FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Chung, K Wolf, S Cancio, L Renz, E King, B White, C Barillo, D Wade, C Blackbourne, L AF Chung, Kevin Wolf, Steven Cancio, Leopoldo Renz, Evan King, Booker White, Christopher Barillo, David Wade, Charles Blackbourne, Lorne TI BEST (BURN CENTER EVALUATION OF STANDARD THERAPIES) VENTILATOR MODE STUDY: A RANDOMIZED CONTROLLED TRIAL SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 39th Critical Care Congress of the Society-of-Critical-Care-Medicine CY JAN 09-13, 2010 CL Miami, FL SP Soc Critical Care Med, Pfizer Inc, Hospira Inc, Lippincott Williams & Wilkins C1 [Chung, Kevin; Cancio, Leopoldo; Renz, Evan; King, Booker; White, Christopher; Barillo, David; Wade, Charles; Blackbourne, Lorne] USA, Inst Surg Res, Washington, DC USA. [Wolf, Steven] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2009 VL 37 IS 12 SU S MA 14 BP A6 EP A6 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 529IS UT WOS:000272509900014 ER PT J AU Dubick, M Scherer, M Darlington, D Kheriabadi, B AF Dubick, Michael Scherer, Michael Darlington, Daniel Kheriabadi, Bijan TI EFFECTS OF ACIDOSIS AND PH CORRECTION ON THROMBIN GENERATION IN A SWINE HEMORRHAGE MODEL SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 39th Critical Care Congress of the Society-of-Critical-Care-Medicine CY JAN 09-13, 2010 CL Miami, FL SP Soc Critical Care Med, Pfizer Inc, Hospira Inc, Lippincott Williams & Wilkins C1 [Dubick, Michael; Scherer, Michael; Darlington, Daniel; Kheriabadi, Bijan] USA, Inst Surg Res, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2009 VL 37 IS 12 SU S MA 277 BP A125 EP A125 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 529IS UT WOS:000272509900244 ER PT J AU King, B Chung, K Renz, E Barillo, D Lundy, J Huzar, T Jones, J Cancio, L Wolf, S Blackbourne, L AF King, Booker Chung, Kevin Renz, Evan Barillo, David Lundy, Jonathan Huzar, Todd Jones, John Cancio, Leopoldo Wolf, Steven Blackbourne, Lorne TI COMPLICATIONS IN THE BURN INTENSIVE CARE UNIT: CIVILIAN VS. COMBAT CASUALTIES SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 39th Critical Care Congress of the Society-of-Critical-Care-Medicine CY JAN 09-13, 2010 CL Miami, FL SP Soc Critical Care Med, Pfizer Inc, Hospira Inc, Lippincott Williams & Wilkins C1 [Jones, John; Cancio, Leopoldo] USA, Inst Surg Res, Washington, DC USA. [Blackbourne, Lorne] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2009 VL 37 IS 12 SU S MA 623 BP A303 EP A303 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 529IS UT WOS:000272509900588 ER PT J AU Mann, E Jones, J Wolf, S Wade, C AF Mann, Elizabeth Jones, John Wolf, Steven Wade, Charles TI COMPUTER DECISION SUPPORT (ENDOTOOL (TM)) SAFELY IMPROVES GLYCEMIC CONTROL IN THE BURN ICU SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 39th Critical Care Congress of the Society-of-Critical-Care-Medicine CY JAN 09-13, 2010 CL Miami, FL SP Soc Critical Care Med, Pfizer Inc, Hospira Inc, Lippincott Williams & Wilkins C1 [Mann, Elizabeth; Jones, John; Wolf, Steven; Wade, Charles] USA, Inst Surg Res, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2009 VL 37 IS 12 SU S MA 166 BP A68 EP A68 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 529IS UT WOS:000272509900133 ER PT J AU Schlussel, A Holt, D Uyehara, C Crawley, E AF Schlussel, Andrew Holt, Danielle Uyehara, Catherine Crawley, Eric TI OUTCOMES OF BLOOD GLUCOSE VARIABILITY IN A MIXED MEDICAL SURGICAL INTENSIVE CARE UNIT SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 39th Critical Care Congress of the Society-of-Critical-Care-Medicine CY JAN 09-13, 2010 CL Miami, FL SP Soc Critical Care Med, Pfizer Inc, Hospira Inc, Lippincott Williams & Wilkins C1 [Schlussel, Andrew; Holt, Danielle; Uyehara, Catherine; Crawley, Eric] Tripler Army Med Ctr, Honolulu, HI USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2009 VL 37 IS 12 SU S MA 249 BP A110 EP A110 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 529IS UT WOS:000272509900216 ER PT J AU Shields, B Hurley, R Wade, C Aden, J Dawson, C Wolf, S AF Shields, Beth Hurley, Richard Wade, Charles Aden, James Dawson, Christopher Wolf, Steven TI EVALUATION OF URINARY PROTEIN LOSS IN MODERN BURN PATIENTS SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 39th Critical Care Congress of the Society-of-Critical-Care-Medicine CY JAN 09-13, 2010 CL Miami, FL SP Soc Critical Care Med, Pfizer Inc, Hospira Inc, Lippincott Williams & Wilkins C1 [Shields, Beth] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Hurley, Richard; Wade, Charles; Aden, James; Dawson, Christopher] USA, Inst Surg Res, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2009 VL 37 IS 12 SU S MA 186 BP A78 EP A78 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 529IS UT WOS:000272509900153 ER PT J AU Shields, B Dawson, C Aden, J Wolf, S Chung, K Hurley, R Wade, C AF Shields, Beth Dawson, Christopher Aden, James Wolf, Steven Chung, Kevin Hurley, Richard Wade, Charles TI BLOOD COAGULATION AND VITAMIN K STATUS IN BURNS SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 39th Critical Care Congress of the Society-of-Critical-Care-Medicine CY JAN 09-13, 2010 CL Miami, FL SP Soc Critical Care Med, Pfizer Inc, Hospira Inc, Lippincott Williams & Wilkins C1 [Shields, Beth] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Dawson, Christopher; Aden, James; Chung, Kevin; Hurley, Richard; Wade, Charles] USA, Inst Surg Res, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2009 VL 37 IS 12 SU S MA 182 BP A76 EP A76 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 529IS UT WOS:000272509900149 ER PT J AU Simmons, J Chung, K White, C Renz, E Lundy, J Hardin, M Jones, J Wolf, S Blackbourne, L AF Simmons, John Chung, Kevin White, Christopher Renz, Evan Lundy, Jonathan Hardin, Mark Jones, John Wolf, Steven Blackbourne, Lorne TI FENOLDOPAM USE IN A BURN ICU SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 39th Critical Care Congress of the Society-of-Critical-Care-Medicine CY JAN 09-13, 2010 CL Miami, FL SP Soc Critical Care Med, Pfizer Inc, Hospira Inc, Lippincott Williams & Wilkins C1 [Simmons, John] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Chung, Kevin; White, Christopher; Renz, Evan; Lundy, Jonathan; Hardin, Mark; Jones, John; Wolf, Steven; Blackbourne, Lorne] USA, Inst Surg Res, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2009 VL 37 IS 12 SU S MA 164 BP A67 EP A67 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 529IS UT WOS:000272509900131 ER PT J AU Simmons, J Chung, K White, C Hardin, M Mace, J Wolf, JS Wade, C Blackbourne, L AF Simmons, John Chung, Kevin White, Christopher Hardin, Mark Mace, James Wolf, Jones Steven Wade, Charles Blackbourne, Lorne TI AKIN STAGE ASSOCIATED WITH MORTALITY IN BURN ICU SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 39th Critical Care Congress of the Society-of-Critical-Care-Medicine CY JAN 09-13, 2010 CL Miami, FL SP Soc Critical Care Med, Pfizer Inc, Hospira Inc, Lippincott Williams & Wilkins C1 [Simmons, John; Mace, James] Brooke Army Med Ctr, San Antonio, TX USA. [Chung, Kevin; White, Christopher; Hardin, Mark; Wolf, Jones Steven; Wade, Charles; Blackbourne, Lorne] USA, Inst Surg Res, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2009 VL 37 IS 12 SU S MA 154 BP A62 EP A62 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 529IS UT WOS:000272509900121 ER PT J AU Zanders, T Batchinsky, A Chung, K Jordan, B Regn, D Burkett, S Nguyen, R Necsoiu, C Morris, M Cancio, L AF Zanders, Thomas Batchinsky, Andriy Chung, Kevin Jordan, Bryan Regn, Dara Burkett, Samuel Nguyen, Ruth Necsoiu, Corina Morris, Michael Cancio, Leopoldo TI COMPARISON OF AIRWAY PRESSURE RELEASE VENTILATION TO CONVENTIONAL VENTILATION IN A PORCINE MODEL OF SEVERE SMOKE INHALATION INJURY SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 39th Critical Care Congress of the Society-of-Critical-Care-Medicine CY JAN 09-13, 2010 CL Miami, FL SP Soc Critical Care Med, Pfizer Inc, Hospira Inc, Lippincott Williams & Wilkins C1 [Zanders, Thomas; Regn, Dara; Burkett, Samuel; Morris, Michael] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Batchinsky, Andriy; Chung, Kevin; Jordan, Bryan; Nguyen, Ruth; Necsoiu, Corina; Cancio, Leopoldo] USA, Inst Surg Res, Washington, DC USA. RI Necsoiu, Corina/A-6255-2013 NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2009 VL 37 IS 12 SU S MA 933 BP A457 EP A457 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 529IS UT WOS:000272509900896 ER PT J AU Nunez, TC Cotton, BA AF Nunez, Timothy C. Cotton, Bryan A. TI Transfusion therapy in hemorrhagic shock SO CURRENT OPINION IN CRITICAL CARE LA English DT Review DE damage control resuscitation; exsanguinations; hemorrhage; massive transfusion; trauma ID DAMAGE CONTROL RESUSCITATION; ACTIVATED FACTOR-VII; FRESH-FROZEN PLASMA; I TRAUMA CENTER; RECEIVING MASSIVE TRANSFUSIONS; LIFE-THREATENING COAGULOPATHY; COMBAT-RELATED CASUALTIES; BLOOD-PRODUCT UTILIZATION; CREW RESOURCE-MANAGEMENT; RECOMBINANT-FACTOR-VIIA AB Purpose of review Bleeding and death from hemorrhage remain a leading cause of morbidity and mortality in the trauma population. Early resuscitation of these gravely injured patients has changed significantly over the past several years, The concept of damage control resuscitation has expanded significantly with the experience of the US military in southwest Asia. This review will focus on this resuscitation strategy of transfusing blood products (red cells, plasma, and platelets) early and often in the exsanguinating patient. Recent findings In trauma there are no randomized controlled trials comparing the current damage control hematology concept to more traditional resuscitation methods. But the overwhelming conclusion of the data available support the administration of a high ratio of plasma and platelets to packed red blood cells. Several large retrospective studies have shown ratios close to 1 : 1 will result in higher survival. Summary The current evidence supports that the acute coagulopathy of trauma is present in a high percentage of trauma patients. Patients who will require a massive transfusion will have improved outcomes the earlier that this is identified and the earlier that damage control hematology is instituted. Current evidence does not describe the best ratio but the preponderance of the data suggests it should be greater than 2 : 3 plasma-to-packed red blood cells. C1 [Cotton, Bryan A.] Univ Texas Hlth Sci Ctr, Dept Surg, Div Acute Care Surg, Houston, TX 77030 USA. [Nunez, Timothy C.] Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. [Cotton, Bryan A.] Ctr Translat Injury Res, Houston, TX USA. RP Cotton, BA (reprint author), Univ Texas Hlth Sci Ctr, Dept Surg, Div Acute Care Surg, 6410 Fannin,Suite 1100, Houston, TX 77030 USA. EM bryan.a.cotton@uth.tmc.edu FU NIGMS NIH HHS [P50 GM038529-19, P50 GM038529] NR 83 TC 21 Z9 24 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1070-5295 J9 CURR OPIN CRIT CARE JI Curr. Opin. Crit. Care PD DEC PY 2009 VL 15 IS 6 BP 536 EP 541 DI 10.1097/MCC.0b013e328331575b PG 6 WC Critical Care Medicine SC General & Internal Medicine GA 524HX UT WOS:000272135500012 PM 19730099 ER PT J AU Keller, LR Baucells, M Butler, JC Delquie, P Merrick, JRW Parnell, GS Salo, A AF Keller, L. Robin Baucells, Manel Butler, John C. Delquie, Philippe Merrick, Jason R. W. Parnell, Gregory S. Salo, Ahti TI Untitled SO DECISION ANALYSIS LA English DT Editorial Material DE Bayesian statistics; Brier score; decision analysis; decision trees; finite additivity; game theory; influence diagrams; interview; mixed strategy; multiple objective decision analysis; Nash equilibrium; operations research practice; portfolio optimization; resource allocation; signaling game; simulation; editorial AB This issue's "From the Editors" column is coauthored with all the associate editors to emphasize their major role in the leadership of the journal. Our first article is on "Proper Scoring Rules, Dominated Forecasts, and Coherence," by Mark J. Schervish, Teddy Seidenfeld, and Joseph B. Kadane. In the second article, Jason R. W. Merrick provides an overview of "Bayesian Simulation and Decision Analysis: An Expository Survey." Our third article, by Barry R. Cobb and Atin Basuchoudhary, is on "A Decision Analysis Approach to Solving the Signaling Game." The next article, by Robert T. Clemen and James E. Smith, is "On the Choice of Baselines in Multiattribute Portfolio Analysis: A Cautionary Note." In our final article, Russ Garber presents "An Interview with Ronald A. Howard." C1 [Keller, L. Robin] Univ Calif Irvine, Irvine, CA 92697 USA. [Baucells, Manel] Univ Navarra, Barcelona 08034, Spain. [Butler, John C.] Univ Texas Austin, Austin, TX 78712 USA. [Delquie, Philippe] George Washington Univ, Washington, DC 20052 USA. [Merrick, Jason R. W.] Virginia Commonwealth Univ, Richmond, VA 23284 USA. [Parnell, Gregory S.] US Mil Acad, West Point, NY 10996 USA. [Salo, Ahti] Helsinki Univ Technol, Espoo 02015, HUT, Finland. RP Keller, LR (reprint author), Univ Calif Irvine, Irvine, CA 92697 USA. EM lrkeller@uci.edu; mbaucells@iese.edu; john.butler2@mccombs.utexas.edu; delquie@gwu.edu; jrmerric@vcu.edu; gregory.parnell@usma.edu; ahti.salo@tkk.fi RI Salo, Ahti/G-2412-2013 NR 31 TC 3 Z9 3 U1 0 U2 3 PU INFORMS PI HANOVER PA 7240 PARKWAY DR, STE 310, HANOVER, MD 21076-1344 USA SN 1545-8490 J9 DECIS ANAL JI Decis. Anal. PD DEC PY 2009 VL 6 IS 4 BP 199 EP 201 DI 10.1287/deca.1090.0165 PG 3 WC Management SC Business & Economics GA 535QJ UT WOS:000272985100001 ER PT J AU Ally, MR Veerappan, GR Maydonovitch, CL Duncan, TJ Perry, JL Osgard, EM Wong, RKH AF Ally, Mazer R. Veerappan, Ganesh R. Maydonovitch, Corinne L. Duncan, Timothy J. Perry, Joseph L. Osgard, Eric M. Wong, Roy K. H. TI Chronic Proton Pump Inhibitor Therapy Associated with Increased Development of Fundic Gland Polyps SO DIGESTIVE DISEASES AND SCIENCES LA English DT Article DE Proton pump inhibitor; Fundic gland polyps; Prevalence; Risk factors; Duration of the therapy ID FAMILIAL ADENOMATOUS POLYPOSIS; PARIETAL-CELL PROTRUSIONS; HIGH-GRADE DYSPLASIA; GASTRIC POLYPS; COLI GENE; RISK; OMEPRAZOLE; MUTATIONS; ADENOCARCINOMA; PATIENT AB Fundic gland polyps (FGP) have been implicated with long-term proton pump inhibitor (PPI) use. We attempted to investigate the impact of length and dosage of PPI therapy on the development of FGP. A retrospective cohort study of all patients who had gastric polyps removed during elective upper endoscopy between March and September 2007 as part of a prior prospective study protocol was carried out. FGP were determined histologically. Prior to endoscopy, all patients completed a questionnaire regarding PPI use and length of therapy (no PPI use, 1-48 months, > 48 months). The dosage of PPI was obtained via a thorough chart review of electronic medical records. Three hundred and eighty-five patients completed upper endoscopy and a questionnaire reporting PPI use (252 [65.4%] patients on PPI). On endoscopy, 55 patients had polyps, with the majority (43/55, 78%) being FGP, resulting in an overall prevalence of 11.1% (43/385). On univariate analysis, FGP were associated with Caucasian race (15 vs. 6%; P = 0.009) and chronic PPI therapy (> 48 months) (31.9 vs. 7.5%, P < 0.001). There was a significant linear-by-linear association between PPI dosage and FGP prevalence (no PPI use, 7.5%; once daily, 10.8%; twice daily 17.4%, P = 0.026). On logistic regression, the only independent predictor of FGP was duration of PPI use > 48 months (P = 0.001, odds ratio [OR] 4.7 [2.0-12.9]). The only independent predictor of FGP development in our study was duration of PPI therapy greater than 48 months. Increased dosage of therapy did not significantly impact the development of FGP. C1 [Ally, Mazer R.; Veerappan, Ganesh R.; Maydonovitch, Corinne L.; Duncan, Timothy J.; Perry, Joseph L.; Osgard, Eric M.; Wong, Roy K. H.] Walter Reed Army Med Ctr, Gastroenterol Serv, Dept Med, Washington, DC 20307 USA. [Ally, Mazer R.; Veerappan, Ganesh R.; Maydonovitch, Corinne L.; Duncan, Timothy J.; Perry, Joseph L.; Osgard, Eric M.; Wong, Roy K. H.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Veerappan, GR (reprint author), Walter Reed Army Med Ctr, Gastroenterol Serv, Dept Med, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM ganesh.veerappan@amedd.army.mil NR 36 TC 19 Z9 23 U1 0 U2 2 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0163-2116 J9 DIGEST DIS SCI JI Dig. Dis. Sci. PD DEC PY 2009 VL 54 IS 12 BP 2617 EP 2622 DI 10.1007/s10620-009-0993-z PG 6 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 521LQ UT WOS:000271923300012 PM 19830554 ER PT J AU O'Farrell, CR Heimsath, AM Lawson, DE Jorgensen, LM Evenson, EB Larson, G Denner, J AF O'Farrell, Colin R. Heimsath, Arjun M. Lawson, Daniel E. Jorgensen, Laura M. Evenson, Edward B. Larson, Grahame Denner, Jon TI Quantifying periglacial erosion: insights on a glacial sediment budget, Matanuska Glacier, Alaska SO EARTH SURFACE PROCESSES AND LANDFORMS LA English DT Article DE periglacial erosion; sediment yield; glaciation; (10)Be; cosmogenic nuclides ID SITU COSMOGENIC NUCLIDES; FREEZE-ON MECHANISM; RICH BASAL ICE; LANDSCAPE EVOLUTION; SOUTHERN ALASKA; NEW-ZEALAND; RATES; HOLOCENE; CLIMATE; RETREAT AB Glacial erosion rates are estimated to be among the highest in the world. Few studies have attempted, however, to quantify the flux of sediment from the periglacial landscape to a glacier. Here, erosion rates from the nonglacial landscape above the Matanuska Glacier, Alaska are presented and compare with an 8-yr record of proglacial suspended sediment yield. Non-glacial lowering rates range from 1.8 +/- 0.5 mm yr(-1) to 8.5 +/- 3.4 mm yr(-1) from estimates of rock fall and debris-flow fan volumes. An average erosion rate of 0.08 +/- 0.04 mm yr(-1) from eight convex-up ridge crests was determined using in situ produced cosmogenic (10)Be. Extrapolating these rates, based on landscape morphometry, to the Matanuska basin (58% ice-cover), it was found that nonglacial processes account for an annual sediment flux of 2.3 +/- 1.0 x 10(6) t. Suspended sediment data for 8 years and an assumed bedload to estimate the annual sediment yield at the Matanuska terminus to be 2.9 +/- 1.0 x 10(6) t, corresponding to an erosion rate of 1.8 +/- 0.6 mm yr(-1): nonglacial Sources therefore account for 80 +/- 45% of the proglacial yield. A similar set of analyses were used for a small tributary sub-basin (32%) ice-cover) to determine an erosion rate of 12.1 +/- 6.9 mm yr(-1), based on proglacial sediment yield, with the nonglacial sediment flux equal to 10 +/- 7% of the proglacial yield. It is suggested that erosion rates by nonglacial processes are similar to inferred subglacial rates, Such that the ice-free regions of a glaciated landscape contribute significantly to the glacial sediment budget. The similar magnitude of nonglacial and glacial rates implies that partially glaciated landscapes will respond rapidly to changes in climate and base level through a rapid nonglacial response to glacially driven incision. Copyright (C) 2009 John Wiley & Sons, Ltd. C1 [Heimsath, Arjun M.] Arizona State Univ, Sch Earth & Space Explorat, Tempe, AZ 85287 USA. [O'Farrell, Colin R.] Pioneer Nat Resources, Denver, CO 80202 USA. [Lawson, Daniel E.] CRREL, Hanover, NH 03755 USA. [Jorgensen, Laura M.] Shaw Grp, Denver, CO 80237 USA. [Evenson, Edward B.] Lehigh Univ, Dept Earth & Environm Sci, Bethlehem, PA 18015 USA. [Larson, Grahame] Michigan State Univ, Dept Geol Sci, E Lansing, MI 48824 USA. [Denner, Jon] USGS, Montpelier, VT 05601 USA. RP Heimsath, AM (reprint author), Arizona State Univ, Sch Earth & Space Explorat, Tempe, AZ 85287 USA. EM Arjun.Heimsath@asu.edu FU NSF [NSF-EAR-9909335, EAR-0239655]; Geological Society of America; Cold Regions Research and Engineering Laboratory (CRREL); Villhjalmur Stefensson Fellowship for Arctic Studies; Richter Memorial Trust; American Alpine Club FX We thank Bill and Kelly Stevenson for accommodation, bush plane flights, and help with general field logistics. Funding for this work was from NSF-EAR-9909335 and EAR-0239655 to AMH, Geological Society of America, the Cold Regions Research and Engineering Laboratory (CRREL), the Villhjalmur Stefensson Fellowship for Arctic Studies, the Richter Memorial Trust, and the American Alpine Club. Extensive reviews, including one from P Jansson on an earlier version, and editorial suggestions from S Lane have significantly helped this manuscript. NR 65 TC 10 Z9 10 U1 1 U2 13 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 0197-9337 J9 EARTH SURF PROC LAND JI Earth Surf. Process. Landf. PD DEC PY 2009 VL 34 IS 15 BP 2008 EP 2022 DI 10.1002/esp.1885 PG 15 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA 535HM UT WOS:000272958000003 ER PT J AU Hornstra, H Pearson, T Georgia, S Liguori, A Dale, J Price, E O'Neill, M DeShazer, D Muhammad, G Saqib, M Naureen, A Keim, P AF Hornstra, Heidie Pearson, Talima Georgia, Shalamar Liguori, Andrew Dale, Julia Price, Erin O'Neill, Matthew DeShazer, David Muhammad, Ghulam Saqib, Muhammad Naureen, Abeera Keim, Paul TI Molecular Epidemiology of Glanders, Pakistan SO EMERGING INFECTIOUS DISEASES LA English DT Article ID BURKHOLDERIA-PSEUDOMALLEI; AGENTS; MALLEI AB We collected epidemiologic and molecular data from Burkholderia mallei isolates from equines in Punjab, Pakistan from 1999 through 2007. We show that recent outbreaks are genetically distinct from available whole genome sequences and that these genotypes are persistent and ubiquitous in Punjab, probably because of human-mediated movement of equines. C1 [Hornstra, Heidie; Pearson, Talima; Georgia, Shalamar; Liguori, Andrew; Dale, Julia; Price, Erin; O'Neill, Matthew; Keim, Paul] No Arizona Univ, Flagstaff, AZ 86011 USA. [Price, Erin; Keim, Paul] Translat Genom Res Inst, Phoenix, AZ USA. [DeShazer, David] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Muhammad, Ghulam; Saqib, Muhammad] Univ Agr Faisalabad, Faisalabad, Pakistan. [Naureen, Abeera] Univ Vet & Anim Sci, Lahore, Pakistan. RP Keim, P (reprint author), No Arizona Univ, 1298 S Knoles Dr,Bldg 56,POB 4073, Flagstaff, AZ 86011 USA. EM paul.keim@nau.edu RI Keim, Paul/A-2269-2010; Price, Erin/N-2336-2013 OI Price, Erin/0000-0002-1079-4882 FU NIH-NIAID [U54AI-56359, U01AI-075568]; US Department of Homeland Security S&T CB Division of Bioforensics RD Program FX Ms Hornstra is a research project coordinator at the Microbial Genetics and Genomics Center at Northern Arizona University in Flagstaff. Her research interests focus on genetic diversity and evolutionary history of Burkholderia mallei, B. pseudomallei, and Coxiella burnetii. NR 15 TC 16 Z9 16 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD DEC PY 2009 VL 15 IS 12 BP 2036 EP 2039 DI 10.3201/eid1512.090738 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 527HO UT WOS:000272358200030 PM 19961695 ER PT J AU Efroymson, R Jager, H Dale, V Westervelt, J AF Efroymson, Rebecca Jager, Henriette Dale, Virginia Westervelt, James TI A Framework for Developing Management Goals for Species at Risk with Examples from Military Installations in the United States SO ENVIRONMENTAL MANAGEMENT LA English DT Review DE Endangered species; Military installations; Species at risk; Causal analysis; Threats; Rare species; Trend analysis; Threatened species; Recovery; Recovery goals ID POPULATION VIABILITY ANALYSIS; RED-COCKADED WOODPECKERS; COLORADO RIVER; RECOVERY PLANS; HUMPBACK CHUB; DETECTING TRENDS; ECOSYSTEM MANAGEMENT; EXTINCTION RISK; PROBABLE CAUSES; GRAND-CANYON AB A decision framework for setting management goals for species at risk is presented. Species at risk are those whose potential future rarity is of concern. Listing these species as threatened or endangered could potentially result in significant restrictions to activities in resource management areas in order to maintain those species. The decision framework, designed to foster proactive management, has nine steps: identify species at risk on and near the management area, describe available information and potential information gaps for each species, determine the potential distribution of species and their habitat, select metrics for describing species status, assess the status of local population or metapopulation, conduct threat assessment, set and prioritize management goals, develop species management plans, and develop criteria for ending special species management where possible. This framework will aid resource managers in setting management goals that minimally impact human activities while reducing the likelihood that species at risk will become rare in the near future. The management areas in many of the examples are United States (US) military installations, which are concerned about potential restrictions to military training capacity if species at risk become regulated under the US Endangered Species Act. The benefits of the proactive management set forth in this formal decision framework are that it is impartial, provides a clear procedure, calls for identification of causal relationships that may not be obvious, provides a way to target the most urgent needs, reduces costs, enhances public confidence, and, most importantly, decreases the chance of species becoming more rare. C1 [Efroymson, Rebecca; Jager, Henriette; Dale, Virginia] Oak Ridge Natl Lab, Div Environm Sci, Oak Ridge, TN 37831 USA. [Westervelt, James] USA, Construct Engn Res Lab, Engineer Res & Dev Ctr, Champaign, IL 61824 USA. RP Efroymson, R (reprint author), 132 Maple Dr Asheville, Asheville, NC 28805 USA. EM efroymsonra@ornl.gov OI Jager, Henriette/0000-0003-4253-533X; Efroymson, Rebecca/0000-0002-3190-880X FU US Army Corps' Engineer Research and Development Center; US Department of Energy [DE-AC05-00OR22725] FX We thank the US Army Corps' Engineer Research and Development Center for funding this work through the program on Habitat-centric Species at Risk (SAR) Research to Avoid Future Training Restrictions and the US Army Species at Risk Program. Dr. Tiomothy Hayden was the program manager. The project was conducted by Oak Ridge National Laboratory (ORNL), which is managed by the UT-Battelle, LLC, for the US Department of Energy under contract DE-AC05-00OR22725. Some of the information cited herein was provided by NatureServe (http://www.natureserve.org/) and its natural heritage member programs, a leading source of information about rare and endangered species, and threatened ecosystems. NR 107 TC 4 Z9 4 U1 0 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0364-152X J9 ENVIRON MANAGE JI Environ. Manage. PD DEC PY 2009 VL 44 IS 6 BP 1163 EP 1179 DI 10.1007/s00267-009-9385-6 PG 17 WC Environmental Sciences SC Environmental Sciences & Ecology GA 530TN UT WOS:000272615300012 PM 19830479 ER PT J AU Salice, CJ Suski, JG Bazar, MA Talent, LG AF Salice, Christopher J. Suski, Jamie G. Bazar, Matthew A. Talent, Larry G. TI Effects of inorganic lead on Western fence lizards (Sceloporus occidentalis) SO ENVIRONMENTAL POLLUTION LA English DT Article DE Reptiles; Lizard; Lead; Toxicity; Metals ID SOIL INGESTION; ORAL-EXPOSURE; ECOTOXICOLOGY; TOXICITY; MATURATION; REPTILES; MODELS AB Although anthropogenic pollutants are thought to threaten reptilian species, there are few toxicity studies on reptiles. We evaluated the toxicity of Pb as lead acetate to the Western fence lizard (Sceloporus occidentalis). The acute lethal dose and sub-acute (14-day) toxicity studies were used to narrow exposure concentrations for a sub-chronic (60-day) study. In the sub-chronic study, adult and juvenile male lizards were dosed via gavage with 0, 1, 10 and 20 mg Pb/kg-bw/day. Mortality was limited and occurred only at the highest dose (20 mg Pb/kg-bw/d). There were statistically significant sub-lethal effects of 10 and 20 mg Pb/kg-bw/d on body weight, cricket consumption, organ weight, hematological parameters and post-dose behaviors. Of these, Pb-induced changes in body weight are most useful for ecological risk assessment because it is linked to fitness in wild lizard populations. The Western fence lizard is a useful model for reptilian toxicity studies. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Salice, Christopher J.; Suski, Jamie G.; Bazar, Matthew A.] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. [Talent, Larry G.] Oklahoma State Univ, Dept Nat Resource Ecol & Management, Stillwater, OK 74078 USA. RP Salice, CJ (reprint author), Texas Tech Univ, Inst Environm & Human Hlth, Box 41163, Lubbock, TX 79409 USA. EM chris.salice@ttu.edu; jamie.suski@ttu.edu; matthew.bazar@us.army.mil; larry.talent@okstate.edu NR 26 TC 9 Z9 12 U1 0 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0269-7491 J9 ENVIRON POLLUT JI Environ. Pollut. PD DEC PY 2009 VL 157 IS 12 BP 3457 EP 3464 DI 10.1016/j.envpol.2009.06.013 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA 526ZE UT WOS:000272334500037 PM 19631431 ER PT J AU Klemcke, HG Ryan, KL Britton, SL Koch, LG Dubick, MA Convertino, VA AF Klemcke, Harold G. Ryan, Kathy L. Britton, Steven L. Koch, Lauren G. Dubick, Michael A. Convertino, Victor A. TI Rat Strains Bred for Low and High Aerobic Running Capacity Do Not Differ in Their Survival Time to Hemorrhage SO EXPERIMENTAL BIOLOGY AND MEDICINE LA English DT Article DE aerobic capacity rats; hemorrhagic shock; differential survival ID BODY NEGATIVE-PRESSURE; ARTIFICIAL SELECTION; METABOLIC ACIDEMIA; OXYGEN DEBT; SHOCK; ENDURANCE; INJURY; HYPOTENSION; PREDICTORS; TOLERANCE AB Hemorrhagic shock reflects low tissue perfusion that is inadequate to maintain normal metabolic functions. Often associated with this condition are impairments in cellular oxygen delivery and utilization. Rat strains divergent in their running endurance have been artificially selected over 12 generations. As these rats bred for high (HCR) vs low (LCR) aerobic running capacity have greater tissue O-2 utilization capacity and improved cardiovascular function, we hypothesized that HCR would be more tolerant (i.e., have greater survivability) to the global ischemia of hemorrhagic shock than LCR. To address this hypothesis, survival time to a severe-as substantiated by dramatic changes in plasma lactate, HCO3, and base deficit-controlled hemorrhage was measured. Male rats were catheterized and, similar to 24 h later, an estimated >35% of the calculated blood volume was removed during a 26-min period while the rats were conscious and unrestrained. Rats were observed for 6 h or until death. Contrary to our hypothesis, survival time in HCR (220 +/- 63 min; n = 6) did not differ statistically (P = 0.46) from that in LCR (279 +/- 53 min; n = 7). Similarly, there were no statistical differences (P >= 0.08) between rat lines in blood pH, lactate, HCO3, and base deficit pre- or post-hemorrhage. In addition, few significant differences between lines in response to hemorrhage were detected by measures of cellular antioxidant status in heart, liver, or lung. Since animals with genetically greater tissue oxygen utilization capacity failed to show longer survival times, our results suggest that other mechanisms must play a more dominant role in determining survivability to hemorrhage under conditions of this hemorrhage. C1 [Klemcke, Harold G.; Ryan, Kathy L.; Dubick, Michael A.; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Britton, Steven L.; Koch, Lauren G.] Univ Michigan, Dept Phys Med & Rehabil, Ann Arbor, MI 48109 USA. RP Klemcke, HG (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM harold.klemcke@amedd.army.mil RI Koch, Lauren/D-1258-2010 FU Defense Advanced Research Projects Agency (DARPA); National Center for Research Resources of the National Institutes of Health [RR 17718]; United States Department of Health and Human Services FX This work was supported in part by funds associated with the surviving Blood Loss Program of the Defense Advanced Research Projects Agency (DARPA) and by grant RR 17718 from the National Center for Research Resources of the National Institutes of Health, United States Department of Health and Human Services. NR 40 TC 2 Z9 2 U1 0 U2 0 PU ROYAL SOC MEDICINE PRESS LTD PI LONDON PA 1 WIMPOLE STREET, LONDON W1G 0AE, ENGLAND SN 1535-3702 J9 EXP BIOL MED JI Exp. Biol. Med. PD DEC PY 2009 VL 234 IS 12 BP 1503 EP 1510 DI 10.3181/0812-RM-355 PG 8 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 536BY UT WOS:000273018400012 PM 19657068 ER PT J AU Owens, AT Tippur, HV AF Owens, A. T. Tippur, H. V. TI A Tensile Split Hopkinson Bar for Testing Particulate Polymer Composites Under Elevated Rates of Loading SO EXPERIMENTAL MECHANICS LA English DT Article DE Particulate composites; Tensile stress-strain response; High-strain rate failure; Microstructural effects; Split Hopkinson bar ID EPOXY SYNTACTIC FOAM; SPHERICAL INCLUSIONS; STRAIN; COMPRESSION; STRENGTH; BEHAVIOR; FILLERS; IMPACT; RESIN; SIZE AB A tensile split Hopkinson bar apparatus is developed for testing high strain rate behavior of glass-filled epoxy. The apparatus uses a specimen gripping configuration which does not require fastening and/or gluing and can be readily used for castable materials. Details of the experimental setup, design of grips and specimen, specimen preparation method, benchmark experiments, and tensile responses are reported. Also, the effects of filler volume fraction (0-30%) and particle size (11-42 mu m) are examined under high rates of loading and the results are compared with the ones obtained from quasi-static loading conditions. The results indicate that the increase in the loading rate contributes to a stiffer and brittle material response. In the dynamic case lower ultimate stresses are seen with higher volume fractions of filler whereas in the corresponding quasi-static cases an opposite trend exists. However, the absorbed specific energy values show a decreasing trend in both situations. The results are also evaluated relative to the existing micromechanical models. The tensile response for different filler sizes at a constant volume fraction (10%) is also reported. Larger size filler particles cause a reduction in specimen failure stress and specific energy absorbed under elevated rates of loading. In the quasi-static case, however, the ultimate stress is minimally affected by the filler size. C1 [Owens, A. T.; Tippur, H. V.] Auburn Univ, Dept Mech Engn, Auburn, AL 36849 USA. [Owens, A. T.] USA, RDECOM, AMRDEC, Redstone Arsenal, AL USA. RP Tippur, HV (reprint author), Auburn Univ, Dept Mech Engn, Auburn, AL 36849 USA. EM htippur@eng.auburn.edu NR 24 TC 7 Z9 8 U1 1 U2 10 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0014-4851 EI 1741-2765 J9 EXP MECH JI Exp. Mech. PD DEC PY 2009 VL 49 IS 6 BP 799 EP 811 DI 10.1007/s11340-008-9192-7 PG 13 WC Materials Science, Multidisciplinary; Mechanics; Materials Science, Characterization & Testing SC Materials Science; Mechanics GA 522VZ UT WOS:000272029500004 ER PT J AU Kaminski, RW Oaks, EV AF Kaminski, Robert W. Oaks, Edwin V. TI Inactivated and subunit vaccines to prevent shigellosis SO EXPERT REVIEW OF VACCINES LA English DT Review DE lipopolysaccharide; Ipa; LPS; Shigella; subunit vaccines ID O-SPECIFIC POLYSACCHARIDE; III SECRETION APPARATUS; INVASION PLASMID ANTIGENS; EARLY-CHILDHOOD DIARRHEA; ORAL CHOLERA VACCINE; FLEXNERI 2A; CONJUGATE VACCINES; PROTECTIVE EFFICACY; RIBOSOMAL VACCINE; IMMUNE-RESPONSES AB Shigellosis remains a formidable disease globally, with children of the developing world bearing the greatest number of infections. The need for an affordable, safe and efficacious vaccine has persisted for decades. Vaccines to prevent shigellosis can be divided into living and nonliving approaches. Several nonliving Shigella vaccines are currently at different stages of development and show substantial promise. Outlined here is an overview of multiple nonliving vaccine technologies, highlighting their current status and recent advances in testing. In addition, gaps in the knowledge base regarding immune mechanisms of protection are explored. C1 [Kaminski, Robert W.; Oaks, Edwin V.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. RP Oaks, EV (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, 503 Robert Grant Ave,Room 3A21, Silver Spring, MD 20910 USA. EM edwin.oaks@amedd.army.mil NR 131 TC 36 Z9 36 U1 0 U2 2 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1476-0584 J9 EXPERT REV VACCINES JI Expert Rev. Vaccines PD DEC PY 2009 VL 8 IS 12 BP 1693 EP 1704 DI 10.1586/ERV.09.127 PG 12 WC Immunology SC Immunology GA 531NL UT WOS:000272673900015 PM 19943764 ER PT J AU Dupuy, LC Schmaljohn, CS AF Dupuy, Lesley C. Schmaljohn, Connie S. TI DNA vaccines for biodefense SO EXPERT REVIEW OF VACCINES LA English DT Review DE alphavirus; anthrax; Bacillus anthracis; biodefense; DNA vaccine; Ebola virus; electroporation; gene gun; Marburg virus; monkeypox virus; poxvirus; smallpox; vaccinia virus; variola virus; Venezuelan equine encephalitis virus ID EQUINE ENCEPHALITIS-VIRUS; ANTHRAX PROTECTIVE ANTIGEN; INTRANASAL POXVIRUS CHALLENGE; ADENOVIRUS-BASED VACCINE; EBOLA-VIRUS; BACILLUS-ANTHRACIS; NONHUMAN-PRIMATES; MARBURG VIRUS; HEMORRHAGIC-FEVER; LETHAL FACTOR AB An ideal biodefense vaccine platform would allow for the quick formulation of novel vaccines in response to emerging or engineered pathogens. The resultant vaccine should elicit protective immune responses in one to three doses and be unaffected by pre-existing immunity to vaccine components. In addition, it should be amenable to combination and multi-agent formulation, and should be safe for all populations and the environment. DNA vaccines can potentially meet all of these requirements; thus, this platform is being tested with several biodefense threats. Here, we provide a review of the current status of the development efforts for DNA vaccines against several relevant biodefense pathogens: Bacillus anthracis, Ebola and Marburg viruses, smallpox virus, and Venezuelan equine encephalitis virus. C1 [Schmaljohn, Connie S.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. RP Schmaljohn, CS (reprint author), USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. EM lesley.dupuy@amedd.army.mil; connie.schmaljohn@amedd.army.mil NR 76 TC 15 Z9 17 U1 0 U2 7 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1476-0584 J9 EXPERT REV VACCINES JI Expert Rev. Vaccines PD DEC PY 2009 VL 8 IS 12 BP 1739 EP 1754 DI 10.1586/ERV.09.132 PG 16 WC Immunology SC Immunology GA 531NL UT WOS:000272673900018 PM 19943766 ER PT J AU Karl, JP Alemany, JA Koenig, C Kraemer, WJ Frystyk, J Flyvbjerg, A Young, AJ Nindl, BC AF Karl, J. Philip Alemany, Joseph A. Koenig, Chad Kraemer, William J. Frystyk, Jan Flyvbjerg, Allan Young, Andrew J. Nindl, Bradley C. TI Diet, body composition, and physical fitness influences on IGF-I bioactivity in women SO GROWTH HORMONE & IGF RESEARCH LA English DT Article DE Kinase receptor activation; Bioactive IGF-I; Diet; Fitness; Body composition ID GROWTH-FACTOR-I; POSTMENOPAUSAL WOMEN; BINDING PROTEIN-3; MENSTRUAL-CYCLE; SOY ISOFLAVONES; FACTOR (IGF)-I; HUMAN SERUM; HORMONE; MEN; SYSTEM AB Objective: Insulin-like growth factor I (IGF-I) is a metabolic-regulatory hormone that mediates a variety of physiologic functions. Body composition, fitness status and intake of certain micro- and macronutrients are associated with circulating concentrations of immunoreactive IGF-I. The influence of these factors on IGF-I bioactivity: however, is undetermined. We assessed the relationships between IGF-I bioactivity and lifestyle factors purportedly associated with IGF-I immunoreactivity. Design: In a cross sectional study, fasted blood samples were obtained from 44 lightly active, college-age (20 +/- 2 yrs) women. IGF-I bioactivity was estimated by an assay which determines the ability of serum IGFs to phosphorylate IGF-I receptors in cultured cells; free and total IGF-I were measured by immunoassay. Estradiol and progesterone were measured by immunoassay. Body mass index was calculated from measured height and weight, bone mineral density and body fat percentage measured by dual energy Xray absorptiometry, and peak oxygen consumption (VO2peak) determined during a graded treadmill protocol. A food frequency questionnaire measured habitual and a 5-day food record assessed short-term micro- and macronutrient intakes. Associations between bioactive, free and total IGF-I with body composition, sex hormones, VO2peak, and dietary intake were assessed using univariate and multiple linear regression analyses. Results: Associations between bioactive IGF-I with age (r = -0.36, P < 0.05), body fat percentage (r = -0.32, P < 0.05), estradiol (r = 0.31, P < 0.05) and progesterone (r = 0.33, P < 0.05) concentrations, habitual alcohol (r = -0.38, P < 0.05) and selenium intakes (r = 0.41, P < 0.01), free IGF-I with age (r = -0.34, P < 0.05), estradiol (r = 0.48, P < 0.01) and progesterone (r = 0.52, P < 0.001) concentrations, habitual alcohol (r = -0.33, P < 0.05) and isoflavone intakes (r = 0.30, P < 0.05) and total IGF-I with age (r = -0.27, P < 0.05) and habitual alcohol intake (r = -0.33, P < 0.05) were observed. Habitual alcohol intake was a negative predictor of bioactive, free and total IGF-I in multivariate models. Conclusion: Of the lifestyle factors measured, the most robust relationship observed was a negative association between habitual alcohol intake and all measures of IGF-I. This finding Suggests that alcohol intake may blunt the physiologic actions of the IGF-I axis. Published by Elsevier Ltd. C1 [Karl, J. Philip; Alemany, Joseph A.; Koenig, Chad; Young, Andrew J.; Nindl, Bradley C.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Kraemer, William J.] Univ Connecticut, Dept Kinesiol, Human Performance Lab, Unit 1110, Storrs, CT 06269 USA. [Frystyk, Jan; Flyvbjerg, Allan] Aarhus Univ Hosp, Med Res Labs, Inst Clin, DK-8000 Aarhus, Denmark. [Frystyk, Jan; Flyvbjerg, Allan] Aarhus Univ Hosp, Med Dept Diabet & Endocrinol M, DK-8000 Aarhus, Denmark. RP Nindl, BC (reprint author), USA, Environm Med Res Inst, 42 Kansas St, Natick, MA 01760 USA. EM bradley.nindl@us.army.mil OI Karl, J. Philip/0000-0002-5871-2241 FU United States Army Medical Research and Materiel Command; Danish Research Council for Health and Disease; Clinical Institute at Aarhus University FX Research Supported by the United States Army Medical Research and Materiel Command. The authors do not have any conflicts of interest with the funding agencies of this study.; This study was funded by an US Army Medical Research and Materiel Command Bone Health grant to BCN and supported by research grants from the Danish Research Council for Health and Disease, Clinical Institute at Aarhus University. The authors wish to thank Kirsten Nyborg, Joan Hansen and Susanne Sorensen for expert technical assistance in the measurement of IGFs and SPC Jererny Miller for technical assistance in the measurement of sex hormones. NR 31 TC 10 Z9 11 U1 0 U2 3 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1096-6374 EI 1532-2238 J9 GROWTH HORM IGF RES JI Growth Horm. IGF Res. PD DEC PY 2009 VL 19 IS 6 BP 491 EP 496 DI 10.1016/j.ghir.2009.04.001 PG 6 WC Cell Biology; Endocrinology & Metabolism SC Cell Biology; Endocrinology & Metabolism GA 534MR UT WOS:000272902300005 PM 19467892 ER PT J AU Rusnak, JM Smith, LA AF Rusnak, Janice M. Smith, Leonard A. TI Botulinum neurotoxin vaccines Past history and recent developments SO HUMAN VACCINES LA English DT Review DE botulinum toxin vaccines; botulinum neurotoxin vaccines; botulinum toxoids; botulinum toxin recombinant vaccines; botulism ID TOXIN FRAGMENT-C; COMPLETE NUCLEOTIDE-SEQUENCE; HIGH-LEVEL EXPRESSION; AMINO-ACID-SEQUENCE; CLOSTRIDIUM-BOTULINUM; TETANUS TOXIN; PICHIA-PASTORIS; ESCHERICHIA-COLI; IMMUNE-RESPONSES; BINDING DOMAIN AB Botulinum toxin may cause a neuroparalytic illness that may result in respiratory failure and require prolonged mechanical ventilation. As medical resources needed for supportive care of botulism in a bioterrorist event may quickly overwhelm the local healthcare systems, biodefense research efforts have been directed towards the development of a vaccine to prevent botulism. While human botulism has been caused only by toxin serotypes A, B and E (rarely serotype F), all seven known immunologically distinct toxin serotypes (A-G) may potentially cause intoxication in humans from a bioterrorist event. A pentavalent (ABCDE) botulinum toxoid (PBT) has been administered as an investigational new drug (IND) to at-risk individuals for nearly 50 years. Due to declining immunogenicity of the PBT, research efforts have been directed at development of both improved (less local reactogenicity) botulinum toxoids and recombinant vaccines as potential vaccine candidates to replace the PBT. C1 [Rusnak, Janice M.] USAMRIID, Clin Res Management Inc, Special Immunizat Program, Ft Detrick, MD USA. [Smith, Leonard A.] US Army Med Res & Mat Command, Med Countermeasures, Ft Detrick, MD USA. RP Rusnak, JM (reprint author), USAMRIID, Clin Res Management Inc, Special Immunizat Program, Ft Detrick, MD USA. EM Janice.Rusnak@amedd.army.mil NR 120 TC 30 Z9 33 U1 0 U2 11 PU LANDES BIOSCIENCE PI AUSTIN PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA SN 1554-8600 J9 HUM VACCINES JI Hum. Vaccines PD DEC PY 2009 VL 5 IS 12 BP 794 EP 805 PG 12 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA 541LQ UT WOS:000273417600007 PM 19684478 ER PT J AU Chandrahalim, H Bhave, SA Polcawich, RG Pulskamp, J Kaul, R AF Chandrahalim, Hengky Bhave, Sunil A. Polcawich, Ronald G. Pulskamp, Jeff Kaul, Roger TI A Pb(Zr0.55Ti0.45)O-3-Transduced Fully Differential Mechanically Coupled Frequency Agile Filter SO IEEE ELECTRON DEVICE LETTERS LA English DT Article DE Differential; filters; piezoelectric; RF MEMS; voltage tuning ID MODE MEMS RESONATORS AB This letter reports on the performances of a frequency-tunable lead-zirconate-titanate-transduced fully differential mechanically coupled high-overtone width-extensional filter. The demonstrated electric field tuning provides channel agility and bandwidth adjustability for the incorporation of analog spectral processors in modern radio receiver architectures. We designed and experimentally characterized the higher overtone frequency response of a fully differential width-extensional filter. The filter demonstrates a center frequency (f(C)) tuning range of 7 MHz at 260 MHz and an adjustable bandwidth from 3 to 6.3 MHz while maintaining a maximum frequency shift due to hysteresis effects below 0.14% and a stopband rejection floor of -60 dB. C1 [Chandrahalim, Hengky; Bhave, Sunil A.] Cornell Univ, Dept Elect & Comp Engn, Ithaca, NY 14853 USA. [Polcawich, Ronald G.; Pulskamp, Jeff; Kaul, Roger] USA, Res Lab, Adelphi, MD 20783 USA. RP Chandrahalim, H (reprint author), Cornell Univ, Dept Elect & Comp Engn, Ithaca, NY 14853 USA. EM hc287@cornell.edu; sunil@ece.cornell.edu; rpolcawich@arl.army.mil; jeffrey.pulskamp1@us.army.mil; roger.kaul@us.army.mil RI Chandrahalim, Hengky/F-1475-2016 OI Chandrahalim, Hengky/0000-0003-1930-1359 NR 12 TC 2 Z9 2 U1 2 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0741-3106 J9 IEEE ELECTR DEVICE L JI IEEE Electron Device Lett. PD DEC PY 2009 VL 30 IS 12 BP 1296 EP 1298 DI 10.1109/LED.2009.2034112 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA 523BB UT WOS:000272044500016 ER PT J AU Culbert, PD Pidgeon, AM St-Louis, V Bash, D Radeloff, VC AF Culbert, Patrick D. Pidgeon, Anna M. St-Louis, Veronique Bash, Dallas Radeloff, Volker C. TI The Impact of Phenological Variation on Texture Measures of Remotely Sensed Imagery SO IEEE JOURNAL OF SELECTED TOPICS IN APPLIED EARTH OBSERVATIONS AND REMOTE SENSING LA English DT Article DE Image texture analysis; remote sensing; vegetation ID SATELLITE IMAGERY; FOREST STRUCTURE; MONITORING VEGETATION; SPECIES COMPOSITION; HABITAT SELECTION; CLASSIFICATION; INFORMATION; FEATURES; STATES; AREA AB Measures of image texture derived from remotely sensed imagery have proven useful in many applications. However, when using multitemporal imagery or multiple images to cover a large study area, it is important to understand how image texture measures are affected by surface phenology. Our goal was to characterize the robustness to phenological variation of common first- and second-order texture measures of satellite imagery. Three North American study sites were chosen to represent different biomes. At each site, a suite of image textures were calculated for three to four dates across the growing season. Texture measures were compared among dates to quantify their stability, and the stability of measures was also compared between biomes. Interseasonal variability of texture measures was high overall (mean interseasonal coefficient of variation = 0.79), indicating that care must be taken when using measures of texture at different phenological stages. Certain texture measures, such as first- order mean and entropy, as well as second-order homogeneity, entropy, and dissimilarity, were more robust to phenological change than other measures. C1 [Culbert, Patrick D.; Pidgeon, Anna M.; St-Louis, Veronique; Radeloff, Volker C.] Univ Wisconsin, Dept Forest & Wildlife Ecol, Madison, WI 53706 USA. [Bash, Dallas] Directorate Environm, Ft Bliss, TX 79916 USA. RP Culbert, PD (reprint author), Univ Wisconsin, Dept Forest & Wildlife Ecol, Madison, WI 53706 USA. EM pdculbert@wisc.edu RI Radeloff, Volker/B-6124-2016 OI Radeloff, Volker/0000-0001-9004-221X FU National Aeronautics and Space Administration Biodiversity Program [NNG06GJ00G]; Strategic Environmental Research and Development Program FX Manuscript received November 07, 2008; revised March 23, 2009. First published May 19, 2009; current version published January 20, 2010. This work was supported in part by the National Aeronautics and Space Administration Biodiversity Program under Grant NNG06GJ00G and in part by the Strategic Environmental Research and Development Program. NR 38 TC 15 Z9 16 U1 1 U2 16 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1939-1404 J9 IEEE J-STARS JI IEEE J. Sel. Top. Appl. Earth Observ. Remote Sens. PD DEC PY 2009 VL 2 IS 4 BP 299 EP 309 DI 10.1109/JSTARS.2009.2021959 PG 11 WC Engineering, Electrical & Electronic; Geography, Physical; Remote Sensing; Imaging Science & Photographic Technology SC Engineering; Physical Geography; Remote Sensing; Imaging Science & Photographic Technology GA 546BY UT WOS:000273784400010 ER PT J AU Ding, HP Chen, G Majumdar, AK Sadler, BM Xu, ZY AF Ding, Haipeng Chen, Gang Majumdar, Arun K. Sadler, Brian M. Xu, Zhengyuan TI Modeling of Non-Line-of-Sight Ultraviolet Scattering Channels for Communication SO IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS LA English DT Article DE Multiple scattering; non-line-of-sight; ultraviolet; Monte Carlo; photon tracing ID LIGHT-EMITTING-DIODES; AVALANCHE PHOTODIODES; PERFORMANCE; ATMOSPHERE; AUREOLE AB A stochastic non-line-of-sight (NLOS) ultraviolet (UV) communication channel model is developed using a Monte Carlo simulation method based on photon tracing. The expected channel impulse response is obtained by computing photon arrival probabilities and associated propagation delay at the receiver. This method captures the multiple scattering effects of UV signal propagation in the atmosphere, and relaxes the assumptions of single scattering theory. The proposed model has a clear advantage in reliable prediction of NLOS path loss, as validated by outdoor experiments at small to medium elevation angles. A Gamma function is shown to agree well with the predicted impulse response, and this provides a simple means to determine the channel bandwidth. The developed model is employed to study the characteristics of NLOS UV scattering channels, including path loss and channel bandwidth, for a variety of scattering conditions, source wavelength, transmitter and receiver optical pointing geometries, and range. C1 [Ding, Haipeng; Chen, Gang; Xu, Zhengyuan] Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. [Majumdar, Arun K.] USN, Air Warfare Ctr, Weap Div, China Lake, CA 93555 USA. [Sadler, Brian M.] USA, Res Lab, RDRL CIN T, Adelphi, MD 20783 USA. RP Ding, HP (reprint author), Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. EM arun.majumdar@navy.mil; bsadler@arl.army.mil; dxu@ee.ucr.edu RI Ding, Haipeng/B-7742-2014 FU Army Research Office [W911NF-06-1-0364, W911NF-06-1-0173]; Army Research Laboratory [DAAD19-01-2-0011] FX This work was supported in part by the Army Research Office under Grants W911NF-06-1-0364 and W911NF-06-1-0173, and the Army Research Laboratory under the Collaborative Technology Alliance Program, Cooperative Agreement DAAD19-01-2-0011. NR 32 TC 99 Z9 112 U1 2 U2 12 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0733-8716 J9 IEEE J SEL AREA COMM JI IEEE J. Sel. Areas Commun. PD DEC PY 2009 VL 27 IS 9 BP 1535 EP 1544 DI 10.1109/JSAC.2009.091203 PG 10 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 526SX UT WOS:000272315200003 ER PT J AU Qiu, JX Levush, B Pasour, J Katz, A Armstrong, CM Whaley, DR Tucek, J Kreischer, K Gallagher, D AF Qiu, Joe X. Levush, Baruch Pasour, John Katz, Allen Armstrong, Carter M. Whaley, David R. Tucek, Jack Kreischer, Kenneth Gallagher, David TI Vacuum Tube Amplifiers SO IEEE MICROWAVE MAGAZINE LA English DT Article ID TRAVELING-WAVE TUBES; MICROWAVE-POWER MODULE; PERFORMANCE; STABILITY; CATHODE; DESIGN C1 [Qiu, Joe X.] Army Res Lab, Adelphi, MD 20783 USA. [Levush, Baruch; Pasour, John] USN, Res Lab, Washington, DC 20375 USA. [Katz, Allen] Coll New Jersey, Elect & Comp Engn Dept, Ewing, NJ USA. [Katz, Allen] Linearizer Technol Inc, Hamilton, NJ 08619 USA. [Armstrong, Carter M.; Whaley, David R.] Electron Devices Div, San Carlos, CA 94070 USA. [Tucek, Jack; Kreischer, Kenneth; Gallagher, David] Northrop Grumman Corp, Rolling Meadows, IL 60008 USA. RP Qiu, JX (reprint author), Army Res Lab, Adelphi, MD 20783 USA. EM joe.qiu@arl.army.mil RI Vage, Lars/D-2602-2010 NR 47 TC 39 Z9 43 U1 5 U2 21 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1527-3342 EI 1557-9581 J9 IEEE MICROW MAG JI IEEE Microw. Mag. PD DEC PY 2009 VL 10 IS 7 BP 38 EP 51 DI 10.1109/MMM.2009.934517 PG 14 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 521VP UT WOS:000271953200005 ER PT J AU Liao, DH Sarabandi, K AF Liao, DaHan Sarabandi, Kamal TI Simulation of Near-Ground Long-Distance Radiowave Propagation Over Terrain Using Nystrom Method With Phase Extraction Technique and FMM-Acceleration SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Article DE Fast multipole method (FMM); integral equation method; near-ground propagation; numerical simulation; Nystrom method; phase extraction ID TABULATED INTERACTION METHOD; IRREGULAR TERRAIN; SCATTERING; FORMULATION; EQUATION; BODIES AB A 2D surface integral equation-based Nystrom solver in which a phase extraction technique is utilized to reduce the number of surface unknowns is described. As forward scattering is the dominant mechanism for the near-ground wave propagation scenario, the associated rapidly-varying phase components of the integral equation kernel and solution unknowns are deduced and isolated in advance and subsequently built into the solver. It is shown that by applying this method, when combining with an adaptive surface segmentation routine, as few as one to two average unknowns per wavelength is adequate in obtaining accurate solutions. This significantly reduces the memory storage and computational expense for the simulation of long-distance propagation effects. The efficiency of this method is further improved by incorporating it into the framework of the fast multipole scheme. The full details of the algorithm are discussed, along with performance comparisons of the new solver to a regular Nystrom solver for terrain surfaces in terms of solution convergence. C1 [Liao, DaHan; Sarabandi, Kamal] Univ Michigan, Radiat Lab, Dept Elect Engn & Comp Sci, Ann Arbor, MI 48109 USA. RP Liao, DH (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM liaod@umich.edu NR 19 TC 7 Z9 7 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-926X J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD DEC PY 2009 VL 57 IS 12 BP 3882 EP 3890 DI 10.1109/TAP.2009.2033483 PG 9 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 526SK UT WOS:000272313500026 ER PT J AU Li, M Batalama, SN Pados, DA Matyjas, JD AF Li, Ming Batalama, Stella N. Pados, Dimitris A. Matyjas, John D. TI Minimum Total-Squared-Correlation Quaternary Signature Sets: New Bounds and Optimal Designs SO IEEE TRANSACTIONS ON COMMUNICATIONS LA English DT Article DE Code-division multiplexing; multiuser communications; quadriphase symbols; quaternary alphabet; sequences; sum capacity; Welch bound ID SYNCHRONOUS CDMA SYSTEMS; KARYSTINOS-PADOS BOUNDS; SUM CAPACITY; DS-CDMA; INTERFERENCE AVOIDANCE; OPTIMAL SEQUENCES; WIRELESS SYSTEMS; UNITARY MATRICES; PARAMETRIZATION; CHANNELS AB We derive new bounds on the total squared correlation (TSC) of quaternary (quadriphase) signature/sequence sets for all lengths L and set sizes K Then, for all K, L, we design minimum-TSC optimal sets that meet the new bounds with equality. Direct numerical comparison with the TSC value of the recently obtained optimal binary sets shows under what K, L realizations gains are materialized by moving from the binary to the quaternary code-division multiplexing alphabet. On the other hand, comparison with the Welch TSC value for real/complex-field sets shows that, arguably, not much is to be gained by raising the alphabet size above four for any K, L. The sum-capacity (as well as the maximum squared correlation and total asymptotic efficiency) of minimum TSC quaternary sets is also evaluated in closed-form and contrasted against the sum capacity of minimum-TSC optimal binary and real/complex sets. C1 [Li, Ming; Batalama, Stella N.; Pados, Dimitris A.] SUNY Buffalo, Dept Elect Engn, Buffalo, NY 14260 USA. [Matyjas, John D.] USA, Res Lab, RIGE, Rome, NY 13441 USA. RP Li, M (reprint author), SUNY Buffalo, Dept Elect Engn, Buffalo, NY 14260 USA. EM mingli@eng.buffalo.edu; batalama@eng.buffalo.edu; pados@eng.buffalo.edu; John.Matyjas@rl.af.mil FU U.S. Air Force Research Laboratory [FA8750-08-1-0063] FX This work was supported by the U.S. Air Force Research Laboratory under Grant FA8750-08-1-0063. Material from this paper was presented at the 2009 European Signal Processing Conference (EUSIPCO), Glasgow, Scotland, and the 2009 IEEE Global Communications Conference (GLOBECOM), Honolulu, Hawaii. NR 30 TC 6 Z9 6 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0090-6778 EI 1558-0857 J9 IEEE T COMMUN JI IEEE Trans. Commun. PD DEC PY 2009 VL 57 IS 12 BP 3662 EP 3671 DI 10.1109/TCOMM.2009.12.080589 PG 10 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 532CG UT WOS:000272721000023 ER PT J AU Darwish, AM Huebschman, BD Viveiros, E Hung, HA AF Darwish, Ali M. Huebschman, Benjamin D. Viveiros, Edward Hung, H. Alfred TI Dependence of GaN HEMT Millimeter-Wave Performance on Temperature SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Article DE Aluminum-gallium-nitride (AlGaN); gallium-nitride (GaN); high electron-mobility transistor (HEMT); millimeter wave; reliability; thermal resistance; wide bandgap ID ALGAN/GAN HEMT; POWER; TRANSISTORS; VELOCITY AB This paper presents extensive thermal characterization of recently fabricated high-performance millimeter-wave GaN/SiC devices from four sources across temperature (-25 degrees C to +125 degrees C). The changes with temperature for: output power at millimeter-wave frequencies (P(out)), pinchoff voltage (V(p)), knee-voltage (V(k)), onresistance (R(on)), power-added efficiency (PAE), saturated drain current (I(dss)), power gain (G), and transconductance (g(m)) are measured, statistics studied, and correlations investigated. Temperature-coefficients are established for P(out), V(p), V(k), R(on), PAE, I(dss), G, and g(m) in GaN technology. The main findings are: 1) P(out)'s temperature dependence can be negative or positive, opposite of G's and I(dss)'s strong negative temperature dependence, and 2) the pinchoff voltage's dependence on temperature is very weak. The results obtained provide monolithic microwave integrated circuit designers with key information required for meeting performance over a wide temperature range. C1 [Darwish, Ali M.] Amer Univ Cairo, New Cairo 11835, Egypt. [Huebschman, Benjamin D.; Viveiros, Edward; Hung, H. Alfred] USA, Res Lab, Adelphi, MD 20783 USA. RP Darwish, AM (reprint author), Amer Univ Cairo, New Cairo 11835, Egypt. EM darwish@alum.mit.edu; hahung@alum.mit.edu NR 15 TC 18 Z9 19 U1 1 U2 10 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9480 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD DEC PY 2009 VL 57 IS 12 BP 3205 EP 3211 DI 10.1109/TMTT.2009.2034050 PG 7 WC Engineering, Electrical & Electronic SC Engineering GA 530PD UT WOS:000272603900019 ER PT J AU Gadlage, MJ Ahlbin, JR Ramachandran, V Gouker, P Dinkins, CA Bhuva, BL Narasimham, B Schrimpf, RD McCurdy, MW Alles, ML Reed, RA Mendenhall, MH Massengill, LW Shuler, RL McMorrow, D AF Gadlage, Matthew J. Ahlbin, Jonathan R. Ramachandran, Vishwanath Gouker, Pascale Dinkins, Cody A. Bhuva, Bharat L. Narasimham, Balaji Schrimpf, Ronald D. McCurdy, Michael W. Alles, Michael L. Reed, Robert A. Mendenhall, Marcus H. Massengill, Lloyd W. Shuler, Robert L. McMorrow, Dale TI Temperature Dependence of Digital Single-Event Transients in Bulk and Fully-Depleted SOI Technologies SO IEEE TRANSACTIONS ON NUCLEAR SCIENCE LA English DT Article; Proceedings Paper CT 46th Annual IEEE International Nuclear and Space Radiation Effects Conference CY JUL 20-24, 2009 CL Quebec City, CANADA SP IEEE DE Heavy ions; ion radiation effects; silicon-on-insulator technology; single event upset (SEU); single event transients ID HEAVY-ION; WELL CONTACTS; PULSE-WIDTHS; CMOS; PROPAGATION; LOGIC AB Factors that affect single-event transient pulse widths, such as drift, diffusion, and parasitic bipolar transistor parameters, are also strong functions of operating temperature. In this paper, SET pulse-width measurements are performed over a wide temperature range in both bulk and fully-depleted SOI (silicon on insulator) technologies. The average pulse-width increases with temperature for the bulk process, but not for the FDSOI process. C1 [Gadlage, Matthew J.; Ahlbin, Jonathan R.; Ramachandran, Vishwanath; Dinkins, Cody A.; Bhuva, Bharat L.; Schrimpf, Ronald D.; McCurdy, Michael W.; Alles, Michael L.; Reed, Robert A.; Mendenhall, Marcus H.; Massengill, Lloyd W.] Vanderbilt Univ, Nashville, TN 37212 USA. [Gouker, Pascale] MIT, Lincoln Lab, Lexington, MA 02420 USA. [Narasimham, Balaji] Broadcom Inc, Irvine, CA 92617 USA. [Shuler, Robert L.] NASA, Lyndon B Johnson Space Ctr, Houston, TX 77058 USA. [McMorrow, Dale] USA, Res Lab, Washington, DC 20375 USA. RP Gadlage, MJ (reprint author), Vanderbilt Univ, Nashville, TN 37212 USA. EM matthew.j.gadlage@vanderbilt.edu; jon.ahlbin@van-derbilt.edu; vishwa.ramachandran@vanderbilt.edu; pgouker@ll.mit.edu; cody.a.dinkins@vander-bilt.edu; bharat.bhuva@vanderbilt.edu; bal-ajin@broadcom.com; ron.schrimpf@vanderbilt.edu; mike.mccurdy@vanderbilt.edu; mike.alles@vanderbilt.edu; robert.reed@vander-bilt.edu; marcus.h.mendenhall@vanderbilt.edu; lloyd.massengill@vanderbilt.edu; robert.l.shuler@nasa.gov; mcmorrow@ccs.nrl.navy.mil RI Schrimpf, Ronald/L-5549-2013 OI Schrimpf, Ronald/0000-0001-7419-2701 NR 15 TC 16 Z9 18 U1 1 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9499 J9 IEEE T NUCL SCI JI IEEE Trans. Nucl. Sci. PD DEC PY 2009 VL 56 IS 6 BP 3115 EP 3121 DI 10.1109/TNS.2009.2034150 PG 7 WC Engineering, Electrical & Electronic; Nuclear Science & Technology SC Engineering; Nuclear Science & Technology GA 530PN UT WOS:000272604900016 ER PT J AU Moran, JT McClory, JW Petrosky, JC Farlow, GC AF Moran, Jeffrey T. McClory, John W. Petrosky, James C. Farlow, Gary C. TI The Effects of Temperature and Electron Radiation on the Electrical Properties of AlGaN/GaN HFETs SO IEEE TRANSACTIONS ON NUCLEAR SCIENCE LA English DT Article; Proceedings Paper CT 46th Annual IEEE International Nuclear and Space Radiation Effects Conference CY JUL 20-24, 2009 CL Quebec City, CANADA SP IEEE DE Electron irradiation; gallium nitride; heterojunction field effect transistors ID MOBILITY TRANSISTORS; PROTON; DEVICES AB Al(0.27)Ga(0.73)N/GaN HFETs were electron irradiated at 80 K. The gate leakage and transistor current were measured and compared to theoretical tunneling models. The results are consistent with previous work but explicitly show that radiation produces point defects in the AlGaN that are positively charged at low temperature. C1 [Moran, Jeffrey T.] USA, Kirtland AFB, NM 87117 USA. [Moran, Jeffrey T.] DTRA RD CXT, Def Threat Reduct Agcy, Kirtland AFB, NM 87117 USA. [McClory, John W.] USA, Wright Patterson AFB, OH 45433 USA. [McClory, John W.; Petrosky, James C.] AF Inst Technol, Wright Patterson AFB, OH 45433 USA. [Farlow, Gary C.] Wright State Univ, Dept Phys, Dayton, OH 45435 USA. RP Moran, JT (reprint author), USA, Kirtland AFB, NM 87117 USA. EM jeffrey.t.moran@us.army.mil; john.mcclory@afit.edu; james.petrosky@afit.edu; gary.farlow@wright.edu OI McClory, John/0000-0002-4303-2729 NR 18 TC 6 Z9 8 U1 2 U2 13 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9499 J9 IEEE T NUCL SCI JI IEEE Trans. Nucl. Sci. PD DEC PY 2009 VL 56 IS 6 BP 3223 EP 3228 DI 10.1109/TNS.2009.2033694 PG 6 WC Engineering, Electrical & Electronic; Nuclear Science & Technology SC Engineering; Nuclear Science & Technology GA 530PN UT WOS:000272604900032 ER PT J AU Zirnheld, JL Olabisi, S Burke, K Disanto, TM Moore, HL Singh, H AF Zirnheld, Jennifer L. Olabisi, Shola Burke, Kevin Disanto, Thomas M. Moore, Harry L., Jr. Singh, Hardev TI Electric Explosion of Aluminum Metallized Film SO IEEE TRANSACTIONS ON PLASMA SCIENCE LA English DT Article DE Aluminum metallized film; exploding film; pulsed power; specific action integral ID ENERGY; WIRES; FOILS AB Two types of capacitor-grade aluminum metallized polypropylene film were studied to investigate the factors that affect specific action integral and energy dissipation in the electrical explosion of a film, a phenomenon that occurs when a film is exposed to a high-density current pulse on the order of 10(7)-10(8) A/cm(2). The factors studied include film cross-sectional area, film length, film sheet resistance, and discharge circuit inductance. All film samples were subjected to a 2.5-kV capacitive discharge. The basic principles of the exploding-film phenomenon and the detailed effects of the stated factors are discussed. C1 [Zirnheld, Jennifer L.] SUNY Buffalo, Dept Elect Engn, Energy Syst Inst, Buffalo, NY 14260 USA. [Moore, Harry L., Jr.; Singh, Hardev] USA, RDECOM ARDEC, Adv Energy Armament Syst Ctr, Bronx, NJ 07806 USA. RP Zirnheld, JL (reprint author), SUNY Buffalo, Dept Elect Engn, Energy Syst Inst, Buffalo, NY 14260 USA. EM zirnheld@eng.buffalo.edu; solabisi@buffalo.edu; kmburke@eng.buffalo.edu; tdisanto@buffalo.edu; harry.l.moore@us.army.mil; hardev.singh@us.army.mil NR 18 TC 6 Z9 6 U1 0 U2 8 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0093-3813 J9 IEEE T PLASMA SCI JI IEEE Trans. Plasma Sci. PD DEC PY 2009 VL 37 IS 12 BP 2378 EP 2384 DI 10.1109/TPS.2009.2032547 PG 7 WC Physics, Fluids & Plasmas SC Physics GA 530PY UT WOS:000272606000009 ER PT J AU Glen, AG Foote, BL AF Glen, Andrew G. Foote, Bobbie L. TI An Inference Methodology for Life Tests With Complete Samples or Type-II Right Censoring SO IEEE TRANSACTIONS ON RELIABILITY LA English DT Article DE Computational algebra systems; goodness-of-fit; probability integral transform; uniformity testing ID DISCRETE RANDOM-VARIABLES; ORDER-STATISTICS AB We present a methodology for gaining statistical inference during the actual conduct of a life test experiment that can reduce time on test and cost. The method relies on properties of conditional order statistic distributions to convert censored data into i.i.d. uniform variates. A secondary result presents a new test for uniformity based on the convolution of these i.i.d. uniform random variables that is higher in power than the benchmark Anderson-Darling statistic in certain cases. C1 [Glen, Andrew G.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Foote, Bobbie L.] Univ Oklahoma, Sch Ind Engn, Norman, OK 73019 USA. RP Glen, AG (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. NR 17 TC 1 Z9 1 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9529 EI 1558-1721 J9 IEEE T RELIAB JI IEEE Trans. Reliab. PD DEC PY 2009 VL 58 IS 4 BP 597 EP 603 DI 10.1109/TR.2009.2034287 PG 7 WC Computer Science, Hardware & Architecture; Computer Science, Software Engineering; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 526SV UT WOS:000272314800004 ER PT J AU Ghogho, M Ciblat, P Swami, A Bianchi, P AF Ghogho, Mounir Ciblat, Philippe Swami, Ananthram Bianchi, Pascal TI Training Design for Repetitive-Slot-Based CFO Estimation in OFDM SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article DE Acquisition; synchronization; tracking ID FREQUENCY OFFSET ESTIMATOR; FADING CHANNELS AB Carrier frequency offset (CFO) estimation is a key challenge in wireless systems employing orthogonal frequency-division multiplexing (OFDM) modulation. Often, CFO estimation is carried out using a preamble made of a number, say, of repetitive slots (RS). We here focus on the issue of optimal RS preamble design using the Cramer-Rao bound (CRB) averaged over the channel, which is assumed to be Rayleigh. We show that the optimal value of is a tradeoff between the multipath diversity gain and the number of unknowns to be estimated. In the case of correlated channel taps, we also show that uniform power loading of the active subcarriers is not optimal ( in contrast with the uncorrelated case) and better power loading schemes are proposed. The proposed power loading schemes consist of allocating more power to activated carriers with higher signal-to-noise ratios. Simulation-based performance results of the maximum likelihood estimator support the CRB-based theoretical results. C1 [Ghogho, Mounir] Univ Leeds, Sch Elect & Elect Engn, Leeds LS2 9JT, W Yorkshire, England. [Ciblat, Philippe] ENST, Dept Comelec, F-75013 Paris, France. [Swami, Ananthram] Army Res Lab, Adelphi, MD 20783 USA. [Bianchi, Pascal] Supelec, Dept Telecom, F-75013 Paris, France. RP Ghogho, M (reprint author), Univ Leeds, Sch Elect & Elect Engn, Leeds LS2 9JT, W Yorkshire, England. EM m.ghogho@leeds.ac.uk; philippe.ciblat@enst.fr; a.swami@ieee.org; pascal.bianchi@supelec.fr FU The Royal Society FX Manuscript received November 12, 2008; accepted May 02, 2009. First published June 10, 2009; current version published November 18, 2009. The associate editor coordinating the review of this manuscript and approving it for publication was Dr. Anna Scaglione. This work has been supported in part by The Royal Society. This work was presented in part at IEEE Conference on Global Telecommunications ( IEEE Globecom), Washington DC, November 2007. NR 8 TC 7 Z9 7 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1053-587X J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD DEC PY 2009 VL 57 IS 12 BP 4958 EP 4964 DI 10.1109/TSP.2009.2025080 PG 7 WC Engineering, Electrical & Electronic SC Engineering GA 521XB UT WOS:000271958600033 ER PT J AU Barnes, LE Fields, MA Valavanis, KP AF Barnes, Laura E. Fields, Mary Anne Valavanis, Kimon P. TI Swarm Formation Control Utilizing Elliptical Surfaces and Limiting Functions SO IEEE TRANSACTIONS ON SYSTEMS MAN AND CYBERNETICS PART B-CYBERNETICS LA English DT Article DE Formation control; multiagent systems; potential fields; swarms ID NONHOLONOMIC MOBILE ROBOTS; QUEUE-FORMATION SCHEME; MULTIROBOT FORMATIONS; COMMUNICATION; VEHICLES; PATTERNS AB In this paper, we present a strategy for organizing swarms of unmanned vehicles into a formation by utilizing artificial potential fields that were generated from normal and sigmoid functions. These functions construct the surface on which swarm members travel, controlling the overall swarm geometry and the individual member spacing. Nonlinear limiting functions are defined to provide tighter swarm control by modifying and adjusting a set of control variables that force the swarm to behave according to set constraints, formation, and member spacing. The artificial potential functions and limiting functions are combined to control swarm formation, orientation, and swarm movement as a whole. Parameters are chosen based on desired formation and user-defined constraints. This approach is computationally efficient and scales well to different swarm sizes, to heterogeneous systems, and to both centralized and decentralized swarm models. Simulation results are presented for a swarm of 10 and 40 robots that follow circle, ellipse, and wedge formations. Experimental results are included to demonstrate the applicability of the approach on a swarm of four custom-built unmanned ground vehicles (UGVs). C1 [Barnes, Laura E.] Univ Texas Arlington, Automat & Robot Res Inst, Arlington, TX 76019 USA. [Fields, Mary Anne] USA, Res Lab, Vehicle Technol Directorate, Intelligent Control Team,Unmanned Syst Div, Adelphi, MD 20783 USA. [Valavanis, Kimon P.] Univ Denver, Dept Elect & Comp Engn, Denver, CO 80208 USA. RP Barnes, LE (reprint author), Univ Texas Arlington, Automat & Robot Res Inst, Arlington, TX 76019 USA. NR 55 TC 38 Z9 38 U1 3 U2 14 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1083-4419 EI 1941-0492 J9 IEEE T SYST MAN CY B JI IEEE Trans. Syst. Man Cybern. Part B-Cybern. PD DEC PY 2009 VL 39 IS 6 BP 1434 EP 1445 DI 10.1109/TSMCB.2009.2018139 PG 12 WC Automation & Control Systems; Computer Science, Artificial Intelligence; Computer Science, Cybernetics SC Automation & Control Systems; Computer Science GA 498MB UT WOS:000270143800008 PM 19447722 ER PT J AU Chitadze, N Kuchuloria, T Clark, DV Tsertsvadze, E Chokheli, M Tsertsvadze, N Trapaidze, N Lane, A Bakanidze, L Tsanava, S Hepburn, MJ Imnadze, P AF Chitadze, N. Kuchuloria, T. Clark, D. V. Tsertsvadze, E. Chokheli, M. Tsertsvadze, N. Trapaidze, N. Lane, A. Bakanidze, L. Tsanava, S. Hepburn, M. J. Imnadze, P. TI Water-Borne Outbreak of Oropharyngeal and Glandular Tularemia in Georgia: Investigation and Follow-up SO INFECTION LA English DT Article ID FRANCISELLA-TULARENSIS; VACCINE; DISEASE; PCR; CHALLENGE; DIAGNOSIS; RESPONSES; RISK AB Background: In November 2006, an outbreak of water-borne tularemia occurred in an eastern region in the Republic of Georgia. Outbreak investigation revealed 26 cases: 21 oropharyngeal and 5 glandular tularemia cases. Methods: The presentation of the index case triggered an outbreak investigation involving the collection of clinical/epidemiological data, application of tularine skin test, and laboratory confirmation of the possible cases using the tube agglutination test and polymerase chain reaction (PCR) testing. Serology results were verified by enzyme-Linked immunosorbent assay (ELISA) and Western blot. A case-control study along with follow-up was conducted 4 months after the index case presentation. Results: Exudative pharyngitis, predominantly laterocervical adenitis, fever, and headache were the most prevalent clinical signs/symptoms observed. Depressed mood, concentration difficulties, and steep disturbance were also detected. Bubo aspirates tested by PCR were positive in 4/4 cases and pharyngeal swabs also tested by PCR were positive in 2/3 cases. Francisella tularensis was isolated from the water samples. Comparison of the cases and controls did not reveal any statistically significant risk factors. A follow-up investigation revealed cases with protracted symptoms of fatigue, headache, and steep disturbance. Additionally, 8/26 cases still had cervical adenopathy of prominent size. A delay in diagnosis was associated with persistent lymphadenopathy on follow-up examination (p = 0.05). Conclusion: We observed unique features of persistent neuropsychiatric symptoms and lymphadenopathy 5 months after tularemia infection which were associated with delayed diagnosis and the tack of prompt response to therapy. This outbreak of oropharyngeal tularemia emphasizes the importance of a rapid diagnostic and investigative response to tularemia. This type of response can prevent ongoing exposure, as welt as provide expeditious treatment to mitigate persistent symptoms. C1 [Clark, D. V.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Chitadze, N.; Tsertsvadze, E.; Chokheli, M.; Tsertsvadze, N.; Trapaidze, N.; Bakanidze, L.; Tsanava, S.; Imnadze, P.] Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia. [Kuchuloria, T.] Technol Management Co, Tbilisi, Rep of Georgia. [Lane, A.; Hepburn, M. J.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Clark, DV (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. FU US Department of Defense Cooperative Threat Reduction FX Funding for this project was provided by the US Department of Defense Cooperative Threat Reduction Program. implemented by the US Defense Threat Reduction Agency The views of the authors do not purport to reflect the positions of the US Army nor the US Department of Defense. This information was presented in part at the 56th Annual Meeting of the American society of Tropical Medicine and Hygiene (ASTMH). Philadelphia. PA, November 4-8, 2007. abstract #2461 NR 23 TC 21 Z9 21 U1 0 U2 4 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0300-8126 J9 INFECTION JI Infection PD DEC PY 2009 VL 37 IS 6 BP 514 EP 521 DI 10.1007/s15010-009-8193-5 PG 8 WC Infectious Diseases SC Infectious Diseases GA 529YK UT WOS:000272555100005 PM 19826763 ER PT J AU Hilger, H Pust, S von Figura, G Kaiser, E Stiles, BG Popoff, MR Barth, H AF Hilger, Hanna Pust, Sascha von Figura, Guido Kaiser, Eva Stiles, Bradley G. Popoff, Michel R. Barth, Holger TI The Long-Lived Nature of Clostridium perfringens Iota Toxin in Mammalian Cells Induces Delayed Apoptosis SO INFECTION AND IMMUNITY LA English DT Article ID BOTULINUM C2 TOXIN; ADP-RIBOSYLATES ACTIN; BINARY TOXIN; ENZYMATIC COMPONENT; SPIROFORME TOXIN; DIFFICILE; RIBOSYLTRANSFERASE; SPVB; PROTEINS; PURIFICATION AB Mono-ADP ribosylation of actin by bacterial toxins, such as Clostridium perfringens iota or Clostridium botulinum C2 toxins, results in rapid depolymerization of actin filaments and cell rounding. Here we report that treatment of African green monkey kidney (Vero) cells with iota toxin resulted in delayed caspase-dependent death. Unmodified actin did not reappear in toxin-treated cells, and enzyme-active toxin was detectable in the cytosol for at least 24 h. C2 toxin showed comparable, long-lived effects in cells, while a C2 toxin control lacking ADP-ribosyltransferase activity did not induce cell death. To address whether the remarkable stability of the iota and C2 toxins in cytosol was crucial for inducing cell death, we treated cells with C/SpvB, the catalytic domain of Salmonella enterica SpvB. Although C/SpvB also mono-ADP ribosylates actin as do the iota and C2 toxins, cells treated with a cell-permeating C/SpvB fusion toxin became rounded but recovered and remained viable. Moreover, unmodified actin reappeared in these cells, and ADP-ribosyltransferase activity due to C/SpvB was not detectable in the cytosol after 24 h, a result most likely due to degradation of C/SpvB. Repeated application of C/SpvB prevented recovery of cells and reappearance of unmodified actin. In conclusion, a complete but transient ADP ribosylation of actin was not sufficient to trigger apoptosis, implying that long-term stability of actin-ADP-ribosylating toxins, such as iota and C2, in the cytosol is crucial for inducing delayed, caspase-dependent cell death. C1 [Hilger, Hanna; Pust, Sascha; Kaiser, Eva; Barth, Holger] Univ Ulm, Med Ctr, Inst Pharmacol & Toxicol, D-89081 Ulm, Germany. [von Figura, Guido] Univ Freiburg, Inst Expt & Clin Pharmacol & Toxicol, D-79104 Freiburg, Germany. [Stiles, Bradley G.] USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. [Stiles, Bradley G.] Wilson Coll, Chambersburg, PA USA. [Popoff, Michel R.] Inst Pasteur, CNR Anaerobes & Botulism, Anaerob Bacteria & Toxins Unit, Paris, France. RP Barth, H (reprint author), Univ Ulm, Med Ctr, Inst Pharmacol & Toxicol, Albert Einstein Allee 11, D-89081 Ulm, Germany. EM holger.barth@uni-ulm.de RI Barth, Holger/E-7920-2013; Pust, Sascha/M-3201-2013 OI Pust, Sascha/0000-0002-0178-2206 FU Deutsche Forschungsgemeinschaft (DFG) [BA 2087/1-3] FX This work was supported by the Deutsche Forschungsgemeinschaft (DFG) Priority Program SPP 1150 grant to H. B. (no. BA 2087/1-3). We thank Ulrike Binder (Ulm) for excellent technical assistance. We thank Alexander Burkle (Konstanz) for kindly providing the anti-PARP-1 antibody C-II-10. NR 33 TC 17 Z9 17 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 EI 1098-5522 J9 INFECT IMMUN JI Infect. Immun. PD DEC PY 2009 VL 77 IS 12 BP 5593 EP 5601 DI 10.1128/IAI.00710-09 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 519LC UT WOS:000271767100042 PM 19805536 ER PT J AU Fonseca, DM Smith, JL Kim, HC Mogi, M AF Fonseca, Dina M. Smith, Julie L. Kim, Heung-Chul Mogi, Motoyoshi TI Population genetics of the mosquito Culex pipiens pallens reveals sex-linked asymmetric introgression by Culex quinquefasciatus SO INFECTION GENETICS AND EVOLUTION LA English DT Article DE Hybridization; Genetic introgression; Speciation; Invasive species; Disease vectors; Asia; Sex-linked ID MULTIPLE INTRODUCTIONS; ACETYLCHOLINESTERASE GENE; NATURAL HYBRIDIZATION; LARVICIDAL ACTIVITY; HYBRID ZONE; ACE GENE; CULICIDAE; DIPTERA; COMPLEX; EVOLUTION AB The Culex pipiens complex in Asia includes a temperate subspecies, Culex pipiens pallens, of uncertain taxonomic status. The shape of the male genitalia suggests it is a hybrid between Cx. pipiens and Cx. quinquefasciatus. We studied populations of Cx p. pallens in Japan, Korea, and China and compared them to local populations of Cx quinquefasciatus and Cx. p. pipiens. We examined variation in a nuclear intron in the acetylcholinesterase-2 gene [ACE] and eight microsatellite loci. We found a distinct microsatellite signature for Cx. p. pallens indicating restricted gene flow between Eastern and Western populations of Cx. pipiens, supporting the existence of two subspecies. Furthermore, a multilocus genotype analysis revealed current hybridization between Cx A pallens and Cx. quinquefasciatus in southern Japan, Republic of Korea, and China but not in Hokkaido, in northern Japan. Surprisingly, however, we found that the sex-linked ACE locus in chromosome I has introgressed asymmetrically through the males such that all male Cx. p. pallens have a copy of the Cx quinquefasciatus ACE locus. This result highlights some of the potential consequences of hybridization between local and introduced species to disease transmission worldwide. (C) 2009 Elsevier B.V. All rights reserved. C1 [Fonseca, Dina M.] Rutgers State Univ, Ctr Vector Biol, New Brunswick, NJ 08901 USA. [Smith, Julie L.] Smithsonian Inst, Genet Program, Washington, DC 20560 USA. [Kim, Heung-Chul] USA, Med Detachment 5, Med Command 18, APO, AP 96205 USA. [Mogi, Motoyoshi] Saga Med Sch, Dept Microbiol, Saga 8498501, Japan. RP Fonseca, DM (reprint author), Rutgers State Univ, Ctr Vector Biol, 180 Jones Av, New Brunswick, NJ 08901 USA. EM dinafons@rci.rutgers.edu RI Meyer, Julie/D-1021-2010; Fonseca, Dina/B-9951-2011 OI Meyer, Julie/0000-0003-3382-3321; Fonseca, Dina/0000-0003-4726-7100 FU NIH [R01GMO63258] FX Financial support: NIH R01GMO63258. NR 46 TC 17 Z9 18 U1 0 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1567-1348 J9 INFECT GENET EVOL JI Infect. Genet. Evol. PD DEC PY 2009 VL 9 IS 6 BP 1197 EP 1203 DI 10.1016/j.meegid.2009.06.023 PG 7 WC Infectious Diseases SC Infectious Diseases GA 537HU UT WOS:000273104700020 PM 19584006 ER PT J AU Lee, BB Bergan, J Gloviczki, P Laredo, J Loose, DA Mattassi, R Parsi, K Villavicencio, JL Zamboni, P AF Lee, B. B. Bergan, J. Gloviczki, P. Laredo, J. Loose, D. A. Mattassi, R. Parsi, K. Villavicencio, J. L. Zamboni, P. TI Diagnosis and treatment of venous malformations Consensus Document of the International Union of Phlebology (IUP)-2009 SO INTERNATIONAL ANGIOLOGY LA English DT Article ID KLIPPEL-TRENAUNAY-SYNDROME; CONGENITAL VASCULAR MALFORMATIONS; BUDD-CHIARI-SYNDROME; INFERIOR VENA-CAVA; ARTERIOVENOUS SHUNTING MALFORMATION; SODIUM TETRADECYL SULFATE; SOFT-TISSUE HEMANGIOMAS; BLOOD-POOL SCINTIGRAPHY; JUGULAR-VEIN ANEURYSM; PERCUTANEOUS SCLEROTHERAPY C1 [Lee, B. B.; Laredo, J.] Georgetown Univ, Sch Med, Ctr Vein Lymphat & Vasc Malformat, Div Vasc Surg,Dept Surg, Washington, DC USA. [Bergan, J.] Univ Calif San Diego, Dept Surg, UCSD Sch Med, San Diego, CA 92103 USA. [Gloviczki, P.] Mayo Clin, Div Vasc & Endovasc Surg, Coll Med, Dept Surg, Rochester, MN USA. [Gloviczki, P.] Mayo Clin, Gonda Vasc Ctr, Rochester, MN USA. [Loose, D. A.] Facharztklin Hamburg, Dept Vasc Surg, European Ctr Diag & Treatment Vasc Malformat, Hamburg, Germany. [Mattassi, R.] G Salvini Hosp, Dept Vasc Surg, Stefan Belov Ctr Vasc Malformat, Milan, Italy. [Parsi, K.] Australian Coll Phlebol, Sydney, NSW, Australia. [Parsi, K.] Univ New S Wales, Sydney, NSW 2052, Australia. [Villavicencio, J. L.] Uniformed Serv Univ Hlth Sci, Dept Surg, Sch Med, Bethesda, MD 20814 USA. [Villavicencio, J. L.] Walter Reed Army Med Ctr, Venous & Lymphat Teaching Clin, Bethesda, MD USA. [Zamboni, P.] Univ Ferrara, Vasc Dis Ctr, I-44100 Ferrara, Italy. RP Lee, BB (reprint author), Georgetown Univ, Sch Med, Ctr Vein Lymphat & Vasc Malformat, Div Vasc Surg,Dept Surg, Washington, DC USA. EM bblee38@comcast.net RI Parsi, Kurosh/D-2060-2012 NR 238 TC 55 Z9 57 U1 0 U2 3 PU EDIZIONI MINERVA MEDICA PI TURIN PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY SN 0392-9590 J9 INT ANGIOL JI Int. Angiol. PD DEC PY 2009 VL 28 IS 6 BP 434 EP 451 PG 18 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 582QK UT WOS:000276612600003 PM 20087280 ER PT J AU Silverstone, SA AF Silverstone, Scott A. TI World Out of Balance: International Relations and the Challenge of American Primacy SO INTERNATIONAL HISTORY REVIEW LA English DT Book Review C1 [Silverstone, Scott A.] US Mil Acad, West Point, NY 10996 USA. RP Silverstone, SA (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0707-5332 EI 1949-6540 J9 INT HIST REV JI Int. Hist. Rev. PD DEC PY 2009 VL 31 IS 4 BP 927 EP 930 PG 4 WC History SC History GA 529PG UT WOS:000272529100057 ER PT J AU Silverstone, SA AF Silverstone, Scott A. TI Striking First: Preemption and Prevention in International Conflict SO INTERNATIONAL HISTORY REVIEW LA English DT Book Review C1 [Silverstone, Scott A.] US Mil Acad, West Point, NY 10996 USA. RP Silverstone, SA (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0707-5332 EI 1949-6540 J9 INT HIST REV JI Int. Hist. Rev. PD DEC PY 2009 VL 31 IS 4 BP 927 EP 930 PG 4 WC History SC History GA 529PG UT WOS:000272529100058 ER PT J AU Lyall, J Wilson, I AF Lyall, Jason Wilson, Isaiah, III TI Rage Against the Machines: Explaining Outcomes in Counterinsurgency Wars SO INTERNATIONAL ORGANIZATION LA English DT Article ID CIVIL-WAR; ASYMMETRIC CONFLICT; INSURGENCY AB During the nineteenth century, states routinely defeated insurgent foes. Over the twentieth Century, however, this pattern reversed itself , with states increasingly less likely to defeat insurgents or avoid meeting at least some of their demands. What accounts for this pattern of outcomes in counterinsurgency (COIN) wars? We argue that increasing mechanization within state militaries after World War I is primarily responsible for this shift. Unlike their nineteenth-century predecessors, modern militaries possess Force structures that inhibit information collection among local populations. This not only complicates the process of sifting insurgents from noncombatants but increases the difficulty of selectively applying rewards and punishment among the fence-sitting population. Modern militaries may therefore inadvertently fuel, rather than deter, insurgencies. We test this argument with a new data set of 286 insurgencies (1800-2005) and a paired comparison of two U.S. Army divisions in Iraq (2003-2004). We find that higher levels of mechanization, along with external support for insurgents and the counterinsurgent's status as an occupier, are associated with an increased probability of state defeat. By contrast, we find only partial support for conventional power- and regime-based explanations, and no support for the view that rough terrain favors insurgent success. C1 [Lyall, Jason] Princeton Univ, Princeton, NJ 08544 USA. [Wilson, Isaiah, III] US Mil Acad, Dept Social Sci, West Point, PA USA. RP Lyall, J (reprint author), Princeton Univ, Princeton, NJ 08544 USA. EM jlyall@princeton.edu; isaiah.wilson@usma.edu NR 84 TC 97 Z9 98 U1 2 U2 28 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0020-8183 EI 1531-5088 J9 INT ORGAN JI Int. Organ. PD WIN PY 2009 VL 63 IS 1 BP 67 EP 106 DI 10.1017/S0020918309090031 PG 40 WC International Relations; Political Science SC International Relations; Government & Law GA 397WV UT WOS:000262693900003 ER PT J AU Galloway, GE Boesch, DF Twilley, RR AF Galloway, Gerald E. Boesch, Donald F. Twilley, Robert R. TI Restoring and Protecting Coastal Louisiana SO ISSUES IN SCIENCE AND TECHNOLOGY LA English DT Article C1 [Boesch, Donald F.] Univ Maryland, Ctr Environm Sci, College Pk, MD 20742 USA. [Galloway, Gerald E.] USA, Corps Engineers, Washington, DC USA. [Twilley, Robert R.] Louisiana State Univ, Baton Rouge, LA 70803 USA. EM gegallo@umd.edu NR 8 TC 3 Z9 3 U1 0 U2 3 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0748-5492 J9 ISSUES SCI TECHNOL JI Issues Sci. Technol. PD WIN PY 2009 VL 25 IS 2 BP 29 EP 38 PG 10 WC Engineering, Multidisciplinary; Engineering, Industrial; Multidisciplinary Sciences; Social Issues SC Engineering; Science & Technology - Other Topics; Social Issues GA 390ZZ UT WOS:000262203500021 ER PT J AU Lauer, AM Molis, M Leek, MR AF Lauer, Amanda M. Molis, Michelle Leek, Marjorie R. TI Discrimination of Time-Reversed Harmonic Complexes by Normal-Hearing and Hearing-Impaired Listeners SO JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY LA English DT Article DE harmonic complex; hearing impairment; Schroeder phase; stimulus uncertainty; frequency sweep ID TEMPORAL FINE-STRUCTURE; BASILAR-MEMBRANE RESPONSES; COCHLEAR-IMPLANT LISTENERS; MASKING PERIOD PATTERNS; AUDITORY FILTER SHAPES; FALSE DISCOVERY RATE; GAP DETECTION; INFORMATIONAL MASKING; SPEECH-PERCEPTION; PHASE RESPONSE AB Normal-hearing (NH) listeners and hearing-impaired (HI) listeners detected and discriminated time-reversed harmonic complexes constructed of equal-amplitude harmonic components with fundamental frequencies (F0s) ranging from 50 to 800 Hz. Component starting phases were selected according to the positive and negative Schroeder-phase algorithms to produce within-period frequency sweeps with relatively flat temporal envelopes. Detection thresholds were not affected by component starting phases for either group of listeners. At presentation levels of 80 dB SPL, NH listeners could discriminate the two waveforms nearly perfectly when the F0s were less than 300-400 Hz but fell to chance performance for higher F0s. HI listeners performed significantly poorer, with reduced discrimination at several of the F0s. In contrast, at a lower presentation level meant to nearly equate sensation levels for the two groups, NH listeners' discrimination was poorer than HI listeners at most F0s. Roving presentation levels had little effect on performance by NH listeners but reduced performance by HI listeners. The differential impact of roving level suggests a weaker perception of timbre differences and a greater susceptibility to the detrimental effects of experimental uncertainty in HI listeners. C1 [Lauer, Amanda M.; Molis, Michelle; Leek, Marjorie R.] Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, Washington, DC 20307 USA. [Lauer, Amanda M.] Univ Maryland, Dept Psychol, College Pk, MD 20742 USA. [Lauer, Amanda M.; Leek, Marjorie R.] Univ Maryland, Ctr Comparat Evolutionary Biol Hearing, College Pk, MD 20742 USA. RP Lauer, AM (reprint author), Johns Hopkins Univ, 521 Traylor Res Bldg,720 Rutland Ave, Baltimore, MD 21205 USA. EM alauer2@jhmi.edu; Michelle.Molis@va.gov; Marjorie.Leek@va.gov OI Lauer, Amanda/0000-0003-4184-7374 FU Department of Veterans Affairs [R01 DC00626, DC04664]; Army or the Department of Defense FX This work was supported by R01 DC00626 (MRL) and DC04664 (AML). The authors are grateful to Dr. Garnett McMillan for statistical assistance, to Lina Kubli for assistance with data collection, and to three anonymous reviewers, as well as the Associate Editor, for their thoughtful comments on an earlier version of this paper. This work was supported in part by the Department of Veterans Affairs. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. NR 61 TC 3 Z9 3 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1525-3961 J9 JARO-J ASSOC RES OTO JI JARO PD DEC PY 2009 VL 10 IS 4 BP 609 EP 619 DI 10.1007/s10162-009-0182-y PG 11 WC Neurosciences; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 516LO UT WOS:000271543900011 PM 19705203 ER PT J AU Holmes, RO Hartzell, JD Tofferi, JK Roebuck, JD Kelly, WF AF Holmes, Robert O., Jr. Hartzell, Joshua D. Tofferi, Jeanne K. Roebuck, Jonathan D. Kelly, William F. TI Dual High Titer Antineutrophil Cytoplasmic Autoantibodies in Association With Systemic Q Fever SO JCR-JOURNAL OF CLINICAL RHEUMATOLOGY LA English DT Article ID PROTEINASE-3; EPIDEMIOLOGY; EXPRESSION C1 [Holmes, Robert O., Jr.; Hartzell, Joshua D.; Tofferi, Jeanne K.; Roebuck, Jonathan D.; Kelly, William F.] Walter Reed Army Med Ctr, Rheumatol Serv, Washington, DC 20307 USA. RP Holmes, RO (reprint author), Natl Naval Med Ctr, Dept Rheumatol, Med Serv, Bldg 9,8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM robert.holmes2@med.navy.mil NR 17 TC 4 Z9 4 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-1608 J9 JCR-J CLIN RHEUMATOL JI JCR-J. Clin. Rheumatol. PD DEC PY 2009 VL 15 IS 8 BP 411 EP 413 DI 10.1097/RHU.0b013e3181c3f8a8 PG 3 WC Rheumatology SC Rheumatology GA 531IU UT WOS:000272659100012 PM 19956002 ER PT J AU Dagnon, KL Thellen, C Ratto, JA D'Souza, NA AF Dagnon, Koffi L. Thellen, Christopher Ratto, Jo Ann D'Souza, Nandika A. TI Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) Coatings on Kraft Paper SO JOURNAL OF BIOBASED MATERIALS AND BIOENERGY LA English DT Article DE Poly(3-hydroxybutyrate-co-4-hydroxybutyrate); Kraft Paper; Coatings; Packaging ID FUNCTIONAL-PROPERTIES; MECHANICAL-PROPERTIES; CELLULOSE; POLYHYDROXYALKANOATES; CRYSTALLIZATION; BARRIER; BLENDS; PHB/V; FTIR AB Structural, thermomechanical and mechanical characteristics of Kraft paper coated with poly(3-hydroxybutyrate-co-4-hydroxybutyrate) P(3HB-co-4HB) have been been investigated using solvent and melt coating methods. Environmental scanning electron microscopy (ESEM) was used to study the surface and cross-sectional uniformity of the coatings. Wide angle X ray diffraction (WAXD) and Fourier transform infrared spectroscopy (FTIR) were utilized to evaluate the change in crystallinity of the biopolymer. Dynamic mechanical analysis (DMA) and impact testing were used to investigate the mechanical properties of the coatings. The coatings were effective in increasing the moduli of the Kraft paper as indicated by DMA. Impact results conducted at room temperature showed that the melt coated samples had a higher total energy absorption capability indicating superior adhesion to the solvent coated samples. C1 [Dagnon, Koffi L.; D'Souza, Nandika A.] Univ N Texas, Dept Mat Sci & Engn, Denton, TX 76203 USA. [Thellen, Christopher; Ratto, Jo Ann] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. RP D'Souza, NA (reprint author), Univ N Texas, Dept Mat Sci & Engn, POB 305310, Denton, TX 76203 USA. EM ndsouza@unt.edu OI DSouza, Nandika/0000-0002-8553-0347 FU SERDP (Strategic Environmental Research and Development Program) FX Financial Support from SERDP (Strategic Environmental Research and Development Program) is gratefully acknowledged. NR 23 TC 2 Z9 3 U1 2 U2 18 PU AMER SCIENTIFIC PUBLISHERS PI STEVENSON RANCH PA 25650 NORTH LEWIS WAY, STEVENSON RANCH, CA 91381-1439 USA SN 1556-6560 J9 J BIOBASED MATER BIO JI J. Biobased Mater. Bioenergy PD DEC PY 2009 VL 3 IS 4 BP 418 EP 428 DI 10.1166/jbmb.2009.1048 PG 11 WC Chemistry, Applied; Energy & Fuels; Materials Science, Biomaterials SC Chemistry; Energy & Fuels; Materials Science GA 550EC UT WOS:000274110100013 ER PT J AU Lu, XCM Si, YZ Williams, AJ Hartings, JA Gryder, D Tortella, FC AF Lu, Xi-Chun M. Si, Yuanzheng Williams, Anthony J. Hartings, Jed A. Gryder, Divina Tortella, Frank C. TI NNZ-2566, a glypromate analog, attenuates brain ischemia-induced non-convulsive seizures in rats SO JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM LA English DT Article DE brain ischemia; EEG; NNZ-2566; rats; seizures ID GLYCINE-PROLINE-GLUTAMATE; N-TERMINAL TRIPEPTIDE; INTENSIVE-CARE UNIT; GROWTH-FACTOR-I; STATUS EPILEPTICUS; EPILEPSY; INJURY; INFLAMMATION; PATHOPHYSIOLOGY; ACTIVATION AB Ischemic and traumatic brain injuries often induce non-convulsive seizures (NCSs), which likely contribute to the worsening of neurological outcomes. Here, we evaluated the effect of glycyl-L-methylprolyl-L-glutamic acid (NNZ-2566) to lessen the severity of NCSs caused by permanent middle cerebral artery occlusion (pMCAo). Continuous electroencephalographic recordings were performed in rats during pMCAo. Glycyl-L-methylprolyl-L-glutamic acid (3, 10, or 100 mg/kg bolus followed by an infusion of a fixed dose of 3 mg/kg per hour for 12 h) was delivered at 20 mins after pMCAo (before the first NCS event) or delayed until immediately after the first NCS event occurred. Control rats received pMCAo and saline treatment. The results revealed that 91% of the saline-treated animals had NCSs (23 episodes per rat and 1238 secs per rat) with an onset latency of 35 mins after injury. When NNZ-2566 was administered before the NCS events, it dose-dependently reduced the NCS incidence to 36%-80%, decreased NCS frequency to 5-16 episodes per rat, and shortened the total duration of NCS to 251-706 secs per rat. The two high doses significantly reduced the infarct volume by 28%-30%. Delayed treatment also attenuated NCS duration but had no effect on the infarct volume. Results indicate that NNZ-2566 possesses a unique therapeutic potential as a safe prophylactic agent that synergistically provides neuroprotection and reduces injury-induced seizures. Journal of Cerebral Blood Flow & Metabolism (2009) 29, 1924-1932; doi:10.1038/jcbfm.2009.109; published online 29 July 2009 C1 [Lu, Xi-Chun M.; Si, Yuanzheng; Williams, Anthony J.; Hartings, Jed A.; Gryder, Divina; Tortella, Frank C.] Walter Reed Army Inst Res, Div Psychiat & Neurosci, Dept Appl Neurobiol, Silver Spring, MD 20910 USA. RP Lu, XCM (reprint author), Walter Reed Army Inst Res, Div Psychiat & Neurosci, Dept Appl Neurobiol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM may.lu@us.army.mil FU CRADA (Cooperative Research and Development Agreement) with Neuren Pharmaceuticals Ltd. [W81XWH-050074] FX We would like to thank Ms Angela Fleming, Ms Xiaofang Yang, Mr Paul Guevarra, and Ms Ying Cao for their invaluable assistance in the technical aspects of this study, and Ms Christine Gallo for her review and comments on the paper. These studies were supported in part by a CRADA (Cooperative Research and Development Agreement) with Neuren Pharmaceuticals Ltd. (W81XWH-050074). NR 28 TC 15 Z9 15 U1 0 U2 2 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0271-678X J9 J CEREBR BLOOD F MET JI J. Cereb. Blood Flow Metab. PD DEC PY 2009 VL 29 IS 12 BP 1924 EP 1932 DI 10.1038/jcbfm.2009.109 PG 9 WC Endocrinology & Metabolism; Hematology; Neurosciences SC Endocrinology & Metabolism; Hematology; Neurosciences & Neurology GA 524ZJ UT WOS:000272182600007 PM 19638995 ER PT J AU Rinderspacher, BC Andzelm, J Rawlett, A Dougherty, J Beratan, DN Yang, WT AF Rinderspacher, B. Christopher Andzelm, Jan Rawlett, Adam Dougherty, Joseph Beratan, David N. Yang, Weitao TI Discrete Optimization of Electronic Hyperpolarizabilities in a Chemical Subspace SO JOURNAL OF CHEMICAL THEORY AND COMPUTATION LA English DT Article ID NONLINEAR-OPTICAL PROPERTIES; COMBINATORIAL OPTIMIZATION; DESIGNING MOLECULES; POTENTIALS; ALGORITHMS AB We introduce a general optimization algorithm based on an interpolation of property values on a hypercube. Each vertex of the hypercube represents a molecule, while the interior of the interpolation represents a virtual superposition ("alchemical" mutation) of molecules. The resultant algorithm is similar to branch-and-bound/tree-search methods. We apply the algorithm to the optimization of the first electronic hyperpolarizability for several tolane libraries. The search includes structural and conformational information. Geometries were optimized using the AM1 Hamiltonian, and first hyperpolarizabilities were computed using the INDO/S method. Even for small libraries, a significant improvement of the hyperpolarizability, up to a factor of ca. 4, was achieved. The algorithm was validated for efficiency and reproduced known experimental results. The algorithm converges to a local optimum at a computational cost on the order of the logarithm of the library size, making large libraries accessible. For larger libraries, the improvement was accomplished by performing electronic structure calculations on less than 0.01% of the compounds in the larger libraries. Alternation of electron donating and accepting groups in the tolane scaffold was found to produce candidates with large hyperpolarizabilities consistently. C1 [Rinderspacher, B. Christopher; Andzelm, Jan; Rawlett, Adam; Dougherty, Joseph] USA, Res Lab, Aberdeen, MD 21005 USA. [Rinderspacher, B. Christopher; Beratan, David N.; Yang, Weitao] Duke Univ, Dept Chem, Durham, NC 27708 USA. RP Rinderspacher, BC (reprint author), USA, Res Lab, Aberdeen, MD 21005 USA. EM berend.rinderspacher@arl.army.mil RI Beratan, David/C-5098-2011; Yang, Weitao/C-1109-2008 FU DARPA [W911NF-04-1-0243]; Army Research Laboratory FX We Would like to thank S. Keinan B. Desinghu, G. Lindsay, A. Chafin, and M. Davis for helpful discussions. We are thankful to DARPA Predicting Real Optimized Materials through ARO (W911NF-04-1-0243) and the Army Research Laboratory for funding. NR 30 TC 13 Z9 13 U1 1 U2 16 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1549-9618 J9 J CHEM THEORY COMPUT JI J. Chem. Theory Comput. PD DEC PY 2009 VL 5 IS 12 BP 3321 EP 3329 DI 10.1021/ct900325p PG 9 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 527VB UT WOS:000272395200015 PM 26602512 ER PT J AU Perrig, A Trappe, W Gligor, V Poovendran, R Lee, H AF Perrig, Adrian Trappe, Wade Gligor, Virgil Poovendran, Radha Lee, Heejo TI Secure Wireless Networking SO JOURNAL OF COMMUNICATIONS AND NETWORKS LA English DT Editorial Material C1 [Perrig, Adrian] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA. [Perrig, Adrian] Carnegie Mellons Cybersecur Lab CyLab, Pittsburgh, PA USA. [Trappe, Wade] Rutgers State Univ, Dept Elect & Comp Engn, Piscataway, NJ 08855 USA. [Gligor, Virgil] Univ Maryland, College Pk, MD 20742 USA. [Gligor, Virgil] IBM Corp, Armonk, NY 10504 USA. [Poovendran, Radha] Univ Washington, Dept Elect Engn, Network Secur Lab, Seattle, WA 98195 USA. [Poovendran, Radha] Univ Washington, Army Res Off Workshop CPS Secur, Seattle, WA 98195 USA. [Lee, Heejo] Korea Univ, Div Comp & Commun Engn, Seoul, South Korea. RP Perrig, A (reprint author), Carnegie Mellon Univ, Pittsburgh, PA 15213 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU KOREAN INST COMMUNICATIONS SCIENCES (K I C S) PI SEOUL PA HYUNDAI KIRIM OFFICETEL 1504-6 SEOCHODONG 1330-18, SEOCHOKU, SEOUL 137-070, SOUTH KOREA SN 1229-2370 J9 J COMMUN NETW-S KOR JI J. Commun. Netw. PD DEC PY 2009 VL 11 IS 6 SI SI BP 533 EP 537 PG 5 WC Computer Science, Information Systems; Telecommunications SC Computer Science; Telecommunications GA 541SP UT WOS:000273441200001 ER PT J AU Karkkainen, RL Tzeng, JT AF Karkkainen, Ryan L. Tzeng, Jerome T. TI Micromechanical Strength Modeling and Investigation of Stitch Density Effects on 3D Orthogonal Composites SO JOURNAL OF COMPOSITE MATERIALS LA English DT Article DE textile reinforcement; micromechanics; finite element method ID WEAVE TEXTILE COMPOSITES; FAILURE MECHANISMS; SYSTEMS AB A 3D orthogonal woven S2-glass composite is investigated using finite element micromechanics to characterize the stiffness and the strength. The methods are applied to a targeted parametric investigation of the effects of stitch density on strength properties and potential benefits of through-thickness reinforcement, such as resistance to transverse shear and delamination, with some consequent loss of in-plane properties. Direct modeling of the exact microstructure from scanning electron microscope visualization provides a precise knowledge of the mechanics and the failure modes of the microstructure under various loading conditions. Modeling results are verified by comparison to experimental data. In-plane stiffness and strength are predicted with 90% or better accuracy. Transverse shear stiffness was less well predicted, but strength was still predicted within 86% accuracy. C1 [Karkkainen, Ryan L.; Tzeng, Jerome T.] USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Karkkainen, RL (reprint author), USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM ryan.karkkainen@arl.army.mil NR 22 TC 12 Z9 12 U1 0 U2 5 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0021-9983 J9 J COMPOS MATER JI J. Compos Mater. PD DEC PY 2009 VL 43 IS 25 BP 3125 EP 3142 DI 10.1177/0021998309345329 PG 18 WC Materials Science, Composites SC Materials Science GA 524XI UT WOS:000272177300007 ER PT J AU Rose, KA Adamack, AT Murphy, CA Sable, SE Kolesar, SE Craig, JK Breitburg, DL Thomas, P Brouwer, MH Cerco, CF Diamond, S AF Rose, Kenneth A. Adamack, Aaron T. Murphy, Cheryl A. Sable, Shaye E. Kolesar, Sarah E. Craig, J. Kevin Breitburg, Denise L. Thomas, Peter Brouwer, Marius H. Cerco, Carl F. Diamond, Sandra TI Does hypoxia have population-level effects on coastal fish? Musings from the virtual world SO JOURNAL OF EXPERIMENTAL MARINE BIOLOGY AND ECOLOGY LA English DT Article DE Avoidance; Community; Dissolved oxygen; Fish; Hypoxia; Model; Population ID GULF-OF-MEXICO; CROAKER MICROPOGONIAS-UNDULATUS; ESTUARY-DEPENDENT FISHES; ATLANTIC CROAKER; CHESAPEAKE BAY; PATUXENT RIVER; INFREQUENT DISTURBANCES; ENDOCRINE DISRUPTION; MARINE ECOSYSTEMS; HABITAT QUALITY AB Hypoxia is often associated with increasing nutrient loadings and has clear mortality effects on sessile organisms, but its population effects on mobile organisms in coastal environments are uncertain. The evidence for hypoxia having population level effects is laboratory experiments, many examples of localized effects in nature, a few population-level examples, fish kills, and intuition. Despite the perception by many people, none of these provide conclusive evidence of widespread population responses to hypoxia. We synthesize the results from seven ecological simulation models that examined how low dissolved oxygen (DO) affected fish at the individual. population, and community levels. These models represent a variety of species, simulate the dynamics at a range of temporal scales and spatial scales, and impose a variety of subsets of possible DO effects. Several patterns emerged from the accumulated results. First, predicted responses were large in simpler models, and small to large in more complex models. Second, while the main effects of increased hypoxia were generally small to moderate, there were instances of relatively large indirect effects and interaction effects. Indirect effects involved growth and mortality responses due to altered spatial distribution (rather than due directly to DO) and food web interactions. Interaction effects were larger responses to hypoxia when other factors were at certain levels (e.g., responses at low versus high fish densities). Interactions also occurred when the predicted responses were larger than would be expected by the sum of the separate effects. Third, accurate information on exposure and degree of avoidance of low DO were critical unknowns. Our interpretations should be viewed as suggestive rather than definitive. The patterns described were based on a collection of modeling results that were not designed to be compared to each other. A quick look at other models seems to confirm our patterns, or at minimum, does not contradict our patterns. Quantifying the effects of hypoxia on fish populations, whether large or small, is critical for effective management of coastal ecosystems and for cost-effective and efficient design of remediation actions. The potential for interaction and indirect effects complicates field study and management. Improving our predictions of the effects of hypoxia on fish populations and communities has moved from a computational issue to a biological issue. We seem to be making progress on monitoring and modeling movement behavior, but progress is slower in food web theory and empirical research and in quantifying interspecific interactions and habitat quality in terms of process rates that relate to population dynamics. (C) 2009 Elsevier B.V. All rights reserved. C1 [Rose, Kenneth A.; Sable, Shaye E.] Louisiana State Univ, Dept Oceanog & Coastal Sci, Baton Rouge, LA 70803 USA. [Adamack, Aaron T.] Univ Michigan, Cooperat Inst Limnol & Ecosyst Res, Ann Arbor, MI 48105 USA. [Murphy, Cheryl A.] Michigan State Univ, Dept Fisheries & Wildlife, E Lansing, MI 48824 USA. [Kolesar, Sarah E.] St Marys Coll Maryland, Dept Biol, St Marys City, MD 20686 USA. [Craig, J. Kevin] Florida State Univ, Coastal & Marine Lab, St Teresa, FL 32358 USA. [Breitburg, Denise L.] Smithsonian Environm Res Ctr, Edgewater, MD 21037 USA. [Thomas, Peter] Univ Texas, Inst Marine Sci, Port Aransas, TX 78373 USA. [Brouwer, Marius H.] Univ So Mississippi, Gulf Coast Res Lab, Ocean Springs, MS 39564 USA. [Cerco, Carl F.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Diamond, Sandra] Texas Tech Univ, Dept Biol Sci, Lubbock, TX 79409 USA. RP Rose, KA (reprint author), Louisiana State Univ, Dept Oceanog & Coastal Sci, Energy Coast & Environm Bldg, Baton Rouge, LA 70803 USA. EM karose@lsu.edu OI Adamack, Aaron/0000-0002-9746-5351 FU US Environmental Protection Agency's Science to Achieve Results (STAR) Estuarine and Great Lakes (EaGLe) program; Consortium for Estuarine Ecoindicator Research for the Gulf of Mexico (CEER-GOM; US EPA Agreement [R82945801]; US Army Engineer District, Baltimore; US EPA Chesapeake Bay Program Office: NOAA's Coastal Ocean Program: Louisiana Sea; National Oceanic and Atmospheric Administration, Center for Sponsored Coastal Ocean Research (CSCOR) [NA06NOS4780131]; US EPA FX The first author (KAR) was involved with all of the models. Collaborators on each of the models were included as co-authors on this paper because of their critical role in the development of their respective models and the shaping of ideas presented in this paper. KAR assumes responsibility for the content of the entire paper. Funding for development of the various models was provided by: the US Environmental Protection Agency's Science to Achieve Results (STAR) Estuarine and Great Lakes (EaGLe) program through funding to the Consortium for Estuarine Ecoindicator Research for the Gulf of Mexico (CEER-GOM; US EPA Agreement R82945801); US Army Engineer District, Baltimore; US EPA Chesapeake Bay Program Office: NOAA's Coastal Ocean Program: Louisiana Sea Grant as part of a joint North Carolina, Delaware, and Louisiana project, and Maryland Sea Grant. Preparation of this paper was supported by the National Oceanic and Atmospheric Administration, Center for Sponsored Coastal Ocean Research (CSCOR), NGOMEX06 grant number NA06NOS4780131 awarded to the University of Texas. This is publication number 106 of the NOAA's CSCOR NGOMEX06 program, and NOAA-GLERL contribution 1507. Although the research described in this article was funded wholly or in part by the US EPA, it has not been subjected to the Agency's required peer and policy review and, therefore, does not necessarily reflect the views of the Agency and no official endorsement should be inferred. [SS] NR 88 TC 21 Z9 22 U1 2 U2 31 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0981 EI 1879-1697 J9 J EXP MAR BIOL ECOL JI J. Exp. Mar. Biol. Ecol. PD DEC 1 PY 2009 VL 381 SU 1 BP S188 EP S203 DI 10.1016/j.jembe.2009.07.022 PG 16 WC Ecology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA 525HV UT WOS:000272206800020 ER PT J AU Kapoor, A Li, L Victoria, J Oderinde, B Mason, C Pandey, P Zaidi, SZ Delwart, E AF Kapoor, A. Li, L. Victoria, J. Oderinde, B. Mason, C. Pandey, P. Zaidi, S. Z. Delwart, E. TI Multiple novel astrovirus species in human stool SO JOURNAL OF GENERAL VIROLOGY LA English DT Article ID DIARRHEA; VIRUSES; IDENTIFICATION; CHILDREN; SEQUENCES; CHINA; GASTROENTERITIS; HEPATITIS; TYPE-3; ASSAY AB Diarrhoea remains a significant cause of morbidity and mortality in developing countries where numerous cases remain without identified aetiology. Astroviruses are a recently identified cause of animal gastroenteritis which currently includes two species suspected of causing human diarrhoea. Using pan-astrovirus RT-PCR, we analysed human stool samples from different continents for astrovirus-related RNA sequences. We identified variants of the two known human astrovirus species plus, based on genetic distance criteria, three novel astrovirus species all distantly related to mink and ovine astroviruses, which we provisionally named HMOAstV species A-C. The complete genome of species A displayed all the conserved characteristics of mammalian astroviruses. Each of the now three groups of astroviruses found in human stool (HAstV, AstV-MLB and HMOAstV) were more closely related to animal astroviruses than to each other, indicating that human astroviruses may periodically emerge from zoonotic transmissions. Based on the pathogenic impact of their closest phylogenetic relatives in animals, further investigations of the role of HMOAstV, so far detected in Nigeria, Nepal and Pakistan, in human gastroenteritis are warranted. C1 [Kapoor, A.; Li, L.; Victoria, J.; Delwart, E.] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA. [Kapoor, A.; Li, L.; Victoria, J.; Delwart, E.] Blood Syst Res Inst, San Francisco, CA USA. [Oderinde, B.] Univ Maiduguri, Teaching Hosp, WHO Natl Polio Lab, Maiduguri, Borno State, Nigeria. [Mason, C.] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand. [Pandey, P.] CIWEC Clin Travel Med Ctr, Kathmandu, Nepal. [Zaidi, S. Z.] NIH, Dept Virol, Islamabad, Pakistan. RP Delwart, E (reprint author), Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA. EM delwarte@medicine.ucsf.edu RI Li, Linlin/E-3335-2010; OI Delwart, Eric/0000-0002-6296-4484 FU NHLBI [R0HL083254] FX We thank Drs Marycelin Mandu Baba and David Nadeba Bukbuk from the WHO National Polio Laboratory, University of Maiduguri Teaching Hospital, Borno State, Nigeria, for assistance with samples from non-polio AFP children; and Drs John McGee, Jason Reilly and Nlats Rynge from the Renaissance COMPLIting Institute (RENCI) for assistance with cloud computing analysis of the pyrosequencing data. We also thank Drs Farbod Babrzadeh, Chunlin Wang and Baback Gharizadeh at Stanford University for assistance Nvith pyrosequencing and bioinforniatics, Dr Micheal P. Busch and the Blood Systems Research Institute for Sustained support and NHLBI grant R0HL083254 to E.D. NR 34 TC 96 Z9 104 U1 0 U2 6 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 0022-1317 J9 J GEN VIROL JI J. Gen. Virol. PD DEC PY 2009 VL 90 BP 2965 EP 2972 DI 10.1099/vir.0.014449-0 PG 8 WC Biotechnology & Applied Microbiology; Virology SC Biotechnology & Applied Microbiology; Virology GA 525ZX UT WOS:000272258200017 PM 19692544 ER PT J AU Sills, GL Vroman, ND Wahl, RE Schwanz, NT AF Sills, G. L. Vroman, N. D. Wahl, R. E. Schwanz, N. T. TI Closure to "Overview of New Orleans Levee Failures: Lessons Learned and Their Impact on National Levee Design and Assessment" by G. L. Sills, N. D. Vroman, R. E. Wahl, and N. T. Schwanz SO JOURNAL OF GEOTECHNICAL AND GEOENVIRONMENTAL ENGINEERING LA English DT Editorial Material ID HURRICANE; KATRINA C1 [Sills, G. L.; Vroman, N. D.] USA, Corps Engineers, GEEB, GSD,GSL,ERDC, Vicksburg, MS 39180 USA. [Wahl, R. E.] USACE, Airfields & Pavements Branch, Engn Syst & Mat Div, GSL,ERDC, Vicksburg, MS 39180 USA. [Schwanz, N. T.] USACE, St Paul, MN 55101 USA. RP Vroman, ND (reprint author), USA, Corps Engineers, GEEB, GSD,GSL,ERDC, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM george.l.sills@erdc.usace.army.mil; noah.d.vroman@erdc.usace.army.mil; ronald.e.wahl@erdc.usace.army.mil; neil.t.schwanz@usace.army.mil NR 7 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1090-0241 J9 J GEOTECH GEOENVIRON JI J. Geotech. Geoenviron. Eng. PD DEC PY 2009 VL 135 IS 12 BP 1994 EP 1995 DI 10.1061/(ASCE)GT.1943-5606.0000197 PG 2 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 524ZB UT WOS:000272181800023 ER PT J AU Duncan, JM Brandon, TL Wright, SG Vroman, ND AF Duncan, J. Michael Brandon, Thomas L. Wright, Stephen G. Vroman, Noah D. TI Closure to "Stability of I-Walls in New Orleans during Hurricane Katrina" by J. Michael Duncan, Thomas L. Brandon, Stephen G. Wright, and Noah D. Vroman SO JOURNAL OF GEOTECHNICAL AND GEOENVIRONMENTAL ENGINEERING LA English DT Editorial Material C1 [Duncan, J. Michael; Brandon, Thomas L.] Virginia Tech, Dept Civil & Environm Engn, Blacksburg, VA 24061 USA. [Wright, Stephen G.] Univ Texas Austin, Dept Civil Engn, Austin, TX 78712 USA. [Vroman, Noah D.] USACE, Erdc, Vicksburg, MS 39180 USA. RP Duncan, JM (reprint author), Virginia Tech, Dept Civil & Environm Engn, 200 Patton Hall, Blacksburg, VA 24061 USA. EM jmd@vt.edu; tb@vt.edu; swright@mail.utexas.edu; noah.d.vroman@erdc.usace.army.mil NR 4 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1090-0241 J9 J GEOTECH GEOENVIRON JI J. Geotech. Geoenviron. Eng. PD DEC PY 2009 VL 135 IS 12 BP 2002 EP 2004 DI 10.1061/(ASCE)GT.1943-5606.0000223 PG 3 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 524ZB UT WOS:000272181800026 ER PT J AU Kaba, SA Brando, C Guo, Q Mittelholzer, C Raman, S Tropel, D Aebi, U Burkhard, P Lanar, DE AF Kaba, Stephen A. Brando, Clara Guo, Qin Mittelholzer, Christian Raman, Senthilkumar Tropel, David Aebi, Ueli Burkhard, Peter Lanar, David E. TI A Nonadjuvanted Polypeptide Nanoparticle Vaccine Confers Long-Lasting Protection against Rodent Malaria SO JOURNAL OF IMMUNOLOGY LA English DT Article ID FALCIPARUM CIRCUMSPOROZOITE PROTEIN; MEROZOITE SURFACE PROTEIN-1; PRIME-BOOST IMMUNIZATION; T-CELL EPITOPES; DENDRITIC CELLS; B-CELL; PEPTIDE NANOPARTICLES; PLASMODIUM-BERGHEI; IMMUNE-RESPONSES; CORE PARTICLE AB We have designed and produced a prototypic malaria vaccine based on a highly versatile self-assembling polypeptide nanoparticle (SAPN) platform that can repetitively display antigenic epitopes. We used this platform to display a tandem repeat of the B cell immunodominant repeat epitope (DPPPPNPN)(2)D of the malaria parasite Plasmodium berghei circumsporozoite protein. Administered in saline, without the need for a heterologous adjuvant, the SAPN construct P4c-Mal conferred a long-lived, protective immune response to mice with a broad range of genetically distinct immune backgrounds including the H-2(b), H-2(d), and H-2(k) alleles. Immunized mice produced a CD4(+) T cell-dependent, high-titer, long-lasting, high-avidity Ab response against the B cell epitope. Mice were protected against an initial challenge of parasites up to 6 mo after the last immunization or for up to 15 mo against a second challenge after an initial challenge of parasites had successfully been cleared. Furthermore, we demonstrate that the SAPN platform not only functions to deliver an ordered repetitive array of B cell peptide epitopes but operates as a classical immunological carrier to provide cognate help to the P4c-Mal-specific B cells. The Journal of Immunology, 2009,183: 7268-7277. C1 [Kaba, Stephen A.; Brando, Clara; Guo, Qin; Lanar, David E.] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. [Mittelholzer, Christian; Raman, Senthilkumar; Tropel, David; Aebi, Ueli] ME Muller Inst, Basel, Switzerland. [Burkhard, Peter] Univ Connecticut, Dept Mol & Cell Biol, Inst Mat Sci, Storrs, CT 06269 USA. RP Lanar, DE (reprint author), Walter Reed Army Inst Res, Div Malaria Vaccine Dev, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM david.lanar@us.army.mil RI Kaba, Stephen/B-3555-2011; Lanar, David/B-3560-2011 OI Kaba, Stephen/0000-0003-1509-2975; FU Kommission fur Technologic und Innovation (Switzerland) [8433.1]; Swiss Nanoscience Institute FX C.M., D.T.. and S.R. were supported by the Grants 8433.1 and Peptide NP from the Kommission fur Technologic und Innovation (Switzerland) and the Swiss Nanoscience Institute. NR 68 TC 66 Z9 68 U1 0 U2 9 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD DEC 1 PY 2009 VL 183 IS 11 BP 7268 EP 7277 DI 10.4049/jimmunol.0901957 PG 10 WC Immunology SC Immunology GA 528WX UT WOS:000272478800047 PM 19915055 ER PT J AU Okulicz, JF Marconi, VC Landrum, ML Wegner, S Weintrob, A Ganesan, A Hale, B Crum-Cianflone, N Delmar, J Barthel, V Quinnan, G Agan, BK Dolan, MJ AF Okulicz, Jason F. Marconi, Vincent C. Landrum, Michael L. Wegner, Scott Weintrob, Amy Ganesan, Anuradha Hale, Braden Crum-Cianflone, Nancy Delmar, Judith Barthel, Vincent Quinnan, Gerald Agan, Brian K. Dolan, Matthew J. CA IDCRP HIV Working Grp TI Clinical Outcomes of Elite Controllers, Viremic Controllers, and Long-Term Nonprogressors in the US Department of Defense HIV Natural History Study SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID IMMUNODEFICIENCY-VIRUS-INFECTION; ACTIVE ANTIRETROVIRAL THERAPY; RNA LEVELS; DISEASE PROGRESSION; VIRAL LOAD; CELL COUNT; COHORT; SEROCONVERTERS; INDIVIDUALS; MECHANISMS AB Durable control of human immunodeficiency virus (HIV) replication and lack of disease progression in the absence of antiretroviral therapy were studied in a military cohort of 4586 subjects. We examined groups of elite controllers (ie, subjects with plasma HIV RNA levels of <50 copies/mL; prevalence, 0.55% [95% confidence interval{CI}, 0.35%-0.80%]), viremic controllers ( ie, subjects with plasma HIV RNA levels of 50-2000 copies/mL; prevalence, 3.34% [ 95% CI, 2.83%-3.91%]), and subjects with a lack of disease progression ( ie, long-term nonprogressors [LTNPs]) through 7 years of follow-up (LTNP7s; prevalence, 3.32% [ 95% CI, 2.70%-4.01%]) or 10 years of follow-up (LTNP10s; prevalence, 2.04% [ 95% CI, 1.52%-2.68%]). For elite and viremic controllers, spontaneous virologic control was established early and was typically observed when the initial viral load measurement was obtained within 1 year of estimated seroconversion. Elite controllers had favorable time to development of AIDS (P = .048), a CD4 cell count of 350 cells/mu L (P = .009), and more-stable CD4 cell trends, compared with viremic controllers. LTNPs defined by 10-year versus 7-year criteria had a longer survival time (P = .001), even after adjustment for differing periods of invulnerability (P = .042). Definitions of controllers and LTNPs describe distinct populations whose differing clinical outcomes improve with the stringency of criteria, underscoring the need for comparability between study populations. C1 [Okulicz, Jason F.; Marconi, Vincent C.; Landrum, Michael L.; Wegner, Scott; Weintrob, Amy; Ganesan, Anuradha; Hale, Braden; Crum-Cianflone, Nancy; Barthel, Vincent; Quinnan, Gerald; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Infect Dis Clin, Bethesda, MD USA. [Okulicz, Jason F.; Marconi, Vincent C.; Landrum, Michael L.; Delmar, Judith; Dolan, Matthew J.] Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Dolan, Matthew J.] Wilford Hall USAF Med Ctr, Henry M Jackson Fdn, Lackland AFB, TX 78236 USA. [Weintrob, Amy] Walter Reed Army Med Ctr, Infect Dis Clin, Washington, DC 20307 USA. [Hale, Braden; Crum-Cianflone, Nancy] USN, San Diego Med Ctr, Infect Dis Clin, San Diego, CA 92152 USA. [Barthel, Vincent] USN, Med Ctr Portsmouth, Infect Dis Clin, Portsmouth, VA USA. RP Okulicz, JF (reprint author), Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Jason.okulicz@amedd.army.mil RI Marconi, Vincent/N-3210-2014; OI Marconi, Vincent/0000-0001-8409-4689; Agan, Brian/0000-0002-5114-1669 NR 32 TC 117 Z9 121 U1 4 U2 7 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD DEC 1 PY 2009 VL 200 IS 11 BP 1714 EP 1723 DI 10.1086/646609 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 518AP UT WOS:000271662100014 PM 19852669 ER PT J AU Grussing, MN Uzarski, DR Marrano, LR AF Grussing, Michael N. Uzarski, Donald R. Marrano, Lance R. TI Building Infrastructure Functional Capacity Measurement Framework SO JOURNAL OF INFRASTRUCTURE SYSTEMS LA English DT Article DE Performance characteristics; System analysis; Serviceability; Buildings; Measurement AB Building infrastructure "performance" is a term which describes the in-service functioning of a building for a specified use. The concept refers to how effectively, safely, and efficiently a building supports its mission at any time during its life cycle. A building's performance state, which changes during time in service, is reflected by two different indicators: the physical condition state and the functionality state. The physical condition state relates to a facility's general "physical fitness," independent of its mission, as it deteriorates due to routine aging, excessive or abusive use, or poor maintenance. The functionality state relates to the facility's suitability to function as intended and required for the mission. The functionality state is distinct and independent from the physical condition state. Condition-based metrics are currently in use but a companion index of functionality was not developed at the same time. However, in order to fully describe a building's fitness for changing missions over its entire life cycle, a quantitative and objective functionality index (FI) is needed. This paper describes the methodology of this FI measurement. C1 [Grussing, Michael N.; Marrano, Lance R.] Erdc, CERL, Champaign, IL 61826 USA. [Uzarski, Donald R.] Uzarski Engn, Champaign, IL 61821 USA. RP Grussing, MN (reprint author), Erdc, CERL, POB 9005, Champaign, IL 61826 USA. EM michael.n.grussing@erdc.usace.army.mil; d.uzarski@insightbb.com; lance.r.marrano@erdc.usace.army.mil FU Engineer Research and Development Center-Construction Engineering Research Laboratory (ERDC-CERL); Naval Facilities Engineering Command (NAVFAC) FX Building functionality assessment has been cosponsored by Engineer Research and Development Center-Construction Engineering Research Laboratory (ERDC-CERL) and the Naval Facilities Engineering Command (NAVFAC). The views of the writers expressed in this paper do not purport to represent the views or policies of the departments of the Army, Navy, or Defense. NR 8 TC 3 Z9 3 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1076-0342 J9 J INFRASTRUCT SYST JI J. Infrastruct. Syst. PD DEC PY 2009 VL 15 IS 4 BP 371 EP 377 DI 10.1061/(ASCE)1076-0342(2009)15:4(371) PG 7 WC Engineering, Civil SC Engineering GA 520FX UT WOS:000271827600014 ER PT J AU Grujicic, M Glomski, PS He, T Arakere, G Bell, WC Cheeseman, BA AF Grujicic, M. Glomski, P. S. He, T. Arakere, G. Bell, W. C. Cheeseman, B. A. TI Material Modeling and Ballistic-Resistance Analysis of Armor-Grade Composites Reinforced with High-Performance Fibers SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE armor-grade composites; failure analysis; high-performance fibers; material modeling; polymer-matrix composites ID LAMINATED KEVLAR; IMPACT; PENETRATION; PROJECTILES; MECHANISMS; FAILURE; EPOXY AB A new ballistic material model for 0A degrees/90A degrees cross-plied oriented ultra-high molecular weight (UHMW) polyethylene fiber-based armor-grade composite laminates has been constructed using open-literature data for the fiber and polymeric-matrix material properties and the general experimental/field-test observations regarding the deformation and failure modes in these types of materials. The present model is an extension of our recently developed unit cell-based ballistic material model for the same class of composites (M. Grujicic, G. Arakere, T. He,W.C. Bell, B. A. Cheeseman, C.-F. Yen, and B. Scott, A Ballistic Material Model for Cross-Plied Unidirectional Ultra-High Molecular-Weight Polyethylene Fiber-reinforced Armor-Grade Composites, Mater. Sci. Eng, A 2008, 498(1-2), p 231-241) which was found to be physically sound, but computationally not very efficient. The present model is constructed in such a way that it can be readily integrated into commercial finite element programs like ANSYS/Autodyn (ANSYS/Autodyn version 11.0, User Documentation, Century Dynamics Inc., a subsidiary of ANSYS Inc., 2007), as a User Material Subroutine. To validate the model, a series of transient nonlinear dynamics computational analyses of the transverse impact of armor-grade composite laminates with two types of bullets/projectiles is carried out and the computational results compared with their experimental counterparts. Relatively good agreement is found between the experiment and the computational analysis relative to: (a) the success of the armor panels of different areal densities in defeating the bullets at different initial bullet velocities; (b) postmortem spatial distribution of the damage modes and the extents within the panels; (c) the temporal evolution of the armor-panel back-face bulge; and (d) The existence of three distinct armor-penetration stages (i.e., an initial filament shearing/cutting dominated stage, an intermediate stage characterized by pronounced filament/matrix debonding/decohesion, and a final stage associated with the extensive filaments extension and armor-panel back-face bulging). C1 [Grujicic, M.; Glomski, P. S.; He, T.; Arakere, G.; Bell, W. C.] Clemson Univ, Dept Mech Engn, ICAR, Clemson, SC 29634 USA. [Cheeseman, B. A.] USA, Res Lab, Survivabil Mat Branch, Aberdeen, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, ICAR, Clemson, SC 29634 USA. EM mica.grujicic@ces.clemson.edu FU U. S. Army/Clemson University Cooperative [W911NF-04-2-0024, W911NF-06-2-0042] FX The material presented in this article is based on the work supported by the U. S. Army/Clemson University Cooperative Agreements W911NF-04-2-0024 and W911NF-06-2-0042. NR 37 TC 35 Z9 36 U1 2 U2 23 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD DEC PY 2009 VL 18 IS 9 BP 1169 EP 1182 DI 10.1007/s11665-009-9370-5 PG 14 WC Materials Science, Multidisciplinary SC Materials Science GA 519FJ UT WOS:000271750100003 ER PT J AU Benzinger, TLS Brody, D Cardin, S Curley, KC Mintun, MA Mun, SK Wong, KH Wrathall, JR AF Benzinger, Tammie L. S. Brody, David Cardin, Sylvain Curley, Kenneth C. Mintun, Mark A. Mun, Seong K. Wong, Kenneth H. Wrathall, Jean R. CA Workshop Sci Organizing Team Prese TI Blast-Related Brain Injury: Imaging for Clinical and Research Applications: Report of the 2008 St. Louis Workshop SO JOURNAL OF NEUROTRAUMA LA English DT Article DE animal models of blast-related injury; blast physics; blast-related traumatic brain injury; brain imaging; post-traumatic stress disorder ID MAGNETIC-RESONANCE-SPECTROSCOPY; OPERATION-IRAQI-FREEDOM; WHITE-MATTER; HEAD-INJURY; TEMPORAL WINDOW; COMBAT VETERANS; VULNERABILITY; ASSOCIATION; TRAUMA; HUMANS AB Blast-related traumatic brain injury (bTBI) and post-traumatic stress disorder (PTSD) have been of particular relevance to the military and civilian health care sectors since the onset of the Global War on Terror, and TBI has been called the "signature injury'' of this war. Currently there are many questions about the fundamental nature, diagnosis, and long-term consequences of bTBI and its relationship to PTSD. This workshop was organized to consider these questions and focus on how brain imaging techniques may be used to enhance current diagnosis, research, and treatment of bTBI. The general conclusion was that although the study of blast physics in non-biological systems is mature, few data are presently available on key topics such as blast exposure in combat scenarios, the pathological characteristics of human bTBI, and imaging signatures of bTBI. Addressing these gaps is critical to the success of bTBI research. Foremost among our recommendations is that human autopsy and pathoanatomical data from bTBI patients need to be obtained and disseminated to the military and civilian research communities, and advanced neuroimaging used in studies of acute, subacute, and chronic cases, to determine whether there is a distinct pathoanatomical signature that correlates with long-term functional impairment, including PTSD. These data are also critical for the development of animal models to illuminate fundamental mechanisms of bTBI and provide leads for new treatment approaches. Brain imaging will need to play an increasingly important role as gaps in the scientific knowledge of bTBI and PTSD are addressed through increased coordination, cooperation, and data sharing among the academic and military biomedical research communities. C1 [Wong, Kenneth H.; Wrathall, Jean R.] Georgetown Univ, Med Ctr, Washington, DC 20057 USA. [Benzinger, Tammie L. S.; Brody, David; Mintun, Mark A.] Washington Univ, Mallinckrodt Inst Radiol, St Louis, MO USA. [Cardin, Sylvain; Curley, Kenneth C.] USA, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. [Mun, Seong K.] Virginia Polytech Inst & State Univ, Blacksburg, VA 24061 USA. [Curley, Kenneth C.