FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Ragel, BT Klimo, P Martin, JE Teff, RJ Bakken, HE Armonda, RA AF Ragel, Brian T. Klimo, Paul, Jr. Martin, Jonathan E. Teff, Richard J. Bakken, Hans E. Armonda, Rocco A. TI Wartime decompressive craniectomy: technique and lessons learned SO NEUROSURGICAL FOCUS LA English DT Article DE battlefield; decompressive craniectomy; military ID PENETRATING CRANIOCEREBRAL INJURIES; MIDDLE CEREBRAL-ARTERY; SEVERE HEAD-INJURY; INTRACRANIAL HYPERTENSION; NEUROSURGICAL EXPERIENCE; TRAUMATIC BRAIN; BULLET VELOCITY; INFARCTION; LEBANON; WOUNDS AB Object. Decompressive craniectomy (DC) with dural expansion is a life-saving neurosurgical procedure performed for recalcitrant intracranial hypertension due to trauma, stroke, and a multitude of other etiologies. Illustratively, we describe technique and lessons learned using DC for battlefield trauma. Methods. Neurosurgical operative logs from service (October 2007 to September 2009) in Afghanistan that detail DC cases for trauma were analyzed. Illustrative examples of frontotemporoparietal and bifrontal DC that depict battlefield experience performing these procedures are presented with attention drawn to the L. G. Kempe hemispherectomy incision, brainstem decompression techniques, and dural onlay substitutes. Results. Ninety craniotomies were performed for trauma over the time period analyzed. Of these, 28 (31%) were DCs. Of the 28 DCs, 24 (86%) were frontotemporoparietal DCs, 7 (25%) were bifrontal DCs, and 2 (7%) were suboccipital DCs. Decompressive craniectomies were performed for 19 penetrating head injuries (13 gunshot wounds and 6 explosions) and 9 severe closed head injuries (6 war-related explosions and 3 others). Conclusions. Thirty-one percent of craniotomies performed for trauma were DCs. Battlefield neurosurgeons use DC to allow for safe transfer of neurologically ill patients to tertiary military hospitals, which can be located 8-18 hours from a war zone. The authors recommend the L. G. Kempe incision for blood supply preservation, large craniectomies to prevent brain strangulation over bone edges, minimal brain debridement, adequate brainstem decompression, and dural onlay substitutes for dural closure. (DOI: 10.3171/2010.3.FOCUS1028) C1 [Ragel, Brian T.] Oregon Hlth & Sci Univ, Dept Neurol Surg, Portland, OR 97239 USA. [Klimo, Paul, Jr.] Neurosurg Serv, Wright Patterson AFB, OH USA. [Martin, Jonathan E.] Connecticut Childrens Med Ctr, Div Neurosurg, Hartford, CT USA. [Teff, Richard J.] Brooke Army Med Ctr, Dept Neurosurg, Ft Sam Houston, TX 78234 USA. [Bakken, Hans E.] Madigan Army Med Ctr, Dept Neurosurg, Ft Lewis, WA USA. [Armonda, Rocco A.] Walter Reed Army Med Ctr, Dept Neurosurg, Washington, DC 20307 USA. RP Ragel, BT (reprint author), Oregon Hlth & Sci Univ, Dept Neurol Surg, Mail Code CH8N,3303 SW Bond Ave, Portland, OR 97239 USA. EM brian.ragel@gmail.com NR 26 TC 18 Z9 19 U1 0 U2 1 PU AMER ASSOC NEUROLOGICAL SURGEONS PI ROLLING MEADOWS PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA SN 1092-0684 J9 NEUROSURG FOCUS JI Neurosurg. Focus PD MAY PY 2010 VL 28 IS 5 AR E2 DI 10.3171/2010.3.FOCUS1028 PG 10 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 589ZU UT WOS:000277193600002 PM 20568936 ER PT J AU Stephens, FL Mossop, CM Bell, RS Tigno, T Rosner, MK Kumar, A Moores, LE Armonda, RA AF Stephens, Frederick L. Mossop, Correy M. Bell, Randy S. Tigno, Teodoro, Jr. Rosner, Michael K. Kumar, Anand Moores, Leon E. Armonda, Rocco A. TI Cranioplasty complications following wartime decompressive craniectomy SO NEUROSURGICAL FOCUS LA English DT Article DE cranioplasty; craniectomy; traumatic brain injury ID DELAYED CRANIOPLASTY; GRAFT INFECTION; TECHNICAL NOTE; BONE-GRAFTS; SKULL BONE; EXPERIENCE AB Object. In support of Operation Iraqi Freedom (OIF) and Operation Enduring Freedom-Afghanistan (OEF-A), military neurosurgeons in the combat theater are faced with the daunting task of stabilizing patients in such a way as to prevent irreversible neurological injury from cerebral edema while simultaneously allowing for prolonged transport stateside (5000-7000 miles). It is in this setting that decompressive craniectomy has become a mainstay of far-forward neurosurgical management of traumatic brain injury (TBI). As such, institutional experience with cranioplasty at the Walter Reed Army Medical Center (WRAMC) and the National Naval Medical Center (NNMC) has expanded concomitantly. Battlefield blast explosions create cavitary injury zones that often extend beyond the border of the exposed surface wound, and this situation has created unique reconstruction challenges not often seen in civilian TBI. The loss of both soft-tissue and skull base support along with the need for cranial vault reconstruction requires a multidisciplinary approach involving neurosurgery, plastics, oral-maxillofacial surgery, and ophthalmology. With this situation in mind, the authors of this paper endeavored to review the cranial reconstruction complications encountered in these combat-related injuries. Methods. A retrospective database review was conducted for all soldiers injured in OIF and OEF-A who had undergone decompressive craniectomy with subsequent cranioplasty between April 2002 and October 2008 at the WRAMC and NNMC. During this time, both facilities received a total of 408 OIF/OEF-A patients with severe head injuries; 188 of these patients underwent decompressive craniectomies in the theater before transfer to the US. Criteria for inclusion in this study consisted of either a closed or a penetrating head injury sustained in combat operations, resulting in the performance of a decompressive craniectomy and subsequent cranioplasty at either the WRAMC or NNMC. Excluded from the study were patients for whom primary demographic data could not be verified. Demographic data, indications for craniectomy, as well as preoperative, intraoperative, and postoperative parameters following cranioplasty, were recorded. Perioperative and postoperative complications were also recorded. Results. One hundred eight patients (male/female ratio 107: 1) met the inclusion criteria for this study, 93 with a penetrating head injury and 15 with a closed head injury. Explosive blast injury was the predominant mechanism of injury, occurring in 72 patients (67%). The average time that elapsed between injury and cranioplasty was 190 days (range 7-546 days). An overall complication rate of 24% was identified. The prevalence of perioperative infection (12%), seizure (7.4%), and extraaxial hematoma formation (7.4%) was noted. Twelve patients (11%) required prosthetic removal because of either extraaxial hematoma formation or infection. Eight of the 13 cases of infection involved cranioplasties performed between 90 and 270 days from the date of injury (p = 0.06). Conclusions. This study represents the largest to date in which cranioplasty and its complications have been evaluated in a trauma population that underwent decompressive craniectomy. The overall complication rate of 24% is consistent with rates reported in the literature (16-34%); however, the perioperative infection rate of 12% is higher than the rates reported in other studies. This difference is likely related to aspects of the initial injury pattern-such as skull base injury, orbitofacial fractures, sinus injuries, persistent fluid collection, and CSF leakage-which can predispose these patients to infection. (DOI: 10.3171/2010.2.FOCUS1026) C1 [Stephens, Frederick L.] Walter Reed Army Med Ctr, Dept Neurosurg, Washington, DC 20307 USA. Natl Naval Med Ctr, Dept Neurosurg, Bethesda, MD USA. RP Stephens, FL (reprint author), Walter Reed Army Med Ctr, Dept Neurosurg, Washington, DC 20307 USA. EM frederick.stephens@us.army.mil NR 16 TC 45 Z9 47 U1 0 U2 3 PU AMER ASSOC NEUROLOGICAL SURGEONS PI ROLLING MEADOWS PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA SN 1092-0684 J9 NEUROSURG FOCUS JI Neurosurg. Focus PD MAY PY 2010 VL 28 IS 5 AR E3 DI 10.3171/2010.2.FOCUS1026 PG 6 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 589ZU UT WOS:000277193600003 PM 20568943 ER PT J AU Teff, RJ AF Teff, Richard J. TI Use of neurosurgical decision-making and damage-control neurosurgery courses in the Iraq and Afghanistan conflicts: a surgeon's experience SO NEUROSURGICAL FOCUS LA English DT Article DE wartime neurosurgery; penetrating brain trauma; neurosurgical decision making; damage-control neurosurgery AB A shortage of Coalition neurological surgeons in the Iraq conflict prompted a creative approach to standardized neurosurgical care in 2007. After formulation of theater-wide clinical pathway guidelines, a need for standardized triage and neurological resuscitation was identified. The object was to establish a simple, reproducible course for medics, forward surgical and emergency room personnel, and other critical care providers to quickly standardize the ability of all deployed health care personnel to provide state-of-the-art neurosurgical triage and damage-control interventions. The methods applied were Microsoft PowerPoint presentations and hands-on learning. The year-long project resulted in more than 100 individuals being trained in neurosurgical decision making and in more than 15 surgeons being trained in damage-control neurosurgery. At the year's conclusion, hundreds of individuals received exceptional neurosurgical care from nonneurosurgical providers and a legacy course was left for future deployed providers to receive ongoing education at their own pace. (DOI: 10.3171/2010.2.FOCUS1017) C1 Brooke Army Med Ctr, Div Neurosurg, Ft Sam Houston, TX 78234 USA. RP Teff, RJ (reprint author), Brooke Army Med Ctr, Div Neurosurg, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM richard.teff@yahoo.com NR 0 TC 3 Z9 3 U1 0 U2 0 PU AMER ASSOC NEUROLOGICAL SURGEONS PI ROLLING MEADOWS PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA SN 1092-0684 J9 NEUROSURG FOCUS JI Neurosurg. Focus PD MAY PY 2010 VL 28 IS 5 AR E9 DI 10.3171/2010.2.FOCUS1017 PG 3 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 589ZU UT WOS:000277193600009 PM 20568949 ER PT J AU Grimme, JM Honda, M Wright, R Okuno, Y Rothenberg, E Mazin, AV Ha, T Spies, M AF Grimme, Jill M. Honda, Masayoshi Wright, Rebecca Okuno, Yusuke Rothenberg, Eli Mazin, Alexander V. Ha, Taekjip Spies, Maria TI Human Rad52 binds and wraps single-stranded DNA and mediates annealing via two hRad52-ssDNA complexes SO NUCLEIC ACIDS RESEARCH LA English DT Article ID REPLICATION PROTEIN-A; HOMOLOGOUS RECOMBINATION; BREAK REPAIR; SACCHAROMYCES-CEREVISIAE; YEAST RAD52; RAD51-MEDIATED RECOMBINATION; BIOCHEMICAL-PROPERTIES; BRANCH MIGRATION; GENE; RPA AB Rad52 promotes the annealing of complementary strands of DNA bound by replication protein A (RPA) during discrete repair pathways. Here, we used a fluorescence resonance energy transfer (FRET) between two fluorescent dyes incorporated into DNA substrates to probe the mechanism by which human Rad52 (hRad52) interacts with and mediates annealing of ssDNA-hRPA complexes. Human Rad52 bound ssDNA or ssDNA-hRPA complex in two, concentration-dependent modes. At low hRad52 concentrations, ssDNA was wrapped around the circumference of the protein ring, while at higher protein concentrations, ssDNA was stretched between multiple hRad52 rings. Annealing by hRad52 occurred most efficiently when each complementary DNA strand or each ssDNA-hRPA complex was bound by hRad52 in a wrapped configuration, suggesting homology search and annealing occur via two hRad52-ssDNA complexes. In contrast to the wild type protein, hRad52(RQK/AAA) and hRad52(1-212) mutants with impaired ability to bind hRPA protein competed with hRPA for binding to ssDNA and failed to counteract hRPA-mediated duplex destabilization highlighting the importance of hRad52-hRPA interactions in promoting efficient DNA annealing. C1 [Grimme, Jill M.; Honda, Masayoshi; Wright, Rebecca; Okuno, Yusuke; Spies, Maria] Univ Illinois, Dept Biochem, Urbana, IL 61801 USA. [Grimme, Jill M.] US Army Corps Engineers, Construct Engn Res Lab, Champaign, IL 61822 USA. [Rothenberg, Eli; Ha, Taekjip; Spies, Maria] Howard Hughes Med Inst, Urbana, IL 61801 USA. [Mazin, Alexander V.] Drexel Univ, Coll Med, Dept Biochem & Mol Biol, Philadelphia, PA 19102 USA. [Ha, Taekjip] Univ Illinois, Dept Phys, Urbana, IL 61801 USA. [Ha, Taekjip; Spies, Maria] Univ Illinois, Ctr Biophys & Computat Biol, Urbana, IL 61801 USA. RP Spies, M (reprint author), Univ Illinois, Dept Biochem, Urbana, IL 61801 USA. EM mspies@life.illinois.edu RI Ha, Taekjip/B-9506-2009 OI Ha, Taekjip/0000-0003-2195-6258 FU University of Illinois; American Cancer Society [RSG-09-182-01-DMC]; National Science Foundation [082265]]; National Institutes of Health [GM065367, CA100839, MH084119]; Leukemia and Lymphoma Society [1054-09]; Howard Hughes Medical Institute FX FUNDING; University of Illinois Startup funds and American Cancer Society [grant RSG-09-182-01-DMC to M. S.]; National Science Foundation under [grant no. 082265]; National Institutes of Health [grant no. GM065367 to TH]; National Institutes of Health [grants CA100839 and MH084119]; Leukemia and Lymphoma Society Scholar Award [1054-09 to A. V. M.]. Funding for open access charges: Howard Hughes Medical Institute. NR 59 TC 38 Z9 39 U1 0 U2 11 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0305-1048 J9 NUCLEIC ACIDS RES JI Nucleic Acids Res. PD MAY PY 2010 VL 38 IS 9 BP 2917 EP 2930 DI 10.1093/nar/gkp1249 PG 14 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 600NV UT WOS:000277994600021 PM 20081207 ER PT J AU Roy, D Arason, GA Chowdhury, B Mitra, A Calaf, GM AF Roy, D. Arason, G. A. Chowdhury, B. Mitra, A. Calaf, G. M. TI Profiling of cell cycle genes of breast cells exposed to etodolac SO ONCOLOGY REPORTS LA English DT Article DE cell cycle; breast cells; etodolac ID NONSTEROIDAL ANTIINFLAMMATORY DRUGS; CANCER-CELLS; EXPRESSION; RADIATION; LINE; REPLICATION; MECHANISMS; PREVENTION; INHIBITORS; P27(KIP1) AB Breast cancer represents the second leading cause of cancer-related deaths in the world. There is increasing evidence that perturbation of cell cycle regulation is an important contributing factor to various cancer progression stages. There are key checkpoints in the cell cycle involving various regulatory proteins. The relationship between these cell cycle regulatory proteins and cell cycle arrest by cyclooxygenase (COX) inhibitors during neoplastic progression remains largely unknown. Preclinical studies and epidemiological investigations have consistently shown that nonsteroidal anti-inflammatory drugs have some anti-proliferative and anti-oxidative stress response on various tumors. In this study, the effect of etodolac, a 1,8-diethyl-1,3,4,9-tetrahydropyrano (3,4-beta) indole-1-acetic acid on signaling pathways was investigated by examining the differential expression of various cell cycle regulatory protein genes. A human cell cycle gene array was used to profile the expression of 96 genes involved in the cell cycle regulation. Differentially expressed genes were highly altered by etodolac treatment. Twenty-six genes were up- and 20 down-regulated with 0.5 and 2 mM etodolac treatment. respectively. Seven genes (ATM, BAX, CCNA2, CDC27, RAD50 and p21) were prominently altered, and six (ATM, CCND2, CCNF, CDC20, CDK1A and RAD50) were commonly altered with both concentrations. This finding indicated that etodolac could play a critical role on cancer cells by inducing cell death. C1 [Roy, D.] CUNY, Dept Nat Sci, Hostos Coll, Bronx, NY 10451 USA. [Roy, D.; Arason, G. A.] Manhattan Coll, Grad Biotechnol Program, Riverdale, NY USA. [Chowdhury, B.] NCI, Human Retrovirus Sect, Vaccine Branch, NIH, Frederick, MD 21701 USA. [Chowdhury, B.] Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD USA. [Mitra, A.] Coll Mt St Vincent, Dept Chem, Riverdale, NY USA. [Calaf, G. M.] Columbia Univ, Ctr Radiol Res, Med Ctr, New York, NY 10032 USA. [Calaf, G. M.] Univ Tarapaca, Inst Alta Invest, Arica, Chile. RP Roy, D (reprint author), CUNY, Dept Nat Sci, Hostos Coll, Hostos Coll Campus,A-507E,475 Grand Concourse, Bronx, NY 10451 USA. EM droy@hostos.cuny.edu FU Manhattan College of New York FX This study was conducted as part of a Master's Degree thesis (GAA) and it was funded by the Graduate Biotechnology Program of the Manhattan College of New York. Thanks are given to FONDECYT 1080482 (GMC), CUNY Research Release Time (DR). The secretarial assistance of Danissa Barahona is greatly appreciated. We also thank Convenio de Desempeno UTA/MESESUP2 from Universidad de Tarapaca, Arica, Chile. NR 43 TC 4 Z9 4 U1 3 U2 3 PU SPANDIDOS PUBL LTD PI ATHENS PA POB 18179, ATHENS, 116 10, GREECE SN 1021-335X J9 ONCOL REP JI Oncol. Rep. PD MAY PY 2010 VL 23 IS 5 BP 1383 EP 1391 DI 10.3892/or_00000775 PG 9 WC Oncology SC Oncology GA 588MR UT WOS:000277075100027 PM 20372855 ER PT J AU Huang, WL Jain, FC AF Huang, Wenli Jain, Faquir C. TI Temperature insensitivity of the threshold current density in exciton-dominated wide energy gap quantum wire lasers SO OPTICAL ENGINEERING LA English DT Article DE quantum wire lasers; quantum dot lasers; threshold current density temperature dependence; excitons ID INGAN-ALGAN; SEMICONDUCTOR-LASERS; INTRABAND RELAXATION; WELL STRUCTURES; OPTICAL GAIN; DOT LASERS; ABSORPTION; LUMINESCENCE; TRANSITIONS; DEPENDENCE AB We present simulations on temperature dependence of the threshold current density (J(th)) in InGaN-AlGaN and ZnCdSe-ZnMgSSe quantum wire lasers having exciton transitions. We find that J(th) in a quantum wire laser is insensitive to temperature variation when exciton binding energies are in the range of 30 to 50 meV. This behavior is similar to quantum dot lasers having free carrier transitions. We show that the temperature dependence of the threshold current density is greatly reduced in lasers having exciton transitions in comparison to the ones having free carrier transitions. The reduced dependence of J(th) on the temperature is attributed to the inherent confinement of electron-hole pairs within the exciton radius along the wire axis, whereas the quantum wire cross section provides confinement of carriers in the plane perpendicular to the wire axis. The large exciton binding energies give rise to high exciton density of states and narrow spectral line width, thus confining the carriers into a pseudoquantum dot-like structure. The effect of exciton localization due to the randomness in quantum wire fabrication, causing exciton inhomogeneous line broadening, is also discussed. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3430578] C1 [Huang, Wenli] US Mil Acad, Photon Res Ctr, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. [Jain, Faquir C.] Univ Connecticut, Dept Elect & Comp Engn, Storrs, CT 06269 USA. RP Huang, WL (reprint author), US Mil Acad, Photon Res Ctr, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. EM wenli.huang@usma.edu FU ONR [N00014-02-1-0883, N00014-06-1-0016] FX This work is supported in part by ONR contracts N00014-02-1-0883 and N00014-06-1-0016 (Daniel Purdy, Program Director). The views expressed in this work are those of the authors and do not reflect the official policy or position of the United States Military Academy, the Department of the Army, or the Department of Defense or U. S. Government. NR 31 TC 1 Z9 1 U1 0 U2 5 PU SPIE-SOC PHOTOPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD MAY PY 2010 VL 49 IS 5 AR 054201 DI 10.1117/1.3430578 PG 7 WC Optics SC Optics GA 622BB UT WOS:000279632000017 ER PT J AU Qiu, LA Goossen, KW Heider, D O'Brien, DJ Wetzel, ED AF Qiu, Liang Goossen, Keith W. Heider, Dirk O'Brien, Daniel J. Wetzel, Eric D. TI Nonpigtail optical coupling to embedded fiber Bragg grating sensors SO OPTICAL ENGINEERING LA English DT Article DE fiber optical sensors; fiber Bragg grating; free-space coupling; embedded optical fiber; smart structures; structural monitoring ID MICROSENSORS; MULTIMODE; CONCRETE AB In recent decades, optical fiber has proven useful for many sensor applications. Specifically, fiber Bragg grating (FBG) sensors have shown great utility for integrity management and environmental sensing of composite structures. One major drawback of FBG sensors, however, is the lack of a robust, nonpigtail technique for coupling to the embedded FBG sensor. In this paper, a novel method of free-space passive coupling of light into FBG sensors is described. An angled 45-deg mirror integrated directly into the fiber was used as an input coupling technique. We investigated the application of this approach to both single- and multimode glass fibers containing FBGs. For multimode FBGs, we studied the grating's uniformity across the fiber diameter and its effect on normal free-space coupling. In single- mode investigations, a novel method of coupling to the sensor via splicing a multimode fiber to a single- mode FBG (SMFBG) was developed. Finally, free-space coupling to an embedded SMFBG was employed to measure the tensile strain. Excellent agreement was found between the FBG and conventional electrical resistance strain gauges. We conclude that this coupling method might eliminate the need for pigtailing by providing a more robust coupling method for FBG sensors. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3421552] C1 [Qiu, Liang; Goossen, Keith W.] Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA. [Heider, Dirk] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. [O'Brien, Daniel J.; Wetzel, Eric D.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Qiu, LA (reprint author), Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA. EM qiulion@udel.edu FU Army Research Laboratory [W911NF-06-2-011] FX This research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement number W911NF-06-2-011. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U. S. Government. The U. S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. NR 20 TC 4 Z9 4 U1 0 U2 5 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 EI 1560-2303 J9 OPT ENG JI Opt. Eng. PD MAY PY 2010 VL 49 IS 5 AR 054402 DI 10.1117/1.3421552 PG 8 WC Optics SC Optics GA 622BB UT WOS:000279632000020 ER PT J AU Pritchett, TM Sun, WF Zhang, BG Ferry, MJ Li, YJ Haley, JE Mackie, DM Shensky, W Mott, AG AF Pritchett, Timothy M. Sun, Wenfang Zhang, Bingguang Ferry, Michael J. Li, Yunjing Haley, Joy E. Mackie, David M. Shensky, William, III Mott, Andrew G. TI Excited-state absorption of a bipyridyl platinum(II) complex with alkynyl-benzothiazolylfluorene units SO OPTICS LETTERS LA English DT Article ID PHOTOPHYSICS AB The singlet excited-state lifetime of a bipyridyl platinum(II) complex containing two alkynyl-benzothiazolylfluorene units was determined to be 145+/-105 ps by fitting femtosecond transient difference absorption data, and the triplet quantum yield was measured to be 0.14. A ground-state absorption cross section of 6.1 x 10(-19) cm(2) at 532 nm was deduced from UV-visible absorption data. Excited-state absorption cross sections of (6.7+/-0.1) x 10(-17) cm(2) (singlet) and (4.6+/-0.1) x 10(-16) cm(2) (triplet) were obtained by using a five-level dynamic model to fit open-aperture Z scans at picosecond and nanosecond pulse widths and a variety of pulse energies. For this complex, the ratio of the triplet excited-state absorption cross section to the ground-state absorption cross section-long used as a figure of merit for reverse saturable absorbers-thus stands at 754, to our knowledge the largest ever reported at 532 nm wavelength. (C) 2010 Optical Society of America C1 [Pritchett, Timothy M.; Ferry, Michael J.; Mackie, David M.; Shensky, William, III; Mott, Andrew G.] USA, Res Lab, RDRL SEE M, Adelphi, MD 20783 USA. [Sun, Wenfang; Zhang, Bingguang; Li, Yunjing] N Dakota State Univ, Dept Chem & Mol Biol, Fargo, ND 58108 USA. [Haley, Joy E.] USAF, Res Lab, Mat & Mfg Directorate, Wright Patterson AFB, OH 45433 USA. [Haley, Joy E.] Universal Energy Syst Inc, Dayton, OH 45432 USA. RP Pritchett, TM (reprint author), USA, Res Lab, RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM timothy.pritchett1@us.army.mil RI Shensky, William/J-7012-2014 FU Army Research Laboratory [W911NF-06-2-0032]; National Science Foundation (NSF) [CHE-0449598] FX W. Sun acknowledges financial support from the Army Research Laboratory (W911NF-06-2-0032) and the National Science Foundation (NSF) (CAREER CHE-0449598). NR 19 TC 24 Z9 24 U1 0 U2 9 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD MAY 1 PY 2010 VL 35 IS 9 BP 1305 EP 1307 DI 10.1364/OL.35.001305 PG 3 WC Optics SC Optics GA 590IU UT WOS:000277219800001 PM 20436550 ER PT J AU Fridman, M Nixon, M Dubinskii, M Friesem, AA Davidson, N AF Fridman, Moti Nixon, Micha Dubinskii, Mark Friesem, Asher A. Davidson, Nir TI Fiber amplification of radially and azimuthally polarized laser light SO OPTICS LETTERS LA English DT Article ID BEAMS; GENERATION; MODE; PLATE AB The results of amplifying either radially or azimuthally polarized light with a fiber amplifier are presented. Experimental results reveal that more than 85% polarization purity can be retained at the output even with 40 dB amplification and that efficient conversion of the amplified light to linear polarization can be obtained. (C) 2010 Optical Society of America C1 [Fridman, Moti; Nixon, Micha; Friesem, Asher A.; Davidson, Nir] Weizmann Inst Sci, Dept Phys Complex Syst, IL-76100 Rehovot, Israel. [Dubinskii, Mark] USA, Res Lab, Adelphi, MD 20783 USA. RP Fridman, M (reprint author), Weizmann Inst Sci, Dept Phys Complex Syst, IL-76100 Rehovot, Israel. EM moti.fridman@weizmann.ac.il NR 15 TC 9 Z9 9 U1 2 U2 5 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD MAY 1 PY 2010 VL 35 IS 9 BP 1332 EP 1334 DI 10.1364/OL.35.001332 PG 3 WC Optics SC Optics GA 590IU UT WOS:000277219800010 PM 20436559 ER PT J AU Divakov, AK Mescheryakov, YI Zhigacheva, NI Barakhtin, BK Gooch, WA AF Divakov, A. K. Mescheryakov, Yu. I. Zhigacheva, N. I. Barakhtin, B. K. Gooch, W. A. TI Spall strength of titanium alloys SO PHYSICAL MESOMECHANICS LA English DT Article DE titanium alloys; spall strength; phase transition; microstructure; shock loading ID ZIRCONIUM AB A series of high-velocity impact tests of impactors and targets of varying acoustic impedance, including Al - Ti, steel - Ti and Ti - Ti combinations, reveals a beta <->omega to phase transition in alpha+beta Ti alloys under shock loading. The presence of the omega-phase is confirmed by X-ray diffraction analysis of Ti-4.5Al-3Mo-IV alloy specimens loaded with an impactor at different impact velocities. The experiments show that at an impact velocity greater than similar to 500 m/s, spall fracture occurs earlier than the omega -> x reverse transition (where x is the alpha-phase, or the beta-phase, or their mixture) takes place during the decay of the compression pulse. Hence, the spall fracture in the material develops in the presence of the omega-phase whose dynamic strength is much smaller than that of the beta-phase. For the spall occurring after the to omega -> x reverse transition, the spall strength of the alloy increases by 25 %. C1 [Divakov, A. K.; Mescheryakov, Yu. I.; Zhigacheva, N. I.] Inst Problems Mech Engn RAS, St Petersburg 199178, Russia. [Barakhtin, B. K.] Cent Res Inst Struct Mat Prometey, St Petersburg 191015, Russia. [Gooch, W. A.] USA, Res Lab, Aberdeen, MD 21005 USA. RP Mescheryakov, YI (reprint author), Inst Problems Mech Engn RAS, St Petersburg 199178, Russia. EM ym38@mail.ru NR 17 TC 3 Z9 3 U1 3 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1029-9599 J9 PHYS MESOMECH JI Phys. Mesomech. PD MAY-AUG PY 2010 VL 13 IS 3-4 BP 113 EP 123 DI 10.1016/j.physme.2010.07.002 PG 11 WC Mechanics; Materials Science, Characterization & Testing SC Mechanics; Materials Science GA 654WU UT WOS:000282202600002 ER PT J AU Cruz, AR Pillay, A Zuluaga, AV Ramirez, LG Duque, JE Aristizabal, GE Fiel-Gan, MD Jaramillo, R Trujillo, R Valencia, C Jagodzinski, L Cox, DL Radolf, JD Salazar, JC AF Cruz, Adriana R. Pillay, Allan Zuluaga, Ana V. Ramirez, Lady G. Duque, Jorge E. Aristizabal, Gloria E. Fiel-Gan, Mary D. Jaramillo, Roberto Trujillo, Rodolfo Valencia, Carlos Jagodzinski, Linda Cox, David L. Radolf, Justin D. Salazar, Juan C. TI Secondary Syphilis in Cali, Colombia: New Concepts in Disease Pathogenesis SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID PALLIDUM SUBSP PALLIDUM; VIRULENT TREPONEMA-PALLIDUM; POLYMERASE-I GENE; OUTER-MEMBRANE; PREGNANT-WOMEN; UNITED-STATES; SOUTH-AFRICA; RISK-FACTORS; HEPATITIS-B; WHOLE-BLOOD AB Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia. To be eligible for participation, study subjects were required to have cutaneous lesions consistent with SS, a reactive Rapid Plasma Reagin test (RPR-titer >= 1:4), and a confirmatory treponemal test (Fluorescent Treponemal Antibody Absorption test-FTA-ABS). Most subjects enrolled were women (64.9%), predominantly Afro-Colombian (38.6%) or mestizo (56.1%), and all were of low socio-economic status. Three (5.3%) subjects were newly diagnosed with HIV infection at study entry. The duration of signs and symptoms in most patients (53.6%) was less than 30 days; however, some patients reported being symptomatic for several months (range 5-240 days). The typical palmar and plantar exanthem of SS was the most common dermal manifestation (63%), followed by diffuse hypo-or hyperpigmented macules and papules on the trunk, abdomen and extremities. Three patients had patchy alopecia. Whole blood (WB) samples and punch biopsy material from a subset of SS patients were assayed for the presence of Tp DNA polymerase I gene (polA) target by real-time qualitative and quantitative PCR methods. Twelve (46%) of the 26 WB samples studied had quantifiable Tp DNA (ranging between 194.9 and 1954.2 Tp polA copies/ml blood) and seven (64%) were positive when WB DNA was extracted within 24 hours of collection. Tp DNA was also present in 8/12 (66%) skin biopsies available for testing. Strain typing analysis was attempted in all skin and WB samples with detectable Tp DNA. Using arp repeat size analysis and tpr RFLP patterns four different strain types were identified (14d, 16d, 13d and 22a). None of the WB samples had sufficient DNA for typing. The clinical and microbiologic observations presented herein, together with recent Cali syphilis seroprevalence data, provide additional evidence that venereal syphilis is highly endemic in this region of Colombia, thus underscoring the need for health care providers in the region to be acutely aware of the clinical manifestations of SS. This study also provides, for the first time, quantitative evidence that a significant proportion of untreated SS patients have substantial numbers of circulating spirochetes. How Tp is able to persist in the blood and skin of SS patients, despite the known presence of circulating treponemal opsonizing antibodies and the robust pro-inflammatory cellular immune responses characteristic of this stage of the disease, is not fully understood and requires further study. C1 [Cruz, Adriana R.; Zuluaga, Ana V.; Ramirez, Lady G.; Duque, Jorge E.; Trujillo, Rodolfo; Valencia, Carlos] CIDEIM, Cali, Colombia. [Pillay, Allan; Cox, David L.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Aristizabal, Gloria E.] Secretaria Salud Publ Municipal, Cali, Colombia. [Fiel-Gan, Mary D.] Hartford Hosp, Dept Pathol, Hartford, CT 06115 USA. [Jaramillo, Roberto] Fdn Clin Valle del Lili, Cali, Colombia. [Jagodzinski, Linda] Walter Reed Army Inst Res, Rockville, MD USA. [Radolf, Justin D.] Univ Connecticut, Ctr Hlth, Dept Med, Farmington, CT USA. [Radolf, Justin D.] Univ Connecticut, Ctr Hlth, Dept Genet & Dev Biol, Farmington, CT USA. [Salazar, Juan C.] Univ Connecticut, Ctr Hlth, Dept Pediat, Farmington, CT USA. [Salazar, Juan C.] Connecticut Childrens Med Ctr, Div Infect Dis, Hartford, CT USA. RP Cruz, AR (reprint author), CIDEIM, Cali, Colombia. EM jsalaza@ccmckids.org FU Public Health Service [K23 AI62439, 5R03TW008023, AI-26756, AI-38894]; Connecticut Children's Medical Center (CCMC); COLCIENCIAS [222940820554] FX This work was supported in part by Public Health Service grants K23 AI62439 (JCS), 5R03TW008023 (JCS and AC), AI-26756 (JR), AI-38894 (JR), Connecticut Children's Medical Center's (CCMC) Arrison and Burr Curtis Research Funds (JCS) and COLCIENCIAS grant # 222940820554 (AC). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 78 TC 21 Z9 23 U1 1 U2 15 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1935-2727 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD MAY PY 2010 VL 4 IS 5 AR e690 DI 10.1371/journal.pntd.0000690 PG 13 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 608QO UT WOS:000278601000020 PM 20502522 ER PT J AU Hensley, LE Mulangu, S Asiedu, C Johnson, J Honko, AN Stanley, D Fabozzi, G Nichol, ST Ksiazek, TG Rollin, PE Wahl-Jensen, V Bailey, M Jahrling, PB Roederer, M Koup, RA Sullivan, NJ AF Hensley, Lisa E. Mulangu, Sabue Asiedu, Clement Johnson, Joshua Honko, Anna N. Stanley, Daphne Fabozzi, Giulia Nichol, Stuart T. Ksiazek, Thomas G. Rollin, Pierre E. Wahl-Jensen, Victoria Bailey, Michael Jahrling, Peter B. Roederer, Mario Koup, Richard A. Sullivan, Nancy J. TI Demonstration of Cross-Protective Vaccine Immunity against an Emerging Pathogenic Ebolavirus Species SO PLOS PATHOGENS LA English DT Article ID NONHUMAN-PRIMATES; RHESUS-MONKEYS; HEMORRHAGIC-FEVER; VIRUS INFECTION; CELL RESPONSES; T-LYMPHOCYTES; REPLICATION; VECTORS; GLYCOPROTEIN; GENERATION AB A major challenge in developing vaccines for emerging pathogens is their continued evolution and ability to escape human immunity. Therefore, an important goal of vaccine research is to advance vaccine candidates with sufficient breadth to respond to new outbreaks of previously undetected viruses. Ebolavirus (EBOV) vaccines have demonstrated protection against EBOV infection in nonhuman primates (NHP) and show promise in human clinical trials but immune protection occurs only with vaccines whose antigens are matched to the infectious challenge species. A 2007 hemorrhagic fever outbreak in Uganda demonstrated the existence of a new EBOV species, Bundibugyo (BEBOV), that differed from viruses covered by current vaccine candidates by up to 43% in genome sequence. To address the question of whether cross-protective immunity can be generated against this novel species, cynomolgus macaques were immunized with DNA/rAd5 vaccines expressing ZEBOV and SEBOV glycoprotein (GP) prior to lethal challenge with BEBOV. Vaccinated subjects developed robust, antigen-specific humoral and cellular immune responses against the GP from ZEBOV as well as cellular immunity against BEBOV GP, and immunized macaques were uniformly protected against lethal challenge with BEBOV. This report provides the first demonstration of vaccine-induced protective immunity against challenge with a heterologous EBOV species, and shows that Ebola vaccines capable of eliciting potent cellular immunity may provide the best strategy for eliciting cross-protection against newly emerging heterologous EBOV species. C1 [Hensley, Lisa E.; Johnson, Joshua; Honko, Anna N.; Wahl-Jensen, Victoria] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Mulangu, Sabue; Asiedu, Clement; Stanley, Daphne; Fabozzi, Giulia; Bailey, Michael; Sullivan, Nancy J.] NIAID, Biodef Res Sect, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [Nichol, Stuart T.; Ksiazek, Thomas G.; Rollin, Pierre E.] Ctr Dis Control & Prevent, Special Pathogens Branch, Div Viral & Rickettsial Dis, Atlanta, GA USA. [Jahrling, Peter B.] NIAID, Integrated Res Facil, NIH, Bethesda, MD 20892 USA. [Roederer, Mario; Koup, Richard A.] NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. RP Hensley, LE (reprint author), USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. EM nsullivan@nih.gov OI Johnson, Joshua/0000-0002-5677-3841; Honko, Anna/0000-0001-9165-148X FU Vaccine Research Center, NIAID, National Institutes of Health FX This work was supported in part by the Intramural Research Program of the Vaccine Research Center, NIAID, National Institutes of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 34 TC 60 Z9 62 U1 0 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1553-7366 J9 PLOS PATHOG JI PLoS Pathog. PD MAY PY 2010 VL 6 IS 5 AR e1000904 DI 10.1371/journal.ppat.1000904 PG 9 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA 610TL UT WOS:000278759900023 PM 20502688 ER PT J AU Song, H Hwang, J Yi, H Ulrich, RL Yu, Y Nierman, WC Kim, HS AF Song, Han Hwang, Junghyun Yi, Hyojeong Ulrich, Ricky L. Yu, Yan Nierman, William C. Kim, Heenam Stanley TI The Early Stage of Bacterial Genome-Reductive Evolution in the Host SO PLOS PATHOGENS LA English DT Article ID MICROBIAL GENE IDENTIFICATION; BURKHOLDERIA-PSEUDOMALLEI; CAUSATIVE AGENT; ALPHA-PROTEOBACTERIA; MALLEI; SEQUENCE; MELIOIDOSIS; EXPRESSION; STRATEGIES; GLANDERS AB The equine-associated obligate pathogen Burkholderia mallei was developed by reductive evolution involving a substantial portion of the genome from Burkholderia pseudomallei, a free-living opportunistic pathogen. With its short history of divergence (similar to 3.5 myr), B. mallei provides an excellent resource to study the early steps in bacterial genome reductive evolution in the host. By examining 20 genomes of B. mallei and B. pseudomallei, we found that stepwise massive expansion of IS (insertion sequence) elements ISBma1, ISBma2, and IS407A occurred during the evolution of B. mallei. Each element proliferated through the sites where its target selection preference was met. Then, ISBma1 and ISBma2 contributed to the further spread of IS407A by providing secondary insertion sites. This spread increased genomic deletions and rearrangements, which were predominantly mediated by IS407A. There were also nucleotide-level disruptions in a large number of genes. However, no significant signs of erosion were yet noted in these genes. Intriguingly, all these genomic modifications did not seriously alter the gene expression patterns inherited from B. pseudomallei. This efficient and elaborate genomic transition was enabled largely through the formation of the highly flexible IS-blended genome and the guidance by selective forces in the host. The detailed IS intervention, unveiled for the first time in this study, may represent the key component of a general mechanism for early bacterial evolution in the host. C1 [Song, Han; Hwang, Junghyun; Yi, Hyojeong; Kim, Heenam Stanley] Korea Univ, Coll Med, Dept Med, Seoul 136705, South Korea. [Ulrich, Ricky L.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Yu, Yan; Nierman, William C.] J Craig Venter Inst, Rockville, MD USA. [Nierman, William C.] George Washington Univ, Sch Med, Dept Biochem & Mol Biol, Washington, DC USA. RP Kim, HS (reprint author), Korea Univ, Coll Med, Dept Med, Seoul 136705, South Korea. EM hstanleykim@korea.ac.kr FU Ministry of Education, Science & Technology in the Republic of Korea [2009K000516, 20090058514, K20601000002-09E0100-00210]; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services [NIAID N01-AI30071] FX This work was supported by grants 2009K000516 from the 21C Frontier Microbial Genomics & Applications Center Program, 20090058514 from the Basic Research Program, and the K20601000002-09E0100-00210 from the Korea Foundation for International Cooperation of Science & Technology (KICOS), all of which are from the Ministry of Education, Science & Technology in the Republic of Korea to HSK. Sequencing and annotation of most of the Bp and Bm strains was supported in whole or part with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services under contract number NIAID N01-AI30071. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 44 TC 42 Z9 42 U1 1 U2 9 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1553-7366 J9 PLOS PATHOG JI PLoS Pathog. PD MAY PY 2010 VL 6 IS 5 AR e1000922 DI 10.1371/journal.ppat.1000922 PG 10 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA 610TL UT WOS:000278759900041 PM 20523904 ER PT J AU Weeks, SR McAuliffe, CL DuRussel, D Pasquina, PF AF Weeks, Sharon R. McAuliffe, Caitlin L. DuRussel, David Pasquina, Paul F. TI Physiological and Psychological Fatigue in Extreme Conditions: The Military Example SO PM&R LA English DT Article AB The extreme conditions causing fatigue in military service members in combat and combat training deserve special consideration. The collective effects of severe exertion, limited caloric intake, and sleep deprivation, combined with the inherent stressors of combat, lead to both physiological and psychological fatigue that may significantly impair performance. Studies of combat training have revealed a myriad of endocrine, cognitive, and neurological changes that occur as a result of exposure to extreme conditions. Further contributory effects of multiple military deployments, post-traumatic stress disorder, and traumatic brain injury may also influence both the susceptibility to and expression of fatigue states. Further research is needed to explore these effects to enhance military readiness and performance as well as prevent injuries. PM R 2010;2:438-441 C1 [Weeks, Sharon R.; McAuliffe, Caitlin L.; DuRussel, David; Pasquina, Paul F.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. RP Pasquina, PF (reprint author), Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM paul.pasquina@us.army.mil OI Weeks, Sharon/0000-0002-9952-9136 FU Military Amputee Research Program; Center for Neuroscience and Regenerative Medicine; Center for Neuroscience and Regenerative Medicine (CNRM) at the Uniformed Services University of the Health Sciences FX Funded by the Military Amputee Research Program; Funded by the Center for Neuroscience and Regenerative Medicine; The views expressed in this article are those of the authors and do not reflect the official policy of the Department of the Army, Department of Defense, or the United States Government. The authors would also like to acknowledge the support of the Center for Neuroscience and Regenerative Medicine (CNRM) at the Uniformed Services University of the Health Sciences NR 29 TC 9 Z9 10 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1934-1482 J9 PM&R JI PM&R PD MAY PY 2010 VL 2 IS 5 BP 438 EP 441 DI 10.1016/j.pmrj.2010.03.023 PG 4 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA V23SB UT WOS:000208361400015 PM 20656625 ER PT J AU Vizzard, JW Capron, TA AF Vizzard, James W. Capron, Timothy A. TI Exporting General Petraeus's Counterinsurgency Doctrine: An Assessment of the Adequacy of Field Manual 3-24 and the US Government's Implementation SO PUBLIC ADMINISTRATION REVIEW LA English DT Article AB The authors review the U.S. Army's field manual on counterinsurgency, consider the doctrine and tactics that it espouses, and survey its current critics. They present specific examples of its application and conclude that while counterinsurgency does achieve results, the U. S. government lacks a strategic doctrinal framework for implementing counterinsurgency elsewhere. This shortcoming urgently needs to be addressed in a meaningful way by political leaders. C1 [Vizzard, James W.] USA, Washington, DC 20310 USA. [Capron, Timothy A.] Calif State Univ Sacramento, Sacramento, CA 95819 USA. RP Vizzard, JW (reprint author), USA, Washington, DC 20310 USA. EM james.vizzard@gmail.com; capron@csus.edu NR 17 TC 1 Z9 1 U1 1 U2 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0033-3352 J9 PUBLIC ADMIN REV JI Public Adm. Rev. PD MAY-JUN PY 2010 VL 70 IS 3 BP 485 EP 493 PG 9 WC Public Administration SC Public Administration GA 588OU UT WOS:000277082500014 ER PT J AU Collen, J Greenburg, D Holley, A King, C Roop, S Hnatiuk, O AF Collen, Jacob Greenburg, David Holley, Aaron King, Christopher Roop, Stuart Hnatiuk, Oleh TI Racial discordance in spirometry comparing four commonly used reference equations to the National Health and Nutrition Examination Study III SO RESPIRATORY MEDICINE LA English DT Article DE Spirometry; African-American; Discordance; Pulmonary function test ID FORCED EXPIRATORY VOLUME; REFERENCE VALUES; LUNG-FUNCTION; VITAL CAPACITY; UNITED-STATES; AFRICAN; MANAGEMENT; ADULTS AB Diagnosing lung function abnormalities requires application of the appropriate reference equation for a given patient population. Current guidelines recommend the National Health and Examination Study III data set for evaluating patients in the United States. In Caucasian patients, relying on older reference equations, as opposed to those derived from the NHANES Ill data set, will often result in a different interpretation of a patient's spirometry. The present study assessed whether similar discordance would occur in African-American patients. A cross-sectional analysis of African-American patients undergoing spirometry testing at our hospital was performed. Patients were classified as normal, restricted, obstructed or mixed based upon the ATS/ERS guidelines, using Crapo, Knudson, Morris, Glindmeyer, and NHANES III prediction equations. Differences in classification were evaluated. 4463 subjects were identified, with a mean age of 49.6. Discordance in interpretation was most common when results from prediction equations by Morris, Knudson, and Glindmeyer were compared to NHANES III (24.6%, 26.4%, and 20.1%, respectively). Discordance was less common when comparing Crapo to NHANES III (12.8%). There was a tendency for Knudson, Morris and Glindmeyer to under classify restriction, and for Crapo, Morris, and Glindmeyer to over classify obstruction. There is significant discordance in interpretation when spirometry for African-American patients is referenced to equations published by Crapo, Morris, Knudson, and Glindmeyer, compared to NHANES III. Published by Elsevier Ltd. C1 [Collen, Jacob; Holley, Aaron; King, Christopher; Roop, Stuart] USA, Walter Reed Army Med Ctr, Washington, DC 20310 USA. [Greenburg, David] USA, Madigan Army Med Ctr, Tacoma, WA USA. [Hnatiuk, Oleh] NIH, Bethesda, MD 20892 USA. RP Collen, J (reprint author), USA, Walter Reed Army Med Ctr, Washington, DC 20310 USA. EM jacob.collen@amedd.army.mil; dgreenburg@usuhs.mil; aaron.holley@amedd.army.mil; christopher.king@amedd.army.mil; stuart.roop@amedd.army.mil; hnatiuko@nhlbi.nih.gov NR 31 TC 2 Z9 2 U1 0 U2 0 PU W B SAUNDERS CO LTD PI LONDON PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND SN 0954-6111 J9 RESP MED JI Respir. Med. PD MAY PY 2010 VL 104 IS 5 BP 705 EP 711 DI 10.1016/j.rmed.2009.11.001 PG 7 WC Cardiac & Cardiovascular Systems; Respiratory System SC Cardiovascular System & Cardiology; Respiratory System GA 604MD UT WOS:000278282200012 PM 19931442 ER PT J AU Nurenberg, JR Schleifer, SJ Vijayalakshmy, P AF Nurenberg, Jeffry R. Schleifer, Steven J. Vijayalakshmy, Patrick TI Curtailing antipsychotic polypharmacy in a state institution: review and update of a performance improvement intervention SO SALUD I CIENCIA LA Spanish DT Article DE antipsychotic polypharmacy; state psychiatric hospital; intervention; restriction AB A moderate intensity performance improvement initiative at a state psychiatric hospital to reduce antipsychotic polypharmacy was undertaken in November 2001. The Chief of Psychiatry met with each of 14 psychiatrists, comparing their rates of polypharmacy with that of their peers, and asked all to attempt a 10% decrease in antipsychotic polypharmacy. Polypharmacy fell significantly from 40 percent of patients treated with antipsychotics in November 2001 to 31 percent in August 2002. Reduced polypharmacy was not related to baseline rates or associated with increased use of other psychotropic medications. Rates of polypharmacy in 2006-2008 appear to have reverted to the 40% range, however. During a period of institutional change, possibly associated with increased clinical acuity, antipsychotic polypharmacy approached 67%. While an only modestly intensive intervention by leadership appeared to reduce polypharmacy in 2001, studies are required to determine whether such efforts can be efficacious under different more acute clinical conditions. C1 [Nurenberg, Jeffry R.] Psychiat Greystone Pk Psychiat Hosp, Newark, NJ USA. [Nurenberg, Jeffry R.; Schleifer, Steven J.] Univ Med & Dent New Jersey, Newark, NJ 07103 USA. [Vijayalakshmy, Patrick] Brooke Army Med Ctr, San Antonio, TX USA. RP Nurenberg, JR (reprint author), Greystone Pk Psychiat Hosp, Morris Plains, NJ 07950 USA. EM Jeffry.Nurenberg@dhs.state.nj.us NR 2 TC 0 Z9 0 U1 0 U2 0 PU SOC IBEROAMERICANA INFORMACION CIENTIFICA-S I I C PI BUENOS AIRES PA AVE BELGRANO 430-C1092AAR, BUENOS AIRES, 00000, ARGENTINA SN 1667-8982 J9 SALUD CIENC JI Salud Cienc. PD MAY PY 2010 VL 17 IS 5 BP 432 EP 434 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 694NV UT WOS:000285305800006 ER PT J AU Sturm, M AF Sturm, Matthew TI Arctic Plants Feel the Heat SO SCIENTIFIC AMERICAN LA English DT Article ID ALASKA C1 USA, Washington, DC 20310 USA. RP Sturm, M (reprint author), USA, Washington, DC 20310 USA. NR 5 TC 4 Z9 5 U1 0 U2 4 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0036-8733 J9 SCI AM JI Sci.Am. PD MAY PY 2010 VL 302 IS 5 BP 66 EP 73 DI 10.1038/scientificamerican0510-66 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 586QJ UT WOS:000276926100026 PM 20443380 ER PT J AU Wang, Y Chen, LQ Liu, ZK Mathaudhu, SN AF Wang, Y. Chen, L. -Q. Liu, Z. -K. Mathaudhu, S. N. TI First-principles calculations of twin-boundary and stacking-fault energies in magnesium SO SCRIPTA MATERIALIA LA English DT Article DE Magnesium; Interfaces; Twinning; First-principles calculation ID HCP METALS; PSEUDOPOTENTIALS AB The interfacial energies of twin boundaries and stacking faults in metal magnesium have been calculated using first-principles supercell approach. Four types of twin boundaries and two types of stacking faults are investigated, namely, those due to the (10 (1) over bar1) mirror reflection, the (10 (1) over bar1) mirror glide, the (10 (1) over bar2) mirror reflection, the (10 (1) over bar2) mirror glide, the I1 stacking fault and the I2 stacking fault. The effects of supercell size on the calculated interfacial energies are examined. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Wang, Y.; Chen, L. -Q.; Liu, Z. -K.] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. [Mathaudhu, S. N.] USA, Mat & Mfg Sci Div, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Wang, Y (reprint author), Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. EM yuw3@psu.edu RI Mathaudhu, Suveen/B-4192-2009; Chen, LongQing/I-7536-2012; Wang, Yi/D-1032-2013; Liu, Zi-Kui/A-8196-2009 OI Chen, LongQing/0000-0003-3359-3781; Liu, Zi-Kui/0000-0003-3346-3696 FU U.S. Army Research Laboratory [W911NF-08-2-0064]; Office of Science of the U.S. Department of Energy [DE-AC02-05CH11231]; National Science Foundation [DMR-9983532, DMR-0122638, DMR-0205232, DMR-0510180]; Materials Simulation Center; Graduate Education and Research Services at the Pennsylvania State University FX The financial support from U.S. Army Research Laboratory under Contract W911NF-08-2-0064 is especially acknowledged. This research used resources of the National Energy Research Scientific Computing Center, which is supported by the Office of Science of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. Calculations were also conducted at the LION clusters at the Pennsylvania State University (supported in part by National Science Foundation Grants Nos. DMR-9983532, DMR-0122638, and DMR-0205232, and in part by the Materials Simulation Center and the Graduate Education and Research Services at the Pennsylvania State University). Additional funding from the National Science Foundation through Grant DMR-0510180 is gratefully acknowledged. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the U.S. Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distributed reprints for Government purposes not withstanding any copyright notation hereon. NR 21 TC 58 Z9 60 U1 12 U2 63 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6462 J9 SCRIPTA MATER JI Scr. Mater. PD MAY PY 2010 VL 62 IS 9 BP 646 EP 649 DI 10.1016/j.scriptamat.2010.01.014 PG 4 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 573SA UT WOS:000275933700004 ER PT J AU Berman, OL Gumbs, G Folkes, PA AF Berman, Oleg L. Gumbs, Godfrey Folkes, Patrick A. TI Collective properties of excitons in the presence of a two-dimensional electron gas SO SOLID STATE COMMUNICATIONS LA English DT Article DE Quantum wells; Semiconductors; Electron-electron interactions; Phase transitions ID COUPLED QUANTUM-WELLS; PHASE-TRANSITIONS; GROUND-STATE; SYSTEMS; CONDENSATION; HOLE; PHOTOLUMINESCENCE; ENERGY AB We have studied the collective properties of two-dimensional (2D) excitons immersed within a quantum well which contains 2D excitons and a two-dimensional electron gas (2DEG). We have also analyzed the excitations for a system of 2D dipole excitons with spatially separated electrons and holes in a pair of quantum wells (CQWs) when one of the wells contains a 2DEG Calculations of the superfluid density and the Kosterlitz-Thouless (K-T) phase transition temperature for the 2DEG-exciton system in a quantum well have shown that the K-T transition temperature increase with increasing exciton density and that it might be possible to have fast long-range transport of excitons The superfluid density and the K-T transition temperature for dipole excitons in CQWs in the presence of a 2DEG in one of the wells Increases with increasing inter-well separation. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Berman, Oleg L.] CUNY, New York City Coll Technol, Dept Phys, Brooklyn, NY 11201 USA. [Gumbs, Godfrey] CUNY Hunter Coll, Dept Phys & Astron, New York, NY 10065 USA. [Folkes, Patrick A.] USA, Res Lab, Adelphi, MD 20783 USA. RP Berman, OL (reprint author), CUNY, New York City Coll Technol, Dept Phys, 300 Jay St, Brooklyn, NY 11201 USA. FU PSC CUNY [621360040]; AFRL [FA9453-07-C-0207] FX O.L.B. would like to acknowledge the support by PSC CUNY grant 621360040 GG would like to acknowledge the support by contract FA9453-07-C-0207 of AFRL NR 31 TC 0 Z9 0 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-1098 J9 SOLID STATE COMMUN JI Solid State Commun. PD MAY PY 2010 VL 150 IS 17-18 BP 832 EP 835 DI 10.1016/j.ssc.2010.02.012 PG 4 WC Physics, Condensed Matter SC Physics GA 584VM UT WOS:000276781600007 ER PT J AU Fonda, SJ Kedziora, RJ Vigersky, RA Bursell, SE AF Fonda, Stephanie J. Kedziora, Richard J. Vigersky, Robert A. Bursell, Sven-Erik TI Combining iGoogle and Personal Health Records to Create a Prototype Personal Health Application for Diabetes Self-Management SO TELEMEDICINE JOURNAL AND E-HEALTH LA English DT Article DE e-health; technology; medical records ID RANDOMIZED CONTROLLED-TRIAL; GLUCOSE MONITORING-SYSTEM; QUALITATIVE RESEARCH; ETHNICALLY DIVERSE; IDEATEL PROJECT; CARE; USABILITY; INTERNET; IMPLEMENTATION; INFORMATICS AB Objective: The aim of this project is to create a prototype for a personal health application (PHA) for patients (i.e., consumers) with diabetes by employing a user-centered design process. This article describes the design process for and resulting architecture, workflow, and functionality of such a PHA. Materials and Methods: For the design process, we conducted focus groups with people who have diabetes (n=21) to ascertain their needs for a PHA. We then developed a prototype in response to these needs, and through additional focus groups and step-by-step demonstrations for people with diabetes as well as healthcare providers, we obtained feedback about the prototype. The feedback led to changes in the PHA's presentation and function. Results: Focus group participants said they wanted a tool that could give them timely, readily available information on how diabetes-related domains interact, how their behaviors affect them, and what to do next. Thus, the prototype PHA is Internet-based, retrieves data for diabetes self-management from a personal health record, displays those data using gadgets in the consumer's iGoogle page, and makes the data available to a decision-support component that provides lifestyle-oriented advice. Manipulation of the data enables consumers to anticipate the results of future actions and to see interrelationships. Conclusions: A user-centered design process resulted in a PHA that uses technology that is publicly available, employs a personal health record, and is Internet based. This PHA can provide the backbone for a decision support system that can bring together the cornerstones of diabetes self-management and integrate them into the life of the person with diabetes. C1 [Fonda, Stephanie J.; Vigersky, Robert A.] Walter Reed Army Med Ctr, Dept Med, Serv Endocrinol, Washington, DC 20307 USA. [Kedziora, Richard J.] Estenda Solut Inc, Conshohocken, PA USA. [Bursell, Sven-Erik] Univ Hawaii, John A Burns Sch Med, Telehlth Res Inst, Honolulu, HI 96822 USA. RP Fonda, SJ (reprint author), Walter Reed Army Med Ctr, Dept Med, Serv Endocrinol, 6900 Georgia Ave NW,Bldg 2,Room 7D, Washington, DC 20307 USA. EM fondasj@gmail.com FU Robert Wood Johnson Foundation [59888, 63415, 64533]; California HealthCare Foundation FX This work was supported by grant 59888 (to S.J.F. and S.-E.B.) and grants 63415 and 64533 (to S.J.F.) from the Robert Wood Johnson Foundation and the California HealthCare Foundation. NR 32 TC 5 Z9 5 U1 2 U2 14 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-5627 J9 TELEMED J E-HEALTH JI Telemed. J. e-Health PD MAY PY 2010 VL 16 IS 4 BP 480 EP 489 DI 10.1089/tmj.2009.0122 PG 10 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 601ZI UT WOS:000278107000049 PM 20455776 ER PT J AU Lebeda, FJ Cer, RZ Mudunuri, U Stephens, R Singh, BR Adler, M AF Lebeda, Frank J. Cer, Regina Z. Mudunuri, Uma Stephens, Robert Singh, Bal Ram Adler, Michael TI The Zinc-Dependent Protease Activity of the Botulinum Neurotoxins SO TOXINS LA English DT Review DE catalysis; energy; k(cat); K-m; superactivation AB The botulinum neurotoxins (BoNT, serotypes A-G) are some of the most toxic proteins known and are the causative agents of botulism. Following exposure, the neurotoxin binds and enters peripheral cholinergic nerve endings and specifically and selectively cleaves one or more SNARE proteins to produce flaccid paralysis. This review centers on the kinetics of the Zn-dependent proteolytic activities of these neurotoxins, and briefly describes inhibitors, activators and factors underlying persistence of toxin action. Some of the structural, enzymatic and inhibitor data that are discussed here are available at the botulinum neurotoxin resource, BotDB (http://botdb.abcc.ncifcrf.gov). C1 [Lebeda, Frank J.] USA, Med Res & Mat Command, Ft Detrick, MD 21702 USA. [Cer, Regina Z.; Mudunuri, Uma; Stephens, Robert] NCI Frederick, Bioinformat Support Grp, Adv Biomed Comp Ctr, Informat Syst Program,SAIC Frederick Inc, Ft Detrick, MD 21702 USA. [Singh, Bal Ram] Univ Massachusetts, Botulinum Res Ctr, Dartmouth, MA 02747 USA. [Adler, Michael] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Lebeda, FJ (reprint author), USA, Med Res & Mat Command, Ft Detrick, MD 21702 USA. EM frank.lebeda@amedd.army.mil; cerr@mail.nih.gov; mudunuriu@mail.nih.gov; stephensr@mail.nih.gov; bsingh@umassd.edu; michael.adler@us.army.mil FU Defense Threat Reduction Agency, Joint Science and Technology Office-Chemical Biological Defense [3.10043-07-RD-B, T.T.0011-06-RC_B]; National Cancer Institute, National Institutes of Health [HHSN261200800001E] FX This study was supported by the Defense Threat Reduction Agency, Joint Science and Technology Office-Chemical Biological Defense project 3.10043-07-RD-B (FJL), and project T.T.0011-06-RC_B (MA) and by the National Cancer Institute, National Institutes of Health under contract HHSN261200800001E. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U. S. Army or the Department of Health and Human Services. The mention of trade names, commercial products, or organizations does not imply endorsement by the U. S. Government. Electronic versions for some of the citations used in the analysis for this paper were obtained at the National Library of Medicine, the Uniform Services University of the Health Sciences and the Sheridan Libraries at Johns Hopkins University. NR 100 TC 10 Z9 12 U1 1 U2 11 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2072-6651 J9 TOXINS JI Toxins PD MAY PY 2010 VL 2 IS 5 BP 978 EP 997 DI 10.3390/toxins2050978 PG 20 WC Toxicology SC Toxicology GA V24UI UT WOS:000208434900004 PM 22069621 ER PT J AU Deters, KA Brown, RS Carter, KM Boyd, JW Eppard, MB Seaburg, AG AF Deters, Katherine A. Brown, Richard S. Carter, Kathleen M. Boyd, James W. Eppard, M. Brad Seaburg, Adam G. TI Performance Assessment of Suture Type, Water Temperature, and Surgeon Skill in Juvenile Chinook Salmon Surgically Implanted with Acoustic Transmitters SO TRANSACTIONS OF THE AMERICAN FISHERIES SOCIETY LA English DT Article ID TELEMETRY TRANSMITTERS; SWIMMING PERFORMANCE; ATLANTIC SALMON; RAINBOW-TROUT; GROWTH; MORTALITY; SURVIVAL; FISH; WILD AB This study assessed performance of seven suture types in subyearling Chinook salmon Oncorhynchus tshawytscha implanted with acoustic microtransmitters and held at two water temperatures (12 degrees C and 17 degrees C). Nonabsorbable (Ethilon) and absorbable (Monocryl) monofilament sutures and nonabsorbable (Nurolon and silk) and absorbable (Vicryl, Vicryl Plus, and Vicryl Rapide) braided sutures were used to close incisions in Chinook salmon. When differences existed among suture types, tag and suture retention were generally highest for monofilament sutures. Wound inflammation and ulceration were generally lower for Ethilon and Monocryl than for most of the braided sutures. In this study, Nurolon (braided) often resulted in low wound inflammation and ulceration, although suture retention was poor. Generally, fish held in 12 degrees C water had more desirable postsurgery healing characteristics (i.e., higher tag and suture retention; lower incision openness, wound inflammation, and ulceration) at 7 and 14 d postsurgery than fish held in 17 degrees C water. On days 34 and 63, tag retention remained high among fish in 12 degrees C water, while suture retention decreased dramatically in both water temperatures. We found a significant effect of surgeon on tag and suture retention, wound inflammation and ulceration, and incision openness. Surgeons in this study were initially thought to have similar surgical proficiency based on their extensive previous experience. However, surgeons who had received feedback on their previous surgical technique performed better in this study. Results indicate that surgical training (i.e., feedback) and perhaps aptitude, rather than surgeon experience alone, may be as important as suture type in influencing the retention of sutures and tags. The overall results support the conclusion that Monocryl is the best suture material for closing incisions created during surgical implantation of acoustic microtransmitters in subyearling Chinook salmon. Future research should include testing different suturing patterns and knotting techniques as well as the number of knots required for different incision lengths. C1 [Deters, Katherine A.; Brown, Richard S.; Carter, Kathleen M.; Boyd, James W.] Pacific NW Natl Lab, Richland, WA 99352 USA. [Eppard, M. Brad] USA, Corps Engineers, Portland, OR 97204 USA. [Seaburg, Adam G.] Univ Washington, Columbia Basin Res, Sch Aquat & Fishery Sci, Seattle, WA 98101 USA. RP Deters, KA (reprint author), Pacific NW Natl Lab, POB 999, Richland, WA 99352 USA. EM katherine.deters@pnl.gov NR 23 TC 39 Z9 41 U1 1 U2 8 PU AMER FISHERIES SOC PI BETHESDA PA 5410 GROSVENOR LANE SUITE 110, BETHESDA, MD 20814-2199 USA SN 0002-8487 J9 T AM FISH SOC JI Trans. Am. Fish. Soc. PD MAY PY 2010 VL 139 IS 3 BP 888 EP 899 DI 10.1577/T09-043.1 PG 12 WC Fisheries SC Fisheries GA 595UQ UT WOS:000277639200022 ER PT J AU Serkin, FB Soderdahl, DW Cullen, J Chen, YM Hernandez, J AF Serkin, Faye B. Soderdahl, Douglas W. Cullen, Jennifer Chen, Yongmei Hernandez, Javier TI Patient risk stratification using Gleason score concordance and upgrading among men with prostate biopsy Gleason score 6 or 7 SO UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS LA English DT Article; Proceedings Paper CT 3rd Annual Bladder Cancer Think Tank CY AUG, 2008 CL Mont Tremblant, CANADA DE Prostate cancer; Gleason sum; Discordance; Survival ID RADICAL PROSTATECTOMY; NEEDLE-BIOPSY; CANCER; ANTIGEN; DISCREPANCIES; SPECIMENS; ACCURACY; FEATURES; VOLUME; GRADE AB Purpose: To define the impact of discordant Gleason sum (GS) between prostate biopsy (Pbx) tissue and radical prostatectomy (RP) specimen among men initially diagnosed with Gleason 6 or 7 prostate adenocarcinoma. Materials and methods: We evaluated patients diagnosed with GS 6 or 7 and treated primarily with RP. We defined the frequency of GS discordance between Pbx and RP pathology reports. We analyzed pretreatment parameters associated with GS discordance and compared immediate postprostatectomy outcome variables across patient groups defined by their GS and concordance. We then conducted survival analysis for biochemical recurrence across patient groups defined by their GS and concordance status. Results: Among patients with GS 6 on Pbx, 681/1,847 (36.86%) patients were upgraded to GS 7 or higher after RP. Surgical margin, capsular involvement, seminal vesicle, and nodal involvement status were more favorable in patients with concordant Pbx and RP specimen with GS 6 (P < 0.0001). Patients with smaller transrectal ultrasound (TRUS) prostate volume were found to have higher PSA densities and were more likely to be upgraded at RP. Multivariate survival analysis also predicted fewer biochemical recurrence events over time in men with concordant Pbx tissue and RP specimen of GS 6 vs. 6/7 or 7/7 (P = 0.0025) controlling for other relevant covariates. Conclusions: GS discordance between Pbx tissue and RP specimens among prostate cancer patients initially diagnosed with either GS 6 or 7 adenocarcinoma of the prostate is substantial. This discordance has potential clinical significance in predicting oncologic outcomes. Published by Elsevier Inc. C1 [Serkin, Faye B.; Soderdahl, Douglas W.; Hernandez, Javier] Brooke Army Med Ctr, Dept Surg, Urol Serv, Ft Sam Houston, TX 78234 USA. [Cullen, Jennifer; Chen, Yongmei] CPDR, Rockville, MD 20852 USA. RP Hernandez, J (reprint author), Brooke Army Med Ctr, Dept Surg, Urol Serv, Ft Sam Houston, TX 78234 USA. EM javier.hernandez@amedd.army.mil NR 18 TC 11 Z9 11 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1078-1439 EI 1873-2496 J9 UROL ONCOL-SEMIN ORI JI Urol. Oncol.-Semin. Orig. Investig. PD MAY-JUN PY 2010 VL 28 IS 3 BP 302 EP 307 DI 10.1016/j.urolonc.2008.09.030 PG 6 WC Oncology; Urology & Nephrology SC Oncology; Urology & Nephrology GA 601ED UT WOS:000278040100013 PM 19117774 ER PT J AU Anderson, BA Maslia, ML Caparoso, JL Ausdemore, D Aral, MM AF Anderson, B. A. Maslia, M. L. Caparoso, J. L. Ausdemore, D. Aral, M. M. TI Stochastic Analysis of Pesticide Transport in the Shallow Groundwater of Oatland Island, Georgia, USA SO WATER QUALITY EXPOSURE AND HEALTH LA English DT Article DE Analytical solutions; Monte Carlo simulation; Pesticide transport; Probabilistic analysis; Screening-level model; United States; Wetlands AB Analytical models, when used in stochastic analysis mode, may provide an effective tool for making informed management decisions for simplified environmental systems. This approach was used to evaluate migration of an organochlorine pesticide plume in a shallow, unconfined aquifer underlying a barrier island in coastal Georgia, USA. The contaminant plume at the site consists of four isomers of benzene hexachloride (BHC), also known as hexachlorocyclohexane (HCH). The deterministic analysis conducted at the site, which used calibrated, single-value input parameters, indicates that the contaminant plume will not reach wetlands that are downgradient of the source. Given the uncertainties involved in the deterministic analysis, this outcome was not considered to be sufficient to make effective management decisions at the site. Subsequently, probabilistic analysis using a range of input parameter values was conducted to estimate the risk that the pesticide plume would reach the downgradient wetlands. The two-stage Monte Carlo analysis that was conducted indicates the probability that contaminant levels will exceed the detection limit of BHC (0.044 micrograms per liter) at the wetlands increases from 1 percent to a maximum of 13 percent during the period 2005-2065. This represents an 87% or greater confidence level that the pesticide plume will not reach the wetlands. This outcome was used to inform environmental management decisions at the site. The modeling analysis was conducted using the publicly available analytical contaminant transport analysis system (ACTS) software. C1 [Anderson, B. A.; Maslia, M. L.] Agcy Tox Subst & Dis Registry, Atlanta, GA 30341 USA. [Caparoso, J. L.] US Army Ctr Hlth Promot & Prevent Med Europe, Landstuhl, Germany. [Ausdemore, D.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Aral, M. M.] Georgia Inst Technol, Sch Civil & Environm Engn, Multimedia Environm Simulat Lab, Atlanta, GA 30332 USA. RP Anderson, BA (reprint author), Agcy Tox Subst & Dis Registry, 4770 Buford Highway NE,Mail Stop F-59, Atlanta, GA 30341 USA. EM baanderson@cdc.gov FU Agency for Toxic Substances and Disease Registry; Centers for Disease Control and Prevention FX This project was funded by the Agency for Toxic Substances and Disease Registry and the Centers for Disease Control and Prevention. The authors acknowledge their colleagues at ATSDR, including Rene Suarez-Soto, John Mann, and Susan Moore, for providing assistance and advice on this project. Caryl Wipperfurth from the U.S. Geological Survey, Atlanta, Georgia assisted with the preparation of illustrations. NR 39 TC 1 Z9 1 U1 0 U2 2 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1876-1658 EI 1876-1666 J9 WATER QUAL EXPOS HEA JI Water Qual. Expos. Health PD MAY PY 2010 VL 2 IS 1 BP 47 EP 64 DI 10.1007/s12403-010-0023-6 PG 18 WC Water Resources SC Water Resources GA V35HF UT WOS:000209140300003 ER PT J AU Link, A Chen, MJ Powers, SE Grimberg, SJ AF Link, Angela Chen, Manjiang Powers, Susan E. Grimberg, Stefan J. TI Effects of growth conditions and NAPL presence on transport of Pseudomonas saccharophilia P15 through porous media SO WATER RESEARCH LA English DT Article DE Bacterial transport; Non-aqueous phase liquid; Growth state; Bacterial adhesion; MATH assay ID BACTERIAL TRANSPORT; MICROBIAL ADHESION; SOIL; DEPOSITION; PHENANTHRENE; SURFACTANTS; HYDROCARBON; ADSORPTION; HEXADECANE; STRENGTH AB Extensive research has been done to characterize transport of bacteria in porous media; however, little is understood on how the presence of non-aqueous phase liquids (NAPLs) coupled with the growth state and carbon source of bacteria affect bacterial transport. The objective of this research is to quantify the bacterial adhesion of Pseudomonas saccharophilia P15 (P15), which is known to biodegrade polycyclic aromatic hydrocarbons (PAH) and to interact with coal tars, within a NAPL-water-mineral system. Through a series of short-pulse column experiments, the transport and deposition of P15 in porous media (quartz sand) as a function of growth state and carbon sources (peptone and naphthalene), and in the presence and absence of residual NAPL (hexadecane), is measured and evaluated. Coating 20% of the quartz grain with hexadecane as a model NAPL increased the retention of P15 by as much as a factor of 26 as compared to the retention exhibited in quartz sand with no NAPL present. P15 grown on peptone and in the late exponential growth state exhibited a greater amount of deposition within the hexadecane column than when it was grown on naphthalene or was in early exponential growth phase. During early growth stage P15 grown on naphthalene adhered stronger to the porous media compared to when grown on peptone. Results were compared with results of MATH assays, where P15 partitioning to hexadecane was evaluated as a function of carbon source and growth state. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Link, Angela; Chen, Manjiang; Powers, Susan E.; Grimberg, Stefan J.] Clarkson Univ, Dept Civil & Environm Engn, Potsdam, NY 13699 USA. [Link, Angela] US Army Corps Engineers, Kansas City, KS USA. [Chen, Manjiang] GAI Consultants Inc, Orlando, FL USA. RP Grimberg, SJ (reprint author), Clarkson Univ, Dept Civil & Environm Engn, Potsdam, NY 13699 USA. EM grimberg@clarkson.edu FU National Science Foundation [BES-9981494, BES 0217134, DGE-0234623] FX The writers thank M. Borkovec from the University of Geneva, Switzerland, for supplying the computer program used for calculating the fit of the advection-dispersion-reactive equation to the experimental data. This work was made possible by grants from the National Science Foundation (BES-9981494, BES 0217134 and DGE-0234623). Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation. NR 33 TC 2 Z9 2 U1 1 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD MAY PY 2010 VL 44 IS 9 BP 2793 EP 2802 DI 10.1016/j.watres.2010.02.012 PG 10 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA 599AK UT WOS:000277882000011 PM 20219231 ER PT J AU Cho, JH Chen, IR AF Cho, Jin-Hee Chen, Ing-Ray TI Modeling and analysis of intrusion detection integrated with batch rekeying for dynamic group communication systems in mobile ad hoc networks SO WIRELESS NETWORKS LA English DT Article DE Group communication systems; Mobile ad hoc networks; Batch rekeying; Intrusion detection; Stochastic Petri net; Group key management; Security; Performance analysis ID SECURE GROUP COMMUNICATIONS; WIRELESS NETWORKS; KEY MANAGEMENT; PEER GROUPS; AGREEMENT AB We investigate performance characteristics of secure group communication systems (GCSs) in mobile ad hoc networks that employ intrusion detection techniques for dealing with insider attacks tightly coupled with rekeying techniques for dealing with outsider attacks. The objective is to identify optimal settings including the best intrusion detection interval and the best batch rekey interval under which the system lifetime (mean time to security failure) is maximized while satisfying performance requirements. We develop a mathematical model based on stochastic Petri net to analyze tradeoffs between security and performance properties, when given a set of parameter values characterizing operational and environmental conditions of a GCS instrumented with intrusion detection tightly coupled with batch rekeying. We compare our design with a baseline system using intrusion detection integrated with individual rekeying to demonstrate the effectiveness. C1 [Chen, Ing-Ray] Virginia Tech, Dept Comp Sci, Blacksburg, VA 24061 USA. [Cho, Jin-Hee] USA, Computat & Informat Sci Directorate, Res Lab, Adelphi, MD USA. RP Chen, IR (reprint author), Virginia Tech, Dept Comp Sci, Blacksburg, VA 24061 USA. EM jinhee.cho@us.army.mil; irchen@vt.edu NR 36 TC 3 Z9 3 U1 0 U2 3 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1022-0038 EI 1572-8196 J9 WIREL NETW JI Wirel. Netw. PD MAY PY 2010 VL 16 IS 4 BP 1157 EP 1173 DI 10.1007/s11276-009-0194-x PG 17 WC Computer Science, Information Systems; Engineering, Electrical & Electronic; Telecommunications SC Computer Science; Engineering; Telecommunications GA 593KT UT WOS:000277454200019 ER PT J AU Fritz, JM Thackeray, A Childs, JD Brennan, GP AF Fritz, Julie M. Thackeray, Anne Childs, John D. Brennan, Gerard P. TI A randomized clinical trial of the effectiveness of mechanical traction for sub-groups of patients with low back pain: study methods and rationale SO BMC MUSCULOSKELETAL DISORDERS LA English DT Article ID LUMBAR DISC HERNIATION; OSWESTRY DISABILITY INDEX; PHYSICAL-THERAPISTS; SUBGROUP ANALYSES; SAMPLE-SIZE; SCIATICA; MANAGEMENT; HEALTH; CARE; QUESTIONNAIRE AB Background: Patients with signs of nerve root irritation represent a sub-group of those with low back pain who are at increased risk of persistent symptoms and progression to costly and invasive management strategies including surgery. A period of non-surgical management is recommended for most patients, but there is little evidence to guide non-surgical decision-making. We conducted a preliminary study examining the effectiveness of a treatment protocol of mechanical traction with extension-oriented activities for patients with low back pain and signs of nerve root irritation. The results suggested this approach may be effective, particularly in a more specific sub-group of patients. The aim of this study will be to examine the effectiveness of treatment that includes traction for patients with low back pain and signs of nerve root irritation, and within the pre-defined sub-group. Methods/Design: The study will recruit 120 patients with low back pain and signs of nerve root irritation. Patients will be randomized to receive an extension-oriented treatment approach, with or without the addition of mechanical traction. Randomization will be stratified based on the presence of the pre-defined sub-grouping criteria. All patients will receive 12 physical therapy treatment sessions over 6 weeks. Follow-up assessments will occur after 6 weeks, 6 months, and 1 year. The primary outcome will be disability measured with a modified Oswestry questionnaire. Secondary outcomes will include self-reports of low back and leg pain intensity, quality of life, global rating of improvement, additional healthcare utilization, and work absence. Statistical analysis will be based on intention to treat principles and will use linear mixed model analysis to compare treatment groups, and examine the interaction between treatment and sub-grouping status. Discussion: This trial will provide a methodologically rigorous evaluation of the effectiveness of using traction for patients with low back pain and signs of nerve root irritation, and will examine the validity of a pre-defined sub-grouping hypothesis. The results will provide evidence to inform non-surgical decision-making for these patients. C1 [Fritz, Julie M.; Thackeray, Anne; Brennan, Gerard P.] Rehabil Agcy, Intermt Healthcare, Salt Lake City, UT USA. [Fritz, Julie M.; Thackeray, Anne] Univ Utah, Dept Phys Therapy, Salt Lake City, UT USA. [Childs, John D.] Baylor Univ, USA, Ft Sam Houston, TX USA. RP Fritz, JM (reprint author), Rehabil Agcy, Intermt Healthcare, Salt Lake City, UT USA. EM julie.fritz@hsc.utah.edu OI Thackeray, Anne/0000-0002-5496-7730 FU DJO incorporated, Vista, California, USA FX We acknowledge a potential competing interest in the funding of this study, which is provided by DJO incorporated, Vista, California, USA. DJO is the parent company of Chattanooga, Inc., the manufacturer of the 3D ActiveTrac traction table used in this study. NR 49 TC 9 Z9 10 U1 0 U2 11 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2474 J9 BMC MUSCULOSKEL DIS JI BMC Musculoskelet. Disord. PD APR 30 PY 2010 VL 11 AR 81 DI 10.1186/1471-2474-11-81 PG 10 WC Orthopedics; Rheumatology SC Orthopedics; Rheumatology GA 603RF UT WOS:000278225000002 PM 20433733 ER PT J AU Vo-Dinh, T Dhawan, A Norton, SJ Khoury, CG Wang, HN Misra, V Gerhold, MD AF Vo-Dinh, Tuan Dhawan, Anuj Norton, Stephen J. Khoury, Christopher G. Wang, Hsin-Neng Misra, Veena Gerhold, Michael D. TI Plasmonic Nanoparticles and Nanowires: Design, Fabrication and Application in Sensing SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID ENHANCED-RAMAN-SCATTERING; SINGLE-MOLECULE; METALLIC NANOSTRUCTURES; OPTICAL-PROPERTIES; SILVER ELECTRODE; LINEAR-CHAINS; HOT-SPOTS; SPECTROSCOPY; SERS; DIMERS AB This study involves two aspects of our investigations of plasmonics-active systems: (i) theoretical and simulation studies and (ii) experimental fabrication of plasmonics-active nanostructures. Two types of nanostructures are selected as the model systems for their unique plasmonics properties: (1) nanoparticles and (2) nanowires on substrate. Special focus is devoted to regions where the electromagnetic field is strongly concentrated by the metallic nanostructures or between nanostructures. The theoretical investigations deal with dimers of nanoparticles and nanoshells using a semianalytical method based on a multipole expansion (ME) and the finite-element method (FEM) in order to determine the electromagnetic enhancement, especially at the interface areas of two adjacent nanoparticles. The experimental study involves the design of plasmonics-active nanowire arrays on substrates that can provide efficient electromagnetic enhancement in regions around and between the nanostructures. Fabrication of these nanowire structures over large chip-scale areas (from a few millimeters to a few centimeters) as well as FDTD simulations to estimate the EM fields between the nanowires are described. The application of these nanowire chips using surface-enhanced Raman scattering for detection of chemicals and labeled DNA molecules is described to illustrate the potential of the plasmonics chips for sensing. C1 [Vo-Dinh, Tuan; Dhawan, Anuj; Norton, Stephen J.; Khoury, Christopher G.; Wang, Hsin-Neng] Duke Univ, Fitzpatrick Inst Photon, Dept Biomed Engn, Durham, NC 27708 USA. [Vo-Dinh, Tuan; Dhawan, Anuj; Norton, Stephen J.; Khoury, Christopher G.; Wang, Hsin-Neng] Duke Univ, Dept Chem, Durham, NC 27708 USA. [Misra, Veena] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27606 USA. [Gerhold, Michael D.] USA, Div Elect, Res Off, Durham, NC 27703 USA. RP Vo-Dinh, T (reprint author), Duke Univ, Fitzpatrick Inst Photon, Dept Biomed Engn, Durham, NC 27708 USA. EM tuan.vodinh@duke.edu RI Wang, Hsin-Neng/D-9631-2013 FU National Institutes of Health [R01 EB006201, R01 ES014774-01A1]; Army Research Office [W911NF-04-D-0001-0008] FX This work was sponsored by the National Institutes of Health (Grants R01 EB006201 and R01 ES014774-01A1) and Army Research Office (Grant No. W911NF-04-D-0001-0008). NR 80 TC 50 Z9 50 U1 3 U2 47 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD APR 29 PY 2010 VL 114 IS 16 BP 7480 EP 7488 DI 10.1021/jp911355q PG 9 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 586FP UT WOS:000276889300039 PM 24839505 ER PT J AU Berg, MJ Hill, SC Videen, G Gurton, KP AF Berg, Matthew J. Hill, Steven C. Videen, Gorden Gurton, Kristan P. TI Spatial filtering technique to image and measure two-dimensional near-forward scattering from single particles SO OPTICS EXPRESS LA English DT Article ID LIGHT-SCATTERING; SPHERES AB This work describes the design and use of an optical apparatus to measure the far-field elastic light-scattering pattern for a single particle over two angular-dimensions. A spatial filter composed of a mirror with a small through-hole is used to enable collection of the pattern uncommonly close to the forward direction; to within tenths of a degree. Minor modifications of the design allow for the simultaneous measurement of a particle's image along with its two-dimensional scattering pattern. Example measurements are presented involving single micrometer-sized glass spherical particles confined in an electrodynamic trap and a dilute suspension of polystyrene latex particles in water. A small forward-angle technique, called Guinier analysis, is used to determine a particle-size estimate directly from the measured pattern without a priori knowledge of the particle refractive index. Comparison of these size estimates to those obtained by fitting the measurements to Mie theory reveals relative errors as low as 2%. C1 [Berg, Matthew J.; Hill, Steven C.; Videen, Gorden; Gurton, Kristan P.] USA, Res Lab, RDRL CIE S, Adelphi, MD 20783 USA. RP Berg, MJ (reprint author), USA, Res Lab, RDRL CIE S, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM mberg81@gmail.com FU National Research Council; United States Defense Threat Reduction Agency [DAAD17-03-0070] FX This work was supported by a National Research Council Postdoctoral Fellowship, funded by the United States Defense Threat Reduction Agency, contract no. DAAD17-03-0070. The authors are thankful for assistance provided by Melvin Felton, Chatt Williamson, and Drs. David Ligon, Leonid Beresnev, Chris Sorensen, and comments provided by two anonymous reviewers. NR 15 TC 9 Z9 10 U1 3 U2 12 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD APR 26 PY 2010 VL 18 IS 9 BP 9486 EP 9495 DI 10.1364/OE.18.009486 PG 10 WC Optics SC Optics GA 588OR UT WOS:000277082200078 PM 20588794 ER PT J AU Cole, B Goldberg, L King, V Leach, J AF Cole, Brian Goldberg, Lew King, Vernon Leach, Jeff TI Influence of UV illumination on the cold temperature operation of a LiNbO3 Q-switched Nd:YAG laser SO OPTICS EXPRESS LA English DT Article ID LITHIUM-NIOBATE CRYSTAL; OPTICAL DAMAGE AB UV illumination of a lithium niobate Q-switch was demonstrated as an effective means to eliminate a loss in hold-off and associated prelasing that occurs under cold temperature operation of Q-switched lasers. This degradation occurs due to the pyroelectric effect, where an accumulation of charge on crystal faces results in a reduction in the Q-switch hold-off and a spatially variable loss of the Q-switch in its high-transmission state, both resulting in lowering of the maximum Q-switched pulse energy. With UV illumination, the resulting creation of photo-generated carriers was shown to be effective in eliminating both of these effects. A Q-switched Nd:YAG laser utilizing UV-illuminated LiNbO3 was shown to operate under cold temperatures without prelasing or spatially variable loss. (C) 2010 Optical Society of America C1 [Cole, Brian; Goldberg, Lew; King, Vernon; Leach, Jeff] USA, RDECOM CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Cole, B (reprint author), USA, RDECOM CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. EM info@nvl.army.mil NR 14 TC 4 Z9 4 U1 0 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD APR 26 PY 2010 VL 18 IS 9 BP 9622 EP 9627 DI 10.1364/OE.18.009622 PG 6 WC Optics SC Optics GA 588OR UT WOS:000277082200093 PM 20588809 ER PT J AU Crum-Cianflone, NF Roediger, M Eberly, LE Vyas, K Landrum, ML Ganesan, A Weintrob, AC Barthel, RV Agan, BK AF Crum-Cianflone, Nancy F. Roediger, Mollie Eberly, Lynn E. Vyas, Kurt Landrum, Mike L. Ganesan, Anuradha Weintrob, Amy C. Barthel, Robert Vincent Agan, Brian K. CA Infect Dis Clinical Res Program HI TI Obesity among HIV-infected persons: impact of weight on CD4 cell count SO AIDS LA English DT Article ID C-REACTIVE PROTEIN; BODY-MASS INDEX; DISEASE PROGRESSION; SURVIVAL; OVERWEIGHT; ADULTS; AIDS; PREDICTOR; COHORT; ALPHA AB To assess the effect of obesity on CD4 cell counts, we estimated the association of time-updated BMI categories with CD4 changes among 1001 documented HIV seroconverters. During the pre-highly active antiretroviral therapy (HAART) era, a higher BMI was associated with less reduction in CD4 cell counts over time. However during the HAART era, obese versus normal weight patients had smaller increases in CD4 cell counts (+69 versus +116 cells, P=0.01). Lower CD4 cell counts may now be another adverse consequence of obesity. C1 [Crum-Cianflone, Nancy F.; Roediger, Mollie; Eberly, Lynn E.; Vyas, Kurt; Landrum, Mike L.; Ganesan, Anuradha; Weintrob, Amy C.; Barthel, Robert Vincent; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Crum-Cianflone, Nancy F.; Vyas, Kurt] Naval Med Ctr San Diego, Infect Dis Clin, San Diego, CA USA. [Roediger, Mollie; Eberly, Lynn E.] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Landrum, Mike L.] San Antonio Mil Med Ctr, Infect Dis Clin, San Antonio, TX USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Infect Dis Clin, Bethesda, MD USA. [Weintrob, Amy C.] Walter Reed Army Med Ctr, Infect Dis Clin, Washington, DC 20307 USA. [Barthel, Robert Vincent] Naval Med Ctr Portsmouth, Infect Dis Clin, Portsmouth, VA USA. RP Crum-Cianflone, NF (reprint author), Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. OI Agan, Brian/0000-0002-5114-1669; Eberly, Lynn/0000-0003-4763-330X FU Infectious Disease Clinical Research Program (IDCRP) [IDCRP-RV168F]; Department of Defense (DoD); National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [Y1-AI-5072]; N.F.C.C.; B.K.A FX The present study (IDCRP-RV168F) was supported by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072.; Obtaining funding from N.F.C.C. and B.K.A. NR 20 TC 25 Z9 25 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 J9 AIDS JI Aids PD APR 24 PY 2010 VL 24 IS 7 BP 1069 EP 1072 DI 10.1097/QAD.0b013e328337fe01 PG 4 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 582AN UT WOS:000276567500021 PM 20216300 ER PT J AU Mukhopadhyay, S Gowtham, S Scheicher, RH Pandey, R Karna, SP AF Mukhopadhyay, Saikat Gowtham, S. Scheicher, Ralph H. Pandey, Ravindra Karna, Shashi P. TI Theoretical study of physisorption of nucleobases on boron nitride nanotubes: a new class of hybrid nano-biomaterials SO NANOTECHNOLOGY LA English DT Article ID SINGLE-WALLED CARBON; MOLECULAR-DYNAMICS; DNA; FUNCTIONALIZATION; EXCHANGE; COVALENT; BINDING; COMPLEX AB We investigate the adsorption of the nucleic acid bases-adenine (A), guanine (G), cytosine (C), thymine (T) and uracil (U)-on the outer wall of a high curvature semiconducting single-walled boron nitride nanotube (BNNT) by first-principles density functional theory calculations. The calculated binding energy shows the order: G > A approximate to C approximate to T approximate to U, implying that the interaction strength of the high curvature BNNT with the nucleobases, G being an exception, is nearly the same. A higher binding energy for the G-BNNT conjugate appears to result from hybridization of the molecular orbitals of G and the BNNT. A smaller energy gap predicted for the G-BNNT conjugate relative to that of the pristine BNNT may be useful in the application of this class of biofunctional materials to the design of next-generation sensing devices. C1 [Mukhopadhyay, Saikat; Gowtham, S.; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [Scheicher, Ralph H.] Uppsala Univ, Dept Phys & Mat Sci, SE-75121 Uppsala, Sweden. [Karna, Shashi P.] USA, Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA. RP Pandey, R (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. EM pandey@mtu.edu RI Scheicher, Ralph/G-1740-2012; Mukhopadhyay, Saikat/B-4402-2011 FU Army Research Office [W911NF-09-1-0221]; Wenner-Gren Foundations in Stockholm FX Helpful discussions with Haiying He are gratefully acknowledged. The work at Michigan Technological University was performed under support by the Army Research Office through contract number W911NF-09-1-0221. RHS acknowledges financial support from Wenner-Gren Foundations in Stockholm. NR 37 TC 44 Z9 44 U1 1 U2 27 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0957-4484 EI 1361-6528 J9 NANOTECHNOLOGY JI Nanotechnology PD APR 23 PY 2010 VL 21 IS 16 AR 165703 DI 10.1088/0957-4484/21/16/165703 PG 6 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA 575YY UT WOS:000276111200022 PM 20351402 ER PT J AU Jindal, RM Ricordi, C Shriver, CD AF Jindal, Rahul M. Ricordi, Camillo Shriver, Craig D. TI Autologous Pancreatic Islet Transplantation for Severe Trauma SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter C1 [Jindal, Rahul M.; Shriver, Craig D.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Ricordi, Camillo] Univ Miami, Diabet Res Inst, Miami, FL USA. RP Jindal, RM (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. EM jindalr@msn.com NR 3 TC 19 Z9 19 U1 1 U2 2 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD APR 22 PY 2010 VL 362 IS 16 BP 1550 EP 1550 DI 10.1056/NEJMc0912392 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 586GP UT WOS:000276894700033 PM 20410526 ER PT J AU DeVine, J Chutkan, N Norvell, DC Dettori, JR AF DeVine, John Chutkan, Norman Norvell, Daniel C. Dettori, Joseph R. TI Avoiding Wrong Site Surgery A Systematic Review SO SPINE LA English DT Review DE wrong site; wrong level; wrong patient; wrong side ID LEVEL SURGERY; DISKECTOMY AB Study Design. Systematic review. Objective. To report the incidence and causes of wrong site surgery and determine what preoperative measures are effective in preventing wrong site surgery. Summary of Background Data. From 1995 to 2005, the Joint Commission (JC) sentinel event statistics database ranked wrong site surgery as the second most frequently reported event with 455 of 3548 sentinel events (12.8%). Although the event seems to be rare, the incidence of these complications has been difficult to measure and quantify. The implications for wrong site surgery go beyond the effects to the patient. Such an event has profound medical, legal, social, and emotional implications. Methods. A systematic review of the English language literature was undertaken for articles published between 1990 and December 2008. Electronic databases and reference lists of key articles were searched to identify the articles defining wrong site surgery and reporting wrong site events. Two independent reviewers assessed the level of evidence quality using the Grading of Recommendations Assessment, Development, and Evaluation criteria and disagreements were resolved by consensus. Results. The estimated rate of wrong site surgery varies widely ranging from 0.09 to 4.5 per 10,000 surgeries performed. There is no literature to substantiate the effectiveness of the current JC Universal Protocol in decreasing the rate of wrong site, wrong level surgery. Conclusion. Wrong site surgery may be preventable. We suggest that the North American Spine Society and JC checklists are insufficient on their own to minimize this complication. Therefore, in addition to these protocols, we recommend intraoperative imaging after exposure- and marking of a fixed anatomic structure. This imaging should be compared with routine preoperative studies to determine the correct site for spine surgery. C1 [DeVine, John] Eisenhower Army Med Ctr, Orthoped Serv, Dept Surg, Ft Gordon, GA 30809 USA. [Chutkan, Norman] Med Coll Georgia, Dept Orthopaed Surg, Augusta, GA 30912 USA. [Norvell, Daniel C.; Dettori, Joseph R.] Spectrum Res Inc, Tacoma, WA USA. RP DeVine, J (reprint author), Eisenhower Army Med Ctr, Orthoped Serv, Dept Surg, 300 E Hosp Rd, Ft Gordon, GA 30809 USA. EM john-devine@comcast.net FU AOSpine North America FX Supported by AOSpine North America. Analytic support for this work was provided by Spectrum Research, Inc. with funding from AOSpine North America. No benefits in any form have been or will be received from a commercial party related directly or indirectly to the subject of this manuscript. NR 26 TC 55 Z9 55 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD APR 20 PY 2010 VL 35 IS 9 SU S BP S28 EP S36 DI 10.1097/BRS.0b013e3181d833ac PG 9 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 590KI UT WOS:000277224100004 PM 20407349 ER PT J AU Martin, SS Bakken, RR Lind, CM Garcia, P Jenkins, E Glass, PJ Parker, MD Hart, MK Fine, DL AF Martin, Shannon S. Bakken, Russell R. Lind, Cathleen M. Garcia, Patricia Jenkins, Erin Glass, Pamela J. Parker, Michael D. Hart, Mary Kate Fine, Donald L. TI Evaluation of formalin inactivated V3526 virus with adjuvant as a next generation vaccine candidate for Venezuelan equine encephalitis virus SO VACCINE LA English DT Article DE Venezuelan equine encephalitis virus (VEEV); Formalin-inactivated vaccine; Intramuscular vaccination ID ENCEPHALOMYELITIS VIRUS; AEROSOL CHALLENGE; NEUTRALIZING ANTIBODIES; ATTENUATED TC-83; VEE VIRUS; IN-VITRO; C-CLASS; PROTECTION; INFECTION; MICE AB V3526, a genetically modified strain of Venezuelan equine encephalitis virus (VEEV), was formalin inactivated for evaluation as a next generation vaccine candidate for VEEV. In this study, we tested formalin-inactivated V3526 (fV3526) with and without adjuvant for immunogenicity and efficacy in BALB/c mice and results were compared to the existing inactivated VEEV vaccine, C84. Mice were vaccinated intramuscularly (IM) or subcutaneously (SC) with fV3526 formulations and challenged with VEEV IAB Trinidad donkey (VEEV TrD) strain by SC or aerosol exposure. Efficacy following SC or aerosol challenge was not significantly different between the fV3526 formulations or compared to C84 despite C84 being administered in more doses and higher concentration of viral protein per dose. These data support further evaluation of fV3526 formulations as a next generation VEEV vaccine. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Martin, Shannon S.; Jenkins, Erin; Hart, Mary Kate; Fine, Donald L.] DynPort Vaccine Co LLC DVC, Frederick, MD 21702 USA. [Bakken, Russell R.; Lind, Cathleen M.; Garcia, Patricia; Glass, Pamela J.; Parker, Michael D.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. RP Martin, SS (reprint author), DynPort Vaccine Co LLC DVC, 64 Thomas Johnson Dr, Frederick, MD 21702 USA. EM smartin40@csc.com RI Glass, Pamela/G-1170-2011 FU National Institute of Allergy and Infectious Diseases [1UC1AI062538-01]; Joint Science and Technology Office-Chemical, Biological Defense [Plan1.1C0041_09_RD_B] FX This study was funded by the National Institute of Allergy and Infectious Diseases (1UC1AI062538-01) and Joint Science and Technology Office-Chemical, Biological Defense ((Plan1.1C0041_09_RD_B). We thank the aerobiology staff at USAM-RIID for their contributions to the aerosol challenge components of this study. NR 52 TC 10 Z9 10 U1 2 U2 9 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD APR 19 PY 2010 VL 28 IS 18 BP 3143 EP 3151 DI 10.1016/j.vaccine.2010.02.056 PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 588JA UT WOS:000277064500011 PM 20193792 ER PT J AU Banks, HD AF Banks, Harold D. TI Torquoselectivity Studies in the Generation of Azomethine Ylides from Substituted Aziridines SO JOURNAL OF ORGANIC CHEMISTRY LA English DT Article ID RING-OPENING REACTIONS; CONROTATORY ELECTROCYCLIC REACTIONS; GEMINAL BOND PARTICIPATION; CLICK CHEMISTRY; NAZAROV REACTION; ASYMMETRIC-SYNTHESIS; 3+2 CYCLOADDITION; SOLVATION MODELS; SILYL GROUPS; CYCLOBUTENES AB Aziridines are useful precursors to the azomethine ylide family of 1,3-dipoles whose cycloaddition chemistry has been extensively exploited in the synthesis of heterocyclic targets. The torquoselectivity of aziridines that lack a plane of symmetry was investigated as an essential component of the calculation of the overall relative reaction rates and in prediction of the stereochemistry of the 2,3-trans compounds in 1,3-dipolar cycloaddition chemistry. It has been found at the MP2(Full)/6-311++G(d,p)//MP2(Full)/6-31+G(d) level that outward rotation is preferred for electronegative or anionic substituents while electropositive and cationic substituents favor inward rotation. After consideration of frontier molecular orbital theory, inductive, resonance, and electrostatic effects, an explanation of the preferred direction of rotation during ring cleavage that is based on substituent electron-withdrawing ability by means of a polar effect is presented. C1 USA, Edgewood Chem Biol Ctr APG, Aberdeen Proving Ground, MD 21010 USA. RP Banks, HD (reprint author), USA, Edgewood Chem Biol Ctr APG, Aberdeen Proving Ground, MD 21010 USA. EM harold.banks@us.army.mil NR 135 TC 13 Z9 13 U1 2 U2 17 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-3263 J9 J ORG CHEM JI J. Org. Chem. PD APR 16 PY 2010 VL 75 IS 8 BP 2510 EP 2517 DI 10.1021/jo902600y PG 8 WC Chemistry, Organic SC Chemistry GA 581WQ UT WOS:000276556600010 PM 20329779 ER PT J AU Ghosh, S Ingerman, LA Frye, AG Lee, SJ Gagne, MR Waters, ML AF Ghosh, Soumyadip Ingerman, Lindsey A. Frye, Aaron G. Lee, Stephen J. Gagne, Michel R. Waters, Marcey L. TI Dynamic Cyclic Thiodepsipeptide Libraries From Thiol-Thioester Exchange SO ORGANIC LETTERS LA English DT Article ID HISTONE DEACETYLASE INHIBITORS; COMBINATORIAL LIBRARIES; PEPTIDES; CHEMISTRY; LIGATION AB Thiol thioester exchange was found to readily generate libraries of cyclic thiodepsipeptides under thermodynamic control, which will enable their use in a variety of dynamic combinatorial chemistry assays. The kinetic determinants of macrocycle formation and the role of amino acid structure on the reaction dynamics are discussed. C1 [Ghosh, Soumyadip; Ingerman, Lindsey A.; Frye, Aaron G.; Gagne, Michel R.; Waters, Marcey L.] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA. [Lee, Stephen J.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Gagne, MR (reprint author), Univ N Carolina, Dept Chem, CB 3290, Chapel Hill, NC 27599 USA. EM mgagne@unc.edu; mlwaters@unc.edu FU Defense Threat Reduction Agency [DTRA, W911NF-06-1-0169] FX We thank the Defense Threat Reduction Agency (DTRA, W911NF-06-1-0169) for support. NR 21 TC 15 Z9 15 U1 0 U2 19 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1523-7060 J9 ORG LETT JI Org. Lett. PD APR 16 PY 2010 VL 12 IS 8 BP 1860 EP 1863 DI 10.1021/ol1004752 PG 4 WC Chemistry, Organic SC Chemistry GA 581YT UT WOS:000276562600054 PM 20329734 ER PT J AU Srikiatkhachorn, A Gibbons, RV Green, S Libraty, DH Thomas, SJ Endy, TP Vaughn, DW Nisalak, A Ennis, FA Rothman, AL Nimmannitaya, S Kalayanarooj, S AF Srikiatkhachorn, Anon Gibbons, Robert V. Green, Sharone Libraty, Daniel H. Thomas, Stephen J. Endy, Timothy P. Vaughn, David W. Nisalak, Ananda Ennis, Francis A. Rothman, Alan L. Nimmannitaya, Suchitra Kalayanarooj, Siripen TI Dengue Hemorrhagic Fever: The Sensitivity and Specificity of the World Health Organization Definition for Identification of Severe Cases of Dengue in Thailand, 1994-2005 SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID DISEASE SEVERITY; CLASSIFICATION-SYSTEM; INFECTION; CHILDREN; DIAGNOSIS; NICARAGUA; THERAPY; VIRUSES; ILLNESS AB Background. Dengue virus infection causes a spectrum of clinical manifestations, usually classified according to the World Health Organization (WHO) guidelines into dengue fever (DF) and dengue hemorrhagic fever (DHF). The ability of these guidelines to categorize severe dengue illness has recently been questioned. Methods. We evaluated dengue case definitions in a prospective study at a pediatric hospital in Bangkok, Thailand, during 1994-2005. One thousand thirteen children were enrolled within the first 3 days after onset of fever and observed with standardized data collection. Cases were classified on the basis of application of the strict WHO criteria. All dengue virus infections were laboratory confirmed. We retrospectively grouped patients on the basis of whether they received significant intervention based on fluid replacement and/or requirements for blood transfusion. Results. Eighty-five (58%) of 150 persons with DHF, 40 (15%) of 264 with DF, and 73 (12%) of 599 with other febrile illnesses (OFIs) received significant intervention. Sixty-eight percent of dengue cases requiring intervention met strict WHO criteria for DHF. In contrast, only 1% of OFI cases met WHO criteria for DHF. Plasma leakage and thrombocytopenia were the 2 components contributing to the specificity of the WHO case definition and identified dengue cases that required intervention. Hemorrhagic tendency did not reliably differentiate DF and DHF. In DF cases, thrombocytopenia and bleeding were associated with severity. Conclusions. Dengue illness is heterogeneous in severity, and severe clinical features occurred in patients whose cases were not characterized as DHF. The WHO case definition of DHF demonstrated sensitivity of 62% and specificity of 92% for identification of dengue illness requiring intervention, without the need for laboratory confirmation of dengue virus infection, in an area of endemicity. C1 [Srikiatkhachorn, Anon] Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA 01655 USA. [Endy, Timothy P.] SUNY Upstate Med Univ, Syracuse, NY USA. [Vaughn, David W.] USA, Mil Infect Dis Res Program, Med Res & Mat Command, Ft Detrick, MD USA. [Gibbons, Robert V.; Thomas, Stephen J.; Nisalak, Ananda] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Nimmannitaya, Suchitra; Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. RP Srikiatkhachorn, A (reprint author), Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, 55 Lake Ave N,Rm S6-862, Worcester, MA 01655 USA. EM anon.srikiatkhachorn@umassmed.edu FU National Institutes of Health [NIH-P01AI34533]; Military Infectious Disease Research Program FX The National Institutes of Health (NIH-P01AI34533) and the Military Infectious Disease Research Program. The opinions or assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the view of the US Government. NR 30 TC 50 Z9 50 U1 0 U2 5 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD APR 15 PY 2010 VL 50 IS 8 BP 1135 EP 1143 DI 10.1086/651268 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 570BF UT WOS:000275645900008 PM 20205587 ER PT J AU Van Horn, GT Goodrich, A Winslow, DL AF Van Horn, Gerald T. Goodrich, Aryn Winslow, Dean L. TI Gross Hematuria in a Young Iraqi Man - Diagnosis: infection due to Schistosoma haematobium SO CLINICAL INFECTIOUS DISEASES LA English DT Editorial Material ID GRANULOMA C1 [Winslow, Dean L.] Stanford Univ, Sch Med, Div Infect Dis & Geog Med, Stanford, CA 94305 USA. [Van Horn, Gerald T.] Walter Reed Army Med Ctr, Dept Pathol & Area Lab Serv, Washington, DC 20307 USA. [Goodrich, Aryn] 115th Combat Support Hosp, Ft Polk, LA USA. [Winslow, Dean L.] Santa Clara Valley Med Ctr, San Jose, CA 95128 USA. RP Winslow, DL (reprint author), Stanford Univ, Sch Med, Div Infect Dis & Geog Med, 300 Pasteur Dr,Rm S101D, Stanford, CA 94305 USA. EM dwinslow@stanford.edu NR 4 TC 0 Z9 0 U1 1 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD APR 15 PY 2010 VL 50 IS 8 BP 1144 EP + DI 10.1086/651270 PG 3 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 570BF UT WOS:000275645900017 PM 20233043 ER PT J AU Halstead, SB Thomas, SJ AF Halstead, Scott B. Thomas, Stephen J. TI Japanese Encephalitis: New Options for Active Immunization SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID SA 14-14-2 VACCINE; NEUTRALIZING ANTIBODY-RESPONSE; NILE-VIRUS-INFECTIONS; VERO CELLS; ATTENUATED VACCINE; CONTROLLED PHASE-3; ENVELOPE GENES; PYRETHROID INSECTICIDE; FLAVIVIRUS INFECTIONS; SA-14-14-2 VACCINE AB Japanese encephalitis (JE) is a mosquito-borne flavivirus infection responsible for significant morbidity and mortality across Asia. Indigenous populations and those who undertake short-and long-term travel to endemic regions are at risk of infection and development of neuroinvasive disease. Effective mouse brain-derived vaccines have been available in select countries, including the United States, for decades. Limited access in Asia and safety concerns with regard to mouse brain products prompted the Chinese to develop a live, attenuated virus vaccine (SA14-14-2; Chengdu Institute of Biological Products), which has proven to be safe and efficacious following administration of >300 million doses. Recently, the portfolio of JE vaccines increased again with licensure in the United States, Europe, and Australia of a purified, inactivated virus JE vaccine (IC51; Intercell AG) and filing for licensure in Thailand and Australia of a Yellow fever-JE chimeric vaccine (ChimeriVax-JE; Sanofi Pasteur). JE is a vaccine-preventable disease with numerous options now available for active immunization. Aggressive and responsible vaccination programs should greatly diminish the burden of disease. C1 [Halstead, Scott B.] Pediat Dengue Vaccine Initiat, Res Program, Rockville, MD 20852 USA. [Thomas, Stephen J.] US Army Med Component Armed Forces Res Inst Med S, Dept Virol, Bangkok, Thailand. RP Halstead, SB (reprint author), Pediat Dengue Vaccine Initiat, Res Program, 5824 Edson Lane, Rockville, MD 20852 USA. EM halsteads@erols.com NR 84 TC 47 Z9 54 U1 0 U2 4 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD APR 15 PY 2010 VL 50 IS 8 BP 1155 EP 1164 DI 10.1086/651271 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 570BF UT WOS:000275645900011 PM 20218889 ER PT J AU Okulicz, JF Grandits, GA Weintrob, AC Landrum, ML Ganesan, A Crum-Cianflone, NF Agan, BK Marconi, VC AF Okulicz, Jason F. Grandits, Greg A. Weintrob, Amy C. Landrum, Michael L. Ganesan, Anuradha Crum-Cianflone, Nancy F. Agan, Brian K. Marconi, Vincent C. TI CD4 T Cell Count Reconstitution in HIV Controllers after Highly Active Antiretroviral Therapy SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; LOW-LEVEL VIREMIA; RNA LEVELS; INDIVIDUALS; INFECTION; RESPONSES; ABSENCE AB Sixty-two human immunodeficiency virus (HIV) controllers (6 elite and 56 viremic controllers) in the US Military Department of Defense HIV Natural History Study cohort initiated highly active antiretroviral therapy (HAART) and achieved statistically significant mean CD4 cell count increases, although the gains were lower than those in treated noncontrollers. HIV controllers experienced CD4 cell count reconstitution with HAART regardless of pretherapy viral load, including patients with undetectable viral loads at HAART initiation. C1 [Okulicz, Jason F.; Grandits, Greg A.; Weintrob, Amy C.; Landrum, Michael L.; Ganesan, Anuradha; Crum-Cianflone, Nancy F.; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Div Infect Dis, Bethesda, MD USA. [Okulicz, Jason F.; Landrum, Michael L.] San Antonio Mil Med Ctr, Infect Dis Serv, San Antonio, TX USA. [Grandits, Greg A.] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Weintrob, Amy C.] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. [Crum-Cianflone, Nancy F.] Naval Med Ctr San Diego, Infect Dis Clin, San Diego, CA USA. [Marconi, Vincent C.] Emory Univ, Sch Med, Atlanta, GA USA. RP Okulicz, JF (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Jason.okulicz@amedd.army.mil RI Marconi, Vincent/N-3210-2014; OI Marconi, Vincent/0000-0001-8409-4689; Agan, Brian/0000-0002-5114-1669 FU Uniformed Services University of the Health Sciences [IDCRP-000-05]; National Institute of Allergy and Infectious Diseases, National Institutes of Health [Y1-AI-5072] FX Support for this work (IDCRP-000-05) was provided by the Infectious Disease Clinical Research Program, a Department of Defense program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole or in part with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, under interagency agreement Y1-AI-5072. NR 13 TC 19 Z9 19 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD APR 15 PY 2010 VL 50 IS 8 BP 1187 EP 1191 DI 10.1086/651421 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 570BF UT WOS:000275645900015 PM 20218878 ER PT J AU Little, JW Olver, KA AF Little, J. W. Olver, K. A. TI Stark shifts in mid-infrared type II quantum well transitions SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID OPTIC EFFECT DEVICE; INFRARED PHOTODIODES; MU-M; DETECTORS; SWITCH AB We have studied electric field induced (Stark) shifts in mid-infrared (IR) transitions that occur in type II AlSb/InAs/GaSb quantum wells. Because of the spatial separation of the electron and hole wave functions in the type II system, the potential drop between the layers dominates the shift in the real-space-indirect transition energies when an external electric field is applied. This can result in either a redshift or a blueshift, depending on the ordering of the quantum well layers within the intrinsic region of a p-i-n diode. The case in which a reverse bias on the diode yields a blueshift in the transition energy is of particular interest for IR electro-optic device applications. The modulator section of an integrated source/waveguide modulator would strongly absorb at zero bias and could be biased into transparency, and bistable optical switches could be made more efficient than with redshifting devices. We have used low temperature current-voltage, capacitance-voltage, and photocurrent measurements to characterize a type II quantum well structure that exhibits a blueshift in the lowest energy transitions that is roughly linear with applied bias and is comparable to the potential drop across the structure. (C) 2010 American Institute of Physics. [doi:10.1063/1.3383040] C1 [Little, J. W.; Olver, K. A.] USA, Res Lab, Adelphi, MD 20783 USA. RP Little, JW (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM jlittle@arl.army.mil NR 16 TC 2 Z9 2 U1 0 U2 4 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD APR 15 PY 2010 VL 107 IS 8 AR 083108 DI 10.1063/1.3383040 PG 4 WC Physics, Applied SC Physics GA 591LX UT WOS:000277303200009 ER PT J AU Cheezum, MK Lettieri, CJ AF Cheezum, Michael K. Lettieri, Christopher J. TI Obstructive Sleep Apnea Presenting as Pseudopheochromocytoma SO JOURNAL OF CLINICAL SLEEP MEDICINE LA English DT Article DE Obstructive sleep apnea; pheochromocytoma; pseudopheochromocytoma; endocrinopathy ID POSITIVE AIRWAY PRESSURE; HYPERTENSION AB A 39-year-old man with a history of poorly controlled hypertension presented with a 2-year history of fatigue, daytime somnolence, and intermittent episodes of diaphoresis and palpitations. Episodes were self-limiting, lasting approximately 5-10 minutes and occurred several times per month, most notably at night Laboratory evaluation was significant for elevated 24-h urinary catecholamine levels, suggestive of pheochromocytoma However, thorough imaging failed to identify a catecholamine-secreting tumor Subsequent polysomnography revealed severe obstructive sleep apnea, with an apnea-hypopnea index of 112 events/h. After one month of continuous positive airway pressure therapy, the patient experienced resolution of his presenting symptoms, improved blood pressure control and normalization of his urinary catecholamine levels. This case highlights sleep disordered breathing as a potentially reversible cause of pseudopheochromocytoma C1 [Cheezum, Michael K.; Lettieri, Christopher J.] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. [Lettieri, Christopher J.] Walter Reed Army Med Ctr, Dept Pulm Crit Care & Sleep Med, Washington, DC 20307 USA. RP Lettieri, CJ (reprint author), Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. NR 6 TC 3 Z9 6 U1 0 U2 1 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 1550-9389 J9 J CLIN SLEEP MED JI J. Clin. Sleep Med. PD APR 15 PY 2010 VL 6 IS 2 BP 190 EP 191 PG 2 WC Clinical Neurology SC Neurosciences & Neurology GA 584XV UT WOS:000276788500014 PM 20411698 ER PT J AU Carter, KA Lettieri, CJ Pena, JM AF Carter, Kevin A. Lettieri, Christopher J. Pena, Jennifer M. TI An Unusual Cause of Insomnia Following IED-Induced Traumatic Brain Injury SO JOURNAL OF CLINICAL SLEEP MEDICINE LA English DT Editorial Material C1 [Pena, Jennifer M.] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. [Lettieri, Christopher J.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. NR 5 TC 3 Z9 3 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 1550-9389 J9 J CLIN SLEEP MED JI J. Clin. Sleep Med. PD APR 15 PY 2010 VL 6 IS 2 BP 205 EP 206 PG 2 WC Clinical Neurology SC Neurosciences & Neurology GA 584XV UT WOS:000276788500017 PM 20411701 ER PT J AU Pelak, K Goldstein, DB Walley, NM Fellay, J Ge, D Shianna, KV Gumbs, C Gao, X Maia, JM Cronin, KD Hussain, SK Carrington, M Michael, NL Weintrob, AC AF Pelak, Kimberly Goldstein, David B. Walley, Nicole M. Fellay, Jacques Ge, Dongliang Shianna, Kevin V. Gumbs, Curtis Gao, Xiaojiang Maia, Jessica M. Cronin, Kenneth D. Hussain, Shehnaz K. Carrington, Mary Michael, Nelson L. Weintrob, Amy C. CA Natl Inst Allergy Infect Dis TI Host Determinants of HIV-1 Control in African Americans SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; WHOLE-GENOME ASSOCIATION; LINKAGE DISEQUILIBRIUM; VIRAL LOAD; HLA; SUSCEPTIBILITY; INFECTION; GENETICS; MODELS; SET AB We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the strongest associations. We use a subset of patients to demonstrate that this SNP reflects the effect of the HLA-B*5703 allele, which shows a genome-wide statistically significant association with viral load set point (P = 5.6 x 10(-10)). These analyses therefore confirm a member of the HLA-B*57 group of alleles as the most important common variant that influences viral load variation in African Americans, which is consistent with what has been observed for individuals of European ancestry, among whom the most important common variant is HLA-B*5701. C1 [Pelak, Kimberly; Goldstein, David B.; Walley, Nicole M.; Fellay, Jacques; Ge, Dongliang; Shianna, Kevin V.; Gumbs, Curtis; Maia, Jessica M.; Cronin, Kenneth D.] Duke Univ, Sch Med, Ctr Human Genome Variat, Durham, NC USA. [Gao, Xiaojiang; Carrington, Mary] NCI, Canc & Inflammat Program, Expt Immunol Lab, SAIC Frederick, Frederick, MD 21701 USA. [Michael, Nelson L.] Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD USA. [Weintrob, Amy C.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Hussain, Shehnaz K.] Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA USA. RP Weintrob, AC (reprint author), Walter Reed Army Med Ctr, Bldg 2,Ward 63,Room 6312, Washington, DC 20307 USA. EM amy.weintrob@us.army.mil RI Fellay, Jacques/A-6681-2009; Marconi, Vincent/N-3210-2014 OI Fellay, Jacques/0000-0002-8240-939X; Marconi, Vincent/0000-0001-8409-4689 FU National Institute of Allergy and Infectious Diseases [NIAID], National Institutes of Health [NIH] [Y1-AI5072, 5 T32 GM007754-29, AI067854]; National Cancer Institute (NCI), NIH [HHSN261200800001E]; National Heart, Lung, and Blood Institute [UO1-AI-35042, 5-M01-RR-00052, UO1-AI-35043, UO1-AI-37984, UO1-AI-35039, UO1-AI-35040, UO1-AI-37613, UO1-AI-35041] FX Financial support: Infectious Disease Clinical Research Program (Department of Defense program executed through the Uniformed Services University of the Health Sciences and funded by the National Institute of Allergy and Infectious Diseases [NIAID], National Institutes of Health [NIH], under interagency agreement Y1-AI5072); NIH (genetics training grant 5 T32 GM007754-29 to K. P.); NIAID Center for HIV/AIDS Vaccine Immunology (grant AI067854); National Cancer Institute (NCI), NIH (contract HHSN261200800001E); Center for Cancer Research, NCI, NIH. The Multicenter AIDS Cohort Study is funded by NIAID with supplemental funding from NCI and the National Heart, Lung, and Blood Institute (grants UO1-AI-35042, 5-M01-RR-00052 [GCRC], UO1-AI-35043, UO1-AI-37984, UO1-AI-35039, UO1-AI-35040, UO1-AI-37613, and UO1-AI-35041). NR 19 TC 85 Z9 87 U1 0 U2 7 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD APR 15 PY 2010 VL 201 IS 8 BP 1141 EP 1149 DI 10.1086/651382 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 568AJ UT WOS:000275493400006 PM 20205591 ER PT J AU Sorescu, DC Rice, BM AF Sorescu, Dan C. Rice, Betsy M. TI Theoretical Predictions of Energetic Molecular Crystals at Ambient and Hydrostatic Compression Conditions Using Dispersion Corrections to Conventional Density Functionals (DFT-D) SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID SMALL ORGANIC-MOLECULES; PENTAERYTHRITOL TETRANITRATE PETN; DER-WAALS CORRECTION; AB-INITIO; SOLID NITROMETHANE; BLIND TEST; 1,3,5,7-TETRANITRO-1,3,5,7-TETRAAZACYCLOOCTANE HMX; DYNAMICS SIMULATIONS; NEUTRON-DIFFRACTION; GAMMA-RDX AB Theoretical predictions of the crystallographic properties of a series of 10 energetic molecular crystals have been done using a semiempirical correction to account for the van der Waals interactions in conventional density functional theory (termed DFT-D) as implemented in a pseudopotential plane-wave code This series contains compounds representative for energetic materials applications, that is, hexahydro-1,3,5-trinitro-1,3,5-s triazine (alpha- and gamma-RDX phases), 1,3,5.7-tetramtro-1,3,5,7-tetraaza-cyclooctane (beta-, alpha-, and delta-HMX phases), 2,4,6,8,10,12-hexanitrohexaazaisowurtzitane (CL20) (epsilon-, beta-, and gamma-HNIW phases), nitromethane (NM), trans-1,2,-dinitrocyclopropane, 1,2,3,5,7-pentanitrocubane (PNC), pentaerythruol tetramtrate (PETN), 2,4,6-trinitro-1,3,5-benzenetriamine (TATB), 2,4,6-trinitrotoluene (TNT-I phase), and 1,1-diammo-2,2-dinitroethylene (FOX-7), systems belonging to diverse chemical classes that encompass nitramines, nitroalkanes, nitroaromatics, nitrocubanes, nitrate esters. and amino-nitro derivatives At ambient pressure, we show that the DFT-D method is capable of providing an accurate description of the crystallographic lattice parameters with error bars significantly lower than those obtained using conventional DFT Practically, for all crystals considered in this study the predicted lattice parameters are within 2% from the corresponding experimental data [alpha-RDX (1 58%), beta-HMX (0 64%). epsilon-HNIW (1 42%), NM (0.75%), DNCP (1 99%), TATB (1.74%), TNT-I (0 92%), PNC(0.78%), PETN(1.35%), FOX-7(1.57%)1, with the best level of agreement being found for systems where experimental data have been collected at low temperatures A similar good agreement of the predicted and experimental crystallographic parameters was obtained under hydrostatic compression conditions as demonstrated for the cases of RDX, HMX. CL20, NM, TATB, and PETN crystals These results indicate that the DFT-D method provides significant improvements for description of intermolecular interactions in molecular crystals at both ambient and high pressures relative to conventional DFT. In this last case, large errors of the predicted lattice parameters have been found at low pressures; theoretical values approach the experimental results only at pressures in excess of 6 GPa C1 [Sorescu, Dan C.] Natl Energy Technol Lab, US Dept Energy, Pittsburgh, PA 15236 USA. [Rice, Betsy M.