and the refractive-index structure parameter or C-n(2) can be established. A technique for estimating the path-averaged C-n(2) using a laser-and-corner-cube system based on this relationship is described. Experimental results using near-infrared laser wavelengths show good agreement between theoretical predictions and scintillometer-measured C-n(2) values for near-ground line-of-sight propagation paths. (C) 2009 C1 [Cole, Walter P.; Marciniak, Michael A.] USAF, Inst Technol, Dept Engn Phys, Wright Patterson AFB, OH 45433 USA. RP Cole, WP (reprint author), US Mil Acad, Photon Res Ctr, Dept Phys, West Point, NY 10996 USA. EM walter.p.cole@us.army.mil OI Marciniak, Michael/0000-0003-2879-5565 FU Air Force Research Laboratory, Materials and Manufacturing Directorate (AFRL/RX) FX This work has been supported by the Air Force Research Laboratory, Materials and Manufacturing Directorate (AFRL/RX) at WPAFB. The authors would like to thank Shawn Davidson from General Dynamics for providing extensive support during the experimental testing, Anthony Cain, Ronald Perrin, and Capt Christopher Charles from AFRL/RX for equipment and data acquisition technical support, and Donald Thomas for computer and software technical support. The views expressed in this article are those of the author and do not reflect the official policy or position of the United States Army, United States Air Force, Department of Defense, or the United States Government. NR 46 TC 4 Z9 4 U1 0 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JUL 20 PY 2009 VL 48 IS 21 BP 4256 EP 4262 DI 10.1364/AO.48.004256 PG 7 WC Optics SC Optics GA 483GC UT WOS:000268949800023 PM 19623240 ER PT J AU Biggerstaff, TL Reynolds, CL Zheleva, T Lelis, A Habersat, D Haney, S Ryu, SH Agarwal, A Duscher, G AF Biggerstaff, T. L. Reynolds, C. L., Jr. Zheleva, T. Lelis, A. Habersat, D. Haney, S. Ryu, S. -H. Agarwal, A. Duscher, G. TI Relationship between 4H-SiC/SiO2 transition layer thickness and mobility SO APPLIED PHYSICS LETTERS LA English DT Article DE aluminium; annealing; crystal microstructure; electron energy loss spectra; interface states; MOSFET; semiconductor thin films; silicon compounds; surface chemistry; wide band gap semiconductors ID TRANSMISSION ELECTRON-MICROSCOPE; SILICON-CARBIDE; NITRIC-OXIDE; INTERFACE; SPECTROSCOPY; POLYTYPE AB The interfacial region between silicon carbide (SiC) and its native oxide contains a high density of interfacial traps, which is considered a major problem leading to a lower mobility that has hindered SiC metal oxide semiconductor field effect transistors from reaching their theoretical expectations. We investigate the microstructure and chemistry of the 4H-SiC/SiO2 interface due to variations in nitric oxide annealing and aluminum implantation using Z-contrast imaging and electron energy loss spectroscopy. A transition layer with a carbon to silicon ratio greater than 1 is consistently observed on the SiC side of the interface in each of these samples, and the width of this transition layer is found to be inversely related to the effective channel mobility measured on fabricated devices. C1 [Biggerstaff, T. L.; Reynolds, C. L., Jr.; Duscher, G.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Zheleva, T.; Lelis, A.; Habersat, D.] USA, Res Lab, Adelphi, MD 20783 USA. [Haney, S.; Ryu, S. -H.; Agarwal, A.] Cree Inc, Durham, NC 27703 USA. RP Biggerstaff, TL (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. EM trinity.biggerstaff@gmail.com RI Duscher, Gerd/G-1730-2014 OI Duscher, Gerd/0000-0002-2039-548X NR 22 TC 49 Z9 50 U1 3 U2 23 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUL 20 PY 2009 VL 95 IS 3 AR 032108 DI 10.1063/1.3144272 PG 3 WC Physics, Applied SC Physics GA 475ZA UT WOS:000268405300035 ER PT J AU Shen, H Wraback, M Zhong, H Tyagi, A DenBaars, SP Nakamura, S Speck, JS AF Shen, H. Wraback, M. Zhong, H. Tyagi, A. DenBaars, S. P. Nakamura, S. Speck, J. S. TI Unambiguous evidence of the existence of polarization field crossover in a semipolar InGaN/GaN single quantum well SO APPLIED PHYSICS LETTERS LA English DT Article DE electroreflectance; gallium compounds; III-V semiconductors; indium compounds; light polarisation; semiconductor growth; semiconductor quantum wells ID PIEZOELECTRIC FIELD; MODULATION SPECTROSCOPY; ELECTROREFLECTANCE; HETEROSTRUCTURES; SEMICONDUCTORS; DIODES AB We present an electroreflectance study of the piezoelectric field in a semipolar (10 (11) over bar) oriented In(0.15)Ga(0.85)N quantum well (QW). The flatband condition is precisely determined by examining the zero-crossing of the electroreflectance signal. The polarization field determined by the flatband condition is 840 +/- 150 kV/cm, in the direction opposite to the built-in field. The corresponding polarization charge at the heterointerface is 0.008 +/- 0.002 C/m(2). Our experimental result indicates that in the semipolar InGaN/GaN QW there is a crossover angle between the C-axis and the growth direction where the polarization field vanishes. C1 [Shen, H.; Wraback, M.] USA, Res Lab, Adelphi, MD 20783 USA. [Zhong, H.; Tyagi, A.; DenBaars, S. P.; Nakamura, S.; Speck, J. S.] Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA. [Zhong, H.; Tyagi, A.; DenBaars, S. P.; Nakamura, S.; Speck, J. S.] Univ Calif Santa Barbara, Dept Elect & Comp Engn, Santa Barbara, CA 93106 USA. RP Shen, H (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM pshen@arl.army.mil RI Speck, James/H-5646-2011 FU Solid State Lighting and Energy Center (SSLEC); NSF [DMR05-20415] FX The work at UCSB was supported by the Solid State Lighting and Energy Center (SSLEC). This work made use of the NSF MRSEC Facilities at UCSB (NSF Grant No. DMR05-20415). NR 20 TC 39 Z9 39 U1 1 U2 9 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUL 20 PY 2009 VL 95 IS 3 AR 033503 DI 10.1063/1.3167809 PG 3 WC Physics, Applied SC Physics GA 475ZA UT WOS:000268405300081 ER PT J AU Zhu, YT Wu, XL Liao, XZ Narayan, J Mathaudhu, SN Kecskes, LJ AF Zhu, Y. T. Wu, X. L. Liao, X. Z. Narayan, J. Mathaudhu, S. N. Kecskes, L. J. TI Twinning partial multiplication at grain boundary in nanocrystalline fcc metals SO APPLIED PHYSICS LETTERS LA English DT Article DE deformation; dislocations; grain growth; grain size; nanostructured materials; twin boundaries ID MOLECULAR-DYNAMICS SIMULATION; FORMATION MECHANISM; DEFORMATION-MECHANISM; AL; TWINS; ALUMINUM; COPPER; SLIP AB Most deformation twins in nanocrystalline face-centered cubic (fcc) metals have been observed to form from grain boundaries. The growth of such twins requires the emission of Shockley partials from the grain boundary on successive slip planes. However, it is statistically improbable for a partial to exist on every slip plane. Here we propose a dislocation reaction and cross-slip mechanism on the grain boundary that would supply a partial on every successive slip plane for twin growth. This mechanism can also produce a twin with macrostrain smaller than that caused by a conventional twin. C1 [Zhu, Y. T.; Narayan, J.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Mathaudhu, S. N.; Kecskes, L. J.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Liao, X. Z.] Univ Sydney, Sch Aerosp Mech & Mechatron Engn, Sydney, NSW 2006, Australia. [Wu, X. L.] Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100080, Peoples R China. RP Zhu, YT (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. EM ytzhu@ncsu.edu RI Zhu, Yuntian/B-3021-2008; Liao, Xiaozhou/B-3168-2009; Mathaudhu, Suveen/B-4192-2009; Narayan, Jagdish/D-1874-2009 OI Zhu, Yuntian/0000-0002-5961-7422; Liao, Xiaozhou/0000-0001-8565-1758; NR 25 TC 62 Z9 64 U1 4 U2 60 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUL 20 PY 2009 VL 95 IS 3 AR 031909 DI 10.1063/1.3187539 PG 3 WC Physics, Applied SC Physics GA 475ZA UT WOS:000268405300022 ER PT J AU May, L Chretien, JP Pavlin, JA AF May, Larissa Chretien, Jean-Paul Pavlin, Julie A. TI Beyond traditional surveillance: applying syndromic surveillance to developing settings - opportunities and challenges SO BMC PUBLIC HEALTH LA English DT Review ID VIRUS EPIDEMICS; CLIMATE; DISEASE; PREDICTION; OUTBREAK; SYSTEMS; FEVER AB Background: All countries need effective disease surveillance systems for early detection of outbreaks. The revised International Health Regulations [IHR], which entered into force for all 194 World Health Organization member states in 2007, have expanded traditional infectious disease notification to include surveillance for public health events of potential international importance, even if the causative agent is not yet known. However, there are no clearly established guidelines for how countries should conduct this surveillance, which types of emerging disease syndromes should be reported, nor any means for enforcement. Discussion: The commonly established concept of syndromic surveillance in developed regions encompasses the use of pre-diagnostic information in a near real time fashion for further investigation for public health action. Syndromic surveillance is widely used in North America and Europe, and is typically thought of as a highly complex, technology driven automated tool for early detection of outbreaks. Nonetheless, low technology applications of syndromic surveillance are being used worldwide to augment traditional surveillance. Summary: In this paper, we review examples of these novel applications in the detection of vector-borne diseases, foodborne illness, and sexually transmitted infections. We hope to demonstrate that syndromic surveillance in its basic version is a feasible and effective tool for surveillance in developing countries and may facilitate compliance with the new IHR guidelines. C1 [May, Larissa] George Washington Univ, Dept Emergency Med, Washington, DC 20037 USA. [Chretien, Jean-Paul] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD 20910 USA. [Chretien, Jean-Paul] Johns Hopkins Univ, Sch Med, Div Hlth Sci Informat, Baltimore, MD USA. [Pavlin, Julie A.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Pavlin, Julie A.] US Army Med Component, Bangkok 10400, Thailand. RP May, L (reprint author), George Washington Univ, Dept Emergency Med, 2150 Penn Ave NW Suite 2B, Washington, DC 20037 USA. EM larissa.may@gmail.com; jpchretien@gmail.com; julie.pavlin@afrims.org RI Valle, Ruben/A-7512-2013; OI Chretien, Jean-Paul/0000-0001-8143-6823 NR 56 TC 22 Z9 22 U1 0 U2 7 PU BIOMED CENTRAL LTD PI LONDON PA CURRENT SCIENCE GROUP, MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD JUL 16 PY 2009 VL 9 AR 242 DI 10.1186/1471-2458-9-242 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 480WG UT WOS:000268767100001 PM 19607669 ER PT J AU Houlahan, TJ Marsh, CP Park, SJ Masters, BC Eden, JG AF Houlahan, T. J. Marsh, C. P. Park, S. -J. Masters, B. C. Eden, J. G. TI Microcavity-enhanced electron emission from lead zirconate-titanate cathodes SO ELECTRONICS LETTERS LA English DT Article ID FERROELECTRICS AB Enhanced electron emission has been observed from lead zirconate-titanate (PZT) surfaces into which arrays of microcavities have been fabricated by nanopowder blasting. Arrays of microcavities, each having an elliptical cross-sectional geometry with major and minor axis lengths of 800 and 600 mm, respectively, and depths adjustable from 40 to 300 mm, exhibit a pronounced dependence of the emitter electron current on microcavity depth. For electric field strengths at the emitter surface of similar to 5-12 V/mu m, the RMS current density generated by an array of 250 mu m-deep microcavities with a packing density of 214+/-2 cm(-2) ranges from similar to 3 mA cm(-2) to beyond 8 mA cm(-2), or more than a factor of five larger than that produced from a planar PZT surface. C1 [Houlahan, T. J.; Marsh, C. P.; Masters, B. C.] USA, Corps Engineers, Engn Res & Dev Ctr, Champaign, IL 61822 USA. [Park, S. -J.; Eden, J. G.] Univ Illinois, Dept Elect & Comp Engn, Lab Opt Phys & Engn, Urbana, IL 61801 USA. [Marsh, C. P.; Masters, B. C.] Univ Illinois, Dept Nucl Plasma & Radiol Engn, Urbana, IL 61801 USA. RP Houlahan, TJ (reprint author), USA, Corps Engineers, Engn Res & Dev Ctr, Champaign, IL 61822 USA. EM sjinpark@uiuc.edu FU U.S. Army [W9132T-07-2-0006]; US Air Force Office of Scientific Research FX The technical assistance of V. Brown and the support of the U.S. Army (Headquarters, US Army Corps of Engineers) under RDTE Program AT23, grant no. W9132T-07-2-0006, and the US Air Force Office of Scientific Research is gratefully acknowledged. NR 8 TC 0 Z9 0 U1 0 U2 3 PU INST ENGINEERING TECHNOLOGY-IET PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 0013-5194 J9 ELECTRON LETT JI Electron. Lett. PD JUL 16 PY 2009 VL 45 IS 15 BP 778 EP 779 DI 10.1049/el.2009.0386 PG 2 WC Engineering, Electrical & Electronic SC Engineering GA 474HS UT WOS:000268274000008 ER PT J AU Dent, AE Chelimo, K Sumba, PO Spring, MD Crabb, BS Moormann, AM Tisch, DJ Kazura, JW AF Dent, Arlene E. Chelimo, Kiprotich Sumba, Peter O. Spring, Michele D. Crabb, Brendan S. Moormann, Ann M. Tisch, Daniel J. Kazura, James W. TI Temporal stability of naturally acquired immunity to Merozoite Surface Protein-1 in Kenyan Adults SO MALARIA JOURNAL LA English DT Article ID MALARIA-HOLOENDEMIC AREA; BLOOD-STAGE ANTIGENS; INVASION-INHIBITORY ANTIBODIES; APICAL MEMBRANE ANTIGEN-1; PLASMODIUM-FALCIPARUM; INTERFERON-GAMMA; IMMUNOGENICITY TRIAL; CLINICAL MALARIA; WESTERN KENYA; RESPONSES AB Background: Naturally acquired immunity to blood-stage Plasmodium falciparum infection develops with age and after repeated infections. In order to identify immune surrogates that can inform vaccine trials conducted in malaria endemic populations and to better understand the basis of naturally acquired immunity it is important to appreciate the temporal stability of cellular and humoral immune responses to malaria antigens. Methods: Blood samples from 16 adults living in a malaria holoendemic region of western Kenya were obtained at six time points over the course of 9 months. T cell immunity to the 42 kDa C-terminal fragment of Merozoite Surface Protein-1 (MSP-142) was determined by IFN-gamma ELISPOT. Antibodies to the 42 kDa and 19 kDa C-terminal fragments of MSP-1 were determined by serology and by functional assays that measure MSP-119 invasion inhibition antibodies (IIA) to the E-TSR (3D7) allele and growth inhibitory activity (GIA). The haplotype of MSP-119 alleles circulating in the population was determined by PCR. The kappa test of agreement was used to determine stability of immunity over the specified time intervals of 3 weeks, 6 weeks, 6 months, and 9 months. Results: MSP-1 IgG antibodies determined by serology were most consistent over time, followed by MSP-1 specific T cell IFN-gamma responses and GIA. MSP-1(19) IIA showed the least stability over time. However, the level of MSP-1(19) specific IIA correlated with relatively higher rainfall and higher prevalence of P. falciparum infection with the MSP-1(19) E-TSR haplotype. Conclusion: Variation in the stability of cellular and humoral immune responses to P. falciparum blood stage antigens needs to be considered when interpreting the significance of these measurements as immune endpoints in residents of malaria endemic regions. C1 [Dent, Arlene E.; Moormann, Ann M.; Tisch, Daniel J.; Kazura, James W.] Case Western Reserve Univ, Cleveland, OH 44106 USA. [Chelimo, Kiprotich; Sumba, Peter O.] Kenya Govt Med Res Ctr, Kisumu, Kenya. [Spring, Michele D.