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Walter Reed Army Inst Res, Silver Spring, MD USA. Naval Med Res Ctr, Silver Spring, MD USA. Univ Texas Galveston, Med Branch, Galveston, TX 77550 USA. Univ Maryland, College Pk, MD 20742 USA. James S McDonnell Fdn, St Louis, MO USA. Med Coll Wisconsin, Milwaukee, WI 53226 USA. Weill Cornell Med Coll, New York, NY USA. Univ Calif Los Angeles, Los Angeles, CA USA. Univ Pittsburgh, Pittsburgh, PA USA. St Louis Vet Adm, Med Ctr, St Louis, MO USA. Natl Inst Neurol Disorders & Stroke, Bethesda, MD USA. Univ Illinois, Coll Med, Chicago, IL USA. Def & Vet Brain Injury Ctr, Washington, DC USA. Univ Calif San Francisco, San Francisco, CA USA. Virginia Commonwealth Univ, Richmond, VA USA. Vet Adm Puget Sound Hlth Care Syst, Seattle, WA USA. Univ Washington, Med Ctr, Seattle, WA 98195 USA. Virginia Hosp Ctr, Arlington, VA USA. Dyn FX Consulting Ltd, Toronto, ON, Canada. Univ Penn, Philadelphia, PA 19104 USA. Banyan Biomarkers Inc, Alachua, FL USA. Wayne State Univ, Detroit, MI USA. [Cardin, Sylvain; Curley, Kenneth C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Wrathall, JR (reprint author), Georgetown Univ, Med Ctr, 3970 Reservoir Rd,NW, Washington, DC 20057 USA. EM Wrathali_@georgetown.edu OI Kochanek, Patrick/0000-0002-2627-913X; Bayly, Philip/0000-0003-4303-0704; Pancrazio, Joseph/0000-0001-8276-3690; Mukherjee, Pratik/0000-0001-7473-7409 NR 77 TC 42 Z9 43 U1 0 U2 4 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD DEC PY 2009 VL 26 IS 12 BP 2127 EP 2144 DI 10.1089/neu.2009.0885 PG 18 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 536AI UT WOS:000273013200001 PM 19508154 ER PT J AU Kilbourne, M Kuehn, R Tosun, C Caridi, J Keledjian, K Bochicchio, G Scalea, T Gerzanich, V Simard, JM AF Kilbourne, Michael Kuehn, Reed Tosun, Cigdem Caridi, John Keledjian, Kaspar Bochicchio, Grant Scalea, Thomas Gerzanich, Volodymyr Simard, J. Marc TI Novel Model of Frontal Impact Closed Head Injury in the Rat SO JOURNAL OF NEUROTRAUMA LA English DT Article DE activated caspase-3; beta-amyloid precursor protein; diffuse axonal injury; frontal impact; impact acceleration; traumatic brain injury ID TRAUMATIC BRAIN-INJURY; AMYLOID PRECURSOR PROTEIN; DIFFUSE AXONAL INJURY; FLUID PERCUSSION INJURY; ACCELERATION; BIOMECHANICS; DEFICITS; PEPTIDE; DAMAGE; MILD AB Frontal impact, closed head trauma is a frequent cause of traumatic brain injury (TBI) in motor vehicle and sports accidents. Diffuse axonal injury (DAI) is common in humans and experimental animals, and results from shearing forces that develop within the anisotropic brain. Because the specific anisotropic properties of the brain are axis-dependent, the anatomical site where force is applied as well as the resultant acceleration, be it linear, rotational, or some combination, are important determinants of the resulting pattern of brain injury. Available rodent models of closed head injury do not reproduce the frontal impact commonly encountered in humans. Here we describe a new rat model of closed head injury that is a modification of the impact-acceleration model of Marmarou. In our model (the Maryland model), the impact force is applied to the anterior part of the cranium and produces TBI by causing anterior-posterior plus sagittal rotational acceleration of the brain inside the intact cranium. Skull fractures, prolonged apnea, and mortality were absent. The animals exhibited petechial hemorrhages, DAI marked by a bead-like pattern of beta-amyloid precursor protein (beta-APP) in damaged axons, and widespread upregulation of beta-APP in neurons, with regions affected including the orbitofrontal cortex (coup), corpus callosum, caudate, putamen, thalamus, cerebellum, and brainstem. Activated caspase-3 was prominent in hippocampal neurons and Purkinje cells at the grey-white matter junction of the cerebellum. Neurobehavioral dysfunction, manifesting as reduced spontaneous exploration, lasted more than 1 week. We conclude that the Maryland model produces diffuse injuries that may be relevant to human brain injury. C1 [Tosun, Cigdem; Caridi, John; Gerzanich, Volodymyr; Simard, J. Marc] Univ Maryland, Sch Med, Dept Neurosurg, Baltimore, MD 21201 USA. [Kilbourne, Michael; Kuehn, Reed] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Keledjian, Kaspar; Bochicchio, Grant; Scalea, Thomas] Univ Maryland, Sch Med, Dept Surg, Baltimore, MD 21201 USA. [Simard, J. Marc] Univ Maryland, Sch Med, Dept Physiol, Baltimore, MD 21201 USA. [Simard, J. Marc] Univ Maryland, Sch Med, Dept Pathol, Baltimore, MD 21201 USA. [Bochicchio, Grant; Scalea, Thomas; Simard, J. Marc] R Adams Cowley Shock Trauma Ctr, Baltimore, MD USA. RP Simard, JM (reprint author), Univ Maryland, Sch Med, Dept Neurosurg, 22 S Greene St,Suite S12D, Baltimore, MD 21201 USA. EM msimard@smail.umaryland.edu FU Department of Veterans Affairs (Baltimore, MD); National Heart, Lung, and Blood Institute [HL082517]; National Institute of Neurological Disorders and Stroke [NS061808, NS060801, NS061934]; Christopher and Dana Reeve Foundation FX This work was supported by grants to J.M.S. from the Department of Veterans Affairs (Baltimore, MD), the National Heart, Lung, and Blood Institute (no. HL082517), the National Institute of Neurological Disorders and Stroke (no. NS061808 and NS060801), and the Christopher and Dana Reeve Foundation, and to V. G. from the National Institute of Neurological Disorders and Stroke (no. NS061934). NR 40 TC 27 Z9 31 U1 4 U2 9 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD DEC PY 2009 VL 26 IS 12 BP 2233 EP 2243 DI 10.1089/neu.2009.0968 PG 11 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 536AI UT WOS:000273013200011 PM 19929375 ER PT J AU Simard, JM Kilbourne, M Tsymbalyuk, O Tosun, C Caridi, J Ivanova, S Keledjian, K Bochicchio, G Gerzanich, V AF Simard, J. Marc Kilbourne, Michael Tsymbalyuk, Orest Tosun, Cigdem Caridi, John Ivanova, Svetlana Keledjian, Kaspar Bochicchio, Grant Gerzanich, Volodymyr TI Key Role of Sulfonylurea Receptor 1 in Progressive Secondary Hemorrhage after Brain Contusion SO JOURNAL OF NEUROTRAUMA LA English DT Article DE contusion; glibenclamide; hemorrhage; sulfonylurea receptor 1; traumatic brain injury ID SPINAL-CORD-INJURY; NONSELECTIVE CATION CHANNEL; LATERAL FLUID PERCUSSION; ADULT-RAT BRAIN; ISCHEMIC-STROKE; VASCULAR DISRUPTION; REACTIVE ASTROCYTES; HEAD TRAUMA; GLIBENCLAMIDE; CELLS AB An important but poorly understood feature of traumatic brain injury (TBI) is the clinically serious problem of spatiotemporal progression ("blossoming'') of a hemorrhagic contusion, a phenomenon we term progressive secondary hemorrhage (PSH). Molecular mechanisms of PSH are unknown and efforts to reduce it by promoting coagulation have met with equivocal results. We hypothesized that PSH might be due to upregulation and activation of sulfonylurea receptor 1 (SUR1)-regulated NCCa-ATP channels in capillary endothelial cells, predisposing to oncotic death of endothelial cells and catastrophic failure of capillary integrity. Anesthetized adult male rats underwent left parietal craniectomy for induction of a focal cortical contusion. The regulatory subunit of the channel, SUR1, was prominently upregulated in capillaries of penumbral tissues surrounding the contusion. In untreated rats, PSH was characterized by progressive enlargement of the contusion deep into the site of cortical impact, including corpus callosum, hippocampus, and thalamus, by progressive accumulation of extravasated blood, with a doubling of the volume during the first 12 h after injury, and by capillary fragmentation in penumbral tissues. Block of SUR1 using low-dose (non-hypoglycemogenic) glibenclamide largely eliminated PSH and capillary fragmentation, and was associated with a significant reduction in the size of the necrotic lesion and in preservation of neurobehavioral function. Antisense oligodeoxynucleotide against SUR1, administered after injury, reduced both SUR1 expression and PSH, consistent with a requirement for transcriptional upregulation of SUR1. Our findings provide novel insights into molecular mechanisms responsible for PSH associated with hemorrhagic contusions, and point to SUR1 as a potential therapeutic target in TBI. C1 [Simard, J. Marc; Tsymbalyuk, Orest; Tosun, Cigdem; Caridi, John; Ivanova, Svetlana; Keledjian, Kaspar; Gerzanich, Volodymyr] Univ Maryland, Sch Med, Dept Neurosurg, Baltimore, MD 21201 USA. [Simard, J. Marc] Univ Maryland, Sch Med, Dept Pathol, Baltimore, MD 21201 USA. [Simard, J. Marc] Univ Maryland, Sch Med, Dept Physiol, Baltimore, MD 21201 USA. [Bochicchio, Grant] Univ Maryland, Sch Med, Dept Surg, Baltimore, MD 21201 USA. [Kilbourne, Michael] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Bochicchio, Grant] R Adams Cowley Shock Trauma Ctr, Baltimore, MD USA. RP Simard, JM (reprint author), Univ Maryland, Sch Med, Dept Neurosurg, Baltimore, MD 21201 USA. EM msimard@smail.umaryland.edu FU Department of Veterans Affairs (Baltimore, MD); National Heart, Lung and Blood Institute [HL082517]; National Institute of Neurological Disorders and Stroke [NS061808, NS060801, NS061934]; Christopher and Dana Reeve Foundation FX This work was supported by grants to J.M.S. from the Department of Veterans Affairs (Baltimore, MD), the National Heart, Lung and Blood Institute (HL082517), the National Institute of Neurological Disorders and Stroke (NS061808 and NS060801), and the Christopher and Dana Reeve Foundation, and to V. G. from the National Institute of Neurological Disorders and Stroke (NS061934). NR 54 TC 43 Z9 46 U1 0 U2 2 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD DEC PY 2009 VL 26 IS 12 BP 2257 EP 2267 DI 10.1089/neu.2009.1021 PG 11 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 536AI UT WOS:000273013200013 PM 19604096 ER PT J AU Jackson, WM Aragon, AB Bulken-Hoover, JD Nesti, LJ Tuan, RS AF Jackson, Wesley M. Aragon, Amber B. Bulken-Hoover, Jamie D. Nesti, Leon J. Tuan, Rocky S. TI Putative Heterotopic Ossification Progenitor Cells Derived from Traumatized Muscle SO JOURNAL OF ORTHOPAEDIC RESEARCH LA English DT Article DE mesenchymal progenitor cells; mesenchymal stem cells; osteoprogenitor cells; heterotopic ossification; osteogenesis ID MESENCHYMAL STEM-CELLS; HUMAN BONE-MARROW; OSTEOGENIC DIFFERENTIATION; SKELETAL-MUSCLE; TISSUE AB Heterotopic ossification (HO) is a frequent complication following combat-related trauma, but the pathogenesis of traumatic HO is poorly understood. Building on our recent identification of mesenchymal progenitor cells (MPCs) in traumatically injured muscle, the goal of this study was to evaluate the osteogenic potential of the MPCs in order to assess the role of these cells in HO formation. Compared to bone marrow-derived mesenchymal stem cells (MSCs), a well-characterized population of osteoprogenitor cells, the MPCs exhibited several significant differences during osteogenic differentiation and in the expression of genes related to osteogenesis. Upon osteogenic induction, MPCs showed increased alkaline phosphatase activity, production of a mineralized matrix, and up-regulated expression of the osteoblast-associated genes CBFA1 and alkaline phosphatase. However, MPCs did not appear to reach terminal differentiation as the expression of osteocalcin was not substantially up-regulated. With the exception of a few genes, the osteogenic gene expression profile of traumatized muscle-derived MPCs was comparable to that of the MSCs after osteogenic induction. These findings indicate that traumatized muscle-derived MPCs have the potential to function as osteoprogenitor cells when exposed to the appropriate biochemical environment and are the putative osteoprogenitor cells that initiate ectopic bone formation in HO. (C) 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27:1645-1.651, 2009 C1 [Jackson, Wesley M.; Aragon, Amber B.; Bulken-Hoover, Jamie D.; Nesti, Leon J.; Tuan, Rocky S.] NIAMSD, Cartilage Biol & Orthopaed Branch, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA. [Aragon, Amber B.; Bulken-Hoover, Jamie D.; Nesti, Leon J.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. [Nesti, Leon J.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. RP Tuan, RS (reprint author), NIAMSD, Cartilage Biol & Orthopaed Branch, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA. EM tuanr@mail.nih.gov FU Military Amputee Research Program at WRAMC [PO5-A011]; NIH NIAMS Intramural Research Program [Z01 AR41131] FX This study was supported by a grant from the Military Amputee Research Program at WRAMC (PO5-A011) and by the NIH NIAMS Intramural Research Program (Z01 AR41131). Dr. Nesti and Dr. Tuan were co-senior authors of this article. NR 22 TC 41 Z9 41 U1 0 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0736-0266 J9 J ORTHOP RES JI J. Orthop. Res. PD DEC PY 2009 VL 27 IS 12 BP 1645 EP 1651 DI 10.1002/jor.20924 PG 7 WC Orthopedics SC Orthopedics GA 523UV UT WOS:000272101000016 PM 19517576 ER PT J AU Aracava, Y Pereira, EFR Akkerman, M Adler, M Albuquerque, EX AF Aracava, Yasco Pereira, Edna F. R. Akkerman, Miriam Adler, Michael Albuquerque, Edson X. TI Effectiveness of Donepezil, Rivastigmine, and (+/-)Huperzine A in Counteracting the Acute Toxicity of Organophosphorus Nerve Agents: Comparison with Galantamine SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS LA English DT Article ID SOMAN-INDUCED SEIZURES; NICOTINIC ACETYLCHOLINE-RECEPTORS; CHOLINESTERASE-INHIBITORS; GUINEA-PIG; RAT-BRAIN; PRETREATMENT; EFFICACY; HUPERZINE; PYRIDOSTIGMINE; GALANTHAMINE AB Galantamine, a centrally acting cholinesterase (ChE) inhibitor and a nicotinic allosteric potentiating ligand used to treat Alzheimer's disease, is an effective and safe antidote against poisoning with nerve agents, including soman. Here, the effectiveness of galantamine was compared with that of the centrally active ChE inhibitors donepezil, rivastigmine, and (+/-)huperzine A as a pre- and/or post-treatment to counteract the acute toxicity of soman. In the first set of experiments, male prepubertal guinea pigs were treated intramuscularly with one of the test drugs and 30 min later challenged with 1.5 x LD(50) soman (42 mu g/kg s.c.). All animals that were pretreated with galantamine (6-8 mg/kg), 3 mg/kg donepezil, 6 mg/kg rivastigmine, or 0.3 mg/kg (+/-)huperzine A survived the soman challenge, provided that they were also post-treated with atropine (10 mg/kg i.m.). However, only galantamine was well tolerated. In subsequent experiments, the effectiveness of specific treatment regimens using 8 mg/kg galantamine, 3 mg/kg donepezil, 6 mg/kg rivastigmine, or 0.3 mg/kg (+/-)huperzine A was compared in guinea pigs challenged with soman. In the absence of atropine, only galantamine worked as an effective and safe pretreatment in animals challenged with 1.0 x LD(50) soman. Galantamine was also the only drug to afford significant protection when given to guinea pigs after 1.0 x LD(50) soman. Finally, all test drugs except galantamine reduced the survival of the animals when administered 1 or 3 h after the challenge with 0.6 or 0.7 x LD(50) soman. Thus, galantamine emerges as a superior antidotal therapy against the toxicity of soman. C1 [Aracava, Yasco; Pereira, Edna F. R.; Akkerman, Miriam; Albuquerque, Edson X.] Univ Maryland, Sch Med, Dept Pharmacol & Expt Therapeut, Baltimore, MD 21201 USA. [Adler, Michael] USA, Med Res Inst Chem Def, Neurobehav Toxicol Branch, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA. RP Albuquerque, EX (reprint author), 655 W Baltimore St, Baltimore, MD 21201 USA. EM ealbuque@umaryland.edu FU Army Research Office [W911NF-06-1-0098]; National Institutes of Health National Institute of Neurological Disorders and Stroke [UO1NS059344] FX This work was supported by the Army Research Office [Contract W911NF-06-1-0098]; and the National Institutes of Health National Institute of Neurological Disorders and Stroke [Grant UO1NS059344] (CounterACT Program). NR 43 TC 10 Z9 10 U1 0 U2 10 PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA SN 0022-3565 J9 J PHARMACOL EXP THER JI J. Pharmacol. Exp. Ther. PD DEC PY 2009 VL 331 IS 3 BP 1014 EP 1024 DI 10.1124/jpet.109.160028 PG 11 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 523RY UT WOS:000272093400027 PM 19741148 ER PT J AU Smallwood, JA Causey, MF Mossop, DH Klucsarits, JR Robertson, B Robertson, S Mason, J Maurer, MJ Melvin, RJ Dawson, RD Bortolotti, GR Parrish, JW Breen, TF Boyd, K AF Smallwood, John A. Causey, Mark F. Mossop, David H. Klucsarits, James R. Robertson, Bob Robertson, Sue Mason, Joey Maurer, Michael. J. Melvin, Richard J. Dawson, Russell D. Bortolotti, Gary R. Parrish, John W., Jr. Breen, Timothy F. Boyd, Kenneth TI WHY ARE AMERICAN KESTREL (FALCO SPARVERIUS) POPULATIONS DECLINING IN NORTH AMERICA? EVIDENCE FROM NEST-BOX PROGRAMS SO JOURNAL OF RAPTOR RESEARCH LA English DT Article DE American Kestrel; Falco sparverius; nest boxes; population decline ID WEST-NILE-VIRUS; FLORIDA AB Declines in American Kestrel (Falco sparverius) populations are widely reported, and Breeding Bird Survey (BBS) data Suggest that the North American population declined significantly from 1984 to 2007. Potential causes include the spread of West. Nile virus (WNV), increases in populations of Cooper's Hawks (Accipiter cooperii), and loss of suitable habitat. We examined trends in the numbers of both migratory and resident kestrel populations that Use nest boxes in eight study areas in Florida, Georgia, Virginia and Maryland, New Jersey, Massachusetts, Pennsylvania, Saskatchewan, and the Yukon Territory, 1984-2007. All eight populations underwent significant declines; the mean annual decline in nest-box occupancy rate was 3.0% and ranged from 0.6% in Pennsylvania to 4.7% in New Jersey. Except for the most recent nest-box program, established in 1995 and declining since 2002, all nest-box populations began to experience declines before WNV arrived in North America in 1999. To test whether changes in kestrel population densities generally are associated with the opposite trend in Cooper's Hawks, we examined the 42 BBS physiographic regions for which trends for both species were available. No significant correlations were detected for the period 1966-2007, or for 1980-2007, more closely concurrent with Our nest-box data. Christmas Bird Count data front 1959 through 1988 also failed to demonstrate a significant correlation. Finally, the habitat within our study areas still appears suitable, and die remaining kestrels appear healthy and have high reproductive success. Thus, the principal cause of die decline probably lies elsewhere, perhaps on the wintering grounds or along migration routes. Further, for both migratory and resident. populations, the decline in nest-box occupancy may reflect regional declines, which would reduce the number of individuals available for replacing breeding birds that have died or dispersed. C1 [Smallwood, John A.] Montclair State Univ, Dept Biol & Mol Biol, Montclair, NJ 07043 USA. [Mossop, David H.] Yukon Coll, Whitehorse, YT Y1A 4H5, Canada. [Klucsarits, James R.] Alvernia Coll, Reading, PA 19607 USA. [Melvin, Richard J.] Amer Kestrel Fdn, High Springs, FL 32655 USA. [Dawson, Russell D.] Univ No British Columbia, Prince George, BC V2N 4Z9, Canada. [Bortolotti, Gary R.] Univ Saskatchewan, Dept Biol, Saskatoon, SK S7N 5E2, Canada. [Parrish, John W., Jr.; Breen, Timothy F.] Georgia So Univ, Dept Biol, Statesboro, GA 30460 USA. [Boyd, Kenneth] US Army Corps Engn, Clarks Hill, SC 29821 USA. RP Smallwood, JA (reprint author), Montclair State Univ, Dept Biol & Mol Biol, Montclair, NJ 07043 USA. EM smallwoodj@montclair.edu FU Natural Sciences and Engineering Research Council of Canada; Georgia DNR; Arcadia Wildlife Preserve, Inc; Nongaine Program; Florida Game and Fresh water Fish Commission; Margaret and Herman Sokol Faculty/Student Research; Separately Budgeted Research Awards; Montclair State University; Faculty Scholarship Program; MSU FX We thank the multitude of field assistants who helped to collect data. especially K.L. Wiebe (Saskatchewan), J. Rusbult (Pennyslvania), and the many undergraduate and graduate students from Montclair State University (New jersey). We gratefully acknowledge GPU Energy and Sussex Rural Electric Cooperative for allowing its to erect nest. boxes oil their utility poles (New Jersey), and the Wallkill River National Wildlife Refuge and local landowners for providing its access to field sites. Funding for the Besnard Lake project was provided by the Natural Sciences and Engineering Research Council of Canada through grants to RDD and GRB. The nest-box program in Georgia was supported by Georgia DNR and Arcadia Wildlife Preserve, Inc. The Florida program received support from a grant to JAS and M.W. Collopy from the Nongaine Program, Florida Game and Fresh water Fish Commission. The New Jersey program was supported by a Margaret and Herman Sokol Faculty/Student Research Grant and by Separately Budgeted Research Awards, Montclair State University and release time for JAS was provided by the Faculty Scholarship Program, MSU. We also thank G. Santolo and K. Steenhof for thoughtful reviews of the manuscript. NR 36 TC 21 Z9 24 U1 4 U2 38 PU RAPTOR RESEARCH FOUNDATION INC PI HASTINGS PA 14377 117TH STREET SOUTH, HASTINGS, MN 55033 USA SN 0892-1016 J9 J RAPTOR RES JI J. Raptor Res. PD DEC PY 2009 VL 43 IS 4 BP 274 EP 282 DI 10.3356/JRR-08-83.1 PG 9 WC Ornithology SC Zoology GA 535TF UT WOS:000272993400003 ER PT J AU Forster, CJ Oglesby, RJ Szkutnik, AJ Roberts, JR AF Forster, Christopher J. Oglesby, Robert J. Szkutnik, Albert J. Roberts, Jefferson R. TI Positive Alizarin Red Clumps in Milwaukee Shoulder Syndrome SO JOURNAL OF RHEUMATOLOGY LA English DT Letter C1 [Forster, Christopher J.] Walter Reed Army Med Ctr, Dept Internal Med, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Rheumatol & Pharm, Washington, DC 20307 USA. RP Forster, CJ (reprint author), Walter Reed Army Med Ctr, Dept Internal Med, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM christopher.forster@us.army.mil NR 4 TC 1 Z9 1 U1 0 U2 0 PU J RHEUMATOL PUBL CO PI TORONTO PA 920 YONGE ST, SUITE 115, TORONTO, ONTARIO M4W 3C7, CANADA SN 0315-162X J9 J RHEUMATOL JI J. Rheumatol. PD DEC PY 2009 VL 36 IS 12 BP 2853 EP 2854 DI 10.3899/jrheum.090163 PG 2 WC Rheumatology SC Rheumatology GA 533WN UT WOS:000272856200047 PM 19966203 ER PT J AU Brechue, WF Mayhew, JL AF Brechue, William F. Mayhew, Jerry L. TI UPPER-BODY WORK CAPACITY AND 1RM PREDICTION ARE UNALTERED BY INCREASING MUSCULAR STRENGTH IN COLLEGE FOOTBALL PLAYERS SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE off-season conditioning; performance evaluation; bench press ID HIGH-INTENSITY; UNTRAINED MEN; BLOOD-FLOW; EXERCISE; ADAPTATIONS; REPETITIONS; WEIGHT; NUMBER AB Brechue, WF and Mayhew, JL. Upper-body work capacity and 1RM prediction are unaltered by increasing muscular strength in college football players. J Strength Cond Res 23(9): 24772486, 2009-The purpose of this study was to assess changes in upper-body muscular strength and work capacity following off-season resistance training and the resultant effect on prediction of muscular strength (1 repetition maximum, or 1RM). National Collegiate Athletic Association (NCAA) Division II football players (n = 58) were divided into low-strength (LS, 1RM <275 lb, n = 23) and high-strength (HS, 1RM >= 275 lb, n = 35) groups based on initial 1RM bench press. Maximal repetitions to failure (RTF) were performed with a relative (60, 70, 80, and 90% of 1RM) and absolute load (185 lb for players with 1RM <275 lb; 225 lb for players with 1RM >= 275 lb) at pre- and post-training. Following training (n = 58), there was a significant increase in 1RM bench press (22.8 +/- 12.0 lb) and body mass (3.7 +/- 10 lb). There was no change in the number of repetitions performed (RTF) during relative load testing following training. However, RTF during absolute load testing was increased. Relative and absolute load work capacity (reps x load) increased with training, but there was no relationship between the change in work capacity and the changes in muscular strength. Predicted 1RMs were better at lower repetitions (3-5 RM, >85% 1RM) than at higher repetitions (>6RM, <= 80% 1RM) at both pre- and post-training. In conclusion, changes in muscular strength associated with the off-season training program used herein appear to have little effect on work capacity or prediction of 1RM using submaximal loads. For repetition predictions to accurately track changes following resistance training, the test load must be relatively high (>85% 1RM) and the repetitions low (<= 5 reps). C1 [Brechue, William F.] US Mil Acad, Ctr Phys Dev Excellence, Dept Phys Educ, West Point, NY 10996 USA. [Mayhew, Jerry L.] Truman State Univ, Human Performance Lab, Kirksville, MO USA. [Mayhew, Jerry L.] AT Still Univ Hlth Sci, Dept Physiol, Kirksville, MO USA. RP Brechue, WF (reprint author), US Mil Acad, Ctr Phys Dev Excellence, Dept Phys Educ, West Point, NY 10996 USA. EM bill.brechue@usma.edu NR 24 TC 11 Z9 12 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1064-8011 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD DEC PY 2009 VL 23 IS 9 BP 2477 EP 2486 DI 10.1519/JSC.0b013e3181b1ae5f PG 10 WC Sport Sciences SC Sport Sciences GA 531RM UT WOS:000272685600008 PM 19910827 ER PT J AU Kerksick, CM Wilborn, CD Campbell, WI Harvey, TM Marcello, BM Roberts, MD Parker, AG Byars, AG Greenwood, LD Almada, AL Kreider, RB Greenwood, M AF Kerksick, Chad M. Wilborn, Colin D. Campbell, William I. Harvey, Travis M. Marcello, Brandon M. Roberts, Mike D. Parker, Adam G. Byars, Allyn G. Greenwood, Lori D. Almada, Anthony L. Kreider, Richard B. Greenwood, Mike TI THE EFFECTS OF CREATINE MONOHYDRATE SUPPLEMENTATION WITH AND WITHOUT D-PINITOL ON RESISTANCE TRAINING ADAPTATIONS SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE supplements; exercise; performance; ergogenic; retention ID X-RAY ABSORPTIOMETRY; SKELETAL-MUSCLE; BODY-COMPOSITION; SIGNALING PATHWAYS; FOOTBALL PLAYERS; HUMANS; PERFORMANCE; TRANSPORT; HYDRATION; STRENGTH AB Kerksick, CM, Wilborn, CD, Campbell, WI, Harvey, TM, Marcello, BM, Roberts, MD, Parker, AG, Byars, AG, Greenwood, LD, Almada, AL, Kreider, RB, and Greenwood, M. The effects of creatine monohydrate supplementation with and without D-pinitol on resistance training adaptations. J Strength Cond Res 23(9): 2673-2682, 2009-Coingestion of D-pinitol with creatine (CR) has been reported to enhance creatine uptake. The purpose of this study was to evaluate whether adding D-pinitol to CR affects training adaptations, body composition, whole-body creatine retention, and/or blood safety markers when compared to CR ingestion alone after 4 weeks of resistance training. Twenty-four resistance trained males were randomly assigned in a double-blind manner to creatine + pinitol (CRP) or creatine monohydrate (CR) prior to beginning a supervised 4-week resistance training program. Subjects ingested a typical loading phase (i.e., 20 g/d(-1) for 5 days) before ingesting 5 g/d(-1) the remaining 23 days. Performance measures were assessed at baseline (T0), week 1 (T1), and week 4 (T2) and included 1 repetition maximum (1RM) bench press (BP), 1RM leg press (LP), isokinetic knee extension, and a 30-second Wingate anaerobic capacity test. Fasting blood and body composition using dual-energy x-ray absorptiometry (DEXA) were determined at T1 and T3. Data were analyzed by repeated measures analysis of variance (ANOVA). Creatine retention increased (p < 0.001) in both groups as a result of supplementation but was not different between groups (p > 0.05). Significant improvements in upper- and lower-body strength and body composition occurred in both groups. However, significantly greater increases in lean mass and fat-free mass occurred in the CR group when compared to CRP (p < 0.05). Adding D-pinitol to creatine monohydrate does not appear to facilitate further physiological adaptations while resistance training. Creatine monohydrate supplementation helps to improve strength and body composition while resistance training. Data from this study assist in determining the potential role the addition of D-pinitol to creatine may aid in facilitating training adaptations to exercise. C1 [Greenwood, Lori D.; Greenwood, Mike] Baylor Univ, Dept Hlth Human Performance & Recreat, Waco, TX 76798 USA. [Kerksick, Chad M.; Roberts, Mike D.] Univ Oklahoma, Hlth & Exercise Sci Dept, Norman, OK 73019 USA. [Kerksick, Chad M.] Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Endocrinol & Diabet Sect, Oklahoma City, OK 73190 USA. [Wilborn, Colin D.] Univ Mary Hardin Baylor, Dept Exercise & Sport Sci, Belton, TX USA. [Campbell, William I.] Univ S Florida, Sch Phys Educ & Exercise Sci, Tampa, FL USA. [Harvey, Travis M.] US Mil Acad, Ctr Phys Dev Excellence, West Point, NY 10996 USA. [Marcello, Brandon M.] Stanford Univ, Dept Athlet, Palo Alto, CA 94304 USA. [Parker, Adam G.] W Texas A&M Univ, Dept Sport & Exercise Sci, Canyon, TX USA. [Byars, Allyn G.] Angelo State Univ, Dept Kinesiol, San Angelo, TX 76909 USA. [Almada, Anthony L.] IMAGINutrition Inc, Laguna Niguel, CA USA. [Kreider, Richard B.] Texas A&M Univ, Dept Hlth & Kinesiol, College Stn, TX USA. RP Greenwood, M (reprint author), Baylor Univ, Dept Hlth Human Performance & Recreat, Waco, TX 76798 USA. EM Mike_Greenwood@baylor.edu RI Kerksick, Chad/G-9059-2013; Kreider, Richard/O-1804-2014 OI Kerksick, Chad/0000-0003-0458-7294; Kreider, Richard/0000-0002-3906-1658 FU iSatori Global Technologies FX We would like to thank iSatori Global Technologies for funding this project. We would also like to thank all of the lab personnel in the Exercise and Sport Nutrition Laboratory at Baylor University who helped with the various aspects of collecting and analyzing the data in this study. Publication of this article does not constitute endorsement by the NSCA, the authors, and/or any of the authors' respective professional affiliations regarding the supplemental products provided by iSatori and administered in this investigation. NR 31 TC 9 Z9 11 U1 1 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1064-8011 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD DEC PY 2009 VL 23 IS 9 BP 2673 EP 2682 DI 10.1519/JSC.0b013e3181b3e0de PG 10 WC Sport Sciences SC Sport Sciences GA 531RM UT WOS:000272685600035 PM 19858753 ER PT J AU Brungart, DS Simpson, BD AF Brungart, Douglas S. Simpson, Brian D. TI Effects of bandwidth on auditory localization with a noise masker SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article DE acoustic noise; acoustic signal processing; hearing ID SOUND LOCALIZATION; PLANE AB Although high-frequency content is known to be critically important for the accurate location of isolated sounds, relatively little is known about the importance of high-frequency spectral content for the localization of sounds in the presence of a masker. In this experiment, listeners were asked to identify the location of a pulsed-noise target in the presence of a randomly located continuous noise masker. Both the target and masker were low-pass filtered at one of eight cutoff frequencies ranging from 1 to 16 kHz, and the signal-to-noise ratio was varied from -12 to +12 dB. The results confirm the importance of high frequencies for the localization of isolated sounds, and show that high-frequency content remains critical in cases where the target sound is masked by a spatially separated masker. In fact, when two sources of the same level are randomly located in space, these results show that a decrease in stimulus bandwidth from 16 to 12 kHz might result in a 30% increase in overall localization error. C1 [Brungart, Douglas S.; Simpson, Brian D.] USAF, Res Lab, Wright Patterson AFB, OH 45433 USA. RP Brungart, DS (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. EM douglas.brungart@us.army.mil NR 15 TC 3 Z9 3 U1 0 U2 2 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD DEC PY 2009 VL 126 IS 6 BP 3199 EP 3208 DI 10.1121/1.3243309 PG 10 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 533QH UT WOS:000272838800044 PM 20000933 ER PT J AU McPhatter, LP Debboun, M AF McPhatter, Lee P. Debboun, Mustapha TI ATTRACTIVENESS OF BOTANICAL INFUSIONS TO OVIPOSITING CULEX QUINQUEFASCIATUS, CX. NIGRIPALPUS, AND CX. ERRATICUS IN SAN ANTONIO, TEXAS SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Gravid trap; organic infusion; oviposition attractant; Culex quinquefasciatus; Culex nigripalpus ID MOSQUITOS; TARSALIS; TRAPS AB Field experiments were conducted on the Fort Sam Houston Military Reservation, San Antonio, TX, in fall 2008 to observe the attractiveness of selected botanical infusions to ovipositing female mosquitoes. The following infusions were tested in Centers for Disease Control and Prevention gravid traps: Bermuda grass (Cynodon dactylon), oak leaf (Quercia virginiana), acacia leaf (Acacia schaffneri), rabbit chow (alfalfa pellets), and algae (Spirogyra sp.). Four (Bermuda, acacia, oak, and algae) of the 5 infusions were effective in collecting Culex quinquefasciatus, Cx. nigripalpus, and Cx. erraticus. Of the 4 infusions, Bermuda collected the greatest number of the mosquitoes sampled. Female Aedes albopictus mosquitoes were collected in moderate numbers during this study. C1 [McPhatter, Lee P.] Brooke Army Med Ctr, Dept Prevent Med, Ft Sam Houston, TX 78234 USA. [Debboun, Mustapha] USA, Med Zool Branch, Dept Prevent Hlth Serv, Acad Hlth Sci,Med Dept Ctr & Sch, Ft Sam Houston, TX 78234 USA. RP McPhatter, LP (reprint author), Brooke Army Med Ctr, Dept Prevent Med, Ft Sam Houston, TX 78234 USA. NR 9 TC 4 Z9 6 U1 0 U2 3 PU AMER MOSQUITO CONTROL ASSOC PI EATONTOWN PA P O BOX 234, EATONTOWN, NJ 07724-0234 USA SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD DEC PY 2009 VL 25 IS 4 BP 508 EP 510 DI 10.2987/09-5930.1 PG 3 WC Entomology SC Entomology GA 536FM UT WOS:000273029300016 PM 20099599 ER PT J AU Walilko, T North, C Young, LA Lux, WE Warden, DL Jaffee, MS Moore, DF AF Walilko, Timothy North, Carol Young, Lee Ann Lux, Warren E. Warden, Deborah L. Jaffee, Michael S. Moore, David F. TI Head Injury as a PTSD Predictor Among Oklahoma City Bombing Survivors SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Posttraumatic stress disorder; Head injury; Injury correlation ID POSTTRAUMATIC-STRESS-DISORDER; TRAUMATIC BRAIN-INJURY AB Background: The aim of the Oklahoma City (OKC) bombing retrospective review was to investigate the relationship between physical injury, environmental contributors, and psychiatric disorders such as posttraumatic stress disorder (PTSD) in an event-based, matched design study focused on injury. Methods: The 182 selected participants were a random subset of the 1,092 direct survivors from the OKC bombing. Only 124 of these 182 cases had a full complement of medical/clinical data in the OKC database. These 124 cases were assessed to explore relationships among PTSD diagnoses, levels of blast exposure, and physical injuries. Associations among variables were statistically tested using contingency analysis and logistic regression. Results: Comparison of the PTSD cases to symptoms/diagnoses reported in the medical records reveals a statistically significant association between PTSD and head/brain injuries associated with head acceleration. PTSD was not highly correlated with other injuries. Although blast pressure and impulse were highly correlated with head injuries, the correlation with PTSD was not statistically significant. Thus, a correlation between blast pressure and PTSD may exist, but higher fidelity pressure calculations are required to elucidate this potential relationship. Conclusions: This study provides clear evidence that head injury is associated with subsequent PTSD, giving caregivers' information on what physical injuries may suggest the development of psychologic disorders to aid them in developing a profile for the identification of future survivors of terrorist attacks and Warfighters with brain injuries and potential PTSD. C1 [Warden, Deborah L.; Jaffee, Michael S.; Moore, David F.] Walter Reed Army Med Ctr, DVBIC, HQ, Washington, DC 20012 USA. [Walilko, Timothy; Young, Lee Ann] Appl Res Associates, San Antonio, TX USA. [North, Carol] VA N Texas Hlth Care Syst, Dept Psychiat, Dallas, TX USA. [North, Carol] Univ Texas SW Med Ctr Dallas, Div Emergency Med, Dept Psychiat & Surg, Dallas, TX 75390 USA. [Lux, Warren E.] US EPA, Washington, DC 20460 USA. RP Moore, DF (reprint author), Walter Reed Army Med Ctr, DVBIC, HQ, Room B207,Bldg 1,6900 Georgia Ave NW, Washington, DC 20012 USA. EM david.f.moore@amedd.army.mil FU Henry M. Jackson Foundation [0000104862] FX Supported by the Henry M. Jackson Foundation contract No. 0000104862 for the Defense and Veterans Brain Injury Center. NR 19 TC 11 Z9 11 U1 1 U2 15 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD DEC PY 2009 VL 67 IS 6 BP 1311 EP 1319 DI 10.1097/TA.0b013e31819adc36 PG 9 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 531IL UT WOS:000272658100038 PM 20009683 ER PT J AU Rice, KR Furusato, B Chen, YM McLeod, DG Sesterhenn, IA Brassell, SA AF Rice, Kevin R. Furusato, Bungo Chen, Yongmei McLeod, David G. Sesterhenn, Isabell A. Brassell, Stephen A. TI Clinicopathological Behavior of Single Focus Prostate Adenocarcinoma SO JOURNAL OF UROLOGY LA English DT Article DE prostate; prostatic neoplasms; neoplasm recurrence, local; prostatectomy; outcome assessment (health care) ID RADICAL PROSTATECTOMY; NEEDLE-BIOPSY; CANCER; THERAPY; SPECIMEN; FEATURES; VOLUME AB Purpose: With the increasing use of focal therapy for prostate adenocarcinoma a pathological basis for its appropriate application must be established. We determined the clinicopathological characteristics and natural history of single focus prostate cancer since this entity seems to be the ideal target for focal therapy. Materials and Methods: We queried the Center for Prostate Disease Research database for all patients who underwent radical prostatectomy at Walter Reed Army Medical Center from 1993 through 2008. Patients with single focus prostate adenocarcinoma were compared with those who had multifocal disease. Primary outcomes were surgical margin status, pathological stage and biochemical recurrence. Secondary outcomes were Gleason score and total tumor volume. Results: A total of 1,159 men were included in the study. Multifocal disease was present in 1,056 patients (99.1%) and 103 (8.9%) had single focus disease. There were statistically higher rates of positive surgical margins (41.0% vs 29.9%, p = 0.0012), Gleason score 8-10 disease (18.7% vs 10.1%, p = 0.0362) and biochemical recurrence (38.5% vs 24.2%, p = 0.0021) in the single focus and multifocal groups, respectively. The single focus group had significantly worse biochemical recurrence-free survival compared to the multifocal group (p = 0.0017). Conclusions: Single focus prostate cancer appears to have more aggressive behavior than multifocal disease. These findings support an aggressive, disciplined pretreatment evaluation to define disease site, extent and grade before focal therapy. C1 [Rice, Kevin R.; McLeod, David G.; Brassell, Stephen A.] Walter Reed Army Med Ctr, Urol Serv, Washington, DC 20307 USA. [Furusato, Bungo; Sesterhenn, Isabell A.] Armed Forces Inst Pathol, Dept Genitourinary Pathol, Washington, DC 20306 USA. [Furusato, Bungo; Chen, Yongmei; McLeod, David G.; Brassell, Stephen A.] Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, Bethesda, MD 20814 USA. RP Rice, KR (reprint author), 6900 Georgia Ave NW,Bldg 2,Ward 56, Washington, DC 20307 USA. EM Kevin.rice@amedd.army.mil OI Furusato, Bungo/0000-0003-4614-9882 NR 17 TC 12 Z9 12 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 J9 J UROLOGY JI J. Urol. PD DEC PY 2009 VL 182 IS 6 BP 2689 EP 2694 DI 10.1016/j.juro.2009.08.055 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA 518CU UT WOS:000271668600055 PM 19836800 ER PT J AU Sames, WJ Klein, TA Kim, HC Chong, ST Lee, IY Gu, SH Park, YM Jeong, JH Song, JW AF Sames, William J. Klein, Terry A. Kim, Heung Chul Chong, Sung Tae Lee, In Yong Gu, Se Hun Park, Yon Mi Jeong, Ji Hye Song, Jin-Won TI Ecology of Hantaan virus at Twin Bridges Training Area, Gyeonggi Province, Republic of Korea, 2005-2007 SO JOURNAL OF VECTOR ECOLOGY LA English DT Article DE Hantavirus; rodent; insectivores; ecology; Korea; Apodemus agrarius ID SIN-NOMBRE-VIRUS; RODENT POPULATIONS; SEOUL AB The Twin Bridges Training Area (TBTA) in the Republic of Korea consists of dirt roads, barren training areas, and forested hillsides adjacent to linear and broad expanses of tall grasses, herbaceous, and scrub vegetation. Of the six species of small mammals, the striped field mouse, Apodemus agrarius, was the most frequently captured (96.1%). Apodemus agrarius capture rates varied from 17.7 to 33.2% during three trapping periods. Gravid females were observed during November-December 2006 (8.4%) and March 2007 (5.1%). In 2005, the overall seroprevalence of Hantaan virus (HTNV) was high (34.4%) and lower during surveys in 2006 (14.2%) and 2007 (13.8%). Seroprevalence was directly correlated with weight increase of A. agrarius. C1 [Gu, Se Hun; Park, Yon Mi; Jeong, Ji Hye; Song, Jin-Won] Korea Univ, Inst Viral Dis, Coll Med, Dept Microbiol, Seoul, South Korea. [Sames, William J.] Def Logist Agcy, Ft Belvoir, VA 22060 USA. [Klein, Terry A.] USA, Unit 15281, MEDDAC Korea, APO, AP 96205 USA. [Kim, Heung Chul; Chong, Sung Tae] USA, Unit 15247, MEDDAC Korea, APO, AP 96205 USA. [Lee, In Yong] Yonsei Univ, Coll Med, Dept Environm Med Biol, Seoul 120749, South Korea. RP Song, JW (reprint author), Korea Univ, Inst Viral Dis, Coll Med, Dept Microbiol, 126-1,5Ga, Seoul, South Korea. RI Valle, Ruben/A-7512-2013 FU Armed Forces Health Surveillance Center (AFHSC); Global Emerging Infections Surveillance and Response System (GEIS); Silver Spring, MD; National Center for Medical Intelligence, Fort Detrick, MD FX We acknowledge the assistance of Kerry McKinley and the commanders and soldiers of the 5th and 38th Preventive Medicine Detachments, 168th Multifunctional Medical Battalion, 65th Medical Brigade for their support in coordinating and conducting rodent-borne disease surveillance. We thank Dr. Kyu-Ha Park for his support in identifying plant species collected at TBTA and Ms. Suk-Hee Yi for graphical and data analysis. We especially thank the graduate students and staff of Korea University for their support in the handling and gathering of small mammal bionomics in the laboratory. We also thank Dr. Joel Gaydos and Dr. Clara Witt, Armed Forces Health Surveillance Center (AFHSC), Global Emerging Infections Surveillance and Response Systems (GEIS), for their support in conducting this work. We are grateful for the support and encouragement that the 18th MEDCOM Commander, Brian Allgood (deceased), and Preventive Medicine Consultant, Hee-Choon Lee, provided throughout this study. Funding for portions of this work was provided by the Armed Forces Health Surveillance Center (AFHSC), Global Emerging Infections Surveillance and Response System (GEIS), Silver Spring, MD, and the National Center for Medical Intelligence, Fort Detrick, MD. Opinions and assertions are the views of the authors and are not to be construed as official, or as the official policy or position of the Department of Defense, the Department of the Army, or the U.S. Government. NR 22 TC 7 Z9 7 U1 0 U2 1 PU SOC VECTOR ECOLOGY PI CORONA PA 1966 COMPTON AVE, CORONA, CA 92881 USA SN 1081-1710 J9 J VECTOR ECOL JI J. Vector Ecol. PD DEC PY 2009 VL 34 IS 2 BP 225 EP 231 PG 7 WC Entomology SC Entomology GA 531GA UT WOS:000272650600008 PM 20836826 ER PT J AU Lee, IY Kim, HC Lee, YS Seo, JH Lim, JW Yong, TS Klein, TA Lee, WJ AF Lee, In Yong Kim, Heung Chul Lee, Young-Sun Seo, Jang Hoon Lim, Jae Won Yong, Tae Soon Klein, Terry A. Lee, Won Ja TI Geographical Distribution and Relative Abundance of Vectors of Scrub Typhus in the Republic of Korea SO KOREAN JOURNAL OF PARASITOLOGY LA English DT Article DE Leptotrombidium; chigger mites; geographical distribution; scrub typhus ID TSUTSUGAMUSHI; CHIGGERS AB A survey to determine the geographical distribution and relative abundance of potential vectors of scrub typhus was conducted from October to November 2006 at 13 localities throughout the Republic of Korea. Apodemus agrarius accounted for 97.6% (80/82) of all rodents, while only 2 Myodes regulus (2/82) were collected. A total of 10,860 chiggers were collected from A. agrarius belonging to 4 genera and 8 species, while only Walchia fragilis (40) was collected from Myodes regulus. Leptotrombidium pallidum (8,137; 74.9%), a vector of scrub typhus, was the predominant species collected from A. agrarius followed by Leptotrombidium scutellare (2,057, 18.9%), Leptotrombidium palpale (279; 2.7%), Leptotrombidium orientale (232; 2.1%), and Leptotrombidium zetum (79; 0.7%), Neotrombicula tamiyai (58; 0.5%), Euschoengastica koreaensis (16; 0.1%), and Cheladonta ikaoensis (2; < 0.1%). L. pallidum was the predominant chigger collected at collection sites in Gangwon (100%), Gyeonggi (87.2%), Chungnam (100%), Chungbuk (100%), Jeonbuk (73.9%), Jeonnam (77.0%), and Gyeongbuk (66.1%) provinces, whereas L. scutellare was the predominant chigger collected in Gyeongnam province (77.9%) and Jeju Island (62.3%). Data suggest a correlation between chigger population abundance and human cases of scrub typhus in Korea. C1 [Lee, Won Ja] Natl Inst Hlth, Div Med Entomol, Korea Ctr Dis Control & Prevent, Seoul 122701, South Korea. [Lee, In Yong; Yong, Tae Soon] Yonsei Univ, Coll Med, Dept Environm Med Biol, Seoul 120752, South Korea. [Kim, Heung Chul] Unit 15247, APO, AP 96205 USA. [Lee, Young-Sun] Suncheon Si Hlth Serv Ctr, Sunchon 540972, South Korea. [Seo, Jang Hoon] Shinheung Coll, Dept Clin Pathol, Uijongbu 480701, South Korea. [Lim, Jae Won] Natl Inst Biol Resources, Inchon 404708, South Korea. [Klein, Terry A.] US Army MEDDAC Korea, Unit 15281, APO, AP 96205 USA. RP Lee, WJ (reprint author), Natl Inst Hlth, Div Med Entomol, Korea Ctr Dis Control & Prevent, Seoul 122701, South Korea. EM wonja@nih.go.kr RI Valle, Ruben/A-7512-2013 FU Armed Forces Health Surveillance Center; Global Emerging Infections Surveillance and Response System; Silver Spring, Maryland, USA FX This work was supported by the Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response System, Silver Spring, Maryland, USA. NR 17 TC 19 Z9 19 U1 0 U2 3 PU KOREAN SOC PARASITOLOGY, SEOUL NATL UNIV COLL MEDI PI SEOUL PA DEPT PARASITOLOGY, SEOUL, 00000, SOUTH KOREA SN 0023-4001 J9 KOREAN J PARASITOL JI Korean J. Parasitol. PD DEC PY 2009 VL 47 IS 4 BP 381 EP 386 DI 10.3347/kjp.2009.47.4.381 PG 6 WC Parasitology SC Parasitology GA 533KK UT WOS:000272822300008 PM 19967086 ER PT J AU Friedrich, TL Vessey, WB Schuelke, MJ Ruark, GA Mumford, MD AF Friedrich, Tamara L. Vessey, William B. Schuelke, Matthew J. Ruark, Gregory A. Mumford, Michael D. TI A framework for understanding collective leadership: The selective utilization of leader and team expertise within networks SO LEADERSHIP QUARTERLY LA English DT Review DE Collective leadership; Network; Expertise; Shared leadership; Distributed leadership ID MEMBER EXCHANGE; SHARED LEADERSHIP; GROUP-PERFORMANCE; ORGANIZATIONAL PERFORMANCE; RELATIONAL LEADERSHIP; MULTISOURCE FEEDBACK; EMPLOYEE REACTIONS; MANAGEMENT TEAMS; DECISION-MAKING; SOCIAL NETWORKS AB To date, the dominant approach to leadership research assumes that all aspects of the leadership role within a team are embodied by a single individual. In the real world, however. this is rarely the case. Rather, multiple individuals within the team may serve as leaders in both formal and informal capacities, and the shifting of leadership responsibilities is often rooted in which individual's expertise is most relevant to the given problem. In the present effort, we add to the rapidly growing body of work that focuses on the distribution of the leadership role among multiple individuals. We have reviewed relevant extant literature and proposed an integrated framework for understanding the collective leadership process. Also, in developing this framework we have taken an information and expertise-based approach such that we propose that collective leadership, or the distribution of the leadership role. is a function of selectively utilizing the information or specialized expertise that individuals within the network possess. In reviewing the framework, 55 propositions with regard to the collective leadership process are outlined and suggestions for future research are provided. (C) 2009 Elsevier Inc. All rights reserved. C1 [Friedrich, Tamara L.; Vessey, William B.; Schuelke, Matthew J.; Mumford, Michael D.] Univ Oklahoma, Norman, OK 73019 USA. [Ruark, Gregory A.] USA, Res Inst, Washington, DC 20310 USA. RP Friedrich, TL (reprint author), Univ Oklahoma, Norman, OK 73019 USA. EM tfriedrich@psychology.ou.edu NR 121 TC 64 Z9 66 U1 12 U2 80 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1048-9843 J9 LEADERSHIP QUART JI Leadersh. Q. PD DEC PY 2009 VL 20 IS 6 BP 933 EP 958 DI 10.1016/j.leaqua.2009.09.008 PG 26 WC Psychology, Applied; Management SC Psychology; Business & Economics GA 524AX UT WOS:000272117300006 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Last Train from Hiroshima: The Survivors Look Back. SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD DEC PY 2009 VL 134 IS 20 BP 120 EP 121 PG 2 WC Information Science & Library Science SC Information Science & Library Science GA 530IZ UT WOS:000272584300123 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Hitler's Army: The Men, Machines and Organization: 1939-1945 SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD DEC PY 2009 VL 134 IS 20 BP 121 EP 121 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 530IZ UT WOS:000272584300126 ER PT J AU Jin, X Mukherjee, K Gupta, S Ray, A Phoha, S Damarla, T AF Jin, Xin Mukherjee, Kushal Gupta, Shalabh Ray, Asok Phoha, Shashi Damarla, Thyagaraju TI Asynchronous data-driven classification of weapon systems SO MEASUREMENT SCIENCE AND TECHNOLOGY LA English DT Article DE weapon systems; pattern classification; symbolic dynamic filtering; language measure; support vector machine ID REGULAR LANGUAGES AB This communication addresses real-time weapon classification by analysis of asynchronous acoustic data, collected from microphones on a sensor network. The weapon classification algorithm consists of two parts: (i) feature extraction from time-series data using symbolic dynamic filtering (SDF), and (ii) pattern classification based on the extracted features using the language measure (LM) and support vector machine (SVM). The proposed algorithm has been tested on field data, generated by firing of two types of rifles. The results of analysis demonstrate high accuracy and fast execution of the pattern classification algorithm with low memory requirements. Potential applications include simultaneous shooter localization and weapon classification with soldier-wearable networked sensors. C1 [Jin, Xin; Mukherjee, Kushal; Gupta, Shalabh; Ray, Asok; Phoha, Shashi] Penn State Univ, University Pk, PA 16802 USA. [Damarla, Thyagaraju] USA, Res Lab, Adelphi, MD 20783 USA. RP Jin, X (reprint author), Penn State Univ, University Pk, PA 16802 USA. EM xuj103@psu.edu; kum162@psu.edu; szg107@psu.edu; axr2@psu.edu; sxp26@psu.edu; rdamarla@arl.army.mil RI Jin, Xin/H-5022-2012 FU US Army Research Laboratory; US Army Research Office [W911NF-07-1-0376]; US Office of Naval Research [N00014-09-1-0688]; NASA [NNX07AK49A] FX This work was supported in part by the US Army Research Laboratory and the US Army Research Office under Grant No. W911NF-07-1-0376, by the US Office of Naval Research under Grant No. N00014-09-1-0688, and by NASA under Cooperative Agreement No. NNX07AK49A. Any opinions, findings and conclusions or recommendations expressed in this publication are those of the authors and do not necessarily reflect the views of the sponsoring agencies. NR 17 TC 3 Z9 3 U1 0 U2 4 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0957-0233 EI 1361-6501 J9 MEAS SCI TECHNOL JI Meas. Sci. Technol. PD DEC PY 2009 VL 20 IS 12 AR 123001 DI 10.1088/0957-0233/20/12/123001 PG 6 WC Engineering, Multidisciplinary; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 521DP UT WOS:000271900500002 ER PT J AU Gavula, MBP AF Gavula, Major Brian P. TI LOCKING DOWN PRETRIAL CONFINEMENT REVIEW: AN ARGUMENT FOR REALIGNING RCM 305 WITH THE CONSTITUTION SO MILITARY LAW REVIEW LA English DT Article ID MILITARY C1 [Gavula, Major Brian P.] USA, Washington, DC USA. RP Gavula, MBP (reprint author), Judge Advocate Gens Legal Ctr & Sch, Ctr Law & Mil Operat, Charlottesville, VA USA. NR 42 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2009 VL 202 BP 1 EP 52 PG 52 WC Law SC Government & Law GA 571HR UT WOS:000275743400001 ER PT J AU Barnsby, MRE AF Barnsby, Major Robert E. TI YES, WE CAN: THE AUTHORITY TO DETAIN AS CUSTOMARY INTERNATIONAL LAW SO MILITARY LAW REVIEW LA English DT Article C1 USA, TJAGLCS, Intl & Operat Law Dept, Charlottesville, VA USA. RP Barnsby, MRE (reprint author), USA, TJAGLCS, Intl & Operat Law Dept, Charlottesville, VA USA. NR 34 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2009 VL 202 BP 53 EP 90 PG 38 WC Law SC Government & Law GA 571HR UT WOS:000275743400002 ER PT J AU Seamone, CER AF Seamone, Captain Evan R. TI ATTORNEYS AS FIRST-RESPONDERS: RECOGNIZING THE DESTRUCTIVE NATURE OF POSTTRAUMATIC STRESS DISORDER ON THE COMBAT VETERAN'S LEGAL DECISION-MAKING PROCESS SO MILITARY LAW REVIEW LA English DT Article ID MILITARY; THERAPY; WAR; AFGHANISTAN; IMPACT; PTSD; DUTY; IRAQ; LAW C1 [Seamone, Captain Evan R.] USA, Washington, DC USA. RP Seamone, CER (reprint author), Judge Advocate Gens Legal Ctr & Sch, Charlottesville, VA USA. NR 156 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2009 VL 202 BP 144 EP 184 PG 41 WC Law SC Government & Law GA 571HR UT WOS:000275743400004 ER PT J AU Seamone, CER AF Seamone, Captain Evan R. TI THE VETERANS' LAWYER AS COUNSELOR: USING THERAPEUTIC JURISPRUDENCE TO ENHANCE CLIENT COUNSELING FOR COMBAT VETERANS WITH POSTTRAUMATIC STRESS DISORDER SO MILITARY LAW REVIEW LA English DT Article C1 [Seamone, Captain Evan R.] USA, Washington, DC USA. RP Seamone, CER (reprint author), Judge Advocate Gens Legal Ctr & Sch, Charlottesville, VA USA. NR 118 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2009 VL 202 BP 185 EP 257 PG 73 WC Law SC Government & Law GA 571HR UT WOS:000275743400005 ER PT J AU Ching, MAB AF Ching, Major Ann B. TI 7 DEADLY SCENARIOS SO MILITARY LAW REVIEW LA English DT Book Review C1 [Ching, Major Ann B.] USA, Judge Advocate Officer Grad Course 58, Judge Advocate Gens Legal Ctr & Sch, Charlottesville, VA USA. RP Ching, MAB (reprint author), USA, Judge Advocate Officer Grad Course 58, Judge Advocate Gens Legal Ctr & Sch, Charlottesville, VA USA. NR 20 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2009 VL 202 BP 283 EP 290 PG 8 WC Law SC Government & Law GA 571HR UT WOS:000275743400007 ER PT J AU Neuhauser, MJA AF Neuhauser, Major Jennifer A. TI THE TOKYO WAR CRIMES TRIAL: THE PURSUIT OF JUSTICE IN THE WAKE OF WORLD WAR II SO MILITARY LAW REVIEW LA English DT Book Review C1 [Neuhauser, Major Jennifer A.] USA, Judge Advocate Officer Grad Course 58, Judge Advocate Gens Legal Ctr & Sch, Charlottesville, VA USA. RP Neuhauser, MJA (reprint author), USA, Judge Advocate Officer Grad Course 58, Judge Advocate Gens Legal Ctr & Sch, Charlottesville, VA USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2009 VL 202 BP 291 EP 298 PG 8 WC Law SC Government & Law GA 571HR UT WOS:000275743400008 ER PT J AU Bolesh, DT AF Bolesh, David T. TI Untitled SO MILITARY MEDICINE LA English DT Letter C1 USA, Kenner Army Hlth Clin, Washington, DC 20310 USA. RP Bolesh, DT (reprint author), USA, Kenner Army Hlth Clin, Washington, DC 20310 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2009 VL 174 IS 12 BP VI EP VII PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 601LM UT WOS:000278061000004 PM 20055052 ER PT J AU Himmler, B AF Himmler, Bruno TI Health Care Diplomacy: The Iraq Experience and How It Can Shape the Future SO MILITARY MEDICINE LA English DT Editorial Material C1 USA, War Coll, Peacekeeping & Stabil Operat Inst, Carlisle, PA 17013 USA. RP Himmler, B (reprint author), USA, War Coll, Peacekeeping & Stabil Operat Inst, Upton Hall,22 Ashburn Dr, Carlisle, PA 17013 USA. NR 7 TC 2 Z9 2 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2009 VL 174 IS 12 BP XVIII EP XX PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 601LM UT WOS:000278061000016 PM 20055061 ER PT J AU Nieves, JE Candelario, J Short, D Briscoe, G AF Nieves, J. Edwin Candelario, Joseph Short, Delmar Briscoe, Gregory TI Telemental Health for Our Soldiers: A Brief Review and a New Pilot Program SO MILITARY MEDICINE LA English DT Review C1 [Nieves, J. Edwin] ACOS, Educ & Res, Hampton, VA 23667 USA. [Candelario, Joseph] USA, Womack Army Med Ctr, FNP BC, Ft Bragg, NC 28310 USA. [Short, Delmar] VA Med Ctr, Chief MHBSS 116A, Salem, VA 24153 USA. RP Nieves, JE (reprint author), ACOS, Educ & Res, 100 Emancipat Dr, Hampton, VA 23667 USA. NR 5 TC 6 Z9 6 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2009 VL 174 IS 12 BP XXI EP XXII PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 601LM UT WOS:000278061000017 PM 20055062 ER PT J AU Thorkildson, RM Jones, KF Emery, MK AF Thorkildson, Ronald M. Jones, Kathleen F. Emery, Maggie K. TI In-Cloud Icing in the Columbia Basin SO MONTHLY WEATHER REVIEW LA English DT Article AB On 24 November 2005, 11 lattice steel towers of a high-voltage electrical transmission line running along the edge of an escarpment were damaged by an accumulation of rime on overhead ground wires. Cold air pooling in the Columbia basin of eastern Washington several days before the failure led to the formation of low-level fog and low clouds with temperatures below freezing at the elevation of the transmission line. The liquid water content profile of the cloud formed by air rising over Badger Mountain north of Wenatchee, Washington, is estimated using the air temperature, dewpoint temperature, and air pressure as measured at Wenatchee in the Columbia River valley below the line. Cloud median volume droplet diameters are estimated using typical droplet concentrations. The validity of the computed liquid water content is determined by comparing the measured cloud-base heights at Wenatchee with the calculated cloud-base heights. The mass and density of ice accreted on the ground wires and conductors of the transmission line are modeled using assumed wind speeds at the top of the escarpment with the estimated cloud properties. Results are compared with the density and mass of an ice sample retrieved from the field. This event is compared with other modeled in-cloud icing events from 1973 to 2007 using the period of record of Wenatchee weather data. This paper illustrates an approach for estimating the severity of in-cloud icing on the wires of transmission lines subject to cloud liquid water contents that have been enhanced by the local terrain. C1 [Jones, Kathleen F.] Cold Reg & Engn Lab, Hanover, NH USA. [Emery, Maggie K.] Bonneville Power Adm Transmiss Serv, Vancouver, WA USA. RP Thorkildson, RM (reprint author), 14450 Mt View Loop, Sisters, OR 97759 USA. EM rthorkildson@bendbroadband.com FU Bonneville Power Administration FX This work was supported by the Bonneville Power Administration. We thank Dr. George Koenig of CRREL for helpful discussions and Brian Tracy of CRREL for acquiring satellite imagery of the cloud coverage. We appreciate the valuable input provided by the anonymous reviewers. NR 14 TC 8 Z9 10 U1 0 U2 1 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0027-0644 J9 MON WEATHER REV JI Mon. Weather Rev. PD DEC PY 2009 VL 137 IS 12 BP 4369 EP 4381 DI 10.1175/2009MWR2941.1 PG 13 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 543GT UT WOS:000273562700018 ER PT J AU Hurst, FP Neff, RT Jindal, RM Roberts, JR Lentine, KL Agodoa, LY Abbott, KC AF Hurst, Frank P. Neff, Robert T. Jindal, Rahul M. Roberts, Jefferson R. Lentine, Krista L. Agodoa, Lawrence Y. Abbott, Kevin C. TI Incidence, predictors and associated outcomes of rhabdomyolysis after kidney transplantation SO NEPHROLOGY DIALYSIS TRANSPLANTATION LA English DT Article DE 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors; calcineurin inhibitors; renal transplantation; rhabdomyolysis; USRDS ID SICKLE-CELL TRAIT; CERIVASTATIN-INDUCED RHABDOMYOLYSIS; RENAL-TRANSPLANT; PATIENT; CYCLOSPORINE; SIMVASTATIN; TACROLIMUS; RECIPIENTS; ATORVASTATIN; THERAPY AB Background. There are several case reports of rhabdomyolysis (RM) in renal transplant recipients, but the actual incidence of this complication is not known. Most of the reported cases have been attributed to drug-drug interactions with calcineurin inhibitors, with the majority of interactions reported between cyclosporine and 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins). Pharmacokinetic studies have demonstrated that cyclosporine increases statin drug levels, presumably via competitive inhibition of cytochrome P450 3A4. Methods. In a retrospective cohort of 20 366 adult Medicare primary renal transplant recipients in the USRDS database transplanted from 1 January 2003 to 31 July 2005 and followed through 31 December 2005, we assessed Medicare claims for RM and dyslipidaemia (HPL), which was used as a surrogate for statin use. Results. The incidence rate of RM post-transplant for the study period was 1.4 (95% CI 1.1-1.8) per 1000 person-years. By Cox regression analysis, cyclosporine (versus tacrolimus) use [AHR 2.36 (95% CI 1.23-4.35); P=0.006] and black race [AHR 2.33 (95% CI 1.30-4.17); P = 0.005] were associated with RM. By Cox non-proportional hazards regression, RM was associated with graft loss (including death) [AHR 2.84 (95% CI 1.70-4.72); P < 0.001]. Conclusions. RM is a rare complication after renal transplantation and is significantly associated with allograft loss (including death). RM is significantly more likely to occur with cyclosporine (versus tacrolimus)-based immunosuppression and possibly in persons of black race. Increased surveillance for RM is warranted in these at-risk patients. C1 [Hurst, Frank P.; Neff, Robert T.; Abbott, Kevin C.] Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. [Hurst, Frank P.; Neff, Robert T.; Roberts, Jefferson R.; Abbott, Kevin C.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. [Jindal, Rahul M.] Walter Reed Army Med Ctr, Organ Transplant Serv, Washington, DC 20307 USA. [Roberts, Jefferson R.] Walter Reed Army Med Ctr, Rheumatol Serv, Washington, DC 20307 USA. [Lentine, Krista L.] St Louis Univ, Sch Med, Div Nephrol, Ctr Outcomes Res, St Louis, MO USA. [Agodoa, Lawrence Y.] NIDDK, NIH, Bethesda, MD USA. RP Hurst, FP (reprint author), Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. EM frank.hurst@us.army.mil OI Abbott, Kevin/0000-0003-2111-7112 NR 33 TC 13 Z9 13 U1 0 U2 1 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0931-0509 J9 NEPHROL DIAL TRANSPL JI Nephrol. Dial. Transplant. PD DEC PY 2009 VL 24 IS 12 BP 3861 EP 3866 DI 10.1093/ndt/gfp416 PG 6 WC Transplantation; Urology & Nephrology SC Transplantation; Urology & Nephrology GA 524ZR UT WOS:000272183400051 PM 19729463 ER PT J AU Hofstra, DE Edwards, T Clayton, JS Shearer, JF AF Hofstra, Deborah E. Edwards, Tracey Clayton, John S. Shearer, Judy F. TI New record of fungus Mycoleptodiscus terrestris from New Zealand SO NEW ZEALAND JOURNAL OF BOTANY LA English DT Article DE Ceratophyllum demersum; Hyphomycetes AB During a survey of submersed aquatic macrophytes and their associated fungi from lakes and waterways in New Zealand's North Island, an isolate of Mycoleptodiscus terrestris (Gerd.) Ostaz. was confirmed on the basis of colony characteristics, sporodochia, and conidial morphology. This is a new record of M. terrestris in New Zealand and a new host species, the introduced aquatic macrophyte, Ceratophyllum demersum L. C1 [Hofstra, Deborah E.; Edwards, Tracey; Clayton, John S.] Natl Inst Water & Atmospher Res, Hamilton 3251, New Zealand. [Shearer, Judy F.] USA, Corps Engineers, Ctr Res & Dev, Vicksburg, MS 39180 USA. RP Hofstra, DE (reprint author), Natl Inst Water & Atmospher Res, POB 11115, Hamilton 3251, New Zealand. EM D.Hofstra@niwa.co.nz NR 17 TC 2 Z9 3 U1 0 U2 1 PU RSNZ PUBLISHING PI WELLINGTON PA PO BOX 598, WELLINGTON, 00000, NEW ZEALAND SN 0028-825X J9 NEW ZEAL J BOT JI N. Z. J. Bot. PD DEC PY 2009 VL 47 IS 4 BP 411 EP 415 DI 10.1080/0028825x.2009.9672716 PG 5 WC Plant Sciences SC Plant Sciences GA 545II UT WOS:000273725300005 ER PT J AU Brandt, HE AF Brandt, Howard E. TI Riemannian geometry of quantum computation SO NONLINEAR ANALYSIS-THEORY METHODS & APPLICATIONS LA English DT Article; Proceedings Paper CT 5th World Congress on Nonlinear Analysts CY JUL 02-09, 2008 CL Orlando, FL DE Quantum computing; Quantum circuits; Quantum complexity; Differential geometry; Riemannian geometry; Geodesics AB A review is given of some recent developments in the differential geometry of quantum computation for which the quantum evolution is described by the special unitary unimodular group, SU(2(n)). Using the Lie algebra su(2(n)), detailed derivations are given of a useful Riemannian geometry of SU(2(n)), including the connection and the geodesic equation for minimal complexity quantum computations. Published by Elsevier Ltd C1 USA, Res Lab, Adelphi, MD USA. RP Brandt, HE (reprint author), USA, Res Lab, Adelphi, MD USA. EM hbrandt@arl.army.mil NR 25 TC 5 Z9 5 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0362-546X J9 NONLINEAR ANAL-THEOR JI Nonlinear Anal.-Theory Methods Appl. PD DEC PY 2009 VL 71 IS 12 BP E474 EP E486 DI 10.1016/j.na.2008.11.013 PG 13 WC Mathematics, Applied; Mathematics SC Mathematics GA 597MY UT WOS:000277763200050 ER PT J AU Arntzen, EV Geist, DR Murray, KJ Vavrinec, J Dawley, EM Schwartz, DE AF Arntzen, Evan V. Geist, David R. Murray, Katherine J. Vavrinec, John Dawley, Earl M. Schwartz, Dennis E. TI Influence of the Hyporheic Zone on Supersaturated Gas Exposure to Incubating Chum Salmon SO NORTH AMERICAN JOURNAL OF FISHERIES MANAGEMENT LA English DT Article ID FALL CHINOOK SALMON; BUBBLE TRAUMA INCIDENCE; OXYGEN-NITROGEN RATIOS; REDD SITE SELECTION; COLUMBIA-RIVER; HYDRAULIC CONDUCTIVITY; SALVELINUS-NAMAYCUSH; STEELHEAD TROUT; GRAVEL-BED; LAKE TROUT AB Hydroelectric dam operation causes total dissolved gas (TDG) to be seasonally elevated in the lower Columbia River, as surface water concentrations approach 120%. Federally protected chum salmon Oncorhynchus keta embryos incubating in nearby spawning areas could be affected if depth-compensated TDG concentrations within the hyporheic zone exceed 103%. The objective of this study was to determine whether TDG of the hyporheic zone in two chum salmon spawning areas-one in a side channel near Ives Island, Washington, and another on the main-stem Columbia River near Multnomah Falls, Oregon-was affected by the elevated TDG of the surface water. Depth-compensated hyporheic TDG did not exceed 103% at the Multnomah Falls site. However, in the Ives Island area, chum salmon redds were exposed to TDG greater than 103% for more than 300 h. In response to river depth fluctuations, TDG varied significantly in the Ives Island area, suggesting increased interaction between the hyporheic zone and surface water at that site. We conclude from this study that the interaction between surface water and the hyporheic zone affects the concentration of TDG within the hyporheic zone directly via physical mixing and indirectly by altering water chemistry and thus dissolved gas solubility. Consideration of these interactions is important when estimating TDG exposure within egg pocket environments and will enable resource managers to optimize recovery strategies. C1 [Arntzen, Evan V.; Geist, David R.; Murray, Katherine J.] Pacific NW Natl Lab, Richland, WA 99352 USA. [Vavrinec, John] Pacific NW Natl Lab, Sequim, WA 98382 USA. [Dawley, Earl M.] Natl Ocean & Atmospher Adm, Astoria, OR 97103 USA. [Schwartz, Dennis E.] USA, Corps Engineers, Portland, OR 97204 USA. RP Arntzen, EV (reprint author), Pacific NW Natl Lab, POB 999, Richland, WA 99352 USA. EM evan.arntzen@pnl.gov FU USACE FX This study was funded by USACE through its Anadromous Fish Evaluation Program. Kathy McGrath and Kathleen Carter reviewed related literature. Berhon Dibrani, Jennifer Panther, and Cherylyn Tunnicliffe assisted with sensor calibration. Michael Blanton, Sue Southard, John Southard, Kathryn Sobocinski, and Kaitlin Hartman assisted with data collection. Pacific Northwest National Laboratory is operated by Battelle for the U.S. Department of Energy under Contract Number DE-AC05-76RL01830. Reference to trade names does not imply endorsement by the U.S. Government. NR 73 TC 7 Z9 7 U1 2 U2 9 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0275-5947 J9 N AM J FISH MANAGE JI North Am. J. Fish Manage. PD DEC PY 2009 VL 29 IS 6 BP 1714 EP 1727 DI 10.1577/M08-212.1 PG 14 WC Fisheries SC Fisheries GA 588ZQ UT WOS:000277113800019 ER PT J AU Maurer, T Wilson, DL Smith, SR Deaver, DM Flug, EA Nguyen, OT AF Maurer, Tana Wilson, David L. Smith, Stevie R. Deaver, Dawne M. Flug, Eric A. Nguyen, Oanh Tho TI Search and detection comparing midwave and longwave infrared (vol 48, 116401, 2009) SO OPTICAL ENGINEERING LA English DT Correction C1 [Maurer, Tana; Wilson, David L.; Smith, Stevie R.; Deaver, Dawne M.; Flug, Eric A.; Nguyen, Oanh Tho] USA, Res Dev & Engn Command, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Maurer, T (reprint author), USA, Res Dev & Engn Command, Night Vis & Elect Sensors Directorate, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SPIE-SOC PHOTOPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD DEC PY 2009 VL 48 IS 12 AR 129801 PG 1 WC Optics SC Optics GA 538VB UT WOS:000273211200031 ER PT J AU Lindsay, GA Davis, MC Chafin, AP Fallis, S Hoffman, RC Pritchett, TM Andzelm, J Rawlett, AM Park, D Herman, WN AF Lindsay, Geoffrey A. Davis, Matthew C. Chafin, Andrew P. Fallis, Stephen Hoffman, Robert C. Pritchett, Timothy M. Andzelm, Jan Rawlett, Adam M. Park, Dong Herman, Warren N. TI Electro-optic polymeric films of phenylethynyl dyes with transparency in the blue region of the visible spectrum SO OPTICAL MATERIALS LA English DT Article DE Electro-optic; Polymers; Transparent; First hyperpolarizability; Dyes; Nonlinear optic ID NONLINEAR-OPTICAL-PROPERTIES; BENZYLIDENE-ANILINE DERIVATIVES; MOLECULAR-BEAM HETEROEPITAXY; 2ND-HARMONIC GENERATION; MAIN-CHAIN; AROMATIC-COMPOUNDS; ELECTRIC-FIELD; WAVE-GUIDES; CHROMOPHORES; HYPERPOLARIZABILITIES AB Easily processed electro-optic films are reported with potential for >100 GHz switching speeds. Dyes of the general chemical structure 1-(4-[N-ethyl-N-(2-hydroxyethyl)-amino]-phenylethynyl)-4-(4-cyanophenylethynyl)-2,5-disubstituted benzene were attached as side groups to a polyimide backbone. Substituents on the central ring of the three-ring dye prevented aggregation at high concentrations of dye. These amorphous films exhibited absorption maxima in the range of 375-395 nm. A film containing 25% dye attached to polyimide was poled to give an electro-optic coefficient (r(33)) of 12 +/- 2 pm/V at 532 nm. Its properties were compared with the measured linear and nonlinear optical properties of several previously published dyes that have transparency in the blue-green part of the visible spectrum. Published by Elsevier B.V. C1 [Lindsay, Geoffrey A.; Davis, Matthew C.; Chafin, Andrew P.; Fallis, Stephen] USN, NAWCWD Res Dept, China Lake, CA 93555 USA. [Hoffman, Robert C.; Pritchett, Timothy M.] USA, Res Lab, AMSRD ARL SE EM, Adelphi, MD 20783 USA. [Andzelm, Jan; Rawlett, Adam M.] USA, Res Lab, AMSRD ARL WM MA, Aberdeen, MD 21005 USA. [Park, Dong; Herman, Warren N.] Univ Maryland, Lab Phys Sci, College Pk, MD 20740 USA. RP Lindsay, GA (reprint author), USN, NAWCWD Res Dept, C-4L4200D,MS 6303,1900 N Knox Rd, China Lake, CA 93555 USA. EM geoffrey.lindsay@navy.mil FU Army Research Laboratory, Office of Naval Research FX The authors are grateful for the sponsorship of the Army Research Laboratory, Office of Naval Research, and the encouragement provided by Andrew Mott (ARL). J. Orlicki (ARL) performed film processing, and D. Bliss (NAWCWD) performed DSC and GPC measurements. NR 65 TC 1 Z9 1 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0925-3467 EI 1873-1252 J9 OPT MATER JI Opt. Mater. PD DEC PY 2009 VL 32 IS 2 BP 302 EP 310 DI 10.1016/j.optmat.2009.08.008 PG 9 WC Materials Science, Multidisciplinary; Optics SC Materials Science; Optics GA 533GB UT WOS:000272810600008 ER PT J AU Hatch, BC Hilber, DJ Elledge, JB Stout, JW Lee, RB AF Hatch, Brian C. Hilber, David J. Elledge, James B. Stout, James W. Lee, Robyn B. TI The Effects of Visual Acuity on Target Discrimination and Shooting Performance SO OPTOMETRY AND VISION SCIENCE LA English DT Article DE visual acuity; target discrimination; target identification; military; firearms; reference standards; performance based; occupational status; vision readiness; ocular dominance; military personnel; marksmanship; occupational vision requirements; visual angle ID MARKSMANSHIP; MOOD AB Purpose. To explore the effects of visual acuity on target discrimination and marksmanship. Methods. A randomized, single-blind, repeated measures study was conducted to evaluate the effect of visual acuity on target discrimination and marksmanship. Subjects were examined for inclusion criteria and equivalent plus lens over-refractions necessary to obtain the five test visual acuity ranges. Qualified subjects fired at randomized target presentations from 50 to 300 m while wearing customized spectacles to yield the visual acuity levels being evaluated. Subjects then rotated foxholes for target discrimination sequences. Randomized targets marked as friend or enemy were presented in like manner for each of the five visual acuity levels. Results. Subjects at acuities better than 0.2 LogMAR were significantly more likely to hit the target than those with acuities equal to or worse than 0.7 LogMAR. Target discrimination results show subjects with acuities between -0.2 and 0.6 LogMAR were significantly more likely to correctly identify the target than those with acuities equal to or worse than 0.7 LogMAR. In addition, those at acuities of 0.0 LogMAR or better performed significantly better than those with acuities between 0.3 and 0.6 LogMAR. Conclusions. Visual acuity significantly affects target discrimination and marksmanship performance. Results of this study closely mirror expected findings based on visual angles with acuities in the range 0.3 to 0.4 LogMAR (20/40-20/50) being the transition zone where performance begins to deteriorate. This performance-based evidence fully supports a vision classification system that mandates eyewear to maximize visual performance for deployable military members. Based on the results of this study, the current U.S. Army, U.S. Navy, and U.S. Marine Corps vision readiness standards of 20/40 or better uncorrected or corrected vision seems to be a valid choice because it is the transition point for performance in both target discrimination and marksmanship ability. (Optom Vis Sci 2009;86:1359-1367) C1 [Hatch, Brian C.; Hilber, David J.; Elledge, James B.; Stout, James W.; Lee, Robyn B.] USA, Ctr Hlth Promot & Prevent Med, Tri Serv Vis Conservat & Readiness Program, Aberdeen Proving Ground, MD USA. RP Hatch, BC (reprint author), USN, Hosp Bremerton, Dept Optometry, 1 Boone Rd, Bremerton, WA 98312 USA. EM brian.hatch@med.navy.mil FU Health Promotion Prevention and Initiatives (HPPI) Program; Directorate of Occupational and EnvironmentalMedicine (DOEM) FX This study was supported by the Health Promotion Prevention and Initiatives (HPPI) Program and the Directorate of Occupational and EnvironmentalMedicine (DOEM), which are administeredby the U.S. Army Center for Health Promotion and Preventive Medicine. NR 20 TC 4 Z9 4 U1 2 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1040-5488 J9 OPTOMETRY VISION SCI JI Optom. Vis. Sci. PD DEC PY 2009 VL 86 IS 12 BP 1359 EP 1367 PG 9 WC Ophthalmology SC Ophthalmology GA 529EX UT WOS:000272499900007 ER PT J AU Overton, J AF Overton, J. TI Militia Myths Ideas of the Canadian Citizen Soldier, 1896-1921 SO PACIFIC NORTHWEST QUARTERLY LA English DT Book Review C1 [Overton, J.] USA, Western Reg Med Command, Washington, DC 20310 USA. RP Overton, J (reprint author), USA, Western Reg Med Command, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV WASHINGTON PI SEATTLE PA 4045 BROOKLYN AVENUE NE, SEATTLE, WA 98105 USA SN 0030-8803 J9 PAC NORTHWEST QUART JI Pac. Northwest Q. PD WIN PY 2009 VL 101 IS 1 BP 40 EP 41 PG 2 WC History SC History GA V16OR UT WOS:000207879400013 ER PT J AU Dibble, LE Hale, TF Marcus, RL Gerber, JP LaStayo, PC AF Dibble, Leland E. Hale, Tessa F. Marcus, Robin L. Gerber, J. Parry LaStayo, Paul C. TI High intensity eccentric resistance training decreases bradykinesia and improves quality of life in persons with Parkinson's disease: A preliminary study SO PARKINSONISM & RELATED DISORDERS LA English DT Article DE Parkinson's disease; Exercise; Eccentric; Resistance training; Bradykinesia; Quality of life ID GAIT; PERFORMANCE; PEOPLE; EXERCISE; BALANCE; REHABILITATION; QUESTIONNAIRE; FEASIBILITY; STRENGTH; THERAPY AB Persons with Parkinson disease (PD) often demonstrate bradykinesia during mobility tasks. Bradykinesia combined with other PD-related movement deficits may contribute to self-reported reductions in quality of life, At this time, no studies have examined the effects of resistance exercise as an intervention to reduce bradykinesia and improve self-reported quality of life. Therefore, we examined changes in muscle force production, clinical measures of bradykinesia, and quality of life following 12 weeks of a high intensity eccentric resistance exercise program in persons with mild to moderate PD. Twenty individuals with idiopathic PD were matched into an experimental or an active control group. All participants were tested prior to and following a 12-week intervention period. The experimental group performed high intensity quadriceps contractions on an eccentric ergometer 3 days a week for 12 weeks. The active control group participated in an evidence based exercise program of PD. The outcome variables were quadriceps muscle force, clinical bradykinesia measures (gait speed, timed up and go) and disease specific quality of life (Parkinson's disease questionairre-39 [PDQ-39]). Data was analyzed using separate 2 (group) x 2 (time period) ANOVAs. Results demonstrated significant time by group interaction effects for gait speed, timed up and go, and the composite PDQ-39 score (p < 0.05). Muscle force, bradykinesia, and QOL were improved to a greater degree in those that performed high intensity eccentric resistance training compared to an active control group. Additional research is needed to determine if this type of training has long-term impact and if it results in an alteration of the natural history of mobility and QOL decline in persons with PD. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Dibble, Leland E.; Marcus, Robin L.; LaStayo, Paul C.] Univ Utah, Dept Phys Therapy, Salt Lake City, UT 84108 USA. [Hale, Tessa F.] Pinnacle Performance, Salt Lake City, UT 84106 USA. [Gerber, J. Parry] Keller Army Community Hosp, West Point, NY 10996 USA. RP Dibble, LE (reprint author), Univ Utah, Dept Phys Therapy, 520 Wakara Way, Salt Lake City, UT 84108 USA. EM lee.dibble@hsc.utah.edu FU University of Utah Funding Incentive Seed Grant Program; Foundation for Physical Therapy FX Funding for this study was provided in part by the University of Utah Funding Incentive Seed Grant Program and the Foundation for Physical Therapy. NR 30 TC 78 Z9 80 U1 1 U2 27 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1353-8020 J9 PARKINSONISM RELAT D JI Parkinsonism Relat. Disord. PD DEC PY 2009 VL 15 IS 10 BP 752 EP 757 DI 10.1016/j.parkreldis.2009.04.009 PG 6 WC Clinical Neurology SC Neurosciences & Neurology GA 537RB UT WOS:000273129900005 PM 19497777 ER PT J AU Ellsworth, RE Hooke, JA Love, B Ellsworth, DL Shriver, CD AF Ellsworth, Rachel E. Hooke, Jeffrey A. Love, Brad Ellsworth, Darrell L. Shriver, Craig D. TI Molecular Changes in Primary Breast Tumors and the Nottingham Histologic Score SO PATHOLOGY & ONCOLOGY RESEARCH LA English DT Article DE Allelic imbalance; Grade; Mitosis; Nuclear atypia; Tubule formation ID PROGNOSTIC-FACTORS; GENOMIC INSTABILITY; ALLELIC IMBALANCE; CHROMOSOME 16Q; CANCER; GENE; CARCINOMAS; HETEROZYGOSITY; GRADE; ASSOCIATION AB Pathological grade is routinely used to stratify breast cancer patients into favorable and less favorable outcome groups. Mechanisms by which genomic changes in breast tumors specifically contribute to the underlying components of tumor grade - tubule formation, nuclear pleomorphism, and mitoses - are unknown. This study examined 26 chromosomal regions known to be altered in breast cancer in 256 invasive breast carcinomas. Differences in overall levels and patterns of allelic imbalance (AI) at each chromosomal region were compared for tumors with favorable (=1) and unfavorable (=3) scores for tubule formation, nuclear pleomorphism and mitotic count. Levels of AI were significantly different between samples with high and low scores for tubule formation (P < 0.001), nuclear pleomorphism (P < 0.001) and mitotic count (P < 0.05). Significantly higher levels of AI were detected at regions 11q23 and 13q12 for tumors with reduced tubule formation, chromosomes 9p21, 11q23, 13q14, 17p13 and 17q12 for those with high levels of nuclear atypia, and chromosomes 1p36, 11q23, and 13q14 for those with high mitotic counts. Region 16q11-q22 showed significantly more AI events in samples with low nuclear atypia. Patterns of genetic changes associated with poorly-differentiated breast tumors were recapitulated by the individual components of the Nottingham Histologic Score. While frequent alteration of 11q23 is common for reduced tubule formation, high nuclear atypia and high mitotic counts, suggesting that this is an early genetic change in the development of poorly-differentiated breast tumors, alterations at the other seven loci associated with poorly-differentiated tumors may specifically influence cell structure, nuclear morphology and cellular proliferation. C1 [Ellsworth, Rachel E.] Henry M Jackson Fdn Advancement Mil Med, Clin Breast Care Project, Windber, PA 15963 USA. [Hooke, Jeffrey A.; Shriver, Craig D.] Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC 20307 USA. [Love, Brad] Invitrogen, Carlsbad, CA USA. [Ellsworth, Darrell L.] Windber Res Inst, Clin Breast Care Project, Windber, PA USA. RP Ellsworth, RE (reprint author), Henry M Jackson Fdn Advancement Mil Med, Clin Breast Care Project, 620 7th St, Windber, PA 15963 USA. EM r.ellsworth@wriwindber.org FU United States Department of Defense; Henry M. Jackson Foundation for the Advancement of Military Medicine [MDAW81XWH-05-2-0075] FX This work was performed under the auspices of the Clinical Breast Care Project with funding provided by federal appropriations from the United States Department of Defense and the Henry M. Jackson Foundation for the Advancement of Military Medicine [Military Molecular Medicine Initiative MDAW81XWH-05-2-0075 to C. D. S.]. NR 39 TC 5 Z9 5 U1 0 U2 1 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1219-4956 J9 PATHOL ONCOL RES JI Pathol. Oncol. Res. PD DEC PY 2009 VL 15 IS 4 BP 541 EP 547 DI 10.1007/s12253-009-9151-3 PG 7 WC Oncology; Pathology SC Oncology; Pathology GA 539UE UT WOS:000273283100001 PM 19194786 ER PT J AU Dixon, DR Jeffrey, NR Dubey, VS Leung, KP AF Dixon, Douglas R. Jeffrey, Nicole R. Dubey, Vinod S. Leung, Kai P. TI Antimicrobial peptide inhibition of Porphyromonas gingivalis 381-induced hemagglutination is improved with a synthetic decapeptide SO PEPTIDES LA English DT Article DE Antimicrobial peptide; Porphyromonas gingivalis; Innate immunity; Oral bacteria; Hemagglutination ID HUMAN SALIVARY HISTATINS; E-SELECTIN EXPRESSION; BACTEROIDES-GINGIVALIS; INNATE IMMUNITY; ORAL CAVITY; LL-37; FAMILY; PURIFICATION; BACTERIA; DISEASE AB The effects of various antimicrobial peptides (AMPs) on disrupting the hemagglutinating ability of cellular components of the putative oral pathogen Porphyromonas gingivalis were examined. AMP inhibition of A gingivalis 381-induced hemagglutination using vesicles (VES) or outer membrane (OM) preparations was determined within standardized hemagglutination assays using various mammalian erythrocytes. A synthetic decapeptide (KSL-W) and its truncated peptide analogs were evaluated and compared with selected classes of AMPs derived from naturally occurring innate defense peptides. All tested AMPs were effective in disrupting A gingivalis-induced hemagglutination among tested erythrocytes, with the exception of magainin I and the truncated KSL-W analogs. LL-37 was generally the most potent followed by histatin 5. The synthetic decapeptide (KSL-W)was found to be similar to the histatin 8 peptide in terms of inhibitory effect. In addition, co-application assays (with selected oral-related AMPs +/- KSL-W) were employed to determine if co-application procedures would improve hemagglutination abrogation above that of oral-related AMPs alone. These experiments revealed that the KSL-W peptide improved hemagglutination inhibition above that of each of the oral-related peptides (histatin 5 and 8. LL-37) alone. Among mammalian erythrocytes, significant peptide-induced hemagglutination was observed for the cathelicidin class AMPs, LL-37 and indolicidin (>= 25 and >= 100 mu M respectively). In contrast, KSL-W did not induce erythrocyte agglutination throughout any concentration range tested (0.1-1000 mu M). Our results suggest that several AMPs are effective in disrupting A gingivalis 381-induced hemagglutination and that the co-application of a small, synthetically derived peptide may serve to augment the role of local host AMPs engaged in innate defense. Published by Elsevier Inc. C1 [Dixon, Douglas R.; Jeffrey, Nicole R.; Dubey, Vinod S.; Leung, Kai P.] US Army Dent & Trauma Res Detachment, Microbiol & Immunol Branch, Walter Reed Army Inst Res, Great Lakes Naval Training Stn, Great Lakes, IL 60088 USA. RP Dixon, DR (reprint author), US Army Dent & Trauma Res Detachment, Microbiol & Immunol Branch, Walter Reed Army Inst Res, Great Lakes Naval Training Stn, Great Lakes, IL 60088 USA. EM Douglas.Dixon@amedd.army.mil; Kai.Leung@amedd.army.mil FU US Army Medical Research and Material Command FX The authors would like to thank Mr. Sammy Wallace for his assistance in the formatting of the figures for this manuscript. We also thank the US Army staff located at the WRAIRUSADTRD, Great Lakes Naval Station, Great Lakes, IL, for their assistance during experimental procedures. This study was supported by the US Army Medical Research and Material Command for Dental Disease and Trauma Research and has been reviewed by the Walter Reed Army Institute of Research. The opinions or assertions contained herein are the private views of the author, and are not to be construed as official, or as reflecting true views of the Department of Army or the Department of Defense. NR 42 TC 5 Z9 5 U1 0 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-9781 J9 PEPTIDES JI Peptides PD DEC PY 2009 VL 30 IS 12 BP 2161 EP 2167 DI 10.1016/j.peptides.2009.07.027 PG 7 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Pharmacology & Pharmacy GA 534NH UT WOS:000272903900010 PM 19666067 ER PT J AU Marchin, RM Bhandari, RK Wall, WA Hohmann, MG Gray, JB Hoffmann, WA AF Marchin, Renee M. Bhandari, Rohit K. Wall, Wade A. Hohmann, Matthew G. Gray, Janet B. Hoffmann, William A. TI Are rare species less shade tolerant than common species in fire-prone environments? A test with seven Amorpha (Fabaceae) species SO PLANT ECOLOGY LA English DT Article DE Amorpha; Growth analysis; Shade tolerance; Conservation biology; Rare species ID PINE-WIREGRASS ECOSYSTEM; TROPICAL RAIN-FOREST; SEED SIZE; PLANT-DISTRIBUTIONS; TALLGRASS PRAIRIE; LIGHT GRADIENT; WOODY-PLANTS; NEW-ZEALAND; TREE; GROWTH AB Increases in tree density resulting from fire suppression have contributed considerably to the loss of savanna and grassland habitats in North America. Inability to tolerate shade is likely an important cause of species loss in areas that have not maintained historical burning regimes. We conducted an experiment to test whether differences in shade tolerance can explain rarity within the genus Amorpha. Four common and three rare species of Amorpha were grown in a greenhouse for 100 days in direct sun or under 90% shade. Overall, shading significantly reduced growth and survival and affected allocation among species, but these differences did not differ consistently between common and rare species. Ability to tolerate shade was best explained by phenotypic plasticity, with greater shade survival being exhibited by species with the largest changes in leaf area ratio. Furthermore, this study demonstrated that all three of the rare species can be readily cultivated under greenhouse conditions. C1 [Marchin, Renee M.; Bhandari, Rohit K.; Wall, Wade A.; Hoffmann, William A.] N Carolina State Univ, Dept Plant Pathol, Raleigh, NC 27695 USA. [Hohmann, Matthew G.] USA, Engineer Res & Dev Ctr, Champaign, IL 61822 USA. [Gray, Janet B.] Ft Bragg Garrison Command Abn, Endangered Species Branch, Directorate Publ Works, Dept Army, Ft Bragg, NC 28310 USA. RP Hoffmann, WA (reprint author), N Carolina State Univ, Dept Plant Pathol, Campus Box 7612, Raleigh, NC 27695 USA. EM wahoffma@ncsu.edu RI Hoffmann, William/E-8894-2010; OI Hoffmann, William/0000-0002-1926-823X; Marchin, Renee/0000-0002-4154-8924 FU US Army Engineer Research and Development Center; Construction Engineering Research Laboratory under Agreement [W9132T-07-2-0019] FX We thank Candace Knotts for help with data collection, the staff of the NCSU Phytotron for providing the growth chamber and greenhouse facilities, and two anonymous reviewers for helpful comments. This research was funded by the Department of Defense, US Army Engineer Research and Development Center, Construction Engineering Research Laboratory under Agreement # W9132T-07-2-0019. NR 72 TC 4 Z9 4 U1 1 U2 24 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1385-0237 J9 PLANT ECOL JI Plant Ecol. PD DEC PY 2009 VL 205 IS 2 BP 249 EP 260 DI 10.1007/s11258-009-9614-3 PG 12 WC Plant Sciences; Ecology; Forestry SC Plant Sciences; Environmental Sciences & Ecology; Forestry GA 510KR UT WOS:000271087900008 ER PT J AU Salinas, NL Jackson, O Dunham, B Bartlett, SP AF Salinas, Nathan L. Jackson, Oksana Dunham, Brian Bartlett, Scott P. TI Anatomical Dissection and Modified Sihler Stain of the Lower Branches of the Facial Nerve SO PLASTIC AND RECONSTRUCTIVE SURGERY LA English DT Article ID MARGINAL MANDIBULAR BRANCH; SURGICAL ANATOMY; TREATMENT OPTIONS; PSEUDO-PARALYSIS; CERVICAL BRANCH; FACE-LIFT; PLATYSMA; MUSCLE AB Background: The cervical branch of the facial nerve and the muscles it supplies play a role in perioral function and neck aesthetics. Paralysis of the cervical branch in some patients may result in lip depressor deficiency and an asymmetric smile. It is unclear whether this is the result of platysmal weakness alone, or attributable to coinnervation of the lip depressor muscles by the cervical and marginal mandibular branches of the facial nerve. The purpose of this study was to provide a detailed description of the anatomy and function of the cervical branch to assist surgeons operating in the face and neck. Methods: Anatomical dissection of the marginal mandibular and cervical branches was performed in 20 hemifacial human cadaver specimens. The modified Sihler stain was used to stain the extramuscular and intramuscular nerve branches in eight specimens. The course, branching patterns, and neuromuscular relationships of the cervical and marginal mandibular branches were examined. Results: Multiple cervical branches were identified in 85 percent of specimens, and an anastomosis with the transverse cervical cutaneous nerve was documented consistently. A communication between the marginal mandibular and cervical branches was identified in seven specimens, and coinnervation of the depressor anguli oris by intramuscular cervical branch ramifications was seen in one. Conclusions: A detailed description of the anatomy of the cervical branch is provided. Coinnervation of the lower lip depressors by the cervical branch remains a plausible explanation for the lower lip deformity attributed to cervical branch paralysis in some patients. (Plast. Reconstr. Surg. 124: 1905, 2009.) C1 [Bartlett, Scott P.] Childrens Hosp Philadelphia, Div Plast & Reconstruct Surg, Philadelphia, PA 19104 USA. Childrens Hosp Philadelphia, Div Otolaryngol, Philadelphia, PA 19104 USA. Brooke Army Med Ctr, Dept Otolaryngol, Ft Sam Houston, TX 78234 USA. RP Bartlett, SP (reprint author), Childrens Hosp Philadelphia, Div Plast & Reconstruct Surg, 1st Floor Wood Ctr,34th & Civ Ctr Blvd, Philadelphia, PA 19104 USA. EM scott.bartlett@uphs.upenn.edu NR 29 TC 6 Z9 6 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0032-1052 J9 PLAST RECONSTR SURG JI Plast. Reconstr. Surg. PD DEC PY 2009 VL 124 IS 6 BP 1905 EP 1915 DI 10.1097/PRS.0b013e3181bceea5 PG 11 WC Surgery SC Surgery GA 530TQ UT WOS:000272615600020 PM 19952646 ER PT J AU Ku, BC Kim, DK Lee, JS Blumstein, A Kumar, J Samuelson, LA AF Ku, Bon-Cheol Kim, Dae Kyom Lee, Jun Seok Blumstein, Alexandre Kumar, Jayant Samuelson, Lynne A. TI Synthesis and Properties of Water Soluble Single-Walled Carbon Nanotube Graft Ionic Polyacetylene Nanocomposites SO POLYMER COMPOSITES LA English DT Article ID TRANSFER RADICAL POLYMERIZATION; CONJUGATED POLYMERS; MULTILAYER FILMS; OPTICAL-PROPERTIES; POLYANILINE; FUNCTIONALIZATION; COMPOSITE; SURFACE; TRIFLUOROMETHANESULFONATE; POLYPYRROLE AB Water-soluble single-walled carbon nanotube-polyacetylene [SWNT-PA, SWNT-P(2EPy-MeTf)] nanocomposites have been synthesized by using the surface initiated "grafting-from" method. The FT-IR spectra confirmed the formation of an amide bond between the functionalized SWNTs and the initiator, 4-(2-Aminoethyl) pyridine, to polymerize N-Methyl-2-ethynlypyridinium triflate (2EPy-MeTf). UV-vis spectroscopy indicated that the degree of polymerization of P(2EPy-MeTf) in the SWNT-polyacetylene composites is 15, based on the Lewis-Calvin equation. The SWNT-polyacetylene composites have been characterized by TGA, AFM, and TEM. From TGA analysis, the loading of SWNTs in the SWNT grafted ionic polyacetylenes is estimated to be 22%. AFM and TEM images clearly showed that the nanotube is wrapped with the PA. The SWNT-polyacetylene composites displayed high water solubility (8 mg/ml). The room temperature electrical conductivity of the doped SWNT-polyacetylene composites was found to be in the range of 10(-3) to 10(-4) S/cm, an order of magnitude of increase over neat P(2EPy-MeTf) and a two order of magnitude increase over Dendrimer-polyacetylen composites. POLYM. COMPOS., 30:1817-1824, 2009. (C) 2008 Society of Plastics Engineers C1 [Kumar, Jayant] Univ Massachusetts, Dept Phys, Lowell, MA 01854 USA. [Ku, Bon-Cheol; Kim, Dae Kyom; Lee, Jun Seok; Blumstein, Alexandre] Univ Massachusetts, Dept Chem, Ctr Adv Mat, Polymer Sci Program, Lowell, MA 01854 USA. [Samuelson, Lynne A.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Kumar, J (reprint author), Univ Massachusetts, Dept Phys, Lowell, MA 01854 USA. EM jayant_kumar@uml.edu FU US Army Natick Soldier Research, Development and Engineering Center [DAAD-16-01-C-004]; Graduate Student Association (PDA and GRGA) of UMass Lowell FX Contract grant sponsor: US Army Natick Soldier Research, Development and Engineering Center; contract grant number: DAAD-16-01-C-004; Contract grant sponsor: Graduate Student Association (PDA and GRGA) of UMass Lowell. NR 71 TC 4 Z9 4 U1 0 U2 9 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0272-8397 J9 POLYM COMPOSITE JI Polym. Compos. PD DEC PY 2009 VL 30 IS 12 BP 1817 EP 1824 DI 10.1002/pc.20754 PG 8 WC Materials Science, Composites; Polymer Science SC Materials Science; Polymer Science GA 526JR UT WOS:000272284900011 ER PT J AU Campanella, A La Scala, JJ Wool, RP AF Campanella, Alejandrina La Scala, John J. Wool, Richard P. TI The Use of Acrylated Fatty Acid Methyl Esters as Styrene Replacements in Triglyceride-based Thermosetting Polymers SO POLYMER ENGINEERING AND SCIENCE LA English DT Article ID MAGNETIC-RESONANCE-SPECTROSCOPY; RENEWABLE RAW-MATERIALS; SOYBEAN OIL; YIELD DETERMINATION; POLYURETHANE FOAMS; FIBER COMPOSITES; VEGETABLE-OILS; POLYOLS; LIGNIN; H-1-NMR AB Resins containing plant oil-based cross-linkers were studied with two reactive diluents: a styrene and an acrylated fatty acid methyl ester-based (AFAME) monomer. Acrylated epoxidized soybean oil and maleinated castor oil monoglyceride were bio-based cross-linkers used. The viscosity and mechanical properties of the resulting polymers were measured and analyzed. Both bio-based cross-linkers prepared using the modified AFAME as diluent had a fairly high viscosity, so blends of AFAME and styrene were needed to meet the viscosity requirements established by the composite industry (<1000 cP at room temperature). In addition, the glass transition temperature (T-g) and stiffness of bio-based cross-linker/AFAME polymers were significantly lower than the resin/styrene polymers. Ternary blends of maleinated castor oil monoglyceride with AFAME and styrene improved the mechanical properties to acceptable comparable values (storage modulus at 30 degrees C similar to 1200 MPa and T-g similar to 100 degrees C). The addition of 5 wt% of chemically modified lignin led to an improvement in the mechanical properties of the polymeric matrix but caused an increase in the viscosity. POLYM. ENG. SCI., 49:2384-2392, 2009. (C) 2009 Society of Plastics Engineers C1 [Campanella, Alejandrina; Wool, Richard P.] Univ Delaware, Dept Chem Engn, Newark, DE 19716 USA. [Campanella, Alejandrina; Wool, Richard P.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. [La Scala, John J.] USA, Res Lab, AMSRD WM MC, Aberdeen Proving Ground, MD 21005 USA. RP Wool, RP (reprint author), Univ Delaware, Dept Chem Engn, Newark, DE 19716 USA. EM wool@udel.edu FU Army Research Lab through the Army Materials Center of Excellence in Composite Materials at the University of Delaware FX The authors thank Army Research Lab for financial support of this research through the Army Materials Center of Excellence in Composite Materials at the University of Delaware. They also thank the Wagner Research Group at the University of Delaware, Department of Chemical Engineering for the use of their Rheometer. NR 58 TC 24 Z9 24 U1 3 U2 31 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0032-3888 EI 1548-2634 J9 POLYM ENG SCI JI Polym. Eng. Sci. PD DEC PY 2009 VL 49 IS 12 BP 2384 EP 2392 DI 10.1002/pen.21486 PG 9 WC Engineering, Chemical; Polymer Science SC Engineering; Polymer Science GA 524DU UT WOS:000272124800010 ER PT J AU Shackman, AJ McMenamin, BW Maxwell, JS Greischar, LL Davidson, RJ AF Shackman, Alexander J. McMenamin, Brenton W. Maxwell, Jeffrey S. Greischar, Lawrence L. Davidson, Richard J. TI Right Dorsolateral Prefrontal Cortical Activity and Behavioral Inhibition SO PSYCHOLOGICAL SCIENCE LA English DT Article ID FRONTAL EEG ASYMMETRY; INDIVIDUAL-DIFFERENCES; ACTIVATION SYSTEMS; EMOTION REGULATION; ANXIETY; FEAR; RESPONSES; RISK; PERSONALITY; PREDICTION AB Individuals show marked variation in their responses to threat. Such individual differences in behavioral inhibition play a profound role in mental and physical well-being. Behavioral inhibition is thought to reflect variation in the sensitivity of a distributed neural system responsible for generating anxiety and organizing defensive responses to threat and punishment. Although progress has been made in identifying the key constituents of this behavioral inhibition system in humans, the involvement of dorsolateral prefrontal cortex (DLPFC) remains unclear. Here, we acquired self-reported Behavioral Inhibition System Sensitivity scores and high-resolution electroencephalography from a large sample (n = 51). Using the enhanced spatial resolution afforded by source modeling techniques, we show that individuals with greater tonic (resting) activity in right-posterior DLPFC rate themselves as more behaviorally inhibited. This observation provides novel support for recent conceptualizations of behavioral inhibition and clues to the mechanisms that might underlie variation in threat-induced negative affect. C1 [Shackman, Alexander J.; Maxwell, Jeffrey S.; Greischar, Lawrence L.; Davidson, Richard J.] Univ Wisconsin, Lab Affect Neurosci, Madison, WI 53706 USA. [Shackman, Alexander J.; Greischar, Lawrence L.; Davidson, Richard J.] Univ Wisconsin, Waisman Lab Brain Imaging & Behav, Madison, WI 53706 USA. [McMenamin, Brenton W.] Univ Minnesota Twin Cities, Ctr Cognit Sci, Minneapolis, MN USA. [Maxwell, Jeffrey S.] USA, Res Lab, Aberdeen, MD USA. RP Shackman, AJ (reprint author), Univ Wisconsin, Lab Affect Neurosci, 1202 W Johnson St, Madison, WI 53706 USA. EM shackman@wisc.edu; rjdavids@wisc.edu RI Shackman, Alexander/B-3458-2009 FU NICHD NIH HHS [32-HD007151, T32 HD007151, T32 HD007151-30]; NIMH NIH HHS [P50 MH069315, P50 MH069315-02, P50 MH069315-03, P50 MH069315-04, P50 MH069315-05, P50-MH069315, R01 MH043454, R01 MH043454-18, R01 MH043454-19, R01 MH043454-20, R37 MH043454, R37 MH043454-15, R37 MH043454-16, R37 MH043454-17, R37/R01-MH43454] NR 33 TC 83 Z9 84 U1 6 U2 23 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0956-7976 J9 PSYCHOL SCI JI Psychol. Sci. PD DEC PY 2009 VL 20 IS 12 BP 1500 EP 1506 PG 7 WC Psychology, Multidisciplinary SC Psychology GA 524SQ UT WOS:000272163600012 PM 19906125 ER PT J AU Cordes, JA Thomas, J Wong, RS Carlucci, D AF Cordes, J. A. Thomas, J. Wong, R. S. Carlucci, D. TI Reliability estimates for flawed mortar projectile bodies SO RELIABILITY ENGINEERING & SYSTEM SAFETY LA English DT Article DE Reliability; Safety; Defects; Limit state function; Distributions; Failure; Mortars; Margin; Manufacturing defect; Strength; Safety-critical; X-rays; Finite element analysis; Case study; Monte Carlo simulation AB The Army routinely screens mortar projectiles for defects in safety-critical parts. In 2003, several lots of mortar projectiles had a relatively high defect rate, 0.24%. Before releasing the projectiles, the Army reevaluated the chance of a safety-critical failure. Limit state functions and Monte Carlo simulations were used to estimate reliability. Measured distributions of wall thickness, defect rate, material strength, and applied loads were used with calculated stresses to estimate the probability of failure. The results predicted less than one failure in one million firings. As of 2008, the mortar projectiles have been used without any safety-critical incident. Published by Elsevier Ltd. C1 [Cordes, J. A.; Thomas, J.; Wong, R. S.; Carlucci, D.] US Army, ARDEC, Fuze & Precis Armaments Technol Directorate, AMSRD AAR MEF E,Anal & Evaluat Div, Picatinny Arsenal, NJ 07806 USA. RP Cordes, JA (reprint author), US Army, ARDEC, Fuze & Precis Armaments Technol Directorate, AMSRD AAR MEF E,Anal & Evaluat Div, Picatinny Arsenal, NJ 07806 USA. EM jennifer.cordes@us.army.mil NR 17 TC 1 Z9 1 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0951-8320 J9 RELIAB ENG SYST SAFE JI Reliab. Eng. Syst. Saf. PD DEC PY 2009 VL 94 IS 12 BP 1887 EP 1893 DI 10.1016/j.ress.2009.06.004 PG 7 WC Engineering, Industrial; Operations Research & Management Science SC Engineering; Operations Research & Management Science GA 496RN UT WOS:000269993600002 ER PT J AU Summers, RL Ward, KR Witten, T Convertino, VA Ryan, KL Coleman, TG Hester, RL AF Summers, Richard L. Ward, Kevin R. Witten, Tarynn Convertino, Victor A. Ryan, Kathy L. Coleman, Thomas G. Hester, Robert L. TI Validation of a computational platform for the analysis of the physiologic mechanisms of a human experimental model of hemorrhage SO RESUSCITATION LA English DT Article DE Systems analysis; Validation; Hemorrhagic shock ID COMPUTER-CONTROLLED INFUSION; BODY NEGATIVE-PRESSURE; PREDICTIVE PERFORMANCE; IMPEDANCE CARDIOGRAPHY; CARDIAC-OUTPUT; STROKE VOLUME; HYPERTENSION; PROPOFOL; SYSTEMS; FINGER AB Computational models of integrative physiology may serve as a framework for understanding the complex adaptive responses essential for homeostasis in critical illness and resuscitation and may provide insights for design of diagnostics and therapeutics. In this Study a Computer model of human physiology was compared to results obtained from experiments using Lower Body Negative Pressure (LBNP) analog model of human hemorrhage. LBNP has been demonstrated to produce physiologic changes in humans consistent with hemorrhage. The computer model contains over 4000 parameters that describe the detailed integration of physiology based upon basic physical principles and established biologic interactions. The LBNP protocol consisted of a 5 min rest period (0 mmHg) followed by 5 min of chamber decompression of the lower body to -15. -30, -45, and -60 mmHg and additional increments of -10 mmHg every 5 Mill until the onset of hemodynamic decompensation (n = 20). Physiologic parameters recorded include mean arterial pressure (MAP), cardiac output (CO), and venous oxygen saturation (SVO(2); from peripheral venous blood), during the last 30 s at each LBNP level. The Computer model analytic procedure recreates the investigational protocol for a virtual individual in an In Silico environment. After baseline normalization, the model predicted measurements for MAP, CO, and SVO(2) were compared to those observed through the entire range of LBNP. Differences were evaluated using standard statistical performance error measurements (median performance error (PE) <5%). The simulation results closely tracked the average changes observed during LBNP. The predicted MAP fell outside the standard error measurement for the experimental data at only LBNP -30 mmHg while CO was more variable. The predicted SVO2 fell outside the standard error measurement for the experimental data only during the post-LBNP recovery point. However, the statistical median PE measurement was found to be within the 5% objective error Measure (1.3% for MAP, -3.5% for CO, and 3.95% for SVO(2)). The computer model was found to accurately predict the experimental results observed using LBNP. The model Should be explored as a platform for studying concepts and physiologic mechanisms of hemorrhage including its diagnosis and treatment. (C) 2009 Elsevier Ireland Ltd. All rights reserved. C1 [Summers, Richard L.] Univ Mississippi, Med Ctr, Dept Emergency Med, Jackson, MS 39216 USA. [Ward, Kevin R.; Witten, Tarynn] Virginia Commonwealth Univ, Reanimat Engn Shock Ctr, Richmond, VA USA. [Witten, Tarynn] Virginia Commonwealth Univ, Ctr Study Biol Complex, Richmond, VA USA. [Convertino, Victor A.; Ryan, Kathy L.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Summers, RL (reprint author), Univ Mississippi, Med Ctr, Dept Emergency Med, 2500 N State St, Jackson, MS 39216 USA. EM rsummers@pol.net OI Hester, Robert/0000-0003-0227-557X FU NHLBI NIH HHS [P01 HL051971-14, HL-51971, P01 HL051971] NR 35 TC 26 Z9 26 U1 0 U2 5 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0300-9572 J9 RESUSCITATION JI Resuscitation PD DEC PY 2009 VL 80 IS 12 BP 1405 EP 1410 DI 10.1016/j.resuscitation.2009.09.001 PG 6 WC Critical Care Medicine; Emergency Medicine SC General & Internal Medicine; Emergency Medicine GA 543KH UT WOS:000273575400016 PM 19804937 ER PT J AU Brinsfield, JW AF Brinsfield, John W. TI THE US MILITARY CHAPLAINCY, THEN AND NOW SO REVIEW OF FAITH & INTERNATIONAL AFFAIRS LA English DT Article AB U.S. military chaplains and chaplain assistants have engaged persons of diverse faith groups in various ways during the course of American history. In the early period, Christian clergy and missionaries were primarily interested in converting people of other faiths to Christianity. However, as the United States and its military became more pluralistic and more engaged in conflicts around the world, a broader mission to win the hearts and minds of the people in the area of operations became more urgent. C1 USA, Chaplain Ctr & Sch, Washington, DC 20310 USA. RP Brinsfield, JW (reprint author), USA, Chaplain Ctr & Sch, Washington, DC 20310 USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU COUNCIL FAITH & INT AFFAIRS PI ARLINGTON PA PO BOX 12205, ARLINGTON, VA 22219-2205 USA SN 1557-0274 J9 REV FAITH INT AFF JI Rev. Faith Int. Aff. PD WIN PY 2009 VL 7 IS 4 BP 17 EP 24 PG 8 WC Religion SC Religion GA 542EL UT WOS:000273475000003 ER PT J AU Batchinsky, AI Salinas, J Kuusela, T Necsoiu, C Jones, J Cancio, LC AF Batchinsky, Andriy I. Salinas, Jose Kuusela, Tom Necsoiu, Corina Jones, John Cancio, Leopoldo C. TI RAPID PREDICTION OF TRAUMA PATIENT SURVIVAL BY ANALYSIS OF HEART RATE COMPLEXITY: IMPACT OF REDUCING DATA SET SIZE SO SHOCK LA English DT Article DE Wounds and injuries; transportation of patients; electrocardiography; complexity; nonlinear analysis; spectrum analysis ID RATE DYNAMICS; LIFESAVING INTERVENTIONS; NONLINEAR DYNAMICS; RATE-VARIABILITY; FIBRILLATION; PHYSIOLOGY; MORTALITY; FRACTALS; CHAOS AB Heart rate complexity (HRC) is an emerging "new vital sign" for critically ill and injured patients. Traditionally, 800-beat data sets have been used to calculate HRC variables, thus limiting their practical use in an emergency. We sought to investigate whether data set reductions diminish the use of HRC to predict mortality in prehospital trauma patients. Ectopy-free, 800-beat sections of electrocardiogram (EKG) were collected from 31 prehospital trauma patients during their helicopter transport to a level 1 trauma center. Twenty patients survived (survivors) and 11 died (nonsurvivors) after admission. HRC was assessed via approximate entropy (ApEn), sample entropy (SampEn), and similarity of distributions (SOD). The amplitude of high-frequency oscillations was measured via the method of complex demodulation. This analysis was repeated in data sets of 800, 600, 400, 200, and 100 beats. For 800 beats, ApEn and SampEn were lower in nonsurvivors than in survivors, and SOD was higher. With data set reduction, ApEn in survivors and nonsurvivors gradually approached each other but remained different until the 200-beat dataset. Sample entropy did not change with data shortening and remained lower in nonsurvivors in all data sets. Similarity of distributions was nearly constant within groups for all data sets and discriminated survivors from nonsurvivors in 800- and 100-beat data sets. High-frequency amplitude distinguished survivors from nonsurvivors in 400-, 200-, and 100-beat data sets. Logistic regression was performed for the 800-, 200-, and 100-beat data sets, retaining SampEn as a predictor of mortality (area under the receiver-operating-characteristic curves, 0.821-0.895). HRC decreased in nonsurvivors versus survivors. This finding was confirmed for data sets as short as 100 beats by computationally different metrics. SampEn, SOD, and complex demodulation were relatively unaffected by data set reduction. These metrics may be useful for rapid identification of trauma patients with potentially lethal injuries using short EKG data sets. C1 [Batchinsky, Andriy I.; Salinas, Jose; Necsoiu, Corina; Jones, John; Cancio, Leopoldo C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Kuusela, Tom] Univ Turku, Dept Phys, SF-20500 Turku, Finland. RP Batchinsky, AI (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM andriy.batchinsky@amedd.army.mil FU Combat Casualty Care Research Program; Telemedicine and Advanced Technology Research Center; US Army Medical Research and Materiel Command FX This study was supported by the Combat Casualty Care Research Program and the Telemedicine and Advanced Technology Research Center, US Army Medical Research and Materiel Command. NR 26 TC 30 Z9 30 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD DEC PY 2009 VL 32 IS 6 BP 565 EP 571 DI 10.1097/SHK.0b013e3181a993dc PG 7 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 523GX UT WOS:000272061600001 PM 19487984 ER PT J AU Walde, AD Walde, AM Delaney, DK Fater, LL AF Walde, Andrew D. Walde, Angela M. Delaney, David K. Fater, Larry L. TI BURROWS OF DESERT TORTOISES (GOPHERUS AGASSIZII) AS THERMAL REFUGIA FOR HORNED LARKS (EREMOPHILA ALPESTRIS) IN THE MOJAVE DESERT SO SOUTHWESTERN NATURALIST LA English DT Article ID CALIFORNIA; SELECTION; NEVADA AB The Mojave Desert is one of the driest, and honest deserts in North America. One would expect that birds living in this desert would be specialists adapted to survive such an environment. However, most of the avifauna present in the Mojave Desert range into cooler, more-humid regions. We report observations of horned larks (Eremophila alpestris) using burrows of the desert tortoise (Gopherus agassizii) during summer as refugia from hot above-ground temperatures. We show that horned larks appear Selective of the micro-environment they choose and that burrows are the coolest, most-humid, microsites available. By using burrows of desert tortoises, horned larks may reduce evaporative water loss by <= 65% and they may avoid physiological stress, or potentially death. Additional research should investigate the importance of burrows of desert tortoises to other species as it is likely to provide a key microhabitat to many species that reside in the Mojave Desert. C1 [Walde, Andrew D.] ITS Corp, Alascadero, CA 93422 USA. [Walde, Angela M.] Walde Res & Environm Consulting, Victorville, CA 92392 USA. [Delaney, David K.; Fater, Larry L.] USA, Construct Engn Res Lab, Champaign, IL 61826 USA. RP Walde, AD (reprint author), ITS Corp, 8000 San Gregorio Rd, Alascadero, CA 93422 USA. EM awalde@hotmail.com FU United States Army Construction Engineering Research Laboratory; Department of Public Works Environmental at the National Training Center, Fort Irwin, California FX We acknowledge the United States Army Construction Engineering Research Laboratory for initiating and funding the project. M. Quillman from Department of Public Works Environmental at the National Training Center, Fort Irwin, California, contributed logistical support and funding. In addition, this project could not have been completed without the numerous field hours contributed by Our dedicated Staff. Research oil the desert tortoise was conducted under recovery permit TE066452-1 issued by the United States Fish and Wildlife Service and Memorandum of Understanding for Scientific Collecting Permit 802005-03 issued by California Department of Fish and Game. NR 29 TC 5 Z9 5 U1 0 U2 8 PU SOUTHWESTERN ASSOC NATURALISTS PI SAN MARCOS PA SOUTHWEST TEXAS STATE UNIV, DEPT BIOLOGY, 601 UNIVERSITY DR, SAN MARCOS, TX 78666 USA SN 0038-4909 J9 SOUTHWEST NAT JI Southw. Natural. PD DEC PY 2009 VL 54 IS 4 BP 375 EP 381 DI 10.1894/MH-41.1 PG 7 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 535RX UT WOS:000272989500001 ER PT J AU Cleland, JA Fritz, JM Kulig, K Davenport, TE Eberhart, S Magel, J Childs, JD AF Cleland, Joshua A. Fritz, Julie M. Kulig, Kornelia Davenport, Todd E. Eberhart, Sarah Magel, Jake Childs, John D. TI Comparison of the Effectiveness of Three Manual Physical Therapy Techniques in a Subgroup of Patients With Low Back Pain Who Satisfy a Clinical Prediction Rule A Randomized Clinical Trial SO SPINE LA English DT Article DE clinical prediction rule; low back pain; thrust manipulation ID SPINAL MANIPULATIVE THERAPY; FEAR-AVOIDANCE BELIEFS; PRIMARY-CARE; MANAGEMENT PROGRAM; UNITED-STATES; LUMBAR; PHYSIOTHERAPY; DISABILITY; EXERCISE; QUESTIONNAIRE AB Study Design. Randomized clinical trial. Objective. The purpose of this randomized clinical trial was to examine the generalizability of 3 different manual therapy techniques in a patient population with low back pain that satisfy a clinical prediction rule (CPR). Summary of Background Data. Recently a CPR that identifies patients with LBP who are likely to respond rapidly and dramatically to thrust manipulation has been developed and validated. The generalizability of the CPR requires further investigation. Methods. A total of 112 patients were enrolled in the trial and provided demographic information and completed a number of self-report questionnaires including the Oswestry Disability Questionnaire (ODQ) and the Numerical Pain Rating Scale (NPRS) at baseline, 1-week, 4-weeks, and 6-months. Patients were randomly assigned to receive 1 of the 3 manual therapy techniques for 2 consecutive treatment sessions followed by exercise regimen for an additional 3 sessions. We examined the primary aim using a linear mixed model for repeated measures, using the ODQ and NPRS as dependent variables. The hypothesis of interest was the group by time interaction, which was further explored with pair-wise comparisons of the estimated marginal means. Results. There was a significant group x time interaction for the ODQ ( P < 0.001) and NPRS scores ( P = 0.001). Pair-wise comparisons revealed no differences between the supine thrust manipulation and side-lying thrust manipulation at any follow-up period. Significant differences in the ODQ and NPRS existed at each follow-up between the thrust manipulation and the nonthrust manipulation groups at 1-week and 4-weeks. There was also a significant difference in ODQ scores at 6-months in favor of the thrust groups. Conclusion. The results of the study support the generalizability of the CPR to another thrust manipulation technique, but not to the nonthrust manipulation technique that was used in this study. In general, our results also provided support that the CPR can be generalized to different settings from which it was derived and validated. However, additional research is needed to examine this issue. C1 [Cleland, Joshua A.] Franklin Pierce Univ, Dept Phys Therapy, Concord, NH 03301 USA. [Cleland, Joshua A.; Eberhart, Sarah] Concord Hosp, Rehabil Serv, Concord, NH USA. [Fritz, Julie M.] Univ Utah, Div Phys Therapy, Salt Lake City, UT USA. [Fritz, Julie M.] Intermt Healthcare, Salt Lake City, UT USA. [Kulig, Kornelia] Univ So Calif, Sch Dent, Div Biokinesiol & Phys Therapy, Musculoskeletal Biomech Res Lab, Los Angeles, CA 90089 USA. [Kulig, Kornelia] Univ So Calif, Keck Sch Med, Dept Orthopaed Surg, Los Angeles, CA 90033 USA. [Davenport, Todd E.] Univ Pacific, Thomas J Long Sch Pharm & Hlth Sci, Dept Phys Therapy, Stockton, CA 95211 USA. [Magel, Jake] Orthoped Specialty Hosp, Salt Lake City, UT USA. [Childs, John D.] Baylor Univ, USA, Doctoral Program Phys Therapy, San Antonio, TX USA. RP Cleland, JA (reprint author), Franklin Pierce Univ, Dept Phys Therapy, 5 Chenell Dr, Concord, NH 03301 USA. EM joshcleland@comcast.net RI Kulig, Kornelia/E-4931-2010 FU American Academy of Orthopedic Manual Physical Therapists, 2005 Cardon Rehabilitation Products Grant FX The authors thank American Academy of Orthopedic Manual Physical Therapists, 2005 Cardon Rehabilitation Products Grant for providing funding for this project. These organizations played no role in the design, conduct, or reporting of the study or in the decision to submit the manuscript for publication. The authors also thank all the therapists who participated in data collection, George Beneck, Tracy Carter, Sheryl Cheney, Jacquelyn Dylla, Mildred Limcay, Robert Landel, Leslie Mabey, Scott Mcgaw, Steven Moffit, Guy Majkowski, Jessica Palmer, Jonathan Sum, Aaron Swalberg, Eric Passey, Kimiko Yamada. NR 58 TC 62 Z9 64 U1 0 U2 11 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD DEC 1 PY 2009 VL 34 IS 25 BP 2720 EP 2729 DI 10.1097/BRS.0b013e3181b48809 PG 10 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 527EI UT WOS:000272349200002 PM 19940729 ER PT J AU Belard, A Tinnel, B Wilson, S Ferro, R O'Connell, J AF Belard, Arnaud Tinnel, Brent Wilson, Steve Ferro, Ralph O'Connell, John TI Development of a Remote Proton Radiation Therapy Solution over Internet2 SO TELEMEDICINE JOURNAL AND E-HEALTH LA English DT Article DE business administration/economics; distance learning; remote treatment planning ID PROSTATE-CANCER; TELEMEDICINE; CARE; RADIOTHERAPY; SYSTEM; COLLABORATION; TELERADIOLOGY; IRRADIATION; IMPACT; VOLUME AB Through our existing partnership, our research program has leveraged the benefits of proton radiation therapy through the development a robust telemedicine solution for remote proton therapy planning. Our proof-of-concept system provides a cost-effective and functional videoconferencing desktop platform for both ad-hoc and scheduled communication, as well as a robust interface for data collaboration (application-sharing of a commercial radiation treatment planning package). Over a 2-year period, our evaluation of this model has highlighted the inherent benefits of this affordable remote treatment planning solution, i.e., (1) giving physicians the ability to remotely participate in refining and generating proton therapy plans via a secure and robust Internet2 VPN tunnel to the University of Pennsylvania's commercial proton treatment planning package; (2) allowing cancer-care providers sending patients to a proton treatment facility to participate in treatment planning decisions by enabling referring or accepting providers to initiate ad-hoc, point-to-point communication with their counterparts to clarify and resolve issues arising before or during patient treatment; and thus (3) allowing stewards of an otherwise highly centralized resource the ability to encourage wider participation with and referrals to sparsely located proton treatment centers by adapting telemedicine techniques that allow sharing of proton therapy planning services. We believe that our elegant and very affordable approach to remote proton treatment planning opens the door to greater worldwide referrals to the scarce resource of proton treatment units and wide-ranging scientific collaboration, both nationally and internationally. C1 [Belard, Arnaud] Walter Reed Army Med Ctr, Henry M Jackson Fdn Advancement Mil Med, Washington, DC 20307 USA. [Belard, Arnaud; Tinnel, Brent; O'Connell, John] Walter Reed Army Med Ctr, Dept Radiol, Radiat Oncol Serv, Washington, DC 20307 USA. [Wilson, Steve] Univ Pittsburgh, Med Ctr, Dept Radiat Oncol, Pittsburgh, PA USA. [Ferro, Ralph] Univ Penn, Dept Radiat Oncol, Philadelphia, PA 19104 USA. RP Belard, A (reprint author), Walter Reed Army Med Ctr, Henry M Jackson Fdn Advancement Mil Med, 6900 Georgia Ave NW,Bldg 2,Room 1H46A, Washington, DC 20307 USA. EM arnaud.belard@amedd.army.mil FU U.S. Army Medical Research and Materiel Command (USAMRMC) [DAMD17-W81XWH-04-2-0022] FX Our research program would like to further recognize the contributions of the following individuals for their efforts: Brian Robinson, Steve Gilmer, Paul Gates, Mike Valentine, and Raymond Reid (WRAMC-Directorate of Information Management). Additionally, we would like to thank Colonel Michael Brazaitis, M.D., Chairman of the Department of Radiology at WRAMC, for the resources provided to further this work. NR 32 TC 1 Z9 1 U1 0 U2 2 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-5627 J9 TELEMED J E-HEALTH JI Telemed. J. e-Health PD DEC PY 2009 VL 15 IS 10 BP 998 EP 1004 DI 10.1089/tmj.2009.0065 PG 7 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 535TU UT WOS:000272995000049 PM 19929221 ER PT J AU Thomas, JE Munir, JA McIntyre, PZ Ferguson, MA AF Thomas, John E. Munir, Jamalah A. McIntyre, Peter Z. Ferguson, Michael A. TI STEMI in a 24-Year-Old Man after Use of a Synephrine-Containing Dietary Supplement A Case Report and Review of the Literature SO TEXAS HEART INSTITUTE JOURNAL LA English DT Review DE Citrus/adverse effects; coronary vasospasm/complications/etiology; dietary supplements/adverse effects/poisoning; myocardial infarction/chemically induced; plant preparations; synephrine; weight loss/drug effects; United States Food and Drug Administration ID MYOCARDIAL-INFARCTION AB Billions of dollars are spent annually in the United States in the largely unregulated market of dietary supplements. Many of these supplements are marketed as weight-loss and athletic-performance-enhancement products. The association of various ephedra-containing products with adverse cardiovascular events has led to a ban on the sale of these products by the U. S. Food and Drug Administration. The result has been the emergence of new formulations marketed for weight loss and athletic-performance enhancement that are "ephedra-free" but contain other sympathomimetic substances, the safety of which has not been established. We present the case of a previously healthy 24-year-old man who presented with an ST-segment-elevation myocardial infarction (STEMI) within hours of taking the ephedra-free product Nutrex Lipo-6x (R). Emergent coronary angiography revealed the presence of extensive, diffuse thrombus in the left anterior descending coronary artery. The patient had no risk factors for coronary artery disease or myocardial infarction; this includes the absence of a hypercoagulable state and the absence of a history of illicit drug use. This case of STEMI-associated as it is with the use of a synephrine-containing product by a person without risk factors for coronary artery disease-is to our knowledge the 1st reported in the literature. We discuss the patient's evaluation and clinical course, and we review the literature with respect to synephrine-containing dietary supplements. On the basis of synephrine's chemical composition and mechanism of action, we propose a direct association between this patient's use of Nutrex Lipo-6x (R) and his STEMI. (Tex Heart Inst J 2009;36(6):586-90) C1 [Thomas, John E.; Munir, Jamalah A.] Walter Reed Army Med Ctr, Dept Med Cardiol, Washington, DC 20307 USA. [Ferguson, Michael A.] Natl Naval Med Ctr, Dept Med Cardiol, Bethesda, MD 20899 USA. [McIntyre, Peter Z.] Natl Naval Med Ctr, Dept Med, Bethesda, MD 20899 USA. [Thomas, John E.; Munir, Jamalah A.; Ferguson, Michael A.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Thomas, JE (reprint author), Walter Reed Army Med Ctr, Dept Med Cardiol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM john.thomas4@amedd.army.mil NR 8 TC 22 Z9 23 U1 1 U2 2 PU TEXAS HEART INST PI HOUSTON PA PO BOX 20345, HOUSTON, TX 77225-0345 USA SN 0730-2347 J9 TEX HEART I J JI Tex. Heart Inst. J. PD DEC PY 2009 VL 36 IS 6 BP 586 EP 590 PG 5 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 533EX UT WOS:000272807600014 PM 20069086 ER PT J AU Cox, ED Schreiber, MA McManus, J Wade, CE Holcomb, JB AF Cox, E. Darrin Schreiber, Martin A. McManus, John Wade, Charles E. Holcomb, John B. TI New hemostatic agents in the combat setting SO TRANSFUSION LA English DT Article ID EXTREMITY ARTERIAL HEMORRHAGES; OPERATION-IRAQI-FREEDOM; 2 ADVANCED DRESSINGS; LETHAL GROIN INJURY; VENOUS HEMORRHAGE; HEPATIC-INJURY; ANIMAL-MODEL; SWINE MODEL; BLOOD-LOSS; CHITOSAN AB BACKGROUND: Hemorrhage is a leading cause of potentially preventable death in both civilian and military trauma patients. Animal data have shown that hemostatic bandages reduce hemorrhage and improve survival. This article reports recent clinical observations regarding the efficacy and evolution of use of two new hemostatic bandages employed in the global war on terrorism. METHODS: We performed a retrospective cohort review of soldiers treated with either the QuikClot or HemCon hemostatic bandages between April and October 2006. Hemostatic dressings were placed on wounds either in the field or at the combat support hospital (CSH). RESULTS: During the 6-month study period, 1691 trauma patients were admitted to the CSH. Fifty uses of hemostatic dressings in 44 patients (2.6% of admissions) were identified. Forty patients were treated with HemCon dressings, three patients with QuikClot, and one with both QuikClot and HemCon. Eighteen percent of the dressings were used in the field, predominantly on extremity wounds (7/8). In contrast, most dressings used in the CSH were for truncal wounds (26/36 patients). Hemostatic dressings were applied to extremity wounds in prehospital and hospital settings, either alone or in conjunction with tourniquets. In surviving patients (95%), the treating surgeon determined that the hemorrhage was either stopped or greatly decreased by use of hemostatic dressings. Two of the four patients treated with QuikClot had burns from exothermic reactions, while no adverse reactions were noted with HemCon. CONCLUSIONS: Hemostatic agents stop or decrease bleeding. Whereas HemCon appears to be safe, QuikClot may produce superficial burns. These new hemostatic agents have a place in the surgical armamentarium to assist in controlling internal hemorrhage from truncal and pelvic hemorrhage, especially during damage-control surgery. C1 [Cox, E. Darrin] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Oregon Hlth & Sci Univ, Portland, OR 97201 USA. RP Cox, ED (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. NR 48 TC 51 Z9 52 U1 1 U2 19 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD DEC PY 2009 VL 49 BP 248S EP 255S DI 10.1111/j.1537-2995.2008.01988.x PG 8 WC Hematology SC Hematology GA 527CU UT WOS:000272345000003 PM 19954487 ER PT J AU McLaughlin, DF Wade, CE Champion, HR Salinas, J Holcomb, JB AF McLaughlin, Daniel F. Wade, Charles E. Champion, Howard R. Salinas, Jose Holcomb, John B. TI Thromboembolic complications following trauma SO TRANSFUSION LA English DT Review ID BLUNT CEREBROVASCULAR INJURIES; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; NONINVASIVE SCREENING-TEST; TREATMENT-RELATED OUTCOMES; VENOUS THROMBOEMBOLISM; PULMONARY-EMBOLISM; MAJOR TRAUMA; FACTOR-VIIA; MYOCARDIAL-INFARCTION; UP ARTERIOGRAPHY AB BACKGROUND: Some studies have reported an increased incidence of thomboembolic complications following trauma. STUDY DESIGN AND METHODS: We performed a literature review and queried the National Trauma Data Bank to more closely examine the incidence of a variety of thromboembolic complications following injury. RESULTS: Thromboembolic events are rare, but occur at a greater rate in more severely injured patients. It is unclear, however, whether the incidence of thromboembolic complications in trauma patients is on the rise overall. Differences in study populations, particularly injury severity scores, as well as different methods of screening, diagnosis, prophylaxis, and treatment have led to extreme differences in reported rates. CONCLUSION: While recent research has added to the body of knowledge, continued efforts focusing on risk stratification, diagnosis, screening, prophylaxis, and treatment are necessary to rationally understand the spectrum of thrombotic complications. C1 [Wade, Charles E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Wade, CE (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM charles.wade@amedd.army.mil NR 47 TC 8 Z9 9 U1 0 U2 1 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD DEC PY 2009 VL 49 BP 256S EP 263S DI 10.1111/j.1537-2995.2008.01989.x PG 8 WC Hematology SC Hematology GA 527CU UT WOS:000272345000004 PM 19954488 ER PT J AU Sallum, MAM Dos Santos, CLS Wilkerson, RC AF Mureb Sallum, Maria Anice Dos Santos, Cecilia L. S. Wilkerson, Richard C. TI Studies on Anopheles (Kerteszia) homunculus Komp (Diptera: Culicidae) SO ZOOTAXA LA English DT Article DE Anopheles homunculus; species complex; morphology; ITS2; malaria ID RNA SECONDARY STRUCTURE; MOLECULAR-IDENTIFICATION; WEB SERVER; PREDICTION; OSWALDOI; TRINIDAD; DATABASE; BRAZIL AB The present findings suggest that Anopheles (Kerteszia) homunculus may comprise more than one species. The rDNA ITS2 sequence data corroborate the presence of An. homunculus l.s. in Mata Atlantica, southern Brazil, and suggest that specimens from Trinidad may belong to an unnamed morphologically similar species. There is a need for additional studies to establish the geographical distribution of An. homunculus l.s. in continental South America and in Trinidad, especially in southern Mata Atlantica, Brazil. C1 [Mureb Sallum, Maria Anice] Univ Sao Paulo, Fac Saude Publ, Dept Epidemiol, BR-01246904 Sao Paulo, Brazil. [Wilkerson, Richard C.] Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD 20910 USA. RP Sallum, MAM (reprint author), Univ Sao Paulo, Fac Saude Publ, Dept Epidemiol, Ave Dr Arnaldo 715, BR-01246904 Sao Paulo, Brazil. EM masallum@usp.br; simoes.santos@uol.com.br; wilkersonr@si.edu RI Sallum, Maria/B-8537-2012 FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, FAPESP [05/53973-0]; Conselho Nacional de Desenvolvimento Tecnico e Cient fico (CNPq) [BPP 300351/2008-9] FX We thank David Chadee for hosting the field trip in Trinidad. This investigation was financially support by the Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, FAPESP (Grant 05/53973-0), and Conselho Nacional de Desenvolvimento Tecnico e Cient fico (CNPq BPP 300351/2008-9 to MAMS). We are in debt with two reviewers and Greg Courtney for their great contribution to the improvement of the text. NR 42 TC 5 Z9 5 U1 0 U2 0 PU MAGNOLIA PRESS PI AUCKLAND PA PO BOX 41383, AUCKLAND, ST LUKES 1030, NEW ZEALAND SN 1175-5326 EI 1175-5334 J9 ZOOTAXA JI Zootaxa PD NOV 27 PY 2009 IS 2299 BP 1 EP 18 PG 18 WC Zoology SC Zoology GA 524PQ UT WOS:000272155600001 ER PT J AU Taylor, AJ Villines, TC Stanek, EJ Devine, PJ Griffen, L Miller, M Weissman, NJ Turco, M AF Taylor, Allen J. Villines, Todd C. Stanek, Eric J. Devine, Patrick J. Griffen, Len Miller, Michael Weissman, Neil J. Turco, Mark TI Extended-Release Niacin or Ezetimibe and Carotid Intima-Media Thickness SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; CORONARY-ARTERY-DISEASE; CHOLESTEROL ABSORPTION; ENDOTHELIAL FUNCTION; SCAVENGER RECEPTOR; COLESTIPOL-NIACIN; STATIN THERAPY; HEART-DISEASE; CACO-2 CELLS; ATHEROSCLEROSIS AB BACKGROUND Treatment added to statin monotherapy to further modify the lipid profile may include combination therapy to either raise the high-density lipoprotein (HDL) cholesterol level or further lower the low-density lipoprotein (LDL) cholesterol level. METHODS We enrolled patients who had coronary heart disease or a coronary heart disease risk equivalent, who were receiving long-term statin therapy, and in whom an LDL cholesterol level under 100 mg per deciliter (2.6 mmol per liter) and an HDL cholesterol level under 50 mg per deciliter for men or 55 mg per deciliter for women (1.3 or 1.4 mmol per liter, respectively) had been achieved. The patients were randomly assigned to receive extended-release niacin (target dose, 2000 mg per day) or ezetimibe (10 mg per day). The primary end point was the between-group difference in the change from baseline in the mean common carotid intima-media thickness after 14 months. The trial was terminated early, on the basis of efficacy, according to a prespecified analysis conducted after 208 patients had completed the trial. RESULTS The mean HDL cholesterol level in the niacin group increased by 18.4% over the 14-month study period, to 50 mg per deciliter (P<0.001), and the mean LDL cholesterol level in the ezetimibe group decreased by 19.2%, to 66 mg per deciliter (1.7 mmol per liter) (P<0.001). Niacin therapy significantly reduced LDL cholesterol and triglyceride levels; ezetimibe reduced the HDL cholesterol and triglyceride levels. As compared with ezetimibe, niacin had greater efficacy regarding the change in mean carotid intima-media thickness over 14 months (P=0.003), leading to significant reduction of both mean (P=0.001) and maximal carotid intima-media thickness (P=0.001 for all comparisons). Paradoxically, greater reductions in the LDL cholesterol level in association with ezetimibe were significantly associated with an increase in the carotid intima-media thickness (R=-0.31, P<0.001). The incidence of major cardiovascular events was lower in the niacin group than in the ezetimibe group (1% vs. 5%, P=0.04 by the chi-square test). CONCLUSIONS This comparative-effectiveness trial shows that the use of extended-release niacin causes a significant regression of carotid intima-media thickness when combined with a statin and that niacin is superior to ezetimibe. (ClinicalTrials.gov number, NCT00397657.) C1 [Taylor, Allen J.] Washington Hosp Ctr, Medstar Res Inst, Dept Med Cardiol, Washington, DC 20010 USA. [Taylor, Allen J.; Villines, Todd C.; Devine, Patrick J.; Miller, Michael] Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. [Stanek, Eric J.] Medco Hlth Solut, Franklin Lakes, NJ USA. [Griffen, Len] Cardiac Associates, Rockville, MD USA. [Miller, Michael] Univ Maryland, Med Ctr, Baltimore, MD 21201 USA. [Turco, Mark] Washington Adventist Hosp, Takoma Pk, MD USA. RP Taylor, AJ (reprint author), Washington Hosp Ctr, Medstar Res Inst, Dept Med Cardiol, 110 Irving St NW,Rm 1E12, Washington, DC 20010 USA. EM allen.taylor@medstar.net OI Villines, Todd/0000-0003-2674-3702 FU Abbott FX Supported by Abbott. NR 44 TC 416 Z9 429 U1 11 U2 15 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD NOV 26 PY 2009 VL 361 IS 22 BP 2113 EP 2122 DI 10.1056/NEJMoa0907569 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA 524BC UT WOS:000272117800005 PM 19915217 ER PT J AU Donetsky, D Svensson, SP Vorobjev, LE Belenky, G AF Donetsky, Dmitry Svensson, Stefan P. Vorobjev, Leonid E. Belenky, Gregory TI Carrier lifetime measurements in short-period InAs/GaSb strained-layer superlattice structures SO APPLIED PHYSICS LETTERS LA English DT Article DE carrier density; carrier lifetime; excited states; gallium compounds; III-V semiconductors; indium compounds; molecular beam epitaxial growth; photoluminescence; semiconductor growth; semiconductor superlattices ID RECOMBINATION AB Minority carrier lifetime and interband absorption in midinfrared range of spectra were measured in InAs/GaSb strained-layer superlattices (SLSs) grown by molecular beam epitaxy on GaSb substrates. The carrier lifetime in 200-period undoped 7 ML InAs/8 ML GaSb SLS with AlSb carrier confinement layers was determined by time-resolved photoluminescence (PL) and from analysis of PL response to sinwave-modulated excitation. Study of PL kinetics in frequency domain allowed for direct lifetime measurements with the excess carrier concentration level of 3.5x10(15) cm(-3). The minority carrier lifetime of 80 ns at T=77 K was obtained from dependence of the carrier lifetime on excitation power. C1 [Donetsky, Dmitry; Belenky, Gregory] SUNY Stony Brook, Dept Elect & Comp Engn, Stony Brook, NY 11794 USA. [Svensson, Stefan P.] USA, Res Lab, Adelphi, MD 20783 USA. [Vorobjev, Leonid E.] St Petersburg State Polytech Univ, Dept Semicond Phys & Nanoelect, St Petersburg 195251, Russia. RP Donetsky, D (reprint author), SUNY Stony Brook, Dept Elect & Comp Engn, Stony Brook, NY 11794 USA. EM garik@ece.sunysb.edu FU NVESD; NSF [DMR071054]; RFBR FX The authors acknowledge J. Pellegrino, M. Tidrow, and S. Bandara for support, helpful discussions and encouragement. The study was funded by NVESD and NSF (Award No. DMR071054). L. E. V. appreciates support from the RFBR. NR 5 TC 87 Z9 87 U1 6 U2 24 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD NOV 23 PY 2009 VL 95 IS 21 AR 212104 DI 10.1063/1.3267103 PG 3 WC Physics, Applied SC Physics GA 534KL UT WOS:000272895100020 ER PT J AU Galan, PP Chapman, CM Gibellini, F Liu, P Raghavachari, N Roschewski, M Wiestner, A AF Galan, Patricia Perez Chapman, Colby M. Gibellini, Federica Liu, Poching Raghavachari, Nalini Roschewski, Mark Wiestner, Adrian TI The PI3K Inhibitor ON 01910.Na Inhibits Critical Survival Pathways and Induces Apoptosis in CLL Cells through Induction of NOXA and BIM SO BLOOD LA English DT Meeting Abstract CT 51st Annual Meeting of the American-Society-of-Hematology CY DEC 05-08, 2009 CL New Orleans, LA SP Amer Soc Hematol C1 [Galan, Patricia Perez; Chapman, Colby M.; Gibellini, Federica; Wiestner, Adrian] NHLBI, Hematol Branch, NIH, Bethesda, MD 20892 USA. [Liu, Poching; Raghavachari, Nalini] NHLBI, Genom Core Facil, NIH, Bethesda, MD 20892 USA. [Roschewski, Mark] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 20 PY 2009 VL 114 IS 22 BP 171 EP 172 PG 2 WC Hematology SC Hematology GA 532DS UT WOS:000272725800413 ER PT J AU Landgren, O Devesa, S Mink, P Anderson, WF Weiss, B Kristinsson, SY McGlynn, K AF Landgren, Ola Devesa, Susan Mink, Pamela Anderson, William F. Weiss, Brendan Kristinsson, Sigurdur Y. McGlynn, Katherine TI African-American Multiple Myeloma Patients Have a Better Survival Than Caucasian Patients: a Population-Based Study Including 28,636 Patients SO BLOOD LA English DT Meeting Abstract CT 51st Annual Meeting of the American-Society-of-Hematology CY DEC 05-08, 2009 CL New Orleans, LA SP Amer Soc Hematol C1 [Landgren, Ola] NCI, Med Oncol Branch, NIH, Bethesda, MD 20892 USA. [Devesa, Susan; Anderson, William F.; McGlynn, Katherine] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. [Mink, Pamela] Emory Univ, Atlanta, GA 30322 USA. [Weiss, Brendan] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Kristinsson, Sigurdur Y.] Karolinska Univ Hosp & Inst, Div Hematol, Dept Med, Stockholm, Sweden. RI Kristinsson, Sigurdur /M-2910-2015 OI Kristinsson, Sigurdur /0000-0002-4964-7476 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 20 PY 2009 VL 114 IS 22 BP 727 EP 727 PG 1 WC Hematology SC Hematology GA 532DS UT WOS:000272725802200 ER PT J AU Weiss, B Minter, A Laquer, M Howard, R Abadie, J Ascencao, J Schechter, GP Kuehl, M Landgren, O AF Weiss, Brendan Minter, Alex Laquer, Matthew Howard, Robin Abadie, Jude Ascencao, Joao Schechter, Geraldine P. Kuehl, Michael Landgren, Ola TI Patterns of Monoclonal Immunoglobulins and Serum Free Light Chains Are Significantly Different in African-American Compared to Caucasian MGUS Patients SO BLOOD LA English DT Meeting Abstract CT 51st Annual Meeting of the American-Society-of-Hematology CY DEC 05-08, 2009 CL New Orleans, LA SP Amer Soc Hematol C1 [Weiss, Brendan; Minter, Alex] Walter Reed Army Med Ctr, Hematol Oncol Serv, Washington, DC 20307 USA. [Abadie, Jude] Walter Reed Army Med Ctr, Pathol & Area Lab Serv, Washington, DC 20307 USA. [Ascencao, Joao] Washington DC Vet Affairs Med Ctr, Hematol Serv, Washington, DC USA. [Schechter, Geraldine P.] Washington VA Med Ctr, Washington, DC USA. [Schechter, Geraldine P.] George Washington Univ, Washington, DC USA. [Kuehl, Michael] NCI, Genet Branch, Canc Res Ctr, Bethesda, MD 20892 USA. [Landgren, Ola] NCI, Med Oncol Branch, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 20 PY 2009 VL 114 IS 22 BP 1108 EP 1109 PG 2 WC Hematology SC Hematology GA 532DS UT WOS:000272725803393 ER PT J AU Brown, P Hilden, JM Dreyer, ZE Winick, NJ Salzer, W Raetz, E Sung, L Zaoutis, TE Jones, T Devidas, M De Lorenzo, P Valsecchi, MG Pieters, R Carroll, WL Hunger, SP AF Brown, Patrick Hilden, Joanne M. Dreyer, Zoann E. Winick, Naomi J. Salzer, Wanda Raetz, Elizabeth Sung, Lillian Zaoutis, Theoklis E. Jones, Tamekia Devidas, Meenakshi De Lorenzo, Paola Valsecchi, Maria Grazia Pieters, Rob Carroll, William L. Hunger, Stephen P. TI Report On Excessive Induction Toxicity in Infants with ALL Enrolled On COG Protocol AALL0631: A Children's Oncology Group Study. SO BLOOD LA English DT Meeting Abstract CT 51st Annual Meeting of the American-Society-of-Hematology CY DEC 05-08, 2009 CL New Orleans, LA SP Amer Soc Hematol C1 [Brown, Patrick] Johns Hopkins Univ, Baltimore, MD USA. [Hilden, Joanne M.] Peyton Manning Childrens Hosp St Vincent, Indianapolis, IN USA. [Dreyer, Zoann E.] Texas Childrens Canc Ctr, Houston, TX USA. [Winick, Naomi J.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA. [Salzer, Wanda] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Raetz, Elizabeth] NYU, Langone Med Ctr, New York, NY USA. [Sung, Lillian] Hosp Sick Children, Toronto, ON M5G 1X8, Canada. [Zaoutis, Theoklis E.] Univ Penn, Childrens Hosp Philadelphia, Sch Med, Philadelphia, PA 19104 USA. [Jones, Tamekia; Devidas, Meenakshi] Childrens Oncol Grp, Dept Epidemiol & Hlth Policy Res, Gainesville, FL USA. [Devidas, Meenakshi] Univ Florida, Coll Med, Gainesville, FL USA. [De Lorenzo, Paola] Univ Milano Bicocca, Interfant Trial Data Ctr, Dept Clin Med & Prevent, Monza, Italy. [Valsecchi, Maria Grazia] Univ Milano Bicocca, Dept Clin & Prevent Med, Monza, Italy. [Pieters, Rob] Sophia Childrens Univ Hosp, Erasmus MC, Rotterdam, Netherlands. [Carroll, William L.] NYU, Inst Canc, New York, NY USA. [Hunger, Stephen P.] Univ Colorado, Coll Med, Aurora, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 20 PY 2009 VL 114 IS 22 BP 1202 EP 1202 PG 1 WC Hematology SC Hematology GA 532DS UT WOS:000272725803646 ER PT J AU Aue, G Soto, S Valdez, J Arthur, DC Roschewski, M Wiestner, A AF Aue, Georg Soto, Susan Valdez, Janet Arthur, Diane C. Roschewski, Mark Wiestner, Adrian TI A Phase II Trial of Pulse Dosing Lenalidomide: 3 Weeks On 3 Weeks off in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma. SO BLOOD LA English DT Meeting Abstract CT 51st Annual Meeting of the American-Society-of-Hematology CY DEC 05-08, 2009 CL New Orleans, LA SP Amer Soc Hematol C1 [Aue, Georg; Soto, Susan; Valdez, Janet; Wiestner, Adrian] NHLBI, Hematol Branch, NIH, Bethesda, MD 20892 USA. [Arthur, Diane C.] NCI, Pathol Lab, Bethesda, MD 20892 USA. [Roschewski, Mark] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 20 PY 2009 VL 114 IS 22 BP 1331 EP 1331 PG 1 WC Hematology SC Hematology GA 532DS UT WOS:000272725804092 ER PT J AU Marshall, HP Johnson, JB AF Marshall, Hans-Peter Johnson, Jerome B. TI Accurate inversion of high-resolution snow penetrometer signals for microstructural and micromechanical properties SO JOURNAL OF GEOPHYSICAL RESEARCH-EARTH SURFACE LA English DT Article ID HARDNESS; ICE AB Measurements of snow using a high-resolution micropenetrometer can be used to discriminate between different snow types; in lower-density snow the signal is sensitive to microstructure, and micromechanical properties can be estimated. Although a physics-based snow penetration theory was first developed almost a decade ago, since that time the majority of studies using snow micropenetrometers have focused on using direct hardness measurements in statistical relationships. We use Monte-Carlo simulations to rigorously test the existing physics-based snow micropenetration theories over a wide range of parameters. These tests revealed four major sources of error in the inversion, which are corrected in this analysis. It is shown that this improved inversion algorithm can recover micromechanical parameters in synthetic data with much greater accuracy over the entire range of micromechanical properties observed in natural snow. Detailed examples of the inversion results are shown for eight different snow types, collected in both Alaskan and alpine snowpacks. The resulting micromechanical properties are distinctly different, indicating that a snow characterization from snow micropenetrometer estimates of micromechanical properties is likely possible. Estimates of the microscale elastic modulus, microscale strength, and structural element length make sense physically when compared to the qualitative descriptions of the different snow types. Microscale strength estimates are used to estimate macroscale strength values, and results from 33 different snow samples, covering a wide range of densities and snow types, are consistent with previously reported values from macroscale tests. C1 [Marshall, Hans-Peter] Boise State Univ, Dept Geosci, Ctr Geophys Investigat Shallow Subsurface, Boise, ID 83725 USA. [Johnson, Jerome B.] Univ Alaska Fairbanks, Inst No Engn, Fairbanks, AK 99775 USA. [Marshall, Hans-Peter] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Marshall, HP (reprint author), Boise State Univ, Dept Geosci, Ctr Geophys Investigat Shallow Subsurface, 1910 Univ Dr,MG206E, Boise, ID 83725 USA. EM hpm@cgiss.boisestate.edu RI Marshall, Hans-Peter/A-2374-2010 OI Marshall, Hans-Peter/0000-0002-4852-5637 NR 27 TC 26 Z9 26 U1 0 U2 10 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0148-0227 J9 J GEOPHYS RES-EARTH JI J. Geophys. Res.-Earth Surf. PD NOV 20 PY 2009 VL 114 AR F04016 DI 10.1029/2009JF001269 PG 18 WC Geosciences, Multidisciplinary SC Geology GA 522KO UT WOS:000271996900001 ER PT J AU Brosten, TR Codd, SL Maier, RS Seymour, JD AF Brosten, Tyler R. Codd, Sarah L. Maier, Robert S. Seymour, Joseph D. TI Dynamic Length-Scale Characterization and Nonequilibrium Statistical Mechanics of Transport in Open-Cell Foams SO PHYSICAL REVIEW LETTERS LA English DT Article ID POROUS-MEDIA; DISPERSION; FLOW; NMR; DIFFUSION; FLUID AB Nuclear magnetic resonance measurements of scale dependent dynamics in a random solid open-cell foam reveal a characteristic length scale for transport processes in this novel type of porous medium. These measurements and lattice Boltzmann simulations for a model foam structure indicate dynamical behavior analogous to lower porosity consolidated granular porous media, despite extremely high porosity in solid cellular foams. Scaling by the measured characteristic length collapses data for different foam structures as well as consolidated granular media. The nonequilibrium statistical mechanics theory of preasymptotic dispersion, developed for hierarchical porous media, is shown to model the hydrodynamic dispersive transport in a foam structure. C1 [Brosten, Tyler R.; Codd, Sarah L.] Montana State Univ, Dept Mech & Ind Engn, Bozeman, MT 59717 USA. [Maier, Robert S.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Seymour, Joseph D.] Montana State Univ, Dept Chem & Biol Engn, Bozeman, MT 59717 USA. RP Brosten, TR (reprint author), Montana State Univ, Dept Mech & Ind Engn, Bozeman, MT 59717 USA. EM jseymour@coe.montana.edu RI Seymour, Joseph/E-8518-2012; Codd, Sarah/F-1639-2013 OI Seymour, Joseph/0000-0003-4264-5416; FU NSF [CBET-0642328, CTS-0348076]; DOE OS BER [DE-FG02-07-ER-64416] FX R. S. M. and J. D. S. gratefully acknowledge formative discussions with the late H. Ted Davis, on the dynamics of transport in porous media. Research supported by NSF CBET-0642328 (S. L. C.) and CTS-0348076 (J. D. S.), DOE OS BER DE-FG02-07-ER-64416 (J. D. S. and S. L. C.). NR 28 TC 9 Z9 9 U1 1 U2 14 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD NOV 20 PY 2009 VL 103 IS 21 AR 218001 DI 10.1103/PhysRevLett.103.218001 PG 4 WC Physics, Multidisciplinary SC Physics GA 523EH UT WOS:000272054300050 PM 20366068 ER PT J AU Laoire, CO Mukerjee, S Abraham, KM Plichta, EJ Hendrickson, MA AF Laoire, Cormac O. Mukerjee, Sanjeev Abraham, K. M. Plichta, Edward J. Hendrickson, Mary A. TI Elucidating the Mechanism of Oxygen Reduction for Lithium-Air Battery Applications SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID ELECTRODE-REACTION; DIOXYGEN; SOLVENTS; MEDIA AB Unlocking the true energy capabilities of the lithium metal negative electrode in a lithium battery has until now been limited by the low capacity intercalation and conversion reactions at the positive electrodes. Abraham et al. (Abraham, K. M.; Jiang, Z. J. Electrochem. Soc. 1996, 143, 1-5) overcame this limitation by removing these electrodes and allowing lithium to react directly with oxygen in the atmosphere, forming the Li-air battery. The Li/O(2) battery redox couple has a theoretical specific energy of 5200 W h/kg and represents the ultimate, environmentally friendly electrochemical power source. In this work, we report for the first time the intimate role of electrolyte, in particular the role of ion conducting salt:, in determining the reversibility and kinetics of oxygen reduction in nonaqueous electrolytes designed for such applications. Such fundamental understanding of this high energy density battery is crucial to harnessing its full energy potential. The kinetics and mechanisms of O(2) reduction in solutions of hexafluorophosphate of the general formula A(+)PF(6)(-), where A = tetrabutylammonium (TBA), K, Na, and Li, in acetonitrile are reported on glassy carbon electrodes using cyclic voltammetry (CV) and rotating disk electrode (RDE) techniques, The results show that the cations in the electrolyte strongly influence the reduction mechanism Of O(2). Larger cations represented by TBA salts displayed reversible O(2)/O(2)(-) redox couple, in contrast to those containing the smaller Li (and other alkali metal) cations, where an irreversible one-electron reduction of O(2) to LiO(2), and other alkali metal superoxides, is shown to occur as the first process. It was also found the LiO(2) formed initially decomposes to Li(2)O(2). Electrochemical data support the view that alkali metal oxides formed via electrochemical and chemical reactions passivate the electrode surface, making the processes irreversible. The O(2) reduction mechanisms in the presence of the different cations have been supplemented by kinetic parameters determined from detailed analyses of the CV and RDE data. The Lewis acid characteristics of the cation appear to be crucial in determining the reversibility of the system. The results of this study are expected to contribute to the rapid development of the Li-air battery. C1 [Laoire, Cormac O.; Mukerjee, Sanjeev; Abraham, K. M.] Northeastern Univ, Dept Chem & Biol Chem, Boston, MA 02115 USA. [Plichta, Edward J.; Hendrickson, Mary A.] USA, CERDEC, Army Power Div, Ft Monmouth, NJ 07703 USA. RP Abraham, KM (reprint author), Northeastern Univ, Dept Chem & Biol Chem, 360 Huntington Ave, Boston, MA 02115 USA. EM kmabraham@comcast.net FU U.S. Army CERDEC [GTS-S-6-1-437] FX U.S. Army CERDEC through Subcontract No. GTS-S-6-1-437 supported this work. NR 15 TC 343 Z9 349 U1 43 U2 350 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD NOV 19 PY 2009 VL 113 IS 46 BP 20127 EP 20134 DI 10.1021/jp908090s PG 8 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 516ZX UT WOS:000271583600048 ER PT J AU Krishnan, R Parker, T Lee, S Lu, TM AF Krishnan, R. Parker, T. Lee, S. Lu, T-M TI The formation of vertically aligned biaxial tungsten nanorods using a novel shadowing growth technique SO NANOTECHNOLOGY LA English DT Article ID ANGLE SPUTTER-DEPOSITION; CHROMIUM THIN-FILMS; PHASE-TRANSFORMATION; SUBSTRATE; TEXTURE; MICROSTRUCTURE; DEPENDENCE; BICRYSTALS; MECHANISM; ALIGNMENT AB Biaxially textured tungsten nanorods (A15 crystal structure) have been grown by oblique angle DC magnetron sputtering using a novel rotation mode called 'two-step rotation'. In this mode, the substrate is given a fast rotation through 180 degrees at 90 rpm and this is followed by a rest period of 30 s. These nanorods are vertically aligned and have a [100] texture normal to the substrate along with preferential in-plane texture as shown by x-ray pole figure analysis. In contrast, the tungsten nanorods obtained without substrate rotation are slanted at an angle of similar to 45 degrees and have a [100] texture tilted 16 degrees with respect to the substrate normal. The flux is incident from two diametrically opposite points on the sample at an oblique angle, averaging out the growth into vertical columns that retain the in-plane texture. Scanning electron microscopy shows that the tungsten nanorods have a mixture of {211} and {421} crystal habits; these planes are both minimum surface energy planes for a cubic A15 crystal structure. C1 [Krishnan, R.] Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA. [Parker, T.; Lu, T-M] Rensselaer Polytech Inst, Dept Phys Appl Phys & Astron, Troy, NY 12180 USA. [Lee, S.] USA, Armament Res Dev & Engn Ctr, Benet Labs, Watervliet, NY 12189 USA. RP Krishnan, R (reprint author), Rensselaer Polytech Inst, Dept Mat Sci & Engn, 110 8th St, Troy, NY 12180 USA. FU NSF NIRT [0506738]; NSF IGERT FX This work is supported by NSF NIRT 0506738. TP is an NSF IGERT fellow. NR 28 TC 6 Z9 6 U1 0 U2 15 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND SN 0957-4484 J9 NANOTECHNOLOGY JI Nanotechnology PD NOV 18 PY 2009 VL 20 IS 46 AR 465609 DI 10.1088/0957-4484/20/46/465609 PG 6 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA 509PL UT WOS:000271030200024 PM 19847032 ER PT J AU Lettieri, CJ Shah, AA Holley, AB Kelly, WF Chang, AS Roop, SA AF Lettieri, Christopher J. Shah, Anita A. Holley, Aaron B. Kelly, William F. Chang, Audrey S. Roop, Stuart A. CA CPAP ASAP Trial TI Effects of a Short Course of Eszopiclone on Continuous Positive Airway Pressure Adherence A Randomized Trial SO ANNALS OF INTERNAL MEDICINE LA English DT Article ID OBSTRUCTIVE SLEEP-APNEA; NASAL CPAP THERAPY; QUALITY-OF-LIFE; 1ST 3 MONTHS; APNOEA/HYPOPNOEA SYNDROME; APNEA/HYPOPNEA SYNDROME; PATIENT COMPLIANCE; HYPERTENSION; ASSOCIATION; VARIABILITY AB Background: Adherence to short-term continuous positive airway pressure (CPAP) may predict long-term use. Unfortunately, initial CPAP intolerance may lead to poor adherence or abandonment of therapy. Objective: To determine whether a short course of eszopiclone at the onset of therapy improves long-term CPAP adherence more than placebo in adults with obstructive sleep apnea. Design: Parallel randomized, placebo-controlled trial from March 2007 to December 2008. Randomization, maintained and concealed centrally by pharmacy personnel, was computer-generated using fixed blocks of 10. Referring physicians, investigators, and patients were blinded to the treatment assignment until after the final data were collected. (ClinicalTrials.gov registration number: NCT00612157) Setting: Academic sleep disorder center. Patients: 160 adults (mean age, 45.7 years [SD, 7.3]; mean apnea-hypopnea index, 36.9 events/h [ SD, 23]) with newly diagnosed obstructive sleep apnea initiating CPAP. Intervention: Eszopiclone, 3 mg (n = 76), or matching placebo (n = 78) for the first 14 nights of CPAP. Measurements: Use of CPAP was measured weekly for 24 weeks. Adherence to CPAP (primary outcome) and the rate of CPAP discontinuation and improvements in symptoms (secondary outcomes) were compared. Follow-up at 1, 3, and 6 months was completed by 150, 136, and 120 patients, respectively. Results: Patients in the eszopiclone group used CPAP for 20.8% more nights (95% CI, 7.2% to 34.4%; P = 0.003), 1.3 more hours per night for all nights (CI, 0.4 to 2.2 hours; P = 0.005), and 1.1 more hours per night of CPAP use (CI, 0.2 to 2.1 hours; P = 0.019). The hazard ratio for discontinuation of CPAP was 1.90 (CI, 1.1 to 3.4; P = 0.033) times higher in the placebo group. Side effects were reported in 7.1% of patients and did not differ between groups. Limitations: Patients had severe obstructive sleep apnea treated at a specialized sleep center with frequent follow-up; results may not be generalizable to different settings. Patients' tolerance to CPAP and their reasons for discontinuation were not assessed. Conclusion: Compared with placebo, a short course of eszopiclone during the first 2 weeks of CPAP improved adherence and led to fewer patients discontinuing therapy. C1 [Lettieri, Christopher J.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Lettieri, CJ (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave,NW, Washington, DC 20307 USA. EM christopher.lettieri@us.army.mil FU Henry M. Jackson Foundation for the Advancement of Military Medicine FX By Sepracor to the Henry M. Jackson Foundation for the Advancement of Military Medicine. NR 33 TC 43 Z9 47 U1 0 U2 4 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 USA SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD NOV 17 PY 2009 VL 151 IS 10 BP 696 EP W225 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 524LP UT WOS:000272145100003 PM 19920270 ER PT J AU Dong, LB Carbonell, RG Roberts, GW Kiserow, DJ AF Dong, Laura Beth Carbonell, Ruben G. Roberts, George W. Kiserow, Douglas J. TI Determination of polystyrene-carbon dioxide-decahydronaphthalene solution properties by high pressure dynamic light scattering SO POLYMER LA English DT Article DE Polystyrene; Diffusion; Dynamic light scattering ID HETEROGENEOUS CATALYTIC-HYDROGENATION; X-RAY-SCATTERING; TRANS-DECALIN; CO2-EXPANDED SOLVENTS; REFRACTIVE-INDEX; DILUTE-SOLUTIONS; SYSTEMS; CONFORMATION; TEMPERATURE; BEHAVIOR AB The diffusion coefficients of polystyrene (PS) in decahydronaphthalene (DHN) and in solutions of carbon dioxide (CO(2)) and DHN were measured for dilute PS solutions over a range of temperatures and CO(2)-DHN ratios using high pressure dynamic light scattering. Infinite dilution diffusion coefficients (DO) of PS and dynamic second virial coefficients (k(D)) were determined for essentially monodisperse 308 kDa PS. At a system pressure of 20.7 MPa, PS diffusion coefficients increased by a factor of 2.5, and the activation energy of diffusion decreased by approximately 16% when DHN was "expanded" with 44 mol% CO(2). However, the hydrodynamic radius of PS at a given temperature was not particularly sensitive to the CO(2) concentration. Solvent quality, as measured by kD, decreased at higher CO(2) concentrations. The addition of CO(2) to polymer solutions may offer a way to "tune" the properties of the solution to facilitate the heterogeneous catalytic hydrogenation of polymers. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Dong, Laura Beth; Carbonell, Ruben G.; Roberts, George W.; Kiserow, Douglas J.] N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA. [Kiserow, Douglas J.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Roberts, GW (reprint author), N Carolina State Univ, Dept Chem & Biomol Engn, Campus Box 7905, Raleigh, NC 27695 USA. EM groberts@eos.ncsu.edu FU United States Army Research Office [W911NF-04-D-0003]; National Science Foundation [CHE-9876674] FX The authors would like to thank Dr. John H. van Zanten of North Carolina State University for the helpful discussions. This research was supported by Contract W911NF-04-D-0003 from the United States Army Research Office, Research Triangle Park, NC. Partial support was also provided by the STC Program of the National Science Foundation under Agreement No. CHE-9876674. This material is also based upon work supported under a National Science Foundation Graduate Research Fellowship (LBD). NR 27 TC 5 Z9 5 U1 2 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 J9 POLYMER JI Polymer PD NOV 16 PY 2009 VL 50 IS 24 BP 5728 EP 5732 DI 10.1016/j.polymer.2009.09.069 PG 5 WC Polymer Science SC Polymer Science GA 524DV UT WOS:000272124900016 ER PT J AU Keiser, PB Miller, LB Biggs-Cicatelli, S Zollinger, WD AF Keiser, Paul B. Miller, Lori B. Biggs-Cicatelli, Susan Zollinger, Wendell D. TI Plasma fibrinogen levels after vaccination with a native outer membrane vesicle vaccine for Neisseria meningitidis SO VACCINE LA English DT Article DE Fibrinogen; Vaccine; Neisseria meningitidis; OMV ID C-REACTIVE PROTEIN; YELLOW-FEVER VACCINATION; INFLUENZA VACCINATION; MYOCARDIAL-INFARCTION; CARDIOVASCULAR RISK; ASSOCIATION; MORTALITY; ANTIBODY AB Several studies have shown plasma fibrinogen increases following some vaccinations, but the specific triggers and the kinetics of this response are not well understood. We conducted a phase I trial of an outer membrane vesicle vaccine for Neisseria meningitidis. Plasma fibrinogen was measured on days 0, 2 and 14 following each of 3 doses. The highest dose of vaccine was associated with the greatest increase in fibrinogen at day 2, which decreased by day 14. The first vaccination caused a greater increase than either subsequent vaccination. These transient increases in fibrinogen are comparable to what occurs with upper respiratory infections and have not been demonstrated to represent an increased risk of adverse vascular events. Published by Elsevier Ltd. C1 [Keiser, Paul B.; Miller, Lori B.; Biggs-Cicatelli, Susan; Zollinger, Wendell D.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Keiser, PB (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM paul.keiser@us.army.ml RI Zollinger, Wendell/B-2887-2011 NR 25 TC 5 Z9 5 U1 2 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD NOV 16 PY 2009 VL 27 IS 49 BP 6809 EP 6813 DI 10.1016/j.vaccine.2009.09.019 PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 524DM UT WOS:000272124000003 PM 19761833 ER PT J AU Martin, SS Bakken, RR Lind, CM Reed, DS Price, JL Koeller, CA Parker, MD Hart, MK Fine, DL AF Martin, Shannon S. Bakken, Russell R. Lind, Cathleen M. Reed, Douglas S. Price, Jessica L. Koeller, Craig A. Parker, Michael D. Hart, Mary Kate Fine, Donald L. TI Telemetric analysis to detect febrile responses in mice following vaccination with a live-attenuated virus vaccine SO VACCINE LA English DT Article DE Vaccine; Mouse; Telemetry ID VENEZUELAN EQUINE ENCEPHALITIS; BODY-TEMPERATURE; HEART-RATE; NONHUMAN-PRIMATES; CANDIDATE V3526; PROTECTION; AEROSOL; SINGLE; NEUROVIRULENCE; CHALLENGE AB Non-human primates (NHP) are considered to be the most appropriate model for predicting how humans will respond to many infectious diseases. Due to ethical and monetary concerns associated with the use of NHP, rodent models that are as predictive of responses likely to be seen in human vaccine recipients are warranted. Using implanted telemetry devices, body temperature and activity were monitored in inbred and outbred mouse strains following administration of the live-attenuated vaccine for Venezuelan equine encephalitis virus (VEEV), V3526. Following analysis of individual mouse data, only outbred mouse strains showed changes in diurnal temperature and activity profiles following vaccination. Similar changes were observed following VEEV challenge of vaccinated outbred mice. From these studies, we conclude, outbred mouse strains implanted with telemeters are a sensitive model for predicting responses in humans following vaccination. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Martin, Shannon S.; Price, Jessica L.; Hart, Mary Kate; Fine, Donald L.] CSC Co, DynPort Vaccine Co LLC, Frederick, MD 21702 USA. [Bakken, Russell R.; Lind, Cathleen M.; Parker, Michael D.] USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA. [Reed, Douglas S.] Univ Pittsburgh, Dept Immunol, Ctr Vaccine Res, Pittsburgh, PA 15261 USA. RP Martin, SS (reprint author), CSC Co, DynPort Vaccine Co LLC, 64 Thomas Johnson Dr, Frederick, MD 21702 USA. EM smartin40@csc.com OI Reed, Douglas/0000-0003-0076-9023 FU National Institute of Allergy and Infectious Diseases [1UC1AI062538-01]; Joint Science and Technology Office-Chemical; Biological Defense Plan [1.1C0041-09-RD-B] FX research described herein was sponsored by the National Institute of Allergy and Infectious Diseases Grant Number 1UC1AI062538-01 and the Joint Science and Technology Office-Chemical, Biological Defense Plan 1.1C0041-09-RD-B. NR 29 TC 12 Z9 12 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD NOV 16 PY 2009 VL 27 IS 49 BP 6814 EP 6823 DI 10.1016/j.vaccine.2009.09.013 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 524DM UT WOS:000272124000004 PM 19761841 ER PT J AU Steers, NJ Peachman, KK McClain, S Alving, CR Rao, M AF Steers, Nicholas J. Peachman, Kristina K. McClain, Sasha Alving, Carl R. Rao, Mangala TI Liposome-encapsulated HIV-1 Gag p24 containing lipid A induces effector CD4+T-cells, memory CD8+T-cells, and pro-inflammatory cytokines SO VACCINE LA English DT Article DE Liposomal lipid A; Memory CD8+T-cells; Effector CD4+T-cells ID CD8(+) T-CELLS; HUMAN DENDRITIC CELLS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; ANTIGEN PRESENTATION; ACUTE INFECTION; PROTECTIVE IMMUNITY; IN-VIVO; RESPONSES; VACCINE; MACROPHAGES AB Liposomal lipid A is an effective adjuvant for the delivery of antigens and for the induction of both cellular and humoral immunity. In this study, we demonstrate that following the third immunization with HIV-1 Gag p24 encapsulated in liposomes containing lipid A [L(p24+ LA)], central memory CD8+ T-cells were localized in the spleen and lymph nodes of mice while effector memory CD8+ T-cells and effector CD4+ T-cells were found in the PBMC. Effector CD4+ T-cells were also detected in the spleen and lymph nodes. The predominant cytokine secreted from splenic lymphocytes and lymph nodes was IFN-gamma. In contrast, IL-6 and IL-10 were the major cytokines produced from PBMC. The peptide stimulation indicated that the cytokine responses observed were T-cell specific. The results demonstrate the importance of the adjuvant liposomal lipid A for the induction of HIV-1 Gag p24-specific CD8+ T-cells, effector CD4+ T-cells, and cytokines with a Th-1 type profile after immunization with L(p24 + LA). Published by Elsevier Ltd. C1 [Steers, Nicholas J.; Peachman, Kristina K.; McClain, Sasha; Alving, Carl R.; Rao, Mangala] Walter Reed Army Inst Res, USMHRP, Div Retrovirol, Rockville, MD 20850 USA. RP Rao, M (reprint author), Walter Reed Army Inst Res, USMHRP, Div Retrovirol, 1600 E Gude Dr, Rockville, MD 20850 USA. EM mrao@hivresearch.org FU Walter Reed Army Institute of Research FX This work was supported by an in-house-laboratory independent research award from the Walter Reed Army Institute of Research. We would like to thank Ms. Elaine Morrison for help with the animal studies.; Conflict of interest: The authors have no financial conflicts of interest. NR 73 TC 16 Z9 17 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD NOV 16 PY 2009 VL 27 IS 49 BP 6939 EP 6949 DI 10.1016/j.vaccine.2009.08.105 PG 11 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 524DM UT WOS:000272124000020 PM 19748578 ER PT J AU Strigul, N Vaccari, L Galdun, C Wazne, M Liu, X Christodoulatos, C Jasinkiewicz, K AF Strigul, Nikolay Vaccari, Liana Galdun, Catherine Wazne, Mahmoud Liu, Xuyang Christodoulatos, Christos Jasinkiewicz, Kristin TI Acute toxicity of boron, titanium dioxide, and aluminum nanoparticles to Daphnia magna and Vibrio fischeri SO DESALINATION LA English DT Article; Proceedings Paper CT 9th International Conference on Protection and Restoration of the Environment CY JUN 30-JUL 03, 2008 CL Kefalonia, GREECE DE nanomaterials; acute toxicity; boron nanoparticles; aluminum nanoparticles; titanium dioxide nanoparticles; Daphnia magna test; Vibrio fischeri test ID SAND COLUMNS; NANOMATERIALS; ECOTOXICOLOGY; SUSPENSIONS; ORGANISMS; TRANSPORT; MODEL; TIO2 AB The acute toxicity of four different nanosized particulate materials (titanium dioxide, boron nanoparticles, and two types of aluminum nanoparticles (ALEX and L-ALEX)) were evaluated using two tests: the Microtox toxicity test and the acute toxicity test with Daphnia magna. The results were analyzed in order to calculate LD(50) at 24 and 48 h. It was found that titanium dioxide nanoparticles show a low level of toxicity, and LD(50) values cannot be calculated. Conversely, boron nanoparticles with EC(50) ranging from 56 to 66 mg L(-1), depending upon the age of the solution, can be classified as "harmful" to aquatic microorganisms (EC(50) in the range 10-100 mg L(-1)). We have also discussed possible mechanisms of nanoparticle toxicity and potential problems in ecotoxicological testing of nanomaterials. The studied nanomaterials can be ranked in the following order according to their Daphnia acute toxicity: boron nanoparticles>ALEX>L-ALEX> TiO(2). C1 [Strigul, Nikolay; Vaccari, Liana; Galdun, Catherine; Wazne, Mahmoud; Liu, Xuyang; Christodoulatos, Christos] Stevens Inst Technol, Ctr Environm Syst, Hoboken, NJ 07030 USA. [Jasinkiewicz, Kristin] USA, RDECOM ARDEC, Environm Technol Div, Picatinny Arsenal, NJ 07806 USA. RP Strigul, N (reprint author), Stevens Inst Technol, Ctr Environm Syst, Castle Point Hudson, Hoboken, NJ 07030 USA. EM nstrigul@stevens.edu RI Liu, Xuyang/F-3373-2011; Strigul, Nick/C-3987-2016 NR 25 TC 53 Z9 57 U1 3 U2 47 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0011-9164 J9 DESALINATION JI Desalination PD NOV 15 PY 2009 VL 248 IS 1-3 BP 771 EP 782 DI 10.1016/j.desal.2009.01.013 PG 12 WC Engineering, Chemical; Water Resources SC Engineering; Water Resources GA 511CJ UT WOS:000271141200101 ER PT J AU Hulten, E Mitchell, J Scally, J Gibbs, B Villines, TC AF Hulten, E. Mitchell, J. Scally, J. Gibbs, B. Villines, T. C. TI HIV positivity, protease inhibitor exposure and subclinical atherosclerosis: a systematic review and meta-analysis of observational studies SO HEART LA English DT Article ID INTIMA-MEDIA THICKNESS; HUMAN-IMMUNODEFICIENCY-VIRUS; ACTIVE ANTIRETROVIRAL THERAPY; CARDIOVASCULAR RISK-FACTORS; CORONARY-HEART-DISEASE; INFECTED PATIENTS; MYOCARDIAL-INFARCTION; PREMATURE ATHEROSCLEROSIS; COMPUTED-TOMOGRAPHY; INSULIN-RESISTANCE AB Context: Patients with HIV may have increased risk of atherosclerotic cardiovascular disease owing to multiple biological mechanisms. Objective: To evaluate the evidence for subclinical atherosclerosis among patients with HIV. Design: Systematic review of observational studies. Data sources: We searched Medline, Cochrane DSR, ACP Journal Club, DARE, CMR, HTA, NHSEED, Embase and the Cochrane Controlled Trials Register for studies published before November 2008. Study selection: Eligible studies were cross-sectional, cohort, or case-control studies reporting carotid ultrasound intima-media thickness (CIMT), focal plaque incidence, or coronary artery calcium (CAC), as determined by HIV positivity or protease inhibitor (PI) exposure. Data extraction: Two independent reviewers abstracted data using a standardised form. The primary outcome was weighted mean difference (WMD) for CIMT comparing HIV positive versus negative patients. Other outcomes included WMD by PI exposure and the odds ratio (OR) for a focal carotid plaque or CAC. Data from six cross-sectional, seven case-control and 13 cohort studies were included, involving 5456 HIV positive and 3600 HIV negative patients. Results: The weighted mean CIMT was 0.04 mm thicker among patients with HIV than among non-HIV patients (95% CI 0.02 to 0.06; p < 0.001). HIV positivity was not associated with carotid plaque or CAC. PI exposure did not significantly affect CIMT, carotid plaque, or CAC. There was evidence of publication bias and stratified analysis and meta-regression showed outcomes were influenced by study design, age, gender and smoking. However, HIV positivity slightly increased CIMT even after sensitivity analyses. Conclusions: HIV infection and PI exposure are not strong independent risk factors for subclinical atherosclerosis. Confounding may contribute to overestimation of the risk associated with HIV and PI exposure. C1 [Hulten, E.; Mitchell, J.; Scally, J.; Gibbs, B.; Villines, T. C.] Walter Reed Army Med Ctr, Dept Cardiol, Washington, DC 20307 USA. [Hulten, E.] Walter Reed Army Med Ctr, Dept Internal Med, Washington, DC 20307 USA. RP Hulten, E (reprint author), Walter Reed Army Med Ctr, Dept Cardiol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM edward.hulten@amedd.army.mil OI Hulten, Edward/0000-0001-9281-0032 NR 61 TC 55 Z9 56 U1 0 U2 1 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1355-6037 J9 HEART JI Heart PD NOV 15 PY 2009 VL 95 IS 22 BP 1826 EP 1835 DI 10.1136/hrt.2009.177774 PG 10 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 512OH UT WOS:000271259000053 PM 19632982 ER PT J AU Bedair, SS Fedder, GK AF Bedair, Sarah S. Fedder, Gary K. TI Picogram material dosing of microstructures SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID EVAPORATION; DIFFUSION; MENISCUS; SESSILE; DROPS; FLOW; AIR AB A solution delivery platform comprised of a suspended microcapillary connected to a microwell enables picogram solute deposition on suspended structures. Precision material placement in the capillary from a 100 pl drop inkjetted into the well is achieved without the destruction of the microstructure and adjacent submicron electrostatic gaps. This method scales to smaller structures without the need for drop miniaturization. The theory behind the solute transfer in the system is developed. Three regions in the drying process are observed and match with the model. The "accumulation" region builds solute concentration in the capillary. The "solidification" region initiates the solidification of solute starting at the free end of the capillary. The "termination" region is characterized by a rapid increase in the solidification due to an increase in the well concentration near the end of the drop lifetime. The accumulation time and solidification rate dependence on concentration compare well with the model. (C) 2009 American Institute of Physics. [doi: 10.1063/1.3248305] C1 [Bedair, Sarah S.] USA, Res Lab, Adelphi, MD 20783 USA. [Fedder, Gary K.] Carnegie Mellon Univ, Dept Elect & Comp Engn, Pittsburgh, PA 15213 USA. [Fedder, Gary K.] Carnegie Mellon Univ, Inst Robot, Pittsburgh, PA 15213 USA. RP Bedair, SS (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM sarahbedair@gmail.com RI Bedair, Sarah/D-9130-2013; Fedder, Gary/I-7081-2013 OI Fedder, Gary/0000-0002-2380-5210 FU National Institute for Occupational Safety and Health (NIOSH/CDC) [200-2002-00528]; Air Force Office of Sponsored Research [FA9550-07-1-0245] FX The authors thank Suresh Sathanam for post-CMOS MEMS processing, Lawrence Schultz for polymer preparation and jetting, and Shi-Chune Yao for technical interaction. This work is funded in part by the National Institute for Occupational Safety and Health (NIOSH/CDC) Award No. 200-2002-00528 and the Air Force Office of Sponsored Research Grant No. FA9550-07-1-0245. The findings and conclusions in this publication have not been formally disseminated by NIOSH or AFOSR and should not be construed to represent any agency determination or policy. NR 17 TC 6 Z9 6 U1 0 U2 4 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD NOV 15 PY 2009 VL 106 IS 10 AR 104913 DI 10.1063/1.3248305 PG 7 WC Physics, Applied SC Physics GA 534YB UT WOS:000272932300150 ER PT J AU Li, LL Victoria, J Kapoor, A Blinkova, O Wang, CL Babrzadeh, F Mason, CJ Pandey, P Triki, H Bahri, O Oderinde, BS Baba, MM Bukbuk, DN Besser, JM Bartkus, JM Delwart, EL AF Li, Linlin Victoria, Joseph Kapoor, Amit Blinkova, Olga Wang, Chunlin Babrzadeh, Farbod Mason, Carl J. Pandey, Prativa Triki, Hinda Bahri, Olfa Oderinde, Bamidele Soji Baba, Marycelin Mandu Bukbuk, David Nadeba Besser, John M. Bartkus, Joanne M. Delwart, Eric L. TI A Novel Picornavirus Associated with Gastroenteritis SO JOURNAL OF VIROLOGY LA English DT Article ID PROVENTRICULAR DILATATION DISEASE; POLYMERASE-CHAIN-REACTION; MERKEL CELL-CARCINOMA; SOUTH ASIAN CHILDREN; AICHI-VIRUS; COMPLETE GENOME; STOOL SAMPLES; IDENTIFICATION; POLYOMAVIRUS; INFECTIONS AB A novel picornavirus genome was sequenced, showing 42.6%, 35.2%, and 44.6% of deduced amino acid identities corresponding to the P1, P2, and P3 regions, respectively, of the Aichi virus. Divergent strains of this new virus, which we named salivirus, were detected in 18 stool samples from Nigeria, Tunisia, Nepal, and the United States. A statistical association was seen between virus shedding and unexplained cases of gastroenteritis in Nepal (P = 0.0056). Viruses with approximately 90% nucleotide similarity, named klassevirus, were also recently reported in three cases of unexplained diarrhea from the United States and Australia and in sewage from Spain, reflecting a global distribution and supporting a pathogenic role for this new group of picornaviruses. C1 [Li, Linlin; Victoria, Joseph; Kapoor, Amit; Blinkova, Olga; Delwart, Eric L.] Blood Syst Res Inst, San Francisco, CA 94118 USA. [Li, Linlin; Victoria, Joseph; Kapoor, Amit; Blinkova, Olga; Delwart, Eric L.] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA. [Wang, Chunlin; Babrzadeh, Farbod] Stanford Univ, Stanford Genome Technol Ctr, Stanford, CA 94305 USA. [Mason, Carl J.] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand. [Pandey, Prativa] CIWEC Clin Travel Med Ctr, Kathmandu, Nepal. [Triki, Hinda; Bahri, Olfa] Inst Pasteur, WHO Reg Reference Lab Poliomyelitis, Lab Clin Virol, Tunis, Tunisia. [Oderinde, Bamidele Soji; Baba, Marycelin Mandu; Bukbuk, David Nadeba] Univ Maiduguri, Teaching Hosp, WHO Natl Polio Lab, Maiduguri, Borno State, Nigeria. [Besser, John M.; Bartkus, Joanne M.] Minnesota Dept Hlth, Publ Hlth Lab Div, Mol Epidemiol Unit, St Paul, MN USA. RP Delwart, EL (reprint author), Blood Syst Res Inst, 270 Masonic Ave, San Francisco, CA 94118 USA. EM delwarte@medicine.ucsf.edu RI Li, Linlin/E-3335-2010; Valle, Ruben/A-7512-2013; OI Bukbuk, David Nadeba/0000-0003-3388-3842; Delwart, Eric/0000-0002-6296-4484; MASON, CARL/0000-0002-3676-2811 FU BSRI; NHLBI [R01HL083254] FX We thank Michael P. Busch and BSRI for sustained support and NHLBI for grant R01HL083254 to E. L. NR 53 TC 81 Z9 81 U1 1 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD NOV 15 PY 2009 VL 83 IS 22 BP 12002 EP 12006 DI 10.1128/JVI.01241-09 PG 5 WC Virology SC Virology GA 510JJ UT WOS:000271084100059 PM 19759142 ER PT J AU Tis, JE Helgeson, M Lehman, RA Dmitriev, AE AF Tis, John E. Helgeson, Melvin Lehman, Ronald A. Dmitriev, Anton E. TI A Biomechanical Comparison of Different Types of Lumbopelvic Fixation SO SPINE LA English DT Article DE biomechanics; pelvic fixation; long construct; pedicle screw ID L-ROD INSTRUMENTATION; GALVESTON TECHNIQUE; PELVIC FIXATION; SACROPELVIC FIXATION; LUMBOSACRAL FIXATION; TOTAL SACRECTOMY; LUQUE-GALVESTON; ILIAC SCREWS; NEUROMUSCULAR SCOLIOSIS; SPINAL INSTRUMENTATION AB Study Design. Comparative biomechanical testing in calf spines. Objective. To biomechanically evaluate 4 techniques of lumbosacral fixation. Summary of Background Data. Pelvic fixation is a problematic area, and currently, the preferred method of pelvic fixation is controversial. Clinically, iliac screws have demonstrated decreased rod breakage rates, and better correction of pelvic obliquity than unthreaded rods (Galveston technique), but several modern methods of iliac fixation have not been compared. Methods. A total of 32 male calf spines were tested under axial rotation, flexion/extension, and lateral bending. Following intact testing, specimens were instrumented in the following groups: group 1-Modified Galveston technique with rods connected directly to iliac screws (no S1 fixation); group 2-S1 screws and iliac screws with offset connectors distal to S1; group 3-S1 screws and iliac screws with offset connectors coupled to the longitudinal rod between L6 and S1; and group 4-S1 and S2 screws without iliac fixation. Pedicle screws were placed from L3 to L6. Following nondestructive testing, specimens were fixed at the cephalad aspect of the construct and flexed to failure, with peak failure moment (Nm). Results. Group 1 demonstrated significantly more flexion/extension than groups 2, 3, 4 (P < 0.001). There were no significant differences between groups for lateral bending or axial rotation at L3-S1 or L6-S1. During destructive testing, group 4 showed a significant reduction in peak failure compared to group 1 (P < 0.001), group 2 (P = 0.001), and group 3 (P < 0.001). There was no significant difference between groups 1, 2, and 3 and all specimens failed at the distal fixation. Conclusion. With extension of instrumentation across the lumbosacral junction, our results indicate significant improvement in stability with the use of S1 screws and iliac screw fixation. Furthermore, there does not appear to be any significant difference in the location of the connector for the iliac screw. C1 [Dmitriev, Anton E.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Spine Res Lab, Washington, DC 20307 USA. RP Tis, JE (reprint author), Dept Orthopaed & Rehabil, 601 N Caroline St,Suite 5245, Baltimore, MD 21287 USA. EM jtis1@aol.com FU DePuy Spine Inc. FX Supported by DePuy Spine Inc. NR 31 TC 17 Z9 19 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD NOV 15 PY 2009 VL 34 IS 24 BP E866 EP E872 PG 7 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 520YD UT WOS:000271884700017 PM 19910754 ER PT J AU Beck, EV Brozell, SR Blaudeau, JP Burggraf, LW Pitzer, RM AF Beck, Eric V. Brozell, Scott R. Blaudeau, Jean-Philippe Burggraf, Larry W. Pitzer, Russell M. TI Assessment of the Accuracy of Shape-Consistent Relativistic Effective Core Potentials Using Multireference Spin-Orbit Configuration Interaction Singles and Doubles Calculations of the Ground and Low-Lying Excited States of U4+ and U5+ SO JOURNAL OF PHYSICAL CHEMISTRY A LA English DT Article ID UNITARY-GROUP APPROACH; AB-INITIO; ELECTRONIC-STRUCTURE; BASIS-SETS; MOLECULAR CALCULATIONS; QUANTUM-CHEMISTRY; URANYL-ION; ACTINIDE COMPLEXES; PROGRAM SYSTEM; COMPOUNDS XUY AB Multireference spin-orbit configuration interaction calculations were used to determine the accuracy of 60-, 68, and 78-electron shape-consistent relativistic effective core potentials (RECPs) for uranium V and VI ground and low-lying excited states. Both 5f(n) and (5f6d)(n), (n = 1, 2) reference spaces were investigated using correlation-consistent double-zeta quality basis sets. Accuracy was assessed against gas-phase experimental spectra. The 68-electron RECP calculations yielded low relative and rms errors and predicted the empirical ordering of states most consistently. C1 [Brozell, Scott R.] Ohio Supercomp Ctr, Columbus, OH 43212 USA. [Beck, Eric V.] Lawrence Livermore Natl Lab, Livermore, CA 94551 USA. [Blaudeau, Jean-Philippe] USA, High Performance Technol Inc, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Burggraf, Larry W.] USAF, Dept Engn, Inst Technol, ENP, Wright Patterson AFB, OH 45433 USA. [Pitzer, Russell M.] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA. RP Brozell, SR (reprint author), Ohio Supercomp Ctr, 1224 Kinnear Rd, Columbus, OH 43212 USA. EM srb@osc.edu FU U.S. Department of Energy FX The authors thank Phil Christiansen for developing several RECPs. The views expressed in this article are those of the authors and do not reflect the official policy or position of the United State Air Force, Department of Defense or the U.S. Government. This work was made possible in par; through a grant by the U.S. Department of Energy Nuclear Engineering Education Reasearch (NEER) Program. Additional support was provided by Mr. James Grey and Mr. David Doaks at the Air Force Institute of Technology. Rajni Tyagi, with the Ohio State University Department of Chemistry, provided invaluable insights and assistance for this work. S.R.B. acknowledges the use of computional facilities at the Ohio Supercomputer Center and The Ohio State University. NR 72 TC 5 Z9 5 U1 0 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1089-5639 J9 J PHYS CHEM A JI J. Phys. Chem. A PD NOV 12 PY 2009 VL 113 IS 45 BP 12626 EP 12631 DI 10.1021/jp9049846 PG 6 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 514WX UT WOS:000271428100037 PM 19888778 ER PT J AU Fox, DM Lee, JS AF Fox, David M. Lee, Joon Sang TI Development and evaluation of a model for soil-air fluidized bed rheological behavior SO INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN FLUIDS LA English DT Article DE air-soil; rheology; blast; flow; particle properties; multi-component; ejecta; fluidized bed; CFD; mine blast; multi-phase ID RANGE SPHERICAL EXPLOSIONS; CFD MODELS AB The ground vehicle mine blast mitigation problem represents a research topic that has recently been generating a very high level of interest and activity. Many aspects of the physics of the problem have been extensively researched. One area that has been neglected, however, is that aspect of the blast threat that relates to the rheology and flow, subsequent to ignition of the explosive, of the relatively energetic mixture of air and soil, sometimes referred to as ejecta. Methods developed for the study of fluidized beds that are used in, e.g. the chemical and power generation process industries, were adapted in order to more clearly define the rheology of air-glass bead mixtures and also of air-soil mixtures that comprise the ejecta. Continuity and momentum balance equations developed for fluidized beds were adapted, using physical properties of glass beads and soils, into a form relates to the properties of mine blast ejecta. These equations were then discretized and solved, for a relatively simple geometry, in order to validate the model and gain a general sense of the flow behavior of particle-air blends. Parametric studies were performed to estimate the variation of the rheology of the air-particle mixtures as a function of the particle diameter and the sphericity of the particles. Finally, the flow properties of a couple of real soils were investigated via application of the two-phase flow model. Copyright (C) 2009 John Wiley & Sons, Ltd. C1 [Lee, Joon Sang] Wayne State Univ, Dept Mech Engn, Detroit, MI 48202 USA. [Lee, Joon Sang] Yonsei Univ, Dept Mech Engn, Seoul 120749, South Korea. [Fox, David M.] USA, RDECOM TARDEC, Warren, MI USA. RP Lee, JS (reprint author), Wayne State Univ, Dept Mech Engn, 5050 Anthony Wayne Dr 2100, Detroit, MI 48202 USA. EM joonlee@wayne.edu NR 24 TC 0 Z9 0 U1 1 U2 8 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 0271-2091 J9 INT J NUMER METH FL JI Int. J. Numer. Methods Fluids PD NOV 10 PY 2009 VL 61 IS 7 BP 810 EP 826 DI 10.1002/fld.1953 PG 17 WC Computer Science, Interdisciplinary Applications; Mathematics, Interdisciplinary Applications; Mechanics; Physics, Fluids & Plasmas SC Computer Science; Mathematics; Mechanics; Physics GA 513WF UT WOS:000271354100007 ER PT J AU He, HY Pandey, R Reveles, JU Khanna, SN Karna, SP AF He, Haiying Pandey, Ravindra Reveles, J. Ulises Khanna, Shiv N. Karna, Shashi P. TI Highly efficient (Cs8V) superatom-based spin-polarizer SO APPLIED PHYSICS LETTERS LA English DT Article ID BUILDING-BLOCKS; METAL-CLUSTERS AB Quantum transport through Molecules and the possibility to manipulate spin has generated tremendous excitement. Here, we demonstrate unusual spin transport through a molecule of two Cs8V magnetic superatoms. Calculations based oil density functional theory and nonequilibrium Green's function methods find a much higher current for the spin-down charge carriers relative to the spin-up carriers ill the model Au-(Cs8V)-(Cs8V)-Au device system with almost 100% spin polarization, indicating a highly efficient spin polarizer. The new behavior is rooted in strong coupling of the localized magnetic core on V and the Itinerant electrons of the Cs shell atoms leading to nearly full spin polarization. (C) 2009 American Institute of Physics. [doi:10.1063/1.3259646] C1 [He, Haiying; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [He, Haiying; Pandey, Ravindra] Michigan Technol Univ, Multiscale Technol Inst, Houghton, MI 49931 USA. [Reveles, J. Ulises; Khanna, Shiv N.] Virginia Commonwealth Univ, Dept Phys, Richmond, VA 23284 USA. [Karna, Shashi P.] USA, Res Lab, Weap & Mat Res Directorate, ATTN AMSRD ARL WM, Aberdeen Proving Ground, MD 21005 USA. RP Pandey, R (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. RI Reveles, J Ulises/B-2655-2009 FU U S. Department of the Army through a MURI [W911NF-06-1-0280] FX Helpful discussions with S Gowtham are acknowledged. The work at Virginia Commonwealth University was supported by the U S. Department of the Army through a MURI Grant No. W911NF-06-1-0280. NR 23 TC 14 Z9 14 U1 2 U2 9 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD NOV 9 PY 2009 VL 95 IS 19 AR 192104 DI 10.1063/1.3259646 PG 3 WC Physics, Applied SC Physics GA 532NR UT WOS:000272756600035 ER PT J AU Cohen, SP Nguyen, C Kapoor, SG Anderson-Barnes, VC Foster, L Shields, C McLean, B Wichman, T Plunkett, A AF Cohen, Steven P. Nguyen, Conner Kapoor, Shruti G. Anderson-Barnes, Victoria C. Foster, Leslie Shields, Cynthia McLean, Brian Wichman, Todd Plunkett, Anthony TI Back Pain During War An Analysis of Factors Affecting Outcome SO ARCHIVES OF INTERNAL MEDICINE LA English DT Article ID RISK-FACTORS; PREDICTIVE FACTORS; PROGNOSTIC-FACTORS; WORK DISABILITY; THE-LITERATURE; NECK PAIN; INJURY; RETURN; MANAGEMENT AB Background: Back pain is the leading cause of disability in the world, but it is even more common in soldiers deployed for combat operations. Aside from battle injuries and psychiatric conditions, spine pain and other musculoskeletal conditions are associated with the lowest return-to-unit rate among service members medically evacuated out of Operations Iraqi and Enduring Freedom. Methods: Demographic, military-specific, and outcome data were prospectively collected over a 2-week period at the Deployed Warrior Medical Management Center in Germany on 1410 consecutive soldiers medically evacuated out of theaters of combat operations for a primary diagnosis pertaining to back pain between 2004 and 2007. The 2-week period represents the maximal allowable time an evacuated soldier can spend in treatment before disposition (ie, return to theater or evacuate to United States) is rendered. Electronic medical records were then reviewed to examine the effect a host of demographic and clinical variables had on the categorical outcome measure, return to unit. Results: The overall return-to-unit rate was 13%. Factors associated with a positive outcome included female sex, deployment to Afghanistan, being an officer, and a history of back pain. Trends toward not returning to duty were found for navy and marine service members, coexisting psychiatric morbidity, and not being seen in a pain clinic. Conclusions: The likelihood of a service member medically evacuated out of theater with back pain returning to duty is low irrespective of any intervention(s) or characteristic(s). More research is needed to determine whether concomitant treatment of coexisting psychological factors and early treatment "in theater" can reduce attrition rates. C1 [Cohen, Steven P.; Kapoor, Shruti G.] Johns Hopkins Sch Med, Dept Anesthesiol, Baltimore, MD 21029 USA. [Cohen, Steven P.] Johns Hopkins Sch Med, Pain Management Div, Baltimore, MD 21029 USA. [Cohen, Steven P.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Anderson-Barnes, Victoria C.] Walter Reed Army Med Ctr, Dept Orthoped Surg & Rehabil, Washington, DC 20307 USA. [Foster, Leslie; Wichman, Todd] Walter Reed Army Med Ctr, Phys Med Serv, Dept Orthoped Surg, Washington, DC 20307 USA. [Plunkett, Anthony] Walter Reed Army Med Ctr, Anesthesia Serv, Dept Surg, Washington, DC 20307 USA. [Nguyen, Conner] Landstuhl Reg Med Ctr, Phys Med & Rehabil Serv, Landstuhl, Germany. [Shields, Cynthia] Uniformed Serv Univ Hlth Sci, Dept Anesthesiol, Bethesda, MD 20814 USA. [McLean, Brian] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. RP Cohen, SP (reprint author), Johns Hopkins Sch Med, Dept Anesthesiol, 550 N Broadway,Ste 301, Baltimore, MD 21029 USA. EM scohen40@jhmi.edu FU John P. Murtha Neuroscience and Pain Institute, Johnstown, Pennsylvania; US Army; Army Regional Anesthesia & Pain Medicine Initiative, Washington, DC FX This study was funded in part by a Congressional grant from the John P. Murtha Neuroscience and Pain Institute, Johnstown, Pennsylvania; the US Army; and the Army Regional Anesthesia & Pain Medicine Initiative, Washington, DC. NR 33 TC 22 Z9 23 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD NOV 9 PY 2009 VL 169 IS 20 BP 1916 EP 1923 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 516BX UT WOS:000271517800015 PM 19901146 ER PT J AU Southerland, R AF Southerland, Ryan TI PURPLE HEART SO NEW YORK TIMES BOOK REVIEW LA English DT Book Review C1 [Southerland, Ryan] Stanford Law Sch, Stanford, CA USA. [Southerland, Ryan] USA, Washington, DC 20310 USA. RP Southerland, R (reprint author), Stanford Law Sch, Stanford, CA USA. NR 1 TC 1 Z9 1 U1 0 U2 0 PU NEW YORK TIMES PI NEW YORK PA 620 8TH AVE, NEW YORK, NY 10018 USA SN 0028-7806 J9 NY TIMES BK REV JI N. Y. Times Book Rev. PD NOV 8 PY 2009 BP 16 EP 16 PG 1 WC Humanities, Multidisciplinary SC Arts & Humanities - Other Topics GA 515QN UT WOS:000271487600013 ER PT J AU Chen, Q Mogilevsky, G Wagner, GW Forstater, J Kleinhammes, A Wu, Y AF Chen, Qiang Mogilevsky, Gregory Wagner, George W. Forstater, Jacob Kleinhammes, Alfred Wu, Yue TI Active anatase (001)-like surface of hydrothermally synthesized titania nanotubes SO CHEMICAL PHYSICS LETTERS LA English DT Article ID DELAMINATED ANATASE; TIO2; NANOSHEETS; CHEMISTRY; TITANATES; DIOXIDE; NMR AB Using (31)P and (13)C NMR with DFT calculations we demonstrate the exposed surface of titania nanotubes (TiNTs) is a stable, unterminated anatase (0 0 1)-like surface and is catalytically active under ambient conditions. We find that methanol dissociatively adsorbs on the surface of TiNTs agreeing with the predicted activity of surface dissociation of organic molecules on the crystalline (0 0 1)-anatase surface. We further examined the catalytic activity of anatase power, TiNT, and nanosheets in catalytic hydrolysis of S-[2-(diisopropylamino)ethyl]-O-ethyl methylphosphonothioate (VX) via (31)P NMR and demonstrate that titanate-like nanosheets are inactive in the reaction owing to their hydroxylated (0 0 1) surface. (C) 2009 Elsevier B.V. All rights reserved. C1 [Chen, Qiang; Mogilevsky, Gregory; Forstater, Jacob; Kleinhammes, Alfred; Wu, Yue] Univ N Carolina, Dept Phys & Astron, Chapel Hill, NC 27599 USA. [Chen, Qiang; Mogilevsky, Gregory; Forstater, Jacob; Kleinhammes, Alfred; Wu, Yue] Univ N Carolina, Curriculum Appl & Mat Sci, Chapel Hill, NC 27599 USA. [Wagner, George W.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Wu, Y (reprint author), Univ N Carolina, Dept Phys & Astron, Chapel Hill, NC 27599 USA. EM yuewu@physics.unc.edu OI Forstater, Jacob/0000-0003-0268-1009 FU NSF [DMR 0906547]; ARO [DAAD19-03-1-0326] FX Sketch of methanol adsorption on TiNTs was generated with Materials Studio 4.3. This work was supported by NSF, Grant No. DMR 0906547 and ARO, Grant No. DAAD19-03-1-0326. NR 23 TC 4 Z9 4 U1 0 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD NOV 6 PY 2009 VL 482 IS 1-3 BP 134 EP 138 DI 10.1016/j.cplett.2009.10.003 PG 5 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 512QJ UT WOS:000271264600026 ER PT J AU Friedlander, AM Little, SF AF Friedlander, Arthur M. Little, Stephen F. TI Advances in the development of next-generation anthrax vaccines SO VACCINE LA English DT Review DE Anthrax; Vaccine; Immunity; AVA ID RECOMBINANT PROTECTIVE ANTIGEN; EQUINE ENCEPHALITIS-VIRUS; AEROSOL SPORE CHALLENGE; BACILLUS-ANTHRACIS; NASAL IMMUNIZATION; INHALATIONAL ANTHRAX; IMMUNE-RESPONSES; DNA VACCINATION; RHESUS MACAQUES; LETHAL TOXIN AB Anthrax, a disease of herbivores, only rarely infects humans. However, the threat of using Bacillus anthracis, the causative agent, to intentionally produce disease has been the impetus for development of next-generation vaccines. Two licensed vaccines have been available for human use for several decades. These are composed of acellular culture supernatants containing the protective antigen (PA) component of the anthrax toxins. In this review we summarize the various approaches used to develop improved vaccines. These efforts have included the use of PA with newer adjuvants and delivery systems, including bacterial and viral vectors and DNA vaccines. Attempts to broaden the protection afforded by PA-based vaccines have focused on adding other B. anthracis components, including spore and capsule antigens. Published by Elsevier Ltd. C1 [Friedlander, Arthur M.; Little, Stephen F.] USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. RP Friedlander, AM (reprint author), USA, Med Res Inst Infect Dis, Bacteriol Div, 1425 Porter St, Ft Detrick, MD 21702 USA. EM arthur.friedlander@us.army.mil NR 82 TC 42 Z9 42 U1 1 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD NOV 5 PY 2009 VL 27 BP D28 EP D32 DI 10.1016/j.vaccine.2009.08.102 PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 520UY UT WOS:000271876100006 PM 19837282 ER PT J AU Schmaljohn, C AF Schmaljohn, Connie TI Vaccines for hantaviruses SO VACCINE LA English DT Article DE Hantavirus; Hemorrhagic fever with renal syndrome; Hantavirus pulmonary syndrome ID KOREAN HEMORRHAGIC-FEVER; HANTAAN-VIRUS-VACCINE; PULMONARY SYNDROME; RENAL SYNDROME; PUUMALA HANTAVIRUS; UNITED-STATES; NEPHROPATHIA-EPIDEMICA; PROTECTS HAMSTERS; ETIOLOGIC AGENT; ANDES VIRUS AB Hantaviruses are assigned to categories A and C on the National Institute of Allergy and Infectious Diseases (NIAID) Priority Pathogens list and to category C on the Centers for Disease Control and Prevention (CDC) Emergency Preparedness and Response list of boterrorism agents/diseases. These rodent-borne viruses are members of the family Bunyaviridae and are transmitted to humans in aerosols of rodent excreta. There are more than 20 recognized hantaviruses, some of which are associated with one of two serious human diseases: hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS). Because of the global distribution of hantaviruses, the historical association of HFRS-causing viruses with military operations and the recent emergence of the HPS-causing viruses, efforts are continuing to develop safe and effective hantavirus vaccines. This review addresses the significance of hantaviruses as they relate to biodefense and provides information about conventional and molecular vaccines for HFRS that have advanced to clinical studies. Published by Elsevier Ltd. C1 USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Schmaljohn, C (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM connie.schmaljohn@amedd.army.mil FU Medical Infectious Diseases Research Program; Defense Threat Reduction Agency of the Medical Research Material Command; U.S. Army FX C.S. is funded by the Medical Infectious Diseases Research Program and the Defense Threat Reduction Agency of the Medical Research Material Command, U.S. Army. Opinions, interpretations, conclusions, and recommendations are the author's and are not necessarily endorsed by the U.S. Army or the Department of Defense. NR 46 TC 31 Z9 33 U1 0 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD NOV 5 PY 2009 VL 27 BP D61 EP D64 DI 10.1016/j.vaccine.2009.07.096 PG 4 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 520UY UT WOS:000271876100013 PM 19837289 ER PT J AU Smith, LA AF Smith, Leonard A. TI Botulism and vaccines for its prevention SO VACCINE LA English DT Review DE Botulism; Botulinum neurotoxin; Pentavalent botulinum toxoid; Recombinant subunit vaccine; Fragment C ID TOXIN FRAGMENT-C; NEUROTOXIN SEROTYPE-A; COMPLETE NUCLEOTIDE-SEQUENCE; HIGH-LEVEL EXPRESSION; AMINO-ACID-SEQUENCE; CLOSTRIDIUM-BOTULINUM; TETANUS TOXIN; ESCHERICHIA-COLI; PICHIA-PASTORIS; RECOMBINANT VACCINE AB Botulism is a severe neuroparalytic disease caused by toxins produced by several Clostridium species. Botulinum toxin has been of concern to the US military and its allies as a biowarfare weapon since World War II and, in more recent times, by the Centers for Disease Control and Prevention (CDC) as a potential bioterrorist threat to the public. The most effective means of defending against the toxin is by inducing a protective immune response through vaccination. Vaccination with an appropriate antigen will produce neutralizing antibodies that will bind to and clear toxin from the circulation before it can enter nerve cells and block neurotransmission. Immunity from botulism, however, has the disadvantage of precluding an individual from realizing the potential benefits of therapeutic botulinum toxin, if such a need were to arise. Botulinum toxin has been used in the treatment of numerous neuromuscular, autonomic, and sensory disorders since it was first approved for the management of strabismus and blepharospasm by the Food and Drug Administration (FDA) in 1989. Notwithstanding the value of the neurotoxin as a therapeutic drug, vaccines have been and will continue to be an important line of defense for those who work with the toxin (at-risk workers) and a select population of the military, law enforcement, and first responders. The first vaccine used to protect against botulinum neurotoxin was a chemically detoxified extract from Clostridium botulinum. A Pentavalent botulinum toxoid (PBT) vaccine in service today is administered under an Investigational New Drug (IND) application held by the CDC. Recombinant subunit vaccines are in development and a bivalent H-c vaccine (rBV A/B (Pichia pastoris)) is presently being evaluated in a phase II clinical trial. This review focuses on botulism and the development of vaccines for its prevention. Published by Elsevier Ltd C1 USA, Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP Smith, LA (reprint author), USA, Med Res & Mat Command, Ft Detrick, MD 21702 USA. EM Leonard.Smith@amedd.army.mil NR 138 TC 52 Z9 58 U1 0 U2 27 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD NOV 5 PY 2009 VL 27 SU 4 BP D33 EP D39 DI 10.1016/j.vaccine.2009.08.059 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 520UY UT WOS:000271876100007 PM 19837283 ER PT J AU Costanzo-Garvey, DL Pfluger, PT Dougherty, MK Stock, JL Boehm, M Chaika, O Fernandez, MR Fisher, K Kortum, RL Hong, EG Jun, JY Ko, HJ Schreiner, A Volle, DJ Treece, T Swift, AL Winer, M Chen, D Wu, M Leon, LR Shaw, AS McNeish, J Kim, JK Morrison, DK Tschop, MH Lewis, RE AF Costanzo-Garvey, Diane L. Pfluger, Paul T. Dougherty, Michele K. Stock, Jeffery L. Boehm, Matthew Chaika, Oleg Fernandez, Mario R. Fisher, Kurt Kortum, Robert L. Hong, Eun-Gyoung Jun, John Y. Ko, Hwi Jin Schreiner, Aimee Volle, Deanna J. Treece, Tina Swift, Amy L. Winer, Mike Chen, Denise Wu, Min Leon, Lisa R. Shaw, Andrey S. McNeish, John Kim, Jason K. Morrison, Deborah K. Tschoep, Matthias H. Lewis, Robert E. TI KSR2 Is an Essential Regulator of AMP Kinase, Energy Expenditure, and Insulin Sensitivity SO CELL METABOLISM LA English DT Article ID ACTIVATED PROTEIN-KINASE; GLUCOSE-TRANSPORT; CELLULAR-ENERGY; SKELETAL-MUSCLE; IN-VIVO; SCAFFOLD; PHOSPHORYLATION; OBESITY; IDENTIFICATION; SUPPRESSOR AB Kinase suppressors of Ras 1 and 2 (KSR1 and KSR2) function as molecular scaffolds to potently regulate the MAP kinases ERK1/2 and affect multiple cell fates. Here we show that KSR2 interacts with and modulates the activity of AMPK. KSR2 regulates AMPK-dependent glucose uptake and fatty acid oxidation in mouse embryonic fibroblasts and glycolysis in a neuronal cell line. Disruption of KSR2 in vivo impairs AMPK-regulated processes affecting fatty acid oxidation and thermogenesis to cause obesity. Despite their increased adiposity, ksr2(-/-) mice are hypophagic and hyperactive but expend less energy than wild-type mice. In addition, hyperinsulinemic-euglycemic clamp studies reveal that ksr2(-/-) mice are profoundly insulin resistant. The expression of genes mediating oxidative phosphorylation is also downregulated in the adipose tissue of ksr2(-/-) mice. These data demonstrate that ksr2(-/-) mice are highly efficient in conserving energy, revealing a novel role for KSR2 in AMPK-mediated regulation of energy metabolism. C1 [Costanzo-Garvey, Diane L.; Boehm, Matthew; Chaika, Oleg; Fernandez, Mario R.; Fisher, Kurt; Kortum, Robert L.; Schreiner, Aimee; Volle, Deanna J.; Treece, Tina; Lewis, Robert E.] Univ Nebraska Med Ctr, Eppley Inst Res Canc & Allied Dis, Omaha, NE 68198 USA. [Pfluger, Paul T.; Tschoep, Matthias H.] Univ Cincinnati, Dept Med, Obes Res Ctr, Cincinnati, OH 45237 USA. [Dougherty, Michele K.; Morrison, Deborah K.] NCI, Lab Cell & Dev Signaling, Ctr Canc Res, NIH, Frederick, MD 21702 USA. [Stock, Jeffery L.; McNeish, John] Pfizer Global Res & Dev, Genet Technol, Groton, CT 06340 USA. [Hong, Eun-Gyoung; Jun, John Y.; Ko, Hwi Jin; Kim, Jason K.] Penn State Coll Med, Penn State Mouse Metab Phenotyping Ctr, Dept Cellular & Mol Physiol, Hershey, PA 17033 USA. [Swift, Amy L.; Winer, Mike; Chen, Denise; Wu, Min] Seahorse Biosci, N Billerica, MA 01862 USA. [Leon, Lisa R.] USA, Thermal Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA. [Shaw, Andrey S.] Washington Univ, Sch Med, Howard Hughes Med Inst, St Louis, MO 63110 USA. [Shaw, Andrey S.] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA. RP Lewis, RE (reprint author), Univ Nebraska Med Ctr, Eppley Inst Res Canc & Allied Dis, Omaha, NE 68198 USA. EM rlewis@unmc.edu RI Pfluger, Paul/B-4889-2010; Tschoep, Matthias/I-5443-2014; OI Tschoep, Matthias/0000-0002-4744-371X FU National Institutes of Health (NIH) [DK52809, DK69987, DK59630, DK56863, P20 RR016469]; Nebraska Research Initiative; Skala Fellowship; University of Nebraska Medical Center (UNMC); American Diabetes Association FX We thank the members of the Lewis laboratory for comments and criticism. M. Birnbaum (University of Pennsylvania) is thanked for his gift of the constitutively active AMPK construct. This work was supported by National Institutes of Health (NIH) grants to R.E.L. (DK52809) and M.H.T. (DK69987, DK59630, and DK56863) and by support from the Nebraska Research Initiative (to R.E.L.). M.R.F was supported by the Skala Fellowship, and M.B. was supported by the Bukey Fellowship from the University of Nebraska Medical Center (UNMC). K.F. was supported by a Physician/Scientist Training Award from the American Diabetes Association. The UNMC Microarray Core Facility receives partial support from NIH grant P20 RR016469. For those studies conducted at United States Army Research Institute Environmental Medicine (USARIEM), the opinions or assertions contained herein are the private views of the author(s) and are not to be construed as official or reflecting the views of the Army or the Department of Defense. Any citations of commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement of approval of the products or services of these organizations. NR 43 TC 60 Z9 60 U1 0 U2 7 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 1550-4131 J9 CELL METAB JI Cell Metab. PD NOV 4 PY 2009 VL 10 IS 5 BP 366 EP 378 DI 10.1016/j.cmet.2009.09.010 PG 13 WC Cell Biology; Endocrinology & Metabolism SC Cell Biology; Endocrinology & Metabolism GA 515UP UT WOS:000271498700006 PM 19883615 ER PT J AU Alkhalil, A Strand, S Mucker, E Huggins, JW Jahrling, PB Ibrahim, SM AF Alkhalil, Abdulnaser Strand, Sarah Mucker, Eric Huggins, John W. Jahrling, Peter B. Ibrahim, Sofi M. TI Inhibition of Monkeypox virus replication by RNA interference SO VIROLOGY JOURNAL LA English DT Article ID DOUBLE-STRANDED-RNA; POXVIRUS INFECTIONS; CIDOFOVIR; GENE; DELIVERY; CELLS; SIRNAS; TRANSCRIPTION; POLYMERASE; DISEASE AB The Orthopoxvirus genus of Poxviridae family is comprised of several human pathogens, including cowpox (CPXV), Vaccinia (VACV), monkeypox (MPV) and Variola (VARV) viruses. Species of this virus genus cause human diseases with various severities and outcome ranging from mild conditions to death in fulminating cases. Currently, vaccination is the only protective measure against infection with these viruses and no licensed antiviral drug therapy is available. In this study, we investigated the potential of RNA interference pathway (RNAi) as a therapeutic approach for orthopox virus infections using MPV as a model. Based on genome-wide expression studies and bioinformatic analysis, we selected 12 viral genes and targeted them by small interference RNA (siRNA). Forty-eight siRNA constructs were developed and evaluated in vitro for their ability to inhibit viral replication. Two genes, each targeted with four different siRNA constructs in one pool, were limiting to viral replication. Seven siRNA constructs from these two pools, targeting either an essential gene for viral replication (A6R) or an important gene in viral entry (E8L), inhibited viral replication in cell culture by 65-95% with no apparent cytotoxicity. Further analysis with wild-type and recombinant MPV expressing green fluorescence protein demonstrated that one of these constructs, siA6-a, was the most potent and inhibited viral replication for up to 7 days at a concentration of 10 nM. These results emphasis the essential role of A6R gene in viral replication, and demonstrate the potential of RNAi as a therapeutic approach for developing oligonucleotide-based drug therapy for MPV and other orthopox viruses. C1 [Alkhalil, Abdulnaser; Strand, Sarah; Mucker, Eric; Huggins, John W.; Ibrahim, Sofi M.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Jahrling, Peter B.] NIAID, Emerging Viral Pathogens Sect, NIH, Bethesda, MD 20892 USA. RP Alkhalil, A (reprint author), USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM naser.alkhalil@amedd.army.mil; sarah.strand@amedd.army.mil; muckerEM@amedd.army.mil; hugginsJW@amedd.army.mil; peter.jahrling@amedd.army.mil; sofi.ibrahim@amedd.army.mil FU Defense Threat Reduction Agency [4.10022_07_RD_B] FX We thank Mohamed Ait Ichou, Jason Farlow, Lorraine Farinick, and Catherine Kenyon for thoughtful discussions, critical review, and assistance during manuscript preparation. The research described herein was supported by a grant from the Defense Threat Reduction Agency, Project number 4.10022_07_RD_B. NR 46 TC 13 Z9 13 U1 1 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-422X J9 VIROL J JI Virol. J. PD NOV 4 PY 2009 VL 6 AR 188 DI 10.1186/1743-422X-6-188 PG 10 WC Virology SC Virology GA 526OB UT WOS:000272299300003 PM 19889227 ER PT J AU Otto, TC Harsch, CK Yeung, DT Magliery, TJ Cerasoli, DM Lenz, DE AF Otto, Tamara C. Harsch, Christina K. Yeung, David T. Magliery, Thomas J. Cerasoli, Douglas M. Lenz, David E. TI Dramatic Differences in Organophosphorus Hydrolase Activity between Human and Chimeric Recombinant Mammalian Paraoxonase-1 Enzymes SO BIOCHEMISTRY LA English DT Article ID HUMAN SERUM PARAOXONASE; HUMAN BUTYRYLCHOLINESTERASE; CHOLESTEROL EFFLUX; PON1; SOMAN; STIMULATION; HYDROLYSIS; EVOLUTION; ESTERS; DYAD AB Human serum paraoxonase-1 (HuPON1) has the capacity to hydrolyze aryl esters, lactones, oxidized phospholipids, and organophosphorus (OP) compounds. HuPON1 and bacterially expressed chimeric recombinant PON1s (G2E6 and G3C9) differ by multiple amino acids, none of which are in the putative enzyme active site. To address the importance of these amino acid differences, the abilities of HuPON1, G2E6, G3C9, and several variants to hydrolyze phenyl acetate, paraoxon, and V-type OP nerve agents were examined. HuPON1 and G2E6 have a 10-fold greater catalytic efficiency toward phenyl acetate than G3C9. In contrast, bacterial PON1s are better able to promote hydrolysis of paraoxon, whereas HuPON1 is considerably better at catalyzing the hydrolysis of nerve agents VX and VR. These studies demonstrate that mutations distant from the active site of PON1 have large and unpredictable effects on the substrate specificities and possibly the hydrolytic mechanisms of HuPON1, G2E6, and G3C9. The replacement of residue H115 in the putative active site with tryptophan (H115W) has highly disparate effects on HuPON1 and G2E6. In HuPON1, variant H115W loses the ability to hydrolyze VR but has improved activity toward paraoxon and VX. The H115W variant of G2E6 has paraoxonase activity similar to that of wild-type G2E6, modest activity with phenyl acetate and VR, and enhanced VX hydrolysis. VR inhibits H115W HuPON1 competitively when paraoxon is the substrate and noncompetitively when VX is the Substrate. We have identified the first variant of HuPON1, H115W, that displays significantly enhanced catalytic activity against an authentic V-type nerve agent. C1 [Otto, Tamara C.; Yeung, David T.; Cerasoli, Douglas M.; Lenz, David E.] USA, Med Res Inst Chem Def, Physiol & Immunol Branch, Div Res, Aberdeen Proving Ground, MD 21010 USA. [Harsch, Christina K.; Magliery, Thomas J.] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA. [Magliery, Thomas J.] Ohio State Univ, Dept Biochem, Columbus, OH 43210 USA. RP Lenz, DE (reprint author), USA, Med Res Inst Chem Def, Physiol & Immunol Branch, Div Res, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM david.lenz@us.army.mil RI Magliery, Thomas/B-6050-2009; OI Magliery, Thomas/0000-0003-0779-1477; /0000-0001-5692-0170 FU NIH Counter ACT Center of Excellence [U54 NS058183]; Defense Threat Reduction Agency-Joint Science and Technology Office FX This work was supported by NIH Counter ACT Center of Excellence Grant U54 NS058183 [to D.E.L. (Center PI), D.M.C., and T.J.M.] and by the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S&T Division (to D.E.L.). NR 23 TC 29 Z9 33 U1 4 U2 14 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0006-2960 J9 BIOCHEMISTRY-US JI Biochemistry PD NOV 3 PY 2009 VL 48 IS 43 BP 10416 EP 10422 DI 10.1021/bi901161b PG 7 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 509NA UT WOS:000271023500024 PM 19764813 ER PT J AU Batchinsky, A Skinner, J Salinas, J Necsoiu, C Nguyen, R Walker, K Anchin, J Weiss, D Jones, J Holcomb, J Cancio, L AF Batchinsky, Andriy Skinner, James Salinas, Jose Necsoiu, Corina Nguyen, Ruth Walker, Kerfoot Anchin, Jerry Weiss, Daniel Jones, John Holcomb, John Cancio, Leopoldo TI Does Heart-Rate Complexity Analysis Work in the Real World? Changes in the Point Correlation Dimension of the Heart Rate During Prehospital Life-Saving Interventions SO CIRCULATION LA English DT Meeting Abstract CT 82nd Scientific Session of the American-Heart-Association CY NOV 14-18, 2009 CL Orlando, FL SP Amer Heart Assoc C1 [Batchinsky, Andriy; Salinas, Jose; Necsoiu, Corina; Nguyen, Ruth; Walker, Kerfoot; Cancio, Leopoldo] USA, Inst Surg Rsch, Ft Sam Houston, TX USA. [Skinner, James; Anchin, Jerry; Weiss, Daniel; Jones, John] Vicor Technol Inc, Boca Raton, FL USA. [Holcomb, John] Univ Texas Hlth Sci Cntr, Houston, TX USA. RI Necsoiu, Corina/A-6255-2013 NR 0 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 3 PY 2009 VL 120 IS 18 SU 2 BP S1441 EP S1442 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 520GV UT WOS:000271831505005 ER PT J AU Bsoul, AA Ji, SY Ward, K Ryan, K Rickard, C Convertino, V Najarian, K AF Bsoul, Abed Al Raoof Ji, Soo-Yeon Ward, Kevin Ryan, Kathy Rickard, Caroline Convertino, Victor Najarian, Kayvan TI Prediction of Severity of Blood Volume Loss Using ECG Features Based on P, QRS, and T Waves SO CIRCULATION LA English DT Meeting Abstract CT 82nd Scientific Session of the American-Heart-Association CY NOV 14-18, 2009 CL Orlando, FL SP Amer Heart Assoc C1 [Bsoul, Abed Al Raoof; Ji, Soo-Yeon; Ward, Kevin; Najarian, Kayvan] Virginia Commonwealth Univ, Reanimat Engn Shock Cntr, Richmond, VA USA. [Rickard, Caroline; Convertino, Victor] USA, Inst Surg Rsch, San Antonio, TX USA. RI Najarian, Kayvan/B-2303-2010 NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 3 PY 2009 VL 120 IS 18 SU 2 BP S1466 EP S1466 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 520GV UT WOS:000271831505111 ER PT J AU Ji, SY Bsoul, AAR Ward, K Ryan, K Rickard, C Convertino, V Najarian, K AF Ji, Soo-Yeon Bsoul, Abed Al Raoof Ward, Kevin Ryan, Kathy Rickard, Caroline Convertino, Victor Najarian, Kayvan TI Incorporating Physiological Signals to Blood Loss Prediction Based on Discrete Wavelet Transformation SO CIRCULATION LA English DT Meeting Abstract CT 82nd Scientific Session of the American-Heart-Association CY NOV 14-18, 2009 CL Orlando, FL SP Amer Heart Assoc C1 [Ji, Soo-Yeon; Bsoul, Abed Al Raoof; Ward, Kevin; Najarian, Kayvan] Virginia Commonwealth Univ, Reanimat Engn Shock Cntr, Richmond, VA USA. [Ryan, Kathy; Rickard, Caroline; Convertino, Victor] US Army Inst Surg Rsch, San Antonio, TX USA. RI Najarian, Kayvan/B-2303-2010 NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 3 PY 2009 VL 120 IS 18 SU 2 BP S1483 EP S1483 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 520GV UT WOS:000271831505189 ER PT J AU Ji, SY Ward, K Ryan, K Rickard, C Convertino, V Vyas, N Stivoric, J Najarian, K AF Ji, Soo-Yeon Ward, Kevin Ryan, Kathy Rickard, Caroline Convertino, Victor Vyas, Nisarg Stivoric, John Najarian, Kayvan TI Prediction of Hypovolemia Severity Using ECG Signal with Wavelet Transformation Analysis From a Mobile Armband SO CIRCULATION LA English DT Meeting Abstract CT 82nd Scientific Session of the American-Heart-Association CY NOV 14-18, 2009 CL Orlando, FL SP Amer Heart Assoc C1 [Ji, Soo-Yeon; Ward, Kevin; Najarian, Kayvan] Virginia Commonwealth Univ, Reanimat Engn Shock Cntr, Richmond, VA USA. [Ryan, Kathy; Rickard, Caroline; Convertino, Victor] USA, Inst Surg Rsch, San Antonio, TX USA. [Vyas, Nisarg; Stivoric, John] BodyMedia Adv Dev, Pittsburgh, PA USA. RI Najarian, Kayvan/B-2303-2010 NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 3 PY 2009 VL 120 IS 18 SU 2 BP S1441 EP S1441 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 520GV UT WOS:000271831505002 ER PT J AU Krajnik, SJ Biever, KA Fellows, JB Penny, MM Creamer, KM AF Krajnik, Sarah J. Biever, Kimberlie A. Fellows, Jennifer B. Penny, Marcellyne M. Creamer, Kevin M. TI Institutional Multi-disciplinary Efforts to Improve Resuscitation Processes Have Saved Lives SO CIRCULATION LA English DT Meeting Abstract CT 82nd Scientific Session of the American-Heart-Association CY NOV 14-18, 2009 CL Orlando, FL SP Amer Heart Assoc C1 [Krajnik, Sarah J.; Biever, Kimberlie A.; Fellows, Jennifer B.; Penny, Marcellyne M.; Creamer, Kevin M.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 3 PY 2009 VL 120 IS 18 SU 2 BP S1455 EP S1455 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 520GV UT WOS:000271831505065 ER PT J AU Ward, K Vyas, N Ji, SY Rickards, C Ryan, K Convertino, V Stivoric, J Jackson, R Najarian, K AF Ward, Kevin Vyas, Nisarg Ji, Soo-Yeon Rickards, Caroline Ryan, Kathy Convertino, Victor Stivoric, John Jackson, Rachel Najarian, Kayvan TI Use of Low Level Physiologic Signals and Machine Learning to Derive Important Hemodyamic Variables During Acute Volume Loss SO CIRCULATION LA English DT Meeting Abstract CT 82nd Scientific Session of the American-Heart-Association CY NOV 14-18, 2009 CL Orlando, FL SP Amer Heart Assoc C1 [Ward, Kevin; Ji, Soo-Yeon; Najarian, Kayvan] Virginia Commonwealth Univ, Reanimat Engn Shock Cntr, Richmond, VA USA. [Vyas, Nisarg; Stivoric, John; Jackson, Rachel] BodyMedia Adv Dev, Pittsburgh, PA USA. [Rickards, Caroline; Ryan, Kathy; Convertino, Victor] US Army Inst Surg Rsch, San Antonio, TX USA. RI Najarian, Kayvan/B-2303-2010 NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 3 PY 2009 VL 120 IS 18 SU 2 BP S1482 EP S1483 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 520GV UT WOS:000271831505185 ER PT J AU Sengupta, R Billiar, TR Atkins, JL Kagan, VE Stoyanovsky, DA AF Sengupta, Rajib Billiar, Timothy R. Atkins, James L. Kagan, Valerian E. Stoyanovsky, Detcho A. TI Nitric oxide and dihydrolipoic acid modulate the activity of caspase 3 in HepG2 cells SO FEBS LETTERS LA English DT Article DE Lipoic acid; Caspase; Nitric oxide; Dihydrolipoic; Denitrosation ID ALPHA-LIPOIC ACID; PROTEIN S-NITROSOTHIOLS; CATALYTIC-ACTIVITY; THIOREDOXIN REDUCTASE; RHEUMATOID-ARTHRITIS; HEALTHY-VOLUNTEERS; ENDOTHELIAL-CELLS; HEPATOMA-CELLS; NITROSYLATION; APOPTOSIS AB Herein, we report that dihydrolipoic acid and lipoic acid (LA) plus lipoamide dehydrogenase and NADH denitrosate S-nitrosocaspase 3 (CASP-SNO). In HepG2 cells, S-nitroso-L-cysteine ethyl ester (SNCEE) impeded the activity of caspase 3 (CASP-SH), while a subsequent incubation of the cells in SNCEE-free medium resulted in endogenous denitrosation and reactivation of CASP-SH. The latter process was inhibited in thioredoxin reductase-deficient HepG2 cells, in which, however, LA markedly reactivated CASP-SH. The data obtained are discussed with focus on low molecular mass dithiols that mimic the activity of thioredoxin in reactions of protein S-denitrosation. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved. C1 [Kagan, Valerian E.; Stoyanovsky, Detcho A.] Univ Pittsburgh, Dept Environm & Occupat Hlth, Pittsburgh, PA 15213 USA. [Kagan, Valerian E.; Stoyanovsky, Detcho A.] Univ Pittsburgh, Ctr Free Radical & Antioxidant Hlth, Pittsburgh, PA 15213 USA. [Sengupta, Rajib; Billiar, Timothy R.] Univ Pittsburgh, Dept Surg, Pittsburgh, PA 15213 USA. [Atkins, James L.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Stoyanovsky, DA (reprint author), Univ Pittsburgh, Dept Environm & Occupat Hlth, Pittsburgh, PA 15219 USA. EM das11@pitt.edu RI Atkins, James/B-3577-2011; OI Stoyanovsky, Detcho/0000-0001-5591-4780; Sengupta, Rajib/0000-0003-0331-805X FU NIH [GM044100]; Walter Reed Army Institute of Research [W81XWH-09-P-0631, W81XWH-06-1-0247]; Office of Naval Research [42237] FX Disclaimer: The views, opinions, and/or findings contained herein are those of the authors and should not be construed as an official position, policy, or decision of the Department of the Army, the Department of the Navy or the Department of Defense. This work was funded in part by a grant from the Office of Naval Research # 42237. NR 53 TC 13 Z9 13 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0014-5793 J9 FEBS LETT JI FEBS Lett. PD NOV 3 PY 2009 VL 583 IS 21 BP 3525 EP 3530 DI 10.1016/j.febslet.2009.10.016 PG 6 WC Biochemistry & Molecular Biology; Biophysics; Cell Biology SC Biochemistry & Molecular Biology; Biophysics; Cell Biology GA 512YE UT WOS:000271287600023 PM 19822150 ER PT J AU Zhang, CF Zhang, F Cheng, A Kimball, B Wang, AY Xu, J AF Zhang, Chunfeng Zhang, Fan Cheng, An Kimball, Brian Wang, Andrew Y. Xu, Jian TI Frequency upconverted lasing of nanocrystal quantum dots in microbeads SO APPLIED PHYSICS LETTERS LA English DT Article DE biexcitons; microcavities; micromechanical resonators; nanostructured materials; optical pumping; photoluminescence; radiative lifetimes; semiconductor quantum dots; silicon compounds; stimulated emission; time resolved spectra; two-photon processes; whispering gallery modes ID OPTICAL-GAIN; LASER; COMPOSITE; EMISSION AB Stable, frequency upconverted lasing of semiconductor nanocrystal quantum dots was demonstrated in silica microbeads under two-photon pumping conditions. Upon infrared excitation, the stimulated emission of the nanocrystal-doped microbeads exhibits sharp peaks at lambda similar to 610 nm with narrow line widths of < 1 nm. The lasing action has been attributed to the biexciton gain coupled to the whispering gallery modes in spherical cavities, as confirmed by time-resolved photoluminescence spectra. The lasing lifetime characterized in term of pulse numbers (similar to 10(6) pulses) was two orders of magnitude longer than that of the dye salt-based two-photon lasers. C1 [Zhang, Chunfeng; Zhang, Fan; Cheng, An; Xu, Jian] Penn State Univ, Dept Engn Sci & Mech, State Coll, PA 16802 USA. [Kimball, Brian] USA, Nanomat Sci Team, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. [Wang, Andrew Y.] Ocean NanoTech LLC, Fayetteville, AR 72701 USA. RP Zhang, CF (reprint author), Penn State Univ, Dept Engn Sci & Mech, State Coll, PA 16802 USA. EM jianxu@engr.psu.edu RI Zhang, Fan/G-5220-2012; Zhang, Chunfeng/D-4732-2013 OI Zhang, Chunfeng/0000-0001-9030-5606 FU National Science Foundation [ECCS-0824186, ECCS-0846818, 0638209]; Army Research Office [DAAD19-02-D-0001, DURIP 2008-02136] FX The work at the Penn State University is being supported by the National Science Foundation under Grants ECCS-0824186 and ECCS-0846818 and Army Research Office under Grant Nos. DAAD19-02-D-0001 and DURIP 2008-02136, and that at Ocean NanoTech LLC. is supported by the National Science Foundation under Grant No. 0638209. NR 22 TC 13 Z9 13 U1 2 U2 17 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD NOV 2 PY 2009 VL 95 IS 18 AR 183109 DI 10.1063/1.3242352 PG 3 WC Physics, Applied SC Physics GA 518CD UT WOS:000271666800066 ER PT J AU Ye, XY Johann, DJ Hakami, RM Xiao, Z Meng, ZJ Ulrich, RG Issaq, HJ Veenstra, TD Blonder, J AF Ye, Xiaoying Johann, Donald J. Hakami, Ramin M. Xiao, Zhen Meng, Zhaojing Ulrich, Robert G. Issaq, Haleem J. Veenstra, Timothy D. Blonder, Josip TI Optimization of protein solubilization for the analysis of the CD14 human monocyte membrane proteome using LC-MS/MS SO JOURNAL OF PROTEOMICS LA English DT Article DE CD14 monocyte; Membrane proteins; Solubilization; Methanol; Detergents; LC-MS/MS ID SPECTROMETRY-COMPATIBLE SURFACTANTS; TANDEM MASS-SPECTROMETRY; ENZYMATIC DIGESTION; CLEAVABLE DETERGENTS; RAT-LIVER; BACTERIORHODOPSIN; IDENTIFICATION; CELLS; EXPRESSION; METHANOL AB Proteomic profiling of membrane proteins is of vital importance in the search for disease biomarkers and drug development. However, the slow pace in this field has resulted mainly from the difficulty to analyze membrane proteins by mass spectrometry (MS). The objective of this investigation was to explore and optimize solubilization. of membrane proteins for shotgun membrane proteomics of the CD14 human monocytes by examining different systems that rely on: i) an organic solvent (methanol) ii) an acid-labile detergent 3-[3-(1,1-bisalkyloxyethyl)pyridin-1-yl) propane-1-sulfonate (PPS), iii) a combination of both agents (methanol+PPS). Solubilization efficiency of different buffers was first compared using bacteriorhodopsin as a model membrane protein. Selected approaches were then applied on a membrane subproteome isolated from a highly enriched human monocyte population that was similar to 98% positive for CD14 expression as determined by FACS analysis. A methanol-based buffer yielded 194 proteins of which 93 (48%) were mapped as integral membrane proteins. The combination of methanol and acid-cleavable detergent gave similar results; 203 identified proteins of which 93 (46%) were mapped integral membrane proteins. However, employing PPS 216 proteins were identified of which 75 (35%) were mapped as integral membrane proteins. These results indicate that methanol alone or in combination with PPS yielded significantly higher membrane protein identification/enrichment than the PPS alone. (C) 2009 Elsevier B.V. All rights reserved. C1 [Ye, Xiaoying; Xiao, Zhen; Meng, Zhaojing; Issaq, Haleem J.; Veenstra, Timothy D.; Blonder, Josip] NCI, Lab Prote & Analyt Technol, Adv Technol Program, SAIC Frederick Inc, Frederick, MD 21702 USA. [Johann, Donald J.] NCI, Ctr Canc Res, Bethesda, MD 20892 USA. [Hakami, Ramin M.] Oak Ridge Associated Univ, Fac Res Program, Belcamp, MD 21017 USA. [Ulrich, Robert G.] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Blonder, J (reprint author), NCI, Lab Prote & Analyt Technol, Adv Technol Program, SAIC Frederick Inc, Frederick, MD 21702 USA. EM blonder@ncifcrf.gov FU National Cancer Institute; National Institutes of Health [N01-CO-12400] FX This project has been funded in whole or in part with Federal funds from the National Cancer Institute, National Institutes of Health, under Contract N01-CO-12400. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organization imply endorsement by the United States Government. NR 62 TC 16 Z9 18 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1874-3919 J9 J PROTEOMICS JI J. Proteomics PD NOV 2 PY 2009 VL 73 IS 1 BP 112 EP 122 DI 10.1016/j.jprot.2009.08.008 PG 11 WC Biochemical Research Methods SC Biochemistry & Molecular Biology GA 522GL UT WOS:000271985800010 PM 19709643 ER PT J AU Kalman, DP Merrill, RL Wagner, NJ Wetzel, ED AF Kalman, Dennis P. Merrill, Richard L. Wagner, Norman J. Wetzel, Eric D. TI Effect of Particle Hardness on the Penetration Behavior of Fabrics Intercalated with Dry Particles and Concentrated Particle-Fluid Suspensions SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE Kevlar; ballistic; shear-thickening; spike puncture; yarn pull-out; nanoparticles ID BALLISTIC IMPACT ENERGY; SHEAR THICKENING FLUID; YARN PULL-OUT; FRICTION; ARMOR; DISPERSIONS; MECHANISM AB The penetration behavior of Kevlar fabric intercalated with dry particles and shear thickening fluids (STF), highly concentrated fluid-particle suspensions, is presented. In particular, the role of particle hardness is explored by comparing fabric treatments containing SiO(2) particles, which are significantly harder than Kevlar, to treatments containing softer poly(methyl methacrylate) (PMMA) particles. The fabric testing includes yarn pull-out, quasi-static spike puncture, and ballistic penetration resistance, performed on single fabric layers. It was found that both dry particle and STF treatments resulted in improvements in fabric properties relative to neat or poly(ethylene glycol) (PEG) treated fabrics. On comparison of treatments with different particle hardness, the SiO(2) materials performed better in all tests than comparable PMMA materials, although the SiO(2) treatments caused yarn failure in pull-out testing, reducing the total pull-out energy. In addition, resistance to yarn pull-out was found to be substantially higher for STF-treated fabrics than for dry particle treated fabrics. However, both dry particle addition and STF treatments exhibited comparable enhancements in puncture and ballistic resistance. These observations suggest that viscous stress transfer, friction, and physical entrainment of hard particles into filaments contribute to the demonstrated improvements in the properties of protective fabrics created with shear thickening fluids. C1 [Kalman, Dennis P.; Wagner, Norman J.] Univ Delaware, Dept Chem Engn, Newark, DE 19716 USA. [Merrill, Richard L.; Wetzel, Eric D.] USA, Res Lab, Div Mat, Aberdeen Proving Ground, MD 21005 USA. [Kalman, Dennis P.; Wagner, Norman J.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. RP Wetzel, ED (reprint author), Univ Delaware, Dept Chem Engn, Newark, DE 19716 USA. EM ewetzel@arl.army.mil RI Wagner, Norman/B-6558-2012 OI Wagner, Norman/0000-0001-9565-619X FU U.S. Army Research Office; U.S. Army Research laboratory [W91 1NF-05-2-0006] FX Research was sponsored by the U.S. Army Research Office and U.S. Army Research laboratory and was accomplished under Cooperative Agreement Number W91 1NF-05-2-0006. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Office, Army Research Laboratory, or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes, notwithstanding any copyright notation hereon. We also thank Joe Houghton for earlier work on this project. NR 32 TC 64 Z9 65 U1 4 U2 53 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD NOV PY 2009 VL 1 IS 11 BP 2602 EP 2612 DI 10.1021/am900516w PG 11 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA 522ZR UT WOS:000272039700026 PM 20356133 ER PT J AU Pati, RK Lee, IC Hou, SC Akhuemonkhan, O Gaskell, KJ Wang, Q Frenkel, AI Chu, D Salamanca-Riba, LG Ehrman, SH AF Pati, Ranjan K. Lee, Ivan C. Hou, Sicong Akhuemonkhan, Osifo Gaskell, Karen J. Wang, Qi Frenkel, Anatoly I. Chu, Deryn Salamanca-Riba, Lourdes G. Ehrman, Sheryl H. TI Flame Synthesis of Nanosized Cu-Ce-O, Ni-Ce-O, and Fe-Ce-O Catalysts for the Water-Gas Shift (WGS) Reaction SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE WGS catalysts; nanoparticles; flame synthesis; transmission electron microscopy; X-ray photoelectron spectroscopy ID RAY PHOTOELECTRON-SPECTROSCOPY; TEMPERATURE CO OXIDATION; CERIUM OXIDE; IN-SITU; CUO/CEO2 CATALYSTS; CU-CEO2 CATALYSTS; VACANCY FORMATION; SINGLE-CRYSTAL; SURFACE-AREA; NANOPARTICLES AB A flame synthesis method has been used to prepare nanosized, high-surface-area Cu-Ce-O, Ni-Ce-O, and Fe-Ce-O catalysts from aqueous solutions of metal acetate precursors. The particles were formed by vaporization of the precursors followed by reaction and then gas to particle conversion. The specific surface areas of the synthesized powders ranged from 127 to 163 m(2)/g. High-resolution transmission electron microscope Imaging showed that the particle diameters for the ceria materials are in the range of 3-10 nm, and a thin layer of amorphous material was observed on the surface of the particles. The presence and surface enrichment of the transition-metal oxides (CuO, NiO, and Fe(2)O(3)) on the ceria particles were detected using X-ray photoelectron spectroscopy. Electron energy-loss spectroscopic studies suggest the formation of a core-shell structure in the as-prepared particles. Extended X-ray absorption fine structure studies suggest that the dopants in all M-Ce-O systems are almost isostructural with their oxide counterparts, indicating the doping materials form separate oxide phases (CuO, Fe(2)O(3), NiO) within the host matrix (CeO(2)). Etching results confirm that most of the transition-metal oxides are present on the surface of CeO(2), easily dissolved by nitric acid. The performance of the flame-synthesized catalysts was examined toward water-gas shift (WGS) activity for fuel processing applications. The WGS activity of metal ceria catalysts decreases in the order Cu-Ce-O > Ni-Ce-O > Fe-Ce-O > CeO(2) with a feed mixture having a hydrogen to carbon monoxide (H(2)/CO) ratio of 1. There was no methane formation for these catalysts under the tested conditions. C1 [Ehrman, Sheryl H.] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. US Army, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA. Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA. Yeshiva Univ, Dept Phys, New York, NY 10016 USA. RP Ehrman, SH (reprint author), Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. EM sehrman@umd.edu RI Frenkel, Anatoly/D-3311-2011; Lee, Ivan/H-6444-2011; Wang, Qi/C-5478-2012; Salamanca-Riba, Lourdes/B-3785-2009; Gaskell, Karen/H-8270-2014 OI Frenkel, Anatoly/0000-0002-5451-1207; Salamanca-Riba, Lourdes/0000-0001-8155-6403; FU National Science Foundation [DMR-0080008]; US Army Research Laboratory [W911QX-04-C-0105]; Department of Energy, Basic Energy Sciences [DE-FG02-03ER15476]; U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-98CH10886, DE-FG02-05ER15688]; National Science Foundation FX We thank Amy Wingfield, Jason Repac, and Radhika Char for help in synthesizing the particles. Support from the National Science Foundation under Grant No. DMR-0080008 for the purchase of the X-ray photoelectron spectrometer is acknowledged. This work was partially supported by the US Army Research Laboratory, Contract No. W911QX-04-C-0105. R.K.P. and S.H.E. thank the U.S. Army Research Laboratory for instrument usage. A.I.F. and Q. W. gratefully acknowledge the support of this work by the Department of Energy, Basic Energy Sciences, under Grant No. DE-FG02-03ER15476. Use of the NSLS was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-98CH10886. Beamline X18B at the NSLS is supported in part by the Synchrotron Catalysis Consortium, U.S. Department of Energy Grant No. DE-FG02-05ER15688. Support of the Maryland NanoCenter and its NispLab is also acknowledged. The NispLab is supported in part by the National Science Foundation as an MRSEC Shared Experimental Facility. NR 64 TC 20 Z9 20 U1 4 U2 65 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD NOV PY 2009 VL 1 IS 11 BP 2624 EP 2635 DI 10.1021/am900533p PG 12 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA 522ZR UT WOS:000272039700029 PM 20356136 ER PT J AU Gaunaurd, GC Nguyen, LH AF Gaunaurd, G. C. Nguyen, L. H. TI Acoustic Energy Radiation from Rectilinearly Moving Point Sources with Unsteady Accelerations and Source-Strengths SO ACTA ACUSTICA UNITED WITH ACUSTICA LA English DT Article ID CLASSICAL ELECTRODYNAMICS; SOUND RADIATION AB A detailed analysis is shown of the acoustic energy and power outputs of a point (monopole) source continuously moving along a forward path in several cases. These pertain to sources that have unsteady speeds or source strengths / lifetimes governed by various specific laws. These could be trigonometric, exponential, hyperbolic-tangent, error-function or combinations of these. The angular, frequency and joint angular and frequency distributions of the radiated power and / or energy, as well as the total radiated energy, are analytically determined in all cases by spatial, temporal or spectral techniques, thus illustrating their use and derivations. Comparisons are made of the various outputs in the analyzed cases, which sometimes maybe realizable in practice and resemble analogous results in classical electrodynamics. C1 [Gaunaurd, G. C.; Nguyen, L. H.] Army Res Lab, Adelphi, MD 20783 USA. RP Gaunaurd, GC (reprint author), Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM electron20@aol.com NR 12 TC 1 Z9 1 U1 0 U2 1 PU S HIRZEL VERLAG PI STUTTGART PA POSTFACH 10 10 61, D-70 009 STUTTGART, GERMANY SN 1610-1928 J9 ACTA ACUST UNITED AC JI Acta Acust. United Acust. PD NOV-DEC PY 2009 VL 95 IS 6 BP 975 EP 983 DI 10.3813/AAA.918229 PG 9 WC Acoustics SC Acoustics GA 535MV UT WOS:000272974200002 ER PT J AU Arroyo, MA Sateren, WB Foglia, G Kibaya, R Langat, L Wasunna, M Bautista, CT Scott, PT Shaffer, DN Robb, ML Michael, NL Birx, DL McCutchan, FE AF Arroyo, Miguel A. Sateren, Warren B. Foglia, Ginamarie Kibaya, Rukia Langat, Lilian Wasunna, Monique Bautista, Christian T. Scott, Paul T. Shaffer, Douglas N. Robb, Merlin L. Michael, Nelson L. Birx, Deborah L. McCutchan, Francine E. TI Short Communication: HIV Type 1 Genetic Diversity among Tea Plantation Workers in Kericho, Kenya SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; MBEYA REGION; DUAL INFECTIONS; IN-DEPTH; TANZANIA; SUPERINFECTION; RECOMBINANTS; PREVALENCE; SUBTYPES; RISK AB In preparation for HIV-1 vaccine trials in Kenya, 2801 study volunteers, from a tea plantation in Kericho, were recruited as part of a prospective vaccine cohort development study. Cryopreserved plasma was available from 401 HIV-positive volunteers, and was the source of viral RNA for genotyping by the multiregion hybridization assay (MHA). Logistic regression was performed to determine association of risk factors and HIV-1 recombinant and dual infections. At baseline, HIV-1 subtype A was the dominant circulating pure subtype (56%), followed by subtype D (10%) and C (5%). Recombinant HIV-1 strains accounted for almost one-third of all infections (29%), with 7% infected with a dual strain of the HIV-1 variants described. A higher number of HIV-1 recombinant and dual infections was observed among volunteers who were 18-24 and 25-29 years of age, affiliated with the Luo tribe, had been married two or more times, reported not being circumcised, and had STI symptoms in the past 6 months. Adjusted odds ratios (AOR) significantly associated with HIV-1 recombinant and dual infection were age difference from current spouse (5-9 years; AOR = 2.5, 95% CI = 1.2-5.3 and >= 10 years; AOR = 3.1, 95% CI = 1.56.4) and reported STI symptoms in the past 6 months (AOR = 4.8, 95% CI = 2.0-11.6), respectively. In conclusion, our results suggest that there is considerable heterogeneity with respect to HIV-1 subtype diversity in this population that should be considered in the planning for future vaccine trials in the region. C1 [Arroyo, Miguel A.; Sateren, Warren B.; Michael, Nelson L.; Birx, Deborah L.; McCutchan, Francine E.] Walter Reed Army Inst Res, Div Retrovirol, US Mil HIV Res Program, Rockville, MD 20850 USA. [Sateren, Warren B.; Shaffer, Douglas N.] USA, Med Res Unit Kenya, Nairobi, Kenya. [Kibaya, Rukia; Langat, Lilian; Wasunna, Monique] Kenya Govt Med Res Ctr, Nairobi, Kenya. [Bautista, Christian T.; Scott, Paul T.; Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Rockville, MD 20850 USA. [Birx, Deborah L.] Bill & Melinda Gates Fdn, Seattle, WA 98102 USA. RP Arroyo, MA (reprint author), USAMC AFRIMS, Dept Retrovirol, APO, AP 96546 USA. EM miguel.a.arroyo@us.army.mil RI Bautista, Christian/B-2812-2011; OI Arroyo, Miguel/0000-0001-7416-8867 FU Walter Reed Army Institute of Research (WRAIR) [855, RV142]; Kenya Medical Research Institute, Nairobi, Kenya FX This study was supported and approved by the U.S. Military HIV Research Program at the Walter Reed Army Institute of Research (WRAIR protocol #855, RV142) and by the Kenya Medical Research Institute, Nairobi, Kenya. The material has been reviewed by the Walter Reed Army Institute of Research and there is no objection to its presentation and/or publication. The authors would like to thank the management and employees of James K. Finlay LLC (formerly African Highlands Produce) for their invaluable assistance and cooperation during the conduct of this research among plantation employees and their dependants. NR 13 TC 6 Z9 6 U1 0 U2 2 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV PY 2009 VL 25 IS 11 BP 1061 EP 1064 DI 10.1089/aid.2009.0092 PG 4 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 524ZF UT WOS:000272182200002 PM 19943788 ER PT J AU De Lorenzo, RA AF De Lorenzo, Robert A. TI ED use of military beneficiaries SO AMERICAN JOURNAL OF EMERGENCY MEDICINE LA English DT Article; Proceedings Paper CT Annual Meeting of the Society-for-Academic-Emergency-Medicine (SAEM) CY JUN 02, 2008 CL Washington, DC SP Soc Acad Emergency Med ID EMERGENCY-DEPARTMENT; CARE AB Context: The United States and Canada have ED use rates of approximately 40 visits per 100 population. Although the military network of hospitals shares many features with the civilian sector, this "system within a system" has universal health insurance coverage and provides an opportunity for comparison. Objective: The purpose of the study was to describe the emergency department (ED) use rate of a population of fully insured military health care beneficiaries. Design: A nonconcurrent database analysis of billing and visit data was performed to establish the ED use rate of military beneficiaries. Setting: The study operated within a global military health care system. Patients: The study involved military beneficiaries presenting to military and civilian EDs. Main Outcomes: The number of ED visits, demographics, and final diagnostic categories were analyzed. Descriptive methods were used to report data from fiscal years 2002 to 2007. Results: The military beneficiary Population averaged 9.1 million persons during 2002 to 2007, and the corresponding ED use rate was 40.0 visits per 100 beneficiaries. There was an upward trend with the rate peaking in 2007 at 47.0. The number of military EDs declined from 76 in 2002 to 53 in 2007, whereas the average annual ED volume increased. The 95% confidence intervals are within 0.02% for all reported values. Conclusion: The ED use rate was 40 visits per 100 military health care beneficiaries from 2002 to 2007. This is very similar to rates reported for US and Canadian populations. Near universal insurance coverage does not necessarily result in reduced ED use. Military EDs share the civilian sector challenges posed by steadily rising patient volumes. Published by Elsevier Inc. C1 [De Lorenzo, Robert A.] Brooke Army Med Ctr, MCHE CI, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. [De Lorenzo, Robert A.] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA. RP De Lorenzo, RA (reprint author), Brooke Army Med Ctr, MCHE CI, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. EM robert.delorenzo@amedd.army.mil NR 12 TC 1 Z9 1 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0735-6757 J9 AM J EMERG MED JI Am. J. Emerg. Med. PD NOV PY 2009 VL 27 IS 9 BP 1104 EP 1108 DI 10.1016/j.ajem.2008.08.012 PG 5 WC Emergency Medicine SC Emergency Medicine GA 527XB UT WOS:000272403400013 PM 19931758 ER PT J AU Acosta, RD Cash, BD AF Acosta, Ruben D. Cash, Brooks D. TI Clinical Effects of Colonic Cleansing for General Health Promotion: A Systematic Review SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Review ID COFFEE ENEMAS; IRRIGATION; AUTOINTOXICATION; CONSTIPATION AB The practice of colonic cleansing to promote general health and well-being continues to generate interest among the lay population. These practices are widely touted as adjuncts to improve vitality and as therapeutic modalities to minimize the symptoms, or prevent the actual development, of a variety of chronic disease states. The data supporting colonic cleansing and body "detoxification" have not been studied well in a systematic manner. This report describes a systematic review of the published literature of both the traditional and complementary and alternative medicine arenas that was performed in an attempt to qualify and quantify the value of colonic cleansing. The investigators concluded that there are no methodologically rigorous controlled trials of colonic cleansing to support the practice for general health promotion. Conversely, there are multiple case reports and case series that describe the adverse effects of colonic cleansing. The practice of colonic cleansing to improve or promote general health is not supported in the published literature and cannot be recommended at this time. C1 [Cash, Brooks D.] USN, Med Ctr, Div Gastroenterol, Walter Reed Army Med Ctr, Bethesda, MD 20889 USA. RP Cash, BD (reprint author), USN, Med Ctr, Div Gastroenterol, Walter Reed Army Med Ctr, 8901 Wisconsin Ave,Bldg 9, Bethesda, MD 20889 USA. EM brooks.cash@med.navy.mil NR 31 TC 11 Z9 11 U1 1 U2 12 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD NOV PY 2009 VL 104 IS 11 BP 2830 EP 2836 DI 10.1038/ajg.2009.494 PG 7 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 519YC UT WOS:000271805100028 PM 19724266 ER PT J AU Sawyer, T Stacey, M Mulreany, M Thompson, M Nitschke, Y Rutsch, F Mahnke, CB AF Sawyer, Taylor Stacey, Michelle Mulreany, Michael Thompson, Mark Nitschke, Yvonne Rutsch, Frank Mahnke, C. Becket TI Generalized Arterial Calcification of Infancy Associated with Meconium Peritonitis: A Case Report and Review of the Literature SO AMERICAN JOURNAL OF PERINATOLOGY LA English DT Review DE Generalized arterial calcification of infancy; idiopathic infantile arterial calcification; meconium peritonitis; ENPP1 gene ID PYROPHOSPHATE DEFICIENCY; DIAGNOSIS; SURVIVAL; SIBLINGS; THERAPY; PC-1 AB Generalized arterial calcification of infancy (GACI) is a rare genetic disorder consisting of diffuse arterial calcification and intimal proliferation. The disease typically results in progressive arterial stenosis and frequently leads to death from myocardial ischemia by 6 months of life. Affected infants are usually diagnosed before birth or in the neonatal period with symptoms of congestive heart failure. Therapy with bisphosphonate has been used to treat the condition, but with inconsistent results. The disease is associated with mutations in ENPP1 in the majority of the cases. Here we report a unique case of GACI associated with in utero meconium peritonitis and without coding region mutations of the ENPP1 gene. GACI should be considered in the differential diagnosis in infants presenting with arterial calcifications and congenital anomalies of the gastrointestinal tract. C1 [Sawyer, Taylor] Tripler Army Med Ctr, Dept Pediat, MCHK PE, Honolulu, HI 96859 USA. [Nitschke, Yvonne; Rutsch, Frank] Muenster Univ Childrens Hosp, Dept Gen Pediat, Munster, Germany. RP Sawyer, T (reprint author), Tripler Army Med Ctr, Dept Pediat, MCHK PE, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM taylor.1.sawyer@us.army.mil FU Deutsche Forschungsgemeinschaft [SFB 492]; Muenster Interdisciplinary Center for Clinical Research FX Y.N. and F.R. were supported by a grant from the Deutsche Forschungsgemeinschaft (SFB 492); F.R. was supported by a grant from Muenster Interdisciplinary Center for Clinical Research. NR 28 TC 6 Z9 7 U1 0 U2 0 PU THIEME MEDICAL PUBL INC PI NEW YORK PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA SN 0735-1631 J9 AM J PERINAT JI Am. J. Perinatol. PD NOV PY 2009 VL 26 IS 10 BP 711 EP 716 DI 10.1055/s-0029-1223282 PG 6 WC Obstetrics & Gynecology; Pediatrics SC Obstetrics & Gynecology; Pediatrics GA 507VN UT WOS:000270883400004 PM 19452427 ER PT J AU Summers, RM Swift, JA Dwyer, AJ Choi, JR Pickhardt, PJ AF Summers, Ronald M. Swift, Jeffrey A. Dwyer, Andrew J. Choi, J. Richard Pickhardt, Perry J. TI Normalized Distance Along the Colon Centerline: A Method for Correlating Polyp Location on CT Colonography and Optical Colonoscopy SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article; Proceedings Paper CT Digestive Disease Week/110th Annual Meeting of the American-Gastroenterological-Association CY MAY 30-JUN 04, 2009 CL Chicago, IL SP Amer Gastroenterol Assoc DE colorectal cancer screening; colon polyp; CT colonography; optical colonoscopy ID CURVED CROSS-SECTIONS; FEASIBILITY; SYSTEM AB OBJECTIVE. The ability to accurately locate a polyp found on CT colonography (CTC) at subsequent optical colonoscopy (OC) is an important part of the successful implementation of CTC for colorectal cancer screening. The purpose of this study was to determine whether a polyp's normalized distance along the colon centerline derived from CTC data can accurately predict its location on OC. MATERIALS AND METHODS. The polyp population consisted of 152 polyps in 121 patients. CTC polyp findings were verified by same-day segmentally-unblinded OC. Each polyp's normalized distance along the colon centerline was computed by dividing its distance from the anorectal junction measured along the colon centerline by the length of the colon at CTC. The predicted polyp location at OC was computed by multiplying the normalized distance along the colon centerline by the colon length at OC (i.e., the distance to the cecum as determined at full colonoscope insertion). The differences between the true and predicted polyp locations at OC were compared using paired Student's t tests, linear regression, prediction interval assessment, and Bland-Altman analyses. RESULTS. The differences between the true and predicted polyp locations at OC using the supine and prone CTC-normalized distances along the colon centerline were 2.2 +/- 10.5 cm (mean +/- SD; n = 136) and 1.5 +/- 10.5 cm (n = 135), respectively. The predicted location was within 10 cm of its true location for 71.3% (97/136) to 74.8% (101/135) of polyps and within 20 cm of its true location for 93.3% (126/135) to 93.4% (127/136) of polyps. CONCLUSION. By computing the normalized distance along the colon centerline of a polyp found at CTC, the location of a polyp at OC can be predicted to within 10 cm (i.e., 1 colonoscope mark) for the majority of polyps. C1 [Summers, Ronald M.; Swift, Jeffrey A.; Dwyer, Andrew J.] NIH, Ctr Clin, Bethesda, MD 20892 USA. [Choi, J. Richard] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Pickhardt, Perry J.] Univ Wisconsin, Dept Radiol, Sch Med, Madison, WI 53706 USA. RP Summers, RM (reprint author), NIH, Ctr Clin, Bldg 10,Rm 1C368X,MSC 1182, Bethesda, MD 20892 USA. EM rms@nih.gov FU Intramural NIH HHS [Z01 CL040003-05, Z01 CL040003-06, ZIA CL040003-07, ZIA CL040003-08, ZIA CL040003-09] NR 15 TC 17 Z9 18 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD NOV PY 2009 VL 193 IS 5 BP 1296 EP 1304 DI 10.2214/AJR.09.2611 PG 9 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 508ST UT WOS:000270956700015 PM 19843745 ER PT J AU Summers, RM Liu, JM Yao, JH Brown, L Choi, JR Pickhardt, PJ AF Summers, Ronald M. Liu, Jiamin Yao, Jianhua Brown, Linda Choi, J. Richard Pickhardt, Perry J. TI Automated Measurement of Colorectal Polyp Height at CT Colonography: Hyperplastic Polyps Are Flatter Than Adenomatous Polyps SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article; Proceedings Paper CT 94th Scientific Assembly and Annual Meeting of the Radiological-Society-of-North-America CY NOV 30-DEC 05, 2008 CL Chicago, IL SP Radiol Soc N Amer DE automated size measurement; colonoscopy; colorectal cancer screening; CT colonography; optical colonoscopy ID VIRTUAL COLONOSCOPY; ASYMPTOMATIC ADULTS; MISS RATE; IN-VITRO; COLON; LESIONS; PREVALENCE; MANAGEMENT; MODEL; RATES AB OBJECTIVE. Hyperplastic polyps are more difficult to detect than adenomatous polyps at CT colonography (CTC), and it has been theorized that this difference in detectability is because hyperplastic polyps are flatter. Using automated software that computes polyp height, we determined whether hyperplastic colonic polyps on CTC are indeed flatter than adenomatous polyps of comparable width. MATERIALS AND METHODS. At three medical centers, 1,186 patients underwent oral contrast-enhanced CTC and same-day optical colonoscopy (OC) with segment unblinding for colorectal cancer screening. One hundred eighty-five of the patients had at least one hyperplastic or adenomatous polyp 6-10 mm visible at both OC and CTC, where size was determined by a calibrated guidewire at OC. To assess flatness, the heights of the polyps at CTC were measured using a validated automated software program. The heights and height-to-width ratios of the hyperplastic polyps were compared with those of the adenomatous polyps using a Student's t test (two-tailed, unpaired, unequal variance). RESULTS. There were 176 adenomatous and 83 hyperplastic polyps visible at segment-unblinded OC. The fraction of these polyps that were measurable at CTC using the automated software was not significantly different for adenomatous versus hyperplastic polyps (158/176 [89.8%] vs 73/87 [83.9%], respectively; p = 0.2). The average height-to-width ratios using automated width measurements were 15% less for hyperplastic polyps: 0.39 +/- 0.20 (n = 158) and 0.33 +/- 0.19 (n = 73) for adenomatous and hyperplastic polyps, respectively (p = 0.03). When polyps of comparable OC size or CTC width were considered, the heights of hyperplastic polyps were up to 27% less than those of adenomatous polyps. CONCLUSION. For 6-10 mm polyps of a given size as determined by OC or a given width at CTC, hyperplastic polyps tend to be flatter (i.e., have lower height) compared with adenomatous polyps. C1 [Summers, Ronald M.; Liu, Jiamin; Yao, Jianhua; Brown, Linda] NIH, Ctr Clin, Bethesda, MD 20892 USA. [Choi, J. Richard] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Pickhardt, Perry J.] Univ Wisconsin, Dept Radiol, Sch Med, Madison, WI 53706 USA. RP Summers, RM (reprint author), NIH, Ctr Clin, Bldg 10,Rm 1C368X,MSC 1182, Bethesda, MD 20892 USA. EM rms@nih.gov FU Intramural NIH HHS [Z01 CL040003-05, Z01 CL040003-06, ZIA CL040003-07, ZIA CL040003-08, ZIA CL040003-09] NR 32 TC 11 Z9 11 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD NOV PY 2009 VL 193 IS 5 BP 1305 EP 1310 DI 10.2214/AJR.09.2442 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 508ST UT WOS:000270956700016 PM 19843746 ER PT J AU Bochicchio, G Kilbourne, M Kuehn, R Keledjian, K Hess, J Scalea, T AF Bochicchio, Grant Kilbourne, Michael Kuehn, Reed Keledjian, Kaspar Hess, John Scalea, Thomas TI Use of a modified chitosan dressing in a hypothermic Coagulopathic grade V liver injury model SO AMERICAN JOURNAL OF SURGERY LA English DT Article DE Chitosan; Hemorrhage; Advance hemostasis ID DAMAGE CONTROL SURGERY; FIBRIN SEALANT DRESSINGS; BLOOD-LOSS; RESUSCITATION VOLUME; PERIHEPATIC PACKING; HEMORRHAGE CONTROL; HEMOSTATIC AGENTS; TRAUMA; SWINE; MORTALITY AB BACKGROUND: Exsanguination from hepatic trauma is exacerbated by the lethal triad of acidosis, coagulopathy, and hypothermia. We evaluated the application of a modified chitosan dressing in a hypothermic coagulopathic model of grade V liver injury. METHODS: Subject swine underwent induced hypothermic coagulopathy followed by standardized grade V liver injuries. A modified chitosan dressing was applied and compared with standard packing. RESULTS: Pretreatment temperature, activated clotting time, and blood loss were similar between groups. Post treatment blood loss was significantly less and resuscitation mean arterial pressure were significantly greater in the modified chitosan group (P < .0001 and P < .018, respectively). Mean fluid resuscitative volume was significantly less in the modified chitosan group (P < .0056). Hemostasis was achieved on average 5.2 minutes following modified chitosan and never achieved with standard packing. At 1 hour post injury, all treatment animals survived compared with half of controls. CONCLUSIONS: Modified chitosan dressings provide simple rapid treatment of life-threatening liver injuries. (C) 2009 Elsevier Inc. All rights reserved. C1 [Bochicchio, Grant; Keledjian, Kaspar; Hess, John; Scalea, Thomas] Univ Maryland, Dept Surg, Baltimore, MD 21201 USA. [Kilbourne, Michael; Kuehn, Reed] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Bochicchio, G (reprint author), Univ Maryland, Dept Surg, Baltimore, MD 21201 USA. EM gbochicchio@umm.edu NR 30 TC 9 Z9 11 U1 0 U2 8 PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC PI BRIDGEWATER PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA SN 0002-9610 J9 AM J SURG JI Am. J. Surg. PD NOV PY 2009 VL 198 IS 5 BP 617 EP 622 DI 10.1016/j.amjsurg.2009.07.028 PG 6 WC Surgery SC Surgery GA 522KY UT WOS:000271997900008 PM 19887188 ER PT J AU Se, Y Lon, C Socheat, D Bethell, D Sriwichai, S Saunders, D Tyner, S Darapiseth, S Khemawoot, P Lin, J Poeu, S Sarim, S Timmermans, A Rutvisuttinunt, W Teja-Isavadharm, P Schaecher, K Smith, B Fukuda, M AF Se, Youry Lon, Chanthap Socheat, Duong Bethell, Delia Sriwichai, Sabaithip Saunders, David Tyner, Stuart Darapiseth, Sea Khemawoot, Phisit Lin, Jessica Poeu, Sok Sarim, Ses Timmermans, Ans Rutvisuttinunt, Wiriya Teja-Isavadharm, Paktiya Schaecher, Kurt Smith, Bryan Fukuda, Mark TI EFFECTS OF INCREASING ARTESUNATE DOSE IN SEVEN-DAY MONOTHERAPY REGIMENS ON TREATMENT RESPONSE IN CAMBODIAN PATIENTS WITH UNCOMPLICATED FALCIPARUM MALARIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Se, Youry; Lon, Chanthap; Bethell, Delia; Sriwichai, Sabaithip; Saunders, David; Tyner, Stuart; Khemawoot, Phisit; Lin, Jessica; Timmermans, Ans; Rutvisuttinunt, Wiriya; Teja-Isavadharm, Paktiya; Schaecher, Kurt; Smith, Bryan; Fukuda, Mark] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Socheat, Duong; Darapiseth, Sea; Poeu, Sok] Ctr Parasitol Entomol & Malaria Control, Pnom Penh, Cambodia. [Sarim, Ses] Tasanh Hlth Ctr, Samlot, Cambodia. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 22 BP 6 EP 7 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700023 ER PT J AU Van Panhuis, W Gibbons, RV Endy, T Burke, DS Cummings, DA AF Van Panhuis, Wilbert Gibbons, Robert V. Endy, Tim Burke, Donald S. Cummings, Derek A. TI ASSESSING THE ACCURACY OF INFERRING THE SEROTYPE OF DENGUE VIRUS INFECTIONS BASED ON PRE- AND POST-INFECTION NEUTRALIZING ANTIBODY TITERS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Van Panhuis, Wilbert; Cummings, Derek A.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Endy, Tim] SUNY Buffalo, Buffalo, NY 14260 USA. [Burke, Donald S.] Univ Pittsburgh, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 32 BP 9 EP 9 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700033 ER PT J AU Miller, RS Li, QG Cantilena, LR Leary, KJ Saviolakis, GA Melendez, V Weina, PJ AF Miller, R. Scott Li, Qigui Cantilena, Louis R. Leary, Kevin J. Saviolakis, George A. Melendez, Victor Weina, Peter J. TI PHARMACOKINETIC PROFILES OF ARTESUNATE FOLLOWING MULTIPLE INTRAVENOUS DOSES OF TWO, FOUR AND EIGHT MG/KG IN HEALTHY VOLUNTEERS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Miller, R. Scott; Li, Qigui; Melendez, Victor; Weina, Peter J.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Cantilena, Louis R.; Leary, Kevin J.; Saviolakis, George A.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 67 BP 19 EP 19 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700068 ER PT J AU Madiyarov, RS Khodiev, AV Ibadova, GA Mason, C AF Madiyarov, Ruslan S. Khodiev, Aybek V. Ibadova, Gulnara A. Mason, C. TI PREVALENCE OF I CLASS INTEGRON AMONG SHIGELLA FLEXNERI AND S. SONNEI IN UZBEKISTAN SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Madiyarov, Ruslan S.; Khodiev, Aybek V.; Ibadova, Gulnara A.] Sci Res Inst Epidemiol Microbiol & Infect Dis, Tashkent, Uzbekistan. [Mason, C.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 74 BP 21 EP 21 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700075 ER PT J AU Myint, HY Ohrt, C Walker, L White, N Magill, A AF Myint, Hla Y. Ohrt, Colin Walker, Larry White, Nick Magill, Alan TI CLINICAL STUDIES ON PRIMAQUINE-INDUCED HEMOLYSIS IN G6PD-DEFICIENT PATIENTS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Myint, Hla Y.; Ohrt, Colin; Magill, Alan] Walter Reed Army Inst Res, Silver Spring, MD USA. [Walker, Larry] Univ Mississippi, University, MS 38677 USA. [White, Nick] Mahidol Univ, Mahidol Oxford Res Unit, Bangkok 10700, Thailand. RI White, Nicholas/I-4629-2012 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 155 BP 44 EP 44 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700155 ER PT J AU Li, QG Si, YZ Xie, L Zhang, J Weina, PJ AF Li, Qigui Si, Yuanzheng Xie, Lisa Zhang, Jing Weina, Peter J. TI SIMILAR EMBRYONIC TOXICITY AND COMPARABLE PHARMACOKINETICS OF ARTESUNATE FOLLOWING MULTIPLE INTRAVENOUS AND INTRAMUSCULAR DOSES IN PREGNANT RATS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Li, Qigui; Si, Yuanzheng; Xie, Lisa; Zhang, Jing; Weina, Peter J.