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Sorescu, DC (reprint author), Natl Energy Technol Lab, US Dept Energy, Pittsburgh, PA 15236 USA. NR 65 TC 86 Z9 92 U1 5 U2 70 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD APR 15 PY 2010 VL 114 IS 14 BP 6734 EP 6748 DI 10.1021/jp100379a PG 15 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 579BP UT WOS:000276341700074 ER PT J AU Wolinsky, MA Swenson, JB Litchfield, N McNinch, JE AF Wolinsky, M. A. Swenson, J. B. Litchfield, N. McNinch, J. E. TI Coastal progradation and sediment partitioning in the Holocene Waipaoa Sedimentary System, New Zealand SO MARINE GEOLOGY LA English DT Article DE deltas; accommodation; sediment budget; shoreline trajectory; autostratigraphy; inverse modeling ID GRAVEL-BED RIVER; NORTH-ISLAND; POVERTY BAY; CONTINENTAL-MARGIN; EAST-COAST; SEA-LEVEL; SHORELINE; TRANSPORT; STRATIGRAPHY; ACCRETION AB Over the late Holocene highstand, the shoreline at Poverty Bay, NZ migrated 12 km seaward, fed by sediment from the Waipaoa river. Paleo-shorelines indicate steadily decelerating progradation, possibly signaling changes in forcing on the Waipaoa Sedimentary System. To isolate the cause of this progradation slowdown we reconstruct late Holocene tectonics and stratigraphy over the Waipaoa coastal plain and nearshore from 7 ka-present. We find that decreasing rates of sediment storage by coastal progradation were driven by increasing tectonic storage in the steadily subsiding but rapidly growing coastal plain, such that net terrestrial storage remained constant at similar to 0.8 Mt/yr. Hence changes in shoreline migration were due to autogenic increases in accommodation rather than allogenic changes in forcing. Furthermore, while the Waipaoa sediment load is primarily mud, reconstructions suggest that progradation was largely controlled by the supply of coarse-grained sediment. Our results suggest that in coastal systems such as the Waipaoa, where progradation is confined and wave energy is high, net accumulation of muds occurs only behind the prograding sandy shoreface, which shelters them from wave attack. Accounting for mud storage in the Waipaoa coastal plain and Poverty Bay suggests that export of muddy sediment to the Waipaoa shelf remained roughly constant at similar to 2.0 Mt/yr from 7 ka until the onset of anthropogenic deforestation in the 19th century. (C) 2009 Elsevier B.V. All rights reserved. C1 [Wolinsky, M. A.] St Anthony Falls Lab, Minneapolis, MN 55414 USA. [Swenson, J. B.] Univ Minnesota, Dept Geol Sci, Duluth, MN 55812 USA. [Litchfield, N.] GNS Sci, Lower Hutt, New Zealand. [McNinch, J. E.] USACE Field Res Facil, Duck, NC 27949 USA. [McNinch, J. E.] Virginia Inst Marine Sci, Gloucester Point, VA 23062 USA. [McNinch, J. E.] Coll William & Mary, Gloucester Point, VA 23062 USA. RP Wolinsky, MA (reprint author), Shell Bellaire Technol Ctr, 3737 Bellaire Blvd, Houston, TX 77025 USA. EM Matthew.Wolinsky@shell.com NR 53 TC 18 Z9 18 U1 0 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0025-3227 J9 MAR GEOL JI Mar. Geol. PD APR 15 PY 2010 VL 270 IS 1-4 SI SI BP 94 EP 107 DI 10.1016/j.margeo.2009.10.021 PG 14 WC Geosciences, Multidisciplinary; Oceanography SC Geology; Oceanography GA 576IF UT WOS:000276137100008 ER PT J AU Litchinitser, N Scalora, M AF Litchinitser, Natalia Scalora, Michael TI Special Issue Nonlinear Optics in Metamaterials SO OPTICS COMMUNICATIONS LA English DT Editorial Material ID NEGATIVE-INDEX C1 [Litchinitser, Natalia] SUNY Buffalo, Dept Elect Engn, Buffalo, NY 14260 USA. [Scalora, Michael] USA, Charles M Bowden Res Facil, AMRDEC, RDECOM,AMSRD,AMR,WS,ST, Redstone Arsenal, AL 35898 USA. RP Litchinitser, N (reprint author), SUNY Buffalo, Dept Elect Engn, Buffalo, NY 14260 USA. EM natashal@buffalo.edu NR 4 TC 0 Z9 0 U1 1 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD APR 15 PY 2010 VL 283 IS 8 SI SI BP 1579 EP 1580 DI 10.1016/j.optcom.2010.01.001 PG 2 WC Optics SC Optics GA 570TR UT WOS:000275701500001 ER PT J AU Wang, LJ Xu, ZY Sadler, BM AF Wang, Leijie Xu, Zhengyuan Sadler, Brian M. TI Non-line-of-sight ultraviolet link loss in noncoplanar geometry SO OPTICS LETTERS LA English DT Article ID COMMUNICATION; PERFORMANCE AB Various path loss models have been developed for solar blind non-line-of-sight UV communication links under an assumption of coplanar source beam axis and receiver pointing direction. This work further extends an existing single-scattering coplanar analytical model to noncoplanar geometry. The model is derived as a function of geometric parameters and atmospheric characteristics. Its behavior is numerically studied in different noncoplanar geometric settings. (C) 2010 Optical Society of America C1 [Wang, Leijie; Xu, Zhengyuan] Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. [Sadler, Brian M.] USA, Res Lab, RDRL CIN T, Adelphi, MD 20783 USA. RP Xu, ZY (reprint author), Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. EM dxu@ee.ucr.edu FU US Army Research Office (USARO) [W911NF-09-1-0293]; US Army Research Laboratory (USARL) [DAAD1901-2-0011] FX This work was supported by US Army Research Office (USARO) grant W911NF-09-1-0293 and US Army Research Laboratory (USARL) grant DAAD1901-2-0011. NR 8 TC 33 Z9 35 U1 1 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD APR 15 PY 2010 VL 35 IS 8 BP 1263 EP 1265 PG 3 WC Optics SC Optics GA 585WN UT WOS:000276861100050 PM 20410987 ER PT J AU Vasic, R Sadowski, JT Choi, YJ Zhou, HD Wiebe, CR Cheong, SW Rowe, JE Ulrich, MD AF Vasic, R. Sadowski, J. T. Choi, Y. J. Zhou, H. D. Wiebe, C. R. Cheong, S. W. Rowe, J. E. Ulrich, M. D. TI Surface reconstruction of hexagonal Y-doped HoMnO3 and LuMnO3 studied using low-energy electron diffraction SO PHYSICAL REVIEW B LA English DT Article ID MANGANITES; YMNO3; SRTIO3(100); PEROVSKITES; TRANSITION AB We have investigated the (0001) surfaces of several hexagonal manganite perovskites by low-energy electron diffraction (LEED) in order to determine if the surface periodicity is different from that of the bulk materials. These LEED studies were conducted using near-normal incidence geometry with a low energy electron microscope (LEEM)/LEED apparatus from room temperature to 1200 degrees C and with an electron energy in the range of 15-50 eV. Diffraction patterns showed features of bulk-terminated periodicity as well as a 2 x 2 surface reconstruction. Possible origins for this surface reconstruction structure are discussed and comparisons are made with surface studies of other complex oxides. C1 [Vasic, R.] Yeshiva Univ, Dept Phys, New York, NY 10033 USA. [Sadowski, J. T.] Brookhaven Natl Lab, Ctr Funct Nanomat, Upton, NY 11973 USA. [Choi, Y. J.; Cheong, S. W.] Rutgers State Univ, Dept Phys & Astron, Piscataway, NJ 08854 USA. [Zhou, H. D.; Wiebe, C. R.] Florida State Univ, Condensed Matter Grp Expt, NHMFL, Tallahassee, FL 32310 USA. [Rowe, J. E.; Ulrich, M. D.] N Carolina State Univ, Dept Phys, Raleigh, NC 27695 USA. [Ulrich, M. D.] USA, Res Off, Div Phys, Res Triangle Pk, NC 27709 USA. RP Vasic, R (reprint author), Yeshiva Univ, Dept Phys, New York, NY 10033 USA. RI Zhou, Haidong/O-4373-2016; OI Sadowski, Jerzy/0000-0002-4365-7796 FU U.S. Department of Energy (DOE), Office of Basic Energy Sciences (BES) [DE-FG02-07ER46382, DE-AC02-98CH10886]; National Science Foundation through NSF [DMR0449569]; State of Florida FX We acknowledge Army Research Office for support for this research. Work at Rutgers was supported by U.S. Department of Energy (DOE), Office of Basic Energy Sciences (BES) DE-FG02-07ER46382. The NHMFL is supported by contractual agreement between the National Science Foundation through NSF under Grant No. DMR0449569 and the State of Florida. Research carried out in part at the Center for Functional Nanomaterials, Brookhaven National Laboratory, which is supported by the DOE BES, under Contract No. DE-AC02-98CH10886. The National Synchrotron Light Source, Brookhaven National Laboratory, is supported by the DOE BES, under Contract No. DE-AC02-98CH10886. NR 32 TC 0 Z9 0 U1 0 U2 22 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD APR 15 PY 2010 VL 81 IS 16 AR 165417 DI 10.1103/PhysRevB.81.165417 PG 6 WC Physics, Condensed Matter SC Physics GA 590HX UT WOS:000277217200094 ER PT J AU Pang, YP Davis, J Wang, SH Park, JG Nambiar, MP Schmidt, JJ Millard, CB AF Pang, Yuan-Ping Davis, Jon Wang, Shaohua Park, Jewn Giew Nambiar, Madhusoodana P. Schmidt, James J. Millard, Charles B. TI Small Molecules Showing Significant Protection of Mice against Botulinum Neurotoxin Serotype A SO PLOS ONE LA English DT Article ID AB-INITIO CALCULATIONS; DYNAMICS SIMULATION; ZINC ENDOPEPTIDASE; TOXIN; INHIBITORS; IDENTIFICATION; AMBER; RECOGNITION; PERFORMANCE; MANAGEMENT AB Botulinum neurotoxin serotype A (BoNTA) causes a life-threatening neuroparalytic disease known as botulism that could afflict large, unprotected populations if the toxin were employed in an act of bioterrorism. Current post-exposure therapy is limited to symptomatic treatment or passive immunization that is effective for treating infant botulism at a cost of US $45,300 per treatment regimen. Antibodies can neutralize the extracellular but not the intracellular BoNTA. Moreover, antibody production, storage, and administration in a mass casualty scenario pose logistical challenges. Alternatively, small-molecule inhibitors of BoNTA endopeptidase (BoNTAe) are sought to antagonize the extracellular or intracellular toxin. While several such molecules reportedly demonstrated efficacy in protecting cells against BoNTA, there is scant information to show that small molecules can significantly protect mammals against BoNTA. Herein we report the development of effective small-molecules BoNTAe inhibitors with promising in vivo pharmacokinetics. One such molecule has an in vivo half-life of 6.5 hours and is devoid of obvious sign of toxicity. Pre-treatment with this molecule at 2 mg/kg protected 100% and 70% of treated mice against BoNTA at 5 times of its median-lethal dose during the periods of 2 and 4 half-lives of the inhibitor, respectively. In contrast, 40% and 0% of untreated mice survived during the respective periods. Similar levels of protection were also observed with two other small molecules. These results demonstrate that small molecules can significantly protect mice against BoNTA and support the pursuit of small-molecule antagonists as a cost-effective alternative or as an adjunct to passive immunity for treating botulism. C1 [Pang, Yuan-Ping; Wang, Shaohua; Park, Jewn Giew] Mayo Clin, Comp Aided Mol Design Lab, Rochester, MN 55905 USA. [Davis, Jon; Nambiar, Madhusoodana P.; Millard, Charles B.] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD USA. [Schmidt, James J.] USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. RP Pang, YP (reprint author), Mayo Clin, Comp Aided Mol Design Lab, Rochester, MN 55905 USA. EM pang@mayo.edu; charles.b.millard@us.army.mil OI Pang, Yuan-Ping/0000-0003-0838-2560 FU United States Army Medical Research and Materiel Command [W81XWH-04-2-0001, W81XWH-08-1-0154]; United States Army Research Office [W911NF-09-1-0095]; United States Defense Threat Reduction Agency [3.10023_07_RD_B, 3.10014_08_WR_B]; University of Minnesota Supercomputing Institute FX This work was supported by the United States Army Medical Research and Materiel Command (W81XWH-04-2-0001 and W81XWH-08-1-0154), the United States Army Research Office (W911NF-09-1-0095), the United States Defense Threat Reduction Agency (3.10023_07_RD_B and 3.10014_08_WR_B), and the University of Minnesota Supercomputing Institute. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the United States Army, Navy or the Department of Defense. NR 45 TC 28 Z9 28 U1 0 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 13 PY 2010 VL 5 IS 4 AR e10129 DI 10.1371/journal.pone.0010129 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 583UV UT WOS:000276706300002 PM 20405003 ER PT J AU Fazio, E Belardini, A Alonzo, M Centini, M Chauvet, M Devaux, F Scalora, M AF Fazio, Eugenio Belardini, Alessandro Alonzo, Massimo Centini, Marco Chauvet, Mathieu Devaux, Fabrice Scalora, Michael TI Observation of photorefractive simultons in lithium niobate SO OPTICS EXPRESS LA English DT Article ID DISPERSIVE DIELECTRIC FIBERS; NONLINEAR OPTICAL PULSES; 2ND-HARMONIC GENERATION; QUADRATIC MEDIUM; SOLITARY WAVES; STEADY-STATE; SOLITONS; BEAM; TRANSMISSION; BOUNDARY AB Spatial and temporal locking of fundamental and second harmonic pulses was realized by means of photorefractive nonlinearity and highly mismatched harmonic generation. Due to the presence of both phase-locked and unlocked second harmonic pulses, a twin simultonic state was observed. Simultonic filamentation occurring at high pumping rates allowed us to determine a relation between the simulton's waist and its intensity. (C) 2010 Optical Society of America C1 [Fazio, Eugenio; Belardini, Alessandro; Alonzo, Massimo; Centini, Marco] Univ Roma La Sapienza, Dipartimento Energet, Ultrafast Photon Lab, I-00161 Rome, Italy. [Fazio, Eugenio; Belardini, Alessandro; Alonzo, Massimo; Centini, Marco] Univ Roma La Sapienza, CNISM, I-00161 Rome, Italy. [Chauvet, Mathieu; Devaux, Fabrice] Univ Franche Comte, CNRS, UMR 6174, Inst FEMTO ST,Dept Opt, F-25030 Besancon, France. [Scalora, Michael] USA, Aviat & Missile Command, RDECOM, Charles M Bowden Res Facil, Redstone Arsenal, AL 35803 USA. RP Fazio, E (reprint author), Univ Roma La Sapienza, Dipartimento Energet, Ultrafast Photon Lab, Via Scarpa 16, I-00161 Rome, Italy. EM eugenio.fazio@uniroma1.it RI devaux, fabrice/A-9231-2013; OI BELARDINI, ALESSANDRO/0000-0002-7574-0332; CENTINI, MARCO/0000-0003-0625-0054; FAZIO, Eugenio/0000-0002-0995-0702 FU Sapienza Universita di Roma FX This work has been supported by the contracts from Sapienza Universita di Roma A) ricerche universitarie 2007(processi ottici nonlineari di generazione di armonica in materiali massivi e nanostrutturati altamente dispersivi) and B) ricerche di ateneo federato 2008 (generazione di seconda armonica in sistemi dispersivi e nano strutturati). E. F. is grateful to the Universite de Franche Comte for the visiting professorship under which part of this work has been performed. A. M. D. G. NR 27 TC 5 Z9 5 U1 0 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD APR 12 PY 2010 VL 18 IS 8 BP 7972 EP 7981 DI 10.1364/OE.18.007972 PG 10 WC Optics SC Optics GA 582PP UT WOS:000276610300045 PM 20588640 ER PT J AU Hrozhyk, UA Serak, SV Tabiryan, NV Hoke, L Steeves, DM Kimball, BR AF Hrozhyk, Uladzimir A. Serak, Svetlana V. Tabiryan, Nelson V. Hoke, Landa Steeves, Diane M. Kimball, Brian R. TI Azobenzene liquid crystalline materials for efficient optical switching with pulsed and/or continuous wave laser beams SO OPTICS EXPRESS LA English DT Article ID PHOTOISOMERIZATION; FULLERENES; SENSOR; STATE; FILMS AB This study compares optical switching capabilities of liquid crystal (LC) materials based on different classes of azobenzene dyes. LCs based on molecules containing benzene rings with nearly symmetrical pi-pi conjugation respond more efficiently to a cw beam than to a nanosecond laser pulse and maintain the changes induced by the beam for tens of hours. Using azo dye molecules containing two benzene rings with push-pull pi-pi conjugation we demonstrate high photosensitivity to both a cw beam as well as nanosecond laser pulse with only 1 s relaxation of light-induced changes in material properties. Even faster, 1 ms restoration time is obtained for azo dye molecules containing hetaryl (benzothiazole) ring with enhanced pushpull pi-pi conjugation. These materials respond most efficiently to pulsed excitation while discriminating cw radiation. 2010 Optical Society of America C1 [Hrozhyk, Uladzimir A.; Serak, Svetlana V.; Tabiryan, Nelson V.] Beam Engn Adv Measurements Co, Winter Pk, FL 32789 USA. [Hoke, Landa; Steeves, Diane M.; Kimball, Brian R.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Hrozhyk, UA (reprint author), Beam Engn Adv Measurements Co, 809 S Orlando Ave,Suite I, Winter Pk, FL 32789 USA. EM brian.r.kimball@us.army.mil NR 27 TC 53 Z9 53 U1 1 U2 22 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD APR 12 PY 2010 VL 18 IS 8 BP 8697 EP 8704 DI 10.1364/OE.18.008697 PG 8 WC Optics SC Optics GA 582PP UT WOS:000276610300118 PM 20588713 ER PT J AU Cerco, CF Noel, MR AF Cerco, Carl F. Noel, Mark R. TI Monitoring, modeling, and management impacts of bivalve filter feeders in the oligohaline and tidal fresh regions of the Chesapeake Bay system SO ECOLOGICAL MODELLING LA English DT Article DE Chesapeake Bay; Potomac River; Eutrophication model; Rangia cuneata; Corbicula fluminea ID CORBICULA-FLUMINEA BIVALVIA; ASIATIC CLAM; POTOMAC RIVER; EUTROPHICATION; PHYTOPLANKTON; DYNAMICS; SEDIMENT; MARYLAND; ESTUARY; GROWTH AB Populations of bivalve filter feeders are distributed throughout the oligohaline waters of the Chesapeake Bay system and, to a lesser extent, in tidal fresh waters as well. Previous studies indicate these bivalves significantly diminish phytoplankton concentrations in one major tributary, the Potomac River, and observed chlorophyll concentrations suggest bivalve influence on phytoplankton in other oligohaline reaches. We incorporated a model of these bivalves into an existing eutrophication model of the system. The model indicated that bivalves may reduce phytoplankton concentrations in oligohaline and tidal fresh waters throughout the system but the most significant effects were noted in the Potomac and Patuxent tributaries. Bivalve impacts were related to hydraulic residence time. The greatest phytoplankton reductions occurred in the regions with the longest residence time. Model carbon and nutrient budgets indicated bivalves removed 14% to 40% of the carbon load, 11% to 23% of the nitrogen load, and 37% to 84% of the phosphorus load to the regions where their impact on computed chlorophyll was greatest. Published by Elsevier B.V. C1 [Cerco, Carl F.; Noel, Mark R.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Cerco, CF (reprint author), USA, Engineer Res & Dev Ctr, Mail Stop EP-W,3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM carl.f.cerco@usace.army.mil NR 33 TC 9 Z9 9 U1 4 U2 19 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3800 J9 ECOL MODEL JI Ecol. Model. PD APR 10 PY 2010 VL 221 IS 7 BP 1054 EP 1064 DI 10.1016/j.ecolmodel.2009.07.024 PG 11 WC Ecology SC Environmental Sciences & Ecology GA 572DT UT WOS:000275808200010 ER PT J AU Wang, Y Li, YS Lucca, SLD Simovic, M Tsokos, GC Lucca, JJD AF Wang, Ying Li, Yansong Lucca, Shawn L. Dalle Simovic, Milomir Tsokos, George C. Lucca, Jurandir J. Dalle TI Decay accelerating factor (CD55) protects neuronal cells from chemical hypoxia-induced injury SO JOURNAL OF NEUROINFLAMMATION LA English DT Article ID TRAUMATIC BRAIN-INJURY; MEMBRANE ATTACK COMPLEX; CENTRAL-NERVOUS-SYSTEM; D-ASPARTATE RECEPTOR; TYROSINE PHOSPHORYLATION; CEREBRAL-ISCHEMIA; DENDRITIC SPINES; DIFFERENT MODES; ACTIVATION; SRC AB Background: Activated complement system is known to mediate neuroinflammation and neurodegeneration following exposure to hypoxic-ischemic insults. Therefore, inhibition of the complement activation cascade may represent a potential therapeutic strategy for the management of ischemic brain injury. Decay-accelerating factor (DAF, also known as CD55) inhibits complement activation by suppressing the function of C3/C5 convertases, thereby limiting local generation or deposition of C3a/C5a and membrane attack complex (MAC or C5b-9) production. The present study investigates the ability of DAF to protect primary cultured neuronal cells subjected to sodium cyanide (NaCN)-induced hypoxia from degeneration and apoptosis. Methods: Cultured primary cortical neurons from embryonic Sprague-Dawley rats were assigned one of four groups: control, DAF treatment alone, hypoxic, or hypoxic treated with DAF. Hypoxic cultures were exposed to NaCN for 1 hour, rinsed, followed by 24 hour exposure to 200 ng/ml of recombinant human DAF in normal medium. Human DAF was used in the present study and it has been shown to effectively regulate complement activation in rats. Neuronal cell function, morphology and viability were investigated by measuring plateau depolarization potential, counting the number dendritic spines, and observing TUNEL and MTT assays. Complement C3, C3a, C3a receptor (R) production, C3a-C3aR interaction and MAC formation were assessed along with the generation of activated caspase-9, activated caspase-3, and activated Src. Results: When compared to controls, hypoxic cells had fewer dendritic spines, reduced plateau depolarization accompanied by increased apoptotic activity and accumulation of MAC, as well as up-regulation of C3, C3a and C3aR, enhancement of C3a-C3aR engagement, and elevated caspase and Src activity. Treatment of hypoxic cells with 200 ng/ml of recombinant human DAF resulted in attenuation of neuronal apoptosis and exerted significant protection against neuronal dendritic spine loss and plateau depolarization reduction. Furthermore, treatment with DAF resulted in decreased accumulation of C3a, MAC, C3a-C3aR interaction, caspase-9, activated caspase-3, and pTyr416-Src (activated Src) tyrosine kinase. Conclusion: DAF was found to reduce neuronal cell death and apoptosis in NaCN induced hypoxia. This effect is attributed to the ability of DAF to limit complement activation and inhibit the activity of Src and caspases 9 and 3. This study supports the inhibiting of complement as a neuroprotective strategy against CNS ischemia/reperfusion injury. C1 [Wang, Ying; Li, Yansong; Simovic, Milomir; Lucca, Jurandir J. Dalle] Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. [Lucca, Shawn L. Dalle] Clin Res Management Inc, Frederick, MD 21701 USA. [Tsokos, George C.] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Rheumatol, Boston, MA 02115 USA. RP Lucca, JJD (reprint author), Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. EM jurandir.dallelucca@us.army.mil FU Department of Defense; Army Technology Objective for Damage Control Resuscitation FX The authors wish to thank Dr. Feng Yang for the whole cell recordings and scientific consultation, Dr. Yuanyuan Ji for technical expertise in primary neuronal culture, and the Department of Defense Combat Casualty Care Research Program and Army Technology Objective for Damage Control Resuscitation for supporting this work. NR 53 TC 18 Z9 18 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-2094 J9 J NEUROINFLAMM JI J. Neuroinflamm. PD APR 9 PY 2010 VL 7 AR 24 DI 10.1186/1742-2094-7-24 PG 13 WC Immunology; Neurosciences SC Immunology; Neurosciences & Neurology GA 595SL UT WOS:000277633300001 PM 20380727 ER PT J AU Crum-Cianflone, N Roediger, MP Eberly, L Headd, M Marconi, V Ganesan, A Weintrob, A Barthel, RV Fraser, S Agan, BK AF Crum-Cianflone, Nancy Roediger, Mollie Poehlman Eberly, Lynn Headd, Maryam Marconi, Vincent Ganesan, Anuradha Weintrob, Amy Barthel, R. Vincent Fraser, Susan Agan, Brian K. CA Infect Dis Clinical Res Program HI TI Increasing Rates of Obesity among HIV-Infected Persons during the HIV Epidemic SO PLOS ONE LA English DT Article ID ACTIVE ANTIRETROVIRAL THERAPY; HUMAN-IMMUNODEFICIENCY-VIRUS; WEIGHT-LOSS; BODY-COMPOSITION; COHORT; RISK; ERA; OVERWEIGHT; SURVIVAL; ADULTS AB Background: The prevalence and factors associated with overweight/obesity among human immunodeficiency virus (HIV)-infected persons are unknown. Methods: We evaluated prospective data from a U. S. Military HIV Natural History Study (1985-2004) consisting of early diagnosed patients. Statistics included multivariate linear regression and longitudinal linear mixed effects models. Results: Of 1682 patients, 2% were underweight, 37% were overweight, and 9% were obese at HIV diagnosis. Multivariate predictors of a higher body mass index (BMI) at diagnosis included more recent year of HIV diagnosis, older age, African American race, and earlier HIV stage (all p < 0.05). The majority of patients (62%) gained weight during HIV infection. Multivariate factors associated with a greater increase in BMI during HIV infection included more recent year of diagnosis, lower BMI at diagnosis, higher CD4 count, lower HIV RNA level, lack of AIDS diagnosis, and longer HIV duration (all p < 0.05). Nucleoside agents were associated with less weight gain; other drug classes had no significant impact on weight change in the HAART era. Conclusions: HIV-infected patients are increasingly overweight/obese at diagnosis and during HIV infection. Weight gain appears to reflect improved health status and mirror trends in the general population. Weight management programs may be important components of HIV care. C1 [Crum-Cianflone, Nancy; Roediger, Mollie Poehlman; Eberly, Lynn; Marconi, Vincent; Ganesan, Anuradha; Weintrob, Amy; Barthel, R. Vincent; Fraser, Susan; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Crum-Cianflone, Nancy] USN, Infect Dis Clin, San Diego Med Ctr, San Diego, CA 92152 USA. [Crum-Cianflone, Nancy; Headd, Maryam] San Diego State Univ, Grad Sch Publ Hlth, San Diego, CA 92182 USA. [Roediger, Mollie Poehlman; Eberly, Lynn] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Marconi, Vincent] San Antonio Mil Med Ctr, Infect Dis Clin, San Antonio, TX USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Infect Dis Clin, Bethesda, MD USA. [Weintrob, Amy] Walter Reed Army Med Ctr, Infect Dis Clin, Washington, DC 20307 USA. [Barthel, R. Vincent] USN, Med Ctr Portsmouth, Infect Dis Clin, Portsmouth, VA USA. [Fraser, Susan] Tripler Med Ctr, Infect Dis Clin, Honolulu, HI USA. RP Crum-Cianflone, N (reprint author), Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. EM nancy.crum@med.navy.mil RI Marconi, Vincent/N-3210-2014; OI Marconi, Vincent/0000-0001-8409-4689; Eberly, Lynn/0000-0003-4763-330X; Agan, Brian/0000-0002-5114-1669 FU Infectious Disease Clinical Research Program (IDCRP); Department of Defense (DoD); National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [Y1-AI-5072] FX Support for this work was provided by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 40 TC 62 Z9 63 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 9 PY 2010 VL 5 IS 4 AR e10106 DI 10.1371/journal.pone.0010106 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 580WU UT WOS:000276482100019 PM 20419086 ER PT J AU Kelly, EP Puri, B Sun, W Falgout, B AF Kelly, Eileen P. Puri, Beena Sun, Wellington Falgout, Barry TI Identification of mutations in a candidate dengue 4 vaccine strain 341750 PDK20 and construction of a full-length cDNA clone of the PDK20 vaccine candidate SO VACCINE LA English DT Article DE Dengue virus; Vaccine virus mutation analysis; Infectious clone ID BORNE ENCEPHALITIS-VIRUS; HEPATITIS-C VIRUS; AMINO-ACID SUBSTITUTION; DOUBLE-STRANDED-RNA; ENVELOPE PROTEIN; VIRAL-RNA; HEMORRHAGIC-FEVER; CRYSTAL-STRUCTURE; NS1 PROTEIN; NONSTRUCTURAL GLYCOPROTEIN-NS1 AB Dengue 4 virus strain 341750 serially passaged 20 times in primary dog kidney (PDK) cells was shown to have reduced infectivity for rhesus monkeys but was immunogenic and protected the monkeys from challenge with low passage parent dengue 4 virus. The dengue 4 PDK20 virus was also shown to be attenuated for human volunteers. We compared the genomic nucleotide sequences of low passage parent and PDK20 attenuated vaccine strains and identified 11 nucleotide (nt) substitutions in the PDK20 genome. Five mutations caused amino acid changes in viral proteins E (N366N/S), NS1 (E146Q), NS4B (S/L112L and A240V), and NS5 (F/L790L). Silent mutations occurred in genes encoding NS1 (nt 2609), NS3 (nt 6113, 6230 and 6239) and NS5 (nt 8081 and 8588). A full-length cDNA clone of the dengue 4 strain 341750 PDK20 was constructed and RNA transcripts of the clone were infectious in monkey kidney (LLC-MK(2)) and Aedes albopictus (C6/36) cells. The sequence analysis and availability of an infectious clone provide molecular tools to investigate the basis for the attenuation of dengue 4 virus. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Kelly, Eileen P.; Sun, Wellington] Walter Reed Army Inst Res, Div Virus Dis, Dept Virus Dis, Silver Spring, MD 20910 USA. [Puri, Beena] USN, Dept Infect Dis, Viral Dis Program, Med Res Ctr, Silver Spring, MD USA. [Falgout, Barry] US FDA, Ctr Biol Evaluat & Res, Bethesda, MD 20952 USA. RP Kelly, EP (reprint author), Walter Reed Army Inst Res, Div Virus Dis, Dept Virus Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM eileen.kelly@amedd.army.mil; beena.puri@fda.hhs.gov; wellington.sun@fda.hhs.gov; barry.falgout@fda.hhs.gov FU United States Army Medical Research and Materiel Command FX We thank Dr. Ken Eckels, Walter Reed Army Institute of Research, for providing the lyophilized parent and vaccine candidate viruses. The studies were supported by the United States Army Medical Research and Materiel Command. NR 53 TC 14 Z9 14 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD APR 9 PY 2010 VL 28 IS 17 BP 3030 EP 3037 DI 10.1016/j.vaccine.2009.10.084 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 586CE UT WOS:000276877900016 PM 19874927 ER PT J AU Sloan, SD Tsoflias, GP Steeples, DW AF Sloan, Steven D. Tsoflias, Georgios P. Steeples, Don W. TI Ultra-shallow seismic imaging of the top of the saturated zone SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article ID WATER-TABLE; REFLECTION; AQUIFER AB We collected ultra-shallow seismic-reflection data to image the near-surface stratigraphy of a Kansas River point bar. We were successful in identifying a discontinuous clay layer and the top of the saturated zone at depths of 0.95 and 1.4 m. Seismic walkaway data collected using various .22-caliber ammunition show that decreased source energy is necessary to generate higher frequencies and prevent clipping of critical near-offset traces needed to identify ultra-shallow reflections. The seismic reflections exhibited average normal moveout velocities of 180-195 m/s with dominant frequencies of 200-450 Hz. Coincident subsurface features were also imaged using 200-MHz ground-penetrating radar. This study presents the shallowest seismic reflection from the top of the saturated zone reported in the literature to date and further demonstrates the potential of using seismic-reflection methods for ultra-shallow imaging of the subsurface as a stand-alone tool or in conjunction with other high-resolution geophysical techniques. Citation: Sloan, S. D., G. P. Tsoflias, and D. W. Steeples (2010), Ultra-shallow seismic imaging of the top of the saturated zone, Geophys. Res. Lett., 37, L07405, doi:10.1029/2010GL043034. C1 [Sloan, Steven D.] USA, Corps Engineers, Engineer Res & Dev Ctr, CEERD GS S, Vicksburg, MS 39180 USA. [Tsoflias, Georgios P.; Steeples, Don W.] Univ Kansas, Dept Geol, Lawrence, KS 66045 USA. RP Sloan, SD (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, CEERD GS S, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM steven.d.sloan@usace.army.mil; tsoflias@ku.edu; don@ku.edu NR 11 TC 1 Z9 1 U1 0 U2 7 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0094-8276 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD APR 8 PY 2010 VL 37 AR L07405 DI 10.1029/2010GL043034 PG 5 WC Geosciences, Multidisciplinary SC Geology GA 581SN UT WOS:000276544900008 ER PT J AU Wagner, GW Procell, LR Sorrick, DC Lawson, GE Wells, CM Reynolds, CM Ringelberg, DB Foley, KL Lumetta, GJ Blanchard, DL AF Wagner, George W. Procell, Lawrence R. Sorrick, David C. Lawson, Glenn E. Wells, Claire M. Reynolds, Charles M. Ringelberg, David B. Foley, Karen L. Lumetta, Gregg J. Blanchard, David L., Jr. TI All-Weather Hydrogen Peroxide-Based Decontamination of CBRN Contaminants SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH LA English DT Article ID CHROMATOGRAPHY MASS-SPECTROMETRY; CHEMICAL WARFARE SAMPLES; NERVE AGENT VX; DEGRADATION-PRODUCTS; SULFUR MUSTARD; DETOXIFICATION; OXIDATION; SARIN AB A hydrogen peroxide-based decontaminant, Decon Green, is efficacious for the decontamination of chemical agents VX (S-2-(diisopropylamino)ethyl O-ethyl methylphosphonothioate), GD (Soman, pinacolyl methylphosphonofluoridate), and HD (mustard, bis(2-chloroethyl) sulfide); the biological agent anthrax (Bacillus anthracis); and radiological isotopes (137)Cs and (60)Co; thus demonstrating the ability of this decontamination approach to ameliorate the aftermath of all three types of weapons of mass destruction (WMD). Reaction mechanisms afforded for the chemical agents are discussed as are rationales for the enhanced removal efficacy of recalcitrant (60)Co on certain surfaces. Decontaminants of this nature can be deployed, and are effective, at very low temperatures (-32 degrees C), as shown for studies done with VX and HD simulants, without the need for external heat sources. Finally, the efficacy of a lower-logistics, dry decontaminant powder concentrate (utilizing the solid active-oxygen compounds peracetyl borate and Peroxydone) which can be reconstituted with water in the field prior to use, is presented. C1 [Wagner, George W.; Procell, Lawrence R.; Sorrick, David C.] USA, ECBC, Aberdeen Proving Ground, MD 21010 USA. [Lawson, Glenn E.; Wells, Claire M.] USN, Ctr Surface Warfare, Dahlgren, VA 22448 USA. [Reynolds, Charles M.; Ringelberg, David B.; Foley, Karen L.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Lumetta, Gregg J.; Blanchard, David L., Jr.] Pacific NW Natl Lab, Richland, WA 99352 USA. RP Wagner, GW (reprint author), USA, ECBC, Aberdeen Proving Ground, MD 21010 USA. EM george.wagner@us.army.mil FU Defense Threat Reduction Agency (DTRA) [CDEC3007, BA06DEC052]; [206023.84BP0] FX The many participants who contributed to this work can be found in the references to the prior work, and they are gratefully acknowledged for their technical and experimental endeavors. Support of this work was provided under Project Nos. 206023.84BP0 and CDEC3007, and Defense Threat Reduction Agency (DTRA) Projects CDEC3007 and BA06DEC052. NR 39 TC 26 Z9 27 U1 2 U2 39 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0888-5885 J9 IND ENG CHEM RES JI Ind. Eng. Chem. Res. PD APR 7 PY 2010 VL 49 IS 7 BP 3099 EP 3105 DI 10.1021/ie9019177 PG 7 WC Engineering, Chemical SC Engineering GA 574TI UT WOS:000276016100008 ER PT J AU Dmytriiev, O Meitzler, T Bankowski, E Slavin, A Tiberkevich, V AF Dmytriiev, O. Meitzler, T. Bankowski, E. Slavin, A. Tiberkevich, V. TI Spin wave excitations of a magnetic pillar with dipolar coupling between the layers SO JOURNAL OF PHYSICS-CONDENSED MATTER LA English DT Article AB It is demonstrated analytically that the spectrum of small-amplitude spatially uniform magnetization excitations in an in-plane magnetized magnetic pillar with two ferromagnetic layers coupled by dipole-dipole interaction can be approximately described by the traditional Kittel formula with reduced saturation magnetization and effective anisotropy field. The spectrum consists of a quasi-symmetric and a quasi-antisymmetric mode, and the apparent reduction of saturation magnetization for the quasi-symmetric mode (<= 50%) is much larger than that for the quasi-antisymmetric mode (<= 10%). The effect of dynamic dipolar coupling between the nano-pillar layers could be partly responsible for the apparent reduction of static magnetization seen in many spin-torque experiments performed on magnetic nano-pillars. C1 [Dmytriiev, O.; Slavin, A.; Tiberkevich, V.] Oakland Univ, Dept Phys, Rochester, MI 48309 USA. [Dmytriiev, O.] Inst Magnetism, UA-142 Kiev, Ukraine. [Meitzler, T.; Bankowski, E.] USA, TARDEC, Warren, MI 48397 USA. RP Dmytriiev, O (reprint author), Oakland Univ, Dept Phys, Rochester, MI 48309 USA. EM slavin@oakland.edu; tyberkev@oakland.edu RI Tiberkevich, Vasil/A-8697-2008; Meitzler, Thomas/D-1065-2017 OI Tiberkevich, Vasil/0000-0002-8374-2565; FU National Science Foundation of the USA [ECCS 0653901]; US Army TARDEC, RDECOM [W56HZW-09-P-L564]; US Army Research Office (MURI) [W911NF-04-1-0247] FX We acknowledge support from the National Science Foundation of the USA (grant No. ECCS 0653901), from the US Army TARDEC, RDECOM (contract N0. W56HZW-09-P-L564), and from the US Army Research Office (MURI grant No. W911NF-04-1-0247). NR 13 TC 20 Z9 20 U1 0 U2 4 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0953-8984 J9 J PHYS-CONDENS MAT JI J. Phys.-Condes. Matter PD APR 7 PY 2010 VL 22 IS 13 AR 136001 DI 10.1088/0953-8984/22/13/136001 PG 6 WC Physics, Condensed Matter SC Physics GA 570MS UT WOS:000275683000017 PM 21389519 ER PT J AU Cureton, LT Beyer, FL Turner, SR AF Cureton, LaShonda T. Beyer, Frederick L. Turner, S. Richard TI Synthesis and characterization of hexafluoroisopropylidene bisphenol poly(arylene ether sulfone) and polydimethylsiloxane segmented block copolymers SO POLYMER LA English DT Article DE Poly(arylene ether sulfone); Segmented block copolymer; Morphology ID POLYURETHANE ELASTOMERS; MULTIBLOCK COPOLYMERS; MEMBRANES; MORPHOLOGY; POLYMERS; SERIES; POLYSTYRENE; STABILITY; CARBONATE; SURFACE AB A series of hexafluoroisopropylidene bisphenol poly(arylene ether sulfone) (BAF PAES) segmented block copolymers with varying fractions of polydimethylsiloxane (PDMS) were synthesized by a condensation reaction of hydroxyl-terminated BAF PAES and dimethylamino endcapped PDMS. The segmented block copolymers have high thermal stability. The BAF PAES homopolymer exhibits a tensile modulus of 1700 MPa and an elongation at break of 16%. Copolymerizing BAF PAES with increasing molecular weight amounts of PDMS results in tensile properties ranging from plastic to elastomeric where the elongation is 417% for a segmented block copolymer with 64 wt% PDMS incorporated. The morphological properties of these segmented block copolymers were characterized by atomic force microscopy (AFM), small-angle X-ray scattering (SAXS), and transmission electron microscopy (TEM). AFM and TEM images show the segmented block copolymers were microphase separated, and comparison with bisphenol A (BA) PAES-b-PDMS segmented block copolymers revealed complex differences between the morphological behavior of the two systems. SAXS data of the segmented block copolymers supports AFM and TEM images, indicating microphase separation but little long-range order. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Cureton, LaShonda T.; Turner, S. Richard] Virginia Polytech Inst & State Univ, Dept Chem Macromol & Interfaces Inst MII, Blacksburg, VA 24061 USA. [Beyer, Frederick L.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Turner, SR (reprint author), Virginia Polytech Inst & State Univ, Dept Chem Macromol & Interfaces Inst MII, Blacksburg, VA 24061 USA. EM srturner@vt.edu FU Army Research Laboratory [W911NF-06-2-0014] FX This research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-06-2-0014. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. NR 41 TC 9 Z9 11 U1 3 U2 12 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 J9 POLYMER JI Polymer PD APR 6 PY 2010 VL 51 IS 8 BP 1679 EP 1686 DI 10.1016/j.polymer.2010.02.010 PG 8 WC Polymer Science SC Polymer Science GA 580WR UT WOS:000276481800003 ER PT J AU Lee, I Choi, KK Gorsich, D AF Lee, Ikjin Choi, K. K. Gorsich, David TI Sensitivity analyses of FORM-based and DRM-based performance measure approach (PMA) for reliability-based design optimization (RBDO) SO INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING LA English DT Article DE sensitivity analyses; dimension reduction method (DRM); inverse reliability analysis; first-order reliability method (FORM); performance measure approach (PMA); most probable point (MPP) update; reliability-based design optimization (RBDO) ID DIMENSION-REDUCTION METHOD; MULTIDIMENSIONAL INTEGRATION; STOCHASTIC MECHANICS AB In gradient-based design optimization, the sensitivities of the constraint with respect to the design variables are required. In reliability-based design optimization (RBDO), the probabilistic constraint is evaluated at the most probable point (MPP), and thus the sensitivities of the probabilistic constraints at MPP are required. This paper presents the rigorous analytic derivation of the sensitivities of the probabilistic constraint at MPP for both first-order reliability method (FORM)-based performance measure approach (PMA) and dimension reduction method (DRM)-based PMA. Numerical examples are used to demonstrate that the analytic sensitivities agree very well with the sensitivities obtained from the finite difference method (FDM). However, as the sensitivity calculation at the true DRM-based MPP requires the second-order derivatives and additional MPP search, the sensitivity derivation at the approximated DRM-based MPP, which does not require the second-order derivatives and additional MPP search to find the DRM-based MPP, is proposed in this paper. A convergence study illustrates that the sensitivity at the approximated DRM-based MPP converges to the sensitivity at the true DRM-based MPP as the design approaches the optimum design. Hence, the sensitivity at the approximated DRM-based MPP is proposed to be used for the DRM-based RBDO to enhance the efficiency of the optimization. Copyright (C) 2009 John Wiley & Sons, Ltd. C1 [Lee, Ikjin; Choi, K. K.] Univ Iowa, Coll Engn, Dept Mech & Ind Engn, Iowa City, IA 52242 USA. [Gorsich, David] USA, RDECOM TARDEC, AMSRD TAR, Warren, MI 48397 USA. RP Choi, KK (reprint author), Univ Iowa, Coll Engn, Dept Mech & Ind Engn, Iowa City, IA 52242 USA. EM kkchoi@engineering.uiowa.edu RI Lee, IkJin/I-4722-2013; Choi, Kyung/B-1512-2008 OI Choi, Kyung/0000-0003-2384-6220 FU Automotive Research Center; U.S. Army TARDEC FX Research is supported by the Automotive Research Center, which is sponsored by the U.S. Army TARDEC. NR 34 TC 20 Z9 22 U1 0 U2 11 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 0029-5981 J9 INT J NUMER METH ENG JI Int. J. Numer. Methods Eng. PD APR 2 PY 2010 VL 82 IS 1 BP 26 EP 46 DI 10.1002/nme.2752 PG 21 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Mathematics GA 574EM UT WOS:000275971500002 ER PT J AU Behrens, DA Lee, IC Waits, CM AF Behrens, Douglas A. Lee, Ivan C. Waits, C. Michael TI Catalytic combustion of alcohols for microburner applications SO JOURNAL OF POWER SOURCES LA English DT Article DE Alcohols; Combustion; Microburner; Reforming; Electrospray; Bio-refinery ID PARTIAL OXIDATION; ETHANOL; FUEL; MESOSCALE; LIQUIDS AB The combustion of energy dense liquid fuels in a catalytic micro-combustor, whose temperatures can be used in energy conversion devices, is an attractive alternative to cumbersome batteries. To miniaturize the reactor, an evaporation model was developed to calculate the minimum distance required for complete droplet vaporization. By increasing the ambient temperature from 298 to 350 K, the distance required for complete evaporation of a 6.5 mu m droplet decreases from 3.5 to 0.15 cm. A platinum mesh acted as a preliminary measurement and demonstrated 75% conversion of ethanol. We then selected a more active rhodium-coated alumina foam with a larger surface area and attained 100% conversion of ethanol and 95% conversion of 1-butanol under fuel lean conditions. Effluent post-combustion gas analysis showed that varying the equivalence ratio results in three possible modes of operation. A regime of high carbon selectivity for CO(2) occurs at low equivalence ratios and corresponds to complete combustion with a typical temperature of 775 K that is ideal for PbTe thermoelectric energy conversion devices. Conversely for equivalence ratios greater than 1, carbon selectivity for CO(2) decreases as hydrogen, olefin and paraffin production increases. By tuning the equivalence ratio, we have shown that a single device can combust completely for thermoelectric applications, operate as a fuel reformer to produce hydrogen gas for fuel cells or perform as a bio-refinery for paraffin and olefin synthesis. Published by Elsevier B.V. C1 [Behrens, Douglas A.; Lee, Ivan C.; Waits, C. Michael] USA, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. RP Lee, IC (reprint author), USA, Res Lab, Sensors & Elect Devices Directorate, 2800 Powder Mill Road, Adelphi, MD 20783 USA. EM ilee@arl.army.mil RI Lee, Ivan/H-6444-2011 NR 18 TC 9 Z9 9 U1 0 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD APR 2 PY 2010 VL 195 IS 7 SI SI BP 2008 EP 2013 DI 10.1016/j.jpowsour.2009.10.001 PG 6 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 547JM UT WOS:000273883400037 ER PT J AU Hekman, DR Aquino, K Owens, BP Mitchell, TR Schilpzand, P Leavitt, K AF Hekman, David R. Aquino, Karl Owens, Bradley P. Mitchell, Terence R. Schilpzand, Pauline Leavitt, Keith TI AN EXAMINATION OF WHETHER AND HOW RACIAL AND GENDER BIASES INFLUENCE CUSTOMER SATISFACTION SO ACADEMY OF MANAGEMENT JOURNAL LA English DT Article ID IMPLICIT ASSOCIATION TEST; PATIENT-PHYSICIAN RELATIONSHIP; PERFORMANCE RATINGS; FINANCIAL PERFORMANCE; SHAREHOLDER VALUE; LABOR-MARKET; RACE; ATTITUDES; IMPACT; DISCRIMINATION AB We examined whether and how various biases may influence customers' satisfaction evaluations and produce discriminatory judgments for minority and female service employees. We argue that customer satisfaction evaluations are biased because they are anonymous judgments by untrained raters that usually lack an evaluation standard. Laboratory and field samples provide disturbing evidence generally confirming our arguments and suggesting that the presence of nonwhite and women service employees may produce lower aggregated customer satisfaction evaluations that may ultimately hurt individuals and organizations financially. C1 [Hekman, David R.] Univ Wisconsin Milwaukee, Lubar Sch Business, Milwaukee, WI 53201 USA. [Aquino, Karl] Univ British Columbia, Sauder Sch Business, Vancouver, BC V5Z 1M9, Canada. [Owens, Bradley P.] Univ Michigan, Ctr Posit Org Scholarship, Ann Arbor, MI 48109 USA. [Mitchell, Terence R.] Univ Washington, Seattle, WA 98195 USA. [Schilpzand, Pauline; Leavitt, Keith] US Mil Acad, West Point, PA USA. RP Hekman, DR (reprint author), Univ Wisconsin Milwaukee, Lubar Sch Business, Milwaukee, WI 53201 USA. EM hekman@uwm.edu; karl.aquino@sauder.ubc.ca; bpowens@bus.umich.edu; trm@u.washington.edu; pauline.schilpzand@usma.edu; keith.leavitt@usma.edu RI Leavitt, Keith/D-6686-2012 OI Leavitt, Keith/0000-0003-3729-3997 NR 107 TC 39 Z9 39 U1 6 U2 42 PU ACAD MANAGEMENT PI BRIARCLIFF MANOR PA PACE UNIV, PO BOX 3020, 235 ELM RD, BRIARCLIFF MANOR, NY 10510-8020 USA SN 0001-4273 EI 1948-0989 J9 ACAD MANAGE J JI Acad. Manage. J. PD APR PY 2010 VL 53 IS 2 BP 238 EP 264 DI 10.5465/AMJ.2010.49388763 PG 27 WC Business; Management SC Business & Economics GA 596BC UT WOS:000277657300003 ER PT J AU Peterson, AM Jensen, RE Palmese, GR AF Peterson, Amy M. Jensen, Robert E. Palmese, Giuseppe R. TI Room-Temperature Healing of a Thermosetting Polymer Using the Diels-Alder Reaction SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE biomimetic; Diels-Alder polymers; functionalization of polymers; stimuli-sensitive polymers ID FIBER-REINFORCED POLYMER; EPOXY-AMINE THERMOSETS; SILICA; COMPOSITES; COPOLYMERS; MALEIMIDE; BEHAVIOR; AGENTS; RESINS AB Self-healing materials are particularly desirable for load-bearing applications because they offer the potential For increased safety and material lifetimes. A furan-functionalized polymer network was designed that can heal via covalent bonding across the crack surface with the use of a healing agent consisting of a bismaleimide in solution. Average healing efficiencies of approximately 70% were observed. The healing ability of fiber-reinforced composite specimens was investigated with flexural, short beam shear, and double cantilever beam specimens. It was found that solvent amount and maleimide concentration play key roles in determining healing efficiency. C1 [Peterson, Amy M.; Palmese, Giuseppe R.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. [Jensen, Robert E.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Palmese, GR (reprint author), Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. EM palmese@coe.drexel.edu RI Peterson, Amy/A-2945-2012 OI Peterson, Amy/0000-0002-4612-0062 FU U.S. Army Research Laboratory [W911NF-06-2-0013]; National Science Foundation; University of Pennsylvania [DGE-0654313]; Graduate Research Fellowship Program FX The authors wish to acknowledge the U.S. Army Research Laboratory for financial support under the Army Materials Center of Excellence Program, contract W911NF-06-2-0013. Financial support for Amy M. Peterson was provided by the National Science Foundation under the Integrated Graduate Education and Research Traineeship in Nanoscale Science and Engineering administered by Drexel University and the University of Pennsylvania, Contract DGE-0654313. as well as the Graduate Research Fellowship Program. The authors also thank Claude Robotham and Joseph Dorsheimer of Thermo Fisher Scientific for DCB specimen surface analysis. NR 37 TC 83 Z9 85 U1 7 U2 98 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD APR PY 2010 VL 2 IS 4 BP 1141 EP 1149 DI 10.1021/am9009378 PG 9 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA 588BT UT WOS:000277042000031 PM 20423133 ER PT J AU Gerard, BF AF Gerard, Brian F. TI Anisotropy and Voiding at High Strain Rates in a Mg Alloy Extrudate SO ADVANCED MATERIALS & PROCESSES LA English DT Article C1 [Gerard, Brian F.] Lehigh Univ, Bethlehem, PA 18015 USA. RP Gerard, BF (reprint author), USA, Picatinny Arsenal, NJ USA. EM brian.f.gerard@us.army.mil NR 0 TC 3 Z9 3 U1 0 U2 1 PU ASM INT PI MATERIALS PARK PA SUBSCRIPTIONS SPECIALIST CUSTOMER SERVICE, MATERIALS PARK, OH 44073-0002 USA SN 0882-7958 J9 ADV MATER PROCESS JI Adv. Mater. Process. PD APR PY 2010 VL 168 IS 4 BP 32 EP 33 PG 2 WC Materials Science, Multidisciplinary SC Materials Science GA 582XH UT WOS:000276633300006 ER PT J AU Nie, JH Hopkins, DA Chen, YT Hsieh, HT AF Nie, J. H. Hopkins, D. A. Chen, Y. T. Hsieh, H. T. TI Development of an object-oriented finite element program with adaptive mesh refinement for multi-physics applications SO ADVANCES IN ENGINEERING SOFTWARE LA English DT Article DE Computer engineering application; Numerical modeling; Software development ID PARTIAL-DIFFERENTIAL EQUATIONS; ERROR ESTIMATION; COMPUTATIONS AB In this paper, an object-oriented framework for numerical analysis of multi-physics applications is presented. The framework is divided into several basic sets of classes that enable the code segments to be built according to the type of problem to be solved. Fortran 2003 was used in the development of this finite element program due to its advantages for scientific and engineering programming and its new object-oriented features. The program was developed with h-type adaptive mesh refinement, and it was tested for several classical cases involving heat transfer, fluid mechanics and structural mechanics. The test cases show that the adaptive mesh is refined only in the localization region where the feature gradient is relatively high. The overall mesh refinement and the h-adaptive mesh refinement were justified with respect to the computational accuracy and the CPU time cost. Both methods can improve the computational accuracy with the refinement of mesh. The overall mesh refinement causes the CPU time cost to greatly increase as the mesh is refined. However, the CPU time cost does not increase very much with the increase of the level of h-adaptive mesh refinement. The CPU time cost can be saved by up to 90%, especially for the simulated system with a large number of elements and nodes. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Nie, J. H.; Chen, Y. T.; Hsieh, H. T.] Univ Nevada, Dept Mech Engn, Las Vegas, NV 89154 USA. [Hopkins, D. A.] USA, Res Lab, Weapon & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Nie, JH (reprint author), Univ Nevada, Dept Mech Engn, Las Vegas, NV 89154 USA. EM jianhu@nscee.edu FU US Department of Defense (Army Research Office) [DAAD 19-03-2-0007] FX The authors gratefully acknowledge the financial support by the US Department of Defense (Army Research Office) under Grant No. DAAD 19-03-2-0007. NR 49 TC 5 Z9 5 U1 0 U2 9 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0965-9978 J9 ADV ENG SOFTW JI Adv. Eng. Softw. PD APR PY 2010 VL 41 IS 4 BP 569 EP 579 DI 10.1016/j.advengsoft.2009.11.004 PG 11 WC Computer Science, Interdisciplinary Applications; Computer Science, Software Engineering; Engineering, Multidisciplinary SC Computer Science; Engineering GA 571ON UT WOS:000275763700007 ER PT J AU Muramatsu, RS Litzinger, MHJ Fisher, E Takeshita, J AF Muramatsu, Russ S. Litzinger, Mark H. J. Fisher, Ed Takeshita, Junji TI Alternative Formulations, Delivery Methods, and Administration Options for Psychotropic Medications in Elderly Patients With Behavioral and Psychological Symptoms of Dementia SO AMERICAN JOURNAL OF GERIATRIC PHARMACOTHERAPY LA English DT Review DE BPSD; medication delivery; alternative medication formulations; psychotropic medicine use in elderly ID ENTERAL FEEDING TUBES; ATYPICAL ANTIPSYCHOTIC MEDICATIONS; NURSING-HOME PLACEMENT; ALZHEIMERS-DISEASE; NEUROPSYCHIATRIC SYMPTOMS; PSYCHIATRIC MEDICATIONS; INTRAVENOUS VALPROATE; COVERT MEDICATION; LATE PARAPHRENIA; DRUG-THERAPY AB Objective: The purpose of this paper was to review alternative formulations, delivery methods, and administration options for psychotropic medications in elderly patients with behavioral and psychological symptoms of dementia (BPSD). Methods: A MEDLINE search was conducted initially in December 2008 and was updated in September 2009, including the search terms pharmacologic treatment and dementia, behavioral and psychological symptoms of dementia, alternative psychotropic medication formulations, alternative dosing methods of medication, drug delivery options, antidepressants and dementia, anxiolytics and dementia, antipsychotics and dementia, mood stabilizers and dementia, cognitive enhancers and dementia, medications and enteral feeding tubes, and hiding medication. Studies were limited to English-language articles dated from 1950 to 2009. Additional relevant articles were obtained by reviewing the references in the initial articles. Drug Facts and Comparisons 4.0 Online, Lexi-Comp Online, and Lexi-Drugs Online were used to obtain additional information. Targeted patients were elderly individuals with BPSD who were considered difficult to treat because they were unable to swallow, were refusing medications, or were not able to eat or drink per physician order. Results: In addition to the standard capsule or tablet given orally, a variety of formulations and delivery methods for psychotropic medications are available. Options include short- and long-acting intramuscular, intravenous, liquid, orally disintegrating, transdermal patch, sublingual, and rectal forms. Additionally, all formulations can be further altered in substance, delivery, or both. For example, tablets may be crushed and capsules opened; this changes their formulation and allows the option of mixing with food or liquids to be taken by mouth or through a tube. Caution must be used, however; in certain cases, alteration of the original form or the intended delivery method is contraindicated. In addition, many alternative administration options are not formally approved for use in the manner in which they are commonly applied and are therefore used with little or no information on tolerability and effectiveness. Ethical and legal issues include patient consent and off-label use. Conclusions: Overall, few studies have examined the use and efficacy of alternative psychotropic formulations and delivery methods in elderly patients with BPSD, and none have specifically addressed drug-alteration and alternative-administration issues. There is no evidence to compare alternative delivery forms (eg, tablet or capsule) of a given medication in terms of efficacy or tolerability. Still, alternative methods may be the only option for treatment of some patients. Practitioners must be familiar with the range of formulations and delivery options available so that they can optimize their patients' medication regimens. More data are needed on the use of alternative formulations, delivery methods, and administration options and their limitations in this population. (Am J Geriatr Pharmacother. 2010;8:98-114) (C) 2010 Excerpta Medica Inc. C1 [Muramatsu, Russ S.] Tripler Army Med Ctr, Dept Psychiat, Honolulu, HI 96859 USA. [Litzinger, Mark H. J.] Philadelphia Coll Osteopath Med Georgia, Sch Pharm, Suwanee, GA USA. [Fisher, Ed] Univ Hawaii, Coll Pharm, Hilo, HI 96720 USA. [Takeshita, Junji] Univ Hawaii, John A Burns Sch Med, Dept Psychiat, Honolulu, HI 96822 USA. RP Muramatsu, RS (reprint author), Tripler Army Med Ctr, Dept Psychiat, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM russ.muramatsu@amedd.army.mil FU Department of Psychiatry, Tripler Army Medical Center (TAMC), Honolulu, Hawaii FX This study was funded by the Department of Psychiatry, Tripler Army Medical Center (TAMC), Honolulu, Hawaii. The views expressed in this manuscript are those of the authors and do not reflect the official policy or position of the TAMC Department of Psychiatry, Department of the Army, Department of Defense, or the US Government. The authors have indicated that they have no other conflicts of interest regarding the content of this article. NR 85 TC 9 Z9 9 U1 3 U2 24 PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC PI BRIDGEWATER PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA SN 1543-5946 J9 AM J GERIATR PHARMAC JI Am. J. Geriatr. Pharmacother. PD APR PY 2010 VL 8 IS 2 BP 98 EP 114 DI 10.1016/j.amjopharm.2010.03.003 PG 17 WC Geriatrics & Gerontology; Pharmacology & Pharmacy SC Geriatrics & Gerontology; Pharmacology & Pharmacy GA 589NQ UT WOS:000277157400001 PM 20439060 ER PT J AU Kraft, M Amick, MM Barth, JT French, LM Lew, HL AF Kraft, Malissa Amick, Melissa M. Barth, Jeffrey T. French, Louis M. Lew, Henry L. TI A Review of Driving Simulator Parameters Relevant to the Operation Enduring Freedom/Operation Iraqi Freedom Veteran Population SO AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION LA English DT Review DE Brain Injury; Driving; Virtual Reality; Posttraumatic Stress Disorder ID TRAUMATIC BRAIN-INJURY; OBSTRUCTIVE SLEEP-APNEA; POSTTRAUMATIC-STRESS-DISORDER; ALZHEIMER-DISEASE; WAKEFULNESS TEST; MEDICAL FITNESS; PERSIAN-GULF; PERFORMANCE; ALCOHOL; US AB Kraft M, Amick MM, Barth JT, French LM, Lew HL: A review of driving simulator parameters relevant to the Operation Enduring Freedom/Operation Iraqi Freedom veteran population. Am J Phys Med Rehabil 2010;89:336-344. There is currently a pressing need for safe, reliable, cost-effective methods of evaluating driving ability. With recent improvements in virtual reality technology, driving simulators seem to offer a promising alternative to on-road methods of driving assessment. One population at risk for driving difficulties may be veterans returning from combat in Iraq or Afghanistan. The use of driving simulators to evaluate and remediate veterans' abilities to operate a motor vehicle is a rehabilitative goal. However, there are no consistent standardized procedures for determining safe from unsafe driving using driving simulators, which limit the clinical utility of this important tool. The purposes of this article are (1) to give the reader a better understanding of the parameters that are most commonly measured in the driving simulation literature and (2) to review parameters that are most relevant for the Operation Enduring Freedom/Operation Iraqi Freedom veteran population. C1 [Lew, Henry L.] VA Boston Hlth Care Syst, PM&R Serv, Dept Vet Affairs, Boston, MA 02130 USA. [Kraft, Malissa; Amick, Melissa M.; Lew, Henry L.] VA Boston Healthcare Syst, Polytrauma & Traumat Brain Injury Ctr, Boston, MA USA. [Lew, Henry L.] Harvard Univ, Sch Med, Dept Phys Med & Rehabil, Boston, MA USA. [Barth, Jeffrey T.; Lew, Henry L.] Virginia Neurocare, Def & Vet Brain Injury Ctr, Charlottesville, VA USA. [Barth, Jeffrey T.] Lakeview Healthcare Syst, Charlottesville, VA USA. [Barth, Jeffrey T.] Univ Virginia, Sch Med, Div Neuropsychol, Charlottesville, VA 22908 USA. [French, Louis M.] Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20307 USA. [French, Louis M.] Walter Reed Army Med Ctr, Dept Orthoped & Rehabil, Washington, DC 20307 USA. [French, Louis M.] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. RP Lew, HL (reprint author), VA Boston Hlth Care Syst, PM&R Serv, Dept Vet Affairs, 150 S Huntington Ave, Boston, MA 02130 USA. NR 69 TC 12 Z9 12 U1 2 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0894-9115 J9 AM J PHYS MED REHAB JI Am. J. Phys. Med. Rehabil. PD APR PY 2010 VL 89 IS 4 BP 336 EP 344 DI 10.1097/PHM.0b013e3181d3eb5f PG 9 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 584CA UT WOS:000276726400009 PM 20299851 ER PT J AU Forman, HP Javitt, MC Monsees, B Crowe, JK Beauchamp, NJ Larson, DB Kaye, A Kazerooni, EA Norbash, A Messinger, N Hricak, H Thrall, JH AF Forman, Howard P. Javitt, Marcia C. Monsees, Barbara Crowe, John K. Beauchamp, Norman J., Jr. Larson, David B. Kaye, Alan Kazerooni, Ella A. Norbash, Alexander Messinger, Neil Hricak, Hedvig Thrall, James H. TI Masters of Radiology Panel Discussion: Role of Communication in Today's Radiologic Practices SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Editorial Material DE communications; critical reports; MQSA; technology C1 [Forman, Howard P.] Yale Univ, MBA Program, New Haven, CT 06520 USA. [Forman, Howard P.] Yale Univ, MBA Execut, New Haven, CT USA. [Javitt, Marcia C.] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. [Monsees, Barbara] Washington Univ, Med Ctr, Mallinckrodt Inst Radiol, Breast Imaging Sect, St Louis, MO 63110 USA. [Crowe, John K.] Scottsdale Med Imaging, Scottsdale, AZ USA. [Beauchamp, Norman J., Jr.] Univ Washington, Dept Radiol, Seattle, WA 98195 USA. [Larson, David B.] Cincinnati Childrens Hosp, Med Ctr, Dept Radiol, Cincinnati, OH USA. [Kaye, Alan] Bridgeport Hosp, Dept Radiol, Westport, CT USA. [Kazerooni, Ella A.] Univ Michigan Hosp, Dept Radiol, Ann Arbor, MI 48109 USA. [Norbash, Alexander] Boston Univ, Med Ctr, Dept Radiol, Boston, MA 02118 USA. [Messinger, Neil] Baptist Hlth Syst, Dept Radiol, Miami, FL USA. [Hricak, Hedvig] Mem Sloan Kettering Canc Ctr, Dept Radiol, Seattle, WA USA. [Thrall, James H.] Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA. RP Forman, HP (reprint author), Yale Univ, MBA Program, New Haven, CT 06520 USA. EM howard.forman@yale.edu OI Norbash, Alexander/0000-0003-2986-2563; Hricak, Hedvig/0000-0003-2240-9694 NR 0 TC 3 Z9 3 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD APR PY 2010 VL 194 IS 4 BP 1014 EP 1017 DI 10.2214/AJR.09.4060 PG 4 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 572VX UT WOS:000275863300023 PM 20308504 ER PT J AU Waterman, BR Belmont, PJ Cameron, KL DeBerardino, TM Owens, BD AF Waterman, Brian R. Belmont, Philip J., Jr. Cameron, Kenneth L. DeBerardino, Thomas M. Owens, Brett D. TI Epidemiology of Ankle Sprain at the United States Military Academy SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE ankle; sprain; epidemiology; risk factor; military ID CRUCIATE LIGAMENT INJURY; EXERCISE-RELATED INJURIES; INTRINSIC RISK-FACTORS; FEMALE ARMY TRAINEES; HIGH-SCHOOL SPORTS; LATERAL ANKLE; SYNDESMOSIS SPRAINS; ATHLETIC POPULATION; BASKETBALL PLAYERS; SOCCER INJURIES AB Background: Ankle sprain is a common injury in athletic populations that results in significant time lost to injury. Hypothesis: The incidence rates (IRs) of ankle ligament sprains are influenced by gender, height, weight, body mass index (BMI), physical conditioning, level of competition, type of sport, and athlete exposure to sport. Study Design: Cohort study; Level of evidence, 2. Methods: A longitudinal cohort study was performed to determine the effect of risk factors for ankle sprain at the United States Military Academy between 2005 and 2007. Results: A total 614 cadets sustained new ankle sprains during 10511 person-years at risk, resulting in an overall IR of 58.4 per 1000 person-years. Women (96.4), compared with men (52.7), had a significantly increased rate ratio (IRR) for ankle sprain of 1.83 (95% confidence interval [CI], 1.52-2.20). Men with ankle sprains had higher mean height, weight, and BMI than uninjured men (P < .001). Men with ankle sprains had higher average scores in push-ups, sit-ups, and run time than uninjured men (P < .001). Ankle sprain occurred most commonly during athletics (64.1%). Ankle sprain IR did not significantly differ between intercollegiate and intramural athletic competition after controlling for athlete-exposure (IRR, 1.05; 95% CI, 0.81-1.37). The ankle sprain IRR of female compared with male intercollegiate athletes was 0.93 (95% CI, 0.67-1.32) per 1000 person-years and 1.04 (95% CI, 0.74-1.47) per 1000 athlete-exposures. The intercollegiate sports of men's rugby, women's cheerleading, and men's/women's basketball, soccer, and lacrosse had the highest ankle sprain IR. Conclusion: Higher mean height and weight in men, increased BMI in men, greater physical conditioning in men, and athlete exposure to selected sports were all risk factors for ankle sprain. C1 [Owens, Brett D.] US Mil Acad, Orthopaed Surg Serv, Keller Army Hosp, West Point, NY 10996 USA. [Waterman, Brian R.; Belmont, Philip J., Jr.] William Beaumont Army Med Ctr, El Paso, TX 79920 USA. [DeBerardino, Thomas M.] Univ Connecticut, Ctr Hlth, Farmington, CT USA. RP Waterman, BR (reprint author), US Mil Acad, Orthopaed Surg Serv, Keller Army Hosp, West Point, NY 10996 USA. EM b.owens@us.army.mil OI DeBerardino, Thomas/0000-0002-7110-8743; Belmont, Philip/0000-0003-2618-199X; Cameron, Kenneth/0000-0002-6276-4482 NR 62 TC 50 Z9 52 U1 5 U2 16 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD APR PY 2010 VL 38 IS 4 BP 979 EP 803 DI 10.1177/0363546509350757 PG 7 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 576RZ UT WOS:000276167200019 PM 20145281 ER PT J AU Lee, JJ Hurst, FP Abbott, KC Agodoa, LY Jindal, RM AF Lee, Jessica J. Hurst, Frank P. Abbott, Kevin C. Agodoa, Lawrence Y. Jindal, Rahul M. TI Outcomes Associated with Influenza Vaccination in the First Year after Kidney Transplantation: Analysis of USRDS SO AMERICAN JOURNAL OF TRANSPLANTATION LA English DT Meeting Abstract CT 10th American Transplant Congress CY MAY 01-05, 2010 CL San Diego, CA SP Amer Soc Transplantat C1 [Lee, Jessica J.; Hurst, Frank P.; Abbott, Kevin C.; Jindal, Rahul M.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Agodoa, Lawrence Y.] NIDDK, NIH, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1600-6135 J9 AM J TRANSPLANT JI Am. J. Transplant. PD APR PY 2010 VL 10 SU 4 SI SI BP 127 EP 127 PG 1 WC Surgery; Transplantation SC Surgery; Transplantation GA 573NX UT WOS:000275921701292 ER PT J AU Hurst, FP Sajjad, I Elster, EA Falta, EM Agodoa, LY Abbott, KC Jindal, RM AF Hurst, Frank P. Sajjad, Imran Elster, Eric A. Falta, Edward M. Agodoa, Lawrence Y. Abbott, Kevin C. Jindal, Rahul M. TI Transplantation of A2 Kidneys into B and O Recipients: USRDS Experience. SO AMERICAN JOURNAL OF TRANSPLANTATION LA English DT Meeting Abstract CT 10th American Transplant Congress CY MAY 01-05, 2010 CL San Diego, CA SP Amer Soc Transplantat C1 [Hurst, Frank P.; Elster, Eric A.; Falta, Edward M.; Abbott, Kevin C.; Jindal, Rahul M.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Sajjad, Imran] Univ Wisconsin, Madison, WI USA. [Agodoa, Lawrence Y.] NIDDK, Natl Inst Hlth, Bethesda, MD USA. [Jindal, Rahul M.] George Washington Univ, Med Ctr, Washington, DC 20037 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1600-6135 J9 AM J TRANSPLANT JI Am. J. Transplant. PD APR PY 2010 VL 10 SU 4 SI SI BP 282 EP 282 PG 1 WC Surgery; Transplantation SC Surgery; Transplantation GA 573NX UT WOS:000275921702254 ER PT J AU Stevens, K Phinney, S Graybill, C Gillern, S Salifu, MO Jindal, RM Brown, TS Elster, EA AF Stevens, Kristin Phinney, Samuel Graybill, Christopher Gillern, Suzanne Salifu, Moro O. Jindal, Rahul M. Brown, Trevor S. Elster, Eric A. TI Bayesian Modeling of the United States Renal Data System Pre-Transplant Variables Accurately Predicts Graft Survival SO AMERICAN JOURNAL OF TRANSPLANTATION LA English DT Meeting Abstract CT 10th American Transplant Congress CY MAY 01-05, 2010 CL San Diego, CA SP Amer Soc Transplantat C1 [Stevens, Kristin; Phinney, Samuel; Graybill, Christopher; Gillern, Suzanne; Brown, Trevor S.; Elster, Eric A.] USN, Med Res Ctr, Silver Spring, MD USA. [Salifu, Moro O.] Suny Downstate Med Ctr, Transplant Program, Brooklyn, NY 11203 USA. [Phinney, Samuel; Graybill, Christopher; Gillern, Suzanne; Jindal, Rahul M.] Walter Reed Army Med Ctr, Transplant Program, Washington, DC 20307 USA. [Stevens, Kristin] USN, San Diego Med Ctr, Dept Surg, San Diego, CA 92152 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1600-6135 J9 AM J TRANSPLANT JI Am. J. Transplant. PD APR PY 2010 VL 10 SU 4 SI SI BP 369 EP 369 PG 1 WC Surgery; Transplantation SC Surgery; Transplantation GA 573NX UT WOS:000275921702567 ER PT J AU Nam, DH Oh, JS Nam, MH Park, HC Lim, CS Lee, WJ Sattabongkot, J Klein, TA Ayala, FJ AF Nam, Deok Hwa Oh, Jun Seo Nam, Myoung Hyun Park, Hae Chul Lim, Chae Seung Lee, Won Ja Sattabongkot, Jetsumon Klein, Terry A. Ayala, Francisco J. TI Short Report: Emergence of New Alleles of the MSP-3 alpha Gene in Plasmodium vivax Isolates from Korea SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID MEROZOITE SURFACE PROTEIN-3-ALPHA; DIVERSITY; MALARIA; POLYMORPHISM; INFECTIONS AB Nucleotide sequence analysis of the Plasmodium vivax PvMSP-3 alpha gene was conducted on blood from 143 malaria patients admitted to Korea University Medical Center from 1996 to 2007 in the Republic of Korea (ROK). From 1996 to 2002, the PvMSP-3 alpha alleles were of two types, SKOR-67 (2.53 kb) and SKOR-69 (1.78 kb), which differed in length and amino acid sequence. Two new variants with similar size to SKOR-67 were first observed in 2002 and in 2006-2007 accounted for nearly 50% (25/51) of the sampled isolates. The new variants had the same amino acid sequence as SKOR-69 in the N-terminal region, but in Blocks I and II and in the C-terminal region, they were similar to previously reported isolates from Thailand, Papua New Guinea, India, Brazil, and Ecuador strains. C1 [Nam, Deok Hwa; Nam, Myoung Hyun; Lim, Chae Seung] Korea Univ, Coll Med, Brain Korea Grad Sch Med 21, Dept Lab Med, Seoul 136705, South Korea. [Oh, Jun Seo] Korea Univ, Coll Med, Brain Korea Grad Sch Med 21, Cellular Oncol Lab, Seoul 136705, South Korea. [Lee, Won Ja] Minist Hlth & Welf, Korean Ctr Dis Control & Prevent, Lab Med Entomol, Seoul, South Korea. [Sattabongkot, Jetsumon] US Army Mil Component, Armed Forces Inst Med Sci, Dept Entomol, Bangkok, Thailand. [Klein, Terry A.] 65th Med Brigade, Force Hlth Protect, Unit 15281, Seoul, South Korea. [Ayala, Francisco J.] Univ Calif Irvine, Dept Ecol & Evolutionary Biol, Irvine, CA 92717 USA. [Park, Hae Chul] Korea Univ, Coll Med, Brain Korea Grad Sch Med 21, Lab Neurodev, Seoul 136705, South Korea. RP Lim, CS (reprint author), Korea Univ, Ansan Hosp, Coll Med, Dept Lab Med, 516 Gojan Dong, Ansan 425707, Gyoenggi Prov, South Korea. EM malarim@korea.ac.kr RI Valle, Ruben/A-7512-2013 NR 9 TC 5 Z9 6 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 2010 VL 82 IS 4 BP 522 EP 524 DI 10.4269/ajtmh.2010.08-0332 PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 577JR UT WOS:000276219700003 PM 20348492 ER PT J AU Kolodzinski, JJ Tannenbaum, LV Muller, LI Osborn, DA Adams, KA Conner, MC Ford, WM Miller, KV AF Kolodzinski, Jeffrey J. Tannenbaum, Lawrence V. Muller, Lisa I. Osborn, David A. Adams, Kent A. Conner, Mark C. Ford, W. Mark Miller, Karl V. TI Excursive Behaviors by Female White-tailed Deer during Estrus at Two Mid-Atlantic Sites SO AMERICAN MIDLAND NATURALIST LA English DT Article AB Current research suggests that female white-tailed deer (Odocoileus virginianus) will adopt sedentary breeding strategies in populations with an abundance of males and a more active mate-searching strategy in low-density or unbalanced herds. We used GPS collars to document, the movements of 10 female deer during the breeding season at two Mid-Atlantic study sites that support high-density herds with nearly equal sex ratios. We calculated 95% and 50% seasonal and weekly kernel home ranges and the daily percentage of points located outside of the seasonal home range (SHR). Peaks in weekly home range size and in the percentage of points located outside of the SHR occurred between 7 Nov. and 9 Dec. ((x) over bar = 22 Nov.) for eight deer. Past data from one of the study sites have indicated that most breeding activity occurs from 5-25 Nov. Peaks in the percentage of points outside of the SHR corresponded to brief ((x) over bar = 24.0 h, SD = 18.2 h; range 8-68 h) excursions. On peak days, 46-100% ((x) over bar = 68.3%, SD = 17.1%) of data points were located outside of the SHR. No other excursions were observed during the 17 wk study period. Our results suggest that female deer may travel outside of their home range during the breeding season even when presented with an abundance of potential mates; these data suggest females are engaging in a discrete form of mate selection. C1 [Kolodzinski, Jeffrey J.; Osborn, David A.; Miller, Karl V.] Univ Georgia, DB Warnell Sch Forestry & Nat Resources, Athens, GA 30602 USA. [Ford, W. Mark] USA, Ecol Resources Branch, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Conner, Mark C.] DuPont Agr Enterprise, Chesapeake Farms, Chestertown, MD 21620 USA. [Adams, Kent A.] Natl Wild Turkey Federat, Effingham, IL 62401 USA. [Muller, Lisa I.] Univ Tennessee, Dept Forestry Wildlife & Fisheries, Knoxville, TN 37996 USA. [Tannenbaum, Lawrence V.] USA, Ctr Hlth Promot & Prevent Med, MCHB TS REH, Aberdeen Proving Ground, MD 21010 USA. RP Miller, KV (reprint author), Univ Georgia, DB Warnell Sch Forestry & Nat Resources, Athens, GA 30602 USA. EM kmiller@warnell.uga.edu OI Muller, Lisa/0000-0001-7833-2273 FU Department of Defense; U.S. Army Environmental Command; U.S. Forest Service; Northern Research Station; University of Tennessee FX We thank the Department of Defense, U.S. Army Environmental Command, the U.S. Forest Service, Northern Research Station and the University of Tennessee for funding this research. Chesapeake Farms and Delaware Wild Lands Inc. graciously allowed us to conduct this study on their properties and provided welcomed logistical support. We thank Ralph Fleege, Ron Haas, Vanessa Lane and Family, Dustin Rutledge, Jenny Petersen, and Blake Fountain for field assistance and Michael T. Sense and the Delaware Department of Agriculture for the use of a dart rifle. NR 17 TC 10 Z9 11 U1 2 U2 13 PU AMER MIDLAND NATURALIST PI NOTRE DAME PA UNIV NOTRE DAME, BOX 369, ROOM 295 GLSC, NOTRE DAME, IN 46556 USA SN 0003-0031 EI 1938-4238 J9 AM MIDL NAT JI Am. Midl. Nat. PD APR PY 2010 VL 163 IS 2 BP 366 EP 373 DI 10.1674/0003-0031-163.2.366 PG 8 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 575ET UT WOS:000276050400010 ER PT J AU Darling, MJ Bryant, SD Kunz, AN Weisse, ME AF Darling, Matthew J. Bryant, Summer D. Kunz, Anjali N. Weisse, Martin E. TI Necrobacillosis: A case report of complicated Fusobacterium necrophorum septicemia SO ANAEROBE LA English DT Article DE Necrobacillosis; Lemierre's syndrome; Fusobacterium necrophorum ID LEMIERRES-SYNDROME; THROMBOPHLEBITIS; PHARYNGITIS; INFECTION; CHILDREN AB Necrobacillosis due to Fusobacterium necrophorum is an uncommon anaerobic infection. It has a wide range of presentations and commonly presents as Lemierre's syndrome. We present a case of necrobacillosis defined by F. necrophorum bacteremia with epidural and pararectal fluid collection without evidence of internal jugular vein thrombophlebitis. Published by Elsevier Ltd. C1 [Darling, Matthew J.; Bryant, Summer D.; Kunz, Anjali N.; Weisse, Martin E.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Darling, MJ (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM matt.darling@nccpeds.com NR 14 TC 1 Z9 1 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1075-9964 J9 ANAEROBE JI Anaerobe PD APR PY 2010 VL 16 IS 2 BP 171 EP 173 DI 10.1016/j.anaerobe.2009.05.005 PG 3 WC Microbiology SC Microbiology GA 597CW UT WOS:000277734600017 PM 19501182 ER PT J AU Maier, RM Palmer, MW Andersen, GL Halonen, MJ Josephson, KC Maier, RS Martinez, FD Neilson, JW Stern, DA Vercelli, D Wright, AL AF Maier, Raina M. Palmer, Michael W. Andersen, Gary L. Halonen, Marilyn J. Josephson, Karen C. Maier, Robert S. Martinez, Fernando D. Neilson, Julia W. Stern, Debra A. Vercelli, Donata Wright, Anne L. TI Environmental Determinants of and Impact on Childhood Asthma by the Bacterial Community in Household Dust SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID GRADIENT GEL-ELECTROPHORESIS; CANONICAL CORRESPONDENCE-ANALYSIS; 16S RIBOSOMAL-RNA; EARLY-LIFE; YOUNG-CHILDREN; EXPOSURE; RISK; POPULATIONS; ENDOTOXIN; AGE AB Asthma increased dramatically in the last decades of the 20th century and is representative of chronic diseases that have been linked to altered microbial exposure and immune responses. Here we evaluate the effects of environmental exposures typically associated with asthma protection or risk on the microbial community structure of household dust ( dogs, cats, and day care). PCR-denaturing gradient gel analysis (PCR-DGGE) demonstrated that the bacterial community structure in house dust is significantly impacted by the presence of dogs or cats in the home (P = 0.0190 and 0.0029, respectively) and by whether or not children attend day care (P = 0.0037). In addition, significant differences in the dust bacterial community were associated with asthma outcomes in young children, including wheezing (P = 0.0103) and specific IgE (P = 0.0184). Our findings suggest that specific bacterial populations within the community are associated with either risk or protection from asthma. C1 [Maier, Raina M.; Josephson, Karen C.; Neilson, Julia W.] Univ Arizona, Dept Soil Water & Environm Sci, Tucson, AZ 85721 USA. [Vercelli, Donata] Univ Arizona, Dept Cell Biol & Anat, Tucson, AZ 85721 USA. [Martinez, Fernando D.; Wright, Anne L.] Univ Arizona, Dept Pediat, Tucson, AZ 85721 USA. [Halonen, Marilyn J.] Univ Arizona, Dept Pharmacol, Tucson, AZ 85721 USA. [Halonen, Marilyn J.; Martinez, Fernando D.; Stern, Debra A.; Vercelli, Donata; Wright, Anne L.] Univ Arizona, Arizona Resp Ctr, Tucson, AZ 85721 USA. [Palmer, Michael W.] Oklahoma State Univ, Dept Bot, Stillwater, OK 74078 USA. [Andersen, Gary L.] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Earth Sci, Berkeley, CA 94720 USA. [Maier, Robert S.] USA, Engineer Res & Dev Ctr, Vicksburg, MS USA. RP Maier, RM (reprint author), Univ Arizona, Dept Soil Water & Environm Sci, 429 Shantz Bldg 38, Tucson, AZ 85721 USA. EM rmaier@ag.arizona.edu RI Palmer, Michael/A-2519-2008; Andersen, Gary/G-2792-2015 OI Andersen, Gary/0000-0002-1618-9827 FU NIAID NIH HHS [AI61811, R01 AI042268, AI 42268, R01 AI061811] NR 29 TC 30 Z9 31 U1 0 U2 10 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD APR PY 2010 VL 76 IS 8 BP 2663 EP 2667 DI 10.1128/AEM.01665-09 PG 5 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 578FX UT WOS:000276280100036 PM 20154107 ER PT J AU Nersisyan, SR Tabiryan, NV Steeves, DM Kimball, BR Chigrinov, VG Kwok, HS AF Nersisyan, Sarik R. Tabiryan, Nelson V. Steeves, Diane M. Kimball, Brian R. Chigrinov, Vladimir G. Kwok, Hoi Sing TI Study of azo dye surface command photoalignment material for photonics applications SO APPLIED OPTICS LA English DT Article ID POLARIZATION CONVERTERS; ALIGNING LAYERS; LIQUID-CRYSTALS; GENERATION; LIGHT AB We provide detailed quantitative characterization of sulfonic bisazodye SD1 as a photoalignment material for photonics applications. The reversibility of photoalignment was tested for transformations between planar and 90 degrees twist orientation states in a liquid crystal (LC) cell using polarized UV light. No degradation was observed for 100 cycles of transformations. A given twist angle of the LC orientation was obtained in a single step, as well as in a sequence of gradually increasing angles. A hysteresis is revealed in the latter case for planar-twist-planar cycles. The material was used for obtaining patterned orientation of a LC polymer providing similarly good quality photoalignment for UV as well as visible light. High efficiency large area and high spatial frequency optical axis gratings (or, polarization gratings) were demonstrated on a polycarbonate substrate. We show the opportunity of obtaining photoalignment in a multilayer system with single exposure to a polarized light. Finally, we provide evidence of a positive feedback in the dynamics of photoalignment due to the orientational effect of an increasing number of aligned molecules. (C) 2010 Optical Society of America C1 [Steeves, Diane M.; Kimball, Brian R.] USA, Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. [Nersisyan, Sarik R.; Tabiryan, Nelson V.] Beam Engn Adv Measurements Co, Winter Pk, FL 32789 USA. [Chigrinov, Vladimir G.; Kwok, Hoi Sing] Hong Kong Univ Sci & Technol, Dept Elect & Elect Engn, Kowloon, Hong Kong, Peoples R China. RP Kimball, BR (reprint author), USA, Natick Soldier Res, Ctr Dev & Engn, Kansas St, Natick, MA 01760 USA. EM Brian.R.Kimball@us.army.mil FU Hong Kong University of Science and Technology (HKUST) [CERG 612409, CERG 612208, RPC07/08.EG01] FX V. Chigrinov acknowledges support from Hong Kong University of Science and Technology (HKUST) grants CERG 612409, CERG 612208, and RPC07/08.EG01. This document has been approved for public release. U. S. Army Natick Soldier Research, Development and Engineering Center Public Affairs Office U09-192. NR 31 TC 12 Z9 12 U1 5 U2 14 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD APR 1 PY 2010 VL 49 IS 10 BP 1720 EP 1727 DI 10.1364/AO.49.001720 PG 8 WC Optics SC Optics GA 576WD UT WOS:000276179500045 PM 20357851 ER PT J AU Auger, JC Fernandes, GE Aptowicz, KB Pan, YL Chang, RK AF Auger, J. -C. Fernandes, G. E. Aptowicz, K. B. Pan, Y. -L. Chang, R. K. TI Influence of surface roughness on the elastic-light scattering patterns of micron-sized aerosol particles SO APPLIED PHYSICS B-LASERS AND OPTICS LA English DT Article ID BIOLOGICAL PARTICLES; CLASSIFICATION AB The relation between the surface roughness of aerosol particles and the appearance of island-like features in their angle-resolved elastic-light scattering patterns is investigated both experimentally and with numerical simulation. Elastic scattering patterns of polystyrene spheres, Bacillus subtilis spores and cells, and NaCl crystals are measured and statistical properties of the island-like intensity features in their patterns are presented. The island-like features for each class of particle are found to be similar; however, principal-component analysis applied to extracted features is able to differentiate between some of the particle classes. Numerically calculated scattering patterns of Chebyshev particles and aggregates of spheres are analyzed and show qualitative agreement with experimental results. C1 [Auger, J. -C.; Fernandes, G. E.; Chang, R. K.] Yale Univ, Ctr Laser Diagnost, New Haven, CT 06520 USA. [Auger, J. -C.; Fernandes, G. E.; Chang, R. K.] Yale Univ, Dept Appl Phys, New Haven, CT 06520 USA. [Aptowicz, K. B.] W Chester Univ, Dept Phys, W Chester, PA 19383 USA. [Pan, Y. -L.] USA, Res Lab, Adelphi, MD 20783 USA. RP Auger, JC (reprint author), Yale Univ, Ctr Laser Diagnost, New Haven, CT 06520 USA. EM augerjc@gmail.com FU Defense Threat Reduction Agency FX This research was supported by the Defense Threat Reduction Agency under the Physical Science and Technology Basic Research Program. NR 18 TC 7 Z9 7 U1 2 U2 13 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0946-2171 J9 APPL PHYS B-LASERS O JI Appl. Phys. B-Lasers Opt. PD APR PY 2010 VL 99 IS 1-2 BP 229 EP 234 DI 10.1007/s00340-010-3914-0 PG 6 WC Optics; Physics, Applied SC Optics; Physics GA 573EW UT WOS:000275892200035 ER PT J AU Johnson, MS McFarland, CA Bazar, MA Quinn, MJ LaFiandra, EM Talent, LG AF Johnson, Mark S. McFarland, Craig A. Bazar, Matthew A. Quinn, Michael J., Jr. LaFiandra, Emily May Talent, Larry G. TI Toxicity of Octahydro-1,3,5,7-Tetranitro-1,3,5,7-Tetrazocine (HMX) in Three Vertebrate Species SO ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article ID EXPOSURE; 2,4,6-TRINITROTOLUENE; STAGEWISE; FATE AB The explosive, octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine or high-melting explosive (HMX), has been found in soils in areas used for testing and training by the military. Many of these areas contain habitat for valued wildlife species. In an effort to better understand the environmental consequences from exposure, a reptilian (western fence lizard [Sceloporus occidentalis]), an amphibian (red-backed salamander [Plethodon cinereus]), and a mammalian species (rabbit [Oryctolagus cuniculus]) were exposed to HMX under controlled laboratory conditions. Lizards and rabbits were exposed to HMX by way of corn oil through gavage, and salamanders were exposed to HMX in soil. Two deaths occurred from acute oral exposures to lizards to 5000 mg HMX/kg BW. Histological and gross pathologic assessment suggested gut impaction as a possible cause of death. Salamanders exposed to concentrations of HMX in soil a parts per thousand currency sign1970 mg HMX/kg soil for 10 days did not show adverse effects. Rabbits, however, showed neurologic effects manifested as hyperkinetic events with convulsions at > 24 h after oral exposures. An LD(50) for rabbits was calculated as 93 mg/kg (95% confidence interval 76-117). A subacute 14-day testing regime found a lowest observed effect level of 10 mg/kg-d and a no observed adverse effect level of 5 mg/kg-d based on hyperkinesia and seizure incidence, although changes suggesting functional hepatic alterations were also found. These data suggest that physiologic differences between species, particularly in gastrointestinal structure and function, can affect the absorption of HMX and hence lead to marked differences in toxicity from exposure to the same compound. C1 [Johnson, Mark S.; McFarland, Craig A.; Bazar, Matthew A.; Quinn, Michael J., Jr.; LaFiandra, Emily May] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. [Talent, Larry G.] Oklahoma State Univ, Dept Nat Resource Ecol & Management, Stillwater, OK 74078 USA. RP Johnson, MS (reprint author), USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. EM mark.s.johnson@us.army.mil FU Strategic Environmental Research and Development (SERDP) program [ER1420] FX We thank Curtis Oliver and Michael Hable for analytic chemistry support, Patricia Beall for laboratory coordination, Kristie Mozzachio and Kyleigh Mahard for histopathology, and Ann Schiavetta for veterinary care. This work was funded by the Strategic Environmental Research and Development (SERDP) program through ER1420. The views expressed in this article are those of the authors and do not necessarily reflect the views and policies of the United States Army. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 24 TC 4 Z9 4 U1 1 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0090-4341 J9 ARCH ENVIRON CON TOX JI Arch. Environ. Contam. Toxicol. PD APR PY 2010 VL 58 IS 3 BP 836 EP 843 DI 10.1007/s00244-009-9431-7 PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 581GV UT WOS:000276510700037 PM 20012743 ER PT J AU Heller, CE AF Heller, Charles E. TI The US Army, the Civilian Conservation Corps, and Leadership for World War II, 1933-1942 SO ARMED FORCES & SOCIETY LA English DT Article DE Civilian Conservation Corps (CCC); Great Depression; World War II mobilization; interwar period AB Prior to World War II, the U.S. Army numbered 187,000 soldiers. Its growth to more than 8 million was a significant accomplishment. Little known to most, the Franklin D. Roosevelt administration's youth program, the Civilian Conservation Corps (CCC), provided the pretrained manpower to fill the U.S. Army's ranks upon mobilization with men who readily assumed the role of Non-Commissioned Officers (NCOs). It also gave Organized Reserve Corps officers the opportunity to occupy leadership positions, an experience that would have been unavailable otherwise. By the same token, it allowed the Regular Army to assess the leadership potential of both Regular and Reserve Officers in leading future citizen soldiers. Last, it provided the Army with an opportunity to exercise its mobilization plans. C1 USA, Command & Gen Staff Coll, Dept Command & Leadership, Ft Leavenworth, KS USA. RP Heller, CE (reprint author), USA, Command & Gen Staff Coll, Dept Command & Leadership, Ft Leavenworth, KS USA. NR 32 TC 1 Z9 1 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD APR PY 2010 VL 36 IS 3 BP 439 EP 453 DI 10.1177/0095327X09333944 PG 15 WC Political Science; Sociology SC Government & Law; Sociology GA 571GF UT WOS:000275739100003 ER PT J AU Mizuno, DR Kraemer, KE Flagey, N Billot, N Shenoy, S Paladini, R Ryan, E Noriega-Crespo, A Carey, SJ AF Mizuno, D. R. Kraemer, K. E. Flagey, N. Billot, N. Shenoy, S. Paladini, R. Ryan, E. Noriega-Crespo, A. Carey, S. J. TI A CATALOG OF MIPSGAL DISK AND RING SOURCES SO ASTRONOMICAL JOURNAL LA English DT Article DE catalogs; infrared: ISM; planetary nebulae: general ID SPITZER-SPACE-TELESCOPE; INNER GALACTIC PLANE; IMAGING SURVEY; MU-M; NEBULA; DISCOVERY; GLIMPSE; CANDIDATES; OBJECTS; IMAGES AB We present a catalog of 416 extended, resolved, disk and ringlike objects as detected in theMIPSGAL 24 mu m survey of the Galactic plane. This catalog is the result of a search in the MIPSGAL image data for generally circularly symmetric, extended "bubbles" without prior knowledge or expectation of their physical nature. Most of the objects have no extended counterpart at 8 mu m or 70 mu m, with less than 20% detections at each wavelength. For the 54 objects with central point sources, the sources are nearly always seen in all Infrared Array Camera bands. About 70 objects (16%) have been previously identified, with another 35 listed as Infrared Astronomical Satellite sources. Among the identified objects, those with central sources are mostly listed as emission-line stars, but with other source types including supernova remnants (SNRs), luminous blue variables, and planetary nebulae (PNe). The 57 identified objects (of 362) without central sources are nearly all PNe (similar to 90%), which suggests that a large fraction of the 300+ unidentified objects in this category are also PNe. These identifications suggest that this is primarily a catalog of evolved stars. Also included in the catalog are two filamentary objects that are almost certainly SNRs, and 10 unusual compact extended objects discovered in the search. Two of these show remarkable spiral structure at both 8 mu m and 24 mu m. These are likely background galaxies previously hidden by the intervening Galactic plane. C1 [Mizuno, D. R.] Boston Coll, Inst Sci Res, Chestnut Hill, MA 02467 USA. [Kraemer, K. E.] USA, Res Lab, RVBYB, Hanscom Afb, MA 01731 USA. [Flagey, N.; Paladini, R.; Noriega-Crespo, A.; Carey, S. J.] CALTECH, Spitzer Sci Ctr, Pasadena, CA 91125 USA. [Billot, N.] CALTECH, Infrared Proc & Anal Ctr, Pasadena, CA 91125 USA. [Shenoy, S.] NASA, Ames Res Ctr, Moffett Field, CA 94035 USA. [Ryan, E.] Univ Minnesota, Dept Astron, Minneapolis, MN 55455 USA. RP Mizuno, DR (reprint author), Boston Coll, Inst Sci Res, 140 Commonwealth Ave, Chestnut Hill, MA 02467 USA. EM afrl.rvb.pa@hanscom.af.mil OI Kraemer, Kathleen/0000-0002-2626-7155 NR 32 TC 35 Z9 35 U1 0 U2 1 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND SN 0004-6256 J9 ASTRON J JI Astron. J. PD APR PY 2010 VL 139 IS 4 BP 1542 EP 1552 DI 10.1088/0004-6256/139/4/1542 PG 11 WC Astronomy & Astrophysics SC Astronomy & Astrophysics GA 568BO UT WOS:000275496900023 ER PT J AU Iversen, P McLeod, DG See, WA Morris, T Armstrong, J Wirth, MP AF Iversen, Peter McLeod, David G. See, William A. Morris, Thomas Armstrong, Jon Wirth, Manfred P. CA Casodex Early Prostate Canc Triali TI Antiandrogen monotherapy in patients with localized or locally advanced prostate cancer: final results from the bicalutamide Early Prostate Cancer programme at a median follow-up of 9.7 years SO BJU INTERNATIONAL LA English DT Article DE adjuvant; antiandrogen; bicalutamide; localized; locally advanced; prostate cancer ID ANDROGEN DEPRIVATION THERAPY; QUALITY-OF-LIFE; RADICAL PROSTATECTOMY; STANDARD CARE; PELVIC LYMPHADENECTOMY; HORMONAL-THERAPY; RANDOMIZED-TRIAL; 150 MG; ADJUVANT; MEN AB OBJECTIVE To evaluate the efficacy and tolerability of bicalutamide 150 mg once-daily as immediate hormonal therapy in patients with prostate cancer or as adjuvant to radical prostatectomy or radiotherapy. PATIENTS AND METHODS In all, 8113 patients with localized (T1-2, N0/Nx) or locally advanced (T3-4, any N; or any T, N+) prostate cancer (all M0) were enrolled in three complementary, double-blind, placebo-controlled trials. Patients were randomized to receive standard care plus either oral bicalutamide 150 mg once-daily or oral placebo. Primary endpoints were progression-free survival (PFS) and overall survival (OS). Data were collated from individual trials and evaluated in a combined analysis. RESULTS Overall, at a median follow-up of 9.7 years, bicalutamide significantly improved PFS (hazard ratio 0.85, 95% confidence interval 0.79-0.91; P = 0.001). Compared with placebo there was no difference in OS (hazard ratio 1.01, P = 0.77). Patients who derived benefit from bicalutamide in terms of PFS were those with locally advanced disease, with OS significantly favouring bicalutamide in patients with locally advanced disease undergoing radiotherapy (P = 0.031). Patients with localized disease showed no clinically or statistically significant improvements in PFS; there was a survival trend in favour of placebo in patients with localized disease undergoing watchful waiting (P = 0.054). The overall tolerability of bicalutamide was consistent with previous analyses, with breast pain (73.7%) and gynaecomastia (68.8%) the most frequently reported adverse events in patients randomized to bicalutamide. CONCLUSIONS Bicalutamide 150 mg, either as monotherapy or adjuvant to standard care, improved PFS in patients with locally advanced prostate cancer, but not in patients with localized disease. A pre-planned subset analysis showed a benefit for OS in patients with locally advanced disease undergoing radiotherapy. Bicalutamide 150 mg might represent an alternative for patients with locally advanced prostate cancer considering androgen-deprivation therapy. C1 [Iversen, Peter] Univ Copenhagen, Dept Urol, Rigshosp, DK-2100 Copenhagen, Denmark. [McLeod, David G.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [See, William A.] Med Coll Wisconsin, Milwaukee, WI 53226 USA. [Morris, Thomas; Armstrong, Jon] AstraZeneca, Macclesfield, Cheshire, England. [Wirth, Manfred P.] Tech Univ Dresden, Dresden, Germany. RP Iversen, P (reprint author), Univ Copenhagen, Dept Urol, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. EM peter.iversen@rh.regionh.dk FU AstraZeneca FX The EPC programme was funded by AstraZeneca. We thank Sarah Lewis, from Complete Medical Communications, who provided medical writing support funded by AstraZeneca. Casodex (R) and Zoladex (R) are registered trademarks of the AstraZeneca group of companies. Clinical trial registration numbers: Study 0023 (NCT00657904), Study 0024 (NCT00673205), Study 0025 (NCT00672282). NR 25 TC 37 Z9 42 U1 0 U2 6 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1464-4096 J9 BJU INT JI BJU Int. PD APR PY 2010 VL 105 IS 8 BP 1074 EP 1081 DI 10.1111/j.1464-410X.2010.09319.x PG 8 WC Urology & Nephrology SC Urology & Nephrology GA 574SO UT WOS:000276013800006 PM 22129214 ER PT J AU Pratt, WD Wang, D Nichols, DK Luo, M Woraratanadharm, J Dye, JM Holman, DH Dong, JY AF Pratt, William D. Wang, Danher Nichols, Donald K. Luo, Min Woraratanadharm, Jan Dye, John M. Holman, David H. Dong, John Y. TI Protection of Nonhuman Primates against Two Species of Ebola Virus Infection with a Single Complex Adenovirus Vector SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID VACCINE PROTECTS; MARBURG VIRUS; HEMORRHAGIC-FEVER; RHESUS-MONKEYS; GUINEA-PIGS; NEUTRALIZING ANTIBODIES; BIOLOGICAL WEAPONS; IMMUNE-RESPONSES; CHALLENGE; SUDAN AB Ebola viruses are highly pathogenic viruses that cause outbreaks of hemorrhagic fever in humans and other primates. To meet the need for a vaccine against the several types of Ebola viruses that cause human diseases, we developed a multivalent vaccine candidate (EBO7) that expresses the glycoproteins of Zaire ebolavirus (ZEBOV) and Sudan ebolavirus (SEBOV) in a single complex adenovirus-based vector (CAdVax). We evaluated our vaccine in nonhuman primates against the parenteral and aerosol routes of lethal challenge. EBO7 vaccine provided protection against both Ebola viruses by either route of infection. Significantly, protection against SEBOV given as an aerosol challenge, which has not previously been shown, could be achieved with a boosting vaccination. These results demonstrate the feasibility of creating a robust, multivalent Ebola virus vaccine that would be effective in the event of a natural virus outbreak or biological threat. C1 [Pratt, William D.; Nichols, Donald K.; Dye, John M.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Wang, Danher; Luo, Min; Woraratanadharm, Jan; Holman, David H.; Dong, John Y.] GenPhar Inc, Div Biodefense Vaccines, Mt Pleasant, SC 29464 USA. [Dong, John Y.] Med Univ S Carolina, Dept Microbiol & Immunol, Charleston, SC 29425 USA. RP Pratt, WD (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM williamd.pratt@us.army.mil FU Defense Threat Reduction Agency [1.1C0001_07_RD_B, DAMD17-02-2-0035]; U. S. Public Health Service, National Institute of Allergy and Infectious Diseases [AI070382] FX We thank Carlton Rice for animal care and the staff of the Center for Aerobiological Sciences, USAMRIID, particularly Mathew Lackemeyer, for assistance with aerosol exposures. We also thank Ana Kuehne, Jay Wells, and Ramon Ortiz for their technical assistance.; Work on filoviruses at USAMRIID was funded by the Defense Threat Reduction Agency (project number 1.1C0001_07_RD_B and Cooperative Agreement DAMD17-02-2-0035) and in part by U. S. Public Health Service grant AI070382 from the National Institute of Allergy and Infectious Diseases to J.Y.D. NR 45 TC 53 Z9 57 U1 2 U2 10 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD APR PY 2010 VL 17 IS 4 BP 572 EP 581 DI 10.1128/CVI.00467-09 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 576TG UT WOS:000276170900013 PM 20181765 ER PT J AU Goo, R Miller, M McArthur, T AF Goo, Roy Miller, Michael McArthur, Todd TI Provider Compliance With the Food and Drug Administration Recommendation to Avoid the Use of Over-the-Counter (Nonprescription) Cough and Cold Medications in Children Younger Than 2 Years SO CLINICAL PEDIATRICS LA English DT Article C1 [Goo, Roy; Miller, Michael] Tripler Army Med Ctr, Honolulu, HI 96851 USA. [McArthur, Todd] Madigan Army Med Ctr, Dept Emergency Med, Ft Lewis, WA USA. RP Miller, M (reprint author), Tripler Army Med Ctr, 1 Jarett White Rd, Honolulu, HI 96851 USA. EM michael.adam.miller@us.army.mil NR 9 TC 1 Z9 1 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0009-9228 J9 CLIN PEDIATR JI Clin. Pediatr. PD APR PY 2010 VL 49 IS 4 BP 384 EP 387 DI 10.1177/0009922809343719 PG 4 WC Pediatrics SC Pediatrics GA 577XD UT WOS:000276256400013 PM 19745097 ER PT J AU Valisetty, R Rajendran, A Grove, D AF Valisetty, R. Rajendran, A. Grove, D. TI Mesh Effects in Predictions of Progressive Damage in 3D Woven Composites SO CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES LA English DT Article DE Fabrics/textiles; Stress concentrations; Impact behavior; Damage Mechanics ID TRANSFORMATION FIELD ANALYSIS; IMPACT; MODEL; HOMOGENIZATION; FAILURE AB A multi-scale model exhibiting progressive damage is considered for a 3D-woven composite. It is based on the evolution of some fundamental damage modes in a representative volume element (RVE) of a composite's woven architecture. The overall response of a woven composite due to a variety of damage modes is computationally obtained through a transformation field analysis (TFA) that is capable of quantifying the effects of spatial distribution of micro stresses and strains on strength. Since the model is computationally intensive, its numerical requirements are to be understood before it can successfully be used in design studies or in conjunction with Lagrangian explicit codes. This paper examines the effect of the local micro-mesh size on the progression of certain damage modes in 3D-woven composites and the predicted overall response. C1 [Valisetty, R.; Grove, D.] USA, Comput & Inform Sci Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Rajendran, A.] Univ Mississippi, Dept Mech Engn, University, MS 38677 USA. RP Valisetty, R (reprint author), USA, Comput & Inform Sci Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM raj@olemiss.edu FU U.S. Army Research Office, Durham, NC FX The authors are grateful to Dr. Yehia Bahei-El-Din, who is currently with the British University, Cairo, Egypt, for his suggestions to the manuscript. This work was partially funded by the U.S. Army Research Office, Durham, NC. The simulations were performed in Army's MSRC at Aberdeen Proving Ground, MD. NR 25 TC 0 Z9 0 U1 0 U2 1 PU TECH SCIENCE PRESS PI NORCROSS PA 6825 JIMMY CARTER BLVD, STE 1850, NORCROSS, GA 30071 USA SN 1526-1492 J9 CMES-COMP MODEL ENG JI CMES-Comp. Model. Eng. Sci. PD APR PY 2010 VL 60 IS 1 BP 41 EP 71 PG 31 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Mathematics GA 643PU UT WOS:000281311600002 ER PT J AU Ditman, T Brunye, TT Mahoney, CR Taylor, HA AF Ditman, Tali Brunye, Tad T. Mahoney, Caroline R. Taylor, Holly A. TI Simulating an enactment effect: Pronouns guide action simulation during narrative comprehension SO COGNITION LA English DT Article DE Perspective-taking; Embodied cognition; Discourse comprehension; Language; Action understanding ID LANGUAGE COMPREHENSION; SITUATION MODELS; PERSPECTIVE-TAKING; MOTOR RESONANCE; MEMORY; INFORMATION; REPRESENTATIONS; ACCESSIBILITY; CONSTRUCTION; OBJECTS AB Recent research has suggested that reading involves the mental simulation of events and actions described in a text. It is possible however that previous findings did not tap into processes engaged during natural reading but rather those triggered by task demands. The present study examined whether readers spontaneously mentally simulate the actions described in simple narratives by using a memory task that did not encourage the formation of mental images. During encoding, participants read event scenarios preceded by 'I', 'You', or 'He', and then 10 min (Experiment 1) or 3 days later (Experiment 2), we examined memory for action and descriptive elements of these scenarios. Given previous research demonstrating that readers simulate described actions preceded by 'You' from an actor's perspective, we predicted that such action statements would be better remembered than those preceded by 'He' or 'I' a simulated enactment effect. Results of both experiments supported this prediction; readers had better memory for actions but not descriptive information (10 min and 3 days later) after reading statements preceded by 'You'. Results demonstrate that readers spontaneously mentally simulate actions during language comprehension and take different mental perspectives, even when doing so is not necessary to perform the task. (C) 2009 Elsevier B.V. All rights reserved. C1 [Ditman, Tali; Brunye, Tad T.; Mahoney, Caroline R.; Taylor, Holly A.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. [Ditman, Tali] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA. [Brunye, Tad T.; Mahoney, Caroline R.] USA, NSRDEC, Natick, MA 01760 USA. RP Ditman, T (reprint author), Tufts Univ, Dept Psychol, 490 Boston Ave, Medford, MA 02155 USA. EM tali.ditman@tufts.edu RI 江, 鈺麒/G-1379-2014 NR 53 TC 28 Z9 29 U1 1 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0010-0277 J9 COGNITION JI Cognition PD APR PY 2010 VL 115 IS 1 BP 172 EP 178 DI 10.1016/j.cognition.2009.10.014 PG 7 WC Psychology, Experimental SC Psychology GA 576EF UT WOS:000276126400017 PM 19939357 ER PT J AU Adley, MD Frank, AO Danielson, KT Akers, SA O'Daniel, JL AF Adley, Mark D. Frank, Andreas O. Danielson, Kent T. Akers, Stephen A. O'Daniel, James L. TI The virtual penetration laboratory: new developments for projectile penetration in concrete SO COMPUTERS AND CONCRETE LA English DT Article DE penetration mechanics; constitutive modeling; evolutionary algorithms ID MICROPLANE MODEL; STRESS AB This paper discusses new capabilities developed for the Virtual Penetration Laboratory (VPL) software package to address the challenges of determining Penetration Resistance (PR) equations for concrete materials. Specifically, the paper introduces a three-invariant concrete constitutive model recently developed by the authors. The Advanced Fundamental Concrete (AFC) model was developed to provide a fast-running predictive model to simulate the behavior of concrete and other high-strength geologic materials. The Continuous Evolutionary Algorithms (CEA) automatic fitting algorithms used to fit the new model are discussed, and then examples are presented to demonstrate the effectiveness of the new AFC model. Finally, the AFC model in conjunction with the VPL software package is used to develop a PR equation for a concrete material. C1 [Adley, Mark D.; Frank, Andreas O.; Danielson, Kent T.; Akers, Stephen A.; O'Daniel, James L.] USA, Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. RP Adley, MD (reprint author), USA, Engineer Res & Dev Ctr, Geotech & Struct Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM mark.d.adley@usace.army.mil NR 16 TC 3 Z9 3 U1 0 U2 3 PU TECHNO-PRESS PI DAEJEON PA PO BOX 33, YUSEONG, DAEJEON 305-600, SOUTH KOREA SN 1598-8198 J9 COMPUT CONCRETE JI Comput. Concr. PD APR PY 2010 VL 7 IS 2 SI SI BP 87 EP 102 PG 16 WC Computer Science, Interdisciplinary Applications; Construction & Building Technology; Engineering, Civil; Materials Science, Characterization & Testing SC Computer Science; Construction & Building Technology; Engineering; Materials Science GA 723ZH UT WOS:000287545400002 ER PT J AU O'Daniel, J Adley, M Danielson, K DiPaolo, B Boone, N AF O'Daniel, James Adley, Mark Danielson, Kent DiPaolo, Beverly Boone, Nicholas TI Comparing finite element and meshfree particle formulations for projectile penetration into fiber reinforced concrete SO COMPUTERS AND CONCRETE LA English DT Article DE Fiber Reinforced Concrete; finite element; meshfree; penetration ID HYDRODYNAMICS; ALGORITHM AB Penetration of a fragment-like projectile into Fiber Reinforced Concrete (FRC) was simulated using finite element (FE) and particle formulations. Extreme deformations and failure of the material during the penetration event were modeled with multiple approaches to evaluate how well each represented the actual physics of the penetration process and compared to experimental data. A Fragment Simulating Projectile (FSP) normally impacting a flat, square plate of FRC was modeled using two target thicknesses to examine the different levels of damage. The thinner plate was perforated by the FSP, while the thicker plate captured the FSP and only allowed penetration part way through the thickness. Full three dimensional simulations were performed, so the capability was present for non-symmetric FRC behavior and possible projectile rotation in all directions. These calculations assessed the ability of the finite element and particle formulations to calculate penetration response while assessing criteria necessary to perform the computations. The numerical code EPIC contains the element and particle formulations, as well as the explicit methodology and constitutive models, needed to perform these simulations. C1 [O'Daniel, James; Adley, Mark] USAF, Res Lab, Eglin AFB, USA Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP O'Daniel, J (reprint author), USAF, Res Lab, Eglin AFB, USA Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM James.L.O'Daniel@usace.army.mil NR 18 TC 1 Z9 1 U1 1 U2 4 PU TECHNO-PRESS PI DAEJEON PA PO BOX 33, YUSEONG, DAEJEON 305-600, SOUTH KOREA SN 1598-8198 J9 COMPUT CONCRETE JI Comput. Concr. PD APR PY 2010 VL 7 IS 2 SI SI BP 103 EP 118 PG 16 WC Computer Science, Interdisciplinary Applications; Construction & Building Technology; Engineering, Civil; Materials Science, Characterization & Testing SC Computer Science; Construction & Building Technology; Engineering; Materials Science GA 723ZH UT WOS:000287545400003 ER PT J AU Littlefield, D Walls, KC Danielson, KT AF Littlefield, David Walls, Kenneth C. Danielson, Kent T. TI Integration of the microplane constitutive model into the EPIC code SO COMPUTERS AND CONCRETE LA English DT Article DE microplane model; constitutive model framework; EPIC code ID CONCRETE; STRESS; STRAIN AB In this work the implementation of a production-level port of the Microplane constitutive model for concrete into the EPIC code is described. The port follows guidelines outlined in the Material Model Module (MMM) standard used in EPIC to insure a seamless interface with the existing code. Certain features of the model were not implemented using the MMM interface due to compatibility reasons; for example, a separate module was developed to initialize, store and update internal state variables. Objective strain and deformation measures for use in the material model were also implemented into the code. Example calculations were performed and illustrate the veracity of this new implementation. C1 [Littlefield, David] Univ Alabama, Dept Mech Engn, Birmingham, AL 35294 USA. [Danielson, Kent T.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Littlefield, D (reprint author), Univ Alabama, Dept Mech Engn, Birmingham, AL 35294 USA. EM littlefield@uab.edu FU DoD FX This work was supported by the DoD High Performance Computing Modernization Program (HPCMP) under the Productivity Enhancement and Technology Transfer (PET) Program. NR 16 TC 2 Z9 2 U1 2 U2 3 PU TECHNO-PRESS PI DAEJEON PA PO BOX 33, YUSEONG, DAEJEON 305-600, SOUTH KOREA SN 1598-8198 J9 COMPUT CONCRETE JI Comput. Concr. PD APR PY 2010 VL 7 IS 2 SI SI BP 145 EP 158 PG 14 WC Computer Science, Interdisciplinary Applications; Construction & Building Technology; Engineering, Civil; Materials Science, Characterization & Testing SC Computer Science; Construction & Building Technology; Engineering; Materials Science GA 723ZH UT WOS:000287545400005 ER PT J AU Danielson, KT Adley, MD O'Daniel, JL AF Danielson, Kent T. Adley, Mark D. O'Daniel, James L. TI Numerical procedures for extreme impulsive loading on high strength concrete structures SO COMPUTERS AND CONCRETE LA English DT Article DE nonlinear finite element analysis; reinforced concrete; microplane constitutive model; parallel computing ID MICROPLANE MODEL; STRESS; STRAIN AB This paper demonstrates numerical techniques for complex large-scale modeling with microplane constitutive theories for reinforced high strength concrete, which for these applications, is defined to be around the 7000 psi (48 MPa) strength as frequently found in protective structural design. Applications involve highly impulsive loads, such as an explosive detonation or impact-penetration event. These capabilities were implemented into the authors' finite element code, Para Able and the PRONTO 3D code from Sandia National Laboratories. All materials are explicitly modeled with eight-noded hexahedral elements. The concrete is modeled with a microplane constitutive theory, the reinforcing steel is modeled with the Johnson-Cook model, and the high explosive material is modeled with a JWL equation of state and a programmed burn model. Damage evolution, which can be used for erosion of elements and/or for post-analysis examination of damage, is extracted from the microplane predictions and computed by a modified Holmquist-Johnson-Cook approach that relates damage to levels of inelastic strain increment and pressure. Computation is performed with MPI on parallel processors. Several practical analyses demonstrate that large-scale analyses of this type can be reasonably run on large parallel computing systems. C1 [Danielson, Kent T.; Adley, Mark D.; O'Daniel, James L.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Danielson, KT (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Kent.T.Danielson@us.army.mil FU DOD at the ERDC DOD Supercomputing Resource Center (DSRC) FX Permission to publish was granted by Director, Geotechnical and Structures Laboratory. The work was supported in part by grants of computer time from the DOD High Performance Computing Modernization Program at the ERDC DOD Supercomputing Resource Center (DSRC). NR 18 TC 5 Z9 5 U1 2 U2 5 PU TECHNO-PRESS PI DAEJEON PA PO BOX 33, YUSEONG, DAEJEON 305-600, SOUTH KOREA SN 1598-8198 J9 COMPUT CONCRETE JI Comput. Concr. PD APR PY 2010 VL 7 IS 2 SI SI BP 159 EP 167 PG 9 WC Computer Science, Interdisciplinary Applications; Construction & Building Technology; Engineering, Civil; Materials Science, Characterization & Testing SC Computer Science; Construction & Building Technology; Engineering; Materials Science GA 723ZH UT WOS:000287545400006 ER PT J AU Roth, MJ Slawson, TR Flores, OG AF Roth, M. Jason Slawson, Thomas R. Flores, Omar G. TI Flexural and tensile properties of a glass fiber-reinforced ultra-high-strength concrete: an experimental, micromechanical and numerical study SO COMPUTERS AND CONCRETE LA English DT Article DE ultra-high-strength concrete; alkali resistant glass fiber; micromechanical model; tensile failure function; finite element analysis; concrete damage plasticity ID CEMENT-BASED COMPOSITES; BEHAVIOR; FRACTURE; TOUGHNESS; INTERFACE; MODEL AB The focus of this research effort was characterization of the flexural and tensile properties of a specific ultra-high-strength, fiber-reinforced concrete material. The material exhibited a mean unconfined compressive strength of approximately 140 MPa and was reinforced with short, randomly distributed alkali resistant glass fibers. As a part of the study, coupled experimental, analytical and numerical investigations were performed. Flexural and direct tension tests were first conducted to experimentally characterize material behavior. Following experimentation, a micromechanically-based analytical model was utilized to calculate the material's tensile failure response, which was compared to the experimental results. Lastly, to investigate the relationship between the tensile failure and flexural response, a numerical analysis of the flexural experiments was performed utilizing the experimentally developed tensile failure function. Results of the experimental, analytical and numerical investigations are presented herein. C1 [Roth, M. Jason; Slawson, Thomas R.; Flores, Omar G.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Roth, MJ (reprint author), USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM michael.j.roth@usace.army.mil NR 36 TC 4 Z9 4 U1 0 U2 3 PU TECHNO-PRESS PI DAEJEON PA PO BOX 33, YUSEONG, DAEJEON 305-600, SOUTH KOREA SN 1598-8198 J9 COMPUT CONCRETE JI Comput. Concr. PD APR PY 2010 VL 7 IS 2 SI SI BP 169 EP 190 PG 22 WC Computer Science, Interdisciplinary Applications; Construction & Building Technology; Engineering, Civil; Materials Science, Characterization & Testing SC Computer Science; Construction & Building Technology; Engineering; Materials Science GA 723ZH UT WOS:000287545400007 ER PT J AU Williams, EM Graham, SS Akers, SA Reed, PA Rushing, TS AF Williams, E. M. Graham, S. S. Akers, S. A. Reed, P. A. Rushing, T. S. TI Constitutive property behavior of an ultra-high-performance concrete with and without steel fibers SO COMPUTERS AND CONCRETE LA English DT Article DE ultra-high-performance concrete; steel fibers; mechanical response AB A laboratory investigation was conducted to characterize the constitutive property behavior of Cor-Tuf, an ultra-high-performance composite concrete. Mechanical property tests (hydrostatic compression, unconfined compression (UC), triaxial compression (TXC), unconfined direct pull (DP), uniaxial strain, and uniaxial-strain-load/constant-volumetric-strain tests) were performed on specimens prepared from concrete mixtures with and without steel fibers. From the UC and TXC test results, compression failure surfaces were developed for both sets of specimens. Both failure surfaces exhibited a continuous increase in maximum principal stress difference with increasing confining stress. The DP tests results determined the unconfined tensile strengths of the two mixtures. The tensile strength of each mixture was less than the generally assumed tensile strength for conventional strength concrete, which is 10 percent of the unconfined compressive strength. Both concretes behaved similarly, but Cor-Tuf with steel fibers exhibited slightly greater strength with increased confining pressure, and Cor-Tuf without steel fibers displayed slightly greater compressibility. C1 [Williams, E. M.; Graham, S. S.; Akers, S. A.; Reed, P. A.; Rushing, T. S.] USA, Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS USA. RP Williams, EM (reprint author), USA, Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS USA. EM erin.m.williams@usace.army.mil NR 5 TC 11 Z9 11 U1 0 U2 3 PU TECHNO-PRESS PI DAEJEON PA PO BOX 33, YUSEONG, DAEJEON 305-600, SOUTH KOREA SN 1598-8198 J9 COMPUT CONCRETE JI Comput. Concr. PD APR PY 2010 VL 7 IS 2 SI SI BP 191 EP 202 PG 12 WC Computer Science, Interdisciplinary Applications; Construction & Building Technology; Engineering, Civil; Materials Science, Characterization & Testing SC Computer Science; Construction & Building Technology; Engineering; Materials Science GA 723ZH UT WOS:000287545400008 ER PT J AU Chung, K Renz, EM Cancio, LC Wolf, S AF Chung, Kevin Renz, Evan M. Cancio, Leopoldo C. Wolf, Steven TI Regarding critical care of the burn patient: The first 48 hours SO CRITICAL CARE MEDICINE LA English DT Letter ID RESUSCITATION; FLUID C1 [Chung, Kevin; Renz, Evan M.; Cancio, Leopoldo C.] USA, Inst Surg Res, Burn Ctr, Ft Sam Houston, TX 78234 USA. [Wolf, Steven] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA. RP Chung, K (reprint author), USA, Inst Surg Res, Burn Ctr, Ft Sam Houston, TX 78234 USA. OI Wolf, Steven/0000-0003-2972-3440 NR 5 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD APR PY 2010 VL 38 IS 4 BP 1225 EP 1225 DI 10.1097/CCM.0b013e3181cd0f87 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 581CW UT WOS:000276499700035 PM 20335710 ER PT J AU Henning, JS Firoz, BF AF Henning, J. Scott Firoz, Bahar F. TI The Use of a Cooling Device as an Analgesic Before Injectable Local Anesthesia in the Pediatric Population SO DERMATOLOGIC SURGERY LA English DT Article ID EMERGENCY-DEPARTMENT; ETHYL CHLORIDE; INTRAVENOUS CANNULATION; VAPOCOOLANT SPRAY; PAIN; CHILDREN; VENIPUNCTURE; INSERTION; PLACEBO C1 [Henning, J. Scott] Brooke Army Med Ctr, Houston, TX USA. [Firoz, Bahar F.] Univ Texas Hlth Sci Ctr San Antonio, Dept Dermatol & Mohs Surg, San Antonio, TX 78229 USA. RP Henning, JS (reprint author), Dept Dermatol, 3851 Roger Brooke Dr, Houston, TX 78251 USA. EM Jeffrey.henning@lackland.af.mil NR 17 TC 2 Z9 2 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1076-0512 J9 DERMATOL SURG JI Dermatol. Surg. PD APR PY 2010 VL 36 IS 4 BP 520 EP 523 DI 10.1111/j.1524-4725.2010.01487.x PG 4 WC Dermatology; Surgery SC Dermatology; Surgery GA 576SL UT WOS:000276168500013 PM 20187896 ER PT J AU Bennett, JW Mende, K Herrera, ML Yu, X Lewis, JS Wickes, BL Jorgensen, JH Murray, CK AF Bennett, Jason W. Mende, Katrin Herrera, Monica L. Yu, Xin Lewis, James S., II Wickes, Brian L. Jorgensen, James H. Murray, Clinton K. TI Mechanisms of carbapenem resistance among a collection of Enterobacteriaceae clinical isolates in a Texas city SO DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE LA English DT Article DE Carbapenem; Enterobacteriaceae; Extended spectrum beta-lactamases; KPC-2; AmpC beta-lactamase; Porins; Texas city ID SPECTRUM BETA-LACTAMASES; KLEBSIELLA-PNEUMONIAE CARBAPENEMASE; GRAM-NEGATIVE BACTERIA; ESCHERICHIA-COLI; PORIN; EXPRESSION; EMERGENCE; ENTEROBACTETIACEAE; CEPHALOSPORINS; ERTAPENEM AB Fourteen Enterobacteriaceae isolates with ertapenem MIC >2 mg/mL were analyzed to identify mechanisms of resistance. All isolates produced extended-spectrum beta-lactamase or AmpC beta-lactamase with variable, but decreased, expression of outer membrane proteins. One Enterobacter cloacae produced derepressed AmpC beta-lactamase, 1 Escherichia colt expressed plasmid-mediated AmpC beta-lactamase, and 1 E. cloacae produced a carbapenemase. Published by Elsevier Inc. C1 [Bennett, Jason W.; Mende, Katrin; Murray, Clinton K.] San Antonio Mil Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. [Mende, Katrin] Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Herrera, Monica L.; Wickes, Brian L.] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, San Antonio, TX 78229 USA. [Yu, Xin] San Antonio Mil Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. [Lewis, James S., II] Univ Hlth Syst, Dept Pharm, San Antonio, TX 78229 USA. [Jorgensen, James H.] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX 78229 USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. EM clinton.murray@amedd.army.mil RI Valle, Ruben/A-7512-2013 NR 25 TC 8 Z9 9 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0732-8893 J9 DIAGN MICR INFEC DIS JI Diagn. Microbiol. Infect. Dis. PD APR PY 2010 VL 66 IS 4 BP 445 EP 448 DI 10.1016/j.diagmicrobio.2009.11.013 PG 4 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA 574FD UT WOS:000275973200016 PM 20226336 ER PT J AU Wilk, JE Bliese, PD Kim, PY Thomas, JL McGurk, D Hoge, CW AF Wilk, Joshua E. Bliese, Paul D. Kim, Paul Y. Thomas, Jeffrey L. McGurk, Dennis Hoge, Charles W. TI Relationship of combat experiences to alcohol misuse among US soldiers returning from the Iraq war SO DRUG AND ALCOHOL DEPENDENCE LA English DT Article DE Alcohol misuse; Combat; Military ID UK ARMED-FORCES; POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; GENERAL-POPULATION; TRAUMATIC EVENTS; SELF-REPORTS; CONSEQUENCES; CONSISTENCY; VETERANS; CARE AB Objective: Studies have shown a relationship between combat experiences and alcohol misuse in military personnel; it is not known if there are specific combat experiences that confer a greater risk. The current study examined the association of specific types of combat experiences with a positive screen for alcohol misuse. Methods: 1120 U.S. soldiers who were members of brigade combat infantry teams were surveyed anonymously 3-4 months after returning from deployment to Iraq regarding their experiences in combat and their physical and mental health. Combat items were independently rated and placed into the following categories: (1) Fighting; (2) Killing; (3) Threat to oneself; (4) Death/injury of others; (5) Atrocities; and, (6) Positive experiences. Alcohol misuse was measured using a 2-item alcohol screen combined with alcohol-related behavioral items. Results: Of the soldiers sampled, 25% (N=275) screened positive for alcohol misuse 3-4 months post-deployment; 12% (N = 125) screened positive and exhibited alcohol-related behavioral problems. Most combat exposure factors were significantly related to alcohol misuse individually. When factors were analyzed simultaneously, soldiers who had higher rates of exposure to the threat of death/injury were significantly more likely to screen positive for alcohol misuse; exposure to atrocities predicted misuse of alcohol with alcohol-related behavioral problems. Conclusions: High exposure to threatening situations and atrocities was associated with a positive screen for alcohol misuse. Clinicians treating combat veterans should be aware of the potential association of alcohol misuse with specific types of experiences and closely follow those soldiers upon their return home. Published by Elsevier Ireland Ltd. C1 [Wilk, Joshua E.; Bliese, Paul D.; Kim, Paul Y.; Thomas, Jeffrey L.; Hoge, Charles W.] USA, Med Res & Mat Command, Div Psychiat & Neurosci, Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. USA, Med Res Unit Europe, Walter Reed Army Inst Res, Med Res & Mat Command, APO, AE 09042 USA. RP Wilk, JE (reprint author), USA, Med Res & Mat Command, Div Psychiat & Neurosci, Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM joshua.wilk@amedd.army.mil NR 29 TC 102 Z9 103 U1 1 U2 11 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0376-8716 J9 DRUG ALCOHOL DEPEN JI Drug Alcohol Depend. PD APR 1 PY 2010 VL 108 IS 1-2 BP 115 EP 121 DI 10.1016/j.drugalcdep.2009.12.003 PG 7 WC Substance Abuse; Psychiatry SC Substance Abuse; Psychiatry GA 579NB UT WOS:000276376600016 PM 20060237 ER PT J AU Dean, TR Hromadka, TV AF Dean, T. R. Hromadka, T. V., II TI A collocation CVBEM using program Mathematica SO ENGINEERING ANALYSIS WITH BOUNDARY ELEMENTS LA English DT Article DE CVBEM; Complex variable boundary elements; Collocation; Complex variables AB The well-known complex variable boundary element method (CVBEM) is extended for using collocation points not located at the usual boundary nodal point locations. In this work, several advancements to the implementation of the CVBEM are presented. The first advancement is enabling the CVBEM nodes to vary in location, impacting the modeling accuracy depending on chosen node locations. A second advancement is determining values of the CVBEM basis function complex coefficients by collocation at evaluation points defined on the problem boundary but separate and distinct from nodal point locations (if some or all nodes are located on the problem boundary). A third advancement is the implementation of these CVBEM modeling features on computer program Mathematica, in order to reduce programming requirements and to take advantage of Mathematica's library of mathematical capabilities and graphics features. Published by Elsevier Ltd. C1 [Hromadka, T. V., II] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Dean, T. R.] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. RP Hromadka, TV (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. NR 4 TC 5 Z9 5 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0955-7997 J9 ENG ANAL BOUND ELEM JI Eng. Anal. Bound. Elem. PD APR PY 2010 VL 34 IS 4 BP 417 EP 422 DI 10.1016/j.enganabound.2009.10.007 PG 6 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Mathematics GA 561UA UT WOS:000275003500012 ER PT J AU Cerco, CF Tillman, D Hagy, JD AF Cerco, Carl F. Tillman, Dorothy Hagy, James D. TI Coupling and comparing a spatially- and temporally-detailed eutrophication model with an ecosystem network model: An initial application to Chesapeake Bay SO ENVIRONMENTAL MODELLING & SOFTWARE LA English DT Article DE CE-QUAL-ICM; Ecopath; Eutrophication; Chesapeake Bay; Atlantic menhaden; Phytoplankton AB Coastal waters are modeled for a variety of purposes including eutrophication remediation and fisheries management. Combining these two approaches provides insights which are not available from either approach independently. Coupling is confounded, however, by differences in model formulations and "currencies." We present here an initial coupling of a spatially- and temporally-detailed eutrophication model, CE-QUAL-ICM, with a network fisheries model, Ecopath. We list commonalities between the models and present algorithms and software for the exchange of information. The models are applied to the central portion of Chesapeake Bay for a contemporary summer period. After comparison of the representations of Chesapeake Bay by the two models, an illustrative example one-way, off-line, coupling is presented. In an initial examination of a 20% increase in predation on phytoplankton by a small, highly-exploited fish (Atlantic menhaden, Brevoortia tyrannus), computed reduction in phytoplankton biomass is accompanied by increased production due to enhanced nutrient recycling. Minimal impact on the structure of the food web or on biomass of higher-trophic level organisms is computed. The algorithms and software can be adapted to alternate eutrophication models and Ecopath applications and provide the first, necessary, steps for subsequent coupling with the time-variable Ecosim model. Published by Elsevier Ltd. C1 [Cerco, Carl F.; Tillman, Dorothy] USA, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. [Hagy, James D.] US EPA, Gulf Breeze, FL 32561 USA. RP Cerco, CF (reprint author), USA, Ctr Res Dev & Engn, Mail Stop EP W,3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM carl.f.cerco@usace.army.mil FU US Army Engineers System-Wide Water Resources Program (SWRRP) FX Funding for this investigation was provided by the US Army Engineers System-Wide Water Resources Program (SWRRP) under the Ecological Modeling Focus Area. For more information on SWRRP, please consult https://swwrp.usace.army.mil/Improvements to an earlier version of this manuscript were guided by helpful comments from the editor and two reviewers. Reviewer 1 suggested the hierarchy of couplings described here. NR 31 TC 22 Z9 22 U1 2 U2 36 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1364-8152 EI 1873-6726 J9 ENVIRON MODELL SOFTW JI Environ. Modell. Softw. PD APR PY 2010 VL 25 IS 4 BP 562 EP 572 DI 10.1016/j.envsoft.2009.09.008 PG 11 WC Computer Science, Interdisciplinary Applications; Engineering, Environmental; Environmental Sciences SC Computer Science; Engineering; Environmental Sciences & Ecology GA 553FB UT WOS:000274350400017 ER PT J AU Savard, K Sarrazin, M Dodard, SG Monteil-Rivera, F Kuperman, RG Hawari, J Sunahara, GI AF Savard, Kathleen Sarrazin, Manon Dodard, Sabine G. Monteil-Rivera, Fanny Kuperman, Roman G. Hawari, Jalal Sunahara, Geoffrey I. TI ROLE OF SOIL INTERSTITIAL WATER IN THE ACCUMULATION OF HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE IN THE EARTHWORM EISENIA ANDREI SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Hexahydro-1,3,5-trinitro-1,3,5-triazine; Bioaccumulation; Bioavailability; Bioconcentration; Equilibrium partitioning ID SANDY LOAM SOIL; HETEROCYCLIC EXPLOSIVES RDX; ORGANIC-CHEMICALS; BIOACCUMULATION; TOXICITY; REPRODUCTION; HMX; BIOAVAILABILITY; OLIGOCHAETA; SURVIVAL AB The uptake of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) from soil by the earthworm Eisenia andrei was examined by using the equilibrium partitioning (EqP) theory and a three-compartment model including soil (S), interstitial water (IW), and earthworms (E). The RDX concentrations were measured using U.S. Environmental Protection Agency (U.S. EPA) Method 8330A and high-performance liquid chromatography (HPLC). The S-IW studies were conducted using four natural soils with contrasting physicochemical properties that were hypothesized to affect the bioavailability of RDX. Each soil was amended with nominal RDX concentrations ranging from 1 to 10,000 mg/kg. The HPLC analysis showed that the IW extracted from soil was saturated with RDX at 80 mg/kg or greater soil concentrations. The calculated S-IW coefficient (K(p)) values for RDX ranged from 0.4 to 1.8 ml/g soil, depending on the soil type, and were influenced by the organic matter content. In the IW-E studies, earthworms were exposed to nonlethal RDX concentrations in aqueous media. The uptake of RDX by the earthworms correlated well (r(2) = 0.99) with the dissolved RDX concentrations. For the E-S studies, earthworms were exposed to RDX-amended soils used in the S-IW studies. The bioconcentration factors (BCF; ratios of E-to-IW RDX concentrations) were relatively constant (similar to 5) up to 80 mg/kg soil RDX concentrations, which encompass the RDX saturation limit in the interstitial water of the tested soils. At this concentration range, the RDX uptake from interstitial water was likely dominated by passive diffusion and could be used as an indicator of bioavailability. Other mechanisms may be involved at greater RDX soil concentrations. Environ. Toxicol. Chem. 2010;29:998-1005. (C) 2009 SETAC C1 [Savard, Kathleen; Sarrazin, Manon; Dodard, Sabine G.; Monteil-Rivera, Fanny; Hawari, Jalal; Sunahara, Geoffrey I.] Natl Res Council Canada, Biotechnol Res Inst, Montreal, PQ H4P 2R2, Canada. [Kuperman, Roman G.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Sunahara, GI (reprint author), Natl Res Council Canada, Biotechnol Res Inst, 6100 Royalmount Ave, Montreal, PQ H4P 2R2, Canada. EM geoffrey.sunahara@cnrc-nrc.gc.ca RI Kuperman, Roman/D-4297-2009; OI Kuperman, Roman/0000-0001-5344-1633 FU U.S. Department of Defense [ER-1256, ER-1416]; Defence Research and Development Canada, Valcartier FX This research project was supported by the U.S. Department of Defense through the Strategic Environmental Research and Development Program (SERDP Projects ER-1256 and ER-1416) and by the Defence Research and Development Canada, Valcartier. The authors offer special thanks to Sonia Thiboutot and Guy Ampleman for their continuing support of this project and to Louise Paquet for her analytical support. This publication was assigned National Research Council-Canada NRC 50001. NR 42 TC 4 Z9 4 U1 1 U2 15 PU SETAC PRESS PI PENSACOLA PA 1010 N 12TH AVE, PENSACOLA, FL 32501-3367 USA SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD APR PY 2010 VL 29 IS 4 BP 998 EP 1005 DI 10.1002/etc.113 PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 582NI UT WOS:000276604100029 PM 20821531 ER PT J AU Ignaccolo, M Latka, M West, BJ AF Ignaccolo, M. Latka, M. West, B. J. TI Detrended fluctuation analysis of scaling crossover effects SO EPL LA English DT Article ID HEART-RATE DYNAMICS; TIME-SERIES AB Detrended fluctuation analysis (DFA) is one of the most frequently used fractal time series algorithms. DFA has also become the tool of choice for analysis of the short-time fluctuations despite the fact that its validity in this domain has never been demonstrated. We adopt an Ornstein-Uhlenbeck Langevin equation to generate a time series which exhibits short-time power-law scaling and incorporates the fundamental property of physiological control systems-negative feedback. To determine the scaling exponent, we derive the analytical expressions for the standard deviation of the solution X(t) of this equation using both the ensemble of statistically independent trajectories and the ensemble obtained by partitioning a single trajectory. The latter approach is used in DFA and many other physiological applications. Surprisingly, the formulas for the standard deviations are different for these two ensembles. We demonstrate that the partitioning amounts to building up deterministic trends that satisfy the "trend + signal" decomposition assumption which is characteristic of DFA. Consequently, the dependence of the rms of DFA residuals F(tau) on the length tau of data window is the same for both ensembles. The growth of F(tau) is significantly different from that of the standard deviation of X(t). While the DFA estimate of the short-time scaling exponent is correct, the polynomial detrending delays the approach of F(tau) to the asymptotic value by as much as an order of magnitude. This delay may underlie the gradual change of the DFA scaling index typically observed in time series that exhibit crossover between the short- and long-time scaling. Copyright (C) EPLA, 2010 C1 [Latka, M.] Wroclaw Univ Technol, Inst Biomed Engn, PL-50370 Wroclaw, Poland. [Ignaccolo, M.] Duke Univ, Dept Phys, Durham, NC 27708 USA. [West, B. J.] USA, Res Off, Div Math, Res Triangle Pk, NC 27709 USA. RP Ignaccolo, M (reprint author), Wroclaw Univ Technol, Inst Biomed Engn, Wybrzeze Wyspianskiego 27, PL-50370 Wroclaw, Poland. EM Miroslaw.Latka@pwr.wroc.pl FU U.S. Army Research Office FX MI thanks the U.S. Army Research Office for support of this research. We thank a referee for suggesting the two-walker interpretation of STE averaging. NR 29 TC 6 Z9 6 U1 0 U2 3 PU EPL ASSOCIATION, EUROPEAN PHYSICAL SOCIETY PI MULHOUSE PA 6 RUE DES FRERES LUMIERE, MULHOUSE, 68200, FRANCE SN 0295-5075 EI 1286-4854 J9 EPL-EUROPHYS LETT JI EPL PD APR PY 2010 VL 90 IS 1 AR 10009 DI 10.1209/0295-5075/90/10009 PG 6 WC Physics, Multidisciplinary SC Physics GA 615FJ UT WOS:000279118900009 ER PT J AU Kimberley, J Lambros, J Chasiotis, I Pulskamp, J Polcawich, R Dubey, M AF Kimberley, J. Lambros, J. Chasiotis, I. Pulskamp, J. Polcawich, R. Dubey, M. TI A Hybrid Experimental/Numerical Investigation of the Response of Multilayered MEMS Devices to Dynamic Loading SO EXPERIMENTAL MECHANICS LA English DT Article DE MEMS; Dynamic loading; SHPB; High speed imaging; Failure ID RELIABILITY AB In order to probe the mechanical response of microelectromechanical systems (MEMS) subjected to dynamic loading, a modified split Hopkinson pressure bar was used to load MEMS devices at accelerations ranging from 10(3)-10(5) g. Multilayer beams consisting of a PZT film sandwiched between two metal electrodes atop an elastic layer of silicon dioxide were studied because of their relevance to active MEMS devices. Experiments were conducted using the modified split Hopkinson pressure bar to quantify the effects of dynamic loading amplitude, duration, and temporal profile on the failure of the multilayered cantilever beams. Companion finite element simulations of these beams, informed by experimental measurements, were conducted to shed light into the deformation of the multilayered beams. Results of the numerical simulations were then coupled with independent experimental measurements of failure stress in order to predict the material layer at which failure initiation occurred, and the associated time to failure. High-speed imaging was also used to capture the first real-time images of MEMS structures responding to dynamic loading and successfully compare the recorded failure event with those predicted numerically. C1 [Kimberley, J.; Lambros, J.; Chasiotis, I.] Univ Illinois, Urbana, IL 61801 USA. [Pulskamp, J.; Polcawich, R.; Dubey, M.] USA, Res Labs, Adelphi, MD USA. RP Lambros, J (reprint author), Univ Illinois, Urbana, IL 61801 USA. EM lambros@illinois.edu FU Army Research Office (ARO) [W911NF-05-1-0063]; National Science Foundation [CMS-0555787]; US Department of Energy [DEFG02-91-ER45439] FX The authors would like to acknowledge the support of the Army Research Office (ARO) under the Grant W911NF-05-1-0063 with Dr. Bruce LaMattina as the program manager, and the support by the National Science Foundation under Grant CMS-0555787. Electron microscopy was carried out in the Center for Microanalysis of Materials, University of Illinois, which is partially supported by the US Department of Energy under grant DEFG02-91-ER45439. The authors would also like to thank Richard Piekarz, John Conrad, and Joel Martin of the Army Research Laboratory along with Prashant Ranade of General Technical Services for their assistance in the fabrication of the MEMS devices. NR 19 TC 3 Z9 3 U1 0 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0014-4851 J9 EXP MECH JI Exp. Mech. PD APR PY 2010 VL 50 IS 4 BP 527 EP 544 DI 10.1007/s11340-009-9259-0 PG 18 WC Materials Science, Multidisciplinary; Mechanics; Materials Science, Characterization & Testing SC Materials Science; Mechanics GA 568TY UT WOS:000275547000011 ER PT J AU Jackson, WM Nesti, LJ Tuan, RS AF Jackson, Wesley M. Nesti, Leon J. Tuan, Rocky S. TI Potential therapeutic applications of muscle-derived mesenchymal stem and progenitor cells SO EXPERT OPINION ON BIOLOGICAL THERAPY LA English DT Review DE MPCs; MSCs; regenerative medicine; skeletal muscle stem cells; tissue engineering ID HUMAN SKELETAL-MUSCLE; HUMAN TRABECULAR BONE; VIVO GENE-THERAPY; MYOGENIC ENDOTHELIAL-CELLS; MORPHOGENETIC PROTEIN 4; REGENERATIVE MEDICINE; IMMUNOLOGICAL-PROPERTIES; TECHNOLOGY INSIGHT; CARTILAGE REPAIR; DENTAL-TISSUES AB Importance of the field: Mesenchymal adult stem cells have properties that make them attractive for use in tissue engineering and regenerative medicine. They are inherently plastic, enabling them to differentiate along different lineages, and promote wound healing and regeneration of surrounding tissues by modulating immune and inflammatory responses, promoting angiogenesis and secreting other trophic factors. Unlike embryonic stem cells, clinical uses of mesenchymal stem cells are not encumbered by ethical considerations or legal restrictions. Areas covered in this review: We discuss skeletal muscle as a source of mesenchyma I stem and progenitor cells by reviewing their biology and current applications in tissue engineering and regenerative medicine. This paper covers literature from the last 5 - 10 years. What the reader will gain: Skeletal muscle is a plentiful source of mesenchymal stem and progenitor cells. This tissue may be obtained via routine biopsy or collection after surgical debridement. We describe the biology of these cells and provide an overview of therapeutic applications currently being developed to take advantage of their regenerative properties. Take home message: There is potential for stem and progenitor cells derived from skeletal muscle to be incorporated in clinical interventions, either as a cellular therapy to modify the natural history of disease or as a component of engineered tissue constructs that can replace diseased or damaged tissues. C1 [Tuan, Rocky S.] Univ Pittsburgh, Sch Med, Ctr Cellular & Mol Engn, Dept Orthopaed Surg, Pittsburgh, PA 15232 USA. [Jackson, Wesley M.; Nesti, Leon J.; Tuan, Rocky S.] NIAMSD, NIH, Cartilage Biol & Orthopaed Branch, Dept Hlth & Human Serv, Bethesda, MD 20892 USA. [Jackson, Wesley M.; Nesti, Leon J.] NIAMSD, NIH, Dept Hlth & Human Serv, Clin & Expt Orthopaed Lab, Bethesda, MD 20892 USA. [Nesti, Leon J.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. RP Tuan, RS (reprint author), Univ Pittsburgh, Sch Med, Ctr Cellular & Mol Engn, Dept Orthopaed Surg, 450 Technol Dr,Room 221, Pittsburgh, PA 15232 USA. EM rst13@pitt.edu FU Military Amputee Research Program [P05-A011]; Comprehensive Neurosciences Program [CNP-2008-CR01]; NIH [Z01 AR41131] FX LJ Nesti has received funding from the Military Amputee Research Program #P05-A011 and Comprehensive Neurosciences Program #CNP-2008-CR01. RS Tuan received NIH intramural Support (Z01 AR41131). NR 117 TC 40 Z9 47 U1 4 U2 20 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1471-2598 J9 EXPERT OPIN BIOL TH JI Expert Opin. Biol. Ther. PD APR PY 2010 VL 10 IS 4 BP 505 EP 517 DI 10.1517/14712591003610606 PG 13 WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Research & Experimental Medicine GA 582CQ UT WOS:000276573500003 PM 20218920 ER PT J AU Weiss, BM Kuehl, WM AF Weiss, Brendan M. Kuehl, W. Michael TI Advances in understanding monoclonal gammopathy of undetermined significance as a precursor of multiple myeloma SO EXPERT REVIEW OF HEMATOLOGY LA English DT Review DE MGUS; monoclonal gammopathy of undetermined significance; multiple myeloma; pathogenesis ID LIGHT-CHAIN RATIO; INDEPENDENT RISK-FACTOR; PLASMA-CELL DISORDERS; SIGNIFICANCE MGUS; NATURAL-HISTORY; WORKING GROUP; 1ST-DEGREE RELATIVES; MARROW ANGIOGENESIS; PRIMARY AMYLOIDOSIS; PESTICIDE EXPOSURE AB Monoclonal gammopathy of undetermined significance (MGUS) affects at least 3% of the population above the age of 50 and is the precursor to multiple myeloma (MM), an incurable malignancy of plasma cells. Recent advances in MGUS include: an improved understanding of the pathogenesis of MGUS and its progression to MM, involving molecular events intrinsic to the malignant plasma cell as well as the microenvironment; novel techniques to assess risk for progression to MM using serum-free light-chain analysis and immunophenotyping; and a renewed interest in chemoprevention of MM. In the future, continued improvement in our understanding of MGUS will lead to the development of better biomarkers for prognosis and therapies for chemoprevention of MM. C1 [Weiss, Brendan M.] Walter Reed Army Med Ctr, Hematol Oncol Serv, Washington, DC 20307 USA. [Kuehl, W. Michael] NCI, Genet Branch, Ctr Canc Res, Bethesda, MD 20892 USA. RP Weiss, BM (reprint author), Walter Reed Army Med Ctr, Hematol Oncol Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM brendan.weiss@us.army.mil FU NIH, National Cancer Institute, Center for Cancer Research; Binding Site, Inc., Birmingham, UK FX The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Army, nor the US Government. W Michael Kuehl is supported by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research. Other research support was provided by The Binding Site, Inc., Birmingham, UK. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. NR 75 TC 3 Z9 3 U1 1 U2 5 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1747-4086 J9 EXPERT REV HEMATOL JI Expert Rev. Hematol. PD APR PY 2010 VL 3 IS 2 BP 165 EP 174 DI 10.1586/EHM.10.13 PG 10 WC Hematology SC Hematology GA 687TT UT WOS:000284801500010 PM 20473362 ER PT J AU Andaya, JM Hernandez, CA Sato, AK Uyehara, CFT AF Andaya, January May Hernandez, Claudia A. Sato, Aileen K. Uyehara, Catherine F. T. TI Sex differences in estrogen receptor mediation of vasopressin synthesis and release in rats chronically exposed to alcohol SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Andaya, January May] Univ Hawaii Manoa, Honolulu, HI 96822 USA. [Andaya, January May; Hernandez, Claudia A.; Sato, Aileen K.; Uyehara, Catherine F. T.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675503692 ER PT J AU Andersen, NE Karl, JP Diaz, JE Cable, SJ Williams, KW Rood, JC Young, AJ Lieberman, HR McClung, JP AF Andersen, Nancy Ellen Karl, J. Philip Diaz, Jennifer E. Cable, Sonya J. Williams, Kelly W. Rood, Jennifer C. Young, Andrew J. Lieberman, Harris R. McClung, James P. TI Changes in vitamin D status of female Soldiers during basic combat training SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Andersen, Nancy Ellen; Karl, J. Philip; Diaz, Jennifer E.; Young, Andrew J.; Lieberman, Harris R.; McClung, James P.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [Cable, Sonya J.; Williams, Kelly W.] Directorate Basic Combat Training, Ft Jackson, SC USA. [Rood, Jennifer C.] Pennington Biomed Res Ctr, Baton Rouge, LA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675501508 ER PT J AU Baer, L Pidcoke, H Wu, XW Silliman, D Walters, T Tou, J Wolf, S Wade, C AF Baer, Lisa Pidcoke, Heather Wu, Xiaowu Silliman, David Walters, Thomas Tou, Janet Wolf, Steven Wade, Charles TI Effects of Daily Insulin Treatment on Bone in Rats Following Severe Burn and Disuse SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Baer, Lisa; Pidcoke, Heather; Wu, Xiaowu; Silliman, David; Walters, Thomas; Wolf, Steven; Wade, Charles] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Tou, Janet] W Virginia Univ, Morgantown, WV 26506 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675501793 ER PT J AU Carbone, JW Pasiakos, SM Vislocky, LM Anderson, JM Rodriguez, NR AF Carbone, John W. Pasiakos, Stefan M. Vislocky, Lisa M. Anderson, Jeffrey M. Rodriguez, Nancy R. TI Moderate energy deprivation increases caspase-3 activity and fractional breakdown rate in human skeletal muscle SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Carbone, John W.] Eastern Michigan Univ, Sch Hlth Sci, Ypsilanti, MI 48197 USA. [Pasiakos, Stefan M.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [Vislocky, Lisa M.; Anderson, Jeffrey M.; Rodriguez, Nancy R.] Univ Connecticut, Storrs, CT USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675504543 ER PT J AU Darlington, DN Kheirabadi, BS Martini, WZ Dubick, MA AF Darlington, Daniel Norman Kheirabadi, Bijan S. Martini, Wenjun Z. Dubick, Michael A. TI Hemorrhagic-induced acidosis does not affect recombinant Factor VIIa (rFVIIa) function in Swine SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Darlington, Daniel Norman; Kheirabadi, Bijan S.; Martini, Wenjun Z.; Dubick, Michael A.] USA, Inst Surg Res, DCRP, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675505878 ER PT J AU DeGroot, DW Ely, MR Karl, JP Young, AJ AF DeGroot, David W. Ely, Matthew R. Karl, J. Philip Young, Andrew J. TI Altered substrate utilization during sequential short-term under- and over-feeding SO FASEB JOURNAL LA English DT Meeting Abstract C1 [DeGroot, David W.; Ely, Matthew R.; Karl, J. Philip; Young, Andrew J.] USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675501171 ER PT J AU Dubick, MA Mase, VJ Barr, JL Grubbs, DL Roe, JL Walters, TJ AF Dubick, Michael A. Mase, Vincent J., Jr. Barr, Johnny L. Grubbs, Dana L. Roe, Janet L. Walters, Thomas J. TI Effect of skeletal muscle ischemia-reperfusion (I/R) post-conditioning (Post C) on antioxidant status in rats SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Dubick, Michael A.; Mase, Vincent J., Jr.; Barr, Johnny L.; Grubbs, Dana L.; Roe, Janet L.; Walters, Thomas J.] USA, Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675501536 ER PT J AU Gribok, AV Rumpler, WV Hoyt, R Buller, M AF Gribok, Andrei V. Rumpler, William V. Hoyt, Reed Buller, Mark TI A method to estimate instantaneous rates of gas exchange in indirect calorimetry SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Gribok, Andrei V.; Rumpler, William V.] Beltsville Human Nutr Res Ctr, Food Intake & Energy Regulat Lab, Beltsville, MD USA. [Hoyt, Reed; Buller, Mark] USA, Biophys & Biomed Modeling Div, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675505220 ER PT J AU Hammamieh, R Jett, M AF Hammamieh, Rasha Jett, Marti TI Systems biology approaches to characterize exposures to infectious agents SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Hammamieh, Rasha; Jett, Marti] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675504300 ER PT J AU Jackson, SJT Venema, RC Murphy, LL Singletary, KW Young, AJ AF Jackson, Steven J. T. Venema, Richard C. Murphy, Laura L. Singletary, Keith W. Young, Andrew J. TI Curcumin modulates hemeoxygenase-1, eNOS, and endothelial cell cycle progression SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Jackson, Steven J. T.; Young, Andrew J.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [Venema, Richard C.] Med Coll Georgia, Vasc Biol Ctr, Augusta, GA 30912 USA. [Murphy, Laura L.] So Illinois Univ, Dept Physiol, Carbondale, IL 62901 USA. [Singletary, Keith W.] Univ Illinois, Urbana, IL 61801 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675500429 ER PT J AU Karl, JP Lieberman, HR Cable, SJ Williams, KW Young, AJ McClung, JP AF Karl, J. Philip Lieberman, Harris R. Cable, Sonya J. Williams, Kelly W. Young, Andrew J. McClung, James P. TI Relationships between iron status, serum hepcidin and inflammation in female Soldiers during military training SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Karl, J. Philip; Lieberman, Harris R.; Young, Andrew J.; McClung, James P.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Cable, Sonya J.; Williams, Kelly W.] Directorate Basic Combat Training, Ft Jackson, SC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675500396 ER PT J AU Kenefick, RW Cheuvront, SN Ely, BR Palombo, LJ Sawka, MN AF Kenefick, Robert W. Cheuvront, Samuel N. Ely, Brett R. Palombo, Laura J. Sawka, Michael N. TI High Skin Temperature Accentuates Aerobic Performance Degradation when Hypohydrated SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Kenefick, Robert W.; Cheuvront, Samuel N.; Ely, Brett R.; Palombo, Laura J.; Sawka, Michael N.] USA, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675501115 ER PT J AU Kenefick, RW Ely, BR Cheuvront, SN Palombo, LJ Sawka, MN AF Kenefick, Robert W. Ely, Brett R. Cheuvront, Samuel N. Palombo, Laura J. Sawka, Michael N. TI Effects of Skin Temperature on Hypohydration Mediated Hemodynamic Responses to Submaximal Exercise. SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Kenefick, Robert W.; Ely, Brett R.; Cheuvront, Samuel N.; Palombo, Laura J.; Sawka, Michael N.] USA, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675500530 ER PT J AU Kirby, S Norris, J Cerasoli, D Bahnson, B AF Kirby, Stephen Norris, Joseph Cerasoli, Douglas Bahnson, Brian TI Engineering Platelet-Activating Factor Acetylhydrolase as a Catalytic Bioscavenger for Organophosphorus Compounds SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Kirby, Stephen; Norris, Joseph; Cerasoli, Douglas] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD USA. [Kirby, Stephen; Bahnson, Brian] Univ Delaware, Newark, DE USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675504103 ER PT J AU Klemcke, HG Rose, R Oh, T Calderon, ML AF Klemcke, Harold G. Rose, Rajiv Oh, Thomas Calderon, Mariam L. TI Survival time after hemorrhage (STaH) in inbred rats with known blood volumes SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Klemcke, Harold G.; Rose, Rajiv; Oh, Thomas; Calderon, Mariam L.] USA, Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675505367 ER PT J AU Lieberman, HR Kellogg, MD Lesher, LL Kramer, FM AF Lieberman, Harris R. Kellogg, Mark D. Lesher, Larry L. Kramer, F. Matthew TI Improved Overall Mood during Military Basic Combat Training (BCT), including lower Anxiety, Fatigue and Depression, is associated with changes in nutritional and metabolic state SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Lieberman, Harris R.; Kellogg, Mark D.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [Lesher, Larry L.; Kramer, F. Matthew] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675502877 ER PT J AU Lorenzo, S Sawka, MN Minson, CT AF Lorenzo, Santiago Sawka, Michael N. Minson, Christopher T. TI Heat acclimation induces peripheral modifications in cutaneous vascular function in humans SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Lorenzo, Santiago; Minson, Christopher T.] Univ Oregon, Eugene, OR 97403 USA. [Sawka, Michael N.] USA, Thermal & Mt Div, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675500733 ER PT J AU Lorenzo, S Miller, D Halliwill, JR Sawka, MN Minson, CT AF Lorenzo, Santiago Miller, Danielle Halliwill, John R. Sawka, Michael N. Minson, Christopher T. TI Heat acclimation improves central cardiac function and performance variables in cool environments SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Lorenzo, Santiago; Miller, Danielle; Halliwill, John R.; Minson, Christopher T.] Univ Oregon, Eugene, OR 97403 USA. [Sawka, Michael N.] USA, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675500421 ER PT J AU Martens, ME AF Martens, Margaret E. TI Mechanisms of Mitochondrial Dysfunction Induced by Sulfur Mustard in Human Epidermal Keratinocytes (HEK) SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Martens, Margaret E.] USA, Med Res Inst Chem Def, Physiol & Immunol Branch, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675505127 ER PT J AU Martens, ME Olivera, DS AF Martens, Margaret E. Olivera, Dorian S. TI Impaired Energy Metabolism in Airway Epithelial Cells Exposed to the Industrial Toxicant Phosgene SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Martens, Margaret E.] USA, Med Res Inst Chem Def, Physiol & Immunol Branch, Aberdeen Proving Ground, MD 21010 USA. [Olivera, Dorian S.] USA, Med Res Inst Chem Def, Med Toxicol Branch, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675502685 ER PT J AU McClung, JP Andersen, NE Wiley, BC Marchitelli, LJ Hennigar, SR Young, AJ AF McClung, James P. Andersen, Nancy E. Wiley, Bryan C. Marchitelli, Louis J. Hennigar, Stephen R. Young, Andrew J. TI Iron deficiency does not cause obesity in adult rats SO FASEB JOURNAL LA English DT Meeting Abstract C1 [McClung, James P.; Andersen, Nancy E.; Wiley, Bryan C.; Marchitelli, Louis J.; Hennigar, Stephen R.; Young, Andrew J.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675500866 ER PT J AU McGraw, SM DeGroot, DW Ely, MR Karl, JP Young, AJ Lieberman, HR AF McGraw, Susan M. DeGroot, David W. Ely, Matthew R. Karl, James P. Young, Andrew J. Lieberman, Harris R. TI Effects on mood and satiety of 4 days of partial energy deficit (60%) or energy excess (150%) SO FASEB JOURNAL LA English DT Meeting Abstract C1 [McGraw, Susan M.; Ely, Matthew R.; Karl, James P.; Young, Andrew J.; Lieberman, Harris R.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [DeGroot, David W.] USA, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675503870 ER PT J AU Miller, SA Muhie, S Juibitu, M Moyler, C Hammamieh, R Jett, M AF Miller, Stacy-Ann Muhie, Seid Juibitu, Meskerem Moyler, Candace Hammamieh, Rasha Jett, Marti TI Gene Profiles of Host Biological Processes Targeted by Yersinia pestis SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Miller, Stacy-Ann; Muhie, Seid; Juibitu, Meskerem; Moyler, Candace; Hammamieh, Rasha; Jett, Marti] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675502891 ER PT J AU Moeckel-Cole, SA Zambraski, E Gordish-Dressman, H Hoffman, E Devaney, J Clarkson, P AF Moeckel-Cole, Stephanie Anne Zambraski, Edward Gordish-Dressman, Heather Hoffman, Eric Devaney, Joe Clarkson, Priscilla TI A Single Nucleotide Polymorphism (SNP) in Titin (TTN) Decreases Muscle Soreness and Strength Deficits after Eccentric Exercise in Women SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Moeckel-Cole, Stephanie Anne; Clarkson, Priscilla] Univ Massachusetts, Amherst, MA 01003 USA. [Zambraski, Edward] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Gordish-Dressman, Heather; Hoffman, Eric; Devaney, Joe] Med Genet Res Ctr, Washington, DC USA. NR 0 TC 0 Z9 0 U1 1 U2 5 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675501328 ER PT J AU Mu, TS Batts, SG Sato, A Hernandez, C Ichimura, W Lentz-Kapua, SL Uyehara, CFT AF Mu, Thornton Samuel Batts, Sherreen G. Sato, Aileen Hernandez, Claudia Ichimura, Wayne Lentz-Kapua, Sarah L. Uyehara, Catherine F. T. TI Renin-Angiotensin-Aldosterone System During Extracorporeal Membrane Oxygenation (ECMO) in a Pig Model of Septic Shock SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Mu, Thornton Samuel; Batts, Sherreen G.; Sato, Aileen; Hernandez, Claudia; Ichimura, Wayne; Lentz-Kapua, Sarah L.; Uyehara, Catherine F. T.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675505109 ER PT J AU Muhie, S Hammamieh, R Yang, D Jett, M AF Muhie, Seid Hammamieh, Rasha Yang, David Jett, Marti TI Staphylococcus Enterotoxin B induced Host Response Signatures in the Presence and Absence of Battlefield-like Stress SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Muhie, Seid; Yang, David; Jett, Marti] Georgetown Univ, Washington, DC USA. [Muhie, Seid; Hammamieh, Rasha; Jett, Marti] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675502843 ER PT J AU Norris, J Chung, M Smith, JR Kirby, S AF Norris, Joseph Chung, Myra Smith, J. Richard Kirby, Stephen TI Engineering Human Paraoxonase-1 Double Mutants to Hydrolyze Organophosphorus Compounds SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Norris, Joseph; Chung, Myra; Smith, J. Richard; Kirby, Stephen] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675502838 ER PT J AU Oh, T Calderon, ML Klemcke, HG AF Oh, Taesung Calderon, M. L. Klemcke, H. G. TI Brain stem heme oxygenase 1 (HO-1) mRNA expression in inbred rat strains after severe hemorrhage SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Oh, Taesung; Calderon, M. L.; Klemcke, H. G.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675506623 ER PT J AU Polykratis, IA Rubal, BJ Sondeen, JL DeLorenzo, RA Dubick, MA AF Polykratis, Irene Amy Rubal, Bernard J. Sondeen, Jill L. DeLorenzo, Robert A. Dubick, Michael A. TI The hypercoagulability of initial intraosseous aspirates SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Polykratis, Irene Amy] Intstitute Surg Res, Damage Control & Resuscitat Program, Ft Sam Houston, TX USA. [Rubal, Bernard J.; DeLorenzo, Robert A.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Sondeen, Jill L.; Dubick, Michael A.] USA, Inst Surg Res, Damage Control & Resuscitat Program, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675502559 ER PT J AU Rastogi, A Yang, J Wang, XY Bynum, J Stavchansky, S Bowman, PD AF Rastogi, Ashish Yang, John Wang, Xinyu Bynum, James Stavchansky, Salomon Bowman, Phillip D. TI Induction of Hypoxia Inducible Factor 1 Alpha (HIF1 alpha) by Caffeic Acid Phenethyl Ester (CAPE) and Caffeic Acid Phenethyl Amide (CAPA) in Mouse Skin Fibroblasts SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Rastogi, Ashish; Yang, John; Wang, Xinyu; Bynum, James; Bowman, Phillip D.] USA, Inst Surg Res, San Antonio, TX USA. [Rastogi, Ashish; Yang, John; Wang, Xinyu; Stavchansky, Salomon] Univ Texas Austin, Austin, TX 78712 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675505230 ER PT J AU Rose, R Oh, T Calderon, M Klemcke, H AF Rose, Rajiv Oh, Taesung Calderon, Mariam Klemcke, Harold TI Inter- and intra-strain variability for survival time after hemorrhage in inbred rats SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Rose, Rajiv; Oh, Taesung; Calderon, Mariam; Klemcke, Harold] USA, Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675507115 ER PT J AU Shih, TM Skovira, JW McDonough, JH AF Shih, Tsung-Ming Skovira, Jacob W. McDonough, John H. TI Specificity of Brain Structures Sensitive to Initiating Nerve Agent-Induced Seizures SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Shih, Tsung-Ming; Skovira, Jacob W.; McDonough, John H.] USA, Div Res, Med Res Inst Chem Defn, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675506460 ER PT J AU Shih, TM Koenig, JA Tarzia, KA Skovira, JW McDonough, JH AF Shih, Tsung-Ming Koenig, Jeffrey A. Tarzia, Kristin A. Skovira, Jacob W. McDonough, John H. TI Protective Effects of Midazolam and MMB-4 plus Atropine Sulfate in Nerve Agent Intoxication SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Shih, Tsung-Ming; Koenig, Jeffrey A.; Tarzia, Kristin A.; Skovira, Jacob W.; McDonough, John H.] USA, Div Res, Med Res Inst Chem Defn, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675500102 ER PT J AU Siller-Jackson, AJ Bowman, PD Wenke, JC Bynum, JA Hammamieh, R AF Siller-Jackson, Arlene J. Bowman, Phillip D. Wenke, Joseph C. Bynum, James A. Hammamieh, Rasha TI Temporal Gene Expression Profiling of Bone Repair in a Rat Calvarial Defect SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Siller-Jackson, Arlene J.; Bowman, Phillip D.; Wenke, Joseph C.; Bynum, James A.] USAISR, Ft Sam Houston, TX USA. [Hammamieh, Rasha] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675507494 ER PT J AU Smith, TJ Anderson, D Sikes, A Margolis, LM Young, AJ AF Smith, Tracey J. Anderson, Danielle Sikes, Anthony Margolis, Lee M. Young, Andrew J. TI Persistence of Lactobacillus Reuteri DSM17938 in the Human Intestinal Tract SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Smith, Tracey J.; Margolis, Lee M.; Young, Andrew J.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [Anderson, Danielle; Sikes, Anthony] Natick Soldier Res, Combat Feeding Directorate, Ctr Dev & Engn, Natick, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675501718 ER PT J AU Srinivasan, S Miller, SA Shupp, JW Crosby, MC Hammamieh, R Jett, M AF Srinivasan, Seshamalini Miller, Stacy-Ann Shupp, Jeffrey W. Crosby, Margaret C. Hammamieh, Rasha Jett, Marti TI Differential Gene Expression of Cutaneous Cells Upon Exposure to Staphylococcal Enterotoxin B (SEB) Superantigen SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Srinivasan, Seshamalini; Miller, Stacy-Ann; Shupp, Jeffrey W.; Crosby, Margaret C.; Hammamieh, Rasha; Jett, Marti] Walter Reed Army Inst Res, Silver Spring, MD USA. [Shupp, Jeffrey W.] Washington Hosp Ctr, Burn Ctr, Washington, DC USA. NR 0 TC 0 Z9 0 U1 2 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675504786 ER PT J AU Stauss, HM Liaboe, FO Leon, LR Kregel, KC AF Stauss, Harald M. Liaboe, Frederick O. Leon, Lisa R. Kregel, Kevin C. TI Effect of exertional vs. passive heat stress on diurnal rhythms of hemodynamic parameters and parasympathetic modulation of cardiac function SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Stauss, Harald M.; Liaboe, Frederick O.; Kregel, Kevin C.] Univ Iowa, Iowa City, IA USA. [Leon, Lisa R.] USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675503166 ER PT J AU Stoltenburg, AA Kemmer, TM Gidvani-Diaz, V Lougee, D Coello, M Amador, WE Lynch, J Thanapura, P AF Stoltenburg, Ashley Ann Kemmer, Teresa M. Gidvani-Diaz, Vinod Lougee, Douglas Coello, Miguel Amador, Wilmer E. Lynch, Julia Thanapura, Pravara TI Mapping of anemia prevalence among Honduran children ages 6-60 months using global positioning system data SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Stoltenburg, Ashley Ann; Kemmer, Teresa M.; Thanapura, Pravara] S Dakota State Univ, Brookings, SD 57007 USA. [Gidvani-Diaz, Vinod; Lougee, Douglas] San Antonio Mil Pediat Ctr, San Antonio, TX USA. [Coello, Miguel; Amador, Wilmer E.] Joint Task Force Bravo, Soto Cano, Honduras. [Lynch, Julia] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675505687 ER PT J AU Urso, ML Wang, RB Zambraski, EJ Liang, BT AF Urso, Maria Laina Wang, Ruibo Zambraski, Edward J. Liang, Bruce T. TI Adenosine A3 Receptor Agonists (A3RA) Induce Favorable Alterations in the MMP/TIMP Response in Skeletal Muscle Following Traumatic Injury SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Urso, Maria Laina; Zambraski, Edward J.] USA, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. [Wang, Ruibo; Liang, Bruce T.] Univ Connecticut, Ctr Hlth, Pat & Jim Calhoun Cardiol Ctr, Farmington, CT USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675500853 ER PT J AU Uyehara, CFT Sato, AK Hernandez, CA Ichimura, WM Batts, S Mu, TS Andaya, JM AF Uyehara, Catherine F. T. Sato, Aileen K. Hernandez, Claudia A. Ichimura, Wayne M. Batts, Sherreen Mu, Thornton S. Andaya, January M. TI Extracorporeal Membrane Oxygenation (ECMO) Does Not Restore Renal Autoregulation in Endotoxin-Induced Acute Renal Failure SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Uyehara, Catherine F. T.; Sato, Aileen K.; Hernandez, Claudia A.; Ichimura, Wayne M.; Batts, Sherreen; Mu, Thornton S.; Andaya, January M.] Tripler Army Med Ctr, Tripler, HI USA. [Andaya, January M.] Univ Hawaii, Honolulu, HI 96822 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675506470 ER PT J AU Wang, XY Bynum, J Stavchansky, S Dubick, M Hackman, R Keen, C Bowman, P AF Wang, Xinyu Bynum, James Stavchansky, Salomon Dubick, Michael Hackman, Robert Keen, Carl Bowman, Phillip TI Cytoprotection of human endothelial cells from oxidative stress by polyphenols: the role of gene expression versus direct antioxidant effect SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Wang, Xinyu; Bynum, James; Dubick, Michael; Bowman, Phillip] USA, Inst Surg Res, San Antonio, TX USA. [Wang, Xinyu; Stavchansky, Salomon] Univ Texas Austin, Div Pharmaceut, Austin, TX 78712 USA. [Hackman, Robert; Keen, Carl] Univ Calif Davis, Davis, CA 95616 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675504360 ER PT J AU Wang, XY Bynum, J Stavchansky, S Bowman, P AF Wang, Xinyu Bynum, James Stavchansky, Salomon Bowman, Phillip TI Network Analysis of the Cytoprotective Effect of CDDO-IM against Oxidant Stress in Human Umbilical Vein Endothelial Cells (HUVEC) SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Wang, Xinyu; Bynum, James; Bowman, Phillip] USA, Inst Surg Res, San Antonio, TX USA. [Wang, Xinyu; Stavchansky, Salomon] Univ Texas Austin, Div Pharmaceut, Austin, TX 78712 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675504221 ER PT J AU Wu, XW Xiao, YF Baer, LA Chen, YD Wolf, SE Walters, TJ Wade, CE AF Wu, Xiaowu Xiao, Yufei Baer, Lisa A. Chen, Yidong Wolf, Steven E. Walters, Thomas J. Wade, Charles E. TI The Gene Profile of the Skeletal Muscle in Response to Burn and Hindlimb Unloading SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Wu, Xiaowu; Baer, Lisa A.; Wolf, Steven E.; Walters, Thomas J.; Wade, Charles E.] USA, Inst Surg Res, San Antonio, TX USA. [Wu, Xiaowu; Xiao, Yufei; Chen, Yidong; Wolf, Steven E.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675504066 ER PT J AU Zindel, K Wiewel, K Hammamieh, R Jett, M Mendis, C AF Zindel, Kristin Wiewel, Kurstin Hammamieh, Rasha Jett, Marti Mendis, Chanaka TI Effect of SEB induced cell death in DU 145 cells SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Zindel, Kristin; Wiewel, Kurstin; Mendis, Chanaka] Univ Wisconsin, Dept Chem & Engn Phys, Platteville, WI USA. [Hammamieh, Rasha; Jett, Marti] Walter Reed Army Inst Res, Dept Mol Pathol, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675503210 ER PT J AU Henne, MB Bundorf, MK AF Henne, Melinda B. Bundorf, M. Kate TI The effects of competition on assisted reproductive technology outcomes SO FERTILITY AND STERILITY LA English DT Article DE Assisted reproductive technology; competition; multiple birth rates; patient selection ID IN-VITRO FERTILIZATION; HOSPITAL MARKET-STRUCTURE; MULTIPLE GESTATION; INSURANCE-COVERAGE; PRACTICE PATTERNS; EMBRYO-TRANSFER; INFERTILITY; COUPLES; BIRTHS; PREGNANCIES AB Objective: To evaluate the relationship between competition among fertility clinics and assisted reproductive technology (ART) treatment outcomes, particularly multiple births. Design: Using clinic-level data from 1995 to 2001, we examined the relationship between competition and clinic-level ART outcomes and practice patterns. Setting: National database registry. Patient(s): Clinics performing ART. Intervention(s): The number of clinics within a 20-mile (32.19-km) radius of a given clinic. Main Outcome Measure(s): Clinic-level births, singleton births, and multiple births per ART cycle; multiple births per ART birth; average number of embryos transferred per cycle; and the proportion of cycles for women under age 35 years. Result(s): The number of competing clinics is not strongly associated with ART birth and multiple birth rates. Relative to clinics with no competitors, the rate of multiple births per cycle is lower (-0.03 percentage points) only for clinics with more than 15 competitors. Embryo transfer practices are not statistically significantly associated with the number of competitors. Clinic-level competition is strongly associated with patient mix. The proportion of cycles for patients under 35 years old is 6.4 percentage points lower for clinics with more than 15 competitors than for those with no competitors. Conclusion(s): Competition among fertility clinics does not appear to increase rates of multiple births from ART by promoting more aggressive embryo transfer decisions. (Fertil Steril(R) 2010;93:1820-30. (C) 2010 by American Society for Reproductive Medicine.) C1 [Henne, Melinda B.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Henne, Melinda B.] Stanford Univ, Sch Med, Ctr Hlth Policy Primary Care & Outcomes Res, Stanford, CA 94305 USA. [Bundorf, M. Kate] Stanford Univ, Sch Med, Dept Hlth Res & Policy, Stanford, CA 94305 USA. RP Henne, MB (reprint author), Walter Reed Army Med Hosp, Dept Obstet & Gynecol, 6900 Georgia Ave NW,Bldg 2,Room 2J06, Washington, DC 20307 USA. EM redbbdoc@aol.com FU Agency for Healthcare Research and Quality (AHRQ); Institute for Research on Women and Gender at Stanford University FX Supported by funding from a National Research Service Award training grant from the Agency for Healthcare Research and Quality (AHRQ) and the Iris M. Litt Fund from the Institute for Research on Women and Gender at Stanford University. NR 41 TC 9 Z9 10 U1 1 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD APR PY 2010 VL 93 IS 6 BP 1820 EP 1830 DI 10.1016/j.fertnstert.2008.02.159 PG 11 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 583LS UT WOS:000276678100014 PM 18442821 ER PT J AU Jumaily, JS Noordzij, JP Dukas, AG Lee, SL Bernet, VJ Payne, RJ McLeod, IK Hier, MP Black, MJ Kerr, PD Raffaelli, M Bellantone, R Lombardi, CP Dietrich, MS AF Jumaily, Jeffrey Saad Noordzij, J. Pieter Dukas, Alex G. Lee, Stephanie L. Bernet, Victor J. Payne, Richard J. McLeod, Ian K. Hier, Michael P. Black, Martin J. Kerr, Paul D. Raffaelli, Marco Bellantone, Rocco Lombardi, Celestino P. Dietrich, Mary S. TI PREDICTION OF HYPOCALCEMIA AFTER USING 1-TO 6-HOUR POSTOPERATIVE PARATHYROID HORMONE AND CALCIUM LEVELS: AN ANALYSIS OF POOLED INDIVIDUAL PATIENT DATA FROM 3 OBSERVATIONAL STUDIES SO HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK LA English DT Article DE thyroidectomy; hypocalcemia; parathyroid hormone (PTH); postoperative management; rapid parathyroid hormone assay ID POST-THYROIDECTOMY HYPOCALCEMIA; POSTTHYROIDECTOMY HYPOCALCEMIA; SURGERY; ASSAY; HYPOPARATHYROIDISM; MANAGEMENT; DISCHARGE AB Background. Parathyroid hormone (PTH) levels up to 6 hours postthyroidectomy have been shown to have excellent predictive power in determining hypocalcemia. In this study, we investigate the usefulness of combining calcium and PTH to increase the predictive power. Methods. Individual patient data were obtained from 3 studies (152 patients) that fulfilled our criteria (using PTH assay within hours postthyroidectomy to predict symptomatic hypocalcemia). Results. Changes in combined PTH and calcium threshold levels checked 1 to 6 hours after thyroidectomy were excellent in predicting postoperative hypocalcemia. A decrease in PTH of 60%, coupled with a simultaneous decrease in calcium of 10%, 5 to 6 hours postoperatively resulted in a sensitivity and specificity of 100%. However, combined PTH and calcium threshold changes were not significantly better than using PTH threshold changes alone. Conclusions. Threshold changes in serum calcium and PTH, checked hours after surgery, can be used together to accurately predict whether a patient will become hypocalcemic after thyroidectomy. (C) 2009 Wiley Periodicals, Inc. Head Neck 32: 427-434, 2010 C1 [Jumaily, Jeffrey Saad; Noordzij, J. Pieter; Dukas, Alex G.] Boston Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, Boston, MA 02215 USA. [Lee, Stephanie L.] Boston Univ, Med Ctr, Sect Endocrinol Diabet & Nutr, Boston, MA USA. [Bernet, Victor J.] Walter Reed Army Med Ctr, Dept Endocrinol, Washington, DC 20307 USA. [Payne, Richard J.] McGill Univ, Jewish Gen Hosp, Dept Otolaryngol Head & Neck Surg, Montreal, PQ H3T 1E2, Canada. [McLeod, Ian K.] Walter Reed Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Washington, DC 20307 USA. [Hier, Michael P.; Black, Martin J.; Kerr, Paul D.] Univ Manitoba, Dept Otolaryngol, Winnipeg, MB, Canada. [Raffaelli, Marco; Bellantone, Rocco; Lombardi, Celestino P.] Univ Cattolica Sacro Cuore, Dept Surg, Div Endocrine Surg, Rome, Italy. [Dietrich, Mary S.] Vanderbilt Univ, Sch Nursing, Nashville, TN 37240 USA. [Dietrich, Mary S.] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA. RP Noordzij, JP (reprint author), Boston Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, Boston, MA 02215 USA. EM noordzij@bu.edu OI Dukas, Alex/0000-0003-1300-4038 NR 34 TC 19 Z9 19 U1 0 U2 4 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1043-3074 J9 HEAD NECK-J SCI SPEC JI Head Neck-J. Sci. Spec. Head Neck PD APR PY 2010 VL 32 IS 4 BP 427 EP 434 DI 10.1002/hed.21199 PG 8 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 576HV UT WOS:000276136000002 PM 19780054 ER PT J AU Labrie, JE Keiser, PB AF Labrie, Joseph E., III Keiser, Paul B. TI Whole cell vaccination for meningococcus Lessons from an idea for which time has gone SO HUMAN VACCINES LA English DT Editorial Material DE Neisseria meningitidis; endotoxin; vaccine; outer membrane vesicle; lipopolysaccharide ID PROPHYLACTIC VACCINATION; EPIDEMIC MENINGITIS C1 [Labrie, Joseph E., III; Keiser, Paul B.] Walter Reed Army Inst Res, Dept Meningococcal Vaccines, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. RP Keiser, PB (reprint author), Walter Reed Army Inst Res, Dept Meningococcal Vaccines, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. EM paul.keiser@us.army.mil NR 46 TC 3 Z9 3 U1 0 U2 0 PU LANDES BIOSCIENCE PI AUSTIN PA 1002 WEST AVENUE, 2ND FLOOR, AUSTIN, TX 78701 USA SN 1554-8600 J9 HUM VACCINES JI Hum. Vaccines PD APR PY 2010 VL 6 IS 4 BP 360 EP 365 PG 6 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA 652GH UT WOS:000281990800015 PM 20372072 ER PT J AU Ehasz, EJ Goyette, TM Giles, RH Nixon, WE AF Ehasz, Elizabeth J. Goyette, Thomas M. Giles, Robert H. Nixon, William E. TI High-Resolution Frequency Measurements of Far-Infrared Laser Lines SO IEEE JOURNAL OF QUANTUM ELECTRONICS LA English DT Article DE Far-infrared (FIR) laser; gas laser; molecular laser; submillimeter-wave laser; terahertz source AB The frequency of four previously reported far-infrared laser lines have been measured to an accuracy of 100 kHz. These laser lines were measured using a heterodyne system which allowed for more accurate measurement. The four far-infrared laser lines which originated from Formic Acid (HCOOH), O-Deutero-Formic Acid (HCOOD), C-Deutero-Formic Acid (DCOOH), and Methyl Chloride (CH(3)Cl) were optically pumped by a highly stable, grating-tunable, CO(2) laser. Three of the far-infrared laser lines have been measured previously using Fabry-Perot cavities not typicaly known for their high accuracy. The fourth far-infrared laser line had been measured previously by heterodyne methods but under nonoptimal conditions. The difference between the frequencies measured here and the listed frequencies for these laser lines ranged from 0.9 MHz to 3.9 GHz. C1 [Ehasz, Elizabeth J.; Goyette, Thomas M.; Giles, Robert H.] Univ Massachusetts Lowell, Submillimeter Wave Technol Lab, Lowell, MA 01854 USA. [Nixon, William E.] USA, Natl Ground Intelligence Ctr, Charlottesville, VA 22911 USA. RP Ehasz, EJ (reprint author), Univ Massachusetts Lowell, Submillimeter Wave Technol Lab, Lowell, MA 01854 USA. EM elizabeth_ehasz@student.uml.edu NR 14 TC 2 Z9 2 U1 1 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9197 J9 IEEE J QUANTUM ELECT JI IEEE J. Quantum Electron. PD APR PY 2010 VL 46 IS 4 BP 474 EP 477 DI 10.1109/JQE.2009.2036378 PG 4 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA 558GW UT WOS:000274730100007 ER PT J AU Cheng, SF Tom, K Thomas, L Pecht, M AF Cheng, Shunfeng Tom, Kwok Thomas, Larry Pecht, Michael TI A Wireless Sensor System for Prognostics and Health Management SO IEEE SENSORS JOURNAL LA English DT Article DE Cross-validation; prognostics and health management (PHM); radio frequency identification (RFID); sequential probability ratio test (SPRT); wireless sensor system ID ELECTRONICS AB This paper introduces a novel radio-frequency-based wireless sensor system and describes its prognostics and health management functions. The wireless sensor system includes a radio frequency identification sensor tag, a wireless reader, and diagnostic-prognostic software. The software uses the sequential probability ratio test with a cross-validation procedure to detect anomalies, assess degradation, and predict failures. The prognostic performance of the sensor system is demonstrated by a field application. C1 [Cheng, Shunfeng] Univ Maryland, CALCE, Prognost & Hlth Management Lab, College Pk, MD 20742 USA. [Tom, Kwok] USA, Res Lab, Adelphi, MD 20783 USA. [Thomas, Larry] EPrognost Syst LLC, Leander, TX 78641 USA. [Pecht, Michael] City Univ Hong Kong, Prognost & Hlth Management Ctr, Hong Kong, Hong Kong, Peoples R China. RP Cheng, SF (reprint author), Univ Maryland, CALCE, Prognost & Hlth Management Lab, College Pk, MD 20742 USA. EM chengsf@calce.umd.edu; kwok.tom@us.army.mil; Larry@eProgSys.com; pecht@calce.umd.edu OI Pecht, Michael/0000-0003-1126-8662 FU CALCE; Army Research Laboratory; United States Army FX We thank ePrognostic Systems LLC for providing the data and CALCE's sponsors, the Army Research Laboratory, and the United States Army SWORDS project, for providing us guidance and a platform for testing. NR 13 TC 31 Z9 37 U1 2 U2 28 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1530-437X J9 IEEE SENS J JI IEEE Sens. J. PD APR PY 2010 VL 10 IS 4 BP 856 EP 862 DI 10.1109/JSEN.2009.2035817 PG 7 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA 566LL UT WOS:000275371700012 ER PT J AU Liao, DH Sarabandi, K AF Liao, DaHan Sarabandi, Kamal TI On the Effective Low-Grazing Reflection Coefficient of Random Terrain Roughness for Modeling Near-Earth Radiowave Propagation SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Article DE Monte Carlo simulations; near-earth radiowave propagation; rough surfaces; volumetric perturbation method ID WAVE-PROPAGATION; SURFACE AB An investigation on the effects of terrain roughness on near-ground radiowave propagation is featured. In spite of the fact that a variety of analytical and numerical routines have been proposed by many workers for the general treatment of the scattering properties of rough surfaces, much disagreement remains in the solution of the problem for near-grazing scenarios. In striving to analytically describe the near-grazing propagation of signals from 2D and 3D radiators, an existing volumetric polarization current-based perturbation approach is exploited in this work to formulate closed-form expressions for the coherent rough surface reflection coefficients. Although the perturbation approach was originally intended for analyzing the scattering coefficients of a ground with scale of roughness much smaller than the wavelength, it is shown through Monte Carlo simulations that the effective reflection coefficients reported herein are applicable for near-ground path-loss prediction even when the surface variation (height) is on the order of a wavelength or more. C1 [Liao, DaHan; Sarabandi, Kamal] Univ Michigan, Radiat Lab, Ann Arbor, MI 48109 USA. RP Liao, DH (reprint author), USA, Res Lab, Adelphi, MD USA. EM liaod@umich.edu; saraband@eecs.umich.edu NR 19 TC 4 Z9 4 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-926X J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD APR PY 2010 VL 58 IS 4 BP 1315 EP 1324 DI 10.1109/TAP.2010.2041310 PG 10 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 579YX UT WOS:000276414500032 ER PT J AU Wijewarnasuriya, PS Chen, YP Brill, G Zandi, B Dhar, NK AF Wijewarnasuriya, Priyalal S. Chen, Yuanping Brill, Gregory Zandi, Bahram Dhar, Nibir K. TI High-Performance Long-Wavelength Infrared HgCdTe Focal Plane Arrays Fabricated on CdSeTe Compliant Si Substrates SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article DE CdSeTe; CdTe; compliant Si substrates; focal plane arrays (FPAs); HgCdTe; infrared (IR) detectors; long-wavelength IR; molecular beam epitaxy (MBE) ID MOLECULAR-BEAM EPITAXY; HG1-XCDXTE PHOTOVOLTAIC DETECTORS; REMOTE-SENSING APPLICATIONS; GROWTH; PHOTODIODES; CDZNTE/SI; QUALITY; DEFECTS; SI(211) AB At the U.S. Army Research Laboratory, a new ternary semiconductor system CdSe(x)Te(1-x)/Si(211) is being investigated as an alternative substrate to bulk-grown CdZnTe substrates for HgCdTe growth by molecular beam epitaxy. Long-wavelength (LW) photovoltaic devices fabricated on this compliant substrate material show diffusion limited performance at 78 K, indicating a high-quality material. The measured R(o)A at 78 K on lambda(co) = 10 mu m material is on the order of 340 Omega . cm(2). In addition to single devices, we have fabricated 256 x 256 2-D arrays with a 40-mu m pixel pitch on LW-HgCdTe grown on CdSe(x)Te(1-x)/Si(211) compliant substrates. The data show an excellent quantum efficiency operability of 99% at 78 K under a tactical background flux of 6.7 x 10(15) ph/cm(2)s. The most probable dark current at peak distribution is 5.5 x 10(9) e-/s and is very consistent with the measured R(o)A values from single devices. This work demonstrates that CdSe(x)Te(1-x)/Si(211) substrates provide a potential roadmap for more affordable robust third-generation focal plane arrays. C1 [Wijewarnasuriya, Priyalal S.; Chen, Yuanping; Brill, Gregory; Zandi, Bahram; Dhar, Nibir K.] USA, Res Lab, Adelphi, MD 20783 USA. RP Wijewarnasuriya, PS (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM priyalal.wijewarnasuriya@us.army.mil FU U.S. Department of Commerce [BS123456]; Dr. M. Tidrow of the Missile Defense Agency FX This work was supported in part by the U.S. Department of Commerce under Grant BS123456 and in part by Dr. M. Tidrow of the Missile Defense Agency. The review of this paper was arranged by Editor J. Tower. NR 19 TC 10 Z9 10 U1 0 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9383 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD APR PY 2010 VL 57 IS 4 BP 782 EP 787 DI 10.1109/TED.2010.2041511 PG 6 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA 574OB UT WOS:000275998500007 ER PT J AU Elliott, LR van Erp, JBF Redden, ES Duistermaat, M AF Elliott, Linda R. van Erp, Jan B. F. Redden, Elizabeth S. Duistermaat, Maaike TI Field-Based Validation of a Tactile Navigation Device SO IEEE TRANSACTIONS ON HAPTICS LA English DT Article DE Psychology; social and behavioral sciences; computer applications; design for wearability; user interfaces; information interfaces and representation (HCI); information technology and systems; military; computers in other systems; haptic I/O ID VIBROTACTILE; PERFORMANCE; DISPLAYS; SIGNALS; DESIGN; TORSO AB In this paper, we present three field-based evaluations of a tactile land navigation system. In Experiment 1, we transition from a laboratory setting to rugged terrain used to train US Army soldier land navigation. Navigation in this challenging terrain requires careful attention to one's surroundings. Participants navigated 3 waypoints along 600 meters through heavily wooded terrain, using 1) map and compass, 2) standard alpha-numeric handheld GPS device, and 3) the tactile GPS system, while also responding to radio requests for information. Experiment 2 used the same challenging terrain during night operations, where participants must also search for live and silhouette targets, using 1) handheld GPS device, 2) head-mounted map-based GPS, and 3) the tactile GPS system. In addition to navigating, participants searched for silhouette and live (human) targets. Experiment 3 had participants navigate with 1) a commercial GPS arrow display, 2) the tactile GPS system, and 3) both together. We conclude that tactile navigation displays can be used in strenuous outdoor environments and can outperform visual displays under conditions of high cognitive and visual workload. C1 [Elliott, Linda R.; Redden, Elizabeth S.] USA, Army Res Lab Field Element, Infantry Ctr, Ft Benning, GA 31905 USA. [van Erp, Jan B. F.; Duistermaat, Maaike] TNO Human Factors, NL-3769 ZG Soesterberg, Netherlands. RP Elliott, LR (reprint author), USA, Army Res Lab Field Element, Infantry Ctr, Bldg 4, Ft Benning, GA 31905 USA. EM Linda.r.elliott@us.army.mil; jan.vanerp@tno.nl; elizabeth.redden@us.army.mil; maaike.duistermaat@tno.nl OI van Erp, Jan/0000-0002-6511-2850 FU US Army FX This work was supported by an Advanced Technology Objective for enhanced situational understanding for dismount infantry soldiers of the US Army. The views, opinions, and/or findings contained in this paper are those of the authors and should not be construed as an official Department of the Army position, policy, or decision unless so designated by other documentation. NR 49 TC 22 Z9 22 U1 1 U2 4 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1939-1412 EI 2329-4051 J9 IEEE T HAPTICS JI IEEE Trans. Haptics PD APR-JUN PY 2010 VL 3 IS 2 BP 78 EP 87 DI 10.1109/ToH.2010.3 PG 10 WC Computer Science, Cybernetics SC Computer Science GA 749MB UT WOS:000289470300002 PM 27788115 ER PT J AU Tribble, DR Baqar, S Scott, DA Oplinger, ML Trespalacios, F Rollins, D Walker, RI Clements, JD Walz, S Gibbs, P Burg, EF Moran, AP Applebee, L Bourgeois, AL AF Tribble, David R. Baqar, Shahida Scott, Daniel A. Oplinger, Michael L. Trespalacios, Fernando Rollins, David Walker, Richard I. Clements, John D. Walz, Steven Gibbs, Paul Burg, Edward F., III Moran, Anthony P. Applebee, Lisa Bourgeois, A. Louis TI Assessment of the Duration of Protection in Campylobacter jejuni Experimental Infection in Humans SO INFECTION AND IMMUNITY LA English DT Article ID GUILLAIN-BARRE-SYNDROME; CLINICAL-FEATURES; IMMUNE-RESPONSE; DENDRITIC CELLS; PHASE VARIATION; RAW-MILK; IN-VIVO; CHILDREN; THAILAND; LIPOOLIGOSACCHARIDE AB A human Campylobacter jejuni infection model provided controlled exposure to assess vaccine efficacy and investigate protective immunity for this important diarrheal pathogen. A well-characterized outbreak strain, C. jejuni 81-176, was investigated using a volunteer experimental infection model to evaluate the dose range and duration of protection. Healthy Campylobacter-seronegative adults received C. jejuni strain 81-176 via oral inoculation of 10(5), 10(7), or 10(9) CFU (5 adults/dose), which was followed by clinical and immunological monitoring. Based on dose range clinical outcomes, the 10(9)-CFU dose (n = 31) was used to assess homologous protection at 28 to 49 days (short-term veterans [STV]; n = 8) or 1 year (long-term veterans [LTV]; n = 7) after primary infection. An illness dose effect was observed for naive subjects (with lower doses, 40 to 60% of the subjects were ill; with the 10(9)-CFU dose, 92% of the subjects were ill) along with complete protection for the STV group and attenuated illness for the LTV group (57%). Partial resistance to colonization was seen in STV (25% of the subjects were not infected; 3-log-lower maximum excretion level). Systemic and mucosal immune responses were robust in naive subjects irrespective of the dose or the severity of illness. In contrast, in STV there was a lack of circulating antibody-secreting cells (ASC), reflecting the local mucosal effector responses. LTV exhibited comparable ASC responses to primary infection, and anamnestic fecal IgA responses likely contributed to self-resolving illness prior to antibiotic treatment. Campylobacter antigen-dependent production of gamma interferon by peripheral blood mononuclear cells was strongly associated with protection from illness, supporting the hypothesis that TH1 polarization has a primary role in acquired immunity to C. jejuni. This study revealed a C. jejuni dose-related increase in campylobacteriosis rates, evidence of complete short-term protection that waned with time, and immune response patterns associated with protection. C1 [Tribble, David R.; Baqar, Shahida; Scott, Daniel A.; Rollins, David; Walz, Steven; Burg, Edward F., III; Applebee, Lisa; Bourgeois, A. Louis] USN, Med Res Ctr, Silver Spring, MD USA. [Oplinger, Michael L.; Trespalacios, Fernando; Gibbs, Paul] USA, Med Res Inst Infect Dis, Frederick, MD USA. [Clements, John D.] Tulane Univ, Sch Med, New Orleans, LA 70112 USA. [Walker, Richard I.] Antex Biol, Gaithersburg, MD USA. [Moran, Anthony P.] Natl Univ Ireland, Galway, Ireland. RP Tribble, DR (reprint author), Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Dept Prevent Med & Biometr, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM dtribble@usuhs.mil FU [643807A.849.D.A0002] FX This work was supported by Work Unit no. 643807A.849.D.A0002. NR 55 TC 28 Z9 28 U1 0 U2 10 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD APR PY 2010 VL 78 IS 4 BP 1750 EP 1759 DI 10.1128/IAI.01021-09 PG 10 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 570FA UT WOS:000275656400034 PM 20086085 ER PT J AU Weintrob, AC Roediger, MP Barber, M Summers, A Fieberg, AM Dunn, J Seldon, V Leach, F Huang, XZ Nikolich, MP Wortmann, GW AF Weintrob, Amy C. Roediger, Mollie P. Barber, Melissa Summers, Amy Fieberg, Ann M. Dunn, James Seldon, Venus Leach, Fluryanne Huang, Xiao-Zhe Nikolich, Mikeljon P. Wortmann, Glenn W. TI Natural History of Colonization with Gram-Negative Multidrug-Resistant Organisms among Hospitalized Patients SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID TERM-CARE FACILITY; MULTIRESISTANT ACINETOBACTER-BAUMANNII; STAPHYLOCOCCUS-AUREUS; ESCHERICHIA-COLI; PSEUDOMONAS-AERUGINOSA; CALCOACETICUS COMPLEX; DIGESTIVE-TRACT; CANCER-PATIENTS; RISK-FACTORS; ICU PATIENTS AB OBJECTIVE. To determine the anatomic sites and natural history of colonization with gram-negative multidrug-resistant organisms (MDROs). DESIGN. Prospective, longitudinal cohort study. SETTING. Walter Reed Army Medical Center, a 236-bed tertiary care center in Washington, DC. PATIENTS. Deployed subjects (ie, inpatients medically evacuated from Iraq or Afghanistan) or nondeployed subjects admitted to the same hospital. METHODS. Consenting patients had 6 anatomic sites cultured every 3 days for 2 weeks and then weekly. Gram-negative organisms resistant to 3 or more classes of antibiotics were considered MDROs. Isolates were genotyped using pulsed-field gel electrophoresis. Clinical data, data on antibiotic use, and clinical culture results were collected. RESULTS. Of 60 deployed subjects, 14 (23%) were colonized with an MDRO at admission, and 13 (22%) had incident colonization during hospitalization. The groin was the most sensitive anatomic site for detecting MDRO colonization, and all but one subject remained colonized for the duration of their hospitalization. Sixty percent of subjects with incident Acinetobacter colonization and 25% of subjects with incident Klebsiella colonization had strains that were related to those isolated from other subjects. Of 60 nondeployed subjects, 5 (8%) were colonized with an MDRO at admission; all had recent healthcare contact, and 1 nondeployed subject had an isolate related to a strain recovered from a deployed subject. CONCLUSIONS. Colonization with gram-negative MDROs is common among patients with war-related trauma admitted to a military hospital and also occurs among nondeployed patients with recent healthcare contact. The groin is the most sensitive anatomic site for active surveillance, and spontaneous decolonization is rare. C1 [Weintrob, Amy C.; Barber, Melissa] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Huang, Xiao-Zhe; Nikolich, Mikeljon P.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Weintrob, Amy C.; Dunn, James; Seldon, Venus; Leach, Fluryanne; Wortmann, Glenn W.] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. [Summers, Amy] Walter Reed Army Med Ctr, Microbiol Serv, Washington, DC 20307 USA. [Roediger, Mollie P.; Fieberg, Ann M.] Univ Minnesota, Div Biostat, Minneapolis, MN USA. RP Weintrob, AC (reprint author), Walter Reed Army Med Ctr, Infect Dis Serv, 6900 Georgia Ave,NW,Bldg 2,Ward 63,Room 6312, Washington, DC 20307 USA. EM Amy.Weintrob@us.army.mil FU NIAID NIH HHS [Y1-AI-5072] NR 35 TC 37 Z9 40 U1 2 U2 6 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD APR PY 2010 VL 31 IS 4 BP 330 EP 337 DI 10.1086/651304 PG 8 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 562DW UT WOS:000275030600003 PM 20175687 ER PT J AU Aldous, WK Co, EMA AF Aldous, Wade K. Co, Edgie-Mark A. TI Factors Associated with Recovery of Multidrug-Resistant Bacteria in a Combat Support Hospital in Iraq SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Editorial Material C1 [Aldous, Wade K.] Brooke Army Med Ctr, Dept Pathol, Ft Sam Houston, TX 78234 USA. [Aldous, Wade K.; Co, Edgie-Mark A.] Ibn Sina Hosp, Combat Support Hosp 10, Lab Serv, Baghdad, Iraq. [Co, Edgie-Mark A.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. RP Aldous, WK (reprint author), Brooke Army Med Ctr, Dept Pathol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM wade.aldous@us.army.mil RI Co, Edgie-Mark/A-9142-2011 NR 8 TC 2 Z9 2 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD APR PY 2010 VL 31 IS 4 BP 425 EP 427 DI 10.1086/651302 PG 3 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 562DW UT WOS:000275030600019 PM 20184421 ER PT J AU Levin, AO Carpenter, KM Fowler, JM Brothers, BM Andersen, BL Maxwell, GL AF Levin, Anna O. Carpenter, Kristen M. Fowler, Jeffrey M. Brothers, Brittany M. Andersen, Barbara L. Maxwell, G. Larry TI Sexual Morbidity Associated With Poorer Psychological Adjustment Among Gynecological Cancer Survivors SO INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER LA English DT Article DE Sexual morbidity; Gynecological cancers; Survivorship; Quality of life; Psychological adjustment ID LONG-TERM ADJUSTMENT; EARLY-STAGE BREAST; QUALITY-OF-LIFE; SCALE CES-D; CERVICAL-CANCER; OVARIAN-CANCER; PSYCHOEDUCATIONAL INTERVENTION; ONCOLOGY-GROUP; EVENT SCALE; WOMEN AB Objectives: Sexual morbidity is a distressing and undertreated problem in gynecological cancer survivorship known to occur early and persist well beyond the period of physical recovery. Although often studied as a separate domain, sexuality represents an integral component of psychological adjustment and quality of life (QoL) that is adversely affected by cancer treatments. The present study tests the association between sexual morbidity, and adverse psychological adjustment and QoL outcomes. Methods: A cross-sectional design was used. The participants were gynecological (cervical, endometrial, ovarian, and vulvar) cancer survivors who were partnered (N = 186), whose cancer was diagnosed 2 to 10 years previously, and who were at least 6 months post any cancer therapy. Most had been found to have early-stage disease (70%) and were treated with hysterectomy (77%), chemotherapy (43%), and/or radiotherapy (23%). Sexual morbidity was operationalized as a multidimensional construct including sexual behavior, sexual functioning, and subjective sexual satisfaction, assessed by patient self-report. Outcomes included self-reported depressive symptoms, traumatic stress symptoms, cancer-specific stress, stress about body changes, and QoL. Nurse-rated of performance status and disruptive signs/symptoms of treatment toxicity, as well as relevant sociodemographic and disease variables were collected as potential controls. Results: Hierarchical multiple regression analyses tested sexual morbidity as a predictor of poor outcomes. All statistical models were significant, accounting for 12% to 53% of the variance in psychological adjustment/QoL. Sexual morbidity covaried with worsened depressive symptoms, body change stress, and psychological QoL beyond the negative contributions of (older) age, (poorer) performance status, and (greater) fatigue. Notably, disease and treatment variables were not statistically significant correlates of psychological adjustment or QoL. Conclusions: These findings suggest that prevention or treatment of sexual morbidity might foster improved psychological adjustment/ QoL. Given the high rates of sexual morbidity in this population and the connection between sexuality and broader psychological adjustment/ QoL, there is a clear need for better integration of sexuality rehabilitation into routine clinical care. C1 [Levin, Anna O.; Carpenter, Kristen M.; Andersen, Barbara L.] Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA. [Fowler, Jeffrey M.] Ohio State Univ, Dept Obstet & Gynecol, Columbus, OH 43210 USA. [Fowler, Jeffrey M.; Brothers, Brittany M.; Andersen, Barbara L.] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA. [Maxwell, G. Larry] Walter Reed Army Med Ctr, Gynecol Dis Ctr, US Mil Canc Inst, Washington, DC 20307 USA. RP Carpenter, KM (reprint author), Ohio State Univ, Dept Psychol, Psychol Bldg 159,1885 Neil Ave, Columbus, OH 43210 USA. EM carpenter.292@osu.edu RI Carpenter, Kristen/I-1569-2013 FU Henry M. Jackson Foundation for Military Medicine [DODGCC-2004-1]; National Cancer Institute [R01CA92704, K05CA098133]; Graduate School of The Ohio State University FX This study was supported by the Henry M. Jackson Foundation for Military Medicine (DODGCC-2004-1), the National Cancer Institute (R01CA92704 and K05CA098133), and the Graduate School of The Ohio State University. NR 43 TC 30 Z9 30 U1 3 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1048-891X J9 INT J GYNECOL CANCER JI Int. J. Gynecol. Cancer PD APR PY 2010 VL 20 IS 3 BP 461 EP 470 DI 10.1111/IGC.0b013e3181d24ce0 PG 10 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 586IJ UT WOS:000276899900025 PM 20375814 ER PT J AU Shaffer, DN Ngetich, IK Bautista, CT Sawe, FK Renzullo, PO Scott, PT Kibaya, RM Imbuki, KO Michael, NL Birx, DL Wasunna, MK Robb, ML AF Shaffer, Douglas N. Ngetich, Ignatius K. Bautista, Christian T. Sawe, Frederick K. Renzullo, Philip O. Scott, Paul T. Kibaya, Rukia M. Imbuki, Kennedy O. Michael, Nelson L. Birx, Deborah L. Wasunna, Monique K. Robb, Merlin L. TI HIV-1 Incidence Rates and Risk Factors in Agricultural Workers and Dependents in Rural Kenya: 36-Month Follow-Up of the Kericho HIV Cohort Study SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE HIV; incidence; cohort; Kericho; Kenya ID REPRODUCTIVE AGE; KAGERA REGION; INFECTION; UGANDA; POPULATION; PREVALENCE; TRENDS; MALAWI; PROSTITUTES; TANZANIA AB Background: Incidence data from prospective cohort studies using rigorous laboratory methods are important in designing and evaluating HIV vaccine and therapeutic clinical trials and health care programs. We report 36-month HIV-1 incidence rates and demographic and psychosocial risks from the Kericho cohort in rural Kenya's southern Rift Valley Province. Methods: Thirty-six month, prospective, closed, observational cohort study of adult plantation workers and dependents followed biannually. HIV-1 incidence rates per 100 person-years (py) were calculated, and Cox regression analyses were used to estimate hazards ratios (HR) associated with seroconversion. Results: Two thousand four hundred volunteers (mean age +/- SD = 30.1 +/- 8.5 years; 36.5% women) participated. Twenty-nine new HIV cases were identified in year 1 of follow-up, which increased to cumulative totals of 49 and 63 cases in years 2 and 3, respectively. The corresponding 1-, 2-, and 3-year incidence rates were 1.41 [95% confidence interval (CI) = 0.95-2.02], 1.16 (95% CI = 0.86-1.54), and 1.00 (95% CI = 0.77-1.28) per 100 py. Risk factors associated with HIV seroconversion included the following: of the Luo tribe (HR = 3.31; 95% CI = 1.65-6.63), marriage more than once (HR = 2.83; 95% CI = 1.20-6.69), self-reported male circumcision (HR = 0.32; 95% CI = 0.17-0.60), history of sexually transmitted infection (HR = 2.40; 95% CI = 1.09-5.26), history of substance abuse during sex (HR = 2.44; 95% CI = 1.16-5.13), and history of transactional sex (HR = 3.30; 95% CI = 1.79-6.09). Conclusions: HIV-1 incidence rates were relatively low in adult plantation workers and dependents in rural Kenya. Cohorts including higher risk populations (eg, commercial sex workers) warrant consideration for regional HIV preventive vaccine trials. Even low incidence, well-described cohorts generate valuable epidemiological clinical trial data. C1 [Shaffer, Douglas N.; Ngetich, Ignatius K.; Bautista, Christian T.; Sawe, Frederick K.; Scott, Paul T.; Kibaya, Rukia M.; Imbuki, Kennedy O.; Michael, Nelson L.; Birx, Deborah L.; Robb, Merlin L.] US Mil HIV Res Program, Rockville, MD USA. [Shaffer, Douglas N.] Kenya Walter Reed Project HIV Program, US Army Med Res Unit, Kericho, Kenya. [Shaffer, Douglas N.; Scott, Paul T.; Michael, Nelson L.; Birx, Deborah L.] Walter Reed Army Inst Res, Rockville, MD USA. [Ngetich, Ignatius K.; Sawe, Frederick K.; Kibaya, Rukia M.; Imbuki, Kennedy O.; Wasunna, Monique K.] Kenya Govt Med Res Ctr, Kericho, Kenya. [Ngetich, Ignatius K.; Sawe, Frederick K.; Kibaya, Rukia M.; Imbuki, Kennedy O.; Wasunna, Monique K.] Kenya Govt Med Res Ctr, Nairobi, Kenya. [Bautista, Christian T.] Adv Mil Med Inc, Henry M Jackson Fdn, Rockville, MD USA. [Renzullo, Philip O.; Robb, Merlin L.] NIAID, Div Aids, NIH, Bethesda, MD 20892 USA. RP Shaffer, DN (reprint author), Kenya Walter Reed Project HIV Program, US Army Med Res Unit, Kericho, Kenya. EM dshaffer@wrp-kch.org RI Bautista, Christian/B-2812-2011 FU Walter Reed Army Institute of Research Institutional Research Board [RV142]; HIV and Malaria Cohort Study Among Plantation Workers and Adult Dependents in Kericho, Kenya, is funded through the United States Military HIV Research Program FX Supported by The Walter Reed Army Institute of Research Institutional Research Board human use protocol #855 (RV142); "HIV and Malaria Cohort Study Among Plantation Workers and Adult Dependents in Kericho, Kenya," is funded through the United States Military HIV Research Program (the Walter Reed Army Institute of Research and the Henry M. Jackson Foundation for the Advancement of Military Medicine Inc). NR 24 TC 5 Z9 5 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD APR 1 PY 2010 VL 53 IS 4 BP 514 EP 521 DI 10.1097/QAI.0b013e3181bcdae0 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 567YW UT WOS:000275486600013 PM 19855286 ER PT J AU Collamer, A Arroyo, R AF Collamer, Angelique Arroyo, Ramon TI Bone Marrow Hemophagocytosis Complicating Rheumatoid Arthritis SO JCR-JOURNAL OF CLINICAL RHEUMATOLOGY LA English DT Article C1 [Collamer, Angelique; Arroyo, Ramon] Brooke Army Med Ctr, Rheumatol Serv, Ft Sam Houston, TX 78234 USA. RP Collamer, A (reprint author), Brooke Army Med Ctr, Rheumatol Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM angelique.collamer@amedd.army.mil NR 2 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-1608 J9 JCR-J CLIN RHEUMATOL JI JCR-J. Clin. Rheumatol. PD APR PY 2010 VL 16 IS 3 BP 151 EP 151 DI 10.1097/RHU.0b013e3181d569e1 PG 1 WC Rheumatology SC Rheumatology GA 584CB UT WOS:000276726500015 PM 20375826 ER PT J AU Ashar, R Lewis, S Blazes, DL Chretien, JP AF Ashar, Raj Lewis, Sheri Blazes, David L. Chretien, J. P. TI Applying information and communications technologies to collect health data from remote settings: A systematic assessment of current technologies SO JOURNAL OF BIOMEDICAL INFORMATICS LA English DT Article DE Public health; Disease surveillance; Health surveillance; Developing nations; Data collection; Communications networks; Telecommunications; Mobile technologies ID DISEASE SURVEILLANCE AB Modern information and communications technologies (ICTs) are now so feature-rich and widely available that they can be used to "capture," or collect and transmit, health data from remote settings. Electronic data capture can reduce the time necessary to notify public health authorities, and provide important baseline information. A number of electronic health data capture systems based on specific ICTs have been developed for remote areas. We expand on that body of work by defining and applying an assessment process to characterize ICTs for remote-area health data capture. The process is based on technical criteria, and assesses the feasibility and effectiveness of specific technologies according to the resources and constraints of a given setting. Our characterization of current ICTs compares different system architectures for remote-area health data capture systems. Ultimately, we believe that our criteria-based assessment process will remain useful for characterizing future ICTs. (C) 2009 Elsevier Inc. All rights reserved. C1 [Ashar, Raj; Lewis, Sheri] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20723 USA. [Blazes, David L.] Armed Forces Hlth Surveillance Ctr, Div GEIS Operat, Silver Spring, MD USA. [Chretien, J. P.] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD USA. RP Ashar, R (reprint author), Johns Hopkins Univ, Appl Phys Lab, 11100 Johns Hopkins Rd, Laurel, MD 20723 USA. EM Raj.Ashar@jhuapl.edu NR 46 TC 6 Z9 6 U1 0 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1532-0464 J9 J BIOMED INFORM JI J. Biomed. Inform. PD APR PY 2010 VL 43 IS 2 BP 332 EP 341 DI 10.1016/j.jbi.2009.11.009 PG 10 WC Computer Science, Interdisciplinary Applications; Medical Informatics SC Computer Science; Medical Informatics GA 574SG UT WOS:000276012800017 PM 19961957 ER PT J AU Akers, KS Chaney, C Barsoumian, A Beckius, M Zera, W Yu, X Guymon, C Keen, EF Robinson, BJ Mende, K Murray, CK AF Akers, Kevin S. Chaney, Chris Barsoumian, Alice Beckius, Miriam Zera, Wendy Yu, Xin Guymon, Charles Keen, Edward F., III Robinson, Brian J. Mende, Katrin Murray, Clinton K. TI Aminoglycoside Resistance and Susceptibility Testing Errors in Acinetobacter baumannii-calcoaceticus Complex SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID GRAM-NEGATIVE BACILLI; INFECTIOUS-DISEASES SOCIETY; VITEK-2 SYSTEM; IDENTIFICATION; ANTIBIOTICS; MECHANISMS; GUIDELINES; COLISTIN; AMERICA; ENZYMES AB Antimicrobial resistance is depleting the pharmacopeia of agents clinically useful against Gram-negative bacilli. As the number of active agents diminishes, accurate susceptibility testing becomes critical. We studied the susceptibilities of 107 isolates of the Acinetobacter baumannii-calcoaceticus complex to amikacin, gentamicin, and tobramycin using disk diffusion, Etest, as well as the Phoenix, Vitek 2, and MicroScan automated systems, and compared the results to those obtained by broth microdilution. Genes encoding aminoglycoside-modifying enzymes (AMEs) were detected by multiplex PCR, and clonal relationships were determined by pulsed-field gel electrophoresis. Tobramycin was the most active aminoglycoside (27.1% of isolates were susceptible). Disk diffusion and Etest tended to be more accurate than the Vitek 2, Phoenix, and MicroScan automated systems; but errors were noted with all methods. The Vitek 2 instrument incorrectly reported that more than one-third of the isolates were susceptible to amikacin (a very major error). Isolates were polyclonal, with 26 distinct strains, and carried multiple AME genes unrelated to the strain type. The presence of the ant(2 '')-Ia gene was statistically associated with resistance to each aminoglycoside. The AME genotype accounted for the resistance profile observed in a minority of isolates, suggesting the involvement of multiple resistance mechanisms. Hospital pharmacy records indicated the preferential use of amikacin over other aminoglycosides in the burn intensive care unit, where aminoglycoside resistance is prevalent. The resistance in that unit did not correlate with a predominant strain, AME genotype, or total annual aminoglycoside consumption. Susceptibility to tobramycin increased, even though susceptible isolates carried AME genotypes predicting the inactivation of tobramycin. Determination of the relative contribution of multiple concurrent resistance mechanisms may improve our understanding of aminoglycoside resistance in the Acinetobacter baumannii-calcoaceticus complex. C1 [Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA. [Akers, Kevin S.; Chaney, Chris; Barsoumian, Alice; Murray, Clinton K.] San Antonio Mil Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. [Beckius, Miriam; Yu, Xin] San Antonio Mil Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. [Guymon, Charles] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Keen, Edward F., III; Robinson, Brian J.] San Antonio Mil Med Ctr, Dept Pathol, Ft Sam Houston, TX 78234 USA. [Keen, Edward F., III; Robinson, Brian J.] San Antonio Mil Med Ctr, Area Lab Serv, Ft Sam Houston, TX 78234 USA. [Mende, Katrin] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Clinton.Murray@amedd.army.mil RI Valle, Ruben/A-7512-2013 FU U.S. Armed Forces Health Surveillance Center (AFHSC); Division of Global Emerging Infections Surveillance and Response System (GEIS) Operations; Infectious Diseases Clinical Research Program (IDCRP) FX We gratefully acknowledge support from the U.S. Armed Forces Health Surveillance Center (AFHSC) Division of Global Emerging Infections Surveillance and Response System (GEIS) Operations and the Infectious Diseases Clinical Research Program (IDCRP). NR 37 TC 32 Z9 36 U1 0 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD APR PY 2010 VL 48 IS 4 BP 1132 EP 1138 DI 10.1128/JCM.02006-09 PG 7 WC Microbiology SC Microbiology GA 576OC UT WOS:000276153200016 PM 20107089 ER PT J AU Kajon, AE Dickson, LM Metzgar, D Houng, HS Lee, V Tan, BH AF Kajon, Adriana E. Dickson, Laura M. Metzgar, David Houng, Huo-Shu Lee, Vernon Tan, Boon-Huan TI Outbreak of Febrile Respiratory Illness Associated with Adenovirus 11a Infection in a Singapore Military Training Camp SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID GENOME TYPES; RECRUITS; DISEASE; PCR; HEALTHY; TYPE-11; ADULTS; GENE AB Outbreak cases of acute respiratory disease (ARD) associated with subspecies B2 human adenovirus 11a (HAdV-11a) infection were detected during 2005 in a military basic training camp in Singapore. The Singapore HAdV-11a strain is highly similar to other Asian strains of HAdV-11, including strain QS-DLL, which is responsible for the recently described 2006 outbreak of ARD in China. C1 [Kajon, Adriana E.; Dickson, Laura M.] LRRI, Program Infect Dis, Albuquerque, NM 87108 USA. [Metzgar, David] USN, Hlth Res Ctr, Dept Resp Dis Res, NHRC, San Diego, CA 92106 USA. [Houng, Huo-Shu] Walter Reed Army Inst Res, Dept Virus Dis, Silver Spring, MD 20910 USA. [Lee, Vernon] Biodef Ctr, Singapore 778910, Singapore. [Tan, Boon-Huan] Def Med & Environm Res Inst, Detect & Diagnost Lab, DSO Natl Labs, Singapore 117510, Singapore. RP Kajon, AE (reprint author), LRRI, Program Infect Dis, 2425 Ridgecrest Dr SE, Albuquerque, NM 87108 USA. EM akajon@lrri.org RI Valle, Ruben/A-7512-2013 FU Global Emerging Infections Surveillance and Response System; Division of the U.S. Armed Forces Health Surveillance Center; Henry M. Jackson Foundation for the Advancement of Military Medicine; Singapore Ministry of Defense FX Funding for this work was provided by the Global Emerging Infections Surveillance and Response System, a Division of the U.S. Armed Forces Health Surveillance Center, the Henry M. Jackson Foundation for the Advancement of Military Medicine, and the Singapore Ministry of Defense. We declare that no financial conflict of interest exists.; Views and opinions of and endorsements by the authors do not reflect those of the U.S. Army or the Department of Defense (DoD), the Department of the Navy, or the United States and Singapore governments. This research has been conducted in compliance with all applicable federal and international regulations governing the protection of human subjects in research (DoD protocol NHRC. 1999.0002). NR 36 TC 40 Z9 45 U1 0 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD APR PY 2010 VL 48 IS 4 BP 1438 EP 1441 DI 10.1128/JCM.01928-09 PG 4 WC Microbiology SC Microbiology GA 576OC UT WOS:000276153200064 PM 20129957 ER PT J AU Kwon, DH Bennett, W Herberg, S Bastone, P Pippig, S Rodriguez, NA Susin, C Wikesjo, UME AF Kwon, David H. Bennett, William Herberg, Samuel Bastone, Patrizia Pippig, Susanne Rodriguez, Nancy A. Susin, Cristiano Wikesjoe, Ulf M. E. TI Evaluation of an injectable rhGDF-5/PLGA construct for minimally invasive periodontal regenerative procedures: a histological study in the dog SO JOURNAL OF CLINICAL PERIODONTOLOGY LA English DT Article DE bone; cementum; GDF-5; periodontal ligament; periodontal regeneration; PLGA; tissue engineering ID BONE MORPHOGENETIC PROTEIN-2; GUIDED TISSUE REGENERATION; GROWTH/DIFFERENTIATION FACTOR-5; DIFFERENTIATION FACTORS; CLINICAL-APPLICATIONS; OSTEOGENIC PROTEIN; GENE-EXPRESSION; ALVEOLAR BONE; BETA FAMILY; RAT MODEL AB P>Aim To evaluate the injectability, biocompatibility, safety, and periodontal wound healing/regeneration following application of a novel bioresorbable recombinant human growth/differentiation factor-5 (rhGDF-5)/poly(lactic-co-glycolic acid) (PLGA) construct. Material and Methods Periodontal pockets (3 x 6 mm, width x depth) were surgically created over the buccal roots of the second and fourth mandibular pre-molars in eight adult Hound Labrador mongrel dogs. Surgeries including injection of the rhGDF-5/PLGA construct into the pockets were sequenced that four animals provided 2-/4-week and four animals 6-/8-week observations of sites receiving rhGDF-5/PLGA or serving as sham-surgery control. Results The rhGDF-5/PLGA construct was easy to prepare and apply. Approximately 0.2 ml (93 mu g rhGDF-5)/tooth was used. Clinical and radiographic healing was exemplary without adverse events. Healing was characterized by a non-specific connective tissue attachment, acellular/cellular cementum, periodontal ligament (PDL), bone regeneration, and a junctional epithelium. PLGA fragments were observed in 4/7, 2/8, and 1/8 sites at 2, 4, and 6 weeks, respectively. Associated inflammatory reactions exhibited no limiting effect on periodontal wound healing/regeneration. Root resorption/ankylosis was not observed. Bone formation showed apparent increased maturity (lamellar bone) at 6 weeks in sites receiving rhGDF-5/PLGA compared with the control. Both protocols exhibited significant increases in PDL, cementum, and bone regeneration over time, without significant differences between treatments. In time, PDL and cementum regeneration was twofold greater for the control at 4 weeks (p=0.04) while increased bone formation was observed at sites receiving rhGDF-5/PLGA (p < 0.01). Conclusions In conclusion, the rhGDF-5/PLGA construct appears to be a safe technology for injectable, ease-of-use application of rhGDF-5-stimulated periodontal wound healing/regeneration. Additional work to optimize the polymer carrier and rhGDF-5 release kinetics/dose might be required before evaluating the efficacy of this technology in clinical settings using minimally invasive approaches. C1 [Kwon, David H.; Bennett, William; Herberg, Samuel; Susin, Cristiano; Wikesjoe, Ulf M. E.] Med Coll Georgia, Sch Dent, Dept Periodont, LAPCR, Augusta, GA 30912 USA. [Kwon, David H.; Bennett, William; Herberg, Samuel; Susin, Cristiano; Wikesjoe, Ulf M. E.] Med Coll Georgia, Sch Dent, Dept Oral Biol, LAPCR, Augusta, GA 30912 USA. [Kwon, David H.] USA, Adv Educ Program Periodont, Ft Gordon, GA USA. [Bastone, Patrizia; Pippig, Susanne] Scil Technol GmbH, Martinsried, Germany. [Rodriguez, Nancy A.] Med Coll Georgia, Lab Anim Serv, Augusta, GA 30912 USA. RP Wikesjo, UME (reprint author), Med Coll Georgia, Sch Dent, Dept Periodont, LAPCR, AD 1430 1120 15th St, Augusta, GA 30912 USA. EM uwikesjo@mcg.edu RI Wikesjo, Ulf/A-4159-2009; Susin, Cristiano/B-9822-2008 OI Wikesjo, Ulf/0000-0003-1607-0583; NR 50 TC 28 Z9 28 U1 0 U2 3 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0303-6979 J9 J CLIN PERIODONTOL JI J. Clin. Periodontol. PD APR PY 2010 VL 37 IS 4 BP 390 EP 397 DI 10.1111/j.1600-051X.2010.01546.x PG 8 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 571CM UT WOS:000275728600010 PM 20447263 ER PT J AU Sharma, Y Xu, T Graf, WM Fobbs, A Sherwood, CC Hof, PR Allman, JM Manaye, KF AF Sharma, Yukti Xu, Tao Graf, Werner M. Fobbs, Archie Sherwood, Chet C. Hof, Patrick R. Allman, John M. Manaye, Kebreten F. TI Comparative Anatomy of the Locus Coeruleus in Humans and Nonhuman Primates SO JOURNAL OF COMPARATIVE NEUROLOGY LA English DT Article DE locus coeruleus; nonhuman primates; hominids; tyrosine hydroxylase; stereology ID TYROSINE-HYDROXYLASE; BEHAVING RATS; DOPAMINERGIC INNERVATION; BRAIN; NEURONS; NUMBER; EVOLUTION; CERULEUS; COMPLEX; MACAQUE AB The locus coeruleus (LC) is a dense cluster of neurons that projects axons throughout the neuroaxis and is located in the rostral pontine tegmentum extending from the level of the inferior colliculus to the motor nucleus of the trigeminal nerve. LC neurons are lost in the course of several neurodegenerative disorders, including Alzheimer's and Parkinson's diseases. In this study we used Nissl staining and tyrosine hydroxylase (TH) immunoreactivity to compare the human LC with that of closely related primate species, including great and lesser apes, and macaque monkeys. TH catalyzes the initial and rate-limiting step in catecholamine biosynthesis. The number of TH-immunoreactive (TH-ir) neurons was estimated in each species using stereologic methods. In the LC of humans the mean total number of TH-ir neurons was significantly higher compared to the other primates. Because the total number of TH-ir neurons in the LC was highly correlated with the species mean volume of the medulla oblongata, cerebellum, and neocortical gray matter, we conclude that much of the observed phylogenetic variation can be explained by anatomical scaling. Notably, the total number of LC neurons in humans was most closely predicted by the nonhuman allometric scaling relationship relative to medulla size, whereas the number of LC neurons in humans was considerably lower than predicted according to neocortex and cerebellum volume. J. Comp. Neurol. 518: 963-971,2010. (C) 2009 Wiley-Liss, Inc. C1 [Sharma, Yukti; Xu, Tao; Graf, Werner M.; Manaye, Kebreten F.] Howard Univ, Dept Physiol & Biophys, Coll Med, Washington, DC 20059 USA. [Fobbs, Archie] Walter Reed Army Med Ctr, Armed Forces Inst Pathol, Natl Museum Hlth & Med, Washington, DC 20307 USA. [Sherwood, Chet C.] George Washington Univ, Dept Anthropol, Washington, DC 20052 USA. [Hof, Patrick R.] Mt Sinai Sch Med, Dept Neurosci, New York, NY 10029 USA. [Hof, Patrick R.] New York Consortium Evolutionary Primatol, New York, NY USA. [Allman, John M.] CALTECH, Div Biol, Pasadena, CA 91125 USA. RP Manaye, KF (reprint author), Howard Univ, Dept Physiol & Biophys, Coll Med, 520 W St NW,Suite 2305, Washington, DC 20059 USA. EM kmanaye@howard.edu FU James McDonnell's Foundation [22002078]; NIH/NINDS [U54 NS39407, NS42867]; National Science Foundation [BCS-0515484, BCS-0549117, BCS-0827531, DGE-0801634] FX Grant sponsor: the James McDonnell's Foundation; Grant number: 22002078; Grant sponsor: NIH/NINDS; Grant numbers: U54 NS39407 (Specialized Neuroscience Research Program) and NS42867; Grant sponsor: National Science Foundation; Grant numbers: BCS-0515484, BCS-0549117, BCS-0827531, and DGE-0801634. NR 52 TC 8 Z9 8 U1 1 U2 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0021-9967 EI 1096-9861 J9 J COMP NEUROL JI J. Comp. Neurol. PD APR 1 PY 2010 VL 518 IS 7 BP 963 EP 971 DI 10.1002/cne.22249 PG 9 WC Neurosciences; Zoology SC Neurosciences & Neurology; Zoology GA 559OE UT WOS:000274834200002 PM 20127761 ER PT J AU Blomberg, SB Engel, RC Sawyer, R AF Blomberg, S. Brock Engel, Rozlyn C. Sawyer, Reid TI On the Duration and Sustainability of Transnational Terrorist Organizations SO JOURNAL OF CONFLICT RESOLUTION LA English DT Article DE conflict; terrorism; survival analysis AB This article aims to improve scholars' understanding of how transnational terrorist organizations emerge, survive, thrive, and eventually die. The authors use a data set that catalogues terrorist organizations and their attacks over time (the ITERATE database of thousands of terrorist events from 1968 through 2007) and merge those data with socioeconomic information about the environment in which each attack occurs. They use these data to trace the life cycle pattern of terrorist activity and the organizations that perpetrate them. They identify at least two types of terrorist organizations recidivists and one-hit wonders. The authors find that recidivist organizations, those that have repeatedly attacked,are less likely to survive once political and socioeconomic factors have been included. However, they find that sporadic or one-hit wonders are not easily deterred by socioeconomic factors, leaving open a role for counterinsurgency tactics. C1 [Blomberg, S. Brock] Claremont Mckenna Coll, Robert Day Sch Econ & Finance, Claremont, CA 91711 USA. [Engel, Rozlyn C.; Sawyer, Reid] US Mil Acad, Dept Social Sci, West Point, NY 10996 USA. RP Blomberg, SB (reprint author), Claremont Mckenna Coll, Robert Day Sch Econ & Finance, Claremont, CA 91711 USA. EM bblomberg@cmc.edu NR 19 TC 23 Z9 23 U1 1 U2 10 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0022-0027 J9 J CONFLICT RESOLUT JI J. Confl. Resolut. PD APR PY 2010 VL 54 IS 2 SI SI BP 303 EP 330 DI 10.1177/0022002709355431 PG 28 WC International Relations; Political Science SC International Relations; Government & Law GA 579KC UT WOS:000276367800006 ER PT J AU Escobedo, A Quinones, S Adame, M McClure, J Zubia, D Brill, G AF Escobedo, A. Quinones, S. Adame, M. McClure, J. Zubia, D. Brill, G. TI Characterization of Smooth CdTe(111) Films by the Conventional Close-Spaced Sublimation Technique SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE CdTe; II-VI semiconductors; close-spaced sublimation (CSS); scanning electron microscopy (SEM); x-ray diffraction (XRD) ID MOLECULAR-BEAM EPITAXY; CHEMICAL-VAPOR-DEPOSITION; CDTE LAYERS; SUBSTRATE ORIENTATION; PHASE EPITAXY; (111)B CDTE; SOLAR-CELLS; GROWTH; HGCDTE; GAAS AB Thin epitaxial CdTe films were grown on CdTe(111)B substrates by the close-spaced sublimation (CSS) technique and were characterized over a range of experimental parameters. The source temperature was varied between 480A degrees C and 540A degrees C, maintaining an average constant source-substrate temperature difference Delta T of similar to 130A degrees C. Helium was used as a carrier gas at pressures between 2 Torr and 10 Torr. Scanning electron microscopy (SEM) and x-ray diffraction (XRD) were used to analyze the film morphology and structure. Growth rates ranging from 1 mu m/h to 4 mu m/h were observed, based on profilometer thickness measurements. The addition of a pre-growth heat treatment step and post-growth annealing treatment resulted in smooth CdTe(111) films. An evolution in growth morphology was demonstrated with SEM images and film quality was confirmed with XRD. C1 [Escobedo, A.; Quinones, S.; Adame, M.; Zubia, D.] Univ Texas El Paso, Dept Elect & Comp Engn, El Paso, TX 79968 USA. [McClure, J.] Univ Texas El Paso, Dept Met & Mat Engn, El Paso, TX 79968 USA. [Brill, G.] USA, Res Lab, Adelphi, MD USA. RP Escobedo, A (reprint author), Univ Texas El Paso, Dept Elect & Comp Engn, El Paso, TX 79968 USA. EM stellaq@utep.edu RI Schaff, William/B-5839-2009; Brill, Gregory/G-4877-2013 FU Texas Instruments Foundation; National Science Foundation [0245071]; Forrest O. and Henrietta Lewis Foundation FX This material is based upon work supported by the Texas Instruments Foundation, the National Science Foundation under grant no. 0245071, and the Forrest O. and Henrietta Lewis Foundation. Support received by all NanoMaterials Integration Laboratory (NanoMIL) research members at The University of Texas at El Paso (UTEP) is greatly appreciated. NR 38 TC 11 Z9 11 U1 0 U2 11 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD APR PY 2010 VL 39 IS 4 BP 400 EP 409 DI 10.1007/s11664-010-1082-y PG 10 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 573HN UT WOS:000275900100007 ER PT J AU Philips, DA Bauch, TD AF Philips, David A. Bauch, Terry D. TI RAPID CORRECTION OF HYPOKALEMIA IN A PATIENT WITH AN IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR AND RECURRENT VENTRICULAR TACHYCARDIA SO JOURNAL OF EMERGENCY MEDICINE LA English DT Article DE hypokalemia; implantable cardioverter-defibrillator (ICD); cardiomyopathy; potassium; ventricular tachycardia (VT) ID POTASSIUM-CHLORIDE INFUSIONS; ANTIARRHYTHMIC-DRUG-THERAPY; SOTALOL; ARRHYTHMIAS; AMIODARONE AB We present the case of a 74-year-old man with non-ischemic dilatated cardiomyopathy and an implantable cardioverter-defibrillator presenting with a serum potassium of 2.6 mmol/L, recurrent unstable ventricular tachycardia, and multiple defibrillations. Administration of a rapid bolus of 20 mEq KCL solution via central venous access, followed by an additional total of 80 mEq (orally and intravenously [i.v.]) over the next 2 h, resulted in immediate resolution of his recurrent unstable dysrhythmia without toxic side effects. Guidelines for rapid correction of hypokalemia quote a maximum safe administration of 20 mEq i.v./h. In addition to discussing the clinical relevance and physiologic interactions of the variables leading to this patient's presentation, we discuss the successful termination of his sustained recurrent ventricular dysrhythmia by rapid potassium repletion above currently recommended rates. The patient we present is representative of a growing population, given medical and technological advances over the years. Potassium boluses may be reasonable in such circumstances, particularly in patients with ICDs. (C) 2010 Elsevier Inc. C1 [Philips, David A.] Brooke Army Med Ctr, Dept Cardiol, San Antonio, TX 78209 USA. [Bauch, Terry D.] Univ Texas Hlth Sci Ctr San Antonio, Serv Cardiol, Dept Med, San Antonio, TX 78229 USA. RP Philips, DA (reprint author), Brooke Army Med Ctr, Dept Cardiol, San Antonio, TX 78209 USA. NR 26 TC 1 Z9 1 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0736-4679 J9 J EMERG MED JI J. Emerg. Med. PD APR PY 2010 VL 38 IS 3 BP 308 EP 316 DI 10.1016/j.jemermed.2007.06.019 PG 9 WC Emergency Medicine SC Emergency Medicine GA 581ZI UT WOS:000276564200006 PM 18375090 ER PT J AU Lux, S Gu, LF Kopec, G Bernas, R Miley, G AF Lux, Scott Gu, Lifeng Kopec, Grant Bernas, Robert Miley, George TI Water Management Issues for Direct Borohydride/Peroxide Fuel Cells SO JOURNAL OF FUEL CELL SCIENCE AND TECHNOLOGY LA English DT Article DE sodium borohydride; water management; hydrogen peroxide; fuel cell ID SODIUM METABORATE; BORIC-ACID; HYDROGEN; GENERATION; CATALYST; CURVES; OXIDE AB This study evaluated water management strategies to lengthen the run time of a batch fueled direct sodium borohydride/peroxide (NaBH(4)/H(2)O(2)) proton exchange membrane fuel cell. The term "batch fueled" refers specifically to a fuel tank containing a fixed volume of fuels for use in the run. The length of a run using a fixed fuel tank is strongly influenced by water dynamics. The water that reacts at the anode is produced at the cathode, and is transported through the membrane via drag and diffusion. Resulting concentration changes in the fuel of the NaBH(4)/H(2)O(2) fuel cell were modeled to evaluate the run lifetime. The run time is defined as the amount of time required for NaBH(4) or for NaBO(2) (the byproduct compound) to reach either solubility limit or until the fuel is depleted, whichever occurs first. As part of the evaluation, an "effective" H(2)O drag coefficient (net drag minus back diffusion) with Nafion (R) 112 was experimentally determined to be 1.14 and 4.36 at 25 degrees C and 60 degrees C, respectively. The concentrations of the NaBH(4) and NaBO(2) solutions were calculated as a function of initial concentration, and for the case where H(2)O was supplied to the anode compartment during operation. Several strategies to increase the run time by both passive and active water management were considered. It is found that the run time is increased from 10 W h to 57 W h, with a decrease in the initial NaBH(4) concentration from 30 wt % (typically employed in these cells) to 10 wt %. Adding 0.125 ml/min H(2)O to the bulk anode solution increases the run time of a 10 wt % NaBH(4) solution by a factor of 1.6. Adding 0.225 ml/min H(2)O to 30 wt % NaBH(4) bulk solution increases the run time by a factor of 4.4. While attractive for increasing run time, the practicality of water addition depends on its availability or requires incorporation of an added unit, designed to separate and recirculate water from the cathode solution. [DOI: 10.1115/1.3176218] C1 [Lux, Scott] USA, Erdc, CERL, Champaign, IL 61822 USA. [Gu, Lifeng; Kopec, Grant; Bernas, Robert; Miley, George] Univ Illinois, Dept Nucl Plasma & Radiol Engn, Urbana, IL 61801 USA. RP Lux, S (reprint author), USA, Erdc, CERL, Champaign, IL 61822 USA. FU NPL Associates, Inc. under DARPA [SB04-032, FA9453-05-C-0084]; Cooperative Research and Development Agreement with U. S. Army ERDC-CERL [CRADA-07-CERL-01] FX The authors thank NPL Associates, Inc. for sharing their original DBFC technology for this work. This work was supported through NPL Associates, Inc. under DARPA Contract Nos. SB04-032 and FA9453-05-C-0084 and a Cooperative Research and Development Agreement with U. S. Army ERDC-CERL under Grant No. CRADA-07-CERL-01. NR 14 TC 5 Z9 5 U1 0 U2 5 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 1550-624X J9 J FUEL CELL SCI TECH JI J. Fuel Cell Sci. Technol. PD APR PY 2010 VL 7 IS 2 AR 024501 DI 10.1115/1.3176218 PG 5 GA 549AN UT WOS:000274013200025 ER PT J AU Pisarcik, S Herbert, A Olinger, G AF Pisarcik, Sarah Herbert, Andrew Olinger, Gene TI Alphavirus particle filovirus vaccine activation of Dendritic cells SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract C1 [Pisarcik, Sarah; Herbert, Andrew; Olinger, Gene] US Army Med Res Inst Infect Dis, Frederick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 EI 1550-6606 J9 J IMMUNOL JI J. Immunol. PD APR 1 PY 2010 VL 184 SU 1 MA 52.7 PG 1 WC Immunology SC Immunology GA V44OM UT WOS:000209758301172 ER PT J AU Patel, GK Yee, CL Montemorano, A Maggio, K Vogel, IC AF Patel, G. K. Yee, C. L. Montemorano, A. Maggio, K. Vogel, I. C. TI The role of cancer stem cells in the initiation and propagation of human cutaneous squamous cell carcinoma in an in vivo model SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT Annual Meeting of the Society-for-Investigative-Dermatology CY MAY 05-08, 2010 CL Atlanta, GA SP Soc Investtigat Dermatol C1 [Patel, G. K.] Cardiff Univ, Dept Dermatol & Wound Healing, Cardiff, Wales. [Patel, G. K.; Yee, C. L.; Vogel, I. C.] Natl Canc Inst, Dermatol Branch, Bethesda, MD USA. [Montemorano, A.] Rockledge Skin Canc Clin, Bethesda, MD USA. [Maggio, K.] Walter Reed Army Med Ctr, Dermatol Serv, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2010 VL 130 SU 1 MA 167 BP S28 EP S28 PG 1 WC Dermatology SC Dermatology GA 580ND UT WOS:000276455100165 ER PT J AU Cobb, BL Crowe, SR James, JA Engler, RJ Kaufman, KM Harley, JB AF Cobb, Beth L. Crowe, Sherry R. James, Judith A. Engler, Renata J. Kaufman, Kenneth M. Harley, John B. TI ANTHRAX VACCINE ADSORBED VACCINATION ANTI-PROTECTIVE ANTIGEN ANTIBODY LEVELS ARE ASSOCIATED WITH SLC35F1, ST6GALNAC3 AND RGS6 SO JOURNAL OF INVESTIGATIVE MEDICINE LA English DT Meeting Abstract CT Annual Combined Meeting of the Central-Society-for-Clinical-Research/Midwestern Section of the American-Federation-for-Medical-Research CY APR 22-23, 2010 CL Chicago, IL SP Cent Soc Clin Res, Amer Federat Med Res, Midwestern Sect C1 [Cobb, Beth L.; Crowe, Sherry R.; James, Judith A.; Kaufman, Kenneth M.; Harley, John B.] Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA. [James, Judith A.; Kaufman, Kenneth M.; Harley, John B.] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA. [Engler, Renata J.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1081-5589 J9 J INVEST MED JI J. Invest. Med. PD APR PY 2010 VL 58 IS 4 MA 85 BP 669 EP 670 PG 2 WC Medicine, General & Internal; Medicine, Research & Experimental SC General & Internal Medicine; Research & Experimental Medicine GA 583ZL UT WOS:000276719600097 ER PT J AU Grujicic, M Pandurangan, B Coutris, N Cheeseman, BA Roy, WN Skaggs, RR AF Grujicic, M. Pandurangan, B. Coutris, N. Cheeseman, B. A. Roy, W. N. Skaggs, R. R. TI Derivation, Parameterization and Validation of a Sandy-Clay Material Model for Use in Landmine Detonation Computational Analyses SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE blast resistance; granular materials; material modeling ID SATURATION; STRESS AB A set of large-strain/high-deformation-rate/high-pressure material models for sand-based soils with different saturation levels and clay and gravel contents was recently proposed and validated in our study, and the same has been extended in this study to include clay-based soils of different saturation levels and sand contents. The model includes an equation of state which reveals the material response under hydrostatic pressure, a strength model which captures material elastic-plastic response under shear, and a failure model which defines the laws and conditions for the initiation and evolution of damage and ultimate failure of the material under negative pressure and/or shear. The model was first parameterized using various open-literature experimental results and property correlation analyses and, then, validated by comparing the computational results obtained in an ANSYS/Autodyn-based transient non-linear dynamics analysis of detonation of a landmine buried in sandy-clay with their experimental counterparts. C1 [Grujicic, M.; Pandurangan, B.; Coutris, N.] Clemson Univ, Dept Mech Engn, ICAR, Clemson, SC 29634 USA. [Cheeseman, B. A.; Roy, W. N.; Skaggs, R. R.] USA, Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, ICAR, Clemson, SC 29634 USA. EM mica.grujicic@ces.clemson.edu FU U. S. Army/Clemson University Cooperative Agreements [W911NF-04-2-0024, W911NF-06-2-0042]; U. S. Army [DAAD19-01-1-0661]; ARC-TARDEC FX This study is based on the support provided by the U. S. Army/Clemson University Cooperative Agreements, W911NF-04-2-0024 and W911NF-06-2-0042, and by the U. S. Army Grant Number DAAD19-01-1-0661, and through an ARC-TARDEC research contract. NR 40 TC 6 Z9 6 U1 1 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD APR PY 2010 VL 19 IS 3 BP 434 EP 450 DI 10.1007/s11665-009-9509-4 PG 17 WC Materials Science, Multidisciplinary SC Materials Science GA 568RU UT WOS:000275541100017 ER PT J AU James, CD McClain, J Pohl, KR Reuel, N Achyuthan, KE Bourdon, CJ Rahimian, K Galambos, PC Ludwig, G Derzon, MS AF James, Conrad D. McClain, Jaime Pohl, Kenneth R. Reuel, Nigel Achyuthan, Komandoor E. Bourdon, Christopher J. Rahimian, Kamyar Galambos, Paul C. Ludwig, George Derzon, Mark S. TI High-efficiency magnetic particle focusing using dielectrophoresis and magnetophoresis in a microfluidic device SO JOURNAL OF MICROMECHANICS AND MICROENGINEERING LA English DT Article ID PATHOGEN DETECTION; ON-CHIP; SEPARATION; INSTRUMENTS; SIMULANTS; CHANNELS; AGENTS; ELISA; FOOD AB We describe a novel technique that utilizes simultaneous implementation of dielectrophoresis (DEP) and magnetophoresis (MAP) to focus magnetic particles into streams for optical analysis of biological samples. This technique does not require sheath flow and utilizes a novel interdigitated electrode array chip that yields multiple streams of flowing magnetic particles in single-file columns. The MAP force placed particles in close proximity to the microelectrodes where they were subjected to a strong DEP force that generated the particle focusing effect. Particle focusing efficiency was improved using this combination DEP-MAP technique compared to DEP alone: particle stream widths were reduced similar to 47% and stream width variability was reduced 80% for focused streams of 8.5 mu m diameter magnetic particles. 3 mu m diameter magnetic particles were strongly focused with DEP-MAP (similar to 4 mu m wide streams with sub-mu m variability in stream width) while DEP alone provided minimal focusing. Additional components of a prototype detection system were also demonstrated including an integrated magnetic pelleting component, a hand-held MHz frequency signal generator and a bench-top near-confocal microscope for optical analysis of flowing particles. Preliminary testing of a sandwich assay performed on the surface of magnetic particles showed 50 ppb detection levels of a surrogate biotoxin (ovalbumin) in a raw milk sample. C1 [James, Conrad D.; McClain, Jaime; Pohl, Kenneth R.; Achyuthan, Komandoor E.; Bourdon, Christopher J.; Rahimian, Kamyar; Galambos, Paul C.; Derzon, Mark S.] Sandia Natl Labs, Albuquerque, NM 87185 USA. [Reuel, Nigel] MIT, Cambridge, MA 02139 USA. [Ludwig, George] USA, Med Res & Mat Command, Frederick, MD 21702 USA. RP James, CD (reprint author), Sandia Natl Labs, Albuquerque, NM 87185 USA. EM cdjame@sandia.gov FU United States Department of Energy [DE-AC04-94AL85000] FX The authors thank Vickie Peck, Matthew Hopkins, James Cullor and Paul Rossitto for useful discussions, and Darin Graf, Cody Washburn, Patty Sawyer and John Anderson for device fabrication and experimental support. This work was funded by Sandia's Laboratory Directed Research and Development program. Sandia National Laboratories is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy under contract DE-AC04-94AL85000. NR 32 TC 16 Z9 16 U1 2 U2 14 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0960-1317 J9 J MICROMECH MICROENG JI J. Micromech. Microeng. PD APR PY 2010 VL 20 IS 4 AR 045015 DI 10.1088/0960-1317/20/4/045015 PG 9 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA 572OG UT WOS:000275841800016 ER PT J AU Rafuse, ES AF Rafuse, Ethan S. TI West Pointers and the Civil War: The Old Army in War and Peace. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Rafuse, Ethan S.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Rafuse, ES (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2010 VL 74 IS 2 BP 597 EP 598 PG 2 WC History SC History GA 581KO UT WOS:000276521600036 ER PT J AU Short, CA AF Short, Courtney A. TI Japanese Assimilation Policies in Colonial Korea 1910-1945. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Short, Courtney A.] US Mil Acad, West Point, NY 10996 USA. RP Short, CA (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2010 VL 74 IS 2 BP 609 EP 610 PG 2 WC History SC History GA 581KO UT WOS:000276521600045 ER PT J AU Stentiford, BM AF Stentiford, Barry M. TI Guarding the Border: The Military Memoirs of Ward Schrantz, 1912-1917. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Stentiford, Barry M.] Sch Adv Mil Studies, Ft Leavenworth, KS USA. RP Stentiford, BM (reprint author), Sch Adv Mil Studies, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2010 VL 74 IS 2 BP 611 EP 612 PG 2 WC History SC History GA 581KO UT WOS:000276521600046 ER PT J AU Bielakowski, AM AF Bielakowski, Alexander M. TI Tank Men: The Human Story of Tanks at War. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Bielakowski, Alexander M.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Bielakowski, AM (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2010 VL 74 IS 2 BP 619 EP 620 PG 2 WC History SC History GA 581KO UT WOS:000276521600052 ER PT J AU House, JM AF House, Jonathan M. TI The Second World War on the Eastern Front. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [House, Jonathan M.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP House, JM (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 1 U2 1 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2010 VL 74 IS 2 BP 633 EP 634 PG 2 WC History SC History GA 581KO UT WOS:000276521600061 ER PT J AU Betros, L AF Betros, Lance TI American Civil-Military Relations: The Soldier and the State in a New Era SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Betros, Lance] US Mil Acad, West Point, NY 10996 USA. RP Betros, L (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2010 VL 74 IS 2 BP 657 EP 659 PG 3 WC History SC History GA 581KO UT WOS:000276521600078 ER PT J AU Crowell, HP Milner, CE Hamill, J Davis, IS AF Crowell, Harrison Philip Milner, Clare E. Hamill, Joseph Davis, Irene S. TI Reducing Impact Loading During Running With the Use of Real-Time Visual Feedback SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE accelerometer; gait retraining; ground reaction forces; stress fracture; tibia ID GROUND REACTION FORCES; STRESS-FRACTURES; LOWER-EXTREMITY; ORTHOTIC DEVICE; SHOCK; INSTRUCTION; JUMP; BIOFEEDBACK; PREVENTION; INJURIES AB STUDY DESIGN: Single-subject with repeated measures. OBJECTIVES: To determine if runners can use real-time visual feedback from an accelerometer to achieve immediate reductions in tibial acceleration and vertical-force loading rates. BACKGROUND: Stress fractures are a common injury among runners. Previous studies suggest that runners with higher than normal tibial acceleration and vertical-force loading rates are at increased risk for tibial stress fractures. If these runners can be trained to reduce the loading on their lower extremities, it may reduce their risk of stress fractures. METHODS: five subjects participated in this study. All subjects ran on a treadmill, instrumented with force transducers, during a single 30-minute session that was divided into warm-up, feedback, no-feedback, and cool-down periods. During running, the subjects also wore an accelerometer taped to their distal right tibia. Peak positive acceleration of the tibia, vertical force impact peak, and average and instantaneous vertical-force loading rates were assessed at the end of the warm-up, feedback, and no-feedback periods. RESULTS: Single-subject analysis revealed that 4 of the 5 subjects had significant reductions in their peak positive acceleration at the end of the no-feedback period compared to the warm-up. In addition, all of the subjects had significant decreases in impact peak and vertical ground reaction force loading rates at the end of the no feedback period. CONCLUSION: In a single session of training with real-time visual feedback, it appears that most runners can reduce the types of lower extremity loading associated with stress fractures. This may lead to training programs that reduce the risk of stress fractures for runners, LEVEL OF EVIDENCE: Prevention, level 5. J Orthop Sports Phys Ther 2010;40(4):206-213. doi:10.2519/jospt.2010.3166 C1 [Crowell, Harrison Philip] USA, Res Lab, RDRL HRS B, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. [Milner, Clare E.] Univ Tennessee, Dept Exercise Sport & Leisure Studies, Knoxville, TN USA. [Hamill, Joseph] Univ Massachusetts, Dept Kinesiol, Amherst, MA 01003 USA. [Davis, Irene S.] Univ Delaware, Dept Phys Therapy, Newark, DE USA. [Davis, Irene S.] Drayer Phys Therapy Inst, Hummelstown, PA USA. RP Crowell, HP (reprint author), USA, Res Lab, RDRL HRS B, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. EM harrison.philip.crowell@us.army.mil OI Milner, Clare/0000-0002-8267-605X FU Department of Defense [DAMD17-00-1-0515] FX This work was supported by Department of Defense grant DAMD17-00-1-0515. NR 43 TC 50 Z9 51 U1 0 U2 31 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD APR PY 2010 VL 40 IS 4 BP 206 EP 213 DI 10.2519/jospt.2010.3166 PG 8 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 578UV UT WOS:000276322500003 PM 20357417 ER PT J AU Hsu, JR Stinner, DJ Brown, DA AF Hsu, Joseph R. Stinner, Daniel J. Brown, David A. CA Skeletal Trauma Res Consortium STR TI Splitting of the Proximal Femur With a New Femoral Nail SO JOURNAL OF ORTHOPAEDIC TRAUMA LA English DT Article DE lateral entry; trochanteric nail; intramedullary nailing; femur; complication ID ENTRY POINT; GAMMA-NAIL; SHAFT FRACTURES; INSERTION; TROCHANTER; INJURY AB We present a case of a 19-year-old woman with a closed diaphyseal femur fracture and who had fixation of the fracture using a newer lateral entry nail, which resulted in an intraoperative proximal femur fracture. The patient underwent revision the following day and subsequently returned to regular activity without signs of implant failure or loss of reduction at latest follow-up. Caution should be exercised with the use of new implants that require a change in customary technique. In addition, some concern must be raised by the amount of offset from the top of this particular nail to its long axis. C1 [Hsu, Joseph R.; Stinner, Daniel J.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Brown, David A.] Brooke Army Med Ctr, Orthoped Serv, Ft Sam Houston, TX 78234 USA. EM daniel.stinner@amedd.army.mil OI Stinner, Daniel/0000-0002-8981-6262 NR 18 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0890-5339 J9 J ORTHOP TRAUMA JI J. Orthop. Trauma PD APR PY 2010 VL 24 IS 4 BP E40 EP E43 DI 10.1097/BOT.0b013e3181a53790 PG 4 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 578XB UT WOS:000276329000015 PM 20335750 ER PT J AU Oetgen, ME Walick, KS Tulchin, K Karol, LA Johnston, CE AF Oetgen, Matthew E. Walick, Kristina S. Tulchin, Kirsten Karol, Lori A. Johnston, Charles E. TI Functional Results After Surgical Treatment for Congenital Knee Dislocation SO JOURNAL OF PEDIATRIC ORTHOPAEDICS LA English DT Article DE functional outcome; congenital deformity; knee dislocation AB Background: Congenital knee dislocation (CDK) is a rare congenital deformity, which often requires surgery for treatment. Little objective data exist characterizing the outcome of patients who require operative treatment for this condition. The purposes of this study were to objectively evaluate the functional, clinical, and gait outcomes of patients who underwent surgical treatment of CDK; and compare the results of outcome between 2 surgical approaches for this condition: quadricepsplasty and femoral shortening. Methods: We performed a retrospective review of all patients (7) treated surgically for CDK. Patients were evaluated at an average follow-up of 12+6 years. Each patient underwent a clinical examination, functional evaluation using the Lysholm Knee Questionnaire and Pediatric Outcomes Data Collection Instrument, and a 3-dimensional gait evaluation. The results of the total group were compared with normal controls. Additionally, results of the patients treated with quadricepsplasty were compared with patients treated with femoral shortening. Results: Total knee range of motion for the entire group averaged 112 degrees, with 8 of the 9 knees having flexion>90 degrees. Seven of the 9 knees were found to have some degree of instability on examination, yet none of the patients reported using any form of brace for ambulation. Functional evaluation showed good knee specific and overall function, comparable to normal controls. There were no differences in clinical or functional outcomes between the 2 surgical approaches. Gait analysis revealed a stiff-knee gait pattern to the congenital knee dislocation group, as compared with normal controls, and subtle differences in knee function between the surgical approaches. Conclusions: The function of patients after surgical treatment for CDK seems to be quite good compared with normal controls. Good knee specific and overall function scores are reported with limitations seen only in higher demand activities. Despite instability of the knee noticed on clinical examination, patients ambulate without braces and have a functional knee range of motion. Little difference in outcome was seen between the 2 surgical approaches used to treat this condition. C1 [Oetgen, Matthew E.; Tulchin, Kirsten; Karol, Lori A.; Johnston, Charles E.] Texas Scottish Rite Hosp Children, Dallas, TX 75219 USA. [Walick, Kristina S.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. RP Johnston, CE (reprint author), Texas Scottish Rite Hosp Children, 2222 Welborn St, Dallas, TX 75219 USA. EM Charles.Johnston@tsrh.org NR 20 TC 9 Z9 9 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0271-6798 J9 J PEDIATR ORTHOPED JI J. Pediatr. Orthop. PD APR-MAY PY 2010 VL 30 IS 3 BP 216 EP 223 DI 10.1097/BPO.0b013e3181d48375 PG 8 WC Orthopedics; Pediatrics SC Orthopedics; Pediatrics GA 573XU UT WOS:000275950600002 PM 20357585 ER PT J AU Sanan, TT Muthukrishnan, S Beck, JM Tao, P Hayes, CJ Otto, TC Cerasoli, DM Lenz, DE Hadad, CM AF Sanan, Toby T. Muthukrishnan, Sivaramakrishnan Beck, Jeremy M. Tao, Peng Hayes, Carrigan J. Otto, Tamara C. Cerasoli, Douglas M. Lenz, David E. Hadad, Christopher M. TI Computational modeling of human paraoxonase 1: preparation of protein models, binding studies, and mechanistic insights SO JOURNAL OF PHYSICAL ORGANIC CHEMISTRY LA English DT Article; Proceedings Paper CT International Symposium on Reactive Intermediates and Unusual Molecules CY JUL 05-10, 2009 CL Liblice, CZECH REPUBLIC DE bioscavenger; catalytic hydrolysis; organophosphorus compounds; paraoxonase ID DENSITY-FUNCTIONAL THERMOCHEMISTRY; HUMAN SERUM PARAOXONASE; DIISOPROPYL FLUOROPHOSPHATASE; MOLECULAR-DYNAMICS; POTENTIAL FUNCTIONS; LACTONASE ACTIVITY; LIQUID WATER; FORCE-FIELD; HYDROLYSIS; EXCHANGE AB The enzyme human paraoxonase 1 (huPON1) has demonstrated significant potential for use as a bioscavenger for treatment of exposure to organophosphorus (OP) nerve agents. Herein we report the development of protein models for the human isoform derived from a crystal structure of a chimeric version of the protein (pdb ID: 1V04) and a homology model derived from the related enzyme diisopropylfluorophosphatase (pdb ID: 1XHR). From these structural models, binding modes for OP substrates are predicted, and these poses are found to orient substrates in proximity to residues known to modulate specificity of the enzyme. Predictions are made with regard to the role that residues play in altering substrate binding and turnover, in particular with regard to the stereoselectivity of the enzyme, and the known differences in activity related to a natural polymorphism in the enzyme. Potential mechanisms of action of the protein for catalytic hydrolysis of OP substrates are also evaluated in light of the proposed binding modes. Copyright (C) 2010 John Wiley & Sons, Ltd. C1 [Sanan, Toby T.; Muthukrishnan, Sivaramakrishnan; Beck, Jeremy M.; Tao, Peng; Hayes, Carrigan J.; Hadad, Christopher M.] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA. [Otto, Tamara C.; Cerasoli, Douglas M.; Lenz, David E.] USA, Med Res Inst Chem Def, Physiol & Immunol Branch, Div Res, Aberdeen Proving Ground, MD 21010 USA. RP Hadad, CM (reprint author), Ohio State Univ, Dept Chem, 100 W 18th Ave, Columbus, OH 43210 USA. EM hadad.1@osu.edu RI Tao, Peng/H-4925-2014; OI Tao, Peng/0000-0002-2488-0239; Hadad, Christopher/0000-0003-1211-4315 FU National Institutes of Health [U54-N5058183] FX We gratefully acknowledge financial support of this research by the National Institutes of Health (U54-N5058183). Generous computational resources have been provided by the Ohio Supercomputer Center. We also acknowledge fruitful and insightful discussions with Professor Thomas Magliery (OSU). The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the United States Army or the Department of Defense. NR 57 TC 12 Z9 12 U1 1 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0894-3230 EI 1099-1395 J9 J PHYS ORG CHEM JI J. Phys. Org. Chem. PD APR PY 2010 VL 23 IS 4 SI SI BP 357 EP 369 DI 10.1002/poc.1678 PG 13 WC Chemistry, Organic; Chemistry, Physical SC Chemistry GA 584UG UT WOS:000276778100012 PM 24077808 ER PT J AU Utz, ER Elster, EA Tadaki, DK Gage, F Perdue, PW Forsberg, JA Stojadinovic, A Hawksworth, JS Brown, TS AF Utz, Edward R. Elster, Eric A. Tadaki, Douglas K. Gage, Frederick Perdue, Philip W. Forsberg, Jonathan A. Stojadinovic, Alexander Hawksworth, Jason S. Brown, Trevor S. TI Metalloproteinase Expression is Associated with Traumatic Wound Failure SO JOURNAL OF SURGICAL RESEARCH LA English DT Article DE Luminex; MMP-2; MMP-3; MMP-7; effluent; multiplex; dehiscence; acute wound; VAC ID OPERATION IRAQI FREEDOM; GINGIVAL CREVICULAR FLUID; MATRIX METALLOPROTEINASES; EXTREMITY WOUNDS; ENDURING FREEDOM; THERAPY; BLAST; MECHANISMS; INJURIES; BIOLOGY AB Background. Matrix metalloproteinases (MMPs) are crucial in the inflammatory and remodeling phases of wound healing. We previously reported the correlation between pro-inflammatory cytokines and timing of successful combat-wound closure. We now extend our studies to investigate the correlation between wound-remodeling MMP expression and wound healing. Methods. Thirty-eight wounds in 25 patients with traumatic extremity combat wounds were prospectively studied. Surgical debridement with vacuum-assisted closure (VAC) device application was repeated every 48 to 72h until surgical wound closure. Wound effluent and patient serum were collected at each wound debridement and analyzed for five matrix metalloproteinases using the Luminex multiplex system; Millipore Corp, Billerica, MA. The primary outcome was wound healing within 30 d of definitive wound closure. Impairment was defined as delayed wound closure (>21 d from injury) or wound dehiscence. MMP expression was compared between impaired and normal healing wounds. Results. Elevated levels of serum MMP-2 and MMP-7 and reduced levels of effluent MMP3 were seen in impaired wounds (n = 9) compared with wounds that healed (n = 29; P<0.001). Receiver operating characteristic (ROC) curve analysis yielded area-under-the-curve (AUC) of 0.744, 0.783, and 0.805, respectively. Conclusions. Impaired wound healing is characterized by pro-inflammatory MMP-2 and MMP-7. Serum and effluent concentrations of MMP-2, MMP-3, and MMP-7 can effectively predict the outcome of traumatic war wounds and can potentially provide decision-supportive, objective evidence for the timing of wound closure. Published by Elsevier Inc. C1 [Utz, Edward R.; Elster, Eric A.; Tadaki, Douglas K.; Gage, Frederick; Forsberg, Jonathan A.; Hawksworth, Jason S.; Brown, Trevor S.] USN, Med Res Ctr, Regenerat Med Dept, Silver Spring, MD 20910 USA. [Stojadinovic, Alexander; Hawksworth, Jason S.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Utz, Edward R.; Elster, Eric A.; Tadaki, Douglas K.; Forsberg, Jonathan A.; Stojadinovic, Alexander] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. [Elster, Eric A.; Perdue, Philip W.] Natl Naval Med Ctr, Dept Surg, Bethesda, MD USA. [Forsberg, Jonathan A.] Walter Reed Natl Mil Med Ctr, Integrated Dept Orthopaed & Rehabil, Bethesda, MD USA. RP Brown, TS (reprint author), USN, Med Res Ctr, Regenerat Med Dept, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Trevor.Brown@med.navy.mil RI Brown, Trevor/K-4703-2012; Brown, Trevor/F-7392-2015 OI Brown, Trevor/0000-0001-7042-785X; Brown, Trevor/0000-0001-7042-785X FU U.S. Navy Bureau of Medicine and Surgery [PE 0604771 N]; Alpha Omega Alpha Carolyn L. Kuckein Student Research Fellowship FX The multidisciplinary care of these patients would not have been possible without the dedicated efforts of everyone at NNMC. Both civilian and military personnel have rendered skilled and compassionate care for these casualties. All of our efforts are dedicated to those who have been placed in harm's way for the good of our nation. This effort was supported (in part) by the U.S. Navy Bureau of Medicine and Surgery under the Medical Development Program (PE 0604771 N) and in part by an Alpha Omega Alpha Carolyn L. Kuckein Student Research Fellowship. NR 27 TC 38 Z9 38 U1 0 U2 5 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 J9 J SURG RES JI J. Surg. Res. PD APR PY 2010 VL 159 IS 2 BP 633 EP 639 DI 10.1016/j.jss.2009.08.021 PG 7 WC Surgery SC Surgery GA 575MU UT WOS:000276072000005 PM 20056248 ER PT J AU Pinholt, E Castro, E Mitchell, J Butler, J AF Pinholt, E. Castro, E. Mitchell, J. Butler, J. TI When Providers Find a Loaded Gun: Advocating Gun Safety Competency for Home Visit Providers. SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Meeting of the American-Geriatrics-Society CY MAY 12-15, 2010 CL Orlando, FL SP Amer Geriatr Soc C1 [Pinholt, E.; Castro, E.; Mitchell, J.; Butler, J.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0002-8614 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2010 VL 58 SU 1 BP 79 EP 80 PG 2 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA 577TO UT WOS:000276247100228 ER PT J AU Zivan, L Tischler, MB AF Zivan, Lior Tischler, Mark B. TI Development of a Full Flight Envelope Helicopter Simulation Using System Identification SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article; Proceedings Paper CT 63rd Annual Forum of the American-Helicopter-Society CY MAY 01-03, 2007 CL Virginia Beach, VA SP Amer Helicopter Soc AB Frequency-domain system identification techniques were used to develop a series of mathematical models of the Bell 206 helicopter, each valid at different flight conditions. The models were combined and "stitched" together to produce a continuous full flight envelope model of the helicopter. The model was implemented in a simple simulator and evaluated by several pilots, all flight qualified in this helicopter. It was the opinion of the pilots that the simulation is a good representation of the aircraft for all tasks of interest. C1 [Zivan, Lior] Ben Gurion Int Airport, Israel Aerosp Ind, Div Engn, Flight Control Syst Dept, Tel Aviv, Israel. [Tischler, Mark B.] USA, Res Dev & Engn Command, Ames Res Ctr, Moffett Field, CA USA. RP Zivan, L (reprint author), Ben Gurion Int Airport, Israel Aerosp Ind, Div Engn, Flight Control Syst Dept, Tel Aviv, Israel. EM lzivan@iai.co.il NR 13 TC 3 Z9 3 U1 0 U2 5 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD APR PY 2010 VL 55 IS 2 AR 022003 DI 10.4050/JAHS.55.022003 PG 15 WC Engineering, Aerospace SC Engineering GA 745OV UT WOS:000289175900003 ER PT J AU Gould, M Adler, A Zamorski, M Castro, C Hanily, N Steele, N Kearney, S Greenberg, N AF Gould, Matthew Adler, Amy Zamorski, Mark Castro, Carl Hanily, Natalie Steele, Nicole Kearney, Steve Greenberg, Neil TI Do stigma and other perceived barriers to mental health care differ across Armed Forces? SO JOURNAL OF THE ROYAL SOCIETY OF MEDICINE LA English DT Article ID MILITARY PERSONNEL; PSYCHOLOGICAL ILLNESS; SERVICE PERSONNEL; IRAQ WAR; COMBAT; POPULATION; DISORDERS; SAMPLE AB Objectives Military organizations are keen to address barriers to mental health care yet stigma and barriers to care remain little understood, especially potential cultural differences between Armed Forces. The aim of this study was to compare data collected by the US, UK, Australian, New Zealand and Canadian militaries using Hoge et al.'s perceived stigma and barriers to care measure (Combat duty in Iraq and Afghanistan, mental health problems and barriers to care. New Engl J Med 2004;351:13-22). Design Each member country identified data sources that had enquired about Hoge et al.'s perceived stigma and perceived barriers to care items in the re-deployment or immediate post-deployment period. Five relevant statements were included in the study. Setting US, UK Australian, New Zealand and Canadian Armed Forces. Results Concerns about stigma and barriers to care tended to be more prominent among personnel who met criteria for a mental health problem. The pattern of reported stigma and barriers to care was similar across the Armed Forces of all five nations. Conclusions Barriers to care continue to be a major issue for service personnel within Western military forces. Although there are policy, procedural and cultural differences between Armed Forces, the nations studied appear to share some similarities in terms of perceived stigma and barriers to psychological care. Further research to understand patterns of reporting and subgroup differences is required. C1 [Greenberg, Neil] Kings Coll London, Acad Ctr Def Mental Hlth, Weston Educ Ctr, London SE5 9RJ, England. [Gould, Matthew] DCMH, UK Minist Def, Def Clin Psychol Serv, Portsmouth PO1 3LT, Hants, England. [Adler, Amy] US Army Med Res Unit Europe, D-69126 Heidelberg, Germany. [Zamorski, Mark] Canadian Forces Hlth Serv Grp, Ottawa, ON K1A 0KG, Canada. [Castro, Carl] Walter Reed Army Inst Res, Dept Mil Psychiat, Silver Spring, MD 20910 USA. [Hanily, Natalie] Psychol Support Sect S Queensland, Enoggera, Qld 4035, Australia. [Steele, Nicole] Joint Hlth Command CP 2 7 098, Canberra, ACT 2600, Australia. [Kearney, Steve] HQ Joint Forces, Wellington, New Zealand. RP Greenberg, N (reprint author), Kings Coll London, Acad Ctr Def Mental Hlth, Weston Educ Ctr, Cutcombe Rd, London SE5 9RJ, England. EM sososanta@aol.com NR 26 TC 49 Z9 49 U1 2 U2 13 PU ROYAL SOC MEDICINE PRESS LTD PI LONDON PA 1 WIMPOLE STREET, LONDON W1G 0AE, ENGLAND SN 0141-0768 J9 J ROY SOC MED JI J. R. Soc. Med. PD APR PY 2010 VL 103 IS 4 BP 148 EP 156 DI 10.1258/jrsm.2010.090426 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA 619NL UT WOS:000279436800011 PM 20382906 ER PT J AU Yokota, M Berglund, LG Bathalon, GP AF Yokota, Miyo Berglund, Larry G. Bathalon, Gaston P. TI Monte Carlo simulations of individual variability and their effects on simulated heat stress using thermoregulatory modeling SO JOURNAL OF THERMAL BIOLOGY LA English DT Article DE Anthropometry; Monte Carlo; Thermal regulatory model; Heat stress; Core temperature ID RESPONSES; WORK AB This paper addresses a variable-dependence (VD) MC method developed based on a previous attempt (VI-MC method) (J. Therm. Biol. 29 (2004), 515) to be incorporated in a thermoregulatory model. Simulated individuals with anthropometrics by VI- and VD-MC methods for US Army population were compared using principal component analysis and Fisher's exact tests. The results indicated that VD-MC data represented overall body size as the primary component and body shape as the secondary component that were more realistic and similar to the measured US Army data (p > 0.05) rather than VI-MC data (p < 0.05). Such differences consequently affected individual thermoregulatory responses to simulated heat stress. The VD-MC method provides a more realistic representation of individual variability and thus underpins more realistic predictions of individual thermoregulatory responses. Published by Elsevier Ltd. C1 [Yokota, Miyo; Berglund, Larry G.; Bathalon, Gaston P.] USA, Environm Med Res Inst, Biophys & Biomed Modeling Div, Natick, MA 01760 USA. RP Yokota, M (reprint author), USA, Environm Med Res Inst, Biophys & Biomed Modeling Div, Natick, MA 01760 USA. EM Miyo.Yokota@us.army.mil NR 20 TC 3 Z9 3 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0306-4565 J9 J THERM BIOL JI J. Therm. Biol. PD APR PY 2010 VL 35 IS 3 BP 154 EP 159 DI 10.1016/j.jtherbio.2010.02.002 PG 6 WC Biology; Zoology SC Life Sciences & Biomedicine - Other Topics; Zoology GA 579MF UT WOS:000276374100008 ER PT J AU Milner, EE AF Milner, Erin Elizabeth TI The Grandfather of Organic Chemistry: Robert Burns Woodward, PhD SO LABMEDICINE LA English DT Biographical-Item C1 Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Milner, EE (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. NR 1 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC CLINICAL PATHOLOGY PI CHICAGO PA 2100 W HARRISON ST, CHICAGO, IL 60612 USA SN 0007-5027 J9 LABMEDICINE JI Labmedicine PD APR PY 2010 VL 41 IS 4 BP 245 EP 246 DI 10.1309/LM7LBJZCC20JLKSD PG 2 WC Medical Laboratory Technology SC Medical Laboratory Technology GA 575BN UT WOS:000276039000010 ER PT J AU St-Louis, V Pidgeon, AM Clayton, MK Locke, BA Bash, D Radeloff, VC AF St-Louis, Veronique Pidgeon, Anna M. Clayton, Murray K. Locke, Brian A. Bash, Dallas Radeloff, Volker C. TI Habitat variables explain Loggerhead Shrike occurrence in the northern Chihuahuan Desert, but are poor correlates of fitness measures SO LANDSCAPE ECOLOGY LA English DT Article DE Loggerhead Shrike; Chihuahuan Desert; Habitat use; Habitat quality; Fitness; Multi-scale habitat associations; Image texture ID SPARROW AMPHISPIZA-BILINEATA; SATELLITE IMAGE TEXTURE; NESTING SUCCESS; REPRODUCTIVE SUCCESS; VEGETATION STRUCTURE; BREEDING SUCCESS; GRASSLAND BIRDS; DENSITY; MODELS; CONSERVATION AB Conservation efforts should be based on habitat models that identify areas of high quality and that are built at spatial scales that are ecologically relevant. In this study, we developed habitat models for the Loggerhead Shrike (Lanius ludovicianus) in the Chihuahuan Desert of New Mexico to answer two questions: (1) are highly used habitats of high quality for shrikes in terms of individual fitness? and (2) what are the spatial scales of habitat associations relevant to this species? Our study area was Fort Bliss Army Reserve (New Mexico). Bird abundance was obtained from 10 min point counts conducted at forty-two 108 ha plots during a 3-year period. Measures of fitness were obtained by tracking a total of 73 nests over the 3 years. Habitat variables were measured at spatial scales ranging from broad to intermediate to local. We related habitat use and measures of fitness to habitat variables using Bayesian model averaging. We found a significant relationship between bird abundance and measures of fitness averaged across nesting birds in each plot (correlation up to 0.61). This suggests that measures of habitat use are indicative of habitat quality in the vicinity of Fort Bliss. Local- and intermediate-scale variables best explained shrike occurrence. Habitat variables were not related to any measures of fitness. A better understanding of the factors that limit individual bird fitness is therefore necessary to identify areas of high conservation value for this species. C1 [St-Louis, Veronique; Pidgeon, Anna M.; Radeloff, Volker C.] Univ Wisconsin, Dept Forest & Wildlife Ecol, Madison, WI 53706 USA. [Clayton, Murray K.] Univ Wisconsin, Dept Stat, Madison, WI 53706 USA. [Locke, Brian A.; Bash, Dallas] IMWE PWD E, Div Environm, DPW, Ft Bliss, TX 79916 USA. RP St-Louis, V (reprint author), Brown Univ, Environm Change Initiat, Box 1951, Providence, RI 02912 USA. EM veroniquestlouis@gmail.com RI Radeloff, Volker/B-6124-2016 OI Radeloff, Volker/0000-0001-9004-221X NR 56 TC 6 Z9 6 U1 2 U2 24 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0921-2973 J9 LANDSCAPE ECOL JI Landsc. Ecol. PD APR PY 2010 VL 25 IS 4 BP 643 EP 654 DI 10.1007/s10980-010-9451-8 PG 12 WC Ecology; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA 567JY UT WOS:000275444100012 ER PT J AU Steere, PJ AF Steere, Paul J. TI CONGRESS CREATES SUPER FEDERAL LIBRARY AGENCY SO LIBRARY JOURNAL LA English DT Article C1 [Steere, Paul J.] USA, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD APR 1 PY 2010 VL 135 IS 6 BP 18 EP 21 PG 4 WC Information Science & Library Science SC Information Science & Library Science GA 576KE UT WOS:000276142400006 ER PT J AU Burgess, E AF Burgess, Edwin TI The Ice Road: An Epic Journey from the Stalinist Labor Camps to Freedom SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, E (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD APR 1 PY 2010 VL 135 IS 6 BP 85 EP 85 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 576KE UT WOS:000276142400134 ER PT J AU Burgess, E AF Burgess, Edwin TI Winston's War: Churchill, 1940-1945 SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, E (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD APR 1 PY 2010 VL 135 IS 6 BP 85 EP 86 PG 2 WC Information Science & Library Science SC Information Science & Library Science GA 576KE UT WOS:000276142400135 ER PT J AU Burgess, E AF Burgess, Edwin TI On the Front Lines of the Cold War: An American Correspondent's Journal from the Chinese Civil War to the Cuban Missile Crisis and Vietnam SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, E (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD APR 1 PY 2010 VL 135 IS 6 BP 85 EP 85 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 576KE UT WOS:000276142400133 ER PT J AU Burgess, E AF Burgess, Edwin TI Every Man in This Village Is a Liar: An Education in War SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, E (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD APR 1 PY 2010 VL 135 IS 6 BP 85 EP 85 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 576KE UT WOS:000276142400132 ER PT J AU Burgess, E AF Burgess, Edwin TI Fighter Pilot: The Memoirs of Legendary Ace Robin Olds SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, E (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 1 U2 1 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD APR 1 PY 2010 VL 135 IS 6 BP 85 EP 85 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 576KE UT WOS:000276142400131 ER PT J AU Burgess, E AF Burgess, Edwin TI Kaboom: Embracing the Suck in a Savage Little War SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, E (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD APR 1 PY 2010 VL 135 IS 6 BP 85 EP 85 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 576KE UT WOS:000276142400130 ER PT J AU Burgess, E AF Burgess, Edwin TI The World's Bloodiest History: Massacre, Genocide, and the Scars Left on Civilization SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, E (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD APR 1 PY 2010 VL 135 IS 6 BP 86 EP 86 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 576KE UT WOS:000276142400138 ER PT J AU Burgess, E AF Burgess, Edwin TI Hero of the Air: Glenn Curtiss and the Birth of Naval Aviation SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, E (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD APR 1 PY 2010 VL 135 IS 6 BP 86 EP 86 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 576KE UT WOS:000276142400142 ER PT J AU Burgess, E AF Burgess, Edwin TI Eyes in the Sky: Eisenhower, the CIA, and the Cold War SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, E (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD APR 1 PY 2010 VL 135 IS 6 BP 86 EP 86 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 576KE UT WOS:000276142400141 ER PT J AU Burgess, E AF Burgess, Edwin TI The Dream Machine: The Untold History of the Notorious V-22 Osprey SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, E (reprint author), US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 2 U2 3 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD APR 1 PY 2010 VL 135 IS 6 BP 86 EP 86 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 576KE UT WOS:000276142400143 ER PT J AU Burgess, E AF Burgess, Edwin TI Islands of Hell: The US Marines in the Western Pacific, 1944-1945 SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, E (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD APR 1 PY 2010 VL 135 IS 6 BP 86 EP 86 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 576KE UT WOS:000276142400140 ER PT J AU Burgess, E AF Burgess, Edwin TI The Long Way Home: An American Journey from Ellis Island to the Great War SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, E (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD APR 1 PY 2010 VL 135 IS 6 BP 86 EP 86 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 576KE UT WOS:000276142400139 ER PT J AU Burgess, E AF Burgess, Edwin TI SEAL of Honor: Operation Red Wings and the Life of Lt. SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, E (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD APR 1 PY 2010 VL 135 IS 6 BP 86 EP 86 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 576KE UT WOS:000276142400136 ER PT J AU Burgess, E AF Burgess, Edwin TI The Immortals: History's Fighting Elites SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, E (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD APR 1 PY 2010 VL 135 IS 6 BP 86 EP 86 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 576KE UT WOS:000276142400137 ER PT J AU Burgess, E AF Burgess, Edwin TI The Untold War: Inside the Hearts, Minds, and Souls of Our Soldiers SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, E (reprint author), US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD APR 1 PY 2010 VL 135 IS 6 BP 87 EP 87 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 576KE UT WOS:000276142400148 ER PT J AU Burgess, E AF Burgess, Edwin TI Dangerous Ground: America's Failed Arms Control Policy, from FDR to Obama SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, E (reprint author), US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD APR 1 PY 2010 VL 135 IS 6 BP 87 EP 87 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 576KE UT WOS:000276142400146 ER PT J AU Burgess, E AF Burgess, Edwin TI Waging War in Waziristan: The British Struggle in the Land of Bin Laden, 1849-1947 SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, E (reprint author), US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD APR 1 PY 2010 VL 135 IS 6 BP 87 EP 87 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 576KE UT WOS:000276142400147 ER PT J AU Burgess, E AF Burgess, Edwin TI War by Land, Sea and Air: Dwight Eisenhower and the Concept of Unified Command SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, E (reprint author), US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD APR 1 PY 2010 VL 135 IS 6 BP 87 EP 87 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 576KE UT WOS:000276142400145 ER PT J AU Burgess, E AF Burgess, Edwin TI Militant Islamist Ideology: The Threat to the West SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, E (reprint author), US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 1 U2 1 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD APR 1 PY 2010 VL 135 IS 6 BP 87 EP 87 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 576KE UT WOS:000276142400144 ER PT J AU Cloran, FJ Banks, KP Song, WS Kim, Y Bradley, YC AF Cloran, Francis J. Banks, Kevin P. Song, Won S. Kim, Young Bradley, Yong C. TI Limitations of dual time point PET in the assessment of lung nodules with low FDG avidity SO LUNG CANCER LA English DT Article DE Dual time point; Delayed imaging; Positron emission tomography; Lung cancer; Lung nodule; SUV ID POSITRON-EMISSION-TOMOGRAPHY; PULMONARY NODULES; F-18-FDG PET; DIAGNOSIS AB FDG PET has long shown efficacy in the evaluation of indeterminate pulmonary nodules. More recently, the use of dual time point imaging has been looked at as a means for improving sensitivity and accuracy. While initial reports were very promising, more recent results looking specifically at pulmonary lesions with low levels of FDG avidity demonstrated limitations. These lesions (initial maximum standard uptake value of less than 2.5) are of particular interest due to the fact that well-differentiated adenocarcinomas, broncheoaveolar carcinoma and carcinoid may have low FDG avidity on standard PET imaging, leading to false-negative exams. Our study retrospectively reviewed the accuracy of dual time point (DTP) FDG PET imaging to determine if it aided in the identification of malignant pulmonary nodules when initial time point imaging showed a maximum SUV of less than 2.5. 113 patients had undergone a total of 130 DTP PET/CT with 152 lesions assessed. 67 lesions were subsequently definitively diagnosed as benign or malignant based upon biopsy or imaging follow-up. Utilizing a maximum SUV increase of 10%, which optimizes our sensitivity and specificity; our results demonstrate a sensitivity of 63% and a specificity of 59%, similar to other investigators evaluating lesions with low FDG avidity Increasing or decreasing this threshold did not improve our results, nor did the addition of lesions with maximum SUV's of 2.5 or greater on initial imaging. Specifically in nodules with low FDG avidity (max SUV < 2.5), the sensitivity was 61%, specificity 58%, and accuracy was 60%. Our findings suggest that DTP FOG PET may not be of benefit in the assessment of pulmonary nodules with maximum SUV of less than 2.5 on initial imaging. Published by Elsevier Ireland Ltd. C1 [Cloran, Francis J.; Banks, Kevin P.; Song, Won S.; Kim, Young; Bradley, Yong C.] Brooke Army Med Ctr, Dept Radiol, Ft Sam Houston, TX 78234 USA. [Cloran, Francis J.; Kim, Young] Wilford Hall USAF Med Ctr, Dept Radiol, Lackland AFB, TX 78236 USA. RP Banks, KP (reprint author), Brooke Army Med Ctr, Dept Radiol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM kevin.banks@amedd.army.mil NR 9 TC 34 Z9 37 U1 0 U2 2 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0169-5002 J9 LUNG CANCER JI Lung Cancer PD APR PY 2010 VL 68 IS 1 BP 66 EP 71 DI 10.1016/j.lungcan.2009.05.013 PG 6 WC Oncology; Respiratory System SC Oncology; Respiratory System GA 579NN UT WOS:000276378400010 PM 19559496 ER PT J AU Kenefick, RW AF Kenefick, Robert W. TI Energy Cost of Physical Activities in Persons with Spinal Cord Injury-Comment SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Editorial Material ID MEN C1 USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Kenefick, RW (reprint author), USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 8 TC 1 Z9 1 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD APR PY 2010 VL 42 IS 4 BP 689 EP 690 DI 10.1249/MSS.0b013e3181bf631b PG 2 WC Sport Sciences SC Sport Sciences GA 571DC UT WOS:000275730500009 PM 21099758 ER PT J AU Chen, MK Chang, YC Yang, CE Guo, YH Mazurowski, J Yin, S Ruffin, P Brantley, C Edwards, E Luo, C AF Chen, Meng-Ku Chang, Yun-Ching Yang, Chia-En Guo, Yaohui Mazurowski, John Yin, Stuart Ruffin, Paul Brantley, Christina Edwards, Eugene Luo, Claire TI TUNABLE TERAHERTZ PLASMONIC LENSES BASED ON SEMICONDUCTOR MICROSLITS SO MICROWAVE AND OPTICAL TECHNOLOGY LETTERS LA English DT Article DE terahertz; plasmonics; semiconductor microslits ID TRANSMISSION; ARRAYS AB A theoretical investigation of tunable terahertz (THz) plasmonic lenses on the basis of InSb microslits is presented. First, it is demonstrated that the surface plasmon polaritons propagating in an InSb microslit array with variant slit widths would face different phase retardations. which. by design. can produce a focusing wavefront. The extraordinary transmission of THz radiation through the InSb subwavelength slit array is also observed. Second. a method for timing the focal lengths of InSb plasmonic lenses is proposed. The results in this article provide a potential way to realize a tunable terahertz plasmonic lens with high transmission, which can be applied to the application of rapid 3D z-scanning based THz imaging and sensing. (C) 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 979-981, 2010: Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25079 C1 [Chen, Meng-Ku; Chang, Yun-Ching; Yang, Chia-En; Guo, Yaohui; Yin, Stuart] Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. [Mazurowski, John] Penn State Univ, Ctr Electroopt, University Pk, PA 16802 USA. [Ruffin, Paul; Brantley, Christina; Edwards, Eugene] USA, Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA. [Luo, Claire] Gen Opto Solut LLC, State Coll, PA 16803 USA. RP Chen, MK (reprint author), Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. EM sxy105@psu.edu FU Office of Naval Research FX Partial financial support of this work by the Basic Research Program of the Office of Naval Research is greatly appreciated. NR 10 TC 18 Z9 18 U1 2 U2 9 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0895-2477 J9 MICROW OPT TECHN LET JI Microw. Opt. Technol. Lett. PD APR PY 2010 VL 52 IS 4 BP 979 EP 981 DI 10.1002/mop.25079 PG 3 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA 569YZ UT WOS:000275640100057 ER PT J AU Zacker, LL Thompson, JC Murray, CK AF Zacker, Lisa L. Thompson, Jennifer C. Murray, Clinton K. TI Re: Determination of the Internal Medicine Service's Role in Emergency Department Length of Stay at a Military Medical Center. Mil Med 2009; 174: 1163-6. Response SO MILITARY MEDICINE LA English DT Letter C1 [Zacker, Lisa L.; Thompson, Jennifer C.; Murray, Clinton K.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Zacker, LL (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2010 VL 175 IS 4 BP III EP IV PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 582GQ UT WOS:000276585100002 ER PT J AU Pickering, MA Hammermeister, J Ohson, C Holliday, B Ulmer, G AF Pickering, Michael A. Hammermeister, Jon Ohson, Carl Holliday, Bernie Ulmer, Graham TI An Exploratory Investigation of Relationships Among Mental Skills and Resilience in Warrior Transition Unit Cadre Members SO MILITARY MEDICINE LA English DT Article ID POSITIVE EMOTIONS; STRESS; INDIVIDUALS; EXPERIENCES; ADVERSITY; HEALTH; SCALE; BACK AB Warrior transition unit (WTU) cadre members are exposed to a variety of stressors that put them at risk for adverse conditions and events. Resilience may be a construct capable of moderating some of these potential negative outcomes. In turn, mental toughness is a concept associated with resilience that may provide a unique framework from which to train resilient behavior. This article explored associations between resilience and several mental skills that are assumed to be related to mental toughness, in a sample (n = 27) of WTU cadre members in the U.S. Army. Instruments included the Ottawa Mental Skills Inventory (OMSAT-3) and the Resilience Scale (RS). Both cognitive mental skills and emotion management skills were positively associated with resilience. Results also indicated a model specifying emotion management as a mediator of the relationship between cognitive skills and resilience was consistent with the study data. C1 [Pickering, Michael A.; Hammermeister, Jon; Ohson, Carl; Holliday, Bernie] W Point Mil Acad, Ctr Enhanced Performance, West Point, NY 10996 USA. [Ulmer, Graham] Univ Idaho, Coll Educ, Moscow, ID 83844 USA. RP Pickering, MA (reprint author), W Point Mil Acad, Ctr Enhanced Performance, 745A Brewerton Rd, West Point, NY 10996 USA. NR 42 TC 6 Z9 6 U1 2 U2 7 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2010 VL 175 IS 4 BP 213 EP 219 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 582GQ UT WOS:000276585100003 PM 20446495 ER PT J AU Bell, NS Amoroso, PJ Williams, JO Yore, MM Engel, CC Senier, L DeMattos, AC Wegman, DH AF Bell, Nicole S. Amoroso, Paul J. Williams, Jeffrey O. Yore, Michelle M. Engel, Charles C., Jr. Senier, Laura DeMattos, Annette C. Wegman, David H. TI Demographic, Physical, and Mental Health Factors Associated With Deployment of US Army Soldiers to the Persian Gulf SO MILITARY MEDICINE LA English DT Article ID OPERATION-DESERT-STORM; TRAUMA-RELATED SYMPTOMS; WAR VETERANS; POSTTRAUMATIC-STRESS; SELF-REPORTS; ALCOHOL-CONSUMPTION; MILITARY PERSONNEL; CAGE QUESTIONNAIRE; FOLLOW-UP; MORTALITY AB A total of 675,626 active duty Army soldiers who were known to be at risk for deployment to the Persian Gulf were followed from 1980 through the Persian Gulf War. Hospitalization histories for the entire cohort and Health Risk Appraisal surveys for a subset of 374 soldiers were used to evaluate prewar distress, health, and behaviors. Deployers were less likely to have had any prewar hospitalizations or hospitalization for a condition commonly reported among Gulf War veterans or to report experiences of depression/suicidal ideation. Deployers reported greater satisfaction with life and relationships but displayed greater tendencies toward risk taking, such as drunk driving, speeding, and failure to wear safety belts. Deployed veterans were more likely to receive hazardous duty pay and to he hospitalized for an injury than nondeployed Gulf War-era veterans. If distress is a predictor of postwar morbidity, it is likely attributable to experiences occurring during or after the war and not related to prewar exposures or health status. Postwar excess injury risk may be explained in part by a propensity for greater risk taking, which was evident before and persisted throughout the war. C1 [Bell, Nicole S.; Williams, Jeffrey O.; Senier, Laura; DeMattos, Annette C.] SSDC Inc, Natick, MA USA. [Amoroso, Paul J.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Yore, Michelle M.; Engel, Charles C., Jr.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA. [Yore, Michelle M.; Engel, Charles C., Jr.] Walter Reed Army Med Ctr, Deployment Hlth Clin Ctr, Washington, DC 20307 USA. [Wegman, David H.] Univ Massachusetts, Dept Work Environm, Lowell, MA USA. RP Bell, NS (reprint author), SSDC Inc, Natick, MA USA. FU U.S. Army Medical Research Acquisition Activity [DAMD17-98-1-8610]; National Institute on Alcohol Abuse and Alcoholism [1 R29 AA11407-01A1] FX This study was made possible by grant DAMD17-98-1-8610 from the U.S. Army Medical Research Acquisition Activity and by grant 1 R29 AA11407-01A1 from the National Institute on Alcohol Abuse and Alcoholism. NR 41 TC 2 Z9 2 U1 1 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2010 VL 175 IS 4 BP 227 EP 237 PG 11 WC Medicine, General & Internal SC General & Internal Medicine GA 582GQ UT WOS:000276585100005 PM 20446497 ER PT J AU Fulton, LV Devore, RB McMurry, PM AF Fulton, Lawrence V. Devore, Raymond B., Jr. McMurry, Pat M. TI Estimating Sustaining Base-Hospital Personnel Requirements During Extended Operations SO MILITARY MEDICINE LA English DT Article AB This case study provides a unique method for estimating sustaining base military hospital personnel requirements during combat and stability operations while underscoring the need for such analysis before the commencement of combat operations. The requirement estimates are based on a major combat operation (MCO) scenario, which was extended to simulate stability operations. The scenario selected derived from Department of Defense strategic planning guidance as modeled by the Total Army Analysis (TAA). Since casualties experienced in combat result in additional workload for military hospitals, a mechanism for estimating that workload is required. A single scenario generated as part of an analysis for the acting Army surgeon general produced a median requirement of 1,299 additional full-time equivalents (FTEs) over the course of 36 months, highlighting a significant gap between capabilities and requirements. C1 [Fulton, Lawrence V.; Devore, Raymond B., Jr.; McMurry, Pat M.] USA, Med Dept Ctr & Sch, Ctr AMEDD Strateg Studies, Ft Sam Houston, TX 78234 USA. RP Fulton, LV (reprint author), USA, Med Dept Ctr & Sch, Ctr AMEDD Strateg Studies, 1608 Stanley Rd,Suite 47, Ft Sam Houston, TX 78234 USA. NR 8 TC 2 Z9 2 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2010 VL 175 IS 4 BP 238 EP 246 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA 582GQ UT WOS:000276585100006 PM 20446498 ER PT J AU Weber, NS Cowan, DN Bedno, SA Niebuhr, DW AF Weber, Natalya S. Cowan, David N. Bedno, Sheryl A. Niebuhr, David W. TI Descriptive Epidemiology of Bipolar I Disorder Among United States Military Personnel SO MILITARY MEDICINE LA English DT Article ID GENDER-DIFFERENCES; MENTAL-DISORDERS; US MILITARY; ONSET; AGE; MANIA; COMORBIDITY; PREVALENCE; DIAGNOSIS; ETHNICITY AB Psychiatric disorders in military members require substantial medical, administrative, and financial resources, and are among the leading causes of hospitalization and early discharge. We reviewed available data to better understand the incidence of bipolar I disorder among military personnel. Defense Medical Epidemiology Database inpatient data were used. Descriptive and comparative statistics were performed. From 1997-2006 there were 3,317 first hospitalizations for bipolar I disorder with a mean of 1.2 hospitalizations per case. The rate of first occurrence among this adult population was 0.24 per 1,000 person-years. The incidence increased over time or depressed and mixed episode types among both genders. High risk groups include women, younger individuals, and whites. This population provides insight into adult onset bipolar! disorder incidence and demographic patterns not available elsewhere and offers potential opportunities to improve its understanding. C1 [Weber, Natalya S.; Cowan, David N.; Bedno, Sheryl A.; Niebuhr, David W.] Walter Reed Army Inst Res, Dept Epidemiol, Div Prevent Med, Silver Spring, MD 20910 USA. RP Weber, NS (reprint author), Walter Reed Army Inst Res, Dept Epidemiol, Div Prevent Med, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. NR 37 TC 6 Z9 6 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2010 VL 175 IS 4 BP 247 EP 251 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 582GQ UT WOS:000276585100007 PM 20446499 ER PT J AU Platteborze, LS Young-McCaughan, S King-Letzkus, I McClinton, A Halliday, A Jefferson, TC AF Platteborze, Lynn S. Young-McCaughan, Stacey King-Letzkus, Ileana McClinton, Annette Halliday, Ann Jefferson, Thomas C. TI Performance Improvement/Research Advisory Panel: A Model for Determining Whether a Project Is a Performance or Quality Improvement Activity or Research SO MILITARY MEDICINE LA English DT Article AB The determination of whether an activity is performance improvement governed by The Joint Commission standards and local hospital policy or research governed by federal regulation and requiring institutional review board (IRB) review and approval can be complex, especially in academic clinical organizations. Both processes can address scientific validity, fair participant selection, favorable risk-benefit ratio, respect for participants, and independent review. In an attempt to guide staff as to whether their project needs IRB review or not, a performance improvement/research advisory panel (PIRAP) was formed to serve two military organizations. In this article, performance improvement and quality improvement is differentiated from research as much as possible, the composition and function of PIRAP is described, and guidelines for publishing findings that support the nature of the project are provided. C1 [Platteborze, Lynn S.; McClinton, Annette] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Young-McCaughan, Stacey] Univ Texas Hlth Sci Ctr San Antonio, Sch Med, Dept Psychiat, San Antonio, TX 78229 USA. [King-Letzkus, Ileana] Brooke Army Med Ctr, HIPAA Res Compliance, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. [Halliday, Ann] Brooke Army Med Ctr, Dept Qual Serv, Ft Sam Houston, TX 78234 USA. [Jefferson, Thomas C.] Brooke Army Med Ctr, Dept Pediat, Ft Sam Houston, TX 78234 USA. RP Platteborze, LS (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. NR 5 TC 4 Z9 4 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2010 VL 175 IS 4 BP 289 EP 291 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 582GQ UT WOS:000276585100014 PM 20446506 ER PT J AU Lenart, M Buckenmaier, CC Kim, MJ Plunkett, AR AF Lenart, Mark Buckenmaier, Chester C., III Kim, Moon J. Plunkett, Anthony R. TI Development of a Complicated Pain Syndrome Following Cyanide Poisoning in a US Soldier SO MILITARY MEDICINE LA English DT Article ID REFLEX SYMPATHETIC DYSTROPHY; PATIENT; BLOCK AB A majority of modern war wounds are caused by blasts and high-energy ballistics. Extremity injuries predominate since modern body armor does not protect these areas due to mobility limitations. A less known and more insidious mechanism of enemy attack among our soldiers involves treachery by the local populace posing as noncombatants. One such recent event involved the contamination of tobacco with cyanide (CN(-)). We describe a case of a soldier with CN(-) intoxication due to ingestion of tobacco purchased from a local merchant. The soldier developed a complex neuropathic pain syndrome and was successfully treated with an inpatient high-dose intravenous ketamine infusion in combination with continuous peripheral nerve blockade. C1 [Lenart, Mark; Buckenmaier, Chester C., III; Plunkett, Anthony R.] USA, Walter Reed Army Med Ctr, Reg Anaesthesia & Pain Management Initiat, Anaesthesia & Operat Serv, Washington, DC 20307 USA. [Kim, Moon J.] Walter Reed Army Med Ctr, Dept Phys Med & Rehabil, Washington, DC 20307 USA. RP Lenart, M (reprint author), USA, Walter Reed Army Med Ctr, Reg Anaesthesia & Pain Management Initiat, Anaesthesia & Operat Serv, Bldg 2,Ward 44,Room 4418, Washington, DC 20307 USA. NR 15 TC 0 Z9 1 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2010 VL 175 IS 4 BP 292 EP 294 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 582GQ UT WOS:000276585100015 PM 20446507 ER PT J AU Mitchell, JL Chatwell, N Christensen, D Diaper, H Minogue, TD Parsons, TM Walker, B Weller, SA AF Mitchell, Jan L. Chatwell, Nicola Christensen, Deanna Diaper, Helen Minogue, Timothy D. Parsons, Tanya M. Walker, Brian Weller, Simon A. TI Development of real-time PCR assays for the specific detection of Francisella tularensis ssp tularensis, holarctica and mediaasiatica SO MOLECULAR AND CELLULAR PROBES LA English DT Article DE Tularaemia; Real-time PCR; Diagnosis; Francisella tularensis ID SUBSP TULARENSIS; IDENTIFICATION; TULAREMIA; STRAINS; SPECIMENS; AGENT AB Real-time polymerase chain reaction (PCR) assays were developed to detect Francisella tularensis (Ft), the causative agent of tularaemia in humans. Two real-time PCRs (FTT0376 and FTT0523) were designed in genetic sequences identified by the Insignia genome comparison tool (http://insignia.cbcb.umd.edu/) as being unique to pathogenic subspecies of F tularensis. Both PCRs identified all pathogenic E tularensis subspecies but did not cross react with avirulent Francisella philomiragia or F tularensis ssp. novicida or other environmental bacteria. Limits of detection from DNA purified from pure culture (FTT0376 similar to 80 Ft genome equivalents (GEs) per PCR; FTT0523 similar to 20 Ft GEs per PCR;) and DNA purified from spiked blood samples (4 x 10(4) to 4 x 10(3) cfu ml(-1), both assays) were determined. (C) 2009 Published by Elsevier Ltd. C1 [Mitchell, Jan L.; Chatwell, Nicola; Diaper, Helen; Parsons, Tanya M.; Walker, Brian; Weller, Simon A.] Def Sci & Technol Lab, Detect Dept, Salisbury SP4 0JQ, Wilts, England. [Christensen, Deanna; Minogue, Timothy D.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Mitchell, JL (reprint author), Def Sci & Technol Lab, Detect Dept, Salisbury SP4 0JQ, Wilts, England. EM jan.mitchell@salisbury.nhs.uk FU Ministry of Defence (UK) FX The development of the multiplex F tularensis PCR assay was funded by the Ministry of Defence (UK). The authors wish to thank the Technical Cooperation Program, especially Technical Panel 14 and the Detection and Diagnostic Reagents Working Group, for facilitating the collaboration between Dstl and USAMRIID. The UK authors would like to thank David Norwood & Jim Jaissle (USAMRIID) for enabling access to DNA reference panels. Opinions, interpretations, conclusions and recommendations stated in this paper are those of the authors and are not necessarily endorsed by the U.S. Army. NR 22 TC 15 Z9 17 U1 2 U2 11 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0890-8508 J9 MOL CELL PROBE JI Mol. Cell. Probes PD APR PY 2010 VL 24 IS 2 BP 72 EP 76 DI 10.1016/j.mcp.2009.10.004 PG 5 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Cell Biology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Cell Biology GA 566WJ UT WOS:000275403700003 PM 19833196 ER PT J AU Sharlow, ER Grogl, M Johnson, J Lazo, JS AF Sharlow, Elizabeth R. Groegl, Max Johnson, Jacob Lazo, John S. TI Anti-leishmanial Drug Discovery: Rising to the Challenges of a Highly Neglected Disease SO MOLECULAR INTERVENTIONS LA English DT Editorial Material ID CUTANEOUS-LEISHMANIASIS; FUTURE; STRATEGIES; EFFICACY; GROWTH; BURDEN; CELLS C1 [Sharlow, Elizabeth R.; Lazo, John S.] Univ Pittsburgh, Drug Discovery Inst, Pittsburgh, PA 15260 USA. [Sharlow, Elizabeth R.; Lazo, John S.] Univ Pittsburgh, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15260 USA. [Groegl, Max; Johnson, Jacob] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Sharlow, ER (reprint author), Univ Pittsburgh, Drug Discovery Inst, Pittsburgh, PA 15260 USA. EM lazo@pitt.edu NR 31 TC 6 Z9 6 U1 0 U2 4 PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA SN 1534-0384 J9 MOL INTERV JI Mol. Interv. PD APR PY 2010 VL 10 IS 2 BP 72 EP 75 DI 10.1124/mi.10.2.4 PG 4 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 578QO UT WOS:000276309200003 PM 20368366 ER PT J AU Hemmert, AC Otto, TC Wierdl, M Edwards, CC Fleming, CD MacDonald, M Cashman, JR Potter, PM Cerasoli, DM Redinbo, MR AF Hemmert, Andrew C. Otto, Tamara C. Wierdl, Monika Edwards, Carol C. Fleming, Christopher D. MacDonald, Mary Cashman, John R. Potter, Philip M. Cerasoli, Douglas M. Redinbo, Matthew R. TI Human Carboxylesterase 1 Stereoselectively Binds the Nerve Agent Cyclosarin and Spontaneously Hydrolyzes the Nerve Agent Sarin SO MOLECULAR PHARMACOLOGY LA English DT Article ID OXIME-INDUCED REACTIVATION; ORGANOPHOSPHORUS COMPOUNDS; CRYSTAL-STRUCTURES; MAMMALIAN CARBOXYLESTERASES; HUMAN ACETYLCHOLINESTERASE; ACTIVE-CENTER; INHIBITION; PROTECTION; SOMAN; TOXICITY AB Organophosphorus (OP) nerve agents are potent toxins that inhibit cholinesterases and produce a rapid and lethal cholinergic crisis. Development of protein-based therapeutics is being pursued with the goal of preventing nerve agent toxicity and protecting against the long-term side effects of these agents. The drug-metabolizing enzyme human carboxylesterase 1 (hCE1) is a candidate protein-based therapeutic because of its similarity in structure and function to the cholinesterase targets of nerve agent poisoning. However, the ability of wild-type hCE1 to process the G-type nerve agents sarin and cyclosarin has not been determined. We report the crystal structure of hCE1 in complex with the nerve agent cyclosarin. We further use stereoselective nerve agent analogs to establish that hCE1 exhibits a 1700- and 2900-fold preference for the P R enantiomers of analogs of soman and cyclosarin, respectively, and a 5-fold preference for the P S isomer of a sarin analog. Finally, we show that for enzyme inhibited by racemic mixtures of bona fide nerve agents, hCE1 spontaneously reactivates in the presence of sarin but not soman or cyclosarin. The addition of the neutral oxime 2,3-butanedione monoxime increases the rate of reactivation of hCE1 from sarin inhibition by more than 60-fold but has no effect on reactivation with the other agents examined. Taken together, these data demonstrate that hCE1 is only reactivated after inhibition with the more toxic P S isomer of sarin. These results provide important insights toward the long-term goal of designing novel forms of hCE1 to act as protein-based therapeutics for nerve agent detoxification. C1 [Redinbo, Matthew R.] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA. [Hemmert, Andrew C.; Fleming, Christopher D.; Redinbo, Matthew R.] Univ N Carolina, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA. [Otto, Tamara C.; Cerasoli, Douglas M.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, Baltimore, MD USA. [MacDonald, Mary; Cashman, John R.] Human BioMol Res Inst, San Diego, CA USA. [Wierdl, Monika; Edwards, Carol C.; Potter, Philip M.] St Jude Childrens Hosp, Dept Mol Pharmacol, Memphis, TN 38105 USA. RP Redinbo, MR (reprint author), Univ N Carolina, Dept Chem, CB 3290, Chapel Hill, NC 27599 USA. EM redinbo@unc.edu RI Potter, Philip/J-4515-2013 FU National Institutes of Health National Institute of Neurological Disorders and Stroke [NS58089]; National Institutes of Health National Cancer Institute [CA21765]; American Lebanese Syrian Associated Charities FX This work was supported by the National Institutes of Health National Institute of Neurological Disorders and Stroke [Grant NS58089]; the National Institutes of Health National Cancer Institute [Grant CA21765]; and the American Lebanese Syrian Associated Charities. NR 40 TC 29 Z9 31 U1 1 U2 14 PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA SN 0026-895X J9 MOL PHARMACOL JI Mol. Pharmacol. PD APR PY 2010 VL 77 IS 4 BP 508 EP 516 DI 10.1124/mol.109.062356 PG 9 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 571BZ UT WOS:000275725600002 PM 20051531 ER PT J AU Brown, RS Harnish, RA Carter, KM Boyd, JW Deters, KA Eppard, MB AF Brown, Richard S. Harnish, Ryan A. Carter, Kathleen M. Boyd, James W. Deters, Katherine A. Eppard, M. Brad TI An Evaluation of the Maximum Tag Burden for Implantation of Acoustic Transmitters in Juvenile Chinook Salmon SO NORTH AMERICAN JOURNAL OF FISHERIES MANAGEMENT LA English DT Article ID ATLANTIC SALMON; SWIMMING PERFORMANCE; RADIO TRANSMITTERS; PREDATOR AVOIDANCE; COLUMBIA RIVERS; SURVIVAL; TROUT; SMOLTS; GROWTH; WILD AB A substantial percentage of the Pacific salmon Oncorhynchus spp. and steelhead O. mykiss smolts that emigrate to the ocean each year are smaller than 110 mm (fork length). However, relatively few researchers have implanted acoustic transmitters in fish of this size, and none have reported minimum fish lengths below 110 mm for which the tag burden did not negatively influence growth or survival. The influence of a surgically implanted acoustic microtransmitter and a passive integrated transponder (PIT) tag on the growth and survival of hatchery-reared juvenile Chinook salmon was examined over a period of 30 d. Growth and survival were compared between treatment (tagged) and control (untagged) fish within three size-groups (80-89, 90-99, and 100-109 mm). The acoustic microtransmitter and PIT tag implanted in our study had a combined weight of 0.74 g; the combined tag burden for implanted fish ranged from 4.5% to 15.7%. The results indicated that growth and survival among implanted juvenile Chinook salmon were size dependent. Significant differences in growth rate and survival were observed between treatment and control fish in the 80-89-mm group. The survival of implanted fish smaller than 11.1 g (tag burden, >6.7%) and the growth of fish smaller than 9.0 g (tag burden, >8.2%) were negatively affected by the implantation or presence of an acoustic microtransmitter and PIT tag. The results of this study will aid researchers in determining the minimum fish size suitable for use in acoustic telemetry studies that estimate the short-term (30-d) survival and growth of juvenile salmonids. C1 [Brown, Richard S.; Harnish, Ryan A.; Carter, Kathleen M.; Boyd, James W.; Deters, Katherine A.] Pacific NW Natl Lab, Ecol Grp, Richland, WA 99352 USA. [Eppard, M. Brad] US Army Corps Engineers, Portland, OR 97204 USA. RP Brown, RS (reprint author), Pacific NW Natl Lab, Ecol Grp, POB 999, Richland, WA 99352 USA. EM rich.brown@pnl.gov FU U.S. Army Corps of Engineers, Portland District; U.S. Department of Energy [DE-AC05-76RL01830] FX This study was funded by the U.S. Army Corps of Engineers, Portland District. The Pacific Northwest National Laboratory is operated by Battelle for the U.S. Department of Energy under contract DE-AC05-76RL01830. With appreciation, we acknowledge the technical contributions to the project made by the following people from the Pacific Northwest National Laboratory: Brian Bellgraph, Geoffrey McMichael, Jessica Carter, David Geist, Tom Carlson, Abby Welch, Marie Theriault, Garrett McKinney, Jennifer Panther, Katie Ovink, Katie Murray, Gayle Dirkes, Tirell Monter, Ian Welch, Julie Miller, Brooke Sakara, Chris Eilers, Scott Abernethy, Craig McKinstry, and Andrea Currie. We also thank John Skalski of the University of Washington. Our thanks go also to Brad Ryan, Eric Hockersmith, and Michelle Rub of NOAA Fisheries. NR 28 TC 34 Z9 34 U1 0 U2 12 PU AMER FISHERIES SOC PI BETHESDA PA 5410 GROSVENOR LANE SUITE 110, BETHESDA, MD 20814-2199 USA SN 0275-5947 J9 N AM J FISH MANAGE JI North Am. J. Fish Manage. PD APR PY 2010 VL 30 IS 2 BP 499 EP 505 DI 10.1577/M09-038.1 PG 7 WC Fisheries SC Fisheries GA 599XP UT WOS:000277947800014 ER PT J AU Ter-Gabrielyan, N Merkle, LD Kupp, ER Messing, GL Dubinskii, M AF Ter-Gabrielyan, N. Merkle, L. D. Kupp, E. R. Messing, G. L. Dubinskii, M. TI Efficient resonantly pumped tape cast composite ceramic Er:YAG laser at 1645 nm SO OPTICS LETTERS LA English DT Article ID ND-YAG AB Laser operation of a composite ceramic Er:YAG rod is demonstrated at 1645 nm with a slope efficiency of 56.9% under resonant pumping at 1532.3 nm. This is believed to be the first reported composite ceramic Er: YAG laser and also the first reported use of a tape cast technique for producing laser ceramics. C1 [Ter-Gabrielyan, N.; Merkle, L. D.; Dubinskii, M.] USA, Res Lab, RDRL SEE O, Adelphi, MD 20783 USA. [Kupp, E. R.; Messing, G. L.] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. [Kupp, E. R.; Messing, G. L.] Penn State Univ, Mat Res Inst, University Pk, PA 16802 USA. RP Dubinskii, M (reprint author), USA, Res Lab, RDRL SEE O, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM mdubinskiy@arl.army.mil FU High Energy Laser Joint Technology Office [BAA 05-DE-01] FX This work was partially supported by the High Energy Laser Joint Technology Office under BAA 05-DE-01. NR 11 TC 41 Z9 43 U1 2 U2 30 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD APR 1 PY 2010 VL 35 IS 7 BP 922 EP 924 PG 3 WC Optics SC Optics GA 578QP UT WOS:000276309300010 PM 20364170 ER PT J AU Bulatov, D Lavery, JE AF Bulatov, Dimitri Lavery, John E. TI Reconstruction and Texturing of 3D Urban Terrain from Uncalibrated Monocular Images Using L-1 Splines SO PHOTOGRAMMETRIC ENGINEERING AND REMOTE SENSING LA English DT Article ID SURFACE RECONSTRUCTION AB We propose a five-step procedure for reconstruction and texturing of 3D urban terrain based on a novel approach for 3D surface reconstruction from optical images produced by monocular optical cameras on small, inexpensive vehicles without external referencing. The approach consists of generation of a nonparametric 2.5D L-1-spline surface from a point cloud and iterative creation of parametric 3D L-1-spline surfaces based on parametrizations using the previous surface. Computational results for a model house and for Gottesaue Palace in Karlsruhe, Germany are presented. The results presented here are proof of principle results that show that the L-1-spline-based procedure is able to reconstruct and texture 3D urban terrain in spite of the large, abrupt changes in density of the point cloud, and that it produces results that are visually competitive with or superior to competing procedures. Future improvements (finer grids, adaptive grids and parameters, reduction of computing time) are outlined. C1 [Bulatov, Dimitri; Lavery, John E.] FOM, FGAN, Res Inst Optron & Pattern Recognit, Scene Anal Div, D-76275 Ettlingen, Germany. [Lavery, John E.] USA, Res Lab, Army Res Off, Div Math, Res Triangle Pk, NC 27709 USA. RP Bulatov, D (reprint author), FOM, FGAN, Res Inst Optron & Pattern Recognit, Scene Anal Div, Gutleuthausstr 1, D-76275 Ettlingen, Germany. EM bulatov@fom.fgan.de NR 32 TC 9 Z9 9 U1 0 U2 1 PU AMER SOC PHOTOGRAMMETRY PI BETHESDA PA 5410 GROSVENOR LANE SUITE 210, BETHESDA, MD 20814-2160 USA SN 0099-1112 EI 2374-8079 J9 PHOTOGRAMM ENG REM S JI Photogramm. Eng. Remote Sens. PD APR PY 2010 VL 76 IS 4 BP 439 EP 449 PG 11 WC Geography, Physical; Geosciences, Multidisciplinary; Remote Sensing; Imaging Science & Photographic Technology SC Physical Geography; Geology; Remote Sensing; Imaging Science & Photographic Technology GA 577NZ UT WOS:000276231900011 ER PT J AU Litz, MS Merkel, G Pereira, NR Boyer, CN Holland, GE Schumer, JW Seely, JF Hudson, LT Carroll, JJ AF Litz, M. S. Merkel, G. Pereira, N. R. Boyer, C. N. Holland, G. E. Schumer, J. W. Seely, J. F. Hudson, L. T. Carroll, J. J. TI Anomalous fluorescence line intensity in megavoltage bremsstrahlung SO PHYSICS OF PLASMAS LA English DT Article DE bremsstrahlung; fluorescence; plasma diagnostics; tungsten ID KEV ENERGY-RANGE; RAY; ELEMENTS AB An anomalous ratio between K alpha and K beta fluorescence interpreted with plasma radiation modeling can be a useful diagnostic in laser-produced plasmas. In cold tungsten there exists a similar but as yet undocumented anomaly: for 2 MeV end point bremsstrahlung in the forward direction K beta/K alpha(1)similar or equal to 1, while this ratio is closer to 0.5 for bremsstrahlung in reflection and for an isolated atom. As in the laser-produced plasma, the anomalous ratio reflects a localized source of fluorescence inside the material combined with differential attenuation of the fluorescence photons on their way out. To measure the similar or equal to 60 keV fluorescence lines, a Cauchois transmission crystal spectrograph that works well for laser-produced plasmas must suppress the intense bremsstrahlung that accompanies the fluorescence, by beefing up marginal shielding and avoiding extraneous scatter sources. C1 [Litz, M. S.; Merkel, G.] USA, Res Lab, Adelphi, MD 20873 USA. [Pereira, N. R.] Ecopulse Inc, Springfield, VA 22150 USA. [Boyer, C. N.] L3 Commun, Washington, DC 20375 USA. [Holland, G. E.; Hudson, L. T.] Natl Inst Stand & Technol, Gaithersburg, MD 20899 USA. [Schumer, J. W.; Seely, J. F.] USN, Res Lab, Washington, DC 20375 USA. [Carroll, J. J.] Youngstown State Univ, Youngstown, OH 44555 USA. RP Litz, MS (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20873 USA. EM pereira@speakeasy.net RI Schumer, Joseph/D-7591-2013 FU Army Research Laboratory [W911QX07C0002]; DTRA's Basic Research Sciences [MIPR 08-2468, MIPR 09-2156]; Naval Research Laboratory FX This work was supported by the Army Research Laboratory, Ecopulse's Contract No. W911QX07C0002, and by DTRA's Basic Research Sciences Contract Nos. MIPR 08-2468 and MIPR 09-2156 with the Naval Research Laboratory. N.R.P. thanks R. Kensek (SNL) for discussions about ITS. NR 20 TC 5 Z9 5 U1 0 U2 1 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 1070-664X J9 PHYS PLASMAS JI Phys. Plasmas PD APR PY 2010 VL 17 IS 4 AR 043302 DI 10.1063/1.3389226 PG 8 WC Physics, Fluids & Plasmas SC Physics GA 590QV UT WOS:000277243000058 ER PT J AU Naumann, JC Anderson, JE Young, DR AF Naumann, J. C. Anderson, J. E. Young, D. R. TI Remote detection of plant physiological responses to TNT soil contamination SO PLANT AND SOIL LA English DT Article DE Trinitrotoluene; Hyperspectral reflectance; Chlorophyll fluorescence; Photosynthesis ID LEAF CHLOROPHYLL FLUORESCENCE; 2,4,6-TRINITROTOLUENE TNT; HYPERSPECTRAL IMAGERY; MYRICA-CERIFERA; SALINITY STRESS; WATER-STRESS; REFLECTANCE; VEGETATION; INDEXES; TREES AB Our study was aimed at understanding physiological responses to trinitrotoluene (TNT) soil contamination, and using optical methods to detect TNT-induced stress in a woody plant prior to visible changes. Myrica cerifera plants were potted in soil concentrations of TNT ranging from 30-500 mg kg(-1). Physiological measurements were significantly affected by TNT exposure at all treatment levels, and photosynthetic decline likely resulted from metabolic impairment rather than stomatal closure as the experiment progressed. Several reflectance indices were able to detect TNT-induced stress before any changes in chlorophyll concentrations occurred. The most sensitive index was the simple ratio R(761)/R(757) which is linked to fluorescence in-filling of the 0(2) atmospheric absorption. Changes at R(740)/R(850) and R(735)/R(850) may be attributed to both fluorescence and structural characteristics of leaf anatomy in the near infrared region. This could have been influenced by transformation and conjugation of TNT metabolites with other compounds. chlorophyll index (CHL) or in the water band index (WBI(970)), which are indices typically associated with drought stress, and may provide a means of separating stress due to explosives. Further studies need to be conducted with a combination of stressors (TNT and natural) to determine if responses are in fact generalized or if any of these changes are separable from natural stress. C1 [Naumann, J. C.; Anderson, J. E.] USA, Erdc, Fluorescence Spect Lab, Alexandria, VA 22315 USA. [Young, D. R.] Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA. RP Naumann, JC (reprint author), USA, Erdc, Fluorescence Spect Lab, 7701 Telegraph Rd, Alexandria, VA 22315 USA. EM jczinner@vcu.edu FU United States Army Research Office; U.S. Department of Energy; ERDC FX This research was support by a grant to DRY from the United States Army Research Office. Spencer Bissett, Steven Brantley and Kati Rubis provided support with spectral reflectance collection and data processing. This research was also supported in part by an appointment for JCN to the Postgraduate Research Participation Program at the U.S. Army Corps of Engineers/Engineer Research and Development Center (ERDC) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and ERDC. NR 39 TC 10 Z9 10 U1 0 U2 11 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0032-079X J9 PLANT SOIL JI Plant Soil PD APR PY 2010 VL 329 IS 1-2 BP 239 EP 248 DI 10.1007/s11104-009-0148-1 PG 10 WC Agronomy; Plant Sciences; Soil Science SC Agriculture; Plant Sciences GA 568SP UT WOS:000275543300018 ER PT J AU Mabry, RL Edens, JW Pearse, L Kelly, JF Harke, H AF Mabry, Robert L. Edens, Jason W. Pearse, Lisa Kelly, Joseph F. Harke, Howard TI Fatal Airway Injuries during Operation Enduring Freedom and Operation Iraqi Freedom SO PREHOSPITAL EMERGENCY CARE LA English DT Article DE airway; tactical; cricothyroidotomy; Operation Iraqi Freedom; Operation Enduring Freedom; Iraq War; combat ID COMBAT CASUALTY CARE; MAJOR LIMB TRAUMA; SURGICAL CRICOTHYROTOMY; HEMORRHAGE CONTROL; TOURNIQUET USE; UNITED-STATES; DEATH; CRICOTHYROIDOTOMY; MANAGEMENT; SURVIVAL AB Introduction. Airway compromise is the third leading cause of potentially preventable death on the battlefield. An understanding of the injuries associated with fatal airway compromise is necessary to develop improvements in equipment, training, and prehospital management strategies in order to maximize survival. Objective. To determine injury patters resulting in airway compromise in the combat setting. Methods. This was a subgroup analysis of cases previously examined by Kelly and colleagues, who reviewed autopsies of military personnel who died in combat in Iraq and Afghanistan between 2003 and 2006. Casualties with potentially survivable (PS) injuries and deaths related to airway compromise previously identified by Kelly et al. were reviewed in depth by a second panel of military physicians. Results. There were 982 cases that met the inclusion criteria. Of these, 232 cases had PS injuries. Eighteen (1.8%) cases were found to have airway compromise as the likely cause of primary death. All had penetrating injuries to the face or neck. Twelve deaths (67%) were caused by gunshot wounds, while six deaths (33%) were caused by explosions. Nine cases had concomitant injury to major vascular structures, and eight had significant airway hemorrhage. Cricothyroidotomy was attempted in five cases; all were unsuccessful. Conclusion. Airway compromise from battlefield trauma results in a small number of PS fatalities. Penetrating trauma to the face or neck may be accompanied by significant hemorrhage, severe and multiple facial fractures, and airway disruption, leading to death from airway compromise. Cricothyroidotomy may be required to salvage these patients, but the procedure failed in all instances in this series of cases. Further studies are warranted to determine the appropriate algorithm of airway management in combat casualties sustaining traumatic airway injuries. C1 [Mabry, Robert L.] USA, Dept Combat Med Training, ATTN MCCS HW, Ft Sam Houston, TX 78114 USA. [Edens, Jason W.; Kelly, Joseph F.] USA, Inst Surg Res, Ft Sam Houston, TX 78114 USA. [Pearse, Lisa; Harke, Howard] Off Armed Forces Med Examiner, Rockville, MD USA. RP Mabry, RL (reprint author), USA, Dept Combat Med Training, ATTN MCCS HW, 3151 WW White, Ft Sam Houston, TX 78114 USA. EM robert.mabry@us.army.mil NR 23 TC 19 Z9 20 U1 0 U2 2 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1090-3127 J9 PREHOSP EMERG CARE JI Prehosp. Emerg. Care PD APR-JUN PY 2010 VL 14 IS 2 BP 272 EP 277 DI 10.3109/10903120903537205 PG 6 WC Emergency Medicine; Public, Environmental & Occupational Health SC Emergency Medicine; Public, Environmental & Occupational Health GA 563SW UT WOS:000275155100021 PM 20199236 ER PT J AU Gao, XG Ray, R Xiao, Y Ishida, K Ray, P AF Gao, Xiugong Ray, Radharaman Xiao, Yan Ishida, Keiko Ray, Prabhati TI Macrolide antibiotics improve chemotactic and phagocytic capacity as well as reduce inflammation in sulfur mustard-exposed monocytes SO PULMONARY PHARMACOLOGY & THERAPEUTICS LA English DT Article DE Macrolide antibiotic; Chemotaxis; Phagocytosis; Inflammation; Sulfur mustard; Monocyte ID OBSTRUCTIVE PULMONARY-DISEASE; NORMAL HUMAN KERATINOCYTES; AIRWAY EPITHELIAL-CELLS; NITRIC-OXIDE SYNTHASE; NF-KAPPA-B; ALVEOLAR MACROPHAGES; CYTOKINE RELEASE; MOUSE SKIN; AZITHROMYCIN; EXPRESSION AB Background: Sulfur mustard (SM) inhalation causes apoptosis and death of airway epithelial cells as well as inflammation in the airway. Efficient clearance of the cell debris by alveolar macrophages is necessitated to reduce the inflammation. Macrolide antibiotics have been reported to have anti-inflammatory properties by modulating the production of proinflammatory cytokines and mediators, and by improving macrophage functions. The present study investigated the effects of four commonly used macrolide antibiotics, namely azithromycin, clarithromycin, erythromycin, and roxithromycin, on chemotactic and phagocytotic function and on inflammatory cytokines/mediators production in vitro in SM-exposed monocyte THP-1 cells. Results: Chemotaxis and phagocytosis of the monocytes reduced upon exposure to 10 mu M SM (8.1% and 17.5%, respectively) were restored by treatment with 10 mu M of any of the four macrolides. Overexpression of inflammatory cytokines following SM exposure was decreased by 50-70% with macrolide treatment. Similarly, exaggerated iNOS expression and nitric oxide (NO) production induced by SM exposure was largely inhibited by treatment with macrolides. Conclusion: The data demonstrate that macrolide antibiotics were effective in improving the degenerated chemotactic and phagocytotic functions of monocytes following SM exposure, and in reducing SM-induced overproduction of proinflammatory cytokines and mediators. Thus, treatment with macrolide antibiotics may lead to improved clearance of apoptotic material in the airway and ultimately result in reduced airway inflammation and injury caused by SM inhalation, suggesting that macrolide antibiotics may serve as potential vesicant respiratory therapeutics. Published by Elsevier Ltd. C1 [Gao, Xiugong; Ishida, Keiko; Ray, Prabhati] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Ray, Radharaman] USA, Med Res Inst Chem Def, Div Res, Aberdeen Proving Ground, MD 21010 USA. [Xiao, Yan] Natl Inst Stand & Technol, Div Biochem Sci, Gaithersburg, MD 20899 USA. RP Ray, P (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM xiugong.gao@amedd.army.mil; radharaman.ray@amedd.army.mil; yan.xiao@nist.gov; keikoishida71@yahoo.com; prabhati.ray@amedd.army.mil FU Defense Threat Reduction Agency [3.F0003_05_WR_C] FX This work was supported by the Defense Threat Reduction Agency (DTRA) Project No. 3.F0003_05_WR_C. We thank Dr. Hiroshi Ishida (Walter Reed Army Institute of Research) for helpful discussions and Dr. Peter E. Barker (National Institute of Standards and Technology) for advice on immunocytochemical study. We also thank Ms. Betty Benton (US Army Medical Research Institute of Chemical Defense) for technical assistance with sulfur mustard exposure. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting true views of the US Army or the Department of Defense. Certain commercial equipment or materials are identified in this paper in order to specify adequately the experimental procedures. Such identification does not imply recommendation or endorsement by the National Institute of Standards and Technology, nor does it imply that the materials or equipment identified are necessarily the best available for the purpose. NR 51 TC 28 Z9 29 U1 0 U2 0 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 1094-5539 J9 PULM PHARMACOL THER JI Pulm. Pharmacol. Ther. PD APR PY 2010 VL 23 IS 2 BP 97 EP 106 DI 10.1016/j.pupt.2009.10.010 PG 10 WC Pharmacology & Pharmacy; Respiratory System SC Pharmacology & Pharmacy; Respiratory System GA 566FY UT WOS:000275356700005 PM 19895898 ER PT J AU Deng, ZQ Weiland, M Carlson, T Eppard, MB AF Deng, Zhiqun Weiland, Mark Carlson, Thomas Eppard, M. Brad TI Design and Instrumentation of a Measurement and Calibration System for an Acoustic Telemetry System SO SENSORS LA English DT Article DE underwater transducers; piezoelectric sensors; acoustic telemetry AB The Juvenile Salmon Acoustic Telemetry System (JSATS) is an active sensing technology developed by the U. S. Army Corps of Engineers, Portland District, for detecting and tracking small fish. It is used primarily for evaluating behavior and survival of juvenile salmonids migrating through the Federal Columbia River Power System to the Pacific Ocean. It provides critical data for salmon protection and development of more "fishfriendly" hydroelectric facilities. The objective of this study was to design and build a Measurement and Calibration System (MCS) for evaluating the JSATS components, because the JSATS requires comprehensive acceptance and performance testing in a controlled environment before it is deployed in the field. The MCS consists of a reference transducer, a water test tank lined with anechoic material, a motion control unit, a reference receiver, a signal conditioner and amplifier unit, a data acquisition board, MATLAB control and analysis interface, and a computer. The fully integrated MCS has been evaluated successfully at various simulated distances and using different encoded signals at frequencies within the bandwidth of the JSATS transmitter. The MCS provides accurate acoustic mapping capability in a controlled environment and automates the process that allows real-time measurements and evaluation of the piezoelectric transducers, sensors, or the acoustic fields. The MCS has been in use since 2009 for acceptance and performance testing of, and further improvements to, the JSATS. C1 [Deng, Zhiqun; Weiland, Mark; Carlson, Thomas] Pacific NW Natl Lab, Richland, WA 99332 USA. [Eppard, M. Brad] USA, Corps Engineers, Portland, OR 97208 USA. RP Deng, ZQ (reprint author), Pacific NW Natl Lab, POB 999, Richland, WA 99332 USA. EM zhiqun.deng@pnl.gov; Mark.Weiland@pnl.gov; thomas.carlson@pnl.gov; Matthew.B.Eppard@usace.army.mil RI Deng, Daniel/A-9536-2011 OI Deng, Daniel/0000-0002-8300-8766 FU U.S. Army Corps of Engineers, Portland District FX The work described in this article was conducted at Pacific Northwest National Laboratory (PNNL) in Richland, Washington, which is operated by Battelle for the U. S. Department of Energy. The authors thank Eric Choi, Brian LaMarche, Geoff McMichael, Brian Noland, and Tom Seim of PNNL for their help with this study. Andrea Currie, Jayson Martinez, and Tao Fu of PNNL provided comments and technical help preparing the manuscript. This study was funded by the U.S. Army Corps of Engineers, Portland District. NR 11 TC 19 Z9 19 U1 0 U2 7 PU MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI PI BASEL PA KANDERERSTRASSE 25, CH-4057 BASEL, SWITZERLAND SN 1424-8220 J9 SENSORS-BASEL JI Sensors PD APR PY 2010 VL 10 IS 4 BP 3090 EP 3099 DI 10.3390/s100403090 PG 10 WC Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation SC Chemistry; Electrochemistry; Instruments & Instrumentation GA 589OI UT WOS:000277159700032 PM 22319288 ER PT J AU Currano, LJ Yu, M Balachandran, B AF Currano, Luke J. Yu, Miao Balachandran, Balakumar TI Latching in a MEMS shock sensor: Modeling and experiments SO SENSORS AND ACTUATORS A-PHYSICAL LA English DT Article DE Shock sensor; Acceleration switch; Threshold; Latching; Reduced-order model; Inertial switch AB Modeling, numerical, and experimental efforts undertaken to develop a fundamental understanding of latching in a MEMS shock sensor are presented. A two degree-of-freedom model is developed and numerical studies are conducted with this model. These studies, which help shed light on difficult to observe experimental aspects, are used to examine the interaction forces between the shock sensor mass and latch, bounce effects, and loss of contact between the mass and the latch. High-speed video images of the shock sensor motions collected during a latching event are shown, and these results are used to verify the model predictions. Parametric studies conducted to examine the sensitivity of the design to friction and the effects of the latch mass and stiffness properties on the latch bounce are presented and discussed. Published by Elsevier B.V. C1 [Currano, Luke J.] USA, Res Lab, RDRL SER L, Adelphi, MD 20783 USA. [Currano, Luke J.; Yu, Miao; Balachandran, Balakumar] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. RP Currano, LJ (reprint author), USA, Res Lab, RDRL SER L, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM luke.currano@us.army.mil RI Yu, Miao/M-6252-2013 OI Yu, Miao/0000-0003-4180-5094 NR 15 TC 28 Z9 31 U1 0 U2 9 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0924-4247 J9 SENSOR ACTUAT A-PHYS JI Sens. Actuator A-Phys. PD APR PY 2010 VL 159 IS 1 BP 41 EP 50 DI 10.1016/j.sna.2010.02.008 PG 10 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 596CP UT WOS:000277661800006 ER PT J AU Batchinsky, AI Jordan, BS Necsoiu, C Dubick, MA Cancio, LC AF Batchinsky, Andriy I. Jordan, Bryan S. Necsoiu, Corina Dubick, Michael A. Cancio, Leopoldo C. TI DYNAMIC CHANGES IN SHUNT AND VENTILATION-PERFUSION MISMATCH FOLLOWING EXPERIMENTAL PULMONARY CONTUSION SO SHOCK LA English DT Article DE Pulmonary contusion; true shunt; multiple inert gas elimination technique; computed tomography ID RESPIRATORY-DISTRESS-SYNDROME; VITRO THROMBELASTOGRAPHY MEASUREMENTS; DILUTIONAL HYPOTHERMIC COAGULOPATHY; LIFE-THREATENING COAGULOPATHY; TRAUMA PATIENT HYPOTHERMIA; VIVO BLEEDING-TIME; COMBAT CASUALTIES; INHALATION INJURY; PROTHROMBIN TIME; GAS-EXCHANGE AB The objective of this study was to investigate early changes in oxygenation by means of the multiple inert gas elimination technique and in coagulation by means of thromboelastography (TEG) after right-sided pulmonary contusion (PC) in swine. Anesthetized swine (group 1; n = 8) sustained a right-chest PC by a captive-bolt stunner. Multiple inert gas elimination technique, TEG, and thoracic computed tomography (CT) scans were performed before and 10, 30, 60, and 120 min after injury. Three-dimensional CT scan reconstruction enabled measurement of volumes of poorly (Vol(Poor)) and nonaerated (Vol(Non)) lung. Eight animals (group 0) were used as uninjured controls. Pulmonary contusion led to sustained tachycardia and transient hypotension. Partial pressure of arterial oxygen (PaO(2)) decreased from 83.9 +/- 4.2 mmHg at baseline to 51.3 +/- 2.8 mmHg 10 min after PC (P < 0.001). Vol(Poor) and Vol(Non) on the right increased significantly after PC, followed by gradual progression in injury marked by decreased Vol(Poor) and increased Vol(Non). By the multiple inert gas elimination technique, blood flow to the true shunt compartment increased from 4.4% +/- 1.0% at baseline to 21.2% +/- 4.9% 10 min after PC, P < 0.001, peaked at 33.2% +/- 7.5% 30 min after PC, P < 0.001, and remained significantly higher compared with controls. Transient increase in blood flow to low and very low ventilation-perfusion (V/Q) compartments was also seen. Clot reaction time and formation rate by TEG increased at 2 h after PC. True shunt is the major cause of hypoxemia after PC, but V/Q mismatch also contributes significantly early after injury. By CT, PC leads to significant loss of functional lung volume on the side of injury. A mild hypocoagulable state was identified 2 h after injury. C1 [Batchinsky, Andriy I.; Jordan, Bryan S.; Necsoiu, Corina; Dubick, Michael A.; Cancio, Leopoldo C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Batchinsky, AI (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM andriy.batchinsky@amedd.army.mil RI Necsoiu, Corina/A-6255-2013 FU Combat Casualty Care Research Program; Telemedicine and Advanced Technology Research Center, US Army Medical Research and Materiel Command FX Funded by the Combat Casualty Care Research Program and the Telemedicine and Advanced Technology Research Center, US Army Medical Research and Materiel Command. NR 34 TC 11 Z9 11 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD APR PY 2010 VL 33 IS 4 BP 419 EP 425 DI 10.1097/SHK.0b013e3181b8bcd9 PG 7 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 575BG UT WOS:000276037700013 PM 20407408 ER PT J AU Loffredo, E Palazzo, AJ Senesi, N Clapp, CE Bashore, TL AF Loffredo, Elisabetta Palazzo, Antonio J. Senesi, Nicola Clapp, C. Edward Bashore, Terry L. TI Germination and Early Growth of Slickspot Peppergrass (Lepidium papilliferum) as Affected by Desert Soil Humic Acids SO SOIL SCIENCE LA English DT Article DE Slickspot peppergrass; soil humic acids; germination; early growth ID BRASSICACEAE AB Slickspot peppergrass (Lepidium papilliferum) is a biennial, or possibly perennial, endemic plant growing in the Southern Idaho high desert in visually distinct small-scale depressions in soils that collect water (so-called slickspots). Lepidium papilliferum establishes seed banks not germinating the first year but remaining dormant and viable for several years. Humic acids (HA) are universally considered to be the most important, abundant, and biologically and chemically active fractions of soil organic matter and are known to affect plant growth by various mechanisms, depending on their origin, nature, and concentration. The effects of HA in slickspot soils and how they relate to the possibility of being a factor in restoring native plants is only partially known. Thus, the objective of this study was to identify and evaluate the effects of HA isolated from three different layers within the soil pro. le (silt, vesicular, and clay) from inside a representative slickspot on the germination and early growth of slickspot peppergrass. Furthermore, these effects were tentatively related to the chemical, physicochemical, compositional, structural, and functional characteristics of the HA. Results of statistical analysis showed that both the type and concentration of the three HA examined exert a highly significant or significant effect on the germination and early growth of slickspot peppergrass as a function of the soil depth from which the HA originated in the slickspot. In particular, germination seemed to be enhanced, especially at higher concentrations, by the less hydrophobic HA, rich in oxygen and total sugars, present in the bottom clay soil layer, whereas root growth and shoot growth were positively influenced by the more hydrophobic and probably more polycondensed HA, rich in C, H, N, and phenolic OH present in the top layer rich in silt. C1 [Loffredo, Elisabetta; Senesi, Nicola] Univ Bari, Dipartimento Biol & Chim Agroforestale & Ambienta, I-70126 Bari, Italy. [Palazzo, Antonio J.] ERDC CRREL, Hanover, NH USA. [Clapp, C. Edward] USDA ARS, St Paul, MN USA. [Clapp, C. Edward] Univ Minnesota, St Paul, MN 55108 USA. [Bashore, Terry L.] Airfield Operat Div, HQ ACC A3A, Langley AFB, VA USA. RP Loffredo, E (reprint author), Univ Bari, Dipartimento Biol & Chim Agroforestale & Ambienta, I-70126 Bari, Italy. EM loffredo@agr.uniba.it OI Loffredo, Elisabetta/0000-0003-0783-5193 FU U.S. Army European Research Office, London, England [N62558-03-M-0010]; USACE Engineer Research and Development Center (ERDD) [A896] FX This work was supported by the Research Contract No. N62558-03-M-0010 of the U.S. Army European Research Office, London, England. The authors acknowledge the funding support from the USACE Engineer Research and Development Center (ERDD) A896 RDT&E program in the project entitled Influence of Seedbanks on the Emergence of Buried Seeds to Predict Future Populations of Invasive and Endangered Species under the Habitat-Centric Species at Risk (SAR) Research to Avoid Future Training Restrictions work package. This work is part of a study on Recovery and Management of Slickspot Peppergrass (Lepidium papilliferum) at the Air Force Juniper Butte Training Range, ID, Classification, Seed Viability, and the Role of Slickspots, funded by the Airspace, Ranges, and Air field Operations Division, HQ Air Combat Command, Langley AFB, VA. The opinions and conclusions in this article are those of the authors and do not necessarily reject those of the U. S. Air Force, United States Army, or the federal government. NR 20 TC 4 Z9 4 U1 3 U2 18 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-075X J9 SOIL SCI JI Soil Sci. PD APR PY 2010 VL 175 IS 4 BP 186 EP 193 DI 10.1097/SS.0b013e3181d9942e PG 8 WC Soil Science SC Agriculture GA 587WT UT WOS:000277027400005 ER PT J AU Cohen, SP Kapoor, SG Nguyen, C Anderson-Barnes, VC Brown, C Schiffer, D Turabi, A Plunkett, A AF Cohen, Steven P. Kapoor, Shruti G. Nguyen, Cuong Anderson-Barnes, Victoria C. Brown, Charlie Schiffer, Dominique Turabi, Ali Plunkett, Anthony TI Neck Pain During Combat Operations An Epidemiological Study Analyzing Clinical and Prognostic Factors SO SPINE LA English DT Article DE combat; military; neck pain; outcome predictor; war ID 2000-2010 TASK-FORCE; RISK-FACTORS; BACK-PAIN; GENERAL-POPULATION; OFFICE WORKERS; IRAQI FREEDOM; DISORDERS; RETURN; DETERMINANTS; PREVALENCE AB Study Design. Prospective observational study among soldiers medically evacuated out of theaters of combat operations for neck pain, with retrospective analysis of variables associated with return-to-duty. Objectives. To provide an epidemiological overview of the burden of neck pain in deployed soldiers involved in combat operations and to identify factors associated with return-to-duty. Summary of Background Data. Neck pain represents one of the leading causes of medical evacuation out of theaters of combat operations. Yet when compared to other diagnostic categories, treatment outcomes, militarily defined as returning a soldier to duty, remain appallingly low. Methods. Demographic, military-specific, and outcome data were prospectively collected over a 2-week period at the Deployed Warrior Medical Management Center in Germany on 374 consecutive soldiers medically evacuated out of theaters of combat operations for a primary diagnosis pertaining to neck pain between 2004 and 2007. The 2-week period represents the maximal allowable time an evacuated soldier can spend in treatment before disposition (i.e., return to theater or evacuate to United States) is rendered. Electronic medical records were reviewed to examine the effect the following variables had on the categorical outcome measure, return-to-unit: age, gender, service-affiliation, rank and seniority, smoking history, coexisting psychiatric diagnosis, prior neck pain, mechanism of injury, whether or not the injury was combat-related, presence of headache, quality of symptoms, correlation with radiologic imaging, and referral to pain specialist. Results. Only 14% of service members returned to their units. Significant correlations were found between female gender and non-army service affiliation, and a service member returning to their unit. Weak trends toward returning to duty were noted for nonsmokers, absence of prior neck pain, concomitant psychiatric diagnosis, corresponding complaints of headache, and referral to a pain specialist. Conclusion. The treatment of service members medically evacuated for neck pain at the main receiving center, the level IV military treatment facility in Landstuhl, Germany, is associated with a low return-to-unit rate. Future studies should consider whether treating personnel predisposed towards a positive outcome with the limited resources available can improve return-to-duty rates. C1 [Cohen, Steven P.; Kapoor, Shruti G.; Brown, Charlie] Johns Hopkins Sch Med, Dept Anesthesiol, Baltimore, MD USA. [Cohen, Steven P.; Turabi, Ali; Plunkett, Anthony] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Nguyen, Cuong] Landstuhl Reg Med Ctr, Phys Med & Rehabil Serv, Dept Surg, Landstuhl, Germany. [Anderson-Barnes, Victoria C.] Walter Reed Army Med Ctr, Dept Orthoped Surg & Rehabil, Washington, DC 20307 USA. [Schiffer, Dominique] Univ Colorado, Sch Med, Dept Anesthesiol, Denver, CO USA. RP Cohen, SP (reprint author), 550 N Broadway,Suite 301, Baltimore, MD 21029 USA. EM scohen40@jhmi.edu FU John P. Murtha Neuro-science and Pain Institute, Johnstown, PA; US Army; Army Regional Anesthesia & Pain Medicine Initiative, Washington, DC FX Supported by a Congressional Grant from the John P. Murtha Neuro-science and Pain Institute, Johnstown, PA; the US Army; and the Army Regional Anesthesia & Pain Medicine Initiative, Washington, DC. NR 22 TC 10 Z9 10 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD APR 1 PY 2010 VL 35 IS 7 BP 758 EP 763 DI 10.1097/BRS.0b013e3181bb11a8 PG 6 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 585NV UT WOS:000276833500007 PM 20228712 ER PT J AU Kashani, MD Eliasson, AH Hoffman, JA Vernalis, MN AF Kashani, Mariam D. Eliasson, Arn H. Hoffman, Jacqueline A. Vernalis, Marina N. TI Assessing Perceived Stress Provides Targets for Stroke Prevention SO STROKE LA English DT Meeting Abstract CT International Stroke Conference CY FEB 23-26, 2010 CL San Antonio, TX SP Amer Heart Assoc, Amer Stroke Assoc C1 [Kashani, Mariam D.; Eliasson, Arn H.; Hoffman, Jacqueline A.; Vernalis, Marina N.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0039-2499 J9 STROKE JI Stroke PD APR PY 2010 VL 41 IS 4 BP E292 EP E292 PG 1 WC Clinical Neurology; Peripheral Vascular Disease SC Neurosciences & Neurology; Cardiovascular System & Cardiology GA 575XU UT WOS:000276106100397 ER PT J AU Natesan, S Baer, DG Walters, TJ Babu, M Christy, RJ AF Natesan, Shanmugasundaram Baer, David G. Walters, Thomas J. Babu, Mary Christy, Robert J. TI Adipose-Derived Stem Cell Delivery into Collagen Gels Using Chitosan Microspheres SO TISSUE ENGINEERING PART A LA English DT Article ID HUMAN BONE-MARROW; REGENERATIVE MEDICINE; IN-VITRO; STROMAL CELLS; TISSUE REPAIR; LINEAGE CELLS; DIFFERENTIATION; VIVO; SCAFFOLD; THERAPY AB Integration of stem cells to injured tissues requires an appropriate delivery device and scaffolding system. In the present study we have developed an in vitro strategy to load and release adipose-derived mesenchymal stem cells (ASC) from chitosan microspheres (CSM) into a collagen gel scaffold. Porous CSM of uniform size and composition were prepared and used as a stem cell carrier. ASC were allowed to attach to the microspheres and infiltrate through the microsphere pores. The number of viable cells was counted in vitro, using MTT and Calcein acetoxymethyl ester ( AM) assays, and it showed a proportional increase with seeding density and reached a maximum cell number by 24 h. The cells inside the microspheres remained metabolically active and viable, could be retrieved from the spheres, and maintained expression of stem-cell-specific markers. Electron microscopic evaluation of the cell-microsphere complex showed that the CSM were able to support cell attachment and that the cells had infiltrated into the pores of the microspheres. The ability of the cells to proliferate and differentiate into adipogenic- and osteogenic-like precursors indicates that the cells have maintained their multipotency after migration out of the microspheres. To mimic cell delivery into a tissue, ASC-loaded CSM were embedded in type-1 collagen scaffold by mixing them with type-1 collagen solution while inducing gelation. By 14 days the cells released into the collagen gel and were able to populate the entire scaffold. When observed through transmission electron microscopy, the cells align along the collagen fibrils with a characteristic fibroblast-like morphology. This study provides a model to capture pluripotent stem cells, expand their cell number within a biomaterial scaffold in vitro, and deliver within an appropriate matrix to repair damaged tissue. C1 [Natesan, Shanmugasundaram; Baer, David G.; Walters, Thomas J.; Christy, Robert J.] USA, Inst Surg Res, Regenerat Med Res Program, Ft Sam Houston, TX 78234 USA. [Babu, Mary] Cent Leather Res Inst, Madras 600020, Tamil Nadu, India. RP Christy, RJ (reprint author), USA, Inst Surg Res, Regenerat Med Res Program, 3400 Rawley Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM robert.christy@amedd.army.mil OI Natesan, Shanmugasundaram/0000-0003-4213-3111 FU University of Texas Health Science Center, San Antonio, TX [NIH-NCI P30 CA54174, NIH-NIA P30 AG013319, NIH-NIA P01AG19316] FX The authors would like to thank Ms. Janet Roe for isolation of adipose tissue and technical support. S.N. was supported by a Postdoctoral Fellowship Grant from the Pittsburgh Tissue Engineering Initiative. Confocal images were generated in the core optical imaging facility, which is supported by the University of Texas Health Science Center, San Antonio, TX, NIH-NCI P30 CA54174 ( San Antonio Cancer Institute), NIH-NIA P30 AG013319 (Nathan Shock Center, San Antonio, TX), and NIH-NIA P01AG19316. The authors also thank Dr. Robert Reddick, Medical Director, and Lauren Chesnut, Technical Director, Electron Microscopy Facility, Department of Pathology, the University of Texas Health Science Center, San Antonio, TX, for use of facility and assistance in the analysis of electron micrographs. NR 58 TC 31 Z9 31 U1 1 U2 11 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1937-3341 J9 TISSUE ENG PT A JI Tissue Eng. Part A PD APR PY 2010 VL 16 IS 4 BP 1369 EP 1384 DI 10.1089/ten.tea.2009.0404 PG 16 WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology SC Cell Biology; Biotechnology & Applied Microbiology GA 579GJ UT WOS:000276356700024 PM 19916819 ER PT J AU Merritt, EK Hammers, DW Tierney, M Suggs, LJ Walters, TJ Farrar, RP AF Merritt, Edward K. Hammers, David W. Tierney, Matthew Suggs, Laura J. Walters, Thomas J. Farrar, Roger P. TI Functional Assessment of Skeletal Muscle Regeneration Utilizing Homologous Extracellular Matrix as Scaffolding SO TISSUE ENGINEERING PART A LA English DT Article ID ABDOMINAL-WALL DEFECTS; OPERATION-IRAQI-FREEDOM; ACELLULAR MATRIX; BONE-MARROW; MOUSE MODEL; STEM-CELL; IN-VIVO; REPAIR; RAT; LACERATION AB The loss of a portion of skeletal muscle poses a unique challenge for the normal regeneration of muscle tissue. A transection injury with tissue loss will not heal due to the gap between muscle segments. A damage model was developed by removing a portion of the lateral gastrocnemius (GAS) of Sprague-Dawley rats. Maximal isometric, tetanic tension (P-o) was measured after the removal of either a small defect (0.5 x 1.0 cm) or a large defect (1.0 x 1.0 cm) piece of the GAS. In situ P-o immediately after creation of the defect was 88.3 +/- 2.0% of the non-operated contralateral GAS force for small defect and 76.9 +/- 3.2% of control for large defect. No functional recovery occurred in either group over the course of 28 days. To enhance recovery, a homologous, decellularized, muscle extracellular matrix (ECM) was implanted into the 1 x 1 cm defect of the lateral GAS of Lewis rats. After 42 days, growth of blood vessels and myofibers into the ECM was apparent, but no restoration of P-o occurred. These data demonstrate the ability of the ECM to support muscle and blood vessel regeneration, but full recovery of function does not occur after 42 days. C1 [Merritt, Edward K.; Hammers, David W.; Tierney, Matthew; Farrar, Roger P.] Univ Texas Austin, Dept Kinesiol, Austin, TX 78712 USA. [Suggs, Laura J.] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA. [Walters, Thomas J.] USA, Inst Surg Res, Dept Regenerat Med, Ft Sam Houston, TX 78234 USA. RP Farrar, RP (reprint author), Univ Texas Austin, Dept Kinesiol, 1 Univ Stn D3700, Austin, TX 78712 USA. EM rfarrar@mail.utexas.edu FU U.S. Army MRMC [DAMD W81XWH-06-1-0540] FX This work was funded by the U.S. Army MRMC Grant DAMD W81XWH-06-1-0540. NR 42 TC 54 Z9 54 U1 0 U2 5 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1937-3341 J9 TISSUE ENG PT A JI Tissue Eng. Part A PD APR PY 2010 VL 16 IS 4 BP 1395 EP 1405 DI 10.1089/ten.tea.2009.0226 PG 11 WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology SC Cell Biology; Biotechnology & Applied Microbiology GA 579GJ UT WOS:000276356700026 PM 19929169 ER PT J AU Naumann, JC Bissett, SN Young, DR Edwards, J Anderson, JE AF Naumann, Julie C. Bissett, Spencer N. Young, Donald R. Edwards, Jarrod Anderson, John E. TI Diurnal patterns of photosynthesis, chlorophyll fluorescence, and PRI to evaluate water stress in the invasive species, Elaeagnus umbellata Thunb. SO TREES-STRUCTURE AND FUNCTION LA English DT Article DE Elaeagnus; PRI; Fluorescence; Photosynthesis; Chlorophyll; Drought stress ID NET CO2 ASSIMILATION; DESERT SHRUB; ENERGY-DISSIPATION; ENCELIA-FARINOSA; LEAF PUBESCENCE; C-3 PLANTS; EFFICIENCY; LEAVES; STATE; PHOTOPROTECTION AB Photosynthesis, chlorophyll fluorescence, and hyperspectral reflectance were used to evaluate diurnal changes of Elaeagnus umbellata to quantify physiological responses of the invasive species during times of stress. Field measurements showed that E. umbellata is able to maintain higher levels of photosynthesis relative to nearby Quercus alba plants, with less water loss. Plants subjected to progressive drought were able to recover photosynthesis one day following re-watering. Laboratory and field measurements revealed decreasing Delta F/F'(m) values in response to drought stress, with little corresponding decrease in photochemical reflectance index values. This research supports the view that xanthophyll cycle dissipation is not the photoprotective mechanism at work for Elaeagnus species under water stress. Elaeagnus umbellata maintains photosynthetic carbon assimilation even under drought conditions, in part, due to chemical dissipation of excess light, and in part because of morphological features that limit excess radiation while maximizing photosynthetic carbon gain. These characteristics may contribute to the invasive success of E. umbellata. C1 [Naumann, Julie C.; Edwards, Jarrod; Anderson, John E.] US Army, Erdc, Fluorescence Spect Lab, Alexandria, VA 22315 USA. [Naumann, Julie C.; Bissett, Spencer N.; Young, Donald R.] Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA. RP Naumann, JC (reprint author), US Army, Erdc, Fluorescence Spect Lab, 7701 Telegraph Rd, Alexandria, VA 22315 USA. EM jczinner@vcu.edu FU United States Army Research Office; U.S. Army Corps of Engineers/Engineer Research and Development Center (ERDC) FX The authors thank Cody Connolly, Sheri Shiflett, and Ellen Young for help with field and laboratory measurements. This research was support by a grant to DRY from the United States Army Research Office. This research was also supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Corps of Engineers/Engineer Research and Development Center (ERDC) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and ERDC. NR 36 TC 11 Z9 12 U1 5 U2 30 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0931-1890 J9 TREES-STRUCT FUNCT JI Trees-Struct. Funct. PD APR PY 2010 VL 24 IS 2 BP 237 EP 245 DI 10.1007/s00468-009-0394-0 PG 9 WC Forestry SC Forestry GA 570QZ UT WOS:000275694400003 ER PT J AU Hakami, RM Ruthel, G Stahl, AM Bavari, S AF Hakami, Ramin Mollaaghababa Ruthel, Gordon Stahl, Andrea M. Bavari, Sina TI Gaining ground: assays for therapeutics against botulinum neurotoxin SO TRENDS IN MICROBIOLOGY LA English DT Review ID TOXIN TYPE-A; SMALL-MOLECULE INHIBITORS; SEROTYPE-B; CLOSTRIDIAL NEUROTOXINS; CONFORMATIONAL-CHANGES; PROTEASE ACTIVITY; LIGHT-CHAIN; IN-VIVO; SUBSTRATE; IDENTIFICATION AB Owing in part to recently heightened concern over bio-terrorism, interest in the mechanism of action of botulinum neurotoxin (BoNT) and development of effective therapeutic strategies has dramatically increased. The emergence of BoNT as an effective treatment for a variety of neurological disorders and its growing use in the cosmetic industry have also increased interest in developing effective countermeasures. Although recent attempts to create effective vaccines appear promising, the multitude of clinical and cosmetic uses of BoNT make mass vaccination against the toxin undesirable and impractical, leading to intensified efforts to develop effective therapeutics to combat large-scale intoxications. In this review, we examine the relevant and available in vitro cell-based assays and in vivo assays for drug discovery and development, especially with regard to the potential for medium- to high-throughput automation and its use in identifying physiologically relevant inhibitors. C1 [Hakami, Ramin Mollaaghababa] Oak Ridge Associated Univ, Fac Res Participat Program, Belcamp, MD USA. [Hakami, Ramin Mollaaghababa; Ruthel, Gordon; Stahl, Andrea M.; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD USA. [Hakami, Ramin Mollaaghababa] Akimeka Technol LLC, Honolulu, HI USA. RP Hakami, RM (reprint author), Oak Ridge Associated Univ, Fac Res Participat Program, Belcamp, MD USA. EM ramin.hakami@us.army.mil; sina.bavari@us.army.mil FU Defense Threat Reduction Agency [3.10084_09_RD_B] FX We thank Dr James J. Schmidt and Dr Erkan Kiris for their insightful contributions to the manuscript. The views, opinions and/or findings presented here are those of the authors and should not be construed as an official Department of the Army position, policy or decision unless designated by other documentation. This work was supported by a grant from the Defense Threat Reduction Agency (3.10084_09_RD_B to S.B.). NR 67 TC 26 Z9 28 U1 0 U2 7 PU ELSEVIER SCIENCE LONDON PI LONDON PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND SN 0966-842X J9 TRENDS MICROBIOL JI Trends Microbiol. PD APR PY 2010 VL 18 IS 4 BP 164 EP 172 DI 10.1016/j.tim.2010.02.001 PG 9 WC Biochemistry & Molecular Biology; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA 585DH UT WOS:000276804000004 PM 20202845 ER PT J AU Zhang, HF Turner, JA Yang, JS Kosinski, JA AF Zhang, Haifeng Turner, Joseph A. Yang, Jiashi Kosinski, John A. TI Force-frequency effect of thickness mode langasite resonators SO ULTRASONICS LA English DT Article DE Force-frequency effect; Langasite; Resonators ID PERTURBATION-THEORY; QUARTZ; LANGATATE; LANGANITE; SHIFTS AB Langasite resonators are of recent interest for a variety of applications because of their good temperature behavior, good piezoelectric coupling, low acoustic loss and high Q factor. The force-frequency effect describes the shift in resonant frequency a resonator experiences due to the application of a mechanical load. A clear understanding of this effect is essential for many design applications such as pressure sensors. In this article, the frequency shift is analyzed theoretically and numerically for thin, circular langasite plates subjected to a pair of diametrical forces. In addition, the sensitivity of the force-frequency effect is analyzed with respect to the nonlinear material constants. The results are anticipated to be valuable for experimental measurements of nonlinear material constants as well as for device design. (C) 2009 Published by Elsevier B. V. C1 [Zhang, Haifeng; Turner, Joseph A.; Yang, Jiashi] Univ Nebraska, Dept Engn Mech, Lincoln, NE 68588 USA. [Kosinski, John A.] US Army RDECOM CERDEC, ATTN AMSRD CER IW DT, Ft Monmouth, NJ 07703 USA. RP Turner, JA (reprint author), Univ Nebraska, Dept Engn Mech, W317-4 Nebraska Hall, Lincoln, NE 68588 USA. EM jaturner@unl.edu RI Turner, Joseph/F-5165-2010 FU Army Research Office [DAAD19-01-1-0443] FX E. Bigler is gratefully acknowledged for his assistance in providing the experimental data for inclusion in Fig. 15. We would also like to thank Bill Horton and Eric Hague of MtronPTI for their helpful suggestions for this article. [This research was supported by the Army Research Office under Grant No. DAAD19-01-1-0443.] NR 26 TC 6 Z9 6 U1 1 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0041-624X J9 ULTRASONICS JI Ultrasonics PD APR PY 2010 VL 50 IS 4-5 BP 479 EP 490 DI 10.1016/j.ultras.2009.10.008 PG 12 WC Acoustics; Radiology, Nuclear Medicine & Medical Imaging SC Acoustics; Radiology, Nuclear Medicine & Medical Imaging GA 554PI UT WOS:000274446500007 PM 19942246 ER PT J AU Furusato, B Tsunoda, T Shaheduzzaman, S Nau, ME Vahey, M Petrovics, G McLeod, DG Naito, S Shirasawa, S Srivastava, S Sesterhenn, IA AF Furusato, Bungo Tsunoda, Toshiyuki Shaheduzzaman, Syed Nau, Martin E. Vahey, Maryanne Petrovics, Gyorgy McLeod, David G. Naito, Seiji Shirasawa, Senji Srivastava, Shiv Sesterhenn, Isabell A. TI Osteoblast-specific Factor 2 Expression in Prostate Cancer-associated Stroma: Identification Through Microarray Technology SO UROLOGY LA English DT Article ID CELL ADHESION MOLECULE; REACTIVE STROMA; PROGNOSTIC MARKER; TUMOR-STROMA; PERIOSTIN; PROGRESSION; CARCINOMA; MYOFIBROBLASTS; TRANSCRIPTOME; FIBROBLASTS AB OBJECTIVES To better understand the gene expression patterns in tumor-associated stroma, laser-capture-microdissections from clinical specimens were analyzed by genome-wide-expression microarray technology. The epithelial-stromal interaction plays a critical role in prostate development, reactive changes, and tumorigenesis. Diverse microarray technologies have been used to characterize the molecular changes in prostate cancer. Even though these gene expression studies are compromised by the heterogeneity of the tumor, as well as by the difficulty associated with collecting appropriate counterparts to represent normal prostate cells, the gene array data from tumors have shown promising results. Currently, little is known about the tumor-associated stromal gene expression profile in prostate cancer. METHODS Matching benign and malignant epithelial cell-related stroma cells were subjected to microarray platforms. RESULTS The prostatatic stroma expressed several osteogenic molecules. In particular, one of the genes, OSF2, was upregulated in tumor-associated stroma compared with benign epithelial cell associated stroma, which was further validated by immunohistochemical examination. CONCLUSIONS These data show that the combination of laser capture dissection with computational enhancement of epithelial and stromal microarray data is a useful tool to assess gene expression changes in prostate cancer stroma. UROLOGY 75: 768-772, 2010. (C) 2010 Elsevier Inc. C1 Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, US Mil Canc Inst, Bethesda, MD 20814 USA. [Furusato, Bungo] Armed Forces Inst Pathol, Dept Genitourinary Pathol, Washington, DC 20306 USA. Fukuoka Univ, Fac Med, Dept Cell Biol, Jonan Ku, Fukuoka 81401, Japan. Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD USA. Walter Reed Army Med Ctr, Urol Serv, Washington, DC 20307 USA. Kyushu Univ, Grad Sch Med Sci, Dept Urol, Fukuoka 812, Japan. RP Furusato, B (reprint author), Armed Forces Inst Pathol, Dept Genitourinary Pathol, 6825 16 Th St NW, Washington, DC 20306 USA. EM bfurusato@cpdr.org; sesterhe@afip.osd.mil OI Furusato, Bungo/0000-0003-4614-9882 NR 30 TC 3 Z9 4 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 J9 UROLOGY JI Urology PD APR PY 2010 VL 75 IS 4 BP 768 EP 772 DI 10.1016/j.urology.2009.10.026 PG 5 WC Urology & Nephrology SC Urology & Nephrology GA 577XW UT WOS:000276258300003 PM 20035976 ER PT J AU Ozkaya, E Dincer, E Carhan, A Uyar, Y Ertek, M Whitehouse, CA Ozkul, A AF Ozkaya, Etem Dincer, Ender Carhan, Ahmet Uyar, Yavuz Ertek, Mustafa Whitehouse, Chris A. Ozkul, Aykut TI Molecular epidemiology of Crimean-Congo hemorrhagic fever virus in Turkey: Occurrence of local topotype SO VIRUS RESEARCH LA English DT Article DE CCHFV; S-segment; M-segment; Phylogenetic analysis; Turkey; Arboviruses; Bunyaviruses ID NEIGHBOR-JOINING METHOD; GENETIC-ANALYSIS; RNA SEGMENT; RUSSIA; PHYLOGENIES; STRAINS; KOSOVO AB The goal of this study was to investigate the molecular epidemiology of Crimean-Congo hemorrhagic fever virus (CCHFV) in Turkey. The study was performed on a total of 48 confirmed human CCHF cases from 2006 to 2008. The majority of the CCHF viral strains in Turkey were found to belong to the European lineage. Local CCHF viral strains are grouped into two main clusters, which can be further divided into two sub-groups. We also identified an AP92-like virus causing clinical disease in Corum (a mid-Anatolian province). Phylogenetic analysis revealed that the most recent CCHFV infections were caused by intrinsic (or native) CCHF viral strains, which we identified as the local topotype. Comparison of deduced amino acid sequences of S-segment RNAs indicated that the local topotype was derived from viruses of previous years, most likely by a low rate recombination. No genetic differences, based on S- and M-segment RNA sequences, were found between human and tick viral isolates. This data suggest that replication of CCHFV in the tick vector, whether Rhiphicephalus spp. or Hyalomma spp., has no effect on the viral genomic structure. (C) 2010 Elsevier B.V. All rights reserved. C1 [Ozkul, Aykut] Ankara Univ, Fac Vet Med, Dept Virol, TR-06110 Ankara, Turkey. [Ozkaya, Etem; Carhan, Ahmet; Uyar, Yavuz; Ertek, Mustafa] Minist Hlth, RSNPHA, Virol Reference & Res Lab, TR-06100 Ankara, Turkey. [Dincer, Ender] Ankara Univ, Inst Biotechnol, TR-06500 Ankara, Turkey. [Whitehouse, Chris A.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Ozkul, A (reprint author), Ankara Univ, Fac Vet Med, Dept Virol, TR-06110 Ankara, Turkey. EM ozkul@veterinary.ankara.edu.tr RI Dincer, Ender/B-1350-2016; OI Carhan, Ahmet/0000-0003-1584-0072 FU RSNPHA Virology Reference and Research Laboratory FX Authors would like to thank to Directory of Refik Saydam National Public Health Agency (RSNPHA) for providing local CCHF virus isolated and to teh technical staff of RSNPHA Virology Reference and Research Laboratory for their kind support. NR 31 TC 31 Z9 31 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-1702 J9 VIRUS RES JI Virus Res. PD APR PY 2010 VL 149 IS 1 BP 64 EP 70 DI 10.1016/j.virusres.2009.12.014 PG 7 WC Virology SC Virology GA 579BQ UT WOS:000276341900009 PM 20079776 ER PT J AU Shearer, JF AF Shearer, Judy F. TI A Historical Perspective of Pathogen Biological Control of Aquatic Plants SO WEED TECHNOLOGY LA English DT Article DE Aquatic plant management; integrated pest management ID HYACINTH EICHHORNIA-CRASSIPES; WATER-HYACINTH; HYDRILLA-VERTICILLATA; INTEGRATED CONTROL; MYCOLEPTODISCUS-TERRESTRIS; EURASIAN WATERMILFOIL; MYRIOPHYLLUM-SPICATUM; CERCOSPORA-RODMANII; FUSARIUM-CULMORUM; FUNGAL PATHOGEN AB Pathogens were not seriously considered as biological control agents for aquatic plants in the United States until the Chesapeake Bay Eurasian watermilfoil decline occurred in the 1960s. The decline and suggestion that it was induced by pathogens spawned interest in the use of pathogens as biological control agents for nuisance aquatic species. In the years that followed, emphasis was placed on finding pathogen agents for some of the most problematic aquatic weeds, including waterhyacinth, Eurasian watermilfoil, and hydrilla. The scientist that has contributed the most to our knowledge of pathogen biological control in aquatic plants has been Dr. Raghavan Charudattan (University of Florida, Gainesville, FL). For the past 40 yr, he has authored or coauthored more than 50 manuscripts devoted to the subject in peer-reviewed journals, books, and proceedings. C1 USA, Engineer Res & Dev Ctr, Waterways Expt Stn, Vicksburg, MS 39180 USA. RP Shearer, JF (reprint author), USA, Engineer Res & Dev Ctr, Waterways Expt Stn, Vicksburg, MS 39180 USA. EM Judy.F.Shearer@usace.army.mil FU USACE, Engineer Research and Development Center, Environmental Laboratory FX Support for this manuscript came from the USACE, Engineer Research and Development Center, Environmental Laboratory, Aquatic Plant Control Research Program (Vicksburg, MS). Permission was granted by the Chief of Engineers to publish this information. NR 58 TC 2 Z9 2 U1 1 U2 16 PU WEED SCI SOC AMER PI LAWRENCE PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 USA SN 0890-037X J9 WEED TECHNOL JI Weed Technol. PD APR-JUN PY 2010 VL 24 IS 2 BP 202 EP 207 DI 10.1614/WT-D-09-00001.1 PG 6 WC Agronomy; Plant Sciences SC Agriculture; Plant Sciences GA 603JE UT WOS:000278204000022 ER PT J AU Wang, HC Brown, J Alayon, H Stuck, BE AF Wang, Heuy-Ching Brown, Jeremiah Alayon, Helena Stuck, Bruce E. TI Transplantation of quantum dot-labelled bone marrow-derived stem cells into the vitreous of mice with laser-induced retinal injury: Survival, integration and differentiation SO VISION RESEARCH LA English DT Article; Proceedings Paper CT 12th Annual Vision Research Conference on Mechanisms of Macular Degeneration CY MAY 01-02, 2009 CL Lauderdale, FL SP Convent Ctr DE Laser-induced retinal injury; Lineage negative bone marrow cells; Photoreceptor apoptosis; Choroid neovascularization; Retinal pigment epithelium ID ENDOTHELIAL PROGENITOR CELLS; CHOROIDAL NEOVASCULARIZATION; PHOTORECEPTOR SURVIVAL; DIABETIC-RETINOPATHY; PIGMENT EPITHELIUM; VASCULAR REPAIR; STROMAL CELLS; DEGENERATION; MODEL; RESCUE AB Accidental laser exposure to the eyes may result in serious visual impairment due to retina degeneration. Currently limited treatment is available for laser eye injury. In the current study, we investigated the therapeutic potential of bone marrow-derived stem cells (BMSCs) for laser-induced retinal trauma. Lineage negative bone marrow cells (Lin(-) BMCs) were labelled with quantum dots (Qdots) to track the cells in vivo. Lin(-) BMCs survived well after intravitreal injection. In vivo bromodeoxyuridine (BrdU) labelling showed these cells continued to proliferate and integrate into injured retinas. Furthermore, they expressed markers that distinguished retinal pigment epithelium (RPE), endothelium, pericytes and photoreceptors. Our results suggest that BMSCs participate in the repair of retinal lesions by differentiating into retinal cells. Intravitreal transplantation of BMSCs is a potential treatment for laser-induced retinal trauma. Published by Elsevier Ltd. C1 [Wang, Heuy-Ching; Alayon, Helena; Stuck, Bruce E.] USA Med Res Detachment, Walter Reed Army Inst Res, Brooks City Base, TX 78235 USA. [Brown, Jeremiah] Northrop Grumman, San Antonio, TX USA. RP Wang, HC (reprint author), USA Med Res Detachment, Walter Reed Army Inst Res, 7965 Dave Erwin Dr, Brooks City Base, TX 78235 USA. EM Heuy-ching.hetty.wang@us.army.mil NR 40 TC 25 Z9 28 U1 0 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0042-6989 J9 VISION RES JI Vision Res. PD MAR 31 PY 2010 VL 50 IS 7 SI SI BP 665 EP 673 DI 10.1016/j.visres.2009.09.003 PG 9 WC Neurosciences; Ophthalmology SC Neurosciences & Neurology; Ophthalmology GA 574OP UT WOS:000276000600005 PM 19782698 ER PT J AU Samet, ED AF Samet, Elizabeth D. TI Man of Letters Captain Whitten was my student. SO NEW REPUBLIC LA English DT Editorial Material C1 US Mil Acad, West Point, NY 10996 USA. RP Samet, ED (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NEW REPUBLIC INC PI WASHINGTON PA 1331 H STREET, NW STE 700, WASHINGTON, DC 20005 USA SN 0028-6583 J9 NEW REPUBLIC JI New Repub. PD MAR 25 PY 2010 VL 241 IS 4 BP 5 EP 6 PG 2 WC Political Science SC Government & Law GA 568SU UT WOS:000275543800003 ER PT J AU Clements, DE Coller, BAG Lieberman, MM Ogata, S Wang, G Harada, KE Putnak, JR Ivy, JM McDonell, M Bignami, GS Peters, ID Leung, J Weeks-Levy, C Nakano, ET Humphreys, T AF Clements, David E. Coller, Beth-Ann G. Lieberman, Michael M. Ogata, Steven Wang, Gordon Harada, Kent E. Putnak, J. Robert Ivy, John M. McDonell, Michael Bignami, Gary S. Peters, Iain D. Leung, Julia Weeks-Levy, Carolyn Nakano, Eileen T. Humphreys, Tom TI Development of a recombinant tetravalent dengue virus vaccine: Innmunogenicity and efficacy studies in mice and monkeys SO VACCINE LA English DT Article DE Dengue; Envelope; Subunit; Vaccine ID ENVELOPE GLYCOPROTEIN; HEMORRHAGIC-FEVER; NEUTRALIZING ANTIBODIES; MONOCLONAL-ANTIBODIES; STRUCTURAL PROTEINS; DISEASE SEVERITY; STRAIN 16681; CDNA-CLONES; CELLS; DETERMINANTS AB Truncated recombinant dengue virus envelope protein subunits (80E) are efficiently expressed using the Drosophila Schneider-2 (S2) cell expression system. Binding of conformationally sensitive antibodies as well as X-ray crystal structural studies indicate that the recombinant 80E subunits are properly folded native-like proteins. Combining the 80E subunits from each of the four dengue serotypes with ISCOMATRIX (R) adjuvant, an adjuvant selected from a set of adjuvants tested for maximal and long lasting immune responses, results in high titer virus neutralizing antibody responses. Immunization of mice with a mixture of all four 80E subunits and ISCOMATRIX (R) adjuvant resulted in potent virus neutralizing antibody responses to each of the four serotypes. The responses to the components of the tetravalent mixture were equivalent to the responses to each of the subunits administered individually. In an effort to evaluate the potential protective efficacy of the Drosophila expressed 80E, the dengue serotype 2 (DEN280E) subunit was tested in both the mouse and monkey challenge models. In both models protection against viral challenge was achieved with low doses of antigen in the vaccine formulation. In non-human primates, low doses of the tetravalent formulation induced good virus neutralizing antibody titers to all four serotypes and protection against challenge with the two dengue virus serotypes tested. In contrast to previous reports, where subunit vaccine candidates have generally failed to induce potent, protective responses, native-like soluble 80E proteins expressed in the Drosophila S2 cells and administered with appropriate adjuvants are highly immunogenic and capable of eliciting protective responses in both mice and monkeys. These results support the development of a dengue virus tetravalent vaccine based on the four 80E subunits produced in the Drosophila S2 cell expression system. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Clements, David E.; Coller, Beth-Ann G.; Lieberman, Michael M.; Ogata, Steven; Wang, Gordon; Harada, Kent E.; Ivy, John M.; McDonell, Michael; Bignami, Gary S.; Peters, Iain D.; Leung, Julia; Weeks-Levy, Carolyn; Nakano, Eileen T.; Humphreys, Tom] Hawaii Biotech Inc, Aiea, HI 96701 USA. [Putnak, J. Robert] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Coller, BAG (reprint author), Hawaii Biotech Inc, 99-193 Aiea Hts Dr, Aiea, HI 96701 USA. EM coller@hibiotech.com FU Public Health Service [1 R43A135401, 2 R44A135401]; USDA [1890-119]; Department of Defense [DAMD17-93-C-3128] FX The authors thank Dennis Trent formerly at the Food and Drug Administration for providing dengue viral strains and Alan Shatzman at GSK for the Drosophila expression vectors. They also thank Y.S. Hahn for the gift of the plasmid pC8. The authors also thank James Senda, Eric Rohlinger, Beverly Orillo, Timothy Martyak, Michael Thorne, Teri Wong, Milicent Yong, Abu Aslamkhan, Tim Chamberlain, and David Chang for excellent technical assistance. This work was supported by Public Health Service Grants 1 R43A135401 and 2 R44A135401, USDA Contract 1890-119, and a grant from the Department of Defense DAMD17-93-C-3128. NR 65 TC 106 Z9 110 U1 3 U2 19 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD MAR 24 PY 2010 VL 28 IS 15 BP 2705 EP 2715 DI 10.1016/j.vaccine.2010.01.022 PG 11 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 576UK UT WOS:000276174600004 PM 20097152 ER PT J AU Byrd, CM Xiong, ZQ Tsao, CY Bentley, WE AF Byrd, Christopher M. Xiong, Zhiqiang Tsao, Chen-Yu Bentley, William E. TI Understanding mechanistic basis for QS signaling via ChIP-Chip analysis SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA. USA, Res Lab, Sensors & Electon Devices Directorate, Adelphi, MD USA. Univ Maryland, Inst Biotechnol, Ctr Biosyst Res, College Pk, MD 20742 USA. Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 21 PY 2010 VL 239 MA 7-BIOT PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V21DW UT WOS:000208189300685 ER PT J AU Chappell, MA Mao, JD Ford, LS Price, CL AF Chappell, Mark A. Mao, Jing-Dong Ford, Lesley S. Price, Cynthia L. TI Biochars and soil humic surfactancy SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA, Engn Res & Dev Ctr, Vicksburg, MS USA. Old Domin Univ, Dept Chem, Norfolk, VA USA. SpecPro Inc, Huntsville, AL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 21 PY 2010 VL 239 MA 439-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V21DW UT WOS:000208189302383 ER PT J AU Getsinger, KD AF Getsinger, Kurt D. TI Status and future of herbicide use for controlling invasive aquatic plants SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA, Corps Engineers, Dept Engineer Res, Vicksburg, MS 39180 USA. USA, Corps Engineers, Dev Ctr, Vicksburg, MS 39180 USA. NR 0 TC 0 Z9 0 U1 1 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 21 PY 2010 VL 239 MA 44-AGRO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V21DW UT WOS:000208189300228 ER PT J AU Gu, ZF Bauman, RA Long, JB AF Gu, Zengfa Bauman, Richard A. Long, Joseph B. TI Paraoxon causes brain injury and increases the total power of EEG (Electroencephalography) in rats SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Gu, Zengfa; Bauman, Richard A.; Long, Joseph B.] Walter Reed Army Inst Res, Dept Closed Head Injury Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 21 PY 2010 VL 239 MA 299-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V21DW UT WOS:000208189302306 ER PT J AU Hackley, VA MacCuspie, RI Kennedy, AJ AF Hackley, Vincent A. MacCuspie, Robert I. Kennedy, Alan J. TI Barriers to the environmental, health and safety assessment of silver nanoparticles SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 NIST, Mat Sci & Engn Lab, Gaithersburg, MD 20899 USA. USA, Environm Lab, Engn Res & Dev Ctr, Vicksburg, MS USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 21 PY 2010 VL 239 MA 10-IEC PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V21DW UT WOS:000208189302721 ER PT J AU Lambeth, RH Pederson, SJ Rawlett, AM AF Lambeth, Robert H. Pederson, Samuel J. Rawlett, Adam M. TI Analysis and removal of residual catalyst from ROMP based polymers SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Lambeth, Robert H.; Pederson, Samuel J.; Rawlett, Adam M.] USA, Res Lab, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 21 PY 2010 VL 239 MA 320-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V21DW UT WOS:000208189304760 ER PT J AU Orlicki, JA Leadore, JL Strawhecker, KE AF Orlicki, Joshua A. Leadore, Julia L. Strawhecker, Kenneth E. TI Physical property gradients driven by light attenuation during photopolymerization SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Orlicki, Joshua A.; Leadore, Julia L.; Strawhecker, Kenneth E.] USA, Multifunct Mat Branch, Res Lab, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 21 PY 2010 VL 239 MA 475-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V21DW UT WOS:000208189304634 ER PT J AU Riegner, DE Swayze, MD Lachance, ZT AF Riegner, Dawn E. Swayze, Michael D. Lachance, Zachary T. TI Characterization of automated solid phase micro-extraction (SPME) with GC-Toroidal ion trap mass spectrometry for detection of CWA simulants SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Riegner, Dawn E.; Swayze, Michael D.; Lachance, Zachary T.] United States Mil Acad, Dept Chem & Life Sci, West Point, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 21 PY 2010 VL 239 MA 372-CHED PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V21DW UT WOS:000208189301493 ER PT J AU Rinderspacher, BC Andzelm, J Rawlett, A Dougherty, J Lambeth, R AF Rinderspacher, Berend C. Andzelm, Jan Rawlett, Adam Dougherty, Joseph Lambeth, Robert TI Searching chemical space by inverse design SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Rinderspacher, Berend C.; Andzelm, Jan; Rawlett, Adam; Dougherty, Joseph; Lambeth, Robert] USA, Res Lab, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 21 PY 2010 VL 239 MA 58-CINF PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V21DW UT WOS:000208189301783 ER PT J AU Rinderspacher, BC Andzelm, J Rawlett, AM Dougherty, J AF Rinderspacher, Berend Christopher Andzelm, Jan Rawlett, Adam M. Dougherty, Joseph TI Influence of p-bridges in push-pull-chromophores on the transparency-hyperpolarizability tradeoff SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Rinderspacher, Berend Christopher; Andzelm, Jan; Rawlett, Adam M.; Dougherty, Joseph] RDRL WMM A Army Res Lab, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 21 PY 2010 VL 239 MA 136-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V21DW UT WOS:000208189302088 ER PT J AU Guo, JS Hsu, A Chu, D Chen, RR AF Guo, Junsong Hsu, Andrew Chu, Deryn Chen, Rongrong TI Improving Oxygen Reduction Reaction Activities on Carbon-Supported Ag Nanoparticles in Alkaline Solutions SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID MEMBRANE FUEL-CELLS; CATALYSTS; PLATINUM; SILVER; HYDRAZINE; OXIDATION; ELECTROCATALYSTS; ELECTROREDUCTION; ELECTROLYTE; MECHANISM AB Carbon-supported Ag (Ag/C) catalysts with four different metal loadings were prepared by a citrate-protecting method. Oxygen reduction reaction (ORR) activities oil these carbon-supported Ag-nanocatalysts (Ag/C) in alkaline solutions were Studied. Four major findings are reported in this paper: (1) Test results indicate that the Ag/C catalysts promote predominately a four-electron pathway for ORR oil electrodes over the swept potentials from 0.2 to -0.8 V vs Hg/HgO in O(2)-saturated 0.1 M NaOH Solutions. (2) A novel marker for predicting ORR activities on the Ag/C catalysts based oil the cyclic voltammetry characteristic Curves has been identified: the ORR activities have a strong correlation with the intensity of the anodic peak at the potential of 0.230 V vs Hg/HgO in Ar-saturated 0.1 M NaOH Solutions. (3) As the metal loading on carbon particles increases from 10 to 60 wt %, the peak intensities increase linearly, and the ORR onset potentials shift positively with maximum shift of 62 mV for 60% Ag oil carbon Support. (4) A hitherto unnoticed poisoning effect has been discovered: silicate has a significant poisoning effect oil the ORR activities of the Ag/C catalysts. C1 [Guo, Junsong; Hsu, Andrew; Chen, Rongrong] Indiana Univ Purdue Univ, Richard G Lugar Ctr Renewable Energy, Indianapolis, IN 46204 USA. [Chu, Deryn] Army Res Lab, Adelphi, MD 20783 USA. RP Guo, JS (reprint author), Indiana Univ Purdue Univ, Richard G Lugar Ctr Renewable Energy, Indianapolis, IN 46204 USA. FU U.S. Army Research Lab [W911NF-07-2-0036] FX This work was supported by the U.S. Army Research Lab (Grant No. W911NF-07-2-0036). NR 28 TC 143 Z9 146 U1 12 U2 127 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD MAR 18 PY 2010 VL 114 IS 10 BP 4324 EP 4330 DI 10.1021/jp910790u PG 7 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 565XD UT WOS:000275328700011 ER PT J AU Dirlam, PT Strange, GA Orlicki, JA Wetzel, ED Costanzo, PJ AF Dirlam, Philip T. Strange, Gregory A. Orlicki, Joshua A. Wetzel, Eric D. Costanzo, Philip J. TI Controlling Surface Energy and Wetability with Diels-Alder Chemistry SO LANGMUIR LA English DT Article ID 3-DIMENSIONAL MICROVASCULAR NETWORKS; HOLLOW GLASS-FIBERS; MICROFLUIDICS AB Reversible Diels-Alder chemistry was utilized to manipulate the surface energy of glass substrates. Hydrophobic dieneophiles were prepared and attached to glass slides and capillaries to yield a nonwetting surface. Thermal treatment of the surfaces cleaved the Diels-Alder linkage, and resulted in the fabrication of a hydrophilic surface. Preliminary analysis utilized contact angle (CA) Measurements to monitor the change ill Surface energy, and observed a hydrophilic state (CA - 70 +/- 3 degrees) before attachment of the dieneophile to a hydrophobic state (CA - 101 +/- 9 degrees) followed by regeneration of the hydrophilic state (CA - 70 +/- 6 degrees) upon cleavage of the Diels-Alder linkage. The treatments were then applied to glass capillaries, with effective treatment confirmed by fluid column measurements. Patterned treatments were also demonstrated to provide effective flow gating. Finally, attempts to create self-pressurizing capillaries were unsuccessful due to pronounced contact angle hysteresis for the hydrophobic surface treatment. C1 [Dirlam, Philip T.; Strange, Gregory A.; Costanzo, Philip J.] Calif Polytech State Univ San Luis Obispo, Dept Chem & Biochem, San Luis Obispo, CA 93407 USA. [Orlicki, Joshua A.; Wetzel, Eric D.] USA, Res Lab, Div Mat, Aberdeen, MD 21005 USA. RP Costanzo, PJ (reprint author), Calif Polytech State Univ San Luis Obispo, Dept Chem & Biochem, San Luis Obispo, CA 93407 USA. EM pcostanz@calpoly.edu RI Costanzo, Philip/E-8879-2011 OI Costanzo, Philip/0000-0001-6220-463X FU U.S. Army Research Laboratory through the Army Materials Center of Excellence [W911NF-O6-2-0013]; California Polytechnic State University FX Funding and support were provided by the U.S. Army Research Laboratory through the Army Materials Center of Excellence (W911NF-O6-2-0013) program at Drexel University. Additional funding was provided by California Polytechnic State University via start-up funds. Prof. Giuseppe Palinese of Drexel University is acknowledged for stimulating our interest in reversible surface treatments for control of vascular flows. Finally, we would like to acknowledge and thank the Materials Research Facilities Network (MRFN) program at the University of California, Santa Barbara, (NSF-DMR-0520415) for providing instrumentation support used to obtain XPS analysis of samples. NR 25 TC 11 Z9 11 U1 2 U2 13 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD MAR 16 PY 2010 VL 26 IS 6 BP 3942 EP 3948 DI 10.1021/la9032805 PG 7 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 564PE UT WOS:000275226700030 PM 20020732 ER PT J AU Opperman, TJ Williams, JD Houseweart, C Panchal, RG Bavari, S Peet, NP Moir, DT Bowlin, TL AF Opperman, Timothy J. Williams, John D. Houseweart, Chad Panchal, Rekha G. Bavari, Sina Peet, Norton P. Moir, Donald T. Bowlin, Terry L. TI Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR SO BIOORGANIC & MEDICINAL CHEMISTRY LA English DT Article DE Resistance; Bis-indole antibiotics; Efflux; MepR; MepA; Staphylococcus aureus ID MATE FAMILY; REDUCED SUSCEPTIBILITY; MULTIDRUG-RESISTANCE; BACTERIAL GENOMES; PUMP MEPA; BINDING; OVEREXPRESSION; EXPRESSION; PROTEIN; GROOVE AB The bis-indoles are a novel class of compounds with potent antibacterial activity against a broad spectrum of Gram-positive and Gram-negative pathogens. The mechanism of action of these compounds has not been clearly defined. To study the mechanism of action of bis-indoles, selections for mutants of Staphylococcus aureus NCTC 8325 with reduced susceptibility to several chemically related bis-indoles were carried out using serial passages in subinhibitory compound concentrations. Resistant mutants were only obtained for one of the four bis-indoles tested (MBX-1090), and these appeared at concentrations up to 16X MIC within 10-12 passages. MBX-1090 resistance mutations produced a truncated open reading frame of mepR (SAOUHSC_00314), a gene encoding a MarR-like repressor. MepR regulates expression of mepA (SAOUHSC_00315), which encodes a member of the Multidrug and Toxic Compound Extrusion (MATE) family of efflux pumps. MBX-1090 resistance was reverted when mepR (wild type) was provided in trans. Microarray experiments and RT-PCR experiments confirmed that over-expression of mepA is required for resistance. Interestingly, MBX-1090 resistant mutants and strains overexpressing mepA from an expression vector did not exhibit cross-resistance to closely related bis-indole compounds. MBX-1090 did not induce expression of mepA, suggesting that this compound does not directly interact with MepR. Conversely, the bis-indoles that were not substrates of MepA strongly induced mepA expression. The results of this study suggest that MepA and MepR exhibit remarkably distinct substrate specificity for closely related bis-indoles. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Opperman, Timothy J.; Williams, John D.; Houseweart, Chad; Peet, Norton P.; Moir, Donald T.; Bowlin, Terry L.] Microbiotix Inc, Worcester, MA 01605 USA. [Panchal, Rekha G.; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Opperman, TJ (reprint author), Microbiotix Inc, 1 Innovat Dr, Worcester, MA 01605 USA. EM topperman@microbiotix.com OI Williams, John/0000-0001-6609-3842 FU Defense Threat Reduction Agency [HDTRA1-06-C-0042] FX This project has been funded by the following contract from the Defense Threat Reduction Agency: HDTRA1-06-C-0042. The authors would like to thank Bing Li for the calculations describing the predicted physical properties of the bis-indoles. NR 26 TC 10 Z9 11 U1 0 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0968-0896 J9 BIOORGAN MED CHEM JI Bioorg. Med. Chem. PD MAR 15 PY 2010 VL 18 IS 6 BP 2123 EP 2130 DI 10.1016/j.bmc.2010.02.005 PG 8 WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry, Organic SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry GA 568HR UT WOS:000275513700007 PM 20188576 ER PT J AU Mantey, K Kwit, M Nayfeh, MH Kumar, A Stephenson, LD Nelson, AJ AF Mantey, Kevin Kwit, Matthew Nayfeh, M. H. Kumar, Ashok Stephenson, Larry D. Nelson, Andrew J. TI Measurement of the photostability of silicon nanoparticles under UVA and near infrared irradiation SO JOURNAL OF APPLIED PHYSICS LA English DT Article DE disperse systems; dyes; elemental semiconductors; gels; laser materials processing; nanoparticles; photoluminescence; quenching (thermal); silicon; ultraviolet radiation effects ID ULTRASMALL SI NANOPARTICLES; POROUS SILICON; PHOTOLUMINESCENCE; ULTRABRIGHT; SURFACES; FILMS AB We examine the photostability of silicon nanoparticles when they are dispersed in liquid or immobilized in gels or on surfaces. We show that the photoluminescence in static solution develops, under UV irradiation, a long-term stability at the 50% level. Under the same conditions, common dye molecules such as coumarin and stilbene quench with time at rates 8 and 50 fold faster, and exhibit no long-term stability. For the case of immobilized particles in agarose gel as well as on a quartz substrate we used two-photon near infrared femtosecond excitation at 780 nm to induce the blue luminescence. "Parking" the excitation beam, focused on such stationery particles shows that they, unlike similarly immobilized dye molecules, are highly photostable at more than 80%-90% level and do not bleach. The photostability is discussed in terms of excited state interactions and structuring of the silicon outer shell. C1 [Mantey, Kevin; Kwit, Matthew; Nayfeh, M. H.] Univ Illinois, Dept Phys, Urbana, IL 61801 USA. [Kumar, Ashok; Stephenson, Larry D.; Nelson, Andrew J.] ERDC CERL, Champaign, IL 61826 USA. RP Mantey, K (reprint author), Univ Illinois, Dept Phys, 1110 W Green St Urbana, Urbana, IL 61801 USA. EM m-nayfeh@illinois.edu NR 30 TC 3 Z9 3 U1 2 U2 15 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAR 15 PY 2010 VL 107 IS 6 AR 064316 DI 10.1063/1.3326161 PG 5 WC Physics, Applied SC Physics GA 577GP UT WOS:000276210800096 ER PT J AU Eppinger, M Worsham, PL Nikolich, MP Riley, DR Sebastian, Y Mou, S Achtman, M Lindler, LE Ravel, J AF Eppinger, Mark Worsham, Patricia L. Nikolich, Mikeljon P. Riley, David R. Sebastian, Yinong Mou, Sherry Achtman, Mark Lindler, Luther E. Ravel, Jacques TI Genome Sequence of the Deep-Rooted Yersinia pestis Strain Angola Reveals New Insights into the Evolution and Pangenome of the Plague Bacterium SO JOURNAL OF BACTERIOLOGY LA English DT Article ID PLASMINOGEN-ACTIVATOR; PHYLOGENETIC ANALYSIS; PNEUMONIC PLAGUE; PESTOIDES-F; VIRULENCE; BIOVAR; PFRA; PSEUDOTUBERCULOSIS; RESISTANCE; DIVERSITY AB To gain insights into the origin and genome evolution of the plague bacterium Yersinia pestis, we have sequenced the deep-rooted strain Angola, a virulent Pestoides isolate. Its ancient nature makes this atypical isolate of particular importance in understanding the evolution of plague pathogenicity. Its chromosome features a unique genetic make-up intermediate between modern Y. pestis isolates and its evolutionary ancestor, Y. pseudotuberculosis. Our genotypic and phenotypic analyses led us to conclude that Angola belongs to one of the most ancient Y. pestis lineages thus far sequenced. The mobilome carries the first reported chimeric plasmid combining the two species-specific virulence plasmids. Genomic findings were validated in virulence assays demonstrating that its pathogenic potential is distinct from modern Y. pestis isolates. Human infection with this particular isolate would not be diagnosed by the standard clinical tests, as Angola lacks the plasmid-borne capsule, and a possible emergence of this genotype raises major public health concerns. To assess the genomic plasticity in Y. pestis, we investigated the global gene reservoir and estimated the pangenome at 4,844 unique protein-coding genes. As shown by the genomic analysis of this evolutionary key isolate, we found that the genomic plasticity within Y. pestis clearly was not as limited as previously thought, which is strengthened by the detection of the largest number of isolate-specific single-nucleotide polymorphisms (SNPs) currently reported in the species. This study identified numerous novel genetic signatures, some of which seem to be intimately associated with plague virulence. These markers are valuable in the development of a robust typing system critical for forensic, diagnostic, and epidemiological studies. C1 [Eppinger, Mark; Riley, David R.; Ravel, Jacques] Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA. [Eppinger, Mark; Riley, David R.; Ravel, Jacques] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA. [Worsham, Patricia L.; Mou, Sherry] USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. [Nikolich, Mikeljon P.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. [Sebastian, Yinong] J Craig Venter Inst, Rockville, MD 20850 USA. [Achtman, Mark] Univ Coll Cork, ERI, Cork, Ireland. [Lindler, Luther E.] Dept Def Global Emerging Infect Surveillance & Re, Silver Spring, MD 20910 USA. RP Ravel, J (reprint author), Univ Maryland, Sch Med, Inst Genome Sci, 801 W Baltimore St, Baltimore, MD 21201 USA. EM jravel@som.umaryland.edu OI Ravel, Jacques/0000-0002-0851-2233 FU National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services [NIAID N01 AI-30071]; Defense Threat Reduction Agency [1.1A0021_07_RD_B] FX This work was supported with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under NIAID contract N01 AI-30071, and Defense Threat Reduction Agency JSTO-CBD project 1.1A0021_07_RD_B (P. W. L.).; Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U. S. Army.; We thank Richard Borschel for performing the guinea pig assay. Research was conducted in compliance with the Animal Welfare Act and other federal statutes and regulations involving animals and adheres to the principles stated in the Guide for the Care and Use of Laboratory Animals, National Research Council, 1996. The facility where this animal research was conducted is fully accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International. NR 74 TC 39 Z9 644 U1 3 U2 20 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0021-9193 J9 J BACTERIOL JI J. Bacteriol. PD MAR 15 PY 2010 VL 192 IS 6 BP 1685 EP 1699 DI 10.1128/JB.01518-09 PG 15 WC Microbiology SC Microbiology GA 560GW UT WOS:000274891300023 PM 20061468 ER PT J AU Choi, MS Saxena, A Chilukuri, N AF Choi, Moonsuk S. Saxena, Ashima Chilukuri, Nageswararao TI A strategy for the production of soluble human senescence marker protein-30 in Escherichia coli SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS LA English DT Article DE Senescence marker protein-30 (SMP30); Diisopropyl fluorophosphatase (DFPase); Bacterial expression; Molecular chaperones; Solubility; Two-step growth ID RECOMBINANT PROTEINS; TRIGGER FACTOR; DIISOPROPYL PHOSPHOROFLUORIDATE; INCLUSION-BODIES; LIVER; PURIFICATION; AGGREGATION; CHAPERONES; EXPRESSION; PROMOTES AB Senescence marker protein-30 (SMP30) has been reported to hydrolyze diisopropyl fluorophosphate (DFP), a surrogate compound of chemical warfare nerve agents. Thus, SMP30 has the potential to be useful as a prophylactic against chemical warfare nerve agent toxicity. Our efforts to generate human SMP30 in bacteria using a variety of expression vectors invariably resulted in insoluble and inactive preparations. In this study, properly folded and active recombinant human SMP30 (rHuSMP30) was produced in Escherichia coli by coexpressing it with molecular chaperones in a combined strategy. The coexpression of rHuSMP30 with GroES/GroEL/Tf at 15 degrees C, combined with the addition of a membrane fluidizer, increased osmolytes, and a two-step expression resulted in the highest enhancement of solubility and DFPase activity. Our results pave the way for exploring the use of rHuSMP30 against organophosphate and nerve agent toxicity. (C) 2010 Elsevier Inc. All rights reserved. C1 [Choi, Moonsuk S.; Saxena, Ashima] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. [Chilukuri, Nageswararao] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. RP Choi, MS (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM moonsuk.choi@amedd.army.mil FU Defense Threat Reduction Agency [D.0024_07_WR_C]; Department of Defense (DOD) FX This work is supported by a grant from Defense Threat Reduction Agency (DTRA, Project No. D.0024_07_WR_C to Dr. N Chilukuri) from the Department of Defense (DOD). We also thank Dr. Veeraswamy Manne for suggestions with the preparation of the manuscript. NR 23 TC 3 Z9 5 U1 2 U2 3 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0006-291X J9 BIOCHEM BIOPH RES CO JI Biochem. Biophys. Res. Commun. PD MAR 12 PY 2010 VL 393 IS 3 BP 509 EP 513 DI 10.1016/j.bbrc.2010.02.036 PG 5 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 574GW UT WOS:000275978400031 PM 20152811 ER PT J AU Li, B Pai, R Cardinale, SC Butler, MM Peet, NP Moir, DT Bavari, S Bowlin, TL AF Li, Bing Pai, Ramdas Cardinale, Steven C. Butler, Michelle M. Peet, Norton P. Moir, Donald T. Bavari, Sina Bowlin, Terry L. TI Synthesis and Biological Evaluation of Botulinum Neurotoxin A Protease Inhibitors SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID SMALL-MOLECULE INHIBITORS; SEROTYPE-A; LIGHT-CHAIN; IDENTIFICATION; CHEMISTRY; TOXINS; METALLOPROTEASE; RESOLUTION AB NSC 240898 was previously identified as a botulinum neurotoxin A light chain (BoNT/A LC) endopeptidase inhibitor by screening the National Cancer Institute Open Repository diversity set. Two types of analogues have been synthesized and shown to inhibit BoNT/A LC in a FRET-based enzyme assay, with confirmation in an HPLC-based assay. These two series of compounds have also been evaluated for inhibition of anthrax lethal factor (LF), an unrelated metalloprotease, to examine enzyme specificity of the BoNT/A LC inhibition. The most potent inhibitor against BoNT/A LC in these two series is compound 12 (IC(50) = 2.5 mu M, FRET assay), which is 4.4-fold more potent than the lead structure and 11.2-fold more selective for BoNT/A LC versus the anthrax LF metalloproteinase. Structure-activity relationship studies have revealed structural features important to potency and enzyme specificity. C1 [Li, Bing; Pai, Ramdas; Cardinale, Steven C.; Butler, Michelle M.; Peet, Norton P.; Moir, Donald T.; Bowlin, Terry L.] Microbiotix Inc, Worcester, MA 01605 USA. [Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Li, B (reprint author), Microbiotix Inc, 1 Innovat Dr, Worcester, MA 01605 USA. EM bli@microbiotix.com FU National Institutes of Health/National Institute of Allergy and Infectious Diseases [5U01A1070430] FX This work was supported by the National Institutes of Health/National Institute of Allergy and Infectious Diseases (Grant 5U01A1070430). The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services. The authors thank CreaGen Biosciences, Inc. for the preparation of noncommercial starting material 20b and for scale-up synthesis of compounds 9 and 39. NR 32 TC 21 Z9 21 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD MAR 11 PY 2010 VL 53 IS 5 BP 2264 EP 2276 DI 10.1021/jm901852f PG 13 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 562WT UT WOS:000275087000032 PM 20155918 ER PT J AU He, HY Pandey, R Boustani, I Karna, SP AF He, Haiying Pandey, Ravindra Boustani, Ihsan Karna, Shashi P. TI Metal-like Electrical Conductance in Boron Fullerenes SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID VIBRATIONAL PROPERTIES; ELECTRONIC-PROPERTIES; LASER-ABLATION; NANOWIRES; CLUSTERS; TRANSPORT; STABILITY; NANOTUBES; JUNCTIONS; DENSITY AB Electron transport properties of B-fullerenes, B-80 and B-100, are investigated with the use of the first-principles density functional theory (DFT), in conjunction with the Landauer-Buttiker formalism and compared with C-fullerene, C-60, under similar conditions. The differential conductance and the tunnel Current for B-fullerenes sandwiched between Au contacts are calculated to be much higher than those for C-60. An analysis of the calculated density of states and frontier orbitals suggests Such a behavior of B-fullerenes to result from metal-like states, formed from the hybridization of ALL 6s orbital with the highest Occupied molecular orbital of B-fullerenes delocalized over the equator of the icosahedral cages, generally absent in Au-C-60-Au complex. Due to their enhanced electron transport properties, B-fullerenes appear to be attractive candidates for future nanoscale electronics. C1 [He, Haiying; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [He, Haiying; Pandey, Ravindra] Michigan Technol Univ, Multiscale Technol Inst, Houghton, MI 49931 USA. [Boustani, Ihsan] Univ Wuppertal, Fachbereich Theoret Chem C, D-42097 Wuppertal, Germany. [Karna, Shashi P.] USA, Res Lab, Weapons & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA. RP Pandey, R (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. EM pandey@mtu.edu; shashi.karna@us.army.mil FU Army Research Office [W911NF-09-1-0221]; Army Research Laboratory [W911NF-09-2-0026] FX The work at Michigan Technological University was performed under support by Army Research Office through contract number W911NF-09-1-0221 and Army Research Laboratory through contract number W911NF-09-2-0026. NR 50 TC 19 Z9 21 U1 0 U2 18 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD MAR 11 PY 2010 VL 114 IS 9 BP 4149 EP 4152 DI 10.1021/jp9095776 PG 4 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 562JG UT WOS:000275045600063 ER PT J AU Reisler, RB Danner, DK Gibbs, PH AF Reisler, Ronald B. Danner, Denise K. Gibbs, Paul H. TI Immunogenicity of an inactivated Japanese encephalitis vaccine (JE-VAX) in humans over 20 years at USAMRIID: Using PRNT50 as an endpoint for immunogenicity SO VACCINE LA English DT Article DE Japanese encephalitis; Japanese encephalitis vaccine; Plaque-reduction neutralization test (PRNT) ID VIRUS; CONSULTATION; ANTIBODY; SAFETY; GENEVA AB Two hundred and ninety-three subjects received a three-dose primary JE-VAX series and had post-primary shot 3 titers within 56 days at USAMRIID from 1985 to 2005. Overall, the PRNT50 primary response rate (titer of 1:10 or greater) was 269/293 (92%). Eighteen out of 19 subjects (95%) responded with adequate PRNT50 titer within 56 days after first JE-VAX boost. Primary PRNT50 responses to JE-VAX varied significantly in response rates and in geometric means (GMT) by vaccine lot. We recommend that future vaccine studies using PRNT as an immunologic endpoint include a coefficient of variation result alongside the GMT to assist in evaluating GMT results. For subjects who responded within 56 days of primary shot 3, 50% experienced a PRNT50 decline in titer to <1:10 at 805 days and a PRNT80 decline in titer to <1:10 at 355 days. Consequently, for individuals traveling to JE endemic areas, we recommend JE-VAX boost every 2 years and for individuals working with high titers of JE virus in the lab setting, we would recommend JE-VAX boost annually. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Reisler, Ronald B.; Danner, Denise K.; Gibbs, Paul H.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM Ronald.Reisler@amedd.army.mil NR 19 TC 6 Z9 6 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD MAR 11 PY 2010 VL 28 IS 12 BP 2436 EP 2441 DI 10.1016/j.vaccine.2009.12.080 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 576HN UT WOS:000276135200011 PM 20060946 ER PT J AU Heinlen, LD McClain, MT Ritterhouse, LL Bruner, BF Edgerton, CC Keith, MP James, JA Harley, JB AF Heinlen, Latisha D. McClain, Micah T. Ritterhouse, Lauren L. Bruner, Benjamin F. Edgerton, Colin C. Keith, Michael P. James, Judith A. Harley, John B. TI 60 kD Ro and nRNP A Frequently Initiate Human Lupus Autoimmunity SO PLOS ONE LA English DT Article ID ANTI-SM ANTIBODIES; CLINICAL-SIGNIFICANCE; PEPTIDE IMMUNIZATION; HUMORAL AUTOIMMUNITY; SURFACE-STRUCTURES; REVISED CRITERIA; ERYTHEMATOSUS; AUTOANTIBODIES; DIAGNOSIS; NEPHRITIS AB Systemic lupus erythematosus (SLE) is a clinically heterogeneous, humoral autoimmune disorder. The unifying feature among SLE patients is the production of large quantities of autoantibodies. Serum samples from 129 patients collected before the onset of SLE and while in the United States military were evaluated for early pre-clinical serologic events. The first available positive serum sample frequently already contained multiple autoantibody specificities (65%). However, in 34 SLE patients the earliest pre-clinical serum sample positive for any detectable common autoantibody bound only a single autoantigen, most commonly 60 kD Ro (29%), nRNP A (24%), anti-phospholipids (18%) or rheumatoid factor (15%). We identified several recurrent patterns of autoantibody onset using these pre-diagnostic samples. In the serum samples available, anti-nRNP A appeared before or simultaneously with anti-nRNP 70 K in 96% of the patients who had both autoantibodies at diagnosis. Anti-60 kD Ro antibodies appeared before or simultaneously with anti-La (98%) or anti-52 kD Ro (95%). The autoantibody response in SLE patients begins simply, often binding a single specific autoantigen years before disease onset, followed by epitope spreading to additional autoantigenic specificities that are accrued in recurring patterns. C1 [Heinlen, Latisha D.; McClain, Micah T.; Ritterhouse, Lauren L.; Bruner, Benjamin F.; James, Judith A.] Oklahoma Med Res Fdn, Dept Clin Immunol, Oklahoma City, OK 73104 USA. [Heinlen, Latisha D.; Ritterhouse, Lauren L.; James, Judith A.; Harley, John B.] Univ Oklahoma, Hlth Sci Ctr, Dept Internal Med, Oklahoma City, OK USA. [Heinlen, Latisha D.; Ritterhouse, Lauren L.; James, Judith A.; Harley, John B.] Univ Oklahoma, Hlth Sci Ctr, Dept Pathol, Oklahoma City, OK USA. [Edgerton, Colin C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Keith, Michael P.] Natl Naval Med Ctr, Bethesda, MD USA. [Harley, John B.] US Dept Vet Affairs, Oklahoma City, OK USA. [Harley, John B.] Oklahoma Med Res Fdn, Dept Arthrit & Immunol, Oklahoma City, OK 73104 USA. RP Heinlen, LD (reprint author), Oklahoma Med Res Fdn, Dept Clin Immunol, 825 NE 13th St, Oklahoma City, OK 73104 USA. EM harley@omrf.org FU National Institutes of Health [AI31584, AR48045, AR49084, AR45084, AR45451, RR15577, AR48940, RR20143, AI62629, AI50350]; Kirkland Scholar Awards; United States Department of Veterans Affairs; Lou Kerr Chair in Biomedical Research FX This work was supported in part by grants from the National Institutes of Health (AI31584, AR48045, AR49084, AR45084, AR45451, RR15577, AR48940, RR20143, AI62629, AI50350), Kirkland Scholar Awards (JBH and JAJ) and the United States Department of Veterans Affairs. This work was also supported in part by the Lou Kerr Chair in Biomedical Research to JAJ. Bio-Rad provided the ANA test kits and selected the laboratory as a beta-test site for their commercial bead based assay. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 39 TC 22 Z9 22 U1 1 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 10 PY 2010 VL 5 IS 3 AR e9599 DI 10.1371/journal.pone.0009599 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 565XE UT WOS:000275328800012 PM 20224770 ER PT J AU Petrus, P Lisal, M Brennan, JK AF Petrus, Pavel Lisal, Martin Brennan, John K. TI Self-Assembly of Symmetric Diblock Copolymers in Planar Slits with and without Nanopatterns: Insight from Dissipative Particle Dynamics Simulations SO LANGMUIR LA English DT Article ID CHEMICALLY PATTERNED SURFACES; GRAIN-BOUNDARY MORPHOLOGY; BLOCK-COPOLYMERS; THIN-FILMS; ADSORPTION; POLYMER AB We present a dissipative particle dynamics simulation study on the formation of nanostructures of symmetric diblock copolymers confined between planar surfaces with and without nanopatterns. The nanopatterned surface is mimicked by alternating portions of the surface that interact differently with the diblock copolymers. The formation of the diblock-copolymer nanostructures confined between the planar surfaces is investigated and characterized by the separation width and the strength of the interaction between the surfaces and the diblock copolymers. For surfaces with nanopatterns, we also vary both the mutual area and location of the nanopatterns, where we consider nanopatterns oil the opposing surfaces that are vertically (a) aligned, (b) staggered, and (c) partially staggered. In the case of planar slits without nanopatterns, we observe the formation of perpendicular and parallel lamellar phases with different numbers of lamellae. In addition, the symmetric diblock copolymers self-assemble into adsorbed layer and adsorbed layer-parallel lamellar phases and a mixed lamellar phase when the opposing surfaces of the planar slits are modeled by different types of wall beads. In the case of nanopatterned planar slits, we observe novel nanostructures and attempt to rationalize the diblock copolymer self-assembly on the basis of the behavior that we observed in the planar slits without nanopatterns. In particular, we investigate the applicability of predicting the structures formed in the nanopatterned slits by a superposition of the observed structures in slits without nanopatterns. C1 [Petrus, Pavel; Lisal, Martin] ASCR, Inst Chem Proc Fundamentals, E Hala Lab Thermodynam, Vvi, Prague 6, Suchdol, Czech Republic. [Brennan, John K.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM lisal@icpf.cas.cz RI Lisal, Martin/A-8176-2011 OI Lisal, Martin/0000-0001-8005-7143 FU Grant Agency of the Czech Republic [203/08/0094]; National Research Programme "Information Society" [IET400720507]; Academy of Sciences of the Czech Republic "Nanotechnology for Society" [KAN400720701]; European Community [033304]; COST TD0802 FX This research was supported by the Grant Agency of the Czech Republic (grant no. 203/08/0094), by the National Research Programme "Information Society" (project no. IET400720507), by the Grant Programme of the Academy of Sciences of the Czech Republic "Nanotechnology for Society" (project no. KAN400720701), and by the European Community under the sixth Framework Programme (project MULTIPRO no. 033304) and under the seventh Framework Programme (project COST TD0802). NR 34 TC 16 Z9 18 U1 1 U2 22 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD MAR 2 PY 2010 VL 26 IS 5 BP 3695 EP 3709 DI 10.1021/la903200j PG 15 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 556ZP UT WOS:000274636900107 PM 19839566 ER PT J AU Roth, MJ Eamon, CD Slawson, TR Tonyan, TD Dubey, A AF Roth, M. J. Eamon, C. D. Slawson, T. R. Tonyan, T. D. Dubey, A. TI Ultra-High-Strength, Glass Fiber-Reinforced Concrete: Mechanical Behavior and Numerical Modeling SO ACI MATERIALS JOURNAL LA English DT Article DE direct tension test; finite element analysis; flexural test; glass fiber-reinforced concrete; ultra-high-strength concrete ID DIRECT TENSION TEST; UNIAXIAL TENSION; SPECIMENS; TOUGHNESS; TESTS AB The results of a study on the mechanical behavior of a newly developed ultra-high-strength, glass fiber-reinforced concrete (UHS-GFRC) material are presented. Third-point bending experiments, direct tension experiments, and finite element analyses were used to study the material's responses under various loading conditions, and an understanding of the tensile failure characteristics and their relationship to flexural response was developed. Elastic and post first-crack stiffness moduli were determined, as were first-crack strength and a recommended tensile failure function based on the influence of randomly distributed glass reinforcing fibers Finite element analyses using the measured tensile failure function were also used to model flexural response. and comparisons are made to the third-point bending experimental data. C1 [Roth, M. J.] USA, Erdc, Vicksburg, MS USA. [Eamon, C. D.] Lawrence Technol Univ, Dept Civil Engn, Southfield, MI USA. [Slawson, T. R.] Mississippi State Univ, Dept Civil & Environm Engn, Mississippi State, MS USA. [Tonyan, T. D.] US Gypsum Co USG, Syst Dev Struct Technol Grp, Gypsum, CO USA. [Dubey, A.] USG Corp Innovat Ctr, US Gypsum Corp, Libertyville, IL USA. RP Roth, MJ (reprint author), USA, Erdc, Vicksburg, MS USA. NR 32 TC 1 Z9 1 U1 0 U2 6 PU AMER CONCRETE INST PI FARMINGTON HILLS PA 38800 COUNTRY CLUB DR, FARMINGTON HILLS, MI 48331 USA SN 0889-325X J9 ACI MATER J JI ACI Mater. J. PD MAR-APR PY 2010 VL 107 IS 2 BP 185 EP 194 PG 10 WC Construction & Building Technology; Materials Science, Multidisciplinary SC Construction & Building Technology; Materials Science GA 610SP UT WOS:000278756100011 ER PT J AU Gupta, N Cho, K AF Gupta, Nikhil Cho, Kyu TI Blast Protection Materials SO ADVANCED MATERIALS & PROCESSES LA English DT Editorial Material AB A symposium on High Strain Rate Behaviors of Composites and Heterogeneous Materials will be presented at MS&T 2010 in Houston. This is a brief introduction to the topics to be covered. C1 [Gupta, Nikhil] NYU, Polytech Inst, Dept Mech & Aerosp Engn, Brooklyn, NY 11201 USA. [Cho, Kyu] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Gupta, N (reprint author), NYU, Polytech Inst, Dept Mech & Aerosp Engn, Brooklyn, NY 11201 USA. EM ngupta@poly.edu; kcho@arl.army.mil RI Gupta, Nikhil/F-8094-2012 NR 0 TC 1 Z9 1 U1 0 U2 1 PU ASM INT PI MATERIALS PARK PA SUBSCRIPTIONS SPECIALIST CUSTOMER SERVICE, MATERIALS PARK, OH 44073-0002 USA SN 0882-7958 J9 ADV MATER PROCESS JI Adv. Mater. Process. PD MAR PY 2010 VL 168 IS 3 BP 32 EP 33 PG 2 WC Materials Science, Multidisciplinary SC Materials Science GA 568XV UT WOS:000275560400006 ER PT J AU Patel, SH Bakeev, KA Chen, G Zhang, Q Wan, C AF Patel, S. H. Bakeev, Katherine A. Chen, Gary Zhang, Qi Wan, Chen TI Determination of %Polyvinyl Alcohol in Vinyl Acetate-Alcohol Resins by Quantitative Near Infrared Spectroscopic Analysis SO ADVANCES IN POLYMER TECHNOLOGY LA English DT Article DE Copolymer composition; Hydrolysis of VAAR; Hydroxyl content of polymers; Near infrared spectroscopy ID LEAST-SQUARES REGRESSION; REFLECTANCE SPECTROSCOPY; MULTIVARIATE CALIBRATION; NIR SPECTROSCOPY; HYDROXYL VALUE; POLYESTER; POLYMERS; NUMBER AB A number of vinyl acetate-alcohol resins (VAAR) samples were collected during partial hydrolysis of poly(vinyl acetate) at different conversions levels (<30%). Using these VAAR samples with known OH (hydroxyl) content, it has been demonstrated that near infrared (NIR) spectroscopic data produced a near perfect fit for the calibration of OH content. A 4-factor partial least-squares method was employed and gave the best results. Further work also confirmed that NIR, operating at a well-controlled environment, is able to quantify, with great precision, the OH content of the selected model compound. In the case for the OH content analysis of VAAR resins, solvent mix ratio (methyl acetate: methanol) and temperature have been identified to be the two most influential factors on the analytical results. (C) 2010 Wiley Periodicals, Inc. Ads' Polym Techn 29: 1-10, 2010; Published online in Wiley Inter Science (www.interscience.wiley.com). DOI 10.1002/adv.20166 C1 [Patel, S. H.; Zhang, Qi] Inst Polymer Proc, Newark, NJ 07102 USA. [Bakeev, Katherine A.] CAMO Software Inc, Woodbridge, NJ 07095 USA. [Chen, Gary] USA, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. [Wan, Chen] SABIC Innovat Plast, Washington, WV 26181 USA. RP Patel, SH (reprint author), Inst Polymer Proc, Newark, NJ 07102 USA. EM subhash@polymers-ppi.org FU U.S. Army Armament Research, Development and Engineering Center, Picatinny, NJ FX Contract grant sponsor: U.S. Army Armament Research, Development and Engineering Center, Picatinny, NJ. NR 21 TC 3 Z9 3 U1 1 U2 12 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0730-6679 J9 ADV POLYM TECH JI Adv. Polym. Technol. PD SPR PY 2010 VL 29 IS 1 BP 1 EP 10 DI 10.1002/adv.20166 PG 10 WC Engineering, Chemical; Polymer Science SC Engineering; Polymer Science GA 598AZ UT WOS:000277805600001 ER PT J AU Abbott, KC Yuan, CM AF Abbott, Kevin C. Yuan, Cristina M. TI The Map Is Not the Territory-Mapping Out the Course and Cost of CKD SO AMERICAN JOURNAL OF KIDNEY DISEASES LA English DT Editorial Material C1 [Abbott, Kevin C.] Walter Reed Army Med Ctr, Dialysis & Nephrol Serv, Washington, DC 20307 USA. RP Abbott, KC (reprint author), Walter Reed Army Med Ctr, Dialysis & Nephrol Serv, 6900 Georgia Ave, Washington, DC 20307 USA. EM kevin.abbott@us.army.mil OI Abbott, Kevin/0000-0003-2111-7112 NR 11 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0272-6386 J9 AM J KIDNEY DIS JI Am. J. Kidney Dis. PD MAR PY 2010 VL 55 IS 3 BP 419 EP 422 DI 10.1053/j.ajkd.2010.01.003 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA 563DW UT WOS:000275109000005 PM 20189049 ER PT J AU Broy, C AF Broy, Charles TI Computer Calls for Cardiology Consult STAT! SO AMERICAN JOURNAL OF MEDICINE LA English DT Editorial Material ID INTRAVENTRICULAR-CONDUCTION DISTURBANCES; EARLY REPOLARIZATION; ACUTE PERICARDITIS; ELECTROCARDIOGRAM; CRITERIA C1 [Broy, Charles] USA, Infantry Div 4, Washington, DC USA. RP Broy, C (reprint author), 1501 Cedar Springs Circle, Clarksville, TN 37042 USA. EM broychar@yahoo.com NR 6 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9343 J9 AM J MED JI Am. J. Med. PD MAR PY 2010 VL 123 IS 3 BP 225 EP 227 DI 10.1016/j.amjmed.2009.11.007 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 572EE UT WOS:000275809400010 PM 20193829 ER PT J AU Bochicchio, GV Kilbourne, MJ Keledjian, K Hess, J Scalea, T AF Bochicchio, Grant V. Kilbourne, Michael J. Keledjian, Kaspar Hess, John Scalea, Thomas TI Evaluation of a New Hemostatic Agent in a Porcine Grade V Liver Injury Model SO AMERICAN SURGEON LA English DT Article ID FIBRIN SEALANT DRESSINGS; HYPOTHERMIC COAGULOPATHIC SWINE; REDUCE BLOOD-LOSS; RESUSCITATION VOLUME; PERIHEPATIC PACKING; IMPROVE SURVIVAL; HEMORRHAGE; TRAUMA; EFFICACY AB Our objective was to evaluate the hemostatic efficacy of a newly modified chitosan in a porcine grade V liver injury model. Fifteen Yorkshire pigs underwent standardized grade V liver injuries with a specially designed liver clamp and were randomized to either modified chitosan (MC) patch treatment or standard gauze packing. Free bleeding was allowed for 30 seconds. Fluid resuscitation was infused as necessary to reestablish a mean arterial pressure (MAP) within at least 80 percent of the preinjury MAR Animals were observed for 90 minutes or until death. Endpoints were survival, total blood loss, time to hemostasis, and resuscitation MAP, and resuscitation volume. Total mean blood loss was less in the MC patch group (464 +/- 267 mL vs 1234 +/- 78 mL, P < 0.001). Time to hemostasis was significantly less (4.8 +/- 2.5 minutes in the MC patch group VS 9.6 +/- 2.5 minutes, P < 0.01). Fluid resuscitation was less (1098 459 mL in the MC patch group vs 1.770 +/- 172 mL, 13 < 0.01). Survival was 100 per cent in the MC patch group and 80 per cent in the gauze packing group. MC patches demonstrate the continued hemostatic agent evolution for improved control of lethal solid organ bleeding. C1 [Bochicchio, Grant V.; Keledjian, Kaspar; Scalea, Thomas] R Adams Cowley Shock Trauma Ctr, Div Clin & Outcomes Res, Dept Surg, Baltimore, MD 21201 USA. [Kilbourne, Michael J.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Hess, John] Univ Maryland, Dept Pathol, Baltimore, MD 21201 USA. RP Bochicchio, GV (reprint author), R Adams Cowley Shock Trauma Ctr, Div Clin & Outcomes Res, Dept Surg, 22 S Greene St,T1R60, Baltimore, MD 21201 USA. NR 19 TC 5 Z9 5 U1 0 U2 1 PU SOUTHEASTERN SURGICAL CONGRESS PI ATLANTA PA 141 WEST WIEUCA RD, STE B100, ATLANTA, GA 30342 USA SN 0003-1348 J9 AM SURGEON JI Am. Surg. PD MAR PY 2010 VL 76 IS 3 BP 317 EP 320 PG 4 WC Surgery SC Surgery GA 560VT UT WOS:000274932700015 PM 20349664 ER PT J AU Kosisky, SE Marks, MS Nelson, MR AF Kosisky, Susan E. Marks, Mariko S. Nelson, Michael R. TI Pollen aeroallergens in the Washington, DC, metropolitan area: a 10-year volumetric survey (1998-2007) SO ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY LA English DT Article ID AMBROSIA-ARTEMISIIFOLIA L.; AIRBORNE POLLEN; ALLERGIC RHINITIS; NEW-JERSEY; CALIFORNIA; COUNTS; CITY; EPIDEMIOLOGY; ASTHMA; FUNGI AB Background: Local aeroallergen surveys identify and establish patterns of prevalence for tree, grass, and weed species that enable the clinician to more effectively select allergens for skin testing and therapy. Objectives: To determine peak pollination periods, atmospheric concentrations, and year-to-year variation for identified tree, weed, and grass aeroallergens and examine the influence of selected meteorological parameters. Methods: Atmospheric sampling for pollen aeroallergens was performed using a volumetric rotating-arm impaction sampler. The Spearman correlation coefficient was used to determine the relationship between daily counts and selected meteorological parameters. Results: Previous findings for area trees, conducted at a different location, are corroborated. Predominant pollen types include Quercus, Cupressaceae, Pinaceae, Morus, Betulaceae, Acer, Platanus, Fraxinus, Poaceae, and Ambrosia. Early flowering weeds (Rumex and Typha) and Poaceae overlap with peak tree season in April. Biphasic seasons are noted for Poaceae and Ulmus. Tree pollen accounts for 91.2%, weeds 3.8%, and grasses 3.2% of total annual pollen yield. Variation in overall pollen production is evident from year to year. High production years for some species are low for others. Cyclic pollinating patterns for Alnus, Betulaceae, and Fagus were observed. Grass and weed pollen correlated positively with maximum temperature and dew point; however, the results for individual tree species were variable. Conclusion: The Washington, DC, metropolitan area is host to a variety of tree, weed, and grass species that produce copious amounts of pollen. Further investigation into year-to-year variation with respect to inherent cycling and meteorological influences is warranted. Ann Allergy Asthma Immunol. 2010; 104:223-235. C1 [Kosisky, Susan E.; Marks, Mariko S.; Nelson, Michael R.] Walter Reed Army Med Ctr, Dept Allergy & Immunol, Washington, DC 20307 USA. RP Kosisky, SE (reprint author), USA, Centralized Allergen Extract Lab, Bldg 512,Forest Glen Annex,9100 Brookeville Rd, Silver Spring, MD 20910 USA. EM Susan.Kosisky@amedd.army.mil NR 50 TC 17 Z9 18 U1 0 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1081-1206 J9 ANN ALLERG ASTHMA IM JI Ann. Allergy Asthma Immunol. PD MAR PY 2010 VL 104 IS 3 BP 223 EP 235 DI 10.1016/j.anai.2010.01.005 PG 13 WC Allergy; Immunology SC Allergy; Immunology GA 701OI UT WOS:000285828900007 PM 20377112 ER PT J AU Heine, HS Purcell, BK Bassett, J Miller, L Goldstein, BP AF Heine, Henry S. Purcell, Bret K. Bassett, Jennifer Miller, Lynda Goldstein, Beth P. TI Activity of Dalbavancin against Bacillus anthracis In Vitro and in a Mouse Inhalation Anthrax Model SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID AEROSOL CHALLENGE MODEL; STAPHYLOCOCCUS-AUREUS; POSTEXPOSURE PROPHYLAXIS; BACTERICIDAL ACTIVITY; INFECTION MODEL; PHARMACOKINETICS; GLYCOPEPTIDE; EFFICACY; RESISTANCE; SPECTRUM AB Bacillus anthracis, the causative agent of anthrax, can produce fatal disease when it is inhaled or ingested by humans. Dalbavancin, a novel, semisynthetic lipoglycopeptide, has potent activity, greater than that of vancomycin, against Gram-positive bacteria and a half-life in humans that supports once-weekly dosing. Dalbavancin demonstrated potent in vitro activity against B. anthracis (MIC range, <= 0.03 to 0.5 mg/liter; MIC(50) and MIC(90), 0.06 and 0.25 mg/liter, respectively), which led us to test its efficacy in a murine inhalation anthrax model. The peak concentrations of dalbavancin in mouse plasma after the administration of single intraperitoneal doses of 5 and 20 mg/kg of body weight were 15 and 71 mg/kg, respectively. At 20 mg/kg, the dalbavancin activity was detectable for 6 days after administration (terminal half-life, 53 h), indicating that long intervals between doses were feasible. The mice were challenged with 50 to 100 times the median lethal dose of the Ames strain of B. anthracis, an inoculum that kills untreated animals within 4 days. The efficacy of dalbavancin was 80 to 100%, as determined by the rate of survival at 42 days, when treatment was initiated 24 h postchallenge with regimens of 15 to 120 mg/kg every 36 h (q36h) or 30 to 240 mg/kg every 72 h (q72h). A regimen of ciprofloxacin known to protect 100% of animals was tested in parallel. Delayed dalbavancin treatment (beginning 36 or 48 h postchallenge) with 60 mg/kg q36h or 120 mg/kg q72h still provided 70 to 100% survival. The low MICs and long duration of efficacy in vivo suggest that dalbavancin may have potential as an alternative treatment or for the prophylaxis of B. anthracis infections. C1 [Heine, Henry S.; Purcell, Bret K.; Bassett, Jennifer; Miller, Lynda] USA, Med Res Inst Infect Dis, Frederick, MD USA. [Goldstein, Beth P.] Vicuron Pharmaceut, New York, NY USA. RP Heine, HS (reprint author), Div Bacteriol, 1425 Porter St, Ft Detrick, MD 21702 USA. EM henry.heine@amedd.army.mil FU Defense Threat Reduction Agency [02-4-2C-013]; Pfizer Inc. FX The research described herein was sponsored by the Defense Threat Reduction Agency (project no. 02-4-2C-013). B. P. G. was an employee of Vicuron Inc., which was acquired by Pfizer Inc. after completion of this study. B. P. G. received an honorarium from Pfizer Inc. in connection with the development of the manuscript.; The opinions, interpretations, conclusions, and recommendations presented here are those of the authors and are not necessarily endorsed by the U. S. Army. Downloaded from aac. asm. org by Institute Thomson Reuters on February 23, 2010 NR 46 TC 8 Z9 10 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD MAR PY 2010 VL 54 IS 3 BP 991 EP 996 DI 10.1128/AAC.00820-09 PG 6 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 558HY UT WOS:000274733300004 PM 20047912 ER PT J AU Elkins, CA Mullis, LB Lacher, DW Jung, CM AF Elkins, Christopher A. Mullis, Lisa B. Lacher, David W. Jung, Carina M. TI Single Nucleotide Polymorphism Analysis of the Major Tripartite Multidrug Efflux Pump of Escherichia coli: Functional Conservation in Disparate Animal Reservoirs despite Exposure to Antimicrobial Chemotherapy SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID ENTERICA SEROVAR TYPHIMURIUM; LARGE PERIPLASMIC LOOPS; SUBSTRATE-SPECIFICITY; PHYLOGENETIC NETWORKS; MEMBRANE PROTEINS; RESISTANCE; SALMONELLA; MUTATIONS; RECOMBINATION; TETRACYCLINE AB AcrAB-TolC imparts a strong intrinsic resistance phenotype to many clinically significant molecules in Escherichia coli. This complex is composed of a pump, AcrB, and a periplasmic protein, AcrA, that exports substrates through a common outer membrane porin, TolC. A sequence survey of the pump-specific components, acrA and acrB, was conducted on three discrete animal reservoirs: rodents, bovines, and catfish. Although two of the reservoirs (bovine and catfish) were agrarian, and antibiotic use (ceftiofur and oxytetracycline/Romet 30, respectively) was reported for them, the vast majority of structural polymorphisms were silent except for T104A (AcrA) and Q733R (AcrB), found in certain bovine-derived strains. Overall, the genes were well conserved, with high ratios of synonymous to nonsynonymous substitutions (d(S)/d(N) ratios), consistent with or, in the case of acrB, better than those of standard multilocus sequence typing (MLST) loci. Furthermore, predicted recombination points from single nucleotide polymorphism (SNP) patterns in acrB support a modular evolution of transporter proteins, consistent with an ancient origin. However, functional studies with clones representing the major silent SNPs and the nonsilent mutation in acrB failed to generate significant differences in resistance to a range of common efflux pump substrates. Interestingly, a comparison between log-phase acrA and acrB expression profiles yielded inconsistent trends, with acrB expression increasing modestly (<1.8-fold) in many strains from the antibiotic-enriched pools. Our results suggest that structural polymorphisms in this major efflux pump system may not contribute significantly to adaptive resistance by altering function or substrate specificity but may have a potential use in improving phylogenetic relationships and/or source tracking. C1 [Elkins, Christopher A.; Lacher, David W.] US FDA, Div Mol Biol, Ctr Food Safety & Appl Nutr, Laurel, MD 20708 USA. [Elkins, Christopher A.; Mullis, Lisa B.; Jung, Carina M.] US FDA, Div Microbiol, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA. [Jung, Carina M.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Elkins, CA (reprint author), US FDA, Div Mol Biol, Ctr Food Safety & Appl Nutr, 8301 Muirkirk Rd, Laurel, MD 20708 USA. EM chris.elkins@fda.hhs.gov NR 35 TC 6 Z9 6 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD MAR PY 2010 VL 54 IS 3 BP 1007 EP 1015 DI 10.1128/AAC.01126-09 PG 9 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 558HY UT WOS:000274733300006 PM 20038628 ER PT J AU Krakauer, T Buckley, M Issaq, HJ Fox, SD AF Krakauer, Teresa Buckley, Marilyn Issaq, Haleem J. Fox, Stephen D. TI Rapamycin Protects Mice from Staphylococcal Enterotoxin B-Induced Toxic Shock and Blocks Cytokine Release In Vitro and In Vivo SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID REGULATORY T-CELLS; CLASS-II MOLECULES; MAMMALIAN TARGET; LETHAL SHOCK; BACTERIAL SUPERANTIGENS; THERAPEUTIC TARGET; DENDRITIC CELLS; TRANSGENIC MICE; HUMAN-DISEASE; ACTIVATION AB Staphylococcal enterotoxins are potent activators for human T cells and cause lethal toxic shock. Rapamycin, an immunosuppressant, was tested for its ability to inhibit staphylococcal enterotoxin B (SEB)-induced activation of human peripheral blood mononuclear cells (PBMC) in vitro and toxin-mediated shock in mice. Stimulation of PMBC by SEB was effectively blocked by rapamycin as evidenced by the inhibition of tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1 beta), IL-6, IL-2, gamma interferon (IFN-gamma), monocyte chemoattractant protein 1 (MCP-1), macrophage inflammatory protein 1 alpha (MIP-1 alpha), MIP-1 beta, and T-cell proliferation. In vivo, rapamycin protected 100% of mice from lethal shock, even when administered 24 h after intranasal SEB challenge. The serum levels of MCP-1 and IL-6, after intranasal exposure to SEB, were significantly reduced in mice given rapamycin versus controls. Additionally, rapamycin diminished the weight loss and temperature fluctuations elicited by SEB. C1 [Krakauer, Teresa; Buckley, Marilyn] USA, Med Res Inst Infect Dis, Dept Immunol, Integrated Toxicol Div, Frederick, MD 21702 USA. [Issaq, Haleem J.; Fox, Stephen D.] Sci Applicat Int Corp Frederick Inc, Lab Prote & Analyt Technol, Frederick, MD 21702 USA. RP Krakauer, T (reprint author), USA, Med Res Inst Infect Dis, Dept Immunol, Integrated Toxicol Div, Bldg 1425, Frederick, MD 21702 USA. EM teresa.krakauer@amedd.army.mil FU Defense Threat Reduction Agency FX The views expressed in this publication are those of the author and do not reflect the official policy or position of the Department of the Army, the Department of Defense, or the U. S. Government.; The source of support was the Defense Threat Reduction Agency. NR 56 TC 26 Z9 30 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD MAR PY 2010 VL 54 IS 3 BP 1125 EP 1131 DI 10.1128/AAC.01015-09 PG 7 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 558HY UT WOS:000274733300021 PM 20086156 ER PT J AU Whitehouse, CA Baldwin, C Sampath, R Blyn, LB Melton, R Li, F Hall, TA Harpin, V Matthews, H Tediashvili, M Jaiani, E Kokashvili, T Janelidze, N Grim, C Colwell, RR Huq, A AF Whitehouse, Chris A. Baldwin, Carson Sampath, Rangarajan Blyn, Lawrence B. Melton, Rachael Li, Feng Hall, Thomas A. Harpin, Vanessa Matthews, Heather Tediashvili, Marina Jaiani, Ekaterina Kokashvili, Tamar Janelidze, Nino Grim, Christopher Colwell, Rita R. Huq, Anwar TI Identification of Pathogenic Vibrio Species by Multilocus PCR-Electrospray Ionization Mass Spectrometry and Its Application to Aquatic Environments of the Former Soviet Republic of Georgia SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID CHOLERAE AB The Ibis T5000 is a novel diagnostic platform that couples PCR and mass spectrometry. In this study, we developed an assay that can identify all known pathogenic Vibrio species and field-tested it using natural water samples from both freshwater lakes and the Georgian coastal zone of the Black Sea. Of the 278 total water samples screened, 9 different Vibrio species were detected, 114 (41%) samples were positive for V. cholerae, and 5 (0.8%) samples were positive for the cholera toxin A gene (ctxA). All ctxA-positive samples were from two freshwater lakes, and no ctxA-positive samples from any of the Black Sea sites were detected. C1 [Whitehouse, Chris A.] USA, Med Res Inst Infect Dis, Diagnost Syst Div, Frederick, MD 21702 USA. [Sampath, Rangarajan; Blyn, Lawrence B.; Melton, Rachael; Li, Feng; Hall, Thomas A.; Harpin, Vanessa; Matthews, Heather] Ibis Biosci, Carlsbad, CA USA. [Tediashvili, Marina; Jaiani, Ekaterina; Kokashvili, Tamar; Janelidze, Nino] G Eliava Inst Bacteriophage Microbiol & Virol, Tbilisi, Rep of Georgia. [Grim, Christopher; Colwell, Rita R.; Huq, Anwar] Univ Maryland, Maryland Pathogen Res Inst, College Pk, MD 20742 USA. [Colwell, Rita R.] Univ Maryland, Ctr Bioinformat & Computat Biol, College Pk, MD 20742 USA. RP Whitehouse, CA (reprint author), USA, Med Res Inst Infect Dis, Diagnost Syst Div, 1425 Porter St, Frederick, MD 21702 USA. EM chris.whitehouse@us.army.mil FU U.S. Defense Threat Reduction Agency (DTRA) [GG-13]; IC [HM15820612010] FX This research was supported, in part, by the U.S. Defense Threat Reduction Agency (DTRA) Cooperative Threat Reduction Program (project GG-13). C. Grim was supported by an IC Postdoctoral Research Fellowship (NGA grant HM15820612010). NR 10 TC 9 Z9 9 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD MAR PY 2010 VL 76 IS 6 BP 1996 EP 2001 DI 10.1128/AEM.01919-09 PG 6 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 564DQ UT WOS:000275193900033 PM 20118359 ER PT J AU Blue, MA Ntuen, C Letowski, T AF Blue, Misty A. Ntuen, Celestine Letowski, Tomasz TI Speech intelligibility measured with shortened versions of Callsign Acquisition Test (CAT) SO APPLIED ERGONOMICS LA English DT Article DE Callsign Acquisition Test (CAT); Speech intelligibility testing; Predictive power ID WORD RECOGNITION AB The Callsign Acquisition Test (CAT) is a new speech intelligibility test developed by the Human Research and Engineering Directorate of the U.S. Army Research Laboratory (ARL-HRED). CAT uses the phonetic alphabet and digit stimuli combined together to form 126 test items. Objective: The purpose of this study was to assess the reliability of data collected with shorter versions of CAT. Design: A total of 5 shorter versions of the original list (CAT-120, CAT-60, CAT-40, CAT-30, and CAT-24) were formed and evaluated using 19 participants. Each of the subsets of CAT was presented in pink noise at signal-to-noise ratios (SNRs) of -6 dB and -9 dB. Results: Results showed that shortened CAT lists have the capability of providing the same predictive power as the full CAT with good test-retest reliability. Conclusions: Under the experimental conditions of this study, any of the shorter versions of the CAT can be utilized in place of the full version to reduce testing times with no effect on predictive power. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Blue, Misty A.] Wright State Univ, Dept Biomed Ind & Human Factors Engn, Dayton, OH 45435 USA. [Ntuen, Celestine] N Carolina Agr & Tech State Univ, Dept Ind & Syst Engn, Greensboro, NC 27411 USA. [Letowski, Tomasz] USA, Res Lab, Human Res & Engn Directorate, Aberdeen, MD USA. RP Blue, MA (reprint author), Wright State Univ, Dept Biomed Ind & Human Factors Engn, 240 Russ Engn Ctr,3640 Colonel Glenn Highway, Dayton, OH 45435 USA. EM misty.blue@wright.edu FU United States Army Research Laboratory - Human Research and Engineering Directorate in Aberdeen Proving Grounds, Maryland FX This work was funded by the United States Army Research Laboratory - Human Research and Engineering Directorate in Aberdeen Proving Grounds, Maryland. NR 14 TC 3 Z9 3 U1 1 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0003-6870 J9 APPL ERGON JI Appl. Ergon. PD MAR PY 2010 VL 41 IS 2 BP 291 EP 294 DI 10.1016/j.apergo.2009.07.011 PG 4 WC Engineering, Industrial; Ergonomics; Psychology, Applied SC Engineering; Psychology GA 527YD UT WOS:000272406300014 PM 19748610 ER PT J AU Maloney, PG Smith, P King, V Billman, C Winkler, M Mazur, E AF Maloney, Patrick G. Smith, Peter King, Vernon Billman, Curtis Winkler, Mark Mazur, Eric TI Emissivity of microstructured silicon SO APPLIED OPTICS LA English DT Article ID FEMTOSECOND-LASER-PULSES AB Infrared transmittance and hemispherical-directional reflectance data from 2.5 to 25 mu m on microstructured silicon surfaces have been measured, and spectral emissivity has been calculated for this wavelength range. Hemispherical-total emissivity is calculated for the samples and found to be 0.84 before a measurement-induced annealing and 0.65 after the measurement for the sulfur-doped sample. Secondary samples lack a measurement-induced anneal, and reasons for this discrepancy are presented. Emissivity numbers are plotted and compared with a silicon substrate, and Aeroglaze Z306 black paint. Use of microstructured silicon as a blackbody or microbolometer surface is modeled and presented, respectively. (C) 2010 Optical Society of America C1 [Maloney, Patrick G.; Smith, Peter; King, Vernon; Billman, Curtis] USA, Commun Elect Res Dev & Engn Ctr, Night Vis & Elect Sensors Directorate, Res Dev & Engn Command,Sci & Technol Div, Ft Belvoir, VA 22060 USA. [Winkler, Mark; Mazur, Eric] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA. RP Maloney, PG (reprint author), USA, Commun Elect Res Dev & Engn Ctr, Night Vis & Elect Sensors Directorate, Res Dev & Engn Command,Sci & Technol Div, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. EM info@nvl.army.mil NR 10 TC 17 Z9 17 U1 0 U2 19 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD MAR 1 PY 2010 VL 49 IS 7 BP 1065 EP 1068 DI 10.1364/AO.49.001065 PG 4 WC Optics SC Optics GA 566RF UT WOS:000275390000008 PM 20197803 ER PT J AU Liu, L Dharne, M Kannan, P Smith, A Meng, JH Fan, MT Boren, TL Ranallo, RT Bhagwat, AA AF Liu, Liu Dharne, Mahesh Kannan, Porteen Smith, Allen Meng, Jianghong Fan, Mingtao Boren, Tara L. Ranallo, Ryan T. Bhagwat, Arvind A. TI Osmoregulated periplasmic glucans synthesis gene family of Shigella flexneri SO ARCHIVES OF MICROBIOLOGY LA English DT Article DE Periplasmic glucans; Low osmolarity; Food- and water-borne Shigellosis ID ENTERICA SEROVAR TYPHIMURIUM; ESCHERICHIA-COLI; BIOSYNTHESIS; OLIGOSACCHARIDES; RESISTANCE; PROTEIN; MICE AB Osmoregulated periplasmic glucans (OPGs) of food- and water-borne enteropathogen Shigella flexneri were characterized. OPGs were composed of 100% glucose with 2-linked glucose as the most abundant residue with terminal glucose, 2-linked and 2,6-linked glucose also present in high quantities. Most dominant backbone polymer chain length was seven glucose residues. Individual genes from the opg gene family comprising of a bicistronic operon opgGH, opgB, opgC and opgD were mutagenized to study their effect on OPGs synthesis, growth in hypo-osmotic media and ability to invade HeLa cells. Mutation in opgG and opgH abolished OPGs biosynthesis, and mutants experienced longer lag time to initiate growth in hypo-osmotic media. Longer lag times to initiate growth in hypo-osmotic media were also observed for opgC and opgD mutants but not for opgB mutant. All opg mutants were able to infect HeLa cells, and abolition of OPGs synthesis did not affect actin polymerization or plaque formation. Ability to synthesize OPGs was beneficial to bacteria in order to initiate growth under low osmolarity conditions, in vitro mammalian cell invasion assays, however, could not discriminate whether OPGs were required for basic aspect of Shigella virulence. C1 [Liu, Liu; Dharne, Mahesh; Kannan, Porteen; Bhagwat, Arvind A.] ARS, Environm Microbial & Food Safety Lab, Henry A Wallace Beltsville Agr Res Ctr, USDA, Beltsville, MD 20705 USA. [Liu, Liu; Fan, Mingtao] NW A&F Univ, Coll Food Sci & Technol, Yangling 712100, Peoples R China. [Smith, Allen] ARS, Diet Genom & Immunol Lab, Henry A Wallace Beltsville Agr Res Ctr, USDA, Beltsville, MD 20705 USA. [Liu, Liu; Meng, Jianghong] Univ Maryland, Dept Food Sci & Nutr, College Pk, MD 20742 USA. [Boren, Tara L.; Ranallo, Ryan T.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD USA. RP Bhagwat, AA (reprint author), ARS, Environm Microbial & Food Safety Lab, Henry A Wallace Beltsville Agr Res Ctr, USDA, 10300 Baltimore Ave,Bldg 002,BARC W, Beltsville, MD 20705 USA. EM arvind.bhagwat@ars.usda.gov RI Dharne, Mahesh/K-3541-2012; OI Kannan, Porteen/0000-0002-6925-328X FU China Scholarship Council; Ministry of Education, China FX The study was supported in part by the China Scholarship Council, Ministry of Education, China (LL). We would like to thank Malabi Venkatesan for support of this project. The content of this publication does not necessarily reflect the views or policies of the US Department of the Army, US Department of Agriculture or the US Department of Defense nor does the mention of trade names, commercial products, or organizations imply endorsement by the US Government. NR 27 TC 3 Z9 3 U1 0 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0302-8933 J9 ARCH MICROBIOL JI Arch. Microbiol. PD MAR PY 2010 VL 192 IS 3 BP 167 EP 174 DI 10.1007/s00203-009-0538-z PG 8 WC Microbiology SC Microbiology GA 554SV UT WOS:000274455600003 PM 20062978 ER PT J AU Nadeau, DP Rich, JN Brietzke, SE AF Nadeau, Daniel P. Rich, Jeremy N. Brietzke, Scott E. TI Informed Consent in Pediatric Surgery Do Parents Understand the Risks? SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Article ID NECK-SURGERY; OTITIS-MEDIA; INFANTS; HEAD AB Objective: To investigate parent understanding of the risks of pediatric ear, nose, and throat surgery after counseling with and Without the use of informational aids. Design: Prospective, randomized trial. Setting: Academic tertiary care center Participants: Parents of children undergoing car, nose, and throat surgery. Interventions: Parents were randomized to receive standard informed consent with or without detailed information aids. Main Outcome Measures: Parents completed identical questionnaires testing their general procedure knowledge and their recall of 9 specific surgical risks both immediately after counseling and on the day of surgery. Results: Thirty-four parents enrolled in and completed the study (18 in the control group and 1.6 in the test group). The mean time from informed consent to surgery was 6.3 days (range, 1-22 days). Parents in the test group scored significantly higher on identifying the 9 risks on both the preoperative questionnaire (mean score, 6.00 vs 4.44; P=.007, 2-tailed t test) and the postoperative questionnaire (6.25 vs 4.17; P<.001). There was a negative correlation (inverse relationship) between parent education score and risk recall, with parents with lower education levels scoring higher on both the preoperative (Pearson r=-0.36; P=.04) and the postoperative (r=-0.35; P=.04) surveys. The maternal parent recalled risks significantly better than the paternal parent, with surgical risk recall scores of 5.46 out of 9 vs 3.67 Out Of 9 (P=.02, 2-tailed t test). Conclusions: Parents of children undergoing car, nose, and throat surgery recall far less than 100% of courseled risks. The use of detailed surgical risk counseling improves measured parental understanding Of Surgical risk. Parental educational level and maternal vs paternal parent may affect risk counseling recall. C1 [Nadeau, Daniel P.; Rich, Jeremy N.; Brietzke, Scott E.] Walter Reed Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Washington, DC 20307 USA. RP Brietzke, SE (reprint author), Walter Reed Army Med Ctr, Dept Otolaryngol Head & Neck Surg, 6900 Georgia Ave, Washington, DC 20307 USA. EM scott.brietzke@amedd.army.mil NR 16 TC 16 Z9 16 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0886-4470 J9 ARCH OTOLARYNGOL JI Arch. Otolaryngol. Head Neck Surg. PD MAR PY 2010 VL 136 IS 3 BP 265 EP 269 PG 5 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 569FI UT WOS:000275581600009 PM 20231645 ER PT J AU Reed, J Mans, CK Brietzke, SE AF Reed, Jeremy Mans, Carolyn K. Brietzke, Scott E. TI Statistics or Ethics? Decision to Treat Drooling Reply SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Letter C1 [Reed, Jeremy; Mans, Carolyn K.; Brietzke, Scott E.] Walter Reed Army Med Ctr, Dept Otolaryngol, Washington, DC 20307 USA. RP Brietzke, SE (reprint author), Walter Reed Army Med Ctr, Dept Otolaryngol, 6900 Georgia Ave, Washington, DC 20307 USA. EM scott.brietzke@amedd.army.rnil OI Brietzke, Scott/0000-0002-2844-6026 NR 2 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0886-4470 J9 ARCH OTOLARYNGOL JI Arch. Otolaryngol. Head Neck Surg. PD MAR PY 2010 VL 136 IS 3 BP 315 EP 316 PG 2 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 569FI UT WOS:000275581600023 ER PT J AU Yildirim, ED Besunder, R Pappas, D Allen, F Guceri, S Sun, W AF Yildirim, Eda D. Besunder, Robyn Pappas, Daphne Allen, Fred Guceri, Selcuk Sun, Wei TI Accelerated differentiation of osteoblast cells on polycaprolactone scaffolds driven by a combined effect of protein coating and plasma modification SO BIOFABRICATION LA English DT Article ID FIBRONECTIN CONFORMATION; TISSUE SCAFFOLDS; PROLIFERATION; ADHESION; DEPOSITION; BIOMATERIALS; ATTACHMENT; PHENOTYPE; FIBER AB A combined effect of protein coating and plasma modification on the quality of the osteoblast-scaffold interaction was investigated. Three-dimensional polycaprolactone (PCL) scaffolds were manufactured by the precision extrusion deposition (PED) system. The structural, physical, chemical and biological cues were introduced to the surface through providing 3D structure, coating with adhesive protein fibronectin and modifying the surface with oxygen-based plasma. The changes in the surface properties of PCL after those modifications were examined by contact angle goniometry, surface energy calculation, surface chemistry analysis (XPS) and surface topography measurements (AFM). The effects of modification techniques on osteoblast short-term and long-term functions were examined by cell adhesion, proliferation assays and differentiation markers, namely alkaline phosphatase activity (ALP) and osteocalcin secretion. The results suggested that the physical and chemical cues introduced by plasma modification might be sufficient for improved cell adhesion, but for accelerated osteoblast differentiation the synergetic effects of structural, physical, chemical and biological cues should be introduced to the PCL surface. C1 [Yildirim, Eda D.; Guceri, Selcuk; Sun, Wei] Drexel Univ, Dept Mech Engn & Mech, Philadelphia, PA 19104 USA. [Besunder, Robyn; Allen, Fred] Drexel Univ, Sch Biomed Engn Sci & Hlth Syst, Philadelphia, PA 19104 USA. [Pappas, Daphne] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Yildirim, ED (reprint author), Drexel Univ, Dept Mech Engn & Mech, 3141 Chestnut St, Philadelphia, PA 19104 USA. EM edy22@drexel.edu OI Pappas, Daphne/0000-0002-5746-8873 NR 29 TC 36 Z9 36 U1 2 U2 14 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 1758-5082 EI 1758-5090 J9 BIOFABRICATION JI Biofabrication PD MAR PY 2010 VL 2 IS 1 AR 014109 DI 10.1088/1758-5082/2/1/014109 PG 12 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA 602DJ UT WOS:000278118400010 PM 20811124 ER PT J AU Hari, PN Majhail, NS Zhang, MJ Hassebroek, A Siddiqui, F Ballen, K Bashey, A Bird, J Freytes, CO Gibson, J Hale, G Holmberg, L Kamble, R Kyle, RA Lazarus, HM LeMaistre, CF Loberiza, F Maiolino, A McCarthy, PL Milone, G Omondi, N Reece, DE Seftel, M Trigg, M Vesole, D Weiss, B Wiernik, P Lee, SJ Rizzo, JD Mehta, P AF Hari, Parameswaran N. Majhail, Navneet S. Zhang, Mei-Jie Hassebroek, Anna Siddiqui, Fareeha Ballen, Karen Bashey, Asad Bird, Jenny Freytes, Cesar O. Gibson, John Hale, Gregaory Holmberg, Leona Kamble, Ram Kyle, Robert A. Lazarus, Hillard M. LeMaistre, Charles F. Loberiza, Fausto Maiolino, Angelo McCarthy, Philip L. Milone, Gustavo Omondi, Nancy Reece, Donna E. Seftel, Matthew Trigg, Michael Vesole, David Weiss, Brendan Wiernik, Peter Lee, Stephanie J. Rizzo, J. Douglas Mehta, Paulette TI Race and Outcomes of Autologous Hematopoietic Cell Transplantation for Multiple Myeloma SO BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION LA English DT Article DE Autologous hematopoietic cell transplantation; Multiple myeloma; Race; Survival; Progression-free survival ID AFRICAN-AMERICAN PATIENTS; UNITED-STATES VETERANS; UNDETERMINED SIGNIFICANCE; MONOCLONAL GAMMOPATHY; SOCIOECONOMIC-STATUS; SURVIVAL; CANCER; CHEMOTHERAPY; WHITE; RISK AB Blacks are twice as likely to develop and die from multiple myeloma (MM), and are less likely to receive an autologous hematopoietic-cell transplant (AHCT) for MM compared to Whites. The influence of race on outcomes of AHCT for MM is not well described. We compared the probability of overall survival (OS), progression-free survival (PFS), disease progression, and nonrelapse mortality (NRM) among Black (N = 303) and White (N = 1892) recipients of AHCT for MM, who were reported to the Center for International Blood and Marrow Transplant Research (CIBMTR) from 1995 to 2005. The Black cohort was more likely to be female, and had better Karnofsky performance scores, but lower hemoglobin and albumin levels at diagnosis. Black recipients were younger and more likely to be transplanted later in their disease course. Disease stage and treatment characteristics prior to AHCT were similar between the 2 groups. Black and White recipients had similar probabilities of 5-year OS (52% versus 47%, P = .19) and PFS (19% versus 21%, P = .64) as well as cumulative incidences of disease progression (72% versus 72%, P = .97) and NRM (9% versus 8%, P = .52). In multivariate analyses, race was not associated with any of these endpoints. Black recipients of AHCT for MM have similar outcomes compared to Whites, suggesting that the reasons underlying lower rates of AHCT in Blacks need to be studied further to ensure equal access to effective therapy. Biol Blood Marrow Transplant 16: 395-402 (2010) (C) 2010 American Society for Blood and Marrow Transplantation C1 [Hari, Parameswaran N.; Zhang, Mei-Jie; Lee, Stephanie J.; Rizzo, J. Douglas] Med Coll Wisconsin, CIBMTR, Milwaukee, WI 53226 USA. [Majhail, Navneet S.; Hassebroek, Anna] Ctr Int Blood & Marrow Transplant Res, Natl Marrow Donor Program, Minneapolis, MN USA. [Majhail, Navneet S.] Univ Minnesota, Minneapolis, MN USA. [Ballen, Karen] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Bashey, Asad] Blood & Marrow Transplant Grp Georgia, Atlanta, GA USA. [Bird, Jenny] Bristol Haematol & Oncol Ctr, Bristol, Avon, England. [Freytes, Cesar O.] S Texas Vet Hlth Care Syst, San Antonio, TX USA. [Freytes, Cesar O.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Gibson, John] Royal Prince Alfred Hosp, Camperdown, NSW 2050, Australia. [Hale, Gregaory] Childrens Hosp, St Petersburg, FL USA. [Holmberg, Leona] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Kamble, Ram] Baylor Coll Med, Houston, TX 77030 USA. [Kyle, Robert A.] Mayo Clin, Rochester, MN USA. [Lazarus, Hillard M.] Univ Hosp Cleveland, Case Med Ctr, Cleveland, OH 44106 USA. [LeMaistre, Charles F.] Texas Transplant Inst, San Antonio, TX USA. [Loberiza, Fausto] Univ Nebraska Med Ctr, Omaha, NE USA. [Maiolino, Angelo] Hosp Univ Clementino Frago Filho, Rio De Janeiro, Brazil. [McCarthy, Philip L.] Roswell Pk Canc Inst, Buffalo, NY 14263 USA. [Milone, Gustavo] Angelica Ocampo Hosp & Res Ctr, Fundaleu Buenos Aires, Argentina. [Reece, Donna E.] Univ Toronto, Toronto, ON, Canada. [Seftel, Matthew] CancerCare Manitoba, Morden, MB, Canada. [Trigg, Michael] Merck & Co Inc, Wilmington, DE USA. [Vesole, David] Loyola Univ Hlth Syst, Maywood, IL USA. [Weiss, Brendan] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Wiernik, Peter] New York Med Coll, Bronx, NY USA. [Mehta, Paulette] Univ Arkansas, Little Rock, AR 72204 USA. RP Hari, PN (reprint author), Med Coll Wisconsin, CIBMTR, POB 26509,8701 Watertown Plank Rd, Milwaukee, WI 53226 USA. EM phari@mcw.edu OI Hari, Parameswaran/0000-0002-8800-297X FU National Cancer Institute (NCI) [U24-CA76518]; National Heart, Lung and Blood Institute (NHLBI) [5U01HL069294]; National Institute of Allergy and Infectious Diseases (NIAID); Health Resources and Services Administration (HRSA/DHHS) [HHSH234200637015C]; Office of Naval Research [N00014-06-1-0704, N00014-08-1-0058]; AABB; Aetna; American Society for Blood and Marrow Transplantation; Amgen, Inc. FX The CIBMTR is supported by Public Health Service Grant/Cooperative Agreement U24-CA76518 from the National Cancer Institute (NCI), the National Heart, Lung and Blood Institute (NHLBI), and the National Institute of Allergy and Infectious Diseases (NIAID); a Grant/Cooperative Agreement 5U01HL069294 from NHLBI and NCI; a contract HHSH234200637015C with Health Resources and Services Administration (HRSA/DHHS); 2 Grants N00014-06-1-0704 and N00014-08-1-0058 from the Office of Naval Research; and grants from AABB; Aetna; American Society for Blood and Marrow Transplantation; Amgen, Inc.; anonymous donation to the Medical College of Wisconsin; Association of Medical Microbiology and Infectious Disease Canada; Astellas Pharma US, Inc.; Baxter International, Inc.; Bayer HealthCare Pharmaceuticals; Blood Center of Wisconsin; Blue Cross and Blue Shield Association; Bone Marrow Foundation; Canadian Blood and Marrow Transplant Group; Celgene Corporation; CellGenix, GmbH; Centers for Disease Control and Prevention; ClinImmune Labs; CTI Clinical Trial and Consulting Services; Cubist Pharmaceuticals; Cylex Inc.; CytoTherm; DOR BioPharma, Inc.; Dynal Biotech, an Invitrogen Company; Enzon Pharmaceuticals, Inc.; European Group for Blood and Marrow Transplantation; Gambro BCT, Inc.; Gamida Cell, Ltd.; Genzyme Corporation; Histogenetics, Inc.; HKS Medical Information Systems; Hospira, Inc.; Infectious Diseases Society of America; Kiadis Pharma; Kirin Brewery Co., Ltd.; Merck & Company; The Medical College of Wisconsin; MGI Pharma, Inc.; Michigan Community Blood Centers; Millennium Pharmaceuticals, Inc.; Miller Pharmacal Group; Milliman USA, Inc.; Miltenyi Biotec, Inc.; National Marrow Donor Program; Nature Publishing Group; New York Blood Center; Novartis Oncology; Oncology Nursing Society; Osiris Therapeutics, Inc.; Otsuka Pharmaceutical Development & Commercialization, Inc.; Pall Life Sciences; PDL BioPharma, Inc; Pfizer Inc; Pharmion Corporation; Saladax Biomedical, Inc.; Schering Plough Corporation; Society for Healthcare Epidemiology of America; StemCyte, Inc.; StemSoft Software, Inc.; Sysmex; Teva Pharmaceutical Industries; The Marrow Foundation; THERAKOS, Inc.; Vidacare Corporation; Vion Pharmaceuticals, Inc.; ViraCor Laboratories; ViroPharma, Inc.; and Wellpoint, Inc. NR 28 TC 21 Z9 21 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1083-8791 EI 1523-6536 J9 BIOL BLOOD MARROW TR JI Biol. Blood Marrow Transplant. PD MAR PY 2010 VL 16 IS 3 BP 395 EP 402 DI 10.1016/j.bbmt.2009.11.007 PG 8 WC Hematology; Immunology; Transplantation SC Hematology; Immunology; Transplantation GA 584DO UT WOS:000276730800012 PM 19922808 ER PT J AU Du, YN Hancock, MJ He, JK Villa-Uribe, JL Wang, B Cropek, DM Khademhosseini, A AF Du, Yanan Hancock, Matthew J. He, Jiankang Villa-Uribe, Jose L. Wang, Ben Cropek, Donald M. Khademhosseini, Ali TI Convection-driven generation of long-range material gradients SO BIOMATERIALS LA English DT Article DE Anisotropic materials; Composite materials; Microfluidics; Gradients ID RECTANGULAR CONDUITS; FLUORESCENCE RECOVERY; MICROFLUIDIC DEVICE; LAMINAR DISPERSION; HYALURONIC-ACID; SELF-DIFFUSION; CELL-GROWTH; CHEMOTAXIS; SCAFFOLDS; FLOWS AB Natural materials exhibit anisotropy with variations in soluble factors, cell distribution, and matrix properties The ability to recreate the heterogeneity of the natural materials is a major challenge for investigating cell-material interactions and for developing biomimetic: materials Here we present a generic fluidic approach using convection and alternating flow to rapidly generate multi-centimeter gradients of biomolecules, polymers, beads and cells and cross-gradients of two species in a microchannel. Accompanying theoretical estimates and simulations of gradient growth provide design criteria over a range of material properties A poly(ethylene-glycol) hydrogel gradient. a Porous collagen gradient and a composite material with a hyaluronic acid/gelatin cross-gradient were generated with continuous variations in material properties and in their ability to regulate cellular response This simple yet generic fluidic platform should prove useful for creating anisotropic biomimetic materials and high-throughput platforms for investigating cell-microenvironment interactions (C) 2009 Elsevier Ltd All rights reserved. C1 [Du, Yanan; Hancock, Matthew J.; He, Jiankang; Villa-Uribe, Jose L.; Wang, Ben; Khademhosseini, Ali] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med,Ctr Biomed Engn, Cambridge, MA 02139 USA. [Du, Yanan; Hancock, Matthew J.; He, Jiankang; Villa-Uribe, Jose L.; Wang, Ben; Khademhosseini, Ali] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA. [He, Jiankang] Xi An Jiao Tong Univ, State Key Lab Mfg Syst Engn, Xian 710049, Shaanxi, Peoples R China. [Cropek, Donald M.] USA, Corps Engineers, Construct Engn Res Lab, Champaign, IL 61822 USA. RP Khademhosseini, A (reprint author), Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med,Ctr Biomed Engn, Cambridge, MA 02139 USA. RI Hancock, Matthew/G-3859-2010; Khademhosseini, Ali/A-9435-2010; Wang, Ben/B-6488-2011; OI Hancock, Matthew/0000-0001-9820-3620; Khademhosseini, Ali/0000-0002-2692-1524; Wang, Ben/0000-0002-4134-1835; Khademhosseini, Ali/0000-0001-6322-8852 FU US Army Engineer Research and Development Center; Institute for Soldier Nanotechnology; NIH [HL092836, DE019024, EB007249]; National Science Foundation; China Scholarship Council (CSC); Program for Changjiang Scholars and Innovative Research Team in University, China [IRT0646] FX This research was funded by the US Army Engineer Research and Development Center, the Institute for Soldier Nanotechnology, the NIH (HL092836, DE019024. EB007249), and the National Science Foundation CAREER award (AK). YD was supported by an appointment to the postgraduate research participation program at the US Army Engineer Research and Development Center, Construction Engineering Research Laboratory (ERDC-CERL), administered by the Oak Ridge Institute for Science and Education JH was partially sponsored by the China Scholarship Council (CSC), the Program for Changjiang Scholars and Innovative Research Team in University (IRT0646), China. Comsol was provided through the CrimsonGrid initiative at Harvard University. We would like to thank Dr. Jaesool Shim, Dr. Jason Nichol, Dr. Lianyong Wang, and Dr Ian Wheeldon for scientific and technical support. NR 35 TC 41 Z9 41 U1 5 U2 29 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0142-9612 J9 BIOMATERIALS JI Biomaterials PD MAR PY 2010 VL 31 IS 9 BP 2686 EP 2694 DI 10.1016/j.biomaterials.2009.12.012 PG 9 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA 566CX UT WOS:000275348800026 PM 20035990 ER PT J AU Park, JP Cropek, DM Banta, S AF Park, Jong Pil Cropek, Donald M. Banta, Scott TI High Affinity Peptides for the Recognition of the Heart Disease Biomarker Troponin I Identified Using Phage Display SO BIOTECHNOLOGY AND BIOENGINEERING LA English DT Article DE troponin I; phage display; cardiac biomarker; peptide recognition sequences; homolog specificity ID BIOLOGICAL THREAT AGENTS; MYOCARDIAL-INFARCTION; MOLECULAR RECOGNITION; CARDIAC INJURY; PROTEIN; ASSAY; LIBRARIES; TECHNOLOGIES; ELECTRODES; LIGANDS AB Troponin I is a specific and sensitive clinical biomarker for myocardial injury. In this Study we have used polyvalent phage display to isolate unique linear peptide motifs which recognize both the human and rat homologs of troponin I. The peptide specific for human troponin I has a sequence of FYSHSFHENWPS and the peptide specific for the rat troponin I has a sequence of FHSSWPVNGSTI. Enzyme-linked immunosorbent assays (ELISAs) were used to evaluate the binding interactions, and the two phage-displayed peptides exhibited some cross-reactivity, but they were both more specific for the troponin I homolog they were selected against. The binding affinities of the phage-displayed peptides were decreased by the presence of complex tissue culture media (MEM), and the addition of 10% calf serum further interfered with the binding of the target proteins. Kinetic indirect phage ELISAs revealed that both troponin I binding peptides were found to have nanomolar affinities for the troponin proteins while attached to the phage particles. To our knowledge, this is the first example of isolation and characterization of troponin I binders using phage display technology. These new peptides may have potential utility in the development of new clinical assays for cardiac injury as well as in monitoring of cardiac cells grown in culture. Biotechnol. Bioeng. 2010;105: 678-686. (C) 2009 Wiley Periodicals, Inc. C1 [Park, Jong Pil; Banta, Scott] Columbia Univ, Dept Chem Engn, New York, NY 10027 USA. [Cropek, Donald M.] USA, Construct Engn Res Lab, Engineer Res & Dev Ctr, Champaign, IL 61824 USA. RP Banta, S (reprint author), Columbia Univ, Dept Chem Engn, 500 W 120th St, New York, NY 10027 USA. EM sbanta@cheme.columbia.edu FU U.S. Army [W9132T-07-2-0008, W9132T-08-2-0002]; CERL; Oak Ridge Institute for Science and Engineering FX Contract grant sponsor: U.S. Army Basic Research Program Contract grant number: W9132T-07-2-0008; W9132T-08-2-0002; Funding was provided by the U.S. Army Basic Research Program and Columbia University was supported by the U.S. Army, CERL, Agreement No. W9132T-07-2-0008 and Agreement No. W9132T-08-20002. J.P. Park is grateful to CERL and the Oak Ridge Institute for Science and Engineering program for support. NR 47 TC 29 Z9 29 U1 10 U2 31 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0006-3592 J9 BIOTECHNOL BIOENG JI Biotechnol. Bioeng. PD MAR 1 PY 2010 VL 105 IS 4 BP 678 EP 686 DI 10.1002/bit.22597 PG 9 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 558KX UT WOS:000274742200002 PM 19891006 ER PT J AU Wehrum, MJ Hines, JF Hayes, EB Kost, ER Hall, KL Paidas, MJ AF Wehrum, Mark J. Hines, Jeffrey F. Hayes, Edwin B. Kost, Edward R. Hall, Kevin L. Paidas, Michael J. TI Comparative assessment of hypercoagulability in women with and without gynecologic malignancies using the thromboelastograph coagulation analyzer SO BLOOD COAGULATION & FIBRINOLYSIS LA English DT Article DE gynecologic malignancies; hypercoagulability; thromboelastograph coagulation analyzer ID CANCER-PATIENTS AB The hypercoagulability status of women with and without gynecologic malignancies was compared using the thromboelastograph coagulation analyzer. Blood specimens from 25 women with newly diagnosed gynecologic malignancies and from 21 age-matched controls were analyzed. Hypercoagulability is defined by a short R value (min), a short K value (min), an elevated maximum amplitude (MA) value (mm), and a broad alpha-angle (degrees). A two-tailed, two-sample t-test was used for statistical analysis. When compared with specimens from age-matched controls, specimens from women with gynecologic malignancies demonstrated values consistent with hypercoagulability. The specific parameters are presented as a mean (+/- SD). Patients with gynecologic malignancies were found to have a short R value (7.1 +/- 2.1 vs. 11.8 +/- 1.8 min; P<0.001), a short K value (3.1 +/- 0.9 vs. 4.6 +/- 0.9 min; P<0.001), a prolonged MA value (64.7 +/- 5.4 vs. 58.8 +/- 6.1 mm; P=0.001), and a greater alpha-angle (70.6 +/- 5.3 vs. 61.6 +/- 4.90; P<0.001). Detection of hypercoagulability as measured by thromboelastography is statistically more common among women with gynecologic malignancies compared with age-matched controls. Future studies may address the use of thromboelastography to identify patients at risk for gynecologic malignancies. Blood Coagul Fibrinolysis 21:140-143 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. C1 [Wehrum, Mark J.; Paidas, Michael J.] Yale Univ, Div Maternal Fetal Med, Dept Obstet Gynecol & Reprod Sci, Yale Women & Childrens Ctr Blood Disorders, New Haven, CT 06520 USA. [Wehrum, Mark J.; Hines, Jeffrey F.; Hayes, Edwin B.; Kost, Edward R.; Hall, Kevin L.] Brooke Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Houston, TX USA. RP Wehrum, MJ (reprint author), Yale Univ, Div Maternal Fetal Med, Dept Obstet Gynecol & Reprod Sci, Yale Women & Childrens Ctr Blood Disorders, 333 Cedar St,FMB 339B, New Haven, CT 06520 USA. EM Mark.Wehrum@Yale.Edu NR 15 TC 9 Z9 10 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0957-5235 J9 BLOOD COAGUL FIBRIN JI Blood Coagul. Fibrinolysis PD MAR PY 2010 VL 21 IS 2 BP 140 EP 143 DI 10.1097/MBC.0b013e3283358179 PG 4 WC Hematology SC Hematology GA 555LZ UT WOS:000274513600007 PM 20083998 ER PT J AU Brunye, TT Mahoney, CR Lieberman, HR Taylor, HA AF Brunye, Tad T. Mahoney, Caroline R. Lieberman, Harris R. Taylor, Holly A. TI Caffeine modulates attention network function SO BRAIN AND COGNITION LA English DT Article DE Caffeine; Arousal; Attention networks; Visuospatial attention ID ANTERIOR CINGULATE CORTEX; WORKING-MEMORY; PREFRONTAL CORTEX; PSYCHOMOTOR PERFORMANCE; SELECTIVE ATTENTION; COGNITIVE PERFORMANCE; INHIBITORY CONTROL; CEREBRAL-CORTEX; DOPAMINE; MOOD AB The present work investigated the effects of caffeine (0 mg. 100 mg, 200 mg, 400 mg) on a flanker task designed to test Posner's three visual attention network functions: alerting, orienting, and executive control [Posner, M. I. (2004). Cognitive neuroscience of attention. New York, NY: Guilford Press]. In a placebo-controlled, double-blind study using a repeated-measures design, we found that the effects of caffeine on visual attention vary as a function of dose and the attention network under examination. Caffeine improved alerting and executive control function in a dose-response manner, asymptoting at 200 mg; this effect is congruent with caffeine's adenosine-mediated effects on dopamine-rich areas of brain, and the involvement of these areas in alerting and the executive control of visual attention. Higher doses of caffeine also led to a marginally less efficient allocation of visual attention towards cued regions during task performance (i.e., orienting). Taken together, results of this study demonstrate that caffeine has differential effects on visual attention networks as a function of dose, and such effects have implications for hypothesized interactions of caffeine, adenosine and dopamine in brain areas mediating visual attention. Published by Elsevier Inc. C1 [Brunye, Tad T.; Mahoney, Caroline R.; Taylor, Holly A.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. [Brunye, Tad T.; Mahoney, Caroline R.] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA USA. [Lieberman, Harris R.] USA, Environm Med Res Inst, Washington, DC USA. RP Brunye, TT (reprint author), Tufts Univ, Dept Psychol, 490 Boston Ave, Medford, MA 02155 USA. EM tbruny01@tufts.edu NR 94 TC 39 Z9 45 U1 2 U2 26 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0278-2626 J9 BRAIN COGNITION JI Brain Cogn. PD MAR PY 2010 VL 72 IS 2 BP 181 EP 188 DI 10.1016/j.bandc.2009.07.013 PG 8 WC Neurosciences; Psychology, Experimental SC Neurosciences & Neurology; Psychology GA 555LP UT WOS:000274512600004 PM 19733954 ER PT J AU Popentiu, AI Weber-Lauer, C Nieman, C Kauvar, DS Sabau, D AF Popentiu, A. I. Weber-Lauer, C. Nieman, C. Kauvar, D. S. Sabau, D. TI Late presentation of a shrapnel wound-induced traumatic intra-thoracic abdominal evisceration, as colon perforation with left faecopneumothorax SO CHIRURGIA LA English DT Article DE intra-thoracic evisceration; complication; faeco-pneumothorax ID DIAPHRAGMATIC RUPTURE AB The diaphragmatic hernia is a well recognized and common complication of both the penetrating and blunt thoraco-abdominal trauma. The clinical presentation is eather in the acute phase, or later, when it features the symptoms of obstructive complications. The aim of the study is to report a case of delayed presentation of a blast wound with diaphragmatic hernia, complicated by herniation and perforation of the left colonic angle in the pleural cavity. The report highlights the multiple complications following the initial event and the staged management of the case. C1 [Popentiu, A. I.] Emergency Mil Hosp Sibiu, Dept Surg, Sibiu, Romania. [Popentiu, A. I.; Weber-Lauer, C.; Nieman, C.; Kauvar, D. S.] 115th Combat Support Hosp Baghdad, Baghdad, Iraq. [Weber-Lauer, C.] Bayne Jones Army Community Hosp, Dept Surg, Ft Polk, LA USA. [Nieman, C.] Womack Army Med Ctr, Dept Radiol, Ft Bragg, NC USA. [Kauvar, D. S.] Univ Utah, Sch Med, Salt Lake City, UT 84112 USA. [Kauvar, D. S.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. [Sabau, D.] Victor Papilian Fac Med, Dept Surg Prof, Sibiu, Romania. RP Popentiu, AI (reprint author), Emergency Mil Hosp, Dept Surg, B Dul Victoriei 44-46 Sibiu, Sibiu, Romania. EM adipopentiu@yahoo.com RI Florin, Popentiu/E-5787-2010 NR 10 TC 0 Z9 0 U1 0 U2 0 PU EDITURA CELSIUS PI BUCHAREST PA STR LITOVOI VOIEVOD NR 1, BL OD7A, SC A, AP 20, SECTOR 2, BUCHAREST, 00000, ROMANIA SN 1221-9118 J9 CHIRURGIA-BUCHAREST JI Chirurgia PD MAR-APR PY 2010 VL 105 IS 2 BP 253 EP 256 PG 4 WC Surgery SC Surgery GA 593OG UT WOS:000277467300019 PM 20540242 ER PT J AU Rice, KR Chen, YM Ali, A Whitman, EJ Blase, A Ibrahim, M Elsamanoudi, S Brassell, S Furusato, B Stingle, N Sesterhenn, IA Petrovics, G Miick, S Rittenhouse, H Groskopf, J McLeod, DG Srivastava, S AF Rice, Kevin R. Chen, Yongmei Ali, Amina Whitman, Eric J. Blase, Amy Ibrahim, Mona Elsamanoudi, Sally Brassell, Stephen Furusato, Bungo Stingle, Norbert Sesterhenn, Isabell A. Petrovics, Gyorgy Miick, Siobhan Rittenhouse, Harry Groskopf, Jack McLeod, David G. Srivastava, Shiv TI Evaluation of the ETS-Related Gene mRNA in Urine for the Detection of Prostate Cancer SO CLINICAL CANCER RESEARCH LA English DT Article ID TMPRSS2-ERG FUSION TRANSCRIPTS; PCA3; MEN; DIAGNOSIS; BIOPSY; ASSAY AB Purpose: Prevalent gene fusions in prostate cancer involve androgen-regulated promoters (primarily TMPRSS2) and ETS transcription factors (predominantly ETS-regulated gene (ERG)], which result in tumor selective overexpression of ERG in two thirds of patients. Because diverse genomic fusion events lead to ERG overexpression in prostate cancer, we reasoned that it may be more practical to capture such alterations using an assay targeting ERG sequences retained in such gene fusions. This study evaluates the potential of an assay quantitating ERG mRNA in post-digital rectal exam (DRE) urine for improving prostate cancer detection. Experimental Design: Patients scheduled to undergo transrectal ultrasound-guided needle biopsy of the prostate were prospectively enrolled. On the day of biopsy, patients provided a urine sample immediately following a DRE. Urine ERG mRNA was measured and normalized to urine prostate-specific antigen (PSA) mRNA using the DTS 400 system. Demographic traits, clinical characteristics and biopsy results were analyzed for association with urine ERG score. Results: The study was conducted on 237 patients. Prostate cancer was shown on biopsy in 40.9% of study subjects. A higher urine ERG score associated significantly with malignancy on biopsy (P = 0.0145), but not with clinical stage or Gleason score. Urine ERG score performed best in Caucasians and in men with a PSA of <= 4 ng/mL (area under the curve = 0.8). Conclusions: A higher urine ERG score in post-DRE urine is associated with the diagnosis of prostate cancer on biopsy. Urine ERG score performed particularly well in men with a PSA of <= 4.0 ng/mL, a segment of the screening population in which further diagnostic markers are needed to determine in whom biopsy should be done. Clin Cancer Res; 16(5); 1572-6. (C)2010 AACR. C1 [Chen, Yongmei; Brassell, Stephen; Stingle, Norbert; Petrovics, Gyorgy; McLeod, David G.; Srivastava, Shiv] Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Dept Surg, Rockville, MD USA. [Rice, Kevin R.; Ali, Amina; Whitman, Eric J.; Ibrahim, Mona; Elsamanoudi, Sally; Brassell, Stephen; McLeod, David G.] Walter Reed Army Med Ctr, Serv Urol, Washington, DC 20307 USA. [Furusato, Bungo; Sesterhenn, Isabell A.] Armed Forces Inst Pathol, Dept Genitourinary Pathol, Washington, DC 20306 USA. [Blase, Amy; Miick, Siobhan; Rittenhouse, Harry; Groskopf, Jack] Gen Probe Inc, San Diego, CA USA. RP Srivastava, S (reprint author), Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, 1530 E Jefferson St, Rockville, MD 20852 USA. EM David.McLeod@amedd.army.mil; ssrivastava@cpdr.org OI Furusato, Bungo/0000-0003-4614-9882 NR 18 TC 32 Z9 35 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1078-0432 J9 CLIN CANCER RES JI Clin. Cancer Res. PD MAR 1 PY 2010 VL 16 IS 5 BP 1572 EP 1576 DI 10.1158/1078-0432.CCR-09-2191 PG 5 WC Oncology SC Oncology GA 607ZJ UT WOS:000278545500024 PM 20160063 ER PT J AU Lehman, RA Lenke, LG Helgeson, MD Eckel, TT Keeler, KA AF Lehman, Ronald A., Jr. Lenke, Lawrence G. Helgeson, Melvin D. Eckel, Tobin T. Keeler, Kathryn A. TI Do Intraoperative Radiographs in Scoliosis Surgery Reflect Radiographic Result? SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article ID ADOLESCENT IDIOPATHIC SCOLIOSIS; PEDICLE SCREW PLACEMENT; POSTERIOR SPINAL-FUSION; PLAIN RADIOGRAPHS; COMPUTED-TOMOGRAPHY; VERTEBRAL ROTATION; ACCURACY; FIXATION; INSTRUMENTATION; DEFORMITIES AB It is often difficult to predict postoperative radiographic curve magnitude and balance parameters while performing intraoperative correction during scoliosis surgery. We asked whether there was a radiographic correlation between intraoperative long-cassette scoliosis film and postoperative standing radiographs of adolescent idiopathic scoliosis with pedicle screw instrumentation. We retrospectively reviewed 44 patients with adolescent idiopathic scoliosis who underwent posterior instrumentation with pedicle screws. We made preoperative, intraoperative (after instrumentation and correction), and standing postoperative radiographic measurements (eg, curve magnitudes, coronal and sagittal balance, disc angles) and compared those for the intra- and postoperative radiographs. The intraoperative long-cassette scoliosis film correlated with the immediate postoperative standing film for all curve correction and balance parameters. The routine use of a long-cassette intraoperative scoliosis film provides the surgeon with a valuable tool to guide intraoperative decision-making and foreshadows the correction and balance obtained on the immediate postoperative film. Level of Evidence: Level IV, retrospective study. See Guidelines for Authors for a complete description of levels of evidence. C1 [Lehman, Ronald A., Jr.] Walter Reed Army Med Ctr, Potomac, MD 20854 USA. [Helgeson, Melvin D.; Eckel, Tobin T.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Orthopaed Surg Serv, Washington, DC 20307 USA. [Lenke, Lawrence G.; Keeler, Kathryn A.] Washington Univ, Sch Med, Dept Orthopaed Surg, St Louis, MO USA. RP Lehman, RA (reprint author), Walter Reed Army Med Ctr, 1528 Blue Meadow Rd, Potomac, MD 20854 USA. EM armyspine@yahoo.com FU Medtronic; DePuy; Axial Biotech; Quality Medical Publishing FX One or more of the authors (LGL) has received funding from Medtronic, DePuy, Axial Biotech, and Quality Medical Publishing. Each author certifies that his or her institution has approved the human protocol for this investigation, that all investigations were conducted in conformity with ethical principles of research, and that informed consent for participation in the study was obtained. This work was performed at the Walter Reed Army Medical Center, Washington, DC, and Washington University School of Medicine, St Louis, MO. NR 25 TC 4 Z9 4 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0009-921X J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD MAR PY 2010 VL 468 IS 3 BP 679 EP 686 DI 10.1007/s11999-009-0873-z PG 8 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 558HM UT WOS:000274731700006 PM 19421829 ER PT J AU Dawood, M Taylor, E Rizkalla, S AF Dawood, M. Taylor, E. Rizkalla, S. TI Two-way bending behavior of 3-D GFRP sandwich panels with through-thickness fiber insertions SO COMPOSITE STRUCTURES LA English DT Article DE Sandwich construction; Membrane action; Plate bending; Non-linear analysis; Rational approach; Parametric study AB This paper presents the details of a research program that was conducted to evaluate the two-way bending behavior of 3-D glass fiber reinforced polymer (GFRP) sandwich panels. The panels consist of GFRP skins with a foam core and through-thickness fiber insertions. While the behavior of these panels under one-way bending is relatively well understood the behavior under two-way bending has not yet been investigated. An experimental program was conducted to evaluate the effect of the fiber insertion pattern and the panel thickness on the two-way bending behavior under the effect of a concentrated load. The experimental results were used to verify a non-linear, static finite element model which was used to introduce a simplified method to predict the behavior. The measured and predicted responses indicate that at lower deflections the panel behavior is dominated by plate bending action while for higher deflections membrane action dominates. The finite element analysis was extended to study the effect of different parameters which were not tested in the experimental program. The parametric study indicates that increasing the relative flexural or shear rigidities of the panel alters the behavior towards the plate bending mechanism thereby reducing the percentage of load carried by membrane action. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Dawood, M.] Univ Houston, Dept Civil & Environm Engn, Houston, TX 77204 USA. [Taylor, E.] USA, Corps Engineers, Area Off, Ft Bragg, NC 28310 USA. [Rizkalla, S.] N Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA. RP Dawood, M (reprint author), Univ Houston, Dept Civil & Environm Engn, N107 Engn Bldg 1,4800 Calhoun Rd, Houston, TX 77204 USA. EM mmdawood@uh.edu OI Dawood, Mina/0000-0003-1941-1240 FU Martin Marietta Composites through the National Science Foundation (NSF); Industry/University Cooperative Research Center (I/UCRC) [0741676] FX The authors would like to acknowledge the support of Martin Marietta Composites through the National Science Foundation (NSF) Industry/University Cooperative Research Center (I/UCRC) on Repair of Buildings and Bridges with Composites (RB2C), award number 0741676. The authors would like to thank Mr. Wesley Ballew for his support throughout the research program. The authors would also like to thank Dr. Halit Cenan Mertol and Mr. Charles DeVoto for their efforts in testing the one-way flexural specimens used to characterize the fundamental properties of the panels. NR 12 TC 12 Z9 12 U1 1 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0263-8223 J9 COMPOS STRUCT JI Compos. Struct. PD MAR PY 2010 VL 92 IS 4 BP 950 EP 963 DI 10.1016/j.compstruct.2009.09.040 PG 14 WC Materials Science, Composites SC Materials Science GA 547BD UT WOS:000273859000013 ER PT J AU Patel, AJ Sottos, NR Wetzel, ED White, SR AF Patel, Amit J. Sottos, Nancy R. Wetzel, Eric D. White, Scott R. TI Autonomic healing of low-velocity impact damage in fiber-reinforced composites SO COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING LA English DT Article DE Self-healing materials; Polymer-matrix composites (PMCs); Delamination; Impact behavior ID TOUGHENED EPOXY COMPOSITE; COMPRESSIVE STRENGTH; FATIGUE CRACKS; RESIDUAL STRENGTH; WOVEN COMPOSITES; REPAIR; POLYMER; PREDICTION; RETARDATION; CHALLENGES AB In this study autonomic self-healing of impact damage in composite materials is shown using a microen-capsulated healing agent. The components for self-healing, urea-formaldehyde microcapsules containing dicyclopentadiene (DCPD) liquid healing agent and paraffin wax microspheres containing 10 wt% Grubbs' catalyst, have been successfully incorporated in a woven S2-glass-reinforced epoxy composite. Low-velocity impact tests reveal that the self-healing composite panels are able to autonomically repair impact damage. Fluorescent labeling of damage combined with image processing shows that total crack length per imaged cross-section is reduced by 51% after self-healing. A testing protocol based on compression after impact reveals significant recovery of residual compressive strength (RCS) in self-healing panels. Self-healing panels show a higher threshold impact energy before RCS reduction, and as impact energy increases. RCS recovery decreases. Qualitative inspection shows that crack separation increases with increasing impact energy, indicating that self-healing performance depends on the ability to adequately fill damage volume. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Patel, Amit J.; Sottos, Nancy R.; White, Scott R.] Univ Illinois, Beckman Inst Adv Sci & Technol, Urbana, IL 61801 USA. [Patel, Amit J.; Sottos, Nancy R.] Univ Illinois, Dept Mat Sci & Engn, Urbana, IL 61801 USA. [Wetzel, Eric D.] USA, Res Lab, Div Mat, AMSRD ARL WM MA, Aberdeen Proving Ground, MD 21005 USA. [White, Scott R.] Univ Illinois, Dept Aerosp Engn, Urbana, IL 61801 USA. RP White, SR (reprint author), Univ Illinois, Beckman Inst Adv Sci & Technol, 405 N Mathews Ave, Urbana, IL 61801 USA. EM swhite@illinois.edu FU US Army Research Laboratory (ARL); U.S. Department of Energy FX Funding for this project is provided by the US Army Research Laboratory (ARL). The authors would like to thank Seth Ghiorse and Dan Baechle of ARL for helpful discussions. The authors would also like to thank John D. Williams and the Materials Testing Instructional Laboratory at the University of Illinois (UI) for use of the drop-weight impact tester. Other facilities used at UI include the Advanced Materials Testing and Engineering Laboratory, the Composites Manufacturing Laboratory, and the Beckman Institute for Advanced Science and Technology. Electron microscopy was carried out in the Center for Microanalysis of Materials at UI, which is supported by the U.S. Department of Energy. NR 51 TC 76 Z9 76 U1 2 U2 32 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-835X J9 COMPOS PART A-APPL S JI Compos. Pt. A-Appl. Sci. Manuf. PD MAR PY 2010 VL 41 IS 3 BP 360 EP 368 DI 10.1016/j.compositesa.2009.11.002 PG 9 WC Engineering, Manufacturing; Materials Science, Composites SC Engineering; Materials Science GA 557YJ UT WOS:000274706200004 ER PT J AU Derby, R deWeber, K AF Derby, Richard deWeber, Kevin TI The Athlete and High Altitude SO CURRENT SPORTS MEDICINE REPORTS LA English DT Review ID ACUTE MOUNTAIN-SICKNESS; PULMONARY-EDEMA; ILLNESS; PERFORMANCE; TREKKERS; ASCENT; LEVEL AB DERBY, R. and K. DEWEBER. The athlete and high altitude. Curr. Sports Med. Rep., Vol. 9, No. 2, pp. 79-85, 2010. Expanding athlete participation in high-altitude environments highlights the importance for a sports physician to have a good understanding of the high-altitude illness (HAI) syndromes: acute mountain sickness (AMS), high-altitude cerebral edema (HACE), and high-altitude pulmonary edema (HAPE). All may occur in the setting of acute altitude exposure higher than 2500 m; incidence and severity increases as altitudes or ascent rates increase. Once HAI is recognized, proven therapies should be instituted to alleviate symptoms and avert the possibility of critical illness. Allowing for acclimatization is the best strategy for preventing HAI. Acetazolamide and dexamethasone are additional preventive measures for AMS/HACE; nifedipine, salmeterol, and phosphodiesterase inhibitors are useful in preventing HAPE. Along with the immediate hazards of HAI with altitude exposure, the sport physician also should be familiar with altitude/hypoxic training practices used by athletes to enhance fitness and performance. C1 [Derby, Richard; deWeber, Kevin] Uniformed Serv Univ Hlth Sci, Tri Serv Mil Primary Care Sports Med Program, Bethesda, MD 20814 USA. [deWeber, Kevin] USA, Washington, DC USA. RP Derby, R (reprint author), Uniformed Serv Univ Hlth Sci, Tri Serv Mil Primary Care Sports Med Program, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM rderby@usuhs.mil NR 36 TC 2 Z9 4 U1 2 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1537-890X J9 CURR SPORT MED REP JI Curr. Sport. Med. Rep. PD MAR-APR PY 2010 VL 9 IS 2 BP 79 EP 85 DI 10.1249/JSR.0b013e3181d404ac PG 7 WC Sport Sciences SC Sport Sciences GA 570IY UT WOS:000275668100005 PM 20220348 ER PT J AU Atkins, JM Taylor, JC Kane, SF AF Atkins, Justin M. Taylor, Jonathan C. Kane, Shawn F. TI Acute and Overuse Injuries of the Abdomen and Groin in Athletes SO CURRENT SPORTS MEDICINE REPORTS LA English DT Review ID TRANSIENT ABDOMINAL-PAIN; REPAIR; HERNIA AB ATKINS, J.M., J.C. TAYLOR, and S.F. KANE. Acute and overuse injuries of the abdomen and groin in athletes. Curr. Sports Med. Rep., Vol. 9, No. 2, pp. 115-120, 2010. Abdominal and groin injuries are common problems encountered by athletes across a wide variety of sports. They range from benign but annoying, such as exercise-related transient abdominal pain ( ETAP), to the activity-limiting and possibly career-ending condition of athletic hernia. This article covers ETAP, rectus abdominus injuries, osteitis pubis, athletic hernia, and abdominal/groin hernias to provide an update on the current pathophysiology and treatment of common abdominal and pelvic conditions in the athlete. C1 [Atkins, Justin M.] Womack Army Med Ctr, Family Med Clin, Ft Bragg, NC 28301 USA. RP Atkins, JM (reprint author), Womack Army Med Ctr, Family Med Clin, Ft Bragg, NC 28301 USA. EM justin.atkins@us.army.mil NR 24 TC 5 Z9 5 U1 2 U2 17 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1537-890X J9 CURR SPORT MED REP JI Curr. Sport. Med. Rep. PD MAR-APR PY 2010 VL 9 IS 2 BP 115 EP 120 DI 10.1249/JSR.0b013e3181d40080 PG 6 WC Sport Sciences SC Sport Sciences GA 570IY UT WOS:000275668100012 PM 20220355 ER PT J AU Zaleski, L Turiansky, GW AF Zaleski, Lisa Turiansky, George W. TI Squamous Cell Carcinoma of the Anal Canal SO CUTIS LA English DT Review ID HUMAN-PAPILLOMAVIRUS INFECTION; CANCER; POPULATION AB Squamous cell carcinoma of the anal canal (SCCAC) is an increasing concern in the human immunodeficiency virus (HIV)-positive population in the highly active antiretroviral therapy (HAART) era. A discussion of the epidemiology, risk factors, clinical presentation, diagnosis, and treatment of SCCAC is presented, Cutis. 2010;85:143-145. C1 [Zaleski, Lisa] Expeditionary Hlth Serv Atlantic Fleet, Norfolk, VA USA. [Turiansky, George W.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Turiansky, George W.] Natl Capital Consortium Dermatol Residency Progra, Bethesda, MD USA. [Turiansky, George W.] Walter Reed Army Med Ctr, Dermatol Serv, Washington, DC 20307 USA. [Turiansky, George W.] Natl Naval Med Ctr, Dept Dermatol, Bethesda, MD USA. RP Zaleski, L (reprint author), Dept Dermatol, 34800 Bob Wilson Dr, San Diego, CA 92134 USA. NR 12 TC 1 Z9 1 U1 0 U2 0 PU QUADRANT HEALTHCOM INC PI PARSIPPANY PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA SN 0011-4162 J9 CUTIS JI Cutis PD MAR PY 2010 VL 85 IS 3 BP 143 EP 145 PG 3 WC Dermatology SC Dermatology GA 573GJ UT WOS:000275896300008 PM 20408513 ER PT J AU Kinnaird, KEH Sauerwein, TJ AF Kinnaird, Kate E. H. Sauerwein, Tom J. TI LACK OF CORRELATION BETWEEN 1,5-ANHYDROGLUCITOL ASSAY AND ORAL GLUCOSE TOLERANCE TEST IN PATIENTS WITH CYSTIC FIBROSIS SO ENDOCRINE PRACTICE LA English DT Article ID DIABETES-MELLITUS; PULMONARY-FUNCTION; MONITORING-SYSTEM; GLYCEMIA; LEVEL AB Objective: To determine whether the 1,5-anhydroglucitol (1,5-AG) assay, which reflects serum glucose levels during the preceding 2 weeks, could be used as an alternative to the current standard screening test for cystic fibrosis-related diabetes (CFRD)the oral glucose tolerance test (OGTT). Methods: Serum 1,5-AG, hemoglobin A1c (A1C), fructosamine, and glucose at various time intervals during the OGTT were measured in 10 patients, 19 to 36 years old, with cystic fibrosis. Correlation coefficients were calculated to compare 1,5-AG with A1C, fructosamine, and serum glucose levels during the OGTT, and the mean 1,5-AG, A1C, and fructosamine for normal glucose tolerance, impaired glucose tolerance (IGT), and CFRD were compared statistically. Results: On the basis of the 120-minute OGTT, 1 of the 10 study subjects had CFRD and 4 had IGT. The mean 1,5-AG for patients with normal glucose tolerance was not significantly different from that for patients with IGT (P = .063). The 1,5-AG value was not significantly correlated with serum glucose during the OGTT, A1C, or fructosamine. Conclusion: In this pilot study, we found no significant correlation between 1,5-AG and glucose values during the OGTT or between 1,5-AG and other glycemic markers. Hence, the utility of the 1,5-AG assay for screening for CFRD in the population of patients with cystic fibrosis may be limited. (Endocr Pract. 2010;16:167-170) C1 [Kinnaird, Kate E. H.] Walter Reed Army Med Ctr, Dept Endocrinol, Washington, DC 20307 USA. [Sauerwein, Tom J.] San Antonio Mil Med Ctr, Dept Endocrinol, Lackland AFB, TX USA. RP Kinnaird, KEH (reprint author), Walter Reed Army Med Ctr, Dept Endocrinol, 6900 Georgia Ave, Washington, DC 20307 USA. EM Kate.Kinnaird@us.army.mil FU Surgeon General's Office of the Department of the Air Force FX This study was funded by the Surgeon General's Office of the Department of the Air Force. We are grateful to Dr. Catherin Selloff and Dr. Stephen Derdak of the Wilford Hall Medical Center pulmonary clinic for their help in recruiting patients for this study. In addition, we thank Dr. Anneke Bush and Dr. Stephanie Fonda for their assistance with statistical analysis. Elliott Liezl and Terri Magram, our 2 metabolic nurses, were extremely helpful in collecting blood specimens and administering the OGTT. NR 27 TC 1 Z9 1 U1 0 U2 1 PU AMER ASSOC CLIN ENDOCRINOL PI JACKSONVILLE PA 1000 RIVERSIDE AVE, STE 205, JACKSONVILLE, FL 32204 USA SN 1530-891X J9 ENDOCR PRACT JI Endocr. Pract. PD MAR-APR PY 2010 VL 16 IS 2 BP 167 EP 170 DI 10.4158/EP09149.OR PG 4 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 593XU UT WOS:000277497400006 PM 19833588 ER PT J AU Matheny, RW Nindl, BC Adamo, ML AF Matheny, Ronald W., Jr. Nindl, Bradley C. Adamo, Martin L. TI Minireview: Mechano-Growth Factor: A Putative Product of IGF-I Gene Expression Involved in Tissue Repair and Regeneration SO ENDOCRINOLOGY LA English DT Review ID SKELETAL-MUSCLE HYPERTROPHY; STEM-CELL ACTIVATION; MESSENGER-RIBONUCLEIC-ACID; SATELLITE CELLS; SPLICE VARIANTS; PROPROTEIN CONVERTASES; MONOCLONAL-ANTIBODIES; PROGENITOR CELLS; FACTOR (IGF)-I; NITRIC-OXIDE AB The discovery that IGF-I mRNAs encoding isoforms of the pro-IGF-I molecule are differentially regulated in response to mechanical stress in skeletal muscle has been the impetus for a number of studies designed to demonstrate that alternative splicing of IGF-I pre-mRNA involving exons 4, 5, and 6 gives rise to a unique peptide derived from pro-IGF-I that plays a novel role in myoblast proliferation. Research suggests that after injury to skeletal muscle, the IGF-IEb mRNA splice variant is up-regulated initially, followed by up-regulation of the IGF-IEa splice variant at later time points. Up-regulation of IGF-IEb mRNA correlates with markers of satellite cell and myoblast proliferation, whereas up-regulation of IGF-IE amRNA is correlated with differentiation to mature myofibers. Due to the apparent role of IGF-IEb up-regulation in muscle remodeling, IGF-IEb mRNA was also named mechano-growth factor (MGF). A synthetically manufactured peptide (also termed MGF) corresponding to the 24 most C-terminal residues of IGF-IEb has been shown to promote cellular proliferation and survival. However, no analogous peptide product of the Igf1 gene has been identified in or isolated from cultured cells, their conditioned medium, or in vivo animal tissues or biological fluids. This review will discuss the relationship of the Igf1 gene to MGF and will differentiate actions of synthetic MGF from any known product of Igf1. Additionally, the role of MGF in satellite cell activation, aging, neuroprotection, and signaling will be discussed. A survey of outstanding questions relating to MGF will also be provided. (Endocrinology 151: 865-875, 2010) C1 [Matheny, Ronald W., Jr.; Nindl, Bradley C.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Adamo, Martin L.] Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem, San Antonio, TX 78229 USA. [Adamo, Martin L.] Univ Texas Hlth Sci Ctr San Antonio, Sam & Ann Barshop Inst Longev & Aging Studies, San Antonio, TX 78229 USA. RP Matheny, RW (reprint author), USA, Environm Med Res Inst, Mil Performance Div, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM ronald.matheny@us.army.mil RI Mat Zain, Mazatulikhma/B-2025-2010 FU National Institute [R01AG026012] FX This work was supported by National Institute on Aging Grant R01AG026012 to M.L.A. and an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Institute of Environmental Medicine administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and U.S. Army Medical Research and Materiel Command (R.W.M.). NR 82 TC 85 Z9 91 U1 1 U2 10 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0013-7227 J9 ENDOCRINOLOGY JI Endocrinology PD MAR PY 2010 VL 151 IS 3 BP 865 EP 875 DI 10.1210/en.2009-1217 PG 11 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 558AF UT WOS:000274711600007 PM 20130113 ER PT J AU Kwok, RM Moawad, FJ Laczek, JT Horwhat, JD AF Kwok, R. M. Moawad, F. J. Laczek, J. T. Horwhat, J. D. TI Intestinal endometriosis: an uncommon cause of rectal bleeding SO ENDOSCOPY LA English DT Editorial Material C1 [Kwok, R. M.] Walter Reed Army Med Ctr, Dept Med, Gastroenterol Serv, Washington, DC 20307 USA. RP Kwok, RM (reprint author), Walter Reed Army Med Ctr, Dept Med, Gastroenterol Serv, 6900 Georgia Ave, Washington, DC 20307 USA. EM Ryan.Kwok@amedd.army.mil NR 4 TC 1 Z9 1 U1 0 U2 1 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0013-726X J9 ENDOSCOPY JI Endoscopy PD MAR PY 2010 VL 42 SU 2 BP E112 EP E113 DI 10.1055/s-0029-1243943 PG 2 WC Gastroenterology & Hepatology; Surgery SC Gastroenterology & Hepatology; Surgery GA 571MT UT WOS:000275756600030 PM 20306398 ER PT J AU Bluman, EM Ficke, JR Covey, DC AF Bluman, Eric M. Ficke, James R. Covey, Dana C. TI War Wounds of the Foot and Ankle: Causes, Characteristics, and Initial Management SO FOOT AND ANKLE CLINICS LA English DT Article DE Battlefield injuries; Explosive weaponry; Lower extremity injuries; Negative pressure wound therapy ID RED-CROSS; TRAUMATIC AMPUTATION; LEAD-INTOXICATION; BLAST INJURIES; TECHNIQUE TIP; BALLISTICS; CLASSIFICATION; RESUSCITATION; EXPLOSIONS; TERRORISM AB There are many challenges inherent in caring for battlefield injuries to the foot and ankle. Optimal treatment for these injuries continues to change overtime. Newer techniques in the management of massive soft tissue and bony wounds will help to restore the best possible function. These include early damage control surgery, modern limb salvage techniques, and SAWD. The current wars in Iraq and Afghanistan will continue to provide a stimulus for advances in the treatment of high-energy, complex musculoskeletal trauma. C1 [Bluman, Eric M.] Brigham & Womens Hosp, Dept Orthoped, Foot & Ankle Serv, Boston, MA 02115 USA. [Bluman, Eric M.] Harvard Univ, Sch Med, Boston, MA USA. [Ficke, James R.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. [Covey, Dana C.] USN, Med Ctr, Dept Orthopaed Surg, San Diego, CA 92134 USA. RP Bluman, EM (reprint author), Brigham Foot & Ankle Ctr Faulkner, 1153 Ctr St,Suite 56, Boston, MA 02130 USA. EM ebluman@partners.org NR 51 TC 7 Z9 8 U1 2 U2 10 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 1083-7515 J9 FOOT ANKLE CLIN JI Foot Ankle Clin. PD MAR PY 2010 VL 15 IS 1 BP 1 EP 21 DI 10.1016/j.fcl.2009.11.004 PG 21 WC Orthopedics SC Orthopedics GA 745TK UT WOS:000289189200002 PM 20189114 ER PT J AU Bluman, EM Ficke, JR AF Bluman, Eric M. Ficke, James R. TI Traumatic Foot and Ankle Injuries Related to Recent International Conflicts Preface SO FOOT AND ANKLE CLINICS LA English DT Editorial Material C1 [Bluman, Eric M.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Foot & Ankle Serv,Dept Orthoped, Boston, MA 02115 USA. [Ficke, James R.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. RP Bluman, EM (reprint author), Harvard Univ, Sch Med, Brigham & Womens Hosp, Foot & Ankle Serv,Dept Orthoped, 75 Francis St, Boston, MA 02115 USA. EM ebluman@partners.org; james.ficke@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 1083-7515 J9 FOOT ANKLE CLIN JI Foot Ankle Clin. PD MAR PY 2010 VL 15 IS 1 BP XIII EP XIV DI 10.1016/j.fcl.2009.12.001 PG 2 WC Orthopedics SC Orthopedics GA 745TK UT WOS:000289189200001 PM 20189113 ER PT J AU Kragh, JF AF Kragh, John F., Jr. TI Use of Tourniquets and Their Effects on Limb Function in the Modern Combat Environment SO FOOT AND ANKLE CLINICS LA English DT Article DE First aid; Hemorrhage control; Resuscitation; Mass casualties; Disaster ID OPERATION-IRAQI-FREEDOM; DAMAGE CONTROL RESUSCITATION; ENDURING-FREEDOM; CASUALTY CARE; PNEUMATIC TOURNIQUET; HEMORRHAGE CONTROL; TRAUMA; DEATH; INJURY; EXTREMITY AB Tourniquets are lifesaving in emergency care of bleeding casualties by controlling hemorrhage and preventing shock. Modern tourniquets used in combat after widespread fielding and universal training have been consistently associated with improved survival with minor morbidity. C1 USA, Inst Surg Res, Dept Damage Control Resuscitat, Ft Sam Houston, TX 78234 USA. RP Kragh, JF (reprint author), USA, Inst Surg Res, Dept Damage Control Resuscitat, 3400 Rawley E Chambers Ave,Bldg 3611,Room L82-16, Ft Sam Houston, TX 78234 USA. EM john.kragh@amedd.army.mil NR 72 TC 18 Z9 19 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 1083-7515 J9 FOOT ANKLE CLIN JI Foot Ankle Clin. PD MAR PY 2010 VL 15 IS 1 BP 23 EP 40 DI 10.1016/j.fcl.2009.11.001 PG 18 WC Orthopedics SC Orthopedics GA 745TK UT WOS:000289189200003 PM 20189115 ER PT J AU Shawen, SB Keeling, JJ Branstetter, J Kirk, KL Ficke, JR AF Shawen, Scott B. Keeling, John J. Branstetter, Joanna Kirk, Kevin L. Ficke, James R. TI The Mangled Foot and Leg: Salvage Versus Amputation SO FOOT AND ANKLE CLINICS LA English DT Article DE Limb salvage; Amputation; Trauma; Foot; Ankle ID OPEN CALCANEAL FRACTURES; OPERATION ENDURING FREEDOM; OPEN TIBIAL FRACTURES; LIMB SALVAGE; LOWER-EXTREMITY; IRAQI FREEDOM; SURAL FLAP; FOLLOW-UP; RECONSTRUCTION; INJURY AB Treatment of the severely injured lower extremity and mangled foot is fraught with difficulty. Experience has improved the surgeons' ability to salvage limbs, but has not routinely given them the ability to predict which patients will thrive after this choice is made and executed. The authors believe that involving peers and mentors, patient counselors, educating the patients themselves, and comprehensive rehabilitation programs help to prevent patients from losing the desire to improve during the treatment process so that they can eventually return to a productive life. C1 [Shawen, Scott B.] Walter Reed Army Med Ctr, Orthopaed Foot & Ankle Serv, Washington, DC 20307 USA. [Shawen, Scott B.; Keeling, John J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Shawen, Scott B.; Keeling, John J.] Walter Reed Natl Mil Med Ctr, Orthopaed Surg Serv, Bethesda, MD 20889 USA. [Shawen, Scott B.] Natl Capital Consortium, Bethesda, MD USA. [Keeling, John J.] Natl Naval Med Ctr, Orthopaed Surg Serv, Bethesda, MD 20889 USA. [Keeling, John J.] Natl Naval Med Ctr, Orthopaed Foot & Ankle Serv, Bethesda, MD 20889 USA. [Keeling, John J.] Walter Reed Natl Mil Med Ctr, Orthopaed Surg Serv, Washington, DC USA. [Branstetter, Joanna] Madigan Army Med Ctr, Orthopaed Surg Serv, Tacoma, WA 98431 USA. [Kirk, Kevin L.] San Antonio Mil Med Ctr, Integrated Orthoped Surg Serv, San Antonio, TX USA. [Kirk, Kevin L.] Baylor Univ, Sch Grad Studies, Houston, TX 77030 USA. [Ficke, James R.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. RP Shawen, SB (reprint author), Walter Reed Army Med Ctr, Orthopaed Foot & Ankle Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM scott.shawen@us.army.mil NR 28 TC 21 Z9 22 U1 0 U2 5 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 1083-7515 J9 FOOT ANKLE CLIN JI Foot Ankle Clin. PD MAR PY 2010 VL 15 IS 1 BP 63 EP 75 DI 10.1016/j.fcl.2009.11.005 PG 13 WC Orthopedics SC Orthopedics GA 745TK UT WOS:000289189200005 PM 20189117 ER PT J AU Masini, BD Murray, CK Wenke, JC Hsu, JR AF Masini, Brendan D. Murray, Clinton K. Wenke, Joseph C. Hsu, Joseph R. TI Prevention and Treatment of Infected Foot and Ankle Wounds Sustained in the Combat Environment SO FOOT AND ANKLE CLINICS LA English DT Article DE Combat; Trauma; Foot and ankle; Infection ID OPEN TIBIAL FRACTURES; OPERATION ENDURING FREEDOM; PRESSURE PULSATILE LAVAGE; DAMAGE CONTROL ORTHOPEDICS; DELAYED SURGICAL-TREATMENT; OPEN CALCANEAL FRACTURES; OPEN EXTREMITY FRACTURES; FEMORAL-SHAFT FRACTURES; EXTERNAL FIXATION; SOFT-TISSUE AB Open fractures to the foot and ankle are a challenge to manage, especially in a combat environment with high-energy explosive injuries, high contamination rates, challenging environmental constraints, different capabilities of medical care, and varying evacuation procedures and times. The management of these combat wounds has not substantially changed over the last 50 years, with early surgical debridement and stabilization, antibiotic administration, and delayed primary closures. Although the civilian community has tried to advance the understanding of open-fracture care during peace time, there are still many unanswered questions with regard to the optimal management of these casualties. Most of the recommendations for combat-related infections are not supported by good cohort controlled studies, much less randomized control trials. Further efforts need to be made to answer many fundamental questions and establish best treatment strategies. This manuscript addresses the data and recommendations for management of combat-wounded soldiers through the various levels of current military medical care. C1 [Wenke, Joseph C.; Hsu, Joseph R.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Masini, Brendan D.; Murray, Clinton K.; Hsu, Joseph R.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Hsu, JR (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM Joseph.Hsu@amedd.army.mil NR 140 TC 2 Z9 2 U1 1 U2 5 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 1083-7515 J9 FOOT ANKLE CLIN JI Foot Ankle Clin. PD MAR PY 2010 VL 15 IS 1 BP 91 EP 112 DI 10.1016/j.fcl.2009.10.002 PG 22 WC Orthopedics SC Orthopedics GA 745TK UT WOS:000289189200007 PM 20189119 ER PT J AU Baechler, MF Groth, AT Nesti, LJ Martin, BD AF Baechler, Martin F. Groth, Adam T. Nesti, Leon J. Martin, Barry D. TI Soft Tissue Management of War Wounds to the Foot and Ankle SO FOOT AND ANKLE CLINICS LA English DT Article DE War; Foot; Ankle; Flap; Reconstruction; Microsurgery ID OPERATION IRAQI-FREEDOM; THIGH PERFORATOR FLAP; BREVIS MUSCLE FLAP; MICROSURGICAL RECONSTRUCTION; EXTERNAL FIXATION; ENDURING FREEDOM; OPEN FRACTURES; DISTAL LEG; SURAL FLAP; THERAPY AB Reconstruction of the war-wounded foot and ankle is a challenging process requiring endurance, patience, diligence, and many harrowing decisions for the patient and surgeon. These decisions involve reconciling the difficult balance between expectations and feasibility. The reconstructive process does not end with the successful healing of a flap. Indeed, the surgeon must counsel the patient that flap coverage is but one small component of the reconstruction process. Multiple procedures may be necessary before the patient reaches maximum function. Overtime, the patient and the surgeon may consider revisions of a flap to improve shoe wear and weight-bearing of the reconstructed foot and ankle. Also of high importance is the availability of a skilled orthotist for custom fitting of braces and shoe wear in the post-reconstructive period. Ultimately, the patient is the final judge of the outcome of foot and ankle reconstruction. It is not a rare occurrence that the patient and surgeon agree at some point during reconstructive efforts that an amputation is the best option. C1 [Baechler, Martin F.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. [Baechler, Martin F.; Martin, Barry D.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. [Groth, Adam T.] Tripler Army Med Ctr, Dept Surg, Orthopaed Surg Serv, Honolulu, HI 96859 USA. [Nesti, Leon J.] McDonald Army Community Hosp, Dept Surg, Orthopaed Surg Serv, Ft Eustis, VA 23604 USA. [Nesti, Leon J.] NIAMSD, NIH, Bethesda, MD 20892 USA. [Martin, Barry D.] Walter Reed Army Med Ctr, Dept Surg, Integrated Plast Surg Serv, Washington, DC 20307 USA. RP Baechler, MF (reprint author), Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM martin.baechler@us.army.mil RI Groth, Adam/P-9366-2016 OI Groth, Adam/0000-0003-2475-6200 FU NIAAA NIH HHS [F30 AA005516-01, F30 AA005516-02, F30 AA005516-03] NR 67 TC 14 Z9 17 U1 0 U2 5 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 1083-7515 J9 FOOT ANKLE CLIN JI Foot Ankle Clin. PD MAR PY 2010 VL 15 IS 1 BP 113 EP 138 DI 10.1016/j.fcl.2009.10.006 PG 26 WC Orthopedics SC Orthopedics GA 745TK UT WOS:000289189200008 PM 20189120 ER PT J AU Keeling, JJ Hsu, JR Shawen, SB Andersen, RC AF Keeling, John J. Hsu, Joseph R. Shawen, Scott B. Andersen, Romney C. TI Strategies for Managing Massive Defects of the Foot in High-Energy Combat Injuries of the Lower Extremity SO FOOT AND ANKLE CLINICS LA English DT Article DE Open fracture; Calcaneus Fracture; Midfoot fracture; Segmental bone loos; Bone graft ID BLAIR TIBIOTALAR ARTHRODESIS; RING EXTERNAL FIXATION; TALAR NECK FRACTURES; BONE-GRAFT; CALCIUM-SULFATE; ANKLE SURGERY; RECONSTRUCTION; TISSUE; TALUS; METATARSAL AB Bone loss caused by blast-related trauma or secondary infection in the foot and ankle continues to be a difficult problem. The high functional demands required of active service members, also create several reconstructive challenges. Because many of these injured warriors have expectation to return to duty, the demands of service require advanced techniques to obtain adequate outcomes. Even simple uniform requirements affect the service member's perception of his/her reconstruction. Furthermore, occupational requirements such as marching and running on uneven ground require adequate functional motion and a sufficient calcaneal fat pad to tolerate the effect. It is not a stretch to state that the "terminal extremity" drives the success of limb salvage surgery in many of these patients. Moreover, continued research and application of new and improved techniques to address these severe injuries are needed to provide a functional and painless distal extremity in comparison to the high-demand amputee with a well-fitting prosthesis. C1 [Keeling, John J.] Natl Naval Med Ctr, Orthopaed Foot & Ankle Serv, Bethesda, MD 20889 USA. [Keeling, John J.] Natl Naval Med Ctr, Orthopaed Surg Serv, Bethesda, MD 20889 USA. [Keeling, John J.; Shawen, Scott B.; Andersen, Romney C.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Keeling, John J.; Shawen, Scott B.; Andersen, Romney C.] Walter Reed Natl Mil Med Ctr, Orthopaed Surg Serv, Bethesda, MD 20889 USA. [Keeling, John J.; Andersen, Romney C.] Walter Reed Natl Mil Med Ctr, Orthopaed Surg Serv, Washington, DC USA. [Hsu, Joseph R.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Hsu, Joseph R.