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Crabb, Brendan S.] Burnet Inst Med Res, Melbourne, Vic, Australia. RP Kazura, JW (reprint author), Case Western Reserve Univ, Cleveland, OH 44106 USA. EM arlene.dent@case.edu; chelimokip@yahoo.co.uk; odadakasumba@yahoo.com; michele.spring@amedd.army.mil; crabb@burnet.edu.au; ann.moormann@case.edu; daniel.tisch@case.edu; james.kazura@case.edu RI Spring, Michele/B-3564-2011; Crabb, Brendan/F-5287-2013 FU NIH [R01 AI43906]; FIC [1D43TW006576]; BWF CAMS [1006818] FX This work was performed with the permission of the Director of the Kenya Medical Research Institute. The authors thank the study participants for their contribution and Fredrick Opinya, John Ogone and John Oyombe for study participant recruitment and coordinating longitudinal field activities. The authors thank Rhonda J. Kimmel for laboratory assistance. This work was supported by NIH R01 AI43906 (JWK) and FIC 1D43TW006576 (KC and POS). AED is supported by BWF CAMS 1006818. NR 44 TC 17 Z9 17 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA CURRENT SCIENCE GROUP, MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD JUL 16 PY 2009 VL 8 AR 162 DI 10.1186/1475-2875-8-162 PG 10 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 486BO UT WOS:000269170700001 PM 19607717 ER PT J AU Lee, MS Bondugula, R Desai, V Zavaljevski, N Yeh, IC Wallqvist, A Reifman, J AF Lee, Michael S. Bondugula, Rajkumar Desai, Valmik Zavaljevski, Nela Yeh, In-Chul Wallqvist, Anders Reifman, Jaques TI PSPP: A Protein Structure Prediction Pipeline for Computing Clusters SO PLOS ONE LA English DT Article AB Background: Protein structures are critical for understanding the mechanisms of biological systems and, subsequently, for drug and vaccine design. Unfortunately, protein sequence data exceed structural data by a factor of more than 200 to 1. This gap can be partially filled by using computational protein structure prediction. While structure prediction Web servers are a notable option, they often restrict the number of sequence queries and/or provide a limited set of prediction methodologies. Therefore, we present a standalone protein structure prediction software package suitable for high-throughput structural genomic applications that performs all three classes of prediction methodologies: comparative modeling, fold recognition, and ab initio. This software can be deployed on a user's own high-performance computing cluster. Methodology/Principal Findings: The pipeline consists of a Perl core that integrates more than 20 individual software packages and databases, most of which are freely available from other research laboratories. The query protein sequences are first divided into domains either by domain boundary recognition or Bayesian statistics. The structures of the individual domains are then predicted using template-based modeling or ab initio modeling. The predicted models are scored with a statistical potential and an all-atom force field. The top-scoring ab initio models are annotated by structural comparison against the Structural Classification of Proteins (SCOP) fold database. Furthermore, secondary structure, solvent accessibility, transmembrane helices, and structural disorder are predicted. The results are generated in text, tab-delimited, and hypertext markup language (HTML) formats. So far, the pipeline has been used to study viral and bacterial proteomes. Conclusions: The standalone pipeline that we introduce here, unlike protein structure prediction Web servers, allows users to devote their own computing assets to process a potentially unlimited number of queries as well as perform resource-intensive ab initio structure prediction. RP Lee, MS (reprint author), USA, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD USA. EM jaques.reifman@us.army.mil OI wallqvist, anders/0000-0002-9775-7469 NR 51 TC 8 Z9 8 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUL 16 PY 2009 VL 4 IS 7 AR e6254 DI 10.1371/journal.pone.0006254 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 471DU UT WOS:000268036000010 PM 19606223 ER PT J AU Gudmundsdotter, L Nilsson, C Brave, A Hejdeman, B Earl, P Moss, B Robb, M Cox, J Michael, N Marovich, M Biberfeld, G Sandstrom, E Wahren, B AF Gudmundsdotter, Lindvi Nilsson, Charlotta Brave, Andreas Hejdeman, Bo Earl, Patricia Moss, Bernard Robb, Merlin Cox, Josephine Michael, Nelson Marovich, Mary Biberfeld, Gunnel Sandstrom, Eric Wahren, Britta TI Recombinant Modified Vaccinia Ankara (MVA) effectively boosts DNA-primed HIV-specific immune responses in humans despite pre-existing vaccinia immunity SO VACCINE LA English DT Article DE HIV-1 vaccine; Modified Vaccinia virus Ankara (MVA); Pre-existing immunity ID CD8(+) T-CELL; VIRUS ANKARA; VACCINATION; VECTOR; IMMUNOGENICITY; IMMUNIZATION; SMALLPOX; PROTEIN; SAFETY; GLYCOPROTEIN AB The presence of vector-specific immune responses may hamper the induction of responses to a foreign antigen encoded by the vector. We evaluated the impact of pre-existing immunity to vaccinia virus on the induction of HIV-specific responses after immunization of healthy volunteers with a HIV-1 DNA prime-MVA boost vaccine. Following three priming immunizations with HIV-1 DNA plasmids, the volunteers were boosted with a single injection of recombinant MVA encoding HIV-1 proteins. Pre-existing immunity to vaccinia virus did not reduce the proportion of individuals who responded to HIV-1, but: did lower the magnitude of responses. Our results suggest that vaccinia-based vectors can be used to efficiently induce immune responses to vectored HIV-1 antigens, even in individuals with pre-existing immunity to vaccinia virus. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Gudmundsdotter, Lindvi; Nilsson, Charlotta; Brave, Andreas; Biberfeld, Gunnel; Wahren, Britta] Swedish Inst Infect Dis Control, Stockholm, Sweden. [Gudmundsdotter, Lindvi; Nilsson, Charlotta; Brave, Andreas; Biberfeld, Gunnel; Wahren, Britta] Karolinska Inst, Stockholm, Sweden. [Hejdeman, Bo; Sandstrom, Eric] Soder Sjukhuset, Stockholm, Sweden. [Earl, Patricia; Moss, Bernard] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA. [Robb, Merlin; Michael, Nelson; Marovich, Mary] Walter Reed Army Inst Res, Dept Retroviral, Rockville, MD USA. [Cox, Josephine] IAVI, New York, NY USA. RP Gudmundsdotter, L (reprint author), Swedish Inst Infect Dis Control, Stockholm, Sweden. EM L.gudmundsdotter@smi.se FU European Union [INCO-DEV A4 ICFP501A4PR03, AVIP 503487]; Swedish International Development Cooperation Agency (Sida); Department of Research Cooperation (SAREC) [SWE-2004-120, HIV2004-000809, 2004:813]; Swedish Research Council (VetenskapsrAdet) [K2004-16x-07743-19]; Lakare mot AIDS Forskningsfond [04-050301, 01-051101]; Division of Intramural Research; National Institute of Allergy and Infectious Diseases; National Institutes of Health; US Military HIV Research Program; Walter Reed Army Institute of Research FX This study was supported by the European Union (INCO-DEV A4 ICFP501A4PR03, AVIP 503487); Swedish International Development Cooperation Agency (Sida); Department of Research Cooperation (SAREC) (SWE-2004-120, HIV2004-000809, 2004:813); Swedish Research Council (VetenskapsrAdet, K2004-16x-07743-19); Lakare mot AIDS Forskningsfond (04-050301 and 01-051101). Construction of the HIV-1 modified vaccinia virus Ankara was supported by the Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health and the US Military HIV Research Program. The production costs were funded by the US Military HIV Research Program, Walter Reed Army Institute of Research. NR 33 TC 41 Z9 41 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JUL 16 PY 2009 VL 27 IS 33 BP 4468 EP 4474 DI 10.1016/j.vaccine.2009.05.018 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 473OR UT WOS:000268217600013 PM 19450644 ER PT J AU Webb, RP Smith, TJ Wright, P Brown, J Smith, LA AF Webb, Robert P. Smith, Theresa J. Wright, Patrick Brown, Jennifer Smith, Leonard A. TI Production of catalytically inactive BoNT/A1 holoprotein and comparison with BoNT/A1 subunit vaccines against toxin subtypes A1, A2, and A3 SO VACCINE LA English DT Article DE Clostridium botulinum; BoNT; Vaccine; Botulism ID BOTULINUM NEUROTOXIN-A; CLOSTRIDIAL NEUROTOXINS; PICHIA-PASTORIS; BINDING DOMAIN; PROTEIN-RECEPTOR; SEROTYPE-E; PURIFICATION; SEQUENCE; EFFICACY; CANDIDATE AB A recombinant, catalytically inactive Clostridium botulinum neurotoxin A1 holoprotein (ciBoNT/A1 HP) was constructed by introducing amino acid substitutions H223A, E224A, and H227A in the active site to ablate proteolytic activity. ciBoNT/A1 HP was produced in the yeast Pichia pastoris and the purified product was evaluated as a vaccine candidate by comparison against recombinant BoNT/A1 LC, LC-belt, LC-H(n), and H(c) antigens and a LC-H(n) + H(c) combination in mouse potency and efficacy bioassays when challenged with BoNT/A subtypes /A1, /A2, and /A3. A single dose of ciBoNT/A1 HP provided equivalent or greater protective immunity, not only against the homologous toxin, but also against two distinct toxin subtypes with significant amino acid divergence. Only the LC-H(n) + H(c) combination provided comparable protection against/A1; however, it was less effective against subtypes /A2 and /A3. Differences in protective immunity diminished after multiple vaccinations with either ciBoNT/A1 HP or BoNT/A1 H(c), and the survival rates were more comparable at the toxin levels used to challenge. Published by Elsevier Ltd. C1 [Webb, Robert P.; Smith, Theresa J.; Wright, Patrick; Brown, Jennifer; Smith, Leonard A.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Smith, LA (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM Leonard.smith@amedd.army.mil FU joint Science and Technology Office for Chemical-Biological Defense FX The research described herein was sponsored by the joint Science and Technology Office for Chemical-Biological Defense. The authors thank Dr. Virginia Roxas-Duncan and Ms. Vanessa Eccard for conducting the enzymatic assay on ciBoNT/A1 HP. We also thank Ms. Sarah Norris for providing statistical analysis of the data. The views and opinions expressed in this paper are those of the author(s) and do not reflect official policy or position of the Department of the Army, Department of Defense, or the U.S. Government. NR 39 TC 30 Z9 33 U1 1 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JUL 16 PY 2009 VL 27 IS 33 BP 4490 EP 4497 DI 10.1016/j.vaccine.2009.05.030 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 473OR UT WOS:000268217600016 PM 19450643 ER PT J AU Steers, NJ Peachman, KK McClain, SR Alving, CR Rao, M AF Steers, Nicholas J. Peachman, Kristina K. McClain, Sasha R. Alving, Carl R. Rao, Mangala TI Human Immunodeficiency Virus Type 1 Gag p24 Alters the Composition of Immunoproteasomes and Affects Antigen Presentation SO JOURNAL OF VIROLOGY LA English DT Article ID MHC CLASS-I; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; T-CELL RESPONSES; COMPLEX CLASS-I; PROTEASOME ACTIVATOR PA28; DENDRITIC CELLS; QUANTITATIVE-ANALYSIS; FUNCTIONAL DIVERSITY; PROTEIN-DEGRADATION; EXOGENOUS ANTIGENS AB Proteasomes are the major source of proteases responsible for the generation of peptides bound to major histocompatibility complex class I molecules. Antigens, adjuvants, and cytokines can modulate the composition and enzymatic activity of proteasomes and thus alter the epitopes generated. In the present study, we examined the effect of human immunodeficiency virus type 1 (HIV-1) p24 on proteasomes from a dendritic cell line (JAWS II), from a macrophage cell line (C2.3), and from murine primary bone marrow-derived macrophages and dendritic cells. HIV-1 p24 downregulated PA28 beta and the beta 2i subunit of the immunoproteasome complex in JAWS II cells but did not decrease the immunoproteasome subunits in macrophages, whereas in primary dendritic cells, PA28 alpha, beta 2i, and beta 5i were downregulated. Exposure of JAWS II cells and primary dendritic cells to HIV-1 p24 for 90 min significantly decreased the presentation of ovalbumin to a SIINFEKL-specific CD8(+) T-cell hybridoma. The decrease in antigen presentation and the downmodulation of the immunoproteasome subunits in JAWS II cells and primary dendritic cells could be overcome by pretreating the cells with gamma interferon for 6 h or by exposing the cells to HIV-1 p24 encapsulated in liposomes containing lipid A. These results suggest that early antigen processing kinetics could influence the immunogenicity of CD8(+) T-cell epitopes generated. C1 [Alving, Carl R.; Rao, Mangala] USMHRP, Div Retrovirol, Walter Reed Army Inst Res, Rockville, MD 