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 2 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 161 BP 45 EP 46 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700161 ER PT J AU Li, QG Gu, C Zhang, J Xie, LH Weina, PJ AF Li, Qigui Gu, Charles Zhang, Jing Xie, Lisa H. Weina, Peter J. TI METABOLIC STABILITIES AND METABOLITE PROFILES OF ARTESUNIC ACID (AS) AND ARTELINIC ACID (AL) IN CRYOPRESERVED HUMAN HEPATOCYTES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Li, Qigui; Gu, Charles; Zhang, Jing; Xie, Lisa H.; Weina, Peter J.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 164 BP 46 EP 47 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700164 ER PT J AU Xie, LH Zhang, J Weina, PJ Li, QG AF Xie, Lisa H. Zhang, Jing Weina, Peter J. Li, Qigui TI IDENTIFICATION AND VALIDATION OF THE PLASMODIUM CELL-CYCLE IN BLOOD STAGE BY FLOW CYTOMETRY IN COMPARISON TO OPTICAL MICROSCOPY SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Xie, Lisa H.; Zhang, Jing; Weina, Peter J.; Li, Qigui] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 162 BP 46 EP 46 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700162 ER PT J AU Zhang, J Xie, LH Melendez, V Li, QG Weina, PJ AF Zhang, Jing Xie, Lisa H. Melendez, Victor Li, Qigui Weina, Peter J. TI IMPROVING RELATIVE BIOAVAILABILITY OF ORAL WR299666 BY REDUCING PARTICLE SIZE USING HOMOGENIZER AND ULTRA-SONICATOR SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Zhang, Jing; Xie, Lisa H.; Melendez, Victor; Li, Qigui; Weina, Peter J.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 163 BP 46 EP 46 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700163 ER PT J AU Macareo, LR Luang, KM Miller, RS Cheah, PY Yuentrakul, P Nosten, F AF Macareo, Louis R. Luang, Khin M. Miller, R. Scott Cheah, Phaik Yeong Yuentrakul, Prayoon Nosten, Francois TI TRIANGULAR TEST DESIGN TO EVALUATE TINIDAZOLE IN THE PREVENTION OF PLASMODIUM VIVAX RELAPSE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Macareo, Louis R.; Miller, R. Scott] Walter Reed Army Inst Res, Silver Spring, MD USA. [Luang, Khin M.; Nosten, Francois] Shoklo Malaria Res Unit, Mae Sot, Thailand. [Cheah, Phaik Yeong] Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, CCVTM, Oxford, England. [Yuentrakul, Prayoon] Mahidol Univ, Fac Trop Med, Bangkok, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 165 BP 47 EP 47 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700165 ER PT J AU Bhonsle, J Tekwani, B Sampath, A Walker, L Ohrt, C Magill, A AF Bhonsle, Jayendra Tekwani, Babu Sampath, Aruna Walker, Larry Ohrt, Colin Magill, Alan TI 3D-QSAR MODELS TO PREDICT IN VITRO ANTIMALARIAL EFFICACY AND METHEMOGLOBIN TOXICITY OF 8-AMINOQUINOLINE ANALOGS AND DERIVATIVES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Bhonsle, Jayendra; Ohrt, Colin; Magill, Alan] Walter Reed Army Inst Res, Silver Spring, MD USA. [Tekwani, Babu; Sampath, Aruna; Walker, Larry] Univ Mississippi, Natl Ctr Nat Prod Res, University, MS 38677 USA. RI Bhonsle, Jayendra/A-9139-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 168 BP 48 EP 48 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700168 ER PT J AU Rutvisuttinunt, W Tyner, SD Yingyern, K Chaichana, P Fukuda, MM Schaecher, KE AF Rutvisuttinunt, Wiriya Tyner, Stuart D. Yingyern, Kritsanai Chaichana, Panjaporn Fukuda, Mark M. Schaecher, Kurt E. TI PLASMODIUM FALCIPARUM W2 AS A STANDARD LABORATORY CLONE FOR HRP2 (HISTIDINE-RICH PROTEIN 2)-ELISA BASED DRUG SENSITIVITY ASSAY SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Rutvisuttinunt, Wiriya; Tyner, Stuart D.; Yingyern, Kritsanai; Chaichana, Panjaporn; Fukuda, Mark M.; Schaecher, Kurt E.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 179 BP 50 EP 51 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700179 ER PT J AU Phasomkusolsil, S AF Phasomkusolsil, Siriporn TI INSECTARY MAINTENANCE OF ASIAN MALARIA VECTORS: AN EVALUATION OF THE EFFECTS OF BLOODMEAL SOURCE ON FEEDING, MORTALITY, FECUNDITY AND EGG HATCHING RATES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Phasomkusolsil, Siriporn] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 244 BP 68 EP 69 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700244 ER PT J AU Murray, CK Gray, MR Mende, K Pimentel, G Parker, T Samir, A Rahman, BA Hospenthal, DR AF Murray, Clinton K. Gray, Michael R. Mende, Katrin Pimentel, Guillermo Parker, Tina Samir, Ahmed Rahman, Bassem Abdel Hospenthal, Duane R. TI EVALUATION OF THE USE OF EGYPTIAN LEPTOSPIRA ISOLATES IN THE MICROSCOPIC AGGLUTINATION TESTING (MAT) DIAGNOSIS OF LEPTOSPIROSIS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Murray, Clinton K.; Hospenthal, Duane R.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Gray, Michael R.] USA, Vet Command, Ft Sam Houston, TX USA. [Mende, Katrin] Infect Dis Clin Res Program, Bethesda, MD USA. [Pimentel, Guillermo; Parker, Tina; Samir, Ahmed; Rahman, Bassem Abdel] NAMRU3, Cairo, Egypt. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 269 BP 76 EP 76 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700269 ER PT J AU Gire, SK Purkayastha, A Goff, J Olsen, V Damon, I Huggins, J Muyembe, JJ Hensley, L Rubins, K AF Gire, Stephen K. Purkayastha, Anjan Goff, Jay Olsen, Vicki Damon, Inger Huggins, John Muyembe, Jean-Jacque Hensley, Lisa Rubins, Kate TI HUMAN MONKEYPOX GENOMIC DIVERGENCE AND DETERMINANTS OF PATHOGENICITY SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Gire, Stephen K.; Purkayastha, Anjan; Rubins, Kate] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA. [Goff, Jay; Olsen, Vicki; Huggins, John; Hensley, Lisa] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Damon, Inger] Ctr Dis Control & Prevent, Atlanta, GA USA. [Muyembe, Jean-Jacque] Inst Natl Res Biomed, Kinshasa, Zaire. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 289 BP 81 EP 82 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700289 ER PT J AU Kelly, JX O'Neil, M Melendez, V Harris, E Ager, A Smilkstein, M Forquer, I Dodean, R Winter, R Hinrichs, D Riscoe, M AF Kelly, Jane X. O'Neil, Michael Melendez, Victor Harris, Erin Ager, Arba Smilkstein, Martin Forquer, Isaac Dodean, Rosie Winter, Rolf Hinrichs, Dave Riscoe, Mike TI A NOVEL ANTIMALARIAL CHEMOTYPE WITH EFFICACY AGAINST BOTH EXOERYTHROCYTIC AND ERYTHROCYTIC STAGES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Kelly, Jane X.; Forquer, Isaac; Dodean, Rosie; Winter, Rolf; Hinrichs, Dave; Riscoe, Mike] Portland VA Med Ctr, Portland, OR USA. [O'Neil, Michael; Melendez, Victor; Harris, Erin] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. [Ager, Arba] Univ Miami, Sch Med, Miami, FL USA. [Smilkstein, Martin] Oregon Translat Res & Drug Dev Inst, Portland, OR USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 295 BP 83 EP 83 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700295 ER PT J AU Fracisco, SD Gettayacamin, M Melendez, V Li, QG Khemawoot, P Smith, BL Saunders, D Bennett, K McCalmont, W Lanteri, C Dow, G Rothstein, Y Craft, C Teja-isavadharm, P Rawiwan, I Magill, A Lin, AJ Bathurst, I Westerman, R Ohrt, C AF Fracisco, Susan D. Gettayacamin, Montip Melendez, Victor Li, Qigui Khemawoot, Pisit Smith, Bryan L. Saunders, David Bennett, Kent McCalmont, William Lanteri, Charlotte Dow, Geoffrey Rothstein, Yarrow Craft, Carl Teja-isavadharm, Paktiya Rawiwan, Imerbsin Magill, Alan Lin, A. J. Bathurst, Ian Westerman, Richard Ohrt, Colin TI MIRINCAMYCIN: REASSESSMENT OF A PROMISING ANTIMALARIAL AGENT WITH POTENTIAL IN A PLASMODIUM CYNOMOLGI RELAPSING MALARIA MONKEY MODEL SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Fracisco, Susan D.; Melendez, Victor; Li, Qigui; Smith, Bryan L.; Bennett, Kent; McCalmont, William; Lanteri, Charlotte; Dow, Geoffrey; Rothstein, Yarrow; Magill, Alan; Lin, A. J.; Ohrt, Colin] WRAIR Expt Therapeut, Silver Spring, MD USA. [Gettayacamin, Montip; Khemawoot, Pisit; Saunders, David; Teja-isavadharm, Paktiya; Rawiwan, Imerbsin] Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Craft, Carl; Bathurst, Ian] Med Malaria Venture, Geneva, Switzerland. [Westerman, Richard] MALDEVCO, Kalamazoo, MI USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 298 BP 84 EP 84 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700298 ER PT J AU Ray, P Zhang, P Gao, XG Ishida, H Chua, A Amnuaysirikul, J Weina, PJ Grogl, M Ohrt, C Sampath, A Magill, AJ AF Ray, Prabhati Zhang, Peng Gao, Xiugong Ishida, Hiroshi Chua, Aileen Amnuaysirikul, Jack Weina, Peter J. Grogl, Max Ohrt, Colin Sampath, Aruna Magill, Alan J. TI AN IN VIVO GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD)-DEFICIENT MOUSE MODEL TO PREDICT THE HEMOLYTIC TOXICITY OF PRIMAQUINE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Ray, Prabhati; Zhang, Peng; Gao, Xiugong; Ishida, Hiroshi; Chua, Aileen; Amnuaysirikul, Jack; Weina, Peter J.; Grogl, Max; Ohrt, Colin; Magill, Alan J.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Sampath, Aruna] Univ Mississippi, University, MS 38677 USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 297 BP 84 EP 84 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700297 ER PT J AU Stephens, HA Vejbaesya, S Luangtrakool, P Luangtrakool, K Kalayanarooj, S Vaughn, DW Endy, TP Mammen, MP Greens, S Libraty, DH Ennis, FA Rothman, AL AF Stephens, Henry A. Vejbaesya, Sasijit Luangtrakool, Panpimon Luangtrakool, Komon Kalayanarooj, Siripen Vaughn, David W. Endy, Timothy P. Mammen, Mammen P. Greens, Sharone Libraty, Daniel H. Ennis, Francis A. Rothman, Alan L. TI TUMOR NECROSIS FACTOR (TNF) AND LYMPHOTOXIN-A (LTA) GENE ASSOCIATIONS WITH DENGUE VIRUS INFECTION IN ETHNIC THAIS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Stephens, Henry A.] UCL, London, England. [Vejbaesya, Sasijit; Luangtrakool, Panpimon; Luangtrakool, Komon] Mahidol Univ, Sch Med, Dept Transfus Med, Bangkok 10700, Thailand. [Vejbaesya, Sasijit; Luangtrakool, Panpimon; Luangtrakool, Komon] Mahidol Univ, Siriraj Hosp, Dept Transfus Med, Bangkok 10700, Thailand. [Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. [Vaughn, David W.; Endy, Timothy P.; Mammen, Mammen P.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Greens, Sharone; Libraty, Daniel H.; Ennis, Francis A.; Rothman, Alan L.] Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 355 BP 101 EP 102 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700355 ER PT J AU Cao, J Kaneko, O Thongkukiatkul, A Tachibana, M Otsuki, H Sattabongkot, J Gao, Q Tsuboi, T Torii, M AF Cao, Jun Kaneko, Osamu Thongkukiatkul, Amporn Tachibana, Mayumi Otsuki, Hitoshi Sattabongkot, Jetsumon Gao, Qi Tsuboi, Takafumi Torii, Motomi TI PLASMODIUM VIVAX RHOPTRY NECK PROTEIN (PVRON2) EXPRESSED AT BOTH ERYTHROCYTIC AND PRE-ERYTHROCYTIC INVASIVE PARASITES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Cao, Jun; Gao, Qi] Jiangsu Inst Parasit Dis, Wuxi, Peoples R China. [Kaneko, Osamu] Nagasaki Univ, Inst Trop Med, Dept Protozool, Nagasaki 852, Japan. [Thongkukiatkul, Amporn] Burapha Univ, Fac Sci, Dept Biol, Chon Buri, Thailand. [Tachibana, Mayumi; Otsuki, Hitoshi; Torii, Motomi] Ehime Univ, Sch Med, Dept Mol Parasitol, Toon, Japan. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Tsuboi, Takafumi] Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime, Japan. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 372 BP 106 EP 107 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700372 ER PT J AU Turell, MJ Dave, K Dave, S Mayda, M Parker, Z Coleman, RE Strickman, D AF Turell, Michael J. Dave, Kirti Dave, Sonia Mayda, Maria Parker, Zahra Coleman, Russell E. Strickman, Daniel TI EVALUATION OF NOVEL DIPSTICK ASSAYS FOR THE DETECTION OF RIFT VALLEY FEVER VIRUS IN MOSQUITOES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Turell, Michael J.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Dave, Kirti; Dave, Sonia] VecTOR Test Syst Inc, Thousand Oaks, CA USA. [Mayda, Maria; Parker, Zahra] Walter Reed Army Inst Res, Silver Spring, MD USA. [Coleman, Russell E.] USA, Med Mat Dev Act, Ft Detrick, MD USA. [Strickman, Daniel] USDA, Beltsville, MD 20705 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 386 BP 111 EP 111 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700386 ER PT J AU Koka, HS Turell, M Lutomiah, J Makio, A Muthoni, M Mutisya, J Yalwala, S Limbaso, SK Schnabel, D Sang, R AF Koka, Hellen S. Turell, Micheal Lutomiah, Joel Makio, Albina Muthoni, Milka Mutisya, James Yalwala, Santos Limbaso, Samson K. Schnabel, David Sang, Rosemary TI EVALUATION OF KENYAN MOSQUITO SPECIES AS VECTORS OF WEST NILE VIRUS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Koka, Hellen S.; Makio, Albina; Mutisya, James; Yalwala, Santos; Schnabel, David] US Army Med Res Unit Kenya, Nairobi, Kenya. [Turell, Micheal] USA, Med Res Inst Infect Dis, Frederick, MD USA. [Lutomiah, Joel; Muthoni, Milka; Limbaso, Samson K.; Sang, Rosemary] Kenya Govt Med Res Ctr, Nairobi, Kenya. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 392 BP 112 EP 112 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700392 ER PT J AU Blaylock, JM Maranich, AM Bauer, K Polhemus, M Martinez, LJ Seriwatana, J Waitumbi, J Walsh, D Lynch, J AF Blaylock, Jason M. Maranich, Ashley M. Bauer, Kristen Polhemus, Mark Martinez, Luis J. Seriwatana, Jitvimal Waitumbi, John Walsh, Douglas Lynch, Julia TI DENGUE VIRUS SEROPREVALENCE AND SEROINCIDENCE AMONG KENYAN CHILDREN SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Blaylock, Jason M.; Maranich, Ashley M.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Bauer, Kristen; Martinez, Luis J.; Seriwatana, Jitvimal; Lynch, Julia] Walter Reed Army Inst Res, Silver Spring, MD USA. [Polhemus, Mark; Waitumbi, John; Walsh, Douglas] US Army Med Res Unit Kenya, Kenya Med Res Unit, Walter Reed Project, Kisumu, Kenya. NR 0 TC 0 Z9 0 U1 1 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 426 BP 122 EP 122 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700426 ER PT J AU Clark, DV Ismayilov, A Bakhishova, S Hajiyev, H Nuriyev, T Piraliyev, S Bagirov, S Aslanova, A Qasimov, M Hepburn, MJ AF Clark, Danielle V. Ismayilov, Afrail Bakhishova, Sevinj Hajiyev, Huseyn Nuriyev, Tahir Piraliyev, Saleh Bagirov, Sadigulla Aslanova, Afag Qasimov, Maqsud Hepburn, Matthew J. TI UNDER-UTILIZATION OF HEALTH CARE SERVICES FOR INFECTIOUS DISEASE SYNDROMES IN RURAL AZERBAIJAN SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Clark, Danielle V.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Ismayilov, Afrail; Bakhishova, Sevinj; Hajiyev, Huseyn; Qasimov, Maqsud] Antiplague Stn, Baku, Azerbaijan. [Nuriyev, Tahir; Piraliyev, Saleh; Bagirov, Sadigulla] Ctr Hyg & Epidemiol, Qusar, Xachmaz, Azerbaijan. [Aslanova, Afag] Raytheon Tech Serv Co, Baku, Azerbaijan. [Hepburn, Matthew J.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 451 BP 129 EP 129 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700451 ER PT J AU Saunders, D Khemawoot, P Rasameesoraj, M Melendez, V Imerbsin, R Ohrt, C Fracisco, S Teja-Isavadharm, P AF Saunders, David Khemawoot, Phisit Rasameesoraj, Maneerat Melendez, Victor Imerbsin, Rawiwan Ohrt, Colin Fracisco, Susan Teja-isavadharm, Paktiya TI ABSOLUTE BIOAVAILABILITY OF CIS-MIRINCAMYCIN AND TRANS-MIRINCAMYCIN IN HEALTHY RHESUS MONKEYS, AND EX-VIVO ANTIMALARIAL ACTIVITY AGAINST PLASMODIUM FALCIPARUM SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Saunders, David; Khemawoot, Phisit; Rasameesoraj, Maneerat; Imerbsin, Rawiwan; Teja-isavadharm, Paktiya] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Melendez, Victor; Ohrt, Colin; Fracisco, Susan] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 512 BP 146 EP 146 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700510 ER PT J AU Auliff, AM O'Neill, MT Gardiner, DL Adams, JH Cheng, Q AF Auliff, Alyson M. O'Neill, Michael T. Gardiner, Don L. Adams, John H. Cheng, Qin TI INVESTIGATION OF GENETIC MUTATIONS IN PLASMODIUM VIVAX DIHYDROFOLATE REDUCATASE AND SUSCEPTIBILITY TO CONVENTIONAL AND NEW ANTIFOLATE ANTIMALARIALS USING A PLASMODIUM FALCIPARUM EXPRESSION SYSTEM SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Auliff, Alyson M.; Cheng, Qin] Australian Army Malaria Inst, Dept Drug Resistance & Diagnost, Enoggera, Australia. [O'Neill, Michael T.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. [Gardiner, Don L.] Queensland Inst Med Res, Brisbane, Qld 4006, Australia. [Adams, John H.] Univ S Florida, Global Hlth Infect Dis Res Program, Tampa, FL USA. RI Gardiner, Don/G-4717-2010 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 527 BP 150 EP 150 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700525 ER PT J AU Stewart, VA Odour, M Dickson, L Koros, J Nyakoe, N Anyonje, E Otieno, L Bovill, M Scrimgeour, A Ogutu, B Polhemus, M Waitumbi, J Luckhart, S AF Stewart, V. Ann Odour, Margaret Dickson, Laura Koros, Joseph Nyakoe, Nancy Anyonje, Elizabeth Otieno, Lucas Bovill, Maria Scrimgeour, Angus Ogutu, Bernards Polhemus, Mark Waitumbi, John Luckhart, Shirley TI MALARIA AND HIV: RELATIVE RATES OF ASYMPTOMATIC FALCIPARUM GAMETOCYTEMIA AND HIV CARRIAGE IN THE BLOOD DONOR POPULATION IN NYANZA PROVINCE, KENYA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Stewart, V. Ann; Dickson, Laura; Koros, Joseph; Nyakoe, Nancy; Otieno, Lucas; Bovill, Maria; Ogutu, Bernards; Waitumbi, John] USAMRU K, Kisumu, Kenya. [Odour, Margaret; Anyonje, Elizabeth] Reg Blood Transfus Ctr, Kisumu, Kenya. [Scrimgeour, Angus] USARIEM, Natick, MA USA. [Polhemus, Mark] Walter Reed Army Inst Res, Silver Spring, MD USA. [Luckhart, Shirley] Univ Calif Davis, Davis, CA 95616 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 544 BP 155 EP 155 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700542 ER PT J AU Moon, J Deye, G Miller, L Fracisco, S Miller, RS Tosh, D Cummings, J Ohrt, C Magill, A AF Moon, James Deye, Gregory Miller, Lori Fracisco, Susan Miller, R. Scott Tosh, Donna Cummings, James Ohrt, Colin Magill, Alan TI MALARIA INFECTION IN INDIVIDUALS TAKING MEFLOQUINE DOES NOT INDUCE ANTIBODY RESPONSE TO MSP1(42) SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Moon, James; Deye, Gregory; Miller, Lori; Fracisco, Susan; Miller, R. Scott; Tosh, Donna; Cummings, James; Ohrt, Colin; Magill, Alan] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Moon, James/B-6810-2011 OI Moon, James/0000-0002-9274-4554 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 550 BP 156 EP 157 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700548 ER PT J AU Blatz, PJ Beckius, ML Mende, K Murray, CK Hospenthal, DR AF Blatz, Peter J. Beckius, Miriam L. Mende, Katrin Murray, Clinton K. Hospenthal, Duane R. TI ACTIVITY OF SELECTED ANTIMICROBIAL AGENTS, INCLUDING TWO EXPERIMENTAL KETOLIDES, AGAINST LEPTOSPIRA SEROVARS IN VITRO SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Blatz, Peter J.; Beckius, Miriam L.; Mende, Katrin; Murray, Clinton K.; Hospenthal, Duane R.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 611 BP 174 EP 174 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701027 ER PT J AU Soliman, A Azab, A Mohareb, E Saad, M Tjaden, J El-Mohamady, H Shuck-Lee, D Earhart, K Yingst, S AF Soliman, Atef Azab, Adel Mohareb, Emad Saad, Magdi Tjaden, Jeffrey El-Mohamady, Hanan Shuck-Lee, Deidra Earhart, Kenneth Yingst, Samuel TI FURTHER EVALUATION OF RVF MP12 LIVE-ATTENUATED VACCINE IN CATTLE AND SHEEP IN EGYPT SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Soliman, Atef; Mohareb, Emad; Saad, Magdi; Tjaden, Jeffrey; El-Mohamady, Hanan; Shuck-Lee, Deidra; Earhart, Kenneth] USN, Med Res Unit 3, New York, NY 09527 USA. [Azab, Adel] Vet Serum & Vaccine Res Inst, Cairo, Egypt. [Yingst, Samuel] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RI Shucklee, Deidra/B-8926-2011 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 649 BP 185 EP 185 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701065 ER PT J AU Anyamba, A Linthicum, KJ Small, J Pak, E Tucker, CJ Chretien, JP Britch, SC Breiman, R Hightower, A de La Rocque, S Formenty, P Haagsma, K Latham, M Lewandowski, HB Sang, R Schnabel, D Richardson, J AF Anyamba, Assaf Linthicum, Kenneth J. Small, Jennifer Pak, Edwin Tucker, Compton J. Chretien, Jean P. Britch, Seth C. Breiman, Robert Hightower, Allan de La Rocque, Stephan Formenty, Pierre Haagsma, Karl Latham, Mark Lewandowski, Henry B. Sang, Rosemary Schnabel, David Richardson, Jason TI PREDICTION, ASSESSMENT OF THE RIFT VALLEY FEVER ACTIVITY IN EAST AND SOUTHERN AFRICA 2006-2008 AND POSSIBLE VECTOR CONTROL STRATEGIES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Anyamba, Assaf; Small, Jennifer; Pak, Edwin; Tucker, Compton J.] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. [Linthicum, Kenneth J.; Britch, Seth C.] USDA ARS, Ctr Med Agr & Vet Entomol, Gainesville, FL USA. [Chretien, Jean P.] Dept Def Global Emerging Infect Surveillance & Re, Silver Spring, MD USA. [Breiman, Robert] CDC Kenya, Nairobi, Kenya. [Hightower, Allan; de La Rocque, Stephan] Food & Agr Org United Nations, Rome, Italy. [Formenty, Pierre] WHO, CH-1211 Geneva, Switzerland. [Haagsma, Karl] Youngstown Air Reserve Stn, Vienna, OH USA. [Latham, Mark] Manatee Cty Mosquito Control, W Palmento, FL USA. [Lewandowski, Henry B.] Chatharn Cty Mosquito Control, Savannah, GA USA. [Sang, Rosemary] Kenya Govt Med Res Ctr, Nairobi, Kenya. [Schnabel, David] USAMRU K GEIS, Nairobi, Kenya. [Richardson, Jason] US Army Med Component, Armed Forces Res Inst Med Sci, Bangkok, Thailand. RI Richardson, Jason/A-9441-2011 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 652 BP 186 EP 186 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701068 ER PT J AU Bodhidatta, L Shrestha, SK Dhakhwa, JR Shrestha, BR Srijan, A Mason, CJ AF Bodhidatta, Ladaporn Shrestha, Sanjaya K. Dhakhwa, Jyoti R. Shrestha, Bhola Ram Srijan, Apichai Mason, Carl J. TI IMPORTANCE OF VIRAL PATHOGENS IN EARLY CHILDHOOD DIARRHEA IN RURAL AND URBAN NEPAL SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Bodhidatta, Ladaporn; Srijan, Apichai; Mason, Carl J.] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand. [Shrestha, Sanjaya K.] Walter Reed AFRIMS, Res Unit Nepal WARUN, Kathmandu, Nepal. [Dhakhwa, Jyoti R.] Kanti Childrens Hosp, Kathmandu, Nepal. [Shrestha, Bhola Ram] Bharatpur Hosp, Bharatpur, Nepal. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 711 BP 204 EP 204 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701127 ER PT J AU Chretien, JP Buczak, AL Anyamba, A Small, J Philip, TL Jessup, C Nuckols, J Leyk, S Miller, M Lewis, SH AF Chretien, Jean-Paul Buczak, Anna L. Anyamba, Assaf Small, Jennifer Philip, Trudy L. Jessup, Christine Nuckols, John Leyk, Stefan Miller, Mark Lewis, Sheri H. TI FORECASTING CHOLERA EPIDEMICS IN AFRICA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Chretien, Jean-Paul] Walter Reed Army Inst Res, Silver Spring, MD 20771 USA. [Buczak, Anna L.; Philip, Trudy L.; Lewis, Sheri H.] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20892 USA. [Anyamba, Assaf; Small, Jennifer] NASA, Goddard Space Flight Ctr, Greenbelt, MD 80309 USA. [Jessup, Christine; Nuckols, John; Leyk, Stefan; Miller, Mark] NIH, Fogarty Int Ctr, Bethesda, MD USA. [Leyk, Stefan] Univ Colorado, Dept Geography, Boulder, CO 80309 USA. NR 0 TC 0 Z9 0 U1 1 U2 6 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 717 BP 206 EP 206 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701133 ER PT J AU Loaiza, J Gutierrez, L Correa, M Bermingham, E Scott, M Wilkerson, R Birnberg, L Grijalva, M Rovira, J Bickersmith, S Conn, JE AF Loaiza, Jose Gutierrez, Lina Correa, Margarita Bermingham, Eldredge Scott, Marilyn Wilkerson, Richard Birnberg, Lotty Grijalva, Mario Rovira, Jose Bickersmith, Sara Conn, Jan E. TI PLEISTOCENE GEOGRAPHIC SEPARATION IN EASTERN PANAMA AND NORTHERN COLOMBIA LEADS TO POPULATION STRUCTURE IN ANOPHELES (NYSSORHYNCHUS) ALBIMANUS (DIPTERA: CULICIDAE) SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Loaiza, Jose; Scott, Marilyn] McGill Univ, Montreal, PQ 20560, Canada. [Gutierrez, Lina; Correa, Margarita] Univ Antioquia, Escuela Microbiol, Medellin, Colombia. [Bermingham, Eldredge] Smithsonian Trop Res Inst, Balboa, 45701, Panama. [Wilkerson, Richard] Smithsonian Inst, Walter Reed Army Inst Res, Washington, DC USA. [Birnberg, Lotty] Pontif Catholic Univ Ecuador, Ctr Infect Dis Res, Quito, Ecuador. [Grijalva, Mario] Ohio Univ, Trop Dis Inst, Athens, OH USA. [Rovira, Jose] Inst Conmemorat Gorgas Estudios Salud, Panama City, Panama. [Bickersmith, Sara; Conn, Jan E.] New York State Dept Hlth, Wadsworth Ctr, Albany, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 718 BP 206 EP 207 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701134 ER PT J AU Leirana, MM Harlow, W Hildebrandt, J Silva-do-Nascimento, TF Lourenco-de-Oliveira, R Sallum, MAM Fritz, GN Ruiz, F Wilkerson, R Loaiza, JR Dantur, MJ Povoa, MAM Gutierrez-Builes, LA Correa, MO Conn, JE AF Leirana, Marta Moreno Harlow, Wesley Hildebrandt, Jessica Fernandes Silva-do-Nascimento, Teresa Lourenco-de-Oliveira, Ricardo Mureb Sallum, Maria Anice Fritz, Gary N. Ruiz, Freddy Wilkerson, Richard Loaiza, Jose R. Julia Dantur, Maria Povoa, Marinete A. M. Andrea Gutierrez-Builes, Lina Correa, Margarita O. Conn, Jan E. TI NEOTROPICAL ANOPHELES TRIANNULATUS COMPLEX: PHYLOGEOGRAPHY AND DEMOGRAPHIC HISTORY BASED ON MITOCHONDRIAL AND NUCLEAR MARKERS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Leirana, Marta Moreno; Harlow, Wesley; Hildebrandt, Jessica; Conn, Jan E.] New York Dept Hlth, Wadsworth Ctr, Albany, NY USA. [Fernandes Silva-do-Nascimento, Teresa; Lourenco-de-Oliveira, Ricardo] Inst Oswaldo Cruz Fiocruz, Dept Entomol, Rio De Janeiro, Brazil. [Mureb Sallum, Maria Anice] Univ Sao Paulo, Fac Saude Publ, Dept Epidemiol, BR-01255 Sao Paulo, Brazil. [Fritz, Gary N.] Eastern Illinois Univ, Dept Biol Sci, Charleston, IL 61920 USA. [Ruiz, Freddy; Wilkerson, Richard] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD USA. [Loaiza, Jose R.] Smithsonian Trop Res Inst, Balboa, Panama. [Julia Dantur, Maria] Univ Nacl Tucuman, Inst Super Entomol Dr Abraham Willink, Fac Ciencias, Nat & Inst Miguel Lillo, San Miguel De Tucuman, Argentina. [Povoa, Marinete A. M.] Inst Evandro Chagas, Seccao Parasitol, Belem, Para, Brazil. [Andrea Gutierrez-Builes, Lina; Correa, Margarita O.] Univ Antioquia, Grp Microbiol Mol, Escuela Microbiol, Medellin, Colombia. RI Sallum, Maria/B-8537-2012 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 722 BP 208 EP 208 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701138 ER PT J AU Jobe, O Schwenk, RJ Krzych, U AF Jobe, Ousman Schwenk, Robert J. Krzych, Urszula TI LIVER CCD8 alpha+DC FROM MICE IMMUNIZED WITH RADIATION-ATTENUATED PLASMODIUM BERGHEI SPOROZOITES MEDIATE THE INDUCTION OF LIVER EFFECTOR CD8(+) T CELLS AGAINST PRE-ERYTHROCYTIC STAGE INFECTION SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Jobe, Ousman; Schwenk, Robert J.; Krzych, Urszula] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 740 BP 214 EP 214 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701156 ER PT J AU Krzych, U Steers, N Lumsden, J Berenzon, D Liepinsh, D Schwenk, RJ AF Krzych, Urszula Steers, Nick Lumsden, Joanne Berenzon, Dmitri Liepinsh, Dmitry Schwenk, Robert J. TI IL-15 MAINTAINS A RESERVOIR OF CENTRAL MEMORY CD8 T CELLS THAT ARE REQUIRED FOR PROTRACTED PROTECTION AGAINST PLASMODIUM BERGHEI INFECTION SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Krzych, Urszula; Steers, Nick; Lumsden, Joanne; Berenzon, Dmitri; Liepinsh, Dmitry; Schwenk, Robert J.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Lumsden, Joanne/B-6475-2009 NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 739 BP 214 EP 214 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701155 ER PT J AU Saunders, D Li, QQ Carlson, M Xie, L Zheng, Q Zhang, J Mendez, J Tally, J Jiang, SP Weina, P Magill, A Grogl, M AF Saunders, David Li, Qiqui Carlson, Misty Xie, Lisa Zheng, Qiang Zhang, Jing Mendez, Juan Tally, John Jiang, Suping Weina, Peter Magill, Alan Grogl, Max TI ANTILEISHMANIAL ACTIVITY OF SELECTED FDA-APPROVED DRUGS IN A MURINE CUTANEOUS LEISHMANIASIS MODEL SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Saunders, David] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Li, Qiqui; Carlson, Misty; Xie, Lisa; Zheng, Qiang; Zhang, Jing; Mendez, Juan; Tally, John; Jiang, Suping; Weina, Peter; Magill, Alan; Grogl, Max] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 750 BP 217 EP 217 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701166 ER PT J AU Yarina, TR Myers, TE Lee, JS O'Guinn, ML Tsertsvadze, N Vephkhvadze, N Babuadze, G Sidamonidze, K Kokhreidze, M Donduashvili, M Richards, AL AF Yarina, Tamasin R. Myers, Todd E. Lee, John S. O'Guinn, Monica L. Tsertsvadze, Nicolas Vephkhvadze, Nino Babuadze, Giorgi Sidamonidze, Ketevan Kokhreidze, Maka Donduashvili, Marina Richards, Allen L. TI SURVEILLANCE OF RICKETTSIAL PATHOGENS ISOLATED FROM TICKS IN THE REPUBLIC OF GEORGIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Yarina, Tamasin R.; Myers, Todd E.; Richards, Allen L.] USN, Med Res Ctr, Silver Spring, MD USA. USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [O'Guinn, Monica L.] Armed Forces Inst Pathol, Washington, DC 20306 USA. [Tsertsvadze, Nicolas; Babuadze, Giorgi; Sidamonidze, Ketevan] Natl Ctr Dis Control, Tbilisi, Rep of Georgia. [Vephkhvadze, Nino; Kokhreidze, Maka; Donduashvili, Marina] Lab Minist Agr, Tbilisi, Rep of Georgia. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 754 BP 218 EP 218 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701170 ER PT J AU Mayda, ME Parker, Z Dave, K Turell, MJ Rowland, T Coleman, R Strickman, D AF Mayda, Maria E. Parker, Zahra Dave, Kirti Turell, Michael J. Rowland, Tobin Coleman, Russell Strickman, Daniel TI A RAPID ASSAY FOR THE DETECTION OF ALL FOUR DENV SEROTYPES IN MOSQUITOES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Mayda, Maria E.; Parker, Zahra; Rowland, Tobin] Walter Reed Army Inst Res, Silver Spring, MD USA. [Dave, Kirti] VecTOR Test Syst Inc, Thousand Oaks, CA USA. [Turell, Michael J.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Coleman, Russell] USA, Med Mat Dev Act, Ft Detrick, MD USA. [Strickman, Daniel] USDA ARS, Beltsville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 757 BP 219 EP 219 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701173 ER PT J AU Clark, DV Kuchuloria, T Akhvlediani, T Hepburn, MJ Pimentel, G Chokheli, M Mamuchishvili, N Imnadze, P AF Clark, Danielle V. Kuchuloria, Tinatin Akhvlediani, Tamuna Hepburn, Matthew J. Pimentel, Guillermo Chokheli, Maiko Mamuchishvili, Nana Imnadze, Paata TI LEPTOSPIROSIS IN THE REPUBLIC OF GEORGIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Clark, Danielle V.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Kuchuloria, Tinatin; Akhvlediani, Tamuna] Technol Management Co, Tbilisi, Rep of Georgia. [Hepburn, Matthew J.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Pimentel, Guillermo] US Naval Med Res Unit 3, Cairo, Egypt. [Chokheli, Maiko; Mamuchishvili, Nana; Imnadze, Paata] Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 773 BP 223 EP 224 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701189 ER PT J AU Caci, JB Tack, DM Lyons, A AF Caci, Jennifer B. Tack, Danielle M. Lyons, Arthur TI SEROPREVALENCE OF DENGUE IN UNITED STATES ARMY SPECIAL OPERATIONS COMMAND PERSONNEL SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Caci, Jennifer B.] USA Special Operat Command, Ft Bragg, NC USA. [Tack, Danielle M.] 98th Civil Affairs Battal, Ft Bragg, NC USA. [Lyons, Arthur] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Lyons, Arthur/B-8923-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 784 BP 226 EP 227 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701200 ER PT J AU Takhampunya, R Palmer, DR David, DA Barvir, A Lynch, J Jarman, RG Thomas, S Gibbons, RV Putnak, R Zhang, CL AF Takhampunya, Ratree Palmer, Dupeh R. David, David A. Barvir, A. Lynch, Julia Jarman, Richard G. Thomas, Stephen Gibbons, Robert V. Putnak, Robert Zhang, Chunlin TI PHENOTYPIC ANALYSIS OF DENGUE VIRUS ISOLATES ASSOCIATED WITH DENGUE FEVER AND DENGUE HEMORRHAGIC FEVER FOR CELLULAR ATTACHMENT REPLICATION AND INTERFERON SIGNALING ABILITY SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Takhampunya, Ratree; Palmer, Dupeh R.; David, David A.; Barvir, A.; Lynch, Julia; Thomas, Stephen; Putnak, Robert; Zhang, Chunlin] Walter Reed Army Inst Res, Silver Spring, MD USA. [Jarman, Richard G.; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 786 BP 227 EP 227 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701202 ER PT J AU Benenson, JD Gibbons, RV Nisalak, A Kalayanarooj, S Cummings, DA AF Benenson, Jon D. Gibbons, Robert V. Nisalak, Ananda Kalayanarooj S., Siripen Cummings, Derek A. TI SUSCEPTIBLE RECONSTRUCTION AND SEROTYPE SPECIFIC ESTIMATES OF THE TRANSMISSIBILITY AND SEASONALITY OF TRANSMISSION OF DENGUE VIRUSES IN THAILAND SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Benenson, Jon D.; Cummings, Derek A.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Gibbons, Robert V.; Nisalak, Ananda] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Kalayanarooj S., Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 796 BP 230 EP 230 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701212 ER PT J AU Alera, MTP AF Alera, Maria Theresa P. TI DENGUE SURVEILLANCE IN A TERTIARY HOSPITAL IN CEBU CITY, PHILIPPINES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Alera, Maria Theresa P.] US Army Med Component Armed Forces Res Inst Med S, Bangkok, Thailand. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 799 BP 231 EP 231 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701215 ER PT J AU Alera, MTP AF Alera, Maria Theresa P. TI JAPANESE ENCEPHALITIS IN THE PHILIPPINES: CHART REVIEW AND LABORATORY CONFIRMED HOSPITALIZED CASES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Alera, Maria Theresa P.] US Army Med Component, Armed Forces Res Inst Med Sci, Bangkok, Thailand. NR 0 TC 1 Z9 1 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 810 BP 233 EP 234 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701226 ER PT J AU Grant, RJ Baldwin, CD Turell, MJ Rossi, C Li, F Lovari, R Blyn, L Sampath, R Whitehouse, CA AF Grant, Rebecca J. Baldwin, Carson D. Turell, Michael J. Rossi, Cindy Li, Feng Lovari, Robert Blyn, Larry Sampath, Ranga Whitehouse, Chris A. TI DEVELOPMENT OF A BROAD SPECTRUM FLAVIVIRUS QUANTITATIVE DETECTION ASSAY USING RT-PCR/ELECTROSPRAY IONIZATION MASS SPECTROMETRY ON THE IBIS T5000 PLATFORM SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Grant, Rebecca J.; Baldwin, Carson D.; Turell, Michael J.; Rossi, Cindy; Whitehouse, Chris A.] USA, Med Res Inst Infect Dis, Frederick, MD USA. [Li, Feng; Lovari, Robert; Blyn, Larry; Sampath, Ranga] Ibis Biosci, Carlsbad, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 811 BP 234 EP 234 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701227 ER PT J AU Ager, A Ellis, B Mendez, J Magill, A Boodoo, R Lui, J Grogl, M AF Ager, Arba Ellis, Bill Mendez, Juan Magill, Alan Boodoo, Richard Lui, Jenbon Grogl, Max TI EVALUATION OF COMPOUNDS FOR CUTANEOUS LEISHMANIAL ACTIVITY IN BALB/C MICE INFECTED WITH LEISHMANIA MAJOR SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Ager, Arba; Boodoo, Richard; Lui, Jenbon] Univ Miami, Miami, FL USA. [Ellis, Bill; Mendez, Juan; Magill, Alan; Grogl, Max] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 833 BP 240 EP 240 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701248 ER PT J AU Bethell, D Se, Y Lon, C Socheat, D Saunders, D Darapiseth, S Lin, J Sriwichai, S Kuntawungin, W Poeu, S Lee, S Sarim, S Tyner, S Smith, B Fukuda, M AF Bethell, Delia Se, Youry Lon, Chanthap Socheat, Duong Saunders, David Darapiseth, Sea Lin, Jessica Sriwichai, Sabaithip Kuntawungin, Worachet Poeu, Sok Lee, Sue Sarim, Ses Tyner, Stuart Smith, Bryan Fukuda, Mark TI DOSE-DEPENDENT RISK OF NEUTROPENIA FOLLOWING SEVEN-DAY COURSES OF ARTESUNATE MONOTHERAPY IN ADULT CAMBODIAN PATIENTS WITH ACUTE FALCIPARUM MALARIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Bethell, Delia; Se, Youry; Lon, Chanthap; Saunders, David; Lin, Jessica; Sriwichai, Sabaithip; Kuntawungin, Worachet; Tyner, Stuart; Smith, Bryan; Fukuda, Mark] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Socheat, Duong; Darapiseth, Sea; Poeu, Sok] Ctr Parasitol Entomol & Malaria Control, Pnom Penh, Cambodia. [Lee, Sue] MORU, Bangkok, Thailand. [Sarim, Ses] Tasanh Hlth Ctr, Samlot, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 858 BP 247 EP 247 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701273 ER PT J AU Gutteridge, CE Sadowski, BW Baxter, MC O'Neil, MT McCalmont, WF Gerena, L AF Gutteridge, Clare E. Sadowski, Brett W. Baxter, Michael C. O'Neil, Michael T. McCalmont, William F. Gerena, Lucia TI IDENTIFICATION AND DEVELOPMENT OF A NOVEL CHEMICAL SERIES WITH ACTIVITY AGAINST BOTH BLOOD- AND LIVER-STAGES OF PLASMODIUM FALCIPARUM SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Gutteridge, Clare E.; Sadowski, Brett W.; Baxter, Michael C.] USN Acad, Annapolis, MD 21402 USA. [O'Neil, Michael T.; McCalmont, William F.; Gerena, Lucia] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S BP 251 EP 251 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701289 ER PT J AU Milner, EE Gardner, SR Bhonsle, JB Caridha, DP Carroll, D Gerena, L Gettayacamin, M Lanteri, CA Li, QQ Luong, T McCalmont, WF Melendez, V Moon, JK Roncal, NE Sousa, JC Tangteung, A Zeng, Q Zhang, J Wipf, P Xie, L Dow, GS AF Milner, Erin E. Gardner, Sean R. Bhonsle, Jayendra B. Caridha, Diana P. Carroll, Dustin Gerena, Lucia Gettayacamin, Montip Lanteri, Charlotte A. Li, Qiqui Luong, ThuLan McCalmont, William F. Melendez, Victor Moon, Jay K. Roncal, Norma E. Sousa, Jason C. Tangteung, Anchalee Zeng, Qiang Zhang, Jing Wipf, Peter Xie, Lisa Dow, Geoffrey S. TI NEXT GENERATION QUINOLINE METHANOLS FOR MALARIA CHEMOPROPHYLAXIS AND IPTX SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Milner, Erin E.; Gardner, Sean R.; Bhonsle, Jayendra B.; Caridha, Diana P.; Carroll, Dustin; Gerena, Lucia; Lanteri, Charlotte A.; Li, Qiqui; Luong, ThuLan; McCalmont, William F.; Melendez, Victor; Moon, Jay K.; Roncal, Norma E.; Sousa, Jason C.; Zeng, Qiang; Zhang, Jing; Xie, Lisa; Dow, Geoffrey S.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Gettayacamin, Montip; Tangteung, Anchalee] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Wipf, Peter] Univ Pittsburgh, Pittsburgh, PA USA. RI Bhonsle, Jayendra/A-9139-2011; Sousa, Jason/A-9177-2011 NR 0 TC 0 Z9 0 U1 2 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S BP 251 EP 251 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701288 ER PT J AU Jin, XN Carroll, D Luong, TL Black, G Jenkins, T Olmeda, R Reese, N Li, QG Xie, LS Zhang, J O'Neil, MT Kozar, MP Lin, AJ Ohrt, C Sousa, JC Melendez, V AF Jin, Xiannu Carroll, Dustin Luong, Thu-Lan Black, Gavin Jenkins, Tanya Olmeda, Raul Reese, Necole Li, Qigui Xie, Lisa Zhang, Jing O'Neil, Michael T. Kozar, Michael P. Lin, Ai J. Ohrt, Colin Sousa, Jason C. Melendez, Victor TI METABOLIC PROFILING OF PRIMAQUINE USING IN VITRO AND IN VIVO APPROACHES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Jin, Xiannu; Carroll, Dustin; Luong, Thu-Lan; Black, Gavin; Jenkins, Tanya; Olmeda, Raul; Reese, Necole; Li, Qigui; Xie, Lisa; Zhang, Jing; O'Neil, Michael T.; Kozar, Michael P.; Lin, Ai J.; Ohrt, Colin; Sousa, Jason C.; Melendez, Victor] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. RI Kozar, Michael/A-9155-2011; Sousa, Jason/A-9177-2011; Luong, Thu-Lan/A-9160-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S BP 253 EP 253 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701295 ER PT J AU Luong, TL Liu, XJ Lin, AJ Li, QG Xie, LS Zhang, J Olmeda, R Kozar, MP Sousa, JC Melendez, V AF Luong, Thu-Lan Liu, Xianjun Lin, Ai J. Li, Qigui Xie, Lisa Zhang, Jing Olmeda, Raul Kozar, Michael P. Sousa, Jason C. Melendez, Victor TI IN VITRO AND IN VIVO METABOLIC PROFILE OF TWO DEOXO-IMIDAZOLIDINEDIONE ANALOGS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Luong, Thu-Lan; Liu, Xianjun; Lin, Ai J.; Li, Qigui; Xie, Lisa; Zhang, Jing; Olmeda, Raul; Kozar, Michael P.; Sousa, Jason C.; Melendez, Victor] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. RI Kozar, Michael/A-9155-2011; Sousa, Jason/A-9177-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S BP 253 EP 254 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701297 ER PT J AU Sousa, JC Olmeda, R Carroll, D Black, G Jin, XN Reese, N Jenkins, T Wang, XH Sathunuru, R Zhang, L Lin, AJ Li, QG Xie, LS Zhang, J Kozar, MP Melendez, V AF Sousa, Jason C. Olmeda, Raul Carroll, Dustin Black, Gavin Jin, Xiannu Reese, Necole Jenkins, Tanya Wang, Xihong Sathunuru, Ramadas Zhang, Liang Lin, Ai J. Li, Qigui Xie, Lisa Zhang, Jing Kozar, Michael P. Melendez, Victor TI IN VITRO AND IN VIVO METABOLISM AND DISPOSITION STUDIES OF IMIDAZOLIDINEDIONE ANALOGS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Sousa, Jason C.; Olmeda, Raul; Carroll, Dustin; Black, Gavin; Jin, Xiannu; Reese, Necole; Jenkins, Tanya; Wang, Xihong; Sathunuru, Ramadas; Zhang, Liang; Lin, Ai J.; Li, Qigui; Xie, Lisa; Zhang, Jing; Kozar, Michael P.; Melendez, Victor] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. RI Kozar, Michael/A-9155-2011; Sousa, Jason/A-9177-2011 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S BP 253 EP 253 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701296 ER PT J AU Carroll, D Dow, GS Milner, E McCalmont, WF Lanteri, CA Roncal, NE Gerena, L Jin, XN Olmeda, R Reese, N Anova, L Asher, C Sousa, JC Melendez, V AF Carroll, Dustin Dow, Geoffrey S. Milner, Erin McCalmont, William F. Lanteri, Charlotte A. Roncal, Norma E. Gerena, Lucia Jin, Xiannu Olmeda, Raul Reese, Necole Anova, Lalaine Asher, Constance Sousa, Jason C. Melendez, Victor TI IN VITRO METABOLISM AND DISPOSITION EVALUATIONS OF QUINOLINE METHANOL ANALOGS OF MEFLOQUINE MODIFIED AT THE 4-POSITION SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Carroll, Dustin; Dow, Geoffrey S.; Milner, Erin; McCalmont, William F.; Lanteri, Charlotte A.; Roncal, Norma E.; Gerena, Lucia; Jin, Xiannu; Olmeda, Raul; Reese, Necole; Anova, Lalaine; Asher, Constance; Sousa, Jason C.; Melendez, Victor] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. RI Sousa, Jason/A-9177-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S BP 254 EP 254 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701298 ER PT J AU Saunders, D Deye, G Bennett, K Ohrt, C AF Saunders, David Deye, Gregory Bennett, Kent Ohrt, Colin TI DEVELOPMENT OF A NETWORK OF INVESTIGATORS TO STUDY ANTIMALARIAL PROPHYLAXIS IN THE ASIA-PACIFIC REGION SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Saunders, David] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Deye, Gregory; Bennett, Kent; Ohrt, Colin] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S BP 254 EP 254 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701299 ER PT J AU Spalding, MD Eyase, F Akala, H Bedno, S Coldren, RL Waters, NC Moss, WJ AF Spalding, Maroya D. Eyase, Fredrick Akala, Hoseah Bedno, Sheryl Coldren, Rodney L. Waters, Norman C. Moss, William J. TI RAPID INCREASES IN THE PREVALENCE OF PFDHFR AND PFDHPS MUTANT HAPLOTYPES DURING THE PERIOD OF SP USE AS THE FIRST-LINE ANTIMALARIAL IN KISUMU, KENYA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Spalding, Maroya D.; Moss, William J.] Johns Hopkins Sch Publ Hlth, Baltimore, MD USA. [Eyase, Fredrick; Akala, Hoseah; Bedno, Sheryl; Coldren, Rodney L.] USA, Res Unit Kenya, Nairobi, Kenya. [Waters, Norman C.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S BP 254 EP 255 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701300 ER PT J AU Rasameesoraj, M Tangthongchaiwiriya, K Saunders, D Fukuda, M Noedl, H Ringwald, P Teja-Isavadharm, P AF Rasameesoraj, Maneerat Tangthongchaiwiriya, Kuntida Saunders, David Fukuda, Mark Noedl, Harald Ringwald, Pascal Teja-Isavadharm, Paktiya TI VALIDATION OF PLATE COATING AND STORAGE TECHNIQUES FOR IN VITRO DRUG SENSITIVITY TESTING OF PIPERAQUINE, PYRONARIDINE, AND LUMIFANTRINE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Rasameesoraj, Maneerat; Tangthongchaiwiriya, Kuntida; Saunders, David; Fukuda, Mark; Teja-Isavadharm, Paktiya] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Noedl, Harald] Med Univ Vienna, Vienna, Austria. [Ringwald, Pascal] WHO, CH-1211 Geneva, Switzerland. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 894 BP 257 EP 257 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701309 ER PT J AU Tucker, MS Gerena, L Sorber, K Dimon, M Azizan, A Wang, ZN Cheng, Q Kyle, DE AF Tucker, Matthew S. Gerena, Lucia Sorber, Katherine Dimon, Michelle Azizan, Azliyati Wang, Zhinning Cheng, Qin Kyle, Dennis E. TI MOLECULAR CHARACTERIZATION OF RESISTANCE TO ARTEMISININ DRUGS IN PLASMODIUM FALCIPARUM SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Tucker, Matthew S.; Azizan, Azliyati; Kyle, Dennis E.] Univ S Florida, Tampa, FL USA. [Gerena, Lucia; Wang, Zhinning] Walter Reed Army Inst Res, Rockville, MD USA. [Sorber, Katherine; Dimon, Michelle] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Cheng, Qin] Australian Army Malaria Inst, Enoggera, Australia. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 892 BP 257 EP 257 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701307 ER PT J AU Tyner, S Rutvisuttinunt, W Yingyuen, K Chaichana, P Sundrakes, S Saingam, P Se, Y Bethell, D Sriwichai, S Lon, C Khemawoot, P Saunders, D Darapiseth, S Poeu, S Lin, J Schaecher, K Tejaisavadharm, P Smith, B Socheat, D Fukuda, MM AF Tyner, Stuart Rutvisuttinunt, Wiriya Yingyuen, Kritsanai Chaichana, Panjaporn Sundrakes, Siratchana Saingam, Piyaporn Se, Youry Bethell, Delia Sriwichai, Sabaithip Lon, Chanthap Khemawoot, Phisit Saunders, David Darapiseth, Sea Poeu, Sok Lin, Jessica Schaecher, Kurt Tejaisavadharm, Paktiya Smith, Bryan Socheat, Duong Fukuda, Mark M. TI IN VITRO DRUG SENSITIVITY-PHARMACODYNAMIC CORRELATES IN A CLINICAL TRIAL OF VARYING DOSES OF ARTESUNATE IN CAMBODIAN ADULT PATIENTS WITH UNCOMPLICATED PLASMODIUM FALCIPARUM MALARIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Tyner, Stuart; Rutvisuttinunt, Wiriya; Yingyuen, Kritsanai; Chaichana, Panjaporn; Sundrakes, Siratchana; Saingam, Piyaporn; Se, Youry; Bethell, Delia; Sriwichai, Sabaithip; Lon, Chanthap; Khemawoot, Phisit; Saunders, David; Lin, Jessica; Tejaisavadharm, Paktiya; Smith, Bryan; Fukuda, Mark M.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Darapiseth, Sea; Poeu, Sok; Socheat, Duong] Natl Ctr Parasitol Entomol & Malaria Control, Pnom Penh, Cambodia. [Schaecher, Kurt] 9th Area Med Lab, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 896 BP 258 EP 258 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701311 ER PT J AU Ockenhouse, EB Bergmann-Leitner, E Riley, M D'Ambrozio, J Lee, M Hu, X Wallqvist, A Graf, P Waitumbi, J Angov, E Ockenhouse, CF AF Ockenhouse, Eric B. Bergmann-Leitner, Elke Riley, Matthew D'Ambrozio, Jonathan Lee, M. Hu, X. Wallqvist, Anders Graf, Paul Waitumbi, John Angov, Evelina Ockenhouse, Christian F. TI GENETIC DIVERSITY IN THE PLASMODIUM FALCIPARUM AND P. VIVAX MALARIA CELTOS GENE FROM SOUTHEAST ASIA, AFRICA AND SOUTH AMERICA REVEALS A HIGHLY CONSERVED GENE WITH FOCAL REGIONS OF NOW SYNONOMOUS MUTATIONS UNDER IMMUNE SELECTIVE PRESSURE CONFIRMED BY GENE SEQUENCING, 3D STRUCTURE PREDICTION AND PEPTIDE MAPPING SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Ockenhouse, Eric B.] Bethesda Chevy Chase High Sch, Walter Reed Army Inst Res, Silver Spring, MD USA. [Bergmann-Leitner, Elke; Riley, Matthew; Angov, Evelina; Ockenhouse, Christian F.] USMMVP, Walter Reed Army Inst Res, Silver Spring, MD USA. [Lee, M.; Hu, X.; Wallqvist, Anders] MRMC, TATRC, Frederick, MD USA. [Graf, Paul] NMRCD Peru, Lima, Peru. [Waitumbi, John] USAMRU Kenya, Kisumu, Kenya. RI Bergmann-Leitner, Elke/B-3548-2011 OI Bergmann-Leitner, Elke/0000-0002-8571-8956 NR 0 TC 4 Z9 4 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 902 BP 260 EP 260 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701317 ER PT J AU Saunders, D Lon, C Buathong, N Sithy, N Se, Y Timmermans, A Lin, J Fukuda, M Socheat, D Bethel, D AF Saunders, David Lon, Chanthap Buathong, Nillawan Sithy, Ngo Se, Youry Timmermans, Ans Lin, Jessica Fukuda, Mark Socheat, Duong Bethel, Delia TI SEVERE MALARIA IN BATTAMBANG REFERRAL HOSPITAL, CAMBODIA FROM 2006 TO 2008 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Saunders, David; Buathong, Nillawan; Timmermans, Ans; Lin, Jessica; Fukuda, Mark; Bethel, Delia] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Lon, Chanthap; Se, Youry] Armed Forces Res Inst Med Sci, Phnom Penh, Cambodia. [Sithy, Ngo] Battambang Referral Hosp, Battambang, Cambodia. [Socheat, Duong] CNM, Phnom Penh, Cambodia. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 907 BP 261 EP 261 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701322 ER PT J AU Foley, M Harris, K Khore, M Andrew, C Anders, RF Dutta, S AF Foley, Michael Harris, Karen Khore, Madhavi Andrew, Coley Anders, Robin F. Dutta, Sheetij TI ENGINEERING APICAL MEMBRANE ANTIGEN-1 TO OVERCOME ANTIGENIC DIVERSITY IN THIS MALARIA VACCINE CANDIDATE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Foley, Michael; Harris, Karen; Khore, Madhavi; Andrew, Coley; Anders, Robin F.] La Trobe Univ, Melbourne, Vic, Australia. [Dutta, Sheetij] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 919 BP 265 EP 265 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701333 ER PT J AU Bergmann-Leitner, ES Laquer, KM Duncan, EH Savranskaya, T Mease, RM Polhemus, ME Ockenhouse, CF Angov, E AF Bergmann-Leitner, Elke S. Laquer, Kari M. Duncan, Elizabeth H. Savranskaya, Tatyana Mease, Ryan M. Polhemus, Mark E. Ockenhouse, Christian F. Angov, Evelina TI CELL TRAVERSAL PROTEIN FOR OOKINETES AND SPOROZOITES (CELTOS) FROM PLASMODIUM FALCIPARUM ELICITS PROTECTIVE IMMUNITY IN MICE AGAINST HETEROLOGOUS CHALLENGE WITH P. BERGHEI SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Bergmann-Leitner, Elke S.; Laquer, Kari M.; Duncan, Elizabeth H.; Savranskaya, Tatyana; Mease, Ryan M.; Polhemus, Mark E.; Ockenhouse, Christian F.; Angov, Evelina] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Bergmann-Leitner, Elke/B-3548-2011 OI Bergmann-Leitner, Elke/0000-0002-8571-8956 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 935 BP 269 EP 270 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701349 ER PT J AU Chowdhury, DR Angov, E Kariuki, T Kumar, N AF Chowdhury, Debabani Roy Angov, Evelina Kariuki, Thomas Kumar, Nirbhay TI A POTENT MALARIA TRANSMISSION BLOCKING VACCINE BASED ON CODON-HARMONIZED PFS48/45 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Chowdhury, Debabani Roy; Kumar, Nirbhay] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Angov, Evelina] Walter Reed Army Inst Res, Silver Spring, MD USA. [Kariuki, Thomas] Natl Museums Kenya, Inst Primate Res, Nairobi, Kenya. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 933 BP 269 EP 269 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701347 ER PT J AU Angov, E Duncan, EH Laquer, KM Mease, RM Bergmann-Leitner, ES AF Angov, Evelina Duncan, Elizabeth H. Laquer, Kari M. Mease, Ryan M. Bergmann-Leitner, Elke S. TI HETEROLOGOUS PRIME-BOOST STRATEGIES USING DIFFERENT ALLELES OF MSP1(42) TO OVERCOME ALLELE-SPECIFIC IMMUNITY SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Angov, Evelina; Duncan, Elizabeth H.; Laquer, Kari M.; Mease, Ryan M.; Bergmann-Leitner, Elke S.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Bergmann-Leitner, Elke/B-3548-2011 OI Bergmann-Leitner, Elke/0000-0002-8571-8956 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 937 BP 270 EP 270 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701351 ER PT J AU Deriso, E Bergmann-Leitner, ES Whittington, J Duncan, EH Boyle, K Savranskaya, T Alefantis, T Grewal, P DelVecchio, V Angov, E AF Deriso, Elizabeth Bergmann-Leitner, Elke S. Whittington, Jessica Duncan, Elizabeth H. Boyle, Katharine Savranskaya, Tatyana Alefantis, Timothy Grewal, Paul DelVecchio, Vito Angov, Evelina TI INACTIVATED ESCHERICHIA COLI EXPRESSING PLASMODIUM BERGHEI CSP EXPRESSED FROM DIFFERENT CELLULAR LOCALIZATIONS INDUCE DIFFERENTIAL IMMUNITY SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Deriso, Elizabeth; Bergmann-Leitner, Elke S.; Duncan, Elizabeth H.; Boyle, Katharine; Savranskaya, Tatyana; Angov, Evelina] Walter Reed Army Inst Res, Silver Spring, MD USA. [Whittington, Jessica; Alefantis, Timothy; Grewal, Paul; DelVecchio, Vito] Vital Probes Inc, Mayfield, PA USA. RI Bergmann-Leitner, Elke/B-3548-2011 OI Bergmann-Leitner, Elke/0000-0002-8571-8956 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 936 BP 270 EP 270 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701350 ER PT J AU Khan, F Mease, RM Legler, P Bergmann-Leitner, ES Angov, E AF Khan, Farhat Mease, Ryan M. Legler, Patricia Bergmann-Leitner, Elke S. Angov, Evelina TI EFFECT OF HISTIDINE AFFINITY TAGS ON PLASMODIUM FALCIPARUM MSP1-42 PROTEIN STRUCTURE AND INDUCTION OF IMMUNITY SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Khan, Farhat; Mease, Ryan M.; Legler, Patricia; Bergmann-Leitner, Elke S.; Angov, Evelina] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Bergmann-Leitner, Elke/B-3548-2011 OI Bergmann-Leitner, Elke/0000-0002-8571-8956 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 938 BP 270 EP 270 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701352 ER PT J AU Carter, J Clayton, J Alexanian, A Angov, E Dutta, S AF Carter, Jennifer Clayton, Joshua Alexanian, Aline Angov, Evelina Dutta, Sheetij TI DEVELOPMENT OF A RECOMBINANT VACCINE BASED ON THE CIRCUMSPOROZOITE PROTEIN (CSP) OF PLASMODIUM FALCIPARUM SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Carter, Jennifer; Clayton, Joshua; Alexanian, Aline; Angov, Evelina; Dutta, Sheetij] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 940 BP 271 EP 271 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701354 ER PT J AU Graf, PC Mundal, KD Lucas, CM Bacon, DJ Espinosa, BJ Alvarado, A Vadivia, RS Campos, LJ Gonzales, RG Olaya, WV Suclupe, EP Ockenhouse, CF Richie, TL Fryauff, DJ AF Graf, Paul C. Mundal, Kirk D. Lucas, Carmen M. Bacon, David J. Espinosa, Benjamin J. Alvarado, Arturo Santillan Vadivia, Rosa Jimenez Campos, Lourdes Garrido Gonzales, Rommel Vegas Olaya, Walter Pozo Suclupe, Edwar Ockenhouse, Chris F. Richie, Thomas L. Fryauff, David J. TI ENTOMOLOGICAL SUPPORT FROM PERU TOWARD DEVELOPMENT OF A SAFE AND REPRODUCIBLE PLASMODIUM VIVAX CHALLENGE SYSTEM IN THE US MILITARY MALARIA VACCINE PROGRAM SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Graf, Paul C.; Mundal, Kirk D.; Lucas, Carmen M.; Bacon, David J.; Espinosa, Benjamin J.] Naval Med Res Ctr Detachment, Lima, Peru. [Alvarado, Arturo; Santillan Vadivia, Rosa; Vegas Olaya, Walter; Pozo Suclupe, Edwar] Sub Reg Hlth Luciano Castillo Colonna, Sullana, Peru. [Jimenez Campos, Lourdes; Garrido Gonzales, Rommel] Bellavista Hlth Ctr, Sullana, Peru. [Ockenhouse, Chris F.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Richie, Thomas L.; Fryauff, David J.] USN, Med Res Ctr, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 942 BP 271 EP 272 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701356 ER PT J AU Takeo, S Sakamoto, H Kaneko, T Tachibana, M Miura, K Varma, S Sattabongkot, J Torii, M Tsuboi, T AF Takeo, Satoru Sakamoto, Hirokazu Kaneko, Takamasa Tachibana, Mayumi Miura, Kazutoyo Varma, Sudhir Sattabongkot, Jetsumon Torii, Motomi Tsuboi, Takafumi TI IDENTIFICATION OF NOVEL BLOOD-STAGE VACCINE CANDIDATES AGAINST PLASMODIUM FALCIPARUM BY HIGH-THROUGHPUT IMMUNOSCREENING SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Takeo, Satoru; Sakamoto, Hirokazu; Kaneko, Takamasa; Tachibana, Mayumi; Torii, Motomi; Tsuboi, Takafumi] Ehime Univ, Matsuyama, Ehime 790, Japan. [Miura, Kazutoyo] NIAID, MVDB, NIH, Rockville, MD USA. [Varma, Sudhir] NIAID, BCBB, NIH, Bethesda, MD 20892 USA. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 944 BP 272 EP 272 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701358 ER PT J AU McKeon, SN Lehr, MA Kilpatrick, CW Wilkerson, RC Salum, MA Pereira, JB Conn, JE AF McKeon, S. N. Lehr, M. A. Kilpatrick, C. W. Wilkerson, R. C. Salum, M. A. Pereira, J. B. Conn, J. E. TI PHYLOGENETIC RELATIONSHIP AND POPULATION STRUCTURE OF THE NEOTROPICAL MALARIA VECTOR ANOPHELES MARAJOARA (DIPTERA: CULICIDAE) USING MULTIPLE MOLECULAR MARKERS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [McKeon, S. N.] SUNY Albany, Sch Publ Hlth, Slingerlands, NY USA. [Lehr, M. A.; Kilpatrick, C. W.] Univ Vermont, Coll Arts & Sci, Burlington, VT USA. [Wilkerson, R. C.] Smithsonian Inst, Walter Reed Army Inst Res, Washington, DC 20560 USA. [Salum, M. A.] Univ Sao Paulo, Fac Saude Publ, Sao Paulo, Brazil. [Pereira, J. B.] Inst Oswaldo Cruz, Lab Fisiol & Controle Artropodes Vetores, BR-20001 Rio De Janeiro, Brazil. [Conn, J. E.] New York State Dept Hlth, Wadsworth Ctr, Griffin Lab, Albany, NY USA. NR 0 TC 0 Z9 0 U1 1 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 963 BP 277 EP 278 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701377 ER PT J AU Wilkerson, RC Spindler, V Sallum, MA Povoa, MM Correa, MM Gutierrez, LA Rangel, Y Conn, JE AF Wilkerson, Richard C. Spindler, Victoria Sallum, Maria Anice Povoa, Marinete M. Correa, Margarita M. Gutierrez, Lina A. Rangel, Yadira Conn, Jan E. TI LINEAGE DIVERGENCE IN THE NEOTROPICAL MALARIA VECTOR ANOPHELES (NYSSORHYNCHUS) NUNEZTOVARI AND ITS SISTER TAXON AN. GOELDII (DIPTERA: CULICIDAE) BASED ON NUCLEAR WHITE AND MTDNA COI SEQUENCE ANALYSIS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Wilkerson, Richard C.] Smithsonian Inst, Walter Reed Army Inst Res, Washington, DC 20560 USA. [Spindler, Victoria] SUNY Albany, Sch Publ Hlth, Albany, NY USA. [Sallum, Maria Anice] Univ Sao Paulo, Fac Saude Publ, Sao Paulo, Brazil. [Povoa, Marinete M.] Inst Evandro Chagas, Programa Pesquisas Malaria, Belem, Para, Brazil. [Correa, Margarita M.; Gutierrez, Lina A.] Univ Antioquia, Escuela Microbiol, Medellin, Colombia. [Rangel, Yadira] Cent Univ Venezuela, Inst Zool Trop, Caracas, Venezuela. [Conn, Jan E.] New York State Dept Hlth, Wadsworth Ctr, Albany, NY USA. RI Sallum, Maria/B-8537-2012 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 965 BP 278 EP 278 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701379 ER PT J AU Foley, DH Wilkerson, RC AF Foley, Desmond H. Wilkerson, Richard C. TI MOSQUITOMAP AND THE MAL-AREA CALCULATOR: NEW WEB RESOURCES FOR GLOBAL MOSQUITO SPECIES DISTRIBUTION AND VECTOR-BORNE DISEASE RISK ASSESSMENT SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Foley, Desmond H.; Wilkerson, Richard C.] Walter Reed Army Inst Res, Suitland, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 968 BP 279 EP 279 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701382 ER PT J AU Shrestha, SK Pavlin, JA Myint, KS Shrestha, BK Gibbons, RV Shrestha, B Hussem, K Rayamajhi, BB Jarman, RG AF Shrestha, Sanjaya K. Pavlin, Julie A. Myint, Khin S. Shrestha, Bishnu K. Gibbons, Robert V. Shrestha, Binob Hussem, Kittinun Rayamajhi, Bishnu B. Jarman, Richard G. TI SENTINEL HUMAN SURVEILLANCE FOR INFLUENZA AT HEALTH CARE FACILITIES IN KATHMANDU SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Shrestha, Sanjaya K.; Shrestha, Bishnu K.; Shrestha, Binob; Rayamajhi, Bishnu B.] Walter Reed AFRIMS Res Unit Nepal, Kathmandu, Nepal. [Pavlin, Julie A.; Myint, Khin S.; Gibbons, Robert V.; Hussem, Kittinun; Jarman, Richard G.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 994 BP 286 EP 286 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701408 ER PT J AU Clark, DV Ismayilov, A Seyidova, E Hajiyeva, A Bakhishova, S Hajiyev, H Nuriyev, T Piraliyev, S Bagirov, S Aslanova, A Lane, A Qasimov, M Hepburn, MJ AF Clark, Danielle V. Ismayilov, Afrail Seyidova, Esmiralda Hajiyeva, Ayten Bakhishova, Sevinj Hajiyev, Huseyn Nuriyev, Tahir Piraliyev, Saleh Bagirov, Sadigulla Aslanova, Afag Lane, Amanda Qasimov, Maqsud Hepburn, Matthew J. TI EMERGING VIRAL ZOONOSES IN AZERBAIJAN: A CROSS-SECTIONAL STUDY SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Clark, Danielle V.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Ismayilov, Afrail; Seyidova, Esmiralda; Bakhishova, Sevinj; Hajiyev, Huseyn; Qasimov, Maqsud] Antiplague Stn, Baku, Azerbaijan. [Hajiyeva, Ayten] Republican Vet Lab, Baku, Azerbaijan. [Nuriyev, Tahir; Piraliyev, Saleh; Bagirov, Sadigulla] Ctr Hyg & Epidemiol, Qusar, Xachmaz, Azerbaijan. [Aslanova, Afag] Raytheon Tech Serv Co, Baku, Azerbaijan. [Lane, Amanda; Hepburn, Matthew J.] USA, Res Inst Infect Dis, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 1001 BP 288 EP 288 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701415 ER PT J AU Aguiar, JC Bolton, J Wanga, J Urquhart, A Sacci, JB Limbach, K Tsuboi, T Ockenhouse, C Richie, TL AF Aguiar, Joao Carlos Bolton, Jessica Wanga, Joyce Urquhart, AnneMarie Sacci, John B. Limbach, Keith Tsuboi, Takafumi Ockenhouse, Chris Richie, Thomas L. TI DISCOVERING NOVEL PRE-ERYTHROCYTIC ANTIGENS FOR MALARIA VACCINES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Aguiar, Joao Carlos; Bolton, Jessica; Wanga, Joyce; Limbach, Keith; Richie, Thomas L.] USN, Med Res Ctr, Silver Spring, MD USA. [Urquhart, AnneMarie; Ockenhouse, Chris] Walter Reed Army Inst Res, Silver Spring, MD USA. [Sacci, John B.] Univ Maryland, Sch Med, Baltimore, MD 21201 USA. [Tsuboi, Takafumi] Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime, Japan. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 1009 BP 290 EP 291 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701423 ER PT J AU Lumsden, J Schwenk, RJ Egner, L Cohen, J Ballou, R Ofori-Anyinam, O Moris, P Kester, KE Heppner, DG Krzych, U AF Lumsden, Joanne Schwenk, Robert J. Egner, Lisa Cohen, Joe Ballou, Ripley Ofori-Anyinam, Opokua Moris, Philippe Kester, Kent E. Heppner, D. Gray Krzych, Urszula TI IL-2-PRODUCING EFFECTOR MEMORY AND CENTRAL MEMORY CD4(+) T CELL SUBSETS ARE ASSOCIATED WITH PROTECTIVE IMMUNITY IN RTS,S-IMMUNIZED SUBJECTS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Lumsden, Joanne; Schwenk, Robert J.; Egner, Lisa; Kester, Kent E.; Heppner, D. Gray; Krzych, Urszula] Walter Reed Army Inst Res, Silver Spring, MD USA. [Cohen, Joe; Ballou, Ripley; Ofori-Anyinam, Opokua; Moris, Philippe] GSK Biol, Rixensart, Belgium. RI Kester, Kent/A-2114-2011; Lumsden, Joanne/B-6475-2009 OI Kester, Kent/0000-0002-5056-0802; NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 1010 BP 291 EP 291 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701424 ER PT J AU Wasserberg, G Poche, R Polyakova, LA Chenault, MV Zollner, G Rowton, ED Miller, D AF Wasserberg, Gideon Poche, Richard Polyakova, Larisa A. Chenault, Michelle V. Zollner, Gabriela Rowton, Edgar D. Miller, David TI FEED-THROUGH CONTROL FOR LARVAL SAND FLIES USING HOST-TARGETED INSECTICIDE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Wasserberg, Gideon; Chenault, Michelle V.; Zollner, Gabriela; Rowton, Edgar D.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Poche, Richard; Polyakova, Larisa A.; Miller, David] Genesis Labs Inc, Wellington, CO USA. RI Zollner, Gabriela/B-6073-2011; Rowton, Edgar/A-1975-2011 OI Rowton, Edgar/0000-0002-1979-1485 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 1016 BP 292 EP 293 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701430 ER PT J AU Vanloubbeeck, Y Pichyangkul, S Bayat, B Yongvanitchit, K Srichairatanakul, U Chluaydumrong, A Donner, MN Garze, V Afsar, A Ware, L Dubois, MC Mettens, P Lemiale, L Polhemus, M House, B Sattabongkot, J Schaecher, K Ockenhouse, C Cohen, J Yadava, A AF Vanloubbeeck, Yannick Pichyangkul, Sathit Bayat, Babak Yongvanitchit, Kosol Srichairatanakul, Utaiwan Chluaydumrong, Amporn Donner, Marie-Noelle Garze, Virginie Afsar, Aram Ware, Lisa Dubois, Marie-Claude Mettens, Pascal Lemiale, Laurence Polhemus, Mark House, Brent Sattabongkot, Jetsumon Schaecher, Kurt Ockenhouse, Christian Cohen, Joe Yadava, Anjali TI INDUCTION OF VACCINE-SPECIFIC T CELL AND ANTIBODY RESPONSES IN RHESUS MACAQUES IMMUNIZED WITH TWO PLASMODIUM VIVAX CIRCUMSPOROZOITE-BASED VACCINE ANTIGEN CANDIDATES FORMULATED IN AS01(B) SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Vanloubbeeck, Yannick; Bayat, Babak; Donner, Marie-Noelle; Garze, Virginie; Afsar, Aram; Dubois, Marie-Claude; Mettens, Pascal; Cohen, Joe] GlaxoSmithKline Biol, Rixensart, Belgium. [Pichyangkul, Sathit; Yongvanitchit, Kosol; Srichairatanakul, Utaiwan; Chluaydumrong, Amporn; Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Ware, Lisa; Polhemus, Mark; House, Brent; Schaecher, Kurt; Ockenhouse, Christian; Yadava, Anjali] Walter Reed Army Inst Res, Silver Spring, MD USA. [Lemiale, Laurence] PATH Malaria Vaccine Initiat, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 1032 BP 297 EP 297 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701446 ER PT J AU Kaba, SA Brando, C Mittelholzer, C Guo, Q McWilliams, I Crisanti, A Spaccapelo, R Burkhard, P Lanar, DE AF Kaba, Stephen A. Brando, Clara Mittelholzer, Christian Guo, Qin McWilliams, Ian Crisanti, Andrea Spaccapelo, Roberta Burkhard, Peter Lanar, David E. TI A NON-ADJUVANTED POLYPEPTIDE NANOPARTICLE VACCINE TARGETING PLASMODIUM FALCIPARUM CSP INDUCES 100% STERILE PROTECTION AGAINST LETHAL CHALLENGE WITH LIVE SPOROZOITES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Kaba, Stephen A.; Brando, Clara; Guo, Qin; McWilliams, Ian; Lanar, David E.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Mittelholzer, Christian] ME Muller Inst, Basel, Switzerland. [Crisanti, Andrea] Univ London Imperial Coll Sci Technol & Med, London, England. [Spaccapelo, Roberta] Univ Perugia, I-06100 Perugia, Italy. [Burkhard, Peter] Univ Connecticut, Storrs, CT USA. RI Kaba, Stephen/B-3555-2011; Lanar, David/B-3560-2011 OI Kaba, Stephen/0000-0003-1509-2975; NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 1034 BP 298 EP 298 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701448 ER PT J AU Dutta, S Dlugosz, L Schwarz, M Clayton, J Foley, M Anders, R Batchelor, A AF Dutta, Sheetij Dlugosz, Lisa Schwarz, Margaret Clayton, Joshua Foley, Michael Anders, Robin Batchelor, Adrian TI DESIGNING A PAN-REACTIVE MALARIA VACCINE BASED ON THE CROSS-REACTIVE EPITOPES OF APICAL MEMBRANE ANTIGEN-1 OF PLASMODIUM FALCIPARUM SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Dutta, Sheetij; Dlugosz, Lisa; Schwarz, Margaret; Clayton, Joshua; Batchelor, Adrian] Walter Reed Army Inst Res, Silver Spring, MD USA. [Foley, Michael; Anders, Robin] La Trobe Univ, Dept Biochem, Bundoora, Vic 3086, Australia. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 1037 BP 299 EP 299 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701451 ER PT J AU Thera, MA Doumbo, OK Coulibaly, D Laurens, MB Kone, A Guindo, A Diallo, DA Traore, K Kouriba, B Diarra, I Dolo, A Niangaly, A Daou, M Sissoko, M Traore, D Lyke, KE Takala, S Godeaux, O Thonnard, J Cohen, J Lanar, D Diggs, C Soisson, L Heppner, DG Plowe, CV AF Thera, Mahamadou A. Doumbo, Ogobara K. Coulibaly, Drissa Laurens, Matthew B. Kone, Abdoulaye Guindo, Ando Diallo, Dapa A. Traore, Karim Kouriba, Bourema Diarra, Issa Dolo, Amagana Niangaly, Amadou Daou, Modibo Sissoko, Mady Traore, Drissa Lyke, Kirsten E. Takala, Shannon Godeaux, Olivier Thonnard, Joelle Cohen, Joe Lanar, David Diggs, Carter Soisson, Lorraine Heppner, Donald G. Plowe, Christopher V. TI RANDOMIZED, CONTROLLED, PHASE 2B CLINICAL TRIAL TO EVALUATE THE SAFETY, IMMUNOGENICITY AND EFFICACY OF WRAIR'S AMA-1 MALARIA VACCINE (FMP2.1) ADJUVANTED IN GSK BIOLOGICALS' AS02A VS. RABIES VACCINE IN 1-6 YEAR OLD CHILDREN IN BANDIAGARA, MALI SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Thera, Mahamadou A.; Doumbo, Ogobara K.; Coulibaly, Drissa; Kone, Abdoulaye; Guindo, Ando; Diallo, Dapa A.; Traore, Karim; Kouriba, Bourema; Diarra, Issa; Dolo, Amagana; Niangaly, Amadou; Daou, Modibo; Sissoko, Mady; Traore, Drissa] Univ Bamako, MRTC DEAP FMPOS, Bamako, Mali. [Laurens, Matthew B.; Lyke, Kirsten E.; Takala, Shannon; Plowe, Christopher V.] Univ Maryland, CVD, Baltimore, MD 21201 USA. [Godeaux, Olivier; Thonnard, Joelle; Cohen, Joe] GlaxoSmithKline Biol, Rixensart, Belgium. [Lanar, David; Heppner, Donald G.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Diggs, Carter; Soisson, Lorraine] US Agcy Int Dev, Washington, DC 20523 USA. RI Lanar, David/B-3560-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 1074 BP 310 EP 310 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701488 ER PT J AU Chuang, I Prachumsri, J Fryauff, D Murphy, J Saunders, D Richardson, J Tosh, D Williams, J Bethell, D Richie, TL Ware, L Spring, M Fukuda, M Tamminga, C Cummings, J Kathcart, A Yadava, A Komisar, J O'Neil, M Polhemus, M Ockenhouse, CF AF Chuang, Ilin Prachumsri, Jetsumon Fryauff, David Murphy, Jitta Saunders, David Richardson, Jason Tosh, Donna Williams, Jack Bethell, Delia Richie, Thomas L. Ware, Lisa Spring, Michele Fukuda, Mark Tamminga, Cindy Cummings, James Kathcart, April Yadava, Anjali Komisar, Jack O'Neil, Mike Polhemus, Mark Ockenhouse, Christian F. TI DEVELOPMENT OF A SAFE AND REPRODUCIBLE HUMAN SPOROZOITE CHALLENGE MODEL FOR PLASMODIUM VIVAX IN HEALTHY ADULTS IN THE UNITED STATES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Chuang, Ilin; Fryauff, David; Richie, Thomas L.; Tamminga, Cindy] USN, Med Res Ctr, Silver Spring, MD USA. [Prachumsri, Jetsumon; Saunders, David; Richardson, Jason; Bethell, Delia; Fukuda, Mark] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Murphy, Jitta; Tosh, Donna; Williams, Jack; Ware, Lisa; Spring, Michele; Cummings, James; Kathcart, April; Yadava, Anjali; Komisar, Jack; O'Neil, Mike; Polhemus, Mark; Ockenhouse, Christian F.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Richardson, Jason/A-9441-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 1079 BP 311 EP 312 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701493 ER PT J AU Tamminga, C Sedegah, M Chuang, I Regis, D Epstein, JE Spring, M Mendoza-Silveiras, J Steinbeiss, V Fedders, C Reyes, S Parekh, F Williams, F Smith, K Maiolatesi, S Doolan, DL Limbach, K Patterson, NB Bruder, J King, CR Soisson, L Diggs, C Ockenhouse, C Richie, TL AF Tamminga, C. Sedegah, M. Chuang, I. Regis, D. Epstein, J. E. Spring, M. Mendoza-Silveiras, J. Steinbeiss, V. Fedders, C. Reyes, S. Parekh, F. Williams, F. Smith, K. Maiolatesi, S. Doolan, D. L. Limbach, K. Patterson, N. B. Bruder, J. King, C. R. Soisson, L. Diggs, C. Ockenhouse, C. Richie, T. L. TI SAFETY, TOLERABILITY, IMMUNOGENICITY AND PROTECTIVE EFFICACY OF AN ADENOVIRUS-VECTORED PLASMODIUM FALCIPARUM MALARIA VACCINE IN HEALTHY, MALARIA-NAIVE ADULTS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Tamminga, C.; Sedegah, M.; Chuang, I.; Regis, D.; Epstein, J. E.; Spring, M.; Mendoza-Silveiras, J.; Steinbeiss, V.; Fedders, C.; Reyes, S.; Parekh, F.; Smith, K.; Maiolatesi, S.; Doolan, D. L.; Limbach, K.; Patterson, N. B.; Ockenhouse, C.; Richie, T. L.] USN, Med Res Ctr, US Mil Malaria Vaccine Program, Walter Reed Army Inst Res, Silver Spring, MD USA. [Williams, F.] Natl Naval Med Ctr, Bethesda, MD USA. [Bruder, J.; King, C. R.] GenVec Inc, Gaithersburg, MD USA. [Soisson, L.; Diggs, C.] US Agcy Int Dev, Washington, DC 20523 USA. RI Doolan, Denise/F-1969-2015 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 1078 BP 311 EP 311 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701492 ER PT J AU Herrera, S Fernandez, O Manzano, MR Murrain, B Vergara, J Blanco, P Palacios, R Velez, JD Epstein, JE Chen-Mok, M Reed, ZH Arevalo-Herrera, M AF Herrera, Socrates Fernandez, Olga Manzano, Maria R. Murrain, Bermans Vergara, Juana Blanco, Pedro Palacios, Ricardo Velez, Juan D. Epstein, Judith E. Chen-Mok, Mario Reed, Zarifah H. Arevalo-Herrera, Myriam TI Case Report: Successful Sporozoite Challenge Model in Human Volunteers with Plasmodium vivax Strain Derived from Human Donors SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID HUMAN MALARIA; FALCIPARUM-MALARIA; ANOPHELES-ALBIMANUS; PROTECTIVE EFFICACY; AOTUS MONKEYS; VACCINE; PROTEIN; MOSQUITOS; IMMUNOGENICITY; EXPRESSION AB Successful establishment of a Plasmodium vivax sporozoite challenge model in humans is described. Eighteen healthy adult, malaria-naive volunteers were randomly allocated to Groups A-C and exposed to 3 +/- 1, 6 +/- 1, and 9 +/- 1 bites of Anopheles albimanus mosquitoes infected with P vivax, respectively. Seventeen volunteers developed signs and symptoms consistent with malaria, and geometric mean prepatent periods of 11.1 days (9.3-11) for Group A; 10.8 days (9.8-11.9) for Group B; and 10.6 days (8.7-12.4) for Group C, with no statistically significant difference among groups (Kruskal-Wallis, P = 0.70). One volunteer exposed to eight mosquito bites did not develop a parasitemia. No differences in parasite density were observed and all individuals successfully recovered after anti-malarial treatment. None of the volunteers developed parasite relapses within an 18-month follow-up. In conclusion, malaria-naive volunteers can be safely and reproducibly infected with bites of 2-10 An. albimanus mosquitoes carrying P vivax. sporozoites. This challenge method is suitable for vaccine and anti-malarial drug testing. C1 [Herrera, Socrates; Fernandez, Olga; Murrain, Bermans; Vergara, Juana; Blanco, Pedro; Arevalo-Herrera, Myriam] Ctr Int Vacunas, Cali 26020, Colombia. [Herrera, Socrates; Fernandez, Olga; Murrain, Bermans; Vergara, Juana; Blanco, Pedro; Arevalo-Herrera, Myriam] Univ Valle, Fac Salud, Inst Inmunol, Cali 25574, Colombia. [Manzano, Maria R.] Univ Nacl Colombia, Dept Ciencias Agr, Palmira 2253, Colombia. [Palacios, Ricardo] Univ Fed Sao Paulo, Div Infect Dis, BR-04002400 Sao Paulo, Brazil. [Velez, Juan D.] Fdn Clin Valle Lili, Cali 020338, Colombia. [Epstein, Judith E.] USN, US Mil Malaria Vaccine Program, Med Res Ctr, Walter Reed Army Inst Res, Silver Spring, MD USA. USN, Malaria Program, Med Res Ctr, Silver Spring, MD USA. [Chen-Mok, Mario] Family Hlth Int, Durham, NC 27713 USA. [Reed, Zarifah H.] Reg Emerging Dis Intervent REDI Ctr, Singapore 138670, Singapore. WHO, Initiat Vaccine Res, CH-1211 Geneva, Switzerland. RP Herrera, S (reprint author), Ctr Int Vacunas, Cali 26020, Colombia. EM sherrera@inmuno.org; olgalufe@yahoo.com; mrmanzano@palmira.unal.edu.co; ber_mansmurrain@yahoo.com; jvergara@inmuno.org; pblancot@gmail.com; ricardopalacios@gmx.net; jdvelez@telesat.com.co; mchen@fhi.org; zareed@redi.org.sg; marevalo@inmuno.org RI Manzano, Maria/D-3955-2011; OI Manzano, Maria/0000-0002-0858-2426 FU World Health Organization Initiative for Vaccine Research [LA35735G]; National Institute of Allergy and Infectious Diseases NIAID [AI49486-05/TMRC]; Colombian National Research Council; COLCIENCIAS; Malaria Vaccine and Drug Development Center Foundation FX This work was supported by World Health Organization Initiative for Vaccine Research (grant no. LA35735G), National Institute of Allergy and Infectious Diseases (NIAID grant no. AI49486-05/TMRC), Colombian National Research Council, COLCIENCIAS, and the Malaria Vaccine and Drug Development Center Foundation. The contribution of U.S. Navy staff was supported by Work Unit Number 6000.RAD1.F.A309. NR 26 TC 23 Z9 24 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 BP 740 EP 746 DI 10.4269/ajtmh.2009.09-0194 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WI UT WOS:000271956500003 PM 19861603 ER PT J AU Bai, Y Kosoy, MY Lerdthusnee, K Peruski, LF Richardson, JH AF Bai, Ying Kosoy, Michael Y. Lerdthusnee, Kriangkrai Peruski, Leonard F. Richardson, Jason H. TI Prevalence and Genetic Heterogeneity of Bartonella Strains Cultured from Rodents from 17 Provinces in Thailand SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID SP-NOV; SOUTHERN CHINA; DIVERSITY; GRAHAMII; PATIENT; TAYLORII; MAMMALS; RATTUS; FLEAS; RATS AB To study the distribution and diversity of Bartonella in rodents from Thailand, 330 rodents belonging to 13 species were tested. The majority (80.6%) of rodents examined belonged to the genus Rattus. Bartonellae were Cultured from 41.5% of the rodents with a wide range of prevalence by host species and regions. Sequencing of gltA revealed diverse Bartonella strains. Bartonellae from Rattus spp. belonged to 23 variants and clustered with Bartonella coopersplainensis, Bartonella elizabethae, Bartonella phoceensis, Bartonella rattimassiliensis, Bartonella tribocorum, and all unknown geno-group. Bartonellae from Bandicota spp. belonged to six variants and clustered with B. coopersplainensis, B. rattimassilliensis, and B. tribocorum. Three variants from Mus spp. clustered with B. coopersplainensis or B. rattimassilliensis. The only isolate from a Berylmys berdmorei fell into the B. tribocorum group. The observations highlight the need to study these agents for their role in human febrile illnesses of unknown etiology in Thailand and elsewhere in Asia. C1 [Bai, Ying; Kosoy, Michael Y.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80522 USA. [Lerdthusnee, Kriangkrai; Richardson, Jason H.] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Peruski, Leonard F.] Thai MOPH US CDC Collaborat, Int Emerging Infect Program, Bangkok 11000, Thailand. RP Bai, Y (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80522 USA. EM bby5@cdc.gov RI Richardson, Jason/A-9441-2011 NR 23 TC 30 Z9 32 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 BP 811 EP 816 DI 10.4269/ajtmh.2009.09-0294 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WI UT WOS:000271956500016 PM 19861616 ER PT J AU Thomas, SJ Nisalak, A Anderson, KB Libraty, DH Kalayanarooj, S Vaughn, DW Putnak, R Gibbons, RV Jarman, R Endy, TP AF Thomas, Stephen J. Nisalak, Ananda Anderson, Kathryn B. Libraty, Daniel H. Kalayanarooj, Siripen Vaughn, David W. Putnak, Robert Gibbons, Robert V. Jarman, Richard Endy, Timothy P. TI Dengue Plaque Reduction Neutralization Test (PRNT) in Primary and Secondary Dengue Virus Infections: How Alterations in Assay Conditions Impact Performance SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID ARTHROPOD-BORNE VIRUSES; PRIMARY-SCHOOL CHILDREN; HEMORRHAGIC-FEVER; ANTIBODY-RESPONSE; KAMPHAENG PHET; MICRO METHODS; THAILAND; IMMUNOGENICITY; VACCINES; CULTURES AB Dengue virus (DENV) infection is a worsening global health problem. The plaque reduction neutralization test (PRNT) is currently considered to be the "gold standard" to characterize and quantify circulating levels of anti-DENV neutralizing antibody (NAb). Many variations of the PRNT are currently in use and neither the assay nor its performance conditions have been standardized or harmonized between laboratories. We used a well-characterized panel of acute and late convalescent follow-up sera samples from children experiencing primary and secondary DENV infections to evaluate the performance of the dengue PRNT under a variety of testing conditions. Investigators varied cell type, control virus passage, and the use of complement across multiple assay runs of the same sample panel. Our findings indicate wide variation in PRNT titer results in response to varied testing conditions. C1 [Thomas, Stephen J.; Gibbons, Robert V.; Jarman, Richard] USA Med Component, Dept Virol, AFRIMS, APO, AP 96546 USA. Armed Forces Res Inst Med Sci, US Army Med Component, Dept Virol, Bangkok 10400, Thailand. [Anderson, Kathryn B.] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30030 USA. Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA 01655 USA. [Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Dept Pediat, Bangkok 10400, Thailand. [Vaughn, David W.] GlaxoSmithKline Biol, King Of Prussia, PA 19406 USA. [Putnak, Robert] Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD 20910 USA. [Endy, Timothy P.] Upstate Med Univ, SUNY Syracuse, Div Infect Dis, Dept Med, Syracuse, NY 13210 USA. RP Thomas, SJ (reprint author), USA Med Component, Dept Virol, AFRIMS, APO, AP 96546 USA. EM Stephen.thomas@afrims.org; anandan@afrims.org; kbander@learnlink.emory.edu; daniel.libraty@umassmed.edu; siripenk@gmail.com; david.w.vaughn@gsk.com; robert.putnak@us.army.mil; robert.gibbons@afrims.org; richard.jarmnan@afrims.org; endyt@upstate.edu FU United States Army Military Infectious Diseases Research Program (Fort Detrick, Frederick, NID); NIH [P01A134533] FX This work was funded by the United States Army Military Infectious Diseases Research Program (Fort Detrick, Frederick, NID) and NIH grant P01A134533. NR 39 TC 69 Z9 74 U1 0 U2 8 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 BP 825 EP 833 DI 10.4269/ajtmh.2009.08-0625 PG 9 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WI UT WOS:000271956500018 PM 19861618 ER PT J AU Drusano, GL Okusanya, OO Okusanya, AO van Scoy, B Brown, DL Fregeau, C Kulawy, R Kinzig, M Sorgel, F Heine, HS Louie, A AF Drusano, G. L. Okusanya, O. O. Okusanya, A. O. van Scoy, B. Brown, D. L. Fregeau, C. Kulawy, R. Kinzig, M. Soergel, F. Heine, H. S. Louie, A. TI Impact of Spore Biology on the Rate of Kill and Suppression of Resistance in Bacillus anthracis SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID THERAPY; GROWTH; PLAGUE; MODEL AB Bacillus anthracis is complex because of its spore form. The spore is invulnerable to antibiotic action. It also has an impact on the emergence of resistance. We employed the hollow-fiber infection model to study the impacts of different doses and schedules of moxifloxacin on the total-organism population, the spore population, and the subpopulations of vegetative- and spore-phase organisms that were resistant to moxifloxacin. We then generated a mathematical model of the impact of moxifloxacin, administered by continuous infusion or once daily, on vegetative- and spore-phase organisms. The ratio of the rate constant for vegetative- phase cells going to spore phase (K-vs) to the rate constant for spore-phase cells going to vegetative phase (K-sv) determines the rate of organism clearance. The continuous-infusion drug profile is more easily sensed as a threat; the K-vs/K-sv ratio increases at lower drug exposures (possibly related to quorum sensing). This movement to spore phase protects the organism but makes the emergence of resistance less likely. Suppression of resistance requires a higher level of drug exposure with once-daily administration than with a continuous infusion, a difference that is related to vegetative-to-spore (and back) transitioning. Spore biology has a major impact on drug therapy and resistance suppression. These findings explain why all drugs of different classes have approximately the same rate of organism clearance for Bacillus anthracis. C1 [Drusano, G. L.; Okusanya, O. O.; Okusanya, A. O.] Ordway Res Inst, Inst Clin Pharmacodynam, Albany, NY 12208 USA. [Kinzig, M.; Soergel, F.] IBMP Inst Biomed & Pharmaceut Res, Nurnberg, Germany. [Soergel, F.] Univ Duisburg Essen, Dept Pharmacol, Essen, Germany. [Heine, H. S.] USA, Res Inst Infect Dis, Ft Detrick, MD USA. RP Drusano, GL (reprint author), Ordway Res Inst, Inst Clin Pharmacodynam, 150 New Scotland Ave, Albany, NY 12208 USA. EM gdrusano@ordwayresearch.org FU NIAID [P01AI060908] FX This work was supported by P01AI060908, a grant from NIAID to the Emerging Infections and Pharmacodynamics Laboratory. The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Allergy and Infectious Diseases or the National Institutes of Health.; We have no conflicts to disclose. NR 9 TC 4 Z9 4 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD NOV PY 2009 VL 53 IS 11 BP 4718 EP 4725 DI 10.1128/AAC.00802-09 PG 8 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 507US UT WOS:000270881200019 PM 19687233 ER PT J AU Cole, B Lei, J DiLazaro, T Schilling, B Goldberg, L AF Cole, Brian Lei, Jonathan DiLazaro, Tom Schilling, Bradley Goldberg, Lew TI Optical triggering of a Q-switched Nd:YAG laser via transverse bleaching of a Cr:YAG saturable absorber SO APPLIED OPTICS LA English DT Article ID SOLID-STATE LASER; ND-YAG LASER; TIMING JITTER; CR4+YAG; ABSORPTION; REDUCTION AB Optical triggering via direct bleaching of a Cr:YAG saturable absorber was applied to a monolithic Nd:YAG/Cr:YAG laser crystal. The method uses a single laser diode bar to bleach a thin sheet within the saturable absorber from a direction orthogonal to the lasing axis. By placing the Q-switch at the time corresponding to the steepest slope (dT/dt) for change in transmission during bleaching, the pulse-topulse timing jitter showed a 13.2x reduction in standard deviation, from 132 ns for free-running operation to 10 ns with optical triggering. We measured that a fluence of 60 kW/cm(2) was sufficient to enable optical triggering, where a diode appropriately sized for the length of the Cr: YAG (similar to 3 mm) would then require only similar to 150 W of optical power over a 1-2 mu s duration to enable effective jitter reduction. Additionally, we measured an increase in optical-to-optical efficiency with optical triggering, where the efficiency improved from 12% to 13.5%. (C) 2009 Optical Society of America C1 [Cole, Brian; Lei, Jonathan; DiLazaro, Tom; Schilling, Bradley; Goldberg, Lew] USA, RDECOM, CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Cole, B (reprint author), USA, RDECOM, CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. EM info@nvl.army.mil NR 16 TC 7 Z9 7 U1 2 U2 11 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD NOV 1 PY 2009 VL 48 IS 31 BP 6008 EP 6014 DI 10.1364/AO.48.006008 PG 7 WC Optics SC Optics GA 514DH UT WOS:000271374000042 PM 19881668 ER PT J AU Sun, WB Pan, HY Videen, G AF Sun, Wenbo Pan, Huiying Videen, Gorden TI General finite-difference time-domain solution of an arbitrary electromagnetic source interaction with an arbitrary dielectric surface SO APPLIED OPTICS LA English DT Article ID DISCRETE-DIPOLE APPROXIMATION; PERFECTLY MATCHED LAYER; ABSORBING BOUNDARY-CONDITION; LIGHT-SCATTERING; PLANE SURFACE; OPTICAL-PROPERTIES; ROUGH SURFACES; WAVE SCATTERING; PARTICLES; SPHERE AB In this study, we develop a numerical algorithm to calculate the interaction of an arbitrary electromagnetic beam with an arbitrary dielectric surface as one of the tools necessary to design and build a detector network based on surface-enhanced Raman scattering (SERS). By using the scattered-field finite-difference time-domain (FDTD) method with incident source terms in the FDTD equations, this development enables an arbitrary incident beam to be implemented onto an arbitrary dielectric surface or particle. Most importantly, in this study a scattered-field uniaxial perfectly matched layer (SF-UPML) absorbing boundary condition (ABC) is developed to truncate the computational domain of the scattered-field FDTD grid. The novel SF-UPML for the scattered-field FDTD algorithm should have a numerical accuracy similar to that of the conventional uniaxial perfectly matched layer for the source-free FDTD equations. Using the new ABC, the scattered-field FDTD method can accurately calculate electromagnetic wave scattering by an arbitrary dielectric surface or particles illuminated by an arbitrary incident beam. (C) 2009 Optical Society of America C1 [Sun, Wenbo] Sci Syst & Applicat Inc, Hampton, VA 23666 USA. [Pan, Huiying] Calightech Opt Solut, Yorktown, VA 23693 USA. [Videen, Gorden] USA, Res Lab, Adelphi, MD 20783 USA. RP Sun, WB (reprint author), Sci Syst & Applicat Inc, Hampton, VA 23666 USA. EM wenb.sun-1@nasa.gov FU U. S. Army Research Laboratory (USARL) [TCN09044] FX This work is supported by U. S. Army Research Laboratory (USARL) grant TCN09044. NR 66 TC 7 Z9 7 U1 1 U2 8 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD NOV 1 PY 2009 VL 48 IS 31 BP 6015 EP 6025 DI 10.1364/AO.48.006015 PG 11 WC Optics SC Optics GA 514DH UT WOS:000271374000043 PM 19881669 ER PT J AU Fleischman, Z Munasinghe, C Steckl, AJ Wakahara, A Zavada, J Dierolf, V AF Fleischman, Z. Munasinghe, C. Steckl, A. J. Wakahara, A. Zavada, J. Dierolf, V. TI Excitation pathways and efficiency of Eu ions in GaN by site-selective spectroscopy SO APPLIED PHYSICS B-LASERS AND OPTICS LA English DT Article ID MULTIPLE ER3+ SITES; DOPED GAN; IMPLANTED GAN; ELECTROLUMINESCENT DEVICES; YELLOW LUMINESCENCE; EPITAXIAL-FILMS; PHOTOLUMINESCENCE; TEMPERATURE; GROWTH AB Using combined excitation emission spectroscopy, we performed a comparative study of europium ions in GaN in samples that have been in situ doped during interrupted growth epitaxy (IGE) or conventional molecular beam epitaxy (MBE) as well as samples that were grown using organometallic vapor phase epitaxy (OMVPE) and subsequently ion implanted with Eu ions. Through site-selective resonant excitation, we are able to unambiguously assign all major observed transitions to a combination of different incorporation sites and electron-phonon coupled transitions. We identified at least nine different incorporation sites of Eu ions in GaN and studied how these sites behave under different excitation conditions and how their relative number is modified by different growth and doping conditions. The coupling to phonons has also been studied for a series of Al (x) Ga(1-x) N samples with x=0aEuro broken vertical bar 1. We find that a main site most resembling an unperturbed Eu ion on Ga site is always dominant, while the minority sites are changing substantially in relative numbers and can occur in some samples fairly close in emission intensity to the main site. In terms of the excitation pathway after the creation of electron-hole pairs, we found three types of centers: (1) sites that are dominantly excited through shallow defect traps; (2) sites that are excited through a deep defect trap; (3) sites that cannot be excited at all including the majority of the main sites. We interpret this finding to indicate that the ion in this environment is not very efficient in trapping excitation and that the indirect excitation involving other traps depends on the ion/trap distance. Many of the main sites are far away from these traps and cannot be excited through this channel at all. The efficiency of excitation is highest for the deep traps, indicating that it would be desirable to enrich the respective site, as has been done with some success in the IGE grown samples. C1 [Fleischman, Z.; Dierolf, V.] Lehigh Univ, Dept Phys, Bethlehem, PA 18015 USA. [Munasinghe, C.; Steckl, A. J.] Univ Cincinnati, Nanoelect Lab, Cincinnati, OH 45221 USA. [Wakahara, A.] Toyohashi Univ Technol, Dept Elect & Elect Engn, Tempaku Ku, Toyohashi, Aichi 4418580, Japan. [Zavada, J.] USA, Res Off, Durham, NC 27709 USA. RP Dierolf, V (reprint author), Lehigh Univ, Dept Phys, Bldg 16, Bethlehem, PA 18015 USA. EM vod2@lehigh.edu OI Steckl, Andrew/0000-0002-1868-4442 FU NSF [DMR NSF-DMR-0705217]; Army Research Lab and Lehigh University [W911NF-07-2-0064]; U. S. Army Research Office [W911NF-06-1-0296] FX The Lehigh part of this work has been supported by an NSF grant (DMR NSF-DMR-0705217), and collaborative agreement W911NF-07-2-0064 between the Army Research Lab and Lehigh University. The Cincinnati work was supported by a grant from the U. S. Army Research Office (W911NF-06-1-0296). NR 31 TC 28 Z9 28 U1 1 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0946-2171 J9 APPL PHYS B-LASERS O JI Appl. Phys. B-Lasers Opt. PD NOV PY 2009 VL 97 IS 3 BP 607 EP 618 DI 10.1007/s00340-009-3605-x PG 12 WC Optics; Physics, Applied SC Optics; Physics GA 512OZ UT WOS:000271260900010 ER PT J AU Brooke, H Bronk, BV McCutcheon, JN Morgan, SL Myrick, ML AF Brooke, Heather Bronk, B. V. McCutcheon, J. N. Morgan, S. L. Myrick, M. L. TI A Study of Electric Field Standing Waves on Reflection Microspectroscopy of Polystyrene Particles SO APPLIED SPECTROSCOPY LA English DT Article DE Infrared spectroscopy; Infrared microspectroscopy; Reflectance; Refractive index; Optical constants; Particles; Scattering; Electric field standing waves; EFSW ID LIGHT-SCATTERING; SPHERE; FILMS; FABRICATION; SPECTRA; SURFACE AB We have been investigating the mid-infrared (MIR) reflection spectrum of microparticles on mirrored substrates. Gold-coated porous alumina filters were used as a substrate to layer the particles and provide consistent reflection spectra. Polystyrene spheres with measured diameters of 0.42 pm were studied using Fourier transform infrared (FT-IR) reflection microspectroscopy, and spectra are shown for coverages in the range 0.5-6 monolayers (ML). Results show that absorption has a nonlinear, stair-step-like dependence on particle coverage and a wavelength dependence that can be explained by electric field standing waves (EFSW) caused by the mirrored substrate. The same effect is found to cause progressive weakening of the observed spectra as a function of increasing wavelength in sub-monolayer coverage measurements. Scattering effects in the spectra are consistent with surface scattering at the antinodes of the EFSW These observations provide explanations for differences seen between optical properties of particles calculated using the specular-reflection method versus those calculated using traditional aerosol methods. A simple multilayer method for estimating particle absorption coefficients is demonstrated that compares well with values reported using ellipsometry for bulk polystyrene. Another simple method based on sub-monolayer coverage spectra provides spectra suitable for classification analysis but is only semi-quantitative at determining absorption coefficients. C1 [Brooke, Heather; McCutcheon, J. N.; Morgan, S. L.; Myrick, M. L.] Univ S Carolina, Dept Chem & Biochem, Columbia, SC 29208 USA. [Bronk, B. V.] USAF, Res Lab, Wright Patterson AFB, OH 45433 USA. [Bronk, B. V.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Myrick, ML (reprint author), Univ S Carolina, Dept Chem & Biochem, Columbia, SC 29208 USA. EM myrick@mail.chem.sc.edu OI Myrick, Michael/0000-0002-6905-0925 FU National Institutes of Justice [2007-DN-BX-K199] FX The authors acknowledge support in the writing of this report from the National Institutes of Justice under grant 2007-DN-BX-K199. The authors are also indebted to Professor Glenn Boreman (University of Central Florida) and Dr. William Folks for providing the detailed electronic file of results for polystyrene shown in graphical format as Fig. 3 in Ref. 27. The authors would like to acknowledge the University of South Carolina Electron Microscopy Center for instrument use and scientific and technical assistance. H.B. thanks the Graduate School of the University of South Carolina (Columbia) for travel and other support during this project. NR 32 TC 10 Z9 10 U1 0 U2 12 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA 201B BROADWAY ST, FREDERICK, MD 21701 USA SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD NOV PY 2009 VL 63 IS 11 BP 1293 EP 1302 PG 10 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA 521NU UT WOS:000271929400014 PM 19891839 ER PT J AU Lai, HG Feng, MH Roxas-Duncan, V Dakshanamurthy, S Smith, LA Yang, DCH AF Lai, Huiguo Feng, Minghao Roxas-Duncan, Virginia Dakshanamurthy, Sivanesan Smith, Leonard A. Yang, David C. H. TI Quinolinol and peptide inhibitors of zinc protease in botulinum neurotoxin A: Effects of zinc ion and peptides on inhibition SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS LA English DT Article DE Zinc protease; Inhibitor; Quinolinol; Peptide; Botulinum; Neurotoxin; Slow binding; Tight binding; Molecular modeling; Fluorescence titration ID SMALL-MOLECULE INHIBITORS; CATION-PI INTERACTIONS; LIGHT-CHAIN; SUBSTRATE RECOGNITION; CRYSTAL-STRUCTURE; SEROTYPE-A; ESCHERICHIA-COLI; TRANSFER-RNA; DOCKING; BINDING AB Quinolinol derivatives were found to be effective inhibitors of botulinum neurotoxin serotype A (BoNT/A). Studies of the inhibition and binding of 7-(phenyl(8-quinolinylamino)methyl)-8-quinolinol (QAQ) to the light chain domain (BoNT/A LC) showed that QAQ is a non-competitive inhibitor for the zinc protease activity. Binding and molecular modeling studies reveal that QAQ binds to a hydrophobic pocket near the active site. Its inhibitor effect does not involve the removal of zinc ion from the light chain. A 24-mer SNAP-25 peptide containing E183 to G206 with Q197C mutation (Peptide C) binds to BoNT/A LC with an unusually slow second order binding rate constant of 76.7 M(-1) s(-1). QAQ binds to Zn(2+)-free BoNT/A LC with a K(D) of 0.67 mu M and to Peptide C-BoNT/A LC complex with a K(D) of 2.33 mu M. The insights of the interactions of quinolinols and peptides with the zinc protease of BoNT/A should aid in the development of inhibitors of metalloproteases. (C) 2009 Elsevier Inc. All rights reserved. C1 [Lai, Huiguo; Feng, Minghao; Yang, David C. H.] Georgetown Univ, Dept Chem, Washington, DC 20057 USA. [Roxas-Duncan, Virginia; Smith, Leonard A.] USA, Med Res Inst Infect Dis, Integrated Toxiol Div, Ft Detrick, MD 21702 USA. [Dakshanamurthy, Sivanesan] Georgetown Univ, Lombardi Canc Ctr, Washington, DC 20057 USA. RP Yang, DCH (reprint author), Georgetown Univ, Dept Chem, Washington, DC 20057 USA. EM yangdc@georgetown.edu RI Yang, David/A-7294-2009 NR 32 TC 19 Z9 20 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0003-9861 J9 ARCH BIOCHEM BIOPHYS JI Arch. Biochem. Biophys. PD NOV PY 2009 VL 491 IS 1-2 BP 75 EP 84 DI 10.1016/j.abb.2009.09.008 PG 10 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 518DC UT WOS:000271669500011 PM 19772855 ER PT J AU Crothers, BA Tench, WD Schwartz, MR Bentz, JS Moriarty, AT Clayton, AC Fatheree, LA Chmara, BA Wilbur, DC AF Crothers, Barbara A. Tench, William D. Schwartz, Mary R. Bentz, Joel S. Moriarty, Ann T. Clayton, Amy C. Fatheree, Lisa A. Chmara, Beth Anne Wilbur, David C. TI Guidelines for the Reporting of Nongynecologic Cytopathology Specimens SO ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE LA English DT Article ID OF-AMERICAN-PATHOLOGISTS; SURGICAL PATHOLOGY; IMPROVE COMMUNICATION; PAPANICOLAOU SOCIETY; CANCER; STANDARDIZATION; RECOMMENDATIONS; CYTOLOGY; BREAST; IMMUNOHISTOCHEMISTRY AB Context.-Gynecologic cytology terminology and report formatting have been nationally standardized since the implementation of The Bethesda System of 1988, but standard reporting for nongynecologic cytology has never been formally addressed on the same scale. Objectives.-To promote patient safety through uniform reporting in nongynecologic cytology (including fine-needle aspiration cytology) and to improve communication between laboratories and health care providers. Data Sources.-Sources include the College of American Pathologists Cytopathology Resource Committee; the College of American Pathologists Council on Scientific Affairs Ad Hoc Committee on Pathology Report Standardization; the College of American Pathologists Laboratory Accreditation Program inspection checklists; the Joint Commission for Accreditation of Healthcare Organizations; and the Clinical Laboratory Improvement Amendments of 1988. Conclusions.-We describe the major elements of quality nongynecologic cytology reporting and discuss areas of controversy in cytology reporting. Standardized nongynecologic specimen reporting will expand the concept of common report elements already widely implemented in gynecologic cytology reporting. The intent is to improve communication with the health care team while remaining in compliance with federal mandates and accreditation guidelines. (Arch Pathol Lab Med. 2009; 133: 1743-1756) C1 [Crothers, Barbara A.] Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. [Crothers, Barbara A.] Walter Reed Army Med Ctr, Area Lab Serv, Washington, DC 20307 USA. [Tench, William D.] Palomar Med Ctr Lab, Escondido, CA USA. [Schwartz, Mary R.] Methodist Hosp, Dept Pathol, Houston, TX 77030 USA. [Bentz, Joel S.] Univ Utah, Dept Pathol, Salt Lake City, UT USA. [Moriarty, Ann T.] AmeriPath Indiana, Dept Pathol, Indianapolis, IN USA. [Clayton, Amy C.] Mayo Clin, Dept Anat Pathol, Rochester, MN USA. [Fatheree, Lisa A.; Chmara, Beth Anne] Coll Amer Pathologists, Dept Cytol Surveys, Northfield, IL USA. [Wilbur, David C.] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA. RP Crothers, BA (reprint author), Walter Reed Army Med Ctr, Dept Pathol, MCHL UAP Ward 47,6900 Georgia Ave NW, Washington, DC 20307 USA. EM barbara.crothers@us.army.mil NR 43 TC 6 Z9 6 U1 0 U2 0 PU COLLEGE AMER PATHOLOGISTS PI NORTHFIELD PA C/O KIMBERLY GACKI, 325 WAUKEGAN RD, NORTHFIELD, IL 60093-2750 USA SN 0003-9985 J9 ARCH PATHOL LAB MED JI Arch. Pathol. Lab. Med. PD NOV PY 2009 VL 133 IS 11 BP 1743 EP 1756 PG 14 WC Medical Laboratory Technology; Medicine, Research & Experimental; Pathology SC Medical Laboratory Technology; Research & Experimental Medicine; Pathology GA 520WP UT WOS:000271880500002 PM 19886707 ER PT J AU Moriarty, AT Crothers, BA Bentz, JS Souers, RJ Fatheree, LA Wilbur, DC AF Moriarty, Ann T. Crothers, Barbara A. Bentz, Joel S. Souers, Rhona J. Fatheree, Lisa A. Wilbur, David C. TI Automatic Failure in Gynecologic Cytology Proficiency Testing Results From the College of American Pathologists Proficiency Testing Program SO ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE LA English DT Article ID INTERLABORATORY COMPARISON PROGRAM; SQUAMOUS INTRAEPITHELIAL LESION; CERVICOVAGINAL CYTOLOGY; VALIDATION CRITERIA; FEATURES; SLIDES; WELL AB Context.-Automatic failure in gynecologic cytology proficiency testing occurs when a high-grade lesion or carcinoma (HSIL+, Category D) is misinterpreted as negative for intraepithelial lesion or malignancy (Category B). Objectives.-To document the automatic failure rate in 2006 and 2007 from the College of American Pathologists proficiency testing program (PAP PT) and compare them to projected values from 2004. Design.-Identify automatic failures from PAP PT in 2006 and 2007 and compare the rates of failure regarding participant and preparation type to validated slides in the College of American Pathologists Interlaboratory Comparison Program in 2004. Results.-There were 65 264 participant responses for HSIL+ slides included in this analysis from 2006 and 2007. Overall, 1% (666 of 65 264) of the HSIL+ responses were classified as negative, resulting in automatic failure for the participant. There were significantly fewer automatic failures in 2007 as compared with either 2006 or projected from 2004 data (P<.001). Conventional preparations had a lower automatic failure rate than liquid-based preparations but only for 2006. Both pathologists and cytotechnologists interpreting liquid-based preparations faired better than projected from 2004 data. Conclusions.-The automatic failure rate in PAP PT is lower than expected based on 2004 data from the College of American Pathologists Interlaboratory Comparison Program. Automatic failures are a relatively small component (1% or less) of proficiency testing failures. The rate of automatic failure decreased from 2006 to 2007 and may be due to loss of poor performers in the testing pool, the test-taking environment, or removal of less robust slides from the program. (Arch Pathol Lab Med. 2009; 133: 1757-1760) C1 [Moriarty, Ann T.] AmeriPath Indiana, Dept Pathol, Indianapolis, IN 46219 USA. [Crothers, Barbara A.] Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. [Crothers, Barbara A.] Walter Reed Army Med Ctr, Area Lab Serv, Washington, DC 20307 USA. [Bentz, Joel S.] Univ Utah, Dept Pathol, Salt Lake City, UT USA. [Souers, Rhona J.] Coll Amer Pathologists, Dept Stat, Northfield, IL USA. [Wilbur, David C.] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA. RP Moriarty, AT (reprint author), AmeriPath Indiana, Dept Pathol, 2560 N Shadeland Ave,Suite A, Indianapolis, IN 46219 USA. EM amoriarty@ameripath.com NR 13 TC 3 Z9 3 U1 0 U2 0 PU COLLEGE AMER PATHOLOGISTS PI NORTHFIELD PA C/O KIMBERLY GACKI, 325 WAUKEGAN RD, NORTHFIELD, IL 60093-2750 USA SN 0003-9985 J9 ARCH PATHOL LAB MED JI Arch. Pathol. Lab. Med. PD NOV PY 2009 VL 133 IS 11 BP 1757 EP 1760 PG 4 WC Medical Laboratory Technology; Medicine, Research & Experimental; Pathology SC Medical Laboratory Technology; Research & Experimental Medicine; Pathology GA 520WP UT WOS:000271880500003 PM 19886708 ER PT J AU Huber, AR Shikle, JF AF Huber, Aaron R. Shikle, James F. TI Benign Fibroblastic Polyps of the Colon SO ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE LA English DT Review ID GASTROINTESTINAL STROMAL TUMORS; PERINEURIOMA; MUCOSAL; RECTUM AB Benign fibroblastic polyps of the colon are a recently described entity among mucosal polyps found in the colorectum. These polyps are typically discovered on routine screening colonoscopy within the distal colon. Benign fibroblastic polyps occur most commonly in adult women in the sixth decade of life. Histologically, benign fibroblastic polyps are bland spindle cell lesions that fill the lamina propria and displace the surrounding crypts. The spindle cell proliferation lacks atypia and significant mitotic activity. Hyperplastic changes are frequently present both in the adjacent epithelium and within the lesions. Immunohistochemically, the cells of benign fibroblastic polyps are invariably positive for vimentin with rare focal positivity for CD34 and smooth muscle actin. They are negative for CD117 and S100 protein. Ultrastructurally, benign fibroblastic polyps have features of fibroblastic differentiation. These polyps are benign with no reports, to our knowledge, of recurrence or metastasis. (Arch Pathol Lab Med. 2009; 133: 1872-1876) C1 [Shikle, James F.] Eisenhower Army Med Ctr, Dept Pathol, Ft Gordon, GA 30905 USA. [Huber, Aaron R.] USN, Med Ctr, Dept Pathol, San Diego, CA 92152 USA. RP Shikle, JF (reprint author), Eisenhower Army Med Ctr, Dept Pathol, 300 Hosp Rd, Ft Gordon, GA 30905 USA. EM jfshikle@yahoo.com NR 15 TC 4 Z9 7 U1 0 U2 1 PU COLLEGE AMER PATHOLOGISTS PI NORTHFIELD PA C/O KIMBERLY GACKI, 325 WAUKEGAN RD, NORTHFIELD, IL 60093-2750 USA SN 0003-9985 J9 ARCH PATHOL LAB MED JI Arch. Pathol. Lab. Med. PD NOV PY 2009 VL 133 IS 11 BP 1872 EP 1876 PG 5 WC Medical Laboratory Technology; Medicine, Research & Experimental; Pathology SC Medical Laboratory Technology; Research & Experimental Medicine; Pathology GA 520WP UT WOS:000271880500022 PM 19886727 ER PT J AU Goldman, SB Brininger, TL Schrader, JW Curtis, R Koceja, DM AF Goldman, Sarah B. Brininger, Teresa L. Schrader, John W. Curtis, Richard Koceja, David M. TI Analysis of Clinical Motor Testing for Adult Patients With Diagnosed Ulnar Neuropathy at the Elbow SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Article DE Rehabilitation; Ulnar nerve ID CUBITAL TUNNEL-SYNDROME; PERIPHERAL-NERVES; SIGN; COMPRESSION; PATHOPHYSIOLOGY; FASCICULATIONS AB Objective: To compare the dichotomous results for 7 ulnar nerve clinical motor tests (Froment's sign, Wartenberg's sign, finger flexion sign, Jeanne's sign, crossed finger test, Egawa's sign, presence of clinical fasciculations) with motor nerve conduction velocity findings. Design: A static group comparison design assessed for differences among dichotomous test outcomes with respect to motor nerve conduction velocity. Setting: Five medical facilities throughout the United States provided data for this study. Participants: Records from participants (N=26) with diagnosed ulnar neuropathy at the elbow were included for data analysis. Interventions: Not applicable. Main Outcome Measures: Demographic data included age, sex, handedness, duration of symptoms, and the number of days between the clinical and electrodiagnostic exam. Other dependent variables included motor conduction velocity of the ulnar nerve, compound muscle action potential amplitude, and the dichotomous clinical motor test outcomes. Results: Two motor signs, the presence of clinical fasciculations and a positive finger flexion sign, were identified more frequently (each present in 11 patients) than the other motor signs. An analysis of covariance revealed significant differences in motor nerve conduction velocity between positive and negative results for all the clinical motor tests except for the finger flexion sign. Significant chi-square analyses were found for the following comparisons: the presence of clinical fasciculations and Froment's sign, the finger flexion sign and the crossed finger test, Egawa's sign and Froment's sign, Warteberg's sign and Froment's sign, the crossed finger test and Froment's sign, and Egawa's sign and Wartenberg's sign. Conclusions: Some clinical motor tests are better than others at identifying early motor involvement, providing the rehabilitation professional some insight regarding the relative decrement of motor nerve conduction velocity when a selected test is positive. C1 [Goldman, Sarah B.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Brininger, Teresa L.] Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. [Schrader, John W.; Koceja, David M.] Indiana Univ, Dept Kinesiol, Sch Hlth Phys Educ & Recreat, Bloomington, IN 47405 USA. [Curtis, Richard] Hand Care Ctr, Orange Pk, FL USA. RP Goldman, SB (reprint author), USA, Environm Med Res Inst, Mil Performance Div, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM Sarah.goldman@us.army.mil NR 51 TC 2 Z9 2 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0003-9993 J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD NOV PY 2009 VL 90 IS 11 BP 1846 EP 1852 DI 10.1016/j.apmr.2009.06.007 PG 7 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 520XC UT WOS:000271881900005 PM 19887207 ER PT J AU Michener, LA Walsworth, MK Doukas, WC Murphy, KP AF Michener, Lori A. Walsworth, Matthew K. Doukas, William C. Murphy, Kevin P. TI Reliability and Diagnostic Accuracy of 5 Physical Examination Tests and Combination of Tests for Subacromial Impingement SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Article DE Diagnosis; Rehabilitation; Rotator cuff; Sensitivity and specificity; Shoulder; Shoulder impingement syndrome; Tendonitis ID SHOULDER PAIN; PATIENT CHARACTERISTICS; CLINICAL-TESTS; PRIMARY-CARE; MANAGEMENT; DISORDERS; LESIONS AB Objective: To investigate the reliability and diagnostic accuracy of individual tests and combination of tests for subacromial impingement syndrome (SAIS). Design: A prospective, blinded study design. Setting: Orthopedic surgeon shoulder clinic. Participants: Patients with shoulder pain (n=55, mean age=40.6y). Interventions: Patients were evaluated with 5 physical examination tests for SAIS: Neer, Hawkins-Kennedy, painful arc, empty can (Jobe), and external rotation resistance tests. Surgical diagnosis was the reference standard. Main Outcome Measures: Diagnostic accuracy calculated with a receiver operating characteristic (ROC) curve and sensitivity, specificity, positive likelihood ratio (+LR), and negative likelihood ratio (-LR). A forward stepwise binary logistic regression analysis was used to determine the best test combination for SAIS. An ROC curve analysis was also used to determine the cut point of the number of tests discriminating between the presence and absence of SAIS. Kappa coefficients and percent agreement assessed interrater reliability. Results: The ROC analyses revealed a significant area under the curve (AUC) (AUC=.67-.72, P<.05) for all tests, except for the Hawkins-Kennedy. The tests with a +LR greater than or equal to 2.0 were the painful arc (+LR=2.25; 95% CI, 1.33-3.81), empty can (+LR=3.90; 95% CI, 1.5-10.12), and the external rotation resistance tests (+LR=4.39; 95% CI, 1.74-11.07). Tests with -LR less than or equal to 0.50 were the painful arc (-LR=.38; 95% CI,.16-90), external rotation resistance (-LR=.50; 95% CI,.28-89), and Neer tests (-LR=.35; 95% CI,.12-.97). The regression analysis had no specific test combinations for confirming or ruling out SAIS. The ROC analysis was significant (AUC=39, P=.001), with a cut point of 3 positive tests out of 5 tests. Reliability was moderate to substantial agreement (kappa=.45-.67) for the painful arc, empty can, and external rotation resistance tests and fair strength of agreement (kappa=.39-.40) for the Neer and Hawkins-Kennedy tests. Conclusions: The single tests of painful arc, external rotation resistance, and Neer are useful screening tests to rule out SAIS. The single tests of painful arc, external rotation resistance, and empty can are helpful to confirm SAIS. The reliability of all tests was acceptable for clinical use. Based on reliability and diagnostic accuracy, the single tests of the painful arc, external rotation resistance, and empty can have the best overall clinical utility. The cut point of 3 or more positive of 5 tests can confirm the diagnosis of SAIS, while less than 3 positive of 5 rules out SAIS. C1 [Michener, Lori A.] Virginia Commonwealth Univ, Dept Phys Therapy, Med Coll Virginia, Richmond, VA 23298 USA. [Walsworth, Matthew K.] Virginia Commonwealth Univ Hlth Syst, Dept Radiol, Richmond, VA USA. [Doukas, William C.] Walter Reed Army Med Ctr, Dept Orthoped & Rehabil, Washington, DC 20307 USA. [Murphy, Kevin P.] Heekin Orthopaed Specialists, Jacksonville, FL USA. [Murphy, Kevin P.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Michener, LA (reprint author), Virginia Commonwealth Univ, Dept Phys Therapy, Med Coll Virginia, Med Coll Virginia Campus,POB 980224, Richmond, VA 23298 USA. EM lamichen@vcu.edu NR 26 TC 49 Z9 49 U1 0 U2 29 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0003-9993 J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD NOV PY 2009 VL 90 IS 11 BP 1898 EP 1903 DI 10.1016/j.apmr.2009.05.015 PG 6 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 520XC UT WOS:000271881900013 PM 19887215 ER PT J AU Fulco, CS Muza, SR Beidleman, B Jones, J Staab, J Rock, PB Cymerman, A AF Fulco, Charles S. Muza, Stephen R. Beidleman, Beth Jones, Juli Staab, Janet Rock, Paul B. Cymerman, Allen TI Exercise Performance of Sea-Level Residents at 4300 m After 6 Days at 2200 m SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE exercise; high altitude; staging; moderate altitude; acclimatization ID ACUTE MOUNTAIN-SICKNESS; CARBOHYDRATE SUPPLEMENTATION; MODERATE ALTITUDE; SYMPTOMS; QUESTIONNAIRE AB FULCO CS, MUZA SR, BEIDLEMAN B, JONES J, STAAB J, ROCK PB, CYMERMAN A. Exercise performance of sea-level residents at 4300 m after 6 days at 2200 m. Aviat Space Environ Med 2009; 80:955-61. Partial acclimatization resulting from,staging at moderate altitude reduce S acute mountain sickness during rapid exposure to higher altitudes (e.g, 4300 m) Whether slaving also benefits endurance performance has not yet been scientifically evaluated Purpose: Determine the effectiveness of staging at 2200 m on time trial (TT) performance of unacclimatized sea-level residents (SLR) during rapid exposure to 4300 m. There were 10 healthy m,en (mean +/- SE 21 +/- 1 yrs) who performed 720 kJ cycle TT at SL and following similar to 2 h of exposure to 4300 m (459 Torr) before (ALT-1) and after (ALT-2) living for 6 d at 2200 m (601 Torr) Methods: Hemoglobin concentration hematocrit (Hct), arterial oxygen saturation (S(a)O(2)), ratings of perceived exertion (RPE), and heart rate (HR) were measured before and during exercise Results: Compared to SL (73 6 min), TT performance was impaired (P < 0 01) by 38 1 6 min at ALT-1, but only by 18 7 +/- 3 min at ALT-2) The 44 +/- 8%, TT improvement at 4300 m was directly correlated with increases in exercise S(a)O(2) (R = 0 88, P < 0 03), but not to changes in [Hb] or Hct. In addition, RPE was lower (13 +/- 1 vs 16 +/- 1, P < 0.01) and HR remained at similar to 148 +/- 5 bpm despite performing the TT at a higher power Output during ALT-2 than ALT-1 (120 +/- 7 vs 100 +/- 10 W, P < 0 01) Conclusion: partial acclimatization resulting from staging attenuated the impairment in TT performance of SLR rapidly exposed to 4300 m. The close association between improved TT performance and changes in exercise S(a)O(2), compared to a lack of association with changes in [Hb] or Hct, suggest ventilatory acclimatization may have been the major factor contributing to the performance improvement C1 [Fulco, Charles S.; Muza, Stephen R.; Beidleman, Beth; Jones, Juli; Staab, Janet; Rock, Paul B.; Cymerman, Allen] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Fulco, CS (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. NR 22 TC 11 Z9 11 U1 1 U2 7 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD NOV PY 2009 VL 80 IS 11 BP 955 EP 961 DI 10.3357/ASEM.2540.2009 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 512RI UT WOS:000271267500006 PM 19911519 ER PT J AU Murray, CK Loo, FL Hospenthal, DR Cancio, LC Jones, JA Kim, SH Holcomb, JB Wade, CE Wolf, SE AF Murray, Clinton K. Loo, Florence L. Hospenthal, Duane R. Cancio, Leopoldo C. Jones, John A. Kim, Seung H. Holcomb, John B. Wade, Charles E. Wolf, Steven E. TI Re: Incidence of systemic fungal infection and related mortality following severe burns SO BURNS LA English DT Letter C1 [Murray, Clinton K.] Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Murray, Clinton K.; Hospenthal, Duane R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Loo, Florence L.] Pittsburgh Tissue Engn Initiat, Pittsburgh, PA USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Clinton.Murray@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 NR 4 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 J9 BURNS JI Burns PD NOV PY 2009 VL 35 IS 7 BP 1053 EP 1054 DI 10.1016/j.burns.2009.01.002 PG 2 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 513UI UT WOS:000271348900026 ER PT J AU Byrd, CM Bentley, WE AF Byrd, Christopher M. Bentley, William E. TI Quieting cross talk - the quorum sensing regulator LsrR as a possible target for fighting bacterial infections SO CELL RESEARCH LA English DT Editorial Material ID ESCHERICHIA-COLI; EXPRESSION; AI-2 C1 [Byrd, Christopher M.; Bentley, William E.] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA. [Byrd, Christopher M.] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Bentley, William E.] Univ Maryland, Ctr Biosyst Res, Inst Biotechnol, College Pk, MD 20742 USA. [Bentley, William E.] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. RP Bentley, WE (reprint author), Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA. EM bentley@eng.umd.edu NR 9 TC 6 Z9 7 U1 0 U2 6 PU INST BIOCHEMISTRY & CELL BIOLOGY PI SHANGHAI PA SIBS, CAS, 319 YUEYANG ROAD, SHANGHAI, 200031, PEOPLES R CHINA SN 1001-0602 EI 1748-7838 J9 CELL RES JI Cell Res. PD NOV PY 2009 VL 19 IS 11 BP 1229 EP 1230 DI 10.1038/cr.2009.122 PG 2 WC Cell Biology SC Cell Biology GA 524LU UT WOS:000272145600002 PM 19881524 ER PT J AU Ciminiello, P Dell'Aversano, C Dello Iacovo, E Fattorusso, E Forino, M Grauso, L Tartaglione, L Florio, C Lorenzon, P De Bortoli, M Tubaro, A Poli, M Bignami, G AF Ciminiello, Patrizia Dell'Aversano, Carmela Dello Iacovo, Emma Fattorusso, Ernesto Forino, Martino Grauso, Laura Tartaglione, Luciana Florio, Chiara Lorenzon, Paola De Bortoli, Marco Tubaro, Aurelia Poli, Mark Bignami, Gary TI Stereostructure and Biological Activity of 42-Hydroxy-palytoxin: A New Palytoxin Analogue from Hawaiian Palythoa Subspecies SO CHEMICAL RESEARCH IN TOXICOLOGY LA English DT Article ID DINOFLAGELLATE OSTREOPSIS-SIAMENSIS; MAMMALIAN SODIUM-PUMP; PUTATIVE PALYTOXIN; MASS-SPECTROMETRY; STEREOCHEMISTRY; CELLS; OUTBREAK; SEGMENT; MUSCLE; ENZYME AB This paper reports on the analysis of the toxin content from Palythoa tuberculosa and Palythoa toxica samples collected off of the Hawaiian coast. Our work, based on in-depth high-resolution liquid chromatography-mass spectrometry analysis along with extensive NMR study, led us to structurally characterize 42-hydroxy-palytoxin, a new palytoxin congener. This toxin and palytoxin itself appeared to be the major components of toxic extract from a P. tuberculosa sample, while 42-hydroxy-palytoxin was proven by far to be the main palytoxin derivative in A toxica. Functional studies on this new palytoxin-like compound suggest that the new palytoxin analogue and palytoxin itself present similar biological activities. C1 [Ciminiello, Patrizia; Dell'Aversano, Carmela; Dello Iacovo, Emma; Fattorusso, Ernesto; Forino, Martino; Grauso, Laura; Tartaglione, Luciana] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy. [Florio, Chiara; Lorenzon, Paola; De Bortoli, Marco] Univ Trieste, Dept Life Sci, I-34127 Trieste, Italy. [Tubaro, Aurelia] Univ Trieste, DMRN, I-34127 Trieste, Italy. [Poli, Mark] USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. [Bignami, Gary] PanThera Biopharma, Aiea, HI 96701 USA. RP Forino, M (reprint author), Univ Naples Federico II, Dipartimento Chim Sostanze Nat, Via D Montesano 49, I-80131 Naples, Italy. EM forino@unina.it RI Tartaglione, Luciana/F-4651-2010; Forino, Martino/F-4648-2010; Grauso, Laura/C-2374-2011; Dello Iacovo, Emma/C-2519-2011; Dell'Aversano, Carmela/H-1803-2013; OI Dell'Aversano, Carmela/0000-0001-8337-3029; Tartaglione, Luciana/0000-0003-0742-6955; Forino, Martino/0000-0001-8036-3546; Grauso, Laura/0000-0001-9165-8796 FU MURST (Rome, Italy) FX This work is a result of research supported by MURST PRIN (2007) (Rome, Italy). NMR experiments were performed at the "Centro di Servizi Interdipartimentale di Analisi Strumentale", University of Naples "Federico II", Italy. The assistance of the staff is gratefully appreciated. NR 42 TC 52 Z9 52 U1 3 U2 12 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0893-228X EI 1520-5010 J9 CHEM RES TOXICOL JI Chem. Res. Toxicol. PD NOV PY 2009 VL 22 IS 11 BP 1851 EP 1859 DI 10.1021/tx900259v PG 9 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology SC Pharmacology & Pharmacy; Chemistry; Toxicology GA 517YD UT WOS:000271654100014 PM 19852440 ER PT J AU Taylor, S Lever, JH Fadden, J Perron, N Packer, B AF Taylor, Susan Lever, James H. Fadden, Jennifer Perron, Nancy Packer, Bonnie TI Outdoor weathering and dissolution of TNT and Tritonal SO CHEMOSPHERE LA English DT Article DE TNT; Tritonal; Dissolution model; Outdoor tests; Photo-transformation; Fate ID HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE RDX; 2,4,6-TRINITROTOLUENE; RANGE; HMX AB Low-order detonations of military munitions scatter cm-sized chunks of high-explosives onto military range soils, where rainfall can dissolve and then transport the explosives to groundwater. We present 1 year of mass-loss data obtained from cm-sized chunks of the frequently used explosives TNT (2,4,6-trinitrotoluene) and Tritonal (an 80:20 mixture of TNT and aluminum flakes) exposed outdoors to weather and dissolve under natural conditions. The explosive chunks rested on glass frits in individual funnels and all precipitation interacting with them was collected and analyzed. Mass balance data reveal that TNT in the water samples accounts for only about one-third of the TNT lost from the chunks. The creation of photo-transformation products on the solid chunks, and their subsequent dissolution or sublimation, probably accounts for the other two-thirds. Although these products cannot, as yet, be quantified they are intrinsic to the outdoor weathering and fate of TNT-based explosives. TNT in our water samples was not photo-transformed. Thus, we used the yearlong, dissolved-mass time-series to validate a drop-impingement dissolution model for TNT. The model used measured rainfall and air temperature data as input, and the results agreed remarkably well with TNT dissolved-mass time-series measured for the year. This model can estimate annual TNT influx into range soils using annual rainfall and particle-size distributions. Nevertheless, large uncertainties remain in the numbers and sizes of TNT particles scattered on military ranges and the identities and fates of the photo-transformation products. Published by Elsevier Ltd. C1 [Taylor, Susan] USA, Cold Reg Res & Engn Lab, Erdc, Hanover, NH 03755 USA. [Packer, Bonnie] USA, Environm Command, Aberdeen Proving Ground, MD 21010 USA. RP Taylor, S (reprint author), USA, Cold Reg Res & Engn Lab, Erdc, 72 Lyme Rd, Hanover, NH 03755 USA. EM Susan.Taylor@usace.army.mil FU Strategic Environmental Research and Development Program,; SERDP [ER-1482] FX The authors thank Dennis Lambert for his help with lab analyses, Pamela Collins for help with the field set-up and Kerry Claffey for managing the meteorological data. We thank two unknown reviewers for insightful comments that strengthened the paper. The Strategic Environmental Research and Development Program, SERDP ER-1482 sponsored this work, and Dr. Andrea Leeson, our program manager, is thanked for her support. NR 24 TC 23 Z9 23 U1 2 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD NOV PY 2009 VL 77 IS 10 BP 1338 EP 1345 DI 10.1016/j.chemosphere.2009.09.040 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA 529LY UT WOS:000272519900011 PM 19846196 ER PT J AU Bennett, ER Clausen, J Linkov, E Linkov, I AF Bennett, Erin R. Clausen, Jay Linkov, Eugene Linkov, Igor TI Predicting physical properties of emerging compounds with limited physical and chemical data: QSAR model uncertainty and applicability to military munitions SO CHEMOSPHERE LA English DT Article DE QSAR; EPI Suite (TM); Explosives; RDX; TNT ID OCTANOL/WATER PARTITION-COEFFICIENTS; RISK-ASSESSMENT; LOG-P; SOLUBILITY AB Reliable, up-front information on physical and biological properties of emerging materials is essential before making a decision and investment to formulate, synthesize, scale-up, test, and manufacture a new material for use in both military and civilian applications. Multiple quantitative structure-activity relationships (QSARs) software tools are available for predicting a material's physical/chemical properties and environmental effects. Even though information on emerging materials is often limited, QSAR software output is treated without sufficient uncertainty analysis. We hypothesize that uncertainty and variability in material properties and uncertainty in model prediction can be too large to provide meaningful results. To test this hypothesis, we predicted octanol water partitioning coefficients (log P) for multiple, similar compounds with limited physical-chemical properties using six different commercial log P calculators (KOWWIN, MarvinSketch, ACD/Labs, ALogP, CLogP, SPARC). Analysis was done for materials with largely uncertain properties that were similar, based on molecular formula, to military compounds (RDX, BTTN, TNT) and pharmaceuticals (Carbamazepine, Gemfibrizol). We have also compared QSAR modeling results for a well-studied pesticide and pesticide breakdown product (Atrazine, DDE). Our analysis shows variability due to structural variations of the emerging chemicals may be several orders of magnitude. The model uncertainty across six software packages was very high (10 orders of magnitude) for emerging materials while it was low for traditional chemicals (e.g. Atrazine). Thus the use of QSAR models for emerging materials screening requires extensive model validation and coupling QSAR output with available empirical data and other relevant information. Published by Elsevier Ltd. C1 [Clausen, Jay] USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. [Bennett, Erin R.; Linkov, Igor] Intertox Inc, Seattle, WA USA. [Linkov, Eugene] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA. RP Clausen, J (reprint author), USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA. EM Jay.L.Clausen@usace.army.mil FU Strategic Environmental Research and Development Program (SERDP) FX The authors would like to acknowledge funding for this project from the Strategic Environmental Research and Development Program (SERDP). The authors are indebted to reviews and discussions with N. Korte, C.M. Reynolds and D. Ringleberg. NR 27 TC 9 Z9 9 U1 3 U2 22 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD NOV PY 2009 VL 77 IS 10 BP 1412 EP 1418 DI 10.1016/j.chemosphere.2009.09.003 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA 529LY UT WOS:000272519900022 PM 19793608 ER PT J AU Lettieri, CJ Collen, JF Eliasson, AH Quast, TM AF Lettieri, Christopher J. Collen, Jacob F. Eliasson, Arn H. Quast, Timothy M. TI Sedative Use During Continuous Positive Airway Pressure Titration Improves Subsequent Compliance A Randomized, Double-Blind, Placebo-Controlled Trial SO CHEST LA English DT Article ID OBSTRUCTIVE SLEEP-APNEA; CPAP USE; POLYSOMNOGRAPHY; HYPERTENSION; ESZOPICLONE; PREDICTORS; THERAPY AB Background: The initial experience with continuous positive airway pressure (CPAP) may predict subsequent compliance. In a retrospective study, we found that premedication with nonbenzodiazepine sedative-hypnotic agents during CIAP titration polysomnography independently predicted short-term compliance. To validate these findings, we conducted a prospective clinical trial to assess whether premedication with eszopiclone prior to CPAP titration would improve short-term CPAP compliance. Methods: Subjects in this randomized, double-blind, placebo-controlled trial received 3 mg of eszopiclone or matching placebo prior to undergoing CPAP titration polysomnography. We compared the quality of CPAP titrations and objective measures of compliance during the first 4 to 6 weeks of therapy between the two groups. Results: We enrolled 117 subjects, and 98 subjects completed the protocol (eszopiclone, 50 subjects; placebo, 48 subjects). Other than there being more women in the eszopiclone group, the groups were similar at baseline. Compared with placebo, premedication with eszopiclone significantly improved mean (+/- SD) sleep efficiency (87.8 +/- 5.8% vs 80.1 +/- 10.5%, respectively; p = 0.002) and mean total sleep time (350.9 +/- 33.6 min vs 319.7 +/- 48.7 min, respectively; p = 0.007). A trend toward improved sleep latency (19.4 +/- 16.1 min vs 31.8 +/- 30.4 min, respectively; p = 0.08) and the number of residual obstructive events observed at the final CPAP pressure (6.4 +/- 7 events/h vs 12.8 +/- 14.6 events/h, respectively; p = 0.08) during polysomnography was found. Eszopiclone significantly improved CPAP compliance. Among subjects premedicated with eszopiclone, CPAP was used on a higher percentage of nights (75.9 +/- 20.0% vs 60.1 +/- 24.3%, respectively; p = 0.005) and for more hours per night (4.8 +/- 1.5 h vs 3.9 +/- 1.8 h, respectively; p = 0.03). Conclusions: Premedication with eszopiclone on the night of CPAP titration improved the quality of CPAP titration and led to significantly greater short-term compliance. (CHEST 2009; 136:1263-1268) C1 [Lettieri, Christopher J.; Collen, Jacob F.; Eliasson, Arn H.; Quast, Timothy M.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Lettieri, Christopher J.; Eliasson, Arn H.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. RP Lettieri, CJ (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM christopher.lettieri@us.army.mil FU Sepracor Inc (Marlborough, MA) FX Study medications were provided by Sepracor Inc (Marlborough, MA). No other financial support was provided. NR 27 TC 25 Z9 28 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD NOV PY 2009 VL 136 IS 5 BP 1263 EP 1268 DI 10.1378/chest.09-0811 PG 6 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 521JD UT WOS:000271916000012 PM 19567493 ER PT J AU Kenney, KM Marzo, MC Ondrasik, NR Wisenbaugh, T AF Kenney, Kimberly M. Marzo, Mitchell C. Ondrasik, Nicholas R. Wisenbaugh, Thomas TI Percutaneous Coronary Intervention Outcomes in a Low-Volume Center Survival, Stent Thrombosis, and Repeat Revascularization SO CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES LA English DT Article DE angioplasty; stents; mortality; statistics ID DRUG-ELUTING STENTS; MORTALITY; CARDIOLOGY; REGISTRY AB Background-American College of Cardiology (ACC) guidelines state that percutaneous coronary interventions (PCI) be performed at centers and by operators with high-volume (>400 yearly/center) whose historical and current risk-adjusted outcomes statistics are comparable to those reported in large registries. Tripler Army Medical Center is a low-volume treatment facility but has a geographic need and special mission requirement for providing this service. Methods and Results-We computed 30-day incidence of stent thrombosis, need for repeat revascularization, and all-cause mortality for all PCIs performed at Tripler from January 2002 through June 2008. The New York State Registry regression model was selected among 3 risk-adjustment models that we assessed in our patients. This model was used to compute expected mortality rate based on patient risk factors. The 30-day incidence of stent thrombosis and repeat revascularization was also determined, and the long-term incidence of these events was estimated with the Kaplan-Meier method as was survival. For all 546 PCI procedures, 30-day mortality was 1.47%, the incidence of stent thrombosis 2.1%, the incidence of any repeat revascularization 5.1%, and the combined event rate 5.9%. Based on risk factors used in the New York State Registry, our expected mortality was 1.93% and not significantly different from the observed rate. Although survival at 1 and 3 years appeared comparable with benchmarks at 94.6% and 89.3%, as did repeat revascularization rates at 13.0% and 21.4%, the incidence of stent thrombosis was regarded as high whether the definition included possible cases (3.2% and 3.9%) or only those regarded as definite or probable (2.7% and 3.1%). We did not identify any remediable risk factors for stent thrombosis, nor were we able to identify significant differences by year or by operator. However, visual inspection of a plot of deciles of New York State risk of death demonstrated 2 outlier cases among the 8 who died, who could have been considered candidates for thorough peer review. Conclusion-We recommend other low-volume interventional programs enter all patients undergoing PCI into a database, their own local registry even if not a national one such as the American College of Cardiology National Cardiovascular Data Registry, obtain information about survival and cardiac events during follow-up, compute and risk-adjust in-hospital or 30-day mortality, and use the objective assessment of risk in individual patients to identify outliers when outcome is adverse, and possibly as a means of triaging patients to appropriate therapy before choosing PCI. (Circ Cardiovasc Qual Outcomes. 