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Shawen, Scott B.] Walter Reed Army Med Ctr, Orthopaed Foot & Ankle Serv, Washington, DC 20307 USA. [Shawen, Scott B.] Natl Capital Consortium, Bethesda, MD USA. RP Keeling, JJ (reprint author), Natl Naval Med Ctr, Orthopaed Foot & Ankle Serv, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM john.keeling@med.navy.mil NR 41 TC 10 Z9 13 U1 0 U2 6 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 1083-7515 J9 FOOT ANKLE CLIN JI Foot Ankle Clin. PD MAR PY 2010 VL 15 IS 1 BP 139 EP 149 DI 10.1016/j.fcl.2009.10.003 PG 11 WC Orthopedics SC Orthopedics GA 745TK UT WOS:000289189200009 PM 20189121 ER PT J AU Fergason, J Keeling, JJ Bluman, EM AF Fergason, John Keeling, John J. Bluman, Eric M. TI Recent Advances in Lower Extremity Amputations and Prosthetics for the Combat Injured Patient SO FOOT AND ANKLE CLINICS LA English DT Article DE Blast-related extremity trauma; Lower limb amputation; Heterotopic ossification; Prosthetics ID PARTIAL FOOT AMPUTATIONS; TRANS-TIBIAL AMPUTATION; HETEROTOPIC OSSIFICATION; TRANSTIBIAL AMPUTATION; KNEE DISARTICULATION; INTERFACE PRESSURES; ANKLE EXOSKELETONS; SYMES AMPUTATION; SKIN PROBLEMS; AMPUTEES C1 [Fergason, John] Brooke Army Med Ctr, DOR, Ft Sam Houston, TX 78234 USA. [Keeling, John J.] Natl Naval Med Ctr, Orthopaed Surg Serv, Bethesda, MD 20889 USA. [Keeling, John J.] Natl Naval Med Ctr, Orthopaed Foot & Ankle Serv, Bethesda, MD 20889 USA. [Keeling, John J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Keeling, John J.] Walter Reed Natl Mil Med Ctr, Orthopaed Surg Serv, Bethesda, MD 20889 USA. [Keeling, John J.] Walter Reed Natl Mil Med Ctr, Orthopaed Surg Serv, Washington, DC USA. [Bluman, Eric M.] Brigham & Womens Hosp, Dept Orthoped, Boston, MA 02115 USA. [Bluman, Eric M.] Harvard Univ, Sch Med, Boston, MA USA. RP Fergason, J (reprint author), Brooke Army Med Ctr, DOR, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM john.fergason1@amedd.army.mil NR 66 TC 16 Z9 17 U1 1 U2 11 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 1083-7515 J9 FOOT ANKLE CLIN JI Foot Ankle Clin. PD MAR PY 2010 VL 15 IS 1 BP 151 EP 174 DI 10.1016/j.fcl.2009.10.001 PG 24 WC Orthopedics SC Orthopedics GA 745TK UT WOS:000289189200010 PM 20189122 ER PT J AU Owens, JG AF Owens, Johnny G. TI Physical Therapy of the Patient with Foot and Ankle Injuries Sustained in Combat SO FOOT AND ANKLE CLINICS LA English DT Article DE Ankle trauma; Combat injuries; Limb salvage; Rehabilitation ID OPERATION ENDURING FREEDOM; LOWER-EXTREMITY TRAUMA; LOW-BACK-PAIN; IRAQI FREEDOM; MOBILIZATION; FRACTURE; OUTCOMES; IMMOBILIZATION; RECRUITMENT; RESISTANCE AB Foot and ankle injuries sustained in combat pose a challenge to the rehabilitation specialist. Restoring full ROM, strength, and function can be difficult and lasting impairments are common. Current rehabilitative guidelines with this population are limited. Future research in the civilian and military setting is needed to help guide clinical protocols and appropriate outcome measures. C1 Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. RP Owens, JG (reprint author), Brooke Army Med Ctr, Dept Orthopaed & Rehabil, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM johnny.owens@amedd.army.mil NR 26 TC 14 Z9 14 U1 1 U2 2 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 1083-7515 J9 FOOT ANKLE CLIN JI Foot Ankle Clin. PD MAR PY 2010 VL 15 IS 1 BP 175 EP 186 DI 10.1016/j.fcl.2009.10.005 PG 12 WC Orthopedics SC Orthopedics GA 745TK UT WOS:000289189200011 PM 20189123 ER PT J AU Granville, R Menetrez, J AF Granville, Robert Menetrez, Jennifer TI Rehabilitation of the Lower-Extremity War-Injured at the Center for the Intrepid SO FOOT AND ANKLE CLINICS LA English DT Article DE Center for the intrepid; Amputee care; Rehabilitation of the severely wounded; Armed Forces Amputee Care Program; Lower-extremity war-injured ID MANAGEMENT; AMPUTEES AB The Center for the Intrepid (CFI) is a unique facility among the three amputee care centers that comprise the Armed Forces Amputee Care Program. The mission of the CFI is threefold: (1) to provide the best possible patient care to the severely war-wounded, (2) to educate providers in the most advanced methods of rehabilitation for the severely wounded, and (3) to perform research to improve the care of these war-wounded patients. The center's program is based on three critical factors: (1) concentration of similarly injured patients as a cohort, (2) a multidisciplinary approach to patient care, and (3) the concentration of subspecialty skills that ensures the best possible care at an institutional level. The center's active training program benefits professional and ancillary personnel from military community hospitals that may subsequently treat the center's patients as they transition back to duty or retirement. The center's research may ultimately be generalized to amputees of various ages and etiologies, with the goal of returning these patients to productive, fulfilling lives. C1 [Menetrez, Jennifer] Brooke Army Med Ctr, Ctr Intrepid, ATTN MCHE DOR I, Ft Sam Houston, TX 78234 USA. [Granville, Robert] Brooke Army Med Ctr, ATTN MCHE DOR O, Ft Sam Houston, TX 78234 USA. [Menetrez, Jennifer] Brooke Army Med Ctr, Phys Med Serv, Ft Sam Houston, TX 78234 USA. RP Menetrez, J (reprint author), Brooke Army Med Ctr, Ctr Intrepid, ATTN MCHE DOR I, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM jennifer.menetrez@amedd.army.mil FU federal government FX Research is critical to our efforts to identify appropriate evidenced-based surgical and rehabilitation techniques that improve patient outcomes. The majority of our patients elect to enroll in any number of prospective trials currently underway at BAMC and the CFI. The Department of Orthopaedics and Rehabilitation currently has over 90 active protocols. Some of these are being conducted in concert with the Institute of Surgical Research (also located on the BAMC campus) or with external institutions. The CFI has three full-time physical therapists dedicated to research. Each of them holds a doctorate. The Department of Orthopaedics and Rehabilitation employs four full-time research nurses to assist in data collection. Funding is largely derived from the federal government, although some projects have industry support meticulously examined for the ethical nature of the relationships. NR 11 TC 4 Z9 4 U1 0 U2 4 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 1083-7515 J9 FOOT ANKLE CLIN JI Foot Ankle Clin. PD MAR PY 2010 VL 15 IS 1 BP 187 EP 199 DI 10.1016/j.fcl.2009.10.004 PG 13 WC Orthopedics SC Orthopedics GA 745TK UT WOS:000289189200012 PM 20189124 ER PT J AU Rush, JK Kirk, K Kirby, J Hsu, J AF Rush, Jeremy K. Kirk, Kevin Kirby, Jess Hsu, Joseph TI Lateral Talar Dome Access Utilizing Temporary Invasive Distraction SO FOOT & ANKLE INTERNATIONAL LA English DT Article DE Talus; Osteochondral Lesions; Osteochondral Fractures; Temporary Invasive Distraction; Temporary External Fixation ID OSTEOCHONDRAL LESIONS; TRANSCHONDRAL FRACTURES; ANKLE ARTHROSCOPY; SURGICAL APPROACH; TALUS; TRANSPLANTATION; DISSECANS; DEFECTS; OSTEOTOMY; JOINT AB Background: Autogenous osteochondral grafting is an operative option for the treatment of osteochondral lesions of the talus (OLT). Graft implantation often requires an osteotomy to gain perpendicular access to the recipient site. The purpose of this study was to determine the relative contributions of soft tissue releases, osteotomies, and invasive distraction on perpendicular access to the lateral talar dome. We hypothesized that temporary invasive distraction (TID) would provide greater perpendicular access than anterolateral arthrotomy alone and similar access compared to an anterolateral tibial osteotomy. Materials and Methods: Eight fresh frozen cadaveric limb specimens were utilized. An anterolateral arthrotomy was performed and an osteochondral plug was harvested as far posterior as allowed. An additional two Kirschner wires were placed to mark the borders of the area of access. This process was then repeated utilizing: 1) an external fixator for distraction alone, 2) an anterolateral tibial osteotomy alone (with distraction released), and 3) an anterolateral tibial osteotomy (with distraction reapplied). The area accessible as well as the anterior to posterior (AP) access was measured and recorded for each approach. Results: The approach utilizing TID provided greater access than arthrotomy with regard to AP access (p = 0.0007) as well as area (p = 0.003). The approach utilizing TID alone was equivalent to the anterolateral tibial osteotomy with regard to AP access as well as area. TID combined with osteotomy provided greater access than the TID or osteotomy approaches alone with regard to AP access (p = 0.01 and p = 0.02, respectively) and greater access than the external fixator alone with regard to area (p = 0.02). Conclusion: Temporary distraction utilizing external fixation provides greater perpendicular access than anterolateral arthrotomy and access equivalent to anterolateral osteotomy alone. Clinical Relevance: Utilizing TID may obviate the morbidity and possible complications associated with osteotomy and may prove to be a valuable tool in the treatment or osteochondral lesions of the talus. C1 [Rush, Jeremy K.; Kirk, Kevin] Brooke Army Med Ctr, Dept Orthoped & Rehabil, Ft Sam Houston, TX 78234 USA. [Kirby, Jess] USA, Trauma Training Ctr, Ryder Trauma Training Ctr, Miami, FL USA. [Hsu, Joseph] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Rush, JK (reprint author), Brooke Army Med Ctr, Dept Orthoped & Rehabil, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM jeremy.rush@amedd.army.mil NR 30 TC 4 Z9 4 U1 0 U2 0 PU AMER ORTHOPAEDIC FOOT & ANKLE SOC, INC PI SEATTLE PA 2517 EASTLAKE AVE EAST, STE 200, SEATTLE, WA 98102 USA SN 1071-1007 J9 FOOT ANKLE INT JI Foot Ankle Int. PD MAR PY 2010 VL 31 IS 3 BP 236 EP 241 DI 10.3113/FAI.2010.0236 PG 6 WC Orthopedics SC Orthopedics GA 573GC UT WOS:000275895500007 PM 20230702 ER PT J AU Ellefsen, KJ Croize, D Mazzella, AT McKenna, JR AF Ellefsen, Karl J. Croize, Delphine Mazzella, Aldo T. McKenna, Jason R. TI Reply to the discussion on "Frequency-domain Green's functions for radar waves in heterogeneous 2.5D media" (K. J. Ellefsen, D. Croizeacute, A. T. Mazzella, and J. R. McKenna, 2009, GEOPHYSICS, 74, no. 3, J13-J22) SO GEOPHYSICS LA English DT Editorial Material DE electromagnetic waves; finite difference methods; geomagnetism; Green's function methods; terrestrial electricity; wave equations C1 [Ellefsen, Karl J.] US Geol Survey, Denver, CO 80225 USA. [Croize, Delphine] Univ Oslo, Oslo, Norway. [Mazzella, Aldo T.] US EPA, Las Vegas, NV 89193 USA. [McKenna, Jason R.] USA, Engn Res & Dev Ctr, Vicksburg, MS USA. RP Ellefsen, KJ (reprint author), US Geol Survey, Box 25046, Denver, CO 80225 USA. EM ellefsen@usgs.gov; croize@geo.uio.no; mazzella.aldo@epa.gov; Jason.R.McKenna@usace.army.mil NR 2 TC 0 Z9 0 U1 0 U2 0 PU SOC EXPLORATION GEOPHYSICISTS PI TULSA PA 8801 S YALE ST, TULSA, OK 74137 USA SN 0016-8033 J9 GEOPHYSICS JI Geophysics PD MAR-APR PY 2010 VL 75 IS 2 BP X5 EP X5 DI 10.1190/1.3340918 PG 1 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 585YY UT WOS:000276868100035 ER PT J AU Harwell, XS AF Harwell, Xenia Srebrianski TI Beyond Vienna: Contemporary Literature from the Austrian Provinces SO GERMAN QUARTERLY LA English DT Book Review C1 [Harwell, Xenia Srebrianski] US Mil Acad, West Point, NY 10996 USA. RP Harwell, XS (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC TEACHERS GERMAN PI CHERRY HILL PA 112 HADDONTOWNE COURT #104, CHERRY HILL, NJ 08034-3668 USA SN 0016-8831 J9 GER QUART JI Ger. Q. PD SPR PY 2010 VL 83 IS 2 BP 261 EP 262 PG 2 WC Language & Linguistics; Literature, German, Dutch, Scandinavian SC Linguistics; Literature GA 601AX UT WOS:000278031500019 ER PT J AU Weichel, ED Bower, KS Colyer, MH AF Weichel, Eric D. Bower, Kraig S. Colyer, Marcus H. TI Chorioretinectomy for perforating or severe intraocular foreign body injuries SO GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY LA English DT Article DE Ocular trauma; Open globe injury; Intraocular foreign body; Globe perforation; Chorioretinectomy ID PARS-PLANA VITRECTOMY; PENETRATING OCULAR INJURIES; OPERATION IRAQI FREEDOM; POSTERIOR SEGMENT; EYE INJURIES; PROGNOSTIC-FACTORS; LENS IMPLANTATION; PROLIFERATIVE VITREORETINOPATHY; ENDURING FREEDOM; VISUAL OUTCOMES AB To report the outcomes of chorioretinectomy versus non-chorioretinectomy in combat ocular injuries where a foreign body penetrated the choroid or perforated the globe. Retrospective, comparative, consecutive interventional case series of 32 perforating or severe intraocular foreign body combat ocular trauma injuries sustained by United States military soldiers and treated at a single institution from March 2003 to March 2009. Final best-corrected visual acuity (BCVA) in 19 non-chorioretinectomy-treated eyes was compared to 13 chorioretinectomy-treated eyes. The chorioretinectomy group was repaired with a 20 gauge three-port pars plana vitrectomy (PPV) by removing the choroid and/or retina at the impact or perforation site of the foreign body following evacuation from a combat zone. The main outcome measures were best-corrected visual acuity and rates of globe survival, retina reattachment and proliferative vitreoretinopathy. Thirty-two eyes of 31 patients with a mean age of 29 +/- 9 years (range, 19-53 years) were followed for a median of 463 +/- 226 days (range, 59-1022 days). The mean time of injury to the operating room in the chorioretinectomy group was 12.6 +/- 9.8 days, compared to that of the non-chorioretinectomy group of 22.1 +/- 16.4 days (P = 0.05) Final BCVA a parts per thousand yen20/200 occurred in seven of 13 (54%) of the chorioretinectomy group, compared to two of 19 (11%) in the non-chorioretinectomy group (P = 0.04). Globe survival rates were higher in the chorioretinectomy group [11 of 13 (85%) vs 9 of 19 (45%); P = 0.06], as well as the final retinal reattachment rate [8 of 13 (62%) vs 8 of 19 (42%); P = 0.47]. The proliferative vitreoretinopathy rate was eight of 13 (62%) in the chorioretinectomy group, compared to 14 of 19 (74%) in the non-chorioretinectomy group (P = 0.70). Graft failure occurred in five of six eyes (83%) of non-chorioretinectomy cases, requiring temporary keratoprosthesis and penetrating keratoplasty. Chorioretinectomy is a surgical option that may improve final BCVA and increase globe survival rates when a foreign body penetrates the choroid or perforates the globe. C1 [Weichel, Eric D.; Bower, Kraig S.; Colyer, Marcus H.] Walter Reed Army Med Ctr, Ophthalmol Serv, Washington, DC 20307 USA. RP Weichel, ED (reprint author), Walter Reed Army Med Ctr, Ophthalmol Serv, 6900 Georgia Ave, Washington, DC 20307 USA. EM ericweichel@gmail.com NR 72 TC 7 Z9 9 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0721-832X J9 GRAEF ARCH CLIN EXP JI Graefes Arch. Clin. Exp. Ophthalmol. PD MAR PY 2010 VL 248 IS 3 BP 319 EP 330 DI 10.1007/s00417-009-1236-x PG 12 WC Ophthalmology SC Ophthalmology GA 555GP UT WOS:000274497200005 PM 20155279 ER PT J AU Chan, J Cohen, J Shin, J Hamilton, C Chen, L Kapp, D AF Chan, J. Cohen, J. Shin, J. Hamilton, C. Chen, L. Kapp, D. TI Characteristics of SGO plenary presentations that result in subsequent publication in peer-reviewed journals: What factors are responsible? SO GYNECOLOGIC ONCOLOGY LA English DT Meeting Abstract C1 [Chan, J.; Cohen, J.; Shin, J.; Chen, L.] UCSF, Ctr Comprehens Canc, San Francisco, CA USA. [Hamilton, C.] Walter Reed Army Med Ctr, Bethesda, MD USA. [Kapp, D.] Stanford Univ, Sch Med, Stanford, CA 94305 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD MAR PY 2010 VL 116 IS 3 SU 1 MA 392 BP S151 EP S151 PG 1 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 594LA UT WOS:000277538000380 ER PT J AU Miller, C Hamilton, C Farley, J Chernofsky, M Krivak, T Miller, A Brady, M Staney, M Rose, S Maxwell, G AF Miller, C. Hamilton, C. Farley, J. Chernofsky, M. Krivak, T. Miller, A. Brady, M. Staney, M. Rose, S. Maxwell, G. TI The impact of disease distribution on survival in patients with advanced-stage epithelial ovarian cancer cytoreduced to microscopic residual: A Gynecologic Oncology Group study SO GYNECOLOGIC ONCOLOGY LA English DT Meeting Abstract C1 [Miller, C.; Hamilton, C.; Staney, M.; Rose, S.; Maxwell, G.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Farley, J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Chernofsky, M.] Sibley Mem Hosp, Potomac, MD USA. [Krivak, T.] Univ Pittsburgh, Magee Womens Hosp, Sewickley, PA USA. [Miller, A.] Gynecol Oncol Grp, Buffalo, NY USA. [Brady, M.] Roswell Pk Canc Inst, Buffalo, NY 14263 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD MAR PY 2010 VL 116 IS 3 SU 1 MA 35 BP S15 EP S16 PG 2 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 594LA UT WOS:000277538000032 ER PT J AU Risinger, J Chandramouli, G Maxwell, G AF Risinger, J. Chandramouli, G. Maxwell, G. TI Identification of epigenetically downregulated microRNAs in endometrial cancer SO GYNECOLOGIC ONCOLOGY LA English DT Meeting Abstract C1 [Risinger, J.; Chandramouli, G.] Michigan State Univ, Grand Rapids, MI USA. [Maxwell, G.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD MAR PY 2010 VL 116 IS 3 SU 1 MA 195 BP S78 EP S78 PG 1 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 594LA UT WOS:000277538000189 ER PT J AU Doughty, RA AF Doughty, Robert A. TI An Improbable War: The Outbreak of World War I and European Political Culture before 1914 SO HISTORIAN LA English DT Book Review C1 [Doughty, Robert A.] US Mil Acad, West Point, NY 10996 USA. RP Doughty, RA (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0018-2370 J9 HISTORIAN JI Historian PD SPR PY 2010 VL 72 IS 1 BP 204 EP 205 PG 2 WC History SC History GA 564KJ UT WOS:000275212700047 ER PT J AU Boggs, SA Ho, J Jow, TR AF Boggs, Steven A. Ho, Janet Jow, T. Richard TI Overview of Laminar Dielectric Capacitors SO IEEE ELECTRICAL INSULATION MAGAZINE LA English DT Article DE capacitor; laminar dielectric; film dielectric; paper ID FAILURE C1 [Boggs, Steven A.] Univ Connecticut, Elect Insulat Res Ctr, Storrs, CT 06269 USA. [Ho, Janet; Jow, T. Richard] USA, Res Lab, Adelphi, MD USA. RP Boggs, SA (reprint author), Univ Connecticut, Elect Insulat Res Ctr, Storrs, CT 06269 USA. EM janet.ho@arl.army.mil NR 7 TC 6 Z9 6 U1 0 U2 9 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0883-7554 J9 IEEE ELECTR INSUL M JI IEEE Electr. Insul. Mag. PD MAR-APR PY 2010 VL 26 IS 2 BP 7 EP 13 PG 7 WC Engineering, Electrical & Electronic SC Engineering GA 611JK UT WOS:000278811200003 ER PT J AU Jensen, JO Trew, RJ Woolard, DL Gupta, N Theriault, JM Hayat, MM Li, YQ Gillespie, P AF Jensen, James O. Trew, Robert J. Woolard, Dwight L. Gupta, Neelam Theriault, Jean-Marc Hayat, Majeed M. Li, Yanqiu Gillespie, Patti TI Special Issue on Enhancement Algorithms, Methodologies and Technology for Spectral Sensing SO IEEE SENSORS JOURNAL LA English DT Editorial Material C1 [Jensen, James O.] Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 20783 USA. [Trew, Robert J.] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. [Gupta, Neelam] USA, Res Lab, Sensors & Electron Devices Div, Adelphi, MD 20783 USA. [Theriault, Jean-Marc] Def Res & Dev Canada, Valcartier, PQ G3J 1X5, Canada. [Hayat, Majeed M.] Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA. [Li, Yanqiu] Beijing Inst Technol, Beijing 100081, Peoples R China. [Gillespie, Patti] USA, Res Lab, Electroopt & Photon Div, Adelphi, MD 20783 USA. RP Jensen, JO (reprint author), Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 20783 USA. EM jim.jensen@us.army.mil; trew@ncsu.edu; dwight.woolard@us.army.mil; jean-marc.theriault@drdc-rddc.gc.ca; hatat@ece.unm.edu; liyang@mial.iee.ac.cn; patti-gillespie@us.army.mil RI Hayat, Majeed/E-4924-2010 NR 0 TC 0 Z9 0 U1 0 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1530-437X J9 IEEE SENS J JI IEEE Sens. J. PD MAR PY 2010 VL 10 IS 3 BP 373 EP 378 DI 10.1109/JSEN.2010.2041385 PG 6 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA 561RN UT WOS:000274996500001 ER PT J AU Kwan, C Snyder, AP Erickson, RP Smith, PA Maswadeh, WM Ayhan, B Jensen, JL Jensen, JO Tripathi, A AF Kwan, Chiman Snyder, A. Peter Erickson, Richard P. Smith, Philip A. Maswadeh, Waleed M. Ayhan, Bulent Jensen, Janet L. Jensen, James O. Tripathi, Ashish TI Chemical Agent Detection Using GC-IMS: A Comparative Study SO IEEE SENSORS JOURNAL LA English DT Article DE Gas chromatography (GC); ion mobility spectrometry (IMS); image processing; receiver operating characteristic (ROC) ID GAS-CHROMATOGRAPHY AB Low-cost and portable gas chromatography-ion mobility spectrometry (GC-IMS) has been used to identify chemicals. To accomplish this, two parameters are used. The first parameter relates to the GC retention time (RT), which is the residence time of an analyte as it passes through the column. Different chemicals have different RTs. The second parameter is the drift time of ionized species derived for a specific chemical in the IMS. Due to molecular cross section, mass, and chemical properties, different chemicals produce ionized species with different drift times. Combining these two parameters, GC-IMS has been shown to distinguish between different chemicals. Chemical detection and identification are not that easy in practice. First, the concentration of chemicals may be very low, and it may be difficult to determine the chromatographic RT and IMS drift time for chemicals under these conditions. Second, the specific ionized species produced in the IMS are concentration dependent and the IMS spectra obtained at different analyte concentrations are not easily predictable. For example, at low concentrations, chemicals seldom form dimers following atmospheric pressure ionization. The possible presence of either monomers or dimers in the IMS drift tube may confuse the chemical classification process. Third, it is important to estimate the concentration of chemicals, as this information will provide toxicity, and the linear dynamic range of typical IMS systems is relatively low In this study, an image processing approach to enhancing the GC-IMS signal quality is introduced. The key idea in this approach is to treat GC-IMS data as an image and then apply an anomaly detector to detect and enhance abnormal regions in the image. The results of a study that compares a conventional approach to chemical detection and the introduced image enhancement approach are presented. Receiver operating characteristics curves were used to compare the detection performances of the two approaches. C1 [Kwan, Chiman; Ayhan, Bulent] Signal Proc Inc, Rockville, MD 20850 USA. [Maswadeh, Waleed M.] USA, Res Dev & Engn Command, Chem & Biol Point Detect Team, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21040 USA. [Erickson, Richard P.] Naval Submarine Med Res Lab, Submarine Med & Survival Syst Dept, Groton, CT 06349 USA. [Smith, Philip A.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Jensen, Janet L.] USA, Res Dev & Engn Command, Edgewood Chem Biol Ctr, Standoff Detect Team, Aberdeen Proving Ground, MD 21040 USA. [Tripathi, Ashish] Sci Applicat Int Corp, Edgewood, MD 21040 USA. RP Kwan, C (reprint author), Signal Proc Inc, Rockville, MD 20850 USA. EM chiman.kwan@signalpro.net FU Army Research Office [W911NF-08-C-0031] FX Manuscript received August 09, 2008; revised January 14, 2009; accepted January 21, 2009. Current version published February 24, 2010. This work was supported in part by the Army Research Office under Contract W911NF-08-C-0031. The associate editor coordinating the review of this paper and approving it for publication was Dr. James Jensen. NR 11 TC 7 Z9 7 U1 0 U2 24 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1530-437X EI 1558-1748 J9 IEEE SENS J JI IEEE Sens. J. PD MAR PY 2010 VL 10 IS 3 BP 451 EP 460 DI 10.1109/JSEN.2009.2038128 PG 10 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA 561RO UT WOS:000274996600001 ER PT J AU Gupta, N AF Gupta, Neelam TI Spectropolarimetric Imaging of Laser-Induced Fluorescence SO IEEE SENSORS JOURNAL LA English DT Article DE Acoustooptic tunable filter (AOTF); fluorescence spectroscopy; hyperspectral/polarization imager; liquid crystal variable retarder (LCVR) ID TUNABLE FILTERS; POLARIZATION; IMAGER AB A compact wavelength and polarization agile acoustooptic tunable filter (AOTF)-based imager is used to obtain both spectral and polarization signatures from laser-induced fluorescence in a solution for the first time. This imager covers the visible to near-IR region from 400 to 800 nm, with a 10-nm spectral resolution at 600 nm, it uses an electronically tunable TeO(2) AOTF as a bandpass filter, and a nematic liquid crystal variable retarder to change polarization to obtain two orthogonally polarized images at each spectral wavelength. In this experiment, a blocking filter for the laser was not used before the camera. Here we present fluorescence measurement results for a dilute solution of fluorescein in acetone, using a 532-nm laser. Our results showed that for the vertically polarized exciting light, the fluorescence has a spectropolari-metric dependence in agreement with literature. This imager provides a simpler yet powerful tool to facilitate such measurements remotely with ability to extract both spectral and polarization information at each pixel of an extended sample image. C1 USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Gupta, N (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. EM neelam.gupta@us.army.mil RI Gupta, Neelam/B-8702-2013 NR 22 TC 1 Z9 1 U1 3 U2 9 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1530-437X J9 IEEE SENS J JI IEEE Sens. J. PD MAR PY 2010 VL 10 IS 3 BP 503 EP 508 DI 10.1109/JSEN.2009.2038189 PG 6 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA 561RQ UT WOS:000274996800001 ER PT J AU Heinz, DC Davidson, CE Ben-David, A AF Heinz, Daniel C. Davidson, Charles E. Ben-David, Avishai TI Temporal-Spectral Detection in Long-Wave IR Hyperspectral Imagery SO IEEE SENSORS JOURNAL LA English DT Article DE Anomaly; detection; hyperremote sensing; hyperspatial; hyperspectral; hypertemporal; matched; spectral; temporal AB Ground-based staring hyperspectral chemical detectors allow for repeated measurements through time with near-perfect image registration. The problem with standard spectral-based hyperspectral detection algorithms is that they do not make effective use of this temporal information. In this paper, we develop new temporal-spectral detection algorithms, and show that significant improvements in detection performance for staring geometry are achieved by making use of statistical and signal information obtained from previous samples. These new algorithms have the advantage that they limit detection to regions where both temporally and spectrally significant events have occurred. We present the development of these algorithms and demonstrate the performance of both temporal-spectral and spectral-only detectors for detection of gaseous plumes using data from a passive long-wave IR hyperspectral sensor. C1 [Heinz, Daniel C.; Davidson, Charles E.] Sci Technol Corp, Edgewood, MD 21040 USA. [Ben-David, Avishai] USA, Edgewood Chem Biol Ctr, Edgewood, MD 21010 USA. RP Heinz, DC (reprint author), Sci Technol Corp, Edgewood, MD 21040 USA. EM daniel.c.heinz@us.army.mil NR 11 TC 2 Z9 2 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1530-437X J9 IEEE SENS J JI IEEE Sens. J. PD MAR PY 2010 VL 10 IS 3 BP 509 EP 517 DI 10.1109/JSEN.2009.2038624 PG 9 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA 559BS UT WOS:000274795400001 ER PT J AU Xie, Z Bykhovski, A Gelmont, B Globus, T Jensen, JO AF Xie, Zhen Bykhovski, Alexei Gelmont, Boris Globus, Tatiana Jensen, James O. TI Computational Modeling of the Molecular Complex Formed by DIPAIN II and T-2 Toxin SO IEEE SENSORS JOURNAL LA English DT Article DE Biosensing; computational modeling; solid-state detection; trichothecene mycotoxins ID TRICHOTHECENE MYCOTOXINS; CHROMATOGRAPHY AB A fluorescence enhancement in the visible range under UV excitation has been observed in 2-(diphenylacetyl)-l,3indanedione-l-(p-(dimethylamino)benzaldazine) (DIPAIN) II and its derivatives when associating with trichothecene mycotoxins on the solid support. Chromatographic study has shown that it is the molecular complex formed by weak association between DIPAIN II and 12,13-epoxytrichothec-9-ene-3,4,8,15-tetraol 4,15-diacetate 8-(3-methylbutanoate) (T-2) toxin that is directly related to the enhanced fluorescence activity. Previously, a model was proposed by other group to predict a mechanism of the interaction between the molecules in the complex. In this model, five functional groups and regions of DIPAIN II were identified as possible interaction sites with the toxin compounds. More than one area could interact with the compound at the same time. Inspired by these ideas, three mixture conformations of DIPAIN II and T-2 toxin are generated and studied in this paper. The initial geometric structures of two molecules were constructed according to the published papers, and optimization was performed using the Hartree-Fock and the density functional theories followed by calculations of the excited-state energy. The optimization results indicate that there is no chemical bonding between DIPAIN II and T-2 toxin. Nonbonded interactions between T-2 toxin and DIPAIN II could be responsible for the fluorescence enhancement. This conclusion is in agreement with the prediction of the model. The excitation energies are consistent with the experiment results. C1 [Xie, Zhen; Bykhovski, Alexei; Gelmont, Boris; Globus, Tatiana] Univ Virginia, Charlottesville, VA 22904 USA. [Jensen, James O.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 20783 USA. RP Xie, Z (reprint author), Univ Virginia, Charlottesville, VA 22904 USA. EM gb7k@virginia.edu NR 11 TC 0 Z9 0 U1 1 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1530-437X EI 1558-1748 J9 IEEE SENS J JI IEEE Sens. J. PD MAR PY 2010 VL 10 IS 3 BP 541 EP 546 DI 10.1109/JSEN.2009.2037290 PG 6 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA 559BS UT WOS:000274795400005 ER PT J AU Holthoff, EL Heaps, DA Pellegrino, PM AF Holthoff, Ellen L. Heaps, David A. Pellegrino, Paul M. TI Development of a MEMS-Scale Photoacoustic Chemical Sensor Using a Quantum Cascade Laser SO IEEE SENSORS JOURNAL LA English DT Article DE Microelectromechanical system (MEMS); photoacoustic spectroscopy (PAS); quantum cascade laser (QCL); sensor ID TRACE GAS-DETECTION; ACOUSTIC SPECTROSCOPY; MINIATURIZATION; INTEGRATION; CELL AB The development of a microelectromechanical systems-scale photoacoustic chemical sensor is described. Specifically, both a pulsed and a modulated continuous wave quantum cascade laser were used to determine detection limits for dimethyl methylphosphonate (DMMP), a standard nerve gas simulant. These sources were continuously tunable from 9.3 to 10 mu m. We report a minimum detection level of 20 parts-per-billion (ppb) and exceptional agreement between the measured photoacoustic vibrational spectrum and the IR spectrum of DMMP. The results support the continued development of a miniaturized photoacoustic sensor. C1 [Holthoff, Ellen L.; Pellegrino, Paul M.] USA, Res Lab, Adelphi, MD 20783 USA. [Heaps, David A.] Astra Zeneca Pharmaceut LP, Wilmington, DE 19850 USA. RP Holthoff, EL (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM ellen.holthoff@us.army.mil; david.heaps@astrazeneca.com; ppel-legr@arl.army.mil FU U.S. Army Research Laboratory FX Manuscript received August 29, 2008; revised February 27, 2009; accepted March 13, 2009. Current version published February 24, 2010. This work was supported in part by an appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities (OARU) under a contract with the U. S. Army Research Laboratory. The associate editor coordinating the review of this paper and approving it for publication was Dr. James Jensen. NR 32 TC 30 Z9 31 U1 1 U2 14 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1530-437X J9 IEEE SENS J JI IEEE Sens. J. PD MAR PY 2010 VL 10 IS 3 BP 572 EP 577 DI 10.1109/JSEN.2009.2038665 PG 6 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA 561RR UT WOS:000274996900001 ER PT J AU Bykhovski, A Zhao, PJ Woolard, D AF Bykhovski, Alexei Zhao, Peiji Woolard, Dwight TI First Principle Study of the Terahertz and Far-Infrared Spectral Signatures in DNA Bonded to Silicon Nanodots SO IEEE SENSORS JOURNAL LA English DT Article DE Ab initio; DNA; nano; terahertz ID ATOMIC CHARGES AB The first principle study of hydrogen-terminated silicon (111) with deoxyguanosine (dG) residues chemically bonded to a silicon surface via Carbon linkers is performed to reveal new insights into the spectral signatures of constrained DNA chains. Silicon surface structure models are generated to accommodate one or two dG residues. In particular, structural models for two dG residues bonded onto silicon nanodots and that formed a single strand of DNA in the lateral direction (along the surface) were developed. First principle simulations with valence electron basis and effective core potentials are conducted. These studies utilized all-atom geometric optimizations to determine the final conformations and normal mode analyses to derive the spectral absorption information. Stable dG conformations on silicon are obtained for varying types of DNA chain length and Nanodot size/shape. These results show that optically active modes lying within the terahertz spectrum typically arise out of joint coupling between the DNA's vibrational behavior and that of the substrate. However, the dominant absorption line below 6 THz is predicted to most strongly represent the DNA dynamics and effects of sodium, but it is only weakly influenced by the Nanodot vibrations. In this study, the phonon-induced light absorption spectra of the DNA chains were analyzed in the context of nanodot influence (e.g., edge effects). These results suggest that DNA strands can be chemically bonded to arbitrary nanosized features on silicon surfaces without perturbing some of the key spectral signatures in the THz regime, and this suggests active THz illumination strategies for DNA identification and characterization. C1 [Bykhovski, Alexei; Zhao, Peiji; Woolard, Dwight] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. [Woolard, Dwight] USA, Res Off, Div Elect, Res Triangle Pk, NC 27709 USA. RP Bykhovski, A (reprint author), N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. EM abykhov@ncsu.edu; pzhao@unity.ncsu.edu; dwight.woolard@us.army.mil FU National Research Council FX Manuscript received October 16, 2008; revised January 25, 2009; accepted February 06, 2009. Current version published February 24, 2010. This work was supported in part by the National Research Council under Senior Fellowship Program Physics and Modeling of Terahertz Electronic Devices and Nanostructures. The associate editor coordinating the review of this paper and approving it for publication was Dr. James Jensen. NR 13 TC 1 Z9 1 U1 2 U2 11 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1530-437X J9 IEEE SENS J JI IEEE Sens. J. PD MAR PY 2010 VL 10 IS 3 BP 585 EP 598 DI 10.1109/JSEN.2009.2038442 PG 14 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA 561RR UT WOS:000274996900003 ER PT J AU Dhawan, A Du, Y Yan, F Gerhold, MD Misra, V Vo-Dinh, T AF Dhawan, Anuj Du, Yan Yan, Fei Gerhold, Michael D. Misra, Veena Vo-Dinh, Tuan TI Methodologies for Developing Surface-Enhanced Raman Scattering (SERS) Substrates for Detection of Chemical and Biological Molecules SO IEEE SENSORS JOURNAL LA English DT Article DE Annealing; focused ion beam; nanoislands; nanopillars; nanowires; surface-enhanced Raman scattering (SERS); surface plasmons ID PLASMON RESONANCE; NANOPARTICLE ARRAYS; GOLD NANOPARTICLES; SILVER ELECTRODE; SPECTROSCOPY; SPECTRA; SENSOR; GRATINGS AB This paper describes methodologies for developing efficient surface-enhanced Raman scattering (SERS) substrates such as annealing thin gold films for developing gold nanoislands, fabrication of nanopillars arrays and roughened films by employing focused ion beam (FIB) milling of gold films, as well as overcoating deep-UV-fabricated silicon nanowires with a layer of gold film. Excitation of surface plasmons in these gold nanostructures leads to substantial enhancement in the Raman scattering signal obtained from molecules lying in the vicinity of the nanostructure surface. In this paper, we perform comparative studies of SERS signals from molecules such as p-mercaptobenzoic acid and cresyl fast violet attached to or adsorbed on various gold SERS substrates. It was observed that gold-coated silicon nanowire substrates and annealed gold island substrates provided considerably higher SERS signals as compared to those from the FIB patterned substrates and planar gold films. The SERS substrates developed by the different processes were employed for detection of biological molecules such as dipicolinic acid, an excellent marker for spores of bacteria such as Anthrax. C1 [Dhawan, Anuj; Gerhold, Michael D.] USA, Res Off, Durham, NC 27703 USA. [Du, Yan; Misra, Veena] N Carolina State Univ, Raleigh, NC 27695 USA. [Yan, Fei] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA. RP Dhawan, A (reprint author), USA, Res Off, Durham, NC 27703 USA. EM anuj.dhawan@duke.edu; ydu@ncsu.edu; fei.yan@duke.edu; mike.gerhold@us.army.mil; vmisra@ncsu.edu; tuan.vodinh@duke.edu FU U.S. Army Research Office; National Research Council; National Institutes of Health [R01 EB006201, R01 ES014774] FX Manuscript received March 26, 2009; accepted May 24, 2009. Current version published February 24, 2010. This work was supported by the U.S. Army Research Office, National Research Council, and by the National Institutes of Health under Grant R01 EB006201 and Grant R01 ES014774. The associate editor coordinating the review of this paper and approving it for publication was Dr. Dwight Woolard. NR 40 TC 15 Z9 15 U1 2 U2 63 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1530-437X J9 IEEE SENS J JI IEEE Sens. J. PD MAR PY 2010 VL 10 IS 3 BP 608 EP 616 DI 10.1109/JSEN.2009.2038634 PG 9 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA 561RR UT WOS:000274996900006 ER PT J AU Cho, JH Chen, IR Feng, PG AF Cho, Jin-Hee Chen, Ing-Ray Feng, Phu-Gui TI Effect of Intrusion Detection on Reliability of Mission-Oriented Mobile Group Systems in Mobile Ad Hoc Networks SO IEEE TRANSACTIONS ON RELIABILITY LA English DT Article DE Intrusion detection; intrusion detection system; mean time to security failure; mission-oriented group communication systems; mobile ad hoc networks ID SENSOR NETWORKS; WIRELESS NETWORKS; SECURITY; OPTIMIZATION; LIFETIME; MODEL AB For mission-oriented mobile group systems designed to continue mission execution in hostile environments in the presence of security attacks, it is critical to properly deploy intrusion detection techniques to cope with insider attacks to enhance the system reliability. In this paper, we analyze the effect of intrusion detection system (IDS) techniques on the reliability of a mission-oriented group communication system consisting of mobile groups set out for mission execution in mobile ad hoc networks. Unlike the common belief that IDS should be executed as often as possible to cope with insider attacks to prolong the system lifetime, we discover that IDS should be executed at an optimal rate to maximize the mean time to failure of the system. Further, the optimal rate at which IDS is executed depends on the operational conditions, system failure definitions, attacker behaviors, and IDS techniques used. We develop mathematical models based on Stochastic Petri nets to identify the optimal rate for IDS execution to maximize the mean time to failure of the system, when given a set of parameter values characterizing the operational conditions, and attacker behaviors. C1 [Cho, Jin-Hee] USA, Res Lab, Adelphi, MD 20783 USA. [Chen, Ing-Ray] Virginia Tech, Dept Comp Sci, Blacksburg, VA 24061 USA. [Feng, Phu-Gui] Mitre Corp, Bedford, MA 01730 USA. RP Cho, JH (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM jinhee.cho@arl.army.mil; irchen@vt.edu; pfeng@mitre.org NR 31 TC 29 Z9 29 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9529 EI 1558-1721 J9 IEEE T RELIAB JI IEEE Trans. Reliab. PD MAR PY 2010 VL 59 IS 1 BP 231 EP 241 DI 10.1109/TR.2010.2040534 PG 11 WC Computer Science, Hardware & Architecture; Computer Science, Software Engineering; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 608XA UT WOS:000278618100025 ER PT J AU Fan, XC McNeese, M Sun, BJ Hanratty, T Allender, L Yen, J AF Fan, Xiaocong McNeese, Michael Sun, Bingjun Hanratty, Timothy Allender, Laurel Yen, John TI Human-Agent Collaboration for Time-Stressed Multicontext Decision Making SO IEEE TRANSACTIONS ON SYSTEMS MAN AND CYBERNETICS PART A-SYSTEMS AND HUMANS LA English DT Article DE Cognitive agents; context switching; human-centered computing; naturalistic decision making ID TEAMWORK; UNCERTAINTY; MODEL AB Multicontext team decision making under time stress is an extremely challenging issue faced by various real-world application domains. In this paper, we employ an experience-based cognitive agent architecture (called R-CAST) to address the informational challenges associated with military command and control (C(2)) decision-making teams, the performance of which can be significantly affected by dynamic context switching and tasking complexities. Using context switching frequency and task complexity as two factors, we conducted an experiment to evaluate whether the use of R-CAST agents as teammates and decision aids can benefit C(2) decision-making teams. Members from a U. S. Army Reserve Officer Training Corps organization were randomly recruited as human participants. They were grouped into ten human-human teams, each composed of two participants, and ten human-agent teams, each composed of one participant and two R-CAST agents, as teammates and decision aids. The statistical inference of experimental results indicates that R-CAST agents can significantly improve the performance of C(2) teams in multi-context decision making under varying time-stressed situations. C1 [Fan, Xiaocong; McNeese, Michael; Yen, John] Penn State Univ, University Pk, PA 16802 USA. [Sun, Bingjun] Telenav Inc, Sunnyvale, CA 94086 USA. [Hanratty, Timothy; Allender, Laurel] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Fan, XC (reprint author), Penn State Univ, University Pk, PA 16802 USA. EM xfan@psu.edu; mmcneese@ist.psu.edu; sunbingjun@hotmail.com; hanratty@arl.army.mil; lallende@arl.army.mil; jyen@ist.psu.edu FU Army Research Laboratory's Advanced Decision Architectures Collaborative Technology Alliance [FY06] FX Manuscript received March 23, 2007; revised April 10, 2009. First published December 4, 2009; current version published February 18, 2010. This work was supported by the Army Research Laboratory's Advanced Decision Architectures Collaborative Technology Alliance as an FY06 Research Task. This paper was recommended by Editor W. Pedrycz. NR 28 TC 11 Z9 11 U1 0 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1083-4427 J9 IEEE T SYST MAN CY A JI IEEE Trans. Syst. Man Cybern. Paart A-Syst. Hum. PD MAR PY 2010 VL 40 IS 2 BP 306 EP 320 DI 10.1109/TSMCA.2009.2035302 PG 15 WC Computer Science, Cybernetics; Computer Science, Theory & Methods SC Computer Science GA 558IH UT WOS:000274734300008 ER PT J AU Ballato, A AF Ballato, Arthur TI MEMS Fluid Viscosity Sensor SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article; Proceedings Paper CT Joint Meeting of the 23rd European Frequency and Time Forum/IEEE International Frequency Control Symposium CY APR 20-24, 2009 CL Besancon, FRANCE SP Conseil Reg Franche Comte, Ville Besancon, NIST, IEEE, UFFC Soc, Jet Propuls Lab, Symmetricom, OEwaves, Vectron, Conseil Gen Doubs, Communaute Agglomerat Grand Besancon, Univ Franche Comte, Minist Rech & Enseignement Superieur, Soc Francaise Microtech & Chronometrie, Frequency Elect ID QUARTZ-CRYSTAL MICROBALANCE; 30 DEGREES C; GAS MIXTURES; THERMAL CONDUCTIVITY; ACOUSTIC-WAVES; LIQUIDS; MASS; RESONATORS; HELIUM; ARGON AB Quartz shear resonators are employed widely as sensors to measure Newtonian viscosities of liquids. Perturbation of the electrical equivalent circuit parameters of the plate resonator by the fluid loading permits calculation of the mass density-shear viscosity product. Use of doubly rotated resonators does permit additional information to be obtained, but in no case can the viscosity and mass density values be separated. In these measurements, the resonator surface is exposed to a measurand bath whose extent greatly exceeds the penetration depth of the evanescent shear mode excited by the active element. Here we briefly review past techniques and current art, and sketch a proposal involving the interesting situation in which the separation between the resonator and a confining wall is less than the penetration depth of the fluid occupying the intervening region. To highlight the salient features of this novel case, the discussion is limited to the very idealized circumstance of a strictly 1-D problem, unencumbered by the vicissitudes inevitably encountered in practice. An appendix mentions some of these functional impedimenta and indicates how deviations from ideality might be approached in engineering embodiments. When the fluid confinement is of the order of the penetration depth, the resonator perturbation becomes a sensitive function of the separation, and it is found that viscosity and density may be separately and uniquely determined. Moreover, extreme miniaturization is a natural consequence because the penetration depth generally is on the order of micrometers for frequencies around 1 MHz at temperatures and pressures ordinarily encountered with gases and liquids. Micro-electro-mechanical (MEMS) versions of viscometers and associated types of fluid sensors are thereby enabled. C1 USA, Commun Elect RDEC, Ft Monmouth, NJ USA. RP Ballato, A (reprint author), USA, Commun Elect RDEC, Ft Monmouth, NJ USA. EM a.ballato@ieee.org NR 100 TC 4 Z9 4 U1 2 U2 12 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD MAR PY 2010 VL 57 IS 3 BP 669 EP 676 DI 10.1109/TUFFC.2010.1463 PG 8 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA 565VH UT WOS:000275322400024 PM 20211786 ER PT J AU Masrur, MA Chen, Z Murphey, Y AF Masrur, M. Abul Chen, Z. Murphey, Y. TI Intelligent diagnosis of open and short circuit faults in electric drive inverters for real-time applications SO IET POWER ELECTRONICS LA English DT Article ID MODEL-BASED DIAGNOSIS; NEURAL-NETWORKS; MOTOR DRIVE; CLASSIFICATION; SYSTEM AB This study presents a machine learning technique for fault diagnostics in induction motor drives. A normal model and an extensive range of faulted models for the inverter motor combination were developed and implemented using a generic commercial simulation tool to generate voltages and current signals at a broad range of operating points selected by a machine learning algorithm. A structured neural network system has been designed, developed and trained to detect and isolate the most common types of faults: single switch open circuit faults, post short-circuits, short circuits and the unknown faults. Extensive simulation experiments were conducted to test the system with added noise, and the results show that the structured neural network system which was trained by using the proposed machine learning approach gives high accuracy in detecting whether a faulty condition has occurred, thus isolating and pin-pointing to the type of faulty conditions occurring in power electronics inverter-based electrical drives. Finally, the authors show that the proposed structured neural network system has the capability of real-time detection of any of the faulty conditions mentioned above within 20 ms or less. C1 [Masrur, M. Abul] USA, RDECOM TARDEC, Warren, MI 48397 USA. [Chen, Z.; Murphey, Y.] Univ Michigan, Dearborn, MI 48128 USA. RP Masrur, MA (reprint author), USA, RDECOM TARDEC, Warren, MI 48397 USA. EM md.abul.masrur@us.army.mil FU US Army RDECOM-TARDEC ILIR FX The research described in this paper was supported through a funding by the US Army RDECOM-TARDEC ILIR (In-house Lab. Independent Research) program. NR 33 TC 24 Z9 26 U1 0 U2 14 PU INST ENGINEERING TECHNOLOGY-IET PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 1755-4535 J9 IET POWER ELECTRON JI IET Power Electron. PD MAR PY 2010 VL 3 IS 2 BP 279 EP 291 DI 10.1049/iet-pel.2008.0362 PG 13 WC Engineering, Electrical & Electronic SC Engineering GA 582PH UT WOS:000276609400011 ER PT J AU Brennan, L Widder, M van der Schalie, W AF Brennan, Linda Widder, Mark van der Schalie, William TI Comparison of Fish and Mammalian Cell Line Responses to Multiple Chemicals Using Electric Cell-Substrate Impedance Sensing (ECIS) SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL LA English DT Meeting Abstract C1 [Brennan, Linda; Widder, Mark; van der Schalie, William] USA, Ctr Environm Hlth Res, Ft Detrick, MD 21702 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1071-2690 J9 IN VITRO CELL DEV-AN JI In Vitro Cell. Dev. Biol.-Anim. PD SPR PY 2010 VL 46 SU S BP S101 EP S101 PG 1 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA 695JX UT WOS:000285367500224 ER PT J AU Finer, J Bouchard, R Chen, XF Rushton, P AF Finer, John Bouchard, Robert Chen Xianfeng Rushton, Paul TI Isolation and Validation of Soybean Promoter Families SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL LA English DT Meeting Abstract C1 [Finer, John; Bouchard, Robert] Ohio State Univ, Wooster, OH 44691 USA. [Chen Xianfeng] USA, Environm Lab, Engn Res & Dev Ctr, Corps Engineers, Vicksburg, MS 39180 USA. [Rushton, Paul] S Dakota State Univ, Brookings, SD 57007 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1071-2690 J9 IN VITRO CELL DEV-AN JI In Vitro Cell. Dev. Biol.-Anim. PD SPR PY 2010 VL 46 SU S BP S25 EP S25 PG 1 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA 695JX UT WOS:000285367500056 ER PT J AU McNutt, P AF McNutt, Patricky TI Development and Application of Embryonic Stem Cell-derived Neurons for Botulinum Neurotoxin Research SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL LA English DT Meeting Abstract C1 [McNutt, Patricky] USAMRICD, Aberdeen Proving Ground, MD 21010 USA. [McNutt, Patricky] US Army, ATTN MAJ, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1071-2690 J9 IN VITRO CELL DEV-AN JI In Vitro Cell. Dev. Biol.-Anim. PD SPR PY 2010 VL 46 SU S BP S47 EP S47 PG 1 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA 695JX UT WOS:000285367500105 ER PT J AU Miller, A Gross, C Nealley, E Clark, O Waraich, N Rodgers, K Smith, W AF Miller, Adele Gross, Clark Nealley, Eric Clark, Offie Waraich, Narinder Rodgers, Kelly Smith, William TI Use of H2AX and Micronuclei Formation to Evaluate Genotoxicity in Cultured Human Skin Cells Following Sulfur Mustard Exposure SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL LA English DT Meeting Abstract C1 [Miller, Adele; Gross, Clark; Nealley, Eric; Clark, Offie; Waraich, Narinder; Rodgers, Kelly; Smith, William] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1071-2690 J9 IN VITRO CELL DEV-AN JI In Vitro Cell. Dev. Biol.-Anim. PD SPR PY 2010 VL 46 SU S BP S142 EP S142 PG 1 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA 695JX UT WOS:000285367500318 ER PT J AU Nealley, E Nipwoda, T Gross, C Clark, O Miller, A Smith, W AF Nealley, Eric Nipwoda, Theresa Gross, Clark Clark, Offie Miller, Adele Smith, William TI Operation of a Cell Culture Core Laboratory to Provide Human Cell and Tissue Models used in the Study of Chemical Warfare Agents SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL LA English DT Meeting Abstract C1 [Smith, William] USA, Med Res Inst Chem Def, USAMRICD, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1071-2690 J9 IN VITRO CELL DEV-AN JI In Vitro Cell. Dev. Biol.-Anim. PD SPR PY 2010 VL 46 SU S BP S74 EP S74 PG 1 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA 695JX UT WOS:000285367500163 ER PT J AU Rastogi, V Wallace, L Ryan, S Shah, S AF Rastogi, Vipin Wallace, Lalena Ryan, Shawn Shah, Saumil TI Development of a Novel Bioassay for Detection of Functional Ricin SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL LA English DT Meeting Abstract C1 [Rastogi, Vipin; Wallace, Lalena; Ryan, Shawn; Shah, Saumil] USA, Edgewood Chem & Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1071-2690 J9 IN VITRO CELL DEV-AN JI In Vitro Cell. Dev. Biol.-Anim. PD SPR PY 2010 VL 46 SU S BP S62 EP S62 PG 1 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA 695JX UT WOS:000285367500138 ER PT J AU Widder, M Brennan, L van der Schalie, W AF Widder, Mark Brennan, Linda van der Schalie, William TI A Portable Impedance-Based Biosensor and Automated Cell Maintenance System for Water Toxicity Testing SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL LA English DT Meeting Abstract C1 [Widder, Mark; Brennan, Linda; van der Schalie, William] USA, Ctr Environm Hlth Res, Ft Detrick, MD 21702 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1071-2690 J9 IN VITRO CELL DEV-AN JI In Vitro Cell. Dev. Biol.-Anim. PD SPR PY 2010 VL 46 SU S BP S84 EP S84 PG 1 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA 695JX UT WOS:000285367500186 ER PT J AU Straight, TM Merrill, G Perez, L Livezey, J Robinson, B Lodes, M Suciu, D Anderson, B AF Straight, T. M. Merrill, G. Perez, L. Livezey, J. Robinson, B. Lodes, M. Suciu, D. Anderson, B. TI A novel electrochemical device to differentiate pandemic (H1N1) 2009 from seasonal influenza SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Article DE CombiMatrix; electrochemical; influenza; pandemic (H1N1) 2009; swine flu ID A H1N1; SUBTYPE; ASSAYS AB Background One of the challenges of the recent pandemic (H1N1) 2009 influenza outbreak was to differentiate the virus from seasonal influenza when confronting clinical cases. The determination of the virus has implications on treatment choice, and obvious epidemiologic significance. Objectives We set out to apply a novel electrochemical device to samples derived from clinical cases of pandemic (H1N1) 2009 influenza to examine the ability of the device to differentiate these samples from cases of seasonal influenza. Patients/Methods An IRB approved protocol allowed for the use of original nasal wash samples from 24 confirmed human cases pandemic (H1N1) 2009 influenza. Clinical samples from cases of seasonal influenza (Influenza A/H1N1, A/H3N2, and B) were included as controls. Nucleic acids were extracted and samples examined by the ElectraSense (R) Influenza A assay (CombiMatrix, Inc). Samples were also examined by RT-PCR or Luminex assays as a comparator. Results and Conclusions The ElectraSense (R) Influenza A assay correctly identified 23 of 24 samples of laboratory-confirmed pandemic (H1N1) 2009 Influenza. The assay correctly identified all samples of influenza A/H1N1 and A/H3N2, and differentiated these from pandemic (H1N1) 2009 Influenza in all cases. The ElectraSense (R) Influenza A assay proved to be a useful assay to quickly and accurately differentiate pandemic (H1N1) 2009 influenza from seasonal influenza. C1 [Straight, T. M.; Merrill, G.; Perez, L.] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. [Lodes, M.; Suciu, D.; Anderson, B.] CombiMatrix Corp, Mukilteo, WA USA. RP Straight, TM (reprint author), Brooke Army Med Ctr, Dept Clin Invest, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM timothy.m.straight@us.army.mil NR 13 TC 5 Z9 5 U1 1 U2 13 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1750-2640 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD MAR PY 2010 VL 4 IS 2 BP 73 EP 79 DI 10.1111/j.1750-2659.2009.00123.x PG 7 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA 554BR UT WOS:000274411000004 PM 20167047 ER PT J AU St Leger, A Nwankpa, C AF St Leger, Aaron Nwankpa, Chika TI OTA-based transmission line model with variable parameters for analog power flow computation SO INTERNATIONAL JOURNAL OF CIRCUIT THEORY AND APPLICATIONS LA English DT Article DE analog computation; power flow; power system emulation; transmission line model ID INPUT STAGE; SIMULATION; LINEARIZATION AB Analog computation has some inherent benefits over traditional digital computation methods and fosters a continued interest in research, specifically in power systems, due to its associated strengths. Among these advantages are physically realizable solutions, much faster computation times and more accurate models. To realize an analog computation environment for power system analysis analog models and their circuit realizations are required. This paper focuses on the design, simulation and hardware verification of transmission line models with variable parameters for the purpose of analog power flow computation. Specifically, pi equivalent lumped parameter and distributed parameter transmission line models with parametric variation based on temperature and frequency are presented. Operational transconductance amplifiers (OTAs) are the primary circuit elements in the hardware designs and allow remote reconfigurability and variation of transmission line parameters via transconductance gain. Test results are presented from a hardware prototype, which was developed and tested based on the proposed analog line models. Copyright (C) 2008 John Wiley & Sons, Ltd. C1 [Nwankpa, Chika] Drexel Univ, Dept Elect & Comp Engn, Ctr Elect Power Engn, Philadelphia, PA 19104 USA. [St Leger, Aaron] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. RP Nwankpa, C (reprint author), Drexel Univ, Dept Elect & Comp Engn, Ctr Elect Power Engn, Philadelphia, PA 19104 USA. EM nwankpa@ece.drexel.edu FU U.S. Department of Energy [CH11170]; National Science Foundation [ECS-0601647] FX Contract/grant sponsor: U.S. Department of Energy; contract/grant number: CH11170; Contract/grant sponsor: National Science Foundation; contract/grant number: ECS-0601647 NR 35 TC 1 Z9 1 U1 1 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0098-9886 EI 1097-007X J9 INT J CIRC THEOR APP JI Int. J. Circuit Theory Appl. PD MAR PY 2010 VL 38 IS 2 BP 199 EP 220 DI 10.1002/cta.555 PG 22 WC Engineering, Electrical & Electronic SC Engineering GA 570SX UT WOS:000275699400006 ER PT J AU Fadare, O Bonvicino, A Martel, M Renshaw, IL Azodi, M Parkash, V AF Fadare, Oluwole Bonvicino, Amanda Martel, Maritza Renshaw, Idris L. Azodi, Masoud Parkash, Vinita TI Pleomorphic Rhabdomyosarcoma of the Uterine Corpus: A Clinicopathologic Study of 4 Cases and a Review of the Literature SO INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY LA English DT Review DE Rhabdomyosarcoma; Pleomorphic; Uterus; Myo-D1 ID MALIGNANT RHABDOID TUMOR; ENDOMETRIAL STROMAL SARCOMA; FEMALE GENITAL-TRACT; PURE EMBRYONAL RHABDOMYOSARCOMA; ALVEOLAR RHABDOMYOSARCOMA; EPITHELIOID LEIOMYOSARCOMA; POSTMENOPAUSAL PATIENT; FALLOPIAN-TUBE; UTERUS; ADULTS AB We report the clinicopathologic features of 4 cases of pure pleomorphic rhabdomyosarcoma of the uterine corpus with an emphasis on their frequent expression of CD10 and CD56, review the relevant literature, and discuss differential diagnostic considerations. The patients ranged from 51 to 79 years (mean 68 y). All were FIGO stage IIIC to IV at initial surgical staging, and 3 were dead from the disease at an average of 8.6 months follow-up. In addition to the expected findings, other notable morphologic features included tumor giant cells (4/4), osteoclast-like giant cells (1/4), patchy myxoid stroma (4/4), and only infrequent cytoplasmic cross striations (1/4). The tumors in all 4 cases were positive for myogenin, myo-D1, smooth muscle actin, desmin, muscle-specific actin (HHF-35), and CD10; 3 (75%) of 4 cases were positive for calponin and CD56; all cases were negative for cytokeratin 7, synaptophysin, epithelial membrane antigen, placental-like alkaline phosphatase, chromogranin, and a pan-keratin. Twenty-three cases have been reported earlier in the English-language literature between 1969 and 2009. In combination with the current 4, the 27 patients had an age range of 35 to 87 years (mean 66.33 y). Only 1 patient was deemed inoperable; most had staging operations. Following their initial evaluations, 16 (59%) were found to have extrauterine extension of disease. At follow-up, 73% (19/27) were dead from the disease and 19.2% had no evidence of recurrence. Ten (53%) of the 19 deaths occurred within 6.5 months of initial evaluation. Stage at presentation did not have any significant impact on outcome: 73% of the 11 patients with uterus-confined disease at presentation were dead from the disease at follow-up, a rate of disease-associated death that was nearly identical to the 75% in the 16 patients with extrauterine disease at presentation. A wide variety of neoadjuvant and adjuvant therapies were administered, which did not appear to significantly impact outcomes. These data indicate that pleomorphic rhabdomyosarcoma of the uterine corpus is a highly aggressive, rapidly progressive tumor with a high case-fatality rate. C1 [Fadare, Oluwole; Bonvicino, Amanda] Wilford Hall USAF Med Ctr, Dept Pathol, Lackland AFB, TX USA. [Bonvicino, Amanda] San Antonio Uniformed Serv Hlth Educ Consortium, Pathol Program, San Antonio, TX USA. [Bonvicino, Amanda] Brooke Army Med Ctr, Dept Pathol & Lab Serv, Ft Sam Houston, TX 78234 USA. [Renshaw, Idris L.] Vanguard Pathol Associates, Austin, TX USA. [Fadare, Oluwole] Vanderbilt Univ, Med Ctr, Dept Pathol, Nashville, TN 37332 USA. [Martel, Maritza] Yale New Haven Med Ctr, Dept Pathol, New Haven, CT 06504 USA. [Martel, Maritza] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA. [Martel, Maritza; Azodi, Masoud; Parkash, Vinita] Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, New Haven, CT USA. [Parkash, Vinita] Bridgeport Hosp, Dept Pathol, Bridgeport, CT USA. [Martel, Maritza] Providence Hlth & Serv, Portland, OR USA. RP Fadare, O (reprint author), Vanderbilt Univ, Med Ctr, Dept Pathol, 1161 21st Ave S,MCN Rm C-2310D, Nashville, TN 37332 USA. EM oluwolefadare@yahoo.com NR 82 TC 12 Z9 14 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0277-1691 J9 INT J GYNECOL PATHOL JI Int. J. Gynecol. Pathol. PD MAR PY 2010 VL 29 IS 2 BP 122 EP 134 DI 10.1097/PGP.0b013e3181bc98c0 PG 13 WC Obstetrics & Gynecology; Pathology SC Obstetrics & Gynecology; Pathology GA 586KN UT WOS:000276907200005 PM 20173498 ER PT J AU Jarman, R Myint, KSA Shrestha, S Gaywee, J Velasco, JM Yoon, IK Saunders, D Timmermans, A Ungchusak, K Wongstitwilairoong, T Mason, CJ Gibbons, RV Pavlin, JA AF Jarman, R. Myint, K. S. A. Shrestha, S. Gaywee, J. Velasco, J. M. Yoon, I. -K Saunders, D. Timmermans, A. Ungchusak, K. Wongstitwilairoong, T. Mason, C. J. Gibbons, R. V. Pavlin, J. A. TI Influenza surveillance contributions from South and Southeast Asia SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Meeting Abstract C1 [Jarman, R.; Myint, K. S. A.; Shrestha, S.; Gaywee, J.; Velasco, J. M.; Yoon, I. -K; Saunders, D.; Timmermans, A.; Wongstitwilairoong, T.; Mason, C. J.; Gibbons, R. V.; Pavlin, J. A.] Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Ungchusak, K.] Minist Publ Hlth, Bangkok, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD MAR PY 2010 VL 14 SU 1 BP E322 EP E323 DI 10.1016/j.ijid.2010.02.2206 PG 2 WC Infectious Diseases SC Infectious Diseases GA 578MQ UT WOS:000276298201293 ER PT J AU Magill, A AF Magill, A. TI Choice of Drugs for the Prophylaxis of Malaria in the Americas SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Meeting Abstract C1 [Magill, A.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD MAR PY 2010 VL 14 SU 1 BP E23 EP E23 DI 10.1016/j.ijid.2010.02.1538 PG 1 WC Infectious Diseases SC Infectious Diseases GA 578MQ UT WOS:000276298200060 ER PT J AU Naraghi-Arani, P Bavari, S Gardner, S Jaing, C Thissen, J AF Naraghi-Arani, P. Bavari, S. Gardner, S. Jaing, C. Thissen, J. TI Identification of novel microRNA biomarkers of viral infection SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Meeting Abstract C1 [Naraghi-Arani, P.; Gardner, S.; Jaing, C.; Thissen, J.] Lawrence Livermore Natl Lab, Livermore, CA USA. [Bavari, S.] USA, Med Res Inst Infect Dis, Frederick, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD MAR PY 2010 VL 14 SU 1 BP E364 EP E364 DI 10.1016/j.ijid.2010.02.431 PG 1 WC Infectious Diseases SC Infectious Diseases GA 578MQ UT WOS:000276298201391 ER PT J AU Gupta, N Cho, K AF Gupta, Nikhil Cho, Kyu TI Symposium preview: High strain rate behaviors of composites and heterogeneous materials SO JOM LA English DT Article C1 [Gupta, Nikhil] NYU, Polytech Inst, Dept Mech & Aerosp Engn, Brooklyn, NY 11201 USA. [Cho, Kyu] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Gupta, N (reprint author), NYU, Polytech Inst, Dept Mech & Aerosp Engn, Brooklyn, NY 11201 USA. EM ngupta@poly.edu; kcho@arl.army.mil RI Gupta, Nikhil/F-8094-2012 NR 7 TC 0 Z9 0 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1047-4838 J9 JOM-US JI JOM PD MAR PY 2010 VL 62 IS 3 BP 25 EP 26 DI 10.1007/s11837-010-0044-4 PG 2 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing SC Materials Science; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing GA 571YI UT WOS:000275792000006 ER PT J AU Ramasamy, M Wilson, JS Martins, PB AF Ramasamy, Manikandan Wilson, Jacob S. Martins, Preston B. TI Interaction of Synthetic Jet with Boundary Layer Using Microscopic Particle Image Velocimetry SO JOURNAL OF AIRCRAFT LA English DT Article ID CROSS-FLOW; PIV; ROTOR; VALIDATION AB The aerodynamic interaction between an unsteady, inclined synthetic jet and a crossflow boundary layer was studied as a precursor toward applying active flow control concepts for rotor applications, such as dynamic stall control and fuselage drag reduction. Because the flowfield offered numerous challenges from a measurement perspective, several experiments were carried out using a phase-locked, two-dimensional microscopic particle image velocity technique in a building block approach, by adding one complexity after another. The procedure began with boundary layer measurements made on a simple flat plate using the microscopic particle image velocity technique. Velocity measurements were made deep in the viscous sublayer, as close as 20 mu m from the surface. Following this, the synthetic jet actuator was characterized while operating in quiescent air as well as in crossflow. The results showed that the evolution of the synthetic jet in crossflow was substantially different from its evolution in quiescent air, suggesting that any flow physics or performance prediction (for example, the depth of penetration of the jet into the boundary layer) made based on the quiescent flow conditions may not be applicable in crossflow. All the momentum added to the boundary layer had its source from the synthetic jet actuator, and the penetration of the jet was limited to the viscous sublayer and log layer; the outer layer was unaffected, despite using a jet to freestream velocity ratio of four. Significant effort was also made to validate the microscopic particle image velocity technique and evaluate its capability to accurately resolve such a complex flowfield. To this end, microscopic particle image velocity measurements were compared with hot-wire measurements made on a simple steady jet, as well as an unsteady, periodic synthetic jet. Excellent correlation was found between the two techniques, validating microscopic particle image velocity measurements. C1 [Ramasamy, Manikandan] Univ Calif Santa Cruz, Santa Cruz, CA 95064 USA. [Wilson, Jacob S.; Martins, Preston B.] NASA, Langley Res Ctr, Hampton, VA 23681 USA. [Martins, Preston B.] USA, Aeroflightdynam Directorate, Res Dev & Engn Command, Joint Res Program Off, Washington, DC USA. [Ramasamy, Manikandan] NASA, Ames Res Ctr, Moffett Field, CA 94035 USA. RP Ramasamy, M (reprint author), NASA, Ames Res Ctr, Moffett Field, CA 94035 USA. EM mani.ramasamy@us.army.mil; jacob.s.wilson@us.army.mil; preston.b.martin@us.army.mil NR 42 TC 7 Z9 7 U1 0 U2 10 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0021-8669 J9 J AIRCRAFT JI J. Aircr. PD MAR-APR PY 2010 VL 47 IS 2 BP 404 EP 422 DI 10.2514/1.45794 PG 19 WC Engineering, Aerospace SC Engineering GA 581ZT UT WOS:000276565300005 ER PT J AU Waibel, KH Gomez, R AF Waibel, Kirk H. Gomez, Robert TI Ovalbumin content in 2009 to 2010 seasonal and H1N1 monovalent influenza vaccines SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Letter ID EGG ALLERGY; VACCINATION C1 [Waibel, Kirk H.] Brooke Army Med Ctr, Dept Med, Allergy Immunol Serv, Ft Sam Houston, TX 78234 USA. [Gomez, Robert] Wilford Hall USAF Med Ctr, Allergy Immunol Clin, Dept Med, Lackland AFB, TX USA. RP Waibel, KH (reprint author), Brooke Army Med Ctr, Dept Med, Allergy Immunol Serv, Ft Sam Houston, TX 78234 USA. EM kirk.waibel@amedd.army.mil NR 9 TC 25 Z9 26 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD MAR PY 2010 VL 125 IS 3 BP 749 EP 751 DI 10.1016/j.jaci.2009.12.015 PG 3 WC Allergy; Immunology SC Allergy; Immunology GA 573BK UT WOS:000275883200037 PM 20060576 ER PT J AU Brodhead, MJ AF Brodhead, Michael J. TI Class and Race in the Frontier Army: Military Life in the West, 1870-1890 SO JOURNAL OF AMERICAN HISTORY LA English DT Book Review C1 [Brodhead, Michael J.] US Army Corps Engineers, Off Hist, Alexandria, VA USA. RP Brodhead, MJ (reprint author), US Army Corps Engineers, Off Hist, Alexandria, VA USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ORGANIZATION AMER HISTORIANS PI BLOOMINGTON PA 112 N BRYAN ST, BLOOMINGTON, IN 47408 USA SN 0021-8723 J9 J AM HIST JI J. Am. Hist. PD MAR PY 2010 VL 96 IS 4 BP 1189 EP 1190 PG 2 WC History SC History GA 579ZO UT WOS:000276416200066 ER PT J AU Ignaccolo, M Latka, M Jernajczyk, W Grigolini, P West, BJ AF Ignaccolo, Massimiliano Latka, Mirek Jernajczyk, Wojciech Grigolini, Paolo West, Bruce J. TI The dynamics of EEG entropy SO JOURNAL OF BIOLOGICAL PHYSICS LA English DT Article DE EEG; Entropy; Statistical analysis ID RANGE TEMPORAL CORRELATIONS; TEEN BIRTH PHENOMENON; MATHEMATICAL-THEORY; SCALING BEHAVIOR; TIME-SERIES; BRAIN; ELECTROENCEPHALOGRAM; COMMUNICATION; FLUCTUATIONS; OSCILLATIONS AB The scaling properties of human EEG have so far been analyzed predominantly in the framework of detrended fluctuation analysis (DFA). In particular, these studies suggested the existence of power-law correlations in EEG. In DFA, EEG time series are tacitly assumed to be made up of fluctuations, whose scaling behavior reflects neurophysiologically important information and polynomial trends. Even though these trends are physiologically irrelevant, they must be eliminated (detrended) to reliably estimate such measures as Hurst exponent or fractal dimension. Here, we employ the diffusion entropy method to study the scaling behavior of EEG. Unlike DFA, this method does not rely on the assumption of trends superposed on EEG fluctuations. We find that the growth of diffusion entropy of EEG increments of awake subjects with closed eyes is arrested only after approximately 0.5 s. We demonstrate that the salient features of diffusion entropy dynamics of EEG, such as the existence of short-term scaling, asymptotic saturation, and alpha wave modulation, may be faithfully reproduced using a dissipative, first-order, stochastic differential equation-an extension of the Langevin equation. The structure of such a model is utterly different from the "noise+trend" paradigm of DFA. Consequently, we argue that the existence of scaling properties for EEG dynamics is an open question that necessitates further studies. C1 [Ignaccolo, Massimiliano] Duke Univ, Dept Phys, Durham, NC 27706 USA. [Latka, Mirek] Wroclaw Univ Technol, Inst Biomed Engn, PL-50370 Wroclaw, Poland. [Jernajczyk, Wojciech] Inst Psychiat & Neurol, Dept Clin Neurophysiol, Warsaw, Poland. [Grigolini, Paolo] Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA. [West, Bruce J.] USA, Math & Informat Sci Directorate, Res Off, Durham, NC USA. RP Ignaccolo, M (reprint author), Duke Univ, Dept Phys, Durham, NC 27706 USA. EM mi8@phy.duke.edu NR 29 TC 12 Z9 12 U1 2 U2 9 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0092-0606 J9 J BIOL PHYS JI J. Biol. Phys. PD MAR PY 2010 VL 36 IS 2 BP 185 EP 196 DI 10.1007/s10867-009-9171-y PG 12 WC Biophysics SC Biophysics GA 558AI UT WOS:000274711900006 PM 19669909 ER PT J AU Zacchilli, MA Owens, BD AF Zacchilli, Michael A. Owens, Brett D. TI Epidemiology of Shoulder Dislocations Presenting to Emergency Departments in the United States SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Article ID INJURIES; CHILDREN AB Background: The epidemiology of traumatic shoulder dislocations is poorly understood. The aim of the current study was to determine the incidence of shoulder dislocations presenting to hospital emergency departments in the United States and define demographic risk factors for these injuries. Methods: The National Electronic Injury Surveillance System, a probability sample of all injuries presenting to emergency departments in the United States, was queried for shoulder dislocations from 2002 through 2006. Patient and injury characteristics were analyzed. United States Census data were utilized to calculate incidence rates for the United States population and subgroups. Incidence rate ratios were then calculated with respect to age, sex, and race. Results: A total of 8940 shoulder dislocations were identified, resulting in an overall incidence rate in the United States of 23.9 (95% confidence interval, 20.8 to 27.0) per 100,000 person-years. The male incidence rate was 34.90 (95% confidence interval, 30.08 to 39.73) per 100,000 person-years, with an incidence rate ratio of 2.64 (95% confidence interval, 2.39 to 2.88) relative to the female incidence rate. It was found that 71.8% of the dislocations were in males. Stratified by decade, the maximum incidence rate (47.8 [95% confidence interval, 41.0 to 54.5]) occurred in those between the ages of twenty and twenty-nine years; 46.8% of all dislocations were in patients between fifteen and twenty-nine years of age. There were no significant differences based on race. Dislocations most frequently resulted from a fall (58.8%) and occurred at home (47.7%) or at sites of sports or recreation (34.5%). Overall, 48.3% of injuries occurred during sports or recreation. Conclusions: The estimated incidence rate of shoulder dislocations in the United States is 23.9 per 100,000 person-years, which is approximately twice the previously reported value. A young age and male sex are risk factors for shoulder dislocation in the United States population. C1 [Zacchilli, Michael A.; Owens, Brett D.] William Beaumont Army Med Ctr, El Paso, TX 79920 USA. RP Zacchilli, MA (reprint author), Keller Army Community Hosp, 900 Washington Rd, West Point, NY 10996 USA. EM b.owens@us.army.mil NR 18 TC 95 Z9 97 U1 0 U2 10 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 USA SN 0021-9355 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD MAR PY 2010 VL 92A IS 3 BP 542 EP 549 DI 10.2106/JBJS.I.00450 PG 8 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 564KT UT WOS:000275213800003 PM 20194311 ER PT J AU Duran-Stanton, AM Bui-Mansfield, LT AF Duran-Stanton, Amelia M. Bui-Mansfield, Liem T. TI Magnetic Resonance Diagnosis of Tarsal Tunnel Syndrome Due to Flexor Digitorum Accessorius Longus and Peroneocalcaneus Internus Muscles SO JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY LA English DT Article DE tarsal tunnel syndrome; anomalous or accessory muscles of the ankle; MR imaging ID SKELETAL-MUSCLE; MR AB Anomalous muscles of the ankle are common. Although they are often asymptomatic, they can sometimes cause tarsal tunnel syndrome. We report a case of tarsal tunnel syndrome due to flexor digitorum accessorius longus and peroneocalcaneus internus muscles diagnosed on magnetic resonance imaging. Recognition of the most common accessory muscles of the ankle on magnetic resonance imaging and tarsal tunnel syndrome are also reviewed. C1 [Bui-Mansfield, Liem T.] USUHS, Dept Radiol, Bethesda, MD 20814 USA. [Duran-Stanton, Amelia M.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, San Antonio, TX USA. [Bui-Mansfield, Liem T.] Brooke Army Med Ctr, Dept Radiol, San Antonio, TX USA. RP Bui-Mansfield, LT (reprint author), USUHS, Dept Radiol, Bethesda, MD 20814 USA. EM liem.mansfield@gmail.com NR 16 TC 8 Z9 8 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0363-8715 J9 J COMPUT ASSIST TOMO JI J. Comput. Assist. Tomogr. PD MAR-APR PY 2010 VL 34 IS 2 BP 270 EP 272 DI 10.1097/RCT.0b013e3181ca7ab8 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 581BS UT WOS:000276496600023 PM 20351519 ER PT J AU Henning, MJS Firoz, BF AF Henning, Maj. J. Scott Firoz, Bahar F. TI Combat Dermatology: The Prevalence of Skin Disease in a Deployed Dermatology Clinic in Iraq SO JOURNAL OF DRUGS IN DERMATOLOGY LA English DT Article AB Background: Since July 2004, the United States (U.S.) Army has operated a forward-deployed dermatology clinic in Baghdad, Iraq. This paper outlines the prevalence of skin disease among deployed service men and women in Operation Iraqi Freedom. Methods: A cross-sectional study was performed for all dermatology visits presenting to the Combat Dermatology Clinic, Ibn Sina, Iraq, between January 15, 2008 and July 15, 2008. Results: In the six-month period reviewed, 2,696 total patients were evaluated. The most prevalent diagnoses included eczematous dermatitis [17%, n=462] and benign neoplasms [14%, n=375]. Eight percent (n=205) of the total visits were for skin cancer. This included: basal cell carcinoma, squamous cell carcinoma both in-situ and invasive, mycosis fungoides and melanoma. Actinic keratosis comprised 5% of the total visits (n=129). Bacterial infections comprised 6% (n=158) of the total visits and 31 of these cases were community acquired methicillin resistant Staphylococcus aureus (MRSA). Limitations: Cross-sectional study with referral bias. Conclusion: This is the largest publication of the prevalence of skin disease in an exclusively dermatologic clinic in a combat setting. For the first time the presence of skin cancer is noted in a combat setting. The prevalence of MRSA is noted and was exclusively seen in U.S. soldiers. There was a statistically significant rise in the prevalence of eczematous dermatitides when compared with previous conflicts. Dermatologists can have a significant and strategic impact on deployed military medicine. C1 [Henning, Maj. J. Scott] Brooke Army Med Ctr, Dept Dermatol, Ft Sam Houston, TX 78234 USA. [Firoz, Bahar F.] Methodist Hosp, Houston, TX 77030 USA. [Firoz, Bahar F.] Dermatol Surg Associates, Houston, TX USA. RP Henning, MJS (reprint author), Brooke Army Med Ctr, Dept Dermatol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM jeffrey.henning@lackland.af.mil NR 9 TC 1 Z9 1 U1 0 U2 0 PU JOURNAL OF DRUGS IN DERMATOLOGY PI NEW YORK PA 377 PARK AVE SOUTH, 6TH FLOOR, NEW YORK, NY 10016 USA SN 1545-9616 J9 J DRUGS DERMATOL JI J. Drugs Dermatol. PD MAR PY 2010 VL 9 IS 3 BP 210 EP 214 PG 5 WC Dermatology SC Dermatology GA 571IH UT WOS:000275745000003 ER PT J AU Pongruktham, O Ochs, C Hoover, JJ AF Pongruktham, Orathai Ochs, Clifford Hoover, Jan Jeffrey TI Observations of Silver Carp (Hypophthalmichthys molitrix) Planktivory in a Floodplain Lake of the Lower Mississippi River Basin SO JOURNAL OF FRESHWATER ECOLOGY LA English DT Article ID RESERVOIR; PASSAGE; BIOMASS; BRAZIL; VAL AB The invasive silver carp (Hypophthalmichthys molitrix) has become pervasive in much of the Mississippi River, its tributaries, and in connected lakes and wetlands. As an increasingly abundant planktivore, it competes directly for food with native fishes. Its greatest impact may be in connected backwater lakes and wetlands, which due to their high primary production serve as critical sites for feeding and growth of many fishes. To assess the impact that silver carp may have on one such system, we examined the composition of plankton samples and of alimentary tract (gut) contents of carp collected from an oxbow lake in Mississippi, Forest Home Chute. Through an occasional connection to the Mississippi River, Forest Home Chute was invaded by silver carp in winter 2005, after which the river and lake became disconnected for about two years. In the water-column, the most common types of phytoplankton were euglenoid algae, cyanobacteria, and diatoms. The vast majority of zooplankton was rotifers with densities sometimes exceeding 7,000 organisms per liter. Very high concentrations of phytoplankton in the carp gut, relative to in the water-column, indicate substantial consumption of phytoplankton production. In October 2006, euglenoid phytoplankters were a much greater, and cyanobacteria a much lesser, proportion of prey in the fish gut compared to their proportions in the water-column. In December, however, there was no evidence of selective consumption by the silver carp population. Some of the phytoplankters observed in the lowest portion of the gut, including pinnate diatoms and euglenoid algae, were motile, indicating they had survived transit through the 5 to 7-m long gut tract. There was no evidence of rotifer survival of gut passage. By its high consumption of plankton, possible selective planktivory, and differential digestion of consumed phytoplankton and zooplankton, the silver carp may be altering the food web structure of these important connected lakes. C1 [Pongruktham, Orathai; Ochs, Clifford] Univ Mississippi, Dept Biol, University, MS 38677 USA. [Hoover, Jan Jeffrey] USA, Engn Res & Dev Ctr, Waterways Expt Stn, Vicksburg, MS 39180 USA. RP Pongruktham, O (reprint author), Univ Mississippi, Dept Biol, University, MS 38677 USA. FU Department of Biology, University of Mississippi; US Army Corps of Engineers Aquatic Nuisance Species Research Program FX Assistance in the field was provided by J. Beard, H. Capello, S. George, J. Killgore, W. Lancaster, B. Lewis, C. Murphy, and K. Varble. Support for travel was provided by the Department of Biology, University of Mississippi and the US Army Corps of Engineers Aquatic Nuisance Species Research Program. Permission to publish was granted by the Chief of Engineers. NR 23 TC 5 Z9 6 U1 4 U2 22 PU OIKOS PUBL INC PI LA CROSSE PA PO BOX 2558, LA CROSSE, WI 54601 USA SN 0270-5060 J9 J FRESHWATER ECOL JI J. Freshw. Ecol. PD MAR PY 2010 VL 25 IS 1 BP 85 EP 93 DI 10.1080/02705060.2010.9664361 PG 9 WC Ecology; Limnology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA 565LH UT WOS:000275293500011 ER PT J AU Casper, AF Johnson, LE AF Casper, Andrew F. Johnson, Ladd E. TI Contrasting shell/tissue characteristics of Dreissena polymorpha and Dreissena bugensis in relation to environmental heterogeneity in the St. Lawrence River SO JOURNAL OF GREAT LAKES RESEARCH LA English DT Article DE Environmental heterogeneity; Physiological plasticity; Competition; Growth ID LOWER GREAT-LAKES; ZEBRA MUSSEL; QUAGGA MUSSELS; NORTH-AMERICA; ENERGY ALLOCATION; ZOOPLANKTON; REPLACEMENT; ESTUARIES; FREQUENCY; SALINITY AB The zebra mussel, Dreissena polymorpha, is widespread in the St. Lawrence River while the conspecific quagga mussel, Dreissena bugensis, is found only in the Lake Ontario outflow region of the river. This situation provided an opportunity to evaluate in situ environmental and interspecific heterogeneity in shell and tissue growth. Shell dry weight, carbon content, and shell strength of D. polymorpha from the four spatially discrete water masses differed significantly. For instance, D. polymorpha total and tissue mass increased over the summer in the shallow fluvial Lac Saint-Pierre but decreased in the upstream and downstream water masses. Standardized shell mass and strength of a polymorpha was lowest where the mussels experienced salinity or low calcium. Although the response pattern of mass and glycogen content for D. polymorpha was spatially complex, mussels from the stressful oligohaline estuary population had the weakest shells and lowest glycogen content, even though their standardized tissue mass was the heaviest. This disparity in shell and tissue response suggests that some aspect of shell physiology alone may be limiting these mussels in estuarine environments. Tissue characteristics of D. polymorpha and D. bugensis were similar at the site where both were present, but the shell strength of D. bugensis was only equivalent to the weakest of D. polymorpha. We also conclude that lighter shells might make D. bugensis more susceptible to predation or mechanical damage but may also offer a bioenergetic advantage that is contributing to its rapid displacement of D. polymorpha where the two species co-occur. Published by Elsevier B.V. C1 [Casper, Andrew F.] USA, Corps Engineers, Aquat Ecol & Invas Species Branch, Environm Lab,ERDC,Waterways Expt Stn, Vicksburg, MS 39180 USA. [Casper, Andrew F.; Johnson, Ladd E.] Univ Laval, Quebec Ocean & Dept Biol, Quebec City, PQ G1K 7P4, Canada. RP Casper, AF (reprint author), USA, Corps Engineers, Aquat Ecol & Invas Species Branch, Environm Lab,ERDC,Waterways Expt Stn, Vicksburg, MS 39180 USA. EM andrew.f.casper@usace.army.mil RI Johnson, Ladd/C-7449-2012 NR 35 TC 8 Z9 8 U1 2 U2 21 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0380-1330 J9 J GREAT LAKES RES JI J. Gt. Lakes Res. PD MAR PY 2010 VL 36 IS 1 BP 184 EP 189 DI 10.1016/j.jglr.2009.10.001 PG 6 WC Environmental Sciences; Limnology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA 573BE UT WOS:000275882600021 ER PT J AU Priddy, LP Newman, JK AF Priddy, Lucy Phillips Newman, John Kent TI Full-Scale Field Testing for Verification of Mechanical Properties of Polyurethane Foams for Use as Backfill in PCC Repairs SO JOURNAL OF MATERIALS IN CIVIL ENGINEERING LA English DT Article ID OPEN-CELL FOAMS; COMPRESSIVE RESPONSE; BEHAVIOR AB Laboratory and field investigations were performed on several commercially available rigid polyurethane foam materials to determine their suitability as base replacement materials for full-depth portland concrete cement (PCC) pavement repairs. Rigid polyurethane foam (RPF) specimens were prepared and tested to evaluate the compressive strength, reactivity, and density of several foam materials under a variety of temperature conditions, where properties were investigated for thermal variations expected in field placement. Following laboratory testing, full-scale field testing of full-depth PCC repairs was conducted using two RPFs of densities of approximately 160 kg/m(3) (10 lb/ft(3)) and 240 kg/m(3) (15 lb/ft(3)) to verify laboratory predicted performance under elevated and ideal field temperatures. Each repair was trafficked within 3 h of repair completion with an F-15E load cart to simulate fighter aircraft traffic on early-age repairs. Results of laboratory and field testing indicate that high-density RPF materials are suitable as base replacement materials for temporary pavement repairs on airfields. For optimum field performance a RPF with minimum density of 240 kg/m(3) (15 lb/ft(3)) should be placed at a temperature of 23 degrees C (70 degrees F). C1 [Priddy, Lucy Phillips; Newman, John Kent] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Priddy, LP (reprint author), USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM Lucy.P.Priddy@usace.army.mil; John.K.Newman@usace.army.mil FU Headquarters, Air Combat Command; U.S. Army Engineering Research and Development Center, Waterways Experiment Station FX The tests described and the resulting data presented herein, unless otherwise noted, were obtained from research conducted under the Airfield Damage Repair (ADR) Civil Engineer Modernization program currently sponsored by Headquarters, Air Combat Command by the U.S. Army Engineering Research and Development Center, Waterways Experiment Station. Permission was granted by the laboratory director to publish this information. The Headquarters, Department of the Army, sponsored the research reported herein. The support of the U.S. Army Engineer Research and Development Center, Waterways Experiment Station, is gratefully acknowledged. The U.S. Army Engineer Research and Development Center does not endorse any of the materials reported herein. NR 17 TC 6 Z9 6 U1 3 U2 7 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0899-1561 J9 J MATER CIVIL ENG JI J. Mater. Civ. Eng. PD MAR PY 2010 VL 22 IS 3 BP 245 EP 252 DI 10.1061/(ASCE)0899-1561(2010)22:3(245) PG 8 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA 555OQ UT WOS:000274522200006 ER PT J AU Kupp, ER Messing, GL Anderson, JM Gopalan, V Dumm, JQ Kraisinger, C Ter-Gabrielyan, N Merkle, LD Dubinskii, M Simonaitis-Castillo, VK Quarles, GJ AF Kupp, Elizabeth R. Messing, Gary L. Anderson, Julie M. Gopalan, Venkatraman Dumm, John Q. Kraisinger, Charles Ter-Gabrielyan, Nikolay Merkle, Larry D. Dubinskii, Mark Simonaitis-Castillo, Vida K. Quarles, Gregory J. TI Co-casting and optical characteristics of transparent segmented composite Er:YAG laser ceramics SO JOURNAL OF MATERIALS RESEARCH LA English DT Article ID ND-YAG CERAMICS; PERFORMANCE; POLYCRYSTALLINE; FABRICATION; ROD AB A novel colloidal co-casting process was developed to fabricate laser quality, multisegment composite ceramic laser gain materials. The approach was demonstrated for a three segment transparent composite rod 62 mm long by 3 mm diameter consisting of undoped yttrium aluminus garnet (YAG), 0.25% Er:YAG, and 0.5% Er:YAG. The Er concentration profile in the composite has steep, controllable gradients at the segment interfaces, while maintaining constant dopant concentrations within each segment. The composite rod has 84% transmittance at 1645 nm (the lasing wavelength) with a scatter loss of 0.4% cm(-1). Laser operation of such a composite Er:YAG ceramic rod was demonstrated for the first time, with nearly equivalent lasing behavior to an Er:YAG single crystal rod. C1 [Kupp, Elizabeth R.; Messing, Gary L.; Anderson, Julie M.; Gopalan, Venkatraman] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. [Kupp, Elizabeth R.; Messing, Gary L.; Anderson, Julie M.; Gopalan, Venkatraman] Penn State Univ, Mat Res Inst, University Pk, PA 16802 USA. [Dumm, John Q.; Kraisinger, Charles] II VI Inc, AMDC, Saxonburg, PA 16056 USA. [Ter-Gabrielyan, Nikolay; Merkle, Larry D.; Dubinskii, Mark] USA, Res Lab, RDRL SEE O, Adelphi, MD 20783 USA. [Simonaitis-Castillo, Vida K.; Quarles, Gregory J.] II VI Inc, VLOC, New Port Richey, FL 34655 USA. RP Kupp, ER (reprint author), Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. EM kupp@matse.psu.edu FU High Energy Laser program of the Joint Technology Office [FA9451-06-D-0012]; National Science Foundation [DMR07-49391] FX This work was supported by the High Energy Laser program of the Joint Technology Office under Contract FA9451-06-D-0012 and the National Science Foundation under Contract DMR07-49391. NR 22 TC 35 Z9 40 U1 2 U2 27 PU MATERIALS RESEARCH SOC PI WARRENDALE PA 506 KEYSTONE DR, WARRENDALE, PA 15086 USA SN 0884-2914 J9 J MATER RES JI J. Mater. Res. PD MAR PY 2010 VL 25 IS 3 BP 476 EP 483 DI 10.1557/JMR.2010.0069 PG 8 WC Materials Science, Multidisciplinary SC Materials Science GA 564NG UT WOS:000275221100009 ER PT J AU Sood, AK Puri, YR Wang, ZL Polla, DL Soprano, MB AF Sood, Ashok K. Puri, Yash R. Wang, Zhong L. Polla, Dennis L. Soprano, Martin B. TI Growth of Highly Oriented ZnO Nanowires on GaN Substrates for Electronic and Optical Sensor Applications SO JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY LA English DT Article DE ZnO; Nanowires; p-n Junctions; UV Imaging; Highly Oriented ZnO Growth; Electronic Applications AB In this Paper we present growth and characterization results of highly oriented ZnO nanowires grown on wide bandgap GaN substrates. Experimental results on the ZnO nanowires grown on p-GaN are presented with growth morphology and dimensionality control. We also present experimental results on these nanowire arrays such as I-V measurements and UV sensitivity measurements. The ZnO nanowires can be used for a variety of nanoscale optical and electronics applications. C1 [Sood, Ashok K.; Puri, Yash R.] Magnolia Opt Technol Inc, Woburn, MA 01801 USA. [Wang, Zhong L.] Georgia Inst Technol, Sch Mat Sci, Atlanta, GA 30332 USA. [Polla, Dennis L.] DARPA MTO, Arlington, VA 22203 USA. [Soprano, Martin B.] USA, DARPA Programs Off, Redstone Arsenal, AL 35898 USA. RP Sood, AK (reprint author), Magnolia Opt Technol Inc, 52-B Cummings Pk,Suite 314, Woburn, MA 01801 USA. RI Wang, Zhong Lin/E-2176-2011 OI Wang, Zhong Lin/0000-0002-5530-0380 FU DARPA; US Army [W31P4QO6-C-0262] FX This work has been sponsored by DARPA and funded under US Army Contract Number W31P4QO6-C-0262. NR 8 TC 9 Z9 9 U1 1 U2 17 PU AMER SCIENTIFIC PUBLISHERS PI STEVENSON RANCH PA 25650 NORTH LEWIS WAY, STEVENSON RANCH, CA 91381-1439 USA SN 1533-4880 J9 J NANOSCI NANOTECHNO JI J. Nanosci. Nanotechnol. PD MAR PY 2010 VL 10 IS 3 SI SI BP 1839 EP 1841 DI 10.1166/jnn.2010.2110 PG 3 WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 548RV UT WOS:000273984800053 PM 20355584 ER PT J AU Cardellina, JH Moore, BS AF Cardellina, John H., II Moore, Bradley S. TI Richard C. Moore (1933-2007) SO JOURNAL OF NATURAL PRODUCTS LA English DT Biographical-Item ID BLUE-GREEN-ALGAE; LYNGBYA-MAJUSCULA; SCYTONEMA; ALKALOIDS; SCYTOPHYCINS; PALYTOXIN C1 [Cardellina, John H., II] USA, Inst Infect Dis, Washington, DC 20310 USA. [Moore, Bradley S.] Univ Calif San Diego, San Diego, CA 92103 USA. RP Cardellina, JH (reprint author), USA, Inst Infect Dis, Washington, DC 20310 USA. NR 18 TC 6 Z9 6 U1 0 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0163-3864 J9 J NAT PROD JI J. Nat. Prod. PD MAR PY 2010 VL 73 IS 3 SI SI BP 301 EP 302 DI 10.1021/np100045f PG 2 WC Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy SC Plant Sciences; Pharmacology & Pharmacy GA 573CC UT WOS:000275885000002 PM 20141160 ER PT J AU Boyles, RE Walker, MJ Young, BA Strunce, JB Wainner, RS AF Boyles, Robert E. Walker, Michael J. Young, Brian A. Strunce, Joseph B. Wainner, Robert S. TI The Addition of Cervical Thrust Manipulations to a Manual Physical Therapy Approach in Patients Treated for Mechanical Neck Pain: A Secondary Analysis SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE cervical spine; manual therapy; mobilization ID RANDOMIZED CLINICAL-TRIAL; THORACIC SPINE MANIPULATION; LOW-BACK-PAIN; GENERAL-PRACTITIONER; DISABILITY INDEX; PREDICTION RULE; CONTINUED CARE; EXERCISE; MOBILIZATION; HEALTH AB STUDY DESIGN: Secondary analysis of a randomized clinical trial (RCT). OBJECTIVES: To perform a secondary analysis on the treatment arm of a larger RCT to determine differences in treatment outcomes, adverse reactions, and effect sizes between patients who received cervical thrust manipulation and those who received only nonthrust manipulation as part of an impairment-based, multimodal treatment program of manual physical therapy (MPT) and exercise for patients with mechanical neck pain. BACKGROUND: A treatment regimen of MPT and exercise has been effective in patients with mechanical neck pain. Limited research has compared the effectiveness of cervical thrust manipulations and nonthrust mobilizations for this patient population, and no studies have investigated the added benefit of cervical thrust manipulations as part of an overall MPT treatment plan. METHODS: Treatment outcomes from 47 patients in the treatment arm of a larger RCT with a primary complaint of mechanical neck pain, were analyzed. Twenty-three patients (49%) received cervical thrust manipulations as part of their MPT treatment, and 24 patients (51%) received only cervical nonthrust mobilizations. All patients received up to 6 clinic sessions, twice weekly for 3 weeks, and a home exercise program. Primary outcome measures were the Neck Disability Index (NDI), 2 visual analog scales for cervical and upper extremity pain, and a 15-point global rating of change scale. Blinded outcome measurements were collected at baseline and at 3-, 6- and 52-week follow-ups. RESULTS: Consistent with the larger RCT, both subgroups in this secondary analysis demonstrated improvement in short- and long-term pain and disability scores. Low statistical power (beta <=.28) and the resultant small effect size indices (-0.21 to 0.17) preclude the identification of any between-group differences. No serious adverse reactions were reported by patients in either subgroup. CONCLUSIONS: Clinically meaningful and statistically significant improvements in both subgroups of patients over time suggest that cervical thrust manipulation, as part of the MPT treatment plan, did not influence the results of the treatment arm of the larger RCT from which this study was drawn. Although no between-group differences can be identified, the small observed effect sizes in this study may benefit future studies with sample size estimation for larger RCTs and indicate the need to incorporate clinical prediction rule criteria as a means to improve statistical power. C1 [Boyles, Robert E.] Univ Puget Sound, Sch Phys Therapy, Tacoma, WA 98416 USA. [Walker, Michael J.] Baylor Univ, Doctoral Program Phys Therapy, USA, Ft Sam Houston, TX USA. [Young, Brian A.] USAF, Sheppard AFB, TX USA. [Strunce, Joseph B.] No Navajo Med Ctr, Rehabil Dept, Shiprock, NM USA. [Wainner, Robert S.] Texas State Univ, Dept Phys Therapy, San Marcos, TX USA. RP Boyles, RE (reprint author), Univ Puget Sound, Sch Phys Therapy, 1500 N Warner St,1070, Tacoma, WA 98416 USA. EM bboyles@pugetsound.edu NR 41 TC 9 Z9 9 U1 1 U2 13 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD MAR PY 2010 VL 40 IS 3 BP 133 EP 140 DI 10.2519/jospt.2010.3106 PG 8 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 561CD UT WOS:000274952100002 PM 20195023 ER PT J AU Elster, EA Stojadinovic, A Forsberg, J Shawen, S Andersen, RC Schaden, W AF Elster, Eric A. Stojadinovic, Alexander Forsberg, Jonathan Shawen, Scott Andersen, Romney C. Schaden, Wolfgang TI Extracorporeal Shock Wave Therapy for Nonunion of the Tibia SO JOURNAL OF ORTHOPAEDIC TRAUMA LA English DT Article DE ESWT; nonunion; fracture ID INTENSITY PULSED ULTRASOUND; CALCIFIC TENDINITIS; PLANTAR FASCIITIS; CONTROLLED-TRIAL; SINGLE-BLIND; FRACTURES; BONE; SHOULDER; DEFECTS; UNION AB Objectives: Delayed and nonunion of the tibia are not uncommon in orthopaedic practice. Multiple methods of treatment have been developed with variable results. The objective of this study was to define disease-specific and treatment-related factors of prognostic significance in patients undergoing shock wave therapy for tibia nonunion. Design: Retrospective analysis. Patients: One hundred ninety-two patients treated with extracorporeal shock wave therapy (ESWT) at a single referral trauma center, AUVA-Trauma Center Meidling, a large single-referral trauma center located in Vienna, Austria, in an attempt to determine the feasibility and factors associated with the use of ESWT in the treatment for tibia nonunion. Intervention: ESWT coupled with posttreatment immobilization, external fixation, or ESWT alone. Main Outcome Measures: Fracture healing, overall healing percent, and factors associated with ESWT success or failure. Results: At the time of last follow up, 138 of 172 (80.2%) patients have demonstrated complete fracture healing. Mean time from first shock wave therapy to complete healing of the tibia nonunion was 4.8 +/- 4.0 months. Number of orthopaedic operations (P = 0.003), shock wave treatments (P = 0.002), and pulses delivered (P = 0.04) were significantly associated with complete bone healing. Patients requiring multiple (more than one) shock wave treatments versus a single treatment had a significantly lower likelihood of fracture healing (P = 0.003). This may be attributable to the finding that a significantly greater proportion of patients with multiple rather than single ESWT treatments had three or more prior orthopaedic procedures (more than one ESWT, 63.9% versus one ESWT, 23.5%; P < 0.001). Conclusions: ESWT is a feasible treatment modality for tibia nonunion. C1 [Elster, Eric A.] NNMC Bethesda, NMRC, Dept Surg, Silver Spring, MD 20910 USA. [Elster, Eric A.; Forsberg, Jonathan] Natl Naval Med Ctr, Combat Wound Initiat, Bethesda, MD USA. [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Combat Wound Initiat, Washington, DC 20307 USA. [Schaden, Wolfgang] AUVA Trauma Ctr Meidling, Vienna, Austria. [Shawen, Scott; Andersen, Romney C.] Walter Reed Army Med Ctr, Orthopaed Surg Serv, Washington, DC 20307 USA. [Forsberg, Jonathan] Natl Naval Med Ctr, Dept Orthopaed Surg, Bethesda, MD USA. RP Elster, EA (reprint author), NNMC Bethesda, NMRC, Dept Surg, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM eric.elster@med.navy.mil NR 52 TC 38 Z9 43 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0890-5339 J9 J ORTHOP TRAUMA JI J. Orthop. Trauma PD MAR PY 2010 VL 24 IS 3 BP 133 EP 141 DI 10.1097/BOT.0b013e3181b26470 PG 9 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 564DK UT WOS:000275193300001 PM 20182248 ER PT J AU Mishchenko, MI Zakharova, NT Videen, G Khlebtsov, NG Wriedt, T AF Mishchenko, Michael I. Zakharova, Nadia T. Videen, Gorden Khlebtsov, Nikolai G. Wriedt, Thomas TI Comprehensive T-matrix reference database: A 2007-2009 update SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Review DE Electromagnetic scattering; T-matrix method ID ELECTROMAGNETIC-WAVES SCATTERING; CORE-SATELLITE NANOASSEMBLIES; LAGUERRE-GAUSSIAN BEAMS; LIGHT-SCATTERING; NONSPHERICAL PARTICLES; OPTICAL-PROPERTIES; POLARIMETRIC-RADAR; EXPERIMENTAL-VERIFICATION; GOLD NANOPARTICLES; BIOLOGICAL TISSUE AB The T-matrix method is among the most versatile, efficient, and widely used theoretical techniques for the numerically exact computation of electromagnetic scattering by homogeneous and composite particles, clusters of particles, discrete random media, and particles in the vicinity of an interface separating two half-spaces with different refractive indices. This paper presents an update to the comprehensive database of T-matrix publications compiled by us previously and includes the publications that appeared since 2007. It also lists several earlier publications not included in the original database. Published by Elsevier Ltd. C1 [Mishchenko, Michael I.] NASA, Goddard Inst Space Studies, New York, NY 10025 USA. [Zakharova, Nadia T.] Sigma Space Partners, New York, NY 10025 USA. [Videen, Gorden] USA, Res Lab, AMSRL IS EE, Adelphi, MD 20783 USA. [Khlebtsov, Nikolai G.] Russian Acad Sci, Inst Biochem & Physiol Plants & Microorganisms, Saratov 410015, Russia. [Wriedt, Thomas] Inst Werkstofftech, D-28359 Bremen, Germany. RP Mishchenko, MI (reprint author), NASA, Goddard Inst Space Studies, 2880 Broadway, New York, NY 10025 USA. EM mmishchenko@giss.nasa.gov RI Mishchenko, Michael/D-4426-2012; Khlebtsov, Nikolai/D-6199-2017; Pylaev, Timofey/A-8401-2016; OI Pylaev, Timofey/0000-0002-2701-3333; Khlebtsov, Nikolai/0000-0002-2055-7784 FU NASA FX We thank Josefina Mora and Zoe Wai for helping to obtain copies of publications that were not readily accessible. This project was sponsored by the NASA Radiation Sciences Program managed by Hal Mating. NR 259 TC 40 Z9 41 U1 1 U2 17 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD MAR PY 2010 VL 111 IS 4 BP 650 EP 658 DI 10.1016/j.jqsrt.2009.11.002 PG 9 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 549QY UT WOS:000274069900012 ER PT J AU Berg, MJ Sorensen, CM Chakrabarti, A AF Berg, M. J. Sorensen, C. M. Chakrabarti, A. TI Explanation of the patterns in Mie theory SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article DE Electromagnetic scattering; Light scattering; Mie theory; Guinier law; Porod law; Phase function ID LIGHT-SCATTERING; SPHERES; FIELD; PARTICLES; RESONANCE AB The far-field scattered light intensity, or the related phase function, for a spherical particle is known to display an overall power-law structure when formulated in terms of the scattering wave vector. Empirically determined patterns in the intensity relating to the particle size and refractive index are known. The cause of the patterns, however, has not been satisfactorily explained. This work applies an exact microphysical model to explain most of the patterns, and specifically, to reveal the physical cause of crossovers from one power-law to another. A unique aspect of this microphysical approach is phasor analysis, which provides a visually based way to examine the angle-dependent wavelet superposition involved in the model A simple color coding scheme connects the phasors to the interior of the particle. and it is this connection that reveals the meaning of the crossovers. (C) 2009 Elsevier Ltd. All rights reserved C1 [Sorensen, C. M.; Chakrabarti, A.] Kansas State Univ, Dept Phys, Manhattan, KS 66506 USA. [Berg, M. J.] USA, Res Lab, RDRL CIE S, Adelphi, MD 20783 USA. RP Sorensen, CM (reprint author), Kansas State Univ, Dept Phys, Cardwell Hall, Manhattan, KS 66506 USA. RI Sorensen, Christopher/G-4900-2013 OI Sorensen, Christopher/0000-0002-1980-3394 FU National Research Council; United States Defense Threat Reduction Agency [DAAD17-03-C-0070] FX This work was partly supported by the National Research Council postdoctoral associateship program funded by the United States Defense Threat Reduction Agency, Contract no. DAAD17-03-C-0070. NR 36 TC 11 Z9 11 U1 2 U2 18 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD MAR PY 2010 VL 111 IS 5 BP 782 EP 794 DI 10.1016/j.jqsrt.2009.11.010 PG 13 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 562RB UT WOS:000275070100010 ER PT J AU Kortan, N Roberts, J Roebuck, J AF Kortan, Nicholas Roberts, Jefferson Roebuck, Jonathan TI Gout Masquerading as a Triquetral Fracture SO JOURNAL OF RHEUMATOLOGY LA English DT Editorial Material C1 [Kortan, Nicholas; Roberts, Jefferson; Roebuck, Jonathan] Walter Reed Army Med Ctr, Dept Rheumatol, Washington, DC 20307 USA. RP Kortan, N (reprint author), Walter Reed Army Med Ctr, Dept Rheumatol, Bldg 2,6900 Georgia Ave NW, Washington, DC 20307 USA. EM Nicholas.kortan@amedd.army.mil NR 3 TC 1 Z9 2 U1 0 U2 0 PU J RHEUMATOL PUBL CO PI TORONTO PA 920 YONGE ST, SUITE 115, TORONTO, ONTARIO M4W 3C7, CANADA SN 0315-162X J9 J RHEUMATOL JI J. Rheumatol. PD MAR PY 2010 VL 37 IS 3 BP 670 EP 671 DI 10.3899/jrheum.091000 PG 2 WC Rheumatology SC Rheumatology GA 563MD UT WOS:000275135700033 PM 20197566 ER PT J AU Romasco, AL Friedman, LH Fang, L Meirom, RA Clark, TC Polcawich, R Pulskamp, J Dubey, M Muhlstein, CL AF Romasco, A. L. Friedman, L. H. Fang, L. Meirom, R. A. Clark, T. C. Polcawich, R. Pulskamp, J. Dubey, M. Muhlstein, C. L. TI Practical Implications of Instrument Displacement Drift during Force-Controlled Nanoindentation SO JOURNAL OF TESTING AND EVALUATION LA English DT Article DE Instrumented indentation; nanoindentation; drift ID DEPTH-SENSING INDENTATION; THIN-FILMS; MECHANICAL-PROPERTIES; SURFACE-ROUGHNESS; STRAIN-RATE; HARDNESS; MODULUS; CREEP AB The accuracy of instrumented indentation data relies heavily on the evaluation of experimental errors such as displacement drift. In spite of its importance, little attention has been given to the magnitude of an acceptable displacement drift rate, its relationship to a given set of test conditions, and how errors manifest themselves in force-displacement data. In this work we explored how drift rates that were acceptable for short-term tests caused artificial "abnormal" behavior that could have been interpreted as a true material response for a longer-term test. A critical review of the drift behavior of the nanoindentation system revealed that a useful metric for screening data quality was the nominal accumulated system drift as a fraction of the maximum penetration depth. Additionally, suggestions for drift management during nanoindentation tests were given. C1 [Romasco, A. L.; Meirom, R. A.; Muhlstein, C. L.] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. [Polcawich, R.; Pulskamp, J.; Dubey, M.] USA, Res Lab, Adelphi, MD 20783 USA. [Clark, T. C.] Penn State Univ, Mat Res Inst, University Pk, PA 16802 USA. [Friedman, L. H.; Fang, L.] Penn State Univ, Dept Engn Sci & Mech, University Pk, PA 16802 USA. RP Muhlstein, CL (reprint author), Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. EM clm28@psu.edu RI Friedman, Lawrence/G-5650-2011 OI Friedman, Lawrence/0000-0003-2416-9903 FU U.S. Army Research Office [ARO 48355EG]; National Science Foundation [0528234, 0335765]; Pennsylvania State University Materials Research Institute NanoFabrication Network; National Nanotechnology Infrastructure Network, Cornell University FX The writers acknowledge the support of the U.S. Army Research Office (Grant No. ARO 48355EG, program manager Dr. Bruce La-Mattina) and the National Science Foundation (CMS Program No. 0528234, program manager Dr. Ken Chong). The writers would also like to thank the contributions of Prashant Ranade of General Technical Services for his role in the fabrication of the platinum thin films. This work was also supported by the Pennsylvania State University Materials Research Institute NanoFabrication Network and the National Science Foundation Cooperative Agreement No. 0335765, and National Nanotechnology Infrastructure Network, with Cornell University. Any opinions, findings, and conclusions or recommendations expressed in this publication are those of the writer(s) and do not necessarily reflect the views of Cornell University nor those of the National Science Foundation. NR 24 TC 0 Z9 0 U1 0 U2 4 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 USA SN 0090-3973 EI 1945-7553 J9 J TEST EVAL JI J. Test. Eval. PD MAR PY 2010 VL 38 IS 2 BP 203 EP 210 DI 10.1520/JTE102177 PG 8 WC Materials Science, Characterization & Testing SC Materials Science GA 570OE UT WOS:000275686800009 ER PT J AU Albert, DG Liu, LB AF Albert, Donald G. Liu, Lanbo TI The effect of buildings on acoustic pulse propagation in an urban environment SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID SOUND-PROPAGATION; STREET CANYONS; NOISE; MEDIA; AREAS; MODEL AB Experimental measurements were conducted using acoustic pulse sources in a full-scale artificial village to investigate the reverberation, scattering, and diffraction produced as acoustic waves interact with buildings. These measurements show that a simple acoustic source pulse is transformed into a complex signature when propagating through this environment, and that diffraction acts as a low-pass filter on the acoustic pulse. Sensors located in non-line-of-sight (NLOS) positions usually recorded lower positive pressure maxima than sensors in line-of-sight positions. Often, the first arrival on a NLOS sensor located around a corner was not the largest arrival, as later reflection arrivals that traveled longer distances without diffraction had higher amplitudes. The waveforms are of such complexity that human listeners have difficulty identifying replays of the signatures generated by a single pulse, and the usual methods of source location based on the direction of arrivals may fail in many cases. Theoretical calculations were performed using a two-dimensional finite difference time domain (FDTD) method and compared to the measurements. The predicted peak positive pressure agreed well with the measured amplitudes for all but two sensor locations directly behind buildings, where the omission of rooftop ray paths caused the discrepancy. The FDTD method also produced good agreement with many of the measured waveform characteristics. (C) 2010 Acoustical Society of America. [DOI: 10.1121/1.3277245] C1 [Albert, Donald G.] USA, Erdc, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Liu, Lanbo] Univ Connecticut, Dept Civil & Environm Engn, Storrs, CT 06269 USA. RP Albert, DG (reprint author), USA, Erdc, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. FU PM-CCS; U.S. Army Corps of Engineers Engineering Research and Development Center FX We thank the late Mr. Rich Andrejkovics and Mr. Andre Edwin, SYDET Project Officer of PM-CCS, for funding the experimental measurements presented here. This paper is dedicated to Rich's memory. The analysis was funded by the U.S. Army Corps of Engineers Engineering Research and Development Center research program. We also thank the many people who assisted with the field measurements, including David Carbee, Stephen Decato, and Dr. Joyce Nagle (ERDC-CRREL); Chris Reiff and Herb Brann (Army Research Laboratory); Gary Leadore, George Eason, Thomas Ruffing, Patrick Whaling, and James Aguiar (Aberdeen Test Center); Ron Akers, Stan Ellis, George Eason, and others from Fort Benning. In addition, Major Joseph Haydon (U.S. Army) assisted with the measurement design, Dr. Joyce Nagle conducted a review of the urban acoustic literature used in this paper, and David Leese (ERDC-ITL) provided meteorological data. We also thank two anonymous reviewers for useful comments that improved the manuscript. NR 29 TC 13 Z9 13 U1 2 U2 12 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD MAR PY 2010 VL 127 IS 3 BP 1335 EP 1346 DI 10.1121/1.3277245 PN 1 PG 12 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 573TO UT WOS:000275938000025 PM 20329833 ER PT J AU Thorne, DR AF Thorne, David R. TI THE IDENTIFIES HIDDEN IN THE MATCHING LAWS, AND THEIR USES SO JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR LA English DT Article DE matching; law; compound schedules; concurrent schedules; identity; tautology; behavioral economics; foraging ID QUANTITATIVE-ANALYSIS; CONCURRENT CHOICE; REINFORCEMENT; SCHEDULES; RESPONSES AB Various theoretical equations have been proposed to predict response rate as a function of the rate of reinforcement. If both the rate and probability of reinforcement are considered, a simple identity, defining equation, or "law" holds. This identity places algebraic constraints on the allowable forms of our mathematical models and can help identify the referents for certain empirical or theoretical coefficients. This identity can be applied to both single and compound schedules of reinforcement, absolute and relative measures, and to local, global and overall rates and probabilities. The rate matching equations of Hernstein and Catania appear to have been approximations to, and to have been evolving toward, one form of this algebraic identity. Estimates of the bias and sensitivity terms in the generalized ratio and logarithmic matching models are here held to be averaging artifacts arising from fitting procedures applied to models that violate or conceal the underlying identities. C1 Walter Reed Army Inst Res, Div Psychiat & Neurosci, Dept Behav Biol, Silver Spring, MD 20910 USA. RP Thorne, DR (reprint author), Walter Reed Army Inst Res, Div Psychiat & Neurosci, Dept Behav Biol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM david.thorne@us.army.mil NR 22 TC 2 Z9 2 U1 1 U2 2 PU SOC EXP ANALYSIS BEHAVIOR INC PI BLOOMINGTON PA INDIANA UNIV DEPT PSYCHOLOGY, BLOOMINGTON, IN 47405 USA SN 0022-5002 J9 J EXP ANAL BEHAV JI J. Exp. Anal. Behav. PD MAR PY 2010 VL 93 IS 2 BP 247 EP 260 DI 10.1901/jeab.2010.93-247 PG 14 WC Psychology, Biological; Behavioral Sciences; Psychology, Experimental SC Psychology; Behavioral Sciences GA 566PH UT WOS:000275384500007 PM 20885813 ER PT J AU Teague, NS Srijan, A Wongstitwilairoong, B Poramathikul, K Champathai, T Ruksasiri, S Pavlin, J Mason, CJ AF Teague, Nathan S. Srijan, Apichai Wongstitwilairoong, Boonchai Poramathikul, Kamonporn Champathai, Thanaporn Ruksasiri, Supaporn Pavlin, Julie Mason, Carl J. TI Enteric Pathogen Sampling of Tourist Restaurants in Bangkok, Thailand SO JOURNAL OF TRAVEL MEDICINE LA English DT Article ID ARCOBACTER-BUTZLERI; TRAVELERS DIARRHEA; ANTIBIOTIC-RESISTANCE; FOODBORNE DISEASE; RETAIL FOODS; CAMPYLOBACTER; PREVALENCE; EPIDEMIOLOGY; RISK; SPP. AB Methods. A cross-sectional tourist restaurant survey was conducted. Thirty-five restaurants recommended in the two top selling Bangkok guidebooks on Amazon.com were sampled for bacterial pathogens known to cause diarrhea in Thailand, namely Salmonella, Campylobacter, and Arcobacter (a Campylobacter-like organism). A total of 70 samples from two meals at each restaurant were obtained. Suspected bacterial pathogens were isolated by differential culture and tested for antibiotic resistance. Results. Salmonella group E was isolated from one meal (2%), and Arcobacter butzleri from nine meals (13%). Campylobacter spp. were not found. The large majority of A butzleri isolates were resistant to azithromycin but susceptible to ciprofloxacin and an aminoglycoside. Conclusions. A traveler's risk of exposure to established bacterial pathogens, Salmonella and Campylobacter, by eating in recommended restaurants is small. Arcobacter butzleri exposure risk is 13% per meal eaten, and rises to 75% when 10 meals are eaten. All restaurants, regardless of price, appear to be equally "risky." Current evidence points to Arcobacter being pathogenic in humans; however, further research is needed to conclusively define pathogenicity. Routine prophylaxis for diarrhea is not recommended; however, travelers should be aware of the risk and come prepared with adequate and appropriate self-treatment medications. C1 [Teague, Nathan S.] Madigan Army Med Ctr, Dept Prevent Med, Ft Lewis, WA 98431 USA. [Srijan, Apichai; Wongstitwilairoong, Boonchai; Poramathikul, Kamonporn; Champathai, Thanaporn; Ruksasiri, Supaporn; Pavlin, Julie; Mason, Carl J.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Teague, NS (reprint author), Madigan Army Med Ctr, Dept Prevent Med, Bldg 9920, Ft Lewis, WA 98431 USA. EM nathan.teague@us.army.mil RI Valle, Ruben/A-7512-2013; OI MASON, CARL/0000-0002-3676-2811 FU US Department of Defense; Global Emerging Infections Surveillance and Response System; Overseas Tropical Medicine Training Program FX Special thanks to AFRIMS staff for technical support. Financial support for travel was obtained through the US Department of Defense, Global Emerging Infections Surveillance and Response System, Overseas Tropical Medicine Training Program. This study was exempt from Human Investigation Committee review under the following part of the US federal regulations: 45 CFR Part 46.101(b)(4). This study is not a clinical trial and does not need to be registered. NR 42 TC 10 Z9 10 U1 0 U2 4 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1195-1982 J9 J TRAVEL MED JI J. Travel Med. PD MAR-APR PY 2010 VL 17 IS 2 BP 118 EP 123 DI 10.1111/j.1708-8305.2009.00388.x PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 563DD UT WOS:000275106600008 PM 20412179 ER PT J AU Sears, CLG Lewis, C Noel, K Albright, TS Fischer, JR AF Sears, Christine L. G. Lewis, Christa Noel, Kathleen Albright, Todd S. Fischer, John R. TI Overactive Bladder Medication Adherence When Medication is Free to Patients SO JOURNAL OF UROLOGY LA English DT Article DE urinary bladder, overactive; muscarinic antagonists; delivery of health care; military personnel; medication adherence ID POPULATION; PERSISTENCE; EXPERIENCE; SYMPTOMS; RELEASE AB Purpose: We examined overactive bladder medication compliance in a health care system in which patients do not pay for medication. Materials and Methods: Pharmacy dispensing records were reviewed for anti-muscarinic agents from January 2003 to December 2006 for the United States Military Health System National Capital Region. Medication nonpersistence, switching and adherence were examined. Kaplan-Meier survival analysis was done to compare medication persistence duration. Results: Overactive bladder medications were dispensed to 7,879 adults. Tolterodine extended release (4,716 patients or 60%) and oxybutynin immediate release (2,003 or 25.5%) were most commonly prescribed. The medication nonpersistence rate, defined as the proportion of patients who never refilled a prescription for antimuscarinics during the study period, was 35.1% (2,760 of 7,858). Of 5,098 patients who refilled a prescription 1,305 changed the medication or dose at least once for a medication switch rate of 25.6%. The overall median medication possession ratio, defined as the total days of medication dispensed except for the last refill divided by the number of days between the first dispense date and the last refill date, was 0.82 in all cases. Men had a significantly higher median medication possession ratio than women (0.86 vs 0.81, p <0.001). Of patients who obtained at least 1 refill women remained on medication longer than men (median 606 vs 547 days, p = 0.01). Patients on tolterodine extended release had a higher medication nonpersistence rate than those on oxybutynin immediate release (0.89 vs 0.68, p <0.01). There was no difference between extended release medications. Conclusions: In a health care system in which patients do not pay for medications 35% of patients did not refill a prescription for overactive bladder medication, similar to previous reports. However, other measures of medication compliance were higher than those published previously in systems with copays. C1 [Sears, Christine L. G.] Natl Naval Med Ctr, Dept Urol, Bethesda, MD 20889 USA. [Sears, Christine L. G.; Noel, Kathleen; Albright, Todd S.; Fischer, John R.] Walter Reed Army Med Ctr, Natl Capitol Consortium Fellowship Female Pelv Me, Washington, DC 20307 USA. [Lewis, Christa; Albright, Todd S.; Fischer, John R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Sears, CLG (reprint author), Natl Naval Med Ctr, Dept Urol, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM Christine.Sears@med.navy.mil NR 13 TC 36 Z9 37 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 J9 J UROLOGY JI J. Urol. PD MAR PY 2010 VL 183 IS 3 BP 1077 EP 1081 DI 10.1016/j.juro.2009.11.026 PG 5 WC Urology & Nephrology SC Urology & Nephrology GA 558NJ UT WOS:000274750100097 PM 20092838 ER PT J AU Sanamyan, T Simmons, J Dubinskii, M AF Sanamyan, T. Simmons, J. Dubinskii, M. TI Er3+-doped Y2O3 ceramic laser at similar to 2.7 mu m with direct diode pumping of the upper laser level SO LASER PHYSICS LETTERS LA English DT Article DE solid-state laser; diode pumped; Er-doped laser; mid-IR laser ID MULTIPHONON RELAXATION; TEMPERATURE; EMISSION; YAG; CW AB We report relevant spectroscopy and efficient diode-pumped similar to 2.7-mu m laser operation of Er3+:Y2O3 ceramic resonantly pumped into upper laser level I-4(11/2). This is believed to be the first laser demonstration based on I-4(11/2) -> I-4(13/2) transitions of Er3+ in Y2O3. [GRAPHICS] Effective room temperature emission cross section of Er 31 ions in Er3+(0.5 at.%):Y2O3 laser ceramic derived from measured (C) 2010 by Astro Ltd. Published exclusively by WILEY-VCH Verlag GmbH & Co. KGaA C1 [Sanamyan, T.; Simmons, J.; Dubinskii, M.] USA, Res Lab, RDRL SEE O, Adelphi, MD 20783 USA. RP Dubinskii, M (reprint author), USA, Res Lab, RDRL SEE O, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM mdubinskiy@arl.army.mil NR 13 TC 19 Z9 19 U1 1 U2 14 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 1612-2011 EI 1612-202X J9 LASER PHYS LETT JI Laser Phys. Lett. PD MAR PY 2010 VL 7 IS 3 BP 206 EP 209 DI 10.1002/lapl.200910132 PG 4 WC Optics; Physics, Applied SC Optics; Physics GA 568MC UT WOS:000275525500005 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI America's Captives: Treatment of POWs from the Revolutionary War to the War on Terror SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combines Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combines Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD MAR 1 PY 2010 VL 135 IS 4 BP 90 EP 90 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 565EW UT WOS:000275273000123 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI The Enemy in Our Hands: America's Treatment of Prisoners of War from the Revolution to the War on Terror SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD MAR 1 PY 2010 VL 135 IS 4 BP 90 EP 90 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 565EW UT WOS:000275273000122 ER PT J AU Kondoh, K Hamada, ESA Imai, H Umeda, J Jones, T AF Kondoh, Katsuyoshi Hamada, El-Sayed Ayman Imai, Hisashi Umeda, Junko Jones, Tyrone TI Microstructures and mechanical responses of powder metallurgy non-combustive magnesium extruded alloy by rapid solidification process in mass production SO MATERIALS & DESIGN LA English DT Article ID CAST MG; BEHAVIOR; TEMPERATURE; EXTRUSION; STRENGTH AB Spinning Water Atomization Process (SWAP), which was one of the rapid solidification processes, promised to produce coarse non-combustible magnesium alloy powder with 1-4 mm length, having fine alpha-Mg grains and Al(2)Ca intermetallic compounds. It had economical and safe benefits in producing coarse Mg alloy powders with very fine microstructures in the mass production process due to its extreme high solidification rate compared to the conventional atomization process. AMX602 (Mg-6%Al-0.5%Mn-2%Ca) powders were compacted at room temperature. Their green compacts with a relative density of about 85% were heated at 573-673 K for 300 s in Ar gas atmosphere, and immediately consolidated by hot extrusion. Microstructure observation and evaluation of mechanical properties of the extruded AMX602 alloys were carried out. The uniform and fine microstructures with grains less than 0.45-0.8 mu m via dynamic recrystallization during hot extrusion were observed, and were much small compared to the extruded AMX602 alloy fabricated by using cast ingot. The extremely fine intermetallic compounds 200-500 nm diameter were uniformly distributed in the matrix of powder metallurgy (P/M) extruded alloys. These microstructures caused excellent mechanical properties of the wrought alloys. For example, in the case of AMX602 alloys extruded at 573 K, the tensile strength (TS) of 447 MPa, yield stress (YS) of 425 MlPa and 9.6% elongation were obtained. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved. C1 [Kondoh, Katsuyoshi; Hamada, El-Sayed Ayman; Imai, Hisashi; Umeda, Junko] Osaka Univ, Joining & Welding Res Inst, Osaka 5670047, Japan. [Jones, Tyrone] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Kondoh, K (reprint author), Osaka Univ, Joining & Welding Res Inst, 11-1 Mihogaoka, Osaka 5670047, Japan. EM kondoh@jwri.osaka-u.ac.jp OI Elsayed, Ayman/0000-0002-1116-5527 NR 23 TC 11 Z9 12 U1 3 U2 17 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0261-3069 J9 MATER DESIGN JI Mater. Des. PD MAR PY 2010 VL 31 IS 3 BP 1540 EP 1546 DI 10.1016/j.matdes.2009.10.001 PG 7 WC Materials Science, Multidisciplinary SC Materials Science GA 551JE UT WOS:000274203200061 ER PT J AU Stephenson, LD Bailey, D Kumar, A Hock, V AF Stephenson, L. D. Bailey, David Kumar, Ashok Hock, Vincent TI Polyurea Coatings for Rehabilitation of Metal Roofing SO MATERIALS PERFORMANCE LA English DT Article AB Higb-build plural-component polyurea-hybrid spray-on coatings quickly and cost-effectively rehabilitate metal roofs. A badly degraded aluminum alloy roof at an Army airfield was chosen for rehabilitation. The polyurea-hybrid coating was economical to apply, and is expected to the service life of the metal roof by providing a very tough moisture impermeable spray-on membrane. It effectively seals surface defects, even around penetrations, pinholes, and seams. C1 [Stephenson, L. D.; Bailey, David; Kumar, Ashok; Hock, Vincent] USA, ERDC, CERL, Champaign, IL 61826 USA. RP Stephenson, LD (reprint author), USA, ERDC, CERL, POB 9005, Champaign, IL 61826 USA. NR 9 TC 1 Z9 1 U1 1 U2 14 PU NATL ASSOC CORROSION ENG PI HOUSTON PA 1440 SOUTH CREEK DRIVE, HOUSTON, TX 77084-4906 USA SN 0094-1492 J9 MATER PERFORMANCE JI Mater. Perform. PD MAR PY 2010 VL 49 IS 3 BP 47 EP 53 PG 7 WC Materials Science, Characterization & Testing SC Materials Science GA 570TW UT WOS:000275702000012 ER PT J AU Marr, LC Ely, MR AF Marr, Linsey C. Ely, Matthew R. TI Effect of Air Pollution on Marathon Running Performance SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE ATHLETIC PERFORMANCE; EXERCISE; LUNG FUNCTION; SEX; PM(10); WEATHER ID PULMONARY-FUNCTION; OZONE EXPOSURE; PARTICLE DEPOSITION; LUNG-FUNCTION; EXERCISE; ADULTS; NASAL; SCHOOLCHILDREN; DIOXIDE; OUTDOOR AB MARR, L. C. and M. R. ELY. Effect of Air Pollution on Marathon Running Performance. Med. Sci. Sports Exerc., Vol. 42, No. 3, pp. 585-591, 2010. Before the 2008 Olympic Games, there was concern that air pollution in Beijing would affect the performance of marathon runners. Air pollutant concentrations during marathon running and their effect on performance have not been reported. Evidence suggests that the lung function of females may be more susceptible than that of males to air pollution, but it is uncertain if this translates to decreased marathon performance. Purpose: The purposes of this study were to 1) describe ambient air pollutant concentrations present during major US marathons, 2) quantify performance decrements associated with air pollutants, and 3) examine potential sex difference in performance related to air pollutants. Methods: Marathon race results, weather data, and air pollutant concentrations were obtained for seven marathons for 8-28 yr. The top three male and female finishing times were compared with the course record and contrasted with air pollutant levels and wet bulb globe temperature (WBGT). A WBGT-adjusted performance decrement was calculated, and regression analysis was used to quantify performance decrements associated with pollutants. Results: The air pollutant concentrations of carbon monoxide, ozone, particulate matter smaller than 10 mu m (PM(10)), PM(2.5), nitrogen dioxide, and sulfur dioxide ranged from 0 to 5.9 ppm, from 0 to 0.07 ppm, from 4.5 to 41.0 mu g.m(-3), from 2.8 to 42.0 mu g.m(-3), from 0 to 0.06 ppm, and from 0 to 0.05 ppm, respectively. After adjusting for WBGT-associated performance decrements, only PM(10) was associated with decrements in performance of women. For every 10-mu g.m(-3) increase in PM(10), performance can be expected to decrease by 1.4%. Conclusions: The concentrations of air pollution present during marathons rarely exceed health-based national standards and levels known to affect lung function in laboratory situations. Regardless, PM(10) was significantly correlated with performance of women marathon runners. C1 [Marr, Linsey C.] Virginia Tech, Dept Civil & Environm Engn, Blacksburg, VA 24061 USA. [Ely, Matthew R.] USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Marr, LC (reprint author), Virginia Tech, Dept Civil & Environm Engn, 411 Durham Hall 0246, Blacksburg, VA 24061 USA. EM lmarr@vt.edu RI Marr, Linsey/C-9698-2010; Lucas, Elizabeth/E-2733-2010; OI Marr, Linsey/0000-0003-3628-6891; Ely, Matthew/0000-0002-0618-7078 FU National Science Foundation's Advance program at Virginia Tech FX This work was supported by the National Science Foundation's Advance program at Virginia Tech. The authors thank TSgt Michael Ross (AFCCC), Jack Fleming (Boston Athletic Association), Shane Bauer (Grandma's Marathon), Will Nicholson (MS4 University of Minnesota Medical School), Myles Killar (Virginia Tech), and Nick Mangus (US EPA) for their assistance.; The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or reflecting the views of the Army or the Department of Defense. Any citations of commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement or approval of the products or services of these organizations. The authors do not have any relationships to disclose that would cause a conflict of interests. The results of the present study do not constitute endorsement by the American College of Sports Medicine. NR 38 TC 19 Z9 20 U1 7 U2 32 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAR PY 2010 VL 42 IS 3 BP 585 EP 591 DI 10.1249/MSS.0b013e3181b84a85 PG 7 WC Sport Sciences SC Sport Sciences GA 565VY UT WOS:000275324600025 PM 19952812 ER PT J AU Mirotznik, MS Good, B Ransom, P Wikner, D Mait, JN AF Mirotznik, Mark S. Good, Brandon Ransom, Paul Wikner, David Mait, Joseph N. TI ITERATIVE DESIGN OF MOTH-EYE ANTIREFLECTIVE SURFACES AT MILLIMETER WAVE FREQUENCIES SO MICROWAVE AND OPTICAL TECHNOLOGY LETTERS LA English DT Article DE diffractive; subwavelength; antireflective; millimeter wave; motheye ID BINARY GRATINGS; BAND AB A method for synthesizing broadband antireflective (AR) surfaces at millimeter wave frequencies is demonstrated AR surfaces were formed by machining a multilayer subwavelength structures Into nonabsorptive dielectrics. This created low-reflected energies (<-25 dB) over large bandwidths and incidence angles Experimental results are provided demonstrating the validity of the method. (C) 2010 Wiley Periodicals, Inc Microwave Opt Technol Lett 52 561-568, 2010. Published online in Wiley InterScience (www.interscience.wiley.com) DOI 10.1002/mop.24973 C1 [Mirotznik, Mark S.; Good, Brandon] Catholic Univ Amer, Dept Elect Engn & Comp Sci, Washington, DC 20064 USA. [Ransom, Paul] USN, Ctr Surface Warfare, Carderock Div, Bethesda, MD 20817 USA. [Wikner, David; Mait, Joseph N.] USA, Res Lab, Adelphi, MD 20783 USA. RP Mirotznik, MS (reprint author), Catholic Univ Amer, Dept Elect Engn & Comp Sci, 620 Michigan Ave NE, Washington, DC 20064 USA. NR 15 TC 3 Z9 3 U1 1 U2 10 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0895-2477 J9 MICROW OPT TECHN LET JI Microw. Opt. Technol. Lett. PD MAR PY 2010 VL 52 IS 3 BP 561 EP 568 DI 10.1002/mop.24973 PG 8 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA 553JW UT WOS:000274363700018 ER PT J AU Breloski, JT AF Breloski, Jeffrey T. TI "SOS": SAVE OUR SERVICE MARKS SO MILITARY LAW REVIEW LA English DT Article C1 USA, Cent Command, Ft McPherson, GA USA. RP Breloski, JT (reprint author), USA, Cent Command, Ft McPherson, GA USA. NR 19 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 2010 VL 203 BP 78 EP 148 PG 71 WC Law SC Government & Law GA 635KF UT WOS:000280653300002 ER PT J AU Gregory, EJ AF Gregory, E. John TI TRYING UNLAWFUL COMBATANTS AT GENERAL COURTS-MARTIAL: AMENDING THE UCMJ IN LIGHT OF THE MILITARY COMMISSIONS EXPERIENCE SO MILITARY LAW REVIEW LA English DT Article ID TERRORISM; DETENTION C1 [Gregory, E. John] USA, Washington, DC 20310 USA. RP Gregory, EJ (reprint author), US Forces Iraq, Victory Base Complex, Baghdad, Iraq. NR 38 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 2010 VL 203 BP 150 EP 188 PG 39 WC Law SC Government & Law GA 635KF UT WOS:000280653300003 ER PT J AU Borch, FL AF Borch, Fred L., III TI THE HISTORY OF "DON'T ASK, DON'T TELL" IN THE ARMY: HOW WE GOT TO IT AND WHY IT IS WHAT IT IS SO MILITARY LAW REVIEW LA English DT Article ID POLICY RP Borch, FL (reprint author), USA, Judge Advocate Gens Corps, Judge Advocate Gens Legal Ctr & Sch TJAGLCS, Charlottesville, VA USA. NR 35 TC 3 Z9 3 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 2010 VL 203 BP 189 EP 206 PG 18 WC Law SC Government & Law GA 635KF UT WOS:000280653300004 ER PT J AU Bunn, SA AF Bunn, Sherilyn A. TI STRAIGHT TALK: THE IMPLICATIONS OF REPEALING "DON'T ASK, DON'T TELL" AND THE RATIONALE FOR PRESERVING ASPECTS OF THE CURRENT POLICY SO MILITARY LAW REVIEW LA English DT Article ID MEN C1 USA, Judge Advocate Officer Grad Course 58, Judge Advocate Gens Legal Ctr & Sch, Charlottesville, VA USA. RP Bunn, SA (reprint author), USA, Judge Advocate Officer Grad Course 58, Judge Advocate Gens Legal Ctr & Sch, Charlottesville, VA USA. NR 106 TC 6 Z9 6 U1 0 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 2010 VL 203 BP 207 EP 283 PG 77 WC Law SC Government & Law GA 635KF UT WOS:000280653300005 ER PT J AU Kesler, LR AF Kesler, Laura R. TI SERVING WITH INTEGRITY: THE RATONALE FOR THE REPEAL OF "DON'T ASK, DON'T TELL" AND ITS BAN ON ACKNOWLEDGED HOMOSEXUALS IN THE ARMED FORCES SO MILITARY LAW REVIEW LA English DT Article ID UNITED-STATES; MILITARY; INTEGRATION; WOMEN C1 USA, Judge Advocate Officer Grad Course 58, Judge Advocate Gens Sch, Charlottesville, VA USA. RP Kesler, LR (reprint author), USA, Judge Advocate Officer Grad Course 58, Judge Advocate Gens Sch, Charlottesville, VA USA. NR 156 TC 5 Z9 5 U1 0 U2 4 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 2010 VL 203 BP 284 EP 380 PG 97 WC Law SC Government & Law GA 635KF UT WOS:000280653300006 ER PT J AU Bedno, SA Lang, CE Daniell, WE Wiesen, AR Datu, B Niebuhr, DW AF Bedno, Sheryl A. Lang, Christine E. Daniell, William E. Wiesen, Andrew R. Datu, Bennett Niebuhr, David W. TI Association of Weight at Enlistment With Enrollment in the Army Weight Control Program and Subsequent Attrition in the Assessment of Recruit Motivation and Strength Study SO MILITARY MEDICINE LA English DT Article ID STATE-SPECIFIC PREVALENCE; UNITED-STATES; OBESITY; ADULTS; OVERWEIGHT; MILITARY AB The ongoing obesity epidemic has made recruiting qualified Army applicants increasingly difficult. A cohort of 10,213 Army enlisted subjects was enrolled in the Assessment of Recruit Motivation and Strength (ARMS) study from February 2005 through September 2006. Overweight recruits obtained a waiver for enlistment (n = 990) if they passed a screening physical fitness test. Recruits were evaluated for enrollment into the Army Weight Control Program (AWCP) and discharged during the 15 months following enlistment. Enrollment was higher among overweight recruits than recruits who met entrance standards (men: adjusted OR = 13.3 [95% CI: 10.3, 17.2]; women: adjusted OR = 3.6 [3.3, 3.9]). Although the discharge frequency was higher in the waiver group than in those who met standards (25.4% versus 19.9%, p < 0.001), there were only 10 (0.5% of total) discharges directly attributed to weight. Granting overweight waivers through the ARMS program increases enrollment to the AWCP but has little effect on weight-related attrition. C1 [Bedno, Sheryl A.; Datu, Bennett; Niebuhr, David W.] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD 20910 USA. [Lang, Christine E.; Wiesen, Andrew R.] Madigan Army Med Ctr, ATTN MCHJ PV, Tacoma, WA 98431 USA. [Daniell, William E.] Univ Washington, Sch Publ Hlth, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA. RP Bedno, SA (reprint author), Walter Reed Army Inst Res, Div Prevent Med, 503 Robert Grant Rd, Silver Spring, MD 20910 USA. FU U.S. Army Accession Command FX This study was funded by the U.S. Army Accession Command. NR 14 TC 8 Z9 8 U1 1 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2010 VL 175 IS 3 BP 188 EP 193 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 582GT UT WOS:000276585400012 PM 20358709 ER PT J AU Magee, CD Moawad, FJ Moses, F AF Magee, Charles D. Moawad, Fouad J. Moses, Frank TI NO-Xplode: A Case of Supplement-Associated Ischemic Colitis SO MILITARY MEDICINE LA English DT Article ID NITRIC-OXIDE; L-ARGININE; EXERCISE; HUMANS; RUNNERS AB The most common cause of ischemic colitis (IC) is a sudden and transient reduction in splanchnic perfusion. In the younger population, medications are an increasingly recognized cause of ischemic bowel disease. Over-the-counter supplements may also lead to the development of ischemic colitis through similar effects. We present a case of ischemic colitis in a 42-year-old active duty service member after using the performance-enhancing supplement, NO-Xplode. In this report, we review the pharmacology of this supplement and its proposed mechanism of injury. C1 [Magee, Charles D.] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. [Moawad, Fouad J.; Moses, Frank] Walter Reed Army Med Ctr, Gastroenterol Serv, Washington, DC 20307 USA. RP Magee, CD (reprint author), Walter Reed Army Med Ctr, Dept Med, 6900 Georgia Ave, Washington, DC 20307 USA. NR 20 TC 7 Z9 7 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2010 VL 175 IS 3 BP 202 EP 205 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 582GT UT WOS:000276585400015 PM 20358712 ER PT J AU Alosh, M AF Alosh, Mahdi TI Advanced Media Arabic SO MODERN LANGUAGE JOURNAL LA English DT Book Review C1 [Alosh, Mahdi] US Mil Acad, West Point, NY 10996 USA. RP Alosh, M (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0026-7902 J9 MOD LANG J JI Mod. Lang. J. PD SPR PY 2010 VL 94 IS 1 BP 159 EP 160 PG 2 WC Education & Educational Research; Linguistics SC Education & Educational Research; Linguistics GA 552AY UT WOS:000274258900019 ER PT J AU Sherman, LS Blum, JD Johnson, KP Keeler, GJ Barres, JA Douglas, TA AF Sherman, Laura S. Blum, Joel D. Johnson, Kelsey P. Keeler, Gerald J. Barres, James A. Douglas, Thomas A. TI Mass-independent fractionation of mercury isotopes in Arctic snow driven by sunlight SO NATURE GEOSCIENCE LA English DT Article ID HEAVY-ELEMENTS; CANADA; REDUCTION; ALERT; SPRINGTIME; DEPOSITION; CHEMISTRY; SNOWPACKS; SYSTEMS; HG(II) AB After polar sunrise in the Arctic, sunlight-induced reactions convert gaseous elemental mercury into compounds that are rapidly deposited to the snowpack. These atmospheric mercury depletion events occur repeatedly until snowmelt(1,2). Following deposition, the mercury can be reduced by sunlight-induced reactions and emitted as a gas(3-6), or can be retained in the snowpack(7,8), where it may affect Arctic ecosystems following snowmelt. However, the proportion of mercury that remains in the snowpack is uncertain. Here, we measured the mercury isotopic composition of snow samples collected during an atmospheric mercury depletion event in Barrow, Alaska. We report large negative mass-independent fractionation of mercury isotopes in the Arctic snow. Results from a flux chamber experiment suggest that mass-independent fractionation is coupled to the re-emission of elemental mercury to the atmosphere, and is triggered by sunlight-induced reactions. On the basis of the above, we estimate that photochemical reactions triggered the release of a significant portion of the mercury deposited during this atmospheric mercury depletion event. C1 [Sherman, Laura S.; Blum, Joel D.; Johnson, Kelsey P.] Univ Michigan, Dept Geol Sci, Ann Arbor, MI 48109 USA. [Keeler, Gerald J.; Barres, James A.] Univ Michigan, Air Qual Lab, Ann Arbor, MI 48109 USA. [Douglas, Thomas A.] Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. RP Sherman, LS (reprint author), Univ Michigan, Dept Geol Sci, 1100 N Univ Ave, Ann Arbor, MI 48109 USA. EM lsaylors@umich.edu FU National Science Foundation Office of Polar Programs [ARC-0435989, ARC-0435893]; National Defense Science and Engineering Graduate Fellowship through the Department of Defense, Office of Naval Research FX Financial support for this research was provided by the National Science Foundation Office of Polar Programs (Grants ARC-0435989 and ARC-0435893). L. S. S. is financially supported by a National Defense Science and Engineering Graduate Fellowship through the Department of Defense, Office of Naval Research. We are grateful to M. W. Johnson, L. Alvarez-Aviles, M. Sturm, R. Prevost, P. W. Sherman and the members of BEIGL for assistance and helpful discussions. NR 30 TC 98 Z9 105 U1 7 U2 53 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1752-0894 J9 NAT GEOSCI JI Nat. Geosci. PD MAR PY 2010 VL 3 IS 3 BP 173 EP 177 DI 10.1038/NGEO758 PG 5 WC Geosciences, Multidisciplinary SC Geology GA 561KF UT WOS:000274974700017 ER PT J AU Satirapoj, B Supasyndh, O Chaiprasert, A Ruangkanchanasetr, P Kanjanakul, I Phulsuksombuti, D Utainam, D Choovichian, P AF Satirapoj, Bancha Supasyndh, Ouppatham Chaiprasert, Amnart Ruangkanchanasetr, Prajej Kanjanakul, Inseey Phulsuksombuti, Duangporn Utainam, Darunee Choovichian, Panbuppa TI Relationship between serum uric acid levels with chronic kidney disease in a Southeast Asian population SO NEPHROLOGY LA English DT Article DE chronic kidney disease; glomerular filtration rate; hyperuricaemia ID RENAL-DISEASE; RISK-FACTORS; PROGRESSION; HYPERURICEMIA; GOUT; PREDICTORS; COHORT; RATS AB Aim: Elevated serum uric level has been suggested as a risk factor for chronic kidney disease (CKD). The relationship between serum uric acid level, and CKD in a Southeast Asian population was examined. Methods: In a cross-sectional study, authors surveyed 5618 subjects, but 5546 participants were included. The glomerular filtration rate (GFR) values were calculated by the Modification of Diet in Renal Disease (MDRD) equation. CKD was defined as a GFR of less than 60 mL/min per 1.73 m(2). Multivariate binary logistic regression was used to determine the association between serum uric acid level and CKD. Results: The prevalence of CKD in serum uric acid quartiles: first quartile, 5.3 mg/dL or less; second quartile, 5.4-6.4 mg/dL; third quartile, 6.5-7.6 mg/dL; and fourth quartile, 7.7 mg/dL or more were 1.8%, 3.6%, 5.5% and 11.9%, respectively (P < 0.001). The mean values of estimated GFR in participants with CKD and without CKD were 53.44 +/- 7.72 and 81.26 +/- 12.48 mL/min per 1.73 m(2) respectively. In the entire participants, there were 6.76% with hypertension and 2.64% with diabetes as a comorbid disease. Compared with serum uric acid first quartile, the multivariate-adjusted odds for CKD of the fourth, third and second quartile were 10.94 (95% confidence interval (CI), 6.62-16.08), 4.17 (95% CI, 2.51-6.92) and 2.38 (95% CI, 1.43-3.95), respectively. Conclusion: High serum uric acid level was independently associated with increased prevalence of CKD in the Southeast Asian population. Detection and treatment of hyperuricaemia should be attended as a strategy to prevent CKD. C1 [Satirapoj, Bancha; Supasyndh, Ouppatham; Chaiprasert, Amnart; Ruangkanchanasetr, Prajej; Kanjanakul, Inseey; Choovichian, Panbuppa] Phramongkutklao Hosp, Dept Med, Div Nephrol, Bangkok 10400, Thailand. [Satirapoj, Bancha; Supasyndh, Ouppatham; Chaiprasert, Amnart; Ruangkanchanasetr, Prajej; Kanjanakul, Inseey; Choovichian, Panbuppa] Coll Med, Bangkok, Thailand. [Phulsuksombuti, Duangporn; Utainam, Darunee] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Satirapoj, B (reprint author), Phramongkutklao Hosp, Dept Med, Div Nephrol, Bangkok 10400, Thailand. EM satirapoj@yahoo.com FU Department of Medicine, Phramongkutklao Hospital FX The authors wish to acknowledge Sharon Adler, MD, for helpful suggestions and Miss Dollapas Punpanich for statistical analysis. This study was supported by a grant from the Department of Medicine, Phramongkutklao Hospital. NR 19 TC 11 Z9 15 U1 1 U2 3 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1320-5358 J9 NEPHROLOGY JI Nephrology PD MAR PY 2010 VL 15 IS 2 BP 253 EP 258 DI 10.1111/j.1440-1797.2009.01179.x PG 6 WC Urology & Nephrology SC Urology & Nephrology GA 564IQ UT WOS:000275206900019 PM 20470288 ER PT J AU Loh, Y Swanberg, MM Ingram, MV Newmark, J AF Loh, Yince Swanberg, Margaret M. Ingram, M. Victoria Newmark, Jonathan TI Case report: Long-term cognitive sequelae of sarin exposure SO NEUROTOXICOLOGY LA English DT Article DE Sarin; Neurocognition; Neuropsychological; Organophosphate; Weaponized ID US ARMY VETERANS; 1991 GULF-WAR; BRAIN; RATS; CYCLOSARIN; INHALATION; MARMOSET; MONKEYS AB The long-term sequelae of acute satin exposure are not well understood. The largest clinical cohort resulted from the 1994 and 1995 attacks in Japan. Observers noted mostly psychiatric sequelae, with a high prevalence of post-traumatic stress disorder (PTSD). We describe neurocognitive findings that may represent sequelae of low-level sarin exposure in Iraq. Published by Elsevier Inc. C1 [Loh, Yince] Madigan Army Med Ctr, Neurol Sect, Dept Med, Tacoma, WA 98431 USA. [Swanberg, Margaret M.] Walter Reed Army Med Ctr, Dept Neurol, Washington, DC 20307 USA. [Ingram, M. Victoria] Womack Army Med Ctr, Psychol Serv, Ft Bragg, NC 28310 USA. [Newmark, Jonathan] USA, Med Res Inst Chem Def, Chem Casualty Care Div, Aberdeen Proving Ground, MD 21010 USA. RP Loh, Y (reprint author), Madigan Army Med Ctr, Neurol Sect, Dept Med, Bldg 9040,Fitzsimmons Dr, Tacoma, WA 98431 USA. EM yincer@yahoo.com NR 17 TC 7 Z9 7 U1 0 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0161-813X J9 NEUROTOXICOLOGY JI Neurotoxicology PD MAR PY 2010 VL 31 IS 2 BP 244 EP 246 DI 10.1016/j.neuro.2009.12.004 PG 3 WC Neurosciences; Pharmacology & Pharmacy; Toxicology SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology GA 574KF UT WOS:000275987300010 PM 20036279 ER PT J AU Leinweber, G Barry, DP Burke, JA Drindak, NJ Danon, Y Block, RC Francis, NC Moretti, BE AF Leinweber, G. Barry, D. P. Burke, J. A. Drindak, N. J. Danon, Y. Block, R. C. Francis, N. C. Moretti, B. E. TI Resonance Parameters and Uncertainties Derived from Epithermal Neutron Capture and Transmission Measurements of Natural Molybdenum SO NUCLEAR SCIENCE AND ENGINEERING LA English DT Article ID RADIATIVE CAPTURE AB The electron linear accelerator facility at the Rensselaer Polytechnic Institute was used to explore neutron interactions with molybdenum in the energy region from 10 eV to 2 keV. Neutron capture and transmission measurements were performed by the time-of-flight technique. Resonance parameters were extracted from the data using the multilevel R-matrix Bayesian code SAMMY. A table of resonance parameters and their uncertainties is presented. Two transmission measurements were performed at a flight path of 25 in with a (6)Li glass scintillation detector. The neutron capture measurements were performed at a flight path of 25 m with a 16-segment sodium iodide multiplicity detector. Nine different thicknesses of elemental molybdenum metal samples ranging from 0.051 mm (0.002 in.) to 6.35 mm (0.250 in.) were measured in either capture or transmission. Reductions in resonance integrals were observed when compared to ENDF/B-VII.0 for six of the seven stable isotopes. The largest reductions were 9% in (97)Mo and 11% in (100)Mo. The one measured increase in resonance integral relative to ENDF/B-VII.0 occurred in (95)Mo, and it was significant (10%). The measured distribution of neutron widths for (95)Mo and (97)Mo are a better match to a Porter-Thomas distribution than those of ENDF/B-VII.0. Neutron strength functions for (95)Mo and (97)Mo were measured and compared to ENDF/B-VII.0. The strength of (95)Mo and (97)Mo are within uncertainties of each other. The measured radiation width distribution for (95)Mo and (97)Mo are compared to those of ENDF/B-VII.0 and to chi(2) distributions. Significant aspects of this analysis are the assignment of radiation widths, the determination of the transmission resolution function, and the propagation of experimental uncertainties into resonance parameter uncertainties. C1 [Leinweber, G.; Barry, D. P.; Burke, J. A.; Drindak, N. J.] Bechtel Marine Prop Corp, Knolls Atom Power Lab, Schenectady, NY 12301 USA. [Danon, Y.; Block, R. C.; Francis, N. C.] Rensselaer Polytech Inst, Dept Mech Aerosp & Nucl Engn, Troy, NY 12180 USA. [Moretti, B. E.] US Mil Acad, Dept Phys, West Point, NY 10996 USA. RP Leinweber, G (reprint author), Bechtel Marine Prop Corp, Knolls Atom Power Lab, POB 1072, Schenectady, NY 12301 USA. EM leinwg@rpi.edu NR 22 TC 8 Z9 8 U1 0 U2 2 PU AMER NUCLEAR SOC PI LA GRANGE PK PA 555 N KENSINGTON AVE, LA GRANGE PK, IL 60526 USA SN 0029-5639 J9 NUCL SCI ENG JI Nucl. Sci. Eng. PD MAR PY 2010 VL 164 IS 3 BP 287 EP 303 PG 17 WC Nuclear Science & Technology SC Nuclear Science & Technology GA 600US UT WOS:000278015000005 ER PT J AU Fernandes, GE Kim, JH Liu, ZJ Shainline, J Osgood, R Xu, J AF Fernandes, Gustavo E. Kim, Jin Ho Liu, Zhijun Shainline, Jeffrey Osgood, Richard, III Xu, Jimmy TI Using a forest of gold nanowires to reduce the reflectivity of silicon SO OPTICAL MATERIALS LA English DT Article DE Metamaterials; Energy harvesting; Silicon photovoltaics; Porous alumina; Anti-reflection coatings; Optical filters ID INFRARED-ABSORPTION; FABRICATION; SURFACE; SIZE AB The optical reflectivity of polished silicon covered by a forest of vertically standing gold nanowires (grown inside the pores of an anodic alumina matrix) is found to be considerably smaller than that of bare polished silicon and strongly influenced by scattering of light by the nanowires. We propose a phenomenological modification to the Maxwell-Garnett effective medium theory formula to account for this effect. We also find that the gold nanowire/alumina film has interesting optical properties, such as transparency in the mid-infrared and high absorbance in the visible, and may be used as a low reflectivity coating and a low-pass filter. (c) 2010 Elsevier B.V. All rights reserved. C1 [Fernandes, Gustavo E.; Kim, Jin Ho; Liu, Zhijun; Xu, Jimmy] Brown Univ, Div Engn, Providence, RI 02912 USA. [Shainline, Jeffrey; Xu, Jimmy] Brown Univ, Dept Phys, Providence, RI 02912 USA. [Osgood, Richard, III] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Fernandes, GE (reprint author), Brown Univ, Div Engn, Box D, Providence, RI 02912 USA. EM Gustavo_Fernandes@Brown.edu FU AFOSR; ARO; Seoul National University FX This work was supported in part by AFOSR, ARO, and by the WCU program of Seoul National University. NR 19 TC 7 Z9 7 U1 1 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0925-3467 J9 OPT MATER JI Opt. Mater. PD MAR PY 2010 VL 32 IS 5 BP 623 EP 626 DI 10.1016/j.optmat.2009.12.010 PG 4 WC Materials Science, Multidisciplinary; Optics SC Materials Science; Optics GA 569OA UT WOS:000275605600011 ER PT J AU Roppo, V Wang, W Kalinowski, K Kong, Y Cojocaru, C Trull, J Vilaseca, R Scalora, M Krolikowski, W Kivshar, Y AF Roppo, V. Wang, W. Kalinowski, K. Kong, Y. Cojocaru, C. Trull, J. Vilaseca, R. Scalora, M. Krolikowski, W. Kivshar, Yu. TI The role of ferroelectric domain structure in second harmonic generation in random quadratic media SO OPTICS EXPRESS LA English DT Article ID STRONTIUM-BARIUM NIOBATE; HARMONIC-GENERATION; 3RD-HARMONIC GENERATION; NONLINEAR CRYSTALS; FORCE MICROSCOPE; SINGLE-CRYSTALS; LASER CRYSTAL; SCATTERING; LIGHT; SR0.61BA0.39NB2O6 AB We study theoretically and numerically the second harmonic generation in a nonlinear crystal with random distribution of ferroelectric domains. We show that the specific features of disordered domain structure greatly affect the emission pattern of the generated harmonics. This phenomena can be used to characterize the degree of disorder in nonlinear photonic structures. (C) 2010 Optical Society of America C1 [Roppo, V.; Cojocaru, C.; Trull, J.; Vilaseca, R.] Univ Politecn Cataluna, Dept Fis & Engn Nucl, ETSEIAT, Barcelona 08222, Spain. [Roppo, V.; Wang, W.; Kalinowski, K.; Krolikowski, W.; Kivshar, Yu.] Australian Natl Univ, Nonlinear Phys Ctr, Canberra, ACT 0200, Australia. [Roppo, V.; Wang, W.; Kalinowski, K.; Krolikowski, W.; Kivshar, Yu.] Australian Natl Univ, Res Sch Phys & Engn, Laser Phys Ctr, Canberra, ACT 0200, Australia. [Wang, W.; Kong, Y.] Nankai Univ, Coll Phys Sci, Tianjin 300071, Peoples R China. [Scalora, M.] USA, Charles M Bowden Res Facil, RDECOM, Aviat & Missile Command, Redstone Arsenal, AL 35803 USA. RP Roppo, V (reprint author), Univ Politecn Cataluna, Dept Fis & Engn Nucl, ETSEIAT, Colom 11, Barcelona 08222, Spain. RI Kong, Yongfa/A-1238-2009; Krolikowski, wieslaw/A-7083-2011; roppo, vito/D-9639-2012; Trull, Jose/L-9054-2014; OI roppo, vito/0000-0003-0928-4209; Trull, Jose/0000-0002-5850-088X; Vilaseca, Ramon/0000-0002-3736-5789 FU Australian Research Council; Spanish Government [FIS2008-06024-C03-02]; Catalan Government [2009 SGR 1168, BE 2009]; COST Action [MP0702] FX This work was supported by the Australian Research Council, Spanish Government (FIS2008-06024-C03-02), Catalan Government (2009 SGR 1168 and BE 2009) and the COST Action MP0702. V. R. thanks Cristian Ciraci for helpful discussions and suggestions with the images. The authors thank D. Neshev for collaboration. NR 36 TC 10 Z9 10 U1 0 U2 6 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD MAR 1 PY 2010 VL 18 IS 5 BP 4012 EP 4022 DI 10.1364/OE.18.004012 PG 11 WC Optics SC Optics GA 567NO UT WOS:000275454100080 PM 20389416 ER PT J AU Kantanen, DJ Closmann, JJ Rowshan, HH AF Kantanen, Dennis J. Closmann, James J. Rowshan, Henry H. TI Abdominal fat harvest technique and its uses in maxillofacial surgery SO ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY LA English DT Article ID GRAFT AB Abdominal fat harvest and augmentation to the maxillofacial region is a relatively inexpensive, safe, and readily available procedure. The use of abdominal fat free transfer has been well documented for cosmetic, trauma, and temporomandibular joint reconstruction. Fat is the closest we have to an ideal filler, it is readily available and inexpensive, it is autologous and therefore lacks a host immune response, it is safe and noncarcinogenic, and it is easily acquired with a minimally invasive procedure. Abdominal fat donor site is the most commonly used owing to ease of access and availability of fat stores. Complications are rare and easily managed in the office. Free abdominal fat harvest is a predictable surgical technique that allows the maxillofacial surgeon access to autologous graft material that is ideal for multiple facial procedures. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109: 367-371) C1 [Kantanen, Dennis J.; Closmann, James J.; Rowshan, Henry H.] Tripler Army Med Ctr, Div Oral & Maxillofacial Surg, Honolulu, HI 96859 USA. RP Kantanen, DJ (reprint author), Tripler Army Med Ctr, Div Oral & Maxillofacial Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM dkantanen@hotmail.com NR 15 TC 9 Z9 9 U1 1 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 1079-2104 J9 ORAL SURG ORAL MED O JI Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. PD MAR PY 2010 VL 109 IS 3 BP 367 EP 371 DI 10.1016/j.tripleo.2009.09.037 PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 561DT UT WOS:000274956600009 PM 20060341 ER PT J AU Robitschek, J Straub, M Wirtz, E Klem, C Sniezek, J AF Robitschek, Jon Straub, Mary Wirtz, Eric Klem, Christopher Sniezek, Joseph TI Diagnostic efficacy of surgeon-performed ultrasound-guided fine needle aspiration: A randomized controlled trial SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article ID BIOPSY; MASSES; HEAD AB OBJECTIVE: To evaluate the clinical efficacy of surgeon-performed, office-based head and neck ultrasound in facilitating diagnostic fine needle aspiration (FNA) of lesions in the head and neck. STUDY DESIGN: A randomized controlled trial of ultrasound-guided FNA versus traditional palpation-guided technique for palpable masses in the head and neck. SETTING: An office-based study performed in a military academic medical center. SUBJECTS AND METHODS: Eighty-one adults older than 18 years of age with a palpable head and neck mass (less than 3 cm in largest diameter) were randomized to ultrasound-guided or traditional palpation-guided FNA of a head and neck mass. Measured variables and outcomes for the study included tissue adequacy rates, tissue type, and operator variability. RESULTS: Following three passes using either palpation or ultrasound guidance, a comparative tissue adequacy rate of 84 percent for ultrasound guidance versus 58 percent for standard palpation was established (P < 0.014). With regard to tissue type, a statistically significant comparative diagnostic advantage for ultrasound guidance was observed in thyroid tissue while remaining statistically insignificant for lymphatic and salivary tissues. No statistical significance was found when comparing the ability of otolaryngology residents versus attending otolaryngologists to obtain ultrasound-guided diagnostic samples. CONCLUSION: Office-based surgeon-performed ultrasound-guided FNA of palpable lesions in the head and neck yields a statistically significant higher diagnostic rate compared to standard palpation technique. Our institutional experience supports the utility of surgeon-performed ultrasound as a core competency in clinical practice. (c) 2010 American Academy of Otolaryngology Head and Neck Surgery Foundation. All rights reserved. C1 [Robitschek, Jon; Straub, Mary; Wirtz, Eric; Klem, Christopher; Sniezek, Joseph] Tripler Army Med Ctr, Dept Otolaryngol, Honolulu, HI 96859 USA. RP Wirtz, E (reprint author), 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM eric.d.wirtz@us.army.mil FU AMEDD Advanced Medical Technology Initiative Grant FX This study was supported by the AMEDD Advanced Medical Technology Initiative Grant (funding helped to provide equipment for collection of data). NR 7 TC 17 Z9 19 U1 0 U2 2 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD MAR PY 2010 VL 142 IS 3 BP 306 EP 309 DI 10.1016/j.otohns.2009.11.011 PG 4 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 582DA UT WOS:000276574600002 PM 20172371 ER PT J AU Eckart, RE Gentlesk, PJ Shry, EA AF Eckart, Robert E. Gentlesk, Philip J. Shry, Eric A. TI Differential Manifestation of Cardiovascular Complaints as a Function of Utilization of Ergogenic Supplements SO PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY LA English DT Article DE supplement use; syncope; palpitations ID ALTERNATIVE MEDICINE; DIAGNOSING SYNCOPE; DIETARY-SUPPLEMENT; YOUNG AB Introduction: The rate of use of dietary supplements among young adults is significant. While the military makes significant restrictions on the use of certain pharmacologic drugs and actively tests for illegal drugs in a deployed environment, there is a near-unlimited supply of body-enhancing supplements available at military exchanges to deployed personnel. By emphasizing physical performance and providing these for purchase, the military leadership, perhaps unknowingly, endorses the use of these products. Cardiovascular symptoms represent one of the leading nontraumatic causes of aeromedical evacuation from a combat zone. Whether the use of supplements is associated with a differential presentation to cardiovascular complaint is unknown. Methods: Retrospective review using the US Department of Defense Military Health System data, we identified patients evaluated for cardiovascular complaints of syncope or palpitations while deployed to Iraq and Afghanistan. Results: There were 905 US military personnel who presented with complaint of syncope or palpitations (mean age 31 +/- 10 years, 77% male). There were 83 (9.2%) who self-reported taking an ergogenic supplement. The incidence of reported use of supplements among males was 10.8%, which was significantly higher than its use among females at 3.8% (P = 0.001). In those > 30 years, those on supplements had a higher resting pulse (90 +/- 28 vs 79 +/- 24 beats/min, P = 0.032), and the incidence of resting tachycardia was three-fold higher (35.0% vs 11.4%, P = 0.008). Supplement use was seen in 12.3% of those who presented with palpitations, which was significantly higher than those who presented without palpitations (7.8%, P = 0.043). In those taking supplements, symptoms were more likely during exertion (26.5% vs 15.0%, P < 0.001), and immediately postexertional (13.2% vs 4.6%, P < 0.001). An electrocardiogram was suggestive of diagnosis in 103 (16.3%), while head computed tomography, treadmill, and echocardiogram had no diagnostic utility in this patient population. Discussion: In a healthy population serving within a combat zone, there exists a differential expression of disease in those taking supplements. Further study of a prospective nature to determine the impact of supplement use in this environment may allow for a more refined policy toward use and medical evaluation. (PACE 2010; 33:286-289) C1 [Eckart, Robert E.; Gentlesk, Philip J.] San Antonio Mil Med Ctr, San Antonio, TX USA. [Shry, Eric A.] Landstuhl Reg Med Ctr, Landstuhl, Germany. RP Eckart, RE (reprint author), Brooke Army Med Ctr, Arrhythmia Serv Cardiol MCHE MDC, Ft Sam Houston, TX 78234 USA. EM robert.eckart@us.army.mil NR 27 TC 4 Z9 4 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0147-8389 J9 PACE JI PACE-Pacing Clin. Electrophysiol. PD MAR PY 2010 VL 33 IS 3 BP 286 EP 289 DI 10.1111/j.1540-8159.2009.02610.x PG 4 WC Cardiac & Cardiovascular Systems; Engineering, Biomedical SC Cardiovascular System & Cardiology; Engineering GA 563DK UT WOS:000275107500007 PM 20015135 ER PT J AU Perez, C AF Perez, Celestino TI Killing in War SO PERSPECTIVES ON POLITICS LA English DT Book Review C1 [Perez, Celestino] USA, Command & Gen Staff Coll, Washington, DC 20310 USA. RP Perez, C (reprint author), USA, Command & Gen Staff Coll, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1537-5927 J9 PERSPECT POLIT JI Perspect. Polit. PD MAR PY 2010 VL 8 IS 1 BP 340 EP 343 PG 5 WC Political Science SC Government & Law GA 584CP UT WOS:000276727900064 ER PT J AU Perez, C AF Perez, Celestino TI How Do I Save My Honor? War, Moral Integrity, and Principled Resignation SO PERSPECTIVES ON POLITICS LA English DT Book Review C1 [Perez, Celestino] USA, Command & Gen Staff Coll, Washington, DC 20310 USA. RP Perez, C (reprint author), USA, Command & Gen Staff Coll, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 1 U2 1 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1537-5927 J9 PERSPECT POLIT JI Perspect. Polit. PD MAR PY 2010 VL 8 IS 1 BP 340 EP 343 PG 5 WC Political Science SC Government & Law GA 584CP UT WOS:000276727900063 ER PT J AU Foreman, JV Everitt, HO Yang, J McNicholas, T Liu, J AF Foreman, J. V. Everitt, H. O. Yang, J. McNicholas, T. Liu, J. TI Effects of reabsorption and spatial trap distributions on the radiative quantum efficiencies of ZnO SO PHYSICAL REVIEW B LA English DT Article ID ZINC-OXIDE; ABSORPTION; PHOSPHORS; CRYSTALS; SPECTRA; ENERGY AB Ultrafast time-resolved photoluminescence spectroscopy following one- and two-photon excitations of ZnO powder is used to gain unprecedented insight into the surprisingly high external quantum efficiency of its "green" defect emission band. The role of exciton diffusion, the effects of reabsorption, and the spatial distributions of radiative and nonradiative traps are comparatively elucidated for the ultraviolet excitonic and "green" defect emission bands in both unannealed nanometer-sized ZnO powders and annealed micrometer-sized ZnO:Zn powders. We find that the primary mechanism limiting quantum efficiency is surface recombination because of the high density of nonradiative surface traps in these powders. It is found that unannealed ZnO has a high density of bulk nonradiative traps as well, but the annealing process reduces the density of these bulk traps while simultaneously creating a high density of green-emitting defects near the particle surface. The data are discussed in the context of a simple rate equation model that accounts for the quantum efficiencies of both emission bands. The results indicate how defect engineering could improve the efficiency of ultraviolet-excited ZnO:Zn-based white light phosphors. C1 [Foreman, J. V.] Duke Univ, Dept Phys, Durham, NC 27708 USA. US Army Aviat & Missile Res, Ctr Dev & Engn, Redstone Arsenal, AL 35898 USA. [Yang, J.; McNicholas, T.; Liu, J.] Duke Univ, Dept Chem, Durham, NC 27708 USA. RP Foreman, JV (reprint author), Duke Univ, Dept Phys, Durham, NC 27708 USA. EM john.v.foreman@us.army.mil RI Everitt, Henry/L-7118-2013 OI Everitt, Henry/0000-0002-8141-3768 FU RDECOM/AMRDEC Competitive In-House Laboratory Independent Research (ILIR) FX This work was supported by RDECOM/AMRDEC Competitive In-House Laboratory Independent Research (ILIR) funding. J. V. F. and H. O. E. thank U. Ozgur for a critical reading of an early version of this manuscript. NR 30 TC 22 Z9 22 U1 0 U2 15 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD MAR PY 2010 VL 81 IS 11 AR 115318 DI 10.1103/PhysRevB.81.115318 PG 10 WC Physics, Condensed Matter SC Physics GA 577UF UT WOS:000276248800095 ER PT J AU Ignaccolo, M Latka, M Jernajczyk, W Grigolini, P West, BJ AF Ignaccolo, M. Latka, M. Jernajczyk, W. Grigolini, P. West, B. J. TI Dynamics of electroencephalogram entropy and pitfalls of scaling detection SO PHYSICAL REVIEW E LA English DT Article ID TEEN BIRTH PHENOMENON; FLUCTUATION ANALYSIS; TIME-SERIES; BEHAVIOR; EEG AB In recent studies a number of research groups have determined that human electroencephalograms (EEG) have scaling properties. In particular, a crossover between two regions with different scaling exponents has been reported. Herein we study the time evolution of diffusion entropy to elucidate the scaling of EEG time series. For a cohort of 20 awake healthy volunteers with closed eyes, we find that the diffusion entropy of EEG increments (obtained from EEG waveforms by differencing) exhibits three features: short-time growth, an alpha wave related oscillation whose amplitude gradually decays in time, and asymptotic saturation which is achieved after approximately 1 s. This analysis suggests a linear, stochastic Ornstein-Uhlenbeck Langevin equation with a quasiperiodic forcing (whose frequency and/or amplitude may vary in time) as the model for the underlying dynamics. This model captures the salient properties of EEG dynamics. In particular, both the experimental and simulated EEG time series exhibit short-time scaling which is broken by a strong periodic component, such as alpha waves. The saturation of EEG diffusion entropy precludes the existence of asymptotic scaling. We find that the crossover between two scaling regions seen in detrended fluctuation analysis (DFA) of EEG increments does not originate from the underlying dynamics but is merely an artifact of the algorithm. This artifact is rooted in the failure of the "trend plus signal" paradigm of DFA. C1 [Ignaccolo, M.; West, B. J.] Duke Univ, Dept Phys, Durham, NC 27709 USA. [Latka, M.] Wroclaw Univ Technol, Inst Biomed Engn, PL-50370 Wroclaw, Poland. [Jernajczyk, W.] Inst Psychiat & Neurol, Dept Clin Neurophysiol, Warsaw, Poland. [Grigolini, P.] Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA. [West, B. J.] USA, Res Off, Informat Sci Directorate, Res Triangle Pk, NC 27709 USA. RP Ignaccolo, M (reprint author), Duke Univ, Dept Phys, Durham, NC 27709 USA. FU Army Research Office FX M. I. and P. G. thank the Army Research Office for support of this research. The code of the programs used for the EEG analysis (DE and spectrogram) can be downloaded following this link [27]. The code used for the DFA analysis is the one available at PhysioNet website [8]. We thank Andrzej Latka for his comments on the manuscript. NR 26 TC 9 Z9 9 U1 2 U2 7 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1539-3755 J9 PHYS REV E JI Phys. Rev. E PD MAR PY 2010 VL 81 IS 3 AR 031909 DI 10.1103/PhysRevE.81.031909 PN 1 PG 9 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA 577CT UT WOS:000276199300092 PM 20365772 ER PT J AU Aronson, NE Wortmann, GW Byrne, WR Howard, RS Bernstein, WB Marovich, MA Polhemus, ME Yoon, IK Hummer, KA Gasser, RA Oster, CN Benson, PM AF Aronson, Naomi E. Wortmann, Glenn W. Byrne, William R. Howard, Robin S. Bernstein, Wendy B. Marovich, Mary A. Polhemus, Mark E. Yoon, In-Kyu Hummer, Kelly A. Gasser, Robert A., Jr. Oster, Charles N. Benson, Paul M. TI A Randomized Controlled Trial of Local Heat Therapy Versus Intravenous Sodium Stibogluconate for the Treatment of Cutaneous Leishmania major Infection SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID MACROPHAGES INVITRO; COST-EFFECTIVENESS; EFFICACY; THERMOTHERAPY; AFGHANISTAN; GLUCANTIME; PARASITES; KABUL AB Background: Cutaneous Leishmania major has affected many travelers including military personnel in Iraq and Afghanistan. Optimal treatment for this localized infection has not been defined, but interestingly the parasite is thermosensitive. Methodology/Principal Findings: Participants with parasitologically confirmed L. major infection were randomized to receive intravenous sodium stibogluconate (SSG) 20mg/kg/day for ten doses or localized ThermoMed (TM) device heat treatment (applied at 50 degrees C for 30 seconds) in one session. Those with facial lesions, infection with other species of Leishmania, or more than 20 lesions were excluded. Primary outcome was complete re-epithelialization or visual healing at two months without relapse over 12 months. Fifty-four/56 enrolled participants received intervention, 27 SSG and 27 TM. In an intent to treat analysis the per subject efficacy at two months with 12 months follow-up was 54% SSG and 48% TM (p = 0.78), and the per lesion efficacy was 59% SSG and 73% TM (p = 0.053). Reversible abdominal pain/pancreatitis, arthralgias, myalgias, headache, fatigue, mild cytopenias, and elevated transaminases were more commonly present in the SSG treated participants, whereas blistering, oozing, and erythema were more common in the TM arm. Conclusions/Significance: Skin lesions due to L. major treated with heat delivered by the ThermoMed device healed at a similar rate and with less associated systemic toxicity than lesions treated with intravenous SSG. C1 [Aronson, Naomi E.; Wortmann, Glenn W.; Bernstein, Wendy B.; Marovich, Mary A.; Polhemus, Mark E.; Gasser, Robert A., Jr.; Oster, Charles N.] Uniformed Serv Univ Hlth Sci, Div Infect Dis, Bethesda, MD 20814 USA. [Aronson, Naomi E.; Wortmann, Glenn W.; Byrne, William R.; Polhemus, Mark E.; Hummer, Kelly A.; Gasser, Robert A., Jr.; Oster, Charles N.; Benson, Paul M.] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. [Howard, Robin S.] Walter Reed Army Med Ctr, Dept Clin Invest, Washington, DC 20307 USA. [Bernstein, Wendy B.; Marovich, Mary A.] Walter Reed Army Inst Res, Dept Retroviral, Rockville, MD USA. [Yoon, In-Kyu] Walter Reed Army Inst Res, Dept Clin Trials, Silver Spring, MD USA. [Hummer, Kelly A.] Clin Res Management, Hinckley, OH USA. RP Aronson, NE (reprint author), Uniformed Serv Univ Hlth Sci, Div Infect Dis, Bethesda, MD 20814 USA. EM Naomi.aronson@us.army.mil FU Walter Reed Army Medical Center; North Atlantic Regional Medical Command; US Army Medical and Materiel Development Agency; US Army Medical Materiel and Development Agency FX This trial was supported by Walter Reed Army Medical Center, The North Atlantic Regional Medical Command, and the US Army Medical and Materiel Development Agency. The study sponsor (US Army Medical Materiel and Development Agency) reviewed the study protocol during development, provided the study drug (SSG) and trial monitoring, and approved this manuscript. NR 27 TC 35 Z9 35 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1935-2727 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD MAR PY 2010 VL 4 IS 3 AR e628 DI 10.1371/journal.pntd.0000628 PG 8 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 578RG UT WOS:000276312200026 PM 20231896 ER PT J AU Fried, JR Gibbons, RV Kalayanarooj, S Thomas, SJ Srikiatkhachorn, A Yoon, IK Jarman, RG Green, S Rothman, AL Cummings, DAT AF Fried, Jessica R. Gibbons, Robert V. Kalayanarooj, Siripen Thomas, Stephen J. Srikiatkhachorn, Anon Yoon, In-Kyu Jarman, Richard G. Green, Sharone Rothman, Alan L. Cummings, Derek A. T. TI Serotype-Specific Differences in the Risk of Dengue Hemorrhagic Fever: An Analysis of Data Collected in Bangkok, Thailand from 1994 to 2006 SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID DISEASE SEVERITY; VIRUS-INFECTION; SHOCK SYNDROME; HLA-B; MANIFESTATIONS; VIRULENCE; CORRELATE; OUTBREAK; CHILDREN; LESSONS AB Background: It is unclear whether dengue serotypes differ in their propensity to cause severe disease. We analyzed differences in serotype-specific disease severity in children presenting for medical attention in Bangkok, Thailand. Methodology/Principal Findings: Prospective studies were conducted from 1994 to 2006. Univariate and multivariate logistic and multinomial logistic regressions were used to determine if dengue hemorrhagic fever (DHF) and signs of severe clinical disease (pleural effusion, ascites, thrombocytopenia, hemoconcentration) were associated with serotype. Crude and adjusted odds ratios were calculated. There were 162 (36%) cases with DENV-1, 102 (23%) with DENV-2, 123 (27%) with DENV-3, and 64 (14%) with DENV-4. There was no significant difference in the rates of DHF by serotype: DENV-2 (43%), DENV-3 (39%), DENV-1 (34%), DENV-4 (31%). DENV-2 was significantly associated with increased odds of DHF grade I compared to DF (OR 2.9 95% CI 1.1, 8.0), when using DENV-1 as the reference. Though not statistically significant, DENV-2 had an increased odds of total DHF and DHF grades II, III, and IV. Secondary serologic response was significantly associated with DHF (OR 6.2) and increased when considering more severe grades of DHF. DENV-2 (9%) and -4 (3%) were significantly less often associated with primary disease than DENV-1 (28%) and -3 (33%). Restricting analysis to secondary cases, we found DENV-2 and DENV-3 to be twice as likely to result in DHF as DEN-4 (p = 0.05). Comparing study years, we found the rate of DHF to be significantly less in 1999, 2000, 2004, and 2005 than in 1994, the study year with the highest percentage of DHF cases, even when controlling for other variables. Conclusions/Significance: As in other studies, we find secondary disease to be strongly associated with DHF and with more severe grades of DHF. DENV-2 appears to be marginally associated with more severe dengue disease as evidenced by a significant association with DHF grade I when compared to DENV-1. In addition, we found non-significant trends with other grades of DHF. Restricting the analysis to secondary disease we found DENV-2 and -3 to be twice as likely to result in DHF as DEN-4. Differences in severity by study year may suggest that other factors besides serotype play a role in disease severity. C1 [Fried, Jessica R.] Mahidol Univ, Mahidol Oxford Trop Med Res Unit MORU, Fac Trop Med, Bangkok 10700, Thailand. [Gibbons, Robert V.; Thomas, Stephen J.; Yoon, In-Kyu; Jarman, Richard G.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. [Srikiatkhachorn, Anon; Green, Sharone; Rothman, Alan L.] Univ Massachusetts, Sch Med, Worcester, MA USA. [Cummings, Derek A. T.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. RP Fried, JR (reprint author), Mahidol Univ, Mahidol Oxford Trop Med Res Unit MORU, Fac Trop Med, Bangkok 10700, Thailand. EM jessica@tropmedres.ac FU NIH [P01 AI034533, U01-GM070708]; U.S. Army Medical Research and Materiel Command; Bill & Melinda Gates Foundation; Burroughs Wellcome Fund FX The studies were supported in part by NIH grant P01 AI034533 and the U.S. Army Medical Research and Materiel Command. DATC's work on this project was funded by grants from the NIH (U01-GM070708) and the Bill & Melinda Gates Foundation. DATC also holds a Career Award at the Scientific Interface from the Burroughs Wellcome Fund. No funders had a role in data analysis, preparation of the manuscript, or decision to publish. NR 37 TC 85 Z9 88 U1 3 U2 15 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1935-2727 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD MAR PY 2010 VL 4 IS 3 AR e617 DI 10.1371/journal.pntd.0000617 PG 6 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 578RG UT WOS:000276312200031 PM 20209155 ER PT J AU Mwamukonda, K Chen, Y Ravindranath, L Furusato, B Hu, Y Sterbis, J Osborn, D Rosner, I Sesterhenn, IA McLeod, DG Srivastava, S Petrovics, G AF Mwamukonda, K. Chen, Y. Ravindranath, L. Furusato, B. Hu, Y. Sterbis, J. Osborn, D. Rosner, I. Sesterhenn, I. A. McLeod, D. G. Srivastava, S. Petrovics, G. TI Quantitative expression of TMPRSS2 transcript in prostate tumor cells reflects TMPRSS2-ERG fusion status SO PROSTATE CANCER AND PROSTATIC DISEASES LA English DT Article DE TMPRSS2; quantitative expression; TMPRSS2-ERG fusion ID SERINE-PROTEASE TMPRSS2; CANCER; GENE; TRANSMEMBRANE; TISSUES AB TMPRSS2-ERG fusion is the most common oncogenic rearrangement in prostate cancer (CaP). Owing to this chromosomal rearrangement one TMPRSS2 allele loses its promoter, and one of the ETS-related gene (ERG) alleles gains that promoter leading to its overexpression in these tumor cells. Some studies suggest that TMPRSS2, an androgen-regulated type II transmembrane serine protease, may have an effect on CaP progression. We hypothesized that a difference in TMPRSS2 expression may be present in vivo between CaP cells with and without TMPRSS2-ERG fusion, or a compensatory mechanism for the allelic loss of TMPRSS2 may balance that expression difference. Therefore, TMPRSS2 mRNA expression was evaluated in microdissected CaP cells with and without TMPRSS2-ERG fusion in 132 CaP patients and analyzed for its correlation with other androgen receptor (AR)-regulated genes and clinicopathological features. In vivo TMPRSS2 expression correlated with that of other AR-regulated genes, including PSA/KLK3 and PMEPA1, offering potential as AR surrogates. A significantly reduced expression of TMPRSS2 was evident in malignant cells harboring TMPRSS2-ERG fusion, but not in CaP cells without TMPRSS2-ERG fusion, further defining these two genetically distinct types of CaP. Prostate Cancer and Prostatic Diseases (2010) 13, 47-51; doi:10.1038/pcan.2009.28; published online 14 July 2009 C1 [Chen, Y.; Ravindranath, L.; Furusato, B.; Hu, Y.; McLeod, D. G.; Srivastava, S.; Petrovics, G.] Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, Rockville, MD 20852 USA. [Mwamukonda, K.; Sterbis, J.; Osborn, D.; Rosner, I.; McLeod, D. G.] Walter Reed Army Med Ctr, Dept Surg, Urol Serv, Washington, DC 20307 USA. [Furusato, B.; Sesterhenn, I. A.] Armed Forces Inst Pathol, Dept Genitourinary Pathol, Washington, DC 20306 USA. [McLeod, D. G.; Srivastava, S.] Uniformed Serv Univ Hlth Sci, US Mil Canc Inst, Bethesda, MD 20814 USA. RP Petrovics, G (reprint author), Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, 1530 E Jefferson St, Rockville, MD 20852 USA. EM ssrivastava@cpdr.org; gpetrovics@cpdr.org OI Furusato, Bungo/0000-0003-4614-9882 FU National Institutes of Health [5R01 DK065977] FX This work was supported in part by grant 5R01 DK065977 for SS and GP from the National Institutes of Health. The views expressed in this paper are those of the authors and do not reflect the official policy of the Department of the Army, Department of Defense or the US Government. NR 15 TC 12 Z9 12 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1365-7852 J9 PROSTATE CANCER P D JI Prostate Cancer Prostatic Dis. PD MAR PY 2010 VL 13 IS 1 BP 47 EP 51 DI 10.1038/pcan.2009.28 PG 5 WC Oncology; Urology & Nephrology SC Oncology; Urology & Nephrology GA 553WM UT WOS:000274397500008 PM 19597533 ER PT J AU Capaldi, VF Wynn, GH AF Capaldi, Vincent F., II Wynn, Gary H. TI Post Stroke Depression: Treatments and Complications in a Young Adult SO PSYCHIATRIC QUARTERLY LA English DT Article DE Post stroke depression; Brainstem stroke; Migrainous vasospasm; TCA; SSRI; Methylphenidate; Aripiprazole; Suicidality ID POSTSTROKE DEPRESSION; DOUBLE-BLIND; VASCULAR DEPRESSION; PSEUDOBULBAR AFFECT; ARTERY-OCCLUSION; RECOVERY; PLACEBO; SERTRALINE; DISORDERS; METHYLPHENIDATE AB Post-stroke depression has been noted to be one of the most frequent complications of stroke with an estimated prevalence of as high as 80%. However, the incidence of stroke in the young is extremely low and evidence based therapy for this complication is quite limited. The case of a 28-year-old woman who experienced a basilar artery vasospasmic stroke resulting in anoxic brain injury to the midbrain and paramedian thalamus is presented, along with a literature review of psychiatric complications of this injury to include post-stroke depression (PSD). Therapeutic modalities such as TCAs, SSRIs, atypical antipsychotics and stimulant medications are also reviewed as these medications may aid in the treatment of such patients but may also contribute to psychiatric sequelae. C1 [Capaldi, Vincent F., II; Wynn, Gary H.] Walter Reed Army Med Ctr, Dept Psychiat, Washington, DC 20307 USA. [Capaldi, Vincent F., II; Wynn, Gary H.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. RP Capaldi, VF (reprint author), Walter Reed Army Med Ctr, Dept Psychiat, 6900 Georgia Ave, Washington, DC 20307 USA. EM vin@capaldi.org RI Wynn, Gary/B-3618-2011 NR 36 TC 1 Z9 2 U1 3 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0033-2720 J9 PSYCHIAT QUART JI Psychiatr. Q. PD MAR PY 2010 VL 81 IS 1 BP 73 EP 79 DI 10.1007/s11126-009-9120-8 PG 7 WC Psychiatry SC Psychiatry GA 552ZP UT WOS:000274334100006 PM 20033774 ER PT J AU Ritchie, G Harvey, DJ Stroeher, U Feldmann, F Feldmann, H Wahl-Jensen, V Royle, L Dwek, RA Rudd, PM AF Ritchie, Gayle Harvey, David J. Stroeher, Ute Feldmann, Friederike Feldmann, Heinz Wahl-Jensen, Victoria Royle, Louise Dwek, Raymond A. Rudd, Pauline M. TI Identification of N-glycans from Ebola virus glycoproteins by matrix-assisted laser desorption/ionisation time-of-flight and negative ion electrospray tandem mass spectrometry SO RAPID COMMUNICATIONS IN MASS SPECTROMETRY LA English DT Article ID MARBURG VIRUS; LINKED GLYCANS; HEMORRHAGIC-FEVER; DESORPTION IONIZATION; VIRION GLYCOPROTEINS; CELLULAR ENTRY; DC-SIGN; FRAGMENTATION; SGP; INFECTION AB The larger fragment of the transmembrane glycoprotein (GP1) and the soluble glycoprotein (sGP) of Ebola virus were expressed in human embryonic kidney cells and the secreted products were purified from the supernatant for carbohydrate analysis. The N-glycans were released with PNGase F from within sodium dodecyl sulphate/polyacrylamide gel electrophoresis (SDS-PAGE) gels. Identification of the glycans was made with normal-phase high-performance liquid chromatography (HPLC), matrix-assisted laser desorption/ionisation mass spectrometry, negative ion electrospray ionisation fragmentation mass spectrometry and exoglycosidase digestion. Most glycans were complex bi-, tri- and tetra-antennary compounds with reduced amounts of galactose. No bisected compounds were detected. Triantennary glycans were branched on the 6-antenna; fucose was attached to the core GlcNAc residue. Sialylated glycans were present on sGP but were largely absent from GP1, the larger fragment of the transmembrane glycoprotein. Consistent with this was the generally higher level of processing of carbohydrates found on sGP as evidenced by a higher percentage of galactose and lower levels of high-mannose glycans than were found on GP1. These results confirm and expand previous findings on partial characterisation of the Ebola virus transmembrane glycoprotein. They represent the first detailed data on carbohydrate structures of the Ebola virus sGP. Copyright (C) 2010 John Wiley & Sons, Ltd. C1 [Ritchie, Gayle; Harvey, David J.; Dwek, Raymond A.] Univ Oxford, Dept Biochem, Oxford Glycobiol Inst, Oxford OX1 3QU, England. [Stroeher, Ute; Feldmann, Friederike; Feldmann, Heinz; Wahl-Jensen, Victoria] Publ Hlth Agcy Canada, Special Pathogens Program, Natl Microbiol Lab, Winnipeg, MB R3E 3R2, Canada. [Stroeher, Ute; Feldmann, Friederike; Feldmann, Heinz] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB R3E 0W3, Canada. [Wahl-Jensen, Victoria] USA, Viral Therapeut Branch, Div Virol, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Royle, Louise; Rudd, Pauline M.] Univ Coll Dublin, Natl Inst Bioproc Res & Training, Conway Inst, Dublin 4, Ireland. RP Harvey, DJ (reprint author), Univ Oxford, Dept Biochem, Oxford Glycobiol Inst, S Parks Rd, Oxford OX1 3QU, England. EM david.harvey@bioch.ox.ac.uk RI Harvey, David/A-5579-2013 FU Public Health Agency of Canada FX We thank Brian Matthews for releasing the O-linked glycans with hydrazine. We also thank the Wellcome Trust and the Biotechnology and Biological Sciences Research Council for equipment grants to purchase the Q-Tof and TofSpec mass spectrometers, respectively. Studies on filoviruses at the National Microbiology Laboratory in Winnipeg were funded by the Public Health Agency of Canada. NR 61 TC 15 Z9 15 U1 1 U2 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0951-4198 EI 1097-0231 J9 RAPID COMMUN MASS SP JI Rapid Commun. Mass Spectrom. PD MAR PY 2010 VL 24 IS 5 BP 571 EP 585 DI 10.1002/rcm.4410 PG 15 WC Biochemical Research Methods; Chemistry, Analytical; Spectroscopy SC Biochemistry & Molecular Biology; Chemistry; Spectroscopy GA 573MT UT WOS:000275918700015 PM 20131323 ER PT J AU Chason, RJ Beall, SA Csokmay, JM Benne, MB Segars, JH AF Chason, Rebecca J. Beall, Stephanie A. Csokmay, John M. Benne, Melinda B. Segars, James H. TI Oocyte Maturation Failure: Incidence and Prognosis for Pregnancy at Assisted Reproduction SO REPRODUCTIVE SCIENCES LA English DT Meeting Abstract CT 57th Annual Meeting of the Society-for-Gynecologic-Investigation CY MAR 24-27, 2010 CL Orlando, FL SP Soc Gynecol Investigat C1 [Beall, Stephanie A.] Vanderbilt Univ, Nashville, TN USA. [Chason, Rebecca J.; Csokmay, John M.; Benne, Melinda B.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Chason, Rebecca J.; Csokmay, John M.; Segars, James H.] NICHHD, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1933-7191 J9 REPROD SCI JI Reprod. Sci. PD MAR PY 2010 VL 17 IS 3 SU S MA 989 BP 349A EP 349A PG 1 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 568XE UT WOS:000275558601461 ER PT J AU Risinger, JI Chandramouli, GVR Maxwell, GL AF Risinger, John I. Chandramouli, G. V. R. Maxwell, G. Larry TI MicroRNA Profiles of Serous and Endometrioid Endometrial Cancers. SO REPRODUCTIVE SCIENCES LA English DT Meeting Abstract CT 57th Annual Meeting of the Society-for-Gynecologic-Investigation CY MAR 24-27, 2010 CL Orlando, FL SP Soc Gynecol Investigat C1 [Risinger, John I.; Chandramouli, G. V. R.] Michigan State Univ, Coll Human Med, Dept Obstet Gynecol & Reprod Biol, Grand Rapids, MI USA. [Maxwell, G. Larry] Walter Reed Army Med Ctr, Div Gynecol Oncol, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1933-7191 J9 REPROD SCI JI Reprod. Sci. PD MAR PY 2010 VL 17 IS 3 SU S MA 1011 BP 356A EP 356A PG 1 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 568XE UT WOS:000275558601483 ER PT J AU Bellar, DM Kamimori, GH Glickman, EL AF Bellar, David M. Kamimori, Gary H. Glickman, Ellen L. TI Effects of Caffeine on Rating of Perceived Exertion and Pain During Anaerobic Testing SO RESEARCH QUARTERLY FOR EXERCISE AND SPORT LA English DT Meeting Abstract C1 [Bellar, David M.] Univ Louisiana Lafayette, Lafayette, LA USA. [Kamimori, Gary H.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Glickman, Ellen L.] Kent State Univ, Kent, OH USA. EM davidbellar@mac.com NR 0 TC 0 Z9 0 U1 2 U2 4 PU AMER ALLIANCE HEALTH PHYS EDUC REC & DANCE PI RESTON PA 1900 ASSOCIATION DRIVE, RESTON, VA 22091 USA SN 0270-1367 J9 RES Q EXERCISE SPORT JI Res. Q. Exerc. Sport PD MAR PY 2010 VL 81 IS 1 SU S BP 13 EP 14 PG 2 WC Hospitality, Leisure, Sport & Tourism; Psychology, Applied; Psychology; Sport Sciences SC Social Sciences - Other Topics; Psychology; Sport Sciences GA 567HK UT WOS:000275436700037 ER PT J AU Deng, WW Waits, CM Gomez, A AF Deng, Weiwei Waits, C. Mike Gomez, Alessandro TI Digital electrospray for controlled deposition SO REVIEW OF SCIENTIFIC INSTRUMENTS LA English DT Article DE damping; electrodeposition; ink jet printing; liquid phase deposition; microfabrication; polymers; spraying; suspensions; viscosity ID JET; CELLS AB Many novel functional structures are now fabricated by controlled deposition as a maskless, bottom-up fabrication technique. These applications require rapid and precise deposition of minute amounts of solutions/suspensions or their ultimate particle products in predefined patterns. The electrospray is a promising alternative to the commonly used inkjet printing because it can easily handle highly viscous liquid, avoid high shear rates, and has low risk of clogging. We demonstrate a proof-of-concept digital electrospray. This system consists of a 61-nozzle array microfabricated in silicon and a 61-element digital extractor fabricated using flexible polyimide substrates. "Digital" refers to the state of each electrospray source that can be tuned either on or off independently and responsively. We showed a resolution of 675 mu m and a response frequency up to 100 Hz. With similar design and industry standard fabrication procedures, it is feasible to scale up the system to O(1000) sources with spatial resolution better than 250 mu m and a O(kHz) response frequency. The latter is controlled by the viscous damping time. C1 [Deng, Weiwei; Gomez, Alessandro] Yale Univ, Dept Mech Engn, New Haven, CT 06520 USA. [Waits, C. Mike] USA, Res Lab, Adelphi, MD 20783 USA. RP Gomez, A (reprint author), Yale Univ, Dept Mech Engn, 9 Hillhouse Ave, New Haven, CT 06520 USA. EM alessandro.gomez@yale.edu RI Deng, Weiwei/C-2957-2011 FU U.S. Army [W911NF-05-2-0015] FX We thank Mr. Edward Jackson from the Department of Electrical Engineering at Yale University for his help in designing the control panel and Mr. Eric Dube from Tech-Etch for his help in designing the digital extractor. The support of the U.S. Army under Cooperative Agreement No. W911NF-05-2-0015 is gratefully acknowledged. NR 17 TC 5 Z9 5 U1 0 U2 18 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0034-6748 J9 REV SCI INSTRUM JI Rev. Sci. Instrum. PD MAR PY 2010 VL 81 IS 3 AR 035114 DI 10.1063/1.3340907 PG 6 WC Instruments & Instrumentation; Physics, Applied SC Instruments & Instrumentation; Physics GA 577GJ UT WOS:000276210200068 PM 20370220 ER PT J AU Holthoff, E Bender, J Pellegrino, P Fisher, A AF Holthoff, Ellen Bender, John Pellegrino, Paul Fisher, Almon TI Quantum Cascade Laser-Based Photoacoustic Spectroscopy for Trace Vapor Detection and Molecular Discrimination SO SENSORS LA English DT Article DE photoacoustic spectroscopy; sensor; quantum cascade laser; MEMS; chemometrics ID CHEMICAL SENSOR; MINIATURIZATION; INTEGRATION; CELL AB We report on the development of a microelectromechanical systems (MEMS)-scale photoacoustic sensor for the detection of trace gases. A mid-infrared quantum cascade laser (QCL) was used to determine detection limits for acetic acid, acetone, 1,4-dioxane, and vinyl acetate. The source was continuously tunable from 1015 cm(-1) to 1240 cm(-1), allowing for the collection of photoacoustic vibrational spectra for these gases. Exceptional agreement between the measured photoacoustic spectra and the infrared spectra for acetic acid, acetone, 1,4-dioxane, and vinyl acetate was observed. Partial least-squares (PLS) regression was used to develop an algorithm for classification of these compounds based solely on photoacoustic spectra. C1 [Holthoff, Ellen; Bender, John; Pellegrino, Paul] USA, Res Lab, RDRL SEE O, Adelphi, MD 20783 USA. [Fisher, Almon] Infoton Technol Ctr, Canandaigua, NY 14424 USA. RP Holthoff, E (reprint author), USA, Res Lab, RDRL SEE O, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ellen.holthoff@us.army.mil; john.s.bender@us.army.mil; ppellegr@arl.army.mil; almon.fisher@ITCMEMS.com NR 23 TC 41 Z9 41 U1 0 U2 11 PU MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI PI BASEL PA KANDERERSTRASSE 25, CH-4057 BASEL, SWITZERLAND SN 1424-8220 J9 SENSORS-BASEL JI Sensors PD MAR PY 2010 VL 10 IS 3 BP 1986 EP 2002 DI 10.3390/s100301986 PG 17 WC Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation SC Chemistry; Electrochemistry; Instruments & Instrumentation GA 589NY UT WOS:000277158300032 PM 22294910 ER PT J AU Wasif, N Faries, MB Saha, S Turner, RR Wiese, DD McCarter, MD Shen, P Stojadinovic, A Bilchik, AJ AF Wasif, Nabil Faries, Mark B. Saha, Sukamal Turner, Roderick R. Wiese, David D. McCarter, Martin D. Shen, Perry Stojadinovic, Alexander Bilchik, Anton J. TI Predictors of occult nodal metastasis in colon cancer: Results from a prospective multicenter trial SO SURGERY LA English DT Article ID REGIONAL LYMPH-NODES; COLORECTAL-CANCER; MICROMETASTASES; CARCINOMA; RECURRENCE; RISK AB Background. The relationship between primary colon cancer and occult nodal metastases (OMs) detected, by cytokeratin immunohistochemistry (CK-IHC) is unknown. We sought to investigate the correlation of clinicopathologic features of colon cancer with OMs and. to identify predictors of OM. Methods. Patients with colon cancer from 5 tertiary referral cancer centers enrolled in a prospective trial of staging had standard pathologic analysis performed on all resected lymph, nodes (using hematoxylin and eosin staining [H&E]). Nodes negative on H&E underwent CK-IHC to detect OMs, which were defined as micrometastases (N1mic) or isolated tumor cells (N0i+). Patients who were negative on both H&E and CK-IHC were defined (is node negative (NN), and those positive on H&E were node positive (NP). The relationships between tumor characteristics and OMs were analyzed using the Kruskal-Wallis and the Fisher exact. test. Results. OMs were identified in 23.4% (25/107) of patients. No significant differences were found, in demographics, tumor location, tumor size, and number of nodes examined between groups. Compared with the NN group, patients with OMs had more tumors that were T3/T4 (72% vs 57%; P < .001), had tumors of higher grade (28% vs 12%; P = .022), and had tumors with lymphovascular invasion (16% vs 3%; P <. 001). Conclusion. Adverse primary pathologic colon cancer characteristics correlate with OMs. In patients with negative nodes on H&E. and stage T3/T4 colon cancer, lymphovascular invasion, or high tumor grade, consideration should given to performing CK-IHC. the detection of OMs in this subset may influence decisions regarding adjuvant chemotherapy and risk stratification. (Surgery 2010;147:352-7.) C1 [Bilchik, Anton J.] Univ Calif Los Angeles, David Geffen Sch Med, Santa Monica, CA 90404 USA. [Wasif, Nabil; Faries, Mark B.; Turner, Roderick R.] St Johns Hlth Ctr, John Wayne Canc Inst, Santa Monica, CA USA. [Bilchik, Anton J.] Calif Oncol Res Inst, Santa Monica, CA USA. [Saha, Sukamal; Wiese, David D.] Michigan State Univ, McLaren Reg Med Ctr, Flint, MI USA. [McCarter, Martin D.] Univ Colorado, Dept Surg, Div GI Tumors & Endocrine Surg, Denver, CO 80202 USA. [McCarter, Martin D.] Univ Colorado, Hlth Sci Ctr, Denver, CO USA. [Shen, Perry] Wake Forest Univ, Med Ctr, Dept Surg Oncol, Winston Salem, NC USA. [Stojadinovic, Alexander] Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA. RP Bilchik, AJ (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, 2336 Santa Monica Blvd,Suite 206, Santa Monica, CA 90404 USA. EM abilchik@mednet.ucla.edu FU National Cancer Institute [2RO1CA090848-05A2]; William Randolph Hearst Foundation; Joyce E. and Ben B. Eisenberg Foundation; Davidow Charitable Food; Sequouia Foundation; Mrs. Ruth Weil; Rod Fasone Memorial Cancer Fund; Henry L. Guenther Foundation FX supported by Grant 2RO1CA090848-05A2 from the National Cancer Institute and by funding from the William Randolph Hearst Foundation (San Francisco, CA), The Joyce E. and Ben B. Eisenberg Foundation (Los Angeles, CA), Davidow Charitable Food (Los Angeles, CA), the Sequouia Foundation, Mrs. Ruth Weil (Los Angeles, CA), the Rod Fasone Memorial Cancer Fund (Los Angeles, CA), and the Henry L. Guenther Foundation (Los Angeles, CA). NR 23 TC 16 Z9 16 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0039-6060 J9 SURGERY JI Surgery PD MAR PY 2010 VL 147 IS 3 BP 352 EP 357 DI 10.1016/j.surg.2009.10.008 PG 6 WC Surgery SC Surgery GA 566DQ UT WOS:000275350700005 PM 20116081 ER PT J AU Kosaraju, A Barrigan, CR Poropatich, RK Casscells, SW AF Kosaraju, Akhila Barrigan, Cynthia R. Poropatich, Ronald K. Casscells, Samuel Ward TI Use of Mobile Phones as a Tool for United States Health Diplomacy Abroad SO TELEMEDICINE JOURNAL AND E-HEALTH LA English DT Article DE policy; telehealth; military medicine ID SHORT-MESSAGE SERVICE AB Rapidly emerging mobile communications platforms, such as mobile phones, in countries across Africa, Iraq, and Afghanistan offer new opportunities for direct public engagement in health systems, placing tools and timely information into the hands of those who need it most. Early results from pioneering work suggest real benefits of mobile devices in addressing access to care, monitoring and treating diseases, and providing continuous medical education and training. The Military Health System, a $43-billion global healthcare system within the U.S. Department of Defense, in partnership with other U.S. government agencies and nongovernmental organizations and the international health sector, can make valuable contributions to creating a sustainable global m-health infrastructure. C1 [Kosaraju, Akhila] Hlth Affairs, Dept Def, Washington, DC 20301 USA. [Barrigan, Cynthia R.; Poropatich, Ronald K.] USA, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. [Poropatich, Ronald K.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Casscells, Samuel Ward] Univ Texas Austin, Hlth Sci Ctr, Austin, TX USA. RP Kosaraju, A (reprint author), Hlth Affairs, Dept Def, 1200 Def Pentagon, Washington, DC 20301 USA. EM akhila.kosaraju@ha.osd.mil NR 22 TC 5 Z9 5 U1 1 U2 16 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-5627 J9 TELEMED J E-HEALTH JI Telemed. J. e-Health PD MAR PY 2010 VL 16 IS 2 BP 219 EP 223 DI 10.1089/tmj.2009.0095 PG 5 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 571MS UT WOS:000275756500012 PM 20156128 ER PT J AU O'Donnell, JC McDonough, JH Shih, TM AF O'Donnell, John C. McDonough, John H. Shih, Tsung-Ming TI Changes in extracellular striatal acetylcholine and brain seizure activity following acute exposure to nerve agents in freely moving guinea pigs SO TOXICOLOGY MECHANISMS AND METHODS LA English DT Article DE Acetylcholine; acetylcholinesterase; choline; guinea pig; in vivo microdialysis; nerve agents; organophosphorus compounds; sarin; seizure activity; soman; VR; VX ID SOMAN-INDUCED SEIZURES; CARBOXYLESTERASE INHIBITION; ATROPINE SULFATE; ORGANOPHOSPHORUS; TOXICITY; EFFICACY; BARRIER; MICRODIALYSIS; MECHANISMS; RATS AB Organophosphorus nerve agents irreversibly inhibit acetylcholinesterase (AChE) in the peripheral and central nervous systems, causing an increase in the concentration of acetylcholine (ACh) in the synapse or neuromuscular junction and subsequent adverse effects. In this study, in vivo microdialysis was utilized to collect samples from the striatum for monitoring changes in extracellular ACh levels along with cortical electroencephalographic (EEG) recordings for identifying seizure activity after acute subcutaneous (s.c.) exposure to 1.0 x LD(50) of the nerve agents sarin, soman, or one of two V-type agents (VX, or a Russian V-agent, designated VR) in unanesthetized freely moving guinea pigs. Based on EEG recordings, these animals were subsequently divided into groups that developed seizures (S) and those that did not develop seizures (NS). Maximum ACh levels in the striatum were observed at 60-70 min for sarin and soman S groups and 105 min for VX and VR S groups. In all NS groups the greatest increase in extracellular ACh occurred within 30 min after exposure, although in the sarin NS group a few sporadic increases of ACh from control occurred. Animals that developed seizures, regardless of the nerve agent, had significantly higher extracellular striatal ACh levels compared to the controls or those animals that did not develop seizures, yet both S and NS groups displayed similar levels of blood AChE inhibition. Regardless of the agent, all animals in the non-seizure groups survived 24 h, while lethality (25-42%) was observed only in animals that experienced seizure activity. C1 [O'Donnell, John C.; McDonough, John H.; Shih, Tsung-Ming] USA, Med Res Inst Chem Def, Div Res, Pharmacol Branch, Aberdeen Proving Ground, MD 21010 USA. RP Shih, TM (reprint author), USA, Med Res Inst Chem Def, Div Res, Pharmacol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM tsungming.a.shih@us.army.mil FU Defense Threat Reduction Agency-Joint Service and Technology Office, Medical Science and Technology Division FX The authors express their appreciation for the excellent technical assistance of Steven Raiker, Kathleen McAvoy, Cindy Acon-Chen, Jeffrey Koenig, Teresa Ferrara, and Dr Bruce J. Jung. This research was supported by the Defense Threat Reduction Agency-Joint Service and Technology Office, Medical Science and Technology Division. NR 38 TC 3 Z9 4 U1 0 U2 3 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1537-6524 J9 TOXICOL MECH METHOD JI Toxicol. Mech. Methods PD MAR PY 2010 VL 20 IS 3 BP 143 EP 152 DI 10.3109/15376511003657439 PG 10 WC Toxicology SC Toxicology GA 560FD UT WOS:000274886500007 PM 20163292 ER PT J AU Diniz, PPVP Beall, MJ Omark, K Chandrashekar, R Daniluk, DA Cyr, KE Koterski, JF Robbins, RG Lalo, PG Hegarty, BC Breitschwerdt, EB AF Diniz, Pedro Paulo V. P. Beall, Melissa J. Omark, Karina Chandrashekar, Ramaswamy Daniluk, Daryn A. Cyr, Katie E. Koterski, James F. Robbins, Richard G. Lalo, Pamela G. Hegarty, Barbara C. Breitschwerdt, Edward B. TI High Prevalence of Tick-Borne Pathogens in Dogs from an Indian Reservation in Northeastern Arizona SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Anaplasma; Babesia; Bartonella; Ehrlichia; Rickettsia; Sentinel ID SPOTTED-FEVER GROUP; CONSERVED IMMUNODOMINANT REGION; RHIPICEPHALUS-SANGUINEUS TICKS; EHRLICHIA-CANIS INFECTION; RICKETTSIA-RICKETTSII; BORRELIA-BURGDORFERI; UNITED-STATES; ANAPLASMA-PLATYS; EASTERN ARIZONA; VECTOR AB We evaluated the serological and molecular prevalence of selected organisms in 145 dogs during late spring (May/June) of 2005 and in 88 dogs during winter (February) of 2007 from the Hopi Indian reservation. Additionally, in 2005, 442 ticks attached to dogs were collected and identified as Rhipicephalus sanguineus. Infection with or exposure to at least one organism was detected in 69% and 66% of the dogs in May/June 2005 and February 2007, respectively. Exposure to spotted fever group (SFG) rickettsiae was detected in 66.4% (2005) and 53.4% (2007) of dogs, but rickettsial DNA was not detected using polymerase chain reaction. Active Ehrlichia canis infection (by polymerase chain reaction) was identified in 36.6% (2005) and 36.3% (2007) of the dogs. E. canis infection was associated with SFG rickettsiae seroreactivity (p < 0.001). Anaplasma platys DNA was detected in 8.3% (2005) and 4.5% (2007) of the dogs. Babesia canis and Bartonella vinsonii berkhoffii seroprevalences were 6.7% and 1% in 2005, whereas in 2007 prevalences were 0% and 1.1%, respectively. No Bartonella spp., Ehrlichia chaffeensis, or Ehrlichia ewingii DNA was detected. Dogs on this Hopi Indian reservation were most frequently infected with E. canis or A. platys; however, more than half of the dogs were exposed to a SFG-Rickettsia species. C1 [Diniz, Pedro Paulo V. P.; Hegarty, Barbara C.; Breitschwerdt, Edward B.] N Carolina State Univ, Coll Vet Med, Intracellular Pathogens Res Lab, Ctr Comparat Med & Translat Res, Raleigh, NC 27606 USA. [Beall, Melissa J.; Chandrashekar, Ramaswamy; Daniluk, Daryn A.; Cyr, Katie E.] IDEXX Labs, Westbrook, ME USA. [Omark, Karina] Yarmouth Vet Ctr, Yarmouth, ME USA. [Koterski, James F.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Robbins, Richard G.] Walter Reed Army Med Ctr, DPMIAC, AFPMB, Washington, DC 20307 USA. [Lalo, Pamela G.] Hopi Vet Serv, Polacca, AZ USA. RP Breitschwerdt, EB (reprint author), N Carolina State Univ, Coll Vet Med, Intracellular Pathogens Res Lab, Ctr Comparat Med & Translat Res, 4700 Hillsborough St,Res Bldg,Room 454, Raleigh, NC 27606 USA. EM ed_breitschwerdt@ncsu.edu RI Diniz, Pedro Paulo/B-2794-2013 FU IDEXX(R) Laboratories FX Dr. Pedro Diniz's stipend was supported by IDEXX (R) Laboratories as part of this study. NR 48 TC 19 Z9 19 U1 1 U2 7 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD MAR PY 2010 VL 10 IS 2 BP 117 EP 123 DI 10.1089/vbz.2008.0184 PG 7 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 575PS UT WOS:000276080100003 PM 19469667 ER PT J AU O'Guinn, ML Klein, TA Lee, JS Richards, AL Kim, HC Ha, SJ Shim, SH Baek, LJ Song, KJ Chong, ST Turell, MJ Burkett, DA Schuster, A Lee, IY Yi, SH Sames, WJ Song, JW AF O'Guinn, Monica L. Klein, Terry A. Lee, John S. Richards, Allen L. Kim, Heung-Chul Ha, Si Jung Shim, So Hee Baek, Luck Ju Song, Ki-Joon Chong, Sung-Tae Turell, Michael J. Burkett, Douglas A. Schuster, Anthony Lee, In-Yong Yi, Suk-Hee Sames, William J. Song, Jin-Won TI Serological Surveillance of Scrub Typhus, Murine Typhus, and Leptospirosis in Small Mammals Captured at Firing Points 10 and 60, Gyeonggi Province, Republic of Korea, 2001-2005 SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Apodemus; Crocidura; insectivores; leptospirosis; Micromys; Microtus; murine typhus; Myodes; Orientia; Rattus; Rickettsia; rodents; scrub typhus; Tscherskia ID POLYMERASE-CHAIN-REACTION; SPOTTED-FEVER GROUP; RICKETTSIA-TSUTSUGAMUSHI; CLINICAL-DIAGNOSIS; RAPID DIAGNOSIS; INFECTION; DISEASE; RODENTS; THAILAND; HUMANS AB Soldiers from the Republic of Korea and the United States conducting peacetime military operations at various training sites and multiple range complexes located near the demilitarized zone separating North and South Korea are exposed to rodents and their potentially disease-carrying ectoparasites. These diseases include scrub typhus, murine typhus, and leptospirosis. Many of the training sites are rural or semi-rural, surrounded or co-located with various forms of agriculture, and are infested with rodents and insectivores (as well as their ectoparasites), which are commonly found in association with unmanaged tall grasses, scrub, and crawling vegetation habitats. For 5 years, rodents and insectivores were collected seasonally (spring, summer, fall, and winter) at firing points 10 and 60 near the demilitarized zone and serologically tested for the presence of scrub typhus, murine typhus, and leptospirosis antibodies. Of the nine species of small mammals collected, Apodemus agrarius, the common striped field mouse and known reservoir of scrub typhus, was the most frequently collected (90.6%). Only four of the nine species captured, A. agrarius (60.9%), Micromys minutus (100%), Mus musculus (55.6%), and Rattus norvegicus (46.7%), were positive for scrub typhus. Of all the small mammals captured, only A. agrarius was positive for murine typhus (0.3%) and leptospirosis (1.3%). Seasonal and annual prevalence rates based on weight and sex are presented. C1 [Ha, Si Jung; Shim, So Hee; Baek, Luck Ju; Song, Ki-Joon; Song, Jin-Won] Korea Univ, Dept Microbiol, Coll Med, Inst Viral Dis, Seoul 136705, South Korea. [Ha, Si Jung; Shim, So Hee; Baek, Luck Ju; Song, Ki-Joon; Song, Jin-Won] Korea Univ, Dept Microbiol, Coll Med, Bank Pathogen Viruses, Seoul 136705, South Korea. [O'Guinn, Monica L.; Lee, John S.; Turell, Michael J.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Klein, Terry A.; Yi, Suk-Hee; Sames, William J.] Force Hlth Protect 18th Med Command, Unit 15281, APO, AP 96205 USA. [Richards, Allen L.] USN, Med Res Ctr, Viral & Rickettsial Dis Dept, Silver Spring, MD USA. [Kim, Heung-Chul; Chong, Sung-Tae] 18th Med Command, Unit 15247, APO, AP 96205 USA. [Burkett, Douglas A.] AF Inst Operat Hlth, Human Syst Wing 311, Unit 5213, Kadena AFB, Okinawa, Japan. [Schuster, Anthony] Ctr Hlth Promot & Prevent Med S, Atlanta, GA USA. [Lee, In-Yong] Yonsei Univ, Coll Med, Dept Environm Med Biol, Seoul, South Korea. RP Song, JW (reprint author), Korea Univ, Dept Microbiol, Coll Med, Inst Viral Dis, 126-1,5Ka Anam Dong, Seoul 136705, South Korea. EM jwsong@korea.ac.kr RI Valle, Ruben/A-7512-2013 FU U.S. Department of Defense Global Emerging Infections Surveillance and Response System, Silver Spring, MD; Armed Forces Medical Intelligence Center, Fort Detrick, MD FX Funding for portions of this work was provided by the U.S. Department of Defense Global Emerging Infections Surveillance and Response System, Silver Spring, MD, and the Armed Forces Medical Intelligence Center, Fort Detrick, MD. NR 71 TC 11 Z9 11 U1 1 U2 3 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD MAR PY 2010 VL 10 IS 2 BP 125 EP 133 DI 10.1089/vbz.2008.0123 PG 9 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 575PS UT WOS:000276080100004 PM 19402761 ER PT J AU Stuempfle, KJ Nindl, BC Kamimori, GH AF Stuempfle, Kristin J. Nindl, Bradley C. Kamimori, Gary H. TI Stress Hormone Responses to an Ultraendurance Race in the Cold SO WILDERNESS & ENVIRONMENTAL MEDICINE LA English DT Article DE ultraendurance race; cold; epinephrine; norepinephrine; ACTH; cortisol ID PROLONGED PHYSICAL-EXERCISE; PLASMA-CORTISOL; NOREPINEPHRINE RESPONSES; PHYSIOLOGICAL-RESPONSES; METABOLIC RESPONSES; EXHAUSTIVE EXERCISE; BIOCHEMICAL-CHANGES; WATER; EXPOSURE; GENDER AB Objective-Physical stress (exercise and/or environmental) activates the sympathetic-adrenal-medullary (SAM) and hypothalamic-pituitary-adrenocortical (HPA) axes. The combination of ultraendurance exercise in the cold presents a unique summated stress to the body. The purpose of this study was to assess the stress hormone response in runners, cyclists, and skiers participating in a 161-km ultraendurance race on a snow-packed course in the Alaskan wilderness. Methods-Forty-four athletes (20 runners, 17 cyclists, 7 skiers) competed on the same course of snow-machine trails and ice roads with each athlete carrying 7 kg of mandatory equipment. Prerace weight and blood samples were collected 2 days prior to the race start. Postrace measurements were made within 15 minutes of race finish. Hematocrit was measured, and blood samples were analyzed for levels of norepinephrine, epinephrine, adrenocorticotropic hormone, and cortisol. Results-Runners lost significant weight (-1.74 kg +/- 1.29) prerace to postrace. Hematocrit was maintained, and plasma volume increased minimally. Norepinephrine increased significantly prerace (279.9 pg/mL +/- 356.9) to postrace (691.7 pg/mL +/- 422.6) with no difference among divisions. Epinephrine did not change significantly during the race. Adrenocorticotropic hormone (2.40 pg/mL +/- 2.40 to 19.04 pg/mL +/- 45.38) increased significantly with no difference among divisions. Cortisol increased significantly prerace (12.03 mu g/dL +/- 5.66) to postrace (26.69 mu g/dL +/- 5.77), and postrace cortisol was significantly higher in runners vs skiers. Conclusions-These data suggest activation of both the SAM and HPA axes from an ultraendurance race in the cold and reveal the degree of stress hormone responses to this exhausting bout of exercise. C1 [Stuempfle, Kristin J.] Gettysburg Coll, Dept Hlth Sci, Gettysburg, PA 17325 USA. [Nindl, Bradley C.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Kamimori, Gary H.] Walter Reed Army Inst Res, Washington, DC 20307 USA. RP Stuempfle, KJ (reprint author), Gettysburg Coll, Dept Hlth Sci, Campus Box 432,300 N Washington St, Gettysburg, PA 17325 USA. NR 39 TC 6 Z9 8 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1080-6032 EI 1545-1534 J9 WILD ENVIRON MED JI Wildern. Environ. Med. PD SPR PY 2010 VL 21 IS 1 BP 22 EP 27 DI 10.1016/j.wem.2009.12.020 PG 6 WC Public, Environmental & Occupational Health; Sport Sciences SC Public, Environmental & Occupational Health; Sport Sciences GA 632PS UT WOS:000280437300005 PM 20591350 ER PT J AU Zhu, W Ku, D Zheng, JP Liang, Z Wang, B Zhang, C Walsh, S Au, G Plichta, EJ AF Zhu, W. Ku, D. Zheng, J. P. Liang, Z. Wang, B. Zhang, C. Walsh, S. Au, G. Plichta, E. J. TI Buckypaper-based catalytic electrodes for improving platinum utilization and PEMFC's performance SO ELECTROCHIMICA ACTA LA English DT Article DE PEMFC; Carbon nanotube; Buckypaper; Electrocatalyst; Pt utilization ID MEMBRANE FUEL-CELLS; CARBON NANOTUBES; SUPPORT MATERIAL; NANOPARTICLES; REDUCTION; OXYGEN; ELECTROCATALYSTS; DEPOSITION; CATHODES; LAYER AB Platinum (Pt) catalytic electrode was developed by using carbon nanotube films (buckypaper) as supporting medium and electrodeposition method to deposit Pt catalyst. Buckypapers are free-standing thin films consisting of single-walled carbon nanotubes (SWNTs), multi-walled carbon nanotubes (MWNTs) and/or carbon nanofibers (CNFs) held together by van der Waals forces without any chemical binders. Special mixed buckypapers was developed by layered microstructures with a dense and high-conducting SWNT networks at the surface, as well as large porous structures of CNF networks as back supports. This unique microstructure can lead to improve Pt catalyst accessibility and mass exchange properties. Pt particles of about 6 nm were uniformly deposited in porous buckypapers. A promising electrochemical surface area of similar to 40 m(2)/g was obtained from these electrodes. A Pt utilization as low as 0.28 g(pt)/kW was achieved for the cathode electrode at 80 degrees C. Pt utilization efficiency can be further improved by optimization of the electrodeposition condition in order to reduce the Pt particle size. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Zhu, W.; Zheng, J. P.] Florida State Univ, Coll Engn, Dept Elect & Comp Engn, Florida A&M Univ, Tallahassee, FL 32310 USA. [Zhu, W.; Ku, D.; Liang, Z.; Wang, B.; Zhang, C.] Florida State Univ, Coll Engn, Dept Ind Engn, Florida A&M Univ, Tallahassee, FL 32310 USA. [Zheng, J. P.] Florida State Univ, CAPS, Tallahassee, FL 32310 USA. [Liang, Z.; Wang, B.; Zhang, C.] Florida State Univ, HPMI, Tallahassee, FL 32310 USA. [Walsh, S.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Au, G.; Plichta, E. J.] USA, CERDEC, Ft Monmouth, NJ 07703 USA. RP Zheng, JP (reprint author), Florida State Univ, Coll Engn, Dept Elect & Comp Engn, Florida A&M Univ, 2525 Pottsdamer St, Tallahassee, FL 32310 USA. EM zheng@eng.fsu.edu; liang@eng.fsu.edu RI Zhu, Wei/B-4159-2010 FU AFRL NOLES program; Army CERDEC FX This research is partially supported by the AFRL NOLES program and Army CERDEC. NR 26 TC 25 Z9 28 U1 3 U2 30 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0013-4686 J9 ELECTROCHIM ACTA JI Electrochim. Acta PD FEB 28 PY 2010 VL 55 IS 7 BP 2555 EP 2560 DI 10.1016/j.electacta.2009.12.026 PG 6 WC Electrochemistry SC Electrochemistry GA 568RL UT WOS:000275540100054 ER PT J AU Slack, WT Sumners, JA Rooney, AP Taylor, CM AF Slack, William T. Sumners, Jason A. Rooney, Alejandro P. Taylor, Christopher M. TI Conservation Genetics of the Threatened Bayou Darter (Percidae: Etheostoma rubrum) in the Bayou Pierre System of Southwestern Mississippi SO COPEIA LA English DT Article ID POPULATION-STRUCTURE; INTEGRATED SOFTWARE; DNA VARIATION; MITOCHONDRIAL; TELEOSTEI; PHYLOGEOGRAPHY; FISHES; RIVER AB The Bayou Darter, Etheostoma rubrum, Is endemic to the Bayou Pierre system of southwestern Mississippi where it occupies swift, shallow riffles with coarse, firm substrata. The Bayou Pierre system has experienced extensive erosion in response to rapid headcutting leading to loss of riffle habitat and degradation of riverine conditions. Due to its high degree of habitat specificity along with ongoing habitat fragmentation and potentially reduced gene flow between Isolated populations, the Bayou Darter is vulnerable to severe population declines and possible extinction. Our objectives were to quantify levels of genetic diversity in the mitochondrial control region and Infer population structure across the range of the species. Sequencing of 106 sampled Individuals revealed only three mtDNA haplotypes with one variable site. Haplotype diversity and nucleotide diversity were low (h <= 0.11 and pi < 0.001), and there was no structure revealed among the four sampled populations. The low genetic diversity in E. rubrum may best be explained by a small range size and recent genetic bottleneck. C1 [Slack, William T.] Res & Collect Program, Museum Nat Sci, Mississippi Dept Wildlife Fisheries & Pk, Jackson, MS 39202 USA. [Sumners, Jason A.] Texas A&M Univ, Dept Wildlife & Fisheries Sci, College Stn, TX 77843 USA. [Rooney, Alejandro P.] Mississippi State Univ, Dept Biol Sci, Mississippi State, MS 39762 USA. [Taylor, Christopher M.] Texas Tech Univ, Dept Nat Resources Management, Lubbock, TX 79409 USA. RP Slack, WT (reprint author), USA, Waterways Expt Stn, Engn Res & Dev Ctr, EE-A,3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM todd.slack@usace.army.mil; jason.sumners@mdc.mo.gov; alejandro.rooney@ars.usda.gov; cm.taylor@ttu.edu NR 38 TC 0 Z9 0 U1 1 U2 8 PU AMER SOC ICHTHYOLOGISTS HERPETOLOGISTS PI CHARLESTON PA UNIV CHARLESTON, GRICE MARINE LABORATORY, 205 FORT JOHNSON RD, CHARLESTON, SC 29412 USA SN 0045-8511 J9 COPEIA JI Copeia PD FEB 26 PY 2010 IS 1 BP 176 EP 180 DI 10.1643/CG-09-055 PG 5 WC Zoology SC Zoology GA 564BI UT WOS:000275185500020 ER PT J AU Chen, L Bromberg, L Lee, JA Zhang, H Schreuder-Gibson, H Gibson, P Walker, J Hammond, PT Hatton, TA Rutledge, GC AF Chen, Liang Bromberg, Lev Lee, Jung Ah Zhang, Huan Schreuder-Gibson, Heidi Gibson, Phillip Walker, John Hammond, Paula T. Hatton, T. Alan Rutledge, Gregory C. TI Multifunctional Electrospun Fabrics via Layer-by-Layer Electrostatic Assembly for Chemical and Biological Protection SO CHEMISTRY OF MATERIALS LA English DT Article ID P-NITROPHENYL ACETATE; HYDROXAMIC ACIDS; ISOPROPYL METHYLPHOSPHONOFLUORIDATE; ENVIRONMENTAL APPLICATIONS; TRANSPORT-PROPERTIES; POLYMER NANOFIBERS; WARFARE AGENTS; FIBERS; MEMBRANES; HYDROLYSIS AB Breathable chemical and biological detoxifying protective fabrics are obtained via functionalization of electrospun fiber mats using a layer-by-layer electrostatic assembly technique. The chemically reactive polyanion, poly(N-hydroxyacrylamide) or poly(hydroxamic acid) (PHA), and bactericidal polycation, poly(N-vinylguanidine) (PVG), were synthesized and assembled electrostatically to generate multifunctional coatings on prefabricated polyacrylonitrile (PAN) fiber mats. Reactivity of PHA in the hydrolysis of diisopropyl fluorophosphate (DFP), a close analog of the chemical warfare agent sarin, was demonstrated. The DFP degradation rate with PHA is comparable to that with compounds such as isonicotinhydroxamic acid methiodide, an efficient catalyst of organophosphate ester hydrolysis. Protective fabrics functionalized with PVG/PHA layers are able to degrade DFP mists, with DFP hydrolysis rates 60-fold higher than those with unmodified fabrics under identical conditions. Fabrics modified with PVG/PHA layers are bactericidal against E. coli and S. epidermidis. Breathability of functionalized fiber mats as protective fabrics was evaluated versus standard reference fabrics. C1 [Chen, Liang; Bromberg, Lev; Lee, Jung Ah; Zhang, Huan; Hammond, Paula T.; Hatton, T. Alan; Rutledge, Gregory C.] MIT, Dept Chem Engn, Cambridge, MA 02139 USA. [Schreuder-Gibson, Heidi; Gibson, Phillip; Walker, John] USA, Res Dev & Engn Command, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Hatton, TA (reprint author), MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA. EM tahatton@mit.edu; rutledge@mit.edu RI Gibson, Phillip/D-2398-2010 OI Gibson, Phillip/0000-0002-6172-4438 FU Department of the Army, U.S. Army Research Office [W911NF-07-1-0139]; DuPont-MIT Alliance FX This work was sponsored in part by the Department of the Army, U.S. Army Research Office, under Grant W911NF-07-1-0139. Any opinions, findings, conclusions and recommendations expressed in this article are those of the authors and do not necessarily reflect the views of the U.S. Army Research Office. Partial support wits also provided by the DuPont-MIT Alliance. NR 66 TC 38 Z9 39 U1 6 U2 63 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0897-4756 J9 CHEM MATER JI Chem. Mat. PD FEB 23 PY 2010 VL 22 IS 4 BP 1429 EP 1436 DI 10.1021/cm902834a PG 8 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 555RI UT WOS:000274531300022 ER PT J AU Crum-Cianflone, NF Hullsiek, KH Marconi, VC Ganesan, A Weintrob, A Barthel, RV Agan, BK AF Crum-Cianflone, Nancy F. Hullsiek, Katherine Huppler Marconi, Vincent C. Ganesan, Anuradha Weintrob, Amy Barthel, Robert V. Agan, Brian K. CA Infect Dis Clinical Res Program TI Anal cancers among HIV-infected persons: HAART is not slowing rising incidence SO AIDS LA English DT Article DE anal cancer; antiretroviral therapy; epidemiology; HAART; HIV; incidence rates ID ACTIVE ANTIRETROVIRAL THERAPY; SQUAMOUS INTRAEPITHELIAL LESIONS; HUMAN-IMMUNODEFICIENCY-VIRUS; HUMAN-PAPILLOMAVIRUS INFECTION; UNITED-STATES; POSITIVE MEN; RISK-FACTOR; ERA; NEOPLASIA; TRENDS AB Objective: To evaluate the incidence rates of anal cancer over the HIV epidemic and assess the impact of HAART use on anal cancer events. Methods: We evaluated the incidence of and factors associated with anal cancer using longitudinal data from the prospective U. S. Military Natural History Study (19852008). Poisson regression and Cox proportional hazard models were utilized. Results: Among 4506 HIV-infected men with 37 806 person-years of follow-up, anal cancer rates (per 100 000 person-years) increased five-fold, from 11 in the pre-HAART to 55 in the HAART era (P = 0.02). Rates continued to increase, reaching 128 in 2006-2008. Persons with HIV infection for more than 15 years had a 12-fold higher rate than those with less than 5 years (348 vs. 28, P < 0.01). At cancer diagnosis (n - 19), median age was 42 years, median CD4 cell count was 432 cells/mu l, 74% had a CD4 nadir cell count less than 200 cells/mu l, 42% had a prior AIDS event, and 74% had received HAART. From separate models, prior AIDS event (hazard ratio 3.88, P = 0.01) and lower CD4 nadir (hazard ratio 0.85 per 50 cell, P = 0.03) were associated with anal cancer, with a trend for a history of gonorrhea (hazard ratio 2.43, P = 0.07). Duration of HAART use was not associated with a reduced risk of anal cancer (hazard ratio 0.94, P = 0.42). Conclusion: Incidence rates of anal cancer have progressively increased during the HIV epidemic. Persons with a longer duration of HIV infection have a substantially higher rate of anal cancer. As HIV-infected persons are experiencing longer life expectancies and HAART does not appear protective of anal cancer, studies on preventive strategies are needed. (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins C1 [Crum-Cianflone, Nancy F.] Naval Med Ctr San Diego, Infect Dis Clin, Clin Invest Dept KCA, San Diego, CA 92134 USA. [Crum-Cianflone, Nancy F.; Marconi, Vincent C.; Ganesan, Anuradha; Weintrob, Amy; Barthel, Robert V.; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Hullsiek, Katherine Huppler] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Marconi, Vincent C.] San Antonio Mil Med Ctr, Infect Dis Clin, San Antonio, TX USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Infect Dis Clin, Bethesda, MD USA. [Weintrob, Amy] Walter Reed Army Med Ctr, Infect Dis Clin, Washington, DC 20307 USA. [Barthel, Robert V.] Naval Med Ctr Portsmouth, Infect Dis Clin, Portsmouth, VA USA. RP Crum-Cianflone, NF (reprint author), Naval Med Ctr San Diego, Infect Dis Clin, Clin Invest Dept KCA, 34800 Bob Wilson Dr,Ste 5, San Diego, CA 92134 USA. EM nancy.crum@med.navy.mil RI Marconi, Vincent/N-3210-2014; OI Marconi, Vincent/0000-0001-8409-4689; Agan, Brian/0000-0002-5114-1669 FU IDCRP [G187YS-RV168D]; National Institute of Allergy and Infectious Diseases; National Institutes of Health (NIH) [Y1-AI-5072] FX Support for this work (IDCRP # G187YS-RV168D) was provided by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. The content of this publication is the sole responsibility of the authors and does not necessarily reflect the views or policies of the NIH or the Department of Health and Human Services, the DoD or the Departments of the Army, Navy, or Air Force. Mention of trade names, commercial products, or organizations does not imply endorsement by the U. S. Government. This work is original and has not been published elsewhere. NR 32 TC 92 Z9 93 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 J9 AIDS JI Aids PD FEB 20 PY 2010 VL 24 IS 4 BP 535 EP 543 DI 10.1097/QAD.0b013e328331f6e2 PG 9 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 563QK UT WOS:000275148000006 PM 19926961 ER PT J AU Landrum, ML Hullsiek, KH Ganesan, A Weintrob, AC Crum-Cianflone, NF Barthel, RV O'Connell, RJ Fieberg, A Chun, HM Marconi, VC Dolan, MJ Agan, BK AF Landrum, Michael L. Hullsiek, Katherine Huppler Ganesan, Anuradha Weintrob, Amy C. Crum-Cianflone, Nancy F. Barthel, R. Vincent O'Connell, Robert J. Fieberg, Ann Chun, Helen M. Marconi, Vincent C. Dolan, Matthew J. Agan, Brian K. CA Infect Dis Clinical Res Program TI Hepatitis B vaccination and risk of hepatitis B infection in HIV-infected individuals SO AIDS LA English DT Article DE hepatitis B vaccine; hepatitis B virus; human immunodeficiency virus; immunization; vaccination ID HUMAN-IMMUNODEFICIENCY-VIRUS; LONG-TERM IMMUNOGENICITY; T-CELL RESPONSES; HOMOSEXUAL-MEN; ANTIRETROVIRAL THERAPY; UNITED-STATES; EFFICACY; ANTIBODY; COHORT; TRIAL AB Objective: To assess the association of hepatitis B virus (HBV) vaccination with risk of HBV infection among HIV-infected patients and HBV infection risk factors among vaccinees. Design: Observational cohort study. Methods: Participants enrolled from 1986 through 2004, unvaccinated and serologically negative for HBV infection at the time of HIV diagnosis, were followed longitudinally through 2007 for the occurrence of HBV infection. Risk factors for HBV infection were evaluated using time to event methods, including Kaplan-Meier survival curves and Cox proportional hazards models. Results: During 11 632 person-years of follow-up, the rate of HBV infection was 2.01 (95% CI 1.75-2.27)/100 person-years. Receipt of at least one dose of vaccine was not associated with reduced risk of HBV (unadjusted hazard ratio 0.86, 95% CI 0.7-1.1; adjusted hazard ratio 1.08, 95% CI 0.8-1.4). Receipt of three or more doses of vaccine was also not associated with reduced risk (hazard ratio 0.96; 95% CI 0.56-1.64). Among 409 vaccinees with HBsAb less than 10 IU/l, 46 (11.2%) developed HBV infection compared with 11 of 217 (5.1%) vaccinees with HBsAb >= 10 IU/l (hazard ratio 0.51; 95% CI 0.3-1.0). In participants with initial HBsAb less than 10 IU/l, 16 of 46 (35%) infections were chronic, compared with none of 11 in those with initial HBsAb at least 10 IU/l (P = 0.02). Conclusion: Overall, HBV vaccination was not associated with reduced risk of HBV infection in our cohort of HIV-infected individuals. However, the small subset of vaccinees with a positive vaccine response may have had reduced HBV infection risk, including chronic disease. Improvements in vaccine delivery and immunogenicity are needed to increase HBV vaccine effectiveness in HIV-infected patients. (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins C1 [Landrum, Michael L.; Marconi, Vincent C.; Dolan, Matthew J.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Landrum, Michael L.; Hullsiek, Katherine Huppler; Ganesan, Anuradha; Weintrob, Amy C.; Crum-Cianflone, Nancy F.; O'Connell, Robert J.; Fieberg, Ann; Marconi, Vincent C.; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD USA. [Hullsiek, Katherine Huppler; Fieberg, Ann] Univ Minnesota, Minneapolis, MN USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Bethesda, MD USA. [Weintrob, Amy C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Crum-Cianflone, Nancy F.] Naval Med Ctr, San Diego, CA USA. [Barthel, R. Vincent] Naval Med Ctr, Portsmouth, VA USA. [O'Connell, Robert J.] Walter Reed Army Inst Res, Div Retrovirol, Silver Spring, MD USA. [Chun, Helen M.] Naval Hlth Res Ctr, San Diego, CA USA. RP Landrum, ML (reprint author), Brooke Army Med Ctr, Infect Dis Serv, MCHE MDI, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM mlandrum@idcrp.org RI Marconi, Vincent/N-3210-2014; OI Marconi, Vincent/0000-0001-8409-4689; Agan, Brian/0000-0002-5114-1669 FU NIAID NIH HHS [HU0001-05-2-0011]; PHS HHS [HU0001-05-2-0011] NR 54 TC 25 Z9 25 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 J9 AIDS JI Aids PD FEB 20 PY 2010 VL 24 IS 4 BP 545 EP 555 DI 10.1097/QAD.0b013e32832cd99e PG 11 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 563QK UT WOS:000275148000007 PM 19487908 ER PT J AU Foley, DH Wilkerson, RC Birney, I Harrison, S Christensen, J Rueda, LM AF Foley, Desmond H. Wilkerson, Richard C. Birney, Ian Harrison, Stanley Christensen, Jamie Rueda, Leopoldo M. TI MosquitoMap and the Mal-area calculator: new web tools to relate mosquito species distribution with vector borne disease SO INTERNATIONAL JOURNAL OF HEALTH GEOGRAPHICS LA English DT Article ID MALARIA TRANSMISSION AB Background: Mosquitoes are important vectors of diseases but, in spite of various mosquito faunistic surveys globally, there is a need for a spatial online database of mosquito collection data and distribution summaries. Such a resource could provide entomologists with the results of previous mosquito surveys, and vector disease control workers, preventative medicine practitioners, and health planners with information relating mosquito distribution to vector-borne disease risk. Results: A web application called MosquitoMap was constructed comprising mosquito collection point data stored in an ArcGIS 9.3 Server/SQL geodatabase that includes administrative area and vector species x country lookup tables. In addition to the layer containing mosquito collection points, other map layers were made available including environmental, and vector and pathogen/disease distribution layers. An application within MosquitoMap called the Mal-area calculator (MAC) was constructed to quantify the area of overlap, for any area of interest, of vector, human, and disease distribution models. Data standards for mosquito records were developed for MosquitoMap. Conclusion: MosquitoMap is a public domain web resource that maps and compares georeferenced mosquito collection points to other spatial information, in a geographical information system setting. The MAC quantifies the Mal-area, i.e. the area where it is theoretically possible for vector-borne disease transmission to occur, thus providing a useful decision tool where other disease information is limited. The Mal-area approach emphasizes the independent but cumulative contribution to disease risk of the vector species predicted present. MosquitoMap adds value to, and makes accessible, the results of past collecting efforts, as well as providing a template for other arthropod spatial databases. C1 [Foley, Desmond H.; Wilkerson, Richard C.; Rueda, Leopoldo M.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA. [Birney, Ian; Harrison, Stanley; Christensen, Jamie] Worldview Solut Inc, Richmond, VA 23219 USA. RP Foley, DH (reprint author), Walter Reed Army Inst Res, Div Entomol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM foleydes@si.edu RI Valle, Ruben/A-7512-2013; OI Foley, Desmond/0000-0001-7525-4601 NR 17 TC 15 Z9 15 U1 2 U2 11 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1476-072X J9 INT J HEALTH GEOGR JI Int. J. Health Geogr. PD FEB 18 PY 2010 VL 9 AR 11 DI 10.1186/1476-072X-9-11 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 570QO UT WOS:000275693200001 PM 20167090 ER PT J AU Rueda, LM Brown, TL Kim, HC Chong, ST Klein, TA Foley, DH Anyamba, A Smith, M Pak, EP Wilkerson, RC AF Rueda, Leopoldo M. Brown, Tracy L. Kim, Heung Chul Chong, Sung-Tae Klein, Terry A. Foley, Desmond H. Anyamba, Assaf Smith, Matthew Pak, Edwin P. Wilkerson, Richard C. TI Species composition, larval habitats, seasonal occurrence and distribution of potential malaria vectors and associated species of Anopheles (Diptera: Culicidae) from the Republic of Korea SO MALARIA JOURNAL LA English DT Article ID ECOLOGICAL CONDITIONS; SATELLITE DATA; IMAGERY; KENYA AB Background: Larval mosquito habitats of potential malaria vectors and related species of Anopheles from three provinces (Gyeonggi, Gyeongsangbuk, Chungcheongbuk Provinces) of the Republic of Korea were surveyed in 2007. This study aimed to determine the species composition, seasonal occurrence and distributions of Anopheles mosquitoes. Satellite derived normalized difference vegetation index data (NDVI) was also used to study the seasonal abundance patterns of Anopheles mosquitoes. Methods: Mosquito larvae from various habitats were collected using a standard larval dipper or a white plastic larval tray, placed in plastic bags, and were preserved in 100% ethyl alcohol for species identification by PCR and DNA sequencing. The habitats in the monthly larval surveys included artificial containers, ground depressions, irrigation ditches, drainage ditches, ground pools, ponds, rice paddies, stream margins, inlets and pools, swamps, and uncultivated fields. All field-collected specimens were identified to species, and relationships among habitats and locations based on species composition were determined using cluster statistical analysis. Results: In about 10,000 specimens collected, eight species of Anopheles belonging to three groups were identified: Hyrcanus Group - Anopheles sinensis, Anopheles kleini, Anopheles belenrae, Anopheles pullus, Anopheles lesteri, Anopheles sineroides; Barbirostris Group - Anopheles koreicus; and Lindesayi Group - Anopheles lindesayi japonicus. Only An. sinensis was collected from all habitats groups, while An. kleini, An. pullus and An. sineroides were sampled from all, except artificial containers. The highest number of Anopheles larvae was found in the rice paddies (34.8%), followed by irrigation ditches (23.4%), ponds (17.0%), and stream margins, inlets and pools (12.0%). Anopheles sinensis was the dominant species, followed by An. kleini, An. pullus and An. sineroides. The monthly abundance data of the Anopheles species from three locations (Munsan, Jinbo and Hayang) were compared against NDVI and NDVI anomalies. Conclusion: The species composition of Anopheles larvae varied in different habitats at various locations. Anopheles populations fluctuated with the seasonal dynamics of vegetation for 2007. Multi-year data of mosquito collections are required to provide a better characterization of the abundance of these insects from year to year, which can potentially provide predictive capability of their population density based on remotely sensed ecological measurements. C1 [Rueda, Leopoldo M.; Brown, Tracy L.; Foley, Desmond H.; Wilkerson, Richard C.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA. [Rueda, Leopoldo M.; Brown, Tracy L.; Foley, Desmond H.; Wilkerson, Richard C.] Smithsonian Inst, Museum Support Ctr, WRAIR, Walter Reed Biosystemat Unit, Suitland, MD 20746 USA. [Kim, Heung Chul; Chong, Sung-Tae] Unit 15247, APO, AP 96205 USA. [Klein, Terry A.] Unit 15281, USAMEDDAC Korea, APO, AP 96205 USA. [Anyamba, Assaf; Smith, Matthew; Pak, Edwin P.] NASA, Goddard Space Flight Ctr, Biospher Sci Branch, Greenbelt, MD 20771 USA. RP Rueda, LM (reprint author), Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA. EM ruedapol@si.edu RI Valle, Ruben/A-7512-2013; OI Foley, Desmond/0000-0001-7525-4601 FU Center for Health Promotion and Preventive Medicine; Global Emerging Infections Surveillance and Response Systems, Silver Spring, MD; Walter Reed Army Institute of Research; Smithsonian Institution FX Thanks go to A. Driskell and G. Harrison (Laboratory of Analytical Biology, Smithsonian Institution) for conducting PCR/sequencing of some mosquito samples; personnel of the 5th Medical Detachment, and staff of 65th Medical Brigade, U. S. Army, ROK, for field collections of mosquito specimens; and J. Pecor and WRBU staff for curatorial help. Special thanks go to D. J. Brambilla (Research Triangle Institute, Research Triangle Park, NC) for statistical analysis; and G. Bieler (RTP, NC), C. Lim (WRAIR) and V. Sherwood (WRAIR) for statistical and related support. We are grateful to F. Ruiz, C. R. Summers and B. P. Rueda for helpful reviews of the manuscript. Funding for this work was provided by the Center for Health Promotion and Preventive Medicine, Global Emerging Infections Surveillance and Response Systems, Silver Spring, MD. This research was performed under a Memorandum of Understanding between the Walter Reed Army Institute of Research and the Smithsonian Institution, with institutional support provided by both organizations. The opinions and assertions contained herein are those of the authors and are not to be construed as official or reflecting the views of the Department of the Army or the Department of Defense. NR 27 TC 14 Z9 14 U1 0 U2 8 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD FEB 17 PY 2010 VL 9 AR 55 DI 10.1186/1475-2875-9-55 PG 11 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 567RI UT WOS:000275463900002 PM 20163728 ER PT J AU Wolf, MC Freiberg, AN Zhang, TH Akyol-Ataman, Z Grock, A Hong, PW Li, JR Watson, NF Fang, AQ Aguilar, HC Porotto, M Honko, AN Damoiseaux, R Miller, JP Woodson, SE Chantasirivisal, S Fontanes, V Negrete, OA Krogstad, P Dasgupta, A Moscona, A Hensley, LE Whelan, SP Faull, KF Holbrook, MR Jung, ME Lee, B AF Wolf, Mike C. Freiberg, Alexander N. Zhang, Tinghu Akyol-Ataman, Zeynep Grock, Andrew Hong, Patrick W. Li, Jianrong Watson, Natalya F. Fang, Angela Q. Aguilar, Hector C. Porotto, Matteo Honko, Anna N. Damoiseaux, Robert Miller, John P. Woodson, Sara E. Chantasirivisal, Steven Fontanes, Vanessa Negrete, Oscar A. Krogstad, Paul Dasgupta, Asim Moscona, Anne Hensley, Lisa E. Whelan, Sean P. Faull, Kym F. Holbrook, Michael R. Jung, Michael E. Lee, Benhur TI A broad-spectrum antiviral targeting entry of enveloped viruses SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE virology; viral entry; fusion inhibitor; small molecule; lipid membrane ID PLASMA-MEMBRANE; NIPAH-VIRUS; IN-VITRO; CELL-FUSION; MECHANISMS; PEPTIDE; LYSOPHOSPHATIDYLCHOLINE; PARAMYXOVIRUS; GLYCOPROTEINS; CURVATURE AB We describe an antiviral small molecule, LJ001, effective against numerous enveloped viruses including Influenza A, filoviruses, poxviruses, arenaviruses, bunyaviruses, paramyxoviruses, flaviviruses, and HIV-1. In sharp contrast, the compound had no effect on the infection of nonenveloped viruses. In vitro and in vivo assays showed no overt toxicity. LJ001 specifically intercalated into viral membranes, irreversibly inactivated virions while leaving functionally intact envelope proteins, and inhibited viral entry at a step after virus binding but before virus-cell fusion. LJ001 pretreatment also prevented virus-induced mortality from Ebola and Rift Valley fever viruses. Structure-activity relationship analyses of LJ001, a rhodanine derivative, implicated both the polar and nonpolar ends of LJ001 in its antiviral activity. LJ001 specifically inhibited virus-cell but not cell-cell fusion, and further studies with lipid biosynthesis inhibitors indicated that LJ001 exploits the therapeutic window that exists between static viral membranes and biogenic cellular membranes with reparative capacity. In sum, our data reveal a class of broad-spectrum antivirals effective against enveloped viruses that target the viral lipid membrane and compromises its ability to mediate virus-cell fusion. C1 [Wolf, Mike C.; Akyol-Ataman, Zeynep; Grock, Andrew; Hong, Patrick W.; Watson, Natalya F.; Fang, Angela Q.; Aguilar, Hector C.; Chantasirivisal, Steven; Fontanes, Vanessa; Negrete, Oscar A.; Dasgupta, Asim; Lee, Benhur] Univ Calif Los Angeles, Dept Microbiol Mol Genet & Immunol, Los Angeles, CA 90025 USA. [Zhang, Tinghu; Faull, Kym F.; Jung, Michael E.] Univ Calif Los Angeles, Dept Chem, Los Angeles, CA 90025 USA. [Miller, John P.; Krogstad, Paul] Univ Calif Los Angeles, Dept Med & Mol Pharmacol, Los Angeles, CA 90025 USA. [Lee, Benhur] Univ Calif Los Angeles, Dept Pathol, Los Angeles, CA 90025 USA. [Lee, Benhur] Univ Calif Los Angeles, Los Angeles AIDS Inst, Los Angeles, CA 90025 USA. [Freiberg, Alexander N.; Woodson, Sara E.; Holbrook, Michael R.] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA. [Li, Jianrong; Whelan, Sean P.] Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA. [Honko, Anna N.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Porotto, Matteo; Moscona, Anne] Cornell Univ, Weill Med Coll, New York, NY 10021 USA. RP Lee, B (reprint author), Univ Calif Los Angeles, Dept Microbiol Mol Genet & Immunol, Los Angeles, CA 90025 USA. EM bleebhl@ucla.edu RI Damoiseaux, Robert/F-1086-2011; Li, Jianrong/E-3510-2011; Lee, Benhur/A-8554-2016; OI Damoiseaux, Robert/0000-0002-7611-7534; Lee, Benhur/0000-0003-0760-1709; Honko, Anna/0000-0001-9165-148X FU National Institutes of Health [AI065359, AI069317, AI070495, AI082100]; UCLA Center for Aids Research [AI028697]; Burroughs Wellcome Fund; March of Dimes; California NanoSystems Institute; UCLA Microbial Pathogenesis [AI07323]; Warsaw Fellowship Endowment; Rheumatology Training Grant [AR053463] FX We thank D. Nayak and S. Barman for Influenza A testing, T. S. Dermody for Reovirus T3D, Peter Palese for rNDV-GFP, and K. Esham and J.C. Johnson (US Army Medical Research Institute of Infectious Diseases) for BSL-4 assistance. We also thank I.S.Y. Chen, R. W. Doms, and K. A. Bradley for thoughtful discussion and members of the Lee laboratory, and especially F. Vigant, for both thoughtful conversation and review of the manuscript. This work was supported by National Institutes of Health Grants AI065359, AI069317, AI070495, and AI082100 (to B. L.), UCLA Center for Aids Research Grant AI028697, the Burroughs Wellcome Fund (B. L., S. P. W.), a March of Dimes Research Grant (to A. M.), the California NanoSystems Institute (R. D.), UCLA Microbial Pathogenesis Training Grant AI07323, a Warsaw Fellowship Endowment (M. C. W.), and Rheumatology Training Grant AR053463 (to P. W. H.). NR 33 TC 114 Z9 118 U1 2 U2 22 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD FEB 16 PY 2010 VL 107 IS 7 BP 3157 EP 3162 DI 10.1073/pnas.0909587107 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 556OC UT WOS:000274599500081 PM 20133606 ER PT J AU Moawad, FJ Veerappan, GR Lake, JM Maydonovitch, CL Haymore, BR Kosisky, SE Wong, RKH AF Moawad, F. J. Veerappan, G. R. Lake, J. M. Maydonovitch, C. L. Haymore, B. R. Kosisky, S. E. Wong, R. K. H. TI Correlation between eosinophilic oesophagitis and aeroallergens SO ALIMENTARY PHARMACOLOGY & THERAPEUTICS LA English DT Article ID SKIN PRICK; FOOD ALLERGY; PATCH TESTS; CHILDREN; PATHOGENESIS; DIAGNOSIS; MUCOSA; POLLEN; ADULTS; DIET AB Background Aeroallergens have been implicated in the pathogenesis of eosinophilic oesophagitis. Aim To determine whether a seasonal variation exists in the diagnoses of eosinophilic oesophagitis and whether there is a correlation with seasonal pollen count. Methods A retrospective review was performed from January 2006 to November 2008 to identify eosinophilic oesophagitis patients. Cases were classified by endoscopic date. Daily pollen counts for grass, trees and weeds were obtained from a certified counting station. Per cent of eosinophilic oesophagitis cases were collated seasonally and compared with mean pollen counts for grass, trees and weeds during the same time period. Results A total of 127 eosinophilic oesophagitis cases were identified (median age 41, range 19-92 years, 84% men). The highest percentage of cases (33.0%; Binomial P = 0.022) was diagnosed in the spring, while the least percentage (16%; Binomial P = 0.0.010) occurred in the winter. There was a significant association between per cent eosinophilic oesophagitis cases diagnosed seasonally and mean grass pollen count (rs = 1.000, P < 0.01), but not with trees (rs = 0.400, P = 0.600) or weeds (rs = 0.800, P = 0.200). Conclusions A seasonal variation was seen in the diagnosis of eosinophilic oesophagitis which correlated with pollen counts. These findings have important implications regarding the pathogenesis of eosinophilic oesophagitis, suggesting a potential role for aeroallergens. C1 [Moawad, F. J.; Veerappan, G. R.; Lake, J. M.; Maydonovitch, C. L.; Wong, R. K. H.] Walter Reed Army Med Ctr, Gastroenterol Serv, Dept Med, Washington, DC 20307 USA. [Haymore, B. R.; Kosisky, S. E.] Walter Reed Army Med Ctr, Gastroenterol Serv, Allergy & Immunol Serv, Washington, DC 20307 USA. RP Moawad, FJ (reprint author), Walter Reed Army Med Ctr, Gastroenterol Serv, Dept Med, 6900 Georgia Ave, Washington, DC 20307 USA. EM fouad.moawad@amedd.army.mil NR 26 TC 85 Z9 90 U1 0 U2 2 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0269-2813 J9 ALIMENT PHARM THER JI Aliment. Pharmacol. Ther. PD FEB 15 PY 2010 VL 31 IS 4 BP 509 EP 515 DI 10.1111/j.1365-2036.2009.04199.x PG 7 WC Gastroenterology & Hepatology; Pharmacology & Pharmacy SC Gastroenterology & Hepatology; Pharmacology & Pharmacy GA 543SF UT WOS:000273598000006 PM 19925501 ER PT J AU Milner, E McCalmont, W Bhonsle, J Caridha, D Carroll, D Gardner, S Gerena, L Gettayacamin, M Lanteri, C Luong, T Melendez, V Moon, J Roncal, N Sousa, J Tungtaeng, A Wipf, P Dow, G AF Milner, Erin McCalmont, William Bhonsle, Jayendra Caridha, Diana Carroll, Dustin Gardner, Sean Gerena, Lucia Gettayacamin, Montip Lanteri, Charlotte Luong, ThuLan Melendez, Victor Moon, Jay Roncal, Norma Sousa, Jason Tungtaeng, Anchalee Wipf, Peter Dow, Geoffrey TI Structure-activity relationships amongst 4-position quinoline methanol antimalarials that inhibit the growth of drug sensitive and resistant strains of Plasmodium falciparum SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS LA English DT Article DE Antimalarials; Plasmodium falciparum; Plasmodium berghei; Mefloquine; Quinoline methanol; Structure-activity relationship ID P-GLYCOPROTEIN; MEFLOQUINE; MALARIA AB Utilizing mefloquine as a scaffold, a next generation quinoline methanol (NGQM) library was constructed to identify early lead compounds that possess biological properties consistent with the target product pro. le for malaria chemoprophylaxis while reducing permeability across the blood-brain barrier. The library of 200 analogs resulted in compounds that inhibit the growth of drug sensitive and resistant strains of Plasmodium falciparum. Herein we report selected chemotypes and the emerging structure activity relationship for this library of quinoline methanols. Published by Elsevier Ltd. C1 [Milner, Erin; McCalmont, William; Bhonsle, Jayendra; Caridha, Diana; Carroll, Dustin; Gardner, Sean; Gerena, Lucia; Lanteri, Charlotte; Luong, ThuLan; Melendez, Victor; Moon, Jay; Roncal, Norma; Sousa, Jason; Dow, Geoffrey] Walter Reed Army Inst Res, Silver Spring, MD USA. [Gettayacamin, Montip; Tungtaeng, Anchalee] Armed Forces Res Inst Med Sci, US Army Med Component, Bangkok 10400, Thailand. [Wipf, Peter] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA. RP Milner, E (reprint author), Walter Reed Army Inst Res, Silver Spring, MD USA. EM erin.milner@us.army.mil RI Sousa, Jason/A-9177-2011; Luong, Thu-Lan/A-9160-2011 FU Military Infectious Diseases Research Program (MIDRP) FX We thank the - for financial support. NR 19 TC 26 Z9 26 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0960-894X J9 BIOORG MED CHEM LETT JI Bioorg. Med. Chem. Lett. PD FEB 15 PY 2010 VL 20 IS 4 BP 1347 EP 1351 DI 10.1016/j.bmcl.2010.01.001 PG 5 WC Chemistry, Medicinal; Chemistry, Organic SC Pharmacology & Pharmacy; Chemistry GA 552JJ UT WOS:000274285600006 PM 20097070 ER PT J AU Lee, J Feng, X Faiia, AM Posmentier, ES Kirchner, JW Osterhuber, R Taylor, S AF Lee, Jeonghoon Feng, Xiahong Faiia, Anthony M. Posmentier, Eric S. Kirchner, James W. Osterhuber, Randall Taylor, Susan TI Isotopic evolution of a seasonal snowcover and its melt by isotopic exchange between liquid water and ice SO CHEMICAL GEOLOGY LA English DT Article DE Snowmelt; Isotopic exchange between liquid and ice; Isotopic heterogeneity of a snowpack ID ONE-DIMENSIONAL MODEL; STABLE-ISOTOPES; HYDROGRAPH SEPARATION; FRACTIONATION; SNOWPACK; SNOWMELT; PRECIPITATION; DELTA-O-18; EVAPORATION; STREAMFLOW AB Understanding an isotopic evolution of a snowpack is important for both climate and hydrological studies, because the snowmelt is a significant component of groundwater and surface runoff in temperate areas. In this work, we studied oxygen and hydrogen isotopic evolution from new snow to snow profile and to meltwater through two winter seasons (1998 and 2001) at the Central Sierra Snow Laboratory, California, USA. The slopes of the delta D vs. delta(18)O regression for the new snow are similar to that of the global meteoric water line (GMWL) of 8. However, this slope decreases in the snow profile and decreases further in the meltwater. We attribute this systematic slope changes to the isotopic exchange between ice and liquid water that is generated at the snow surface by melting and flows through the snowpack by percolation. A physically-based one-dimensional model, including melting of snow at the surface and isotopic exchange between percolating water and ice, was used to simulate isotopic variation of snowmelt in 2001. A successful simulation was obtained for the delta D-delta(18)O slope of snowmelt (6.5), which is significantly lower than the slope of the meteoric water line (8.2) defined by the new snow. This result indicates that the liquid water evaporation should not be considered as the only process that yields slopes of the delta D vs. delta(18)O relationship in surface water and groundwater. The d-excess of the snowmelt is changed from the original snow because of the delta D-delta(18)O relationship controlled by ice-liquid exchange. With a delta D-delta(18)O slope less than 8, the d-excess would be anti-correlated with delta D or delta(18)O. The model is also used to examine how isotopic heterogeneity of a snowpack affects the isotopic redistribution in the pore water, ice and meltwater of the snowpack. The results show that isotopic heterogeneity of the snowpack may significantly affect the temporal changes in the delta D-delta(18)O slopes, and a measured slope at a given time is a combined result of meteorological conditions, which affect both isotopic composition of the original snow and the process of snow metamorphism, and the melting history of the snowpack. (C) 2009 Elsevier B.V. All rights reserved. C1 [Lee, Jeonghoon; Feng, Xiahong; Faiia, Anthony M.; Posmentier, Eric S.] Dartmouth Coll, Dept Earth Sci, Hanover, NH 03755 USA. [Kirchner, James W.] Univ Calif Berkeley, Dept Earth & Planetary Sci, Berkeley, CA 94720 USA. [Kirchner, James W.] Swiss Fed Inst Forest Snow & Landscape Res WSL, CH-8903 Birmensdorf, Switzerland. [Kirchner, James W.] Swiss Fed Inst Technol, CH-8092 Zurich, Switzerland. [Osterhuber, Randall] Cent Sierra Snow Lab, Soda Springs, CA 95728 USA. [Taylor, Susan] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Lee, J (reprint author), Dartmouth Coll, Dept Earth Sci, Hanover, NH 03755 USA. EM jeonghoon.lee@jpl.nasa.gov RI Lee, Jeonghoon/E-8116-2010; Kirchner, James/B-6126-2009 OI Lee, Jeonghoon/0000-0002-1256-4431; Kirchner, James/0000-0001-6577-3619 FU National Science Foundation [EAR-9903281, EAR-0111403, EAR-0418809]; Dartmouth College FX This research was partially supported by the National Science Foundation (EAR-9903281, EAR-0111403, and EAR-0418809) and by Dartmouth College. NR 39 TC 20 Z9 20 U1 4 U2 37 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2541 J9 CHEM GEOL JI Chem. Geol. PD FEB 15 PY 2010 VL 270 IS 1-4 BP 126 EP 134 DI 10.1016/j.chemgeo.2009.11.011 PG 9 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 561PH UT WOS:000274989800012 ER PT J AU Liu, G Talley, JW Na, CZ Larson, SL Wolfe, LG AF Liu, Guojing Talley, Jeffrey W. Na, Chongzheng Larson, Steve L. Wolfe, Lawrence G. TI Copper Doping Improves Hydroxyapatite Sorption for Arsenate in Simulated Groundwaters SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID INORGANIC CATION-EXCHANGERS; ZERO-VALENT IRON; SYNTHETIC HYDROXYAPATITES; AQUEOUS-SOLUTIONS; ARSENITE REMOVAL; MINERAL APATITE; IONS; REMEDIATION; IMMOBILIZATION; ADSORPTION AB Hydroxyapatite (HAP) has been widely used to immobilize many cationic heavy metals in water and soils. Compared with its strong sorption for metal cations, the abilities of HAP to sorb metal anions, such as arsenic, are less significant. Improving HAP sorption for anionic arsenic species is important for expanding its application potential because the presence of arsenic in the environment has raised serious health concerns and there is need for cost-effective remediation methods. In this work, we report an innovative method of copper doping to improve a synthetic HAP sorption for arsenate, which is a primary aqueous arsenic species, in simulated groundwaters. The undoped HAP and copper doped HAP (CuHAP) were characterized with XRD, FTIR, N(2) adsorption, and SEM, and then evaluated as sorbents for arsenate removal tests. The experimental results suggest that copper doping changed the morphology and increased the surface area of HAP. The CuHAP sorbed 1.6-9.1 x more arsenate than the undoped HAP did in a simulated groundwater at pH of 7.7-8.0. The improved arsenate sorption is presumably due to the increase in surface area of HAP as a result of copper doping. In addition to the copper doping level, the arsenate sorption to HAP and CuHAP can also be increased with increasing water pH and calcium concentration. The experimental data indicate that sorbent dissolution is an important factor governing arsenate sorption to HAP and CuHAP. C1 Dept Civil Engn & Geol Sci, Notre Dame, IN 46556 USA. Dept Environm & Civil Engn, Dallas, TX 75205 USA. [Larson, Steve L.