20850 USA. [Steers, Nicholas J.; Peachman, Kristina K.; McClain, Sasha R.] Henry M Jackson Fdn, Rockville, MD 20850 USA. RP Rao, M (reprint author), USMHRP, Div Retrovirol, Walter Reed Army Inst Res, 1600 E Gude Dr, Rockville, MD 20850 USA. EM mrao@hivresearch.org FU In-House Laboratory-Independent Research Award FX We thank Elaine B. Morrison for helping with the animal work. The views expressed in this article are those of the authors and do not reflect the official policy of the Department of the Army, the Department of Defense, or the U.S. government. NR 72 TC 11 Z9 11 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD JUL 15 PY 2009 VL 83 IS 14 BP 7049 EP 7061 DI 10.1128/JVI.00327-09 PG 13 WC Virology SC Virology GA 462LO UT WOS:000267354300009 PM 19403671 ER PT J AU Geisbert, TW Geisbert, JB Leung, A Daddario-DiCaprio, KM Hensley, LE Grolla, A Feldmann, H AF Geisbert, Thomas W. Geisbert, Joan B. Leung, Anders Daddario-DiCaprio, Kathleen M. Hensley, Lisa E. Grolla, Allen Feldmann, Heinz TI Single-Injection Vaccine Protects Nonhuman Primates against Infection with Marburg Virus and Three Species of Ebola Virus SO JOURNAL OF VIROLOGY LA English DT Article ID ATTENUATED RECOMBINANT VACCINE; HEMORRHAGIC-FEVER; POSTEXPOSURE PROTECTION; ADENOVIRUS VECTORS; CHALLENGE; OUTBREAK; CHILDREN; STRAINS; DISEASE; ANGOLA AB The filoviruses Marburg virus and Ebola virus cause severe hemorrhagic fever with high mortality in humans and nonhuman primates. Among the most promising filovirus vaccines under development is a system based on recombinant vesicular stomatitis virus (VSV) that expresses a single filovirus glycoprotein (GP) in place of the VSV glycoprotein (G). Here, we performed a proof-of-concept study in order to determine the potential of having one single-injection vaccine capable of protecting nonhuman primates against Sudan ebolavirus (SEBOV), Zaire ebolavirus (ZEBOV), Cote d'Ivoire ebolavirus (CIEBOV), and Marburgvirus (MARV). In this study, 11 cynomolgus monkeys were vaccinated with a blended vaccine consisting of equal parts of the vaccine vectors VSV Delta G/SEBOVGP, VSV Delta G/ZEBOVGP, and VSV Delta G/MARVGP. Four weeks later, three of these animals were challenged with MARV, three with CIEBOV, three with ZEBOV, and two with SEBOV. Three control animals were vaccinated with VSV vectors encoding a nonfilovirus GP and challenged with SEBOV, ZEBOV, and MARV, respectively, and five unvaccinated control animals were challenged with CIEBOV. Importantly, none of the macaques vaccinated with the blended vaccine succumbed to a filovirus challenge. As expected, an experimental control animal vaccinated with VSV Delta G/ZEBOVGP and challenged with SEBOV succumbed, as did the positive controls challenged with SEBOV, ZEBOV, and MARV, respectively. All five control animals challenged with CIEBOV became severely ill, and three of the animals succumbed on days 12, 12, and 14, respectively. The two animals that survived CIEBOV infection were protected from subsequent challenge with either SEBOV or ZEBOV, suggesting that immunity to CIEBOV may be protective against other species of Ebola virus. In conclusion, we developed an immunization scheme based on a single-injection vaccine that protects nonhuman primates against lethal challenge with representative strains of all human pathogenic filovirus species. C1 [Geisbert, Thomas W.] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA. [Geisbert, Thomas W.; Geisbert, Joan B.; Daddario-DiCaprio, Kathleen M.] Boston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA. [Geisbert, Thomas W.] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA. [Geisbert, Thomas W.; Daddario-DiCaprio, Kathleen M.] Uniformed Serv Univ Hlth Sci, Dept Pathol, Bethesda, MD 20814 USA. [Geisbert, Thomas W.; Geisbert, Joan B.; Daddario-DiCaprio, Kathleen M.; Hensley, Lisa E.] USA, Div Virol, Med Res Inst Infect Dis, Ft Detrick, MD USA. [Leung, Anders; Grolla, Allen; Feldmann, Heinz] Publ Hlth Agcy Canada, Special Pathogens Program, Natl Microbiol Lab, Winnipeg, MB, Canada. [Feldmann, Heinz] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB, Canada. [Feldmann, Heinz] NIAID, Virol Lab, Div Intramural Res, NIH, Hamilton, MT USA. RP Geisbert, TW (reprint author), Boston Univ, Sch Med, Dept Microbiol, 72 E Concord St,R514, Boston, MA 02118 USA. EM geisbert@bu.edu FU Defense Threat Reduction Agency [04-4-7J-012]; Canadian Institutes of Health Research [MOP-39321] FX Work on filoviruses at USAMRIID was funded by the Defense Threat Reduction Agency (project number 04-4-7J-012). Work on filoviruses at the NML was supported by PHAC and through a grant awarded to H. F. from the Canadian Institutes of Health Research (MOP-39321). NR 37 TC 110 Z9 116 U1 0 U2 20 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD JUL 15 PY 2009 VL 83 IS 14 BP 7296 EP 7304 DI 10.1128/JVI.00561-09 PG 9 WC Virology SC Virology GA 462LO UT WOS:000267354300032 PM 19386702 ER PT J AU Simek, MD Rida, W Priddy, FH Pung, P Carrow, E Laufer, DS Lehrman, JK Boaz, M Tarragona-Fiol, T Miiro, G Birungi, J Pozniak, A McPhee, DA Manigart, O Karita, E Inwoley, A Jaoko, W DeHovitz, J Bekker, LG Pitisuttithum, P Paris, R Walker, LM Poignard, P Wrin, T Fast, PE Burton, DR Koff, WC AF Simek, Melissa D. Rida, Wasima Priddy, Frances H. Pung, Pham Carrow, Emily Laufer, Dagna S. Lehrman, Jennifer K. Boaz, Mark Tarragona-Fiol, Tony Miiro, George Birungi, Josephine Pozniak, Anton McPhee, Dale A. Manigart, Olivier Karita, Etienne Inwoley, Andre Jaoko, Walter DeHovitz, Jack Bekker, Linda-Gail Pitisuttithum, Punnee Paris, Robert Walker, Laura M. Poignard, Pascal Wrin, Terri Fast, Patricia E. Burton, Dennis R. Koff, Wayne C. TI Human Immunodeficiency Virus Type 1 Elite Neutralizers: Individuals with Broad and Potent Neutralizing Activity Identified by Using a High-Throughput Neutralization Assay together with an Analytical Selection Algorithm SO JOURNAL OF VIROLOGY LA English DT Article ID HUMAN MONOCLONAL-ANTIBODIES; CROSS-CLADE NEUTRALIZATION; INFECTIOUS-DISEASES; H5N1 VACCINE; HIV-1 GP120; COMBINATORIAL LIBRARIES; PASSIVE-IMMUNIZATION; CLINICAL-TRIAL; CHALLENGE; RESPONSES AB The development of a rapid and efficient system to identify human immunodeficiency virus type 1 (HIV-1)infected individuals with broad and potent HIV-1-specific neutralizing antibody responses is an important step toward the discovery of critical neutralization targets for rational AIDS vaccine design. In this study, samples from HIV-1-infected volunteers from diverse epidemiological regions were screened for neutralization responses using pseudovirus panels composed of clades A, B, C, and D and circulating recombinant forms (CRFs). Initially, 463 serum and plasma samples from Australia, Rwanda, Uganda, the United Kingdom, and Zambia were screened to explore neutralization patterns and selection ranking algorithms. Samples were identified that neutralized representative isolates from at least four clade/CRF groups with titers above prespecified thresholds and ranked based on a weighted average of their log-transformed neutralization titers. Linear regression methods selected a five-pseudovirus subset, representing clades A, B, and C and one CRF01_AE, that could identify top-ranking samples with 50% inhibitory concentration (IC(50)) neutralization titers of >= 100 to multiple isolates within at least four clade groups. This reduced panel was then used to screen 1,234 new samples from the Ivory Coast, Kenya, South Africa, Thailand, and the United States, and 1% were identified as elite neutralizers. Elite activity is defined as the ability to neutralize, on average, more than one pseudovirus at an IC(50) titer of 300 within a clade group and across at least four clade groups. These elite neutralizers provide promising starting material for the isolation of broadly neutralizing monoclonal antibodies to assist in HIV-1 vaccine design. C1 [Simek, Melissa D.; Priddy, Frances H.; Laufer, Dagna S.; Lehrman, Jennifer K.; Boaz, Mark; Fast, Patricia E.; Koff, Wayne C.] Int AIDS Vaccine Initiat, New York, NY 10028 USA. [Pung, Pham; Wrin, Terri] Monogram Biosci Inc, San Francisco, CA USA. [Walker, Laura M.; Poignard, Pascal; Burton, Dennis R.] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA. [Walker, Laura M.; Poignard, Pascal; Burton, Dennis R.] Scripps Res Inst, Int AIDS Vaccine Initiat, Neutralizing Antibody Ctr, La Jolla, CA 92037 USA. [Manigart, Olivier; Karita, Etienne] Emory Univ, Rwanda Zambia HIV Res Grp, Atlanta, GA 30322 USA. [Miiro, George] MRC, Uganda Virus Res Inst, Entebbe, Uganda. [Birungi, Josephine] Int AIDS Vaccine Initiat, Uganda Virus Res Inst, Entebbe, Uganda. [McPhee, Dale A.] Natl Ctr HIV1 Epidemiol & Clin Res, Natl Serol Reference Lab, Fitzroy, Vic, Australia. [Pozniak, Anton] St Stephens AIDS Trust, London, England. [Carrow, Emily] Adv BioAdjuvants LLC, Omaha, NE USA. [Inwoley, Andre] CeDReS, Diagnost Ctr & Res AIDS & Opportunist dis, Abidjan, Cote Ivoire. [Jaoko, Walter] Univ Nairobi, Kenya AIDS Vaccine Initiat, Nairobi, Kenya. [DeHovitz, Jack] Suny Downstate Med Ctr, Dept Prevent Med, Brooklyn, NY 11203 USA. [Bekker, Linda-Gail] Univ Cape Town, Desmond Tutu HIV1 Fdn, ZA-7925 Cape Town, South Africa. [Pitisuttithum, Punnee] Mahidol Univ, Dept Clin Trop Med, Clin Infect Dis Res Unit, Vaccine Trial Ctr, Bangkok 10700, Thailand. [Paris, Robert] Mahidol Univ, Dept Retrovirol, Armed Forces Res Inst Med Sci, Bangkok 10700, Thailand. [Tarragona-Fiol, Tony] Univ London Imperial Coll Sci Technol & Med, IAVI Core Lab, London, England. RP Simek, MD (reprint author), Int AIDS Vaccine Initiat, 110 William St,27th Floor, New York, NY 10028 USA. EM Msimek@iavi.org RI poignard, pascal/N-6678-2013 FU IAVI; Alfred P. Sloan Foundation; Bill and Melinda Gates Foundation; John D. Evans Foundation; New York Community Trust; James B. Pendleton Charitable Trust; Rockefeller Foundation; Starr Foundation; William and Flora Hewlett Foundation; government of Canada; government of Denmark; government of Ireland; government of The Netherlands; government of Norway; government of Sweden; government of United Kingdom; United States Agency for International Development (USAID); Basque Autonomous Government; European Union; The World Bank; Becton, Dickinson and Co.; Continental Airlines; Google Inc.; Merck and Co., Inc.; Pfizer Inc; Broadway Cares/Equity Fights AIDS; Until There's A Cure Foundation; The Haas Trusts FX This study was funded by the IAVI. IAVI's financial and in-kind supporters include the Alfred P. Sloan Foundation, the Bill and Melinda Gates Foundation, The John D. Evans Foundation, The New York Community Trust, the James B. Pendleton Charitable Trust, The Rockefeller Foundation, The Starr Foundation, The William and Flora Hewlett Foundation; the governments of Canada, Denmark, Ireland, The Netherlands, Norway, Sweden, and the United Kingdom, and the generous support of the American people through the United States Agency for International Development ( USAID), the Basque Autonomous Government as well as the European Union; multilateral organizations such as The World Bank; corporate donors including Becton, Dickinson and Co., Continental Airlines, Google Inc., Merck and Co., Inc., and Pfizer Inc; leading AIDS charities, such as Broadway Cares/Equity Fights AIDS and Until There's A Cure Foundation; other private donors, such as The Haas Trusts; and many generous individuals from around the world. NR 55 TC 294 Z9 297 U1 2 U2 22 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD JUL 15 PY 2009 VL 83 IS 14 BP 7337 EP 7348 DI 10.1128/JVI.00110-09 PG 12 WC Virology SC Virology GA 462LO UT WOS:000267354300035 PM 19439467 ER PT J AU Neff, RT Jindal, RM Yoo, DY Hurst, FP Agodoa, LY Abbott, KC AF Neff, Robert T. Jindal, Rahul M. Yoo, David Y. Hurst, Frank P. Agodoa, Lawrence Y. Abbott, Kevin C. TI Analysis of USRDS: Incidence and Risk Factors for Pneumocystis jiroveci Pneumonia SO TRANSPLANTATION LA English DT Article DE PCP; USRDS; Transplant infection ID ORGAN-TRANSPLANT RECIPIENTS; CARINII-PNEUMONIA; RENAL-TRANSPLANTATION; INFECTION; IMMUNOSUPPRESSION; PREVENTION; SIROLIMUS AB Background. To investigate the effect of modern immunosuppression on the incidence, risk factors, morbidity, and mortality of Pneumocystis pneumonia (PCP) in recipients of kidney transplants. Methods. We conducted a retrospective cohort study of 32,757 Medicare primary transplant recipients in the United States Renal Data System from January 1, 2000 through July 31, 2004. PCP infection was defined by Medicare claims using International Classification of Disease, 9th Revision codes. The incidence of PCP infections, graft loss, and death were measured. Results. There were a total of 142 cases (cumulative incidence 0.4%) of PCP after kidney transplantation during the study period. By using multivariate analysis with Cox regression, expanded criteria donor, donation after cardiac death, and earlier year of transplant were associated with development of PCP disease. Induction immunosuppression and acute rejections were not associated with risk for PCP infections. However, based on adjusted hazard ratio (AHR), maintenance immunosuppression regimens containing the combination of tacrolimus and sirolimus (AHR 3.60, confidence interval [CI] 2.03-6.39), Neoral and mycophenolate mofetil (AHR 2.09, CI 1.31-3.31), and sirolimus and mycophenolate mofetil (AHR 2.77, Cl 1.40-5.47), were associated with development of PCP. As a time dependent variable, PCP was associated with an increased risk of both graft loss and death. Conclusion. PCP infections are rare in the modern era of prophylaxis; however, these infections are a serious risk factor for graft loss and patient death, in particular, in patients who are on sirolimus as part of the immunosuppressive regimen. The median time to development of PCP after transplant was 0.80 +/- 0.95 years, suggesting a longer period of PCP prophylaxis. C1 [Neff, Robert T.; Jindal, Rahul M.; Hurst, Frank P.; Abbott, Kevin C.] Walter Reed Army Med Ctr, Organ Transplant Program, Washington, DC 20307 USA. [Neff, Robert T.; Jindal, Rahul M.; Hurst, Frank P.; Abbott, Kevin C.] Walter Reed Army Med Ctr, Nephrol SVC, Washington, DC 20307 USA. [Neff, Robert T.; Jindal, Rahul M.; Hurst, Frank P.; Abbott, Kevin C.