2009;2:671-677.) C1 [Kenney, Kimberly M.; Marzo, Mitchell C.; Ondrasik, Nicholas R.; Wisenbaugh, Thomas] Tripler Army Med Ctr, Tripler, HI USA. RP Wisenbaugh, T (reprint author), MCHK DMC, 1 Jarrett White Rd, Tripler, HI 96859 USA. EM thomas.wisenbaugh@us.army.mil NR 17 TC 5 Z9 5 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1941-7713 J9 CIRC-CARDIOVASC QUAL JI Circ.-Cardiovasc. Qual. Outcomes PD NOV PY 2009 VL 2 IS 6 BP 671 EP U234 DI 10.1161/CIRCOUTCOMES.109.867077 PG 9 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 575PD UT WOS:000276078500022 PM 20031907 ER PT J AU Johnson, GH Mitchell, LA Brown, JM AF Johnson, Gabriel H. Mitchell, Lex A. Brown, Jerry M. TI F-18 FDG PET/CT Imaging of Cortical Bone Metastases SO CLINICAL NUCLEAR MEDICINE LA English DT Editorial Material DE F-18 FDG PET/CT; cortical bone metastases; 3 phase bone scan AB Osteolytic cortical bone metastases (CBM) saucerize cortical bone surfaces and, especially in tubular bones, may demonstrate a unique appearance differentiating them from the much more commonly observed metastatic disease in the medullary space of bone. A Tc-99m methylene diphosphonate 3 phase bone scan in our 58-year-old male patient who presented with a 3-month history of worsening bilateral lower extremity pain was positive in all 3 phases at the mid-diaphyseal levels of both tibiae. Correlative plain film radiographs demonstrated extensive geographic cortical osteolysis in both tibiae consistent with CBM. Extramedullary hypermetabolic masses associated with cortical osteolysis were demonstrated at these tibial sites by F-18 FDG PET/CT scanning. A presumed primary lung poorly differentiated neoplasm with extensive dissemination in and beyond the chest to other osseous structures, cervical lymph nodes, both adrenal glands, and brain was the most likely source of his CBM. C1 [Johnson, Gabriel H.; Mitchell, Lex A.; Brown, Jerry M.] Tripler Army Med Ctr, Dept Radiol, Honolulu, HI 96859 USA. RP Brown, JM (reprint author), Tripler Army Med Ctr, Dept Radiol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM jerry.brown@amedd.amy.mil NR 10 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD NOV PY 2009 VL 34 IS 11 BP 802 EP 805 PG 4 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 515UU UT WOS:000271499200016 PM 19851181 ER PT J AU Harrison, SA AF Harrison, Stephen A. TI Non-Alcoholic Steatohepatitis Preface SO CLINICS IN LIVER DISEASE LA English DT Editorial Material C1 Univ Texas Hlth Ctr San Antonio, Brooke Army Med Ctr, Div Gastroenterol & Hepatol, Dept Med, Ft Sam Houston, TX 78234 USA. RP Harrison, SA (reprint author), Univ Texas Hlth Ctr San Antonio, Brooke Army Med Ctr, Div Gastroenterol & Hepatol, Dept Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM stephen.harrison@amedd.army.mil NR 1 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 1089-3261 J9 CLIN LIVER DIS JI Clin. Liver Dis. PD NOV PY 2009 VL 13 IS 4 BP XIII EP XIV DI 10.1016/j.cld.2009.08.001 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 514JJ UT WOS:000271390100001 PM 19818301 ER PT J AU Page, JM Harrison, SA AF Page, John M. Harrison, Stephen A. TI NASH and HCC SO CLINICS IN LIVER DISEASE LA English DT Article DE Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Hepatocellular carcinoma; Cryptogenic cirrhosis; Hepatic steatosis ID NONALCOHOLIC FATTY LIVER; HEPATOCELLULAR-CARCINOMA; NATURAL-HISTORY; UNITED-STATES; RISK-FACTORS; INSULIN-RESISTANCE; DIABETES-MELLITUS; CRYPTOGENIC CIRRHOSIS; HEPATITIS-C; FOLLOW-UP AB Primary liver cancer is the fifth most common malignancy worldwide and the third leading cause of cancer mortality. Non-alcoholic fatty liver disease is the most common cause of chronic liver disease in the United States encompassing a spectrum of entities marked by hepatic steatosis in the absence of significant alcohol consumption. Although simple steatosis follows a generally benign course, the more aggressive form, non-alcoholic steatohepatitis, can progress to cirrhosis and result in complications including hepatocellular carcinoma. A significant number of cases of hepatocellular carcinoma remain cryptogenic without known underlying chronic liver disease. It is increasingly recognized that non-alcoholic steatohepatitis likely accounts for a substantial portion of cryptogenic hepatocellular carcinoma. C1 [Page, John M.; Harrison, Stephen A.] Brooke Army Med Ctr, Gastroenterol Serv, Dept Med, Ft Sam Houston, TX 78234 USA. RP Harrison, SA (reprint author), Brooke Army Med Ctr, Gastroenterol Serv, Dept Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM stephen.harrison@amedd.army.mil NR 98 TC 67 Z9 68 U1 0 U2 5 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 1089-3261 J9 CLIN LIVER DIS JI Clin. Liver Dis. PD NOV PY 2009 VL 13 IS 4 BP 631 EP + DI 10.1016/j.cld.2009.07.007 PG 18 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 514JJ UT WOS:000271390100010 PM 19818310 ER PT J AU Pielmeier, C Marshall, HP AF Pielmeier, Christine Marshall, Hans-Peter TI Rutschblock-scale snowpack stability derived from multiple quality-controlled SnowMicroPen measurements SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article; Proceedings Paper CT International Snow Science Workshop CY SEP 21-27, 2008 CL Whistler, CANADA DE Snow cover; Snow cover stability; Snow stability evaluation; Micro penetrometer; Mechanical properties; Avalanche forecasting ID PENETROMETER; AVALANCHES AB Stability prediction from SnowMicroPen (SMP) profiles would support avalanche forecasting operations, since objective stability information could be gathered more quickly than with standard tests, thereby allowing sampling at higher resolution and over larger spatial scales. Previous studies have related the snow properties derived from the SMP to observed snow properties at Rutschblock (RB) and compression test failure planes. The goals of this study are to show to what extent snowpack stability for artificial triggering, based on RB. can be derived from SMP measurements and how multiple measurements at the RB scale improve the results. Measurements at 36 different sites were used for the development of a classification scheme. Each site included a RB test, a manual profile, and 6 to 10 adjacent SMP measurements, for a total of 262 SMP profiles. A recently improved SMP theory was applied to estimate the micro-structural and mechanical properties of manually defined weak layers and slab layers. SMP signal quality control and different noise treatment methods were taken into consideration in the analysis. The best and most robust predictor of RB stability was the weak layer micro-scale strength. In combination with the SMP-estimated mean density of the slab layer, the total accuracy of predicting RB stability classes was 85% over the entire dataset, and 88% when signals with obvious signal dampening (11% of the dataset) were removed. The total accuracy increased when multiple SMP measurements at the RB scale were used to calculate the mean weak layer strength, when compared to using just one SMP measurement at a site. The analysis was robust to trends and offsets in the absolute SMP force, which was a frequent signal error. However, it was sensitive to dampened or disturbed SMP force micro variance. The sensitivity analysis also showed that the best predictor of instability. the weak layer micro-scale strength, was robust to the choice of SMP signal noise removal method. (C) 2009 Elsevier B.V. All rights reserved. C1 [Pielmeier, Christine] WSL Inst Snow & Avalanche Res SLF, CH-7260 Davos, Switzerland. [Marshall, Hans-Peter] Boise State Univ, Ctr Geophys Invest Shallow Subsurface, Boise, ID 83725 USA. [Marshall, Hans-Peter] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Pielmeier, C (reprint author), WSL Inst Snow & Avalanche Res SLF, Fluelastr 11, CH-7260 Davos, Switzerland. EM pielmeier@slf.ch RI Marshall, Hans-Peter/A-2374-2010 OI Marshall, Hans-Peter/0000-0002-4852-5637 NR 25 TC 14 Z9 14 U1 3 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X EI 1872-7441 J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD NOV PY 2009 VL 59 IS 2-3 SI SI BP 178 EP 184 DI 10.1016/j.coldregions.2009.06.005 PG 7 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA 523GD UT WOS:000272059600010 ER PT J AU Lutz, E Birkeland, K Marshall, HP AF Lutz, Eric Birkeland, Karl Marshall, Hans-Peter TI Quantifying changes in weak layer microstructure associated with artificial load changes SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article; Proceedings Paper CT International Snow Science Workshop CY SEP 21-27, 2008 CL Whistler, CANADA DE Snow microstructure; Stability; Loading event; Elastic rebound; SnowMicroPen ID SNOW AB Researchers and practitioners have long utilized a variety of penetrometers to investigate the snowpack. Identifying definitive relationships between penetrometer-derived microstructural information and stability has been challenging. The purpose of this study is two-fold: 1. We propose a simple field test to establish relationships between load and penetrometer-derived microstructural estimates. 2. We utilize the SnowMicroPen (SMP) to quantify changes in weak layer residual strength and microstructural dimension associated with an artificial loading event Our dataset is from Moonlight Basin, Montana and includes three modified loaded-column tests, each paired with 5 SMP profiles. Depth hoar comprised the targeted weak layer. Results indicate that loading caused the residual strength and rupture frequency to decrease significantly. Much like a compression test at a micro-scale, the force required for the SMP to rupture individual structures as well as the micro-scale strength decreased significantly when the slab stress was increased by artificially adding blocks of snow. A decrease in observed rupture frequency within the weak layer (or an increase in the distance between ruptured structures) also occurred after the loading event. probably because some structures within the weak layer had already failed or were so close to failing that the penetrometer could not detect their rupture. Due in part to the large difference in loads, microstructural differences between the natural and loaded columns were significant enough that only one profile would have been necessary to determine a significant difference in residual strength. Artificial removal of slab stress resulted in greater rupture forces and larger microstructures, likely due to elastic rebound. (C) 2009 Elsevier B.V. All rights reserved. C1 [Lutz, Eric] Univ Washington, Seattle, WA 98195 USA. [Lutz, Eric; Birkeland, Karl] Montana State Univ, Dept Earth Sci, Bozeman, MT 59717 USA. [Birkeland, Karl] US Forest Serv, USDA, Natl Avalanche Ctr, Bozeman, MT USA. [Marshall, Hans-Peter] Boise State Univ, Ctr Geophys Invest Shallow Subsurface, Boise, ID 83725 USA. [Marshall, Hans-Peter] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Lutz, E (reprint author), Univ Washington, Seattle, WA 98195 USA. EM snowscience@gmail.com RI Marshall, Hans-Peter/A-2374-2010 OI Marshall, Hans-Peter/0000-0002-4852-5637 NR 27 TC 8 Z9 8 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD NOV PY 2009 VL 59 IS 2-3 BP 202 EP 209 DI 10.1016/j.coldregions.2009.04.003 PG 8 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA 523GD UT WOS:000272059600013 ER PT J AU Gallaway, MS Waller, DK Canfield, MA Scheuerle, A AF Gallaway, M. Shayne Waller, D. Kim Canfield, Mark A. Scheuerle, Angela CA Natl Birth Defects Prevention Stud TI The association between use of spermicides or male condoms and major structural birth defects SO CONTRACEPTION LA English DT Article DE Spermicides; Male condoms; Birth defects; Contraception; Congenital anomaly; Case-control study ID CONGENITAL-MALFORMATIONS; VAGINAL SPERMICIDES; PREVENTION; PREGNANCY AB Background: Women may become pregnant while using contraceptives. Commonly used contraceptives containing spermicides may or may not be associated with an increased occurrence of structural birth defects. Study Design: Utilizing data from the National Birth Defects Prevention Study, we assessed maternal reports of spermicide and male condom use 1 to 3 months following conception among case (n=11,050) and control (n=4723) mothers. We assessed the association between spermicide use and 27 types of birth defects and that between condom use and 32 types of birth defects. Results: Maternal spermicide use during the first 3 months following conception was associated with a significant increase in the occurrence of only 1 of 27 birth defects, perimembranous ventricular septal defects (adjusted odds ratio=2.40, 95% confidence interval=1.25-4.62). There was no significant association between maternal use of male condoms during the first 3 months following conception and any of 32 types of birth defects. Conclusions: The increased occurrence of perimembranous ventricular septal defects among spermicide users may be real or may be a chance finding. Overall, the findings are consistent with those of most previous studies that observed no increased risk for birth defects among spermicide users. (C) 2009 Elsevier Inc. All rights reserved. C1 [Gallaway, M. Shayne; Waller, D. Kim] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Houston, TX 77030 USA. [Scheuerle, Angela] Tesserae Genet, Dallas, TX 75230 USA. [Canfield, Mark A.; Scheuerle, Angela] Texas Dept State Hlth Serv, Birth Defects Epidemiol & Surveillance Branch, Austin, TX 78756 USA. RP Gallaway, MS (reprint author), USA, Ctr Hlth Promot & Prevent Med, Behav & Social Hlth Outcomes Program, Directorate Epidemiol & Dis Surveillance, Aberdeen Proving Ground, MD 21010 USA. EM shayne.gallaway@us.army.mil RI Publications, NBDPS/B-7692-2013 FU Centers for Disease Control and Prevention; [U50/CCU613232]; [PA 02081] FX This study was supported in part by the Centers for Disease Control and Prevention-funded Texas Center for Birth Defects Research and Prevention by a cooperative agreement with the Centers for Disease Control and Prevention Centers of Birth Defects Research and Prevention (Grant Number U50/CCU613232, PA 02081). The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. NR 16 TC 1 Z9 1 U1 1 U2 8 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0010-7824 J9 CONTRACEPTION JI Contraception PD NOV PY 2009 VL 80 IS 5 BP 422 EP 429 DI 10.1016/j.contraception.2009.03.007 PG 8 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 515UL UT WOS:000271498300004 PM 19835715 ER PT J AU Goodrich, T Rubio, F Cutler, JL AF Goodrich, Timothy Rubio, Frank Cutler, Jeffrey L. TI Otitis media and antihistamines SO CURRENT ALLERGY AND ASTHMA REPORTS LA English DT Review ID RESPIRATORY-TRACT INFECTIONS; ALLERGIC RHINITIS; EUSTACHIAN-TUBE; EFFUSION; CHILDREN; RAT AB Otitis media with effusion (OME) and acute otitis media (AOM) continue to be a significant source of morbidity in the United States, as they account for more than 3.5 billion dollars in annual costs, and OME is the sixth most common reason for an emergency department visit. The efficacy of antihistamines in the treatment of OME/AOM has been thoroughly refuted in the literature during the past three decades. However, most studies to date have used first-generation antihistamines with or without decongestants. We propose that second-generation antihistamines may have increased efficacy in the treatment of OME/AOM because of their greater selectivity for histamine receptors and lack of anti-cholinergic activity. Further clinical trials may be warranted, as medical treatment with second-generation antihistamines, if proven more efficacious, may reduce the need for antibiotic treatment and surgical intervention. C1 [Cutler, Jeffrey L.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Cutler, JL (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM jeffrey.cutler@hotmail.com NR 27 TC 2 Z9 2 U1 0 U2 0 PU CURRENT MEDICINE GROUP PI PHILADELPHIA PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA SN 1529-7322 J9 CURR ALLERGY ASTHM R JI Curr. Allergy Asthma Rep. PD NOV PY 2009 VL 9 IS 6 BP 456 EP 459 DI 10.1007/s11882-009-0067-5 PG 4 WC Allergy; Immunology SC Allergy; Immunology GA 505YB UT WOS:000270736900011 PM 19814918 ER PT J AU Scrimgeour, AG Condlin, ML AF Scrimgeour, Angus G. Condlin, Michelle L. TI Zinc and micronutrient combinations to combat gastrointestinal inflammation SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE LA English DT Article DE celiac disease; HIV/AIDS-related diarrhea; inflammatory bowel disease; micronutrient supplementation ID GLUTEN-FREE DIET; CELIAC-DISEASE; BOWEL-DISEASE; CROHNS-DISEASE; SERUM ZINC; ULCERATIVE-COLITIS; CONTROLLED-TRIAL; OLMSTED COUNTY; SOUTH-AFRICA; HIV STATUS AB Purpose of review To examine current evidence for dietary supplementation with zinc and other micronutrients for primary prevention of multiple micronutrient deficiencies that are known to result from therapies used in the treatment of gastrointestinal inflammatory disorders. Recent findings Epidemiological observations and clinical findings have strengthened the concept that both nutritional deficiencies and nutritional excesses impair the gastrointestinal response(s) and alter susceptibility to inflammation and other diseases. The interaction of micronutrient intake, biochemical indicators of nutritional status, and four specific gastrointestinal inflammation states are reviewed. These conditions include celiac disease and concomitant micronutrient deficiencies resulting from the sustained adherence to a gluten-free diet; micronutrient nutrition as an important determinant of immunity for two major types of inflammatory bowel disease: ulcerative colitis and Crohn's disease; and HIV/AIDS-related diarrhea and concomitant micronutrient deficiencies which may be exacerbated by the initiation of highly active antiretroviral therapy. Summary For each inflammation 'state', enhancement of micronutrient status can improve immunocompetance and minimize therapeutic side-effects. The impact of single-micronutrient deficiencies on immune responses, and the possible impact of uncorrected micronutrient status are discussed. C1 [Scrimgeour, Angus G.; Condlin, Michelle L.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. RP Scrimgeour, AG (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. EM angus.scrimgeour@us.army.mil FU US Army Medical Research and Materiel Command FX The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Army or the Department of Defense. NR 57 TC 19 Z9 19 U1 0 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1363-1950 J9 CURR OPIN CLIN NUTR JI Curr. Opin. Clin. Nutr. Metab. Care PD NOV PY 2009 VL 12 IS 6 BP 653 EP 660 DI 10.1097/MCO.0b013e3283308dd6 PG 8 WC Endocrinology & Metabolism; Nutrition & Dietetics SC Endocrinology & Metabolism; Nutrition & Dietetics GA 513BI UT WOS:000271296600016 PM 19684516 ER PT J AU Hurst, FP Abbott, KC AF Hurst, Frank P. Abbott, Kevin C. TI Acute phosphate nephropathy SO CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION LA English DT Review DE acute kidney injury; colonoscopy; nephrocalcinosis; phosphate nephropathy ID ORAL SODIUM-PHOSPHATE; POLYETHYLENE-GLYCOL; RENAL-FUNCTION; BOWEL PREPARATIONS; KIDNEY INJURY; COLONOSCOPY; FAILURE; NEPHROCALCINOSIS; ABSORPTION; SAFETY AB Purpose of review Acute phosphate nephropathy (APN) has been identified in renal biopsy specimens of patients exposed to oral sodium phosphate (OSP) bowel purgatives. Biopsy confirmed cases presented with bland urinary sediment, low-grade proteinuria, and varying degrees of creatinine elevation. Prospective identification of APN is difficult in that definitive diagnosis requires renal biopsy, and biopsy is rarely performed for patients with this clinical presentation. Recent findings Observational studies evaluating acute kidney injury after OSP exposure using interval changes in creatinine as a surrogate for APN have reported conflicting results. Although these studies have produced estimates of disease occurrence, they have been unable to definitively quantify the overall risk of APN with OSP as compared with alternative bowel-cleansing agents. Summary On the basis of association of APN and OSP, the US Food and Drug Administration issued a boxed warning and manufacturers have ceased production and distribution of some OSP products. As this is a temporary solution, more studies are needed to delineate the pathophysiology of this disease and to better identify the subset of the population at risk for APN. C1 [Hurst, Frank P.; Abbott, Kevin C.] Walter Reed Army Med Ctr, Dept Nephrol, Serv Nephrol, Washington, DC 20307 USA. [Hurst, Frank P.; Abbott, Kevin C.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. RP Hurst, FP (reprint author), Walter Reed Army Med Ctr, Dept Nephrol, Serv Nephrol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM frank.hurst@us.army.mil OI Abbott, Kevin/0000-0003-2111-7112 NR 24 TC 5 Z9 6 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1062-4821 J9 CURR OPIN NEPHROL HY JI Curr. Opin. Nephrol. Hypertens. PD NOV PY 2009 VL 18 IS 6 BP 513 EP 518 DI 10.1097/MNH.0b013e32833096af PG 6 WC Urology & Nephrology; Peripheral Vascular Disease SC Urology & Nephrology; Cardiovascular System & Cardiology GA 515UO UT WOS:000271498600009 PM 19636249 ER PT J AU Lazarus, A Fuhrer, G Myers, JN Holmes, J Parrish, S Turner, JF King, CS Kelly, W AF Lazarus, Angeline Fuhrer, Gregory Myers, Janet N. Holmes, Jennifer Parrish, Scott Turner, J. F. King, Christopher S. Kelly, William TI Sarcoidosis Introduction SO DM DISEASE-A-MONTH LA English DT Editorial Material ID PULMONARY SARCOIDOSIS; CARDIAC SARCOIDOSIS; RANDOMIZED-TRIAL; DOUBLE-BLIND; CUTANEOUS SARCOIDOSIS; METHOTREXATE; HYDROXYCHLOROQUINE; INFLIXIMAB; THERAPY; CHLOROQUINE C1 [Lazarus, Angeline; Fuhrer, Gregory] Natl Naval Med Ctr, Dept Internal Med, Bethesda, MD USA. [Myers, Janet N.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Holmes, Jennifer; Parrish, Scott; Turner, J. F.] Natl Naval Med Ctr, Dept Pulm Med, Bethesda, MD USA. [Kelly, William] Uniformed Serv Univ Hlth Sci, Dept Pulm Med, Walter Reed Army Med Ctr, Washington, DC USA. RP Lazarus, A (reprint author), Natl Naval Med Ctr, Dept Internal Med, Bethesda, MD USA. NR 46 TC 3 Z9 3 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0011-5029 J9 DM-DIS MON JI DM-Dis.-a-Mon. PD NOV PY 2009 VL 55 IS 11 BP 648 EP 718 DI 10.1016/j.disamonth.2009.04.007 PG 71 WC Medicine, General & Internal SC General & Internal Medicine GA 515DQ UT WOS:000271447400001 PM 19857639 ER PT J AU Kim, T Foutch, DA Wilcoski, J LaFave, JM AF Kim, Taewan Foutch, Douglas A. Wilcoski, James LaFave, James M. TI Response Modification Factors for RC Case-Study Buildings with Structural Walls SO EARTHQUAKE SPECTRA LA English DT Article DE bending; building standards; design engineering; earthquake engineering; floors; plates (structures); reinforced concrete; seismology; shear strength; steel; structural engineering; walls ID REINFORCED-CONCRETE; MODEL AB A rational approach for determining the response modification factor, R, has been applied to reinforced concrete (RC) shear wall buildings designed under current codes and standards of practice. The approach is founded upon the performance-based evaluation framework from the SAC project; however, new values for various parameters were derived specifically for RC shear wall buildings because the SAC parameters were for steel moment frame buildings. Typical RC shear wall buildings were designed consisting of solid, flexure-dominated structural walls for lateral load resistance and a flat plate floor system for gravity loads. The performance of each building was then evaluated by calculating the confidence level of achieving the design objective. The buildings designed per the current R-value of 6 demonstrated good performances, meaning that the confidence levels of avoiding collapse were greater than the target value of 90%. The confidence levels for shear wall buildings with greater R-values were also determined, suggesting that further study could provide the basis for justifying an R-value of 7 for the special RC shear wall structural system. C1 [Kim, Taewan] Kangwon Natl Univ, Chunchon Si 200701, Kangwon Do, South Korea. [Foutch, Douglas A.; LaFave, James M.] Univ Illinois, Urbana, IL 61801 USA. [Wilcoski, James] USA, ERDC CERL, CEERD CF M, Champaign, IL 61826 USA. RP Kim, T (reprint author), Kangwon Natl Univ, 1 Kangwondaehak Gil, Chunchon Si 200701, Kangwon Do, South Korea. FU U. S. Army Engineer Research; Development Center, Construction Engineering Research Laboratory in Champaign, Illinois; National Science Foundation [EEC-9701785] FX This research was funded in part by the U. S. Army Engineer Research and Development Center, Construction Engineering Research Laboratory in Champaign, Illinois. The authors would also like to acknowledge the support of the Mid-America Earthquake Center, which is funded under National Science Foundation Grant EEC-9701785. Any results, findings, and conclusions reported herein are solely those of the authors and do not necessarily represent those of the sponsors. NR 16 TC 0 Z9 0 U1 0 U2 5 PU EARTHQUAKE ENGINEERING RESEARCH INST PI OAKLAND PA 499 14TH ST, STE 320, OAKLAND, CA 94612-1934 USA SN 8755-2930 J9 EARTHQ SPECTRA JI Earthq. Spectra PD NOV PY 2009 VL 25 IS 4 BP 803 EP 819 DI 10.1193/1.3240398 PG 17 WC Engineering, Civil; Engineering, Geological SC Engineering GA 513YH UT WOS:000271359600004 ER PT J AU Laoire, CO Plichta, E Hendrickson, M Mukerjee, S Abraham, KM AF Laoire, Cormac O. Plichta, Edward Hendrickson, Mary Mukerjee, Sanjeev Abraham, K. M. TI Electrochemical studies of ferrocene in a lithium ion conducting organic carbonate electrolyte SO ELECTROCHIMICA ACTA LA English DT Article DE Ferrocene oxidation; Non-aqueous electrolyte; Rotating disk electrode; Diffusion coefficient; Kinetics; Voltammetry; Lithium-ion battery ID OVERCHARGE PROTECTION; NONAQUEOUS SOLVENTS; CYCLIC VOLTAMMETRY; BATTERIES; POTENTIALS; ADDITIVES; DIFFUSION; BEHAVIOR; CELLS AB We carried out a detailed study of the kinetics of oxidation of ferrocene (Fc) to ferrocenium ion (Fc(+)) in the non-aqueous lithium ion conducting electrolyte composed of a solution of 1 M LiPF(6) in 1:1 EC:EMC solvent mixture. This study using cyclic (CV) and rotating disk electrode (RDE) voltammetry showed that the Fc(0)/Fc(+) redox couple is reversible in this highly concentrated electrolyte. The ferrocene and ferrocenium ion diffusion coefficients (D) were calculated from these results. In addition, the electron transfer rate constant (k(0)) and the exchange current density for the oxidation of ferrocene were determined. A comparison of the kinetic data obtained from the two electrochemical techniques appears to show that the data from the RDE experiments are more reliable because they are collected under strict mass transport control. A Tafel slope of c.a. 79 mV/decade and a transfer coefficient alpha of 0.3 obtained from analysis of the RDE data for ferrocene oxidation suggest that the structure of the activated complex is closer to that of the oxidized specie due to strong interactions with the carbonate solvents. The experiments reported here are relevant to the study of redox reagents for the chemical overcharge protection of Li-ion batteries. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Laoire, Cormac O.; Mukerjee, Sanjeev; Abraham, K. M.] Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA. [Plichta, Edward; Hendrickson, Mary] USA, CERDEC, Army Power Div, Ft Monmouth, NJ 07703 USA. RP Abraham, KM (reprint author), Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA. EM kmabraham@comcast.net FU US Army CERDEC [GTS-S-6-1-437] FX Financial support was provided by the US Army CERDEC through Subcontract No. GTS-S-6-1-437. NR 23 TC 26 Z9 26 U1 6 U2 48 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0013-4686 J9 ELECTROCHIM ACTA JI Electrochim. Acta PD NOV 1 PY 2009 VL 54 IS 26 BP 6560 EP 6564 DI 10.1016/j.electacta.2009.06.041 PG 5 WC Electrochemistry SC Electrochemistry GA 504VT UT WOS:000270646600062 ER PT J AU Song, JW Moon, SS Gu, SH Song, KJ Baek, LJ Kim, HC Kijek, T O'Guinn, ML Lee, JS Turell, MJ Klein, TA AF Song, Jin-Won Moon, Sung-Sil Gu, Se Hun Song, Ki-Joon Baek, Luck Ju Kim, Heung Chul Kijek, Todd O'Guinn, Monica L. Lee, John S. Turell, Michael J. Klein, Terry A. TI Hemorrhagic Fever with Renal Syndrome in 4 US Soldiers, South Korea, 2005 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID HANTAVIRUS; VIRUS AB Four US soldiers acquired hemorrhagic fever with renal syndrome while training near the Demilitarized Zone, South Korea, in 2005. Hantaan virus sequences were amplified by reverse transcription-PCR from patient serum samples and from lung tissues of striped field mice (Apodemus agrarius) captured at training sites. Epidemiologic investigations specified the ecology of possible sites of patient infection. C1 [Song, Jin-Won] Korea Univ, Dept Microbiol, Coll Med, Seoul 136705, South Korea. [Kim, Heung Chul; Kijek, Todd; Klein, Terry A.] 65th Med Brigade, Seoul, South Korea. [O'Guinn, Monica L.; Lee, John S.; Turell, Michael J.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Song, JW (reprint author), Korea Univ, Dept Microbiol, Coll Med, 126-1,5Ka, Seoul 136705, South Korea. EM jwsong@korea.ac.kr FU Armed Forces Health Surveillance Center; Global Emerging Infections Surveillance and Response System, Silver Spring, Maryland, USA; National Center for Medical Intelligence Center, Fort Detrick, Maryland, USA FX Dr Jin-Won Song is a professor of microbiology at Korea University. He has had a long-term interest in the global epizootiology and epidemiology of hantaviruses. NR 12 TC 14 Z9 14 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD NOV PY 2009 VL 15 IS 11 BP 1833 EP 1836 DI 10.3201/eid1511.090076 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 518ML UT WOS:000271696600024 PM 19891878 ER PT J AU Pascual, J McMann, LP Gallagher, T Pinsker, JE AF Pascual, James McMann, Leah P. Gallagher, Thomas Pinsker, Jordan E. TI AMBIGUOUS GENITALIA IN A NEWBORN WITH 45,X/46,X,IDIC(Y) OVOTESTICULAR DISORDER OF SEX DEVELOPMENT SO ENDOCRINE PRACTICE LA English DT Article ID Y-CHROMOSOME; GONADOBLASTOMA; DYSGENESIS; MANAGEMENT; DIAGNOSIS; TUMORS AB Objective: To discuss a case of ovotesticular disorder of sex development (DSD) with ambiguous genitalia, isodicentric Y sex chromosome mosaicism, and unique histopathologic findings. Methods: We report the clinical, laboratory, imaging, and operative findings, and we highlight the pertinent features of this case. Results of hormonal and genetic testing are reviewed, and histopathologic findings are illustrated. Results: A term newborn had ambiguous genitalia and was found to have an uncommon 45,X/46,X,idic(Y) karyotype. This infant had a 2-cm phallic structure, a penoscrotal hypospadias, a gonad easily palpable in the right scrotum, and a second gonad palpable high in the left inguinal canal. On ultrasonography, both gonads appeared as normal testicles, and no mullerian structures were identified. Testosterone and dihydrotestosterone levels were normal for a male neonate. After assessment of the patient at 2 months of age because of an incarcerated left inguinal hernia, both gonads were removed and were found to have both testicular and ovarian tissues spread throughout, with a fallopian tube on the left and an incipient juvenile granulosa cell tumor on the right. He was then diagnosed with ovotesticular DSD and continued to be raised as a boy. Conclusion: This male infant had undervirilization and an ovotesticular DSD. He had evidence of both ovarian and testicular tissues, in conjunction with apparent alterations in local mullerian inhibiting substance levels that allowed one fallopian tube to be preserved. The proportion of actively transcribed Y material in the chromosomes of patients with this karyotype may partially explain the variable phenotypes that can occur. (Endocr Pract. 2009;15:732-736) C1 [Pinsker, Jordan E.] Tripler Army Med Ctr, Dept Pediat, MCHK PE, Honolulu, HI 96859 USA. [McMann, Leah P.] Tripler Army Med Ctr, Dept Urol, Honolulu, HI 96859 USA. RP Pinsker, JE (reprint author), Tripler Army Med Ctr, Dept Pediat, MCHK PE, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM jordan.pinsker@us.army.mil OI Pinsker, Jordan/0000-0003-4080-9034 NR 19 TC 2 Z9 2 U1 0 U2 0 PU AMER ASSOC CLIN ENDOCRINOL PI JACKSONVILLE PA 1000 RIVERSIDE AVE, STE 205, JACKSONVILLE, FL 32204 USA SN 1530-891X J9 ENDOCR PRACT JI Endocr. Pract. PD NOV-DEC PY 2009 VL 15 IS 7 BP 732 EP 736 DI 10.4158/EP09060.CRR PG 5 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 542HJ UT WOS:000273483300011 PM 19546054 ER PT J AU Rodrigues, E Merchant-Borna, K Smith, K Proctor, S McClean, M AF Rodrigues, Ema Merchant-Borna, Kian Smith, Kristen Proctor, Susan McClean, Michael TI Characterization of Jet Fuel Inhalation Exposure and Urinary Metabolites in US Air Force Personnel SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Rodrigues, Ema] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. [Merchant-Borna, Kian; Smith, Kristen; McClean, Michael] Boston Univ, Sch Publ Hlth, Boston, MA USA. [Smith, Kristen; Proctor, Susan] USA, Res Inst Environm Med, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S60 EP S60 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874100147 ER PT J AU Smith, K Proctor, S McClean, M AF Smith, Kristen Proctor, Susan McClean, Michael TI Relationships Between Inhalation Exposure, Urinary and End Exhaled-Breath Biomarkers Among Jet Fuel Exposed Air Force Personnel SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Smith, Kristen; McClean, Michael] Boston Univ, Sch Publ Hlth, Boston, MA USA. [Smith, Kristen; Proctor, Susan] USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S167 EP S167 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874101150 ER PT J AU Furtado, MD Lumley, L Moffett, M Pak, T Addis, M Robertson, B Lichtenstein, S Schwartz, J Schultz, M Rossetti, F Yourick, D AF Furtado, Marcio D. Lumley, L. Moffett, M. Pak, T. Addis, M. Robertson, B. Lichtenstein, S. Schwartz, J. Schultz, M. Rossetti, F. Yourick, D. TI EFFECTS OF REPEATED ADMINISTRATION OF VALPROIC ACID AFTER SEIZURES INDUCED BY ORGANOPHOSPHOROUS COMPOUNDS IN SPRAGUE-DAWLEY RATS SO EPILEPSIA LA English DT Meeting Abstract CT 63rd Annual Meeting of the American-Epilepsy-Society CY DEC 04-08, 2009 CL Boston, MA SP Amer Epilepsy Soc C1 [Furtado, Marcio D.; Pak, T.; Addis, M.; Robertson, B.; Lichtenstein, S.; Rossetti, F.; Yourick, D.] Walter Reed Army Inst Res, Brain Dysfunct & Blast Injury Div, Silver Spring, MD USA. [Lumley, L.; Moffett, M.; Schwartz, J.; Schultz, M.] USA, Med Res Inst Chem Def, Edgewood, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0013-9580 J9 EPILEPSIA JI Epilepsia PD NOV PY 2009 VL 50 BP 366 EP 367 PG 2 WC Clinical Neurology SC Neurosciences & Neurology GA 503PP UT WOS:000270550500817 ER PT J AU Bi, SG Das, R Zelazowska, E Mani, S Neill, R Coleman, GD Yang, DC Hammamieh, R Shupp, JW Jett, M AF Bi, Shuguang Das, Rina Zelazowska, Elzbieta Mani, Sachin Neill, Roger Coleman, Gary D. Yang, David C. Hammamieh, Rasha Shupp, Jeffrey W. Jett, Marti TI The Cellular and Molecular Immune Response of the Weanling Piglet to Staphylococcal Enterotoxin B SO EXPERIMENTAL BIOLOGY AND MEDICINE LA English DT Article DE superantigen; SEB; shock; animal model; toxic shock ID TOXIC-SHOCK-SYNDROME; 3-DIMENSIONAL STRUCTURE; T-LYMPHOCYTES; EMETIC ACTION; CELLS; SUPERANTIGENS; MICE; INDUCTION; MECHANISMS; MONKEYS AB Staphylococcal enterotoxin B (SEB) is a biothreat agent, etiologic agent of food poisoning, and potent inducer of toxic shock syndrome. This heat-stable exoprotein is thought to act as a superantigen to induce T cell-specific pathology. Most animal models do not accurately map the clinical syndrome of human SEB exposure. Previously, we have demonstrated the utility of the weanling piglet model of SEB intoxication. Here, we analyze gross and histopathologic specimens from lymphoid tissue of these animals. Hematological testing was completed to observe changes in circulating leukocytes. Further, these leukocytes were differentiated and the subsets were subsequently analyzed using flow cytometry. Cytokine mRNA was quantified in lymphoid tissue and peripheral blood cells and compared to actual protein concentration using ELISA. The mRNA expression levels for several cell markers implicated in T and B cell differentiation were quantified and compared to control animals, as were levels for apoptosis-related genes. Lymphadenopathy was constantly seen post mortem. SEB-exposed animals had a leukocytosis which increased linearly over the time course. Monocyte levels increased over time, while lymphocyte levels peaked at 6h and then returned to baseline. Most cytokines had mRNA levels that were upregulated after exposure. Detection of serum cytokine changes was accomplished; however, these patterns did not always follow those seen in the differentially expressed genes. Both pro- and anti-apoptotic genes were differentially expressed in exposed animals. This paper reports, for the first time, the immunological findings in the weanling piglet model of SEB intoxication. From this work it is clear that there is not one absolute cell-mediated pathway contributing to the pathology these animals exhibit as a result of SEB exposure. Exp Biol Med 234:1305-1315, 2009 C1 [Bi, Shuguang; Das, Rina; Zelazowska, Elzbieta; Mani, Sachin; Neill, Roger; Coleman, Gary D.; Hammamieh, Rasha; Shupp, Jeffrey W.; Jett, Marti] Walter Reed Army Inst Res, Dept Mol Pathol, Div Pathol, Silver Spring, MD 20910 USA. [Bi, Shuguang; Yang, David C.; Jett, Marti] Georgetown Univ, Dept Chem, Washington, DC 20057 USA. RP Jett, M (reprint author), Walter Reed Army Inst Res, Dept Mol Pathol, Div Pathol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Marti.jett@army.us.mil RI Yang, David/A-7294-2009 FU Defense Advanced Research Projects Agency (DARPA) FX Funding for this study was provided by the Defense Advanced Research Projects Agency (DARPA). NR 40 TC 6 Z9 6 U1 0 U2 3 PU SOC EXPERIMENTAL BIOLOGY MEDICINE PI MAYWOOD PA 195 WEST SPRING VALLEY AVE, MAYWOOD, NJ 07607-1727 USA SN 1535-3702 J9 EXP BIOL MED JI Exp. Biol. Med. PD NOV PY 2009 VL 234 IS 11 BP 1305 EP 1315 DI 10.3181/0901-RM-2 PG 11 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 536BX UT WOS:000273018300008 PM 19855072 ER PT J AU Brooks, TC Burlingame, M Burk, M Tortorice, K Dong, D Glassman, PA Lynch, JA Good, CB Rickman, HS Claborn, M Appleman, D Jones, W Shaverd, L AF Brooks, Traci C. Burlingame, Mark Burk, Muriel Tortorice, Kathy Dong, Diane Glassman, Peter A. Lynch, Jennie A. Good, Chester B. Rickman, Holly S. Claborn, Melanie Appleman, Duva Jones, William Shaverd, Lanita TI Travoprost A prostaglandin analogue for the treatment of glaucoma SO FORMULARY LA English DT Article ID OPEN-ANGLE GLAUCOMA; LATANOPROST AB In August 2003, the US Department of Veterans Affairs (VA) awarded a contract for prostaglandin ophthalmic agents with travoprost as the agent of choice. Although there was no national mandate to switch patients from existing therapy, many VA facilities had agreements from their local ophthalmology and optometry departments to conduct a therapeutic interchange of patients from existing prostaglandins (eg, latanoprost) to travoprost. The primary purpose of this report is to describe the experience of conversion to travoprost after this contract. Medical records of converted patients were evaluated for change in intraocular pressure (IOP), change in visual field, adverse events, and whether or not a change back to the original therapy or alternative therapy was required. Of 578 patients evaluated, most (84%) had been using latanoprost before the conversion. After conversion, mean IOP was significantly reduced by 1.64 +/- 4.95 mm Hg (P<.0001). Of 188 patients with documented visual field assessment, 89.9% had no change or improvement in visual field after conversion. Adverse events occurred in 44 (7.6%) patients, with hyperemia occurring in 13 (2.2%) patients. Discontinuation of travoprost was attributed to an adverse event in 29 (5.0%) patients and attributed to ineffectiveness in 17 (2.9%) patients. Adverse drug event rates were significantly less than those reported in the literature. Travoprost was effective and well tolerated in most patients after therapeutic interchange. This evaluation provides additional information regarding outcomes associated with the therapeutic interchange. (Formulary. 2009; 44:322-328.) C1 [Brooks, Traci C.] Womack Army Med Ctr, Ft Bragg, NC USA. [Brooks, Traci C.; Burlingame, Mark] N Florida S Georgia Vet Hlth Syst, Gainesville, FL USA. [Burk, Muriel; Dong, Diane] VA Ctr Medicat Safety, VACO PBM Serv, Hines, IL USA. [Tortorice, Kathy] VACO Pharm Benefits Management Serv, Hines, IL USA. [Glassman, Peter A.] Univ Calif Los Angeles, David Geffen Sch Med, VA Greater Los Angeles Healthcare Syst, Los Angeles, CA 90095 USA. [Lynch, Jennie A.] VISN 2 VA Healthcare Network Upstate New York, Syracuse, NY USA. [Good, Chester B.] Univ Pittsburgh, Sch Med, VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. [Good, Chester B.] Univ Pittsburgh, Sch Pharm, Pittsburgh, PA USA. [Rickman, Holly S.; Shaverd, Lanita] Cent Arkansas Vet Healthcare Syst, Little Rock, AR USA. [Claborn, Melanie] Univ Arkansas Med Sci, Vet Healthcare Syst Ozarks, Fayetteville, AR USA. [Appleman, Duva] Univ Calif, No Calif Vet Healthcare Syst, Davis Mather, CA USA. [Jones, William] SW Consolidated Mail Outpatient Pharm, Tucson, AZ USA. [Jones, William] VACO PBM Serv, Tucson, AZ USA. RP Brooks, TC (reprint author), Womack Army Med Ctr, Ft Bragg, NC USA. NR 8 TC 4 Z9 4 U1 0 U2 0 PU ADVANSTAR COMMUNICATIONS INC PI WOODLAND HILLS PA 6200 CANOGA AVE, 2ND FLR, WOODLAND HILLS, CA 91367 USA SN 1082-801X J9 FORMULARY JI Formulary PD NOV PY 2009 VL 44 IS 11 BP 322 EP 328 PG 9 GA 521PK UT WOS:000271934000001 ER PT J AU Ogundipe, A Pavlov, J Braida, W Koutsospyros, A Sen, G Christodoulatos, C O'Connor, G AF Ogundipe, A. Pavlov, J. Braida, W. Koutsospyros, A. Sen, G. Christodoulatos, C. O'Connor, G. TI EVALUATION OF ANALYTICAL METHODS TO ADDRESS TUNGSTEN SPECIATION SO GLOBAL NEST JOURNAL LA English DT Article; Proceedings Paper CT 9th International Conference on Protection and Restoration of the Environment CY JUN 30-JUL 03, 2008 CL Kefalonia, GREECE DE Tungsten speciation; Environmental; LDI-TOF; Raman ID CONDENSATION; ISOPOLY AB Tungsten in solution may exist as a wide variety of species depending on concentration, pH, and aging time. Despite a substantial number of studies on this topic, the speciation of tungsten in aqueous solutions is still not completely understood. To address issues of fate, transport and potential bioavailability, it is necessary to be able to assess the speciation of tungsten in environmental systems. This study investigates the use of Laser Desorption/Ionization mass spectrometry combined with a Time-of-Flight mass analyzer (LDI-TOF) as well as Raman spectroscopy as potential techniques in speciation studies. Raman spectroscopy has been successful in identifying the dominant species under a narrow range of conditions. The ultimate goal is to extend the range of conditions and concentrations while also identifying subordinate species. C1 [Ogundipe, A.; Pavlov, J.; Braida, W.; Sen, G.; Christodoulatos, C.] Stevens Inst Technol, Ctr Environm Syst, Hoboken, NJ 07030 USA. [Koutsospyros, A.] Univ New Haven, West Haven, CT 06516 USA. [O'Connor, G.] USA, Demilitarizat & Environm Technol Div, Picatinny Arsenal, NJ 07806 USA. RP Braida, W (reprint author), Stevens Inst Technol, Ctr Environm Syst, Hoboken, NJ 07030 USA. EM wbraida@stevens.edu NR 15 TC 6 Z9 6 U1 1 U2 10 PU GLOBAL NETWORK ENVIRONMENTAL SCIENCE & TECHNOLOGY PI ATHENS PA 30 VOULGAROKTONOU STR, ATHENS, GR 114 72, GREECE SN 1790-7632 J9 GLOBAL NEST J JI Glob. Nest. J. PD NOV PY 2009 VL 11 IS 3 SI SI BP 308 EP 317 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA 544YN UT WOS:000273697600008 ER PT J AU Harrison, SA Neuschwander-Tetri, BA AF Harrison, S. A. Neuschwander-Tetri, B. A. TI Applicability of BARD score to Japanese patients with NAFLD Authors' reply SO GUT LA English DT Letter C1 [Harrison, S. A.] Brooke Army Med Ctr, Div Gastroenterol & Hepatol, San Antonio, TX USA. [Neuschwander-Tetri, B. A.] St Louis Univ, Dept Internal Med, St Louis, MO 63103 USA. RP Harrison, SA (reprint author), 3841 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Stephen.Harrison@amedd.army.mil NR 2 TC 0 Z9 0 U1 0 U2 0 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0017-5749 J9 GUT JI Gut PD NOV PY 2009 VL 58 IS 11 BP 1567 EP 1567 DI 10.1136/gut.2009.186924 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 507JG UT WOS:000270848700026 ER PT J AU Moore, ML Dewey, WS Richard, RL AF Moore, Merilyn L. Dewey, William S. Richard, Reginald L. TI Rehabilitation of the Burned Hand SO HAND CLINICS LA English DT Article DE Burn hand deformities; Burn scar contracture; Burn rehabilitation; Splinting the burned hand; Range of motion; Hand therapy; Hand function ID HETEROTOPIC OSSIFICATION; PHYSICAL THERAPY; INJURY; MANAGEMENT; EDEMA; CONTRACTURES; EXPERIENCE; EXCISION AB Successful outcomes following hand burn injury require an understanding of the rehabilitation needs of the patient. Rehabilitation of hand burns begins on admission, and each patient requires a specific plan for range of motion and/or immobilization, functional activities, and modalities. The rehabilitation care plan typically evolves during the acute care period and during the months following injury. C1 [Moore, Merilyn L.] Univ Washington, Rehabil Therapies & Burn Plast Clin, Burn Ctr, Harborview Med Ctr, Seattle, WA 98104 USA. [Dewey, William S.; Richard, Reginald L.] USA, Inst Surg Res SDEWEY, Army Burn Ctr, Ft Sam Houston, TX 78234 USA. RP Moore, ML (reprint author), Univ Washington, Rehabil Therapies & Burn Plast Clin, Burn Ctr, Harborview Med Ctr, Box 359835,325 9th Ave, Seattle, WA 98104 USA. EM mlmoore@u.washington.edu NR 50 TC 6 Z9 7 U1 2 U2 10 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0749-0712 EI 1558-1969 J9 HAND CLIN JI Hand Clin. PD NOV PY 2009 VL 25 IS 4 BP 529 EP + DI 10.1016/j.hcl.2009.06.005 PG 14 WC Orthopedics SC Orthopedics GA 510MJ UT WOS:000271092300008 PM 19801125 ER PT J AU Ghogho, M Whitworth, T Swami, A McLernon, D AF Ghogho, Mounir Whitworth, Tim Swami, Ananthram McLernon, Des TI Full-Rank and Rank-Deficient Precoding Schemes for Single-Carrier Block Transmissions SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article DE Channel estimation; cyclic prefix; precoding; single carrier; superimposed training ID CHANNEL ESTIMATION; OFDM AB In block-mode transmission, inserting a cyclic prefix (CP) between two consecutive blocks provides an efficient way of removing interblock interference and simplifies equalization of frequency-selective channels at the receiver. Here, we address optimal training design for channel estimation in such systems. Our investigations focus on affine precoding schemes. In designing the precoder, least squares channel estimation is constrained to be decoupled from symbol detection, which results in orthogonal precoding schemes. If the precoding matrix is full-rank, the data rate (or bandwidth) has to be traded off to accommodate training. We propose a full-rank orthogonal single-carrier (FROSC) precoding with a low peak-to-average power ratio. Then, in order to improve bandwidth efficiency, we propose a rank deficient orthogonal single carrier (DROSC) precoding scheme. Symbol recovery is still possible thanks to the finite alphabet property of the data symbols. C1 [Ghogho, Mounir; Whitworth, Tim; McLernon, Des] Univ Leeds, Sch Elect & Elect Engn, Leeds LS2 9JT, W Yorkshire, England. [Swami, Ananthram] USA, Res Lab, Adelphi, MD 20783 USA. RP Ghogho, M (reprint author), Univ Leeds, Sch Elect & Elect Engn, Leeds LS2 9JT, W Yorkshire, England. EM m.ghogho@leeds.ac.uk; eentcw@leeds.ac.uk; a.swami@ieee.org; d.c.mclernon@leeds.ac.uk NR 19 TC 6 Z9 6 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1053-587X EI 1941-0476 J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD NOV PY 2009 VL 57 IS 11 BP 4433 EP 4442 DI 10.1109/TSP.2009.2025153 PG 10 WC Engineering, Electrical & Electronic SC Engineering GA 506BG UT WOS:000270747200024 ER PT J AU Huddleston, SH Brown, DE AF Huddleston, Samuel H. Brown, Donald E. TI A Statistical Threat Assessment SO IEEE TRANSACTIONS ON SYSTEMS MAN AND CYBERNETICS PART A-SYSTEMS AND HUMANS LA English DT Article DE Crime analysis; multilevel modeling; predictive analysis; spatial data ID PREDICTION; MODELS AB Criminal gangs, insurgent groups, and terror networks demonstrate observable preferences in selecting the sites where they commit their crimes. Accordingly, police departments, military organizations, and intelligence agencies seek to learn these preferences and identify locations with a high probability of experiencing the particular event of interest in the near future. Often, such agencies are keen not just to predict the spatial pattern of future events but even more importantly to conduct threat assessments of particular criminal gangs or insurgent groups. These threat assessments include identifying where each of the various groups presents the greatest threat to the community, what the most likely targets are for each criminal group, what makes one location more likely to experience an attack than another, and how to most efficiently allocate resources to address the specific threats to the community. Previous research has demonstrated that applying multivariate prediction models to relate features in an area to the occurrence of crimes offers an improvement in predictive performance over traditional methods of hot-spot analysis. This paper introduces the application of multilevel modeling to these multivariate spatial choice models, demonstrating that it is possible to significantly improve the predictive performance of the spatial choice models for individual groups and leverage that information to provide improved threat assessments of the criminal elements in a given geographic area. C1 [Huddleston, Samuel H.] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. [Brown, Donald E.] Univ Virginia, Dept Syst & Informat Engn, Charlottesville, VA 22903 USA. RP Huddleston, SH (reprint author), US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. EM samuel.huddleston@usma.edu NR 19 TC 4 Z9 4 U1 0 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1083-4427 EI 1558-2426 J9 IEEE T SYST MAN CY A JI IEEE Trans. Syst. Man Cybern. Paart A-Syst. Hum. PD NOV PY 2009 VL 39 IS 6 BP 1307 EP 1315 DI 10.1109/TSMCA.2009.2027611 PG 9 WC Computer Science, Cybernetics; Computer Science, Theory & Methods SC Computer Science GA 508QI UT WOS:000270947600015 ER PT J AU Park, J Chen, ZH Kiliaris, L Kuang, ML Masrur, MA Phillips, AM Murphey, YL AF Park, Jungme Chen, Zhihang Kiliaris, Leonidas Kuang, Ming L. Masrur, M. Abul Phillips, Anthony M. Murphey, Yi Lu TI Intelligent Vehicle Power Control Based on Machine Learning of Optimal Control Parameters and Prediction of Road Type and Traffic Congestion SO IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY LA English DT Article DE Fuel economy; machine learning; road type and traffic congestion (RT&TC) level prediction; vehicle power management ID PARALLEL HYBRID VEHICLE; ENERGY MANAGEMENT AGENT; STRATEGIES AB Previous research has shown that current driving conditions and driving style have a strong influence over a vehicle's fuel consumption and emissions. This paper presents a methodology for inferring road type and traffic congestion (RT&TC) levels from available onboard vehicle data and then using this information for improved vehicle power management. A machine-learning algorithm has been developed to learn the critical knowledge about fuel efficiency on 11 facility-specific drive cycles representing different road types and traffic congestion levels, as well as a neural learning algorithm for the training of a neural network to predict the RT&TC level. An online University of Michigan-Dearborn intelligent power controller (UMD_IPC) applies this knowledge to real-time vehicle power control to achieve improved fuel efficiency. UMD_IPC has been fully implemented in a conventional (non-hybrid) vehicle model in the powertrain systems analysis toolkit (PSAT) environment. Simulations conducted on the standard drive cycles provided by the PSAT show that the performance of the UMD_IPC algorithm is very close to the offline controller that is generated using a dynamic programming optimization approach. Furthermore, UMD_IPC gives improved fuel consumption in a conventional vehicle, alternating neither the vehicle structure nor its components. C1 [Park, Jungme; Chen, Zhihang; Kiliaris, Leonidas; Murphey, Yi Lu] Univ Michigan, Dept Elect & Comp Engn, Dearborn, MI 48128 USA. [Kuang, Ming L.; Phillips, Anthony M.] Ford Motor Co, Dearborn, MI 48120 USA. [Masrur, M. Abul] USA, RDECOM TARDEC, Warren, MI 49307 USA. RP Park, J (reprint author), Univ Michigan, Dept Elect & Comp Engn, Dearborn, MI 48128 USA. EM yilu@umich.edu FU State of Michigan through the 21st Jobs Fund; Institute of Advanced Vehicle Systems, University of Michigan-Dearborn [06-1-p1-0727] FX This work was supported in part by the State of Michigan through the 21st Jobs Fund under a grant and in part by the Institute of Advanced Vehicle Systems, University of Michigan-Dearborn, under Grant 06-1-p1-0727. The review of this paper was coordinated by Dr. M. S. Ahmed. NR 24 TC 35 Z9 38 U1 4 U2 17 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9545 J9 IEEE T VEH TECHNOL JI IEEE Trans. Veh. Technol. PD NOV PY 2009 VL 58 IS 9 BP 4741 EP 4756 DI 10.1109/TVT.2009.2027710 PG 16 WC Engineering, Electrical & Electronic; Telecommunications; Transportation Science & Technology SC Engineering; Telecommunications; Transportation GA 518GW UT WOS:000271679800005 ER PT J AU Brogan, JW AF Brogan, Jesse W. TI Restoring efficiency to health SO INDUSTRIAL ENGINEER LA English DT Article C1 [Brogan, Jesse W.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Brogan, JW (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INST INDUSTRIAL ENGINEERS PI NORCROSS PA 3577 PARKWAY LANE, STE 200, NORCROSS, GA 30092 USA SN 1542-894X J9 IND ENG JI Ind. Eng PD NOV PY 2009 VL 41 IS 11 BP 33 EP 37 PG 5 WC Engineering, Industrial SC Engineering GA V18MV UT WOS:000208009800015 ER PT J AU Bandara, SV AF Bandara, Sumith V. TI Detector and readout performance goals for quantum well and strained layer superlattice focal plane arrays imaging under tactical and strategic backgrounds SO INFRARED PHYSICS & TECHNOLOGY LA English DT Article; Proceedings Paper CT International Conference on Quantum Structure Infrared Photodetector CY JAN 18-23, 2009 CL Yosemite, CA SP NASA, Jet Propuls Lab, NASA, AF Res Lab, NASA, Army Res Lab, NASA, Defense Adv Res Projects Agcy, NASA, Missile Defense Agcy, Calif Inst Technol, Georgia Inst Technol, FLIR, QWIPT Technol, QmagiQ Wafer Technol DE Infrared; Focal plane arrays; Strained layer superlattice; Quantum well AB Advancements in III-V semiconductor based, Quantum-well infrared photodetector (QWIP) and Type-II Strained-Layer Superlattice detector (T2SLS) technologies have yielded highly uniform, large-format long-wavelength infrared (LWIR) QWIP FPAs and high quantum efficiency (QE), small format, LWIR T2SLS FPAs. In this article, we have analyzed the QWIP and T2SLS detector level performance requirements and readout integrated circuit (ROIC) noise levels for several staring array long-wavelength infrared (LWIR) imaging applications at various background levels. As a result of lower absorption QE and less than unity photoconductive gain, QWIP FPAs are appropriate for high background tactical applications. However, if the application restricts the integration time, QWIP EPA performance may be limited by the read noise of the ROIC. Rapid progress in T2SLS detector material has already demonstrated LWIR detectors with sufficient performance for tactical applications and potential for strategic applications. However, significant research is needed to suppress surface leakage currents in order to reproduce performances at pixel levels of T2SLS FPAs. Published by Elsevier B.V. C1 USA, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. RP Bandara, SV (reprint author), USA, RDECOM CERDEC NVESD, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. EM smith.bandara@us.army.mil NR 19 TC 1 Z9 1 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1350-4495 J9 INFRARED PHYS TECHN JI Infrared Phys. Technol. PD NOV PY 2009 VL 52 IS 6 BP 299 EP 303 DI 10.1016/j.infrared.2009.05.032 PG 5 WC Instruments & Instrumentation; Optics; Physics, Applied SC Instruments & Instrumentation; Optics; Physics GA 539GB UT WOS:000273240700019 ER PT J AU Tidrow, MZ AF Tidrow, Meimei Z. TI Type II strained layer superlattice: A potential future IR solution SO INFRARED PHYSICS & TECHNOLOGY LA English DT Article; Proceedings Paper CT International Conference on Quantum Structure Infrared Photodetector CY JAN 18-23, 2009 CL Yosemite, CA SP NASA, Jet Propuls Lab, NASA, AF Res Lab, NASA, Army Res Lab, NASA, Defense Adv Res Projects Agcy, NASA, Missile Defense Agcy, Calif Inst Technol, Georgia Inst Technol, FLIR, QWIPT Technol, QmagiQ Wafer Technol DE Infrared photodetectors; Type II strained layer superlattice; HgCdTe; Quantum well infrared photodetectors; Minority carrier lifetime AB Type II strained layer superlattice (SLS) has been making tremendous progress in the past few years funded by the Missile Defense Agency Advanced Technology Directorate (MDA/DV) under the Passive EO/IR Program. SLS has shown great potential as a future solution for infrared military systems. in this presentation, the most recent progress in SLS development will be presented. The presentation will also discuss the comparison of SLS with mercury-cadmium-telluride (HgCdTe) using Rule 07, SLS minority carrier lifetime issues, and future directions. Published by Elsevier B.V. C1 USA, Night Vis Elect & Sensor Directorate, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. RP Tidrow, MZ (reprint author), USA, Night Vis Elect & Sensor Directorate, RDECOM CERDEC NVESD, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. EM meimei.tidrow@mda.mil NR 10 TC 23 Z9 23 U1 1 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1350-4495 J9 INFRARED PHYS TECHN JI Infrared Phys. Technol. PD NOV PY 2009 VL 52 IS 6 BP 322 EP 325 DI 10.1016/j.infrared.2009.05.028 PG 4 WC Instruments & Instrumentation; Optics; Physics, Applied SC Instruments & Instrumentation; Optics; Physics GA 539GB UT WOS:000273240700023 ER PT J AU Canedy, CL Aifer, EH Warner, JH Vurgaftman, I Jackson, EM Tischler, JG Powell, SP Olver, K Meyer, JR Tennant, WE AF Canedy, C. L. Aifer, E. H. Warner, J. H. Vurgaftman, I. Jackson, E. M. Tischler, J. G. Powell, S. P. Olver, K. Meyer, J. R. Tennant, W. E. TI Controlling dark current in type-II superlattice photodiodes SO INFRARED PHYSICS & TECHNOLOGY LA English DT Article; Proceedings Paper CT International Conference on Quantum Structure Infrared Photodetector CY JAN 18-23, 2009 CL Yosemite, CA SP NASA, Jet Propuls Lab, NASA, AF Res Lab, NASA, Army Res Lab, NASA, Defense Adv Res Projects Agcy, NASA, Missile Defense Agcy, Calif Inst Technol, Georgia Inst Technol, FLIR, QWIPT Technol, QmagiQ Wafer Technol DE Semiconductor superlattices; Strained layer superlattice; GaSb; III-V semiconductors; IR detector; Photodiode AB Limiting the defect-mediated dark currents in type-II superlattice (T2SL) IR photodiodes remains the key challenge to focal plane arrays (FPAs) based on this material system. In spite of its larger effective mass to suppress tunneling and more than an order of magnitude longer Auger lifetime, the T2SL photodiode performance still lags behind that of the incumbent HgCdTe-based technology. The tunneling and generation-recombination currents can be strongly suppressed by employing a "W" T2SL structure and gradually increasing the energy gap in the depletion region. For maximum quantum efficiency, this graded-gap geometry is combined in a hybrid structure with two-constituent T2SL absorbers that exhibit roughly twice the diffusion length of the "W" structure. Finally. if the etch used to isolate neighboring pixels is stopped just beyond the junction in the graded-gap device, narrow-gap regions are not exposed and the total sidewall area is reduced by a factor of 20. We have combined all of these approaches to produce a 10.5 mu m cutoff FPA with diffusion-limited performance and noise-equivalent differential temperature (NEDT) of 35 mK at 70 K. Published by Elsevier B.V. C1 [Canedy, C. L.; Aifer, E. H.; Warner, J. H.; Vurgaftman, I.; Jackson, E. M.; Tischler, J. G.; Meyer, J. R.] USN, Res Lab, Washington, DC 20375 USA. [Powell, S. P.] N Carolina State Univ, Raleigh, NC 27695 USA. [Olver, K.] USA, Res Lab, Adelphi, MD 20783 USA. [Tennant, W. E.] Teledyne Imaging Sensors, Camarillo, CA 93212 USA. RP Canedy, CL (reprint author), USN, Res Lab, Washington, DC 20375 USA. EM canedy@sisyphus.nrl.navy.mil NR 16 TC 26 Z9 26 U1 1 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1350-4495 J9 INFRARED PHYS TECHN JI Infrared Phys. Technol. PD NOV PY 2009 VL 52 IS 6 BP 326 EP 334 DI 10.1016/j.infrared.2009.09.004 PG 9 WC Instruments & Instrumentation; Optics; Physics, Applied SC Instruments & Instrumentation; Optics; Physics GA 539GB UT WOS:000273240700024 ER PT J AU Choi, KK Forrai, DP Endres, D Sun, J Pinsukanjana, P Devitt, JW AF Choi, K. K. Forrai, D. P. Endres, D. Sun, J. Pinsukanjana, P. Devitt, J. W. TI C-QWIP focal plane arrays SO INFRARED PHYSICS & TECHNOLOGY LA English DT Article; Proceedings Paper CT International Conference on Quantum Structure Infrared Photodetector CY JAN 18-23, 2009 CL Yosemite, CA SP NASA, Jet Propuls Lab, NASA, AF Res Lab, NASA, Army Res Lab, NASA, Defense Adv Res Projects Agcy, NASA, Missile Defense Agcy, Calif Inst Technol, Georgia Inst Technol, FLIR, QWIPT Technol, QmagiQ Wafer Technol DE QWIP; FPA; NE Delta T AB We have been developing corrugated quantum well infrared photodetector (C-QWIP) technology for long wavelength applications. A number of large format 1024 x 1024 C-QWIP focal plane arrays (FPAs) have been demonstrated. In this paper, we will provide a detailed analysis on the FPA performance in terms of quantum efficiency eta and compare it with a detector model. We found excellent agreement between theory and experiment when both the material parameters and the pixel geometry were taken into account. By changing the number of quantum wells, doping density, spectral bandwidth and pixel size, a range of eta from 13% to 37% was obtained. This range of eta combined with the wide spectral width. enables C-QWIPs to be operated at a high speed. For example, model analysis shows that a C-QWIP FPA with 10.7 mu m cutoff and 25 mu m pitch will have a thermal sensitivity of 16 mK at 2 ms integration time with f/2 optics in the presence of 900 readout noise electrons. Published by Elsevier B.V. C1 [Choi, K. K.; Sun, J.] USA, Res Lab, Adelphi, MD 20783 USA. [Forrai, D. P.; Endres, D.; Devitt, J. W.] L3 Cincinnati Elect, Mason, OH 45040 USA. [Pinsukanjana, P.] Intelligent Epitaxy Technol, Richardson, TX 75081 USA. RP Choi, KK (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM kchoi@arl.army.mil RI Choi, Kwong-Kit/K-9205-2013 NR 6 TC 0 Z9 0 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1350-4495 J9 INFRARED PHYS TECHN JI Infrared Phys. Technol. PD NOV PY 2009 VL 52 IS 6 BP 364 EP 370 DI 10.1016/j.infrared.2009.05.021 PG 7 WC Instruments & Instrumentation; Optics; Physics, Applied SC Instruments & Instrumentation; Optics; Physics GA 539GB UT WOS:000273240700031 ER PT J AU Zheng, L Tidrow, M AF Zheng, Lucy Tidrow, Meimei TI Analyses of infrared focal plane array figure of merit and its impact on sensor system trades SO INFRARED PHYSICS & TECHNOLOGY LA English DT Article; Proceedings Paper CT International Conference on Quantum Structure Infrared Photodetector CY JAN 18-23, 2009 CL Yosemite, CA SP NASA, Jet Propuls Lab, NASA, AF Res Lab, NASA, Army Res Lab, NASA, Defense Adv Res Projects Agcy, NASA, Missile Defense Agcy, Calif Inst Technol, Georgia Inst Technol, FLIR, QWIPT Technol, QmagiQ Wafer Technol DE Infrared focal plane array; IRFPA; Residual nonuniformity; RNU; Space-based surveillance; Superlattice material AB The performance of infrared focal plane arrays (IRFPAs) is usually described by a set of figures of merit and operating parameters. They include FPA format, pixel pitch, operating temperature, cut-on and cutoff wavelengths, median detectivity. uniformity, and integration time. This article examines the promise of superlattice infrared materials and how the improved FPA figure of merit affects sensor system performance as measured by range, update rate, size, power, and cost. A simple analysis shows that for space-based surveillance, the system cost, as measured by the number of hosting satellites, may be decreased substantially by using detector arrays with large array size and longer detection range. It also shows that to make long-wavelength superlattice IRFPAs useful for future space applications, the residual nonuniformity must be improved. (C) 2009 Elsevier B.V. All rights reserved. C1 [Zheng, Lucy] Inst Def Anal, Alexandria, VA 22311 USA. [Tidrow, Meimei] USA, CERDEC, NVESD, Ft Belvoir, VA 22060 USA. RP Zheng, L (reprint author), Inst Def Anal, 4850 Mark Ctr Dr, Alexandria, VA 22311 USA. EM lzheng@ida.org NR 7 TC 3 Z9 3 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1350-4495 J9 INFRARED PHYS TECHN JI Infrared Phys. Technol. PD NOV PY 2009 VL 52 IS 6 BP 408 EP 411 DI 10.1016/j.infrared.2009.08.001 PG 4 WC Instruments & Instrumentation; Optics; Physics, Applied SC Instruments & Instrumentation; Optics; Physics GA 539GB UT WOS:000273240700039 ER PT J AU Jhabvala, M Reuter, D Choi, K Jhabvala, C Sundaram, M AF Jhabvala, M. Reuter, D. Choi, K. Jhabvala, C. Sundaram, M. TI QWIP-based thermal infrared sensor for the Landsat Data Continuity Mission SO INFRARED PHYSICS & TECHNOLOGY LA English DT Article; Proceedings Paper CT International Conference on Quantum Structure Infrared Photodetector CY JAN 18-23, 2009 CL Yosemite, CA SP NASA, Jet Propuls Lab, NASA, AF Res Lab, NASA, Army Res Lab, NASA, Defense Adv Res Projects Agcy, NASA, Missile Defense Agcy, Calif Inst Technol, Georgia Inst Technol, FLIR, QWIPT Technol, QmagiQ Wafer Technol DE QWIP; Infrared detectors; Landsat; Quantum well structures AB The thermal infrared sensor (TIRS) is a QWIP based instrument intended to supplement the Operational Land Imager (OLI) for the Landsat Data Continuity Mission (LDCM) [See Landsat project description at: http://landsathandbook.gsfc.nasa.gov/handbook/handbook-htmis/chapterl/chapterl.html, [1]. The LDCM is planned to be launched in late 2012 and will continue the 35 year legacy of the Landsat program as Landsat 7 degrades. The LDCM is a joint NASA-US Geological Survey (USGS) mission. The TIRS instrument is a far infrared imager operating in the push broom mode with two IR channels: 10.8 mu m and 12 mu m. The focal plane will contain three 640 x 512 QWIP arrays mounted on a silicon substrate. The readout integrated circuit (ROIC) is intended to be the Indigo 9803. The focal plane operating temperature will be 43 K (nominally). Bandpass filters will define the precise spectral response of the focal plane. Two QWIP designs will be pursued, the corrugated structure and the grating structure. NASA/Goddard, the Army Research Lab and QmagiQ will work closely together to obtain the suite of arrays that will best meet the mission requirements (primarily adequate conversion efficiency at the required wavelengths). This paper will describe the design and fabrication of the TIRS instrument with particular emphasis on the QWIP detectors. The QWIP parameters that are driving the mission requirements include spectral response, dark current, conversion efficiency, read noise, temperature stability, pixel uniformity and pixel yield. Additional mechanical constraints such as co-registration between the three arrays, filter design and assembly and testing will also be discussed. Published by Elsevier B.V. C1 [Jhabvala, M.; Reuter, D.; Jhabvala, C.] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. [Choi, K.] USA, Res Lab, Adelphi, MD 20783 USA. [Sundaram, M.] QmagiQ LLC, Nashua, NH 03063 USA. RP Jhabvala, M (reprint author), NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. EM murzy.d.jhabvala@nasa.gov NR 5 TC 19 Z9 20 U1 0 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1350-4495 J9 INFRARED PHYS TECHN JI Infrared Phys. Technol. PD NOV PY 2009 VL 52 IS 6 BP 424 EP 429 DI 10.1016/j.infrared.2009.05.027 PG 6 WC Instruments & Instrumentation; Optics; Physics, Applied SC Instruments & Instrumentation; Optics; Physics GA 539GB UT WOS:000273240700042 ER PT J AU Zheng, ZC Xu, Y Wilson, DK AF Zheng, Z. C. Xu, Ying Wilson, D. K. TI Behaviors of Vortex Wake in Random Atmospheric Turbulence SO JOURNAL OF AIRCRAFT LA English DT Article ID MODEL; AIRCRAFT; SIMULATIONS; DECAY; VORTICES; SHEAR AB Atmospheric turbulence was Significant influences oil both the trajectories and strengths of wake vortices. In this paper, a quasi-wavelet method is used to generate a random atmospheric turbulence field based on the von Karman spectrum, in which atmospheric turbulence is represented by groups of random eddies. An inviscid wake vortex system, out-of-ground effect or in-ground effect, is immersed in the generated turbulence background to study the effects of random turbulent e on wake vortices. The simulated wake trajectories are compared with literature data from several current prediction models as well as from field measurement. C1 [Zheng, Z. C.; Xu, Ying] Kansas State Univ, Dept Mech & Nucl Engn, Manhattan, KS 66506 USA. [Wilson, D. K.] USA, Signature Phys Branch, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Zheng, ZC (reprint author), Kansas State Univ, Dept Mech & Nucl Engn, Manhattan, KS 66506 USA. RI Zheng, Z/E-8930-2011; Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 NR 29 TC 0 Z9 2 U1 0 U2 2 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0021-8669 J9 J AIRCRAFT JI J. Aircr. PD NOV-DEC PY 2009 VL 46 IS 6 BP 2139 EP 2144 DI 10.2514/1.44288 PG 6 WC Engineering, Aerospace SC Engineering GA 532CS UT WOS:000272722300030 ER PT J AU Lopatnikov, SL Gama, BA Bogetti, TA Gillespie, JW AF Lopatnikov, Sergey L. Gama, Bazle A. Bogetti, Travis A. Gillespie, John W., Jr. TI Dynamics of a rigid plate impacting a glass plate: A one dimensional analysis considering failure-wave propagation SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID BRITTLE SOLIDS; COMPRESSION; VELOCITY AB Dynamics of a rigid plate impacting a glass plate is presented considering failure-wave and shock-wave propagations in the target material in addition to an elastic precursor. A generalized one dimensional theoretical failure-shock-elastic (FSE) model is developed and later simplified to study different impact scenarios on glass. While the nonlinear equations of the FSE model is solved numerically, an analytical solution is obtained for the failure-elastic submodel. In solving the failure-shock model for glass, a condition describing the jump in particle velocities at the failure front is proposed based on experimental observations. Time histories of the displacement, velocity, and resistance force of the rigid impact plate are presented. (C) 2009 American Institute of Physics. [doi: 10.1063/1.3245284] C1 [Lopatnikov, Sergey L.; Gama, Bazle A.; Gillespie, John W., Jr.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. [Bogetti, Travis A.] USA, Res Lab, Aberdeen Proving Ground, MD 21001 USA. [Gillespie, John W., Jr.] Univ Delaware, Dept Mat Sci & Engn, Newark, DE 19716 USA. [Gillespie, John W., Jr.] Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. RP Gama, BA (reprint author), Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. EM gama@udel.edu FU Army Research Laboratory [W911NF-06-2-011] FX Research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement No. W911NF-06-2-011. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation heron. NR 26 TC 1 Z9 1 U1 0 U2 14 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD NOV 1 PY 2009 VL 106 IS 9 AR 093521 DI 10.1063/1.3245284 PG 10 WC Physics, Applied SC Physics GA 529YP UT WOS:000272555700037 ER PT J AU Ely, BR Ely, MR Cheuvront, SN Kenefick, RW DeGroot, DW Montain, SJ AF Ely, Brett R. Ely, Matthew R. Cheuvront, Samuel N. Kenefick, Robert W. DeGroot, David W. Montain, Scott J. TI Evidence against a 40 degrees C core temperature threshold for fatigue in humans SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE ambient temperature; pacing; performance; body temperature ID PROLONGED EXERCISE; HEAT-STRESS; THERMOREGULATORY RESPONSES; ANTICIPATORY REGULATION; INDUCED HYPERTHERMIA; END-SPURT; BODY; ENVIRONMENT; EXHAUSTION; CHALLENGES AB Ely BR, Ely MR, Cheuvront SN, Kenefick RW, DeGroot DW, Montain SJ. Evidence against a 40 degrees C core temperature threshold for fatigue in humans. J Appl Physiol 107: 1519-1525, 2009. First published August 27, 2009; doi: 10.1152/japplphysiol.00577.2009.-Evidence suggests that core temperatures of similar to 40 degrees C can induce fatigue, although this may be confounded by coincident elevations in skin temperatures and maximal cardiovascular strain. In an observational field study to examine core temperature threshold for fatigue, we investigated whether running performance is impaired when rectal temperature (T(re)) is >40 degrees C and skin temperature remains modest. Seventeen competitive runners (7/10 women/men: 8 km best 1,759 +/- 78/1,531 +/- 60 s) completed 8-km track time trials in cool (WBGT similar to 13 degrees C; n = 6), warm (WBGT similar to 27 degrees C; n = 4), or both (n = 7) conditions. T(re), chest skin temperature, and heart rate were logged continuously; elapsed time was recorded every 200 m. Running velocity for T(re) > 40 degrees C was compared with that for T(re) < 40 degrees C for each runner. Changes in running velocity over the last 600 m were compared between runners with T(re) > 40 degrees C and < 40 degrees C. Twelve runners achieved T(re) > 40.0 degrees C with >= 600 m remaining (range 600-3,400 m). Average running velocity for T(re) > 40 degrees C (282 +/- 27 m/min) was not different from that for T(re) > 40 degrees C (279 +/- 28 m/min; P = 0.82). There were no differences in running velocity during the final 600 m between runners with final T(re) > 40 degrees C or < 40 degrees C (P = 0.16). Chest skin temperature ranged from 30 to 34 degrees C, and heart rate was > 95% of age-predicted maximum. Our observation that runners were able to sustain running velocity despite T(re) > 40 degrees C is evidence against 40 degrees C representing a "critical" core temperature limit to performance. C1 [Ely, Brett R.; Cheuvront, Samuel N.; Kenefick, Robert W.; DeGroot, David W.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. [Ely, Matthew R.; Montain, Scott J.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. RP Ely, BR (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St, Natick, MA 01760 USA. EM brett.ely@us.army.mil RI DeGroot, David/E-2322-2015 NR 45 TC 59 Z9 59 U1 3 U2 16 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD NOV PY 2009 VL 107 IS 5 BP 1519 EP 1525 DI 10.1152/japplphysiol.00577.2009 PG 7 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 515KO UT WOS:000271468900021 PM 19713430 ER PT J AU Patel, AA Torres, DM Harrison, SA AF Patel, Anish A. Torres, Dawn M. Harrison, Stephen A. TI Effect of Weight Loss on Nonalcoholic Fatty Liver Disease SO JOURNAL OF CLINICAL GASTROENTEROLOGY LA English DT Review DE NAFLD; weight loss; diet; exercise ID GASTRIC BYPASS-SURGERY; METABOLIC RISK-FACTORS; HEPATIC STEATOSIS; LOW-CARBOHYDRATE; KETOGENIC DIET; OVERWEIGHT PATIENTS; PHYSICAL-ACTIVITY; CONTROLLED-TRIAL; OBESE-PATIENTS; LIFE-STYLE AB Nonalcoholic fatty liver disease (NAFLD) has become one of the most common causes of liver disease worldwide and has grown proportionately with the rise in obesity. The prevalence of NAFLD is now thought to be around 20% to 40% of the entire population in industrialized Western countries. Insulin resistance, a product of obesity, is central to the pathogenesis of NAFLD, and is improved with weight loss, making this modality the primary goal of therapy. A combination of dietary modifications an increased physical activity, although hard to maintain, is thought to have significant long-term benefits, although further study is required to determine the best and most effective approaches to lifestyle modification. Alternatively, for those individuals who are unable to lose weight despite aggressive efforts. bariatric surgery, which has been shown rather convincingly to improve underlying fatty liver disease, may offer a solution. This review discusses dietary modification, exercise, weight loss pharmacotherapy, and Surgical intervention as potential options for patients with NAFLD. C1 [Patel, Anish A.; Torres, Dawn M.; Harrison, Stephen A.] Brooke Army Med Ctr, Dept Gastroenterol, Ft Sam Houston, TX 78234 USA. RP Harrison, SA (reprint author), Brooke Army Med Ctr, Dept Gastroenterol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Stephen.harrison@amedd.army.mil NR 46 TC 23 Z9 24 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0192-0790 J9 J CLIN GASTROENTEROL JI J. Clin. Gastroenterol. PD NOV-DEC PY 2009 VL 43 IS 10 BP 970 EP 974 PG 5 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 513FF UT WOS:000271307200015 PM 19727004 ER PT J AU Nelson, A Torres, DM Morgan, AE Fincke, C Harrison, SA AF Nelson, Austin Torres, Dawn M. Morgan, Ana E. Fincke, Christopher Harrison, Stephen A. TI A Pilot Study Using Simvastatin in the Treatment of Nonalcoholic Steatohepatitis A Randomized Placebo-controlled Trial SO JOURNAL OF CLINICAL GASTROENTEROLOGY LA English DT Article DE nonalcoholic steatohepatitis; statin; nonalcoholic fatty liver disease; HMG-CoA reductase inhibitors; randomized controlled trial ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; SERUM LEPTIN; ATORVASTATIN TREATMENT; METABOLIC SYNDROME; HEPATIC STEATOSIS; OBESE-PATIENTS; VITAMIN-E; ADIPONECTIN; NASH AB Goals: This Study was designed to assess the utility of statin therapy in patients with biopsy proven nonalcoholic steatohepatilis (NASH) and hvperlipidemia. Background: Nonalcoholic fatty liver disease, as the hepatic manifestation of the metabolic syndrome, has become a growing public health concern. Nonalcoholic steatohepatitis (NASH) represents a subset of nonalcoholic fatty liver disease manifested by hepatic fatty infiltration and inflammation which may progress to cirrhosis and its Subsequent complication, to include hepatocellular carcinoma. As the metabolic syndrome is thought to be central in the pathogenesis of NASH, it has been speculated that medications that improve metabolic profiles may be beneficial in treatment. In fact, recent studies have demonstrated potential benefit of 3-hydroxy-3-methyglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins), which Lire used in clinical practice to improve lipid panels. Study: This double-blinded randomized placebo-con trolled trial compared the HMG-CoA reductase inhibitor, simvastatin, with placebo in the treatment of NASH over a 12-month period using serum aminotransferases and repeat liver biopsy to assess for improvement. Results: Sixteen patients with biopsy proven NASH were enrolled: 14 completed the study and 10 underwent I-year repeat liver biopsy. Mean age: 53 years (+/- 10.1), mean body mass index: 32.4 (+/- 6.1) with 11 male and 5 female patients. Although a 26% reduction in low-density lipoprotein was seen in the simvastatin group compared with placebo, there was no statistically significant improvement ill Serum aminotransferases, hepatic steatosis necroinflammatory activity or stage of fibrosis within or between groups. Conclusions: In this pilot trial. monotherapy with simvastatin does not seem to be an effective treatment for NASH. C1 [Harrison, Stephen A.] Brooke Army Med Ctr, Dept Gastroenterol, Div Gastroenterol, Ft Sam Houston, TX 78234 USA. [Morgan, Ana E.] Brooke Army Med Ctr, Dept Internal Med, Ft Sam Houston, TX 78234 USA. [Nelson, Austin] Wilford Hall USAF Med Ctr, Dept Internal Med, Lackland AFB, TX 78236 USA. RP Harrison, SA (reprint author), Brooke Army Med Ctr, Dept Gastroenterol, Div Gastroenterol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM stephen.harrison@amedd.army.mil NR 39 TC 110 Z9 111 U1 0 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0192-0790 J9 J CLIN GASTROENTEROL JI J. Clin. Gastroenterol. PD NOV-DEC PY 2009 VL 43 IS 10 BP 990 EP 994 PG 5 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 513FF UT WOS:000271307200019 PM 19448566 ER PT J AU Das, NC AF Das, Naresh C. TI Performance Comparison of Top- and Bottom-emitting Long Wave Infrared Light Emitting Diode Devices SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE Light emitting diode (LED) device; surface emitting devices; infrared (IR) scene projection; long wave infrared (LWIR) emitters ID MU-M; QUANTUM-WELLS; LASERS AB Electroluminescence in the range of 5-10 mu m with peak emission at 8 mu m from an Sb-based type II interband quantum cascade structure is reported. We used both top- and flip-chip-mount bottom-emitting long wave infrared (LWIR) light emitting diode (LED) devices. An increase in light emission was observed by thinning the GaSb substrate material for both top- and bottom-emitting devices. For a similar GaSb substrate thickness, a flip-chip-mount bottom-emitting LED device had higher light emission intensity than a top-emitting device. Higher emission intensity for the bottom-emitting device was attributed to better cooling and to reflection of light from the anode metal surface in the LED mesa area. C1 USA, Microphoton Branch, Res Lab, Adelphi, MD 20783 USA. RP Das, NC (reprint author), USA, Microphoton Branch, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ndas@arl.army.mil NR 20 TC 3 Z9 3 U1 1 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD NOV PY 2009 VL 38 IS 11 BP 2329 EP 2334 DI 10.1007/s11664-009-0905-1 PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 504RL UT WOS:000270634800016 ER PT J AU Taylor, PJ Dhar, NK Harris, E Swaminathan, V Chen, Y Jesser, WA AF Taylor, P. J. Dhar, N. K. Harris, E. Swaminathan, V. Chen, Y. Jesser, W. A. TI Analysis of Dislocation Density in Pb((1-x))Sn (x) Se Grown on ZnTe/Si by MBE SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article ID MOLECULAR-BEAM EPITAXY; RELAXATION; SI(111); LAYERS; PBTE AB The growth of (211) Pb((1-x))Sn (x) Se on Si is achieved with a thick ZnTe buffer layer. The obtained films are specular, but contain widely dispersed void defects. Because the lattice misfit between Pb((1-x))Sn (x) Se and ZnTe is small, dislocation density values on the order of 10(6)/cm(2) in the Pb((1-x))Sn (x) Se are obtained. The variation of the dislocation density as a function of Pb((1-x))Sn (x) Se thickness, h, is analyzed in terms of dislocation annihilation. The analysis predicts an inverse quadratic dependence of dislocation density on h, and quantitative agreement with experimental measurements of the dislocation density is obtained. C1 [Taylor, P. J.; Dhar, N. K.; Harris, E.; Chen, Y.] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Swaminathan, V.] USA, Picatinny Arsenal, NJ 07806 USA. [Jesser, W. A.] Univ Virginia, Dept Mat Sci & Engn, Charlottesville, VA 22903 USA. RP Taylor, PJ (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM patrick.taylor7@us.army.mil NR 17 TC 5 Z9 5 U1 2 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD NOV PY 2009 VL 38 IS 11 BP 2343 EP 2347 DI 10.1007/s11664-009-0907-z PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 504RL UT WOS:000270634800018 ER PT J AU Douglas, TA Walsh, ME McGrath, CJ Weiss, CA AF Douglas, Thomas A. Walsh, Marianne E. McGrath, Christian J. Weiss, Charles A., Jr. TI Investigating the Fate of Nitroaromatic (TNT) and Nitramine (RDX and HMX) Explosives in Fractured and Pristine Soils SO JOURNAL OF ENVIRONMENTAL QUALITY LA English DT Article ID CLAY-MINERALS; WATER SLURRIES; ADSORPTION; SORPTION; 2,4,6-TRINITROTOLUENE; DESORPTION; DISSOLUTION; REDUCTION; TRANSPORT; FE(II) AB Explosives compounds, known toxins, are loaded to soils on military training ranges predominantly during explosives detonation events that likely fracture soil particles. This study was conducted to investigate the fate Of explosives Compounds in aqueous slurries containing fractured and pristine soil particles. Three soils were crushed with a piston to emulate detonation-induced fracturing. X-ray diffraction, energy-dispersive X-ray spectrometry, gas adsorption surface area measurements, and scanning electron microscopy were used to quantify and image pristine and fractured soil particles. Aqueous batches were prepare by spiking soils with solutions containing 2,4,6-trinitrotoluene (TNT), hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), octahydro 1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX), and 2,4-dinitrotoluene (2,4-DNT). Samples were collected over 92 d and the concentrations of the spiked explosives compounds and TNT transformation products 2-amino-4,6-dinitrotoluene (2ADNT) and 4-amino-2,6-dinitrotoluene (4ADNT) were measured. Our results suggest soil mineralogical and geochemical compositions were not changed during piston-induced fracturing but morphological differences were evident with fractured soils exhibiting more angular surfaces, more fine grained particles, and some microfracturing that is not visible in the pristine samples. TNT. 2,4-DNT, RDX, and HMX exhibited greater analyte loss over time in batch solutions containing fractured soil particles compared to their pristine counterparts. 2ADNT and 4ADNT exhibited greater concentrations in slurries containing pristine Soils than in slurries containing fractured soils. Explosives compound transformation is greater in the presence of fracture soil particles than in the presence of pristine soil particles. Our results imply fractured soil particles promote explosive compound transformation and/or explosives compounds have a greater affinity for adsorption to fractured soil particle surfaces. C1 [Douglas, Thomas A.] Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. [Walsh, Marianne E.] Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [McGrath, Christian J.] Environm Lab, Vicksburg, MS 39180 USA. [Weiss, Charles A., Jr.] Geotech & Struct Lab, Vicksburg, MS 39180 USA. RP Douglas, TA (reprint author), Cold Reg Res & Engn Lab, POB 35170, Ft Wainwright, AK 99703 USA. EM thomas.a.douglas@usace.army.mil NR 47 TC 4 Z9 4 U1 1 U2 6 PU AMER SOC AGRONOMY PI MADISON PA 677 S SEGOE RD, MADISON, WI 53711 USA SN 0047-2425 J9 J ENVIRON QUAL JI J. Environ. Qual. PD NOV-DEC PY 2009 VL 38 IS 6 BP 2285 EP 2294 DI 10.2134/jeq2008.0477 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA 519NU UT WOS:000271774400015 PM 19875785 ER PT J AU Parra, RR Medina, VF Conca, JL AF Parra, R. R. Medina, V. F. Conca, J. L. TI The use of fixatives for response to a radiation dispersal devise attack - a review of the current (2009) state-of-the-art SO JOURNAL OF ENVIRONMENTAL RADIOACTIVITY LA English DT Review DE Radioactive contaminant; Dirty bomb; Asphalt pitch emulsions; Environmental; Terrorism; Containment ID DIRTY BOMB; RADIOACTIVE-WASTE; EMULSIONS; SURFACE AB Radiation dispersal devices (RDDs), or dirty bombs, are terrorist weapons designed to scatter radioactive materials in large urban areas. Although the main intent of a RDD is to produce general panic and chaos, other impacts such as health, environmental, property and economical damage may also occur. Although one certain method of reducing health risks from a RDD event is to remove the radioactive contaminants from the environment immediately, rapid cleanup after a RDD event may be impossible in many cases. However, preventing the migration of the radioactive contaminant is crucial. Although it may be necessary to allow the contaminant to remain in place, preventing its migration is still essential. Fixatives can reduce or eliminating migration potential of a contaminant introduced by a RDD. This paper reviews the significance of fixatives in response to a RDD event and some of the products which have been identified for such a purpose. Many of the products are promising for application. However, many reports lack quantitative information to allow for effective comparative evaluation. Further, key parameters, such as shelf life and product toxicity, are not typically evaluated. We recommend that standardized performance parameters be established to allow for better comparative evaluation. (c) 2009 Elsevier Ltd. All rights reserved. C1 [Parra, R. R.] New Mexico State Univ, Phys Sci Lab, Las Cruces, NM 88003 USA. [Medina, V. F.] USA, Corps Engineers, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. [Conca, J. L.] New Mexico State Univ, Coll Engn, Carlsbad Environm Monitoring & Res Ctr, Carlsbad, NM 88220 USA. RP Parra, RR (reprint author), New Mexico State Univ, Phys Sci Lab, POB 30001,MSC PSL, Las Cruces, NM 88003 USA. EM rparra@psl.nmsu.edu NR 88 TC 8 Z9 8 U1 1 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0265-931X J9 J ENVIRON RADIOACTIV JI J. Environ. Radioact. PD NOV PY 2009 VL 100 IS 11 BP 923 EP 934 DI 10.1016/j.jenvrad.2009.07.006 PG 12 WC Environmental Sciences SC Environmental Sciences & Ecology GA 504OR UT WOS:000270627000001 PM 19700226 ER PT J AU Votypka, J Lantova, L Ghosh, K Braig, H Volf, P AF Votypka, Jan Lantova, Lucie Ghosh, Kashinath Braig, Henk Volf, Petr TI Molecular Characterization of Gregarines from Sand Flies (Diptera: Psychodidae) and Description of Psychodiella n. g. (Apicomplexa: Gregarinida) SO JOURNAL OF EUKARYOTIC MICROBIOLOGY LA English DT Article DE Accessory glands; Ascogregarina; Lutzomyia; neogregarines; parasite; Phlebotomus; SSU rDNA phylogeny ID ASCOGREGARINA-CHAGASI EUGREGARINORIDA; PHLEBOTOMUS-PAPATASI DIPTERA; MARINE GREGARINES; LUTZOMYIA-LONGIPALPIS; PHYLOGENETIC ANALYSIS; LECUDINIDAE; MORPHOLOGY; SEQUENCES; COCCIDIA; TREES AB Sand fly and mosquito gregarines have been lumped for a long time in the single genus Ascogregarina and on the basis of their morphological characters and the lack of merogony been placed into the eugregarine family Lecudinidae. Phylogenetic analyses performed in this study clearly demonstrated paraphyly of the current genus Ascogregarina and revealed disparate phylogenetic positions of gregarines parasitizing mosquitoes and gregarines retrieved from sand flies. Therefore, we reclassified the genus Ascogregarina and created a new genus Psychodiella to accommodate gregarines from sand flies. The genus Psychodiella is distinguished from all other related gregarine genera by the characteristic localization of oocysts in accessory glands of female hosts, distinctive nucleotide sequences of the small subunit rDNA, and host specificity to flies belonging to the subfamily Phlebotominae. The genus comprises three described species: the type species for the new genus-Psychodiella chagasi (Adler and Mayrink 1961) n. comb., Psychodiella mackiei (Shortt and Swaminath 1927) n. comb., and Psychodiella saraviae (Ostrovska, Warburg, and Montoya-Lerma 1990) n. comb. Its creation is additionally supported by sequencing data from other gregarine species originating from the sand fly Phlebotomus sergenti. In the evolutionary context, both genera of gregarines from mosquitoes (Ascogregarina) and sand flies (Psychodiella) have a close relationship to neogregarines; the genera represent clades distinct from the other previously sequenced gregarines. C1 [Votypka, Jan; Lantova, Lucie; Volf, Petr] Charles Univ Prague, Dept Parasitol, Fac Sci, CZ-12844 Prague 2, Czech Republic. [Votypka, Jan] Acad Sci Czech Republic, Ctr Biol, Inst Parasitol, CZ-37005 Ceske Budejovice, Czech Republic. [Ghosh, Kashinath] Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD 20910 USA. [Braig, Henk] Bangor Univ, Sch Biol Sci, Bangor LL57 2UW, Gwynedd, Wales. RP Volf, P (reprint author), Charles Univ Prague, Dept Parasitol, Fac Sci, Vinicna 7, CZ-12844 Prague 2, Czech Republic. EM volf@cesnet.cz RI Volf, Petr/C-4300-2012; Votypka, Jan/C-5313-2012; Braig, Henk/I-5477-2013 OI Volf, Petr/0000-0003-1790-1123; Votypka, Jan/0000-0002-0552-9363; Braig, Henk/0000-0001-9592-1141 FU Ministry of Education, Czech Republic [MSM0021620828, LC06009]; National Research Council, National Academy of Sciences, USA FX We thank David ModrY for stimulating discussions and helpful comments. J.V, L.L., and P.V. were supported by the Ministry of Education, Czech Republic (MSM0021620828, LC06009) and K.G. by National Research Council, National Academy of Sciences, USA. NR 47 TC 15 Z9 16 U1 0 U2 5 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1066-5234 J9 J EUKARYOT MICROBIOL JI J. Eukaryot. Microbiol. PD NOV-DEC PY 2009 VL 56 IS 6 BP 583 EP 588 DI 10.1111/j.1550-7408.2009.00438.x PG 6 WC Microbiology SC Microbiology GA 511SV UT WOS:000271188700010 PM 19883447 ER PT J AU deWeber, K Beutler, A AF deWeber, Kevin Beutler, Anthony TI Hypertrophic cardiomyopathy: Ask athletes these 9 questions SO JOURNAL OF FAMILY PRACTICE LA English DT Article C1 [deWeber, Kevin] Uniformed Serv Univ Hlth Sci, Dept Family Med, USA, Bethesda, MD USA. [Beutler, Anthony] Uniformed Serv Univ Hlth Sci, Dept Family Med, USAF, Bethesda, MD USA. RP deWeber, K (reprint author), Uniformed Serv Univ Hlth Sci, Dept Family Med, USA, Bethesda, MD USA. EM abeutler@usuhs.mil NR 39 TC 4 Z9 4 U1 0 U2 1 PU DOWDEN HEALTH MEDIA PI MONTVALE PA 110 SUMMIT AVE, MONTVALE, NJ 07645-1712 USA SN 0094-3509 J9 J FAM PRACTICE JI J. Fam. Pract. PD NOV PY 2009 VL 58 IS 11 BP 576 EP 584 PG 9 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA V18IT UT WOS:000207999200003 PM 19891935 ER PT J AU Adams, N Perlin, V Rohde, M Gaffney, R Harmsen, N Kriigel, C AF Adams, Norman Perlin, Victor Rohde, Mitchell Gaffney, Robert Harmsen, Natalia Kriigel, Carl TI Upper-Bounding the Incidence Rate of Associations Between Camouflage Uniforms and Surveillance Images SO JOURNAL OF FORENSIC SCIENCES LA English DT Article DE forensic science; individualization; statistical modeling; incidence rate; camouflage garments; surveillance images ID FINGERPRINT IDENTIFICATION; SCIENCE AB Camouflage garments can be associated with surveillance images of a crime scene even in the absence of unique wear marks or very high-quality images. However, the probability of an accidental association, or incidence rate, is significant. The present work describes and validates a method for estimating the incidence rate based on a statistical model of the garment manufacturing process. The model was developed primarily for use with the current U. S. Army Combat Uniform (ACU), but can be applied to any camouflage garment. Eight garment manufacturers were studied, and all sources of variation in the manufacturing process were characterized. The marking and spreading procedures were found to be dominant and consistent sources of variation. However, some sources of variation, in particular those because of human operators, were not consistent enough to accurately characterize. Sources of variation that could not be well-characterized were ignored in the statistical model, yielding a worst-case estimate that is an upper-bound to the true incidence rate. The model was evaluated for a variety of cases. Depending on the quality of the surveillance image, the manufacturing parameters, and the local population, incidence rates range from about 3% to negligibly small. The model was validated by returning to one manufacturer, and sampling a large number of completed garments and estimating empirical match probabilities. The empirical probabilities validated the estimates of the worst-case incidence rate and also demonstrated that typical incidence rates are significantly lower. C1 [Adams, Norman; Perlin, Victor; Rohde, Mitchell] Quantum Signal LLC, Ann Arbor, MI 48108 USA. [Gaffney, Robert; Harmsen, Natalia; Kriigel, Carl] USA, Criminal Invest Lab, Forest Pk, GA 30297 USA. RP Rohde, M (reprint author), Quantum Signal LLC, 3741 Plaza Dr,Suite 1, Ann Arbor, MI 48108 USA. EM rohde@quantumsignal.com FU Technical Support Working Group (TSWG) FX This project was supported by the Technical Support Working Group (TSWG). NR 18 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD NOV PY 2009 VL 54 IS 6 BP 1393 EP 1406 DI 10.1111/j.1556-4029.2009.01151.x PG 14 WC Medicine, Legal SC Legal Medicine GA 509ZS UT WOS:000271058400027 PM 19737341 ER PT J AU Tamm, G Boettner, DD Van Poppel, BP Benson, MJ Arnas, AO AF Tamm, Gunnar Boettner, Daisie D. Van Poppel, Bret P. Benson, Michael J. Arnas, A. Oezer TI On the Similarity Solution for Condensation Heat Transfer SO JOURNAL OF HEAT TRANSFER-TRANSACTIONS OF THE ASME LA English DT Article; Proceedings Paper CT ASME International Mechanical Engineering Congress CY NOV 13-19, 2004 CL Anaheim, CA SP ASME DE film condensation; similarity solution; vertical plate ID SURFACE CONDENSATION; FUNDAMENTALS AB Analytical solutions for laminar film condensation on a vertical plate are integral to many heat transfer applications, and have therefore been presented in numerous refereed articles and in most heat transfer textbooks. Commonly made assumptions achieve the well known similarity solution for the Nusselt number heat transfer coefficient, and film thickness. Yet in all of these studies, several critical assumptions are made without just tifying their use. Consequently, for a given problem one cannot determine whether these restrictive assumptions are actually satisfied, and thus, how these conditions can be checked for-validity of the results. This study provides a detailed solution that clarifies these points. [DOI: 10.1115/1.3154920] C1 [Tamm, Gunnar; Boettner, Daisie D.; Van Poppel, Bret P.; Benson, Michael J.; Arnas, A. Oezer] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. RP Tamm, G (reprint author), US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. EM gunnar.tamm@usma.edu NR 38 TC 1 Z9 1 U1 0 U2 2 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0022-1481 J9 J HEAT TRANS-T ASME JI J. Heat Transf.-Trans. ASME PD NOV PY 2009 VL 131 IS 11 AR 111501 DI 10.1115/1.3154920 PG 5 WC Thermodynamics; Engineering, Mechanical SC Thermodynamics; Engineering GA 501ST UT WOS:000270403200009 ER PT J AU Clifton, GT Ciano, K Zacharia, A Mutsal, M Jama, Y Ishizaka, S Hawkins, L Peoples, GE Ponniah, S AF Clifton, Guy T. Ciano, Kathy Zacharia, Athina Mutsal, Mohmed Jama, Yusuf Ishizaka, Sally Hawkins, Lynn Peoples, George E. Ponniah, Sathibalan TI E6020, a Novel Immunoadjuvant, is Effective at Stimulating HER2/NEU Cancer Immunity in Healthy Donors and Breast Cancer Patients SO JOURNAL OF IMMUNOTHERAPY LA English DT Meeting Abstract CT 24th Annual Meeting of the International-Society-for-Biology-Therapy-of-Cancer CY OCT 29-31, 2009 CL Washington, DC SP Int Soc Biol Therapy Canc C1 [Clifton, Guy T.; Peoples, George E.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Ciano, Kathy; Zacharia, Athina; Mutsal, Mohmed; Jama, Yusuf; Ponniah, Sathibalan] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Ishizaka, Sally; Hawkins, Lynn] Eisai Res Inst, Andover, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1524-9557 J9 J IMMUNOTHER JI J. Immunother. PD NOV-DEC PY 2009 VL 32 IS 9 BP 968 EP 968 PG 1 WC Oncology; Immunology; Medicine, Research & Experimental SC Oncology; Immunology; Research & Experimental Medicine GA 510RX UT WOS:000271110100089 ER PT J AU Wierkowski, EU Lee, JJ Mailliard, R Muthuswamy, R Chatta, G Zeh, H Foon, K Maxwell, GL Herberman, R Edwards, R Bartlett, D Kalinski, P AF Wierkowski, Eva U. Lee, Je-Jung Mailliard, Robbie Muthuswamy, Ravikumar Chatta, Gurkamal Zeh, Herbert Foon, Kenneth Maxwell, George L. Herberman, Ron Edwards, Robert Bartlett, David Kalinski, Pawel TI Type-1-polarized Dendritic Cells (alpha DC1) Loaded With Autologous or Allogeneic Tumor Material are Effective Inducers of Tumor-specific Cytotoxic T Lymphocytes Against CLL, Prostate, Colorectal, Ovarian, and Endometrial Cancer SO JOURNAL OF IMMUNOTHERAPY LA English DT Meeting Abstract CT 24th Annual Meeting of the International-Society-for-Biology-Therapy-of-Cancer CY OCT 29-31, 2009 CL Washington, DC SP Int Soc Biol Therapy Canc C1 [Wierkowski, Eva U.; Lee, Je-Jung] Univ Pittsburgh, Dept Surg, Pittsburgh, PA USA. Univ Pittsburgh, Dept Med, Pittsburgh, PA USA. Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA. Walter Reed Army Med Ctr, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1524-9557 J9 J IMMUNOTHER JI J. Immunother. PD NOV-DEC PY 2009 VL 32 IS 9 BP 1010 EP 1010 PG 1 WC Oncology; Immunology; Medicine, Research & Experimental SC Oncology; Immunology; Research & Experimental Medicine GA 510RX UT WOS:000271110100218 ER PT J AU Culleton, R Ndounga, M Zeyrek, FY Coban, C Casimiro, PN Takeo, S Tsuboi, T Yadava, A Carter, R Tanabe, K AF Culleton, Richard Ndounga, Mathieu Zeyrek, Fadile Yildiz Coban, Cevayir Casimiro, Prisca Nadine Takeo, Satoru Tsuboi, Takafumi Yadava, Anjali Carter, Richard Tanabe, Kazuyuki TI Evidence for the Transmission of Plasmodium vivax in the Republic of the Congo, West Central Africa SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID NEGATIVE INDIVIDUALS; LIVER-STAGE; ANTIGEN; SPOROZOITES AB Plasmodium vivax is not thought to be transmitted in western and central Africa, because of the very high prevalence of the red blood cell Duffy-negative phenotype in local populations, a condition which is thought to confer complete resistance against blood infection with P. vivax. There are, however, persistent reports of travelers returning from this region with P. vivax infections. To investigate whether transmission occurs in this region, the presence of antibodies specific to P. vivax preerythrocytic-stage antigens was assessed in individuals from the Republic of the Congo. A total of 55 (13%) of 409 samples tested by enzyme-linked immunosorbent assay had antibodies to P. vivax-specific antigens. C1 [Culleton, Richard] Nagasaki Univ, Dept Protozool, Inst Trop Med NEKKEN, Nagasaki 8528523, Japan. [Culleton, Richard] Nagasaki Univ, Global Centers Excellence Program, Nagasaki 8528523, Japan. [Culleton, Richard; Tanabe, Kazuyuki] Osaka Univ, Int Res Ctr Infect Dis, Microbial Dis Res Inst, Lab Malariol, Osaka, Japan. [Coban, Cevayir] Osaka Univ, Host Def Lab, World Premier Int Immunol Frontier Res Ctr, Osaka, Japan. [Takeo, Satoru; Tsuboi, Takafumi] Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime 790, Japan. [Ndounga, Mathieu; Casimiro, Prisca Nadine] Ctr Etud Resources Vegetales, Brazzaville, Congo. [Zeyrek, Fadile Yildiz] Harran Univ, Fac Med, Dept Microbiol, Sanliurfa, Turkey. [Carter, Richard] Univ Edinburgh, Inst Immunol & Infect Res, Edinburgh, Midlothian, Scotland. [Yadava, Anjali] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. RP Carter, R (reprint author), Nagasaki Univ, Dept Protozool, Inst Trop Med, 1-12-4 Sakamoto, Nagasaki 8528523, Japan. EM richard@nagasaki-u.ac.jp; kztanabe@biken.osaka-u.ac.jp RI Coban, Cevayir/B-2129-2012; OI Culleton, Richard/0000-0001-8808-5771 NR 13 TC 38 Z9 39 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 1 PY 2009 VL 200 IS 9 BP 1465 EP 1469 DI 10.1086/644510 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 504XY UT WOS:000270652800015 PM 19803728 ER PT J AU Sanghadasa, M Ashley, PR Guenthner, AJ Lindsay, GA Bramson, MD AF Sanghadasa, Mohan Ashley, Paul R. Guenthner, Andrew J. Lindsay, Geoffrey A. Bramson, Michael D. TI Design and Demonstration of Polarizing Polymer Waveguides Using Birefringent Polymers SO JOURNAL OF LIGHTWAVE TECHNOLOGY LA English DT Article DE Birefringence; electro-optic polymers; polarization; polymer waveguides ID TM MODE SPLITTER; POLYIMIDE FILMS; POLARIZATION SPLITTER; ELECTROOPTIC POLYMERS; OPTICAL ANISOTROPY; THIN-FILMS; FABRICATION; COMPONENTS; INDEX AB TE-pass and TM-pass polarizing waveguides were fabricated by adjusting the birefringence properties of multi-layer stacks. The desired values of indices of refraction and birefringence were obtained by the proper selection and customization of core and cladding materials. The technique developed was used in the fabrication of waveguides in various design configurations such as etched ribs, backfilled trenches and photobleached channels. Both passive and active (electro-optic) core materials were successfully used in demonstrating the polarization extinction ratios as high as 61 dB. To our knowledge, this is the highest extinction ratio reported with polarizing polymer waveguides. In the case of electro-optic polymer waveguides, the designs were modified to enhance the electric field strength in the core without compromising the polarizing extinction ratios of the waveguides. C1 [Sanghadasa, Mohan; Ashley, Paul R.] US Army Res Dev & Engn Command, Weap Sci Directorate, Redstone Arsenal, AL 35898 USA. [Guenthner, Andrew J.; Lindsay, Geoffrey A.; Bramson, Michael D.] NAVAIR, Res Dept, China Lake, CA 93555 USA. RP Sanghadasa, M (reprint author), US Army Res Dev & Engn Command, Weap Sci Directorate, Redstone Arsenal, AL 35898 USA. EM Mohan.Sanghadasa@us.army.mil; Paul.Ashley@us.army.mil; Andrew.Guenthner@navy.mil; Geoffrey.Lindsay@navy.mil; Michael.Bramson@navy.mil FU Office of Naval Research FX The authors would like to thank the Office of Naval Research for providing project support. NR 41 TC 1 Z9 1 U1 3 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0733-8724 J9 J LIGHTWAVE TECHNOL JI J. Lightwave Technol. PD NOV 1 PY 2009 VL 27 IS 21 BP 4667 EP 4677 DI 10.1109/JLT.2009.2025393 PG 11 WC Engineering, Electrical & Electronic; Optics; Telecommunications SC Engineering; Optics; Telecommunications GA 493XS UT WOS:000269773400001 ER PT J AU Grujicic, M Pandurangan, B Bell, WC Coutris, N Cheeseman, BA Fountzoulas, C Patel, P Templeton, DW Bishnoi, KD AF Grujicic, M. Pandurangan, B. Bell, W. C. Coutris, N. Cheeseman, B. A. Fountzoulas, C. Patel, P. Templeton, D. W. Bishnoi, K. D. TI An Improved Mechanical Material Model for Ballistic Soda-Lime Glass SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE ballistic performance; electron microscopy; failure analysis; glass; material modeling ID BRITTLE MATERIALS; FRAGMENTATION; FRACTURE; DAMAGE; DEFORMATION AB In our recent work (Grujicic et al., Int. J. Impact Eng., 2008), various open-literature experimental findings pertaining to the ballistic behavior of soda-lime glass were used to construct a simple, physically based, high strain rate, high-pressure, large-strain mechanical model for this material. The model was structured in such a way that it is suitable for direct incorporation into standard commercial transient non-linear dynamics finite element-based software packages like ANSYS/Autodyn (Century Dynamics Inc., 2007) or ABAQUS/Explicit (Dessault Systems, 2007). To validate the material model, a set of finite element analyses of the edge-on-impact tests was conducted and the results compared with their experimental counterparts obtained in the recent work of Strassburger et al. (Proceedings of the 23rd International Symposium on Ballistics, Spain, April 2007; Proceedings of the 22nd International Symposium on Ballistics, November 2005, Vancouver, Canada). In general, a good agreement was found between the computational and the experimental results relative to: (a) the front shapes and the propagation velocities of the longitudinal and transverse waves generated in the target during impact and (b) the front shapes and propagation velocities of a coherent-damage zone (a zone surrounding the projectile/target contact surface which contains numerous micron and submicron-size cracks). However, substantial computational analysis/experiment disagreements were found relative to the formation of crack centers, i.e. relative to the presence and distribution of isolated millimeter-size cracks nucleated ahead of the advancing coherent-damage zone front. In the present work, it was shown that these disagreements can be substantially reduced if the glass model (Grujicic et al., Int. J. Impact Eng., 2008) is advanced to include a simple macrocracking algorithm based on the linear elastic fracture mechanics. C1 [Grujicic, M.; Pandurangan, B.; Bell, W. C.; Coutris, N.] Clemson Univ, Int Ctr Automot Res CU ICAR, Dept Mech Engn, Clemson, SC 29634 USA. [Cheeseman, B. A.; Fountzoulas, C.; Patel, P.] USA, Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA. [Templeton, D. W.; Bishnoi, K. D.] USA, TARDEC, Warren, MI 48397 USA. RP Grujicic, M (reprint author), Clemson Univ, Int Ctr Automot Res CU ICAR, Dept Mech Engn, Clemson, SC 29634 USA. EM mica.grujicic@ces.clemson.edu FU U.S. Army/Clemson University [W911NF-04-2-0024, W911NF-06-2-0042]; ARC-TARDEC FX The material presented in this article is based on work supported by the U.S. Army/Clemson University Cooperative Agreements W911NF-04-2-0024 and W911NF-06-2-0042 and by an ARC-TARDEC research contract. NR 24 TC 22 Z9 22 U1 2 U2 16 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD NOV PY 2009 VL 18 IS 8 BP 1012 EP 1028 DI 10.1007/s11665-008-9343-0 PG 17 WC Materials Science, Multidisciplinary SC Materials Science GA 509OK UT WOS:000271027100003 ER PT J AU Phasomkusolsil, S Tanskul, P Ratanatham, S Watcharapichat, P Phulsuksombati, D Frances, SP Lerdthusnee, K Linthicum, KJ AF Phasomkusolsil, Siriporn Tanskul, Panita Ratanatham, Supaporn Watcharapichat, Pochaman Phulsuksombati, Duangporn Frances, Stephen P. Lerdthusnee, Kriangkrai Linthicum, Kenneth J. TI Transstadial and Transovarial Transmission of Orientia tsutsugamushi in Leptotrombidium imphalum and Leptotrombidium chiangraiensis (Acari: Trombiculidae) SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Orientia tsutsugamushi; transmission; Leptotrombidium imphalum; Leptotrombidium chiangraiensis; chiggers ID RICKETTSIA-TSUTSUGAMUSHI; VERTICAL TRANSMISSION; CHIGGERS; PALLIDUM; MITES AB Transovarial transmission of Orientia tsutsugamushi (Hayashi) in laboratory colonies of Leptotrombidium chiangraiensis Tanskul & Linthicum and Leptotrombidium imphalum (Vercammen-Grandjean & Langston) (Acari: Trombiculidae) was studied for two generations. In L. chiangraiensis, the transovarial and filial infection rate was 100% in each generation. Only infected females were produced. In L. imphalum, the transovarial infection rate of the parental generation was 100% but declined to 93.3% in the F(1) generation. The overall filial infection rate was 100% in the F(1) but was only 62.3% in the F(2) generation. In infected lines, only infected females were produced in the F(1) generation, but 1.5% of the F(2) progeny were infected males. Lower rates of transovarial transmission in L. imphalum may be the cause of the lower natural infection rates found in nature. C1 [Phasomkusolsil, Siriporn; Tanskul, Panita; Frances, Stephen P.; Lerdthusnee, Kriangkrai; Linthicum, Kenneth J.] Armed Forces Res Inst Med Sci, US Army Med Component, Dept Entomol, Bangkok 10400, Thailand. [Ratanatham, Supaporn] Mahidol Univ, Dept Environm Biol, Bangkok 10400, Thailand. [Watcharapichat, Pochaman; Phulsuksombati, Duangporn] Armed Forces Res Inst Med Sci, Dept Vet Med, Bangkok 10400, Thailand. RP Frances, SP (reprint author), Australian Army Malaria Inst, Enoggera, Qld 4051, Australia. FU U.S. Army Medical and Material Command FX We thank Inkam Inlao, Taweesak Monkhanna and Nittaya Khlaimanee, Department of Entomology, AFRIMS, Bangkok, Thailand, for assistance in the field and laboratory. Funding for this project was partially provided by the U.S. Army Medical and Material Command. NR 21 TC 12 Z9 12 U1 0 U2 2 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD NOV PY 2009 VL 46 IS 6 BP 1442 EP 1445 DI 10.1603/033.046.0628 PG 4 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 517CW UT WOS:000271591800028 PM 19960694 ER PT J AU Hartings, JA Strong, AJ Fabricius, M Manning, A Bhatia, R Dreier, JP Mazzeo, AT Tortella, FC Bullock, MR AF Hartings, Jed A. Strong, Anthony J. Fabricius, Martin Manning, Andrew Bhatia, Robin Dreier, Jens P. Mazzeo, Anna Teresa Tortella, Frank C. Bullock, M. Ross CA CoOperative Study Brain Injury Dep TI Spreading Depolarizations and Late Secondary Insults after Traumatic Brain Injury SO JOURNAL OF NEUROTRAUMA LA English DT Article DE electroencephalography; hyperthermia; intracranial hypertension; spreading cortical depression; vascular hypotension ID FOCAL CEREBRAL-ISCHEMIA; SEVERE HEAD-INJURY; PERIINFARCT DEPOLARIZATIONS; BLOOD-FLOW; INTENSIVE-CARE; DEPRESSION; SEIZURES; PRESSURE; RISK; MECHANISMS AB Here we investigated the incidence of cortical spreading depolarizations (spreading depression and peri-infarct depolarization) after traumatic brain injury (TBI) and their relationship to systemic physiologic values during neurointensive care. Subdural electrode strips were placed on peri-contusional cortex in 32 patients who underwent surgical treatment for TBI. Prospective electrocorticography was performed during neurointensive care with retrospective analysis of hourly nursing chart data. Recordings were 84 hr (median) per patient and 2,503 hr in total. In 17 patients (53%), 280 spreading depolarizations (spreading depressions and peri-infarct depolarizations) were observed. Depolarizations occurred in a bimodal pattern with peak incidence on days 1 and 7. The probability of a depolarization occurring increased significantly as a function of declining mean arterial pressure (MAP; R-2 = 0.78; p < 0.001) and cerebral perfusion pressure (R-2 = 0.85; p < 0.01), and increasing core temperature (R-2 = 0.44; p < 0.05). Depolarization probability was 7% for MAP values of > 100 mm Hg but 33% for MAP of <= 70 mm Hg. Temperatures of <= 38.4 degrees C were associated with a 21% depolarization risk, compared to 63% for > 38.4 degrees C. Intracranial pressures were higher in patients with depolarizations (18.3 +/- 9.3 vs. 13.5 +/- 6.7 mm Hg; p < 0.001). We conclude that depolarization phenomena are a common cortical pathology in TBI. Their association with lower perfusion levels and higher temperatures suggests that the labile balance of energy supply and demand is an important determinant of their occurrence. Monitoring of depolarizations might serve as a functional measure to guide therapeutic efforts and their blockade may provide an additional line of defense against the effects of secondary insults. C1 [Hartings, Jed A.] Univ Cincinnati, Dept Neurosurg, Inst Neurosci, Cincinnati, OH 45219 USA. [Strong, Anthony J.; Manning, Andrew; Bhatia, Robin] Kings Coll Hosp London, Dept Neurosurg, London, England. [Fabricius, Martin] Glostrup Cty Hosp, Dept Clin Neurophysiol, Copenhagen, Denmark. [Dreier, Jens P.] Charite, Ctr Stroke Res Berlin, D-13353 Berlin, Germany. [Mazzeo, Anna Teresa; Bullock, M. Ross] Virginia Commonwealth Univ, Div Neurosurg, Richmond, VA USA. [Mazzeo, Anna Teresa] Univ Messina, Dept Neurosci Psychiat & Anesthesiol Sci, Messina, Italy. [Tortella, Frank C.] Walter Reed Army Inst Res, Dept Appl Neurobiol, Silver Spring, MD USA. RP Hartings, JA (reprint author), Univ Cincinnati, Dept Neurosurg, Inst Neurosci, 260 Stetson St,Suite 2200, Cincinnati, OH 45219 USA. EM jed.hartings@uc.edu OI Mazzeo, Anna Teresa/0000-0002-8454-7243; Dreier, Jens/0000-0001-7459-2828 FU NINDS [PO1 NS12587-27]; German Research Foundation (DFG) [SFB Tr3 D10, DR 323/3-1]; Novo Nordisk Foundation FX We thank Charlotte Gilman, Marinella Gugliotta, and Amedeo Merenda for their valuable contributions. This work was supported in part by NINDS PO1 NS12587-27 (to R. B.), the German Research Foundation (DFG) SFB Tr3 D10 and DR 323/3-1 (to J. D.), and the Novo Nordisk Foundation (to M. F.). NR 41 TC 60 Z9 61 U1 0 U2 4 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD NOV PY 2009 VL 26 IS 11 BP 1857 EP 1866 DI 10.1089/neu.2009.0961 PG 10 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 523CO UT WOS:000272049600001 PM 19508156 ER PT J AU Chen, ZY Tortella, FC Dave, JR Marshall, VS Clarke, DL Sing, G Du, F Lu, XCM AF Chen, Zhiyong Tortella, Frank C. Dave, Jitendra R. Marshall, Vivienne S. Clarke, Diana L. Sing, George Du, Fu Lu, X. -C. May TI Human Amnion-Derived Multipotent Progenitor Cell Treatment Alleviates Traumatic Brain Injury-Induced Axonal Degeneration SO JOURNAL OF NEUROTRAUMA LA English DT Article DE axon degeneration; human amnion; penetrating ballistic-like brain injury; progenitor cells; traumatic brain injury ID CENTRAL-NERVOUS-SYSTEM; MARROW STROMAL CELLS; EMBRYONIC STEM-CELLS; EPITHELIAL-CELLS; RAT MODEL; PRECURSOR CELLS; SPINAL-CORD; TRANSPLANTATION; NEURONS; NEUROGENESIS AB To identify a viable cell source with potential neuroprotective effects, we studied amnion-derived multipotent progenitor (AMP) cells in a rat model of penetrating ballistic-like brain injury (PBBI). AMP cells were labeled with fluorescent dye PKH26 and injected in rats immediately following right hemispheric PBBI or sham PBBI surgery by ipsilateral i.c.v. administration. At 2 weeks post-injury, severe necrosis developed along the PBBI tract and axonal degeneration was prominent along the corpus callosum (cc) and in the ipsilateral thalamus. Injected AMP cells first entered the subventricular zone (SVZ) in both sham and PBBI rats. Further AMP cell migration along the cc only occurred in PBBI animals. No significant difference in injury volume was observed across all treatment groups. In contrast, treatment with AMP cells significantly attenuated axonal degeneration in both the thalamus and the cc. Interestingly, PKH26-labeled AMP cells were detected only in the SVZ and the cc (in parallel with the axonal degeneration), but not in the thalamus. None of the labeled AMP cells appeared to express neural differentiation, as evidenced by the lack of double labeling with nestin, S-100, GFAP, and MAP-2 immunostaining. In conclusion, AMP cell migration was specifically induced by PBBI and requires SVZ homing, yet the neuroprotective effect of intracerebral ventrical treatment using AMP cells was not limited to the area where the cells were present. This suggests that the attenuation of the secondary brain injury following PBBI was likely to be mediated by mechanisms other than cell replacement, possibly through delivery or sustained secretion of neurotrophic factors. C1 [Chen, Zhiyong; Tortella, Frank C.; Dave, Jitendra R.; Lu, X. -C. May] Walter Reed Army Inst Res, Dept Appl Neurobiol, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Marshall, Vivienne S.; Clarke, Diana L.; Sing, George] Stemnion Inc, Pittsburgh, PA USA. [Du, Fu] FD NeuroTechnol Inc, Ellicott City, MD USA. RP Chen, ZY (reprint author), Walter Reed Army Inst Res, Dept Appl Neurobiol, Div Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Zhiyong.chen@amedd.army.mil NR 38 TC 17 Z9 17 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD NOV PY 2009 VL 26 IS 11 BP 1987 EP 1997 DI 10.1089/neu.2008.0863 PG 11 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 523CO UT WOS:000272049600014 PM 19886807 ER PT J AU Li, YJ Pritchett, TM Shao, P Haley, JE Zhu, HJ Sun, WF AF Li, Yunjing Pritchett, Timothy M. Shao, Pin Haley, Joy E. Zhu, Hongjun Sun, Wenfang TI Excited-state absorption of mono-, di- and tri-nuclear cyclometalated platinum 4,6-diphenyl-2,2 '-bipyridyl complexes SO JOURNAL OF ORGANOMETALLIC CHEMISTRY LA English DT Article DE Triplet excited-state absorption cross-section; Singlet excited-state absorption cross-section; Excited-state lifetime; Triplet quantum yield; Cyclometalated platinum(II) 4,6-diphenyl-2,2 '-bipyridyl complexes; Z-scan ID PHOTOPHYSICS AB The ground-state absorption cross-sections (sigma(g)), triplet excited-state absorption cross-section (sigma(T)) at 532 nm, singlet excited-state absorption cross-sections (sigma(s)) at various visible wavelengths, singlet and triplet excited-state lifetimes, and triplet quantum yields of three cyclometalated platinum(II) 4,6-diphenyl-2,2'-bipyridyl complexes, are reported. The presence of metal-metal and pi-pi interactions in the dinuclear and trinuclear complexes results in a significant increase in their respective sigma(g)'s in the visible spectral region. As a result, the ratio of sigma(s)/sigma(g) and sigma(T)/sigma(g) at each wavelength is significantly greater for the mononuclear complex than for the dinuclear and the trinuclear complexes. (C) 2009 Elsevier B.V. All rights reserved. C1 [Li, Yunjing; Shao, Pin; Zhu, Hongjun; Sun, Wenfang] N Dakota State Univ, Dept Chem & Mol Biol, Fargo, ND 58108 USA. [Pritchett, Timothy M.] USA, Res Lab, AMSRD ARL SE EM, Adelphi, MD 20783 USA. [Haley, Joy E.] USAF, Res Lab, Mat & Mfg Directorate, Wright Patterson AFB, OH 45433 USA. [Haley, Joy E.] Universal Energy Syst Inc, Dayton, OH 45432 USA. RP Sun, WF (reprint author), N Dakota State Univ, Dept Chem & Mol Biol, Fargo, ND 58108 USA. EM Wenfang.Sun@ndsu.edu RI shao, pin/D-5790-2011 FU NSF [CHE-0449598]; Army Research Laboratory [W911NF-06-2-0032] FX W. Sun acknowledges the financial support from the NSF (CAREER CHE-0449598) and the Army Research Laboratory (W911NF-06-2-0032). NR 11 TC 11 Z9 11 U1 2 U2 7 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0022-328X J9 J ORGANOMET CHEM JI J. Organomet. Chem. PD NOV 1 PY 2009 VL 694 IS 23 BP 3688 EP 3691 DI 10.1016/j.jorganchem.2009.07.045 PG 4 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA 501GN UT WOS:000270369400002 ER PT J AU Teyhen, DS Bluemle, LN Dolbeer, JA Baker, SE Molloy, JM Whittaker, J Childs, JD AF Teyhen, Deydre S. Bluemle, Laura N. Dolbeer, Jeffery A. Baker, Sarah E. Molloy, Joseph M. Whittaker, Jackie Childs, John D. TI Changes in Lateral Abdominal Muscle Thickness During the Abdominal Drawing-in Maneuver in Those With Lumbopelvic Pain SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE internal oblique; lumbar stabilization exercise; sacroiliac dysfunction; transversus abdominis; ultrasound imaging ID LOW-BACK-PAIN; POSTERIOR PELVIC PAIN; LEG RAISE TEST; FEEDFORWARD POSTURAL RESPONSES; RANDOMIZED CONTROLLED-TRIAL; FEAR-AVOIDANCE BELIEFS; SACROILIAC JOINT PAIN; TRANSVERSUS ABDOMINIS; PROVOCATION TESTS; LUMBAR SPINE AB STUDY DESIGN: Controlled laboratory study. OBJECTIVES: To determine if changes in transversus abdominis (TrA) and internal oblique (10) muscle thickness and side-to-side symmetry differ in individuals with and without unilateral lumbopelvic pain while at rest and during the abdominal drawing-in maneuver (ADIM). BACKGROUND: Although the ADIM has been found to produce a symmetrical change in TrA and 10 muscle thickness in healthy subjects, how these muscles are activated in those with unilateral lumbopelvic pain during the ADIM remains unknown. METHODS: Fifteen subjects with lumbopelvic pain and 15 age- and gender-matched control subjects were recruited. To investigate a similar subgroup of patients with lumbopelvic pain that has been used in previous research, subjects were required to have unilateral symptoms, a positive sacroiliac provocation test, and a positive active straight-leg raise test. Ultrasound images were obtained bilaterally at 2 different points during each trial of the ADIM: (1) at rest and (2) while maintaining the ADIM. Average percent change in thickness of the TrA and 10 muscles was obtained over 3 trials. RESULTS: The percent change in thickness of the TrA was 20.9% less in those with lumbopelvic pain compared to the control group (P = .035), while the percent change in 10 thickness was equivalent between groups (P = .522). No differences were observed for the TrA or 10 muscles between the symptomatic and asymptomatic sides in those with (TrA, P = .263; 10, P = .172) or without (TrA, P = .780; 10, P = .635) lumbopelvic pain during the ADIM. Changes in TrA muscle thickness were greater than the 10 muscle during the ADIM for both groups (P<001). Specifically, the increases in TrA muscle thickness in those with and without lumbopelvic dysfunction were 32.7% and 47.3% greater, respectively, compared to changes in the 10 muscle. CONCLUSIONS: Individuals with unilateral lumbopelvic pain demonstrated a smaller increase in thickness of the TrA muscle during the ADIM. This finding provides an element of construct validity for the use of the ADIM for assessing TrA muscle thickness in those with unilateral lumbopelvic pain. However, both groups demonstrated a symmetrical side-to-side change in TrA and 10 muscle thickness despite the symptomatic group having unilateral symptoms. Further, we detected a preferential change in TrA muscle thickness during the ADIM in both groups. J Cirthop Sports Phys Ther 2009;39(11):791-798. doi:10.2519/jospt.2009.3128 C1 [Teyhen, Deydre S.; Childs, John D.] Baylor Univ, USA, Doctoral Program Phys Therapy, San Antonio, TX USA. [Teyhen, Deydre S.] Ctr Phys Therapy Res, San Antonio, TX USA. [Bluemle, Laura N.] William Beaumont Army Med Ctr, El Paso, TX 79920 USA. [Dolbeer, Jeffery A.] Womack Army Med Ctr, Ft Bragg, NC USA. [Baker, Sarah E.] Kimbrough Ambulatory Care Ctr, Musculoskeletal Clin, Ft George G Meade, MD USA. [Molloy, Joseph M.] Brooke Army Med Ctr, Phys Therapy Serv, San Antonio, TX USA. [Whittaker, Jackie] Whittaker Physiotherapy Consulting, White Rock, BC, Canada. [Whittaker, Jackie] Univ Southampton, Sch Hlth Sci, Southampton, Hants, England. RP Teyhen, DS (reprint author), USA, Dept Phys Therapy, Med Dept Ctr & Sch, 3150 Stanley Rd,Room 1303,ATTN MCCS HGE PT, Ft Sam Houston, TX 78234 USA. EM deydre.teyhen@amedd.army.mil NR 65 TC 39 Z9 40 U1 1 U2 15 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD NOV PY 2009 VL 39 IS 11 BP 791 EP 798 DI 10.2519/jospt.2009.3128 PG 8 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 517FK UT WOS:000271598400002 PM 19881003 ER PT J AU Gill, NW AF Gill, Norman W. TI "Centralization" and "Directional Preference" Are Not Synonymous RESPONSE SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Letter C1 [Gill, Norman W.] Baylor Univ, USA, Postprofess Doctoral Program Orthoped Manual Phys, Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Gill, Norman W.] Tuttle Army Hlth Clin, Hunter Army Airfield, GA USA. RP Gill, NW (reprint author), Baylor Univ, USA, Postprofess Doctoral Program Orthoped Manual Phys, Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD NOV PY 2009 VL 39 IS 11 BP 827 EP 828 PG 2 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 517FK UT WOS:000271598400009 ER PT J AU Royer, PJ Kane, EJ Parks, KE Morrow, JC Moravec, RR Christie, DS Teyhen, DS AF Royer, Philip J. Kane, Edward J. Parks, Kyle E. Morrow, Jacob C. Moravec, Richard R. Christie, Douglas S. Teyhen, Deydre S. TI Fluoroscopic assessment of rotator cuff fatigue on glenohumeral arthrokinematics in shoulder impingement syndrome SO JOURNAL OF SHOULDER AND ELBOW SURGERY LA English DT Article DE Rotator cuff; shoulder impingement syndrome; outlet impingement; glenohumeral; fluoroscopy; fatigue; impingement; arthrokinematics ID SUPERIOR GLENOID IMPINGEMENT; SUBACROMIAL IMPINGEMENT; SCAPULOHUMERAL RHYTHM; THROWING ATHLETE; KINEMATICS; MOTION; JOINT; INSTABILITY; STRENGTH; MUSCLES AB Background: Although prior researchers have assessed glenohumeral arthrokinematics using isometrically held arm postures with standard radiographs, dynamic assessment of glenohumeral arthrokinematics has been limited. This study utilized video fluoroscopy to analyze superior inferior glenohumeral migration during dynamic arm elevation in individuals with outlet impingement syndrome, before and after fatigue of the rotator cuff. Hypothesis: Prior to the study, it was hypothesized that during the pre-fatigue state, glenohumeral migration would be in the superior direction, and that post-fatigue there would be a significant increase in superior migration. Materials and methods: Digital fluoroscopic videos (30 Hz) were used to analyze 20 male volunteers (27.7 +/- 7.3 years) with right shoulder outlet impingement syndrome during concentric elevation of the arm in the plane of the scapula, both before and after fatigue of the rotator cuff. Results: During concentric arm elevation, there was superior glenohumeral migration (1.6 mm) between 45 degrees and 90 degrees of arm elevation, regardless of fatigue-state (P=.02). After rotator cuff fatigue, the humeral head was positioned more superiorly on the glenoid fossa (P=.03). The position of the humeral head was 0.4 mm more superior than that reported in a previous study on healthy individuals. Conclusion: These results support prior findings that suggest superior glenohumeral migration during arm elevation is influenced both by shoulder pathology and the state of fatigue of the rotator cuff musculature. Future research should examine the effects of physical therapy and surgical interventions on glenohumeral arthrokinematics to better determine the most effective treatment methods for outlet impingement. Level of evidence: Controlled laboratory Study (C) 2009 Journal of Shoulder and Elbow Surgery Board of Trustees. C1 [Royer, Philip J.] US Army Hlth Clin, Phys Therapy Dept, Vicenza, Italy. [Kane, Edward J.] Univ St Augustine, Phys Therapy Dept, Bernardo, CA USA. [Parks, Kyle E.] Irwin Army Community Hosp, Phys Therapy Dept, Ft Riley, KS USA. [Morrow, Jacob C.] Evans Army Community Hosp, Phys Therapy Dept, Ft Carson, CO USA. [Moravec, Richard R.] Tuttle Army Hlth Clin, Phys Therapy Dept, Hunter Army Airfield, GA USA. [Christie, Douglas S.; Teyhen, Deydre S.] Baylor Univ, USA, Doctoral Program Phys Therapy, Ft Sam Houston, TX USA. EM phil.royer@us.army.mil NR 46 TC 19 Z9 19 U1 0 U2 6 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 1058-2746 J9 J SHOULDER ELB SURG JI J. Shoulder Elbow Surg. PD NOV-DEC PY 2009 VL 18 IS 6 BP 968 EP 975 DI 10.1016/j.jse.2009.03.002 PG 8 WC Orthopedics; Sport Sciences; Surgery SC Orthopedics; Sport Sciences; Surgery GA 513FY UT WOS:000271309100021 PM 19427234 ER PT J AU DeSpirito, J Silton, SI Weinacht, P AF DeSpirito, James Silton, Sidra I. Weinacht, Paul TI Navier-Stokes Predictions of Dynamic Stability Derivatives: Evaluation of Steady-State Methods SO JOURNAL OF SPACECRAFT AND ROCKETS LA English DT Article; Proceedings Paper CT AIAA 46th Aerospace Sciences Meeting and Exhibit CY JAN 07-10, 2008 CL Reno, NV SP Amer Inst Aeronaut & Astronaut ID COMPUTATIONAL FLUID-DYNAMICS; PROJECTILE AB The prediction of the dynamic stability derivatives, roll damping, Magnus moments, and pitch-damping moments were evaluated for three spin-stabilized projectiles using steady-state computational fluid dynamic calculations. Roll-damping computational fluid dynamic predictions were found to be very good across the Mach number range investigated. Magnus moment predictions were very good in the supersonic flight regime but the accuracy varied in the sub- and transonic flight regime. The best Magnus moment prediction in the subsonic flight regime was for the non-boat-tailed projectile that did not exhibit highly nonlinear Magnus moments. A primary contribution of this paper is the demonstration that the pitch-damping moment can be adequately predicted via steady-state methods, rather than resorting to unsteady techniques. The predicted pitch-damping moment compared very well with experimental data for the three projectiles investigated. For one configuration, the pitch-damping moment was predicted by several computational fluid dynamic codes, two different steady-state methods, and a time-accurate planar pitching motion method. All methods compared very well with each other and to the experimental data. C1 [DeSpirito, James; Silton, Sidra I.; Weinacht, Paul] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP DeSpirito, J (reprint author), USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. NR 38 TC 12 Z9 14 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0022-4650 J9 J SPACECRAFT ROCKETS JI J. Spacecr. Rockets PD NOV-DEC PY 2009 VL 46 IS 6 BP 1142 EP 1154 DI 10.2514/1.38666 PG 13 WC Engineering, Aerospace SC Engineering GA 534NE UT WOS:000272903600007 ER PT J AU Phatak, SA Yoon, YS Gooler, DM Allen, JB AF Phatak, Sandeep A. Yoon, Yang-Soo Gooler, David M. Allen, Jont B. TI Consonant recognition loss in hearing impaired listeners SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID SPEECH-RECEPTION THRESHOLD; NONSENSE-SYLLABLE TEST; OLDER-ADULTS; NOISE; CONFUSIONS; PERCEPTION; MODEL; FEATURES; PHONEME; BENEFIT AB This paper presents a compact graphical method for comparing the performance of individual hearing impaired (HI) listeners with that of an average normal hearing (NH) listener on a consonant-by-consonant basis. This representation, named the consonant loss profile (CLP), characterizes the effect of a listener's hearing loss on each consonant over a range of performance. The CLP shows that the consonant loss, which is the signal-to-noise ratio (SNR) difference at equal NH and HI scores, is consonant-dependent and varies with the score. This variation in the consonant loss reveals that hearing loss renders some consonants unintelligible, while it reduces noise-robustness of some other consonants. The conventional SNR-loss metric Delta SNR(50), defined as the SNR difference at 50% recognition score, is insufficient to capture this variation. The Delta SNR(50) value is on average 12 dB lower when measured with sentences using standard clinical procedures than when measured with nonsense syllables. A listener with symmetric hearing loss may not have identical CLPs for both ears. Some consonant confusions by HI listeners are influenced by the high-frequency hearing loss even at a presentation level as high as 85 dB sound pressure level. (C) 2009 Acoustical Society of America. [DOI: 10.1121/1.3238257] C1 [Phatak, Sandeep A.] Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, Washington, DC 20307 USA. [Yoon, Yang-Soo] House Ear Res Inst, Los Angeles, CA 90057 USA. [Gooler, David M.] Univ Illinois, Dept Speech & Hearing Sci, Champaign, IL 61820 USA. [Allen, Jont B.] Univ Illinois, ECE Dept, Urbana, IL 61801 USA. [Allen, Jont B.] Univ Illinois, Beckman Inst Adv Sci & Technol, Urbana, IL 61801 USA. RP Phatak, SA (reprint author), Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, Washington, DC 20307 USA. FU NIDCD [R03-DC06810]; Clinical Investigation Regulatory Office; U. S. Army Medical Department and School and the Oticon Foundation, Copenhagen, Denmark FX This research was supported by a University of Illinois grant. Partial salary support was provided by NIDCD (No. R03-DC06810) and by Cooperative Research and Development Agreements between the Clinical Investigation Regulatory Office, U. S. Army Medical Department and School and the Oticon Foundation, Copenhagen, Denmark. The opinions and assertions presented are the private views of the authors and are not to be construed as official or as necessarily reflecting the views of the Department of the Army, or the Department of Defense. The data collection expenses were covered through research funds provided by Etymotic Research and Phonak. Portions of this work were presented at the IHCON Meeting (Lake Tahoe, CA) in 2006, at the ARO Midwinter Meeting (Denver, CO), the AAS Conference (Scottsdale, AZ), and the Aging and Speech Communication Conference (Bloomington, IN) in 2007, and in the Department of Hearing and Speech Science Winter Workshop at the University of Maryland (College Park, MD) in 2008. We thank Ken Grant and Harvey Abrams for informative discussions and insights. Mary Cord and Matthew Makashay helped in QuickSIN level measurements. NR 35 TC 13 Z9 14 U1 1 U2 2 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD NOV PY 2009 VL 126 IS 5 BP 2683 EP 2694 DI 10.1121/1.3238257 PG 12 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 515XU UT WOS:000271507000063 PM 19894845 ER PT J AU Walden, TC Walden, BE Summers, V Grant, KW AF Walden, Therese C. Walden, Brian E. Summers, Van Grant, Ken W. TI A Naturalistic Approach to Assessing Hearing Aid Candidacy and Motivating Hearing Aid Use SO JOURNAL OF THE AMERICAN ACADEMY OF AUDIOLOGY LA English DT Article DE Candidacy; everyday listening; hearing aids ID AMPLIFICATION AB Background: Although the benefits of amplification for persons with impaired hearing are well established, many potential candidates do not obtain and use hearing aids. In some cases, this is because the individual is not convinced that amplification will be of sufficient benefit in those everyday listening situations where he or she is experiencing difficulties. Purpose: To describe the development of a naturalistic approach to assessing hearing aid candidacy and motivating hearing aid use based on patient preferences for unamplified and amplified sound samples typical of those encountered in everyday living and to assess the validity of these preference ratings to predict hearing aid candidacy. Research Design: Prospective experimental study comparing preference ratings for unamplified and amplified sound samples of patients with a clinical recommendation for hearing aid use and patients for whom amplification was not prescribed. Study Sample: Forty-eight adults self-referred to the Army Audiology and Speech Center for a hearing evaluation. Data Collection and Analysis: Unamplified and amplified sound samples were presented to potential hearing aid candidates using a three-alternative forced-choice paradigm. Participants were free to switch at will among the three processing options (no gain, mild gain, moderate gain) until the preferred option was determined. Following this task, each participant was seen for a diagnostic hearing evaluation by one of eight staff audiologists with no knowledge of the preference data. Patient preferences for the three processing options. were used to predict the attending audiologists' recommendations for amplification based on traditional audiometric measures. Results: Hearing aid candidacy was predicted with moderate accuracy from the patients' preferences for amplified sounds typical of those encountered in everyday living, although the predictive validity of the various sound samples varied widely. Conclusions: Preferences for amplified sounds were generally predictive of hearing aid candidacy. However, the predictive validity of the preference ratings was not sufficient to replace traditional clinical determinations of hearing aid candidacy in individual patients. Because the sound samples are common to patients' everyday listening experiences, they provide a quick and intuitive method of demonstrating the potential benefit of amplification to patients who might otherwise not accept a prescription for hearing aids. C1 [Walden, Therese C.; Walden, Brian E.; Summers, Van; Grant, Ken W.] Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, Washington, DC 20307 USA. RP Walden, TC (reprint author), Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM therese.walden@amedd.army.mil NR 28 TC 3 Z9 4 U1 2 U2 8 PU AMER ACAD AUDIOLOGY PI RESTON PA 11730 PLAZA DR, STE 300, RESTON, VA 20190 USA SN 1050-0545 J9 J AM ACAD AUDIOL JI J. Am. Acad. Audiol. PD NOV-DEC PY 2009 VL 20 IS 10 BP 607 EP 620 DI 10.3766/jaaa.20.10.3 PG 14 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 522GQ UT WOS:000271986300003 PM 20503799 ER PT J AU Marx, BP Doron-Lamarca, S Proctor, SP Vasterling, JJ AF Marx, Brian P. Doron-Lamarca, Susan Proctor, Susan P. Vasterling, Jennifer J. TI The influence of pre-deployment neurocognitive functioning on post-deployment PTSD symptom outcomes among Iraq-deployed Army soldiers SO JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY LA English DT Article DE Visual memory; Verbal memory; Attention; Neurocognitive functioning; PTSD; Combat ID POSTTRAUMATIC-STRESS-DISORDER; GULF-WAR VETERANS; PREFRONTAL CORTEX; COGNITIVE-ABILITY; VIETNAM VETERANS; RISK-FACTORS; AUTOBIOGRAPHICAL MEMORY; PSYCHOMETRIC PROPERTIES; HIPPOCAMPAL VOLUME; TWINS DISCORDANT AB This study evaluated associations between pre-deployment neurocognitive performance and post-deployment posttraumatic stress disorder (PTSD) symptoms in a sample of deployed active duty Army soldiers. As part of a larger longitudinal study, each participant completed baseline measures of memory, executive attention, and response inhibition, and baseline and post-deployment self-report measures of PTSD symptom severity. Data were subjected to multiple regression analyses that examined associations between baseline neurocognitive performances and longitudinal PTSD symptom outcome. Results revealed that pre-trauma immediate recall Of Visual information was associated with post-deployment PTSD symptom severity, even after controlling for pre-deployment PTSD symptom levels, combat intensity, age, gender, and test-retest interval. There was also an interaction between pre-deployment PTSD symptom severity and pre-deployment immediate visual recall and Verbal learning, indicating that neurocognitive performances were more strongly (and negatively) associated with residualized post-deployment PTSD symptoms at higher levels of pre-deployment PTSD symptoms. These findings highlight the potential role of pre-trauma neurocognitive functioning in moderating the effects of trauma exposure on PTSD symptoms. (JINS, 2009 15, 840-852.) C1 [Marx, Brian P.; Doron-Lamarca, Susan; Vasterling, Jennifer J.] VA Boston Healthcare Syst, Behav Sci Div, Natl Ctr PTSD, Boston, MA 02130 USA. [Marx, Brian P.; Doron-Lamarca, Susan; Proctor, Susan P.; Vasterling, Jennifer J.] VA Boston Healthcare Syst, Dept Psychol, Boston, MA 02130 USA. [Marx, Brian P.; Doron-Lamarca, Susan; Vasterling, Jennifer J.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA. [Proctor, Susan P.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Proctor, Susan P.] Boston Univ, Sch Med, Dept Environm Hlth, Boston, MA 02118 USA. RP Marx, BP (reprint author), VA Boston Healthcare Syst, Natl Ctr PTSD 116B2, 150 S Huntington Ave, Boston, MA 02130 USA. EM brain.marx@va.gov FU U.S. Army Medical Research and Materiel Command [17-03-0020, A-11815]; VA Clinical Sciences Research and Development; South Central Mental Illness Research, Education, and Clinical Center; U.S. Army Research Institute for Environmental Medicine; U.S. Army Medical Research Acquisition Activity [DAMD 17-03-0020] FX This work was Supported by the U.S. Army Medical Research and Materiel Command (DAMD 17-03-0020; HSRRB Log No. A-11815) and VA Clinical Sciences Research and Development awards. The work also was Supported in part by resources provided by the South Central Mental Illness Research, Education, and Clinical Center and U.S. Army Research Institute for Environmental Medicine. Some of the work was completed at the Southeast Louisiana Veterans Healthcare System and Tulane University. The U.S. Army Medical Research Acquisition Activity (Fort Detrick, MD) is the awarding and administering acquisition office for DAMD 17-03-0020 NR 88 TC 31 Z9 31 U1 3 U2 13 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1355-6177 J9 J INT NEUROPSYCH SOC JI J. Int. Neuropsychol. Soc. PD NOV PY 2009 VL 15 IS 6 BP 840 EP 852 DI 10.1017/S1355617709990488 PG 13 WC Clinical Neurology; Neurosciences; Psychiatry; Psychology SC Neurosciences & Neurology; Psychiatry; Psychology GA 523ZV UT WOS:000272114500004 PM 19891817 ER PT J AU Vollmerhausen, RH Driggers, RG Wilson, DL AF Vollmerhausen, Richard H. Driggers, Ronald G. Wilson, David L. TI Predicting range performance of sampled imagers by treating aliased signal as target-dependent noise (vol 25, pg 2055, 2008) SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Correction C1 [Driggers, Ronald G.; Wilson, David L.] US Army Res Dev & Engn Command, Commun Elect Res Dev & Engn Ctr, Night Vis & Elect Sensors Directorate, Belvoir, VA 22060 USA. RP Vollmerhausen, RH (reprint author), 760 Jacktown Rd, Lexington, VA 24450 USA. EM vollmerhausen@hughes.net NR 3 TC 1 Z9 1 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1084-7529 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD NOV PY 2009 VL 26 IS 11 BP 2418 EP 2418 PG 1 WC Optics SC Optics GA 524LA UT WOS:000272143600032 ER PT J AU Holley, AB Cheatham, JG Jackson, JL Moores, LK Villines, TC AF Holley, Aaron B. Cheatham, Joseph G. Jackson, Jeffrey L. Moores, Lisa K. Villines, Todd C. TI Novel quantitative echocardiographic parameters in acute PE SO JOURNAL OF THROMBOSIS AND THROMBOLYSIS LA English DT Article DE Echocardiography; Pulmonary embolism; Right ventricular infarction ID ACUTE PULMONARY-EMBOLISM; BRAIN NATRIURETIC PEPTIDE; RIGHT-VENTRICULAR DYSFUNCTION; TRICUSPID ANNULAR MOTION; MYOCARDIAL-INFARCTION; RISK STRATIFICATION; TROPONIN-T; DISEASE; PRESSURE AB Background The tricuspid annular plane systolic excursion (TAPSE) and the right ventricular performance index (RVPI) are quantitative measurements that are valid predictors of clinical outcomes in CHF, MI, PAH, and chronic pulmonary disease. We sought to measure TAPSE and RVPI in patients diagnosed with acute pulmonary embolism (APE) to assess for correlation with known predictors of clinical outcomes. Methods Patients admitted with APE had echocardiograms performed within 24 h of diagnosis and B-type natriuretic peptide (BNP) drawn on admission. Serial troponins were measured for the first 48 h of the hospital stay, and clinical course was followed until discharge. Results A total of 29 patients were enrolled in the study. Compared to those with a normal study, significantly more patients with an abnormal TAPSE had an elevated BNP (60% vs. 5%; P = 0.004) and troponin (50% vs. 11.1%; P = 0.042). The mean TAPSE was 22.3 mm when BNP was normal and 17.4 mm when elevated (P = 0.003). TAPSE values were significantly lower in patients with abnormal RV function by echocardiogram graded by a blinded cardiologist (17.6 mm vs. 21.7 mm; P = 0.03). Both TAPSE and RVPI correlated significantly with septal flattening, RVEDD, and RVEDD/LVEDD by echo. Conclusions TAPSE has good correlation with surrogate markers for morbidity and mortality in APE, and both TAPSE and RVPI seem to perform as well as the standard echo parameters used to assess RV function. Both are objective and easy to measure, and therefore warrant prospective study in larger patient groups, with assessment of clinical outcomes. C1 [Holley, Aaron B.; Cheatham, Joseph G.; Jackson, Jeffrey L.; Moores, Lisa K.; Villines, Todd C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Holley, AB (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM aaron.holley@NA.amedd.army.mil; joseph.cheatham@us.army.mil; jeffrey.jackson@NA.amedd.army.mil; lisa.moores@NA.amedd.army.mil; todd.villines@NA.amedd.army.mil OI Villines, Todd/0000-0003-2674-3702 NR 24 TC 9 Z9 9 U1 0 U2 1 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0929-5305 J9 J THROMB THROMBOLYS JI J. Thromb. Thrombolysis PD NOV PY 2009 VL 28 IS 4 BP 506 EP 512 DI 10.1007/s11239-009-0322-6 PG 7 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA 510HS UT WOS:000271079400019 PM 19283447 ER PT J AU Pidcoke, HF Wanek, SM Rohleder, LS Holcomb, JB Wolf, SE Wade, CE AF Pidcoke, Heather F. Wanek, Sandra M. Rohleder, Laura S. Holcomb, John B. Wolf, Steven E. Wade, Charles E. TI Glucose Variability is Associated With High Mortality After Severe Burn SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 37th Annual Meeting of the Western-Trauma-Association CY FEB 25-MAR 02, 2007 CL Steamboat Springs, CO SP Western Trauma Assoc DE Glucose variability; Glycemic control; Intensive insulin; Trauma; Hyperglycemia; Mortality; Critical care ID CRITICALLY-ILL PATIENTS; TRAUMA PATIENTS; ADMISSION HYPERGLYCEMIA; INTENSIVE INSULIN; GLYCEMIC CONTROL; CRITICAL ILLNESS; BLOOD-SUGAR; SURVIVAL; THERAPY; CARE AB Background: Hyperglycemia is associated with increased mortality in the severely injured; intensive insulin protocols reduce mortality, improve wound healing, and decrease susceptibility to infection. High glucose variability creates challenges to lycemic control and may be a marker of poor outcome. We wondered whether glycemic variability alone might identify patients at higher risk of death. Methods: Burn patients admitted in 2005 with >20% total body surface area burned, > 100 glucose measurements, and one hypo- and hyperglycemic event were included in the analysis; all were treated with intensive insulin (glycemic target: 80-110 mg/dL). Glycemic variability was the sum of percent excursions (defined as values <80 mg/dL or >110 mg/dL); variability above the mean was considered high. Results: Individual average variability in the 49 subjects was 50% +/- 8% (range, 30-65%); the average number of glucose measurements per patient was 840 (range, 103-5314). Percent excursions in those with high (n = 26) compared with low (n = 23) variability scores was 56% +/- 6% and 43% +/- 5% (p < 0.001), respectively. No difference was found between groups in injury severity score, age, total body surface area burned, full thickness burns, gender, or inhalation injury. Both groups were similar for days of ventilator support, intensive care unit stay, and hospital stay. Mortality in the highly variable group was twice that of the less variable group (50% vs. 22%, p = 0.041). Conclusions: High glucose variability (>50% of values outside 80-110 mg/dL) is associated with increased mortality in the severely burned. Individuals with frequent excursions outside the glucose target range of 80 mg/dL to 110 mg/dL are at greater risk of death. C1 [Pidcoke, Heather F.; Wanek, Sandra M.; Rohleder, Laura S.; Holcomb, John B.; Wolf, Steven E.; Wade, Charles E.] USA, Inst Surg Res, Brooke Army Med Ctr, San Antonio, TX 78234 USA. [Pidcoke, Heather F.; Wolf, Steven E.; Wade, Charles E.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA. RP Pidcoke, HF (reprint author), USA, Inst Surg Res, Brooke Army Med Ctr, 3400 Rawley E Chambers Ave, San Antonio, TX 78234 USA. EM heather.pidcoke@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 FU NIGMS NIH HHS [1 R01 GM063120] NR 35 TC 34 Z9 35 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD NOV PY 2009 VL 67 IS 5 BP 990 EP 995 DI 10.1097/TA.0b013e3181baef4b PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 518XO UT WOS:000271729500015 PM 19901659 ER PT J AU Ishihara, S Ward, JA Tasaki, O Pruitt, BA Mozingo, DW AF Ishihara, Satoshi Ward, John A. Tasaki, Osamu Pruitt, Basil A., Jr. Mozingo, David W. TI Cardiac Contractility During Hemofiltration in an Awake Model of Hyperdynamic Endotoxemia SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE LV function; Endotoxin; Hemofiltration; Catecholamines ID CONTINUOUS ARTERIOVENOUS HEMOFILTRATION; CONTINUOUS VENOVENOUS HEMOFILTRATION; VENTRICULAR CONTRACTILITY; SEPTIC SHOCK; SEPSIS; DIALYSIS; THERAPY; VOLUME; DOGS AB Background: To determine whether continuous veno-venous hemofiltration can ameliorate hemodynamic instability and left ventricular (LV) dysfunction by reducing circulating plasma mediators, the authors used the LV end-systolic elastance (Ees) as a contractility index, in an awake swine model simulating human hyperdynamic endotoxemia. Methods: Nineteen instrumented pigs were divided into a control group (CTRL, n = 7), a hemofiltration (HF, n = 7) group, and an extracorporeal circuit (ECC, n = 5) only group. All animals received intravenous E. coli endotoxin (10 mu g . kg(-1) . h(-1)) and resuscitation in a common regimen for 24 hours. Hemofiltration was started 30 minutes after initiation of endotoxemia and continued until the end of the experiment. Results: Ees was maintained at baseline levels in the HF group, whereas a progressive decrease of Ees was found in both the CTRL and the ECC groups. Cardiac output was significantly higher in the HF group than the CTRL group. There was no significant difference between the groups in plasma catecholamines. Conclusion: We conclude that hemofiltration prevented LV impairment. C1 [Ishihara, Satoshi] Kawasaki Med Univ, Dept Acute Med, Okayama 7010192, Japan. [Ward, John A.] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. [Tasaki, Osamu] Osaka Univ, Fac Med, Osaka, Japan. [Pruitt, Basil A., Jr.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX USA. [Mozingo, David W.] Univ Florida, Shands Hosp, Dept Surg, Gainesville, FL USA. RP Ishihara, S (reprint author), Kawasaki Med Univ, Dept Acute Med, 577 Matsushima, Okayama 7010192, Japan. EM ishihara@med.kawasaki-m.ac.jp NR 16 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD NOV PY 2009 VL 67 IS 5 BP 1055 EP 1061 DI 10.1097/TA.0b013e3181a5f405 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 518XO UT WOS:000271729500025 PM 19901668 ER PT J AU Ervin, MH Nichols, BM AF Ervin, M. H. Nichols, B. M. TI Electron beam induced deposition of cobalt for use as single- and multiwalled carbon nanotube growth catalyst SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article DE carbon nanotubes; catalysts; chemical vapour deposition; cobalt; electron beam deposition; nanofabrication; nanoparticles; scanning electron microscopy ID GOLD; FABRICATION; SUBSTRATE AB Electron beam induced deposition (EBID) has been investigated by many researchers for a number of applications requiring maskless deposition of material. Here, a scanning electron microscope is used to perform EBID of cobalt (Co) nanoparticles, which are then used as the catalyst for selected-area growth of carbon nanotubes (CNTs). Co nanoparticles were deposited using cobalt tricarbonyl nitrosyl as the precursor. They are oxygen plasma ashed to remove residual carbon from the deposition process prior to the growth of CNTs using a chemical vapor deposition (CVD) process. Co deposits made using different doses were found to have different catalytic properties. At sufficiently low doses, the deposits were insufficient to catalyze any CNT growth. At higher doses, single-walled CNT (SWCNT) growth was observed. Still higher doses produced deposits that catalyzed multiwalled CNT growth as well as some SWCNT growth. These differences in catalytic behavior are believed to result from nanoparticle size variations between and within the deposits. As a result, by using EBID deposited catalyst, it is possible to not only control where CNTs grow but also the kind of CNTs (SW or MW) grown during a single CVD run. C1 [Ervin, M. H.; Nichols, B. M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Ervin, MH (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM mervin@arl.army.mil NR 18 TC 6 Z9 6 U1 0 U2 12 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD NOV PY 2009 VL 27 IS 6 BP 2982 EP 2985 DI 10.1116/1.3250259 PG 4 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA 533DS UT WOS:000272803400131 ER PT J AU Lee, SY Hamlet, AF Fitzgerald, CJ Burges, SJ AF Lee, Se-Yeun Hamlet, Alan F. Fitzgerald, Carolyn J. Burges, Stephen J. TI Optimized Flood Control in the Columbia River Basin for a Global Warming Scenario SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT-ASCE LA English DT Article ID WESTERN UNITED-STATES; CLIMATE-CHANGE SCENARIOS; WATER-RESOURCES; PACIFIC-NORTHWEST; HYDROLOGY; SNOWPACK; PRECIPITATION; TEMPERATURE; COLORADO; AMERICA AB Anticipated future temperature changes in the mountainous U. S. Pacific Northwest will cause reduced spring snow pack, earlier melt, earlier spring peak flow and lower summer flow in transient rain-snow and snowmelt dominant river basins. In the context of managed flood control, these systematic changes are likely to disrupt the balance between flood control and reservoir refill in existing reservoir systems. To adapt to these hydrologic changes, refill timing and evacuation requirements for flood control need to be modified. This work poses a significant systems engineering problem, especially for large, multiobjective water systems. An existing optimization/simulation procedure is refined for rebalancing flood control and refill objectives for the Columbia River Basin for anticipated global warming. To calibrate the optimization model for the 20th century flow, the objective function is tuned to reproduce the current reliability of reservoir refill, while providing comparable levels of flood control to those produced by current flood control practices. After the optimization model is calibrated using the 20th century flow the same objective function is used to develop flood control curves for a global warming scenario which assumes an approximately 2 C increase in air temperature. Robust decreases in system storage deficits are simulated for the climate change scenario when optimized flood rule curves replace the current flood control curves, without increasing monthly flood risks. C1 [Lee, Se-Yeun; Hamlet, Alan F.; Burges, Stephen J.] Univ Washington, Dept Civil & Environm Engn, Seattle, WA 98195 USA. [Fitzgerald, Carolyn J.] USA, Corps Engineers, Seattle, WA 98134 USA. [Hamlet, Alan F.] Univ Washington, CSES Climate Impacts Grp, Seattle, WA 98195 USA. RP Burges, SJ (reprint author), Univ Washington, Dept Civil & Environm Engn, Seattle, WA 98195 USA. EM leesy@u.washington.edu; hamleaf@u.washington.edu; carolyn.j.fitzgerald@usace.army.mil; sburges@u.washington.edu NR 29 TC 24 Z9 24 U1 1 U2 11 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9496 J9 J WATER RES PL-ASCE JI J. Water Resour. Plan. Manage.-ASCE PD NOV-DEC PY 2009 VL 135 IS 6 BP 440 EP 450 DI 10.1061/(ASCE)0733-9496(2009)135:6(440) PG 11 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA 508FG UT WOS:000270913800004 ER PT J AU Humbryd, CJ Irish, JL Rahoy, DS Alpern, RL Rackmales, DN AF Humbryd, Chelsea J. Irish, Jennifer L. Rahoy, Diane S. Alpern, Robert L. Rackmales, David N. TI Variable-Height Bulkhead Design Concept for Storm Flood Protection SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article AB Wave overtopping and subsequent flooding during coastal storms result in significant damages in many areas. However, balancing engineering design functionality with public and community desire to maintain beach and waterfront views are often a challenge. Here, a variable-height bulkhead design concept is introduced. This bulkhead is designed to rise and fall with floodwaters to achieve design overtopping protection while maintaining views during nonstorm conditions. In this technical note, the functional variable-height bulkhead design is presented and laboratory tested. The design requirement that the bulkhead rise and fall with water levels was validated through this testing. Experimental results indicate that the variable-height bulkhead provides overtopping protection comparable to that of a static vertical wall with the same freeboard, showing that the variable-height bulkhead concept is, in terms of overtopping, a viable alternative for coastal storm protection. Testing has been carried out mainly for low energy conditions occurring, for example, in coastal bays and harbors. Further testing is required to include higher-energy environments such as the open coast. Finally, testing the structural design of the system is of primary importance. C1 [Irish, Jennifer L.] Texas A&M Univ, Zachry Dept Civil Engn, Coastal & Ocean Engn Div, College Stn, TX 77843 USA. [Humbryd, Chelsea J.] MIT, Dept Civil & Environm Engn, Cambridge, MA 02139 USA. [Rahoy, Diane S.; Alpern, Robert L.; Rackmales, David N.] USA, Corps Engineers, New York, NY 10278 USA. RP Irish, JL (reprint author), Texas A&M Univ, Zachry Dept Civil Engn, Coastal & Ocean Engn Div, College Stn, TX 77843 USA. EM chumbyrd@mit.edu; jirish@civil.tamu.edu; diane.s.rahoy@usace.army.mil; robert.l.alpern@usace.army.mil; david.n.rackmales@usace.army.mil OI Irish, Jennifer/0000-0002-2429-5953 FU U.S. Army Corps of Engineers, New York District and Texas AM University FX The writers thank the entire Texas A&M University 2008 OCEN 410 class for their contributions to experimental setup and data collection. The writers thank Mr. John Reed, Mr. Dustin Young, and Mr. David Piazza for their contributions to experimental design and data collection. All work presented was funded by the U.S. Army Corps of Engineers, New York District and Texas A&M University. The use of trade names does not constitute an endorsement in the use of these products by the U.S. Government. The variable-height bulkhead design presented here is patent pending (U.S. Patent Application 12,006,757, "Hydrostatically Operated Variable Height Bulkhead," filed January 2, 2008). NR 8 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD NOV-DEC PY 2009 VL 135 IS 6 BP 296 EP 300 DI 10.1061/(ASCE)WW.1943-5460.0000001 PG 5 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA 508FF UT WOS:000270913600006 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Wandering Souls: Journeys with the Dead and the Living in Viet Nam SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD NOV 1 PY 2009 VL 134 IS 18 BP 72 EP 72 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 513UD UT WOS:000271348400150 ER PT J AU Childs, JD Teyhen, DS Benedict, TM Morris, JB Fortenberry, AD McQueen, RM Preston, JB Wright, AC Dugan, JL George, SZ AF Childs, John D. Teyhen, Deydre S. Benedict, Timothy M. Morris, Jamie B. Fortenberry, Andrew D. McQueen, Rene M. Preston, Janice B. Wright, Alison C. Dugan, Jessica L. George, Steven Z. TI Effects of Sit-up Training versus Core Stabilization Exercises on Sit-up Performance SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE FITNESS; LOW BACK PAIN; LUMBAR SPINE; PREVENTION; MILITARY ID LOW-BACK-PAIN; RANDOMIZED CONTROLLED-TRIAL; IMPROVEMENT; REGIMENS; QUALITY AB CHILDS. J. D., D S TEYHEN, T M BENEDICT, J B MORRIS, A D FORTENBERRY, R M MCQUEEN, J B. PRESTON, A C WRIGHT, J I. DUGAN, and S Z. GEORGE Effects of Sit-up Training versus Core Stabilization Exercises on Sit-up Performance. Med Sci Sports Exerc., Vol 41. No. 11. pp 2072-2083, 2009 Purpose. Core stabilization exercises target abdominal and trunk muscles without the excessive loading that occurs during sit-ups However, core stabilization exercise programs (CSEP) have not been widely adopted in the US Army partially because of the perceived deleterious impact they would have on performance during the Army Physical Fitness Test. The purpose was to determine whether performing CSEP in lieu of sit-ups during unit physical training would have detrimental effects on sit-up performance and passing rates on the fitness test Methods Soldiers (N = 2616) between 18 and 35 yr of age were randomized to receive a traditional exercise program (TEP) with sit-ups or CSEP. Subjects with a previous history of low back pain or other injury precluding participation in training were excluded The training programs were completed four times per week for 12 wk Performance was assessed at baseline and after 12 wk Results. Both groups demonstrated significant improvements in sit-up performance and overall fitness scores over time (P < 0.001). There were no significant between-group differences in overall Fitness scores (P = 0.142) or sit-up performance (P = 0.543). However, CSEP resulted in a Significant improvement in sit-up passing rates by 5.6% compared with 3.9% for the TEP group (P = 0 004). Conclusions. CSEP did not have a detrimental impact on sit-up performance or overall fitness scores or pass rates. There was a small but significantly greater increase in sit-up pass rate in the CSEP (5.6%) versus the TEP group (3.9%). Incorporating CSEP into Army physical training does not increase the risk of suboptimal performance on the Army's fitness test and may offer a small benefit for improving sit-up performance C1 [Childs, John D.; Teyhen, Deydre S.; Benedict, Timothy M.; Morris, Jamie B.; Fortenberry, Andrew D.; McQueen, Rene M.; Preston, Janice B.; Wright, Alison C.; Dugan, Jessica L.] Baylor Univ, USA, Doctoral Program Phys Therapy MCCS HMT, Army Med Dept, Ft Sam Houston, TX 78234 USA. [Childs, John D.; Teyhen, Deydre S.; Benedict, Timothy M.; Morris, Jamie B.; Fortenberry, Andrew D.; McQueen, Rene M.; Preston, Janice B.; Wright, Alison C.; Dugan, Jessica L.] Baylor Univ, USA, Doctoral Program Phys Therapy MCCS HMT, Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Childs, John D.; Teyhen, Deydre S.; Benedict, Timothy M.; Morris, Jamie B.; Fortenberry, Andrew D.; McQueen, Rene M.; Preston, Janice B.; Wright, Alison C.; Dugan, Jessica L.] Baylor Univ, USA, Doctoral Program Phys Therapy MCCS HMT, Army Med Sch, Ft Sam Houston, TX 78234 USA. [George, Steven Z.] Univ Florida, Dept Phys Therapy, Brooks Ctr Rehabil Studies, Gainesville, FL USA. RP Childs, JD (reprint author), Baylor Univ, USA, Doctoral Program Phys Therapy MCCS HMT, Army Med Dept, 3151 Scott Rd,Rm 2307, Ft Sam Houston, TX 78234 USA. EM childsjd@gmail.com FU Department of Defense [PR054098] FX Congressionally Directed Peer Reviewed Medical Research Program (No. W81XWH-06-1-0564). The Prevention of Low Back Pain in the Military trial is supported by the peer-review medical research program of the Department of Defense (PR054098) NR 21 TC 16 Z9 16 U1 0 U2 12 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD NOV PY 2009 VL 41 IS 11 BP 2072 EP 2083 DI 10.1249/MSS.0b013e3181a84db2 PG 12 WC Sport Sciences SC Sport Sciences GA 512BX UT WOS:000271218700015 PM 19812508 ER PT J AU Afonso, DD Arslan, Z Bednar, AJ AF Afonso, Domingos D. Arslan, Zikri Bednar, Anthony J. TI Assessment of matrix-dependent analyte stability and volatility during open-vessel sample dissolution for arsenic, cadmium, mercury and selenium SO MICROCHIMICA ACTA LA English DT Article DE Arsenic; Cadmium; Mercury; Selenium; Volatility; Heating; Matrix effect; Open-vessel dissolution; ICP-MS ID ATOMIC-ABSORPTION-SPECTROMETRY; PLASMA-MASS SPECTROMETRY; CHEMICAL MODIFIERS; ENVIRONMENTAL-SAMPLES; MARINE PLANKTON; TRACE-ELEMENTS; SEA-WATER; ICP-MS; SPECTROSCOPY; DIGESTION AB The effects of calcium and magnesium (as nitrates) and phosphorous (as hydrogen phosphate) were investigated on the stability of As, Cd, Hg, and Se during open-vessel dissolution in Teflon vessels. Samples of mainly inorganic and biological matrices were dissolved in screw-capped Teflon tubes in HNO(3) only or in a mixture of HNO(3)-HF. The caps were then removed and the solutions were simultaneously evaporated at 120 A degrees C to near dryness without drying the contents (Method I) or to complete dryness with extended heating for 20 min at dryness (Method II). ICP-MS analysis indicated that the stabilities of Se and Hg were highly influenced by Ca, Mg and PO(4) content in the sample. Arsenic (As) and Cd did not show any significant instability or volatility. Selenium was lost in Method II from biological samples containing trace levels of Ca, Mg and PO(4). Mercury was unstable during heating in all samples, except bone ash for which no significant loss was detected in Method I. Losses observed for Hg and Se were consistent with Ca, Mg and PO(4) deficiency in the samples and hence indicated that nitrate and hydrogen phosphate salts of these matrix elements do improve stability of the relatively volatile elements during open-vessel dissolution in teflon vessels. While Se was effectively stabilized with sub-per cent levels of Ca, Mg and PO(4), Hg due its high volatility required significantly higher levels of Ca and PO(4) in the bone ash. C1 [Arslan, Zikri] Jackson State Univ, Dept Chem & Biochem, Jackson, MS 39217 USA. [Afonso, Domingos D.] Jackson State Univ, Environm Sci PhD Program, Jackson, MS 39217 USA. [Bednar, Anthony J.] USA, Waterways Expt Stn, ERDC, Vicksburg, MS 39180 USA. RP Arslan, Z (reprint author), Jackson State Univ, Dept Chem & Biochem, Jackson, MS 39217 USA. EM zikri.arslan@jsums.edu FU NIH-RCMI Program [G12RR013459]; NIH-ERDA Program [5 G11 HD046519-05] FX This work is funded in part by grants from NIH-RCMI Program (Grant No G12RR013459) and NIH-ERDA Program (Grant No 5 G11 HD046519-05) to Jackson State University. The views expressed herein are those of authors and do not necessarily represent the official views of the NIH and any of its sub-agencies. NR 26 TC 2 Z9 3 U1 0 U2 9 PU SPRINGER WIEN PI WIEN PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA SN 0026-3672 J9 MICROCHIM ACTA JI Microchim. Acta PD NOV PY 2009 VL 167 IS 1-2 BP 53 EP 59 DI 10.1007/s00604-009-0218-3 PG 7 WC Chemistry, Analytical SC Chemistry GA 513FK UT WOS:000271307700007 PM 20383291 ER PT J AU Wang, Y Pant, K Chen, ZJ Wang, GR Diffey, WF Ashley, P Sundaram, S AF Wang, Yi Pant, Kapil Chen, Zhijian Wang, Guiren Diffey, William F. Ashley, Paul Sundaram, Shivshankar TI Numerical analysis of electrokinetic transport in micro-nanofluidic interconnect preconcentrator in hydrodynamic flow SO MICROFLUIDICS AND NANOFLUIDICS LA English DT Article ID ENRICHMENT; CHANNELS; DEVICES; CHIP AB The phenomenon of enrichment of charged analytes due to the presence of an electric field barrier at the micro-nanofluidic interconnect can be harnessed to enhance sensitivity and limit-of-detection in sensor instruments. We present a numerical analysis framework to investigate two critical electrokinetic phenomena underlying the experimental observation in Plecis et al. (Micro Total Analysis Systems, pp 1038-1041, 2005b): (1) ion transport of background electrolytes (BGE) and (2) enrichment of analytes in the micro-nanofluidic devices that operate under hydrodynamic flow. The analysis is based on the full, coupled solution of the Poisson-Nernst-Planck (PNP) and Navi,r-Stokes equations, and the results are validated against analytical models of simple canonical geometry. Parametric simulation is performed to capture the critical effects of pressure head and BGE ion concentration on the electrokinetics and ion transport. Key findings obtained from the numerical analysis indicate that the hydrodynamic flow and overlapped electrical double layer induce concentration-polarization at the interfaces; significant electric field barrier arising from the Donnan potential forms at the micro-nano interfaces; and streaming potential and overall potential are effectively established across the micro-nanofluidic device. The simulation to examine analyte enrichment and its dependence on the hydrodynamic flow and analyte properties, demonstrates that order-of-magnitude enrichment can be achieved using properly configured hydrodynamic flow. The results can be used to guide practical design and operational protocol development of novel micro-nanofluidic interconnect-based analyte preconcentrators. C1 [Wang, Yi; Pant, Kapil; Chen, Zhijian; Sundaram, Shivshankar] CFD Res Corp, Huntsville, AL 35805 USA. [Wang, Guiren] Univ S Carolina, Dept Mech Engn, Columbia, SC 29208 USA. [Diffey, William F.; Ashley, Paul] USA, RDECOM, Redstone Arsenal, AL 35898 USA. RP Wang, Y (reprint author), CFD Res Corp, Huntsville, AL 35805 USA. EM yxw@cfdrc.com FU DARPA; US Army Aviation & Missile Command (US Army AMRDEC) [W31P4Q-07-C-0035] FX This research is sponsored by DARPA and US Army Aviation & Missile Command (US Army AMRDEC) under Grant number W31P4Q-07-C-0035. NR 25 TC 25 Z9 25 U1 1 U2 11 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1613-4982 J9 MICROFLUID NANOFLUID JI Microfluid. Nanofluid. PD NOV PY 2009 VL 7 IS 5 BP 683 EP 696 DI 10.1007/s10404-009-0428-3 PG 14 WC Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Fluids & Plasmas SC Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA 514TM UT WOS:000271418500007 ER PT J AU Robertson, JL Yun, HC Murray, CK AF Robertson, Janelle L. Yun, Heather C. Murray, Clinton K. TI Teaching of Interdisciplinary and Core Curriculum Topics Using Alternative Strategies SO MILITARY MEDICINE LA English DT Article ID ADULT FILM INDUSTRY; MEDICAL-ETHICS; LOS-ANGELES; INFECTIONS; EDUCATION; CLUSTER; DEBATE AB Objective: In the San Antonio Uniformed Services Health Education Consortium Infectious Diseases Fellowship program, didactic lecture formats were previously used to present training in interdisciplinary topics, journal discussions, and core curriculum topics, but herein is described the recent modification of the fellowship's teaching techniques along with a satisfaction survey. Methods: The initial modification to the curriculum included the institution of debates covering controversial core curriculum topics in parliamentary fashion. The second change was the teaching of interdisciplinary topics utilizing a conference moderator. To evaluate the impact of the new teaching strategies, an anonymous Likert-based survey was distributed to the staff and fellows. Results: The staff and fellows were uniformly satisfied with the changes in the curriculum and new strategies are preferred over the traditional teaching methods. Conclusions: Creating innovative forums to enhance the education of trainees has improved fellow and staff satisfaction with the teaching of these topics. C1 [Robertson, Janelle L.; Yun, Heather C.; Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv MCHE MDI 7E, Ft Sam Houston, TX 78234 USA. RP Robertson, JL (reprint author), Brooke Army Med Ctr, Infect Dis Serv MCHE MDI 7E, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 23 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2009 VL 174 IS 11 BP 1132 EP 1136 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 601LL UT WOS:000278060900002 PM 19960818 ER PT J AU Weld, KK Padden, D Ricciardi, R Bibb, SCG AF Weld, Konstantine Keian Padden, Diane Ricciardi, Richard Bibb, Sandra C. Garmon TI Health Literacy Rates in a Sample of Active Duty Military Personnel SO MILITARY MEDICINE LA English DT Article ID AFRICAN-AMERICAN; DISPARITIES; KNOWLEDGE; CANCER AB The results reported in this article are from a larger descriptive study examining the health literacy rates in active duty military personnel receiving health care within a culture of universal access. The purpose of this article is to describe the health literacy skills among a sample of active duty military personnel with comparison to the national population. Data were collected using the shortened version of the Test of Functional Health Literacy in Adults (S-TOFHLA) and the Rapid Estimate of Adult Literacy in Medicine (REALM) in a convenience sample of 155 active duty subjects at a major military hospital from January 2007 through May 2007. Results indicate that military personnel have adequate health literacy skills although variations were noted on the basis of health training and race/ethnicity. Although the S-TOFHLA was found to be a practical tool for assessing health literacy in a high-tempo health care setting, additional reliability and validity testing is needed. C1 [Weld, Konstantine Keian] Uniformed Serv Univ Hlth Sci, Grad Sch Nursing, US Publ Hlth Serv, Olney, MD 20852 USA. [Padden, Diane] Uniformed Serv Univ Hlth Sci, Dept Hlth Injury & Dis Management, Grad Sch Nursing, Bethesda, MD 20814 USA. [Ricciardi, Richard] Walter Reed Army Med Ctr, Nursing Res Serv, Walter Reed Stn, Washington, DC 20012 USA. [Bibb, Sandra C. Garmon] Uniformed Serv Univ Hlth Sci, Dept Hlth Syst Risk & Contingency Management, Grad Sch Nursing, Bethesda, MD 20814 USA. RP Weld, KK (reprint author), Uniformed Serv Univ Hlth Sci, Grad Sch Nursing, US Publ Hlth Serv, 17211 Palomino Ct, Olney, MD 20852 USA. FU USUHS, Graduate School of Nursing [T061IR-01] FX The article was completed in partial fulfillment of the requirements for the Doctor of Philosophy in Nursing Science degree at the University Services, University of the Health Sciences in Bethesda, Maryland. The work was funded by an intramural grant (T061IR-01) from USUHS, Graduate School of Nursing. NR 32 TC 2 Z9 2 U1 1 U2 5 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2009 VL 174 IS 11 BP 1137 EP 1143 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 601LL UT WOS:000278060900003 PM 19960819 ER PT J AU Rand, ER Lappan, CM Lee, JC Furgerson, JL AF Rand, Elden R. Lappan, Charles M. Lee, Joseph C. Furgerson, James L. TI Paging The Worldwide Cardiology Consultant: The Army Knowledge Online Telemedicine Consultation Program In Cardiology SO MILITARY MEDICINE LA English DT Article AB Background: Global operations place large numbers of military and nonmilitary personnel in austere environments. Aeromedical evacuation for cardiovascular issues is periodically required. The Army Knowledge Online (AKO) Telemedicine Consultation Program was initiated by the Office of the Surgeon General to electronically link deployed medical providers with subspecialty consultants to assist and guide triage and disposition. Methods: Electronic consultation triggered a text page to an on-call staff cardiologist at Brooke Army Medical Center. Cardiology teleconsultations for the first 3.5 years were analyzed. Results: Two hundred seven cardiology teleconsults were managed, with an average response time of 4 hours 54 minutes. The three most prevalent reasons for teleconsultation were electrocardiographic abnormalities, chest pain syndromes, and syncope. Six evacuations were avoided; 29 evacuations were facilitated. An estimated $144,000 was saved, plus intangible benefits. Conclusions: Cardiology teleconsultation provides a valuable service to deployed providers, decreases medical evacuation costs, and facilitates transfer of patients to appropriate facilities. C1 [Rand, Elden R.; Lappan, Charles M.; Furgerson, James L.] Brooke Army Med Ctr, Dept Med, Serv Cardiol, Ft Sam Houston, TX 78234 USA. [Lee, Joseph C.] Walter Reed Army Med Ctr, Dept Med, Serv Cardiol, Washington, DC 20307 USA. RP Rand, ER (reprint author), Brooke Army Med Ctr, Dept Med, Serv Cardiol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 8 TC 2 Z9 2 U1 1 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2009 VL 174 IS 11 BP 1144 EP 1148 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 601LL UT WOS:000278060900004 PM 19960820 ER PT J AU Glasser, JS Zacher, LL Thompson, JC Murray, CK AF Glasser, Jessie S. Zacher, Lisa L. Thompson, Jennifer C. Murray, Clinton K. TI Determination of the Internal Medicine Service's Role in Emergency Department Length of Stay at a Military Medical Center SO MILITARY MEDICINE LA English DT Article ID ACCESS; TIMES; CARE AB Objectives: Increasing numbers of emergency department (ED) visits and higher leaving-without-being-seen rates resulted in an evaluation of the contribution of the internal medicine service to the admission process. Methods: Standardized ED encounter sheets were completed by the medicine physician on duty (MOD) assessing various admission and consultative parameters. Results: 304 patient encounters revealed a 44-minute mean time from MOD consultation to order submission; 49% in under 30 minutes and 76% in under an hour. There was no difference in time among MOD shifts, staff and residents, or admission diagnoses. Reasons for delays were receiving multiple consults at a time (36%) and needing further specialty consultation or additional workup (30%). Conclusions: Most medicine admissions took less than an hour from time of MOD consultation to time orders were written. Areas of improvement include expediting discussion with specialists and timely but appropriate ED workup before consultation. C1 [Glasser, Jessie S.; Zacher, Lisa L.; Thompson, Jennifer C.; Murray, Clinton K.] Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. RP Glasser, JS (reprint author), Brooke Army Med Ctr, Dept Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 9 TC 1 Z9 1 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2009 VL 174 IS 11 BP 1163 EP 1166 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 601LL UT WOS:000278060900007 PM 19960823 ER PT J AU Hartstein, BH Boor, DD Nystuen, CM AF Hartstein, Bonnie H. Boor, Diane D. Nystuen, Christopher M. TI Comparison of Medical Visits by Active Duty and National Guard Soldiers at a Forward Deployed Medical Facility in Iraq SO MILITARY MEDICINE LA English DT Article ID PHYSICAL READINESS; ARMY RESERVISTS AB Study objective: To compare differences in disease nonbattle injury data between cohorts of deployed active duty (AD) and National Guard (NO) soldiers. Methods: This study compared AD and NG soldiers presenting for medical visits to a level I clinic in Iraq. Retrospective data were collected from the Department of Defense (DOD) electronic records system, on soldiers in two AD and two NO companies with populations of 391 and 425, respectively, regarding number of visits, age, gender, diagnosis, and evacuation for laboratory tests or X-rays (level II care) or for hospitalization or subspecialty services (level III care). Visits occurred during the 11-month period of October 1, 2006 through August 30, 2007. Results: In the AD group, 180 of 391(46%) soldiers presented for 594 visits (1.5 visits per soldier). In the NG units, 300 of 425 (71%) soldiers made 1,294 visits (3.1 visits per soldier). There were 67 AD evacuations, 54 sent for level II care and 13 for level III care as compared to 151 NO evacuations, 116 to level II and 35 to level III. The leading diagnoses for visits in both groups were musculoskeletal and dermatologic and the leading cause for evacuation was genitourinary. Gender utilization rates were 3.4 and 7.4 visits per AD and NO female compared to 1.2 and 2.8 visit per group matched male. Conclusion: NO soldiers presented for care and required evacuation twice as frequently as AD soldiers. NO patients were typically older. Female soldiers in both groups had higher utilization and evacuation rates than males. C1 [Hartstein, Bonnie H.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Boor, Diane D.] Thomas Moore Hlth Clin, Ft Hood, TX 76544 USA. [Nystuen, Christopher M.] Grafenwoehr Med Clin, APO, AE 09114 USA. RP Hartstein, BH (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 6 TC 2 Z9 2 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2009 VL 174 IS 11 BP 1167 EP 1171 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 601LL UT WOS:000278060900008 PM 19960824 ER PT J AU Nielsen, PE Murphy, CS Schulz, J Deering, SH Truong, V McCartin, T Clemons, JL AF Nielsen, Peter E. Murphy, Christopher S. Schulz, Jodi Deering, Shad H. Truong, Vu McCartin, Tamarin Clemons, Jeffrey L. TI Female Soldiers' Gynecologic Healthcare in Operation Iraqi Freedom: A Survey of Camps With Echelon Three Facilities SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Annual Meeting of the Armed Forces District of the American-College-of-Obstetricians-and-Gynecologists CY OCT 28-31, 2006 CL Sonthofen, GERMANY SP Amer Coll Obstet & Gynecol, Armed Forces Dist ID DEPLOYMENT; WOMEN AB Objective: To describe female soldiers' predeployment gynecologic healthcare screening, common symptoms, and availability of gynecologic care during Operation Iraqi Freedom. Methods: A questionnaire distributed to U.S. military females presenting to outpatient facilities in level 3 echelon of care between August 2005 and March 2006. Results: Three-hundred ninety seven of 401 surveys (99%) were returned. Ten percent of deployed females (40) had no cervical cytology screening 1 year before deployment and 27% of the 399 required additional treatments for abnormal cervical cytology during deployment. Thirty-five percent reported a gynecologic problem and 44% received care at their base. Irregular bleeding was the most common gynecologic problem. Forty-four percent of women used some form of hormonal contraception; however, 43% changed methods because of unavailability. One-third of soldiers received predeployment menses regulation counseling, with 48% of those using continuous oral contraceptive pills for cycle control. Conclusion: Gaps remain in predeployment gynecologic screening and counseling. These critical predeployment medical evaluations must remain a priority for all female soldiers to ensure unit readiness. C1 [Nielsen, Peter E.; Deering, Shad H.; Clemons, Jeffrey L.] Madigan Army Med Ctr, Dept Obstet & Gynecol, Tacoma, WA 98431 USA. [Murphy, Christopher S.] Gen Leonard Wood Army Community Hosp, Obstet & Gynecol Serv, Xiamen 361005, Peoples R China. [Truong, Vu] Womack Army Med Ctr, Dept Obstet & Gynecol, Ft Bragg, NC 28310 USA. [Schulz, Jodi] Albert Lea Med Ctr, Dept Obstet & Gynecol, Albert Lea, MN 56007 USA. [McCartin, Tamarin] US Army Hlth Clin Vicenza, Obstet & Gynecol Serv, I-36100 Vicenza, Italy. RP Nielsen, PE (reprint author), Madigan Army Med Ctr, Dept Obstet & Gynecol, 9040 Fitzsimmons, Tacoma, WA 98431 USA. NR 9 TC 18 Z9 18 U1 0 U2 8 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2009 VL 174 IS 11 BP 1172 EP 1176 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 601LL UT WOS:000278060900009 PM 19960825 ER PT J AU Sill, JM Morris, MJ Johnson, JE Allan, PF Grbach, VX AF Sill, Joshua M. Morris, Michael J. Johnson, James E. Allan, Patrick F. Grbach, Vincent X. TI Cardiopulmonary Exercise Test Interpretation Using Age-Matched Controls to Evaluate Exertional Dyspnea SO MILITARY MEDICINE LA English DT Article ID NORMAL VALUES; CAPACITY; ADULTS AB Background: Cardiopulmonary exercise testing (CPET) is one method to diagnose unexplained dyspnea in young adults, yet few normal reference values exist in this population. This study evaluated interpretation of maximal CPET in a young adult cohort with known pulmonary disorders using published reference values compared to age-matched normal controls. Methods: A control population of 69 healthy military volunteers with normal chest radiographs, pulmonary function testing, and bronchoprovocation testing were compared to 105 patients with exertional dyspnea. Both groups underwent a standardized evaluation including CPET on a graded exercise treadmill to maximal exercise with expired gas analysis. Results: Measurements from CPET in the dyspnea group were interpreted using published reference values compared to control population results (mean +/- 1.65 x SD). Statistical comparison of predicted normals (reference vs. control) of maximal oxygen consumption (>83% vs. 82%), ventilatory anaerobic threshold (>40% vs. 53%), respiratory rate (<60 vs. 56 breaths/min), tidal volume to inspiratory capacity (<80% vs. 111%), ventilatory equivalent for carbon dioxide production (<40 vs. 38), and maximal voluntary ventilation minus minute ventilation (>11 vs. -1 L/min) was performed. The overall specificity for tidal volume to inspiratory capacity improved using age-matched controls but sensitivity was decreased. Other parameters were not significantly different. Conclusions: The use of age-matched controls for CPET results in an increase in specificity and decrease in sensitivity for respiratory limitations to exercise, when compared to reference values. The study findings suggest that CPET may be insensitive in detecting mild disease in young healthy adults. C1 [Sill, Joshua M.; Morris, Michael J.] Brooke Army Med Ctr, Pulm Dis Crit Care Med Serv, Dept Med, Ft Sam Houston, TX 78234 USA. [Johnson, James E.] Univ Alabama Birmingham, Birmingham, AL 35233 USA. [Allan, Patrick F.] Landstuhl Reg Med Ctr, Pulm Dis Crit Care Serv, APO, AE 09180 USA. [Grbach, Vincent X.] Tripler Army Med Ctr, Dept Med, Pulm Dis Crit Care Serv, Honolulu, HI 96859 USA. RP Sill, JM (reprint author), Brooke Army Med Ctr, Pulm Dis Crit Care Med Serv, Dept Med, 3851 Roger Brooke Rd, Ft Sam Houston, TX 78234 USA. NR 22 TC 4 Z9 4 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD NOV PY 2009 VL 174 IS 11 BP 1177 EP 1182 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 601LL UT WOS:000278060900010 PM 19960826 ER PT J AU Harrison, MF Neary, JP Albert, WJ Kuruganti, U Croll, JC Chancey, VC Bumgardner, BA AF Harrison, Michael F. Neary, J. Patrick Albert, Wayne J. Kuruganti, Usha Croll, James C. Chancey, V. Carol Bumgardner, Bradley A. TI Measuring Neuromuscular Fatigue in Cervical Spinal Musculature of Military Helicopter Aircrew SO MILITARY MEDICINE LA English DT Article ID TRAPEZIUS MUSCLE METABOLISM; CHRONIC NECK PAIN; PILOTS; STRENGTH; ELECTROMYOGRAPHY; RESPONSES AB Neck pain and muscle function in aircrew have received considerable attention. We hypothesized normalized electromyography (EMG) frequency would provide insight into appropriate methods to assess muscle fatigue in helicopter aircrew. Methods: 40 helicopter aircrew performed isometric testing that included maximal voluntary contractions (MVC) and 70% MVC endurance protocols of extension, flexion, and left and right lateral flexion for cervical muscles. Bilateral muscle activity in the splenius capitis, sternocleidomastoid, and upper trapezius was monitored with EMG. Normalized mean EMG frequency was calculated for each muscle at the start and end of the 70% MVC trials to determine which muscles fatigued and limited force maintenance during each isometric movement. Results: For extension, the left and right splenius capitis fatigued by similar to 21-22% (p<0.01); for flexion, the left and right sternocleidomastoid fatigued by similar to 11-14% (p<0.01); for right flexion, the right sternocleidomastoid fatigued by similar to 15% (p<0.01); for left flexion, the left sperms capitis and left sternocleidomastoid fatigued by similar to 7.2% (p = 0.02) and similar to 11.2% (p = 0.03), respectively; in no trials did the trapezius muscles display fatigue as measured by EMG. Conclusion: The smaller agonist muscles were the most susceptible to fatigue during submaxiinal isometric endurance movements in the cervical muscles of helicopter aircrew. C1 [Harrison, Michael F.; Neary, J. Patrick] Univ Regina, Fac Kinesiol & Hlth Studies, Regina, SK S4S 0A2, Canada. [Albert, Wayne J.; Kuruganti, Usha; Croll, James C.] Univ New Brunswick, Fac Kinesiol, Fredericton, NB E3B 5A3, Canada. [Chancey, V. Carol; Bumgardner, Bradley A.] USA, Aeromed Res Lab, Ft Rucker, AL 36362 USA. RP Harrison, MF (reprint author), Univ Regina, Fac Kinesiol & Hlth Studies, 3737 Wascana Pkwy, Regina, SK S4S 0A2, Canada. RI Albert, Wayne/G-2203-2012 FU Department of National Defense Canada [W3931-050513-001-SV] FX The authors thank all members of Canadian Forces 1 Wing Tactical Helicopter Squadrons, Dr. Yves Losier and Greg Dickinson for their assistance with this project. This project would not have been possible without the ground-breaking genius of Dr. Nabeh Alem (deceased). Funding support provided by Department of National Defense Canada (Military Health Program no. W3931-050513-001-SV). NR 28 TC 15 Z9 17 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2009 VL 174 IS 11 BP 1183 EP 1189 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 601LL UT WOS:000278060900011 PM 19960827 ER PT J AU Kaushik, S Tharion, WJ AF Kaushik, Sangeeta Tharion, William J. TI Graphical User Interface for a Remote Medical Monitoring System: US Army Medic Recommendations SO MILITARY MEDICINE LA English DT Article ID DISPLAY; CHILDREN; CARE AB We obtained recommendations for a graphical user interface (GUI) design for a new medical monitoring system. Data were obtained from 26 combat-experienced medics. Volunteers were briefed on the medical monitoring system. They then completed a questionnaire on background medical treatment experience, provided drawings on how and what information should be displayed on the GUI screens for use on a personal digital assistant, and participated in focus group sessions with four to seven medics per group to obtain group consensus on what information the GUI screens should contain. Detailed displays on seven screens provide the medical and situational awareness information medics need for triage decisions and for early processing of a casualty. The created GUI screens are a combination of object-based and text-based information using a color-coded system. Medics believed the information displayed with these GUI designs would improve treatment of casualties on the battlefield. C1 [Kaushik, Sangeeta; Tharion, William J.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Kaushik, Sangeeta] Washington Hosp Ctr, Dept Emergency Med, Washington, DC 20010 USA. RP Kaushik, S (reprint author), USA, Environm Med Res Inst, Bldg 42,Kansas St, Natick, MA 01760 USA. FU U.S. Army Medical and Materiel Command, Fort Detrick, MD FX The authors thank Karen Speckman for help with data collection, Julio Gonzalez for graphics support, and Dr. Reed Hoyt for providing scientific guidance during the manuscript preparation. We are also very grateful to all the experienced medics who provided the information needed for this report. This study was funded by the U.S. Army Medical and Materiel Command, Fort Detrick, MD under the Army Technology Objective program entitled: Warfighter Physiological Status Monitoring-Initial Capability. NR 21 TC 0 Z9 0 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2009 VL 174 IS 11 BP 1190 EP 1195 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 601LL UT WOS:000278060900012 PM 19960828 ER PT J AU Washington, M Brown, M Palys, T Tyner, S Bowden, R AF Washington, Michael Brown, Matthew Palys, Thomas Tyner, Stuart Bowden, Robert TI Clinical Microbiology During the Vietnam War SO MILITARY MEDICINE LA English DT Article AB During the period of 1965-1968, over two dozen Army microbiologists were deployed to various locations in Southeast Asia in support of the Vietnam War. Their role was to serve both a clinical laboratory mission/function at the mobile Army surgical hospital and mobile laboratory level as well as to perform research roles in all of the facilities. They were essential to the formulation of medical intelligence as well as to the practice of operational medicine in the deployed environment. The results of their laboratory investigations provided commanders and military physicians with critical medical information for patient care, outbreak investigation, and forensic analysis. As with many soldiers in support of the infantry and armor combat forces, most of the work occurs behind the scenes and their contributions are often left out of the historical literature. This article presents a brief overview of microbiology performed by Army microbiologists during the Vietnam War. C1 [Washington, Michael] USUHS, Silver Spring, MD 20910 USA. [Brown, Matthew] USAMEDDAC Korea, Unit 15244, APO, AP 96205 USA. [Palys, Thomas] Landstuhl Reg Med Ctr, APO, AE 09180 USA. [Tyner, Stuart] USAMC AFRIMS, APO, AP 96546 USA. [Bowden, Robert] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Washington, M (reprint author), USUHS, 4301 Jones Bridge Rd,Bldg B,Room 3097, Silver Spring, MD 20910 USA. NR 29 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2009 VL 174 IS 11 BP 1209 EP 1214 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 601LL UT WOS:000278060900015 PM 19960831 ER PT J AU Tatari-Calderone, Z Minniti, CP Kratovil, T Stojakovic, M Vollmer, A Barjaktarevic, I Zhang, E Hoang, A Luban, NLC Vukmanovic, S AF Tatari-Calderone, Zohreh Minniti, Caterina P. Kratovil, Tonya Stojakovic, Milica Vollmer, Alison Barjaktarevic, Igor Zhang, Ed Hoang, Albert Luban, Naomi L. C. Vukmanovic, Stanislav TI rs660 polymorphism in Ro52 (SSA1; TRIM 21) is a marker for age-dependent tolerance induction and efficiency of alloimmunization in sickle cell disease SO MOLECULAR IMMUNOLOGY LA English DT Review DE Sickle cell disease; Red blood cell transfusion; Antibodies; Gene polymorphisms ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; ANTINUCLEAR ANTIBODIES; CLINICAL-SIGNIFICANCE; AUTOANTIGEN RO52; PROTEIN; TRANSFUSION; CHILDREN; SEQUENCE; GENOME; LIGASE AB Patients with sickle cell disease (SCD) who receive red blood cell (RBC) transfusions have a higher rate of anti-RBC (allo and auto) antibody development than other transfused subjects. We hypothesized that an incidence and/or kinetics of RBC-specific antibody formation in SCD patients is influenced by a linked inheritance of the hemoglobin beta S (Hb beta S) allele and a polymorphism rs660C/T in the neighboring Ro52 gene. We found that 75% of C/T heterozygous and only 30.8% of T/T homozygous patients that developed antibodies were first transfused before the age of five. In addition, there was a significant inverse correlation between time of exposure to antigen or number of transfusions received and the age when T/T patients received first transfusion, indicating progressive development of competence of their immune system. In contrast, this correlation was not observed in patients with C/T genotype. Finally, increased expression of Ro52 was associated with the presence of the T/T genotype. These results suggest that rs660 polymorphism is a marker of efficiency of tolerance induction in early childhood and immune competence development to RBC antigens in SCD patients of pre-teen/teen age. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Tatari-Calderone, Zohreh; Stojakovic, Milica; Vollmer, Alison; Barjaktarevic, Igor; Vukmanovic, Stanislav] Childrens Natl Med Ctr, Ctr Canc & Immunol Res, Childrens Res Inst, Washington, DC 20010 USA. [Tatari-Calderone, Zohreh; Minniti, Caterina P.; Luban, Naomi L. C.; Vukmanovic, Stanislav] George Washington Univ, Sch Med, Dept Pediat, Washington, DC 20052 USA. [Minniti, Caterina P.; Kratovil, Tonya; Luban, Naomi L. C.] Childrens Natl Med Ctr, Div Hematol & Oncol, Washington, DC 20010 USA. [Kratovil, Tonya] Uniformed Serv Univ Hlth Sci, Washington, DC USA. [Kratovil, Tonya] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Zhang, Ed; Hoang, Albert] Childrens Natl Med Ctr, Biostat & Informat Unit, Childrens Res Inst, Washington, DC 20010 USA. [Luban, Naomi L. C.] Childrens Natl Med Ctr, Div Lab Med & Pathol, Washington, DC 20010 USA. RP Vukmanovic, S (reprint author), Childrens Natl Med Ctr, Ctr Canc & Immunol Res, Childrens Res Inst, 111 Michigan Ave NW, Washington, DC 20010 USA. EM svukmano@cnmc.org NR 31 TC 28 Z9 28 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0161-5890 J9 MOL IMMUNOL JI Mol. Immunol. PD NOV PY 2009 VL 47 IS 1 BP 64 EP 70 DI 10.1016/j.molimm.2008.12.027 PG 7 WC Biochemistry & Molecular Biology; Immunology SC Biochemistry & Molecular Biology; Immunology GA 527KO UT WOS:000272366200011 PM 19201475 ER PT J AU Gimble, JM Bray, MS Young, A AF Gimble, J. M. Bray, M. S. Young, A. TI Circadian biology and sleep: missing links in obesity and metabolism? SO OBESITY REVIEWS LA English DT Editorial Material DE circadian; diabetes; obesity; sleep ID NIGHT-EATING SYNDROME; PAS KINASE; GENE-EXPRESSION; POTENTIAL ROLE; CLOCK; RHYTHMS; MICE; DEADENYLASE; NOCTURNIN; WOMEN AB P>This supplement highlights key talks presented at the Pennington Symposium. The collected papers provide a state of the art review of circadian biology at the basic and clinical levels in the context of nutrition, obesity and sleep medicine. Investigators from multiple disciplines attempted to translate new information concerning molecular mechanisms into practical clinical applications, as well as foster new research hypotheses and directions to this exciting field of science and medicine. Furthermore, we hope to spark the interest and attention of the next generation of scientists who will tackle the questions presented by the changing interface between technology, lifestyle and biological rhythms. C1 [Gimble, J. M.] Pennington Biomed Res Ctr, Stem Cell Biol Lab, Baton Rouge, LA 70808 USA. [Bray, M. S.] Baylor Coll Med, Houston, TX 77030 USA. [Young, A.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. RP Gimble, JM (reprint author), Pennington Biomed Res Ctr, Stem Cell Biol Lab, 6400 Perkins Rd, Baton Rouge, LA 70808 USA. EM gimblejm@pbrc.edu NR 31 TC 10 Z9 11 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1467-7881 EI 1467-789X J9 OBES REV JI Obes. Rev. PD NOV PY 2009 VL 10 SU 2 BP 1 EP 5 PG 5 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 509VE UT WOS:000271046100001 PM 19849796 ER PT J AU Maurer, T Wilson, DL Smith, SR Deaver, DM Flug, EA Nguyen, OT AF Maurer, Tana Wilson, David L. Smith, Stevie R. Deaver, Dawne M. Flug, Eric A. Nguyen, Oanh Tho TI Search and detection comparing midwave and longwave infrared SO OPTICAL ENGINEERING LA English DT Article DE search; detection; sensor modeling; midwave infrared; longwave infrared AB To investigate the benefits of multiband infrared sensor design for target detection, search and detection experiments were conducted in the midwave infrared (MWIR) and longwave infrared (LWIR) wavebands in both rural and urban battlefields. In each battlefield environment, real imagery was collected in both bands by a single sensor using the same optics for both bands, resulting in perfect co-registration of the imagery. In order to study the performance impact of the spectral content, and not diffraction or other sensor-specific differences, the images were processed as needed so that differences in resolution due to diffraction were mitigated. The results of perception experiments, including detection probabilities, search times, and false alarm data, were compared between the wavebands. (C) 2009 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3264148] C1 [Maurer, Tana; Wilson, David L.; Smith, Stevie R.; Deaver, Dawne M.; Flug, Eric A.; Nguyen, Oanh Tho] USA, Res Dev & Engn Command, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Maurer, T (reprint author), USA, Res Dev & Engn Command, Night Vis & Elect Sensors Directorate, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. NR 14 TC 5 Z9 5 U1 1 U2 3 PU SPIE-SOC PHOTOPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD NOV PY 2009 VL 48 IS 11 AR 116401 DI 10.1117/1.3264148 PG 9 WC Optics SC Optics GA 538UW UT WOS:000273210600021 ER PT J AU Kindsvatter, PS AF Kindsvatter, Peter S. TI Grunts: The American Combat Soldier in Vietnam SO PACIFIC HISTORICAL REVIEW LA English DT Book Review C1 [Kindsvatter, Peter S.] USA, Ordnance Ctr & Sch, Washington, DC 20310 USA. RP Kindsvatter, PS (reprint author), USA, Ordnance Ctr & Sch, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV CALIFORNIA PRESS PI BERKELEY PA C/O JOURNALS DIVISION, 2000 CENTER ST, STE 303, BERKELEY, CA 94704-1223 USA SN 0030-8684 J9 PAC HIST REV JI Pac. Hist. Rev. PD NOV PY 2009 VL 78 IS 4 BP 655 EP U17 PG 3 WC History SC History GA 511TL UT WOS:000271191500025 ER PT J AU Buckenmaier, CC Rupprecht, C McKnight, G McMillan, B White, RL Gallagher, RM Polomano, R AF Buckenmaier, Chester C., III Rupprecht, Christine McKnight, Geselle McMillan, Brian White, Ronald L. Gallagher, Rollin M. Polomano, Rosemary TI Pain Following Battlefield Injury and Evacuation: A Survey of 110 Casualties from the Wars in Iraq and Afghanistan SO PAIN MEDICINE LA English DT Article DE Combat Casualty Care; Pain; Continuous Peripheral Nerve Block; Pain Outcomes ID MANAGEMENT; ANESTHESIA; CARE; SOLDIERS; FREEDOM; ANXIETY; PREVENTION; OPERATIONS; MECHANISMS AB Objective. Advances in regional anesthesia, specifically continuous peripheral nerve blocks (CPNBs), have greatly improved pain outcomes for wounded soldiers in Iraq and Afghanistan. Pain management practice variations, however, do exist, depending on the availability of pain-trained military professionals deployed to combat support hospitals. An exploratory study was undertaken to examine pain and other outcomes during evacuation and at Landstuhl Regional Medical Center (LRMC), Germany. Design. A mixed-methods, semistructured interview survey design was conducted on a convenience sample of wounded U. S. soldiers evacuated from Iraq and Afghanistan to LRMC. Setting and Patients. A total of 110 wounded soldiers evacuated from Iraq and Afghanistan from July 2007 to February 2008 completed a pain survey at LRMC. Data were collected on demographics, injury mechanism, last 24-hour average, least, and worst, and pain now by using a 0-10 scale, and percent pain relief (from 0% [No relief] to 100% [Complete relief]). Similar items and measures of anxiety, distress, and worry during flight transport were measured (from 0 [None] to 10 [Extreme]). Responses were analyzed by using descriptive and correlational statistics, multiple linear regression, Mann-Whitney U-tests, and t-tests. The Walter Reed Army Medical Center, Human Use Committee approved this investigation. Results. Participants were typically male (99.1%), Caucasian (80%), and injured from improvised explosive devices (60%) and gunshots (21.8%). Average and worst pain scores were inversely correlated with pain relief during transport (r = -0.58 and r = -0.46, respectively; P < 0.001), and low to moderately positively correlated with increased anxiety, distress, and worry during transport (P < 0.05). Average percent pain relief achieved was 45.2% +/- 26.6% during transport and 64.5% +/- 23.5% while at LRMC (P < 0.001). Participants with CPNB catheters placed at LRMC reported significantly less pain right now (P = 0.031) and better pain relief (P = 0.029) than soldiers without CPNBs. Conclusions. Our findings underscore the value of early aggressive pain management after major combat injuries. Increased pain was associated with increased anxiety, distress, and worry during transport, suggesting the need for psychological management along with analgesia. Regional anesthesia techniques while at LRMC contributed to better pain outcomes. C1 [Buckenmaier, Chester C., III; Rupprecht, Christine; McKnight, Geselle; McMillan, Brian] Walter Reed Army Med Ctr, Army Reg Anesthesia & Pain Management Initiat, Washington, DC 20307 USA. [Buckenmaier, Chester C., III; White, Ronald L.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [McMillan, Brian] Womack Army Med Ctr, Ft Bragg, NC USA. [White, Ronald L.] Landstuhl Reg Med Ctr, Landstuhl, Germany. [Gallagher, Rollin M.; Polomano, Rosemary] Univ Penn, Philadelphia, PA 19104 USA. RP Buckenmaier, CC (reprint author), Walter Reed Army Med Ctr, Army Reg Anesthesia & Pain Management Initiat, Bldg 2,Ward 44,Room 4418,6900 Georgia Ave,NW, Washington, DC 20307 USA. EM baybuck@gmail.com; polomanr@nursing.upenn.edu FU John P. Murtha Neuroscience & Pain Institute and Departmental FX Financial Support: John P. Murtha Neuroscience & Pain Institute and Departmental NR 30 TC 32 Z9 33 U1 0 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1526-2375 J9 PAIN MED JI Pain Med. PD NOV-DEC PY 2009 VL 10 IS 8 BP 1487 EP 1496 DI 10.1111/j.1526-4637.2009.00731.x PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA V20FE UT WOS:000208125100020 PM 19843233 ER PT J AU Campos, NA Chiles, JH Plunkett, AR AF Campos, Napolean A. Chiles, John H. Plunkett, Anthony R. TI Ultrasound-Guided Cryoablation of Genitofemoral Nerve for Chronic Inguinal Pain SO PAIN PHYSICIAN LA English DT Article DE Chronic pain; ultrasound; cryoablation; pain management; neuropathic pain; nerve block ID CHRONIC PELVIC PAIN; GUIDANCE IMPROVES; GROIN HERNIA; BLOCK; NEURALGIA; QUALITY; SUCCESS; REPAIR AB Background: Cryotechnology is a modality of renewed interest in pain management. It is safe and effective when used to treat neuropathies of sensory and mixed nerves. Cryoablation, in general, is devoid of the risk of neuroma formation and can provide several weeks to months of adequate pain relief. Traditionally, cryoablation was applied blindly to the target area. The use of ultrasound guidance may improve the efficacy and reduce morbidity. We report a case of a successful cryoablation of the femoral component of the genitofemoral nerve using ultrasound guidance in a patient with chronic inguinal pain. A 47 year-old male (ASA Classification 11 for obesity, HLD, and OSA, 125kg, 69 in) presented to the Walter Reed Pain Clinic with the complaint of 4/10 VAS left sided groin pain of 3 month duration. The patient was diagnosed with a neuropathy of the femoral component of the left genitofemoral nerve. He received a diagnostic block with local anesthetic and reported immediate pain relief that lasted one week. The patient was counseled on the risks and benefits of cryoablation. The skin was anesthetized with 1% lidocaine and a 14 gauge angiocatheter needle was introduced using an in-plane technique to the target area. A Westco Cryoablation machine (San Diego, California) with a 14 gauge Lloyd Neurostat cryoprobe was then passed via the angiocatheter. The area was treated for two 3-minute intervals while the cryo probe was visualized under ultrasound. Ultrasound is increasingly utilized for both acute and chronic pain procedures. Ultrasound offered several advantages in this case. it allowed a smaller gauge introducer and cryoablation probe to be used since there was better visualization of the target area. Ultrasound helped identify important vascular structures, allowing safe introduction of the introducer and cryoablation probe. The patient remains pain free at 2-month follow-up. C1 [Campos, Napolean A.; Chiles, John H.; Plunkett, Anthony R.] Walter Reed Army Med Ctr, Washington, DC 20009 USA. RP Plunkett, AR (reprint author), Walter Reed Army Med Ctr, 6800 Georgia Ave NW, Washington, DC 20009 USA. EM anthonyplunkett@comcast.net NR 25 TC 23 Z9 23 U1 0 U2 3 PU AM SOC INTERVENTIONAL PAIN PHYSICIANS PI PADUCAH PA 81 LAKEVIEW DR, PADUCAH, KY 42001 USA SN 1533-3159 J9 PAIN PHYSICIAN JI Pain Physician PD NOV-DEC PY 2009 VL 12 IS 6 BP 997 EP 1000 PG 4 WC Anesthesiology; Clinical Neurology SC Anesthesiology; Neurosciences & Neurology GA 537EQ UT WOS:000273096200008 PM 19935984 ER PT J AU Shear, DA Williams, AJ Sharrow, K Lu, XCM Tortella, FC AF Shear, Deborah A. Williams, Anthony J. Sharrow, Keith Lu, Xi-Chun M. Tortella, Frank C. TI Neuroprotective profile of dextromethorphan in an experimental model of penetrating ballistic-like brain injury SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR LA English DT Article DE Penetrating ballistic-like brain injury; PBBI; Traumatic brain injury; TBI; Dextromethorphan; DM; Motor; Cognitive; Novel object recognition; NOR ID D-ASPARTATE ANTAGONIST; PREFRONTAL CORTEX; MEDIATED NEUROPROTECTION; CORTICAL-NEURONS; SIGMA-RECEPTORS; RAT MODEL; CALCIUM; DEXTRORPHAN; ATTENTION; ISCHEMIA AB Dextromethorphan (DM) has been well-characterized as a neuroprotective agent in experimental models of CNS injury. The goal of this study was to determine the neuroprotective profile of DM in a military-relevant model of penetrating ballistic-like brain injury (PBBI). In an acute (3 day) dose-response study, anesthetized male Sprague-Dawley rats were exposed to a unilateral frontal PBBI with DM (0.156-10 mg/kg) or vehicle delivered as an i.v. bolus from 30 min to 48 h post-injury. In a follow-up (7 day) experiment, the 10-mg/kg bolus injections of DM were administered in conjunction with a 6-h infusion (5 mg/kg/h). DM bolus injections alone produced a dose-dependent improvement in motor recovery on a balance beam task at 3 days post-injury. However, more rapid recovery (24 h) was observed on this task when the bolus injections were combined with the 6-h infusion. Moreover, the DM bolus/infusion treatment regimen resulted in a significant (76%) improvement in cognitive performance in a novel object recognition (NOR) task at 7 days post-injury. Although post-injury administration of DM (all doses) failed to reduce core lesion size, the maximum dose of DM (10 mg/kg) was effective in reducing silver-stained axonal fiber degeneration in the cortical regions adjacent to the injury. Published by Elsevier Inc. C1 [Shear, Deborah A.; Williams, Anthony J.; Sharrow, Keith; Lu, Xi-Chun M.; Tortella, Frank C.] Walter Reed Army Inst Res, Dept Appl Neurobiol, Silver Spring, MD 21045 USA. RP Shear, DA (reprint author), Walter Reed Army Inst Res, MRMC UWI C,Bldg 503-2W14, Silver Spring, MD 20910 USA. EM Deborah.Shear@AMEDD.ARMY.MIL RI Shear, Deborah/B-3607-2011 NR 33 TC 15 Z9 15 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0091-3057 J9 PHARMACOL BIOCHEM BE JI Pharmacol. Biochem. Behav. PD NOV PY 2009 VL 94 IS 1 BP 56 EP 62 DI 10.1016/j.pbb.2009.07.006 PG 7 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA 513ZH UT WOS:000271362300009 PM 19619574 ER PT J AU Sharlow, ER Close, D Shun, TY Leimgruber, S Reed, R Mustata, G Wipf, P Johnson, J O'Neil, M Grogl, M Magill, AJ Lazo, JS AF Sharlow, Elizabeth R. Close, David Shun, Tongying Leimgruber, Stephanie Reed, Robyn Mustata, Gabriela Wipf, Peter Johnson, Jacob O'Neil, Michael Groegl, Max Magill, Alan J. Lazo, John S. TI Identification of Potent Chemotypes Targeting Leishmania major Using a High-Throughput, Low-Stringency, Computationally Enhanced, Small Molecule Screen SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Editorial Material ID NEGLECTED TROPICAL DISEASES; CUTANEOUS-LEISHMANIASIS; VISCERAL LEISHMANIASIS; HUMAN MACROPHAGES; AMPHOTERICIN-B; ASSAYS; AMASTIGOTES; DONOVANI; DRUGS; CHEMOTHERAPY AB Patients with clinical manifestations of leishmaniasis, including cutaneous leishmaniasis, have limited treatment options, and existing therapies frequently have significant untoward liabilities. Rapid expansion in the diversity of available cutaneous leishmanicidal chemotypes is the initial step in finding alternative efficacious treatments. To this end, we combined a low-stringency Leishmania major promastigote growth inhibition assay with a structural computational filtering algorithm. After a rigorous assay validation process, we interrogated similar to 200,000 unique compounds for L. major promastigote growth inhibition. Using iterative computational filtering of the compounds exhibiting > 50% inhibition, we identified 553 structural clusters and 640 compound singletons. Secondary confirmation assays yielded 93 compounds with EC(50)s <= 1 mu M, with none of the identified chemotypes being structurally similar to known leishmanicidals and most having favorable in silico predicted bioavailability characteristics. The leishmanicidal activity of a representative subset of 15 chemotypes was confirmed in two independent assay formats, and L. major parasite specificity was demonstrated by assaying against a panel of human cell lines. Thirteen chemotypes inhibited the growth of a L. major axenic amastigote-like population. Murine in vivo efficacy studies using one of the new chemotypes document inhibition of footpad lesion development. These results authenticate that low stringency, large-scale compound screening combined with computational structure filtering can rapidly expand the chemotypes targeting in vitro and in vivo Leishmania growth and viability. C1 [Sharlow, Elizabeth R.; Close, David; Shun, Tongying; Leimgruber, Stephanie; Reed, Robyn; Wipf, Peter; Lazo, John S.] Univ Pittsburgh, Drug Discovery Inst, Pittsburgh, PA 15260 USA. [Sharlow, Elizabeth R.; Close, David; Shun, Tongying; Leimgruber, Stephanie; Reed, Robyn; Wipf, Peter; Lazo, John S.] Pittsburgh Mol Lib Screening Ctr, Pittsburgh, PA USA. [Sharlow, Elizabeth R.; Lazo, John S.] Univ Pittsburgh, Dept Pharmacol, Pittsburgh, PA 15261 USA. [Sharlow, Elizabeth R.; Lazo, John S.] Univ Pittsburgh, Dept Biol Chem, Pittsburgh, PA 15261 USA. [Mustata, Gabriela] Univ Pittsburgh, Dept Computat Biol, Pittsburgh, PA USA. [Wipf, Peter] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA. [Johnson, Jacob; O'Neil, Michael; Groegl, Max; Magill, Alan J.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Sharlow, ER (reprint author), Univ Pittsburgh, Drug Discovery Inst, Pittsburgh, PA 15260 USA. EM lazo@pitt.edu RI Mustata, Gabriela/A-6515-2011; Reed, Robyn/P-4381-2014 OI Reed, Robyn/0000-0003-2141-0490 FU NIMH NIH HHS [U54MH074411, U54 MH074411] NR 77 TC 34 Z9 34 U1 0 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD NOV PY 2009 VL 3 IS 11 AR e540 DI 10.1371/journal.pntd.0000540 PG 11 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 522XG UT WOS:000272032900003 PM 19888337 ER PT J AU Pelaez, JC Fernandez, EB Larrondo-Petrie, MM AF Pelaez, Juan C. Fernandez, Eduardo B. Larrondo-Petrie, Maria M. TI Misuse patterns in VoIP SO SECURITY AND COMMUNICATION NETWORKS LA English DT Article DE security; forensics; patterns; VoIP; network attacks AB To protect against security attacks, it is necessary to be aware of typical risks and to have a good understanding of how vulnerabilities can be exploited. Security patterns are useful to guide the security design of systems by providing generic solutions that can stop a variety of attacks, but it is not clear to an inexperienced designer what pattern should be applied to stop a specific attack. Additionally, security patterns are not useful for network forensics purposes because they do not emphasize the modus operandi of the attack. As a complement and improvement, we have proposed a new type of pattern, the misuse pattern. This pattern describes, from the point of view of the attacker, how a type of information misuse is performed, analyzes the ways of stopping the attack, and considers how to trace the attack once it has happened. To apply this approach, we need a catalog of misuse patterns. In this paper, we restrict our interest to voice over Internet protocol (VoIP) and we present a set of typical and frequent misuse patterns for VoIP: denial of service (DoS), call interception, theft of service, and call hijacking on VoIP. These patterns could be the start of a comprehensive catalog that would be of practical value to developers, testers, users, and researchers. Published in 2009 by John Wiley & Sons, Ltd. C1 [Pelaez, Juan C.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Fernandez, Eduardo B.; Larrondo-Petrie, Maria M.] Florida Atlantic Univ, Dept Comp Sci & Engn, Boca Raton, FL 33433 USA. RP Pelaez, JC (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM juan.c.pelaez@arl.army.mil NR 37 TC 6 Z9 6 U1 1 U2 3 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 1939-0114 J9 SECUR COMMUN NETW JI Secur. Commun. Netw. PD NOV-DEC PY 2009 VL 2 IS 6 BP 635 EP 653 DI 10.1002/sec.105 PG 19 WC Computer Science, Information Systems; Telecommunications SC Computer Science; Telecommunications GA 554NP UT WOS:000274442000013 ER PT J AU Maddox, WT Glass, BD Wolosin, SM Savarie, ZR Bowen, C Matthews, MD Schnyer, DM AF Maddox, W. Todd Glass, Brian D. Wolosin, Sasha M. Savarie, Zachary R. Bowen, Christopher Matthews, Michael D. Schnyer, David M. TI The Effects of Sleep Deprivation on Information-Integration Categorization Performance SO SLEEP LA English DT Article DE Category learning; procedural learning; striatum; sleep consolidation; sleep deprivation ID MULTIPLE MEMORY-SYSTEMS; TASK INTERFERENCE; CATEGORY; FEEDBACK; FATIGUE; BRAIN; MODELS; ROLES AB Background: Sleep deprivation is a serious problem facing individuals in many critical societal roles. One of the most ubiquitous tasks facing individuals is categorization. Sleep deprivation is known to affect rule-based categorization in the classic Wisconsin Card Sorting Task, but, to date, information-integration categorization has not been examined. Study Objectives: To investigate the effects of sleep deprivation on information-integration category learning. Design: Participants performed an information-integration categorization task twice, separated by a 24-hour period, with or without sleep between testing sessions. Participants: Twenty-one West Point cadets participated in the sleep-de privation group and 28 West Point cadets participated in a control group. Measurements and Results: Sleep deprivation led to an overall performance deficit during the second testing session-that is, whereas participants allowed to sleep showed a significant performance increase during the second testing session, Sleepless participants showed a small (but nonsignificant) performance decline during the second testing session. Model-based analyses indicated that a major contributor to the sleep-deprivation effect was the poor second-session performance of a subgroup of sleep-deprived participants who shifted from optimal information-integration strategies at the end of the first session to less-optimal rule-based strategies at the start of the second session. Sleep-deprived participants who used information-integration strategies in both sessions showed no drop in performance in the second session, mirroring the behavior of control participants. Conclusions: The findings suggest that the neural systems underlying information-integration strategies are not strongly affected by sleep deprivation but, rather, that the use of an information-integration strategy in a task may require active inhibition of rule-based strategies, with this inhibitory process being vulnerable to the effects of sleep deprivation. C1 [Maddox, W. Todd; Glass, Brian D.; Wolosin, Sasha M.; Schnyer, David M.] Univ Texas Austin, Dept Psychol, Austin, TX 78712 USA. [Maddox, W. Todd; Schnyer, David M.] Univ Texas Austin, Inst Neurosci, Austin, TX 78712 USA. [Savarie, Zachary R.; Bowen, Christopher; Matthews, Michael D.] US Mil Acad, West Point, NY 10996 USA. RP Maddox, WT (reprint author), Univ Texas Austin, Dept Psychol, 1 Univ Stn A8000, Austin, TX 78712 USA. EM maddox@psy.utexas.edu FU Center for Strategic and Innovative Technologies at The University of Texas at Austin [W911NF-072-0023] FX This research was supported by Army grant #W911NF-072-0023, through The Center for Strategic and Innovative Technologies at The University of Texas at Austin. We thank Victoria Williams and Dasa Zeithamova for help with data collection.; Financial Support: This research was supported by Army grant #W911NF-07-2-0023, through The Center for Strategic and Innovative Technologies at The University of Texas at Austin. NR 37 TC 15 Z9 15 U1 1 U2 3 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PD NOV 1 PY 2009 VL 32 IS 11 BP 1439 EP 1448 PG 10 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 518LM UT WOS:000271693700007 PM 19928383 ER PT J AU Gulia, J Kim, P Kortepeter, MG Nguewou, A Waga, M Lai, L AF Gulia, Jyoti Kim, Peter Kortepeter, Mark G. Nguewou, Annick Waga, Masashi Lai, Leon TI MULTIPLE FRACTURES OF THE SYMPHYSIS PUBIS DUE TO TUBERCULOUS OSTEOMYELITIS SO SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH LA English DT Article C1 [Gulia, Jyoti; Kim, Peter; Nguewou, Annick; Lai, Leon] Washington Hosp Ctr, Dept Med, Washington, DC 20010 USA. [Waga, Masashi] Washington Hosp Ctr, Dept Pathol, Microbiol Sect, Washington, DC 20010 USA. [Kortepeter, Mark G.] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. RP Gulia, J (reprint author), Washington Hosp Ctr, Dept Med, 110 Irving St NW, Washington, DC 20010 USA. EM guliajyoti@gmail.com NR 17 TC 2 Z9 2 U1 0 U2 1 PU SOUTHEAST ASIAN MINISTERS EDUC ORGANIZATION PI BANGKOK PA SEAMEO-TROPMED, 420-6 RAJVITHI RD,, BANGKOK 10400, THAILAND SN 0125-1562 J9 SE ASIAN J TROP MED JI Southeast Asian J. Trop. Med. Public Health PD NOV PY 2009 VL 40 IS 6 BP 1279 EP 1283 PG 5 WC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine SC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine GA 530GV UT WOS:000272578200016 PM 20578462 ER PT J AU Crisp, HC Stewart, IJ Blatz, PJ Rice, DH Okulicz, JF AF Crisp, Howard C. Stewart, Ian J. Blatz, Peter J. Rice, David H. Okulicz, Jason F. TI Successful Treatment of Severe Pneumocystis Pneumonia with Clindamycin-Primaquine in an HIV-Negative Patient SO SOUTHERN MEDICAL JOURNAL LA English DT Article DE clindamycin; HIV-negative; Pneumocystis jiroveci; Pneumocystitis pneumonia; primaquine ID ACQUIRED-IMMUNODEFICIENCY-SYNDROME; CARINII-PNEUMONIA; JIROVECII PNEUMONIA; THERAPY; MANAGEMENT; INFECTION; AIDS AB Pneumocystis pneumonia is an increasingly recognized threat in non-HIV immunosuppressed patients and is associated with worse outcomes compared to HIV-infected patients. The preferred first line treatment is trimethoprim-sulfamethoxazole; however, second line treatments for those intolerant of this regimen have been primarily studied in patients with acquired immunodeficiency syndrome (AIDS). We report a case of Pneumocystis pneumonia in a 75-year-old man with chronic lymphocytic leukemia (CLL) and a history of sulfa allergy successfully treated with clindamycin-primaquine. C1 Wilford Hall USAF Med Ctr, Dept Internal Med, Lackland AFB, TX 78236 USA. Wilford Hall USAF Med Ctr, Dept Infect Dis, Lackland AFB, TX 78236 USA. Wilford Hall USAF Med Ctr, Dept Pulm & Crit Care, Lackland AFB, TX 78236 USA. RP Okulicz, JF (reprint author), Brooke Army Med Ctr, Infect Dis Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM jason.okulicz@amedd.army.mil NR 13 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 J9 SOUTH MED J JI South.Med.J. PD NOV PY 2009 VL 102 IS 11 BP 1161 EP 1163 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 519HB UT WOS:000271754600015 PM 19864989 ER PT J AU Brown, RS Carlson, TJ Welch, AE Stephenson, JR Abernethy, CS Ebberts, BD Langeslay, MJ Ahmann, ML Feil, DH Skalski, JR Townsend, RL AF Brown, Richard S. Carlson, Thomas J. Welch, Abigail E. Stephenson, John R. Abernethy, C. Scott Ebberts, Blaine D. Langeslay, Mike J. Ahmann, Martin L. Feil, Dan H. Skalski, John R. Townsend, Richard L. TI Assessment of Barotrauma from Rapid Decompression of Depth-Acclimated Juvenile Chinook Salmon Bearing Radiotelemetry Transmitters SO TRANSACTIONS OF THE AMERICAN FISHERIES SOCIETY LA English DT Article ID SURVIVAL; BUOYANCY; BEHAVIOR; FISH AB This study investigated the mortality of and injury to juvenile Chinook salmon Oncorhynchus tshawytscha exposed to simulated pressure changes associated with passage through a large Kaplan hydropower turbine. Mortality and injury varied depending on whether a fish was carrying a transmitter, the method of transmitter implantation, the depth of acclimation, and the size of the fish. Juvenile Chinook salmon implanted with radio transmitters were more likely than those without to die or sustain injuries during simulated turbine passage. Gastric transmitter implantation resulted in higher rates of injury and mortality than surgical implantation. Mortality and injury increased with increasing pressure of acclimation. Injuries were more common in subyearling fish than in yearling fish. Gas emboli in the gills and internal hemorrhaging were the major causes of mortality. Rupture of the swim bladder and emphysema in the fins were also common. This research makes clear that the exposure of juvenile Chinook salmon bearing radiotelemetry transmitters to simulated turbine pressures with a nadir of 8-19 kPa can result in barotrauma, leading to immediate or delayed mortality. The study also identified sublethal barotrauma injuries that may increase susceptibility to predation. These findings have significant implications for many studies that use telemetry devices to estimate the survival and behavior of juvenile salmon as they pass through large Kaplan turbines typical of those within the Columbia River hydropower system. Our results indicate that estimates of turbine passage survival for juvenile Chinook salmon obtained with radiotelemetry devices may be negatively biased. C1 [Brown, Richard S.; Carlson, Thomas J.; Welch, Abigail E.; Stephenson, John R.; Abernethy, C. Scott] Pacific NW Natl Lab, Richland, WA 99352 USA. [Ebberts, Blaine D.; Langeslay, Mike J.] USA, Corps Engineers, Portland, OR 97208 USA. [Ahmann, Martin L.; Feil, Dan H.] USA, Corps Engineers, Walla Walla, WA 99362 USA. [Skalski, John R.; Townsend, Richard L.] Univ Washington, Sch Aquat & Fishery Sci, Columbia Basin Res, Seattle, WA 98101 USA. RP Brown, RS (reprint author), Pacific NW Natl Lab, POB 999, Richland, WA 99352 USA. EM rich.brown@pnl.gov OI Skalski, John/0000-0002-7070-2505 FU U.S. Army Corps of Engineers, Portland District; U.S. Department of Energy [DE-AC05-76RL01830] FX Funding was provided by the U.S. Army Corps of Engineers, Portland District. The authors acknowledge the support and oversight of the U.S. Army Corps of Engineers Turbine Survival Technical Team. We thank Brad Eby and Bobby Johnson of the U. S. Army Corps of Engineers at McNary Dam. We also acknowledge the help of staff from the U. S. Geological Survey who implanted the salmon with transmitters, especially Russell Perry. Rosanna Tudor and other personnel from the Washington Department of Fish and Wildlife assisted with capture of fish. We appreciate the assistance of Andrea Currie, Joanne Duncan, Ben Tice, Allison Hedges, Jennifer Panther, Katie Murray, Ian Welch, Jake Tucker, Evan Arntzen, Gayle Dirkes, Bob Mueller, Marie-Helene Theriault, Craig McKinstry, and Ralph Elston. The Pacific Northwest National Laboratory animal facilities used in this research are AAALAC-certified; fish were handled in accordance with federal guidelines for the care and use of laboratory animals, and protocols for our study were approved by the Institutional Animal Care and Use Committee at Battelle-Pacific Northwest Division. The Pacific Northwest National Laboratory is operated by Battelle for the U.S. Department of Energy under Contract DE-AC05-76RL01830. NR 29 TC 31 Z9 32 U1 1 U2 9 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0002-8487 EI 1548-8659 J9 T AM FISH SOC JI Trans. Am. Fish. Soc. PD NOV PY 2009 VL 138 IS 6 BP 1285 EP 1301 DI 10.1577/T08-122.1 PG 17 WC Fisheries SC Fisheries GA 589DC UT WOS:000277124500008 ER PT J AU Jindal, RM Neff, RT Abbott, KC Hurst, FP Elster, EA Falta, EM Patel, P Cukor, D AF Jindal, R. M. Neff, R. T. Abbott, K. C. Hurst, F. P. Elster, E. A. Falta, E. M. Patel, P. Cukor, D. TI Association Between Depression and Nonadherence in Recipients of Kidney Transplants: Analysis of the United States Renal Data System SO TRANSPLANTATION PROCEEDINGS LA English DT Article ID IMMUNOSUPPRESSIVE MEDICATION; ADHERENCE; RACE AB Introduction. In our previous prospective single-center study, using validated self-administered instruments, we demonstrated correlation between depression and nonadherence in recipients of kidney transplants. The purpose of this study was to confirm our finding that depression was associated with nonadherence in a large database of transplant recipients for which we used the United States Renal Data System (USRDS). Methods. We conducted a retrospective cohort study of 32,757 Medicare primary renal transplant recipients in the USRDS who underwent transplantation from January 1, 2000 to July 31, 2004 and were followed up through December 31, 2004, assessing Medicare claims showing depression and nonadherence based on codes of the International Classification of Diseases, 9th Revision. Results. Logistic regression analysis (adjusted hazards ratio 1.69 with 95% confidence interval, 1.48-1.92) and log rank test (P < .0005) showed that there was a strong association of depression and nonadherence. Depression was associated with nonadherence, irrespective of the time of depression, whether it was pretransplantation (P < .001) or posttransplantation (P < .001). Nonadherence was also associated with black race (P < .001), younger age (P < .001), less HLA mismatch (P < .005), recipients of living kidneys and patients who underwent transplantation a longer time ago (P < .001). Furthermore, patients with 12 or less years of education were more nonadherent (P < .001). Among the transplant donor factors we investigated, donor black race (P < .001) and expanded criteria donor kidneys were strongly associated with nonadherence (P < .001). However, donor age and delayed graft function were not significantly associated with nonadherence. Conclusions. Future clinical trials of immunosuppressive therapy should assess the impact of depression on graft survival. C1 [Jindal, R. M.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. Brookdale Univ Hosp, Brooklyn, NY USA. Med Ctr, Brooklyn, NY USA. George Washington Univ, Washington, DC USA. RP Jindal, RM (reprint author), Walter Reed Army Med Ctr, Dept Surg, Georgia Ave, Washington, DC 20307 USA. EM jindalr@msn.com OI Abbott, Kevin/0000-0003-2111-7112 NR 17 TC 20 Z9 20 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0041-1345 J9 TRANSPL P JI Transplant. Proc. PD NOV PY 2009 VL 41 IS 9 BP 3662 EP 3666 DI 10.1016/j.transproceed.2009.06.187 PG 5 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA 524DL UT WOS:000272123900025 PM 19917363 ER PT J AU Brown, JA Riddle, MS Putnam, SD Schlett, CD Armstrong, AW Jones, JJ Tribble, DR Sanders, JW AF Brown, Jamey A. Riddle, Mark S. Putnam, Shannon D. Schlett, Carey D. Armstrong, Adam W. Jones, James J. Tribble, David R. Sanders, John W. TI Outcomes of diarrhea management in operations Iraqi Freedom and Enduring Freedom SO TRAVEL MEDICINE AND INFECTIOUS DISEASE LA English DT Article DE Travelers' diarrhea; Empiric therapy; US military; Middle East AB Introduction: Among deployed U.S. military personnel, a sub-population of international travelers, acute infectious diarrhea continues to be a leading cause of morbidity and a potential threat to military effectiveness. Methods: To assess outcomes and satisfaction of diarrhea management in the field, a systematic survey was given to military personnel during mid- or post-deployment from Iraq or Afghanistan, from January through August 2004. Results: Sixty-three percent of those surveyed reported at least one episode of diarrhea, while less than half sought care for their symptoms. Overall, trends of decreased post-treatment duration were noted as traveler's diarrhea therapy modalities grew more complex, controlling for severity of illness at presentation. Among those reporting diarrhea, the greatest level of satisfaction was seen in treatment with IV fluids (59%) followed by antibiotics (46%) and loperamide (40%). The greatest amount of dissatisfaction was seen in treatments with oral fluids only. Conclusion: While current standard of care is self-treatment of diarrhea in civilian travelers, the U.S. military lacks standards outlining self-treatment of personnel at the individual level. Further research is needed to develop treatment guidelines on diarrhea management during military deployment. Published by Elsevier Ltd. C1 [Riddle, Mark S.] USN, Med Res Ctr, Enter Dis Dept, Silver Spring, MD 20910 USA. [Brown, Jamey A.] Womack Army Med Ctr, Ft Bragg, NC USA. [Putnam, Shannon D.] USN, Med Res Unit 2, Jakarta, Indonesia. [Schlett, Carey D.; Armstrong, Adam W.] USN, Med Res Unit 3, Cairo, Egypt. [Jones, James J.] Army Cent Command, Troop Med Clin, Doha, Qatar. [Tribble, David R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Sanders, John W.] Naval Med Res Ctr Detachment, Lima, Peru. RP Riddle, MS (reprint author), USN, Med Res Ctr, Enter Dis Dept, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM mark.riddle@med.navy.mil RI Riddle, Mark/A-8029-2011 NR 25 TC 8 Z9 8 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1477-8939 J9 TRAVEL MED INFECT DI JI Travel Med. Infect. Dis. PD NOV PY 2009 VL 7 IS 6 BP 337 EP 343 DI 10.1016/j.tmaid.2009.09.001 PG 7 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA V17IV UT WOS:000207931800002 PM 19945010 ER PT J AU House, BL Hollingdale, MR Sacci, JB Richiel, TL AF House, Brent L. Hollingdale, Michael R. Sacci, John B., Jr. Richiel, Thomas L. TI Functional immunoassays using an in-vitro malaria liver-stage infection model: where do we go from here? SO TRENDS IN PARASITOLOGY LA English DT Review ID PLASMODIUM-FALCIPARUM MALARIA; HEPATOMA-CELL LINE; NATURALLY ACQUIRED ANTIBODIES; SPOROZOITE SURFACE PROTEIN-2; CD8(+) T-CELLS; CIRCUMSPOROZOITE-PROTEIN; CULTURED-CELLS; EXOERYTHROCYTIC STAGE; PROTECTIVE ANTIBODIES; BERGHEI SPOROZOITES AB For more than 25 years, the ISI assay and ILSDA have been used to study the development of the malaria parasite in the liver, to discover and characterize sporozoite and liver-stage antigens, to support the development of malaria vaccine candidates, and to search for immunological correlates of protection in animals and in humans. Although both assays have been limited by low sporozoite invasion rates, significant biological variability, and the subjective nature of manually counting hepatocytes containing parasites as the read-out, they have nevertheless been useful tools for exploring parasite biology. This review describes the origin, application and current status of these assays, critically discusses the need for improvements, and explores the roles of these assays in supporting the development of an effective vaccine against Plasmodium falciparum malaria. C1 [House, Brent L.; Hollingdale, Michael R.; Richiel, Thomas L.] USN, Med Res Ctr, Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD 21737 USA. [Sacci, John B., Jr.] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA. RP Richiel, TL (reprint author), USN, Med Res Ctr, Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD 21737 USA. EM thomas.richie@med.navy.mil RI Richie, Thomas/A-8028-2011; OI Richie, Thomas/0000-0002-2946-5456 FU US Army Medical Research & Material Command FX Because of restrictions in the number of references permitted, not all relevant citations have been included. All protocols reported herein involving human subjects that were conducted by the Naval Medical Research Center were reviewed and approved by the Institutional Review Board of the Naval Medical Research Center in accordance with the US Navy regulations (SECNAVINST 3900.39B) governing the use of human subjects in medical research. The opinions and assertions herein are those of the authors and are not to be construed as official or as reflecting the views of the US Navy or the Department of Defense. This work was supported by funds allocated to the Naval Medical Research Center by the US Army Medical Research & Material Command. NR 87 TC 6 Z9 6 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1471-4922 J9 TRENDS PARASITOL JI Trends Parasitol. PD NOV PY 2009 VL 25 IS 11 BP 525 EP 533 DI 10.1016/j.pt.2009.08.004 PG 9 WC Parasitology SC Parasitology GA 521LW UT WOS:000271923900008 PM 19747878 ER PT J AU Rafuse, ES AF Rafuse, Ethan S. TI 'To Check . . . the Very Worst and Meanest of Our Passions': Common Sense, 'Cobbon Sense', and the Socialization of Cadets at Antebellum West Point SO WAR IN HISTORY LA English DT Article DE American Civil War; antebellum United States; common sense; education; history; Mahan; military; moral philosophy; philosophy; Thayer; United States Army; United States Military Academy; Wayland; West Point; Whig AB This essay adds to a growing body of scholarship that challenges the image of the United States Military Academy at West Point and US Army officer corps as institutions that were isolated in the nineteenth century from developments in civilian society. It does so by calling attention to parallels between the ideas that shaped the antebellum military academy's approach to cadet education and socialization and those of the Scottish-American 'common sense' school of moral philosophy that was popular among members of America's emerging middle class before the Civil War. It describes these parallels, how they reflected a common cultural milieu that shaped the outlook of the common sense philosophers, their adherents and education theorists in antebellum America, and the authorities at West Point, and identifies traits that distinguished how many West Point graduates conducted themselves during the American Civil War that are suggestive of these parallels. C1 [Rafuse, Ethan S.] US Army Command, Ft Leavenworth, KS 66027 USA. [Rafuse, Ethan S.] Gen Staff Coll, Ft Leavenworth, KS USA. RP Rafuse, ES (reprint author), US Army Command, Ft Leavenworth, KS 66027 USA. NR 80 TC 1 Z9 1 U1 0 U2 1 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0968-3445 J9 WAR HIST JI War Hist. PD NOV PY 2009 VL 16 IS 4 BP 406 EP 424 DI 10.1177/09683445081341683 PG 19 WC History; International Relations SC History; International Relations GA 494GH UT WOS:000269799300002 ER PT J AU Swayampakula, K Boddu, VM Nadavala, SK Abburi, K AF Swayampakula, Kalyani Boddu, Veera M. Nadavala, Siva Kumar Abburi, Krishnaiah TI Competitive adsorption of Cu (II), Co (II) and Ni (II) from their binary and tertiary aqueous solutions using chitosan-coated perlite beads as biosorbent SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE Biosorption; Chitosan; Perlite; Copper; Nickel; Cobalt bisolute and tertiary solutions ID BAGASSE FLY-ASH; SUGAR-INDUSTRY WASTE; BIOMASS OEDOGONIUM SP; HEAVY-METAL; AMINATED CHITOSAN; CO(II) IONS; RED MUD; REMOVAL; BIOSORPTION; WATER AB A new composite chitosan-coated biosorbent was prepared and was used for the removal and recovery of heavy metals from aqueous solution. In the present investigation, equilibrium adsorption characteristics of Cu (II), Ni (II),and Co (II) from their binary and tertiary solution on newly developed biosorbent chitosan-coated perlite beads were evaluated through batch and column studies. These beads were characterized by using FTIR, EDXRF and surface area analysis techniques. The effect of various biosorption parameters like effect of pH. agitation time. concentration of adsorbate and amount of adsorbent on extent of adsorption was investigated. The adsorption follows Lagergren first order kinetic model. The equilibrium adsorption data were fitted to Freundlich and Langmuir adsorption isotherm models and the model parameters were evaluated. Both the models represent the experimental data satisfactorily. The sorbent loaded with metal was regenerated with 0.1 N NaOH solution. Furthermore the column dynamic studies indicate the re-usage of the biosorbent. (C) 2009 Published by Elsevier B.V. C1 [Swayampakula, Kalyani; Nadavala, Siva Kumar; Abburi, Krishnaiah] Sri Venkateswara Univ, Dept Chem, Biopolymers & Thermophys Labs, Tirupati 517502, Andhra Pradesh, India. [Boddu, Veera M.] USA, Engn Res & Dev Ctr ERDC, Construct Engn Res Labs, Environm Proc Branch CN E, Champaign, IL 61826 USA. RP Abburi, K (reprint author), Sri Venkateswara Univ, Dept Chem, Biopolymers & Thermophys Labs, Tirupati 517502, Andhra Pradesh, India. EM abburikrishnaiah@gmail.com RI Dr., Nadavala Siva Kumar /D-5404-2011; swayampakula, kalyani/D-6233-2011 OI Dr., Nadavala Siva Kumar /0000-0003-3210-8254; FU Council of Scientific and Industrial Research (CSIR), New Delhi FX One of the authors S. Kalyani is thankful to the Council of Scientific and Industrial Research (CSIR), New Delhi. for granting SRF. Gratitude is expressed to Prof. G. Rama Krishna Naidu, Dept. of Environmental Science, S.V. University, Tirupati, India and Prof. Satish Kayasth, Analytical Chemistry Division, Baba Atomic Research Center (BARC), Mumbai, India for their excellent laboratory assistance and for providing instrumental facilities. NR 47 TC 72 Z9 74 U1 4 U2 47 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD OCT 30 PY 2009 VL 170 IS 2-3 BP 680 EP 689 DI 10.1016/j.jhazmat.2009.05.106 PG 10 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 500NV UT WOS:000270310500022 PM 19553014 ER PT J AU Furtado, MD Zheng, A Sedigh-Sarvestani, M Lumley, L Lichtenstein, S Yourick, D AF Furtado, Marcio de Araujo Zheng, Andy Sedigh-Sarvestani, Madineh Lumley, Lucille Lichtenstein, Spencer Yourick, Debra TI Analyzing large data sets acquired through telemetry from rats exposed to organophosphorous compounds: An EEG study SO JOURNAL OF NEUROSCIENCE METHODS LA English DT Article DE Status epilepticus; Neuropathology; Organophosphorous; EEG; Algorithm ID ORGANIZING NEURAL-NETWORK; SEIZURE DETECTION; EPILEPTIC SEIZURES; TIME-FREQUENCY; BRAIN-DAMAGE; SCALP EEG; SOMAN; NEUROPATHOLOGY; RECORDINGS; INJURY AB The organophosphorous compound soman is an acetylcholinesterase inhibitor that causes damage to the brain. Exposure to soman causes neuropathology as a result of prolonged and recurrent seizures. in the present study, long-term recordings of cortical EEG were used to develop an unbiased means to quantify measures of seizure activity in a large data set while excluding other signal types. Rats were implanted with telemetry transmitters and exposed to soman followed by treatment with therapeutics similar to those administered in the field after nerve agent exposure. EEG, activity and temperature were recorded continuously for a minimum of 2 days pre-exposure and 15 days post-exposure. A set of automatic MATLAB algorithms have been developed to remove artifacts and measure the characteristics of long-term EEG recordings. The algorithms use short-time Fourier transforms to compute the power spectrum of the signal for 2-s intervals. The spectrum is then divided into the delta, theta, alpha, and beta frequency bands. A linear fit to the power spectrum is used to distinguish normal EEG activity from artifacts and high amplitude spike wave activity. Changes in time spent in seizure over a prolonged period are a powerful indicator of the effects of novel therapeutics against seizures. A graphical user interface has been created that simultaneously plots the raw EEG in the time domain, the power spectrum, and the wavelet transform. Motor activity and temperature are associated with EEG changes. The accuracy of this algorithm is also verified against visual inspection of video recordings up to 3 days after exposure. (C) 2009 Published by Elsevier B.V. C1 [Yourick, Debra] Walter Reed Army Inst Res, Off Sci Director, Silver Spring, MD 20910 USA. [Lumley, Lucille] USA, Med Res Inst Chem Def, Washington, DC USA. RP Yourick, D (reprint author), Walter Reed Army Inst Res, Off Sci Director, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Debra.Yourick@us.army.mil RI Yourick, Debra/A-2121-2011 FU Defense Threat Reduction Agency; National Research Council FX The Defense Threat Reduction Agency and the National Research Council have provided financial and/or programmatic support. The technical assistance of Benjamin Robertson (MATLAB programming), Michael Addis, Kristin Clements, Seth Fairfax, Benjamin Litwack, Jamie Waterhouse, Christopher Robison, Theresa Ward, Joshua Kraft, Sarah Parylak and Stephen Estes is gratefully acknowledged. NR 45 TC 8 Z9 8 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-0270 EI 1872-678X J9 J NEUROSCI METH JI J. Neurosci. Methods PD OCT 30 PY 2009 VL 184 IS 1 BP 176 EP 183 DI 10.1016/j.jneumeth.2009.07.020 PG 8 WC Biochemical Research Methods; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA 509XU UT WOS:000271053400024 PM 19632275 ER PT J AU Yuan, W Tang, F Li, HF Parker, T LiCausi, N Lu, TM Bhat, I Wang, GC Lee, S AF Yuan, W. Tang, F. Li, H. -F. Parker, T. LiCausi, N. Lu, T. -M. Bhat, I. Wang, G. -C. Lee, S. TI Biaxial CdTe/CaF2 films growth on amorphous surface SO THIN SOLID FILMS LA English DT Article DE Cadmium telluride; Surface morphology; Interfaces; Heterostructures; Reflection high-energy electron diffraction; Transmission electron microscopy; Metal organic chemical vapor deposition ID CDTE THIN-FILM; DETECTOR MATERIAL; RECENT PROGRESS; SOLAR-CELLS; SI FILMS; EPITAXY; SILICON; POLYCRYSTALLINE; HETEROEPITAXY; TELLURIDE AB A continuous and highly biaxially textured CdTe film was grown by metal organic chemical vapor deposition on an amorphous substrate using biaxial CaF2 nanorods as a buffer layer. The interface between the CdTe film and CaF2 nanorods and the morphology of the CdTe film were studied by transmission electron microscopy (TEM) and scanning electron microscopy. Both the TEM and X-ray pole figure analysis clearly reveal that the crystalline orientation of the continuous CdTe film followed the {111}< 121 > biaxial texture of the CaF2 nanorods. A high density of twin faults was observed in the CdTe film. Furthermore, the near surface texture of the CdTe thin film was investigated by reflection high-energy electron diffraction (RHEED) and RHEED surface pole figure analysis. Twinning was also observed from the RHEED surface pole figure analysis. (C) 2009 Elsevier B.V. All rights reserved. C1 [Yuan, W.; Tang, F.; Li, H. -F.; Parker, T.; Lu, T. -M.; Wang, G. -C.] Rensselaer Polytech Inst, Dept Phys Appl Phys & Astron, Troy, NY 12180 USA. [LiCausi, N.; Bhat, I.] Rensselaer Polytech Inst, Dept Elect Comp & Syst Engn, Troy, NY 12180 USA. [Lee, S.] USA, Armament Res Dev & Engn Ctr, Benet Labs, Watervliet, NY 12189 USA. RP Yuan, W (reprint author), Rensselaer Polytech Inst, Dept Phys Appl Phys & Astron, 110 8th St, Troy, NY 12180 USA. EM yuanw@rpi.edu FU NSF [0506738]; Department of Education GAANN fellowship FX This work is supported in part by NSF no. 0506738. TP is supported by the Department of Education GAANN fellowship. We would like to thank Dr. Churamani Gaire for the stimulating discussions. NR 28 TC 12 Z9 12 U1 0 U2 3 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0040-6090 J9 THIN SOLID FILMS JI Thin Solid Films PD OCT 30 PY 2009 VL 517 IS 24 BP 6623 EP 6628 DI 10.1016/j.tsf.2009.04.052 PG 6 WC Materials Science, Multidisciplinary; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA 501VI UT WOS:000270410800027 ER PT J AU Matyas, GR Wieczorek, L Beck, Z Ochsenbauer-Jambor, C Kappes, JC Michael, NL Polonis, VR Alving, CR AF Matyas, Gary R. Wieczorek, Lindsay Beck, Zoltan Ochsenbauer-Jambor, Christina Kappes, John C. Michael, Nelson L. Polonis, Victoria R. Alving, Carl R. TI Neutralizing antibodies induced by liposomal HIV-1 glycoprotein 41 peptide simultaneously bind to both the 2F5 or 4E10 epitope and lipid epitopes SO AIDS LA English DT Article DE 2F5; 4E10; adjuvants; glycoprotein 41; lipid A; lipid antigens; membrane proximal external region; peptide antigens ID HUMAN-IMMUNODEFICIENCY-VIRUS; PROXIMAL EXTERNAL REGION; MONOCLONAL-ANTIBODIES; TYPE-1 ENVELOPE; VACCINE DESIGN; MEMBRANE; GP41; ADJUVANTS; PROTEIN; AUTOREACTIVITY AB Objectives: There is a need to develop HIV-1 vaccine formulations that incorporate inexpensive antigens and clinically acceptable potent adjuvants for inducing neutralizing antibodies. The purpose of this initial vaccine study was to produce peptide- and lipid-induced murine mAbs that replicate the characteristics of the 2175 and/or 4E10 human antibodies in binding both to the membrane proximal external region (MPER) of glycoprotein 41 and the adjacent lipid bilayer for neutralizing HIV-1 infection of CD4(+) lymphocytes. Research designs and methods: Liposomes containing a synthetic MPER peptide as a peptide antigen, phosphatidylinositol-4-phosphate (PIP) as a lipid antigen, and monophosphoryl lipid A as a potent adjuvant were used as a formulation to immunize mice. mAbs were then produced and tested for binding to MPER, glycoprotein 41, and PIP and for the ability to neutralize HIV-1 infection of CD4+ cells in a human peripheral blood mononuclear cell assay. Results: Polyclonal antisera contained antibodies that bound both to MPER and PIP. Immunoglobulin M mAbs were produced that bound both to the core MPER site of 2175, or that overlapped with the 4E10 site, and that simultaneously bound PIP. High concentrations of these mAbs neutralized infection of peripheral blood lymphocytes by a primary infectious molecular clone of HIV-1. Conclusion: Liposomes containing MPER peptide as an antigen, PIP as a lipid antigen, and lipid A as an adjuvant induce anti-MPER-specific multispecific antibodies that simultaneously bind glycoprotein 41 MPER and adjacent lipid and neutralize HIV-1 infection in a human peripheral blood mononuclear cell assay. (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins C1 [Matyas, Gary R.; Wieczorek, Lindsay; Beck, Zoltan; Michael, Nelson L.; Polonis, Victoria R.; Alving, Carl R.] US Mil HIV Res Program, Div Retrovirol, Walter Reed Army Inst Res, Rockville, MD 20850 USA. [Wieczorek, Lindsay; Beck, Zoltan] Henry M Jackson Fdn Adv Mil Med, Rockville, MD USA. [Ochsenbauer-Jambor, Christina; Kappes, John C.] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA. [Kappes, John C.] Vet Affairs Med Ctr, Res Serv, Birmingham, MD USA. RP Matyas, GR (reprint author), US Mil HIV Res Program, Div Retrovirol, Walter Reed Army Inst Res, 1600 E Gude Dr, Rockville, MD 20850 USA. EM gmatyas@hivresearch.org OI Matyas, Gary/0000-0002-2074-2373 FU Cooperative Agreement [W81XWH-07-2-0067]; U.S. Army Medical Research and Material Command; NIH Center for HIV/AIDS Vaccine Immunology [UO1 AI067854] FX The authors acknowledge the technical assistance of Ms. Tam Dinh and Ms. Gautami Inamdar for the ELISA studies and Marvin Walker for peptide synthesis. The human IgG antiphospholipid mAb CL1 was kindly supplied as a gift by Drs Pojen Chen [University of California, Los Angeles (UCLA)] and Barton Haynes (Duke University). This work was supported through Cooperative Agreement contract no. W81XWH-07-2-0067 between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the U.S. Army Medical Research and Material Command. The work of C.O. J. and J.C.K. was supported by the NIH Center for HIV/AIDS Vaccine Immunology, grant number UO1 AI067854, and facilitated by the University of Alabama at Birmingham (UAB) Center for AIDS Research (CFAR) Virology Core. NR 56 TC 52 Z9 52 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 EI 1473-5571 J9 AIDS JI Aids PD OCT 23 PY 2009 VL 23 IS 16 BP 2069 EP 2077 DI 10.1097/QAD.0b013e32832faea5 PG 9 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 517FS UT WOS:000271599200001 PM 19710597 ER PT J AU Roy, CJ Reed, DS Wilhelmsen, CL Hartings, J Norris, S Steele, KE AF Roy, Chad J. Reed, Douglas S. Wilhelmsen, Catherine L. Hartings, Justin Norris, Sarah Steele, Keith E. TI Pathogenesis of aerosolized Eastern Equine Encephalitis virus infection in guinea pigs SO VIROLOGY JOURNAL LA English DT Article ID BALB/C MICE; CYNOMOLGUS MACAQUES; ENCEPHALOMYELITIS; STRAINS; NEUROINVASION AB Mice and guinea pigs were experimentally exposed to aerosols containing regionally-distinct strains (NJ1959 or ArgM) of eastern equine encephalitis virus (EEEV) at two exclusive particle size distributions. Mice were more susceptible to either strain of aerosolized EEEV than were guinea pigs; however, clinical signs indicating encephalitis were more readily observed in the guinea pigs. Lower lethality was observed in both species when EEEV was presented at the larger aerosol distribution (> 6 mu m), although the differences in the median lethal dose (LD50) were not significant. Virus isolation and immunohistochemistry indicated that virus invaded the brains of guinea pigs within one day postexposure, regardless of viral strain or particle size distribution. Immunohistochemistry further demonstrated that neuroinvasion occurred through the olfactory system, followed by transneuronal spread to all regions of the brain. Olfactory bipolar neurons and neurons throughout the brain were the key viral targets. The main microscopic lesions in infected guinea pigs were neuronal necrosis, inflammation of the meninges and neuropil of the brain, and vasculitis in the brain. These results indicate that guinea pigs experimentally infected by aerosolized EEEV recapitulate several key features of fatal human infection and thus should serve as a suitable animal model for aerosol exposure to EEEV. C1 [Roy, Chad J.] Tulane Natl Primate Res Ctr, Div Microbiol, Covington, LA USA. [Reed, Douglas S.] Univ Pittsburgh, Ctr Vaccine Res, Pittsburgh, PA USA. [Wilhelmsen, Catherine L.; Norris, Sarah] USA, Med Res Inst Infect Dis, Off Commander, Ft Detrick, MD 21702 USA. [Hartings, Justin] Biaera Technol LLC, Frederick, MD USA. [Steele, Keith E.] USA, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. RP Roy, CJ (reprint author), Tulane Natl Primate Res Ctr, Div Microbiol, Covington, LA USA. EM croy@tulane.edu; dsreed@pitt.edu; cathy.wilhelmsen@det.usamriid.army.mil; jhartings@biaera.com; sarah.norris@us.army.mil; keith.steele1@us.army.mil OI Reed, Douglas/0000-0003-0076-9023 FU Medical Biological Defense Research Program; U. S. Army Medical Research and Materiel Command, USAMRIID [01-0-KR-001] FX The views, opinions, and/or findings contained herein are those of the authors and should not be construed as an official Department of Army position, policy, or decision unless so designated by other documentation. The research described herein was sponsored by the Medical Biological Defense Research Program, U. S. Army Medical Research and Materiel Command, USAMRIID project number 01-0-KR-001. The authors would like to thank the technicians in the Center for Aerobiological Sciences, the Veterinary Medicine Division, and the Pathology Division, USAMRIID, that assisted with these studies. NR 28 TC 21 Z9 22 U1 0 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-422X J9 VIROL J JI Virol. J. PD OCT 23 PY 2009 VL 6 AR 170 DI 10.1186/1743-422X-6-170 PG 13 WC Virology SC Virology GA 518GS UT WOS:000271679400001 PM 19852817 ER PT J AU Thompson, AP Plimpton, SJ Mattson, W AF Thompson, Aidan P. Plimpton, Steven J. Mattson, William TI General formulation of pressure and stress tensor for arbitrary many-body interaction potentials under periodic boundary conditions SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID SIMULATIONS; EWALD; FORCE AB Three distinct forms are derived for the force virial contribution to the pressure and stress tensor of a collection of atoms interacting under periodic boundary conditions. All three forms are written in terms of forces acting on atoms, and so are valid for arbitrary many-body interatomic potentials. All three forms are mathematically equivalent. In the special case of atoms interacting with pair potentials, they reduce to previously published forms. (i) The atom-cell form is similar to the standard expression for the virial for a finite nonperiodic system, but with an explicit correction for interactions with periodic images. (ii) The atom form is particularly suited to implementation in modern molecular dynamics simulation codes using spatial decomposition parallel algorithms. (iii) The group form of the virial allows the contributions to the virial to be assigned to individual atoms. (C) 2009 American Institute of Physics. [doi: 10.1063/1.3245303] C1 [Thompson, Aidan P.; Plimpton, Steven J.] Sandia Natl Labs, Albuquerque, NM 87185 USA. [Mattson, William] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Thompson, AP (reprint author), Sandia Natl Labs, POB 5800,MS 1110, Albuquerque, NM 87185 USA. EM athomps@sandia.gov FU Laboratory Directed Research and Development program at Sandia National Laboratories; United States Department of Energy [DE-AC04-94AL85000]; Department of Defense High Performance Computing Modernization Program Software Application Institute for Multiscale Reactive Modeling of Insensitive Munitions FX This work was supported by the Laboratory Directed Research and Development program at Sandia National Laboratories, a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Co., for the United States Department of Energy, under Contract No. DE-AC04-94AL85000. This work was supported in part by the Department of Defense High Performance Computing Modernization Program Software Application Institute for Multiscale Reactive Modeling of Insensitive Munitions. NR 11 TC 84 Z9 85 U1 4 U2 34 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD OCT 21 PY 2009 VL 131 IS 15 AR 154107 DI 10.1063/1.3245303 PG 6 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 512CA UT WOS:000271219000010 PM 20568847 ER PT J AU Sun, W Luo, CY Naik, RS Doctor, BP Saxena, A AF Sun, Wei Luo, Chunyuan Naik, Ramachandra S. Doctor, Bhupendra P. Saxena, Ashima TI Pharmacokinetics and immunologic consequences of repeated administrations of purified heterologous and homologous butyrylcholinesterase in mice SO LIFE SCIENCES LA English DT Article DE Pharmacokinetics; Anti-BChE antibodies; Bioscavenger; Human BChE; Mouse BChE; Mice ID HUMAN SERUM BUTYRYLCHOLINESTERASE; HALF-LIFE; RHESUS-MONKEYS; CHOLINESTERASE; ACETYLCHOLINESTERASE; PROTECTION; PLASMA; TOXICITY; SOMAN AB Aim: To assess the consequences of repeated administrations of purified human serum butyrylcholinesterase (Hu BChE) and mouse serum (Mo) BChE into mice. Main methods: Purified Hu BChE and Mo BChE isolated from the sera of CD-1 mice were administered into Balb/c or CD-1 mice. The enzymes were delivered by i.m. injections of similar to 100 U (0.15 mg) on day I and on day 28, respectively. The effects of two injections were monitored by following blood BChE and anti-BChE IgG levels. Key findings: Hu BChE displayed a mean residence time (MRT) of 50 h, and an area under the curve (AUC) of 1220 U/ml . h in Balb/c or CD-1 mice. Mo BChE exhibited an MRT of 78 h and an AUC of 1815 U/ml . h in Balb/c mice; the AUC increased to 2504 U/ml . h in CD-1 mice. A second injection of Hu BChE in both strains exhibited a marked reduction in circulatory stability. The circulatory stability of the second injection of Mo BChE was reduced in Balb/c mice, but was almost identical to the first injection in CD-1 mice. Consistent with these observations, circulating anti-BChE IgGs were observed in mice injected with Hu BChE; low levels of anti-BChE IgGs were observed only in Balb/c mice injected with Mo BChE. No antibody response was detected in CD-1 mice following either injection of homologous Mo BChE. Significance: The identical pharmacokinetic profiles and the absence of an immunologic response following a second administration of homologous BChE support the development of Hu BChE as a detoxifying drug in humans. (C) 2009 Published by Elsevier Inc. C1 [Sun, Wei; Luo, Chunyuan; Naik, Ramachandra S.; Saxena, Ashima] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. [Doctor, Bhupendra P.] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. RP Saxena, A (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Ashima.saxena@us.army.mil FU Defense Threat Reduction Agency FX This work was supported by a funding from the Defense Threat Reduction Agency. NR 23 TC 6 Z9 6 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0024-3205 J9 LIFE SCI JI Life Sci. PD OCT 21 PY 2009 VL 85 IS 17-18 BP 657 EP 661 DI 10.1016/j.lfs.2009.09.005 PG 5 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA 510IT UT WOS:000271082400007 PM 19772863 ER PT J AU Bronk, BV Druger, SD AF Bronk, Burt V. Druger, Stephen D. TI Light scattering calculations exploring sensitivity of depolarization ratio to shape changes. II. Single rod-shaped vegetative bacteria in air SO APPLIED OPTICS LA English DT Article ID DISCRETE-DIPOLE APPROXIMATION; OPTICAL-PROPERTIES; IN-VIVO; CONVERGENCE; REGION AB In article I of this series, calculations and graphs of the depolarization ratio, D(Theta, lambda) = 1 - < S-22 > = < S-11 >, for light scattered from an ensemble of single-aerosolized Bacillus spores using the discrete dipole approximation (DDA) (sometimes also called the coupled dipole approximation) were presented. The Sij in these papers denote the appropriate Mueller matrix elements. We compare graphs for different size parameters for both D(Theta, lambda) and the ratio R-34(Theta, lambda) = < S-34 > = < S-11 >. The ratio R-34(Theta, lambda) was shown previously to be sensitive to diameters of rod-shaped and spherical bacteria suspended in liquids. The present paper isolates the effect of length changes and shows that R-34(Theta, lambda) is not very sensitive to these changes, but D(Theta, lambda) is sensitive to length changes when the aspect ratio becomes small enough. In the present article, we extend our analysis to vegetative bacteria which, because of their high percentage of water, generally have a substantially lower index of refraction than spores. The parameters used for the calculations were chosen to simulate values previously measured for log-phase Escherichia coli. Each individual E. coli bacterium appears microscopically approximately like a right-circular cylinder, capped smoothly at each end by a hemisphere of the same diameter. With the present model we focus particular attention on determining the effect, if any, of length changes on the graphs of D(Theta, lambda) and R-34(Theta, lambda). We study what happens to these two functions when the diameters of the bacteria remain constant and their basic shape remains that of a capped cylinder, but with total length changed by reducing the length of the cylindrical part of each cell. This approach also allows a test of the model, since the limiting case as the length of the cylindrical part approaches zero is exactly a sphere, which is known to give a value identically equal to zero for D(Theta, lambda) but not for R-34(Theta, lambda). (C) 2009 Optical Society of America C1 [Bronk, Burt V.] USAF, Res Lab, Wright Patterson AFB, OH 45433 USA. [Bronk, Burt V.] USA, ECBC, Aberdeen Proving Ground, MD 21010 USA. [Druger, Stephen D.] Univ Massachusetts, Dept Phys & Appl Phys, Lowell, MA 01854 USA. RP Bronk, BV (reprint author), USAF, Res Lab, 711 HPW, Wright Patterson AFB, OH 45433 USA. EM burt.bronk@hotmail.com NR 16 TC 4 Z9 4 U1 0 U2 5 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD OCT 20 PY 2009 VL 48 IS 30 BP 5655 EP 5663 DI 10.1364/AO.48.005655 PG 9 WC Optics SC Optics GA 514DG UT WOS:000271373900003 PM 19844297 ER PT J AU Rueda, LM Brown, TL Kim, HC Klein, TA Thongkukiatkul, A Sherwood, V AF Rueda, Leopoldo M. Brown, Tracy L. Kim, Heung-Chul Klein, Terry A. Thongkukiatkul, Amporn Sherwood, Van TI Description and comparison of morphological structures of the eggs of Anopheles hyrcanus group and related species (Diptera: Culicidae) from the Republic of Korea SO ZOOTAXA LA English DT Article DE Culicidae; Anopheles; mosquito eggs; morphology; Republic of Korea ID SINENSIS AB The eggs of six Anopheles Hyrcanus Group (An. sinensis Wiedemann, An. kleini Rueda, An. belenrae Rueda, An. pullus M. Yamada, An. lesteri Baisas and Hu, An. sineroides S. Yamada) and related species (An. koreicus S. Yamada and Watanabe, An. lindesayi japonicus S. Yamada), were described from scanning electron micrographs of specimens collected from different localities of the Republic of Korea. Morphometric measurements of egg samples of the eight species were compared and relationships analyzed by multivariate statistics. About 27 characters were selected and used as a basis for principal and discriminant function analyses. Scanning electron micrographs of various parts of the eggs were selected to illustrate interspecific differences for particular morphological features (e. g. anterior and posterior tubercles, decks, plastron, micropyles, floats). C1 [Rueda, Leopoldo M.; Brown, Tracy L.; Sherwood, Van] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA. [Rueda, Leopoldo M.; Brown, Tracy L.] Smithsonian Inst, Walter Reed Biosystemat Unit, Museum Support Ctr, MRC 534, Suitland, MD 20746 USA. [Kim, Heung-Chul] 65th Med Brigade, Multifunct Med Battal 168, Med Detachment 5, APO, AP 96205 USA. [Klein, Terry A.] USAMEDDAC Korea, Med Brigade 65, Force Hlth Protect & Prevent Med, APO, AP 96205 USA. [Thongkukiatkul, Amporn] Burapha Univ, Dept Biol, Chon Buri, Thailand. RP Rueda, LM (reprint author), Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA. EM ruedapol@si.edu RI Valle, Ruben/A-7512-2013 FU Center for Health Promotion and Preventive Medicine; Global Emerging Infections Surveillance and Response Systems, Silver Spring, MD FX Funding for this work was provided by the Center for Health Promotion and Preventive Medicine, Global Emerging Infections Surveillance and Response Systems, Silver Spring, MD. This research was performed under a Memorandum of Understanding between the Walter Reed Army Institute of Research and the Smithsonian Institution, with institutional support provided by both organizations. The opinions and assertions contained herein are those of the authors and are not to be construed as official or reflecting the views of the Department of the Army or the Department of Defense. NR 17 TC 2 Z9 2 U1 0 U2 0 PU MAGNOLIA PRESS PI AUCKLAND PA PO BOX 41383, AUCKLAND, ST LUKES 1030, NEW ZEALAND SN 1175-5326 EI 1175-5334 J9 ZOOTAXA JI Zootaxa PD OCT 20 PY 2009 IS 2268 BP 23 EP 40 PG 18 WC Zoology SC Zoology GA 508KM UT WOS:000270929700002 ER PT J AU Shi, XR Curran, JE Liao, ZL Gordon, RK AF Shi, Xuerong Curran, Jennifer E. Liao, Zhilin Gordon, Richard K. TI The Biological Activity of Ubiquitinated BoNT/B Light Chain In Vitro and in Human SHSY-5Y Neuronal Cells SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Article DE UBIQUITINATION; UBIQUITIN; BoNT; BOTULINUM NEUROTOXIN; SYNAPTOBREVIN-2; VAMP-2 ID AMINO-ACID-SEQUENCE; BOTULINUM NEUROTOXIN; PROTEIN-DEGRADATION; HUMAN NEUROBLASTOMA; CONJUGATING ENZYME; PROTEASOME; RELEASE; TETANUS; TOXIN; RETICULOCYTES AB BoNT/B light chain is a zinc-dependent endopeptidase. After entering its target, the neuronal cell, BoNT/B is responsible for synaptobrevin-2 (VAMP-2) cleavage. This results in reduced neurotransmitter (acetylcholine) release from synaptic vesicles, yielding muscular paralysis. Since the toxin persists in neuronal cells for all extended period, regeneration of VAMP-2 is prevented. We evaluated therapeutic targets to overcome botulinum persistence because early removal would rescue the neuronal cell. The ubiquitination/proteasome cellular pathway is responsible for removing "old" or undesirable proteins. Therefore, we assessed ubiquitination of BoNT/B light chain in vitro, and characterized the effects of ubiquitination modulating drugs, PMA (phorbol 12-myristate 13-acetate) and expoxomicin, on ubiquitination of BoNT/B light chain in neuronal cells. Both drugs altered BoNT/B light chain ubiquitination. Ubiquitination in vitro and in cells decreased the biological activity of BoNT/B light chain. These results further elucidate BoNT protein degradation pathways in intoxicated neuronal cells and mechanisms to enhance toxin removal. J. Cell. Biochem. 108: 660-667, 2009. (C) 2009 Wiley-Liss, Inc. C1 [Shi, Xuerong; Curran, Jennifer E.; Liao, Zhilin; Gordon, Richard K.] Walter Reed Army Inst Res, Dept Regulated Labs, Div Regulated Act, Silver Spring, MD 20910 USA. RP Shi, XR (reprint author), Walter Reed Army Inst Res, Dept Regulated Labs, Div Regulated Act, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM xuerong.shi@amedd.army.mil FU Defense Threat Reduction Agency (DTRA) [3.10017_06_WR_B] FX Grant sponsor: Defense Threat Reduction Agency (DTRA); Grant number: #3.10017_06_WR_B. NR 43 TC 3 Z9 3 U1 1 U2 3 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD OCT 15 PY 2009 VL 108 IS 3 BP 660 EP 667 DI 10.1002/jcb.22300 PG 8 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA 503UU UT WOS:000270567100013 PM 19681043 ER PT J AU Cooke, WH Rickards, CA Ryan, KL Kuusela, TA Convertino, VA AF Cooke, William H. Rickards, Caroline A. Ryan, Kathy L. Kuusela, Tom A. Convertino, Victor A. TI Muscle sympathetic nerve activity during intense lower body negative pressure to presyncope in humans SO JOURNAL OF PHYSIOLOGY-LONDON LA English DT Article ID HEART-RATE-VARIABILITY; BLOOD-PRESSURE; VASOVAGAL SYNCOPE; HEMORRHAGIC-SHOCK; NEURAL-CONTROL; UPRIGHT TILT; HYPOTENSION; RESPONSES; OUTFLOW; FLUCTUATIONS AB Activation of sympathetic efferent traffic is essential to maintaining adequate arterial pressures during reductions of central blood volume. Sympathetic baroreflex gain may be reduced, and muscle sympathetic firing characteristics altered with head-up tilt just before presyncope in humans. Volume redistributions with lower body negative pressure (LBNP) are similar to those that occur during haemorrhage, but limited data exist describing arterial pressure-muscle sympathetic nerve activity (MSNA) relationships during intense LBNP. Responses similar to those that occur in presyncopal subjects during head-up tilt may signal the beginnings of cardiovascular decompensation associated with haemorrhage. We therefore tested the hypotheses that intense LBNP disrupts MSNA firing characteristics and leads to a dissociation between arterial pressure and sympathetic traffic prior to presyncope. In 17 healthy volunteers (12 males and 5 females), we recorded ECG, finger photoplethysmographic arterial pressure and MSNA. Subjects were exposed to 5 min LBNP stages until the onset of presyncope. The LBNP level eliciting presyncope was denoted as 100% tolerance, and then data were assessed relative to this normalised maximal tolerance by expressing LBNP levels as 80, 60, 40, 20 and 0% (baseline) of maximal tolerance. Data were analysed in both time and frequency domains, and cross-spectral analyses were performed to determine the coherence, transfer function and phase angle between diastolic arterial pressure (DAP) and MSNA. DAP-MSNA coherence increased progressively and significantly up to 80% maximal tolerance. Transfer functions were unchanged, but phase angle shifted from positive to negative with application of LBNP. Sympathetic bursts fused in 10 subjects during high levels of LBNP (burst fusing may reflect modulation of central mechanisms, an artefact arising from our use of a 0.1s time constant for integrating filtered nerve activity, or a combination of both). On average, arterial pressures and MSNA decreased significantly the final 20s before presyncope (n = 17), but of this group, MSNA increased in seven subjects. No linear relationship was observed between the magnitude of DAP and MSNA changes before presyncope (r = 0.12). We report three primary findings: (1) progressive LBNP (and presumed progressive arterial baroreceptor unloading) increases cross-spectral coherence between arterial pressure and MSNA, but sympathetic baroreflex control is reduced before presyncope; (2) withdrawal of MSNA is not a prerequisite for presyncope despite significant decreases of arterial pressure; and (3) reductions of venous return, probably induced by intense LBNF, disrupt MSNA firing characteristics that manifest as fused integrated bursts before the onset of presyncope. Although fusing of integrated sympathetic bursts may reflect a true physiological compensation to severe reductions of venous return, duplication of this finding utilizing shorter time constants for integration of the nerve signal is required. C1 [Cooke, William H.; Rickards, Caroline A.] Univ Texas San Antonio, Dept Hlth & Kinesiol, San Antonio, TX 78249 USA. [Rickards, Caroline A.; Ryan, Kathy L.; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Kuusela, Tom A.] Univ Turku, Dept Phys, SF-20500 Turku, Finland. RP Cooke, WH (reprint author), Univ Texas San Antonio, Dept Hlth & Kinesiol, 1 UTSA Circle, San Antonio, TX 78249 USA. EM william.cooke@utsa.edu FU United States Department of Defense, Medical Research and Materiel Command FX We thank the research volunteers for their cheerful participation and Mr Gary Muniz for his excellent laboratory assistance. This study was funded by the United States Department of Defense, Medical Research and Materiel Command. NR 47 TC 58 Z9 58 U1 0 U2 1 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0022-3751 J9 J PHYSIOL-LONDON JI J. Physiol.-London PD OCT 15 PY 2009 VL 587 IS 20 BP 4987 EP 4999 DI 10.1113/jphysiol.2009.177352 PG 13 WC Neurosciences; Physiology SC Neurosciences & Neurology; Physiology GA 516BZ UT WOS:000271518000020 PM 19703962 ER PT J AU Anez, G Men, RH Eckels, KH Lai, CJ AF Anez, German Men, Ruhe Eckels, Kenneth H. Lai, Ching-Juh TI Passage of Dengue Virus Type 4 Vaccine Candidates in Fetal Rhesus Lung Cells Selects Heparin-Sensitive Variants That Result in Loss of Infectivity and Immunogenicity in Rhesus Macaques SO JOURNAL OF VIROLOGY LA English DT Article ID GLYCOSAMINOGLYCAN-BINDING VARIANTS; JAPANESE ENCEPHALITIS-VIRUS; HUMAN DENDRITIC CELLS; PROTEIN DOMAIN-III; WEST-NILE-VIRUS; ENVELOPE PROTEIN; VIRULENCE ATTENUATION; PUTATIVE RECEPTOR; E2 GLYCOPROTEIN; SULFATE BINDING AB Three dengue virus type 4 (DENV-4) vaccine candidates containing deletions in the 3' noncoding region were prepared by passage in DBS-FRhL-2 (FRhL) cells. Unexpectedly, these vaccine candidates and parental DENV-4 similarly passaged in the same cells failed to elicit either viremia or a virus-neutralizing antibody response. Consensus sequence analysis revealed that each of the three viruses, as well as the parental DENV-4 when passaged in FRhL cells, rapidly acquired a single Glu(327)-Gly substitution in domain III (DIII) of the envelope protein (E). These variants appear to have accumulated in response to growth adaptation to FRhL cells as shown by growth analysis, and the mutation was not detected in the virus following passage in C6/36 cells, primary African green monkey kidney cells, or Vero cells. The Glu(327)-Gly substitution was predicted by molecular modeling to increase the net positive charge on the surface of E. The Glu(327)-Gly variant of the full-length DENV-4 selected after three passages in FRhL cells showed increased affinity for heparan sulfate compared to the unpassaged DENV-4, as measured by heparin binding and infectivity inhibition assays. Evidence indicates that the Glu(327)-Gly mutation in DIII of the DENV-4 E protein was responsible for reduced infectivity and immunogenicity in rhesus monkeys. Our results point out the importance of cell substrates for vaccine preparation since the virus may change during passages in certain cells through adaptive selection, and such mutations may affect cell tropism, virulence, and vaccine efficacy. C1 [Anez, German; Men, Ruhe; Lai, Ching-Juh] NIAID, Mol Viral Biol Sect, Infect Dis Lab, NIH, Bethesda, MD 20892 USA. [Eckels, Kenneth H.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Lai, CJ (reprint author), NIAID, Mol Viral Biol Sect, Infect Dis Lab, NIH, 50 South Dr, Bethesda, MD 20892 USA. EM clai@niaid.nih.gov RI Anez, German/B-3643-2008 OI Anez, German/0000-0001-5361-3001 FU Intramural Research Program of the National Institute of Allergy and Infectious Diseases; National Institutes of Health FX This work was supported by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases, National Institutes of Health. This research project received partial financial support from the WHO Global Programme for Vaccines. NR 57 TC 31 Z9 32 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD OCT 15 PY 2009 VL 83 IS 20 BP 10384 EP 10394 DI 10.1128/JVI.01083-09 PG 11 WC Virology SC Virology GA 498FC UT WOS:000270121600007 PM 19656873 ER PT J AU Hilmas, CJ Poole, MJ Finneran, K Clark, MG Williams, PT AF Hilmas, Corey J. Poole, Melissa J. Finneran, Kathryn Clark, Matthew G. Williams, Patrick T. TI Galantamine is a novel post-exposure therapeutic against lethal VX challenge SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article DE Galantamine; Neuroprotection; Muscle paralysis; Nerve agent; Electroencephalography; Survival ID ALZHEIMERS-DISEASE; NERVE AGENTS; ACETYLCHOLINESTERASE; INHIBITION; SOMAN; PYRIDOSTIGMINE; PROTECTION; ATROPINE; SARIN; GALANTHAMINE AB The ability of galantamine hydrobromide (GAL HBr) treatment to antagonize O-ethyl-S-(2-diisopropylaminoethyl) methylphosphonothiolate (VX)-induced lethality, impairment of muscle tension, and electroencephalographic (EEG) changes was assessed in guinea pigs. Guinea pigs were challenged with 16.8 mu g/kg VX (2LD50). One min after challenge, animals were administered 0.5 mg/kg atropine sulfate (ATR) and 25 mg/kg pyridine-2-aldoxime methochloride (2-PAM). In addition, guinea pigs were given 0, 1, 2, 4, 8 or 10 mg/kg GAL as a post-exposure treatment immediately prior to ATR and 2-PAM. Animals were either monitored for 24-h survival, scheduled for electroencephalography (EEG) recording, or euthanized 60 min later for measurement of indirectly-elicited muscle tension in the hemidiaphragm. Post-exposure GAL therapy produced a dose-dependent increase in survival from lethal VX challenge. Optimal clinical benefits were observed in the presence of 10 mg/kg GAL, which led to 100% Survival of VX-challenged guinea pigs. Based on muscle physiology studies, GAL post-exposure treatment protected the guinea pig diaphragm, the major effector muscle of respiration. from fatigue, tetanic fade, and muscular paralysis. Protection against the paralyzing effects of VX was dose-dependent. In EEG studies, GAL did not alter seizure onset for all doses tested. At the highest dose tested ( 10 mg/kg), GAL decreased seizure duration when administered as a post-exposure treatment I min after VX. GAL also reduced the high correlation associated between seizure activity and lethality after 2LD50 VX challenge. GAL may have additional benefits both centrally and peripherally that are unrelated to its established mechanism as a reversible acetylcholinesterase inhibitor (AChEI). Published by Elsevier Inc. C1 [Hilmas, Corey J.; Finneran, Kathryn; Williams, Patrick T.] USA, Med Res Inst Chem Def, Neurobehav Toxicol Branch, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA. [Poole, Melissa J.] Johns Hopkins Univ, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21287 USA. [Clark, Matthew G.] USA, Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP Hilmas, CJ (reprint author), USA, Med Res Inst Chem Def, Neurobehav Toxicol Branch, Analyt Toxicol Div, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM corey.john.hilmas@us.army.mil FU Defense Threat Reduction Agency - Joint Science and Technology Office, Medical ST Division [1. E0019_07RC_C] FX The authors thank the US Army Medical Research and Materiel Command and the Defense Threat Reduction Agency for funding. This research was supported by the Defense Threat Reduction Agency - Joint Science and Technology Office, Medical S&T Division (grant 1. E0019_07RC_C). The authors would also like to thank Mr. Richard Sweeney and Mr. Alexandre Katos for 3D modeling and medical illustrations provided in this manuscript. NR 33 TC 12 Z9 12 U1 0 U2 8 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD OCT 15 PY 2009 VL 240 IS 2 BP 166 EP 173 DI 10.1016/j.taap.2009.07.029 PG 8 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 503TE UT WOS:000270562100007 PM 19647007 ER PT J AU Lowery, CA Park, J Gloeckner, C Meijler, MM Mueller, RS Boshoff, HI Ulrich, RL Barry, CE Bartlett, DH Kravchenko, VV Kaufmann, GF Janda, KD AF Lowery, Colin A. Park, Junguk Gloeckner, Christian Meijler, Michael M. Mueller, Ryan S. Boshoff, Helena I. Ulrich, Ricky L. Barry, Clifton E., III Bartlett, Douglas H. Kravchenko, Vladimir V. Kaufmann, Gunnar F. Janda, Kim D. TI Defining the Mode of Action of Tetramic Acid Antibacterials Derived from Pseudomonas aeruginosa Quorum Sensing Signals SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Article ID GRAM-NEGATIVE BACTERIA; ESCHERICHIA-COLI; NATURAL-PRODUCTS; VIBRIO-CHOLERAE; OUTER-MEMBRANE; SMALL-MOLECULE; CELL-DIVISION; IDENTIFICATION; GENE; REUTERICYCLIN AB In nature, bacteria rarely exist as single, isolated entities, but rather as communities comprised of many other species including higher host organisms. To survive in these competitive environments, microorganisms have developed elaborate tactics such as the formation of biofilms and the production of antimicrobial toxins. Recently, it was discovered that the Gram-negative bacterium Pseudomonas aeruginosa, an opportunistic human pathogen, produces an antibiotic, 3-(1-hydroxydecylidene)-5-(2-hydroxyethyl)pyrrolidine-2,4-dione (C(12)-TA), derived from one of its quorum sensing molecules. Here, we present a comprehensive study of the expanded spectrum Of C(12)-TA antibacterial activity against microbial competitors encountered by P. aeruginosa in nature as well as significant human pathogens. The mechanism of action Of C(12)-TA was also elucidated, and C(12)-TA was found to dissipate both the membrane potential and the pH gradient of Gram-positive bacteria, correlating well with cell death. Notably, in stark contrast to its parent molecule 3-oxo-dodecanoyl homoserine lactone (3-oxo-C(12)-HSL), neither activation of cellular stress pathways nor cytotoxicity was observed in human cells treated with C(12)-TA. Our results suggest that the QS machinery of P. aeruginosa has evolved for a dual-function, both to signal others of the same species and also to defend against host immunity and competing bacteria. Because of the broad-spectrum antibacterial activity, established mode of action, lack of rapid resistance development, and tolerance by human cells, the C(12)-TA scaffold may also serve as a new lead compound for the development of antimicrobial therapeutics. C1 [Lowery, Colin A.; Park, Junguk; Gloeckner, Christian; Meijler, Michael M.; Kaufmann, Gunnar F.; Janda, Kim D.] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA. [Lowery, Colin A.; Park, Junguk; Gloeckner, Christian; Meijler, Michael M.; Kaufmann, Gunnar F.; Janda, Kim D.] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA. [Lowery, Colin A.; Park, Junguk; Gloeckner, Christian; Meijler, Michael M.; Kravchenko, Vladimir V.; Kaufmann, Gunnar F.; Janda, Kim D.] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA. [Mueller, Ryan S.; Bartlett, Douglas H.] Univ Calif San Diego, Scripps Inst Oceanog, Div Marine Biol Res, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92037 USA. [Boshoff, Helena I.; Barry, Clifton E., III] NIAID, TB Res Sect, Bethesda, MD 20892 USA. [Ulrich, Ricky L.] USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21704 USA. [Janda, Kim D.] Scripps Res Inst, WIRM, La Jolla, CA 92037 USA. RP Kaufmann, GF (reprint author), Scripps Res Inst, Skaggs Inst Chem Biol, 10550 N Torrey Pines Rd, La Jolla, CA 92037 USA. EM kaufmann@scripps.edu; kdjanda@scripps.edu RI Barry, III, Clifton/H-3839-2012 FU NIAID/NIH [HHSN272200700055C]; National Institutes of Health [AI079503, AI080715, AI079436]; Skaggs Institute for Chemical Biology; Sanofi-Aventis; NIAID, NIH FX We thank Professor Michael Ganzle of the University of Alberta, Edmonton, AB, Canada, for generously providing us with reutericyclin, and 'Prof. Floyd Romesberg for providing the mutant E. coli strains. The following isolate was obtained through the Network on Antimicrobial Resistance in Staphylococcus aureus (NARSA) Program: Staphylococcus aureus USA300 (NRS384), supported under NIAID/NIH contract no. HHSN272200700055C. We would also like to thank Prof. Bastiaan P. Krom of the University of Groningen for critical reading of the manuscript. This work was supported by the National Institutes of Health (AI079503 to K.D.J., AI080715 to G.F.K., AI079436 to V.V.K.), the Skaggs Institute for Chemical Biology, and a Sanofi-Aventis Graduate Fellowship (C.A.L.), and in part by the Intramural Research program of the NIAID, NIH. NR 44 TC 50 Z9 51 U1 4 U2 22 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD OCT 14 PY 2009 VL 131 IS 40 BP 14473 EP 14479 DI 10.1021/ja9056079 PG 7 WC Chemistry, Multidisciplinary SC Chemistry GA 512SS UT WOS:000271271500087 PM 19807189 ER PT J AU Loder, NM Irish, JL Cialone, MA Wamsley, TV AF Loder, N. M. Irish, J. L. Cialone, M. A. Wamsley, T. V. TI Sensitivity of hurricane surge to morphological parameters of coastal wetlands SO ESTUARINE COASTAL AND SHELF SCIENCE LA English DT Article DE flooding; hurricanes; marsh; storm surge; surge response; wetlands; USA; Gulf of Mexico ID FLOW; RESISTANCE; VEGETATION; MODEL; DRAG AB Given the history and future risk of storm surge in the United States, functional storm protection techniques are needed to protect vital sectors of the economy and coastal communities. It is widely hypothesized that coastal wetlands offer protection from storm surge and wave action, though the extent of this protection is unknown due to the complexities of flow through vegetation. Here we present the sensitivity of storm-surge numerical modeling results to various coastal wetlands characteristics. An idealized grid domain and 400-km(2) marsh feature were used to evaluate the effects of marsh characteristics on hurricane surge, including the effects of bottom friction, elevation, and continuity (the ratio of healthy marsh to open water area within the total wetland area). Through coupled hydrodynamic and wave model simulations, it is confirmed that increased bottom friction reduces storm-surge levels for most storms. However, increases in depth associated with marsh elevation loss generally results in a reduction of surge. As marsh continuity is decreased, coastal surge increases as a result of enhanced surge conveyance into and out of the marsh. Storm surge is parameterized in terms of marsh morphology, namely marsh elevation, frictional characteristics, and degree of segmentation, which will assist in the justification for and optimization of marsh restoration in terms of storm protection. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Loder, N. M.; Irish, J. L.] Texas A&M Univ, Zachry Dept Civil Engn, College Stn, TX 77843 USA. [Cialone, M. A.; Wamsley, T. V.] USA, Coastal & Hydraul Lab, Ctr Res & Dev, Vicksburg, MS 39180 USA. RP Irish, JL (reprint author), Texas A&M Univ, Zachry Dept Civil Engn, 3135 TAMU, College Stn, TX 77843 USA. EM jirish@civil.tamu.edu OI Irish, Jennifer/0000-0002-2429-5953 FU US Army Engineer Research and Development Center and the Louisiana Coastal Area Science and Technology Program [C08-00010] FX All work was funded by the US Army Engineer Research and Development Center and the Louisiana Coastal Area Science and Technology Program through grant number C08-00010. The use of trade names does not constitute an endorsement in the use of these products by the US government. NR 26 TC 41 Z9 42 U1 5 U2 20 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0272-7714 J9 ESTUAR COAST SHELF S JI Estuar. Coast. Shelf Sci. PD OCT 10 PY 2009 VL 84 IS 4 BP 625 EP 636 DI 10.1016/j.ecss.2009.07.036 PG 12 WC Marine & Freshwater Biology; Oceanography SC Marine & Freshwater Biology; Oceanography GA 504VW UT WOS:000270646900021 ER PT J AU Saito, A Castanier, MP Pierre, C AF Saito, A. Castanier, M. P. Pierre, C. TI Estimation and veering analysis of nonlinear resonant frequencies of cracked plates SO JOURNAL OF SOUND AND VIBRATION LA English DT Article ID FRICTION-DAMPED SYSTEMS; BERNOULLI-EULER BEAMS; HARMONIC EXCITATION; MODE LOCALIZATION; RECTANGULAR PLATE; DYNAMIC-RESPONSE; CANTILEVER BEAM; LINEAR-SYSTEMS; FATIGUE CRACK; VIBRATION AB In this paper, veering phenomena in the nonlinear vibration frequencies of a cantilevered cracked plate are investigated, and an efficient method for estimating these frequencies is proposed. Of particular interest is the vibration response in parameter regions where the natural frequency loci show veerings. For a representative finite element model, it is shown that the veerings due to crack length variation involve the switching of mode shapes and modal interactions. The nonlinearity caused by the crack closing effect is then introduced, and its effect on the vibration response near the veerings is discussed. The nonlinear forced response analysis is carried Out using a hybrid frequency/time domain method, which is based on the method of harmonic balance. The nonlinear vibration response near loci veerings and crossings due to the variation of crack length is investigated in detail. Finally, a novel method for estimating the nonlinear resonant frequency is introduced by generalizing the concept of bilinear frequency approximation, and the method is validated with the results of nonlinear forced response analysis for several veering regions. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Saito, A.] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. [Castanier, M. P.] USA, Tank Automot Res Dev & Engn Ctr, Business Res Grp, Warren, MI 48397 USA. [Pierre, C.] McGill Univ, Fac Engn, Montreal, PQ H3A 2K6, Canada. RP Saito, A (reprint author), Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. EM asakira@umich.edu; matt.castanier@us.army.mil; christophe.pierre@mcgill.ca RI Saito, Akira/P-7335-2015; OI Saito, Akira/0000-0001-8102-3754; Castanier, Matthew/0000-0002-3646-382X NR 58 TC 23 Z9 25 U1 0 U2 12 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0022-460X EI 1095-8568 J9 J SOUND VIB JI J. Sound Vibr. PD OCT 9 PY 2009 VL 326 IS 3-5 BP 725 EP 739 DI 10.1016/j.jsv.2009.05.009 PG 15 WC Acoustics; Engineering, Mechanical; Mechanics SC Acoustics; Engineering; Mechanics GA 488ZF UT WOS:000269388300021 ER PT J AU Shukla, MK Dubey, M Zakar, E Namburu, R Czyznikowska, Z Leszczynski, J AF Shukla, M. K. Dubey, Madan Zakar, Eugene Namburu, Raju Czyznikowska, Zaneta Leszczynski, Jerzy TI Interaction of nucleic acid bases with single-walled carbon nanotube SO CHEMICAL PHYSICS LETTERS LA English DT Article ID BASIS-SETS; AB-INITIO; DNA; MP2 AB Theoretical investigations at the M05-2X DFT level employing the 6-31G(d), 6-31G(d,p), 6-31+G(d,p) and cc-pVDZ basis sets show that all nucleic acid bases (NABs), guanine, adenine, cytosine, thymine and uracil form stable stacking complexes with the zigzag (7,0) single-walled carbon nanotube (SWCNT). The values of the BSSE corrected interaction energy suggested that among the bases guanine forms the most stable complex. The other bases generate complexes of similar stability with the considered SWCNT that are less stable than the guanine-SWCNT dimer. (C) 2009 Elsevier B.V. All rights reserved. C1 [Shukla, M. K.; Czyznikowska, Zaneta; Leszczynski, Jerzy] Jackson State Univ, NSF, Dept Chem & Biochem, CREST,Interdisplinary Nanotox Ctr, Jackson, MS 39217 USA. [Dubey, Madan; Zakar, Eugene] USA, Sensor & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA. [Namburu, Raju] USA, Computat & Informat Sci Directorate, Res Lab, Adelphi, MD 20783 USA. RP Leszczynski, J (reprint author), Jackson State Univ, NSF, Dept Chem & Biochem, CREST,Interdisplinary Nanotox Ctr, Jackson, MS 39217 USA. EM jerzy@icnanotox.org FU Army Research Laboratory [W911QX-07-C-0100, ORNL CNMS2009-031]; NSF-CREST [HRD-0833178] FX M. K. S. and J. L. are thankful to supports from Army Research Laboratory Contract No. W911QX-07-C-0100, ORNL CNMS2009-031, and NSF-CREST Grant No. HRD-0833178. Authors are also thankful to ARL, Computational and Information Sciences Directorate Adelphi, MD 20783, USA for providing computational facility. NR 31 TC 35 Z9 36 U1 0 U2 16 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 EI 1873-4448 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD OCT 8 PY 2009 VL 480 IS 4-6 BP 269 EP 272 DI 10.1016/j.cplett.2009.09.031 PG 4 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 501ZI UT WOS:000270423000023 ER PT J AU Yathindranath, V Hegmann, T van Lierop, J Potter, K Fowler, CB Moore, DF AF Yathindranath, V. Hegmann, T. van Lierop, J. Potter, K. Fowler, C. B. Moore, D. F. TI Simultaneous magnetically directed drug convection and MR imaging SO NANOTECHNOLOGY LA English DT Article ID NANOPARTICLES; DELIVERY; CANCER; DISEASE; NANOCRYSTALS; HYPERTHERMIA; PROTEINS; RATS AB Superparamagnetic iron oxide nanoparticles (IO NPs) are of interest for their usefulness in biomedical applications. In this work, we have synthesized iron oxide nanocomposites surface-modified with different biocompatible polymers. Bovine serum albumin (BSA) was physisorbed onto these IO NPs along with an excipient during freeze-drying. The mass transport of the protein attached to the iron oxide core-shell nanoparticles (IO cs-NPs) under a gradient magnetic field of an MRI instrument was observed in vitro and in an egg as a model system for a biological fluid. From the in vitro experiments in agarose gels, it was observed that the protein gets separated from the core during mass transport for some cs-IO, but co-migration was observed for PEG-modified IO cs-NPs. These experiments demonstrated proof-of-concept for the use of IO cs-NPs in magnetically directed drug convection. C1 [Yathindranath, V.; Hegmann, T.] Univ Manitoba, Dept Chem, Winnipeg, MB R3T 2N2, Canada. [van Lierop, J.] Univ Manitoba, Dept Phys & Astron, Winnipeg, MB R3T 2N2, Canada. [Potter, K.; Fowler, C. B.] DVBIC DCoE AFIP, Traumat Brain Injury Res Ctr, Dept Biophys, Rockville, MD 20850 USA. [Moore, D. F.] Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20307 USA. RP Yathindranath, V (reprint author), Univ Manitoba, Dept Chem, Winnipeg, MB R3T 2N2, Canada. EM johan@physics.umanitoba.ca FU Shire Human Genetics Therapy; Manitoba Medical Service Foundation; Defense and Veterans Brain Injury Center; Canada Foundation for Innovation (CFI); Sciences and Engineering Research Council (NSERC) of Canada; UMGF; MGS programs FX We acknowledge financial support from Shire Human Genetics Therapy, the Manitoba Medical Service Foundation, the Defense and Veterans Brain Injury Center, the Canada Foundation for Innovation (CFI) and the Natural Sciences and Engineering Research Council (NSERC) of Canada. We thank Ruth Goldin for her expert technical support in the development of this work. VY gratefully acknowledges financial support from the UMGF and MGS programs. NR 45 TC 5 Z9 5 U1 1 U2 11 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND SN 0957-4484 J9 NANOTECHNOLOGY JI Nanotechnology PD OCT 7 PY 2009 VL 20 IS 40 AR 405101 DI 10.1088/0957-4484/20/40/405101 PG 12 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA 495XW UT WOS:000269929900001 PM 19738300 ER PT J AU Hill, KK Xie, G Foley, BT Smith, TJ Munk, AC Bruce, D Smith, LA Brettin, TS Detter, JC AF Hill, Karen K. Xie, Gary Foley, Brian T. Smith, Theresa J. Munk, Amy C. Bruce, David Smith, Leonard A. Brettin, Thomas S. Detter, John C. TI Recombination and insertion events involving the botulinum neurotoxin complex genes in Clostridium botulinum types A, B, E and F and Clostridium butyricum type E strains SO BMC BIOLOGY LA English DT Article ID SEROTYPE-A SUBTYPES; GENOME SEQUENCE; EVOLUTION; DATABASE; CLUSTERS; INTERRELATIONSHIPS; IDENTIFICATION; COMPONENT; ORGANISMS; PROTEINS AB Background: Clostridium botulinum is a taxonomic designation for at least four diverse species that are defined by the expression of one (monovalent) or two (bivalent) of seven different C. botulinum neurotoxins (BoNTs, A-G). The four species have been classified as C. botulinum Groups I-IV. The presence of bont genes in strains representing the different Groups is probably the result of horizontal transfer of the toxin operons between the species. Results: Chromosome and plasmid sequences of several C. botulinum strains representing A, B, E and F serotypes and a C. butyricum type E strain were compared to examine their genomic organization, or synteny, and the location of the botulinum toxin complex genes. These comparisons identified synteny among proteolytic (Group I) strains or nonproteolytic (Group II) strains but not between the two Groups. The bont complex genes within the strains examined were not randomly located but found within three regions of the chromosome or in two specific sites within plasmids. A comparison of sequences from a Bf strain revealed homology to the plasmid pCLJ with similar locations for the bont/bv b genes but with the bont/a4 gene replaced by the bont/f gene. An analysis of the toxin cluster genes showed that many recombination events have occurred, including several events within the ntnh gene. One such recombination event resulted in the integration of the bont/a1 gene into the serotype toxin B ha cluster, resulting in a successful lineage commonly associated with food borne botulism outbreaks. In C. botulinum type E and C. butyricum type E strains the location of the bont/e gene cluster appears to be the result of insertion events that split a rarA, recombination-associated gene, independently at the same location in both species. Conclusion: The analysis of the genomic sequences representing different strains reveals the presence of insertion sequence (IS) elements and other transposon-associated proteins such as recombinases that could facilitate the horizontal transfer of the bonts; these events, in addition to recombination among the toxin complex genes, have led to the lineages observed today within the neurotoxin-producing clostridia. C1 [Hill, Karen K.] Los Alamos Natl Lab, Biosci Div, Los Alamos, NM 87545 USA. [Xie, Gary; Munk, Amy C.; Bruce, David; Brettin, Thomas S.; Detter, John C.] Los Alamos Natl Lab, DOE Joint Genome Inst, Los Alamos, NM 87545 USA. [Foley, Brian T.] Los Alamos Natl Lab, Div Theoret, Los Alamos, NM 87545 USA. [Smith, Theresa J.; Smith, Leonard A.] USA, Med Inst Infect Dis USAMRIID, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. RP Hill, KK (reprint author), Los Alamos Natl Lab, Biosci Div, POB 1663, Los Alamos, NM 87545 USA. EM khill@lanl.gov; xie@lanl.gov; btf@lanl.gov; theresa.j.smith@us.army.mil; cmunk@lanl.gov; dbruce@lanl.gov; Leonard.a.Smith1@us.army.mil; brettints@ornl.gov; cdetter@lanl.gov OI Foley, Brian/0000-0002-1086-0296; xie, gary/0000-0002-9176-924X FU Department of Homeland Security Science and Technology Directorate [HSHQDC-08-C00158]; DOE Joint Genome Institute at Los Alamos National Laboratory; NIAID [U01 AI056493] FX This work was funded in part by the Department of Homeland Security Science and Technology Directorate under contract number HSHQDC-08-C00158. The DOE Joint Genome Institute at Los Alamos National Laboratory acknowledges the support of the Intelligence Technology Innovation Center for this research. This work was partially supported by NIAID cooperative agreement U01 AI056493. NR 47 TC 71 Z9 71 U1 1 U2 18 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1741-7007 J9 BMC BIOL JI BMC Biol. PD OCT 5 PY 2009 VL 7 AR 66 DI 10.1186/1741-7007-7-66 PG 18 WC Biology SC Life Sciences & Biomedicine - Other Topics GA 510CN UT WOS:000271065700001 PM 19804621 ER PT J AU Chisholm, CD Gentile, NT Gerhardt, RT Hauswald, M Mycyk, MB Sinert, R Sokolove, PE AF Chisholm, Carey D. Gentile, Nina T. Gerhardt, Robert T. Hauswald, Mark Mycyk, Mark B. Sinert, Richard Sokolove, Peter E. TI Medical Advertisements in Medical Journals: the Case Against SO ACADEMIC EMERGENCY MEDICINE LA English DT Editorial Material C1 [Chisholm, Carey D.] Indiana Univ, Sch Med, Dept Emergency Med, Indianapolis, IN 46204 USA. [Gentile, Nina T.] Temple Univ Hosp & Med Sch, Div Emergency Med, Philadelphia, PA 19140 USA. [Gerhardt, Robert T.] USA, Inst Surg Res, Brooke Army Med Ctr, San Antonio, TX USA. [Hauswald, Mark] Univ New Mexico, Dept Emergency Med, Albuquerque, NM 87131 USA. [Mycyk, Mark B.] Boston Univ, Boston, MA 02215 USA. [Sinert, Richard] SUNY, Brooklyn, NY USA. [Sokolove, Peter E.] Univ Calif Davis, Med Ctr, Dept Emergency Med, Sacramento, CA 95817 USA. RP Chisholm, CD (reprint author), Indiana Univ, Sch Med, Dept Emergency Med, Indianapolis, IN 46204 USA. NR 8 TC 2 Z9 2 U1 1 U2 1 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1069-6563 J9 ACAD EMERG MED JI Acad. Emerg. Med. PD OCT PY 2009 VL 16 IS 10 BP 981 EP 983 DI 10.1111/j.1553-2712.2009.00533.x PG 3 WC Emergency Medicine SC Emergency Medicine GA 501QP UT WOS:000270396700011 PM 19799575 ER PT J AU Fadare, O Rodriguez, R AF Fadare, Oluwole Rodriguez, Rosemarie TI The Significance of Marked Nuclear Atypia in Grade 1 Cervical Intraepithelial Neoplasia SO AMERICAN JOURNAL OF CLINICAL PATHOLOGY LA English DT Meeting Abstract CT AJCP Resident Research Symposium and Poster Sessions/Annual Meeting of the American-Society-for-Clinical-Pathology CY OCT 28-NOV 01, 2009 CL Chicago, IL SP Amer Soc Clin Pathol C1 [Fadare, Oluwole] Wilford Hall USAF Med Ctr, Dept Pathol, Lackland AFB, TX USA. [Fadare, Oluwole] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Rodriguez, Rosemarie] Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL PATHOLOGY PI CHICAGO PA 2100 W HARRISON ST, CHICAGO, IL 60612 USA SN 0002-9173 J9 AM J CLIN PATHOL JI Am. J. Clin. Pathol. PD OCT PY 2009 VL 132 IS 4 MA 26 BP 629 EP 630 PG 2 WC Pathology SC Pathology GA 503AQ UT WOS:000270503500043 ER PT J AU Acosta, R Norris, W Greenwald, B AF Acosta, Ruben Norris, William Greenwald, Bruce TI Long Term Placement of Self-expanding Plastic Stents is Safe for Benign Esophageal Disease SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 74th Annual Scientific Meeting and Postgraduate Course of the American-College-of-Gastroenterology CY OCT 23-28, 2009 CL San Diego, CA SP Amer Coll Gastroenterol C1 [Acosta, Ruben] Natl Naval Med Ctr, Bethesda, MD USA. [Norris, William] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Greenwald, Bruce] Univ Maryland, Baltimore, MD 21201 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2009 VL 104 SU 3 MA 83 BP S34 EP S34 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 507LA UT WOS:000270853600083 ER PT J AU Ainsworth, C Jones, F Fincher, K AF Ainsworth, Craig Jones, Frances Fincher, Keith TI Methemoglobinemia in Patients Undergoing Esophagogastroduodenoscopy SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 74th Annual Scientific Meeting and Postgraduate Course of the American-College-of-Gastroenterology CY OCT 23-28, 2009 CL San Diego, CA SP Amer Coll Gastroenterol C1 [Ainsworth, Craig; Jones, Frances; Fincher, Keith] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2009 VL 104 SU 3 MA 1349 BP S503 EP S504 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 507LA UT WOS:000270853601337 ER PT J AU Ally, M Betteridge, J Veerappan, G AF Ally, Mazer Betteridge, John Veerappan, Ganesh TI Delayed Hypersensitivity Reaction with Infliximab: Unusual to Occur after Initial Dose SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 74th Annual Scientific Meeting and Postgraduate Course of the American-College-of-Gastroenterology CY OCT 23-28, 2009 CL San Diego, CA SP Amer Coll Gastroenterol C1 [Ally, Mazer; Betteridge, John; Veerappan, Ganesh] Walter Reed Army Med Ctr, Gastroenterol Serv, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2009 VL 104 SU 3 MA 959 BP S353 EP S353 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 507LA UT WOS:000270853600949 ER PT J AU Furman, D Wong, R AF Furman, David Wong, Roy TI PET Marks the Spot: Incidental Finding of a Tubulovillous Adenoma on Positron Emission Tomography of a Lung Nodule SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 74th Annual Scientific Meeting and Postgraduate Course of the American-College-of-Gastroenterology CY OCT 23-28, 2009 CL San Diego, CA SP Amer Coll Gastroenterol C1 [Furman, David; Wong, Roy] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2009 VL 104 SU 3 MA 1085 BP S398 EP S398 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 507LA UT WOS:000270853601074 ER PT J AU Hjelkrem, M Pabby, A Fair, K AF Hjelkrem, Michael Pabby, Ajay Fair, Kevin TI Osseous Metaplasia in a Colorectal Neoplasia SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 74th Annual Scientific Meeting and Postgraduate Course of the American-College-of-Gastroenterology CY OCT 23-28, 2009 CL San Diego, CA SP Amer Coll Gastroenterol C1 [Hjelkrem, Michael] Brooke Army Med Ctr, San Antonio, TX USA. [Pabby, Ajay; Fair, Kevin] McDonald Army Hlth Ctr, Ft Eustis, VA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2009 VL 104 SU 3 MA 908 BP S335 EP S335 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 507LA UT WOS:000270853600898 ER PT J AU Jones, L Norris, W AF Jones, Lindsay Norris, William TI Rectal Burn Induced by a Hot Coffee Enema SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 74th Annual Scientific Meeting and Postgraduate Course of the American-College-of-Gastroenterology CY OCT 23-28, 2009 CL San Diego, CA SP Amer Coll Gastroenterol C1 [Jones, Lindsay] Natl Naval Med Ctr, Bethesda, MD USA. [Norris, William] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2009 VL 104 SU 3 MA 926 BP S341 EP S342 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 507LA UT WOS:000270853600916 ER PT J AU Kwok, R Betteridge, J Wong, R AF Kwok, Ryan Betteridge, John Wong, Roy TI Enterohemorrhagic Esherichia Coli Infection: An Atypical Presentation SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 74th Annual Scientific Meeting and Postgraduate Course of the American-College-of-Gastroenterology CY OCT 23-28, 2009 CL San Diego, CA SP Amer Coll Gastroenterol C1 [Kwok, Ryan; Betteridge, John; Wong, Roy] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2009 VL 104 SU 3 MA 769 BP S284 EP S285 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 507LA UT WOS:000270853600761 ER PT J AU Moawad, F Maydonovitch, C Cullen, P Barlow, D Jenson, D Cash, B AF Moawad, Fouad Maydonovitch, Corinne Cullen, Priscilla Barlow, Duncan Jenson, Donald Cash, Brooks TI Patients Prefer CT Colonography Over Colonoscopy SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 74th Annual Scientific Meeting and Postgraduate Course of the American-College-of-Gastroenterology CY OCT 23-28, 2009 CL San Diego, CA SP Amer Coll Gastroenterol C1 [Moawad, Fouad; Maydonovitch, Corinne] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Cullen, Priscilla; Barlow, Duncan; Jenson, Donald; Cash, Brooks] Natl Naval Med Ctr, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2009 VL 104 SU 3 MA 1494 BP S562 EP S562 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 507LA UT WOS:000270853601482 ER PT J AU Moawad, F Lake, J Maydonovitch, C Veerappan, G Bassett, J Wong, R AF Moawad, Fouad Lake, Jason Maydonovitch, Corinne Veerappan, Ganesh Bassett, John Wong, Roy TI Esophageal Motility Disorders are Uncommon in Eosinophilic Esophagitis SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 74th Annual Scientific Meeting and Postgraduate Course of the American-College-of-Gastroenterology CY OCT 23-28, 2009 CL San Diego, CA SP Amer Coll Gastroenterol C1 [Moawad, Fouad; Lake, Jason; Maydonovitch, Corinne; Veerappan, Ganesh; Bassett, John; Wong, Roy] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2009 VL 104 SU 3 MA 39 BP S16 EP S17 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 507LA UT WOS:000270853600040 ER PT J AU Papadopoulos, I Veerappan, G Horwhat, J AF Papadopoulos, Ioannis Veerappan, Ganesh Horwhat, John TI Cryotherapy for Palliation of Esophageal Adenocarcinoma SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 74th Annual Scientific Meeting and Postgraduate Course of the American-College-of-Gastroenterology CY OCT 23-28, 2009 CL San Diego, CA SP Amer Coll Gastroenterol C1 [Papadopoulos, Ioannis; Veerappan, Ganesh; Horwhat, John] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2009 VL 104 SU 3 MA 567 BP S212 EP S212 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 507LA UT WOS:000270853600561 ER PT J AU Ricker, J McNear, S Plott, E Cassidy, T Arnold, H Franklin, K AF Ricker, Jonathan McNear, Scott Plott, Eric Cassidy, Timothy Arnold, Hays Franklin, Kevin TI Routine Screening for Eosinophilic Esophagitis in Patients Presenting with Dysphagia SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 74th Annual Scientific Meeting and Postgraduate Course of the American-College-of-Gastroenterology CY OCT 23-28, 2009 CL San Diego, CA SP Amer Coll Gastroenterol C1 [Ricker, Jonathan; Plott, Eric; Cassidy, Timothy; Franklin, Kevin] Wilford Hall USAF Med Ctr, San Antonio, TX USA. [McNear, Scott; Arnold, Hays] Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2009 VL 104 SU 3 MA 22 BP S9 EP S9 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 507LA UT WOS:000270853600023 ER PT J AU Shrestha, M Cheatham, J Lake, J AF Shrestha, Merica Cheatham, Joseph Lake, Jason TI Esophagitis Dissecans Presenting as an Upper Esophageal Foreign Body Sensation SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 74th Annual Scientific Meeting and Postgraduate Course of the American-College-of-Gastroenterology CY OCT 23-28, 2009 CL San Diego, CA SP Amer Coll Gastroenterol C1 [Shrestha, Merica; Cheatham, Joseph; Lake, Jason] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2009 VL 104 SU 3 MA 551 BP S206 EP S207 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 507LA UT WOS:000270853600545 ER PT J AU Watson, J Sjogren, M AF Watson, Joshua Sjogren, Maria TI The Forgotten Hepatitis: Two Cases of Hepatitis E in Patients Returning from Operation Iraqi Freedom SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 74th Annual Scientific Meeting and Postgraduate Course of the American-College-of-Gastroenterology CY OCT 23-28, 2009 CL San Diego, CA SP Amer Coll Gastroenterol C1 [Watson, Joshua; Sjogren, Maria] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2009 VL 104 SU 3 MA 817 BP S302 EP S302 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 507LA UT WOS:000270853600808 ER PT J AU Taylor, DC DeBerardino, TM Nelson, BJ Duffey, M Tenuta, J Stoneman, PD Sturdivant, RX Mountcastle, S AF Taylor, Dean C. DeBerardino, Thomas M. Nelson, Bradley J. Duffey, Michele Tenuta, Joachim Stoneman, Paul D. Sturdivant, Rodney X. Mountcastle, Sally TI Patellar Tendon Versus Hamstring Tendon Autografts for Anterior Cruciate Ligament Reconstruction A Randomized Controlled Trial Using Similar Femoral and Tibial Fixation Methods SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE anterior cruciate ligament reconstruction; randomized controlled trial; ACL; hamstring autograft; patellar tendon autograft ID NUMERIC EVALUATION METHOD; FOLLOW-UP; GRACILIS TENDON; GRAFT FIXATION; INTERFERENCE SCREWS; ACL RECONSTRUCTION; SPECIAL EMPHASIS; KNEE PAIN; SEMITENDINOSUS; BONE AB Background: Controversy remains over the most appropriate graft for anterior cruciate ligament reconstruction. Hypothesis: There is no significant difference in outcomes after 4-strand hamstring and patellar tendon autograft anterior cruciate ligament reconstructions using similar fixation techniques. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: Between August 2000 and May 2003, 64 Keller Army Hospital patients with complete anterior cruciate ligament tears were randomized to hamstring (n = 32) or patellar tendon (n = 32) autograft anterior cruciate ligament reconstruction. Operative graft fixation and rehabilitative techniques were the same for both groups. Follow-up assessments included the Single Assessment Numeric Evaluation score, Lysholm score, International Knee Documentation Committee score, and Knee Injury and Osteoarthritis Outcome Score. Postoperative radiographs were analyzed for tunnel location and orientation. Results: Eleven women and 53 men were randomized. Eighty-three percent of the patients (53 of 64) had follow-up of greater than 2 years, or to the point of graft rupture or removal (average follow-up, 36 months). Four hamstring grafts (12.5%) and three patellar tendon grafts (9.4%) (P=.71) ruptured. One deep infection in a hamstring graft patient necessitated graft removal. Forty-five of the 56 patients with intact grafts had greater than 2-year follow-up. Patients with patellar tendon grafts had greater Tegner activity scores (P=.04). Single Assessment Numeric Evaluation scores were 88.5 (95% confidence interval: 83.1, 93.8) and 90.1 (95% confidence interval: 85.2, 96.1) for the hamstring and patellar tendon groups, respectively (P=.53). Lysholm scores were 90.3 (95% confidence interval: 84.4, 96.1) and 90.4 (95% confidence interval: 84.5, 96.3) for the hamstring and patellar tendon groups, respectively (P=.97). There were no significant differences in knee laxity, kneeling pain, isokinetic peak torque, International Knee Documentation Committee score, or Knee Injury and Osteoarthritis Outcome Scores. Postoperative graft rupture correlated with more horizontal tibial tunnel orientation. Conclusion: Hamstring and patellar tendon autografts provide similar objective, subjective, and functional outcomes when assessed at least 2 years after anterior cruciate ligament reconstruction. C1 [Taylor, Dean C.] Duke Univ, Med Ctr, Div Orthopaed Surg, Dept Surg, Durham, NC 27710 USA. [DeBerardino, Thomas M.; Tenuta, Joachim; Stoneman, Paul D.; Sturdivant, Rodney X.] US Mil Acad, West Point, NY 10996 USA. [DeBerardino, Thomas M.; Tenuta, Joachim; Stoneman, Paul D.; Sturdivant, Rodney X.] Keller Army Hosp, West Point, NY USA. [Nelson, Bradley J.] Univ Minnesota, TRIA Orthopaed Ctr, Minneapolis, MN USA. [Nelson, Bradley J.] Univ Minnesota, Dept Orthopaed Surg, Minneapolis, MN 55455 USA. [Duffey, Michele] Penn State Univ, University Pk, PA 16802 USA. [Mountcastle, Sally] Univ Kansas, Dept Prevent Med & Publ Hlth, Sch Med, Kansas City, KS USA. RP Taylor, DC (reprint author), Duke Univ, Med Ctr, Div Orthopaed Surg, Dept Surg, Box 3615, Durham, NC 27710 USA. EM dean.taylor@duke.edu OI DeBerardino, Thomas/0000-0002-7110-8743 NR 47 TC 45 Z9 49 U1 1 U2 8 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD OCT PY 2009 VL 37 IS 10 BP 1946 EP 1957 DI 10.1177/0363546509339577 PG 12 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 500BS UT WOS:000270272700007 PM 19684298 ER PT J AU Forster, CJ Cohee, BM Wood-Morris, RN Hartzell, JD AF Forster, Christopher J. Cohee, Brian M. Wood-Morris, Robert N. Hartzell, Joshua D. TI Nitrofurantoin-Induced Systemic Inflammatory Response Syndrome SO AMERICAN JOURNAL OF THE MEDICAL SCIENCES LA English DT Article DE Nitrofurantoin; Systemic inflammatory response syndrome; Adverse drug reaction; Fever; Leukocytosis ID ADVERSE REACTIONS; RESISTANCE; THERAPY; WOMEN; FEVER AB Nitrofurantoin is a commonly used antibiotic for the prophylaxis and treatment of urinary tract infections. We report the first case of nitrofurantoin-induced systemic inflammatory response syndrome, an important adverse drug reaction in the setting of what was initially believed to be a recurrent infection. C1 [Forster, Christopher J.] USA, Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. RP Forster, CJ (reprint author), USA, Walter Reed Army Med Ctr, Dept Med, Bldg 2,Ward 74,6900 Georgia Ave NW, Washington, DC 20307 USA. EM christopher.forster@amedd.army.mil NR 15 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0002-9629 J9 AM J MED SCI JI Am. J. Med. Sci. PD OCT PY 2009 VL 338 IS 4 BP 338 EP 340 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 511OE UT WOS:000271174300019 PM 19726971 ER PT J AU Obaldia, N Milhous, W Kyle, D AF Obaldia, Nicanor, III Milhous, Wilbur Kyle, Dennis TI Adaptation of a Thai Multidrug-Resistant C2A Clone of Plasmodium falciparum to Aotus Monkeys and Its Preliminary in vivo Antimalarial Drug Efficacy-Resistance Profile SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID PANAMANIAN OWL MONKEYS; LEMURINUS-GRISEIMEMBRA; CHLOROQUINE RESISTANCE; PROTECTIVE IMMUNITY; VOCIFERANS MONKEYS; DNA VACCINES; MALARIA; STRAIN; INFECTIONS; MEFLOQUINE AB A multidrug-resistant (MDR) clone of Plasmodium falciparum (C2A) from Thailand was adapted through serial passage to Aotus monkeys. During adaptation, the parasite showed resistance to a single 20 or 40 mg/kg oral close of mefloquine (MQ). Infection was only cured when MQ was administered orally at 40 mg/kg once in combination with intravenous artesunic acid at 20 mg/kg for 3 days. Similarly, the parasite clone was found to be resistant to quinine, failing at 20 mg/kg orally for 5 days in combination with an experimental dihydrofolate reductase (DHFR) inhibitor (WR297608) at 10, 20, or 40 mg/kg orally for 3 days, and with atovaquone/proguanil at 25 mg/kg for 3 days. This new model will allow in vivo testing of new antimalarial compounds or their combinations against a currently circulating MDR P. falciparum strain. C1 [Obaldia, Nicanor, III] Gorgas Mem Inst Hlth Studies, ICGES, Panama City, Panama. [Obaldia, Nicanor, III] Trop Med Res, Malaria Drug & Vaccine Evaluat Ctr, Panama City, Panama. [Milhous, Wilbur; Kyle, Dennis] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. Univ S Florida, Coll Publ Hlth, Dept Global Hlth, Tampa, FL 33612 USA. RP Obaldia, N (reprint author), Gorgas Mem Inst Hlth Studies, ICGES, Apdo 00816-02593, Panama City, Panama. EM nobaldia@gorgas.gob.pa RI Obaldia, Nicanor/O-8460-2015; OI Obaldia, Nicanor/0000-0002-3711-9449 FU USAMRDC [DAMD-17-96-C-6051, DAMD17-01-C0039, W81XWH-07-C-044] FX This work was supported by USAMRDC contracts no. DAMD-17-96-C-6051, DAMD17-01-C0039, and W81XWH-07-C-044. NR 50 TC 4 Z9 4 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 2009 VL 81 IS 4 BP 587 EP 594 DI 10.4269/ajtmh.2009.08-0445 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 502QC UT WOS:000270474000011 PM 19815871 ER PT J AU Li, QG Cantilena, LR Leary, KJ Saviolakis, GA Miller, RS Melendez, V Weina, PJ AF Li, Qigui Cantilena, Louis R. Leary, Kevin J. Saviolakis, George A. Miller, R. Scott Melendez, Victor Weina, Peter J. TI Pharmacokinetic Profiles of Artesunate After Single Intravenous Doses at 0.5, 1, 2, 4, and 8 mg/kg in Healthy Volunteers: A Phase I Study SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID SEVERE FALCIPARUM-MALARIA; DIHYDROARTEMISININ; RATS; ARTEMETHER; VALIDATION; ARTEETHER; EFFICACY; QUININE AB The pharmacokinetics of good manufacturing process injection of artesunate (AS) were evaluated after single closes at 0.5, 1, 2.4, and 8 mg/kg with a 2-minute infusion in 40 healthy subjects. Drug concentrations were analyzed by validated liquid chromatography and mass spectrometry system (LC-MS/MS) procedures. The drug was immediately converted to dihydroartemisinin (DHA), with elimination half-lives ranging 0.12-0.24 and 1.15-2.37 hours for AS and DHA. respectively. Pharmacokinetic model-dependent analysis is suitable for AS, whereas DHA fits both model-dependent and -independent methods. Although DHA concentration was superior to that of AS with a 1.12-1.87 ratio of area trader the curve (AUC)(DHA/AS), peak concentration of AS was much higher than that of DHA, with a 2.80- to 4.51-fold ratio of peak concentration (C(max AS/DHA)). Therefore,AS effectiveness has been attributed not only to its rapid hydrolysis to DHA, but also to itself high initial C(max). C1 [Li, Qigui; Cantilena, Louis R.; Leary, Kevin J.; Saviolakis, George A.; Miller, R. Scott; Melendez, Victor; Weina, Peter J.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Li, Qigui; Cantilena, Louis R.; Leary, Kevin J.; Saviolakis, George A.; Miller, R. Scott; Melendez, Victor; Weina, Peter J.] Uniformed Serv Univ Hlth Sci, Div Clin Pharmacol & Med Toxicol, Bethesda, MD 20814 USA. RP Li, QG (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM qigui.li@amedd.army.mil; lcantilena@usuhs.mil; kevin.leary@amedd.army.mil; george.saviolakis@amedd.army.mil; robert.miller@amedd.army.mil; victor.melendez@amedd.army.mil; peter.weina@amedd.army.mil RI Weina, Peter/A-2120-2011 FU US Army Research and Material Command FX This study was supported by the US Army Research and Material Command. NR 30 TC 18 Z9 18 U1 2 U2 8 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 2009 VL 81 IS 4 BP 615 EP 621 DI 10.4269/ajtmh.2009.09-0150 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 502QC UT WOS:000270474000016 PM 19815876 ER PT J AU Smith, DR Lee, JS Jahrling, J Kulesh, DA Turell, MJ Groebner, JL O'Guinn, ML AF Smith, Darci R. Lee, John S. Jahrling, Jordan Kulesh, David A. Turell, Michael J. Groebner, Jennifer L. O'Guinn, Monica L. TI Development of Field-Based Real-Time Reverse Transcription-Polymerase Chain Reaction Assays for Detection of Chikungunya and O'nyong-nyong Viruses in Mosquitoes SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID PCR ASSAY; FEVER; REEMERGENCE; QUANTIFICATION; DIAGNOSIS; EMERGENCE; ABSENCE; AFRICA; UGANDA; STEP AB Chikungunya (CHIK) and O'nyong-nyong (ONN) are important emerging arthropod-borne diseases. Molecular diagnosis of these two viruses in mosquitoes has not been evaluated, and the effects of extraneous mosquito tissue on assay performance have not been tested. Additionally, no real-time reverse transcription-polymerase chain reaction (RT-PCR) assay exists for detecting ONN virus (ONNV) RNA. We describe the development of sensitive and specific real-time RT-PCR assays for detecting CHIK and ONN viral RNA in mosquitoes, which have application for field use. In addition, we compared three methods for primer/probe design for assay development by evaluating their sensitivity and specificity. This comparison resulted in development of virus-specific assays that could detect less than one plaque-forming unit equivalent of each of the viruses in mosquitoes. The use of these assays will aid ill arthropod-borne disease surveillance and in the control of the associated diseases. C1 [O'Guinn, Monica L.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Jahrling, Jordan; Kulesh, David A.] USA, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. RP O'Guinn, ML (reprint author), USA, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA. EM darci.smith1@us.army.mil; john.s.lee@us.army.mil; jbjahrli@utmb.edu; david.kulesh@amedd.army.mil; michael.turell@amedd.army.mil; jennifer.groebner@amedd.army.mil; monica.oguinn@us.army.mil OI Groebner, Jennifer/0000-0003-1503-5030 FU Military Infectious Disease Research Program [U0176_09_RD] FX This study was supported by the Military Infectious Disease Research Program, Step U, project # U0176_09_RD. NR 26 TC 15 Z9 16 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 2009 VL 81 IS 4 BP 679 EP 684 DI 10.4269/ajtmh.2009.09-0138 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 502QC UT WOS:000270474000026 PM 19815886 ER PT J AU Kunz, AN Riera, D Hickey, P AF Kunz, Anjali N. Riera, Diana Hickey, Patrick TI Case of Clostridium perfringens bacteremia after routine colonoscopy and polypectomy SO ANAEROBE LA English DT Article DE Clostridium perfringens; Polypectomy; Bacteremia; Polymicrobial ID ANAEROBIC-BACTERIA AB Bacteremia is an uncommon complication after polypectomy and colonoscopy. We report one of the first cases of Clostridium perfringens bacteremia after polypectomy. Our patient was a four years old boy with congenital polyposis, who underwent colonoscopy and polypectomy without complication. Approximately 12 h later he developed a fever and tachycardia with no other clinical symptoms. His blood cultures grew out penicillin susceptible C perfringens and Enterococcus faecalis. He responded to antibiotic therapy and remained clinically asymptomatic for the duration of his course. There are a few reports of bacteremia after routine polypectomy, but no reported cases of C. perfringens bacteremia in the pediatric population. Clostridial sp. bacteremia can be fatal with devastating consequences if appropriate antibiotics and/or surgical debridement are delayed. Polymicrobial infection, as illustrated in our patient, is also common and can be a poor prognostic risk factor. Therefore, for patients with a history of polypectomy and new onset fever, anaerobic infections should be considered and empiric antibiotic therapy should include coverage for these organisms. Published by Elsevier Ltd. C1 [Kunz, Anjali N.; Riera, Diana; Hickey, Patrick] Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. RP Kunz, AN (reprint author), 5207 Elsmere Ave, Bethesda, MD 20814 USA. EM kdocs2002@verizon.net NR 7 TC 2 Z9 2 U1 0 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1075-9964 J9 ANAEROBE JI Anaerobe PD OCT PY 2009 VL 15 IS 5 BP 195 EP 196 DI 10.1016/j.anaerobe.2009.03.003 PG 2 WC Microbiology SC Microbiology GA 522MF UT WOS:000272001400002 PM 19324098 ER PT J AU Panchal, RG Ulrich, RL Lane, D Butler, MM Houseweart, C Opperman, T Williams, JD Peet, NP Moir, DT Nguyen, T Gussio, R Bowlin, T Bavari, S AF Panchal, Rekha G. Ulrich, Ricky L. Lane, Douglas Butler, Michelle M. Houseweart, Chad Opperman, Timothy Williams, John D. Peet, Norton P. Moir, Donald T. Nguyen, Tam Gussio, Rick Bowlin, Terry Bavari, Sina TI Novel Broad-Spectrum Bis-(Imidazolinylindole) Derivatives with Potent Antibacterial Activities against Antibiotic-Resistant Strains SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID DNA-BINDING LIGANDS; STAPHYLOCOCCUS-AUREUS; DIARYLAMIDINE DERIVATIVES; BACILLUS-ANTHRACIS; IN-VITRO; SUSCEPTIBILITY; LETHAL AB Given the limited number of structural classes of clinically available antimicrobial drugs, the discovery of antibacterials with novel chemical scaffolds is an important strategy in the development of effective therapeutics for both naturally occurring and engineered resistant strains of pathogenic bacteria. In this study, several diarylamidine derivatives were evaluated for their ability to protect macrophages from cell death following infection with Bacillus anthracis, a gram-positive spore-forming bacterium. Four bis-(imidazolinylindole) compounds were identified with potent antibacterial activity as measured by the protection of macrophages and by the inhibition of bacterial growth in vitro. These compounds were effective against a broad range of gram-positive and gram-negative bacterial species, including several antibiotic-resistant strains. Minor structural variations among the four compounds correlated with differences in their effects on bacterial macromolecular synthesis and mechanisms of resistance. In vivo studies revealed protection by two of the compounds of mice lethally infected with B. anthracis, Staphylococcus aureus, or Yersinia pestis. Taken together, these results indicate that the bis-(imidazolinylindole) compounds represent a new chemotype for the development of therapeutics for both gram-positive and gram-negative bacterial species as well as against antibiotic-resistant infections. C1 [Panchal, Rekha G.; Ulrich, Ricky L.; Bavari, Sina] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Lane, Douglas; Nguyen, Tam] NCI, Target Struct Based Drug Discovery Grp, SAIC Frederick Inc, Frederick, MD 21702 USA. [Butler, Michelle M.; Houseweart, Chad; Opperman, Timothy; Williams, John D.; Peet, Norton P.; Moir, Donald T.; Bowlin, Terry] Microbiotix Inc, Worcester, MA 01605 USA. [Gussio, Rick] NCI, Target Struct Based Drug Discovery Grp, Informat Technol Branch, Dev Therapeut Program, Frederick, MD 21702 USA. RP Panchal, RG (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM rekha.panchal@amedd.army.mil; sina.bavari@amedd.army.mil FU NCI NIH HHS [N01-CO-12400, N01CO12400] NR 25 TC 25 Z9 26 U1 1 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD OCT PY 2009 VL 53 IS 10 BP 4283 EP 4291 DI 10.1128/AAC.01709-08 PG 9 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 496ZS UT WOS:000270020600032 PM 19635954 ER PT J AU Korakianitis, T Boruta, M Jerovsek, J Meitner, PL AF Korakianitis, T. Boruta, M. Jerovsek, J. Meitner, P. L. TI Performance of a single nutating disk engine in the 2 to 500 kW power range SO APPLIED ENERGY LA English DT Article DE Advanced power generation; Novel engine; Nutating disk; Engine performance; High thermal efficiency; Low fuel consumption; Power; Power density AB A new type of internal combustion engine with distinct advantages over conventional piston-engines and gas turbines in small power ranges is presented. The engine has analogies with piston engine operation, but like gas turbines it has dedicated spaces and devices for compression, burning and expansion. The engine operates on a modified limited-pressure thermodynamic cycle. The core of the engine is a nutating non-rotating disk, with the center of its hub mounted in the middle of a Z-shaped shaft. The two ends of the shaft rotate, while the disk nutates. The motion of the disk circumference prescribes a portion of a sphere. In the single-disk configuration a portion of the surface area of the disk is used for intake and compression, a portion is used to seal against a center casing, and the remaining portion is used for expansion and exhaust. The compressed air is admitted to an external accumulator, and then into an external combustion chamber before it is admitted to the power side of the disk. The external combustion chamber enables the engine to operate on a variable compression ratio cycle. Variations in cycle temperature ratio and compression ratio during normal operation enable the engine to effectively become a variable-cycle engine, allowing significant flexibility for optimizing efficiency or power output. The thermal efficiency is similar to that of medium sized diesel engines. For the same engine volume and weight this engine produces approximately twice the power of a two-stroke engine and four times the power of a four-stroke engine. The computed sea-level engine performance at design and off-design conditions in the 2 to 500 kW power range is presented. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Korakianitis, T.] Univ London, Sch Mat Sci & Engn, London, England. [Boruta, M.; Jerovsek, J.] Kinet BEI LLC, S Elgin, IL USA. [Meitner, P. L.] USA, Res Lab, Glenn Res Ctr, Cleveland, OH USA. RP Korakianitis, T (reprint author), Univ London, Sch Mat Sci & Engn, London, England. EM theodosios@alum.mit.edu NR 23 TC 11 Z9 11 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0306-2619 EI 1872-9118 J9 APPL ENERG JI Appl. Energy PD OCT PY 2009 VL 86 IS 10 BP 2213 EP 2221 DI 10.1016/j.apenergy.2009.01.006 PG 9 WC Energy & Fuels; Engineering, Chemical SC Energy & Fuels; Engineering GA 446NU UT WOS:000266129100042 ER PT J AU Edmonds, JM AF Edmonds, Jason M. TI Efficient methods for large-area surface sampling of sites contaminated with pathogenic microorganisms and other hazardous agents: current state, needs, and perspectives SO APPLIED MICROBIOLOGY AND BIOTECHNOLOGY LA English DT Review DE Surface; Sampling; Toxin; Spores; Anthrax; Large area ID BACILLUS-ANTHRACIS SPORES; NONPOROUS SURFACES; RECOVERY; COLLECTION AB The recovery operations following the 2001 attacks with Bacillus anthracis spores were complicated due to the unprecedented need for large-area surface sampling and decontamination protocols. Since this event, multiple reports have been published describing recovery efficiencies of several surface sampling materials. These materials include fibrous swabs of various compositions, cloth wipes, vacuum socks, and adhesive tapes. These materials have reported recovery efficiencies ranging from approximately 20% to 90% due to the many variations in their respective studies including sampling material, composition of surface sampled, concentration of contaminant, and even the method of deposition and sample processing. Additionally, the term recovery efficiency is crudely defined and could be better constructed to incorporate variations in contaminated surface composition and end user needs. While significant efforts in devising protocols for large-area surface sampling have been undertaken in the years since the anthrax attacks, there is still a general lack of consensus in optimal sampling materials and the methodology in which they are evaluated. Fortunately, sampling efforts are continuing to be supported, and the knowledge gaps in our procedures, methodology, and general understanding of sampling mechanisms are being investigated which will leave us better prepared for the future. C1 USA, Edgewood Chem Biol Ctr, Dept Def, APGEA, Aberdeen Proving Ground, MD 21010 USA. RP Edmonds, JM (reprint author), USA, Edgewood Chem Biol Ctr, Dept Def, APGEA, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM Jason.Edmonds1@us.army.mil RI Robertson, Simon/D-1549-2012 NR 13 TC 24 Z9 24 U1 0 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0175-7598 J9 APPL MICROBIOL BIOT JI Appl. Microbiol. Biotechnol. PD OCT PY 2009 VL 84 IS 5 BP 811 EP 816 DI 10.1007/s00253-009-2136-z PG 6 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 494UM UT WOS:000269844000002 PM 19644689 ER PT J AU Carpenter, KM Andersen, BL Fowler, JM Maxwell, GL AF Carpenter, Kristen M. Andersen, Barbara L. Fowler, Jeffrey M. Maxwell, G. Larry TI Sexual Self Schema as a Moderator of Sexual and Psychological Outcomes for Gynecologic Cancer Survivors SO ARCHIVES OF SEXUAL BEHAVIOR LA English DT Article DE Schema; Sexual dysfunction; Gynecologic cancer; Depression; Quality of life ID QUALITY-OF-LIFE; FUNCTION INDEX FSFI; EARLY-STAGE BREAST; BODY CHANGE STRESS; CERVICAL-CANCER; OVARIAN-CANCER; FUNCTIONAL ASSESSMENT; DEPRESSIVE SYMPTOMS; PROSTATE CARCINOMA; AFRICAN-AMERICAN AB Gynecologic cancer patients are at high risk for emotional distress and sexual dysfunction. The present study tested sexual self schema as an individual difference variable that might be useful in identifying those at risk for unfavorable outcomes. First, we tested schema as a predictor of sexual outcomes, including body change stress. Second, we examined schema as a contributor to broader quality of life outcomes, specifically as a moderator of the relationship between sexual satisfaction and psychological statue (depressive symptoms and quality of life). A cross-sectional design was used. Gynecologic cancer survivors (N = 175) 2-10 years post treatment were assessed during routine follow up. In regression analyses controlling for sociodemographic variables, patients' physical symptoms/signs as evaluated by nurses, health status, and extent of partner sexual difficulties, sexual self schema accounted for significant variance in the prediction of current sexual behavior, responsiveness, and satisfaction. Moreover, schema moderated the relationship between sexual satisfaction and psychological outcomes, suggesting that a positive sexual self schema might "buffer" patients from depressive symptoms when their sexual satisfaction is low. Furthermore, the combination of a negative sexual self schema and low sexual satisfaction might heighten survivors' risk for psychological distress, including depressive symptomatology. These data support the consideration of sexual self schema as a predictor of sexual morbidity among gynecologic cancer survivors. C1 [Carpenter, Kristen M.] Univ Calif Los Angeles, Div Canc Prevent & Control Res, Los Angeles, CA 90095 USA. [Andersen, Barbara L.] Ohio State Univ, Dept Psychol, Ctr Comprehens Canc, Columbus, OH 43210 USA. [Fowler, Jeffrey M.] Ohio State Univ, Dept Obstet & Gynecol, Ctr Comprehens Canc, Div Gynecol Oncol,Coll Med, Columbus, OH 43210 USA. [Maxwell, G. Larry] Walter Reed Army Med Ctr, US Mil Canc Inst, Gynecol Dis Ctr, Washington, DC 20307 USA. RP Carpenter, KM (reprint author), Univ Calif Los Angeles, Div Canc Prevent & Control Res, 650 Charles Young Dr S,A2-125,Box 956900, Los Angeles, CA 90095 USA. EM kcarpenter@ucla.edu RI Carpenter, Kristen/I-1569-2013 FU NCI NIH HHS [K05 CA098133, K05 CA098133-04, K05 CA098133-05, R01 CA092704, R01 CA092704-08, R01CA92704] NR 98 TC 28 Z9 28 U1 3 U2 10 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0004-0002 J9 ARCH SEX BEHAV JI Arch. Sex. Behav. PD OCT PY 2009 VL 38 IS 5 BP 828 EP 841 DI 10.1007/s10508-008-9349-6 PG 14 WC Psychology, Clinical; Social Sciences, Interdisciplinary SC Psychology; Social Sciences - Other Topics GA 495HX UT WOS:000269882800024 PM 18418707 ER PT J AU Reed, GE Bullis, RC AF Reed, George E. Bullis, R. Craig TI The Impact of Destructive Leadership on Senior Military Officers and Civilian Employees SO ARMED FORCES & SOCIETY LA English DT Article DE leadership; petty tyranny; satisfaction; retention ID ABUSIVE SUPERVISION AB This article examines negative or destructive leadership behaviors experienced by high-potential senior military officers and civilian employees. The study used a questionnaire based on the Petty Tyranny in Organizations Scale to explore the scope and nature of destructive leadership as reported by U.S. members of the class of 2008 at a military senior service college. It also explored the relationship between leadership experiences and various measures of satisfaction and inclination to remain in service. The authors observe that despite the central role that the concept of leadership holds in the military, even senior personnel reported experiencing toxic leadership. There was a significant negative relationship between destructive leadership and all measures of satisfaction. Surprisingly, there was not a significant negative impact on inclination to remain in service among this career-oriented and dedicated population. C1 [Reed, George E.] Univ San Diego, Sch Leadership & Educ Sci, Dept Leadership Studies, San Diego, CA 92110 USA. [Bullis, R. Craig] USA, War Coll, Army Phys Fitness Res Inst, Washington, DC USA. RP Reed, GE (reprint author), Univ San Diego, Sch Leadership & Educ Sci, Dept Leadership Studies, 5998 Alcala Pk, San Diego, CA 92110 USA. EM george.reed@sandiego.edu; richard.bullis@us.army.mil NR 20 TC 8 Z9 8 U1 3 U2 15 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD OCT PY 2009 VL 36 IS 1 BP 5 EP 18 DI 10.1177/0095327X09334994 PG 14 WC Political Science; Sociology SC Government & Law; Sociology GA 496TK UT WOS:000270001300001 ER PT J AU Griffith, J AF Griffith, James TI Being a Reserve Soldier A Matter of Social Identity SO ARMED FORCES & SOCIETY LA English DT Review DE reserve military service; social identity; reservist identity; readiness; retention ID ARMY-NATIONAL-GUARD; ISRAELI SOLDIERS; ORGANIZATIONAL CONTEXTS; GROUP COHESION; ROLE AMBIGUITY; ROLE-CONFLICT; MILITARY; RETENTION; PERFORMANCE; COMBAT AB Drawing on social identity theory, the present article examines the extent to which soldier identification with the small unit is related to outcomes having increased importance to reserve military service. Measures of social identity have stronger associations with unit membership, whereas measures of personal identity do not. Soldiers' reports of positive experiences when first entering the unit are more strongly and positively related to measures of social identity than to measures of personal identity. Measures of social identity show positive relationships with group-relevant outcomes, such as commitment to the unit and perceived readiness of the unit and fellow soldiers. Measures of personal identity show positive relationships with individually relevant outcomes, such as reporting for duty for contractual reasons and letting their families down and perceived personal readiness for combat. Results imply improving specific small-unit relations and developing abstract beliefs to increase reservists' perceived readiness and commitment to their part-time military service. C1 [Griffith, James] USA, Washington, DC USA. RP Griffith, J (reprint author), 10956 Bellehaven Blvd, Damascus, MD 20872 USA. EM GriffithJH@verizon.net NR 99 TC 10 Z9 10 U1 1 U2 9 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0095-327X EI 1556-0848 J9 ARMED FORCES SOC JI Armed Forces Soc. PD OCT PY 2009 VL 36 IS 1 BP 38 EP 64 DI 10.1177/0095327X08327819 PG 27 WC Political Science; Sociology SC Government & Law; Sociology GA 496TK UT WOS:000270001300003 ER PT J AU Burnett, JC Wang, C Nuss, JE Nguyen, TL Hermone, AR Schmidt, JJ Gussio, R Wipf, P Bavari, S AF Burnett, J. C. Wang, C. Nuss, J. E. Nguyen, T. L. Hermone, A. R. Schmidt, J. J. Gussio, R. Wipf, P. Bavari, S. TI Pharmacophore-guided lead optimization: The rational design of a non-zinc coordinating, sub-micromolar inhibitor of the botulinum neurotoxin serotype a metalloprotease SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS LA English DT Article DE Inhibitor design; Inhibitor synthesis; Botulinum neurotoxin; Metalloprotease; Biothreat agent; Pharmacophore; Drug design ID SMALL-MOLECULE INHIBITORS; NEUROTRANSMITTER RELEASE; PROTEASE INHIBITORS; IDENTIFICATION; ENDOPEPTIDASE; TOXIN; VAMP/SYNAPTOBREVIN; PROTEOLYSIS; TETANUS; SNAP-25 AB Botulinum neurotoxins, responsible for the neuroparalytic syndrome botulism, are the deadliest of known biological toxins. The work described in this study was based on a three-zone pharmacophore model for botulinum neurotoxin serotype A light chain inhibition. Specifically, the pharmacophore defined a separation between the overlaps of several different, non-zinc(II)-coordinating small molecule chemotypes, enabling the design and synthesis of a new structural hybrid possessing a K(i) = 600 nM (+/- 100 nM). (C) 2009 Published by Elsevier Ltd. C1 [Burnett, J. C.; Nguyen, T. L.; Hermone, A. R.] NCI, SAIC Frederick Inc, Target Struct Based Drug Discovery Grp, Frederick, MD 21702 USA. [Wang, C.; Wipf, P.] Univ Pittsburgh, Combinatorial Chem Ctr, Pittsburgh, PA 15260 USA. [Nuss, J. E.; Bavari, S.] USA, Med Res Inst Infect Dis, Dept Immunol Target Identificat & Translat Res, Div Bacteriol, Frederick, MD 21702 USA. [Schmidt, J. J.] USA, Med Res Inst Infect Dis, Dept Cell Biol & Biochem, Div Biochem, Frederick, MD 21702 USA. [Gussio, R.] NCI, Informat Technol Branch, Dev Therapeut Program, Frederick, MD 21702 USA. RP Burnett, JC (reprint author), NCI, SAIC Frederick Inc, Target Struct Based Drug Discovery Grp, POB B, Frederick, MD 21702 USA. EM burnett.james@mail.nih.gov; pwipf@pitt.edu; sina.bavari@us.army.mil FU Defense Threat Reduction Agency [3.10024_06_RD_B]; MRMC and NCI, National Institutes of Health [Y3CM 100505, N01-CO-12400]; Developmental Therapeutics Program in the Division of Cancer Treatment and Diagnosis of the National Cancer Institute FX This research was funded by Defense Threat Reduction Agency project 3.10024_06_RD_B and Agreement Y3CM 100505 ( MRMC and NCI, National Institutes of Health). Additionally, this project has been funded in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health, under contract N01-CO-12400. The content of this publication does not necessarily reflect that views or policies of the Department of Health and Human Services or the U. S. Army, nor does mention of trade names, commercial products, or organizations imply endorsement by the U. S. Army or the U. S. Government. This research was supported [ in part] by the Developmental Therapeutics Program in the Division of Cancer Treatment and Diagnosis of the National Cancer Institute. NR 34 TC 32 Z9 32 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0960-894X J9 BIOORG MED CHEM LETT JI Bioorg. Med. Chem. Lett. PD OCT 1 PY 2009 VL 19 IS 19 BP 5811 EP 5813 DI 10.1016/j.bmcl.2009.01.111 PG 3 WC Chemistry, Medicinal; Chemistry, Organic SC Pharmacology & Pharmacy; Chemistry GA 498AH UT WOS:000270106700065 PM 19703771 ER PT J AU Hebert, CG Valdes, JJ Bentley, WE AF Hebert, Colin G. Valdes, James J. Bentley, William E. TI In Vitro and In Vivo RNA Interference Mediated Suppression of Tn-Caspase-1 for Improved Recombinant Protein Production in High Five (TM) Cell Culture With the Baculovirus Expression Vector System SO BIOTECHNOLOGY AND BIOENGINEERING LA English DT Article DE RNA interference; RNAi; High Five (TM); metabolic engineering; Baculovirus Expression Vector System; BEVS ID HAMSTER OVARY CELLS; GREEN FLUORESCENT PROTEIN; DOUBLE-STRANDED-RNA; SF-9 INSECT CELLS; DISULFIDE-ISOMERASE; ANTIBODY SECRETION; DOWN-REGULATION; BATCH CULTURES; CHO-CELLS; APOPTOSIS AB While traditional metabolic engineering generally relies on the augmentation of specific genes and pathways in order to increase the yield of target proteins, the advent of RNA interference (RNAi) as a biological tool has given metabolic engineers another tool capable of rationally altering the host cell's biological landscape in order to achieve a specific goal. Given its broad applicability and potent specificity, RNAi has the ability to suppress genes whose function is contrary to the desired phenotype. In this study, RNAi has been used to increase recombinant protein production in a Trichoplusia ni derived cell line (BTI-TN-5B1-4-High Five (TM)) using the Baculovirus Expression Vector System. The specific target investigated is Tn-caspase-1, a protease involved in apoptosis that is likely the principal effector caspase present in T. ni cells. Experiments were first conducted using in vitro synthesized dsRNA to verify silencing of Tn-capase-1 and increased protein production as a result. Subsequent experiments were conducted using a cell line stably expressing in vivo RNAi in the form of an inverted repeat that results in a hairpin upon transcription. Using this construct, Tn-caspase-1 transcript levels were decreased by 50% and caspase enzymatic activity was decreased by 90%. This cell line, designated dsTncasp-2, demonstrates superior viability under low nutrient culture conditions and resulted in as much as two times the Protein yield when compared to standard High Five cells. Biotechnol. Bioeng. 2009;104: 390-399. (C) 2009 Wiley Periodicals, Inc. C1 [Hebert, Colin G.; Bentley, William E.] Univ Maryland, Inst Biotechnol, Ctr Biosyst Res, College Pk, MD 20742 USA. [Hebert, Colin G.; Valdes, James J.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. [Hebert, Colin G.; Bentley, William E.] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA. [Bentley, William E.] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. RP Bentley, WE (reprint author), Univ Maryland, Inst Biotechnol, Ctr Biosyst Res, 5115 Plant Sci Bldg, College Pk, MD 20742 USA. EM bentley@eng.umd.edu FU United States Department of Defense; National Institutes of Health [GM70851-01] FX Partial Support of this work was provided by the United States Department of Defense (CREST Fellowship) and the National Institutes of Health (GM70851-01). NR 52 TC 7 Z9 7 U1 1 U2 5 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0006-3592 J9 BIOTECHNOL BIOENG JI Biotechnol. Bioeng. PD OCT 1 PY 2009 VL 104 IS 2 BP 390 EP 399 DI 10.1002/bit.22411 PG 10 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 494VI UT WOS:000269846900017 PM 19557836 ER PT J AU Li, QG Si, Y Xie, L Zhang, J Weina, P AF Li, Qigui Si, Yuanzheng Xie, Lisa Zhang, Jing Weina, Peter TI Severe Embryolethality of Artesunate Related to Pharmacokinetics Following Intravenous and Intramuscular Doses in Pregnant Rats SO BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY LA English DT Article DE embryolethality; artesunate; pharmacokinetics; pregnant rats ID UNCOMPLICATED FALCIPARUM-MALARIA; DRUG DIHYDROARTEMISININ DHA; DEVELOPMENTAL TOXICITY; TISSUE DISTRIBUTION; IN-VITRO; EMBRYOTOXICITY; ARTEMETHER; TOXICOKINETICS; ANGIOGENESIS; ARTEMISININ AB Artesunate (AS), a rapid, effective, and safe antimalarial drug, has been used for the treatment of malaria for decades However, severe embryolethality was found for injectable AS in pregnant animals In the present study, Pregnant rats were selected and closed with AS (GMP product) intravenously (IV) and intramuscularly (IM) at varied doses daily for 13 days from gestation day (GD) 6 to 18. In addition, a toxic dose of 1.2 mg/kg/day was subsequently tested in the GD 6-10, GD 11-15, and GD 16-20 periods of rat pregnancy A pharmacokinetic Study was also conducted to evaluate the bioavailability of AS following the IM. administrations. Results showed that no significant adverse effects were found in maternal rate All of the fetuses were either damaged or reabsorbed by placentas in treated Pregnant rats, but doses did not show an adverse effect at 0 4 and 0 5 mg/kg after Wand IM administrations, respectively. The Survival fate of fetuses is dose-dependent and the 50% fetus re-absorption doses (FRD(50)) were 0 61 and 0 60 mg/kg following the IV and IM, respectively. The most drug-sensitive period, showing severe embryotoxicity, was between GD 11 and 15 for injectable AS. When Calculated with total concentrations of AS and dihydroartemisinin, in active metabolite of AS, the bioavailability of 97 8% after intramuscular injection was fulfilled to a bioequivalence of that in intravenous treatment The fact that injectable AS exhibited severe embryolethality after both IV and IM injections seems related to their comparable pharmacokinetic profiles that indicate high peak concentrations in Pregnant animals. Birth Defects Res (Part B) 86 385-393, 2009 Published 2009 Wiley-Liss, Inc C1 [Li, Qigui; Si, Yuanzheng; Xie, Lisa; Zhang, Jing; Weina, Peter] Walter Reed Army Inst Res, Dept Pharmacol, Div Expt Therapeut, Silver Spring, MD 20307 USA. RP Li, QG (reprint author), Walter Reed Army Inst Res, Dept Pharmacol, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20307 USA. RI Weina, Peter/A-2120-2011 FU United States Army Research and Materiel Command FX Grant sponsor United States Army Research and Materiel Command NR 41 TC 6 Z9 6 U1 0 U2 2 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1542-9733 J9 BIRTH DEFECTS RES B JI Birth Defects Res. Part B-Dev. Reprod. Toxicol. PD OCT PY 2009 VL 86 IS 5 BP 385 EP 393 DI 10.1002/bdrb.20207 PG 9 WC Oncology; Genetics & Heredity; Toxicology SC Oncology; Genetics & Heredity; Toxicology GA 516QN UT WOS:000271557500005 PM 19851989 ER PT J AU Lester, ME Urso, ML Evans, RK Pierce, JR Spiering, BA Maresh, CM Hatfield, DL Kraemer, WJ Nindl, BC AF Lester, Mark E. Urso, Maria L. Evans, Rachel K. Pierce, Joseph R. Spiering, Barry A. Maresh, Carl M. Hatfield, Disa L. Kraemer, William J. Nindl, Bradley C. TI Influence of exercise mode and osteogenic index on bone biomarker responses during short-term physical training SO BONE LA English DT Article DE Exercise; Bone turnover; pQCT; DXA; Osteogenic index ID MINERAL DENSITY; REMODELING TRANSIENT; POSTMENOPAUSAL WOMEN; WEIGHT-BEARING; TURNOVER; MASS; MEN; INTENSITY; MARKERS; WALKING AB Prescribing exercise based oil intensity, frequency, and duration of loading may maximize osteogenic responses in bone, but a model of the osteogenic potential of exercise has not been established in humans In. rodents, an osteogenic index (OI) has been used to predict the osteogenic potential of exercise. The current study Sought to determine whether aerobic, resistance, or combined aerobic and resistance exercise programs conducted over eight weeks and compared to a control group could produce changes in biochemical markers of bone turnover indicative of bone formation. We further sought to determine whether an 01 could be calculated for each of these programs that would reflect observed biochemical changes. We collected serum biomarkers [bone-specific alkaline phosphatase (BAP), osteocalcin, tartrate-resistant acid phosphatase (TRAP), C-terminal telopeptide fragment of type I collagen (CTx) deoxypyridinoline (DPD), 25-hydroxy vitamin D (25(OH)D), and parathyroid hormone (PTH)] in 56 women (20.3 +/- 1.8 years) before, during and after eight weeks of training. We also measured bone mineral density (BMD) at regional areas of interest using DXA and pQCT. Biomarkers of bone formation (BAP and osteocalcin) increased in the Resistance and Combined groups (p<0.05), while biomarkers of bone resorption (TRAP and DPD) decreased and increased, respectively, after training (p<0.05) in all groups. Small changes in volumetric and areal BMD (p<0.05) were observed in the distal tibia in the Aerobic and Combined groups, respectively. Mean weekly OIs were 16.0 +/- 1.9, 20.6 +/- 2.2, and 36.9 +/- 5.2 for the Resistance, Aerobic, and Combined groups, respectively. The Calculated osteogenic potential of our programs did not correlate with the observed changes in biomarkers of bone turnover. The results of the present study demonstrate that Participation in an eight week physical training program that incorporates a resistance component by previously inactive young women results in alterations in biomarkers of bone remodeling indicative of increased formation without substantial alterations in markers of resorption. Published by Elsevier Inc. C1 [Lester, Mark E.; Urso, Maria L.; Evans, Rachel K.; Pierce, Joseph R.; Nindl, Bradley C.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Spiering, Barry A.; Maresh, Carl M.; Hatfield, Disa L.; Kraemer, William J.] Univ Connecticut, Dept Kinesiol, Storrs, CT 06269 USA. RP Nindl, BC (reprint author), USA, Environm Med Res Inst, Mil Performance Div, Bldg 42,Kansas St, Natick, MA 01760 USA. EM bradley.nindl@us.army.mil OI Urso, Maria/0000-0001-8906-4673 FU US Army Medical Research FX The authors thank Heath Isome and Daniel Catrambone for their assistance in data collection and analysis, as well as the Volunteers from the University of Connecticut for their time and dedication. This research was supported by a grant from the US Army Medical Research and Materiel Command Bone Health and Military Medical Readiness Research Program to BCN. NR 38 TC 46 Z9 48 U1 0 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 8756-3282 EI 1873-2763 J9 BONE JI Bone PD OCT PY 2009 VL 45 IS 4 BP 768 EP 776 DI 10.1016/j.bone.2009.06.001 PG 9 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 499GA UT WOS:000270204700019 PM 19520194 ER PT J AU Galson, S AF Galson, Steven TI Opening Keynote Remarks to the First Breastfeeding Summit SO BREASTFEEDING MEDICINE LA English DT Editorial Material C1 [Galson, Steven] US Dept HHS, Washington, DC 20201 USA. [Galson, Steven] USA, Washington, DC 20310 USA. RP Galson, S (reprint author), US Dept HHS, 200 Independence Ave SW, Washington, DC 20201 USA. EM tomas.bonome@hhs.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1556-8253 J9 BREASTFEED MED JI Breastfeed. Med. PD OCT PY 2009 VL 4 SU 1 BP S5 EP S7 DI 10.1089/bfm.2009.0040 PG 3 WC Obstetrics & Gynecology; Pediatrics SC Obstetrics & Gynecology; Pediatrics GA 585AW UT WOS:000276797700003 PM 19827924 ER PT J AU Palmer, JC Brennan, JK Hurley, MM Balboa, A Gubbins, KE AF Palmer, J. C. Brennan, J. K. Hurley, M. M. Balboa, A. Gubbins, K. E. TI Detailed structural models for activated carbons from molecular simulation SO CARBON LA English DT Article ID REVERSE MONTE-CARLO; SIZE DISTRIBUTION ANALYSIS; MICROPOROUS CARBONS; SELECTIVE OXIDATION; METHYLENE-CHLORIDE; POROUS GLASSES; ADSORPTION; SURFACE; METHANE; NANOPORES AB A detailed atomistic model of Calgon Co.'s bituminous coal-based activated carbon (BPL) was developed using an adaptation of the Hybrid Reverse Monte Carlo method. The resulting model was a highly heterogeneous carbon structure that had features consistent with experimental X-ray diffraction measurements. The microstructure of the model was characterized and Grand Canonical Monte Carlo simulations were used to examine the adsorptive properties of the model. These findings were compared with experimental measurements taken on samples of the real material. The results showed that the model provides a realistic description of the BPL's microstructure and accurately predicts adsorptive behavior over a wide range of state conditions. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Palmer, J. C.; Gubbins, K. E.] N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA. [Brennan, J. K.; Hurley, M. M.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Balboa, A.] USA, Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA. RP Palmer, JC (reprint author), N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA. EM jcpalmer@ncsu.edu FU US Defense Threat Reduction Agency [AA07CBT011] FX This work was supported by the US Defense Threat Reduction Agency (Project ID: AA07CBT011). We also acknowledge Prof Teresa Bandosz (CUNY), Rick Beyer (US Army Research Laboratory) and Nathalie Cohaut (CRMD, Orleans) for their assistance in experimental data collection and analysis and for helpful discussions. NR 51 TC 48 Z9 50 U1 7 U2 35 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0008-6223 J9 CARBON JI Carbon PD OCT PY 2009 VL 47 IS 12 BP 2904 EP 2913 DI 10.1016/j.carbon.2009.06.037 PG 10 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 489OT UT WOS:000269430600017 ER PT J AU Uchimiya, M Stone, AT AF Uchimiya, Minori Stone, Alan T. TI Reversible redox chemistry of quinones: Impact on biogeochemical cycles SO CHEMOSPHERE LA English DT Review DE Benzoquinone; Hydroquinone; Catechol; Semiquinone radical; Electron shuttle; Natural organic matter ID NATURAL ORGANIC-MATTER; EXTRACELLULAR ELECTRON-TRANSFER; HUMIC SUBSTANCES; IRON(III) REDUCTION; SUBSTITUTED SEMIQUINONES; NITROAROMATIC COMPOUNDS; SUPEROXIDE-DISMUTASE; CARBON-TETRACHLORIDE; ANODIC HYDROXYLATION; ABIOTIC REDUCTION AB The role of quinone biomolecules and quinone moieties of natural organic matter (NOM) as the electron transfer mediator in essential biogeochemical processes such as iron bioreduction and contaminant degradation has received considerable interests in the past decade. Hypothesized electron shuttling mechanism must be evaluated based on the availability and stability of quinones under a given environmental setting. The goal of this review is to examine the source, reactivity, and fate of potential quinone catalysts with respect to chemical interactions (e.g., with other quinones and nucleophiles) that will inevitably occur in complex environmental media. We will first discuss natural and anthropogenic sources of quinones in aqueous environments, and fundamental transformation pathways including cross reaction, autoxidation, and addition reactions. We will then assess how the described sources (molecular structure) and transformation pathways (stability) will impact the ability of a quinone molecule to catalyze a biogeochemical process. Thermodynamics and kinetics of electron transfer reactions with both the electron donor (e.g., hydrogen sulfide as a bulk reductant) and the terminal electron acceptor (e.g., nitroaromatic explosives in contaminant degradation), and stability towards irreversible side reactions are the key factors determining the geochemical conditions under which the catalysis by a quinone molecule will be operative. Published by Elsevier Ltd. C1 [Uchimiya, Minori; Stone, Alan T.] Johns Hopkins Univ, Dept Geog & Environm Engn, Baltimore, MD 21218 USA. RP Uchimiya, M (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. EM Minori.Uchimiya@usace.army.mil RI Stone, Alan/A-2569-2010 OI Stone, Alan/0000-0002-3660-1129 FU USDA Cooperative State Research, Education, and Extension Service [2002-35107-11572] FX This project was supported by National Research Initiative Competitive Grant No. 2002-35107-11572 from the USDA Cooperative State Research, Education, and Extension Service. NR 85 TC 51 Z9 57 U1 18 U2 138 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD OCT PY 2009 VL 77 IS 4 BP 451 EP 458 DI 10.1016/j.chemosphere.2009.07.025 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA 514CI UT WOS:000271370900001 PM 19665164 ER PT J AU Dontsova, KM Pennington, JC Hayes, C Simunek, J Williford, CW AF Dontsova, Katerina M. Pennington, Judith C. Hayes, Charolett Simunek, Jiri Williford, Clint W. TI Dissolution and transport of 2,4-DNT and 2,6-DNT from M1 propellant in soil SO CHEMOSPHERE LA English DT Article DE 2,4-Dinitrotoluene; 2,6-Dinitrotoluene; Column studies; HYDRUS-1 D; Propellant ID COMPOSITION-B; ADSORPTION; 2,6-DINITROTOLUENE; EXPLOSIVES; RANGES AB Live-fire training exercises can result in particulate propellant contamination on military training ranges and can potentially contaminate ground water. This study was conducted to evaluate dissolution of the 2,4-dinitrotoluene (2,4-DNT) and 2,6-dinitrotoluene (2,6-DNT) from the propellant formulation, MI (87.6% nitrocellulose, 7.3% 2,4-DNT, 0.57% 2,6-DNT, 1.06% diphenylamine, 3.48% dibutyl phthalate) and their subsequent transport in soil. Batch dissolution studies were followed by saturated column transport experiments. Neat, dissolved 2,4-DNT, and M1 in solid and dissolved forms were used as influent to columns filled with Plymouth loamy sand (mesic, coated Typic Quartzipsamments) from Camp Edwards, MA. Dissolution rates and other fate and transport parameters were determined using the HYDRUS-1D code. M1 dissolution was limited by DNT diffusion from the interior of the pellet, resulting in an exponential decrease in dissolution rate with time. The HYDRUS-1D model accurately described release and transport of 2,4- and 2,6-DNT from MI propellant. Dissolution rates for M1 in the stirred reactor and column studies were similar, indicating that batch dissolution rates are potentially useful to represent field conditions. Published by Elsevier Ltd. C1 [Dontsova, Katerina M.; Williford, Clint W.] Univ Mississippi, Dept Chem Engn, University, MS 38677 USA. [Dontsova, Katerina M.; Pennington, Judith C.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Hayes, Charolett] Comp Sci Corp, Vicksburg, MS 39180 USA. [Simunek, Jiri] Univ Calif Riverside, Riverside, CA 92521 USA. RP Dontsova, KM (reprint author), Univ Arizona, Biosphere 2,Marshall Bldg,Room 526,845 N Pk Ave, Tucson, AZ 85721 USA. EM Kateryna.Dontsova@gmail.com RI Simunek, Jiri/F-3196-2011 FU Terrestrial Sciences Program of the Army Research Office (Terrestrial Processes and Landscape Dynamics and Terrestrial System Modeling and Model Integration) FX The tests described and the resulting data presented herein, unless otherwise noted, were obtained from research conducted under the US Army Environmental Quality Technology Basic Research Program by the US Army Engineer Research and Development Center. Permission was granted by the Chief of Engineers to publish this information. Work of gimunek was supported by the Terrestrial Sciences Program of the Army Research Office (Terrestrial Processes and Landscape Dynamics and Terrestrial System Modeling and Model Integration). The views expressed in this article are those of the authors' and do not reflect the official policy or position of the Department of the Army, Department of Defense, or the US Government. The use of trade, product, or firm names in this paper is for descriptive purposes only and does not imply endorsement by the US Government. NR 29 TC 17 Z9 17 U1 1 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD OCT PY 2009 VL 77 IS 4 BP 597 EP 603 DI 10.1016/j.chemosphere.2009.05.039 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA 514CI UT WOS:000271370900021 PM 19729186 ER PT J AU Thompson, JW Newman, L Boop, FA Sanford, RA AF Thompson, Jerome W. Newman, Lisa Boop, Frederick A. Sanford, Robert A. TI Management of postoperative swallowing dysfunction after ependymoma surgery SO CHILDS NERVOUS SYSTEM LA English DT Article; Proceedings Paper CT 34th Annual Meeting of the International-Society-for-Pediatric-Neurosurgery CY SEP 10-14, 2006 CL Taipei, TAIWAN SP Int Soc Pediat Neurosurg DE Ependymoma; Aspiration; Swallowing; Team; Endoscopy; Modified barium swallow AB This study aims to share a new postoperative care technique team approach for the management of children after they have recovered from the anesthetic and has passed through the immediate postoperative period of a day or so from their posterior fossa ependymoma surgery. A team approach was developed consisting of a neurosurgeon, an otolaryngologist, an intensivist, and a speech pathologist/swallowing specialist. Patients were extubated 24 h after their surgery. Vocal cord function was assessed by fiberoptic exam after extubation. Tracheostomy was occasionally necessary to secure the airway. Swallowing was assessed via modified barium swallow. Aspiration with feeding was occasionally detected early and managed with a gastrostomy tube. Forty-five patients have undergone posterior fossa surgery at our institution and were managed by our team. Nine have had sufficient vocal cord dysfunction to require a tracheostomy. Eleven have required a gastrostomy. None developed respiratory distress and none developed aspiration pneumonia. A team approach, delayed airway evaluation, and modified swallowing exams have benefited our patients after posterior fossa ependymoma surgery. We have prevented any cases of respiratory distress or aspiration pneumonia. C1 [Thompson, Jerome W.] Univ Tennessee, Dept Otolaryngol Head & Neck Surg, Memphis, TN 38163 USA. [Newman, Lisa] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Boop, Frederick A.; Sanford, Robert A.] Univ Tennessee, Dept Neurosurg, Memphis, TN 38163 USA. RP Thompson, JW (reprint author), Univ Tennessee, Dept Otolaryngol Head & Neck Surg, 910 Madison Ave,Suite 408, Memphis, TN 38163 USA. EM jthomp18@utmem.edu NR 11 TC 3 Z9 3 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0256-7040 J9 CHILD NERV SYST JI Childs Nerv. Syst. PD OCT PY 2009 VL 25 IS 10 BP 1249 EP 1252 DI 10.1007/s00381-009-0880-0 PG 4 WC Clinical Neurology; Pediatrics; Surgery SC Neurosciences & Neurology; Pediatrics; Surgery GA 494TE UT WOS:000269838900012 PM 19337738 ER PT J AU Kunz, JS Hemann, B Atwood, JE Jackson, J Wu, T Hamm, C AF Kunz, Jeffrey S. Hemann, Brian Atwood, J. Edwin Jackson, Jeffrey Wu, Timothy Hamm, Carolyn TI Is There a Link Between Gastroesophageal Reflux Disease and Atrial Fibrillation? SO CLINICAL CARDIOLOGY LA English DT Article ID ESOPHAGITIS; PREVENTION; ABLATION AB Background: Previous studies suggest a potential association between gastroesophageal reflux disease (GERD) and atrial fibrillation. Objective: To explore the potential association between GERD and atrial fibrillation. Materials and Methods: This was a retrospective study created from a database containing all health care encounters for patients who received ambulatory care in the National Capitol Area military health care system between January 1, 2001 and October 28, 2007. The study population included all subjects at least 18 years of age (n = 163 627). Our primary outcomes of interest were International Classification of Diseases, Ninth Revision (ICD-9) diagnoses of atrial fibrillation and GERD. Results: Among 163 627 patients, 7992 (5%) had atrial fibrillation and 47 845 (29%) had GERD. The presence of GERD increased the relative risk (RR) of a diagnosis of atrial fibrillation (RR: 1.39, 95% confidence interval [CI]: 1.33-1.45). In sensitivity analyses, this relationship persisted after adjustment for cardiovascular disease risk factors (RR: 1.19, 95% CI: 1.13-1.25) and diagnoses known to be strongly associated with atrial fibrillation (RR: 1.08, 95% CI: 1.02-1.13). Conclusions: The presence of GERD is associated with an increased risk of a diagnosis of atrial fibrillation. C1 [Kunz, Jeffrey S.; Hemann, Brian; Atwood, J. Edwin] Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. [Jackson, Jeffrey] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. [Wu, Timothy; Hamm, Carolyn] Walter Reed Army Med Ctr, Dept Hlth Plan Management, Washington, DC 20307 USA. RP Kunz, JS (reprint author), 6900 Georgia Ave NW, Washington, DC 20307 USA. EM jeffrey.kunz@amedd.army.mil NR 19 TC 14 Z9 14 U1 0 U2 2 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0160-9289 J9 CLIN CARDIOL JI Clin. Cardiol. PD OCT PY 2009 VL 32 IS 10 BP 584 EP 587 DI 10.1002/clc.20660 PG 4 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 521JG UT WOS:000271916400008 PM 19911354 ER PT J AU Potter, BK Adams, SC Kransdorf, MJ Temple, HT AF Potter, Benjamin K. Adams, Sheila C. Kransdorf, Mark J. Temple, H. Thomas TI A 38-year-old Man with Left Knee Pain SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Editorial Material ID NON-HODGKINS-LYMPHOMA; MALIGNANT-LYMPHOMA; CELL TUMORS; BONE; EXPERIENCE; ADULTS C1 [Potter, Benjamin K.] Walter Reed Army Med Ctr, Integrated Dept Orthopaed & Rehabil, Washington, DC 20307 USA. [Potter, Benjamin K.; Adams, Sheila C.; Kransdorf, Mark J.] Univ Miami, Miller Sch Med, Dept Orthopaed, Miami, FL 33136 USA. [Potter, Benjamin K.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. [Kransdorf, Mark J.] Mayo Clin, Dept Radiol, Jacksonville, FL 32224 USA. RP Potter, BK (reprint author), Walter Reed Army Med Ctr, Integrated Dept Orthopaed & Rehabil, 6900 Georgia Ave,NW,Bldg 2A,Room 205, Washington, DC 20307 USA. EM Benjamin.Potter@amedd.army.mil OI Potter, MD, Benjamin K./0000-0002-8771-0317 NR 20 TC 2 Z9 2 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0009-921X J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD OCT PY 2009 VL 467 IS 10 BP 2755 EP 2759 DI 10.1007/s11999-009-0716-y PG 5 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 495WR UT WOS:000269926400040 PM 19184259 ER PT J AU Pruitt, BA Wolf, SE AF Pruitt, Basil A., Jr. Wolf, Steven E. TI An Historical Perspective on Advances in Burn Care Over the Past 100 Years SO CLINICS IN PLASTIC SURGERY LA English DT Review DE Fluid rescuscitation; Stress ulcers; Inhalation injury; Burn wound care; Skin substitutes; Electric injury; Hypermetabolism; Nutrition ID ACUTE GASTRODUODENAL DISEASE; FREQUENCY PERCUSSIVE VENTILATION; LACTATED SALINE SOLUTION; SMOKE-INHALATION INJURY; THERMAL-INJURY; WOUND MANIPULATION; SHOCK; RESUSCITATION; MORTALITY; EXCISION AB The accelerated pace of clinical and laboratory research over the past century and application of the research findings to patient care have resulted in unprecedented survival of burned patients in all age groups. Resuscitation based on an understanding of the nature and magnitude of the multisystem response to injury now prevents burn shock; effective topical antimicrobial chemotherapy and early excision prevent wound toxemia and sepsis; biologic and bioengineered dressings compensate for the missing skin; and broad spectrum metabolic support regimens prevent exhaustion and accelerate convalescence. Rehabilitation programs have also been developed to restore physical function and permit the burn patient to reenter society as a productive individual. C1 [Pruitt, Basil A., Jr.; Wolf, Steven E.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA. [Pruitt, Basil A., Jr.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Pruitt, BA (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, 7703 Floyd Curl Dr,MSC 7840, San Antonio, TX 78229 USA. EM pruitt@uthscsa.edu OI Wolf, Steven/0000-0003-2972-3440 NR 110 TC 12 Z9 12 U1 0 U2 3 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0094-1298 J9 CLIN PLAST SURG JI Clin. Plast. Surg. PD OCT PY 2009 VL 36 IS 4 BP 527 EP + DI 10.1016/j.cps.2009.05.007 PG 20 WC Surgery SC Surgery GA 515CS UT WOS:000271444800002 PM 19793549 ER PT J AU Cancio, LC AF Cancio, Leopoldo C. TI Airway Management and Smoke Inhalation Injury in the Burn Patient SO CLINICS IN PLASTIC SURGERY LA English DT Article DE Smoke inhalation injury; Burns; Burns inhalation; Carbon monoxide poisoning; Hydrogen cyanide; High-frequency ventilation ID FREQUENCY PERCUSSIVE VENTILATION; ACUTE LUNG INJURY; CARBON-MONOXIDE; EARLY-DIAGNOSIS; CONVENTIONAL VENTILATION; FIBEROPTIC BRONCHOSCOPY; RESPIRATORY-FAILURE; FLUID RESUSCITATION; EARLY TRACHEOSTOMY; PULMONARY-FUNCTION AB Smoke inhalation injury, a unique form of acute lung injury, greatly increases the occurrence of postburn morbidity and mortality. In addition to early intubation for upper-airway protection, subsequent critical care of patients who have this injury should be directed at maintaining distal airway patency. High-frequency ventilation, inhaled heparin, and aggressive pulmonary toilet are among the therapies available. Even so, immunosuppression, intubation, and airway damage predispose these patients to pneumonia and other complications. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Cancio, LC (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM Lee.cancio@us.army.mil NR 87 TC 38 Z9 39 U1 0 U2 5 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0094-1298 J9 CLIN PLAST SURG JI Clin. Plast. Surg. PD OCT PY 2009 VL 36 IS 4 BP 555 EP + DI 10.1016/j.cps.2009.05.013 PG 14 WC Surgery SC Surgery GA 515CS UT WOS:000271444800004 PM 19793551 ER PT J AU Larkin, EA Carman, RJ Krakauer, T Stiles, BG AF Larkin, E. A. Carman, R. J. Krakauer, T. Stiles, B. G. TI Staphylococcus aureus: The Toxic Presence of a Pathogen Extraordinaire SO CURRENT MEDICINAL CHEMISTRY LA English DT Review DE Animal model; cytokine; immunotherapeutic; receptor; Stapylococcus aureus; superantigen; toxic shock; vaccine ID SHOCK-SYNDROME TOXIN-1; T-CELL-RECEPTOR; MAJOR HISTOCOMPATIBILITY COMPLEX; BLOOD MONONUCLEAR-CELLS; CLOSTRIDIUM-PERFRINGENS ENTEROTOXIN; TUMOR-NECROSIS-FACTOR; CLASS-II-BINDING; STREPTOCOCCAL PYROGENIC TOXINS; BACTERIAL SUPERANTIGEN; IN-VIVO AB Staphylococcus aureus is a facultative, Gram-positive coccus well known for its disease-causing capabilities. In particular, methicillin and vancomycin resistant strains of S. aureus (MRSA and VRSA, respectively) isolated globally represent daunting medical challenges for the 21(st) Century. This bacterium causes numerous illnesses in humans such as food poisoning, skin infections, osteomyelitis, endocarditis, pneumonia, enterocolitis, toxic shock, and autoimmune disorders. A few of the many virulence factors attributed to S. aureus include antibiotic resistance, capsule, coagulase, lipase, hyaluronidase, protein A, fibronectin-binding protein, and multiple toxins with diverse activities. One family of protein toxins is the staphylococcal enterotoxins (SEs) and related toxic shock syndrome toxin-1 (TSST-1) that act as superantigens. There are more than twenty different SEs described to date with varying amino acid sequences, common conformations, and similar biological effects. By definition, very low (picomolar) concentrations of these superantigenic toxins activate specific T-cell subsets after binding to major histocompatibility complex class II. Activated T-cells vigorously proliferate and release proinflammatory cytokines plus chemokines that can elicit fever, hypotension, and other ailments which include a potentially lethal shock. In vitro and in vivo models are available for studying the SEs and TSST-1, thus providing important tools for understanding modes of action and subsequently countering these toxins via experimental vaccines or therapeutics. This review succinctly presents the pathogenic ways of S. aureus, with a toxic twist. There will be a particular focus upon the biological and biochemical properties of, plus current neutralization strategies targeting, staphylcoccocal superantigens like the SEs and TSST-1. C1 [Stiles, B. G.] USA, Med Res Inst Infect Dis, Dept Immunol, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. [Larkin, E. A.] Hood Coll, Frederick, MD 21701 USA. [Carman, R. J.] TechLab Inc, Blacksburg, VA USA. [Stiles, B. G.] Wilson Coll, Chambersburg, PA USA. RP Stiles, BG (reprint author), USA, Med Res Inst Infect Dis, Dept Immunol, Integrated Toxicol Div, Bldg 1425, Ft Detrick, MD 21702 USA. EM bstiles@wilson.edu FU Defense Threat Reduction Agency (DTRA); Wilson College FX Funding for this, and other related projects, has been generously provided by the Defense Threat Reduction Agency (DTRA) and Wilson College. This research was supported in part by an appointment (EAL) to the Postgraduate Research Participation Program at the U. S. Army Medical Research Institute of Infectious Diseases. Administration was provided by the Oak Ridge Institute for Science and Eduation through an interagency agreement between the U. S. Department of Energy and the U. S. Army Medical Research and Materiel Command. NR 214 TC 61 Z9 68 U1 1 U2 32 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 0929-8673 J9 CURR MED CHEM JI Curr. Med. Chem. PD OCT PY 2009 VL 16 IS 30 BP 4003 EP 4019 PG 17 WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy GA 514GL UT WOS:000271382300007 PM 19747126 ER PT J AU Aungst, MJ Sears, CLG Fischer, JR AF Aungst, Matthew J. Sears, Christine L. G. Fischer, John R. TI Ureteral stents and retrograde studies: a primer for the gynecologist SO CURRENT OPINION IN OBSTETRICS & GYNECOLOGY LA English DT Article DE contrast media; fistula; stent; ureter; urography ID URINARY-TRACT-INFECTION; RANDOMIZED CONTROLLED TRIAL; URETEROSCOPIC LITHOTRIPSY; ENDOUROLOGICAL MANAGEMENT; ARTERIOURETERAL FISTULA; URETEROVAGINAL FISTULAS; PSOAS HITCH; COMPLICATIONS; SYMPTOMS; SURGERY AB Purpose of review To review basic techniques and recent advances in endourology for the practicing gynecologist. Recent findings New ureteral stent designs are available to improve comfort and reduce some of the complications of indwelling ureteral stents. A large prospective study failed to show a significant benefit of prophylactic ureteral catheterization prior to major gynecological surgery to reduce the risk of ureteral injury. There is a shift in the management of some iatrogenic ureteric injuries from surgical reimplantation to more conservative endoscopic management by interventional radiologists and urologists. Summary The indications, techniques, and complications of advanced endourology techniques including the use of indwelling ureteral stents and retrograde pyelography are reviewed. Indwelling ureteral stents are used to establish and maintain patency of the ureters for many indications, including specific gynecological indications such as iatrogenic ureteral injury, ureteric fistula, extrinsic compression from tumor, and prophylactically to prevent ureteric injury. Retrograde pyelography is a very useful technique to image the renal collecting system with particular utility in patients with contraindications to intravenous contrast and to investigate suspected iatrogenic ureteral injuries. C1 [Aungst, Matthew J.; Fischer, John R.] Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Female Pelv Med & Reconstruct Surg, Washington, DC 20307 USA. [Sears, Christine L. G.] Natl Naval Med Ctr, Dept Urol, Bethesda, MD USA. RP Aungst, MJ (reprint author), Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Female Pelv Med & Reconstruct Surg, Bldg 2,Room 2J06,6900 Georgia Ave, Washington, DC 20307 USA. EM Matt.Aungst@yahoo.com NR 69 TC 1 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1040-872X J9 CURR OPIN OBSTET GYN JI Curr. Opin. Obstet. Gynecol. PD OCT PY 2009 VL 21 IS 5 BP 434 EP 441 DI 10.1097/GCO.0b013e32832fd23a PG 8 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 497LX UT WOS:000270062100013 PM 19606030 ER PT J AU Desocio, PA Hoffman, HG Morrow, M Maiers, A Gaylord, K Maani, C AF Desocio, Peter A. Hoffman, Hunter G. Morrow, Michelle Maiers, Alan Gaylord, Kathryn Maani, Christopher TI Combining Ketamine and Virtual Reality Pain Control During Severe Burn Wound Care: One Military Patient SO CYBERPSYCHOLOGY & BEHAVIOR LA English DT Meeting Abstract C1 [Desocio, Peter A.; Morrow, Michelle; Maiers, Alan; Gaylord, Kathryn; Maani, Christopher] USA, Inst Surg Res, Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Hoffman, Hunter G.] Univ Washington, Human Interface Technol Lab, Seattle, WA 98195 USA. [Hoffman, Hunter G.] Univ Washington, Dept Mech Engn, Seattle, WA 98195 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1094-9313 J9 CYBERPSYCHOL BEHAV JI CyberPsychol. Behav. PD OCT PY 2009 VL 12 IS 5 BP 604 EP 605 PG 2 WC Communication; Psychology, Applied SC Communication; Psychology GA 504ZC UT WOS:000270656000047 ER PT J AU Folen, RA Miyahira, SD Stetz, M AF Folen, Raymond A. Miyahira, Sarah D. Stetz, Melba TI Immersive Panoramic Video Display Compared to Flat Screen Display: Psychological and Physiological Reactions to Anger Stimuli SO CYBERPSYCHOLOGY & BEHAVIOR LA English DT Meeting Abstract ID THERAPY C1 [Folen, Raymond A.; Stetz, Melba] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Miyahira, Sarah D.] VA Pacific Isl Hlth Care Syst, Honolulu, HI USA. [Miyahira, Sarah D.] Pacific Telehlth & Technol Hui, Honolulu, HI USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1094-9313 J9 CYBERPSYCHOL BEHAV JI CyberPsychol. Behav. PD OCT PY 2009 VL 12 IS 5 BP 607 EP 608 PG 2 WC Communication; Psychology, Applied SC Communication; Psychology GA 504ZC UT WOS:000270656000050 ER PT J AU Gaylord, K Hoffman, HG Maiers, A Maani, C Miyahira, S Garcia-Palacios, A Rothbaum, B Difede, J AF Gaylord, Kathryn Hoffman, Hunter G. Maiers, Alan Maani, Christopher Miyahira, Sarah Garcia-Palacios, Azucena Rothbaum, Barbara Difede, JoAnn TI VRE Therapy plus D-Cycloserine (DCS) for Treating PTSD in Patients with Combat-Related Burn Injuries SO CYBERPSYCHOLOGY & BEHAVIOR LA English DT Meeting Abstract C1 [Gaylord, Kathryn; Maiers, Alan; Maani, Christopher] USA, Inst Surg Res, BAMC, Ft Sam Houston, TX 78234 USA. [Hoffman, Hunter G.] Univ Washington, Seattle, WA 98195 USA. [Miyahira, Sarah] Pacific Telehlth & Technol Hui, Honolulu, HI USA. [Garcia-Palacios, Azucena] Univ Jaume 1, Castellon de La Plana, Spain. [Rothbaum, Barbara] Emory Univ, Atlanta, GA 30322 USA. [Difede, JoAnn] Cornell Presbyterian Hosp, Manhattan, KS USA. RI Garcia-Palacios, Azucena/C-9854-2011 OI Garcia-Palacios, Azucena/0000-0001-9250-8714 NR 1 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1094-9313 J9 CYBERPSYCHOL BEHAV JI CyberPsychol. Behav. PD OCT PY 2009 VL 12 IS 5 BP 608 EP 609 PG 2 WC Communication; Psychology, Applied SC Communication; Psychology GA 504ZC UT WOS:000270656000052 ER PT J AU Miyahira, SD Folen, RA Hoffman, HG Garcia-Palacios, A AF Miyahira, Sarah D. Folen, Raymond A. Hoffman, Hunter G. Garcia-Palacios, Azucena TI Treating Combat PTSD with Virtual Reality Exposure Therapy SO CYBERPSYCHOLOGY & BEHAVIOR LA English DT Meeting Abstract ID POSTTRAUMATIC-STRESS-DISORDER C1 [Miyahira, Sarah D.] Pacific Isl Hlth Care Syst, Vet Affairs, Honolulu, HI USA. [Miyahira, Sarah D.] Pacific Telehlth & Technol Hui, Honolulu, HI USA. [Folen, Raymond A.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Hoffman, Hunter G.] Univ Washington, Seattle, WA 98195 USA. [Garcia-Palacios, Azucena] Univ Jaume 1, Castellon de La Plana, Spain. RI Garcia-Palacios, Azucena/C-9854-2011 OI Garcia-Palacios, Azucena/0000-0001-9250-8714 NR 4 TC 0 Z9 0 U1 0 U2 6 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1094-9313 J9 CYBERPSYCHOL BEHAV JI CyberPsychol. Behav. PD OCT PY 2009 VL 12 IS 5 BP 640 EP 641 PG 2 WC Communication; Psychology, Applied SC Communication; Psychology GA 504ZC UT WOS:000270656000090 ER PT J AU Stetz, MC Bouchard, S Wiederhold, BK Riva, G Folen, RA AF Stetz, Melba C. Bouchard, Stephane Wiederhold, Brenda K. Riva, Giuseppe Folen, Raymond A. TI The Receptiveness of Stress Management Techniques by Military Personnel SO CYBERPSYCHOLOGY & BEHAVIOR LA English DT Meeting Abstract C1 [Stetz, Melba C.; Folen, Raymond A.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Bouchard, Stephane] Univ Quebec Outaouais, Quebec City, PQ, Canada. [Wiederhold, Brenda K.] Virtual Real Med Ctr, San Diego, CA USA. [Riva, Giuseppe] Inst Auxol Italiano, Milan, Italy. NR 1 TC 0 Z9 0 U1 1 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1094-9313 J9 CYBERPSYCHOL BEHAV JI CyberPsychol. Behav. PD OCT PY 2009 VL 12 IS 5 BP 660 EP 661 PG 2 WC Communication; Psychology, Applied SC Communication; Psychology GA 504ZC UT WOS:000270656000113 ER PT J AU Weeks, SR Pasquina, PF Tsao, JW AF Weeks, Sharon R. Pasquina, Paul F. Tsao, Jack W. TI A Control Method for Advanced Upper Extremity Prostheses Using Pattern Recognition and Virtual Reality SO CYBERPSYCHOLOGY & BEHAVIOR LA English DT Meeting Abstract C1 [Weeks, Sharon R.; Pasquina, Paul F.; Tsao, Jack W.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1094-9313 J9 CYBERPSYCHOL BEHAV JI CyberPsychol. Behav. PD OCT PY 2009 VL 12 IS 5 BP 666 EP 667 PG 2 WC Communication; Psychology, Applied SC Communication; Psychology GA 504ZC UT WOS:000270656000119 ER PT J AU Wiederhold, MD Salva, AM Sotomayor, T Coiro, C Wiederhold, BK AF Wiederhold, Mark D. Salva, Angela M. Sotomayor, Teresita Coiro, Cheryl Wiederhold, Brenda K. TI Next-Generation Stress Inoculation Training for Life-Saving Skills Using Prosthetics SO CYBERPSYCHOLOGY & BEHAVIOR LA English DT Meeting Abstract C1 [Wiederhold, Mark D.; Wiederhold, Brenda K.] Virtual Real Med Ctr, Orlando, FL USA. [Salva, Angela M.; Coiro, Cheryl] Virtual Real Med Ctr, San Diego, CA USA. [Sotomayor, Teresita] USA, Res Dev & Engn, Command Simulat & Training Technol Ctr, Orlando, FL USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1094-9313 J9 CYBERPSYCHOL BEHAV JI CyberPsychol. Behav. PD OCT PY 2009 VL 12 IS 5 BP 668 EP 669 PG 2 WC Communication; Psychology, Applied SC Communication; Psychology GA 504ZC UT WOS:000270656000122 ER PT J AU Hartley, T Wanner, T AF Hartley, Tina Wanner, Thomas TI A SEMI-IMPLICIT SPECTRAL METHOD FOR STOCHASTIC NONLOCAL PHASE-FIELD MODELS SO DISCRETE AND CONTINUOUS DYNAMICAL SYSTEMS LA English DT Article DE Phase-field model; nonlocal interaction; additive stochastic noise; spectral method; phase separation ID CAHN-HILLIARD EQUATION; LONG-TIME BEHAVIOR; SPINODAL DECOMPOSITION; DIFFERENTIAL-EQUATIONS; PATTERN-FORMATION; HIGHER DIMENSIONS; DYNAMICS; SOLIDIFICATION; TRANSITIONS; SYSTEM AB The classical phase-field model has been introduced as a model for non-isothermal phase separation processes in materials. In order to overcome some of the model's shortcomings, a variety of extensions have recently been proposed which include nonlocal interactions as well as stochastic noise terms. In this paper, we study these extensions from a functional-analytic and numerical point of view. More precisely, we present a functional-analytic framework for establishing existence, uniqueness, and qualitative dynamical results, and then propose a spectral method for solving stochastic nonlocal phase-field models. In particular, we establish convergence properties of our method and study the effects of noise regularity and of the nonlocal interaction term on these convergence properties. Finally, numerical studies relating to the associated phase separation process are presented. C1 [Hartley, Tina] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Wanner, Thomas] George Mason Univ, Dept Math Sci, Fairfax, VA 22030 USA. RP Hartley, T (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM tina.hartley@usma.edu; wanner@math.gmu.edu RI Madruga, Santiago/D-2984-2012 FU NSF [DMS-0406231]; United States Army under the Army Advanced Civil Schooling Program; U. S. Department of Energy [DE-FG0205ER25712] FX Tina Hartley was partially supported by NSF grant DMS-0406231 and the United States Army under the Army Advanced Civil Schooling Program. Thomas Wanner was partially supported by NSF grant DMS-0406231 and the U. S. Department of Energy under Contract DE-FG0205ER25712. NR 60 TC 7 Z9 7 U1 0 U2 4 PU AMER INST MATHEMATICAL SCIENCES PI SPRINGFIELD PA PO BOX 2604, SPRINGFIELD, MO 65801-2604 USA SN 1078-0947 EI 1553-5231 J9 DISCRETE CONT DYN-A JI Discret. Contin. Dyn. Syst. PD OCT PY 2009 VL 25 IS 2 BP 399 EP 429 DI 10.3934/dcds.2009.25.399 PG 31 WC Mathematics, Applied; Mathematics SC Mathematics GA 468EJ UT WOS:000267797500001 ER PT J AU Gonzalez, CF Cropek, DM Henry, CS AF Gonzalez, Carlos F. Cropek, Donald M. Henry, Charles S. TI Photopatternable Carbon Electrodes for Chip-Based Electrochemical Detection SO ELECTROANALYSIS LA English DT Article DE Photopatternable carbon; Microfluidics; Voltammetry ID MICROCHIP CAPILLARY-ELECTROPHORESIS; ENZYME-IMMUNOASSAY; AMINOPHENYL PHOSPHATE; 4-AMINOPHENOL; FABRICATION; DEVICES AB Presented is the preparation and initial characterization of carbonaceous electrodes prepared using photolithographic techniques. The electrodes were created using a graphite doped photoresist mixture which allowed for direct electrode patterning. The electrodes were tested using cyclic voltammetry with a Fe(CN)(6)(3-/4-) test solution and were found to exhibit a linear response as per the Randles-Sevick relation. The feasibility of using these electrodes to conduct biological assays was demonstrated with p-aminophenol, a common analyte in electrochemical ELISAs, using differential pulse voltammetry. C1 [Gonzalez, Carlos F.; Henry, Charles S.] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA. [Gonzalez, Carlos F.; Cropek, Donald M.] USA, Construct Engn Res Lab, Engineer Res & Dev Ctr, Champaign, IL 61822 USA. RP Henry, CS (reprint author), Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA. EM chuck.heary@colostate.edu OI Henry, Charles/0000-0002-8671-7728 FU U.S. Department of Energy and ERDC-CERL FX This research was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Engineer Research and Development Center-Construction Engineering Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and ERDC-CERL. NR 22 TC 7 Z9 7 U1 2 U2 13 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 1040-0397 J9 ELECTROANAL JI Electroanalysis PD OCT PY 2009 VL 21 IS 19 BP 2171 EP 2174 DI 10.1002/elan.200904643 PG 4 WC Chemistry, Analytical; Electrochemistry SC Chemistry; Electrochemistry GA 506JL UT WOS:000270771000013 ER PT J AU Dorji, T Yoon, IK Holmes, EC Wangchuk, S Tobgay, T Nisalak, A Chinnawirotpisan, P Sangkachantaranon, K Gibbons, RV Jarman, RG AF Dorji, Tandin Yoon, In-Kyu Holmes, Edward C. Wangchuk, Sonam Tobgay, Tashi Nisalak, Ananda Chinnawirotpisan, Piyawan Sangkachantaranon, Kanittha Gibbons, Robert V. Jarman, Richard G. TI Diversity and Origin of Dengue Virus Serotypes 1, 2, and 3, Bhutan SO EMERGING INFECTIOUS DISEASES LA English DT Article ID NEPAL AB To determine the serotype and genotype of dengue virus (DENV) in Bhutan, we conducted phylogenetic analyses of complete envelope gene sequences. DENV-2 (Cosmopolitan genotype) predominated in 2004, and DENV-3 (genotype III) predominated in 2005-2006; these viruses were imported from India. Primary dengue infections outnumbered secondary infections, suggesting recent emergence. C1 [Dorji, Tandin] Minist Hlth, Thimphu, Bhutan. [Yoon, In-Kyu; Nisalak, Ananda; Chinnawirotpisan, Piyawan; Sangkachantaranon, Kanittha; Gibbons, Robert V.; Jarman, Richard G.] US Army Med Command, Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Holmes, Edward C.] Penn State Univ, University Pk, PA 16802 USA. [Holmes, Edward C.] NIH, Bethesda, MD 20892 USA. [Tobgay, Tashi] Minist Hlth, Gelephu, Bhutan. EM richard.jarman@afrims.org RI Valle, Ruben/A-7512-2013; OI Holmes, Edward/0000-0001-9596-3552 NR 9 TC 23 Z9 23 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD OCT PY 2009 VL 15 IS 10 BP 1630 EP 1632 DI 10.3201/eid1510.090123 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 503ZD UT WOS:000270580600015 PM 19861059 ER PT J AU Wang, GX Gertner, G Anderson, A Howard, H AF Wang, Guangxing Gertner, George Anderson, Alan Howard, Heidi TI Simulating Spatial Pattern and Dynamics of Military Training Impacts for Allocation of Land Repair Using Images SO ENVIRONMENTAL MANAGEMENT LA English DT Article DE Cumulative impacts; Landsat TM imagery; Land repair and restoration; Loss function; Spatial simulation; Uncertainty ID VEGETATION COVER FACTOR; TRACKED VEHICLES; SOIL-EROSION; FORT-HOOD; CLASSIFICATION; DISTURBANCE; MANAGEMENT; FEATURES; TEXTURE; QUALITY AB The land management of US Army installations requires information on land conditions and their history for planning future military training activities and allocation of land repair. There is thus a strong need for methodology development to estimate the land conditions and cumulative military training impacts for the purpose of repair and restoration. In this study, we simulated at Fort Riley, USA, spatial patterns and temporal dynamics of military training impacts on land conditions quantified as percent ground cover using an image-aided spatial conditional co-simulation algorithm. Moreover, we estimated the historical percent ground cover as a measure of the cumulative impacts, and then calculated the allocation of land repair and restoration based on both current and historical land conditions. In addition, we developed a loss function method for allocation of land repair and restoration. The results showed: (1) this co-simulation algorithm reproduced spatial and temporal variability of percent ground cover and provided estimates of uncertainties with the correlation coefficients and root mean square errors between the simulated and observed values varying from 0.63 to 0.88 and from 23% to 78%, respectively; (2) with and without the cumulative impacts, the obtained spatial patterns of the land repair categories were similar, but their land areas differed by 5% to 40% in some years; (3) the combination of the loss function with the co-simulation made it possible to estimate and computationally propagate the uncertainties of land conditions into the uncertainties of expected cost loss for misallocation of land repair and restoration; and (4) the loss function, physical threshold, and probability threshold methods led to similar spatial patterns and temporal dynamics of the land repair categories, however, the loss function increased the land area by 5% to 30% for intense and moderate repairs and decreased the area by 5% to 30% for no repairs and light repairs for most of the years. This approach provided the potential to improve and automate the existing land rehabilitation and maintenance (LRAM) system used for the land management of the U. S. Army installations, and it can be applied to the management of other civil lands and environments. In conclusion, this study overcame the important gaps that exist in the methodological development and application for simulating land conditions and cumulative impacts due to human activities, and also in the methods for the allocation of land for repair and restoration. C1 [Gertner, George] Univ Illinois, Urbana, IL 61801 USA. [Wang, Guangxing] So Illinois Univ, Carbondale, IL 62901 USA. [Anderson, Alan; Howard, Heidi] USA Corps Engineers, CERL, Champaign, IL 61822 USA. RP Gertner, G (reprint author), Univ Illinois, W503 Turner Hall,1102 S Goodwin Ave, Urbana, IL 61801 USA. EM gertner@illinois.edu FU US Army Corps of Engineers, Construction Engineering Research Laboratory (USA-CERL) [CERL W9132T-06-2-0001] FX We are grateful to US Army Corps of Engineers, Construction Engineering Research Laboratory (USA-CERL) for providing support (CERL W9132T-06-2-0001) and data sets for this study; and to the editors and reviewers for their helpful comments. NR 39 TC 6 Z9 6 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0364-152X J9 ENVIRON MANAGE JI Environ. Manage. PD OCT PY 2009 VL 44 IS 4 BP 810 EP 823 DI 10.1007/s00267-009-9363-z PG 14 WC Environmental Sciences SC Environmental Sciences & Ecology GA 502HR UT WOS:000270448900017 PM 19707707 ER PT J AU Sarrazin, M Dodard, SG Savard, K Lachance, B Robidoux, PY Kuperman, RG Hawari, J Ampleman, G Thiboutot, S Sunahara, GI AF Sarrazin, Manon Dodard, Sabine G. Savard, Kathleen Lachance, Bernard Robidoux, Pierre Y. Kuperman, Roman G. Hawari, Jalal Ampleman, Guy Thiboutot, Sonia Sunahara, Geoffrey I. TI ACCUMULATION OF HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE BY THE EARTHWORM EISENIA ANDREI IN A SANDY LOAM SOIL SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Earthworm; Hexahydro-1,3,5-trinitro-1,3,5-triazine; Explosives; Bioaccumulation; Soil ID HETEROCYCLIC EXPLOSIVES RDX; BIOACCUMULATION; TOXICITY; HMX; REPRODUCTION; OLIGOCHAETA; SURVIVAL; WORMS; FATE; 2,4,6-TRINITROTOLUENE AB The heterocyclic polynitramine hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) is a highly energetic compound found as a soil contaminant at some defense installations. Although RDX is not lethal to soil invertebrates at concentrations up to 10,000 mg/kg, it decreases earthworm cocoon formation and juvenile production at environmentally relevant concentrations found at contaminated sites. Very little is known about the uptake of RDX in earthworms and the potential risks for food-chain transfer of RDX in the environment. Toxicokinetic studies were conducted to quantify the bioaccumulation factors (BAFs) using adult earthworms (Eisenia andrei) exposed for up to 14 d to sublethal concentrations of nonlabeled RDX or [(14)C] RDX in a Sassafras sandy loam soil. High-performance liquid chromatography of acetonitrile extracts of tissue and soil samples indicated that nonlabeled RDX can be accumulated by the earthworm in a concentration- and time-dependent manner. The BAF, expressed as the earthworm tissue to soil concentration ratio, decreased from 6.7 to 0.1 when the nominal soil RDX concentrations were increased from 1 to 10,000 mg/kg. Tissue concentrations were comparable in earthworms exposed to nonlabeled RDX or [(14)C]RDX. The RDX bioaccumulation also was estimated using the kinetically derived model (BAF(K)), based on the ratio of the uptake to elimination rate constants. The established BAF(K) of 3.6 for [(14)C]RDX uptake was consistent with the results for nonlabeled RDX. Radioactivity also was present in the tissue residues of [(14)C]RDX-exposed earthworms following acetonitrile extraction, suggesting the formation of nonextractable [(14)C]RDX metabolites associated with tissue macromolecules. These findings demonstrated a net accumulation of RDX in the earthworm and the potential for food-chain transfer of RDX to higher-trophic-level receptors. C1 [Sarrazin, Manon; Dodard, Sabine G.; Savard, Kathleen; Lachance, Bernard; Robidoux, Pierre Y.; Hawari, Jalal; Sunahara, Geoffrey I.] Natl Res Council Canada, Biotechnol Res Inst, Montreal, PQ H4P 2R2, Canada. [Kuperman, Roman G.