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. [Jindal, Rahul M.] Brookdale Univ Hosp & Med Ctr, Dept Surg, Brooklyn, NY USA. [Yoo, David Y.] Walter Reed Army Med Ctr, Med Serv, Washington, DC 20307 USA. [Agodoa, Lawrence Y.] NIDDK, NIH, Bethesda, MD USA. RP Jindal, RM (reprint author), Walter Reed Army Med Ctr, Organ Transplant Program, 6630 Georgia Ave, Washington, DC 20307 USA. EM jindalr@msn.com OI Abbott, Kevin/0000-0003-2111-7112 NR 17 TC 43 Z9 45 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0041-1337 J9 TRANSPLANTATION JI Transplantation PD JUL 15 PY 2009 VL 88 IS 1 BP 135 EP 141 DI 10.1097/TP.0b013e3181aad256 PG 7 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA 468UJ UT WOS:000267848000022 PM 19584693 ER PT J AU Hayashi, T Kaneko, Y Yu, S Bae, E Stahl, CE Kawase, T van Loveren, H Sanberg, PR Borlongan, CV AF Hayashi, Takuro Kaneko, Yuji Yu, SeongJin Bae, EunKyung Stahl, Christine E. Kawase, Takeshi van Loveren, Harry Sanberg, Paul R. Borlongan, Cesar V. TI Quantitative analyses of matrix metalloproteinase activity after traumatic brain injury in adult rats SO BRAIN RESEARCH LA English DT Article DE Head injury; MMP-9; Cortex; Immunohistochemistry; Quantitative real-time PCR ID CONTROLLED CORTICAL IMPACT; EXPRESSION; MATRIX-METALLOPROTEINASE-9; SYNAPTOGENESIS; THERAPY; DEATH; MICE AB Recent laboratory evidence implicates matrix metalloproteinases (MMPs) as playing a pivotal role in ischemic and traumatic brain injuries (TBI). Here, quantitative real-time PCR analyses revealed that brains from TBI rats displayed significantly elevated MMP-9 expression at 24 h post-TBI, which remained upregulated at least until 48 h after injury. Immunohistochemical analyses similarly revealed significantly increased MMP-9 immunoreactivity at 24 and 48 h post-TBI. These results demonstrate that alterations in MMPs (i.e., MMP-9) commenced immediately after TBI, suggesting that treatment strategies designed to maintain MMP integrity should be initiated in the acute phase of injury. (C) 2009 Elsevier B.V. All rights reserved. C1 [Hayashi, Takuro; Kaneko, Yuji; Yu, SeongJin; Bae, EunKyung; van Loveren, Harry; Sanberg, Paul R.; Borlongan, Cesar V.] Univ S Florida, Dept Neurosurg, 12906 Bruce B Downs Blvd MDC78, Tampa, FL 33612 USA. [Stahl, Christine E.] Dwight D Eisenhower Army Med Ctr, Dept Internal Med, Ft Gordon, GA 30905 USA. [Kawase, Takeshi] Keio Univ, Dept Neurosurg, Shinjuku Ku, Tokyo 1608582, Japan. RP Borlongan, CV (reprint author), Univ S Florida, Dept Neurosurg, 12906 Bruce B Downs Blvd MDC78, Tampa, FL 33612 USA. EM cborlong@health.usf.edu OI Borlongan, Cesar/0000-0002-2966-9782 NR 25 TC 35 Z9 37 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-8993 EI 1872-6240 J9 BRAIN RES JI Brain Res. PD JUL 14 PY 2009 VL 1280 BP 172 EP 177 DI 10.1016/j.brainres.2009.05.040 PG 6 WC Neurosciences SC Neurosciences & Neurology GA 469OS UT WOS:000267909800020 PM 19464272 ER PT J AU Garcia-Reyero, N Kroll, KJ Liu, L Orlando, EF Watanabe, KH Sepulveda, MS Villeneuve, DL Perkins, EJ Ankley, GT Denslow, ND AF Garcia-Reyero, Natalia Kroll, Kevin J. Liu, Li Orlando, Edward F. Watanabe, Karen H. Sepulveda, Maria S. Villeneuve, Daniel L. Perkins, Edward J. Ankley, Gerald T. Denslow, Nancy D. TI Gene expression responses in male fathead minnows exposed to binary mixtures of an estrogen and antiestrogen SO BMC GENOMICS LA English DT Article ID MEDAKA ORYZIAS-LATIPES; ZEBRAFISH DANIO-RERIO; CROAKER MICROPOGONIAS-UNDULATUS; WASTE-WATER CONTAMINANTS; BREAST-CANCER CELLS; PIMEPHALES-PROMELAS; ATLANTIC CROAKER; LARGEMOUTH BASS; RECEPTOR-ALPHA; IN-VITRO AB Background: Aquatic organisms are continuously exposed to complex mixtures of chemicals, many of which can interfere with their endocrine system, resulting in impaired reproduction, development or survival, among others. In order to analyze the effects and mechanisms of action of estrogen/anti-estrogen mixtures, we exposed male fathead minnows (Pimephales promelas) for 48 hours via the water to 2, 5, 10, and 50 ng 17 alpha-ethinylestradiol (EE(2))/L, 100 ng ZM 189, 154/L (a potent antiestrogen known to block activity of estrogen receptors) or mixtures of 5 or 50 ng EE(2)/L with 100 ng ZM 189,154/L. We analyzed gene expression changes in the gonad, as well as hormone and vitellogenin plasma levels. Results: Steroidogenesis was down-regulated by EE2 as reflected by the reduced plasma levels of testosterone in the exposed fish and down-regulation of genes in the steroidogenic pathway. Microarray analysis of testis of fathead minnows treated with 5 ng EE(2)/L or with the mixture of 5 ng EE(2)/L and 100 ng ZM 189,154/L indicated that some of the genes whose expression was changed by EE(2) were blocked by ZM 189,154, while others were either not blocked or enhanced by the mixture, generating two distinct expression patterns. Gene ontology and pathway analysis programs were used to determine categories of genes for each expression pattern. Conclusion: Our results suggest that response to estrogens occurs via multiple mechanisms, including canonical binding to soluble estrogen receptors, membrane estrogen receptors, and other mechanisms that are not blocked by pure antiestrogens. C1 [Garcia-Reyero, Natalia; Kroll, Kevin J.; Denslow, Nancy D.] Univ Florida, Dept Physiol Sci, Gainesville, FL 32611 USA. [Garcia-Reyero, Natalia; Kroll, Kevin J.; Denslow, Nancy D.] Univ Florida, Ctr Environm & Human Toxicol, Gainesville, FL 32611 USA. [Liu, Li] Univ Florida, ICBR, Gainesville, FL 32611 USA. [Orlando, Edward F.] Univ Maryland, Dept Anim & Avian Sci, College Pk, MD 20742 USA. [Watanabe, Karen H.] Oregon Hlth & Sci Univ, Div Environm & Biomol Syst, Beaverton, OR 97006 USA. [Sepulveda, Maria S.] Purdue Univ, Dept Forestry & Nat Resources, W Lafayette, IN 47907 USA. [Villeneuve, Daniel L.; Ankley, Gerald T.] US EPA, ORD, NHEERL, MED, Duluth, MN 55804 USA. [Perkins, Edward J.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Denslow, ND (reprint author), Univ Florida, Dept Physiol Sci, Gainesville, FL 32611 USA. EM natalia@ccmsi.us; krollk@ufl.edu; liliu@biotech.ufl.edu; eorlando@umd.edu; watanabe@ebs.ogi.edu; mssepulv@purdue.edu; Villeneuve.Dan@epamail.epa.gov; Edward.J.Perkins@erdc.usace.army.mil; Ankley.Gerald@epamail.epa.gov; ndenslow@ufl.edu RI Sepulveda, Maria/P-3598-2014 FU Environmental Protection Agency STAR [R831848]; Spanish Ministry of Sciences and Technology [EX-2004-0986]; European Union FX This work was supported by the Environmental Protection Agency STAR grant, (R831848) to ND, MS, EO and KW, and by a fellowship from the Spanish Ministry of Sciences and Technology (EX-2004-0986) co-funded by the European Union to NGR. We wish to thank Dr. Thomas Hutchinson, (formerly of AstraZeneca) for the generous gift of ZM189,154. The research described in this article does not necessarily reflect the views of the EPA and no official endorsement should be inferred. NDD holds equity in EcoArray, Inc., a company commercializing the microarray technology used in this study. NR 86 TC 42 Z9 43 U1 0 U2 25 PU BIOMED CENTRAL LTD PI LONDON PA CURRENT SCIENCE GROUP, MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD JUL 13 PY 2009 VL 10 AR 308 DI 10.1186/1471-2164-10-308 PG 17 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA 480RX UT WOS:000268755600001 PM 19594897 ER PT J AU Knapik, JJ Marin, RE Grier, TL Jones, BH AF Knapik, Joseph J. Marin, Roberto E. Grier, Tyson L. Jones, Bruce H. TI A systematic review of post-deployment injury-related mortality among military personnel deployed to conflict zones SO BMC PUBLIC HEALTH LA English DT Review ID GULF-WAR VETERANS; POSTTRAUMATIC-STRESS-DISORDER; NATIONAL-DEATH-INDEX; VIETNAM-ERA VETERANS; UNITED-STATES-ARMY; DESERT-STORM VETERANS; MOTOR-VEHICLE CRASHES; FOLLOW-UP; PERSIAN-GULF; POSTSERVICE MORTALITY AB Background: This paper reports on a systematic review of the literature on the post-conflict injury-related mortality of service members who deployed to conflict zones. Methods: Literature databases, reference lists of articles, agencies, investigators, and other sources were examined to find studies comparing injury-related mortality of military veterans who had served in conflict zones with that of contemporary veterans who had not served in conflict zones. Injury-related mortality was defined as a cause of death indicated by International Classification of Diseases E-codes E800 to E999 (external causes) or subgroupings within this range of codes. Results: Twenty studies met the review criteria; all involved veterans serving during either the Vietnam or Persian Gulf conflict. Meta-analysis indicated that, compared with non-conflict-zone veterans, injury-related mortality was elevated for veterans serving in Vietnam (summary mortality rate ratio (SMRR) = 1.26, 95% confidence interval (95%CI) = 1.08-1.46) during 9 to 18 years of follow-up. Similarly, injury-related mortality was elevated for veterans serving in the Persian Gulf War (SMRR = 1.26, 95%CI = 1.16-1.37) during 3 to 8 years of follow-up. Much of the excess mortality among conflict-zone veterans was associated with motor vehicle events. The excess mortality decreased over time. Hypotheses to account for the excess mortality in conflict-zone veterans included post-traumatic stress, coping behaviors such as substance abuse, ill-defined diseases and symptoms, lower survivability in injury events due to conflict-zone comorbidities, altered perceptions of risk, and/or selection processes leading to the deployment of individuals who were risk-takers. Conclusion: Further research on the etiology of the excess mortality in conflict-zone veterans is warranted to develop appropriate interventions. C1 [Knapik, Joseph J.; Grier, Tyson L.; Jones, Bruce H.] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD USA. [Marin, Roberto E.] Womack Army Med Ctr, Dept Occupat Med, Ft Bragg, NC USA. RP Knapik, JJ (reprint author), USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD USA. EM joseph.knapik@us.army.mil; roberto.estaban.marin@us.army.mil; tyson.grier@us.army.mil; bruce.h.jones@us.army.mil NR 115 TC 17 Z9 18 U1 2 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA CURRENT SCIENCE GROUP, MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD JUL 13 PY 2009 VL 9 AR 231 DI 10.1186/1471-2458-9-231 PG 22 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 480VX UT WOS:000268766200002 PM 19594931 ER PT J AU Lambrechts, L Chevillon, C Albright, RG Thaisomboonsuk, B Richardson, JH Jarman, RG Scott, TW AF Lambrechts, Louis Chevillon, Christine Albright, Rebecca G. Thaisomboonsuk, Butsaya Richardson, Jason H. Jarman, Richard G. Scott, Thomas W. TI Genetic specificity and potential for local adaptation between dengue viruses and mosquito vectors SO BMC EVOLUTIONARY BIOLOGY LA English DT Article ID AEDES-AEGYPTI POPULATIONS; QUANTITATIVE TRAIT LOCI; ORAL INFECTION; PUERTO-RICO; SUSCEPTIBILITY; EVOLUTION; STRAINS; SELECTION; THAILAND; TRANSMISSION AB Background: Several observations support the hypothesis that vector-driven selection plays an important role in shaping dengue virus (DENV) genetic diversity. Clustering of DENV genetic diversity at a particular location may reflect underlying genetic structure of vector populations, which combined with specific vector genotype x virus genotype (G x G) interactions may promote adaptation of viral lineages to local mosquito vector genotypes. Although spatial structure of vector polymorphism at neutral genetic loci is well-documented, existence of G x G interactions between mosquito and virus genotypes has not been formally demonstrated in natural populations. Here we measure G x G interactions in a system representative of a natural situation in Thailand by challenging three isofemale families from field-derived Aedes aegypti with three contemporaneous low-passage isolates of DENV-1. Results: Among indices of vector competence examined, the proportion of mosquitoes with a midgut infection, viral RNA concentration in the body, and quantity of virus disseminated to the head/legs (but not the proportion of infected mosquitoes with a disseminated infection) strongly depended on the specific combinations of isofemale families and viral isolates, demonstrating significant G x G interactions. Conclusion: Evidence for genetic specificity of interactions in our simple experimental design indicates that vector competence of Ae. aegypti for DENV is likely governed to a large extent by G x G interactions in genetically diverse, natural populations. This result challenges the general relevance of conclusions from laboratory systems that consist of a single combination of mosquito and DENV genotypes. Combined with earlier evidence for fine-scale genetic structure of natural Ae. aegypti populations, our finding indicates that the necessary conditions for local DENV adaptation to mosquito vectors are met. C1 [Lambrechts, Louis; Albright, Rebecca G.; Scott, Thomas W.] Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA. [Lambrechts, Louis; Chevillon, Christine] Ctr Rech IRD, CNRS IRD, UMR 2724, F-34394 Montpellier 5, France. [Thaisomboonsuk, Butsaya; Jarman, Richard G.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Richardson, Jason H.] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. RP Lambrechts, L (reprint author), Univ Calif Davis, Dept Entomol, 1 Shields Ave, Davis, CA 95616 USA. EM Louis.Lambrechts@mpl.ird.fr; Christine.Chevillon@mpl.ird.fr; rgalbright@ucdavis.edu; ButsayaT@afrims.org; Jason.Richardson@afrims.org; Richard.Jarman@afrims.org; twscott@ucdavis.edu RI Lambrechts, Louis/A-2057-2010; Richardson, Jason/A-9441-2011; Chevillon, Christine/L-4645-2013 OI Lambrechts, Louis/0000-0001-5958-2138; Chevillon, Christine/0000-0002-1262-5839 FU French CNRS program 'Maladies Infectieuses Emergentes' FX The authors thank Jittawadee Murphy, Prasan Kankaew, Somporn Changimongkol, Thanyalak Fansiri, Siriporn Phasomkusolsil, Yossasin Kertmanee, Kanchana Pantuwatana, and Jaruwan Tawong for technical assistance during mosquito collections. We are grateful to William Reisen and Aaron Brault for their continuous support through access to the Center for Vectorborne Disease Research. Thanks to Ying Fang, Sandy Garcia, Keira Simmons, Stanley Langevin and Rajeev Vaidyanathan for their help with cell culture and virological assays, and to two anonymous reviewers for valuable comments on an earlier version of the manuscript. LL is supported by a post-doctoral Marie Curie Outgoing International Fellowship from the 6th Framework Program of the European Commission. This work was partially funded by the French CNRS program 'Maladies Infectieuses Emergentes'. NR 58 TC 76 Z9 77 U1 4 U2 28 PU BIOMED CENTRAL LTD PI LONDON PA CURRENT SCIENCE GROUP, MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1471-2148 J9 BMC EVOL BIOL JI BMC Evol. Biol. PD JUL 9 PY 2009 VL 9 AR 160 DI 10.1186/1471-2148-9-160 PG 11 WC Evolutionary Biology; Genetics & Heredity SC Evolutionary Biology; Genetics & Heredity GA 479QA UT WOS:000268674800001 PM 19589156 ER PT J AU Pfenning, MJ AF Pfenning, Michael J. TI Quantization of the Maxwell field in curved spacetimes of arbitrary dimension SO CLASSICAL AND QUANTUM GRAVITY LA English DT Article ID RELATIVISTIC WAVE-EQUATIONS; TIME ORDERED PRODUCTS; RIEMANN SPACES; QUANTUM-FIELDS; COMPATIBILITY AB We quantize the massless p-form field that obeys the generalized Maxwell field equations in curved spacetimes of dimension n >= 2. We begin by showing that the classical Cauchy problem of the generalized Maxwell field is well posed and that the field possesses the expected gauge invariance. Then the classical phase space is developed in terms of gauge-equivalent classes, first in terms of the Cauchy data and then reformulated in terms of Maxwell solutions. The latter is employed to quantize the field in the framework of Dimock. Finally, the resulting algebra of observables is shown to satisfy the wave equation with the usual canonical commutation relations. C1 US Mil Acad, Dept Phys, West Point, NY 10996 USA. RP Pfenning, MJ (reprint author), US Mil Acad, Dept Phys, West Point, NY 10996 USA. EM Michael.Pfenning@usma.edu NR 34 TC 15 Z9 15 U1 0 U2 1 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND SN 0264-9381 J9 CLASSICAL QUANT GRAV JI Class. Quantum Gravity PD JUL 7 PY 2009 VL 26 IS 13 AR 135017 DI 10.1088/0264-9381/26/13/135017 PG 20 WC Astronomy & Astrophysics; Physics, Multidisciplinary; Physics, Particles & Fields SC Astronomy & Astrophysics; Physics GA 459VH UT WOS:000267139100017 ER PT J AU Horovitz, SG Braun, AR Carr, WS Picchioni, D Balkin, TJ Fukunaga, M Duyn, JH AF Horovitz, Silvina G. Braun, Allen R. Carr, Walter S. Picchioni, Dante Balkin, Thomas J. Fukunaga, Masaki Duyn, Jeff H. TI Decoupling of the brain's default mode network during deep sleep SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE EEG; fMRI; resting state; connectivity; consciousness ID RESTING HUMAN BRAIN; CAT VISUAL-CORTEX; FUNCTIONAL CONNECTIVITY; BOLD SIGNAL; SPONTANEOUS FLUCTUATIONS; COGNITIVE NEUROSCIENCE; STATE; CONSCIOUSNESS; FMRI; ARCHITECTURE AB The recent discovery of a circuit of brain regions that is highly active in the absence of overt behavior has led to a quest for revealing the possible function of this so-called default-mode network (DMN). A very recent study, finding similarities in awake humans and anesthetized primates, has suggested that DMN activity might not simply reflect ongoing conscious mentation but rather a more general form of network dynamics typical of complex systems. Here, by performing functional MRI in humans, it is shown that a natural, sleep-induced reduction of consciousness is reflected in altered correlation between DMN network components, most notably a reduced involvement of frontal cortex. This suggests that DMN may play an important role in the sustenance of conscious awareness. C1 [Horovitz, Silvina G.] Natl Inst Neurol Disorders & Stroke, Human Motor Control Sect, Med Neurol Branch, NIH, Bethesda, MD 20892 USA. [Horovitz, Silvina G.; Fukunaga, Masaki; Duyn, Jeff H.] Natl Inst Neurol Disorders & Stroke, Adv MRI, Lab Funct & Mol Imaging, NIH, Bethesda, MD 20892 USA. [Braun, Allen R.] Natl Inst Deafness & Other Commun Disorders, Language Sect, Voice Speech & Language Branch, NIH, Bethesda, MD 20892 USA. [Carr, Walter S.] USN, Med Res Ctr, Silver Spring, MD 20910 USA. [Picchioni, Dante; Balkin, Thomas J.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD 20910 USA. RP Horovitz, SG (reprint author), Natl Inst Neurol Disorders & Stroke, Human Motor Control Sect, Med Neurol Branch, NIH, Bethesda, MD 20892 USA. EM silvina.horovitz@nih.gov RI Duyn, Jozef/F-2483-2010; Sanguansri, Luz/B-6630-2011; Fukunaga, Masaki/F-6441-2013 OI Sanguansri, Luz/0000-0003-1908-7604; Fukunaga, Masaki/0000-0003-1010-2644 FU Intramural NIH HHS NR 47 TC 247 Z9 252 U1 10 U2 31 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD JUL 7 PY 2009 VL 106 IS 27 BP 11376 EP 11381 DI 10.1073/pnas.0901435106 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 468DX UT WOS:000267796100091 PM 19549821 ER PT J AU Nersisyan, S Tabiryan, N Steeves, DM Kimball, BR AF Nersisyan, Sarik Tabiryan, Nelson Steeves, Diane M. Kimball, Brian R. TI Fabrication of liquid crystal polymer axial waveplates for UV-IR wavelengths SO OPTICS EXPRESS LA English DT Article ID HOLOGRAPHIC OPTICAL TWEEZERS; SPIRAL PHASE PLATE; POLARIZATION CONVERTERS; SYMMETRIC POLARIZATION; LASER-BEAMS; WAVE-FRONT; DISLOCATIONS; VORTICES; GRATINGS; FILTER AB We show the opportunity of fabricating axially symmetric waveplates fine tuned to a desired wavelength. High quality waveplates are obtained using liquid crystal polymer layers on photoaligning substrates extending their functional range from UV to IR wavelengths. We characterize the effect of the waveplate on laser beams showing formation of a doughnut beam with over 240 times attenuation of intensity on the axis. We pay attention that the power density is strongly reduced on the doughnut ring as well and use this opportunity for taking charge coupled devices (CCDs) out of a deep saturation regime. Strong deformation of the beam profile is observed when the vortex axis is shifted towards the periferies of the beam. We demonstrate feasibility of using this phenomenon for shaping the profile of light beams with a set of waveplates. (C) 2009 Optical Society of America C1 [Nersisyan, Sarik; Tabiryan, Nelson] Beam Engn Adv Measurements Co, Winter Pk, FL 32789 USA. [Steeves, Diane M.; Kimball, Brian R.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Nersisyan, S (reprint author), Beam Engn Adv Measurements Co, 809 S Orlando Ave,Suite 1, Winter Pk, FL 32789 USA. EM Brian.R.Kimball@us.army.mil NR 25 TC 39 Z9 39 U1 1 U2 16 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD JUL 6 PY 2009 VL 17 IS 14 BP 11926 EP 11934 DI 10.1364/OE.17.011926 PG 9 WC Optics SC Optics GA 467RX UT WOS:000267761200071 PM 19582107 ER PT J AU Shulkla, MK Dubey, M Zakar, E Leszczynski, J AF Shulkla, Manoj K. Dubey, Madan Zakar, Eugene Leszczynski, Jerzy TI Electronic Structures and Properties of Pd-n-C-60-Pd-n Nanocontacts: A Theoretical Investigation SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID DENSITY-FUNCTIONAL THEORY; MOLECULAR DEVICES; CARBON NANOTUBES; TRANSPORT; C-60; JUNCTIONS; DYNAMICS; METALS; SIZE AB Theoretical study at the B3LYP/6-31G(d)ULANL2DZ level was carried out to explore the structures and properties of nanocontacts in Pd-n-C-60-Pd-n Systems. Predicted interaction energies between the palladium clusters and the C-60 were corrected for the basis set superposition error. It is revealed that palladium clusters interact more strongly with C-60 than the analogous gold clusters. Further, generally in the case of C-60-Pd complexes, electronic charges are transferred from metal Clusters to C-60 which is contrary to the direction of a charge transfer in C-60-Au complexes. HOMO-LUMO energy gaps in Pd-n-C-60-Pd-n system are found to be lower than C-60 as well as the corresponding Au-n-C-60-Au-n complexes. Charge transport properties in the Pd-n-C-60-Pd-n system are discussed in terms of molecular Orbitals and the Fermi energy level. Molecular electrostatic potential (MEP) mappings were performed for the qualitative visualization of the Schottky barrier at the C-60-Pd interface. Similarity and differences between the Pd-n-C-60-Pd-n and Au-n-C-60-Au-n systems are also explored. C1 [Shulkla, Manoj K.; Leszczynski, Jerzy] Jackson State Univ, NSF CREST Interdisplinary Nanotox Ctr, Dept Chem & Biochem, Jackson, MS 39217 USA. [Dubey, Madan; Zakar, Eugene] USA, Res Lab, Sensors & Electron Devices Directorate, AMSRD ARL SE RL, Adelphi, MD 20783 USA. RP Leszczynski, J (reprint author), Jackson State Univ, NSF CREST Interdisplinary Nanotox Ctr, Dept Chem & Biochem, Jackson, MS 39217 USA. EM jerzy@icnanotox.org FU Army Research Laboratory [DAAD 19-03-R-0017, W911QX-07-C-0100]; NSF-CREST [HRD-0833178]; ONR [N00014-08-1-0324] FX M.K.S. and J.L. are thankful to financial support from Army Research Laboratory BAA# DAAD 19-03-R-0017, section # 2.41, Contract No. W911QX-07-C-0100, NSF-CREST Grant No. HRD-0833178, ONR Grant No. N00014-08-1-0324, and the Mississippi Center for Supercomputing Research (MCSR) for the generous computational facility. NR 43 TC 7 Z9 7 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD JUL 2 PY 2009 VL 113 IS 26 BP 11351 EP 11357 DI 10.1021/jp900370h PG 7 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 462CW UT WOS:000267324600027 ER PT J AU Shivakumar, K Lingaiah, S Chen, HC Akangah, P Swaminathan, G Russell, L AF Shivakumar, Kunigal Lingaiah, Shivalingappa Chen, Huanchun Akangah, Paul Swaminathan, Gowthaman Russell, Larry, Jr. TI Polymer Nanofabric Interleaved Composite Laminates SO AIAA JOURNAL LA English DT Article; Proceedings Paper CT AIAA/ASME/ASCE/AHS/ASC 50th Structures, Structural Dynamics, and Materials Conference CY MAY 02-07, 2009 CL Palm Springs, CA SP AIAA, ASME, ASCE, AHS, ASC AB The concept of electrospun polymer nanofiber fabric interleaving to enhance dynamic properties, impact damage resistance, fracture toughness and resistance, and delamination onset life was evaluated. Polymer nanofabric interleaving increased the laminate thickness and weight by an order of 1%, and its impact on in-plane mechanical properties of the composite laminate would be statistically zero. On the other hand, its influence on interlaminar fracture toughness and resistance, impact damage resistance, and damping is substantial. Results of this study showed that interleaving AS4/3501-6 composite laminate increased the damping by 13%, reduced the impact damage size to one-third, increased fracture toughness and resistance by 1.5 times and one-third, respectively, significantly increased delamination onset life, and increased the fatigue threshold energy release rate by two-thirds. These improvements are comparable to that of the commercial T800H/3900-2 composite but with no thickness increase penalty, loss of in-plane properties, or multiple glass transition temperatures. C1 [Shivakumar, Kunigal; Lingaiah, Shivalingappa; Chen, Huanchun; Akangah, Paul; Swaminathan, Gowthaman] N Carolina Agr & Tech State Univ, Dept Mech & Chem Engn, Ctr Composite Mat Res, Greensboro, NC 27411 USA. [Russell, Larry, Jr.] USA, Res Off, Div Environm Sci, Res Triangle Pk, NC 27709 USA. RP Shivakumar, K (reprint author), N Carolina Agr & Tech State Univ, Dept Mech & Chem Engn, Ctr Composite Mat Res, Greensboro, NC 27411 USA. NR 26 TC 19 Z9 21 U1 2 U2 7 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0001-1452 J9 AIAA J JI AIAA J. PD JUL PY 2009 VL 47 IS 7 BP 1723 EP 1729 DI 10.2514/1.41791 PG 7 WC Engineering, Aerospace SC Engineering GA 466QB UT WOS:000267676100014 ER PT J AU McClung, JP Karl, JP Cable, SJ Williams, KW Nindl, BC Young, AJ Lieberman, HR AF McClung, James P. Karl, J. Philip Cable, Sonya J. Williams, Kelly W. Nindl, Bradley C. Young, Andrew J. Lieberman, Harris R. TI Randomized, double-blind, placebo-controlled trial of iron supplementation in female soldiers during military training: effects on iron status, physical performance, and mood SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article ID PREVIOUSLY UNTRAINED WOMEN; DEFICIENCY ANEMIA; WORK CAPACITY; UNITED-STATES; BLOOD-LOSS; US-ARMY; EXERCISE; HEPCIDIN; SLEEP; RUNNERS AB Background: Decrements in iron status have been reported in female soldiers during military training. Diminished iron status adversely affects physical and cognitive performance. Objective: We wanted to determine whether iron supplementation could prevent decrements in iron status and improve measures of physical performance and cognitive status in female soldiers during basic combat training (BCT). Design: In this 8-wk randomized, double-blind, placebo-controlled trial, soldier volunteers (n = 219) were provided with capsules containing either 100 mg ferrous sulfate or a placebo. Iron status indicator assays were performed pre- and post-BCT. Two-mile running time was assessed post-BCT; mood was assessed by using the Profile of Mood States questionnaire pre- and post-BCT. Results: The BCT course affected iron status: red blood cell distribution width and soluble transferrin receptor were elevated (P < 0.05), and serum ferritin was lowered (P < 0.05) post-BCT. Iron supplementation attenuated the decrement in iron status; group-by-time interactions (P < 0.01) were observed for serum ferritin and soluble transferrin receptor. Iron supplementation resulted in improved (P < 0.05) vigor scores on the Profile of Mood States post-BCT and in faster running time (P < 0.05) in volunteers reporting to BCT with iron deficiency anemia. Conclusions: Iron status is affected by BCT, and iron supplementation attenuates the decrement in indicators of iron status in female soldiers. Furthermore, iron supplementation may prove to be beneficial for mood and physical performance during the training period. Future efforts should identify and treat female soldiers or athletes who begin training regimens with iron deficiency or iron deficiency anemia. Am J Clin Nutr 2009;90:124-31. C1 [McClung, James P.; Karl, J. Philip; Young, Andrew J.; Lieberman, Harris R.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Nindl, Bradley C.] USARIEM, Mil Performance Div, Natick, MA 01760 USA. [Cable, Sonya J.; Williams, Kelly W.] Directorate Basic Combat Training, Ft Jackson, SC USA. RP McClung, JP (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. EM james.mcclung@amedd.army.mil RI McClung, James/A-1989-2009; OI Karl, J. Philip/0000-0002-5871-2241 FU US Army Medical Research and Materiel Command FX Supported by the US Army Medical Research and Materiel Command. NR 54 TC 60 Z9 62 U1 3 U2 21 PU AMER SOC CLINICAL NUTRITION PI BETHESDA PA 9650 ROCKVILLE PIKE, SUBSCRIPTIONS, RM L-3300, BETHESDA, MD 20814-3998 USA SN 0002-9165 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD JUL 1 PY 2009 VL 90 IS 1 BP 124 EP 131 DI 10.3945/ajcn.2009.27774 PG 8 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 462RK UT WOS:000267373200017 PM 19474138 ER PT J AU Aungst, MJ Friedman, EB von Pechmann, WS Horbach, NS Welgoss, JA AF Aungst, Matthew J. Friedman, Evan B. von Pechmann, Walter S. Horbach, Nicolette S. Welgoss, Jeffrey A. TI De novo stress incontinence and pelvic muscle symptoms after transvaginal mesh repair SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article; Proceedings Paper CT 29th Annual Meeting of the American-Urogynecologic-Society CY SEP 04-06, 2008 CL Chicago, IL SP Amer Urogynecol Soc DE dyspareunia; stress urinary incontinence; surgical mesh; uterine prolapse ID INTERNATIONAL CONTINENCE SOCIETY; RANDOMIZED CONTROLLED-TRIAL; ORGAN PROLAPSE REPAIR; URINARY-INCONTINENCE; POLYPROPYLENE MESH; SEXUAL FUNCTION; STANDARDIZATION; SACROCOLPOPEXY; TERMINOLOGY; BURCH AB OBJECTIVE: We sought to determine the rate of de novo stress incontinence, pelvic muscle symptoms, mesh exposure, visceral injury rate, and recurrent prolapse after transvaginal mesh repair. STUDY DESIGN: We conducted a retrospective review of 335 consecutive women with stage II or worse vaginal prolapse who underwent Prolift (Ethicon, Somerville, NJ) between July 7, 2005 and Jan. 31, 2008. RESULTS: In all, 71% underwent total Prolift, 20% anterior, and 8% posterior alone. Average age was 62 years and mean follow-up was 8 months. The intraoperative visceral injury rate was 6.6%, mesh expo-sure rate was 3.8%, and recurrent failure rate was 5.2%. The postoperative de novo stress incontinence rate was 24.3%. In this series, 18% of women had pelvic muscle symptoms postoperatively; 74% of these resolved within 6 months with conservative management. CONCLUSION: After Prolift, surgeons can expect a low rate of recurrent prolapse and mesh exposure. However, pelvic muscle dysfunction and de novo stress incontinence will be encountered postoperatively in a moderate number of women. C1 [Aungst, Matthew J.] Walter Reed Army Med Ctr, Div Female Pelv Med & Reconstruct Surg, Dept Obstet & Gynecol, Washington, DC 20307 USA. [Friedman, Evan B.] George Washington Univ, Dept Obstet & Gynecol, Washington, DC USA. [von Pechmann, Walter S.; Horbach, Nicolette S.; Welgoss, Jeffrey A.] No Virginia Pelv Surg Associates, Annandale, VA USA. RP Aungst, MJ (reprint author), Walter Reed Army Med Ctr, Div Female Pelv Med & Reconstruct Surg, Dept Obstet & Gynecol, Bldg 2,Room 2J06,6900 Georgia Ave, Washington, DC 20307 USA. EM Matt.Aungst@yahoo.com NR 28 TC 9 Z9 9 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JUL PY 2009 VL 201 IS 1 AR 73.e1 DI 10.1016/j.ajog.2009.02.028 PG 7 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 465PM UT WOS:000267599300029 PM 19393596 ER PT J AU Rong, C AF Rong, Charles TI Real or Imagined Limits? SO AMERICAN SCIENTIST LA English DT Letter C1 USA, Res Lab, Adelphi, MD USA. RP Rong, C (reprint author), USA, Res Lab, Adelphi, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU SIGMA XI-SCI RES SOC PI RES TRIANGLE PK PA PO BOX 13975, RES TRIANGLE PK, NC 27709 USA SN 0003-0996 J9 AM SCI JI Am. Scientist PD JUL-AUG PY 2009 VL 97 IS 4 BP 269 EP 269 PG 1 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 456LF UT WOS:000266847100008 ER PT J AU Dragovich, A Weber, T Wenzell, D Verdolin, MH Cohen, SP AF Dragovich, Anthony Weber, Thomas Wenzell, Daniel Verdolin, Michael H. Cohen, Steven P. TI Neuromodulation in Patients Deployed to War Zones SO ANESTHESIA AND ANALGESIA LA English DT Article ID SPINAL-CORD STIMULATION; REGIONAL PAIN SYNDROME; SURGERY; OPIOIDS AB Four active duty military personnel and two retired soldiers/military contractors were treated with spinal or peripheral nerve stimulators. All six personnel were able to deploy after the stimulators were placed. Five patients had no incidents during their deployments. One patient completed four deployments but had mechanical complications that necessitated eventual revisions. Considering the risks and limitations of reoperation, nerve blocks, and pharmacotherapy in a forward-deployed area, spinal cord stimulation provides an appealing alternative in soldiers who desire to remain deployable on active duty. (Anesth Analg 2009:109:245-8) C1 [Dragovich, Anthony; Weber, Thomas] Womack Army Med Ctr, Dept Surg, Ft Bragg, NC USA. [Wenzell, Daniel] Madigan Army Med Ctr, Dept Surg, Tacoma, WA 98431 USA. [Verdolin, Michael H.] USN, San Diego Med Ctr, Dept Anesthesiol, San Diego, CA 92152 USA. [Cohen, Steven P.] Johns Hopkins Sch Med, Dept Anesthesiol, Baltimore, MD USA. [Cohen, Steven P.] Johns Hopkins Sch Med, Dept Crit Care Med, Baltimore, MD USA. [Cohen, Steven P.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. RP Dragovich, A (reprint author), 25 Bay Point, Sanford, NC 27332 USA. EM dragov3@mac.com NR 9 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD JUL PY 2009 VL 109 IS 1 BP 245 EP 248 DI 10.1213/ane.0b013e3181a3368e PG 4 WC Anesthesiology SC Anesthesiology GA 461NT UT WOS:000267275100040 PM 19535717 ER PT J AU Haymore, BR DeZee, KJ AF Haymore, Bret R. DeZee, Kent J. TI USE OF ANGIOTENSIN RECEPTOR BLOCKERS AFTER ANGIOEDEMA WITH AN ANGIOTENSIN-CONVERTING ENZYME INHIBITOR SO ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY LA English DT Letter ID INTOLERANT; TRIAL; RISK C1 [Haymore, Bret R.] Walter Reed Army Med Ctr, Dept Allergy Immunol, Washington, DC 20307 USA. [DeZee, Kent J.] William Beaumont Army Med Ctr, Dept Internal Med, El Paso, TX 79920 USA. RP Haymore, BR (reprint author), Walter Reed Army Med Ctr, Dept Allergy Immunol, Washington, DC 20307 USA. EM bret.haymore@us.army.mil NR 5 TC 8 Z9 8 U1 0 U2 0 PU AMER COLL ALLERGY ASTHMA IMMUNOLOGY PI ARLINGTON HTS PA 85 WEST ALGONQUIN RD SUITE 550, ARLINGTON HTS, IL 60005 USA SN 1081-1206 J9 ANN ALLERG ASTHMA IM JI Ann. Allergy Asthma Immunol. PD JUL PY 2009 VL 103 IS 1 BP 83 EP 84 PG 2 WC Allergy; Immunology SC Allergy; Immunology GA 471EV UT WOS:000268039300018 PM 19663135 ER PT J AU Matsueda, S Gao, H Efferson, CL Tsuda, N Ishiyama, S Li, YF Ioannides, MG Fisk, B Peoples, GE Ioannides, CG AF Matsueda, Satoko Gao, Hui Efferson, Clayton L. Tsuda, Naotake Ishiyama, Satoshi Li, Yufeng Ioannides, Maria G. Fisk, Bryan Peoples, George E. Ioannides, Constantin G. TI N-Terminally LRMK-linked HER-2 peptides, AE-37 [p776(774-788)] and AE-47 [Ava-F7(776-788)], Aid Differentiation of E75-TCR(+)CD8(+) Cells to Perforin-positive Cells SO ANTICANCER RESEARCH LA English DT Article DE HER-2; helper effect; AE-37; AE-47; p776; F7; perforin; E75; cancer vaccines; high-affinity CD8(+) cells ID BREAST-CANCER PATIENTS; CLASS-II MOLECULES; INVARIANT CHAIN; CLINICAL-TRIAL; LYMPH-NODE; RESPONSES; EPITOPES; VACCINES; COMPLEX; TUMOR AB The objective of this study was to discover whether the peptides LRMK and LRMK-Ava linked to the N-terminus of peptides HER-2 (774-788) and HER-2 (776788), respectively, help differentiation of E75-TCR(+)CD8(+) cells. Activation was quantified in terms of proliferation of E75-TCR(+)CD8(+) cells expressing high, medium and low density amounts of the specific TCR. Differentiation to functional CD8(+) cells was quantified as induction of Perforin (Perf), the lytic-enzyme which mediates the effector function of CD8(+) cells, in E75-TCR(+)CD8(+) cells. Peripheral blood mononuclear cells (PBMCs) of 3 patients activated with E75(+)AE-37 and E75(+)AE-47 more greatly increased the number of E75-TCR(Hi) CD8(+)Perf(+) cells than PBMCs activated by AE-47 alone or AE-47(+) E75. E75 plus cytokines and cytokines alone activated more E75-TCR(Low) cells than did AE-37 and AE-47. E75(+) AE-37 and AE-37 also induced differentiation of small- and medium-size activated CD8(+) cells from BRC ascites, in allogeneic activation, to Perf(+) cells. Preferential differentiation of E75-TCR(+)CD8(+)Perf(+) cells in distinct patients by AE-37 and AE-47 indicates that cancer vaccines will benefit from such correct individual and disease-associated help. Additional studies using the natural peptides p776 and F7 are needed to understand whether the LRMK-(Ava) tetra-, or pentamer augments or inhibits differentiation of CD8(+) cells, compared with native, natural HER-2 peptides and/or protects CD8(+) cells activated by E75 and by other HLA-I bound peptides from death. Our findings also develop a model for uniform quantification of differentiated CD8(+) effectors. C1 [Ioannides, Constantin G.] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA. [Matsueda, Satoko; Efferson, Clayton L.; Tsuda, Naotake; Ishiyama, Satoshi; Li, Yufeng; Ioannides, Constantin G.] Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol, Houston, TX 77030 USA. [Gao, Hui] Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX 77030 USA. [Li, Yufeng] Univ Texas MD Anderson Canc Ctr, Dept Melanoma Med Oncol, Houston, TX 77030 USA. [Ioannides, Maria G.] Natl Tech Univ Athens, Dept Elect Engn, Athens, Greece. [Fisk, Bryan] Walter Reed Army Med Ctr, Dept Acute Care, Washington, DC 20307 USA. [Peoples, George E.] Ft Brooks Army Med Ctr, Dept Surg, San Antonio, TX USA. RP Ioannides, CG (reprint author), Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Box 304,1515 Holcombe Blvd, Houston, TX 77030 USA. EM cioannid@mdanderson.org FU NIH-MDACC [CA-16660]; DOD [01-1-0299]; Patent Licensing Funds (Apthera Co); Keck Foundation; Eustathios and Euphrosina Maroulis Memorial Fund; European Union Socrates and Jean Monet grant funds from Maria G. and Fotini G. Ioannides; Department of Defense of USA FX This study was supported by NIH-MDACC Core CA-16660 to Peptide Synthesis Laboratory, DOD-Grant-01-1-0299 (SI, NT, CGI), Patent Licensing Funds (Apthera Co), Keck Foundation, Eustathios and Euphrosina Maroulis Memorial Fund, European Union Socrates and Jean Monet grant funds from Maria G. and Fotini G. Ioannides (Athens, Greece) (P-50 NIH-Melanoma Spore to EA Grimm) and funds from the Department of Defense of USA to BF and GEP. NR 29 TC 0 Z9 0 U1 0 U2 2 PU INT INST ANTICANCER RESEARCH PI ATHENS PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22, ATHENS 19014, GREECE SN 0250-7005 J9 ANTICANCER RES JI Anticancer Res. PD JUL PY 2009 VL 29 IS 7 BP 2427 EP 2435 PG 9 WC Oncology SC Oncology GA 472BM UT WOS:000268104100002 PM 19596910 ER PT J AU Deaver, DM Flug, E Boettcher, E Smith, SR Miller, B AF Deaver, Dawne M. Flug, Eric Boettcher, Evelyn Smith, Stevie R. Miller, Brian TI Infrared sensor modeling for human activity discrimination tasks in urban and maritime environments SO APPLIED OPTICS LA English DT Article ID IDENTIFICATION; CRITERIA AB The United States military is increasingly using infrared (IR) sensors to discriminate the actions and intentions of people being observed in an area of interest; however, there is currently inadequate modeling capability to a priori determine the effectiveness of IR sensors for these types of tasks. The U.S. Army's NVTherm model is a military and industry standard sensor performance model that estimates target acquisition performance based on both the sensor design parameters and an empirically measured calibration factor to represent human observer performance. Historically the model has been calibrated by presenting static imagery to observers and measuring average probabilities of accomplishing the given task. The task of human activity discrimination, however, presents new challenges to the model, as "activity" inherently implies a dynamic scene where motion cues are essential in accomplishing the task. A series of studies has been completed in order to calibrate NVTherm for the task of human activity discrimination. The challenges involved in representing the human activity task, the establishment of new processing methods, and new standards for defining simple target metrics for complex imagery are discussed. The experiments that have supported the calculation of new calibration parameters are also described. These efforts have brought the U.S. Army significantly closer to having a sensor performance model validated for discriminating human activity with IR sensors. (C) 2009 Optical Society of America C1 [Deaver, Dawne M.; Flug, Eric; Smith, Stevie R.; Miller, Brian] USA, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. [Boettcher, Evelyn] DCS Corp, Alexandria, VA 22314 USA. RP Deaver, DM (reprint author), USA, Night Vis & Elect Sensors Directorate, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. EM dawne.m.deaver@us.army.mil FU ONR FX The authors gratefully acknowledge Dr. Keith Krapels, formerly of the ONR, for the financial and technical support of the maritime portion of this study. NR 9 TC 4 Z9 4 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JUL 1 PY 2009 VL 48 IS 19 BP 3537 EP 3556 DI 10.1364/AO.48.003537 PG 20 WC Optics SC Optics GA 477LI UT WOS:000268520200003 PM 19571908 ER PT J AU Kilby, GR Gaylord, TK AF Kilby, Gregory R. Gaylord, Thomas K. TI Fourier transform infrared transmission microspectroscopy of photonic crystal structures SO APPLIED OPTICS LA English DT Article ID WAVE-GUIDE AB The detailed microscopic characterization of photonic crystal (PC) structures is challenging due to their small sizes. Generally, only the gross macroscopic behavior can be determined. This leaves in question the performance at the basic structure level. The single-incident-angle plane-wave transmittances of one-dimensional photonic crystal (PC) structures are extracted from multiple-incident-angle, focused-beam measurements. In the experimental apparatus, an infrared beam is focused by a reflecting microscope objective to produce an incident beam. This beam can be modeled as multiple, variable-intensity plane waves incident on the PC structure. The transmittance of the structure in response to a multiple-incident-angle composite beam is measured. The composite beam measurement is repeated at various incident angle orientations with respect to the sample normal so that, at each angular orientation, the included set of single-angle plane-wave components is unique. A set of measurements recorded over a range of angular orientations results in an underspecified matrix algebra problem. Regularization techniques can be applied to the problem to extract the single-angle plane-wave response of the structure from the composite measurements. Experimental results show very good agreement between the measured and theoretical single-angle plane-wave transmittances. (C) 2009 Optical Society of America C1 [Kilby, Gregory R.] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. [Kilby, Gregory R.] US Mil Acad, Photon Res Ctr, West Point, NY 10996 USA. [Gaylord, Thomas K.] Georgia Inst Technol, Sch Elect & Comp Engn, Atlanta, GA 30332 USA. RP Kilby, GR (reprint author), US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. EM gregory.kilby@usma.edu FU Army Research Office [DAAD19-03-1-0286] FX This work was supported by the Army Research Office under grant DAAD19-03-1-0286. NR 13 TC 1 Z9 1 U1 0 U2 4 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JUL 1 PY 2009 VL 48 IS 19 BP 3716 EP 3721 DI 10.1364/AO.48.003716 PG 6 WC Optics SC Optics GA 477LI UT WOS:000268520200023 PM 19571928 ER PT J AU Bazar, MA Quinn, MJ Mozzachio, K Bleiler, JA Archer, CR Phillips, CT Johnson, MS AF Bazar, Matthew A. Quinn, Michael J., Jr. Mozzachio, Kristie Bleiler, John A. Archer, Christine R. Phillips, Carlton T. Johnson, Mark S. TI Toxicological Responses of Red-Backed Salamanders (Plethodon cinereus) to Soil Exposures of Copper SO ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article ID TERRESTRIAL SALAMANDER; 2,4,6-TRINITROTOLUENE; BIOACCUMULATION; BIOAVAILABILITY; TOXICITY AB Copper (Cu) has widespread military use in munitions and small arms, particularly as a protective jacket for lead projectiles. The distribution of Cu at many US military sites is substantial and sites of contamination include habitats in and around military storage facilities, manufacturing, load and packing plants, open burning/open detonation areas, and firing ranges. Some of these areas include habitat for amphibian species, which generally lack toxicity data for risk assessment purposes. In an effort to ascertain Cu concentrations in soil that are toxic to terrestrial amphibians, 100 red-backed salamanders (Plethodon cinereus) were randomly sorted by weight, assigned to either a control soil or one of four treatments amended with copper acetate in soil, and exposed for 28 days. Analytical mean soil concentrations were 18, 283, 803, 1333, and 2700 mg Cu/kg soil dry weight. Food consisted of uncontaminated flightless Drosophila melanogaster. Survival was reduced in salamanders exposed to 1333 and 2700 mg/kg by 55% and 100%, respectively. Mortality/morbidity occurred within the first 4 days of exposure. These data suggest that a Cu soil concentration of and exceeding 1333.3 +/- A 120.2 mg/kg results in reduced survival, whereas hematology analyses suggest that a concentration of and exceeding 803.3 +/- A 98.4 mg/kg might result in reduced total white blood cell count. No effects were observed at 283.3 +/- A 36.7 mg/kg. C1 [Bazar, Matthew A.; Quinn, Michael J., Jr.; Johnson, Mark S.] USA, Ctr Hlth Promot & Prevent Med, Directorate Toxicol, Aberdeen Proving Ground, MD 21010 USA. [Mozzachio, Kristie] Biotechnics Inc, Hillsborough, NC 27278 USA. [Bleiler, John A.; Archer, Christine R.] ENSR Corp, Westford, MA USA. [Phillips, Carlton T.] Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. RP Bazar, MA (reprint author), USA, Ctr Hlth Promot & Prevent Med, Directorate Toxicol, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM Matthew.Bazar@us.army.mil FU Environmental Security Technology Certification Program [ESTCP ER 0514] FX We thank Chuck Stoner and the Directorate of Laboratory Sciences for analytical support and Robyn Lee for statistical help. We thank the entire team on ER 0514, namely Doris (Andy) Anders, David Barclift, Amy Hawkins, John Noles, and David Pillard. This work was funded by the Environmental Security Technology Certification Program (ESTCP ER 0514). The views expressed in this work are those of the authors and do not necessarily reflect the views and policies of the US Army. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 27 TC 6 Z9 6 U1 0 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0090-4341 J9 ARCH ENVIRON CON TOX JI Arch. Environ. Contam. Toxicol. PD JUL PY 2009 VL 57 IS 1 BP 116 EP 122 DI 10.1007/s00244-008-9232-4 PG 7 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 448MH UT WOS:000266266200013 PM 18825446 ER PT J AU Lieberman, HR Castellani, JW Young, AJ AF Lieberman, Harris R. Castellani, John W. Young, Andrew J. TI Cognitive Function and Mood During Acute Cold Stress After Extended Military Training and Recovery SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE sleep deprivation; vigilance; chronic stress; environmental stress; fatigue; military; mood; performance ID SLEEP LOSS; SUSTAINED OPERATIONS; ENVIRONMENTAL-STRESS; VISUAL VIGILANCE; PERFORMANCE; CAFFEINE; UNDERNUTRITION; DEPRIVATION; HYPOTHERMIA; DECREMENTS AB Introduction: Acute cold stress is often accompanied by exposure to other adverse factors, such as sleep loss, under-nutrition, and psychological stress that singly and together may affect cognitive function.. Methods: I-lie effect of moderate cold stress on cognitive function was investigated in 15 male volunteers exposed to cold air (10 degrees C) for 4 h after they had completed in intense, 61-d regimen (U.S. Army Ranger training). The single cohort of volunteers was tested on three separate occasions: 1) immediately after completing Ranger training; 2) 2 d later when they had partially recovered from training; 3) 108 d later after full recovery. Documented training stressors included limited sleep (similar to 4 h sleep/night), caloric deficit (similar to 850 kcal . d(-1)), intense physical activity, and psychological stress. Results: Baseline rectal temperature fell significantly due to training alone (from 36.6 degrees C +/- 0.1 to 36.3 degrees C +/- 0.1) and was lower still with acute cold exposure (35.9 degrees C +/- 0.2). Cognitive function was affected by training alone, as indicated by significant decreases in vigilance, four-choice reaction time, pattern recognition, symbol-digit substitution, word-list learning, grammatical reasoning, and mood prior to exposure to acute cold stress. Mood states were also adversely affected, including tension, depression, anger, fatigue, confusion, and vigor. Acute cold exposure itself significantly degraded vigilance, overall mood, and increased tension. Discussion: Chronic multifactorial stress impaired cognitive function and mood; the addition of moderate, acute cold stress further degraded vigilance and mood. When such circumstances occur, such as during disasters or military operations, measures to prevent adverse cognitive and physiological outcomes are recommended. C1 [Lieberman, Harris R.; Young, Andrew J.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Castellani, John W.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Lieberman, HR (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Bldg 42, Natick, MA 01760 USA. EM harris.lieberman@us.army.mil NR 37 TC 23 Z9 24 U1 6 U2 16 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD JUL PY 2009 VL 80 IS 7 BP 629 EP 636 DI 10.3357/ASEM.2431.2009 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 464TS UT WOS:000267530700007 PM 19601505 ER PT J AU Wang, XY Pang, JH Maffucci, JA Pade, DS Newman, RA Kerwin, SM Bowman, PD Stavchansky, S AF Wang, Xinyu Pang, Jihai Maffucci, Jacqueline A. Pade, Devendra S. Newman, Robert A. Kerwin, Sean M. Bowman, Phillip D. Stavchansky, Salomon TI Pharmacokinetics of Caffeic Acid Phenethyl Ester and its Catechol-ring Fluorinated Derivative Following Intravenous Administration to Rats SO BIOPHARMACEUTICS & DRUG DISPOSITION LA English DT Article DE caffeic acid phenethyl ester; fluorinated caffeic acid phenethyl ester; rats; dose proportionality; pharmacokinetics ID HUMAN ENDOTHELIAL-CELLS; NF-KAPPA-B; HEME OXYGENASE-1; EPITHELIAL-CELLS; NUCLEAR-FACTOR; EXPRESSION; PLASMA; CAPE; INFLAMMATION; METASTASIS AB The pharmacokinetic profiles of caffeic acid phenethyl ester (CAPE) and its catechol-ring fluorinated derivative (FCAPE) were determined in rats after intravenous administration of 5, 10 or 20 mg/kg for CAPE and 20 mg/kg for FCAPE, respectively. The plasma concentrations of CAPE and FCAPE were measured using a validated liquid chromatography tandem mass spectrometric method. The pharmacokinetic parameters were estimated using lion compartmental analysis (NCA) and biexponential fit. The results showed that the area under the plasma concentration-time curve for CAPE treatment increased in a proportion greater than the increase in dose from 5 to 20 mg/kg of CAPE. Total body clearance values for CAPE ranged from 42.1 to 172 ml/min/kg (NCA) and decreased with the increasing dose of CAPE. Similarly, the volume of distribution values for CAPE ranged from 1555 to 5209 ml/kg, decreasing with increasing dose. The elimination half-life for CAPE ranged from 21.2 to 26.7 min and was independent of dose. That FCAPE was distributed extensively into rat tissues and eliminated rapidly was indicated by a high value of volume of distribution and similar short elimination half-life as that of CAPE. Copyright (C) 2009 John Wiley & Sons, Ltd. C1 [Wang, Xinyu; Pade, Devendra S.; Stavchansky, Salomon] Univ Texas Austin, Coll Pharm, Div Pharmaceut, Austin, TX 78712 USA. [Pang, Jihai; Newman, Robert A.] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77054 USA. [Maffucci, Jacqueline A.] Univ Texas Austin, Dept Pharmacol & Toxicol, Austin, TX 78712 USA. [Kerwin, Sean M.] Univ Texas Austin, Div Med Chem, Austin, TX 78712 USA. [Kerwin, Sean M.] Univ Texas Austin, Inst Mol & Cellular Biol, Inst Cellular & Mol Biol, Austin, TX 78712 USA. [Wang, Xinyu; Bowman, Phillip D.] USA, Inst Surg Res, San Antonio, TX 78234 USA. RP Stavchansky, S (reprint author), Univ Texas Austin, Coll Pharm, Div Pharmaceut, Austin, TX 78712 USA. EM stavchansky@mail.utexas.edu OI Kerwin, Sean/0000-0001-8432-6558 NR 28 TC 31 Z9 31 U1 1 U2 7 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 0142-2782 J9 BIOPHARM DRUG DISPOS JI Biopharm. Drug Dispos. PD JUL PY 2009 VL 30 IS 5 BP 221 EP 228 DI 10.1002/bdd.657 PG 8 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 476DW UT WOS:000268419200001 PM 19544289 ER PT J AU Li, X Li, YH Zhong, ZK Wang, DH Ratto, JA Sheng, KC Sun, XS AF Li, Xin Li, Yonghui Zhong, Zhikai Wang, Donghai Ratto, Jo A. Sheng, Kuichuan Sun, Xiuzhi Susan TI Mechanical and water soaking properties of medium density fiberboard with wood fiber and soybean protein adhesive SO BIORESOURCE TECHNOLOGY LA English DT Article DE Mechanical properties; Medium density fiberboard (MDF); Soybean protein adhesive; Water soaking properties ID MODIFIED SOY PROTEIN; WHEAT-STRAW PARTICLEBOARD; SODIUM DODECYL-SULFATE; STRENGTH; RESISTANCE AB Soybean protein is a renewable and abundant material that offers an alternative to formaldehyde-based resins. In this study, soybean protein was modified with sodium dodecyl sulfate (SIDS) as an adhesive for wood fiber medium density fiberboard (MDF) preparation. Second-order response surface regression models were used to study the effects and interactions of initial moisture content (IMC) of coated wood fiber, press time (PT) and temperature on mechanical and water soaking properties of MDF. Results showed that IMC of coated fiber was the dominant influencing factor. Mechanical and soaking properties improved as IMC increased and reached their highest point at an IMC of 35%. Press time and temperature also had a significant effect on mechanical and water soaking properties of MDF. Second-order regression results showed that there were strong relationships between mechanical and soaking properties of MDF and processing parameters. Properties of MDF made using soybean protein adhesive are similar to those of commercial board. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Li, Xin; Li, Yonghui; Zhong, Zhikai; Sun, Xiuzhi Susan] Kansas State Univ, Dept Grain Sci & Ind, Biomat & Technol Lab, Manhattan, KS 66506 USA. [Wang, Donghai] Kansas State Univ, Dept Biol & Agr Engn, Manhattan, KS 66506 USA. [Ratto, Jo A.] USA, Natick Res Dev & Engn Ctr, Combat Feeding Directorate, Natick, MA 01760 USA. [Sheng, Kuichuan] Zhejiang Univ, Dept Biosyst Engn, Hangzhou 310029, Zhejiang, Peoples R China. RP Sun, XS (reprint author), Kansas State Univ, Dept Grain Sci & Ind, Biomat & Technol Lab, 101 BIVAP Bldg,1980 Kimball Ave, Manhattan, KS 66506 USA. EM xss@ksu.edu RI LI, Yonghui/E-8925-2011 FU U.S. Department of Defense, Strategic Environmental Research and Development Program; US Department of Agricultural Kansas Experiment Station [08-390-J] FX The authors thank the U.S. Department of Defense, Strategic Environmental Research and Development Program for providing partial financial support of this research. Contribution grant sponsor is US Department of Agricultural Kansas Experiment Station (08-390-J). NR 24 TC 45 Z9 48 U1 2 U2 33 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0960-8524 J9 BIORESOURCE TECHNOL JI Bioresour. Technol. PD JUL PY 2009 VL 100 IS 14 BP 3556 EP 3562 DI 10.1016/j.biortech.2009.02.048 PG 7 WC Agricultural Engineering; Biotechnology & Applied Microbiology; Energy & Fuels SC Agriculture; Biotechnology & Applied Microbiology; Energy & Fuels GA 446XA UT WOS:000266153700017 PM 19329303 ER PT J AU Nguyen, DN Kim, P Martinez-Sobrido, L Beitzel, B Garcia-Sastre, A Langer, R Anderson, DG AF Nguyen, David N. Kim, Phillip Martinez-Sobrido, Luis Beitzel, Brett Garcia-Sastre, Adolfo Langer, Robert Anderson, Daniel G. TI A Novel High-Throughput Cell-Based Method for Integrated Quantification of Type I Interferons and In Vitro Screening of Immunostimulatory RNA Drug Delivery SO BIOTECHNOLOGY AND BIOENGINEERING LA English DT Article DE RNA interference; siRNA; immunostimulatory RNA; drug delivery; high-throughput screening; innate immunity ID SINGLE-STRANDED RNA; PLASMACYTOID DENDRITIC CELLS; BLOOD MONONUCLEAR-CELLS; SYNTHETIC SIRNA; IFN-ALPHA; INDUCTION; VIRUS; DESIGN; COMBINATORIAL; STIMULATION AB A hallmark of immune activation by certain RNA sequences is the generation of interferon responses. However, the study of immunostimulatory RNA (isRNA) has been hindered by costly and slow methods, particularly in vitro. We have developed a cell-based assay to detect human type I interferon (IFN) that reliably senses both IFN-alpha and IFN-beta simultaneously. The human 293T cell line was stably transfected with a fusion gene of,monomeric red fluorescent protein (mRFP) under the transcriptional control of an interferon-stimulated response element (ISRE). High levels of mRFP are expressed following activation of the type I IFN receptor (IFNAR). Using this method, detection limits for IFN similar to that of ELISA can be achieved but with a greater dynamic range and in a high-throughput manner, As a proof of concept, we utilized this method to screen a library of cationic lipid-like materials that form nanoparticle complexes with RNA for induction of innate immune responses in vitro. We expect the screening and detection methods described herein may provide a useful tool in elucidating mechanisms that govern the delivery of RNA molecules to effector cells and receptors of the innate immune system. We apply this tool to investigate isRNA drug delivery, but it may also find use in other applications for which high-throughput detection of type I IFN is desired. Biotechnol. Bioeng. Biotechnol. Bioeng. 2009;103: 664-675. (c) 2009 Wiley Periodicals, Inc. C1 [Langer, Robert; Anderson, Daniel G.] MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA. [Garcia-Sastre, Adolfo] Mt Sinai Sch Med, Global Hlth & Emerging Pathogens Inst, New York, NY USA. [Garcia-Sastre, Adolfo] Mt Sinai Sch Med, Dept Med, Div Infect Dis, New York, NY USA. [Beitzel, Brett] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Martinez-Sobrido, Luis; Garcia-Sastre, Adolfo] Mt Sinai Sch Med, Dept Microbiol, New York, NY USA. [Kim, Phillip; Langer, Robert] MIT, Dept Chem Engn, Cambridge, MA 02139 USA. [Nguyen, David N.; Langer, Robert] MIT, Div Hlth Sci & Technol, Cambridge, MA 02139 USA. RP Anderson, DG (reprint author), MIT, David H Koch Inst Integrat Canc Res, E25-342,45 Carleton St, Cambridge, MA 02139 USA. EM dgander@mit.edu OI Garcia-Sastre, Adolfo/0000-0002-6551-1827 FU NIH [EB000244, U19AI62623, U54AI57158] FX The authors Wish to acknowledge the expert help of Glenn Paradis of the David H. Koch Institute for Integrative Cancer Research Flow Cytometry C ore Facility, valuable discussions with Prof. Jianzhu Chen, and funding support from NIH Grants EB000244, U19AI62623, and U54AI57158. NR 33 TC 13 Z9 14 U1 0 U2 8 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0006-3592 J9 BIOTECHNOL BIOENG JI Biotechnol. Bioeng. PD JUL 1 PY 2009 VL 103 IS 4 BP 664 EP 675 DI 10.1002/bit.22312 PG 12 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 474MZ UT WOS:000268289500004 PM 19338049 ER PT J AU Wu, HY Rusiecki, JA Zhu, KM Potter, J Devesa, SS AF Wu, Hongyu Rusiecki, Jennifer A. Zhu, Kangmin Potter, John Devesa, Susan S. TI Stomach Carcinoma Incidence Patterns in the United States by Histologic Type and Anatomic Site SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION LA English DT Article ID GASTRIC CARDIA CARCINOMAS; HELICOBACTER-PYLORI; CANCER INCIDENCE; CHANGING PATTERNS; MORTALITY TRENDS; ESOPHAGEAL; METAANALYSIS; DIFFUSE; WHITES; ADENOCARCINOMAS AB Background: Using data from the U.S. National Cancer Institute's Surveillance, Epidemiology, and End Results program, we analyzed stomach carcinoma incidence patterns by both histologic type and anatomic site. Methods: We calculated age-adjusted (2000 U.S. standard) rates for 1978 to 2005, and for five time periods from 1978-1983 through 2001-2005 according to histologic type and anatomic site, separately and jointly. We also analyzed rates by race, gender, and age group. Results: During 1978 to 2005, more than 54,000 stomach carcinoma cases were diagnosed among residents of the nine Surveillance, Epidemiology, and End Results areas. Total stomach carcinoma rates declined by 34% from the 1978-1983 to the 2001-2005 time periods. By histologic type, intestinal rates decreased consistently, whereas those for diffuse rates increased through 2000 and declined in recent years. By anatomic site, cardia rates increased during earlier years and then decreased, whereas rates for all other sites declined. When considered jointly by histologic type and anatomic site, intestinal carcinoma rates decreased for all sites except the cardia; diffuse rates increased through 2000 and decreased in recent years for all sites except the overlapping/nonspecified sites. Both diffuse and intestinal rates were lowest among whites, intermediate among blacks, and highest among the other, primarily Asian, races, with only modest gender differences for the diffuse type. In contrast, cardia carcinoma rates were highest among whites and were notably higher among males, especially whites among whom the male/female rate ratio was five to one. Conclusions: Stomach carcinoma incidence patterns differ by histologic type, anatomic site, race, gender, and age, suggesting that etiologic heterogeneity should be pursued in future research. (Cancer Epidemiol Biomarkers Prev 2009;18(7):1945-52) C1 [Devesa, Susan S.] NCI, Div Canc Epidemiol & Genet, Rockville, MD 20850 USA. [Wu, Hongyu; Zhu, Kangmin; Potter, John] US Mil Canc Inst, Walter Reed Army Med Ctr, Washington, DC USA. [Rusiecki, Jennifer A.; Zhu, Kangmin] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. RP Devesa, SS (reprint author), NCI, Div Canc Epidemiol & Genet, 6120 Execut Blvd,Room 8048, Rockville, MD 20850 USA. EM devesas@mail.nih.gov FU National Cancer Institute; NIH; The United States Military Cancer Institute via the Uniformed Services University; Henry M. Jackson Foundation FX Intramural Research Program of the National Cancer Institute, the NIH and The United States Military Cancer Institute via the Uniformed Services University, of the Health Sciences under the auspices of the Henry M. Jackson Foundation for the Advancement of Military Medicine. NR 40 TC 59 Z9 62 U1 0 U2 6 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1055-9965 J9 CANCER EPIDEM BIOMAR JI Cancer Epidemiol. Biomarkers Prev. PD JUL PY 2009 VL 18 IS 7 BP 1945 EP 1952 DI 10.1158/1055-9965.EPI-09-0250 PG 8 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA 471LR UT WOS:000268059700001 PM 19531677 ER PT J AU Huang, LH Xie, J Chen, RR Chu, D Hsu, AT AF Huang, Lihong Xie, Jian Chen, Rongrong Chu, Deryn Hsu, Andrew T. TI Fe Promoted Ni-Ce/Al2O3 in Auto-Thermal Reforming of Ethanol for Hydrogen Production SO CATALYSIS LETTERS LA English DT Article DE Hydrogen production; Nickel catalyst; Ceria promoter; Iron promoter; Auto-thermal reforming; Ethanol ID NICKEL-BASED CATALYSTS; NI-BASED CATALYSTS; GAS-SHIFT REACTION; PARTIAL OXIDATION; STEAM; CROTONALDEHYDE; METHANE; IRON; CE AB Ni-Ce/Al2O3 and Ni-Ce-Fe/Al2O3 catalysts prepared by impregnation were tested in auto-thermal reforming (ATR) of ethanol. With ceria promotion, conversion of ethanol near 100% and selectivity to hydrogen at 103.6% can be achieved at 600 degrees C in ATR of ethanol, while with both iron and ceria promotion, selectivity to hydrogen at 118.4% is observed, which are higher (57.17% improvement on hydrogen selectivity) than that of the conventional Ni catalyst. In addition, higher stability is also observed during a 31-h test. The improvements are attributed to the restrained acidity and high dispersion of nickel alumina spinel phase. C1 [Hsu, Andrew T.] Indiana Univ Purdue Univ, Purdue Sch Engn & Technol, Indianapolis, IN 46202 USA. [Huang, Lihong; Xie, Jian; Chen, Rongrong; Hsu, Andrew T.] Indiana Univ Purdue Univ, Lugar Ctr Renewable Energy, Indianapolis, IN 46202 USA. [Chu, Deryn] USA, Res Lab, Adelphi, MD 20783 USA. RP Hsu, AT (reprint author), Indiana Univ Purdue Univ, Purdue Sch Engn & Technol, 799 W Michigan St,ET 215, Indianapolis, IN 46202 USA. EM anhsu@iupui.edu FU U. S. Army Research Lab [W911NF-07-2-0036] FX This work is partially supported by the U. S. Army Research Lab (Grant No. W911NF-07-2-0036). The authors wish to thank Dr. Jeffrey Swope of Department of Geography Science at IUPUI for XRD test, and acknowledge the useful discussions provided by Drs. Corinne Renguette, Wei Sun and Haixia Li. NR 26 TC 13 Z9 13 U1 1 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1011-372X J9 CATAL LETT JI Catal. Lett. PD JUL PY 2009 VL 130 IS 3-4 BP 432 EP 439 DI 10.1007/s10562-009-9978-y PG 8 WC Chemistry, Physical SC Chemistry GA 462EP UT WOS:000267330300025 ER PT J AU Thompson, ML Casey, FXM Khan, E Hakk, H Larsen, GL DeSutter, T AF Thompson, Michael L. Casey, Francis X. M. Khan, Eakalak Hakk, Heldur Larsen, Gerald L. DeSutter, Thomas TI Occurrence and pathways of manure-borne 17 beta-estradiol in vadose zone water SO CHEMOSPHERE LA English DT Article DE Estrogens; Estradiol; Hormone; Soil; Vadose zone; Lysimeter ID ESTROGENIC HORMONES; AGRICULTURAL SOILS; TESTOSTERONE; TRANSPORT; SORPTION; SAMPLERS; TRACERS; FATE; TRANSFORMATION; DEGRADATION AB The hormone 17 beta-estradiol (E2) can cause endocrine disruption in sensitive species at part per trillion concentrations. The persistence and transport pathways of manure-borne E2 in agricultural soils were determined by comparing its occurrence with the transfer of water and the transport of non-sorbing fluorobenzoic acid (FBA) tracers. This comparison was done using capillary wick lysimeters installed 0.61 m beneath three corn (Zea mays L.) plots that receive swine (Sus scrofa domesticus) manure from various sources. An additional control plot was included that received no manure. Soil water transfer was modeled to compare actual versus predicted percolation. On average, lysimeters collected 61% of the expected percolation and 8% of the FBA. There were frequent E2 detections, where there were an average of 8 detections for the 11 sample events. The average detection was 21 ng L-1 and its range was 1-245 ng L-1. 17 beta-Estradiol was detected before manure was applied and also in the control plot lysimeters. Furthermore, the average mass recovery of E2 in all the lysimeters was >50%, which was greater than the FBA tracer recovery. Results indicated that tracer was transported with precipitated water infiltrating into the soil surface and percolating down through the soil profile. There was substantial evidence for antecedent E2, which was persistent and mobile. The persistence and mobility of the E2 may result from its associations with colloids, such as dissolved organic matter. Furthermore, this antecedent E2 appeared to overwhelm any observable effect of manure management on E2 fate and transport. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Casey, Francis X. M.; DeSutter, Thomas] N Dakota State Univ, Sch Nat Resource Sci, Dept Soil Sci, Fargo, ND 58108 USA. [Thompson, Michael L.] USA, CO C, Baltimore, MD 21224 USA. [Khan, Eakalak] N Dakota State Univ, Dept Civil Engn, Fargo, ND 58108 USA. [Hakk, Heldur; Larsen, Gerald L.] ARS, Anim Metabolite & Agr Chem Unit, Biosci Res Lab, USDA, Fargo, ND 58105 USA. RP Casey, FXM (reprint author), N Dakota State Univ, Sch Nat Resource Sci, Dept Soil Sci, Fargo, ND 58108 USA. EM francis.casey@ndsu.edu RI Casey, Francis/A-2135-2010 OI Casey, Francis/0000-0002-6035-7234 FU National Science Foundation [0730492] FX This research was based upon work supported by the National Science Foundation under Grant No. 0730492. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation. The authors greatly appreciate the tremendous contributions made by Mr. Nathan E. Derby, Mrs. Barbara K. Magelky, Mrs. Colleen M. Pfaff, and Mrs. Kimberly Zitnick. NR 38 TC 20 Z9 25 U1 0 U2 14 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD JUL PY 2009 VL 76 IS 4 BP 472 EP 479 DI 10.1016/j.chemosphere.2009.03.037 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA 462NU UT WOS:000267361800007 PM 19394677 ER PT J AU King, CS Collen, J Holley, AB Greenburg, D Hnatiuk, O AF King, Christopher S. Collen, Jacob Holley, Aaron B. Greenburg, David Hnatiuk, Oleh TI Discordance in Spirometric Interpretations Using Different Reference Equations Response SO CHEST LA English DT Letter C1 [King, Christopher S.] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20350 USA. [Greenburg, David] Madigan Army Med Ctr, Seattle, WA USA. [Hnatiuk, Oleh] NHLBI, Bethesda, MD 20892 USA. RP King, CS (reprint author), Walter Reed Army Med Ctr, Dept Med, 6900 Georgia Ave, Washington, DC 20350 USA. EM christopher.king@amedd.army.mil NR 4 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD JUL PY 2009 VL 136 IS 1 BP 325 EP 325 DI 10.1378/chest.09-0820 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 467YG UT WOS:000267779000059 ER EF