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Ampleman, Guy; Thiboutot, Sonia] Def Res & Dev Canada Valcartier, Val Belair, PQ G3J 1X5, Canada. RP Sunahara, GI (reprint author), Natl Res Council Canada, Biotechnol Res Inst, 6100 Royalmount Ave, Montreal, PQ H4P 2R2, Canada. EM geoffrey.sunahara@cnrc-nrc.gc.ca RI Kuperman, Roman/D-4297-2009 FU U. S. Department of Defense [ER-1256, ER-1416] FX This research project was supported by the U. S. Department of Defense through the Strategic Environmental Research and Development Program (SERDP Projects ER-1256 and ER-1416). The authors give special thanks to Alain Corriveau and Louise Paquet for their technical support. The authors also thank Boris Tartakovsky for his review of an earlier version of this manuscript. NR 40 TC 13 Z9 13 U1 4 U2 17 PU SETAC PRESS PI PENSACOLA PA 1010 N 12TH AVE, PENSACOLA, FL 32501-3367 USA SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD OCT PY 2009 VL 28 IS 10 BP 2125 EP 2133 PG 9 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 492VI UT WOS:000269688800014 PM 19432505 ER PT J AU Pandey, J Mesngon, M Hebbar, S Smith, D AF Pandey, J. Mesngon, M. Hebbar, S. Smith, D. TI CAN DEFECTIVE RETROGRADE AXONAL TRANSPORT CAUSE SEIZURES? SO EPILEPSIA LA English DT Meeting Abstract CT 28th International Epilespy Congress CY 2009 CL Budapest, HUNGARY C1 [Pandey, J.; Hebbar, S.; Smith, D.] Univ S Carolina, Dept Biol Sci, Columbia, SC 29208 USA. [Mesngon, M.] USA, Aberdeen, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0013-9580 J9 EPILEPSIA JI Epilepsia PD OCT PY 2009 VL 50 BP 128 EP 129 PG 2 WC Clinical Neurology SC Neurosciences & Neurology GA 502DB UT WOS:000270433800466 ER PT J AU Holliday, C Rummel, S Hooke, JA Shriver, CD Ellsworth, DL Ellsworth, RE AF Holliday, Charvonne Rummel, Seth Hooke, Jeffrey A. Shriver, Craig D. Ellsworth, Darrell L. Ellsworth, Rachel E. TI Genomic instability in the breast microenvironment? A critical evaluation of the evidence SO EXPERT REVIEW OF MOLECULAR DIAGNOSTICS LA English DT Review DE allelic imbalance; breast cancer; breast tumor microenvironment; copy number change; formalin-fixed paraffin-embedded; loss of heterozygosity; microsatellite; stroma ID CAPILLARY ARRAY ELECTROPHORESIS; NORMAL TISSUE ADJACENT; TUMOR-MICROENVIRONMENT; COPY NUMBER; ALLELIC IMBALANCE; MOLECULAR CHARACTERIZATION; FIELD CANCERIZATION; GENETIC ALTERATIONS; CANCER DEVELOPMENT; EPITHELIAL-CELLS AB Tumor-associated stroma plays an active role in breast pathogenesis, with alterations in cell signaling, proliferation and angiogenesis contributing to successful tumorigenesis. Although epigenetic modifications to DNA, as well as changes in RNA and protein expression have been identified in tumor-associated stroma, there is considerable debate regarding the presence of chromosomal alterations, detected as loss of heterozygosity/allelic imbalance events in histologically normal stromal cells adjacent to the breast carcinomas. Previous studies have detected loss of heterozygosity/allelic imbalance at varying distances from the tumor margin, and patterns of chromosomal change have been linked to tumor grade and lymph node status. By contrast, recent reports challenge the presence of genomic instability in stromal cells of the breast tumor microenvironment, leading to the speculation that the loss of heterozygosity/allelic imbalance studies, based almost exclusively on microsatellite-based profiling of formalin-fixed, paraffin-embedded tissues, do not accurately measure the true genomic content of the tumor microenvironment but rather are a reflection of technological artifact. In this perspective, we present evidence surrounding the debate and critically evaluate arguments, both pros and cons, over the presence or absence of genomic instability tumor-associated stroma. C1 [Ellsworth, Rachel E.] Henry M Jackson Fdn Advancement Mil Med, Clin Breast Care Project, Windber, PA 15963 USA. [Holliday, Charvonne; Rummel, Seth; Ellsworth, Darrell L.] Windber Res Inst, Clin Breast Care Project, Windber, PA 15963 USA. [Hooke, Jeffrey A.; Shriver, Craig D.] Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC 20307 USA. RP Ellsworth, RE (reprint author), Henry M Jackson Fdn Advancement Mil Med, Clin Breast Care Project, 620 7th St, Windber, PA 15963 USA. EM c.holliday@wriwindber.org; s.rummel@wriwindber.org; jeffrey.hooke1@us.army.mil; craig.shriver@us.army.mil; ellsworth@wriwindber.org; r.ellsworth@wriwindber.org OI Holliday, Charvonne/0000-0003-2447-115X NR 68 TC 6 Z9 6 U1 0 U2 2 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1473-7159 J9 EXPERT REV MOL DIAGN JI Expert Rev. Mol. Diagn. PD OCT PY 2009 VL 9 IS 7 BP 667 EP 678 DI 10.1586/ERM.09.55 PG 12 WC Pathology SC Pathology GA 512PA UT WOS:000271261000005 PM 19817552 ER PT J AU Brooks, M AF Brooks, M. TI A LIFE-COURSE ANALYSIS OF HEALTH AND FUNCTIONING ACROSS FOUR US WAR ERAS SO GERONTOLOGIST LA English DT Meeting Abstract C1 [Brooks, M.] US Army Baylor, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU GERONTOLOGICAL SOC AMER PI WASHINGTON PA 1030 15TH ST NW, STE 250, WASHINGTON, DC 20005202-842 USA SN 0016-9013 J9 GERONTOLOGIST JI Gerontologist PD OCT PY 2009 VL 49 BP 516 EP 516 PG 1 WC Gerontology SC Geriatrics & Gerontology GA 519UL UT WOS:000271794200525 ER PT J AU Krivak, TC Tian, CQ Rose, GS Armstrong, DK Maxwell, GL AF Krivak, Thomas C. Tian, Chunqiao Rose, G. Scott Armstrong, Deborah K. Maxwell, G. Larry TI A Gynecologic Oncology Group Study of serum CA-125 levels in patients with stage III optimally debulked ovarian cancer treated with intraperitoneal compared to intravenous chemotherapy: An analysis of patients enrolled in GOG 172 SO GYNECOLOGIC ONCOLOGY LA English DT Article DE CA-125; Intraperitoneal chemotherapy; Ovarian cancer ID TUMOR-ASSOCIATED ANTIGEN; MONOCLONAL-ANTIBODY; CARCINOMA; SURVIVAL; CISPLATIN; PREDICT; PERITONEAL; PACLITAXEL; SURGERY AB Objective. Serum CA-125 values have been advocated in the monitoring of ovarian cancer patients receiving intravenous (IV) chemotherapy. This evaluation sought to determine if the CA-125 test can be used to monitor treatment effect among patients receiving intraperitoneal chemotherapy (IP). Methods. Patient charts from a phase III clinical trial (GOG 172) were retrospectively reviewed. Serum CA125 levels prior to each cycle of therapy were collected and compared between the IV and IP chemotherapy delivery. The association between CA-125 and progression-free Survival (PFS) or overall survival (OS) was estimated and the homogeneity of the results between IP and IV chemotherapy was assessed. Results. A total of 177 patients were treated with IV chemotherapy and 165 patients with IP chemotherapy with CA-125 data available were included in this analysis. The observed difference was not statistically significant in median CA-125 levels between the IV and IP arms at any time point (P>0.05 for all). Following surgery and adjuvant chemotherapy, patients with an abnormal CA-125 >35 U/ml were 2.45 times more likely to have disease progression (95% CI: 1.52-3.95, P<0.001) and 2.78 times more likely to die of disease (95% CI: 1.66-4.65, P<0.001), compared to those with a CA-125 <35 U/ml. These results were consistent with IP and IV chemotherapy. Conclusion. Serum CA-125 levels decrease in a similar manner during IP chemotherapy when compared to IV chemotherapy. Serum CA-125 algorithms for monitoring treatment effect that have been established for IV chemotherapy may also be applied for patients receiving IP chemotherapy. (C) 2009 Elsevier Inc. All rights reserved. C1 [Krivak, Thomas C.] Univ Pittsburgh, Magee Womens Hosp, Med Ctr, Div Gynecol Oncol, Pittsburgh, PA 15213 USA. [Tian, Chunqiao] Roswell Pk Canc Inst, Stat & Data Ctr, Gynecol Oncol Grp, Buffalo, NY 14263 USA. [Rose, G. Scott; Maxwell, G. Larry] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Armstrong, Deborah K.] Johns Hopkins Kimmel Canc Ctr, Baltimore, MD 21231 USA. RP Krivak, TC (reprint author), Univ Pittsburgh, Magee Womens Hosp, Med Ctr, Div Gynecol Oncol, 300 Halket St, Pittsburgh, PA 15213 USA. EM tkrivak@mail.magee.edu FU NCI NIH HHS [CA 27469, CA 37517, P30 CA006973, U10 CA027469, U10 CA037517] NR 26 TC 13 Z9 15 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD OCT PY 2009 VL 115 IS 1 BP 81 EP 85 DI 10.1016/j.ygyno.2009.06.021 PG 5 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 496IZ UT WOS:000269965700016 PM 19596139 ER PT J AU Stitt, IA Stany, MP Moser, RP Rose, GS Dunlow, SG AF Stitt, Ifeyinwa A. Stany, Michael P. Moser, Richard P., III Rose, G. Scott Dunlow, Susan G. TI Incidental gynecological findings on computed tomographic colonography: Prevalence and outcomes SO GYNECOLOGIC ONCOLOGY LA English DT Article DE CT colonography; Incidental extracolonic findings; Gynecology; Screening; Virtual colonoscopy ID CT COLONOGRAPHY; EXTRACOLONIC FINDINGS; POSTMENOPAUSAL WOMEN; VIRTUAL COLONOSCOPY; NATURAL-HISTORY; ADNEXAL CYSTS; POPULATION AB Objectives. Computed tomographic colonography (CTC) is an investigational method for detecting colorectal polyps. Our objectives were to determine the prevalence of gynecologic findings found incidentally on CTC, and to determine the incidence of additional radiological studies and surgical procedures. Methods. An electronic database identified female patients who underwent CTC at Walter Reed Army Medical Center from January 2002 to July 2005. CTC reports were pared down using gynecologic keywords. Subsequent radiological studies and pathology reports were evaluated for women with gynecological findings. Results. Gynecologic extracolonic findings (ECF) were identified in 71 (9.5%) of the 749 women who underwent CTC. Of these 71 women, 14 (20%) underwent additional radiological and/or surgical evaluation. Nine (13%) of these women underwent surgical evaluation; all pathologic diagnoses were benign. Conclusion. Gynecologic extracolonic findings are common in women undergoing CTC. These gynecologic ECF identified on CTC may lead to additional investigative studies and procedures. Published by Elsevier Inc. C1 [Stitt, Ifeyinwa A.] Martin Army Community Hosp, Dept Obstet & Gynecol, Ft Benning, GA 31905 USA. [Stany, Michael P.; Rose, G. Scott] Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Washington, DC 20307 USA. [Stany, Michael P.; Rose, G. Scott] Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA. [Moser, Richard P., III] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. RP Dunlow, SG (reprint author), 1341 Atwood Rd, Silver Spring, MD 20906 USA. EM susan.dunlow@amedd.army.mil NR 16 TC 6 Z9 6 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD OCT PY 2009 VL 115 IS 1 BP 138 EP 141 DI 10.1016/j.ygyno.2009.05.016 PG 4 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 496IZ UT WOS:000269965700027 PM 19500823 ER PT J AU Reddy, KR Shiffman, ML Rodriguez-Torres, M Abdurakhmanov, D Bakulin, I Silva, GF Cheinquer, H Rabbia, M Depamphilis, J McKenna, M Harrison, SA AF Reddy, K. Rajender Shiffman, Mitchell L. Rodriguez-Torres, Maribel Abdurakhmanov, Djamal Bakulin, Igor Silva, Giovanni Faria Cheinquer, Hugo Rabbia, Michael Depamphilis, Jean McKenna, Michael Harrison, Stephen A. TI STANDARD VERSUS HIGHER INDUCTION DOSES OF PEGINTERFERON ALFA-2A (40KD) AND/OR HIGHER RIBAVIRIN (RBV) IN HCV G1 PATIENTS WITH HIGH VIRAL LOAD AND BODY WEIGHT >= 85 KG: FINAL RESULTS OF THE PROGRESS STUDY SO HEPATOLOGY LA English DT Meeting Abstract CT 60th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases CY OCT 30-NOV 03, 2009 CL Boston, MA SP Amer Assoc Study Liver Dis C1 [Reddy, K. Rajender] Univ Penn, Div Gastroenterol, Philadelphia, PA 19104 USA. [Shiffman, Mitchell L.] Virginia Commonwealth Univ, Med Ctr, Richmond, VA USA. [Rodriguez-Torres, Maribel] Fdn Invest De Diego Santurce, Santurce, PR USA. [Abdurakhmanov, Djamal] Moscow Med Acad, Moscow, Russia. [Bakulin, Igor] Minist Def Russian Federat, State Postgrad Med Inst, Moscow, Russia. [Silva, Giovanni Faria] Botucatu Sch Med, Botucatu, SP, Brazil. [Cheinquer, Hugo] Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil. [Rabbia, Michael; Depamphilis, Jean] Roche, Nutley, NJ USA. [McKenna, Michael] Roche, Welwyn Garden City, England. [Harrison, Stephen A.] Brooke Army Med Ctr, Houston, TX USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2009 VL 50 IS 4 MA 61 BP 330A EP 331A PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 502JV UT WOS:000270456000062 ER PT J AU Harrison, SA Rossaro, L Hu, KQ Patel, K Tillmann, HL Dhaliwal, S Torres, DM Koury, K Goteti, V Brass, CA Noviello, S Albrecht, JK McHutchison, JG Sulkowski, MS AF Harrison, Stephen A. Rossaro, Lorenzo Hu, Ke-Qin Patel, Keyur Tillmann, Hans L. Dhaliwal, Sandeep Torres, Dawn M. Koury, Kenneth Goteti, Venkata Brass, Clifford A. Noviello, Stephanie Albrecht, Janice K. McHutchison, John G. Sulkowski, Mark S. TI RELATIONSHIP OF THE USE OF STATINS AND ELEVATED LOW-DENSITY LIPOPROTEIN (LDL) OR TOTAL CHOLESTEROL (TC) TO VIROLOGIC RESPONSE IN PATIENTS TREATED FOR HEPATITIS C VIRUS (HCV) IN THE IDEAL STUDY SO HEPATOLOGY LA English DT Meeting Abstract CT 60th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases CY OCT 30-NOV 03, 2009 CL Boston, MA SP Amer Assoc Study Liver Dis C1 [Harrison, Stephen A.; Torres, Dawn M.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Rossaro, Lorenzo; Dhaliwal, Sandeep] Univ Calif Davis Hlth Syst, Sacramento, CA USA. [Hu, Ke-Qin; Tillmann, Hans L.] Univ Calif Irvine, Med Ctr, Sacramento, CA USA. [Patel, Keyur; McHutchison, John G.] Duke Clin Res Inst, Durham, NC USA. [Koury, Kenneth; Goteti, Venkata; Brass, Clifford A.; Noviello, Stephanie; Albrecht, Janice K.] Schering Plough Res Inst, Kenilworth, NJ USA. [Sulkowski, Mark S.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. NR 0 TC 5 Z9 5 U1 0 U2 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2009 VL 50 IS 4 MA 120 BP 360A EP 360A PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 502JV UT WOS:000270456000121 ER PT J AU Williams, CD Stengel, JZ Torres, DM Harrison, SA AF Williams, Christopher D. Stengel, Joel Z. Torres, Dawn M. Harrison, Stephen A. TI A PROSPECTIVE PREVALENCE STUDY OF NAFLD AND NASH UTILIZING ULTRASOUND AND LIVER BIOPSY IN A PRIMARY CARE SETTING SO HEPATOLOGY LA English DT Meeting Abstract CT 60th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases CY OCT 30-NOV 03, 2009 CL Boston, MA SP Amer Assoc Study Liver Dis C1 [Williams, Christopher D.; Stengel, Joel Z.; Torres, Dawn M.; Harrison, Stephen A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2009 VL 50 IS 4 MA 975 BP 762A EP 763A PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 502JV UT WOS:000270456000973 ER PT J AU Vierling, JM Hamzeh, FM Lentz, EL Harrison, S AF Vierling, John M. Hamzeh, Fayez M. Lentz, Ellen L. Harrison, Stephen TI VIROLOGIC AND METABOLIC RESPONSES IN CHRONIC HEPATITIS C (CHC) PATIENTS WITH INSULIN RESISTANCE (IR) TREATED WITH PIOGLITAZONE AND PEGINTERFERON ALFA-2A PLUS RIBAVIRIN SO HEPATOLOGY LA English DT Meeting Abstract CT 60th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases CY OCT 30-NOV 03, 2009 CL Boston, MA SP Amer Assoc Study Liver Dis C1 [Vierling, John M.] Baylor Coll Med, Houston, TX 77030 USA. [Hamzeh, Fayez M.; Lentz, Ellen L.] Roche, Nutley, NJ USA. [Harrison, Stephen] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2009 VL 50 IS 4 MA 1571 BP 1028A EP 1029A PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 502JV UT WOS:000270456001566 ER PT J AU Gastaldelli, A Harrison, SA Belfort-Aguilar, R Hardies, LJ Balas, B Schenker, S Cusi, K AF Gastaldelli, Amalia Harrison, Stephen A. Belfort-Aguilar, Renata Hardies, Lou Jean Balas, Bogdan Schenker, Steven Cusi, Kenneth TI Importance of Changes in Adipose Tissue Insulin Resistance to Histological Response During Thiazolidinedione Treatment of Patients with Nonalcoholic Steatohepatitis SO HEPATOLOGY LA English DT Article ID FATTY LIVER-DISEASE; PLACEBO-CONTROLLED TRIAL; PPAR-GAMMA; NONDIABETIC SUBJECTS; DIABETES-MELLITUS; HEPATIC STEATOSIS; HEALTHY-SUBJECTS; ACID METABOLISM; GENE-EXPRESSION; IN-VIVO AB Pioglitazone treatment improves insulin resistance (IR), glucose metabolism, hepatic steatosis, and necroinflammation in patients with nonalcoholic steatohepatitis (NASH). Because abnormal lipid metabolism/elevated plasma free fatty acids (FFAs) are important to the pathophysiology of NASH, we examined the impact of pioglitazone therapy on adipose tissue insulin resistance (Adipo-IR) during the treatment of patients with NASH. To this end, we assessed glucose/lipid metabolism in 47 patients with impaired glucose tolerance/type 2 diabetes mellitus and NASH and 20 nondiabetic controls. All individuals underwent a 75-g oral glucose tolerance test (OGTT) in which we measured glucose tolerance, IR, and suppression of plasma FFAs. We also measured Adipo-IR index (fasting, FFAs X insulin), hepatic fat by magnetic resonance spectroscopy, and liver histology (liver biopsy). Patients were randomized (double-blind) to diet plus pioglitazone (45 mg/day) or placebo for 6 months, and all measurements were repeated. We found that patients with NASH had severe Adipo-IR and low adiponectin levels. Fasting FFAs were increased and their suppression during the OGTT was impaired. Adipo-IR was strongly associated with hepatic fat (r=0.54) and reduced glucose clearance both fasting (r=0.34) and during the OGTT (r=0.40, all P<0.002). Pioglitazone significantly improved glucose tolerance and glucose clearance, steatosis and necroinflammation (all P<0.01-0.001 versus placebo). Fasting/postprandial plasma FFAs decreased to levels of controls with pioglitazone (P<0.02 versus placebo). Adipo-IR decreased by 47% and correlated with the reduction of hepatic fat (r=0.46, P=0.009) and with the reduction in hepatic necroinflammation (r=0.47, P=0.0007). Conclusion: Patients with NASH have severe Adipo-IR independent of the degree of obesity. Amelioration of Adipo-IR by pioglitazone is closely related to histological improvement and plays an important role during treatment of patients with NASH. (HEPATOLOGY 2009;50:1087-1093.) C1 [Gastaldelli, Amalia] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Diabet Div, Audie L Murphy Vet Adm Med Ctr, San Antonio, TX 78248 USA. [Hardies, Lou Jean] Univ Texas Hlth Sci Ctr San Antonio, Dept Radiol, Res Imaging Ctr, San Antonio, TX 78248 USA. [Schenker, Steven] Univ Texas Hlth Sci Ctr San Antonio, Div Gastroenterol, San Antonio, TX 78248 USA. [Gastaldelli, Amalia] CNR, Fdn G Monasterio, Pisa, Italy. [Harrison, Stephen A.] Brooke Army Med Ctr, Div Gastroenterol, San Antonio, TX USA. RP Cusi, K (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Diabet Div, Audie L Murphy Vet Adm Med Ctr, San Antonio, TX 78248 USA. EM cusi@uthscsa.edu RI Hardies, Lou /F-2102-2010; Gastaldelli, Amalia/H-3319-2014 OI Gastaldelli, Amalia/0000-0003-2594-1651 FU NCATS NIH HHS [UL1 TR000149]; NCRR NIH HHS [UL 1RR025767, UL1 RR025767] NR 50 TC 98 Z9 101 U1 0 U2 3 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2009 VL 50 IS 4 BP 1087 EP 1093 DI 10.1002/hep.23116 PG 7 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 502JU UT WOS:000270455800015 PM 19670459 ER PT J AU Fadare, O Rodriguez, R AF Fadare, Oluwole Rodriguez, Rosemarie TI The significance of marked nuclear atypia in grade 1 cervical intraepithelial neoplasia SO HUMAN PATHOLOGY LA English DT Article DE Nuclear atypia; Grade 1 cervical intraepithelial neoplasia; Squamous intraepithelial lesion; Human papillomavirus ID RISK HUMAN-PAPILLOMAVIRUS; NATURAL-HISTORY; FOLLOW-UP; UNDETERMINED SIGNIFICANCE; GENOMIC INSTABILITY; PAPANICOLAOU TEST; SQUAMOUS-CELLS; CANCER; LESIONS; INFECTION AB Approximately 10% to 15% of cases of grade 1 cervical intraepithelial neoplasia are found to have progressed to a high-grade squamous intraepithelial lesion or higher at follow-tip, and there are presently no reliable morphological predictors of this subset. It has recently been reported that cases of grade 1 cervical intraepithelial neoplasia that display marked nuclear atypia (defined as cases with at least 5 epithelial cells with nuclear enlargement of at least 5 times the size of an intermediate cell, and/or multinucleation of at least 5 nuclei.) have a substantially higher rate of high-grade squamous intraepithelial lesion on short-term follow-Lip and may, therefore, require more aggressive initial management. We report herein our experience with a cohort of such cases. After a review of consecutive cervical biopsies, 352 cases with grade 1 cervical intraepithelial neoplasia were classified into group 1 (grade 1 cervical intraepithelial neoplasia with marked atypia, n = 31) and group 2 (grade 1 cervical intraepithelial neoplasia Without marked atypia, n = 321). The average follow-up rates for groups 1 and 2 were 93.55% (29/31) and 90.65% (291/321), respectively. Average follow-up durations were 14.3 and 17.9 months, respectively. The follow-up high-grade squamous intraepithelial lesion rate of the cases with marked atypia was 10.34%, as compared with 11.68% for cases without marked atypia. The follow-up interpretive frequency (in cytologic samples) of "low-grade squamous intraepithelial lesion" was significantly higher in group 1(19/29 versus 114/291, P = .009). However, no significant differences were identified between groups 1 and 2 regarding the interpretive frequencies of either high-grade squamous intraepithelial lesion (3/29 versus 34/291, P = 1) or "negative for intraepithelial lesion or malignancy" (6/29 versus 56/291, P = .8) in follow-tip cytologic samples. In subsets of both groups in which high-risk human papillomavirus testing was performed in the Papanicolaou test sample that immediately preceded the index cervical biopsies, no significant differences in viral load were found. In conclusion, grade 1 cervical intraepithelial neoplasia with marked atypia does not have a higher follow-up high-grade squamous intraepithelial lesion rate than grade 1 cervical intraepithelial neoplasia without marked atypia in our patient population. Further studies are required to address the significance of marked atypia in grade 1 cervical intraepithelial neoplasia and whether patients with this finding should be managed differently. Published by Elsevier Inc. C1 [Fadare, Oluwole] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX 78236 USA. [Fadare, Oluwole] Wilford Hall USAF Med Ctr, Dept Pathol, San Antonio, TX 78236 USA. [Rodriguez, Rosemarie] Brooke Army Med Ctr, Dept Pathol, San Antonio, TX 78236 USA. RP Fadare, O (reprint author), Vanderbilt Univ, Med Ctr, Dept Pathol, 1161 21st Ave S,MCN, Nashville, TN 37232 USA. EM oluwolefadare@yahoo.com NR 31 TC 1 Z9 1 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0046-8177 J9 HUM PATHOL JI Hum. Pathol. PD OCT PY 2009 VL 40 IS 10 BP 1487 EP 1493 DI 10.1016/j.humpath.2009.03.015 PG 7 WC Pathology SC Pathology GA 498TM UT WOS:000270166200017 PM 19540559 ER PT J AU Suri, N Benvegnu, E Tortonesi, M Stefanelli, C Kovach, J Hanna, J AF Suri, Niranjan Benvegnu, Erika Tortonesi, Mauro Stefanelli, Cesare Kovach, Jesse Hanna, James TI Communications Middleware for Tactical Environments: Observations, Experiences, and Lessons Learned SO IEEE COMMUNICATIONS MAGAZINE LA English DT Article AB Tactical networking environments present significant challenges that must be overcome in order to effectively support net-centric warfare. The wireless and ad hoc nature of these networks implies unreliable connectivity, limited bandwidth, and variable latency. Past and current research has focused on physical and data link layers, routing protocols, transport protocols, and cross-layer aspects. However, significant work is needed at the upper layers to better support application requirements. In our experience, achieving effective communications in tactical environments requires taking into account application requirements and communication patterns, designing a rich interface between the application and communication layers, and realizing a communications middleware specifically adapted to tactical networks. In this article, we report on our observations from several tactical networking experiments and demonstrations and the lessons learned from deployment of the Mockets middleware to support tactical communications. We hope these experiences are useful to others designing and implementing applications and systems for tactical environments. C1 [Stefanelli, Cesare] Univ Ferrara, Dept Engn, I-44100 Ferrara, Italy. [Kovach, Jesse] USA, Res Lab, Battlefield Informat Proc Branch, Washington, DC USA. [Hanna, James] USAF, Res Lab, Enterprise Informat Management Branch, Informat Directorate, Wright Patterson AFB, OH USA. EM nsuri@ihmc.us; mauro.tortonesi@unife.it; ebenvegnu@ihmc.us; cesare.stefanelli@unife.it; jkovach@arl.army.mil; james.hanna@rl.af.mil OI Tortonesi, Mauro/0000-0002-7417-4455 FU U.S. Army Research Laboratory [W911NF-04-2-0013, DAAD19-01-2-0009]; Air Force Research Laboratory [FA8750-06-2-0064] FX This research was sponsored in part by the U.S. Army Research Laboratory under Cooperative Agreement W911NF-04-2-0013, by the U. S. Army Research Laboratory under the Collaborative Technology Alliance Program, Cooperative Agreement DAAD19-01-2-0009, and by the Air Force Research Laboratory under Cooperative Agreement FA8750-06-2-0064. Figure 1 is courtesy of the Northrop-Grumman Corporation, Melbourne, FL. NR 12 TC 12 Z9 12 U1 1 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0163-6804 EI 1558-1896 J9 IEEE COMMUN MAG JI IEEE Commun. Mag. PD OCT PY 2009 VL 47 IS 10 BP 56 EP 63 DI 10.1109/MCOM.2009.5273809 PG 8 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 503OW UT WOS:000270548300007 ER PT J AU Younis, O Kant, L Chang, K Young, K Graff, C AF Younis, Ossama Kant, Latha Chang, Kirk Young, Kenneth Graff, Charles TI Cognitive MANET Design for Mission-Critical Networks SO IEEE COMMUNICATIONS MAGAZINE LA English DT Article DE Mobile ad hoc networks; Topology; Routing; Bandwidth; Layout; Data mining; Optimization AB For mobile ad hoc networks used in network-centric operations, there is a growing need for a systematic methodology for analyzing/predicting the performance of the network over the mission duration. With the advance in cognitive networking as a possible means of exploiting unused spectrum, there is now a growing need to study how to design a cognitive network using an automated methodology. In this article we study the concepts and challenges for automatic design/reconfiguration of cognitive MANETs. We describe the design objectives, imposed constraints, and involved parameters in MANETs. We describe how cognitive techniques can be employed to exploit the unused spectrum in military architectures. We then discuss the challenges facing the design/reconfiguration of a cognitive network and their implications at different network layers. We also describe possible implementation options for designing MANETs that employ cognitive features at all layers. C1 [Younis, Ossama; Kant, Latha] Telcordia Technol Inc, Mobile Networking Res Dept, Piscataway, NJ USA. [Chang, Kirk] Telcordia Technol Inc, Appl Res Area, Piscataway, NJ USA. [Young, Kenneth] Telcordia Technol Inc, Appl Res Org, Govt Project Dev, Piscataway, NJ USA. [Graff, Charles] USA, CERDEC, Washington, DC USA. RP Younis, O (reprint author), Telcordia Technol Inc, Mobile Networking Res Dept, Piscataway, NJ USA. EM oyounis@research.telcordia.com FU CERDEC [DAAD-19-01-C-0062] FX The work in this article was made possible from the funding of the Network Design Project from CERDEC under contract DAAD-19-01-C-0062, Task Order 14. NR 10 TC 15 Z9 16 U1 1 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0163-6804 J9 IEEE COMMUN MAG JI IEEE Commun. Mag. PD OCT PY 2009 VL 47 IS 10 BP 64 EP 71 DI 10.1109/MCOM.2009.5273810 PG 8 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 503OW UT WOS:000270548300008 ER PT J AU White, JO AF White, Jeffrey Owen TI Parameters for Quantitative Comparison of Two-, Three-, and Four-Level Laser Media, Operating Wavelengths, and Temperatures SO IEEE JOURNAL OF QUANTUM ELECTRONICS LA English DT Article DE Erbium lasers; holmium lasers; laser physics; neodymium lasers; quasi-four-level lasers; quasi-three-level lasers; quasi-two-level lasers ID ND-YAG LASER; QUASI-3-LEVEL LASERS; 946 NM; CONTINUOUS-WAVE; PUMPED LASER; SWITCHED LASERS; EMITTING LEVEL; UP-CONVERSION; CW THEORY; ENERGY AB Several parameters are proposed for describing the statistical thermodynamic component of the exchange of photons between a pump and a laser beam. They are based on the occupation probability of absorbing and emitting, pump and laser levels, and are complementary to the optical cross sections. The "occupation factor," f(0) appropriate for describing an optical amplifier in the small signal regime. f(1) is appropriate for describing an amplifier in the large signal regime, e.g., a laser. They serve to facilitate a quantitative comparison of laser gain media, operating temperatures, and choice of pump and laser wavelengths. After a simple scaling, both occupation factors have a numerical value that coincides well, in most cases, with conventional usage of the terms two-, three-, and four- level laser. They can thus serve as an unambiguous, quantitative alternative to the quasi-two-, quasi-three-, and quasi-four-level terminology. The proposed definitions are general enough to apply to many types of gain media, but are particularly useful for comparing systems with discrete levels, pumped with a narrowband source, in near-resonance with the laser wavelength. Several low-quantum-defect combinations of pump and laser wavelengths are analyzed for Er(3+), Nd(3+), Yb(3+), and Ho(3+) in YAG, as a function of temperature. C1 USA, Res Lab, Electroopt & Photon Div, Adelphi, MD 20783 USA. RP White, JO (reprint author), USA, Res Lab, Electroopt & Photon Div, Adelphi, MD 20783 USA. EM jeffrey.owen.white@arl.army.mil NR 38 TC 7 Z9 7 U1 1 U2 18 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9197 J9 IEEE J QUANTUM ELECT JI IEEE J. Quantum Electron. PD OCT PY 2009 VL 45 IS 10 BP 1213 EP 1220 DI 10.1109/JQE.2009.2020607 PG 8 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA 498NE UT WOS:000270147000001 ER PT J AU Choi, KK Forrai, DP Endres, DW Sun, J AF Choi, Kwong-Kit Forrai, David P. Endres, Darrel W. Sun, Jason TI Corrugated Quantum-Well Infrared Photodetector Focal Plane Arrays SO IEEE JOURNAL OF QUANTUM ELECTRONICS LA English DT Article DE Focal plane array; infrared detector; quantum efficiency ID PERFORMANCE AB Corrugated quantum-well infrared photodetectors (C-QWIPs) have been proposed for long-wavelength infrared detection. In this work, we optimize the detector structure and produce a number of large format focal plane arrays (FPAs). Specifically, we adopt one-corrugation-per-pixel geometry to increase the active detector volume and incorporate a composite cover layer to preserve the large sidewall reflectivity, which results in a large detector quantum efficiency. We also optimize the detector material structure such as the final state energy, the doping density, and the number of quantum well periods to improve the FPA operation under the existing readout electronics. As a result, high FPA sensitivity has been achieved, and their characteristics are in agreement with the detector model. Based on this model, we perform a systematic analysis on the FPA performance with a wide range of detector and system parameters. We find that C-QWIP FPAs are capable of high-speed imaging especially for those with longer cutoff wavelengths. C1 [Choi, Kwong-Kit; Sun, Jason] USA, Res Lab, Adelphi, MD 20783 USA. [Forrai, David P.; Endres, Darrel W.] L3 Cincinnati Elect, Mason, OH 45040 USA. RP Choi, KK (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM kchoi@arl.army.mil; Dave.Forrai@L-3Com.com; Darrel.Endres@L-3Com.com; jason.sun@arl.army.mil RI Choi, Kwong-Kit/K-9205-2013 NR 13 TC 19 Z9 19 U1 0 U2 10 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9197 J9 IEEE J QUANTUM ELECT JI IEEE J. Quantum Electron. PD OCT PY 2009 VL 45 IS 10 BP 1255 EP 1264 DI 10.1109/JQE.2009.2026185 PG 10 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA 499JH UT WOS:000270215400001 ER PT J AU Perlman, B AF Perlman, Barry TI Constant Change SO IEEE MICROWAVE MAGAZINE LA English DT Editorial Material C1 [Perlman, Barry] USA, RDECOM, CERDEC, DARPA Program, Ft Monmouth, NJ 07703 USA. [Perlman, Barry] USA, RDECOM, CERDEC, HPC Program, Ft Monmouth, NJ 07703 USA. RP Perlman, B (reprint author), USA, RDECOM, CERDEC, DARPA Program, Ft Monmouth, NJ 07703 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1527-3342 J9 IEEE MICROW MAG JI IEEE Microw. Mag. PD OCT PY 2009 VL 10 IS 6 BP 14 EP 24 DI 10.1109/MMM.2009.933587 PG 5 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 494TJ UT WOS:000269839800004 ER PT J AU Dorsey, WM Zaghloul, AI AF Dorsey, W. Mark Zaghloul, Amir I. TI Dual-Substrate Capacitive Loading for Size Reduction in Shorted Annular Ring Antennas SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Article DE Capacitive loading; printed circuit antennas; shorted annular ring; size reduction AB This communication presents a capacitive loading technique capable of providing significant size reduction in shorted annular ring antennas. Capacitive loading techniques are utilized in many antenna geometries to reduce the size of the radiator. Many such structures generate capacitance between parallel conducting planes. The new loading structure utilizes two separate microwave substrates. One substrate is contained beneath the radiator, and a high dielectric substrate is present between the parallel conductors to increase the capacitive effect. The new loading technique is verified with simulations and measurements with excellent agreement between the two. C1 [Dorsey, W. Mark; Zaghloul, Amir I.] Virginia Polytech Inst & State Univ, Blacksburg, VA 24061 USA. [Dorsey, W. Mark] USN, Res Lab, Div Radar, Washington, DC 20375 USA. [Zaghloul, Amir I.] USA, Res Lab, Adelphi, MD 20783 USA. RP Dorsey, WM (reprint author), Virginia Polytech Inst & State Univ, Blacksburg, VA 24061 USA. EM dorsey@radar.nrl.navy.mil; amirz@vt.edu NR 14 TC 2 Z9 2 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-926X J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD OCT PY 2009 VL 57 IS 10 BP 3339 EP 3342 DI 10.1109/TAP.2009.2029391 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 505UP UT WOS:000270723600047 ER PT J AU Miao, GW Li, GY Swami, A AF Miao, Guowang Li, Geoffrey Ye Swami, Ananthram TI Decentralized Optimization for Multichannel Random Access SO IEEE TRANSACTIONS ON COMMUNICATIONS LA English DT Article DE Cross-layer; decentralized; random access; multichannel; channel aware ID CROSS-LAYER DESIGN; OFDM WIRELESS NETWORKS; AD HOC NETWORKS; FADING CHANNELS; PROPORTIONAL FAIRNESS; ALOHA; INFORMATION; STABILITY AB We consider schemes for decentralized cross-layer optimization of multichannel random access by exploiting local channel state and traffic information. In the network we are considering, users are not necessarily within the transmission ranges of all others; therefore, when a user is transmitting, it may only interfere with some users, which is different from most existing channel aware Aloha schemes. Besides, we also consider complicated traffic distribution, e.g. each user may choose to send packets to or receive packets from different users simultaneously. We develop decentralized optimization for multichannel random access (DOMRA). DOMRA consists of three steps: neighborhood information collection, transmission control of the MAC layer based on the instantaneous channel state information, and power allocation for each traffic flow on each subchannel. Simulation results demonstrated that DOMRA significantly outperforms existing channel aware Aloha schemes due to its exploitation of both multiuser diversity through cross-layer design and the inhomogeneous characteristics of traffic spatial distribution in the network. Besides, DOMRA performs closely to the globally optimum solution, which requires full network knowledge to be obtained. DOMRA can be applied to different types of wireless networks, such as wireless sensor networks and mobile ad hoc networks, to improve quality of service. C1 [Miao, Guowang; Li, Geoffrey Ye] Georgia Inst Technol, Sch Elect & Comp Engn, Atlanta, GA 30332 USA. [Swami, Ananthram] USA, Res Lab, CISD, Adelphi, MD 20783 USA. RP Miao, GW (reprint author), Georgia Inst Technol, Sch Elect & Comp Engn, Atlanta, GA 30332 USA. EM gmiao3@gatech.edu; liye@ece.gatech.edu; a.swami@ieee.org FU Intel; U.S. Army Research Laboratory under the Collaborative Technology Alliance Program, Cooperative Agreement [DAAD19-01-20-0011]; SABA Program of Motorola FX This work was supported by a research gift from Intel, the U.S. Army Research Laboratory under the Collaborative Technology Alliance Program, Cooperative Agreement DAAD19-01-20-0011, and the SABA Program of Motorola. Part of this work was published at Globecom 2007. NR 34 TC 7 Z9 7 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0090-6778 J9 IEEE T COMMUN JI IEEE Trans. Commun. PD OCT PY 2009 VL 57 IS 10 BP 3012 EP 3023 DI 10.1109/TCOMM.2009.10.080167 PG 12 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 508DU UT WOS:000270908700028 ER PT J AU Cecchi, V Leger, AS Miu, K Nwankpa, CO AF Cecchi, Valentina Leger, Aaron St. Miu, Karen Nwankpa, Chika O. TI Modeling Approach for Transmission Lines in the Presence of Non-Fundamental Frequencies SO IEEE TRANSACTIONS ON POWER DELIVERY LA English DT Article DE Hardware laboratory; harmonic power flow; non-fundamental frequencies; transmission-line modeling AB This paper presents a transmission-line modeling tool to obtain a desired level of accuracy at non-fundamental frequencies. Specifically, the approach compares finitely segmented models to the uniformly distributed model in order to determine the appropriate segmentation of the line model for a desired frequency range. The line model performance is characterized through waveform propagation, including attenuation and phase shift. The software-based modeling tool is validated through hardware tests of different segmentations. C1 [Cecchi, Valentina; Miu, Karen; Nwankpa, Chika O.] Drexel Univ, Dept Elect & Comp Engn, Philadelphia, PA 19104 USA. [Leger, Aaron St.] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10566 USA. RP Cecchi, V (reprint author), Drexel Univ, Dept Elect & Comp Engn, Philadelphia, PA 19104 USA. EM vc26@drexel.edu; aaron.stleger@usma.edu; karen@ece.drexel.edu; con22@drexel.edu FU ONR [N0014-04-1-0404] FX Manuscript received November 26, 2007; revised April 03, 2008. Current version published September 23, 2009. This work was supported by ONR N0014-04-1-0404. Paper no. TPWRD-00741-2007. NR 23 TC 8 Z9 9 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0885-8977 J9 IEEE T POWER DELIVER JI IEEE Trans. Power Deliv. PD OCT PY 2009 VL 24 IS 4 BP 2328 EP 2335 DI 10.1109/TPWRD.2008.2002876 PG 8 WC Engineering, Electrical & Electronic SC Engineering GA 498KV UT WOS:000270139900066 ER PT J AU Hughes, MA Burns, DL Juris, SJ Tang, WJ Clement, KH Eaton, LJ Kelly-Cirino, CD Mckee, ML Powell, BS Bishop, BL Rudge, TL Shine, N Verma, A Willis, MS Morse, SA AF Hughes, Molly A. Burns, Drusilla L. Juris, Stephen J. Tang, Wei-Jen Clement, Kristin H. Eaton, Linda J. Kelly-Cirino, Cassandra D. McKee, Marian L. Powell, Bradford S. Bishop, Brian L. Rudge, Thomas L. Shine, Nancy Verma, Anita Willis, Melissa Swope Morse, Stephen A. TI The Case for Developing Consensus Standards for Research in Microbial Pathogenesis: Bacillus anthracis Toxins as an Example SO INFECTION AND IMMUNITY LA English DT Editorial Material ID PUBLIC-HEALTH MANAGEMENT; RESISTANT STAPHYLOCOCCUS-AUREUS; LETHAL TOXIN; BIOLOGICAL WEAPON; TRANSCRIPTIONAL RESPONSES; MURINE MACROPHAGES; GENE ONTOLOGY; EDEMA TOXIN; CELL-TYPE; A TOXIN C1 [Hughes, Molly A.] Univ Virginia Hlth Sci Syst, Dept Med, Div Infect Dis, Charlottesville, VA 22908 USA. [Burns, Drusilla L.; Verma, Anita] US FDA, Lab Resp & Special Pathogens Ctr, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA. [Juris, Stephen J.] Cent Michigan Univ, Dept Biol, Mt Pleasant, MI 48859 USA. [Juris, Stephen J.] Cent Michigan Univ, Dept Chem, Mt Pleasant, MI 48859 USA. [Tang, Wei-Jen; Bishop, Brian L.] Univ Chicago, Ctr Integrat Sci, Ben May Dept Canc Res, Chicago, IL 60637 USA. [Clement, Kristin H.; Rudge, Thomas L.] Battelle Biomed Res Ctr, Battelle Mem Inst, W Jefferson, OH 43162 USA. [Eaton, Linda J.; Shine, Nancy] List Biol Labs Inc, Campbell, CA 95008 USA. [Kelly-Cirino, Cassandra D.] New York State Dept Hlth, Wadsworth Ctr, Div Infect Dis, Biodefense Lab,David Axelrod Inst, Albany, NY 12201 USA. [McKee, Marian L.; Willis, Melissa Swope] ATCC, Manassas, VA 20110 USA. [Powell, Bradford S.] USA, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21702 USA. [Morse, Stephen A.] Ctr Dis Control & Prevent, Div Bioterrorism Preparedness & Response, Natl Ctr Preparedness Detect & Control Infect Dis, Atlanta, GA 30333 USA. RP Hughes, MA (reprint author), Univ Virginia Hlth Syst, Dept Med, Div Infect Dis & Int Hlth, POB 800513, Charlottesville, VA 22908 USA. EM mah3x@virginia.edu OI Tang, Wei-Jen/0000-0002-8267-8995; Kelly-Cirino, Cassandra/0000-0002-4526-8487 NR 31 TC 2 Z9 2 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD OCT PY 2009 VL 77 IS 10 BP 4182 EP 4186 DI 10.1128/IAI.00368-09 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 496ER UT WOS:000269952800002 PM 19651858 ER PT J AU Zelazny, AM Ding, L Elloumi, HZ Brinster, LR Benedetti, F Czapiga, M Ulrich, RL Ballentine, SJ Goldberg, JB Sampaio, EP Holland, SM AF Zelazny, Adrian M. Ding, Li Elloumi, Houda Z. Brinster, Lauren R. Benedetti, Fran Czapiga, Meggan Ulrich, Ricky L. Ballentine, Samuel J. Goldberg, Joanna B. Sampaio, Elizabeth P. Holland, Steven M. TI Virulence and Cellular Interactions of Burkholderia multivorans in Chronic Granulomatous Disease SO INFECTION AND IMMUNITY LA English DT Article ID RESPIRATORY EPITHELIAL-CELLS; CEPACIA COMPLEX; CYSTIC-FIBROSIS; HOST-DEFENSE; INTRACELLULAR SURVIVAL; PSEUDOMONAS-CEPACIA; LUNG INFECTION; GENE-TRANSFER; MURINE MODEL; IN-VITRO AB Chronic granulomatous disease (CGD) patients are susceptible to life-threatening infections by the Burkholderia cepacia complex. We used leukocytes from CGD and healthy donors and compared cell association, invasion, and cytokine induction by Burkholderia multivorans strains. A CGD isolate, CGD1, showed higher cell association than that of an environmental isolate, Env1, which correlated with cell entry. All B. multivorans strains associated significantly more with cells from CGD patients than with those from healthy donors. Similar findings were observed with another CGD pathogen, Serratia marcescens, but not with Escherichia coli. In a mouse model of CGD, strain CGD1 was virulent while Env1 was avirulent. B. multivorans organisms were found in the spleens of CGD1-infected mice at levels that were 1,000 times higher than those found in Env1-infected mice, which was coincident with higher levels of the proinflammatory cytokine interleukin-1 beta. Taken together, these results may shed light on the unique susceptibility of CGD patients to specific pathogens. C1 [Zelazny, Adrian M.] NIH, Microbiol Serv, Dept Lab Med, Ctr Clin, Bethesda, MD 20892 USA. [Zelazny, Adrian M.; Ding, Li; Elloumi, Houda Z.; Ballentine, Samuel J.; Sampaio, Elizabeth P.; Holland, Steven M.] NIAID, Lab Clin Infect Dis, Bethesda, MD 20892 USA. [Brinster, Lauren R.; Benedetti, Fran] NIAID, Div Vet Resources, Bethesda, MD 20892 USA. [Czapiga, Meggan] NIAID, Biol Imaging Sect, Bethesda, MD 20892 USA. [Ulrich, Ricky L.] USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. [Goldberg, Joanna B.] Univ Virginia Hlth Syst, Dept Microbiol, Charlottesville, VA USA. [Sampaio, Elizabeth P.] Fiocruz MS, Leprosy Lab, Inst Oswaldo Cruz, BR-21045900 Rio De Janeiro, Brazil. RP Zelazny, AM (reprint author), NIH, Microbiol Serv, Dept Lab Med, Ctr Clin, 10 Ctr Dr,Bldg 10-2C-385, Bethesda, MD 20892 USA. EM azelazny@mail.nih.gov FU Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health FX This work was financially supported by the Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health. NR 46 TC 12 Z9 13 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD OCT PY 2009 VL 77 IS 10 BP 4337 EP 4344 DI 10.1128/IAI.00259-09 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 496ER UT WOS:000269952800017 PM 19635825 ER PT J AU Murhandarwati, EEH Wang, LN Black, CG Nhan, DH Richie, TL Coppel, RL AF Murhandarwati, E. Elsa Herdiana Wang, Lina Black, Casilda G. Nhan, Doan Hanh Richie, Thomas L. Coppel, Ross L. TI Inhibitory Antibodies Specific for the 19-Kilodalton Fragment of Merozoite Surface Protein 1 Do Not Correlate with Delayed Appearance of Infection with Plasmodium falciparum in Semi-Immune Individuals in Vietnam SO INFECTION AND IMMUNITY LA English DT Article ID C-TERMINAL FRAGMENT; MALARIA MORBIDITY; 19-KDA FRAGMENT; PARASITE GROWTH; BLOOD STAGES; MECHANISMS; PROTECTION; RESPONSES; CHILDREN; ANTIGEN AB Inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein 1 (MSP1(19)) are a significant component of inhibitory responses in individuals immune to malaria. Nevertheless, conflicting results have been obtained in determining whether this antibody specificity correlates with protection in residents of areas where malaria is endemic. In this study, we examined sera collected from a population of semi-immune individuals living in an area of Vietnam with meso-endemicity during a 6-month period. We used two Plasmodium falciparum parasite lines that express either endogenous MSP1(19) or the homologous region from Plasmodium yoelii to measure the MSP1(19)-specific inhibitory activity. We showed that (i) the level of MSP1(19)-specific inhibitory antibodies was not associated with a delay in P. falciparum infection, (ii) MSP1(19)-specific inhibitory antibodies declined significantly during the convalescent period after infection, and (iii) there was no significant correlation between the MSP1(19)-specific inhibitory antibodies and the total antibodies measured by enzyme-linked immunosorbent assay. These results have implications for understanding naturally acquired immunity to malaria and for the development and evaluation of MSP1(19)-based vaccines. C1 [Murhandarwati, E. Elsa Herdiana; Wang, Lina; Black, Casilda G.; Coppel, Ross L.] Monash Univ, Dept Microbiol, Clayton, Vic 3800, Australia. [Nhan, Doan Hanh] Inst Malariol Parasitol & Entomol, Hanoi, Vietnam. [Richie, Thomas L.] USN, US Mil Malaria Vaccine Program, Med Res Ctr, Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Coppel, RL (reprint author), Monash Univ, Dept Microbiol, Clayton, Vic 3800, Australia. EM ross.coppel@med.monash.edu.au RI Richie, Thomas/A-8028-2011; Coppel, Ross/A-6626-2008; Black, Casilda/B-1519-2008 OI Coppel, Ross/0000-0002-4476-9124; Richie, Thomas/0000-0002-2946-5456; Black, Casilda/0000-0002-0424-4593 FU National Health and Medical Research Council (NHMRC) of Australia; National Institutes of Health [DK-32094]; AusAID scholarship FX This work was supported by the National Health and Medical Research Council (NHMRC) of Australia and the National Institutes of Health (grant DK-32094). The field component of this study was conducted as a collaboration between the Institute for Malariology, Parasitology and Entomology, Hanoi, Vietnam, and U. S. Naval Medical Research Unit 2, Jakarta, Indonesia, in accordance with U. S. Navy regulations governing the protection of human subjects in medical research. E. E. H. M. is a recipient of an AusAID scholarship. NR 33 TC 14 Z9 14 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD OCT PY 2009 VL 77 IS 10 BP 4510 EP 4517 DI 10.1128/IAI.00360-09 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 496ER UT WOS:000269952800037 PM 19620342 ER PT J AU Tran, DT Chu, D Oliver, AG Oliver, SRJ AF Tran, Dat T. Chu, Deryn Oliver, Allen G. Oliver, Scott R. J. TI A 3-D bismuth-organic framework containing 1-D cationic inorganic [Bi2O2]2(+) chains SO INORGANIC CHEMISTRY COMMUNICATIONS LA English DT Article DE Metal-organic framework; Hydrothermal synthesis; 3,5-Pyridinedicarboxylate; 1-D bismuth oxide chains; 1-D extended inorganic chains; Bismuth-organic framework ID COMPLEXES; LIGANDS; CARBOXYLATES; CHEMISTRY; IDENTIFICATION AB A three-dimensional Bi(III) based metal-organic framework was synthesized under hydrothermal conditions using the multidentate organic linker 3,5-pyridinedicarboxylate. Bismuth oxide 3,5-pyridinedicarboxylate, Bi2O2[NC5H3(CO2)(2)], contains embedded 1-D cationic bismuth oxide chains that propagate along the crystallographic c-axis. The oxygens of the Bi2O2 core are three-coordinate and bond strongly to the Bi atoms. Thermogravimetric analysis shows that the material possesses high thermal stability up ca. 400 degrees C before decomposing to phase-pure Bi2O3 at 800 degrees C. The structure, crystallinity, morphology and properties of the material are discussed. Published by Elsevier B.V. C1 [Tran, Dat T.; Chu, Deryn] USA, Res Lab, Adelphi, MD 20783 USA. [Oliver, Allen G.; Oliver, Scott R. J.] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA. RP Tran, DT (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM dat.tran1@arl.army.mil FU Army Research Laboratory; NSF [DMR-0506279)]; US Department of Energy, Office of Energy Sciences [DE-AC02-05CH11231] FX The Army Research Laboratory is acknowledged for financial support of this research. S.O. acknowledges financial support from an NSF Career Award (DMR-0506279). Samples for synchrotron crystallographic analysis were submitted through the SCrALS (Service Crystallography at Advanced Light Source) program. The ALS is supported by the US Department of Energy, Office of Energy Sciences, under contract DE-AC02-05CH11231. NR 29 TC 11 Z9 11 U1 3 U2 24 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1387-7003 J9 INORG CHEM COMMUN JI Inorg. Chem. Commun. PD OCT PY 2009 VL 12 IS 10 BP 1081 EP 1084 DI 10.1016/j.inoche.2009.08.030 PG 4 WC Chemistry, Inorganic & Nuclear SC Chemistry GA 513XB UT WOS:000271356300040 ER PT J AU Garg, P Alvarado, JL Marsh, C Carlson, TA Kessler, DA Annamalai, K AF Garg, Paritosh Alvarado, Jorge L. Marsh, Charles Carlson, Thomas A. Kessler, David A. Annamalai, Kalyan TI An experimental study on the effect of ultrasonication on viscosity and heat transfer performance of multi-wall carbon nanotube-based aqueous nanofluids SO INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER LA English DT Article DE Convective heat transfer; Nanofluids; Multi-walled; Carbon nanotubes; Thermal conductivity; Viscosity; Heat transfer enhancement; Non-Newtonian fluid; TEM ID THERMAL-CONDUCTIVITY ENHANCEMENT; LAMINAR-FLOW; SUSPENSIONS; PARTICLES; FLUIDS; WATER AB Four samples of 1 wt% multi-walled carbon nanotube-based (MWCNT) aqueous nanofluids prepared via ultrasonication were thermally characterized. Direct imaging was done using a newly developed wet-TEM technique to assess the dispersion state of carbon nanotubes (CNT) in suspension. The effect of dispersing energy (ultrasonication) on viscosity, thermal conductivity, and the laminar convective heat transfer was studied. Results indicate that thermal conductivity and heat transfer enhancement increased until an optimum ultrasonication time was reached, and decreased on further ultrasonication. The suspensions exhibited a shear thinning behavior, which followed the Power Law viscosity model. The maximum enhancements in thermal conductivity and convective heat transfer were found to be 20% and 32%, respectively. The thermal conductivity enhancement increased considerably at temperatures greater than 24 degrees C. The enhancement in convective heat transfer was found to increase with axial distance. A number of mechanisms related to boundary layer thickness, micro-convective effect, particle rearrangement, possible induced convective effects due to temperature and viscosity variations in the radial direction, and the non-Newtonian nature of the samples are discussed. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Alvarado, Jorge L.] Texas A&M Univ, Dept Engn Technol & Ind Distribut, College Stn, TX 77843 USA. [Garg, Paritosh; Annamalai, Kalyan] Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. [Marsh, Charles; Carlson, Thomas A.] USA, Ctr Res Dev & Engn, Construct Engn Res Lab, Champaign, IL 61822 USA. [Marsh, Charles] Dept Nucl Plasma & Radiol Engn, Urbana, IL 61801 USA. [Kessler, David A.] USN, Res Lab, Computat Phys & Fluid Dynam Lab, Washington, DC 20375 USA. RP Alvarado, JL (reprint author), Texas A&M Univ, Dept Engn Technol & Ind Distribut, 117 Thompson Hall,3367 TAMU, College Stn, TX 77843 USA. EM alvarado@entc.tamu.edu OI Alvarado, Jorge/0000-0002-4059-6588 FU National Science Foundation; SBIR/STTR; U.S. Army Corps of Engineers FX The authors express their deepest thanks to Alex Hays and Ryan Franks of the U.S. Army Corps of Engineers Construction Engineering Research Laboratory: Guillermo Soriano and Landon Sommer from Texas A&M University: Professor B. Jones of the Nuclear, Plasma, and Radiological Engineering Department, and Jianguo Wen, Dongxiang Liao of the Frederick Seitz Materials Research Laboratory at the University of Illinois at Urbana-Champaign for their Support. The project was supported by the National Science Foundation, SBIR/STTR program, and the U.S. Army Corps of Engineers. NR 32 TC 186 Z9 187 U1 5 U2 27 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0017-9310 J9 INT J HEAT MASS TRAN JI Int. J. Heat Mass Transf. PD OCT PY 2009 VL 52 IS 21-22 BP 5090 EP 5101 DI 10.1016/j.ijheatmasstransfer.2009.04.029 PG 12 WC Thermodynamics; Engineering, Mechanical; Mechanics SC Thermodynamics; Engineering; Mechanics GA 498SS UT WOS:000270164200047 ER PT J AU Orphal, DL Anderson, CE Behner, T Templeton, DW AF Orphal, Dennis L. Anderson, Charles E., Jr. Behner, Thilo Templeton, Douglas W. TI Failure and penetration response of borosilicate glass during multiple short-rod impact SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Failure wave; Failure front; Damage propagation; Borosilicate glass; Rod impact AB In Anderson Jr CE, Orphal DL, Behner T, Templeton, DW [Failure and penetration response of borosilicate glass during short-rod impact. Int J Impact Eng 2009, doi:10.1016/j.ijimpeng.2008.12.002.1 it was demonstrated that the failure front (FF) produced by the penetration of a borosilicate glass target by a gold rod ceased to propagate a short time after the rod was fully eroded. This strongly suggests that progression of the FF is not described by a wave equation. Here it is shown that propagation of the FF is reinitiated if a second co-axial rod, spaced a distance from the first, impacts the glass at the bottom of the penetration channel. The experiments were performed in reverse ballistic mode with two short rods spaced apart. In some experiments both rods were gold; in other experiments, one rod was copper and the other gold. FF propagation was measured using high-speed photography; rod penetration was measured using multiple, independent flash X-rays. Much of the observed phenomenology can be modeled assuming that the rod, either first or second, "communicates" with the FF at a speed corresponding to the bulk sound speed of the undamaged glass. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Orphal, Dennis L.] Int Res Associates Inc, Pleasanton, CA 94566 USA. [Anderson, Charles E., Jr.] SW Res Inst, San Antonio, TX 78228 USA. [Behner, Thilo] Ernst Mach Inst, Fraunhofer Inst Kurzzeitdynam, D-79104 Freiburg, Germany. [Templeton, Douglas W.] USA, RDECOM TACOM, AMST TR R, Warren, MI 48397 USA. RP Orphal, DL (reprint author), Int Res Associates Inc, 4450 Black Ave, Pleasanton, CA 94566 USA. EM dorphal@aol.com NR 10 TC 7 Z9 7 U1 1 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD OCT-NOV PY 2009 VL 36 IS 10-11 BP 1173 EP 1181 DI 10.1016/j.ijimpeng.2009.05.008 PG 9 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 481XJ UT WOS:000268845900001 ER PT J AU Wright, TW Ramesh, KT AF Wright, T. W. Ramesh, K. T. TI Statistically informed dynamics of void growth in rate dependent materials SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Spall; Voids; Nucleation; Growth; Local inertia; Rate dependence ID CAVITATION; SOLIDS AB An inherently rate dependent material model is used to model the nucleation and growth of voids in metals, leading to spall fracture. Intrinsic material rate dependence introduces a third time scale in addition to those introduced by rates of nucleation and growth. Material rate dependence does increase the spall strength of metals, but it is not nearly as important as local inertia in doing so. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Ramesh, K. T.] Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. [Wright, T. W.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Ramesh, KT (reprint author), Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. EM ramesh@jhu.edu NR 12 TC 12 Z9 12 U1 1 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD OCT-NOV PY 2009 VL 36 IS 10-11 BP 1242 EP 1249 DI 10.1016/j.ijimpeng.2009.05.007 PG 8 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 481XJ UT WOS:000268845900008 ER PT J AU Wang, X Pan, E Chung, PW AF Wang, X. Pan, E. Chung, P. W. TI Some basic problems in anisotropic bimaterials with a viscoelastic interface SO INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES LA English DT Article DE Anisotropy; Viscoelastic interface; Green's function; Inclusion; Crack ID HALF-PLANES; SCREW DISLOCATION; ARBITRARY SHAPE; ESHELBY PROBLEM; ELASTIC FIELDS; INCLUSION AB This research is devoted to the study of anisotropic bimaterials with Kelvin-type viscoelastic interface under antiplane deformations. First we derive the Green's function for a bimaterial with a Kelvin-type viscoelastic interface subjected to an antiplane force and a screw dislocation by means of the complex variable method. Explicit expressions are derived for the time-dependent stress field induced by the antiplane force and screw dislocation. Also presented is the time-dependent image force acting on the screw dislocation due to its interaction with the Kelvin-type viscoelastic interface. Second we investigate a rectangular inclusion with uniform antiplane eigenstrains embedded in one of the two bonded anisotropic half-planes by virtue of the derived Green's function for a line force. The explicit expressions for the time-dependent stress field induced by the rectangular inclusion are obtained in terms of the simple logarithmic and exponential integral functions. It is observed that in general the stresses exhibit the logarithmic singularity at the four corners of the rectangular inclusion. Our results also show that when one side of the rectangular inclusion lies on the viscoelastic interface, the interfacial tractions are still regular at the two corners of the inclusion which are located on the interface. Last we address a finite Griffith crack normal to the viscoelastic interface by means of the obtained Green's function for a screw dislocation. The crack problem is formulated in terms of a resulting singular integral equation which is solved numerically. The time-dependent stress intensity factors at the two crack tips are obtained and some interesting features are discussed. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Wang, X.; Pan, E.] Univ Akron, Dept Civil Engn, Akron, OH 44325 USA. [Wang, X.; Pan, E.] Univ Akron, Dept Appl Math, Akron, OH 44325 USA. [Chung, P. W.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Pan, E (reprint author), Univ Akron, Dept Civil Engn, Akron, OH 44325 USA. EM pan2@uakron.edu RI Pan, Ernian/F-4504-2011 OI Pan, Ernian/0000-0001-6640-7805 NR 13 TC 3 Z9 5 U1 2 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0020-7683 J9 INT J SOLIDS STRUCT JI Int. J. Solids Struct. PD OCT 1 PY 2009 VL 46 IS 20 BP 3725 EP 3733 DI 10.1016/j.ijsolstr.2009.06.021 PG 9 WC Mechanics SC Mechanics GA 498GR UT WOS:000270125800020 ER PT J AU Bultemeier, BW Netherland, MD Ferrell, JA Haller, WT AF Bultemeier, Brett W. Netherland, Mike D. Ferrell, Jason A. Haller, William T. TI Differential Herbicide Response among Three Phenotypes of Cabomba caroliniana SO INVASIVE PLANT SCIENCE AND MANAGEMENT LA English DT Article DE Fanwort; invasive; photosynthesis; aquatic AB Cabomba is a submersed aquatic plant native to the southeastern United States that is commonly sold worldwide through the aquarium trade. While infrequently managed in its native range, cabomba has recently been reported as invasive and tolerant to management efforts in the northern areas of the United States and in other countries. Invasive populations of cabomba are characterized by a phenotype that is bright green. In contrast, cabomba native to the southeastern United States is characterized by a red phenotype, while plants sold through the aquarium trade have intermediate characteristics of both the green and red phenotypes. The response of the three cabomba phenotypes to selected herbicides was evaluated by measuring photosynthetic response over the course of a static 144-hr exposure. Plants were exposed to the maximum recommended use-rates of 2,4-D, carfentrazone, copper, diquat, endothall (amine and dipotasium salt formulation), flumioxazin, quinclorac, triclopyr, and a combination of diquat and copper. A submersed plant species known to be sensitive to each of these herbicides was also included to compare photosynthetic response of the cabomba to a susceptible plant. The photosynthetic response of the red and green phenotypes differed following exposure to carfentrazone, diquat, 2,4-D, triclopyr, and flumioxazin. Diquat, diquat plus copper, endothall (amine salt), and flumioxazin were the only products that resulted in a greater than 50% reduction of photosynthesis in all three phenotypes of cabomba. A second experiment was conducted where all three phenotypes of cabomba were exposed to these four herbicides for 24 hr, and photosynthesis was evaluated. Following the 24-hr exposure, results further documented distinct response differences between the green and red phenotypes, with the green phenotype demonstrating a reduced sensitivity to the herbicides evaluated. Results demonstrate clear phenotypic differences in response to herbicide treatments and lack of susceptibility of cabomba to most herbicides. C1 [Bultemeier, Brett W.; Haller, William T.] Univ Florida, Dept Agron, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA. [Netherland, Mike D.] Univ Florida, Dept Agron, US Army Engineer Res & Dev Ctr, Gainesville, FL 32653 USA. [Ferrell, Jason A.] Univ Florida, Dept Agron, Gainesville, FL 32611 USA. RP Bultemeier, BW (reprint author), Univ Florida, Dept Agron, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA. EM bwbult@ufl.edu FU Florida Fish and Wildlife Conservation Commission Invasive Plant Management Section; Aquatic Ecosystem Restoration Foundation FX These studies were funded in part by the Florida Fish and Wildlife Conservation Commission Invasive Plant Management Section and the Aquatic Ecosystem Restoration Foundation. Permission to publish this information was granted by the chief of engineers. The authors would like to thank Dr. Christopher Mudge for assistance during this project. NR 30 TC 9 Z9 9 U1 4 U2 45 PU WEED SCI SOC AMER PI LAWRENCE PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 USA SN 1939-7291 J9 INVAS PLANT SCI MANA JI Invasive Plant Sci. Manag. PD OCT-DEC PY 2009 VL 2 IS 4 BP 352 EP 359 DI 10.1614/IPSM-09-035.1 PG 8 WC Plant Sciences SC Plant Sciences GA V17PE UT WOS:000207948300009 ER PT J AU Wang, Z Yang, H Zhang, F Pan, Z Capo-Aponte, J Reinach, PS AF Wang, Zheng Yang, Hua Zhang, Fan Pan, Zan Capo-Aponte, Jose Reinach, Peter S. TI Dependence of EGF-Induced Increases in Corneal Epithelial Proliferation and Migration on GSK-3 Inactivation SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Article ID GLYCOGEN-SYNTHASE KINASE-3; MAP KINASE; CHANNEL ACTIVATION; PROTEIN-KINASES; CELL-MIGRATION; PHOSPHORYLATION; PAXILLIN; GROWTH; CANCER; P38 AB PURPOSE. This study was designed to determine in human corneal epithelial cells (HCEC) whether the balance between epidermal growth factor (EGF)-induced increases in proliferation and migration is dependent on the duration and magnitude of extracellular signal-regulated kinase (Erk)1/2 activation. METHODS. Western blot analysis evaluated the phosphorylation status of Erk1/2 and phosphoinositide 3-kinase (PI3-K) along with cell cycle kinases, paxillin, and mitogen kinase protein phosphatase (MKP)-1. Proliferation and migration rates were determined by [(3)H]-thymidine incorporation and scratch wound healing assay, respectively. RESULTS. EGF induced increases in paxillin Ser-126 phosphorylation and cyclin D1 expression through transient Erk1/2 phosphorylation. However, preinhibition of glycogen synthase kinase (GSK)-3 activation with 20 mu M SB415286 prolonged and augmented this Erk1/2 response to EGF but decreased cyclin D1 expression, whereas p27Kip1 levels rose. In turn, the mitogenic response fell, whereas paxillin phosphorylation occurred 45 minutes sooner than without SB415286. In contrast, blocking PI3-K activation with LY294002 (50 mu M) eliminated EGF-induced GSK-3 inhibition and Erk1/2 phosphorylation as well as increases in proliferation and migration. SB415286 or U0126 (10 mu M) suppression of Erk1/2 phosphorylation blocked EGF-induced MKP-1 phosphorylation. Inhibition of EGF-induced increases in proliferation and migration by LY294002 was associated with sustained MKP-1 phosphorylation induced by GSK-3. Prolonging MKP-1 phosphorylation by LY294002 increased p27Kip1, whereas cyclin D1 levels fell. CONCLUSIONS. GSK-3-induced MKP-1 phosphorylation mediates negative feedback control between EGF receptor-linked PI3-K and ERK signaling pathways. Inhibition of such control prolongs Erk1/2 activation and alters the balance between EGF-induced increases in proliferation and migration. Therefore, these responses to EGF can be modulated through altering the feedback between these two pathways. (Invest Ophthalmol Vis Sci. 2009;50:4828-4835) DOI: 10.1167/iovs.08-2983 C1 [Wang, Zheng; Yang, Hua; Zhang, Fan; Pan, Zan; Reinach, Peter S.] SUNY, State Coll Optometry, Dept Biol Sci, New York, NY 10036 USA. [Capo-Aponte, Jose] USA, Aeromed Res Lab, Ft Rucker, AL USA. RP Reinach, PS (reprint author), SUNY, State Coll Optometry, Dept Biol Sci, New York, NY 10036 USA. EM preinach@sunyopt.edu RI Pan, Zan/E-5106-2011 FU National Institutes of Health [EY04795] FX Supported by National Institutes of Health Grant EY04795. NR 33 TC 12 Z9 12 U1 0 U2 2 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD OCT PY 2009 VL 50 IS 10 BP 4828 EP 4835 DI 10.1167/iovs.08-2983 PG 8 WC Ophthalmology SC Ophthalmology GA 497XE UT WOS:000270097200041 PM 19443725 ER PT J AU Deng, WW Waits, CM Morgan, B Gomez, A AF Deng, Weiwei Waits, C. Mike Morgan, Brian Gomez, Alessandro TI Compact multiplexing of monodisperse electrosprays SO JOURNAL OF AEROSOL SCIENCE LA English DT Article DE Electrospray; Microfabrication; Multiplex; Scaling law ID CONE-JET MODE; MASS-SPECTROMETRY; ION EVAPORATION; ELECTRIC-FIELD; TAYLOR CONES; SCALE-UP; MU-M; LIQUIDS; GENERATION; DROPLETS AB Widespread application of the cone-jet electrospray has been hampered by the low flow rate at which the spray is dispersed, despite the unique ability of this device to disperse quasi-monodispersed particles over a phenomenal size range. Compact multiplexing, that is, with a high number of sources per unit area, is indispensable for dramatically increasing the throughput and reducing the cost per electrospray source. We demonstrate the successful operation of multiplexed electrospray systems with an unprecedented packing density of up to 11,547 sources/cm(2). The devices were fabricated and operated by implementing three criteria: (a) the extractor electrode configuration should be used to localize the electric field: (b) the viscous pressure drop acting on the liquid should dominate with respect to the electrostatic pulling force by the electric field; and (c) the electric field "driving" the droplets between the extractor electrode and the collector should be sufficiently intense to avoid reversal of the droplet motion near the extractor (satellite trapping). All devices showed excellent droplet size uniformity across the entire spray region, which indicates effective decoupling of the electrospray sources even for closely packed nozzles. The experimental results show that these design criteria provide effective and reliable guidelines for the successful design and operation of multiplexed devices from first principles, that is, based only on knowledge of the suitability of a liquid for electrospray dispersion and of the critical liquid properties such as surface tension, viscosity and electric conductivity. As a result, the design of these devices for a given application is achievable without costly trial-and-error microfabrication trials. This development opens the door for applications requiring flows from multiplexing 10(6)-10(7) individual electrospray sources from industry-standard 12-in silicon wafers. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Deng, Weiwei; Gomez, Alessandro] Yale Univ, Dept Mech Engn, New Haven, CT 06520 USA. [Waits, C. Mike; Morgan, Brian] Army Res Lab, Adelphi, MD 20783 USA. RP Gomez, A (reprint author), Yale Univ, Dept Mech Engn, 9 Hillhouse Ave, New Haven, CT 06520 USA. EM Alessandro.Gomez@yale.edu RI Deng, Weiwei/C-2957-2011 FU US Army [W911NF-05-2-0015] FX The support of the US Army under Cooperative Agreement no. W911NF-05-2-0015 (Dr. C. Mike Waits, Contract Monitor) is gratefully acknowledged. NR 36 TC 49 Z9 49 U1 2 U2 18 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0021-8502 J9 J AEROSOL SCI JI J. Aerosol. Sci. PD OCT PY 2009 VL 40 IS 10 BP 907 EP 918 DI 10.1016/j.jaerosci.2009.07.002 PG 12 WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA 504PT UT WOS:000270630000007 ER PT J AU Kane, MC Londono, JD Beyer, FL Brennan, AB AF Kane, Marie C. Londono, J. David Beyer, Frederick L. Brennan, Anthony B. TI Characterization of the hierarchical structures of a dry nanopowder in a polymer matrix by X-ray scattering techniques SO JOURNAL OF APPLIED CRYSTALLOGRAPHY LA English DT Article ID NANOCOMPOSITES; DISPERSION; TIO2 AB There are many material properties benefits that can be realized by adding nano-sized filler particles to a polymeric resin, such as improvements in strength, modulus and optical transparency. However, the relative amount of improvement is highly dependent on the degree of particle dispersion or homogeneity within the nanocomposite. In this study, a commercially available dry titania nanopowder with a mean primary particle diameter of approximately 30 nm was mixed into an epoxy resin/hardener system to produce nanocomposite samples. Processing techniques such as ultrasonication and particle surface modification were used to produce nanocomposites with varying degrees of particle mixture homogeneity. The extent of nanoparticle dispersion was characterized by a combination of small-angle X-ray scattering and ultra-small-angle X-ray scattering. The measurement length scale ranged between 1 nm and several micrometres. Both measurement techniques provided information on the size distribution of primary particles, aggregates or particle agglomerates in the polymer nanocomposites, depending on the length scale (q region) of interest. Using this combination of processing and characterization techniques, a decrease in average particle cluster size of two orders of magnitude was observed between samples of varying particle mixture homogeneity. C1 [Kane, Marie C.] Savannah River Natl Lab, Aiken, SC USA. [Kane, Marie C.; Brennan, Anthony B.] Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. [Londono, J. David] DuPont Expt Stn, Wilmington, DE USA. [Beyer, Frederick L.] USA, Res Lab, Aberdeen, MD USA. RP Kane, MC (reprint author), Savannah River Natl Lab, Aiken, SC USA. EM marie.kane@srnl.doe.gov RI Brennan, Anthony/C-8552-2009 OI Brennan, Anthony/0000-0002-0431-8425 FU Particle Engineering Research Center at the University of Florida; Air Force Research Laboratory FX The authors thank the Particle Engineering Research Center at the University of Florida and the Air Force Research Laboratory for financial support of this work. NR 20 TC 2 Z9 2 U1 0 U2 3 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0021-8898 J9 J APPL CRYSTALLOGR JI J. Appl. Crystallogr. PD OCT PY 2009 VL 42 BP 925 EP 931 DI 10.1107/S0021889809029422 PG 7 WC Chemistry, Multidisciplinary; Crystallography SC Chemistry; Crystallography GA 495HV UT WOS:000269882600020 ER PT J AU Boysen, KA Hoover, JJ AF Boysen, K. A. Hoover, J. J. TI Swimming performance of juvenile white sturgeon (Acipenser transmontanus): training and the probability of entrainment due to dredging SO JOURNAL OF APPLIED ICHTHYOLOGY LA English DT Article ID SHOVELNOSE STURGEON; PALLID STURGEON; LAKE STURGEON; RIVER; FULVESCENS; SPEED AB P>White sturgeon, Acipenser transmontanus (Richardson), are at risk of entrainment from dredging, with young-of-the-year fish at greatest risk. To evaluate this entrainment risk, swimming performance trials were conducted in a laboratory swim tunnel with hatchery-reared juvenile white sturgeon with varying experience levels including: naive (only tested once), tested (re-tested after being kept in no flow) and trained (re-tested after kept in flow for nearly three weeks). Individuals of various sizes (80-100 mm TL) and all experience levels were strongly rheotactic (> 80%), but endurance was highly variable among fish. Small juveniles [< 82 mm total length (TL)] had lower escape speeds (< 40 cm s(-1)) than medium (82-92 mm TL) and large (> 93 mm TL) naive fish (42-45 cm s(-1)), all of which had lower escape speeds than trained fish (72 cm s(-1)). Behavior was also highly variable among fish. Overall, benthic station-holding behaviors were least frequent in small fish, intermediate in medium and large fish, and most frequent in trained large fish. Probability of entrainment of juvenile white sturgeon can be reduced by maintaining dredge head flow fields at less than 45 cm s(-1) for wild-spawned fish or by rearing hatchery fish to > 93 mm TL and exposing the fish to moderate flow velocities (10-12 cm s(-1)) prior to their release. C1 [Boysen, K. A.; Hoover, J. J.] USA, Waterways Expt Stn, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Boysen, KA (reprint author), USA, Waterways Expt Stn, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Krista.A.Boysen@usace.army.mil FU Dredging Operations and Environmental Research Program through the U.S. Army Engineer Research and Development Center (ERDC) in Vicksburg, MS FX Study was done in partial fulfillment of the requirements for the Master of Science degree in Biology at Mississippi College by the senior author. Faculty advisors were Robert Hamilton and Bill Stark. Peter Struffenegger and Anita Bunter from Stolt Sea Farm, Sacramento, CA provided the sturgeon used in this study. This study was funded by the Dredging Operations and Environmental Research Program through the U.S. Army Engineer Research and Development Center (ERDC) in Vicksburg, MS. Catherine Murphy provided statistical analyses and reviewed the manuscript. Jack Killgore also reviewed the manuscript. Permission to publish was provided by the Chief of Engineers. We thank the staff of the Fish Team at the ERDC for aid throughout the study. NR 20 TC 12 Z9 12 U1 0 U2 18 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0175-8659 J9 J APPL ICHTHYOL JI J. Appl. Ichthyol. PD OCT PY 2009 VL 25 BP 54 EP 59 DI 10.1111/j.1439-0426.2009.01247.x PG 6 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA 490JD UT WOS:000269496100010 ER PT J AU Divers, SJ Boone, SS Hoover, JJ Boysen, KA Killgore, KJ Murphy, CE George, SG Camus, AC AF Divers, S. J. Boone, S. S. Hoover, J. J. Boysen, K. A. Killgore, K. J. Murphy, C. E. George, S. G. Camus, A. C. TI Field endoscopy for identifying gender, reproductive stage and gonadal anomalies in free-ranging sturgeon (Scaphirhynchus) from the lower Mississippi River SO JOURNAL OF APPLIED ICHTHYOLOGY LA English DT Article ID SHOVELNOSE STURGEON; PALLID STURGEON; WHITE STURGEON; MISSOURI; SEX; CONTAMINANTS; ABUNDANCE; GROWTH AB P>Thirty-six sturgeon (Scaphirhynchus spp.) were captured from the lower Mississippi River using baited trot-lines, anesthetized using tricaine methanesulfonate, and subjected to endoscopic evaluation of their coelom (coelioscopy) on the river bank. Using a 2.7 mm rod-lens telescope and gravity-fed sterile saline infusion, gender and reproductive stage were determined in the field, and later re-evaluted and confirmed by histology of endoscopic biopsies in the laboratory. Gender and reproductive stage were determined endoscopically in all fish without complication, and proved to correlate 100% with biopsy histology. Modern rod-lens telescopes and sterile saline insufflation can be used under field conditions, provide superior visualization of sturgeon gonads, and offer a high degree of accuracy even with inactive gonads. Rigid endoscopy is recommended as a minimally-invasive means of assessing the reproductive organs of sturgeon and other fish. C1 [Divers, S. J.; Boone, S. S.] Univ Georgia, Coll Vet Med, Dept Small Anim Med & Surg Zool Med, Athens, GA 30602 USA. [Hoover, J. J.; Killgore, K. J.] USA, Waterways Expt Stn, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Boysen, K. A.; Murphy, C. E.] Jaya Corp, Vicksburg, MS USA. [George, S. G.] Bowhead Informat Technol Serv, Vicksburg, MS USA. [Camus, A. C.] Univ Georgia, Coll Vet Med, Dept Pathol, Athens, GA 30602 USA. RP Divers, SJ (reprint author), Univ Georgia, Coll Vet Med, Dept Small Anim Med & Surg Zool Med, 501 DW Brooks Dr, Athens, GA 30602 USA. EM shdivers@uga.edu FU US Army Corporations of Engineers Mississippi Valley Division FX Funding was provided by the US Army Corporations of Engineers Mississippi Valley Division. The sturgeon sampling workshop was organized by Paul Hartfield, USFWS. Assistance collecting fish was provided by Jay Collins, Neil Douglas, Phil Kirk, William Lancaster, and Bradley Lewis. Endoscopy equipment was provided by Karl Storz Endoscopy America, with endoscopy technical support provided by Mike Bateman. Assistance with endoscopic procedures was provided by Jan Dean, Trey Dunn, and Matt Wegener. Permission to publish was granted by the US Army Chief of Engineers. NR 30 TC 29 Z9 29 U1 0 U2 4 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0175-8659 J9 J APPL ICHTHYOL JI J. Appl. Ichthyol. PD OCT PY 2009 VL 25 BP 68 EP 74 DI 10.1111/j.1439-0426.2009.01337.x PG 7 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA 490JD UT WOS:000269496100012 ER PT J AU Gao, YH Chen, MK Yang, CE Chang, YC Yin, S Hui, RQ Ruffin, P Brantley, C Edwards, E Luo, C AF Gao, Yaohui Chen, Meng-Ku Yang, Chia-En Chang, Yun-Ching Yin, Stuart Hui, Rongqing Ruffin, Paul Brantley, Christina Edwards, Eugene Luo, Claire TI Analysis of terahertz generation via nanostructure enhanced plasmonic excitations SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID FEMTOSECOND OPTICAL PULSES; RADIATION; SPECTROSCOPY; SURFACES; ANTENNAS AB In this paper, we conduct a quantitative study on the physical mechanism of electrons dynamics near the nanostructured metal film surfaces, as well as the efficiency of generated terahertz radiation associated with different types of nanostructures. The simulation results show that although the oscillating motion of emitted electrons outside the metal surface may affect the terahertz generation efficiency to some extent, this efficiency is predominantly determined by the electric field magnitude inside the metal film associated with nanostructure enhanced plasmonic excitations. Due to the field enhancement effect of the nanostructure, an appropriately designed nanostructured surface could greatly enhance the strength of generated terahertz signal via the increased nonlinear interactions between the light and the nanostructures. (C) 2009 American Institute of Physics. [doi: 10.1063/1.3236629] C1 [Gao, Yaohui; Chen, Meng-Ku; Yang, Chia-En; Chang, Yun-Ching; Yin, Stuart] Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. [Hui, Rongqing] Univ Kansas, Dept Elect Engn & Comp Sci, Lawrence, KS 66045 USA. [Ruffin, Paul; Brantley, Christina; Edwards, Eugene] USA, Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA. RP Yin, S (reprint author), Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. EM sxy105@psu.edu FU ONR FX The authors greatly acknowledge the partial financial support of this work by ONR basic research program. NR 17 TC 17 Z9 17 U1 0 U2 4 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD OCT 1 PY 2009 VL 106 IS 7 AR 074302 DI 10.1063/1.3236629 PG 7 WC Physics, Applied SC Physics GA 508FT UT WOS:000270915600101 ER PT J AU Pan, E Zou, Y Chung, PW Albrecht, JD AF Pan, Ernie Zou, Yu Chung, Peter W. Albrecht, John D. TI Strain-induced variations of electronic energy band edges of embedded semiconductor quantum dots in half-space substrates SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID 1.5 MU-M; PIEZOELECTRIC FIELDS; OPTICAL-PROPERTIES; INAS/GAAS; EMISSION; INAS AB The strain-induced local electronic band edge states in semiconductor quantum dots (QDs) are studied using a k.p description of the electronic eigenstates coupled with the induced lattice strain as calculated using the continuum mechanics (CM) description. In the CM method, the misfit-lattice induced strain can be reduced to an analytical expression that is straightforward to evaluate numerically. Different from most previous analyses for QDs in infinite spaces, we address cubic and pyramidal QDs located in half-space substrates with different lattice orientations, which more realistically describe experimental situations in most instances. The band edges within the cubic and pyramidal InAs QDs embedded in GaAs substrates are predicted within the six-band k.p basis via both a published approximation and the presented exact approach. Comparison of the strain-induced local band edge shows that the approximate method adopted previously in literature could result in a substantial error near the interface region of the QD. The strain-induced band edges along the bottom center line of the QD can differ by a factor of 2 between the two approaches. Furthermore, the effect of the free surface on the strain-induced band edges is studied by varying the depth of the buried QD. When the QD is moved away from the surface, the band edges converge in a consistent way to the infinite-space solution. Comparison with available experimental results validates our exact model within the half-space substrate and shows the importance of treating the surface in a theoretically rigorous way. (C) 2009 American Institute of Physics. [doi:10.1063/1.3234383] C1 [Pan, Ernie; Zou, Yu] Univ Akron, Comp Modeling & Simulat Grp, Coll Engn, Akron, OH 44325 USA. [Chung, Peter W.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Albrecht, John D.] USAF, Res Lab, Wright Patterson AFB, OH 45433 USA. RP Pan, E (reprint author), Univ Akron, Comp Modeling & Simulat Grp, Coll Engn, Akron, OH 44325 USA. EM pan2@uakron.edu RI Pan, Ernian/F-4504-2011 OI Pan, Ernian/0000-0001-6640-7805 NR 47 TC 0 Z9 0 U1 1 U2 5 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD OCT 1 PY 2009 VL 106 IS 7 AR 073504 DI 10.1063/1.3234383 PG 12 WC Physics, Applied SC Physics GA 508FT UT WOS:000270915600026 ER PT J AU Krishnan, K Crouse, LCB Bazar, MA Major, MA Reddy, G AF Krishnan, Kannan Crouse, Lee C. B. Bazar, Matthew A. Major, Michael A. Reddy, Gunda TI Physiologically based pharmacokinetic modeling of cyclotrimethylenetrinitramine in male rats SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE RDX; PBPK model; pharmacokinetics ID HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE RDX; PARTITION-COEFFICIENTS; ORGANIC-CHEMICALS; RISK-ASSESSMENT; PREDICTION; HUMANS; PLASMA; BLOOD; SOILS AB A physiologically based pharmacokinetic (PBPK) model for simulating the kinetics of cyclotrimethylene trinitramine (RDX) in male rats was developed. The model consisted of five compartments interconnected by systemic circulation. The tissue uptake of RDX was described as a perfusion-limited process whereas hepatic clearance and gastrointestinal absorption were described as first-order processes. The physiological parameters for the rat were obtained from the literature whereas the tissue: blood partition coefficients were estimated on the basis of the tissue and blood composition as well as the lipophilicity characteristics of RDX (logP = 0.87). The tissue: blood partition coefficients (brain, 1.4; muscle, 1; fat, 7.55; liver, 1.2) obtained with this algorithmic approach were used without any adjustment, since a focused in vitro study indicated that the relative concentration of RDX in whole blood and plasma is about 1:1. An initial estimate of metabolic clearance of RDX (2.2 h(-1) kg(-1)) was obtained by fitting PBPK model simulations to the data on plasma kinetics in rats administered 5.5 mg kg(-1) i.v. The rat PBPK model without any further change in parameter values adequately simulated the blood kinetic data for RDX at much lower doses (0.77 and 1.04 mg kg(-1) i.v.), collected in this study. The same model, with the incorporation of a first order oral absorption rate constant (K(a) 0.75 h(-1)), reproduced the blood kinetics of RDX in rats receiving a single gavage dose of 1.53 or 2.02 mg kg(-1). Additionally, the model simulated the plasma and blood kinetics of orally administered RDX at a higher dose (100 mg kg(-1)) or lower doses (0.2 or 1.24 mg kg(-1)) in male rats. Overall, the rat PBPK model for RDX with its parameters adequately simulates the blood and plasma kinetic data, obtained following i.v. doses ranging from 0.77 to 5.5 mg kg(-1) as well as oral doses ranging from 0.2 to 100 mg kg(-1). Published in 2009 by John Wiley & Sons, Ltd. C1 [Crouse, Lee C. B.; Bazar, Matthew A.; Major, Michael A.; Reddy, Gunda] USA, Ctr Hlth Promot & Prevent Med, Directorate Toxicol, Aberdeen Proving Ground, MD 21010 USA. [Krishnan, Kannan] Univ Montreal, DSEST, Montreal, PQ, Canada. RP Reddy, G (reprint author), USA, Ctr Hlth Promot & Prevent Med, Directorate Toxicol, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM gunda.reddy@us.army.mil NR 25 TC 7 Z9 8 U1 1 U2 2 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 0260-437X J9 J APPL TOXICOL JI J. Appl. Toxicol. PD OCT PY 2009 VL 29 IS 7 BP 629 EP 637 DI 10.1002/jat.1455 PG 9 WC Toxicology SC Toxicology GA 514PL UT WOS:000271407100011 PM 19629953 ER PT J AU Wright, CW Walsh, EJ Krabill, WB Shaffer, WA Baig, SR Peng, M Pietrafesa, LJ Garcia, AW Marks, FD Black, PG Sonntag, J Beckley, BD AF Wright, C. W. Walsh, E. J. Krabill, W. B. Shaffer, W. A. Baig, S. R. Peng, M. Pietrafesa, L. J. Garcia, A. W. Marks, F. D., Jr. Black, P. G. Sonntag, J. Beckley, B. D. TI Measuring Storm Surge with an Airborne Wide-Swath Radar Altimeter SO JOURNAL OF ATMOSPHERIC AND OCEANIC TECHNOLOGY LA English DT Article ID SPECTRUM SPATIAL VARIATION; DIRECTIONAL WAVE SPECTRA; SEA-SURFACE; WIND; HURRICANES; MODEL; VERIFICATION; INUNDATION; SYSTEM AB Over the years, hurricane track forecasts and storm surge models, as well the digital terrain and bathymetry data they depend on, have improved significantly. Strides have also been made in the knowledge of the detailed variation of the surface wind field driving the surge. The area of least improvement has been in obtaining data on the temporal/spatial evolution of the mound of water that the hurricane wind and waves push against the shore to evaluate the performance of the numerical models. Tide gauges in the vicinity of the landfall are frequently destroyed by the surge. Survey crews dispatched after the event provide no temporal information and only indirect indications of the maximum water level over land. The landfall of Hurricane Bonnie on 26 August 1998, with a surge less than 2 m. provided an excellent opportunity to demonstrate the potential benefits of direct airborne measurement of the temporal/spatial evolution of the water level over a large area. Despite a 160-m variation in aircraft altitude. an 11.5-m variation in the elevation of the mean sea surface relative to the ellipsoid over the flight track, and the tidal variation over the 5-h data acquisition interval. a survey-quality global positioning system (GPS) aircraft trajectory allowed the NASA scanning radar altimeter carried by a NOAA hurricane research aircraft to demonstrate that an airborne wide-swath radar altimeter could produce targeted measurements of storm surge that would provide an absolute standard for assessing the accuracy of numerical storm surge models. C1 [Wright, C. W.; Walsh, E. J.; Krabill, W. B.] NASA, Goddard Space Flight Ctr, Wallops Isl, VA 23337 USA. [Shaffer, W. A.] NOAA, Natl Weather Serv, Silver Spring, MD 20910 USA. [Baig, S. R.] NOAA, Trop Predict Ctr, Miami, FL USA. [Peng, M.; Pietrafesa, L. J.] N Carolina State Univ, Coll Phys & Math Sci, Raleigh, NC 27695 USA. [Garcia, A. W.] USA, Coastal & Hydraul Lab, Engn R&D Ctr, Vicksburg, MS USA. [Marks, F. D., Jr.; Black, P. G.] NOAA, Atlantic Oceanog & Meteorol Lab, Hurricane Res Div, Miami, FL 33149 USA. [Sonntag, J.] EG&G Tech Serv Inc, Wallops Isl, VA USA. [Beckley, B. D.] SGT Inc, Greenbelt, MD USA. RP Walsh, EJ (reprint author), NOAA, Earth Syst Res Lab, R PSD3,325 Broadway, Boulder, CO 80305 USA. EM edward.walsh@noaa.gov RI Marks, Frank/A-5733-2011 OI Marks, Frank/0000-0003-0371-5514 FU Joint Hurricane Testbed of the NOAA/U.S; Weather Research Program (USWRP) at the Tropical Prediction Center/National Hurricane Center; NASA SRA; NOAA Aircraft Operations Center FX These measurements and this analysis were supported by the NASA Physical Oceanography Program. The analysis was also supported by the Joint Hurricane Testbed of the NOAA/U.S. Weather Research Program (USWRP) at the Tropical Prediction Center/National Hurricane Center. Donald E. Hines maintained the NASA SRA, and the NOAA Aircraft Operations Center is thanked for their expertise in helping install the system and executing the complex flight patterns. E. J. Walsh thanks Hendilk Tolman of NCEP for useful discussion. NR 25 TC 1 Z9 1 U1 1 U2 7 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0739-0572 J9 J ATMOS OCEAN TECH JI J. Atmos. Ocean. Technol. PD OCT PY 2009 VL 26 IS 10 BP 2200 EP 2215 DI 10.1175/2009JTECHO627.1 PG 16 WC Engineering, Ocean; Meteorology & Atmospheric Sciences SC Engineering; Meteorology & Atmospheric Sciences GA 506ZE UT WOS:000270817600016 ER PT J AU Andzelm, J Rinderspacher, BC Rawlett, A Dougherty, J Baer, R Govind, N AF Andzelm, Jan Rinderspacher, Berend C. Rawlett, Adam Dougherty, Joseph Baer, Roi Govind, Niranjan TI Performance of DFT Methods in the Calculation of Optical Spectra of TCF-Chromophores SO JOURNAL OF CHEMICAL THEORY AND COMPUTATION LA English DT Article ID DENSITY-FUNCTIONAL THEORY; GENERALIZED-GRADIENT-APPROXIMATION; CONTINUUM SOLVATION MODELS; TRANSFER EXCITED-STATES; LARGE MOLECULES; CONFIGURATION-INTERACTION; ELECTROOPTIC ACTIVITY; EXCITATION-ENERGIES; ABSORPTION-SPECTRA; GUEST-HOST AB We present electronic structure calculations of the ultraviolet/visible (UV-vis) spectra of highly active push-pull chromophores containing the tricyanofuran (TCF) acceptor group. In particular, we have applied the recently developed long-range corrected Baer-Neuhauser-Livshits (BNL) exchange-correlation functional. The performance of this functional compares favorably with other density functional theory (DFT) approaches, including the CAM-B3LYP functional. The accuracy of UV-vis results for these molecules is best at low values of attenuation parameters (gamma) for both BNL and CAM-B3LYP functionals. The optimal value of gamma is different for the charge-transfer (CT) and pi-pi* excitations. The BNL and PBE0 exchange correlation functionals capture the CT states particularly well, while the pi-pi* excitations are less accurate and system dependent. Chromophore conformations, which considerably affect the molecular hyperpolarizability, do not significantly influence the UV-vis spectra on average. As expected, the color of chromophores is a sensitive function of modifications to its conjugated framework and is not significantly affected by increasing aliphatic chain length linking a chromophore to a polymer. For selected push-pull aryl-chromophores, we find a significant dependence of absorption spectra on the strength of diphenylaminophenyl donors. C1 [Andzelm, Jan; Rinderspacher, Berend C.; Rawlett, Adam; Dougherty, Joseph] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Baer, Roi] Hebrew Univ Jerusalem, Inst Chem, IL-91904 Jerusalem, Israel. [Baer, Roi] Hebrew Univ Jerusalem, Fritz Haber Ctr Mol Dynam, IL-91904 Jerusalem, Israel. [Govind, Niranjan] Pacific NW Natl Lab, William R Wiley Environm Mol Sci Lab, Richland, WA 99352 USA. RP Andzelm, J (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM jandzelm@arl.army.mil RI Govind, Niranjan/D-1368-2011 NR 62 TC 39 Z9 39 U1 0 U2 20 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1549-9618 EI 1549-9626 J9 J CHEM THEORY COMPUT JI J. Chem. Theory Comput. PD OCT PY 2009 VL 5 IS 10 BP 2835 EP 2846 DI 10.1021/ct900231r PG 12 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 504DX UT WOS:000270595800024 PM 26631795 ER PT J AU Hickey, PW Sutton, DA Fothergill, AW Rinaldi, MG Wickes, BL Schmidt, HJ Walsh, TJ AF Hickey, Patrick W. Sutton, Deanna A. Fothergill, Annette W. Rinaldi, Michael G. Wickes, Brian L. Schmidt, Howard J. Walsh, Thomas J. TI Trichosporon mycotoxinivorans, a Novel Respiratory Pathogen in Patients with Cystic Fibrosis SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID CHRONIC GRANULOMATOUS-DISEASE; OF-THE-LITERATURE; AMPHOTERICIN-B; PULLULANS INFECTION; GENUS TRICHOSPORON; EMERGING PATHOGEN; IDENTIFICATION; LOUBIERI; BEIGELII; THERAPY AB This report describes the molecular epidemiology, in vitro susceptibility, colonial and microscopic morphologies, and biochemical features of Trichosporon mycotoxinivorans, a newly recognized pathogen that appears to have a propensity for patients with cystic fibrosis. The index patient died with histologically documented Trichosporon pneumonia complicating cystic fibrosis. This is also the first report of disease caused by a Trichosporon species in a nontransplant patient with cystic fibrosis. As T. mycotoxinivorans has not previously been recognized as a respiratory pathogen, the significance of its recovery from sputum samples was not initially appreciated. Genetic analysis of archived clinical samples found three additional cases of T. mycotoxinivorans infection which had previously been identified as other members of the genus. An additional isolate of T. mycotoxinivorans was identified from a clinical sample on initial testing. Three of these four cases were also patients with cystic fibrosis. All isolates had MICs at 48 h of amphotericin B of >= 1 mu g/ml and of echinocandins of >= 16 mu g/ml, but they displayed various susceptibilities to the triazoles. In summary, Trichosporon mycotoxinivorans is a newly recognized human pathogen that is associated with cystic fibrosis. C1 [Hickey, Patrick W.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Hickey, Patrick W.] Walter Reed Army Med Ctr, Div Pediat Infect Dis, Washington, DC 20307 USA. [Schmidt, Howard J.] Walter Reed Army Med Ctr, Div Pediat Pulmonol, Washington, DC 20307 USA. [Sutton, Deanna A.; Fothergill, Annette W.; Rinaldi, Michael G.] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, Fungus Testing Lab, San Antonio, TX 78229 USA. [Wickes, Brian L.] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol, San Antonio, TX 78229 USA. [Schmidt, Howard J.] Virginia Commonwealth Univ, Div Pediat Pulmonol, Richmond, VA USA. [Walsh, Thomas J.] NCI, Pediat Oncol Branch, Immunocompromised Host Sect, Bethesda, MD 20892 USA. RP Hickey, PW (reprint author), Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM phickey@usuhs.mil FU U. S. Army Medical Research and Materiel Command, Office of Congressionally Directed Medical Research Programs [PR054228]; National Cancer Institute FX B. L. W. is supported by grant PR054228 from the U. S. Army Medical Research and Materiel Command, Office of Congressionally Directed Medical Research Programs. This work was supported in part by the intramural research program of the National Cancer Institute. NR 34 TC 30 Z9 30 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD OCT PY 2009 VL 47 IS 10 BP 3091 EP 3097 DI 10.1128/JCM.00460-09 PG 7 WC Microbiology SC Microbiology GA 501BC UT WOS:000270351700003 PM 19656976 ER PT J AU Mahlen, SD Clarridge, JE AF Mahlen, Steven D. Clarridge, Jill E., III TI Site and Clinical Significance of Alloscardovia omnicolens and Bifidobacterium Species Isolated in the Clinical Laboratory SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID HUMAN DENTAL-CARIES; GEN. NOV.; DENTICOLENS AB Most of the members of the genus Bifidobacterium, including the related organism Alloscardovia omnicolens, are inhabitants of the gastrointestinal tract and oral cavity of humans and animals and have been considered nonpathogenic for humans. However, the actual site of isolation and the clinical significance of A. omnicolens and of Bifidobacterium species are unclear. This may be due in part to the difficulties in distinguishing these organisms from other genera such as Actinomyces. To determine the potential disease-causing role of these organisms, we analyzed the clinical significance of 15 A. omnicolens and Bifidobacterium isolates identified by 16S rRNA gene sequencing from a clinical laboratory. All of the organisms in this study were isolated from sterile sites or in significant numbers by standard clinical microbiological culture methods. Our 15 clinical strains fit into only four species: A. omnicolens (five isolates), Bifidobacterium scardovii (four isolates), B. longum (two isolates), and B. breve (four isolates). All five A. omnicolens isolates, one of the B. breve isolates, and three of the four B. scardovii isolates were cultured from urine at 105 CFU/ml. One B. scardovii isolate was from a patient with a genitourinary tract wound infection, two B. longum isolates were from abdominal wounds, and three B. breve isolates were from blood cultures. This study enlarges the spectrum of diseases and clinical sources associated with A. omnicolens and Bifidobacterium species and addresses identification problems. C1 [Mahlen, Steven D.] Univ Washington, Dept Lab Med, USA, Seattle, WA 98195 USA. [Clarridge, Jill E., III] Vet Affairs Puget Sound Hlth Care Syst, Pathol & Lab Med Serv, Seattle, WA 98108 USA. RP Clarridge, JE (reprint author), VA PSHCS, Pathol & Lab Med Serv 113, 1660 S Columbian Way, Seattle, WA 98108 USA. EM jill.clarridge@va.gov NR 13 TC 17 Z9 17 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD OCT PY 2009 VL 47 IS 10 BP 3289 EP 3293 DI 10.1128/JCM.00555-09 PG 5 WC Microbiology SC Microbiology GA 501BC UT WOS:000270351700032 PM 19641056 ER PT J AU Calvano, TP Ferraro, DM Prakash, V Mende, K Hospenthal, DR AF Calvano, Tatjana P. Ferraro, David M. Prakash, Vidhya Mende, Katrin Hospenthal, Duane R. TI Community-Associated Methicillin-Resistant Staphylococcus aureus Mediastinitis SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID FIELD GEL-ELECTROPHORESIS; EPIDEMIOLOGY AB Community-associated methicillin (meticillin)-resistant Staphylococcus aureus (CA-MRSA) continues to emerge as a cause of serious infections, chiefly of the skin and soft tissues. We present the first documented case of CA-MRSA mediastinitis in an adult. Blood and mediastinal isolates were characterized as CA-MRSA by pulsed-field gel electrophoresis and susceptibility testing. C1 [Calvano, Tatjana P.; Ferraro, David M.; Prakash, Vidhya; Mende, Katrin; Hospenthal, Duane R.] San Antonio Mil Med Ctr, Dept Med, Ft Sam Houston, TX USA. [Mende, Katrin] Infect Dis Clin Res Program, Bethesda, MD USA. RP Hospenthal, DR (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM duane.hospenthal@amedd.army.mil RI Valle, Ruben/A-7512-2013 NR 12 TC 1 Z9 1 U1 2 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD OCT PY 2009 VL 47 IS 10 BP 3367 EP 3369 DI 10.1128/JCM.00872-09 PG 3 WC Microbiology SC Microbiology GA 501BC UT WOS:000270351700049 PM 19656974 ER PT J AU Tully, CC Romanelli, AM Sutton, DA Wickes, BL Hospenthal, DR AF Tully, Charla C. Romanelli, Anna M. Sutton, Deanna A. Wickes, Brian L. Hospenthal, Duane R. TI Fatal Actinomucor elegans var. kuwaitiensis Infection following Combat Trauma SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID CUTANEOUS MUCORMYCOSIS; ABSIDIA-CORYMBIFERA; ZYGOMYCOSIS; TAIWANENSIS; PATIENT; DNA AB We report the first case of invasive mucormycosis secondary to Actinomucor elegans infection. A severely injured soldier with a fatal A. elegans var. kuwaitiensis infection is described. The identification of this fungus was performed by classical and molecular methods, and this report documents the pathogenicity of the recently described variety Actinomucor elegans var. kuwaitiensis. C1 [Hospenthal, Duane R.] Brooke Army Med Ctr, Infect Dis MCHE MDI, Infect Dis Serv, Dept Med, Ft Sam Houston, TX 78234 USA. [Tully, Charla C.] Wilford Hall USAF Med Ctr, Dept Med, Lackland AFB, TX 78236 USA. [Romanelli, Anna M.; Wickes, Brian L.] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, San Antonio, TX 78229 USA. [Sutton, Deanna A.] Univ Texas Hlth Sci Ctr San Antonio, Fungus Testing Lab, Dept Pathol, San Antonio, TX 78229 USA. [Sutton, Deanna A.; Wickes, Brian L.; Hospenthal, Duane R.] San Antonio Ctr Med Mycol, San Antonio, TX USA. RP Hospenthal, DR (reprint author), Brooke Army Med Ctr, Infect Dis MCHE MDI, Infect Dis Serv, Dept Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM duane.hospenthal@amedd.army.mil FU NIDCR [DE14318]; U.S. Army Medical Research and Materiel Command [PR054228] FX A. M. R. was supported by NIDCR grant DE14318 ( CO STAR). B. L. W. was supported by grant PR054228 from the U.S. Army Medical Research and Materiel Command, Office of Congressionally Directed Medical Research Programs. The sponsor or funding organization had no role in the design or conduct of this research. NR 22 TC 9 Z9 10 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD OCT PY 2009 VL 47 IS 10 BP 3394 EP 3399 DI 10.1128/JCM.00797-09 PG 6 WC Microbiology SC Microbiology GA 501BC UT WOS:000270351700057 PM 19675213 ER PT J AU Nguyen, V Schultz, G Balachandran, B AF Nguyen, Vincent Schultz, Gregory Balachandran, Balakumar TI Lateral Load Transfer Effects on Bifurcation Behavior of Four-Wheel Vehicle System SO JOURNAL OF COMPUTATIONAL AND NONLINEAR DYNAMICS LA English DT Article CT ASME International Design Engineering Technical Conferences/Computers and Information in Engineering Conference CY SEP 04-07, 2007 CL Las Vegas, NV SP ASME, Design Engn Div, ASME, Comp & Informat Engn Div ID TYRE SHEAR FORCE; STABILITY; DYNAMICS; PARAMETERS; BRAKING; MODEL AB In this article, vehicle handling behavior of a nonlinear four-wheel vehicle system is studied. Bifurcations with respect to vehicle speed and roll moment distribution are examined for innate understeering and oversteering models. Lateral load transfer effects are investigated, and these effects are shown to alter the bifurcation locations for oversteering vehicles when the roll moment distribution is adjusted. When the roll moment distribution is used as a control parameter, transitions between bifurcation behavior characteristic of oversteering systems and bifurcation behavior characteristic of understeering systems are observed. This effort provides a framework for developing a complete vehicle handling assessment in terms of nonlinear regions of performance, transient behavior, and lateral load effects. [DOI: 10.1115/1.3192128] C1 [Nguyen, Vincent; Balachandran, Balakumar] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. [Schultz, Gregory] USA, Aberdeen Test Ctr, Aberdeen, MD 21005 USA. RP Nguyen, V (reprint author), Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. EM vince1@umd.edu; gregory.schultz@atc.army.mil; balab@umd.edu NR 25 TC 5 Z9 6 U1 1 U2 6 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 1555-1423 J9 J COMPUT NONLIN DYN JI J. Comput. Nonlinear Dyn. PD OCT PY 2009 VL 4 IS 4 AR 041007 DI 10.1115/1.3192128 PG 12 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 500EB UT WOS:000270279900007 ER PT J AU Adler, AB Bliese, PD McGurk, D Hoge, CW Castro, CA AF Adler, Amy B. Bliese, Paul D. McGurk, Dennis Hoge, Charles W. Castro, Carl Andrew TI Battlemind Debriefing and Battlemind Training as Early Interventions With Soldiers Returning From Iraq: Randomization by Platoon SO JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY LA English DT Article DE combat experiences; debriefing; soldiers; postdeployment; stigma ID POSTTRAUMATIC-STRESS-DISORDER; CONTROLLED-TRIAL; PSYCHOLOGICAL TRAUMA; FUTURE-DIRECTIONS; PRIMARY-CARE; GROUP-SIZE; VICTIMS; COMBAT; VETERANS; VIETNAM AB Researchers have found that there is an increase in mental heath problems as a result of military-related traumatic events, and such problems increase in the months following return from combat. Nevertheless, researchers have not assessed the impact of early intervention efforts with this at-risk population. In the present study, the authors compared different early interventions with 2,297 U.S. soldiers following a year-long deployment to Iraq. Platoons were randomly assigned to standard postdeployment stress education, Battlemind debriefing, and small and large group Battlemind training. Results from a 4-month follow-up with 1,060 participants showed those with high levels of combat exposure who received Battlemind debriefing reported fewer posttraumatic stress symptoms, depression symptoms, and sleep problems than those in stress education. Small group Battlemind training participants with high combat exposure reported fewer posttraumatic stress symptoms and sleep problems than stress education participants. Compared to stress education participants, large group Battlemind training participants with high combat exposure reported fewer posuraumatic stress symptoms and lower levels of stigma and, regardless of combat exposure, reported fewer depression symptoms. Findings demonstrate that brief early interventions have the potential to be effective with at-risk occupational groups. C1 [Adler, Amy B.; Bliese, Paul D.] USA, Med Res Unit Europe, APO, AE 09042 USA. [Adler, Amy B.; Bliese, Paul D.] Walter Reed Army Inst Res, Heidelberg, Germany. [Bliese, Paul D.; Hoge, Charles W.] Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Castro, Carl Andrew] Mil Operat Med Med Res & Mat Command, Ft Detrick, MD USA. RP Adler, AB (reprint author), USA, Med Res Unit, APO, AE 09042 USA. EM amy.adler@us.army.mil; paut.bliese@us.army.mil NR 56 TC 132 Z9 132 U1 5 U2 27 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0022-006X J9 J CONSULT CLIN PSYCH JI J. Consult. Clin. Psychol. PD OCT PY 2009 VL 77 IS 5 BP 928 EP 940 DI 10.1037/a0016877 PG 13 WC Psychology, Clinical SC Psychology GA 503TX UT WOS:000270564400012 PM 19803572 ER PT J AU Summers, TA Rush, W Aguilera, N Lupton, G AF Summers, Thomas A., Jr. Rush, Walter Aguilera, Nadine Lupton, George TI Cutaneous involvement in the lymphoepithelioid variant of peripheral T-cell lymphoma, unspecified (Lennert lymphoma). Report of a case and review of the literature SO JOURNAL OF CUTANEOUS PATHOLOGY LA English DT Article ID LENNERTS LYMPHOMA; CLINICOPATHOLOGIC ENTITY; EPITHELIOID HISTIOCYTES; MALIGNANT-LYMPHOMA; DISEASE AB Summers TA, Rush W, Aguilera N, Lupton G. Cutaneous involvement in the lymphoepithelioid variant of peripheral T-cell lymphoma, unspecified (Lennert lymphoma). Report of a case and review of the literature. C1 [Summers, Thomas A., Jr.] Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. [Rush, Walter; Lupton, George] Armed Forces Inst Pathol, Dept Dermatopathol, Washington, DC 20306 USA. [Aguilera, Nadine] Armed Forces Inst Pathol, Dept Hematopathol, Washington, DC 20306 USA. RP Summers, TA (reprint author), Walter Reed Army Med Ctr, Dept Anat Pathol, Bldg 2,6900 Georgia Ave NW, Washington, DC 20307 USA. EM thomas.a.summers@verizon.net NR 18 TC 3 Z9 4 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0303-6987 J9 J CUTAN PATHOL JI J. Cutan. Pathol. PD OCT PY 2009 VL 36 BP 25 EP 30 DI 10.1111/j.1600-0560.2008.01203.x PG 6 WC Dermatology; Pathology SC Dermatology; Pathology GA 496LT UT WOS:000269976300006 PM 19775391 ER PT J AU Barry, BE Ohland, MW AF Barry, Brock E. Ohland, Matthew W. TI Applied Ethics in the Engineering, Health, Business, and Law Professions: A Comparison SO JOURNAL OF ENGINEERING EDUCATION LA English DT Review DE assessment; curriculum; ethics ID STUDENTS PROPOSED BEHAVIOR; MEDICAL CURRICULUM; INTEGRATING ETHICS; MORAL JUDGMENT; EDUCATION; CLASSROOM; DILEMMAS; TAUGHT; IMPACT; VIRTUE AB BACKGROUND Applied ethics plays a critical role in engineering, health, business, and law. Applied ethics is currently a required component of the pre-practice education for these professions, yet the literature suggests that challenges remain in how we define, instruct, and assess professions-based ethics education. PURPOSE Based on the on going debate associated with the instruction and assessment of applied engineering ethics, an exploratory investigation was performed to determine what could be learned by looking across professions. SCOPE/METHOD Ethics, as an educational topic, can be very broad in scope. This study was limited to literature at the intersection of ethics terminology, historical development, instruction, and assessment within engineering, health, business, and law. Many references associated with each profession and the input of profession-specific content experts informed the literature survey. CONCLUSIONS Ethics within the engineering, health, business, and law professions have historically developed in isolation. Even case studies, which the engineering profession seems to have adopted from law, are framed differently within engineering. There are common lines of debate related to instructional methods, curricular methods, and instructor qualifications, but no profession has resolved these debates. A common trend in applied ethics research is a focus on assessment of student learning, rather than evaluation of instructional methods and/or curriculum incorporation methods. Assessment tools have been developed and applied widely for many years in several of the health cue subdisciplines, business and law. An engineering-specific applied-ethics assessment tool has recently been developed, but has yet to see extensive application. C1 [Barry, Brock E.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. [Ohland, Matthew W.] Purdue Univ, Sch Engn Educ, W Lafayette, IN 47907 USA. RP Barry, BE (reprint author), US Mil Acad, Dept Civil & Mech Engn, Mahan Hall,Bldg 752, West Point, NY 10996 USA. EM brock.barry@usma.edu; ohland@purdue.edu OI Ohland, Matthew/0000-0003-4052-1452 NR 120 TC 9 Z9 9 U1 3 U2 20 PU AMER SOC ENGINEERING EDUCATION PI WASHINGTON PA 1818 N ST, N W, STE 600, WASHINGTON, DC 20036 USA SN 1069-4730 J9 J ENG EDUC JI J. Eng. Educ. PD OCT PY 2009 VL 98 IS 4 BP 377 EP 388 PG 12 WC Education & Educational Research; Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA 526BT UT WOS:000272263200008 ER PT J AU Clayton, JD Bammann, DJ AF Clayton, J. D. Bammann, D. J. TI Finite Deformations and Internal Forces in Elastic-Plastic Crystals: Interpretations From Nonlinear Elasticity and Anharmonic Lattice Statics SO JOURNAL OF ENGINEERING MATERIALS AND TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article DE nonlinear elasticity; plasticity; lattice statics; dislocations; multiscale modeling ID VERSETZUNGEN UND EIGENSPANNUNGEN; DISCRETE DISCLINATIONS; DISLOCATION DENSITY; CONTINUUM THEORY; STORED ENERGY; LENGTH SCALE; DEFECTS; ELASTOPLASTICITY; STRESS; SOLIDS AB Large deformation kinematics and internal forces arising from defects in crystalline solids are addressed by a nonlinear kinematic description and multiscale averaging concepts. An element of crystalline material with spatially uniform properties and containing defects such as dislocation lines and loops is considered. The average deformation gradient for this element is decomposed multiplicatively into terms accounting for effects of dislocation flux, recoverable elastic stretch and rotation, and residual elastic deformation associated with self-equilibrating internal forces induced by defects. Two methods are considered for quantifying average residual elastic deformation: continuum elasticity and discrete lattice statics. Average residual elastic strains and corresponding average residual elastic volume changes are negligible in the context of linear elasticity or harmonic force potentials but are not necessarily inconsequential in the more general case of nonlinear elasticity or anharmonic interactions. [DOI: 10.1115/1.3183773] C1 [Clayton, J. D.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Bammann, D. J.] Mississippi State Univ, Ctr Adv Vehicular Syst, Starkville, MS 39762 USA. RP Clayton, JD (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM jclayton@arl.army.mil; bammann@cavs.msstate.edu RI Clayton, John/C-7760-2009 NR 71 TC 8 Z9 8 U1 0 U2 3 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-4289 J9 J ENG MATER-T ASME JI J. Eng. Mater. Technol.-Trans. ASME PD OCT PY 2009 VL 131 IS 4 AR 041201 DI 10.1115/1.3183773 PG 15 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 506ZR UT WOS:000270819100005 ER PT J AU Ingham, SC Vang, S Levey, B Fahey, L Norback, JP Fanslau, MA Senecal, AG Burnham, GM Ingham, BH AF Ingham, Steven C. Vang, Song Levey, Ben Fahey, Lisa Norback, John P. Fanslau, Melody A. Senecal, Andre G. Burnham, Greg M. Ingham, Barbara H. TI Predicting Behavior of Staphylococcus aureus, Salmonella Serovars, and Escherichia coli O157:H7 in Pork Products during Single and Repeated Temperature Abuse Periods SO JOURNAL OF FOOD PROTECTION LA English DT Article ID BACTERIAL-GROWTH; GROUND-BEEF; MODEL; O157-H7; FLORA; MEAT; PH AB Tools for predicting growth of Staphylococcus aureus, Salmonella, and Escherichia coli O157:1-17 (THERM; temperature history evaluation for raw meats) have been developed using ground pork and sausage. THERM tools have been tested with three types of pork sausage but not with other pork products or during sequential temperature abuse periods. We conducted inoculation studies (five strains each of S. aureus and/or Salmonella plus E. coli O157:H7) with simulated cooling of warm sausages, in-process warming of bratwurst, isothermal temperature abuse of pork frankfurter batter, and two sequential periods of 13, 15.6, or 21.1 degrees C temperature abuse of breakfast sausage, natural (additive-free) chops, and enhanced (phosphate solution-injected) loins. In sequential temperature abuse studies, a temperature abuse period (:524 h) occurred before and after either refrigeration (5 degrees C for 24 h), or freezing (-20 degrees C for 24 h) and thawing (24 h at 5 degrees C). Pathogen growth predictions from THERM developed using ground pork and sausage were compared with experimental results of 0 to 3.0 log CFU of growth. Across all temperature abuse conditions, qualitative predictions (growth versus no growth) made using the pork tool (n = 133) and the sausage tool (17 = 115) were accurate (51 and 50%, respectively), fail-safe (44 and 50%), or fail-dangerous (5 and 0%). Quantitative predictions from the two tools were accurate (29 and 22%, respectively), fail-safe (59 and 73%), or fail-dangerous (12 and 5%). Pathogen growth was greater during the second sequential temperature abuse period but not significantly so (P > 0.05). Both THERM tools provide useful qualitative predictions of pathogen growth in pork products during isolated or sequential temperature abuse events. C1 [Vang, Song; Levey, Ben; Fahey, Lisa; Norback, John P.; Ingham, Barbara H.] Univ Wisconsin, Dept Food Sci, Madison, WI 53706 USA. [Ingham, Steven C.] Wisconsin Dept Agr Trade & Consumer Protect, Div Food Safety, Madison, WI 53708 USA. [Fanslau, Melody A.] Fair Oaks Farms, Pleasant Prairie, WI 53158 USA. [Senecal, Andre G.; Burnham, Greg M.] USA, Natick Soldier Res Dev & Engn Ctr, Combat Feeding Directorate, Natick, MA 01760 USA. RP Ingham, BH (reprint author), Univ Wisconsin, Dept Food Sci, 1605 Linden Dr, Madison, WI 53706 USA. EM bhingham@wisc.edu FU USDA National Food Safety Initiative [2004-51110-02165]; U.S. Army Natick Soldier Research, Development & Engineering Center FX The authors gratefully acknowledge the USDA National Food Safety Initiative for funding the 2004 through 2006 portion of this work (project no. 2004-51110-02165), the U.S. Army Natick Soldier Research, Development & Engineering Center, Combat Feeding Directorate for funding the 2008 portion of this work, and Amy Haen, Ryan Algino, Efica Schoeller, and Melissa Talbot for laboratory assistance. NR 22 TC 3 Z9 3 U1 4 U2 8 PU INT ASSOC FOOD PROTECTION PI DES MOINES PA 6200 AURORA AVE SUITE 200W, DES MOINES, IA 50322-2863 USA SN 0362-028X J9 J FOOD PROTECT JI J. Food Prot. PD OCT PY 2009 VL 72 IS 10 BP 2114 EP 2124 PG 11 WC Biotechnology & Applied Microbiology; Food Science & Technology SC Biotechnology & Applied Microbiology; Food Science & Technology GA 503GM UT WOS:000270521600012 PM 19833035 ER PT J AU Jackson, JL Mallory, R AF Jackson, Jeffrey L. Mallory, Renee TI Aggression and Violence Among Elderly Patients, a Growing Health Problem SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Editorial Material ID DEMENTIA; PREVALENCE; WOMEN C1 [Jackson, Jeffrey L.; Mallory, Renee] Walter Reed Army Med Ctr, Dept Med, Div Gen Internal Med, Washington, DC 20307 USA. RP Jackson, JL (reprint author), Walter Reed Army Med Ctr, Dept Med, Div Gen Internal Med, Washington, DC 20307 USA. EM Jejackson@usuhs.mil NR 11 TC 2 Z9 2 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD OCT PY 2009 VL 24 IS 10 BP 1167 EP 1168 DI 10.1007/s11606-009-1099-1 PG 2 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA 506YQ UT WOS:000270814700015 ER PT J AU Kroschewski, H Sagripanti, JL Davidson, AD AF Kroschewski, Helga Sagripanti, Jose-Luis Davidson, Andrew D. TI Identification of amino acids in the dengue virus type 2 envelope glycoprotein critical to virus infectivity SO JOURNAL OF GENERAL VIROLOGY LA English DT Article ID FLAVIVIRUS MEMBRANE-FUSION; WEST-NILE; PROTEIN; REPLICATION; MATURATION; CELLS; GLYCOSYLATION; ENCEPHALITIS; MUTAGENESIS; ANTIBODIES AB The dengue virus envelope glycoprotein mediates virus attachment and entry and is the major viral antigen. The identification of 'critical' amino acids in the envelope glycoprotein that cannot be altered without loss of infectivity could have a major impact on the development of dengue virus vaccines and diagnostics. In this context, we determined whether six amino acids, previously predicted by computational analysis to play a critical role in the virus life cycle, were essential for virus viability. The effects of mutating the six 'critical' amino acids and a further seven 'neutral' amino acids were analysed by using a dengue virus type 2 infectious cDNA clone. Of the six critical amino acids, three (Asp-215, Pro-217 and His-244) were found to be essential for virus viability in mammalian and mosquito cells. C1 [Kroschewski, Helga; Davidson, Andrew D.] Univ Bristol, Sch Med Sci, Dept Cellular & Mol Med, Bristol BS8 1TD, Avon, England. [Sagripanti, Jose-Luis] USA, AMSRDECB RT, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Davidson, AD (reprint author), Univ Bristol, Sch Med Sci, Dept Cellular & Mol Med, Bristol BS8 1TD, Avon, England. EM andrew.davidson@bristol.ac.uk FU US Department of Defense Chemical and Biological Defense program administered by the Defense Threat Reduction Agency; Research and Technology Directorate, Edgewood Chemical Biological Center, Research Development and Engineering Command, US Army FX This work was supported by the US Department of Defense Chemical and Biological Defense program administered by the Defense Threat Reduction Agency and by In-House Laboratory Independent Research (ILIR) funds from the Research and Technology Directorate, Edgewood Chemical Biological Center, Research Development and Engineering Command, US Army. NR 29 TC 6 Z9 7 U1 0 U2 3 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 0022-1317 J9 J GEN VIROL JI J. Gen. Virol. PD OCT PY 2009 VL 90 BP 2457 EP 2461 DI 10.1099/vir.0.011486-0 PG 5 WC Biotechnology & Applied Microbiology; Virology SC Biotechnology & Applied Microbiology; Virology GA 502ZL UT WOS:000270499700017 PM 19587132 ER PT J AU Paudel, M Nelson, EJ Scharffenberg, W AF Paudel, Murari Nelson, E. James Scharffenberg, William TI Comparison of Lumped and Quasi-Distributed Clark Runoff Models Using the SCS Curve Number Equation SO JOURNAL OF HYDROLOGIC ENGINEERING LA English DT Article AB The Clark synthetic unit hydrograph and the Soil Conservation Service (SCS) curve number method has been used to simulate the rainfall and runoff behavior of a watershed for many years. Methodologies like Clark generally rely on the use of lumped or average rainfall and runoff parameters defined for the watershed, even though such parameters are spatially variable. In an attempt to leverage spatial parameters derived from geographic information, a modified Clark (ModClark) method or quasi-distributed model was developed for HEC-HMS. The ModClark method was initially developed to use the national network of WSR-88D radar (NEXRAD) rainfall data but few has been published on its application which is likely because of the difficulties in obtaining usable and reliable radar rainfall data and because of a lack of despisal preprocessing tools required to parameterize a ModClark simulation. While the original implementation and testing of the ModClark method required the use of NEXRAD data in specific formats, this study shows that it is possible to use any real or synthetic rainfall data whether it is spatially distributed or not. By not restricting the use of the distributed ModClark method to the use of spatially varying rainfall, distributed loss methods such as the commonly used SCS curve number can vary spatially over a grid and the effects of distributed watershed loss parameters can be analyzed with or without distributed rainfall. The implementation of the ModClark method in HEC-HMS is validated by comparing results to the Clark method using identical CN values. Further tests and examination of the SCS equation demonstrate that the runoff computed from distributed CN is always greater than the runoff computed from the traditional composite or area-averaged CN for ordinary ranges of rainfall depths. Moreover, by allowing a relatively fine grid resolution, the ModClark method determines the overall runoff from the watershed using a discharge weighted approach as opposed to weighted CN, which as reported in the National Engineering Handbook Part 630 is more accurate. C1 [Paudel, Murari; Nelson, E. James] Brigham Young Univ, Provo, UT 84602 USA. [Scharffenberg, William] USA, Corps Engineers Inst Water Resources, Hydrol Engn Ctr CEIWR HEC HH, Livermore, CA 95616 USA. RP Nelson, EJ (reprint author), Brigham Young Univ, 242 K CB, Provo, UT 84602 USA. EM mpaudel@et.byu.edu; jimn@byu.edu; william.scharffenberg@usace.army.mil NR 14 TC 13 Z9 13 U1 1 U2 6 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1084-0699 J9 J HYDROL ENG JI J. Hydrol. Eng. PD OCT PY 2009 VL 14 IS 10 BP 1098 EP 1106 DI 10.1061/(ASCE)HE.1943-5584.0000100 PG 9 WC Engineering, Civil; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA 494VX UT WOS:000269848500006 ER PT J AU Shi, XG Sturm, M Liston, GE Jordan, RE Lettenmaier, DP AF Shi, Xiaogang Sturm, Matthew Liston, Glen E. Jordan, Rachel E. Lettenmaier, Dennis P. TI SnowSTAR2002 Transect Reconstruction Using a Multilayered Energy and Mass Balance Snow Model SO JOURNAL OF HYDROMETEOROLOGY LA English DT Article ID MICROWAVE EMISSION MODEL; SEA-ICE; TEMPERATURE-GRADIENT; LAYERED SNOWPACKS; FOREST; ALASKA; COVER; SIMULATION; SOIL; METAMORPHISM AB The lateral and vertical variability of snow stratigraphy was investigated through the comparison of the measured profiles of snow density, temperature, and grain size obtained during the Snow Science Traverse-Alaska Region (SnowSTAR2002) 1200-km transect from Nome to Barrow with model reconstructions from the Snow Thermal Model (SNTHERM), a multilayered energy and mass balance snow model. Model profiles were simulated at the SnowSTAR2002 observation sites using the 40-yr European Centre for Medium-Range Weather Forecasts Re-Analysis (ERA-40) as meteorological forcing. ERA-40 precipitation was rescaled so that the total snow water equivalent (SWE) on the SnowSTAR2002 observation dates equaled the observed values. The mean absolute error (MAE) of measured and simulated snow properties shows that SNTHERM was able to produce good simulations for snowpack temperature but larger errors for grain size and density. A spatial similarity analysis using semivariograms of measured profiles shows that there is diverse lateral and vertical variability for snow properties along the SnowSTAR2002 transect resulting from differences in initial snow deposition, influenced by wind, vegetation, topography, and postdepositional mechanical and thermal metamorphism. The correlation length in snow density (42 km) is quite low, whereas it is slightly longer for snow grain size (125 km) and longer still for snow temperature (130 km). An important practical question that the observed and reconstructed profiles allow to be addressed is the implications of model errors in the observed snow properties for simulated microwave emissions signatures. The Microwave Emission Model for Layered Snowpacks (MEMLS) was used to simulate 19- and 37-GHz brightness temperatures. Comparison of SNTHERM-MEMLS and SnowSTAR2002-MEMLS brightness temperatures showed a very good match occurs at 19 GHz [a root-mean-square error (RMSE) of 1.5 K (8.7 K) for vertical (horizontal) polarization] and somewhat larger [5.9 K (6.2 K) for vertical (horizontal) polarization] at 37 GHz. These results imply that the simulation of snow microphysical profiles is a viable strategy for passive microwave satellite-based retrievals of SWE. C1 [Shi, Xiaogang; Lettenmaier, Dennis P.] Univ Washington, Dept Civil & Environm Engn, Seattle, WA 98195 USA. [Jordan, Rachel E.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Liston, Glen E.] Colorado State Univ, Dept Atmospher Sci, Ft Collins, CO 80523 USA. [Sturm, Matthew] USA, Cold Reg Res & Engn Lab, Ft Wainwright, AK USA. RP Lettenmaier, DP (reprint author), Univ Washington, Dept Civil & Environm Engn, 164 Wilcox Hall,Box 352700, Seattle, WA 98195 USA. EM dennisl@u.washington.edu RI lettenmaier, dennis/F-8780-2011 OI lettenmaier, dennis/0000-0003-3317-1327 FU National Science Foundation's Office of Polar Programs FX We appreciate the assistance of Ms. Nathalie Voisin of the University of Washington Land Surface Hydrology research group for retrieving the ERA-40 data. We especially want to thank Jon Holmgren, April Cheuvront, Eric Pyne, and Ken Tape for the taking measurements during SnowSTAR2002. Veco Polar Resources provided logistical support. The National Science Foundation's Office of Polar Programs provided financial support. NR 62 TC 7 Z9 7 U1 0 U2 7 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1525-755X J9 J HYDROMETEOROL JI J. Hydrometeorol. PD OCT PY 2009 VL 10 IS 5 BP 1151 EP 1167 DI 10.1175/2009JHM1098.1 PG 17 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 509QR UT WOS:000271033700005 ER PT J AU Moses, T Wagner, L Fleming, SD AF Moses, Tiffany Wagner, Lynn Fleming, Sherry D. TI TLR4-mediated Cox-2 expression increases intestinal ischemia/reperfusion-induced damage SO JOURNAL OF LEUKOCYTE BIOLOGY LA English DT Article DE eicosanoids; mice; innate autoimmunity ID TOLL-LIKE RECEPTORS; REPERFUSION INJURY; MESENTERIC ISCHEMIA; CUTTING EDGE; TLR4; MICE; COMPLEMENT; ACTIVATION; PATHWAY; LIVER AB Mesenteric IR induces significant inflammation and immune-mediated mucosal damage. TLR4 is a critical receptor in the induction of the inflammatory response and plays a role in intestinal homeostasis. To determine the role of TLR4 in IR-induced epithelial damage, we performed IR studies using TLR4(lps-def) and TLR4(lps-n) mice and analyzed mucosal damage and inflammation. We found that the absence of TLR4 or TLR4-induced signaling attenuated local mucosal damage with significantly decreased cytokine and eicosanoid secretion including PGE2 production. Similar results were seen in MyD88-/- mice. Wild-type mice treated with NS-398 (a Cox-2 inhibitor) not only decreased PGE2 production but also attenuated tissue damage. In contrast, PGE2 was not sufficient to induce damage in the TLR4(lps-def) mice. Together, these data indicate that TLR4 stimulation of Cox-2 activation of PGE2 production is necessary but not sufficient for intestinal IR-induced damage and inflammation. J. Leukoc. Biol. 86: 971-980; 2009. C1 [Moses, Tiffany; Fleming, Sherry D.] Kansas State Univ, Div Biol, Manhattan, KS 66506 USA. [Wagner, Lynn] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Fleming, SD (reprint author), Kansas State Univ, Div Biol, 18 Ackert Hall, Manhattan, KS 66506 USA. EM sdflemin@ksu.edu RI Ji, Haofeng/G-6206-2012 FU National Institutes of Health [AI061691, P20 RR017686, P20RR016475]; Institutional Development Award (IDeA) Program of the National Center for Research Resources; American Heart Association; Terry C. Johnson Center for Cancer Research; Division of Biology, KSU FX This work was supported by the following: National Institutes of Health grants AI061691, P20 RR017686, and P20RR016475 from the Institutional Development Award (IDeA) Program of the National Center for Research Resources, American Heart Association, Terry C. Johnson Center for Cancer Research, and the Division of Biology, KSU. The authors thank E. Dill and A. Humbarger for technical assistance. We also thank Drs. S. K. Chapes and S. Hoffman for critical review of the manuscript. NR 41 TC 31 Z9 36 U1 1 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0741-5400 J9 J LEUKOCYTE BIOL JI J. Leukoc. Biol. PD OCT PY 2009 VL 86 IS 4 BP 971 EP 980 DI 10.1189/jlb.0708396 PG 10 WC Cell Biology; Hematology; Immunology SC Cell Biology; Hematology; Immunology GA 501FS UT WOS:000270366500024 PM 19564573 ER PT J AU Bert, M Chaddic, J Perry, BD AF Bert, Melissa Chaddic, John Perry, Brian D. TI The Arctic in Transition-A Call to Action SO JOURNAL OF MARITIME LAW AND COMMERCE LA English DT Article ID OIL C1 [Perry, Brian D.] USA, Command & Gen Staff Coll, Washington, DC USA. NR 96 TC 1 Z9 1 U1 0 U2 1 PU JEFFERSON LAW BOOK COMPANY PI BALTIMORE PA 2100 HUNTINGDON AVE, BALTIMORE, MD 21211 USA SN 0022-2410 J9 J MARIT LAW COMMER JI J. Marit. Law Commer. PD OCT PY 2009 VL 40 IS 4 BP 481 EP 509 PG 29 WC International Relations; Law SC International Relations; Government & Law GA 545RR UT WOS:000273754700002 ER EF