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Liu, G (reprint author), Univ Notre Dame, Notre Dame, IN 46556 USA. EM liuguojing@gmail.com; jtalley@lyle.smu.edu FU University of Notre Dame Faculty Scholarship Award Program FX We thank the Center of Environmental Science and Technology (CEST), the Environmental Molecular Scientific Institute (EMS]), and the Environmental Mineralogy and Crystal Structures Lab at the University of Notre Dame for providing the necessary instrumentation for this study. C.N. thanks the generous support by the University of Notre Dame Faculty Scholarship Award Program. NR 37 TC 22 Z9 23 U1 6 U2 62 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD FEB 15 PY 2010 VL 44 IS 4 BP 1366 EP 1372 DI 10.1021/es9015734 PG 7 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 553EC UT WOS:000274347800034 PM 20095528 ER PT J AU Vahey, MT Wang, ZN Kester, KE Cummings, J Heppner, DG Nau, ME Ofori-Anyinam, O Cohen, J Coche, T Ballou, WR Ockenhouse, CF AF Vahey, Maryanne T. Wang, Zhining Kester, Kent E. Cummings, James Heppner, D. Gray, Jr. Nau, Martin E. Ofori-Anyinam, Opokua Cohen, Joe Coche, Thierry Ballou, W. Ripley Ockenhouse, Christian F. TI Expression of Genes Associated with Immunoproteasome Processing of Major Histocompatibility Complex Peptides Is Indicative of Protection with Adjuvanted RTS,S Malaria Vaccine SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID FALCIPARUM CIRCUMSPOROZOITE-PROTEIN; INSTITUTE-OF-RESEARCH; YELLOW-FEVER VACCINE; PHASE 2A TRIAL; PLASMODIUM-FALCIPARUM; BREAST-CANCER; NAIVE ADULTS; ANTIGEN PRESENTATION; IMMUNE-RESPONSES; RHESUS MACAQUES AB Background. Patterns of expressed genes in the peripheral blood mononuclear cells of persons who were receiving RTS,S/AS01 or RTS,S/AS02 malaria vaccine and were undergoing experimental challenge with mosquito-borne falciparum malaria were examined to identify markers associated with protection. Methods. Thirty-nine vaccine recipients were assessed at study entry; on the day of the third vaccination; at 24 h, 72 h, and 2 weeks after vaccination; and on day 5 after challenge. Of 39 vaccine recipients, 13 were protected and 26 were not. Eleven vaccine recipients exhibited delayed onset of parasitemia. All infectivity control subjects developed parasitemia. Prediction analysis of microarrays identified genes corresponding with protection. Gene set enrichment analysis identified sets of genes associated with protection after the third vaccination and before challenge. Results. After the third vaccination and before challenge, differential expression of genes in the immunoproteasome pathway distinguished protected and nonprotected persons. At 5 days after challenge, differential expression of genes associated with programmed cell death distinguished between subjects protected and not protected from malaria blood-stage infection. Conclusions. The up-regulation of genes associated with the efficient processing of major histocompatibility complex peptides suggests a potential role of the vaccine in conferring major histocompatibility complex class 1 mediated protection and may represent a useful surrogate marker of vaccine efficacy without the need for challenge. C1 [Vahey, Maryanne T.; Kester, Kent E.; Cummings, James; Heppner, D. Gray, Jr.; Ockenhouse, Christian F.] Walter Reed Army Inst Res, Silver Spring, MD 20403 USA. [Wang, Zhining; Nau, Martin E.] Henry M Jackson Fdn Adv Mil Med, Rockville, MD USA. [Ballou, W. Ripley] Bill & Melinda Gates Fdn, Seattle, WA USA. [Ofori-Anyinam, Opokua; Cohen, Joe; Coche, Thierry] GlaxoSmithKline Biol, Rixensart, Belgium. RP Vahey, MT (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20403 USA. EM maryanne.vahey@us.army.mil RI Kester, Kent/A-2114-2011 OI Kester, Kent/0000-0002-5056-0802 NR 38 TC 39 Z9 39 U1 0 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD FEB 15 PY 2010 VL 201 IS 4 BP 580 EP 589 DI 10.1086/650310 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 546WF UT WOS:000273843900015 PM 20078211 ER PT J AU Kibuuka, H Kimutai, R Maboko, L Sawe, F Schunk, MS Kroidl, A Shaffer, D Eller, LA Kibaya, R Eller, MA Schindler, KB Schuetz, A Millard, M Kroll, J Dally, L Hoelscher, M Bailer, R Cox, JH Marovich, M Birx, DL Graham, BS Michael, NL de Souza, MS Robb, ML AF Kibuuka, Hannah Kimutai, Robert Maboko, Leonard Sawe, Fred Schunk, Mirjam S. Kroidl, Arne Shaffer, Douglas Eller, Leigh Anne Kibaya, Rukia Eller, Michael A. Schindler, Karin B. Schuetz, Alexandra Millard, Monica Kroll, Jason Dally, Len Hoelscher, Michael Bailer, Robert Cox, Josephine H. Marovich, Mary Birx, Deborah L. Graham, Barney S. Michael, Nelson L. de Souza, Mark S. Robb, Merlin L. TI A Phase 1/2 Study of a Multiclade HIV-1 DNA Plasmid Prime and Recombinant Adenovirus Serotype 5 Boost Vaccine in HIV-Uninfected East Africans (RV 172) SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID IMMUNODEFICIENCY VIRUS CHALLENGE; MEMORY T-CELLS; CANDIDATE VACCINE; AIDS VACCINE; DOUBLE-BLIND; INFECTION; TRIAL; SURVIVAL; IMMUNITY; MONKEYS AB Background. Human immunodeficiency virus (HIV) vaccine development remains a global priority. We describe the safety and immunogenicity of a multiclade DNA vaccine prime with a replication-defective recombinant adenovirus serotype 5 (rAd5) boost. Methods. The vaccine is a 6-plasmid mixture encoding HIV envelope (env) subtypes A, B, and C and subtype B gag, pol, and nef, and an rAd5 expressing identical genes, with the exception of nef. Three hundred and twenty-four participants were randomized to receive placebo (n = 138), a single dose of rAd5 at 10(10) (n = 24) or 10(11) particle units (n = 24), or DNA at 0, 1, and 2 months, followed by rAd5 at either 10(10) (n = 114) or 10(11) particle units (n = 24) boosting at 6 months. Participants were followed up for 24 weeks after the final vaccination. Results. The vaccine was safe and well tolerated. HIV-specific T cell responses were detected in 63% of vaccinees. Titers of preexisting Ad5 neutralizing antibody did not affect the frequency and magnitude of T cell responses in prime-boost recipients but did affect the response rates in participants that received rAd5 alone (P = .037). Conclusion. The DNA/rAd5 vaccination regimen was safe and induced HIV type 1 multi-clade T cell responses, which were not significantly affected by titers of preexisting rAd5 neutralizing antibody. C1 [Kibuuka, Hannah; Eller, Leigh Anne; Eller, Michael A.; Millard, Monica] Makerere Univ, Walter Reed Project, Kampala, Uganda. [Kimutai, Robert; Sawe, Fred; Shaffer, Douglas; Kibaya, Rukia] US Army Med Res Unit Kenya, Walter Reed Project, Kericho, Kenya. [Maboko, Leonard; Schunk, Mirjam S.; Kroidl, Arne; Schindler, Karin B.; Schuetz, Alexandra; Hoelscher, Michael] Mbeya Med Res Programme, Mbeya, Tanzania. [Schunk, Mirjam S.; Kroidl, Arne; Schindler, Karin B.; Schuetz, Alexandra; Hoelscher, Michael] Klinikum Ludwigs Maximilians Univ, Munich, Germany. [Eller, Leigh Anne; Eller, Michael A.; Marovich, Mary; Michael, Nelson L.; de Souza, Mark S.; Robb, Merlin L.] US Mil, HIV Res Program, Rockville, MD USA. [Kroll, Jason; Dally, Len] Emmes Corp, Rockville, MD USA. [Bailer, Robert; Graham, Barney S.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [Cox, Josephine H.] Int AIDS Vaccine Initiat, New York, NY USA. [Birx, Deborah L.] Ctr Dis Control & Prevent, Atlanta, GA USA. [de Souza, Mark S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Robb, ML (reprint author), 1600 Gude Dr, Rockville, MD 20850 USA. EM mrobb@hivresearch.org RI Hoelscher, Michael/D-3436-2012 FU NIAID NIH HHS [Y01 AI2642-12] NR 24 TC 70 Z9 71 U1 0 U2 3 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD FEB 15 PY 2010 VL 201 IS 4 BP 600 EP 607 DI 10.1086/650299 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 546WF UT WOS:000273843900017 PM 20078213 ER PT J AU Zhang, SS Foster, D Read, J AF Zhang, Sheng S. Foster, Donald Read, Jeffrey TI Discharge characteristic of a non-aqueous electrolyte Li/O-2 battery SO JOURNAL OF POWER SOURCES LA English DT Article DE Metal/air battery; Li/air battery; Air electrode; Oxygen reduction; Non-aqueous electrolyte ID ORGANIC ELECTROLYTE; LITHIUM/OXYGEN BATTERY; ALKALINE-SOLUTION; OXYGEN REDUCTION; ACTIVATED CARBON; AIR BATTERIES; CATHODES AB Discharge characteristic of Li/O-2 cells was studied using galvanostatic discharge, polarization. and ac-impedance techniques. Results show that the discharge performance of Li/O-2 cells is determined mainly by the carbon air electrode, instead by the Li anode. A consecutive polarization experiment shows that impedance of the air electrode is progressively increased with polarization cycle number since the surfaces of the air electrode are gradually covered by discharge products, which prevents oxygen from diffusing to the reaction sites of carbon. Based on this observation, we proposed an electrolyte-catalyst "two-phase reaction zone" model for the catalytic reduction of oxygen in carbon air electrode. According to this model, the best case for electrolyte-filling is that the air electrode is completely wetted while still remaining sufficient pores for fast diffusion of gaseous oxygen. it is shown that an electrolyte-flooded cell suffers low specific capacity and poor power performance due to slow diffusion of the dissolved oxygen in liquid electrolyte. Therefore, the status of electrolyte-filling plays an essential role in determining the specific capacity and power capability of a Li/O-2 cell. In addition, we found that at low discharge currents the Li/O-2 cell showed two discharge voltage plateaus. The second voltage plateau is attributed to a continuous discharge of Li/O-2 into Li2O, and this discharge shows high polarization due to the electrically isolating property of Li2O2. Published by Elsevier B.V. C1 [Zhang, Sheng S.; Foster, Donald; Read, Jeffrey] USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA. EM szhang@arl.army.mil RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 14 TC 219 Z9 223 U1 15 U2 185 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD FEB 15 PY 2010 VL 195 IS 4 SI SI BP 1235 EP 1240 DI 10.1016/j.jpowsour.2009.08.088 PG 6 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 519PK UT WOS:000271779100047 ER PT J AU Bansal, NP Zhu, DM AF Bansal, Narottam P. Zhu, Dongming TI Effects of doping on thermal conductivity of pyrochlore oxides for advanced thermal barrier coatings (vol 459, pg 192, 2007) SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Correction C1 [Bansal, Narottam P.] NASA, Glenn Res Ctr, Mat & Struct Div, Cleveland, OH 44135 USA. [Zhu, Dongming] NASA, Glenn Res Ctr, Vehicle Technol Directorate, US Army Res Lab, Cleveland, OH 44135 USA. RP Bansal, NP (reprint author), NASA, Glenn Res Ctr, Mat & Struct Div, 21000 Brookpk Rd,Mail Stop 106-5, Cleveland, OH 44135 USA. EM Narottam.P.Bansal@nasa.gov NR 1 TC 0 Z9 0 U1 1 U2 10 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD FEB 15 PY 2010 VL 527 IS 4-5 BP 1281 EP 1281 DI 10.1016/j.msea.2009.08.030 PG 1 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 548RM UT WOS:000273983900063 ER PT J AU Hu, SW Olulade, O Castillo, JG Santos, J Kim, S Tamer, GG Luh, WM Talavage, TM AF Hu, Shuowen Olulade, Olumide Castillo, Javier Gonzalez Santos, Joseph Kim, Sungeun Tamer, Gregory G., Jr. Luh, Wen-Ming Talavage, Thomas M. TI Modeling hemodynamic responses in auditory cortex at 1.5 T using variable duration imaging acoustic noise SO NEUROIMAGE LA English DT Article DE Imaging acoustic noise; Functional MRI; Hemodynamic response; Linear systems ID EVENT-RELATED FMRI; FUNCTIONAL MRI; SCANNER NOISE; BOLD RESPONSE; NONLINEARITY; INSULA; SYSTEM AB A confound for functional magnetic resonance imaging (fMRI), especially for auditory studies, is the presence of imaging acoustic noise generated mainly as a byproduct of rapid gradient switching during volume acquisition and, to a lesser extent, the radiofrequency transmit. This work utilized a novel pulse sequence to present actual imaging acoustic noise for characterization of the induced hemodynamic responses and assessment of linearity in the primary auditory cortex with respect to noise duration. Results show that responses to brief duration (46 ms) imaging acoustic noise is highly nonlinear while responses to longer duration (>1 s) imaging acoustic noise becomes approximately linear, with the right primary auditory cortex exhibiting a higher degree of nonlinearity than the left for the investigated noise durations. This study also assessed the spatial extent ofactivation induced by imaging acoustic noise, showing that the use of modeled responses (specific to imaging acoustic noise) as the reference waveform revealed additional activations in the auditory cortex not observed with a canonical gamma variate reference waveform, suggesting an improvement in detection sensitivity for imaging acoustic noise-induced activity. Longer duration (1.5 s) imaging acoustic noise was observed to induce activity that expanded outwards from Heschl's gyrus to cover the superior temporal gyrus as well as parts of the middle temporal gyrus and insula, potentially affecting higher level acoustic processing. Published by Elsevier Inc. C1 [Hu, Shuowen; Olulade, Olumide; Kim, Sungeun; Talavage, Thomas M.] Purdue Univ, Sch Elect & Comp Engn, W Lafayette, IN 47907 USA. [Hu, Shuowen] USA, Res Lab, Adelphi, MD USA. [Castillo, Javier Gonzalez; Santos, Joseph; Tamer, Gregory G., Jr.; Talavage, Thomas M.] Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA. [Luh, Wen-Ming] NIMH, NIH, Bethesda, MD 20892 USA. RP Hu, SW (reprint author), 465 NW Ave, W Lafayette, IN 47906 USA. EM hu@ecn.purdue.edu RI Gonzalez-Castillo, Javier/B-6903-2012; OI Gonzalez-Castillo, Javier/0000-0002-6520-5125 FU NIH [R01EB003990]; National Institute of Mental Health FX This research was supported in part by NIH grant R01EB003990 and the Intramural Research Program of the National Institute of Mental Health. NR 41 TC 9 Z9 9 U1 0 U2 3 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1053-8119 J9 NEUROIMAGE JI Neuroimage PD FEB 15 PY 2010 VL 49 IS 4 BP 3027 EP 3038 DI 10.1016/j.neuroimage.2009.11.051 PG 12 WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA 549OW UT WOS:000274064500015 PM 19948232 ER PT J AU Milner, E McCalmont, W Bhonsle, J Caridha, D Cobar, J Gardner, S Gerena, L Goodine, D Lanteri, C Melendez, V Roncal, N Sousa, J Wipf, P Dow, GS AF Milner, Erin McCalmont, William Bhonsle, Jayendra Caridha, Diana Cobar, Jose Gardner, Sean Gerena, Lucia Goodine, Duane Lanteri, Charlotte Melendez, Victor Roncal, Norma Sousa, Jason Wipf, Peter Dow, Geoffrey Stuart TI Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols SO MALARIA JOURNAL LA English DT Article ID BLOOD-BRAIN-BARRIER; MEFLOQUINE; PERMEABILITY; DRUGS; RESISTANCE; TRANSPORT; BILAYERS; CNS AB Background: The clinical utility for mefloquine has been eroded due to its association with adverse neurological effects. Better-tolerated alternatives are required. The objective of the present study was the identification of lead compounds that are as effective as mefloquine, but exhibit physiochemical properties likely to render them less susceptible to passage across the blood-brain barrier. Methods: A library of drug-like non-piperidine analogs of mefloquine was synthesized. These compounds are diverse in structure and physiochemical properties. They were screened in appropriate in vitro assays and evaluated in terms of their potential as lead compounds. The correlation of specific structural attributes and physiochemical properties with activity was assessed. Results: The most potent analogs were low molecular weight unconjugated secondary amines with no heteroatoms in their side-chains. However, these compounds were more metabolically labile and permeable than mefloquine. In terms of physiochemical properties, lower polar surface area, lower molecular weight, more freely rotatable bonds and fewer H-bond acceptors were associated with greater potency. There was no such relationship between activity and LogP, LogD or the number of hydrogen bond donors (HBDs). The addition of an H-bond donor to the side-chain yielded a series of active diamines, which were as metabolically stable as mefloquine but showed reduced permeability. Conclusions: A drug-like library of non-piperidine analogs of mefloquine was synthesized. From amongst this library an active lead series of less permeable, but metabolically stable, diamines was identified. C1 [Milner, Erin; McCalmont, William; Bhonsle, Jayendra; Caridha, Diana; Cobar, Jose; Gardner, Sean; Gerena, Lucia; Goodine, Duane; Lanteri, Charlotte; Melendez, Victor; Roncal, Norma; Sousa, Jason; Dow, Geoffrey Stuart] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. [Wipf, Peter] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA. RP Milner, E (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. EM erin.milner@amedd.army.mil RI Sousa, Jason/A-9177-2011 FU Absorption Systems (Exton PA) FX The MDCK permeability assays were performed under contract by Absorption Systems (Exton PA). The A2A and A1 screens were conducted by Caliper Biosciences (Hanover, MD). NR 22 TC 21 Z9 21 U1 0 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD FEB 11 PY 2010 VL 9 AR 51 DI 10.1186/1475-2875-9-51 PG 10 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 567RE UT WOS:000275463500005 PM 20149249 ER PT J AU Hu, SW Young, SS Hong, T Reynolds, JP Krapels, K Miller, B Thomas, J Nguyen, O AF Hu, Shuowen Young, S. Susan Hong, Tsai Reynolds, Joseph P. Krapels, Keith Miller, Brian Thomas, Jim Nguyen, Oanh TI Super-resolution for flash ladar imagery SO APPLIED OPTICS LA English DT Article AB Flash ladar systems are compact devices with high frame rates that hold promise for robotics applications, but these devices suffer from poor spatial resolution. This work develops a wavelet preprocessing stage to enhance registration of multiple frames and applies super-resolution to improve the resolution of flash ladar range imagery. The triangle orientation discrimination methodology was used for a subjective evaluation of the effectiveness of super-resolution for flash ladar. Results show statistically significant increases in the probability of target discrimination at all target ranges, as well as a reduction in subject response times for super-resolved imagery. (C) 2010 Optical Society of America C1 [Hu, Shuowen; Young, S. Susan] Army Res Lab, Adelphi, MD 20783 USA. [Hong, Tsai] Natl Inst Stand & Technol, Gaithersburg, MD 20899 USA. [Reynolds, Joseph P.; Krapels, Keith; Miller, Brian; Thomas, Jim; Nguyen, Oanh] Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Hu, SW (reprint author), Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM shuowen.hu@arl.army.mil NR 14 TC 9 Z9 9 U1 0 U2 4 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD FEB 10 PY 2010 VL 49 IS 5 BP 772 EP 780 DI 10.1364/AO.49.000772 PG 9 WC Optics SC Optics GA 554OK UT WOS:000274444100004 PM 20154743 ER PT J AU Barnoy, S Jeong, KI Helm, RF Suvarnapunya, AE Ranallo, RT Tzipori, S Venkatesan, MM AF Barnoy, S. Jeong, K. I. Helm, R. F. Suvarnapunya, A. E. Ranallo, R. T. Tzipori, S. Venkatesan, M. M. TI Characterization of WRSs2 and WRSs3, new second-generation virG(icsA)-based Shigella sonnei vaccine candidates with the potential for reduced reactogenicity SO VACCINE LA English DT Article DE Shigella sonnei; Live attenuated vaccine candidates; WRSs2; WRSs3 ID COLI-MSBB GENE; ENTEROINVASIVE ESCHERICHIA-COLI; CARRYING CLASS-2 INTEGRONS; FIELD GEL-ELECTROPHORESIS; LARGE VIRULENCE PLASMID; FLEXNERI 2A; ANTIMICROBIAL RESISTANCE; ORAL VACCINE; LIPID-A; MULTICOPY SUPPRESSOR AB Live, attenuated Shigella vaccine candidates, such as Shigella sonnei strain WRSS1, Shigella flexneri 2a strain SC602, and Shigella dysenteriae 1 strain WRSd1, are attenuated principally by the loss of the VirG(lcsA) protein. These candidates have proven to be safe and immunogenic in volunteer trials and in one study, efficacious against shigellosis. One drawback of these candidate vaccines has been the reactogenic symptoms of fever and diarrhea experienced by the volunteers, that increased in a dose-dependent manner. New, second-generation virG(icsA)-based S. sonnei vaccine candidates. WRSs2 and WRSs3, are expected to be less reactogenic while retaining the ability to generate protective levels of immunogenicity seen with WRSS1. Besides the loss of VirG(IcsA), WRSs2 and WRSs3 also lack plasmid-encoded enterotoxin ShET2-1 and its paralog ShET2-2. WRSs3 further lacks MsbB2 that reduces the endotoxicity of the lipid A portion of the bacterial LPS. Studies in cell cultures and in gnotobiotic piglets demonstrate that WRSs2 and WRSs3 have the potential to cause less diarrhea due to loss of ShET2-1 and ShET2-2 as well as alleviate febrile symptoms by loss of MsbB2. In guinea pigs, WRSs2 and WRSs3 were as safe, immunogenic and efficacious as WRSS1. Published by Elsevier Ltd. C1 [Barnoy, S.; Suvarnapunya, A. E.; Ranallo, R. T.; Venkatesan, M. M.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD USA. [Jeong, K. I.; Tzipori, S.] Tufts Univ, Div Infect Dis, Cummings Sch Vet Med, North Grafton, MA 01536 USA. [Helm, R. F.] Virginia Tech, Dept Biochem, Blacksburg, VA 24061 USA. RP Venkatesan, MM (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM malabi.venkatesan@us.army.mil OI Helm, Richard/0000-0001-5317-0925 FU NIAID Food and Waterborne Integrated Research Network (FWD IRN) [NO1-AI-30050] FX The authors would like to thank Dr. E.V. Oaks for S. sonnei LPS and Invaplex 50, Mr. Meng Shi for help with statistical analysis, Dr. Thomas Hale and COL Robert Bowden for reading the manuscript and providing encouragement and support. Studies involving the piglet model was supported by the NIAID Food and Waterborne Integrated Research Network (FWD IRN) award number NO1-AI-30050. NR 85 TC 16 Z9 17 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD FEB 10 PY 2010 VL 28 IS 6 BP 1642 EP 1654 DI 10.1016/j.vaccine.2009.11.001 PG 13 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 565NX UT WOS:000275301900030 PM 19932216 ER PT J AU Thera, MA Doumbo, OK Coulibaly, D Laurens, MB Kone, AK Guindo, AB Traore, K Sissoko, M Diallo, DA Diarra, I Kouriba, B Daou, M Dolo, A Baby, M Sissoko, MS Sagara, I Niangaly, A Traore, I Olotu, A Godeaux, O Leach, A Dubois, MC Ballou, WR Cohen, J Thompson, D Dube, T Soisson, L Diggs, CL Takala, SL Lyke, KE House, B Lanar, DE Dutta, S Heppner, DG Plowe, CV AF Thera, Mahamadou A. Doumbo, Ogobara K. Coulibaly, Drissa Laurens, Matthew B. Kone, Abdoulaye K. Guindo, Ando B. Traore, Karim Sissoko, Mady Diallo, Dapa A. Diarra, Issa Kouriba, Bourema Daou, Modibo Dolo, Amagana Baby, Mounirou Sissoko, Mahamadou S. Sagara, Issaka Niangaly, Amadou Traore, Idrissa Olotu, Ally Godeaux, Olivier Leach, Amanda Dubois, Marie-Claude Ballou, W. Ripley Cohen, Joe Thompson, Darby Dube, Tina Soisson, Lorraine Diggs, Carter L. Takala, Shannon L. Lyke, Kirsten E. House, Brent Lanar, David E. Dutta, Sheetij Heppner, D. Gray Plowe, Christopher V. TI Safety and Immunogenicity of an AMA1 Malaria Vaccine in Malian Children: Results of a Phase 1 Randomized Controlled Trial SO PLOS ONE LA English DT Article ID APICAL MEMBRANE ANTIGEN-1; PLASMODIUM-FALCIPARUM MALARIA; INSTITUTE-OF-RESEARCH; BLOOD-STAGE VACCINE; IMMUNE-RESPONSES; ANTIBODIES; CANDIDATE; INHIBIT; ADULTS; INVASION AB Background: The objective was to evaluate the safety and immunogenicity of the AMA1-based malaria vaccine FMP2.1/AS02(A) in children exposed to seasonal falciparum malaria. Methodology/Principal Findings: A Phase 1 double blind randomized controlled dose escalation trial was conducted in Bandiagara, Mali, West Africa, a rural town with intense seasonal transmission of Plasmodium falciparum malaria. The malaria vaccine FMP2.1/AS02(A) is a recombinant protein (FMP2.1) based on apical membrane antigen 1 (AMA1) from the 3D7 clone of P. falciparum, formulated in the Adjuvant System AS02(A). The comparator vaccine was a cell-culture rabies virus vaccine (RabAvert (R)). One hundred healthy Malian children aged 1-6 years were recruited into 3 cohorts and randomized to receive either 10 mu g FMP2.1 in 0.1 mL AS02(A), or 25 mu g FMP2.1 in 0.25 mL AS02(A), or 50 mu g FMP2.1 50 mg in 0.5 mL AS02(A), or rabies vaccine. Three doses of vaccine were given at 0, 1 and 2 months, and children were followed for 1 year. Solicited symptoms were assessed for 7 days and unsolicited symptoms for 30 days after each vaccination. Serious adverse events were assessed throughout the study. Transient local pain and swelling were common and more frequent in all malaria vaccine dosage groups than in the comparator group, but were acceptable to parents of participants. Levels of anti-AMA1 antibodies measured by ELISA increased significantly (at least 100-fold compared to baseline) in all 3 malaria vaccine groups, and remained high during the year of follow up. Conclusion/Significance: The FMP2.1/AS02(A) vaccine had a good safety profile, was well-tolerated, and induced high and sustained antibody levels in malaria-exposed children. This malaria vaccine is being evaluated in a Phase 2 efficacy trial in children at this site. C1 [Thera, Mahamadou A.; Doumbo, Ogobara K.; Coulibaly, Drissa; Kone, Abdoulaye K.; Guindo, Ando B.; Traore, Karim; Sissoko, Mady; Diallo, Dapa A.; Diarra, Issa; Kouriba, Bourema; Daou, Modibo; Dolo, Amagana; Baby, Mounirou; Sissoko, Mahamadou S.; Sagara, Issaka; Niangaly, Amadou; Traore, Idrissa] Univ Bamako, Malaria Res & Training Ctr, Bamako, Mali. [Laurens, Matthew B.; Takala, Shannon L.; Lyke, Kirsten E.; Plowe, Christopher V.] Univ Maryland, Sch Med, Howard Hughes Med Inst, Ctr Vaccine Dev, Baltimore, MD 21201 USA. [Olotu, Ally; Godeaux, Olivier; Leach, Amanda; Dubois, Marie-Claude; Ballou, W. Ripley; Cohen, Joe] GlaxoSmithKline Biol, Rixensart, Belgium. [Thompson, Darby; Dube, Tina] EMMES Corp, Rockville, MD USA. [Soisson, Lorraine; Diggs, Carter L.] US Agcy Int Dev, Malaria Vaccine Dev Program, Washington, DC 20523 USA. [House, Brent; Lanar, David E.; Dutta, Sheetij; Heppner, D. Gray] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. RP Thera, MA (reprint author), Univ Bamako, Malaria Res & Training Ctr, Bamako, Mali. EM cplowe@medicine.umaryland.edu RI Lanar, David/B-3560-2011; Laurens, Matthew/E-7293-2013 OI Laurens, Matthew/0000-0003-3874-581X FU National Institute of Allergy and Infectious Diseases (NIAID) [N01AI85346, U19AI065683]; Fogarty International Center, National Institutes of Health [D43TW001589]; United States Department of Defense [W81XWH-06-1-0427]; United States Agency for International Development (USAID); Doris Duke Charitable Foundation; Howard Hughes Medical Institute FX Site development and the conduct of the trial were supported by contract N01AI85346 and cooperative agreement U19AI065683 from the National Institute of Allergy and Infectious Diseases (NIAID), grant D43TW001589 from the Fogarty International Center, National Institutes of Health, and contract W81XWH-06-1-0427 from the United States Department of Defense and the United States Agency for International Development (USAID). Data management was provided by the EMMES Corporation through a contract with NIAID. Vaccine production and laboratory assays were supported by USAID, Washington, D. C. and by the Military Infectious Diseases Research Program, Fort Detrick, Maryland. Program staff from NIAID (the primary funder) contributed to study design discussions but played no role in the data collection and analysis, decision to publish, or preparation of the manuscript. Coauthors LS and CD from USAID (a secondary funder) contributed to both protocol design and manuscript preparation. CVP is supported by a Distinguished Clinical Scientist Award from the Doris Duke Charitable Foundation and by the Howard Hughes Medical Institute. NR 32 TC 27 Z9 29 U1 1 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 4 PY 2010 VL 5 IS 2 AR e9041 DI 10.1371/journal.pone.0009041 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 554ZB UT WOS:000274474400003 PM 20140214 ER PT J AU Peng, XQ Damarla, M Skirball, J Nonas, S Wang, XY Han, EJ Hasan, EJ Cao, X Boueiz, A Damico, R Tuder, RM Sciuto, AM Anderson, DR Garcia, JGN Kass, DA Hassoun, PM Zhang, JT AF Peng, Xin-qi Damarla, Mahendra Skirball, Jarrett Nonas, Stephanie Wang, Xiao-ying Han, Eugenia J. Hasan, Emile J. Cao, Xuan Boueiz, Adel Damico, Rachel Tuder, Rubin M. Sciuto, Alfred M. Anderson, Dana R. Garcia, Joe G. N. Kass, David A. Hassoun, Paul M. Zhang, Jun-tian TI Protective role of PI3-kinase/Akt/eNOS signaling in mechanical stress through inhibition of p38 mitogen-activated protein kinase in mouse lung SO ACTA PHARMACOLOGICA SINICA LA English DT Article DE mechanical stress; ventilator-associated lung injury; pulmonary capillary leakage; PI3K/Akt/eNOS; p38 MAPK signalings; signals cross-talk; pulmonary edema; wortmannin ID NITRIC-OXIDE SYNTHASE; VASCULAR-PERMEABILITY; ENDOTHELIAL-CELLS; XANTHINE OXIDOREDUCTASE; INDUCED APOPTOSIS; TRANSGENIC MICE; DOWN-REGULATION; NO PRODUCTION; INJURY; PHOSPHORYLATION AB Aim: To test the hypothesis that PI3K/Akt/eNOS signaling has a protective role in a murine model of ventilation associated lung injury (VALI) through down-regulation of p38 MAPK signaling. Methods: Male C57BL/J6 (wild-type, WT) or eNOS knockout mice (eNOS(-/-)) were exposed to mechanical ventilation (MV) with low (LVT, 7 mL/kg) and high tidal volume (HVT, 20 mL/kg) for 0-4 h. A subset of WT mice was administered the specific inhibitors of PI3K (100 nmol/L Wortmannin [Wort], ip) or of p38 MAPK (SB203580, 2 mg/kg, ip) 1 h before MV. Cultured type II alveolar epithelial cells C10 were exposed to 18% cyclic stretch for 2 h with or without 20 nmol/L Wort pretreatment. At the end of the experiment, the capillary leakage in vivo was assessed by extravasation of Evans blue dye (EBD), wet/dry weight ratio and lung lavage protein concentration. The lung tissue and cell lysate were also collected for protein and histological review. Results: MV decreased PI3K/Akt phosphorylation and eNOS expression but increased phospho-p38 MAPK expression along with a lung leakage of EBD. Inhibitions of phospho-Akt by Wort worsen the lung edema, whereas inhibition of p38 MAPK kinase restored activation of Akt together with alleviated capillary leakage. eNOS(-/-) mice showed an exacerbated lung edema and injury. The stretched C10 cells demonstrated that Wort diminished the activation of Akt, but potentiated phosphorylation of MAPK p38. Conclusion: Our results indicate that PI-3K/Akt/eNOS pathway has significant protective effects in VALI by preventing capillary leakage, and that there is a cross-talk between PI3K/Akt and p38 MAPK pathways in vascular barrier dysfunction resulting from VALI. C1 [Peng, Xin-qi; Sciuto, Alfred M.; Anderson, Dana R.] USA, Med Res Inst Chem Def, Div Analyt Toxicol, Aberdeen Proving Ground, MD 21010 USA. [Damarla, Mahendra; Skirball, Jarrett; Han, Eugenia J.; Hasan, Emile J.; Cao, Xuan; Boueiz, Adel; Damico, Rachel; Hassoun, Paul M.] Johns Hopkins Univ, Sch Med, Div Pulm & Crit Care Med, Baltimore, MD USA. [Kass, David A.] Johns Hopkins Univ, Sch Med, Dept Med, Div Cardiol, Baltimore, MD 21205 USA. [Tuder, Rubin M.] Univ Colorado, Sch Med, Dept Med, Div Pulm Sci & Crit Care Med, Denver, CO USA. [Nonas, Stephanie] Oregon Hlth & Sci Univ, Div Pulm & Crit Care Med, Portland, OR 97201 USA. [Garcia, Joe G. N.] Univ Chicago, Pritzker Sch Med, Dept Med, Chicago, IL 60637 USA. [Wang, Xiao-ying; Zhang, Jun-tian] Chinese Acad Med Sci, Inst Mat Med, Dept Pharmacol, Beijing 100050, Peoples R China. RP Peng, XQ (reprint author), USA, Med Res Inst Chem Def, Div Analyt Toxicol, Aberdeen Proving Ground, MD 21010 USA. EM xinqipeng@gmail.com; zhangjt@imm.ac.cn RI Garcia, Joe/E-8862-2010 FU American Heart Association [0765286U]; American Lung Association of Maryland; National Heart, Lung and Blood Institute [NIH R01 HL049441, P50 HL 73994] FX This work was supported by grants from American Heart Association (Mid-Atlantic, Beginning Grant-in-Aid #0765286U), American Lung Association of Maryland (Biomedical Research Grant, 2006) and the National Heart, Lung and Blood Institute (NIH R01 HL049441; P50 HL 73994). NR 38 TC 28 Z9 28 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1671-4083 J9 ACTA PHARMACOL SIN JI Acta Pharmacol. Sin. PD FEB PY 2010 VL 31 IS 2 BP 175 EP 183 DI 10.1038/aps.2009.190 PG 9 WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy SC Chemistry; Pharmacology & Pharmacy GA 556GO UT WOS:000274578400006 PM 20139900 ER PT J AU Gerard, BF AF Gerard, Brian F. TI Anisotropy and Voiding at High Strain Rates in a Mg Alloy Extrudate SO ADVANCED MATERIALS & PROCESSES LA English DT Article C1 [Gerard, Brian F.] Lehigh Univ, Bethlehem, PA 18015 USA. RP Gerard, BF (reprint author), USA, Picatinny Arsenal, NJ USA. EM brian.f.gerard@us.army.mil NR 0 TC 0 Z9 0 U1 1 U2 2 PU ASM INT PI MATERIALS PARK PA SUBSCRIPTIONS SPECIALIST CUSTOMER SERVICE, MATERIALS PARK, OH 44073-0002 USA SN 0882-7958 J9 ADV MATER PROCESS JI Adv. Mater. Process. PD FEB PY 2010 VL 168 IS 2 BP 16 EP 17 PG 2 WC Materials Science, Multidisciplinary SC Materials Science GA 559KO UT WOS:000274823800003 ER PT J AU Aksamija, A Yue, K Kim, H Grobler, F Krishnamurti, R AF Aksamija, Ajla Yue, Kui Kim, Hyunjoo Grobler, Francois Krishnamurti, Ramesh TI Integration of knowledge-based and generative systems for building characterization and prediction SO AI EDAM-ARTIFICIAL INTELLIGENCE FOR ENGINEERING DESIGN ANALYSIS AND MANUFACTURING LA English DT Article; Proceedings Paper CT 3rd International Conference on Design Computing and Cognition CY JUN 23-25, 2008 CL Georgia Inst Technol, Atlanta, GA HO Georgia Inst Technol DE Building Information Modeling; Knowledge-Based Model; Ontology; Shape Grammar ID SHAPE GRAMMARS; SIZAS HOUSES; MALAGUEIRA; LANGUAGE; BRAND AB This paper discusses the integration of knowledge bases and shape grammars for the generation of building models, covering interaction, system, and implementation. Knowledge-based and generative systems are combined to construct a method for characterizing existing buildings, in particular, their interior layouts based on exterior features and certain other parameters such as location and real dimensions. The knowledge-based model contains information about spatial use, organization, elements, and contextual information, with the shape grammar principally containing style rules. Buildings are analyzed and layouts are generated through communication and interaction between these two systems. The benefit of using an interactive system is that the complementary properties of the two schemes are employed to strengthen the overall process. Ontologies capture knowledge relating to architectural design principles, building anatomy. structure, and systems. Shape grammar rules embody change through geometric manipulation and transformation. Existing buildings are analyzed using this approach, and three-dimensional models are automatically generated. Two particular building types. the vernacular rowhouse and high-rise apartment building, both from Baltimore, Maryland, are presented to illustrate the process and for comparing the utilized methodologies. C1 [Grobler, Francois] USA, Corps Engineers Construct Engn Res Lab, Champaign, IL 61826 USA. [Aksamija, Ajla] Perkins Will, Tech Lab, Chicago, IL USA. [Yue, Kui; Krishnamurti, Ramesh] Carnegie Mellon Univ, Sch Architecture, Pittsburgh, PA 15213 USA. [Kim, Hyunjoo] Calif State Univ Fullerton, Dept Civil & Environm Engn, Fullerton, CA 92634 USA. RP Grobler, F (reprint author), USA, Corps Engineers Construct Engn Res Lab, POB 9005, Champaign, IL 61826 USA. EM Francois.Grobler@erdc.usace.army.mi NR 20 TC 2 Z9 2 U1 1 U2 5 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0890-0604 J9 AI EDAM JI AI EDAM-Artif. Intell. Eng. Des. Anal. Manuf. PD FEB PY 2010 VL 24 IS 1 BP 3 EP 16 DI 10.1017/S0890060409990138 PG 14 WC Computer Science, Artificial Intelligence; Computer Science, Interdisciplinary Applications; Engineering, Multidisciplinary; Engineering, Manufacturing SC Computer Science; Engineering GA 553NW UT WOS:000274375100002 ER PT J AU Tovanabutra, S Sanders, EJ Graham, SM Mwangome, M Peshu, N McClelland, RS Muhaari, A Crossler, J Price, MA Gilmour, J Michael, NL McCutchan, FM AF Tovanabutra, Sodsai Sanders, Eduard J. Graham, Susan M. Mwangome, Mary Peshu, Norbert McClelland, R. Scott Muhaari, Allan Crossler, Jacqueline Price, Matt A. Gilmour, Jill Michael, Nelson L. McCutchan, Francine M. TI Evaluation of HIV Type 1 Strains in Men Having Sex with Men and in Female Sex Workers in Mombasa, Kenya SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID CIRCULATING RECOMBINANT FORM; MOLECULAR EPIDEMIOLOGY; GENETIC DIVERSITY; ENVELOPE GLYCOPROTEIN; WESTERN KENYA; RISK-FACTORS; DRUG-USERS; SUBTYPE-B; PREVALENCE; INFECTION AB We compared HIV-1 strains in incident and prevalent infections in a cohort of men having sex with men (MSM) and female sex workers (FSW) near Mombasa, Kenya and conducted a cross-sectional study of viral isolates from a sample of HIV-1-infected MSM and FSW in Kilifi, Coast Province, Kenya. RNA extracted from plasma of 13 MSM, 9 FSW, and one heterosexual male was amplified by nested RT-PCR and the products were directly sequenced. HIV-1 strains from 21 individuals were characterized with one or more complete genome sequences, and two were sequenced in the Nef gene. The envelope quasispecies was also studied in one individual. Among MSM, eight strains were subtype A and five were recombinant. There were two epidemiologically linked pairs of sequences; one pair was subtype A and the other pair was a complex AA2CD recombinant of identical structure. Another MSM was dually infected with DG recombinant strains of related, but nonidentical, structure. MSM also harbored AC and AD recombinant strains. The FSW harbored seven subtype A strains, an AD recombinant, and an AA2D strain related to CRF16_A2D. The one heterosexual male studied had a subtype A infection. This MSM epidemic in Kenya appears to be of local origin, harboring many strains typical of the broader Kenyan epidemic. Characteristics of a close social network were identified, with extended chains of transmission, novel recombinant strains possibly generated within the network, and a relatively high proportion of recombinant and dual infections. C1 [Tovanabutra, Sodsai] US Mil HIV Res Program, Henry M Jackson Fdn, Walter Reed Army Inst Res, Rockville, MD 20850 USA. [Sanders, Eduard J.; Graham, Susan M.; Mwangome, Mary; Peshu, Norbert; Muhaari, Allan] Kenya Govt Med Res Ctr, Ctr Geog Med Res Coast, Kilifi, Kenya. [Sanders, Eduard J.] Univ Oxford, Ctr Clin Vaccinol & Trop Med, Headington, England. [Graham, Susan M.; McClelland, R. Scott] Univ Washington, Seattle, WA 98109 USA. [Price, Matt A.; Gilmour, Jill] Int AIDS Vaccine Initiat, New York, NY 10038 USA. RP Tovanabutra, S (reprint author), US Mil HIV Res Program, Henry M Jackson Fdn, Walter Reed Army Inst Res, 1600 E Gude Dr, Rockville, MD 20850 USA. EM stovanabutra@hivresearch.org OI Graham, Susan/0000-0001-7847-8686 FU International AIDS Vaccine Initiative (IAVI) FX We are grateful to the subjects for their participation in the study. We thank the clinic staff of the KEMRI-clinic in Mtwapa, the laboratory staff at the KEMRI-Wellcome Trust Research laboratories in Kilifi, Meera Bose for technical assistance, and Eric Sanders-Buell for his advice on HIV-1 cloning and sequencing. The study was supported by the International AIDS Vaccine Initiative (IAVI). The opinions or assertions contained herein are the private views of the authors, and are not to be construed as official, or as reflecting true views of the Department of the Army or the Department of Defense, the Kenya Medical Research Institute, or IAVI. This article was published with permission from the Director of KEMRI. NR 39 TC 20 Z9 20 U1 0 U2 4 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD FEB PY 2010 VL 26 IS 2 BP 123 EP 131 DI 10.1089/aid.2009.0115 PG 9 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 555PZ UT WOS:000274526900001 PM 20156095 ER PT J AU Moawad, FJ Maydonovitch, CL Lake, JM Veerappan, GR AF Moawad, Fouad J. Maydonovitch, Corinne L. Lake, Jason M. Veerappan, Ganesh R. TI PPIs May Not Predispose to Eosinophilic Esophagitis SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Letter C1 [Moawad, Fouad J.; Maydonovitch, Corinne L.; Lake, Jason M.; Veerappan, Ganesh R.] Walter Reed Army Med Ctr, Dept Med, Gastroenterol Serv, Washington, DC 20307 USA. RP Moawad, FJ (reprint author), Walter Reed Army Med Ctr, Dept Med, Gastroenterol Serv, 6900 Georgia Ave, Washington, DC 20307 USA. EM Fouad.Moawad@amedd.army.mil NR 5 TC 3 Z9 3 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD FEB PY 2010 VL 105 IS 2 BP 468 EP 469 DI 10.1038/ajg.2009.617 PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 554RP UT WOS:000274452400031 PM 20139878 ER PT J AU Perez, F Hujer, AM Hulten, EA Fishbain, J Hujer, KM Aron, D Thweatt, K Donskey, CJ Bonomo, RA AF Perez, Federico Hujer, Andrea M. Hulten, Edward A. Fishbain, Joel Hujer, Kristine M. Aron, David Thweatt, Katherine Donskey, Curtis J. Bonomo, Robert A. TI Antibiotic resistance determinants in Acinetobacter spp and clinical outcomes in patients from a major military treatment facility SO AMERICAN JOURNAL OF INFECTION CONTROL LA English DT Article ID BAUMANNII; INFECTION; BACTEREMIA; MORTALITY; IMPACT AB We explored the association of antibiotic-resistant phenotypes and genotypes in Acinetobacter spp with clinical outcomes and characteristics in 75 patients from a major military treatment facility. Amikacin resistance was associated with nosocomial acquisition of A baumannii, and carbapenem resistance and bla(OXA-23) were associated with the need for mechanical ventilation. The presence of bla(OXA-23) also correlated with longer hospital and ICU stay. Associations between bla(OXA-23) and complexity, duration, and changes made to antibiotic regimens also existed. Copyright (C) 2010 by Elsevier Inc on behalf of the Association for Professionals in Infection Control and Epidemiology, Inc. (Am J Infect Control 2010; 38: 63-5.) C1 [Bonomo, Robert A.] Louis Stokes Cleveland Dept Vet Affairs Med Ctr, Infect Dis Sect, Res Serv, Cleveland, OH 44106 USA. [Perez, Federico] Univ Hosp Case Med Ctr, Div Infect Dis & HIV Med, Cleveland, OH USA. [Hulten, Edward A.; Fishbain, Joel] Walter Reed Army Med Ctr, Dept Internal Med, Washington, DC 20307 USA. [Bonomo, Robert A.] Case Western Reserve Univ, Sch Med, Dept Mol Biol & Pharmacol, Cleveland, OH USA. [Bonomo, Robert A.] Case Western Reserve Univ, Sch Med, Dept Microbiol, Cleveland, OH USA. RP Bonomo, RA (reprint author), Louis Stokes Cleveland Dept Vet Affairs Med Ctr, Infect Dis Sect, Res Serv, 10701 East Blvd, Cleveland, OH 44106 USA. EM robert.bonomo@med.va.gov FU Veterans Affairs Merit Review Program; VISN 10 Geriatric Research Education and Clinical Center; National Institutes of Health [RO1 AI072219]; Wyeth Pharmaceuticals; Veterans Affairs Merit Review FX Supported by the Veterans Affairs Merit Review Program, VISN 10 Geriatric Research Education and Clinical Center, and the National Institutes of Health (RO1 AI072219; to R. A. B.); by a fellowship sponsored by Wyeth Pharmaceuticals ( to F. P.); and by the Veterans Affairs Merit Review Program ( to C.J.D.). NR 9 TC 15 Z9 15 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-6553 J9 AM J INFECT CONTROL JI Am. J. Infect. Control PD FEB PY 2010 VL 38 IS 1 BP 63 EP 65 DI 10.1016/j.ajic.2009.05.007 PG 3 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 559WQ UT WOS:000274859400012 PM 19783325 ER PT J AU Stany, MP Maxwell, GL Rose, GS AF Stany, Michael P. Maxwell, G. Larry Rose, G. Scott TI Clinical Decision Making Using Ovarian Cancer Risk Assessment SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Review DE CA-125 level; ovarian cancer; risk assessment; screening ID ORAL-CONTRACEPTIVE USE; ADNEXAL MASSES; POSTMENOPAUSAL WOMEN; PREOPERATIVE DIAGNOSIS; BREAST-CANCER; TUMORS; BRCA1; MALIGNANCY; MUTATIONS; CA-125 AB OBJECTIVE. Although any adnexal abnormality found at imaging can be concerning for an ovarian malignancy, the clinician must perform an evaluation to decide if the actual likelihood of malignancy justifies the risk of surgery. When determining the likelihood of an asympto-matic, incidental adnexal mass being malignant, the provider must answer one important question: Do the clinical findings warrant the potential morbidity of surgery? This article will focus on the decision making that goes into such an evaluation. CONCLUSION. A patient's medical history, physical examination, CA-125 level, and imaging characteristics are all factors that impact the ultimate decision of whether a patient can be observed with repeat imaging or should proceed to surgical evaluation. C1 [Stany, Michael P.; Maxwell, G. Larry; Rose, G. Scott] Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Washington, DC 20307 USA. RP Rose, GS (reprint author), Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, 6900 Georgia Ave NW,Bldg 2,Rm 2106, Washington, DC 20307 USA. EM gaylord.rose@amedd.army.mil NR 44 TC 4 Z9 4 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD FEB PY 2010 VL 194 IS 2 BP 337 EP 342 DI 10.2214/AJR.09.3669 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 548HU UT WOS:000273951900010 PM 20093593 ER PT J AU Grant, RJ Baldwin, CD Nalca, A Zoll, S Blyn, LB Eshoo, MW Matthews, H Sampath, R Whitehouse, CA AF Grant, Rebecca J. Baldwin, Carson D. Nalca, Aysegul Zoll, Scott Blyn, Lawrence B. Eshoo, Mark W. Matthews, Heather Sampath, Rangarajan Whitehouse, Chris A. TI Application of the Ibis-T5000 Pan-Orthopoxvirus Assay to Quantitatively Detect Monkeypox Viral Loads in Clinical Specimens from Macaques Experimentally Infected with Aerosolized Monkeypox Virus SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID MASS-SPECTROMETRY; RAPID IDENTIFICATION; ROCHE LIGHTCYCLER; SMALLPOX; PCR; CONGO; DIFFERENTIATION; SURVEILLANCE; PATHOGENS; EFFICACY AB Monkeypox Virus (MPXV), a member of the family Poxviridae and genus Orthopoxvirus. causes a smallpox-like disease in humans. A previously described pan-Orthopoxvirus assay, based on a broad-range polymerase chain reaction (PCR) coupled with electrospray ionization mass spectrometry (PCR/ESI-MS), was evaluated for its ability to detect MPXV front spiked human and aerosol-infected cynomolgous macaque (Macaca fascicularis) samples. Detection of MPXV DNA from macaque tissue. blood, and spiked human blood by the PCR/ESI-MS pan-Orthopoxvirus assay was comparable, albeit at slightly higher levels, to the Current gold standard method of real-time PCR with the pan-Orthopoxvirus assay and had a limit of detection of 200 plaque-forming units. Furthermore, the platform was able to distinguish MPXV and vaccinia Viruses that were spiked into macaque blood samples at various concentrations. This platform provides a new tool for the diagnosis and monitoring of orthopoxviral loads during vaccine or antiviral Studies, but also could provide rapid identification during natural Outbreaks or bioterrorism attacks. C1 [Grant, Rebecca J.] USA, Med Res Inst Infect Dis, Div Sci & Technol, Ft Detrick, MD 21702 USA. [Blyn, Lawrence B.; Eshoo, Mark W.; Matthews, Heather; Sampath, Rangarajan] Ibis Biosci, Carlsbad, CA USA. RP Grant, RJ (reprint author), USA, Med Res Inst Infect Dis, Div Sci & Technol, 1301 Ditto Ave,Room 123, Ft Detrick, MD 21702 USA. EM rebecca.j.grant@amedd.army.mil FU Defense Advanced Research Projects Agency; Department of Homeland Security [W81XWH-05-C-0116]; U.S. Defense Threat Reduction Agency [114538]; Office of Biodefense Research Affairs National Institute of Allergy and Infectious Diseases [A120-B11]; U.S. Army Medical Research Institute of Infectious Diseases FX This study was Supported by the Defense Advanced Research Projects Agency, the Department of Homeland Security (contract no, W81XWH-05-C-0116), the U.S. Defense Threat Reduction Agency (U.S. Army Medical Research Institute of Infectious Diseases Research Plan #114538), and the Office of Biodefense Research Affairs National Institute of Allergy and Infectious Diseases (interagency agreement A120-B11). This research was performed while Rebecca J. Grant held a National Research Council Research Associateship Award at the U.S. Army Medical Research Institute of Infectious Diseases. NR 25 TC 5 Z9 5 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 2010 VL 82 IS 2 BP 318 EP 323 DI 10.4269/ajtmh.2010.09-0361 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 552CC UT WOS:000274263300024 PM 20134011 ER PT J AU Capeding, RZ Brion, JD Caponpon, MM Gibbons, RV Jarman, RG Yoon, IK Libraty, DH AF Capeding, Rosario Z. Brion, Job D. Caponpon, Mercydina M. Gibbons, Robert V. Jarman, Richard G. Yoon, In-Kyu Libraty, Daniel H. TI The Incidence, Characteristics, and Presentation of Dengue Virus Infections during Infancy SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID HEMORRHAGIC-FEVER; THAILAND; PATHOGENESIS; SEVERITY; ANTIBODY; CHILDREN; BANGKOK; DISEASE AB Infants are a vulnerable and unique Population at risk for dengue in endemic areas. This report describes the incidence and presenting clinical features of infant dengue virus (DENV) infections from a prospective community-based study performed between January 2007 and May 2009 in the Philippines. DENV3 was the predominant infecting serotype over a wide spectrum of disease severity ranging from inapparent infection to dengue hemorrhagic fever (DHF). In 2007, the incidence of inapparent DENV infections during infancy was 103 per 1,000 persons person-years and 6-fold higher than symptomatic dengue. The age-specific incidence of infant DHF was 0.5 per 1,000 persons over the age of 3-8 months, and it disappeared by age 9 months. A febrile seizure, macular rash, petechiae, and lower platelet count were presenting clinical features associated with DENV infection among infants with acute undifferentiated febrile illnesses, Community-based studies can help to delineate the incidence rates, disease spectrum, and clinical features of DENV infections during infancy. C1 [Libraty, Daniel H.] Univ Massachusetts, Med Ctr, Ctr Infect Dis & Vaccinec Res, Sch Med, Worcester, MA 01655 USA. [Brion, Job D.; Caponpon, Mercydina M.] San Pablo City Hlth Off, San Pablo, Laguna, Philippines. Res Inst Trop Med, Dept Microbiol, Manila, Philippines. Res Inst Trop Med, Dept Med, Manila, Philippines. [Gibbons, Robert V.; Jarman, Richard G.; Yoon, In-Kyu] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Capeding, Rosario Z.] Res Inst Trop Med, Dept Microbiol, Muntinlupa, Metro Manila, Philippines. [Capeding, Rosario Z.] Res Inst Trop Med, Dept Med, Muntinlupa, Metro Manila, Philippines. RP Libraty, DH (reprint author), Univ Massachusetts, Med Ctr, Ctr Infect Dis & Vaccinec Res, Sch Med, 55 Lake Ave N, Worcester, MA 01655 USA. EM lerosecap@yahoo.com.ph; jdbrion@yahoo.com; drdinamendoza@yahoo.com; robert.gibbons@afrims.org; richard.jarman@afrims.org; InKyu.Yoon@afrims.org; daniel.libraty@umassmed.edu FU National Institutes of Health [U01 AI065654] FX The study was supported by National Institutes of Health Grant U01 AI065654. The contents of this publication are solely the responsibility of the authors and do not necessarily reflect the official views of the National Institutes of Health or the U.S. Department of Defense. NR 25 TC 24 Z9 25 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 2010 VL 82 IS 2 BP 330 EP 336 DI 10.4269/ajtmh.2010.09-0542 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 552CC UT WOS:000274263300026 PM 20134013 ER PT J AU Rice, RD Parker, DM Seery, JM Arciero, CA AF Rice, Robert D. Parker, David M. Seery, Jason M. Arciero, Cletus A. TI A Small Bowel Obstruction Secondary to a Meckel's Enterolith SO AMERICAN SURGEON LA English DT Letter C1 [Rice, Robert D.] Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, Ft Gordon, GA 30905 USA. RP Rice, RD (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, Ft Gordon, GA 30905 USA. EM Robert.D.Rice@amedd.army.mil NR 6 TC 2 Z9 2 U1 0 U2 0 PU SOUTHEASTERN SURGICAL CONGRESS PI ATLANTA PA 141 WEST WIEUCA RD, STE B100, ATLANTA, GA 30342 USA SN 0003-1348 J9 AM SURGEON JI Am. Surg. PD FEB PY 2010 VL 76 IS 2 BP 222 EP 224 PG 3 WC Surgery SC Surgery GA 556TV UT WOS:000274616400023 PM 20336908 ER PT J AU Seery, JM Reyes, AM Rice, RD Dodge, AN Armstrong, PJ AF Seery, Jason M. Reyes, Angel M. Rice, Robert D. Dodge, Angela N. Armstrong, Peter J. TI Primary Venous Aneurysms: Two Case Reports SO AMERICAN SURGEON LA English DT Letter C1 [Seery, Jason M.] Dwight D Eisenhower Army Med Ctr, Attn Gen Surg Clin, Ft Gordon, GA 30905 USA. RP Seery, JM (reprint author), Dwight D Eisenhower Army Med Ctr, Attn Gen Surg Clin, 300 Hosp Rd, Ft Gordon, GA 30905 USA. EM jason.m.seery@amedd.army.mil NR 5 TC 1 Z9 1 U1 0 U2 1 PU SOUTHEASTERN SURGICAL CONGRESS PI ATLANTA PA 141 WEST WIEUCA RD, STE B100, ATLANTA, GA 30342 USA SN 0003-1348 J9 AM SURGEON JI Am. Surg. PD FEB PY 2010 VL 76 IS 2 BP 224 EP 225 PG 2 WC Surgery SC Surgery GA 556TV UT WOS:000274616400024 PM 20336909 ER PT J AU Bevilacqua, VLH Nilles, JM Rice, JS Connell, TR Schenning, AM Reilly, LM Durst, HD AF Bevilacqua, Vicky L. H. Nilles, J. Michael Rice, Jeffrey S. Connell, Theresa R. Schenning, Amanda M. Reilly, Lisa M. Durst, H. Dupont TI Ricin Activity Assay by Direct Analysis in Real Time Mass Spectrometry Release Detection of Adenine Release SO ANALYTICAL CHEMISTRY LA English DT Article ID RIBOSOME-INACTIVATING PROTEINS; N-GLYCOSIDASE ACTIVITY; A-CHAIN; EUKARYOTIC RIBOSOMES; RNA AB Biotoxin activity assays typically involve multistep sample preparation, multicomponent reactions, multistep analysis, or a combination thereof. We report a single-step, real-time ricin activity assay that requires little or no sample preparation and employs direct analysis in real time mass spectrometry. The release of adenine from the inhomogeneous substrate herring sperm DNA by ricin was determined to be 53 +/- 2 pmol adenine per picomole of ricin per hour. This procedure can be readily adapted to any enzyme for which a reactant or product of low molecular weight (up to similar to 600) can be identified. C1 [Bevilacqua, Vicky L. H.; Rice, Jeffrey S.; Reilly, Lisa M.; Durst, H. Dupont] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Nilles, J. Michael; Connell, Theresa R.; Schenning, Amanda M.] SAIC, Gunpowder Branch, Gunpowder, MD 21010 USA. RP Bevilacqua, VLH (reprint author), USA, Edgewood Chem Biol Ctr, 5183 Black Hawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM Vicky.bevilacqua@us.army.mil FU Defense Threat Reduction Agency [0602384BP] FX We thank Drs. James A. Laramee and Rabih Jabbour for manuscript review, Dr. Steven R. Channel and Mr. Alan Zulich for administrative support, and the Defense Threat Reduction Agency for funding (Grant Program Element 0602384BP). NR 14 TC 24 Z9 24 U1 1 U2 18 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD FEB 1 PY 2010 VL 82 IS 3 BP 798 EP 800 DI 10.1021/ac9025972 PG 3 WC Chemistry, Analytical SC Chemistry GA 548RK UT WOS:000273983700009 PM 20055481 ER PT J AU Bleckner, LL Bina, S Kwon, KH McKnight, G Dragovich, A Buckenmaier, CC AF Bleckner, Lisa L. Bina, Saiid Kwon, Kyung H. McKnight, Geselle Dragovich, Anthony Buckenmaier, Chester C., III TI Serum Ropivacaine Concentrations and Systemic Local Anesthetic Toxicity in Trauma Patients Receiving Long-Term Continuous Peripheral Nerve Block Catheters SO ANESTHESIA AND ANALGESIA LA English DT Article ID PLASMA-PROTEIN BINDING; EPIDURAL INFUSION; SCIATIC BLOCK; PHARMACOKINETICS; BUPIVACAINE; CONVULSIONS; ANALGESIA; EFFICACY AB BACKGROUND: Ropivacaine is a long-acting local anesthetic used frequently for peripheral nerve blocks and continuous peripheral nerve block catheters. Combat trauma patients at Walter Reed Army Medical Center often receive continuous peripheral nerve block catheters as part of their pain regimen. These catheters remain in situ for several days to weeks. In this study, we evaluated the free ropivacaine drug levels over time in trauma patients by measuring the serum concentration of bound and unbound local anesthetic. The corresponding alpha(1)-acid glycoprotein concentration in patients with prolonged ropivacaine infusions was also measured. METHODS: Fifteen patients were enrolled in the study; 2 patients were excluded because only a single ropivacaine level was obtained. Of the remaining 13 patients in the study, 2 had peripheral nerve catheters placed at the time of enrollment; the remaining 11 patients had catheters placed before enrollment. These patients were already receiving 0.2% ropivacaine infusions for a period of 18-126 h before the first assessment of local anesthetic level. Catheters infused 0.2% ropivacaine at a rate of 6-14 mL/h; catheter boluses were administered with 0.5% ropivacaine. Local anesthetic blood concentrations were scheduled to be measured on Days 1, 3, 5, 7, and 10 and every 3 days thereafter until all catheters were removed, although not all patients underwent each assessment. Specimens were assayed using high-performance liquid chromatography for total and free serum ropivacaine concentrations. alpha(1)-Acid glycoprotein was also measured. RESULTS: Thirteen patients remained in the study, for a total of 59 blood samples. The median number of days catheters remained in situ for the duration of acute pain therapy was 7 days (range: 6-27 days). The median number of days catheters remained in situ after enrollment into the study was 7 days (range: 4-25 days). The median number of blood samples collected per patient was 4 (range: 2-10 samples). Two patients had isolated increased concentrations of free ropivacaine into a previously identified toxic range with no obvious mitigating factors; both patients had received a 300-mg bolus of 0.5% ropivacaine approximately 24 h before that blood collection. The median ropivacaine concentration over the length of the study was 0.11 mg/L (range: undetectable to 0.63 mg/L). During the first week of the study, the median change in ropivacaine concentration per patient was 0.00 mg/L (range: -0.35 to 0.47 mg/L). CONCLUSION: Although 2 patients demonstrated isolated serum ropivacaine concentration spikes into a previously identified toxic range, continuous peripheral nerve block catheter management and local anesthetic doses as practiced at Walter Reed Army Medical Center did not result in clinically evident systemic ropivacaine toxicity. There was no correlation between free ropivacaine concentration and alpha(1)-acid glycoprotein concentration except in patients who had already been receiving ropivacaine infusions before entering the study. Despite this lack of correlation, the total duration of local anesthetic infusion did not seem to influence the free concentration of the drug. (Anesth Analg 2010;110:630-4) C1 [Bleckner, Lisa L.; Kwon, Kyung H.; McKnight, Geselle; Buckenmaier, Chester C., III] Walter Reed Army Med Ctr, Dept Surg Anesthesia & Operat Serv, Washington, DC 20307 USA. [Bleckner, Lisa L.; Bina, Saiid; Dragovich, Anthony; Buckenmaier, Chester C., III] Uniformed Serv Univ Hlth Sci, Dept Anesthesiol, Bethesda, MD 20814 USA. RP Bleckner, LL (reprint author), 7301 Maple Ave, Chevy Chase, MD 20815 USA. EM lbleckner@yahoo.com FU John P. Murtha Neuroscience and Pain Institute; Henry M. Jackson Foundation; departmental funds FX Supported by John P. Murtha Neuroscience and Pain Institute, Henry M. Jackson Foundation, and departmental funds. NR 17 TC 19 Z9 19 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD FEB PY 2010 VL 110 IS 2 BP 630 EP 634 DI 10.1213/ANE.0b013e3181c76a33 PG 5 WC Anesthesiology SC Anesthesiology GA 547XC UT WOS:000273922100060 PM 19955504 ER PT J AU La Shell, MS Otto, HF Whisman, BA Waibel, KH White, AA Calabria, CW AF La Shell, Mark S. Otto, Hans F. Whisman, Bonnie A. Waibel, Kirk H. White, Andrew A. Calabria, Christopher W. TI ALLERGY TO PUMPKIN AND CROSS-REACTIVITY TO POLLENS AND OTHER FOODS SO ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY LA English DT Letter C1 [La Shell, Mark S.] David Grant Med Ctr, Travis AFB, CA USA. [Otto, Hans F.; Whisman, Bonnie A.; Calabria, Christopher W.] Wilford Hall USAF Med Ctr, San Antonio, TX USA. [Waibel, Kirk H.] Brooke Army Med Ctr, San Antonio, TX USA. [White, Andrew A.] Scripps Clin, La Jolla, CA 92037 USA. RP La Shell, MS (reprint author), David Grant Med Ctr, Travis AFB, CA USA. EM marklashell@gmail.com NR 6 TC 1 Z9 1 U1 1 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1081-1206 J9 ANN ALLERG ASTHMA IM JI Ann. Allergy Asthma Immunol. PD FEB PY 2010 VL 104 IS 2 BP 178 EP 180 DI 10.1016/j.anai.2009.11.048 PG 3 WC Allergy; Immunology SC Allergy; Immunology GA 701OF UT WOS:000285828400012 PM 20306822 ER PT J AU Carpenter, KM Fowler, JM Maxwell, GL Andersen, BL AF Carpenter, Kristen M. Fowler, Jeffrey M. Maxwell, G. Larry Andersen, Barbara L. TI Direct and Buffering Effects of Social Support Among Gynecologic Cancer Survivors SO ANNALS OF BEHAVIORAL MEDICINE LA English DT Article DE Gynecologic cancer; Cancer survivorship; Social support; Traumatic stress; Depressive symptoms ID QUALITY-OF-LIFE; EARLY-STAGE BREAST; POSTTRAUMATIC-STRESS-DISORDER; PERSONAL COPING RESOURCES; DEPRESSIVE SYMPTOMS; ONCOLOGY-GROUP; PSYCHOLOGICAL DISTRESS; ADJUVANT CHEMOTHERAPY; FUNCTIONAL ASSESSMENT; CERVICAL-CANCER AB There are few studies of QoL among long-term gynecologic cancer survivors; available data suggest significant sequelae of disease and treatment. Research clarifying circumstances that improve difficult survivorship trajectories is lacking. The present study examines whether social support moderates the relationship between physical functioning and psychological outcomes by testing the stress-buffering hypothesis. Participants (N = 260) were gynecologic cancer survivors (cervical, n = 47; endometrial, n = 133; ovarian, n = 69; vulvar, n = 11). Compromised physical health was conceptualized as multidimensional. Social support (SNI, PSS-Fa, PSS-Fr, ISEL) was tested as a buffer of adverse psychological outcomes (IES-R, CES-D). Results for traumatic stress provided evidence for buffering; whereas social support was of general benefit for depressive symptoms. Effects varied by source and type of support. These results suggest that circumstances for gynecologic cancer survivors burdened with physical symptoms may be worse for those with fewer support resources, providing needed insight into a common target of psychosocial interventions for cancer survivors. C1 [Carpenter, Kristen M.; Andersen, Barbara L.] Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA. [Fowler, Jeffrey M.; Andersen, Barbara L.] Ohio State Univ, Med Ctr, Ctr Comprehens Canc, Columbus, OH 43210 USA. [Maxwell, G. Larry] Walter Reed Army Med Ctr, Gynecol Dis Ctr, Washington, DC 20307 USA. [Maxwell, G. Larry] Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA. RP Carpenter, KM (reprint author), Ohio State Univ, Dept Psychol, 1835 Neil Ave,159 Psychol Bldg, Columbus, OH 43210 USA. EM carpenter.292@osu.edu RI Carpenter, Kristen/I-1569-2013 FU NCI NIH HHS [L30 CA136257, R01 CA092704, K05CA098133, R01CA92704, K05 CA098133]; NCRR NIH HHS [UL1 RR025755] NR 83 TC 35 Z9 36 U1 4 U2 19 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0883-6612 J9 ANN BEHAV MED JI Ann. Behav. Med. PD FEB PY 2010 VL 39 IS 1 BP 79 EP 90 DI 10.1007/s12160-010-9160-1 PG 12 WC Psychology, Multidisciplinary SC Psychology GA 587SQ UT WOS:000277013400009 PM 20151235 ER PT J AU Nissan, A Protic, M Bilchik, A Eberhardt, J Peoples, GE Stojadinovic, A AF Nissan, Aviram Protic, Mladjan Bilchik, Anton Eberhardt, John Peoples, George E. Stojadinovic, Alexander TI Predictive Model of Outcome of Targeted Nodal Assessment in Colorectal Cancer SO ANNALS OF SURGERY LA English DT Article ID PROSPECTIVE MULTICENTER TRIAL; RESECTABLE COLON-CANCER; EARLY-STAGE MELANOMA; SENTINEL NODE; BREAST-CANCER; LYMPH-NODES; CARCINOMA; BIOPSY; VIVO; VALIDATION AB Background: Improvement in staging accuracy is the principal aim of targeted nodal assessment in colorectal carcinoma. Technical factors independently predictive of false negative (FN) sentinel lymph node (SUN) mapping should be identified to facilitate operative decision making. Purpose: To define independent predictors of FN SLN mapping and to develop a predictive model that Could support surgical decisions. Patients and Methods: Data was analyzed from 2 completed prospective clinical trials involving 278 patients with colorectal carcinoma undergoing SLN mapping. Clinical outcome of interest was FN SLN(s),defined as one (s) with no apparent tumor cells in the presence of non-SLN metastases. To assess the independent predictive effect of a covariate for a nominal response (FN SLN), a logistic regression model was constructed and parameters estimated using maximum likelihood. A probabilistic Bayesian model was also trained and cross validated using 10-fold train-and-test sets to predict FN SLN mapping. Area under the curve (AUC) from receiver operating characteristics Curves of these predictions was calculated to determine the predictive value of the model. Results: Number of SLNs (<3; P = 0.03) and tumor-replaced nodes (P < 0.01) independently predicted FN SLN. Cross validation of the model created with Bayesian Network Analysis effectively predicted FN SLN (area under the curve = 0.84-0.86). The positive and negative predictive values of the model are 83% and 97%, respectively. Conclusion: This study supports a minimum threshold of 3 nodes for targeted nodal assessment in colorectal cancer, and establishes sufficient basis to Conclude that SLN mapping and biopsy cannot be justified in the presence of clinically apparent tumor-replaced nodes. C1 [Nissan, Aviram; Protic, Mladjan; Bilchik, Anton; Peoples, George E.; Stojadinovic, Alexander] US Mil Canc Inst, Washington, DC USA. [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Div Surg Oncol, Washington, DC 20307 USA. [Nissan, Aviram] Hadassah Hebrew Univ, Med Ctr, Dept Surg, Div Surg Oncol, Jerusalem, Israel. [Protic, Mladjan] Clin Ctr Vojvodina, Clin Abdominal Endocrine & Transplantat Surg, Novi Sad, Serbia. [Bilchik, Anton] Univ Calif Los Angeles, Dept Med, Los Angeles, CA USA. [Eberhardt, John] DecisionQ Corp, Washington, DC USA. [Peoples, George E.] Brooke Army Med Ctr, Dept Surg, Div Surg Oncol, Washington, DC USA. RP Stojadinovic, A (reprint author), US Mil Canc Inst, 6900 Georgia Ave,Room 5C27A,NW, Washington, DC USA. EM alexander.stojadinovic@amedd.army.mil NR 37 TC 15 Z9 15 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-4932 J9 ANN SURG JI Ann. Surg. PD FEB PY 2010 VL 251 IS 2 BP 265 EP 274 DI 10.1097/SLA.0b013e3181bd5187 PG 10 WC Surgery SC Surgery GA 549KC UT WOS:000274046300014 PM 20054276 ER PT J AU Buckenmaier, CC Kwon, KH Howard, RS McKnight, GM Shriver, CD Stojadinovic, A AF Buckenmaier, C. C., III Kwon, K. H. Howard, R. S. McKnight, G. M. Shriver, C. D. Stojadinovic, A. TI Double-Blinded, Placebo Controlled Prospective Randomized Trial Evaluating the Efficacy of Continuous Paravertebral Catheter Anesthesia with Paravertebral Block in Breast Cancer Surgery SO ANNALS OF SURGICAL ONCOLOGY LA English DT Meeting Abstract CT 63rd Annual Cancer Symposium of the Society-of-Surgical-Oncology CY MAR 03-07, 2010 CL St Louis, MO SP Soc Surg Oncol C1 [Buckenmaier, C. C., III; Kwon, K. H.; McKnight, G. M.] Walter Reed Army Med Ctr, Reg Anesthesia & Pain Management Initiat, Anesthesia & Operat Serv, Washington, DC 20307 USA. [Howard, R. S.] Walter Reed Army Med Ctr, Dept Clin Invest, Div Biostat, Washington, DC 20307 USA. [Shriver, C. D.; Stojadinovic, A.] Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD FEB PY 2010 VL 17 SU 1 BP S29 EP S29 PG 1 WC Oncology; Surgery SC Oncology; Surgery GA 560KY UT WOS:000274902700072 ER PT J AU Clifton, GT Clive, K Holmes, JP Patil, R Benavides, LC Gates, JD Mittendorf, EA Stojadinovic, A Ponniah, S Peoples, GE AF Clifton, G. T. Clive, K. Holmes, J. P. Patil, R. Benavides, L. C. Gates, J. D. Mittendorf, E. A. Stojadinovic, A. Ponniah, S. Peoples, G. E. TI Cumulative Findings from the E75 Peptide Vaccine Adjuvant Trials in Breast Cancer SO ANNALS OF SURGICAL ONCOLOGY LA English DT Meeting Abstract CT 63rd Annual Cancer Symposium of the Society-of-Surgical-Oncology CY MAR 03-07, 2010 CL St Louis, MO SP Soc Surg Oncol C1 [Clifton, G. T.; Clive, K.; Benavides, L. C.; Gates, J. D.; Peoples, G. E.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Holmes, J. P.] USN, San Diego Med Ctr, San Diego, CA 92152 USA. [Patil, R.] Windber Med Ctr, Windber, PA USA. [Mittendorf, E. A.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Stojadinovic, A.] Walter Reed Army Med Ctr, Washington, DC USA. [Ponniah, S.] USUHS, Canc Vaccine Dev Program, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD FEB PY 2010 VL 17 SU 1 BP S50 EP S50 PG 1 WC Oncology; Surgery SC Oncology; Surgery GA 560KY UT WOS:000274902700135 ER PT J AU Clive, K Tyler, JA Barchie, MF Sutcliffe, JB Kirkpatrick, AD Banks, KP Bell, LM Saenger, JS Peoples, GE AF Clive, K. Tyler, J. A. Barchie, M. F. Sutcliffe, J. B. Kirkpatrick, A. D. Banks, K. P. Bell, L. M. Saenger, J. S. Peoples, G. E. TI Are Increased Mastectomy Rates Based on Pretreatment MRI Findings Justified? SO ANNALS OF SURGICAL ONCOLOGY LA English DT Meeting Abstract CT 63rd Annual Cancer Symposium of the Society-of-Surgical-Oncology CY MAR 03-07, 2010 CL St Louis, MO SP Soc Surg Oncol C1 [Clive, K.; Tyler, J. A.; Barchie, M. F.; Sutcliffe, J. B.; Kirkpatrick, A. D.; Banks, K. P.; Bell, L. M.; Saenger, J. S.; Peoples, G. E.] Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD FEB PY 2010 VL 17 SU 1 BP S51 EP S51 PG 1 WC Oncology; Surgery SC Oncology; Surgery GA 560KY UT WOS:000274902700139 ER PT J AU Ellsworth, R Weyandt, JD Fantacone-Campbell, JL Deyarmin, B Ellsworth, DL Hooke, JA Shriver, CD AF Ellsworth, R. Weyandt, J. D. Fantacone-Campbell, J. L. Deyarmin, B. Ellsworth, D. L. Hooke, J. A. Shriver, C. D. TI Molecular characterization of breast cancer progression: early lesions are not genetically advanced SO ANNALS OF SURGICAL ONCOLOGY LA English DT Meeting Abstract CT 63rd Annual Cancer Symposium of the Society-of-Surgical-Oncology CY MAR 03-07, 2010 CL St Louis, MO SP Soc Surg Oncol C1 [Ellsworth, R.] Henry M Jackson Fdn Advancement Mil Med, Windber, PA USA. [Weyandt, J. D.; Deyarmin, B.; Ellsworth, D. L.] Windber Res Inst, Windber, PA USA. [Fantacone-Campbell, J. L.; Hooke, J. A.; Shriver, C. D.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD FEB PY 2010 VL 17 SU 1 BP S46 EP S46 PG 1 WC Oncology; Surgery SC Oncology; Surgery GA 560KY UT WOS:000274902700121 ER PT J AU Hwang, PF Hampton, CB Potter, BK Shoemaker, RG Graybill, JC Forsberg, JA Schaefer, RA Peoples, GE Stojadinovic, A AF Hwang, P. F. Hampton, C. B. Potter, B. K. Shoemaker, R. G. Graybill, J. C. Forsberg, J. A. Schaefer, R. A. Peoples, G. E. Stojadinovic, A. TI Impact of Local Recurrence on Extremity and Pelvic Soft Tissue Sarcoma Survival SO ANNALS OF SURGICAL ONCOLOGY LA English DT Meeting Abstract CT 63rd Annual Cancer Symposium of the Society-of-Surgical-Oncology CY MAR 03-07, 2010 CL St Louis, MO SP Soc Surg Oncol C1 [Potter, B. K.; Schaefer, R. A.; Stojadinovic, A.] Uniformed Serv Univ Hlth Sci, Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC USA. [Peoples, G. E.] Uniformed Serv Univ Hlth Sci, Brooke Army Med Ctr, US Mil Canc Inst, Ft Sam Houston, TX USA. RI Forsberg, Jonathan/K-2116-2012 NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD FEB PY 2010 VL 17 SU 1 BP S127 EP S127 PG 1 WC Oncology; Surgery SC Oncology; Surgery GA 560KY UT WOS:000274902700390 ER PT J AU Webb, RC Howard, RS Stojadinovic, A Burch, HB AF Webb, R. C. Howard, R. S. Stojadinovic, A. Burch, H. B. TI Post Operative Thyroglobulin Level: Significant Marker of Recurrent Papillary Thyroid Carcinoma SO ANNALS OF SURGICAL ONCOLOGY LA English DT Meeting Abstract CT 63rd Annual Cancer Symposium of the Society-of-Surgical-Oncology CY MAR 03-07, 2010 CL St Louis, MO SP Soc Surg Oncol C1 [Webb, R. C.; Howard, R. S.; Stojadinovic, A.; Burch, H. B.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD FEB PY 2010 VL 17 SU 1 BP S61 EP S61 PG 1 WC Oncology; Surgery SC Oncology; Surgery GA 560KY UT WOS:000274902700174 ER PT J AU Rice, RD Armstrong, PJ AF Rice, Robert D. Armstrong, Peter J. TI Brachial Artery Fibromuscular Dysplasia SO ANNALS OF VASCULAR SURGERY LA English DT Article ID DIGITAL EMBOLI; THERAPY; DISEASE AB Fibromuscular dysplasia is a rare vascular disease that is characterized as nonatherosclerotic and noninflammatory in nature. This disease most commonly afflicts the renal and cerebrovascular beds but can rarely affect the upper extremity. We present the case of a 76-year-old woman who complained of a symptom complex, congruent with Raynaud's phenomenon on the right side. The patient had evidence of distal ischemia without the classic angiographic evidence of fibromuscular dysplasia on arteriography. The abnormal arterial section of the right brachial artery was resected and grafted with reversed saphenous vein. She has had no reoccurrence of her symptoms and no stenosis of her graft over a 3-year follow-up period. C1 [Rice, Robert D.; Armstrong, Peter J.] Dwight D Eisenhower Army Med Ctr, Dept Surg, Vasc Surg Serv, Ft Gordon, GA 30905 USA. RP Rice, RD (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, Ft Gordon, GA 30905 USA. EM robert.d.rice@us.army.mil NR 13 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0890-5096 J9 ANN VASC SURG JI Ann. Vasc. Surg. PD FEB PY 2010 VL 24 IS 2 AR 255.e1 DI 10.1016/j.avsg.2009.05.012 PG 4 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 549US UT WOS:000274080400018 PM 19896327 ER PT J AU Nasveld, PE Edstein, MD Reid, M Brennan, L Harris, IE Kitchener, SJ Leggat, PA Pickford, P Kerr, C Ohrt, C Prescott, W AF Nasveld, Peter E. Edstein, Michael D. Reid, Mark Brennan, Leonard Harris, Ivor E. Kitchener, Scott J. Leggat, Peter A. Pickford, Philip Kerr, Caron Ohrt, Colin Prescott, William CA Tafenoquine Study Team TI Randomized, Double-Blind Study of the Safety, Tolerability, and Efficacy of Tafenoquine versus Mefloquine for Malaria Prophylaxis in Nonimmune Subjects SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID AUSTRALIAN DEFENSE FORCE; PLASMODIUM-FALCIPARUM MALARIA; EAST TIMOR; CONTROLLED TRIAL; PRIMAQUINE; VIVAX; CHEMOPROPHYLAXIS; PERSONNEL; TRAVELERS; REGIMENS AB This study represents the first phase III trial of the safety, tolerability, and effectiveness of tafenoquine for malaria prophylaxis. In a randomized (3:1), double-blinded study, Australian soldiers received weekly malaria prophylaxis with 200 mg tafenoquine (492 subjects) or 250 mg mefloquine (162 subjects) for 6 months on a peacekeeping deployment to East Timor. After returning to Australia, tafenoquine-receiving subjects received a placebo and mefloquine-receiving subjects received 30 mg primaquine daily for 14 days. There were no clinically significant differences between hematological and biochemical parameters of the treatment groups. Treatment-related adverse events for the two groups were similar (tafenoquine, 13.4%; mefloquine, 11.7%). Three subjects on tafenoquine (0.6%) and none on mefloquine discontinued prophylaxis because of possible drug-related adverse events. No diagnoses of malaria occurred for either group during deployment, but 4 cases (0.9%) and 1 case (0.7%) of Plasmodium vivax infection occurred among the tafenoquine and mefloquine groups, respectively, up to 20 weeks after discontinuation of medication. In a subset of subjects recruited for detailed safety assessments, treatment-related mild vortex keratopathy was detected in 93% (69 of 74) of tafenoquine subjects but none of the 21 mefloquine subjects. The vortex keratopathy was not associated with any effect on visual acuity and was fully resolved in all subjects by 1 year. Tafenoquine appears to be safe and well tolerated as malaria prophylaxis. Although the volunteers' precise exposure to malaria could not be proven in this study, tafenoquine appears to be a highly efficacious drug for malaria prophylaxis. C1 [Nasveld, Peter E.] Univ Queensland, Ctr Mil & Vet Hlth, Mayne Med Sch, Herston, Qld 4006, Australia. [Nasveld, Peter E.; Edstein, Michael D.; Reid, Mark; Brennan, Leonard; Harris, Ivor E.; Kitchener, Scott J.; Leggat, Peter A.] Australian Army Malaria Inst, Brisbane, Qld, Australia. [Pickford, Philip; Kerr, Caron] GlaxoSmithKline Res & Dev Ltd, Harlow, Essex, England. [Ohrt, Colin] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. [Prescott, William] US Army Med Mat Dev Act, Frederick, MD USA. RP Nasveld, PE (reprint author), Univ Queensland, Ctr Mil & Vet Hlth, Mayne Med Sch, Herston, Qld 4006, Australia. EM P.Nasveld@uq.edu.au RI Russell, Bruce/A-9240-2011; Kitchener, Scott/M-1885-2013 OI Russell, Bruce/0000-0003-2333-4348; Kitchener, Scott/0000-0002-2656-7588 FU U.S. Army Medical Materiel Development Activity; GlaxoSmithKline Research & Development Limited; Australian Defence Force FX Financial support was from the U.S. Army Medical Materiel Development Activity, GlaxoSmithKline Research & Development Limited, and the Australian Defence Force. NR 23 TC 36 Z9 36 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD FEB PY 2010 VL 54 IS 2 BP 792 EP 798 DI 10.1128/AAC.00354-09 PG 7 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 547BR UT WOS:000273860600029 PM 19995933 ER PT J AU Stojadinovic, A Ahuja, N Nazarian, SM Segev, DL Jacobs, L Wang, YC Eberhardt, J Zeiger, MA AF Stojadinovic, Alexander Ahuja, Nita Nazarian, Susanna M. Segev, Dorry L. Jacobs, Lisa Wang, Yongchun Eberhardt, John Zeiger, Martha A. TI Translational Research in Surgical Disease SO ARCHIVES OF SURGERY LA English DT Review ID GASTROINTESTINAL STROMAL TUMORS; MALIGNANT THYROID-TUMORS; KIDNEY PAIRED DONATION; METASTATIC COLORECTAL-CANCER; HER2-POSITIVE BREAST-CANCER; GENE-EXPRESSION; NEOINTIMAL HYPERPLASIA; ADJUVANT CHEMOTHERAPY; REVERSE-TRANSCRIPTASE; IMATINIB MESYLATE AB Objective: To review cutting-edge, novel, implemented and potential translational research and to provide a glimpse into rich, innovative, and brilliant approaches to everyday surgical problems. Data Sources: Scientific literature and unpublished results. Study Selection: Articles reviewed were chosen based on innovation and application to surgical diseases. Data Extraction: Each section was written by a surgeon familiar with cutting-edge and novel research in their field of expertise and interest. Data Synthesis: Articles that met criteria were summarized in the manuscript. Conclusions: Multiple avenues have been used for the discovery of improved means of diagnosis, treatment, and overall management of patients with surgical diseases. These avenues have incorporated the use of genomics, electrical impedence, statistical and mathematical modeling, and immunology. C1 [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Div Surg Oncol, Washington, DC 20307 USA. [Ahuja, Nita; Jacobs, Lisa; Wang, Yongchun; Zeiger, Martha A.] Johns Hopkins Univ, Sch Med, Div Endocrine & Surg Oncol, Baltimore, MD USA. [Nazarian, Susanna M.] Johns Hopkins Univ, Sch Med, Div Vasc Surg, Baltimore, MD USA. [Segev, Dorry L.] Johns Hopkins Univ, Sch Med, Dept Surg, Div Transplantat, Baltimore, MD 21205 USA. [Eberhardt, John] Healthcare DecisionQ Corp, Washington, DC USA. RP Zeiger, MA (reprint author), 600 N Wolfe St,Blalock 606, Baltimore, MD 21287 USA. EM mzeiger@jhmi.edu RI Ahuja, Nita/H-1064-2011 NR 60 TC 1 Z9 1 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0004-0010 J9 ARCH SURG-CHICAGO JI Arch. Surg. PD FEB PY 2010 VL 145 IS 2 BP 187 EP 196 PG 10 WC Surgery SC Surgery GA 554XG UT WOS:000274468900018 PM 20157088 ER PT J AU Lande, RG Tarpley, V Francis, JL Boucher, R AF Lande, R. Gregory Tarpley, Vanita Francis, Jennifer L. Boucher, Rebecca TI Combat Trauma Art Therapy Scale SO ARTS IN PSYCHOTHERAPY LA English DT Article DE Art therapy; Combat; Rating scale ID MENTAL-HEALTH PROBLEMS; IRAQ AB This study correlated an art therapy descriptive technique originally applied to adolescent burn victims with adult combat-related victims in an effort to identify art themes and graphic elements associated with post-traumatic stress disorder. The designed rating instrument, referred to as the Combat Trauma Art Therapy Scale (CTATS), consisted of 62 items aimed to detect common themes associated with war time experiences. Using the CTAS, raters examined 158 pictures, with depictions of women, violence, and combat interwoven, suggesting an ongoing struggle to cope with the emotional aftermath of recent traumatic experiences. Published by Elsevier Inc. C1 [Lande, R. Gregory; Tarpley, Vanita; Francis, Jennifer L.; Boucher, Rebecca] Walter Reed Army Med Ctr, Dept Psychiat, Washington, DC 20307 USA. RP Lande, RG (reprint author), Walter Reed Army Med Ctr, Dept Psychiat, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM rglande@medscape.com NR 11 TC 2 Z9 2 U1 2 U2 12 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0197-4556 J9 ART PSYCHOTHER JI Arts Psychother. PD FEB PY 2010 VL 37 IS 1 BP 42 EP 45 DI 10.1016/j.aip.2009.09.007 PG 4 WC Psychology, Clinical; Rehabilitation SC Psychology; Rehabilitation GA 563MN UT WOS:000275136700007 ER PT J AU Bedno, SA Li, YZ Han, WW Cowan, DN Scott, CT Cavicchia, MA Niebuhr, DW AF Bedno, Sheryl A. Li, Yuanzhang Han, Weiwei Cowan, David N. Scott, Christine T. Cavicchia, Melinda A. Niebuhr, David W. TI Exertional Heat Illness Among Overweight US Army Recruits In Basic Training SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE military; obesity; heatstroke; physical fitness ID RISK-FACTORS; UNITED-STATES; FITNESS; OBESITY; WORKERS; STRESS AB BEDNO SA, LI Y, HAN K COWAN DN, SCOTT CT, CAVICCHIA MA, NIEBUHR DW. Exertional heat illness among overweight U.S. Army recruits in basic training. Aviat Space Environ Med 2010; 81:107-11. Introduction: Heat illness has not declined in the U.S. military despite preventive measures. The increase in overweight recruits entering the U.S. military may lead to an increase in heat-related events. This study compares the risk of heat illness among U.S. Army recruits who exceeded body fat standards at accession to those who met standards. Methods: Recruits with excess body fat and qualified applicants to the Army were required to take a preaccession fitness test during the study period (February 2005 through September 2006). The test included a 5-min step test and 1-min push-up challenge, scored as pass or fail. Incidence and outpatient usage for heat illness (any beat illness, heat stroke, heat exhaustion, and other heat illness) at 90 d of service were compared in 9667 male recruits of whom 826 had excess body fat and 8841 were qualified. There were too few beat events among women for analysis. Results: The incidence odds ratio among male recruits with excess body fat compared to qualified male recruits was 3.63 (95% CI: 1.92, 6.85). Men with excess body fat had an increased incidence of heat illness with a rate ratio of 7.25 (95% CI: 4.17, 12.61). Discussion: Although there were few heat illness events, the results indicate a significantly increased risk of heat illness and outpatient utilization among male recruits with excess body fat. It was estimated that approximately 70% of the relative risk for heat illnesses in men with excess body fat during basic training was associated with exceeding body fat standards. These findings may have implications for military accession and training. C1 [Li, Yuanzhang; Han, Weiwei; Cowan, David N.; Cavicchia, Melinda A.; Niebuhr, David W.] Walter Reed Army Inst Res, Dept Epidemiol, Silver Spring, MD USA. [Bedno, Sheryl A.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Occupat & Environm Med Residency Program, Bethesda, MD 20814 USA. [Scott, Christine T.] Med Examinat Review Board, Dept Def, Colorado Springs, CO USA. RP Bedno, SA (reprint author), Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Occupat & Environm Med Residency Program, 4301 Jones Bridge Rd,Rm A-1040A, Bethesda, MD 20814 USA. EM sheryl.bedno@usuhs.mil OI Li, Yuanzhang/0000-0001-8872-4430 FU U.S. Army Accession Command FX We would like to thank Ms. Janice Gary and Ms. Vielka Rivera, Accession Medical Standards Analysis & Research Activity (AMSARA), Walter Reed Army Institute of Research, for their administrative support.; This study was funded by the U.S. Army Accession Command.; The views expressed are those of the authors and should not be construed to represent the positions of the Department of the Army or Department of Defense.; Authors and affiliations: Sheryl A. Bedno, M.D., M.P.H., Occupational and Environmental Medicine Residency, Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD; Yuanzhang Li, Ph.D., Weiwei Han, M.S., David N. Cowan, Ph.D., M.P.H., Melida A. Cavicchia, M.D., M.P.H., and David W. Niebuhr, M.D., M.P.H., Department of Epidemiology, Walter Reed Army Institute of Research, Silver Spring, MD; and Christine T. Scott, M.D., M.P.H., Department of Defense Medical Examination Review Board, Colorado Springs, CO. NR 20 TC 32 Z9 33 U1 1 U2 16 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD FEB PY 2010 VL 81 IS 2 BP 107 EP 111 DI 10.3357/ASEM.2623.2010 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 549QE UT WOS:000274067900003 PM 20131650 ER PT J AU Sethuraman, G Ryan, KL Rickards, CA Convertino, VA AF Sethuraman, Girish Ryan, Kathy L. Rickards, Caroline A. Convertino, Victor A. TI Ectopy in Trauma Patients: Cautions for Use of Heart Period Variability in Medical Monitoring SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE physiologic monitoring; heart rate variability; heart rate complexity; hypovolemia ID REMOTE TRIAGE; MORTALITY; COMPLEXITY; STRESS; BEATS; CARE AB SETHURAMAN G, RYAN KL, RICKARDS CA, CONVERTINO VA. Ectopy in trauma patients: cautions for use of heart period variability in medical monitoring. Aviat Space Environ Med 2010; 81:125-9. Introduction: Heart period variability measurements have been proposed for use in early prediction of mortality or the requirement for life-saving interventions in trauma patients. However, the presence of even one ectopic beat (EB) and/or electromechanical noise compromises the accurate calculation of heart period variability. We tested the hypothesis that ECGs from trauma patients exhibit a greater frequency of EBs than healthy human research subjects. Methods: Continuous ECGs were recorded in 20 healthy human subjects at rest, 108 healthy human subjects undergoing experimentally induced progressive central hypovolemia (via lower body negative pressure, LBNP), and 245 trauma patients. The proportions of subjects/patients with at least one EB were identified in each group. Results: ECG waveforms from 20% and 18% of healthy human subjects at rest or undergoing LBNP, respectively, contained at least one EB. ECG waveforms from 36% of the trauma patients were found to contain either EBs (35%) or electromechanical noise (1%). Conclusions: A significant number of EBs occur in healthy Subjects both at rest and during progressive reduction in central blood volume, and trauma is associated with a near doubling of this incidence. As both EBs and noise result in invalid heart period variability calculations, these metrics as currently calculated Could not be used in approximately 36% of trauma patients. The limited use in nearly two of every five trauma patients indicate that it is unlikely that continuous heart period variability measurements could substantially improve pre-hospital or emergency room decision-support in trauma. C1 [Sethuraman, Girish; Ryan, Kathy L.; Rickards, Caroline A.; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Rickards, Caroline A.] Univ Texas San Antonio, San Antonio, TX USA. RP Ryan, KL (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM kathy.ryan@amedd.army.mil FU U.S. Army Medical Research and Materiel Command Combat Casualty Care Research Program FX This work was funded by the U.S. Army Medical Research and Materiel Command Combat Casualty Care Research Program. We thank Mr. Gary Muniz and Mr. Gilbert Moralez for their superb technical assistance in analyzing data. Data were collected under Cooperative Research and Development Agreement W81XWH-06-0144 between the U.S. Army Institute of Surgical; The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.; Authors and affiliations: Girish Sethuraman, M.D., M.P.H., Kathy L. Ryan, B.S., Ph.D., Caroline A. Rickards, B.App.Sci.(Hons.), Ph.D., and Victor A. Convertino, M.A., Ph.D., U.S. Army Instititue of Surgical Research, Fort Sam Houston, TX; and Caroline A. Rickards, B.App. Sci.(Hons.), Ph.D., the University of Texas at San Antonio, San Antonio, TX. NR 23 TC 6 Z9 6 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD FEB PY 2010 VL 81 IS 2 BP 125 EP 129 DI 10.3357/ASEM.2597.2010 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 549QE UT WOS:000274067900006 PM 20131653 ER PT J AU Song, Y Elias, V Wong, CP Scrimgeour, AG Ho, E AF Song, Yang Elias, Valerie Wong, Carmen P. Scrimgeour, Angus G. Ho, Emily TI Zinc transporter expression profiles in the rat prostate following alterations in dietary zinc SO BIOMETALS LA English DT Article DE Zinc transporter; ZnT2; Prostate; Marginal zinc deficiency ID CITRATE METABOLISM; EPITHELIAL-CELLS; DOWN-REGULATION; MAMMARY CELLS; DNA-DAMAGE; CANCER; DEFICIENCY; LACTATION; PROLACTIN; VARIANTS AB Zinc plays important roles in numerous cellular activities and physiological functions. Intracellular zinc levels are strictly maintained by zinc homeostatic mechanisms. Zinc concentrations in the prostate are the highest of all soft tissues and could be important for prostate health. However, the mechanisms by which the prostate maintains high zinc levels are still unclear. In addition, the response of the prostate to alterations in dietary zinc is unknown. The current study explored cellular zinc levels and zinc transporter expression profiles in the lobes of the prostate during dietary marginal zinc depletion. Rats were given either zinc-adequate (ZA, 30 mg Zn/kg) or marginal zinc-deficient (MZD, 5 mg Zn/kg) diet for 9 weeks. In addition, a subgroup of the MZD rats was supplemented with phytase (1,500 unit/kg diet) to improve zinc bioavailability. We found that both zinc concentrations and ZnT2 expression in the prostate dorsolateral lobes were substantially higher than in the ventral lobes (P < 0.05). Marginal zinc depletion significantly decreased ZnT2 expression in the dorsolateral lobes (P < 0.05), and phytase supplementation had a trend to increase ZnT2 expression. In addition, of all measured zinc transporters, only ZnT2 mRNA abundance was significantly correlated to the zinc concentrations in the dorsolateral lobe. No correlations were found between zinc transporter expression and zinc concentrations in the ventral lobes. These results indicate that ZnT2 may play a significant role in the maintenance of zinc homeostasis in the prostate. C1 [Song, Yang; Elias, Valerie; Wong, Carmen P.; Ho, Emily] Oregon State Univ, Dept Nutr & Exercise Sci, Corvallis, OR 97331 USA. [Scrimgeour, Angus G.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Ho, Emily] Oregon State Univ, Linus Pauling Inst Sci & Med, Corvallis, OR 97331 USA. RP Ho, E (reprint author), Oregon State Univ, Dept Nutr & Exercise Sci, 103 Milam Hall, Corvallis, OR 97331 USA. EM emily.ho@oregonstate.edu RI Song, Yang/D-6331-2011 FU Oregon AES [OR00735]; Environmental Health Science Center at Oregon State University (NIEHS) [P30 ES00210]; US Army MRMC FX We thank Dr. Shannon Kelleher for the generous gift of ZnT2 antibodies. We gratefully acknowledge the WM Keck Collaboratory at Oregon State University for their assistance in conducting these studies. This study was funded by Oregon AES (OR00735), and the Environmental Health Science Center at Oregon State University (NIEHS P30 ES00210) and by the US Army MRMC. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Army or the Department of Defense. NR 32 TC 13 Z9 13 U1 0 U2 5 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0966-0844 J9 BIOMETALS JI Biometals PD FEB PY 2010 VL 23 IS 1 BP 51 EP 58 DI 10.1007/s10534-009-9266-8 PG 8 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 536ZX UT WOS:000273083600005 PM 19760107 ER PT J AU Long, JW Laskoski, M Keller, TM Pettigrew, KA Zimmerman, TN Qadri, SB Peterson, GW AF Long, Jeffrey W. Laskoski, Matthew Keller, Teddy M. Pettigrew, Katherine A. Zimmerman, T'revor N. Qadri, Syed B. Peterson, Gregory W. TI Selective-combustion purification of bulk carbonaceous solids to produce graphitic nanostructures SO CARBON LA English DT Article ID HYDROGEN STORAGE; NANOTUBE FORMATION; IN-SITU; NANOPARTICLE COMPOSITIONS; CATALYTIC GRAPHITIZATION; RAMAN-SPECTROSCOPY; OXIDATION; ENERGY; NANOFIBERS; SPECTRA AB We demonstrate the use of simple thermal oxidation processes to purify bulk carbon composites produced from thermosets, which were formulated from precursor compositions containing a melt-processible organometallic Ni catalyst in an excess of carbon source. The as-pyrolyzed carbonaceous solids comprise Ni nanoparticles and interpenetrating amorphous and graphitic carbon domains, where the fraction of crystalline carbon is determined primarily by the carbonization temperature. We exploit the adventitious amorphous carbon phase as a pore-forming agent, which is subsequently removed by selective combustion, exposing the embedded graphitic nanostructures and associated metal catalyst nanoparticles, while still retaining the macroscopic dimensions of the initial thermoset polymeric solid. The pore network formed by removal of the amorphous carbon facilitates the mass transport of gas-phase molecules, such as ammonia, to the internal surfaces of the purified carbon solid. The ability to produce nanostructured. graphitic carbons in bulk solid forms using simple processing methods will facilitate their development for applications ranging from electrochemical energy storage to gas sorption/filtration. Published by Elsevier Ltd. C1 [Long, Jeffrey W.; Laskoski, Matthew; Keller, Teddy M.; Pettigrew, Katherine A.; Zimmerman, T'revor N.] USN, Res Lab, Div Chem, Washington, DC 20375 USA. [Qadri, Syed B.] USN, Res Lab, Div Mat Sci & Technol, Washington, DC 20375 USA. [Peterson, Gregory W.] USA, Res Dev & Engn Command, Edgewood Chem Biol Ctr, Res & Technol Directorate,CBR Filtrat Team, Aberdeen Proving Ground, MD 21010 USA. RP Long, JW (reprint author), USN, Res Lab, Div Chem, Code 6170, Washington, DC 20375 USA. EM jeffrey.long@nrl.navy.mil FU US Office of Naval Research; Defense Threat Reduction Agency FX Financial support for this research was provided by the US Office of Naval Research and the Defense Threat Reduction Agency. Bryan Schindler (SAIC, Abingdon, MD) per-formed the ammonia-breakthrough measurements. NR 45 TC 16 Z9 16 U1 3 U2 22 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0008-6223 J9 CARBON JI Carbon PD FEB PY 2010 VL 48 IS 2 BP 501 EP 508 DI 10.1016/j.carbon.2009.09.068 PG 8 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 532QK UT WOS:000272764300025 ER PT J AU Martinez, O Johnson, J Manicassamy, B Rong, LJ Olinger, GG Hensley, LE Basler, CF AF Martinez, Osvaldo Johnson, Joshua Manicassamy, Balaji Rong, Lijun Olinger, Gene G. Hensley, Lisa E. Basler, Christopher F. TI Zaire Ebola virus entry into human dendritic cells is insensitive to cathepsin L inhibition SO CELLULAR MICROBIOLOGY LA English DT Article ID HEMORRHAGIC-FEVER; ANTIGEN PRESENTATION; VP40 PROTEIN; GLYCOPROTEIN; PATHOGENESIS; INFECTION; PROTEOLYSIS; MATURATION; PARTICLES; MARBURG AB Cathepsins B and L contribute to Ebola virus (EBOV) entry into Vero cells and mouse embryonic fibroblasts. However, the role of cathepsins in EBOV-infection of human dendritic cells (DCs), important targets of infection in vivo, remains undefined. Here, EBOV-like particles containing a beta-lactamase-VP40 fusion reporter and Ebola virus were used to demonstrate the cathepsin dependence of EBOV entry into human monocyte-derived DCs. However, while DC infection is blocked by cathepsin B inhibitor, it is insensitive to cathepsin L inhibitor. Furthermore, DCs pre-treated for 48 h with TNF alpha were generally less susceptible to entry and infection by EBOV. This decrease in infection was associated with a decrease in cathepsin B activity. Thus, cathepsin L plays a minimal, if any, role in EBOV infection in human DCs. The inflammatory cytokine TNF alpha modulates cathepsin B activity and affects EBOV entry into and infection of human DCs. C1 [Martinez, Osvaldo; Manicassamy, Balaji; Basler, Christopher F.] Mt Sinai Sch Med, Dept Microbiol, New York, NY 10029 USA. [Johnson, Joshua; Olinger, Gene G.; Hensley, Lisa E.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Rong, Lijun] Univ Illinois, Dept Microbiol & Immunol, Chicago, IL 60607 USA. RP Basler, CF (reprint author), Mt Sinai Sch Med, Dept Microbiol, New York, NY 10029 USA. EM chris.basler@mssm.edu OI Olinger, Gene/0000-0001-7338-0292; Martinez, Osvaldo/0000-0001-7335-4342; Johnson, Joshua/0000-0002-5677-3841 FU NIH, (Northeast Biodefense Center-Lipkin) [U54 AI057158]; NIH [AI059536] FX This work was supported in part by funds from the NIH, including U54 AI057158 (Northeast Biodefense Center-Lipkin) and AI059536 to C.F.B. We would like to thank Alejandra Galvez for producing and purifying some of the virus-like particles used in this study. Opinions, interpretations, conclusions and recommendations are those of the authors and are not necessarily endorsed by the US Army. NR 39 TC 26 Z9 28 U1 0 U2 8 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1462-5814 J9 CELL MICROBIOL JI Cell Microbiol. PD FEB PY 2010 VL 12 IS 2 BP 148 EP 157 DI 10.1111/j.1462-5822.2009.01385.x PG 10 WC Cell Biology; Microbiology SC Cell Biology; Microbiology GA 543SX UT WOS:000273599900003 PM 19775255 ER PT J AU Chun, HM Fieberg, AM Hullsiek, KH Lifson, AR Crum-Cianflone, NF Weintrob, AC Ganesan, A Barthel, RV Bradley, WP Agan, BK Landrum, ML AF Chun, Helen M. Fieberg, Ann M. Hullsiek, Katherine Huppler Lifson, Alan R. Crum-Cianflone, Nancy F. Weintrob, Amy C. Ganesan, Anuradha Barthel, Robert V. Bradley, William P. Agan, Brian K. Landrum, Michael L. CA HIV Working Grp TI Epidemiology of Hepatitis B Virus Infection in a US Cohort of HIV-Infected Individuals during the Past 20 Years SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; ACTIVE ANTIRETROVIRAL THERAPY; UNITED-STATES; RISK-FACTORS; C VIRUS; HEPATOTOXICITY; PREVALENCE; RECOMMENDATIONS; ANTIBODIES; MANAGEMENT AB Background. The epidemiologic trends of hepatitis B virus (HBV) infection in human immunodeficiency virus (HIV)-infected patients over the past 20 years are largely unknown. Methods. Prevalence and risk factors for HBV infection overall, at the time of HIV infection, and after HIV infection were examined in an ongoing observational HIV cohort study. Risk factors for HBV infection at the time of diagnosis of HIV infection were evaluated using logistic regression, and risk of incident HBV infection after diagnosis of HIV infection was evaluated using Cox proportional hazards models. Results. Of the 2769 evaluable participants, 1078 (39%) had HBV infection, of whom 117 (11%) had chronic HBV infection. The yearly cross-sectional prevalence of HBV infection decreased from a peak of 49% in 1995 to 36% in 2008 (P < .001). The prevalence of HBV infection at the time of diagnosis of HIV infection decreased during 1989-2008 from 34% to 9% (P < .001). The incidence of HBV infection after diagnosis of HIV infection decreased from 4.0 cases per 100 person-years during the pre-highly active antiretroviral therapy (HAART) era to 1.1 cases per 100 person-years during the HAART era (P < .001); however, this incidence remained unchanged during 2000-2008 (P = .49), with 120% of HBV infections occurring after HIV infection being chronic. Decreased risk of HBV infection after diagnosis of HIV infection was associated with higher CD4 cell count and the use of HBV-active HAART. Receipt of >= 1 dose of HBV vaccine was not associated with reduced risk of HBV infection after diagnosis of HIV infection. Conclusions. Although the burden of HBV infection overall is slowly decreasing among HIV-infected individuals, the persistent rate of HBV infection after diagnosis of HIV infection raises concern that more-effective prevention strategies may be needed to significantly reduce the prevalence of HBV infection in this patient population. C1 [Chun, Helen M.] Naval Hlth Res Ctr, San Diego, CA USA. [Crum-Cianflone, Nancy F.] Naval Med Ctr San Diego, San Diego, CA USA. [Fieberg, Ann M.; Hullsiek, Katherine Huppler; Lifson, Alan R.] Univ Minnesota, Minneapolis, MN USA. [Fieberg, Ann M.; Hullsiek, Katherine Huppler; Lifson, Alan R.; Crum-Cianflone, Nancy F.; Weintrob, Amy C.; Ganesan, Anuradha; Bradley, William P.; Agan, Brian K.; Landrum, Michael L.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Bethesda, MD USA. [Weintrob, Amy C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Barthel, Robert V.] Naval Med Ctr Portsmouth, Portsmouth, VA USA. [Bradley, William P.; Landrum, Michael L.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. RP Landrum, ML (reprint author), Brooke Army Med Ctr, MCHE MDI, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM mlandrum@idcrp.org RI Marconi, Vincent/N-3210-2014; OI Marconi, Vincent/0000-0001-8409-4689; Agan, Brian/0000-0002-5114-1669 FU Uniformed Services University of the Health Sciences (USUHS); Department of Defence; Henry M. Jackson Foundation; National Institutes of Health, National Institute of Allergy and Infectious Diseases [HU0001-05-2-0011] FX Infectious Disease Clinical Research Program (IDCRP) of the Uniformed Services University of the Health Sciences (USUHS). The IDCRP is a Department of Defence tri-service program executed through USUHS and the Henry M. Jackson Foundation for the Advancement of Military Medicine, in collaboration with Health and Human Services, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Division of Clinical Research through Interagency Agreement HU0001-05-2-0011. NR 38 TC 28 Z9 30 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD FEB 1 PY 2010 VL 50 IS 3 BP 426 EP 436 DI 10.1086/649885 PG 11 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 542NG UT WOS:000273500300019 PM 20047484 ER PT J AU Fracisco, SD Deye, G House, B Bennett, K Stewart, A Angov, E Rothstein, Y Magill, A Ohrt, C AF Fracisco, S. D. Deye, G. House, B. Bennett, K. Stewart, A. Angov, E. Rothstein, Y. Magill, A. Ohrt, C. TI THE PROCESS TOWARD QUALIFICATION OF A CANDIDATE BIOMARKER, MEROZOITE SURFACE PROTEIN-1-42 ANTIBODIES, AS A BIOMARKER IN MALARIA CHEMOPROPHYLAXIS TRIALS. SO CLINICAL PHARMACOLOGY & THERAPEUTICS LA English DT Meeting Abstract CT 111th Annual Meeting of the American-Society-for-Clinical-Pharmacology-and-Therapeutics CY MAR 17-20, 2010 CL Atlanta, GA SP Amer Soc Clin Pharmacol & Therapeut C1 [Fracisco, S. D.; Deye, G.; Bennett, K.; Angov, E.; Rothstein, Y.; Magill, A.; Ohrt, C.] Walter Reed Army Inst Res, Silver Spring, MD USA. [House, B.] Naval Med Res Ctr, Silver Spring, MD USA. [Stewart, A.] Med Res Unit, Nairobi, Kenya. NR 0 TC 0 Z9 0 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0009-9236 J9 CLIN PHARMACOL THER JI Clin. Pharmacol. Ther. PD FEB PY 2010 VL 87 SU 1 BP S14 EP S14 PG 1 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 550PY UT WOS:000274141600044 ER PT J AU Therrien, RJ Ergut, A Levendis, YA Richter, H Howard, JB Carlson, JB AF Therrien, Richard J. Ergut, Ali Levendis, Yiannis A. Richter, Henning Howard, Jack B. Carlson, Joel B. TI Investigation of critical equivalence ratio and chemical speciation in flames of ethylbenzene-ethanol blends SO COMBUSTION AND FLAME LA English DT Article DE Soot onset; Ethanol; Ethylbenzene; Combustion; PAH; Premixed flames; Kinetic modeling ID POLYCYCLIC AROMATIC-HYDROCARBONS; SOOT ONSET CHEMISTRY; ATMOSPHERIC-PRESSURE; PREMIXED FLAMES; COMBUSTION CHARACTERISTICS; PARTICULATE-EMISSIONS; FUEL-RICH; PAH; TEMPERATURE; POLYSTYRENE AB This work investigates five different one-dimensional, laminar, atmospheric pressure, premixed ethanol/ethylbenzene flames (0%, 25%, 50%, 75% and 90% ethanol by weight) at their soot onset threshold (phi(critical)). Liquid ethanol/ethylbenzene mixtures were pre-vaporized in nitrogen, blended with an oxygen-nitrogen mixture and, upon ignition, burned in premixed one-dimensional flames at atmospheric pressure. The flames were controlled so that each was at its visual soot onset threshold, and all had similar temperature profiles (determined by thermocouples). Fixed gases, light volatile hydrocarbons, polycyclic aromatic hydrocarbons (PAH), and oxygenated aromatic hydrocarbons were directly sampled at three locations in each flame. The experimental results were compared with a detailed kinetic model, and the modeling results were used to perform a reaction flux analysis of key species. The critical equivalence ratio was observed to increase in a parabolic fashion as ethanol concentration increased in the fuel mixture. The experimental results showed increasing trends of methane, ethane, and ethylene with increasing concentrations of ethanol in the flames. Carbon monoxide was also seen to increase significantly with the increase of ethanol in the flame, which removes carbon from the PAH and soot formation pathways. The PAH and oxygenated aromatic hydrocarbon values were very similar in the 0%, 25% and 50% ethanol flames, but significantly lower in the 75% and 90% ethanol flames. These results were in general agreement with the model and were reflected by the model soot predictions. The model predicted similar soot profiles for the 0%, 25% and 50% ethanol flames, however it predicted significantly lower values in the 75% and 90% ethanol flames. The reaction flux analysis revealed benzyl to be a major contributor to single and double ring aromatics (i.e., benzene and naphthalene), which was identified in a similar role in nearly sooting or highly sooting ethylbenzene flames. The presence of this radical was significantly reduced as ethanol concentration was increased in the flames, and this effect in combination with the lower carbon to oxygen ratios and the enhanced formation of carbon monoxide, are likely what allowed higher equivalence ratios to be reached without forming soot. (C) 2009 The Combustion Institute. Published by Elsevier Inc. All rights reserved. C1 [Therrien, Richard J.; Ergut, Ali; Levendis, Yiannis A.] Northeastern Univ, Boston, MA 02115 USA. [Richter, Henning; Howard, Jack B.] MIT, Cambridge, MA 02139 USA. [Carlson, Joel B.] USA, SBCCOM, Natick Soldier Ctr, Natick, MA 01760 USA. RP Levendis, YA (reprint author), Northeastern Univ, Boston, MA 02115 USA. EM y.levendis@neu.edu NR 35 TC 14 Z9 15 U1 0 U2 10 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0010-2180 J9 COMBUST FLAME JI Combust. Flame PD FEB PY 2010 VL 157 IS 2 BP 296 EP 312 DI 10.1016/j.combustflame.2009.07.023 PG 17 WC Thermodynamics; Energy & Fuels; Engineering, Multidisciplinary; Engineering, Chemical; Engineering, Mechanical SC Thermodynamics; Energy & Fuels; Engineering GA 545AB UT WOS:000273702400011 ER PT J AU Burke, RL West, MW Erwin-Cohen, R Selby, EB Fisher, DE Twenhafel, NA AF Burke, Robin L. West, Michael W. Erwin-Cohen, Rebecca Selby, Edward B. Fisher, Diana E. Twenhafel, Nancy A. TI Alterations in Cytokines and Effects of Dexamethasone Immunosuppression during Subclinical Infections of Invasive Klebsiella pneumoniae with Hypermucoviscosity Phenotype in Rhesus (Macaca mulatta) and Cynomolgus (Macaca fascicularis) Macaques SO COMPARATIVE MEDICINE LA English DT Article ID PYOGENIC LIVER-ABSCESS; NONHUMAN-PRIMATES; BORRELIA-BURGDORFERI; VIRULENCE FACTOR; NORTH-AMERICA; LYME-DISEASE; SEROTYPE K1; MAGA; TAIWAN; COMMUNITY AB Invasive Klebsiella pneumoniae with the hypermucoviscosity phenotype (HMV K. pneumoniae) is an emerging human pathogen that also has been attributed to fatal multisystemic disease in African green monkeys at our institution. Combining a cluster of subclinically infected macaques identified in March and April 2008 and the animals documented during a subsequent survey of more than 300 colony nonhuman primates yielded a total of 9 rhesus macaques and 6 cynomolgus macaques that were subclinically infected. In an attempt to propagate the responsible HMV K. pneumoniae strain, a subset of these animals was immunosuppressed with dexamethasone. None of the treated animals developed clinical disease consistent with the multisystemic disease that affected colony African green monkeys. However, cytokine analysis revealed significant alterations of secreted cytokines in macaques subclinically infected with HMV K. pneumoniae when compared with noninfected macaques, thereby calling into question the suitability of animals subclinically infected with HMV K. pneumoniae for use in immunologic or infectious disease research. C1 [Burke, Robin L.] USA, Med Res Inst Infect Dis, Vet Med Div, Ft Detrick, MD 21702 USA. [West, Michael W.; Erwin-Cohen, Rebecca] USA, Med Res Inst Infect Dis, Ctr Aerobiol Sci Div, Ft Detrick, MD 21702 USA. [Selby, Edward B.; Fisher, Diana E.] USA, Med Res Inst Infect Dis, Div Med, Ft Detrick, MD 21702 USA. [Twenhafel, Nancy A.] USA, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. RP Burke, RL (reprint author), USA, Med Res Inst Infect Dis, Vet Med Div, Ft Detrick, MD 21702 USA. FU US Army Medical Research Institute of Infectious Diseases [150874] FX The research described herein was sponsored by the US Army Medical Research Institute of Infectious Diseases under Research Plan Number 150874 NR 55 TC 2 Z9 3 U1 2 U2 4 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1532-0820 J9 COMPARATIVE MED JI Comparative Med. PD FEB PY 2010 VL 60 IS 1 BP 62 EP 70 PG 9 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 562YH UT WOS:000275091400010 PM 20158951 ER PT J AU Landrum, H Prybutok, VR Zhang, XN AF Landrum, Hollis Prybutok, Victor R. Zhang, Xiaoni TI The moderating effect of occupation on the perception of information services quality and success SO COMPUTERS & INDUSTRIAL ENGINEERING LA English DT Article DE Service quality; Information system success; Information quality; System quality; Satisfaction ID CONFIRMATORY FACTOR-ANALYSIS; SATISFACTION INSTRUMENT; USER SATISFACTION; MCLEAN MODEL; PERFORMANCE; TECHNOLOGY; SYSTEMS; ACCEPTANCE; EXTENSION; VALIDITY AB Service quality represents a continual concern for practitioners and academicians. While traditional applications of SERVQUAL and SERVPERF have provided fruitful results in service quality research, these instruments are not focused on the information service area, although a number of researchers suggest that service quality be included as an information success measure. In this study, we proposed a modified IS success model that includes service quality as one of the success factors and examine occupation as a moderator of that model. We examined digital information service quality delivered in army libraries and our results contribute to the literature in several areas. We evaluate information system service quality from the perspective of occupation (technical professionals versus administrators). We examined the effect of occupation on perceptions as measured by SERVPERF and validate SERVPERF's dimensions in this environment, In addition, we assessed the moderating effect of occupation on IS success factors. Our results validated the proposed model and provided insight into the moderating effect of occupation on service quality and IS success factors. The results of this investigation provide practical implications for IS service quality because they support the need to consider service delivery based on occupation. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Zhang, Xiaoni] No Kentucky Univ, Dept Business Informat, Highland Hts, KY 41099 USA. [Landrum, Hollis] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39183 USA. [Prybutok, Victor R.] Univ N Texas, Coll Business Adm, Informat Technol & Decis Sci Dept, Denton, TX 76203 USA. RP Zhang, XN (reprint author), No Kentucky Univ, Dept Business Informat, Highland Hts, KY 41099 USA. EM hlandrum@att.net; prybutok@unt.edu; zhangx@nku.edu OI Prybutok, Victor/0000-0003-3810-9039 NR 57 TC 8 Z9 9 U1 4 U2 19 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0360-8352 J9 COMPUT IND ENG JI Comput. Ind. Eng. PD FEB PY 2010 VL 58 IS 1 BP 133 EP 142 DI 10.1016/j.cie.2009.09.006 PG 10 WC Computer Science, Interdisciplinary Applications; Engineering, Industrial SC Computer Science; Engineering GA 558SW UT WOS:000274767500015 ER PT J AU Pidcoke, HF Wade, CE Mann, EA Salinas, J Cohee, BM Holcomb, JB Wolf, SE AF Pidcoke, Heather F. Wade, Charles E. Mann, Elizabeth A. Salinas, Jose Cohee, Brian M. Holcomb, John B. Wolf, Steven E. TI Anemia causes hypoglycemia in intensive care unit patients due to error in single-channel glucometers: Methods of reducing patient risk SO CRITICAL CARE MEDICINE LA English DT Article DE glucose; insulin; anemia; point-of-care systems; hematocrit; glucose oxidase; critical care; intensive care unit; glucometer; glucose measurement ID CRITICALLY-ILL PATIENTS; BLOOD-GLUCOSE MEASUREMENTS; INSULIN THERAPY; TRANSFUSION STRATEGIES; POINT; ASSOCIATION; CAPILLARY; ACCURACY; ICU AB Objective: Intensive insulin therapy in the critically ill reduces mortality but carries the risk of increased hypoglycemia. Point-of-care blood glucose analysis is standard; however, anemia causes falsely high values and potentially masks hypoglycemia. Permissive anemia is practiced routinely in most intensive care units. We hypothesized that point-of-care glucometer error due to anemia is prevalent, can be corrected mathematically, and correction uncovers occult hypoglycemia during intensive insulin therapy. Design: The study has both retrospective and prospective phases. We reviewed data to verify the presence of systematic error, determine the source of error, and establish the prevalence of anemia. We confirmed our findings by reproducing the error in an in vitro model. Prospective data were used to develop a correction formula validated by the Monte Carlo method. Correction was implemented in a burn intensive care unit and results were evaluated after 9 mos. Setting: Burn and trauma intensive care units at a single research institution. Patients/Subjects: Samples for in vitro studies were taken from healthy volunteers. Samples for formula development were from critically ill patients who received intensive insulin therapy. Interventions: Insulin doses were calculated based on predicted serum glucose values from corrected point-of-care glucometer measurements. Measurements and Main Results: Time-matched point-of-care glucose, laboratory glucose, and hematocrit values. We previously found that anemia (hematocrit <34%) produces systematic error in glucometer measurements. The error was correctible with a mathematical formula developed and validated, using prospectively collected data. Error of uncorrected point-of-care glucose ranged from 19% to 29% (p < .001), improving to <= 5% after mathematical correction of prospective data. Comparison of data pairs before and after correction formula implementation demonstrated a 78% decrease in the prevalence of hypoglycemia in critically ill and anemic patients treated with insulin and tight glucose control (p < .001). Conclusions: A mathematical formula that corrects erroneous point-of-care glucose values due to anemia in intensive care unit patients reduces the prevalence of hypoglycernia during intensive insulin therapy. (Crit Care Med 2010; 38:471-476) C1 [Pidcoke, Heather F.; Wade, Charles E.; Mann, Elizabeth A.; Salinas, Jose; Cohee, Brian M.; Holcomb, John B.; Wolf, Steven E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Pidcoke, Heather F.; Wade, Charles E.; Holcomb, John B.; Wolf, Steven E.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA. RP Pidcoke, HF (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM heather.pidcoke@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 FU NIGMS NIH HHS [1 R01 GM063120-04, R01 GM063120] NR 29 TC 30 Z9 31 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD FEB PY 2010 VL 38 IS 2 BP 471 EP 476 DI 10.1097/CCM.0b013e3181bc826f PG 6 WC Critical Care Medicine SC General & Internal Medicine GA 547ZF UT WOS:000273927700015 PM 19789438 ER PT J AU Tran, DT Chernova, NA Chu, D Oliver, AG Oliver, SRJ AF Tran, Dat T. Chernova, Natasha A. Chu, Deryn Oliver, Allen G. Oliver, Scott R. J. TI 3-D Metal-Organic Framework Based on Cationic 2-D Cuprate Layers: Cu-3(OH)(4)[C10H6(SO3)(2)] SO CRYSTAL GROWTH & DESIGN LA English DT Article ID BONDED HOST FRAMEWORKS; COORDINATION POLYMERS; STRUCTURAL DIVERSITY; NETWORKS; COMPLEXES; INCLUSION; NAPHTHALENE-2,6-DISULFONATE; 1,5-NAPHTHALENEDISULFONATE; CADMIUM(II); SEPARATION AB We describe herein a three-dimensional Cu(II) based metal-organic framework, copper hydroxide 2,6-naphthalenedisulfonate, Cu-3(OH)(4)[C10H6(SO3)(2)]. The compound contains embedded positively charged 2-D copper oxide layers. This higher dimensionality of inorganic connectivity leads to far greater thermal stability (375 degrees C vs 245 degrees C) over our previously reported three-dimensional metal-organic framework containing embedded 1-D cuprate chains. Single crystal data for this material are as follows: FW = 544.92, monoclinic, space group P2(1)/c, a = 13.549(5) angstrom, b = 5.503(2) angstrom, c = 9.512(4) angstrom, beta = 90.031(6)degrees, V = 709.2(5) angstrom(3), D-c = 2.552 g.cm(-3), and Z = 4. The structure, crystallinity, morphology, and properties of the material are discussed. The magnetic susceptibility exhibits a broad maximum centered at 80 K, indicative of low-dimensional antiferromagnetic interactions. Control of inorganic dimensionality embedded within an MOF is an often overlooked yet key feature in determining the stability and important properties of MOFs such as adsorption, conductivity, and magnetism. C1 [Tran, Dat T.; Chu, Deryn] USA, Res Lab, Adelphi, MD 20783 USA. [Chernova, Natasha A.] SUNY Binghamton, Inst Mat Res, Binghamton, NY 13902 USA. [Oliver, Allen G.; Oliver, Scott R. J.] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA. RP Tran, DT (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM dat.tran1@arl.army.mil FU NSF [DMR-0506279]; U.S. Department of Energy, Office of Energy Sciences [DEAC02-05CH11231] FX The Army Research Laboratory is acknowledged for financial support of this research. S.O. acknowledges financial support from an NSF Career Award (DMR-0506279). Samples for synchrotron crystallographic analysis were submitted through the SCrALS (Set-vice Crystallography at Advanced Light Source) program. The ALS is supported by the U.S. Department of Energy, Office of Energy Sciences, under Contract DEAC02-05CH11231. NR 55 TC 14 Z9 14 U1 7 U2 62 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1528-7483 J9 CRYST GROWTH DES JI Cryst. Growth Des. PD FEB PY 2010 VL 10 IS 2 BP 874 EP 879 DI 10.1021/cg901222k PG 6 WC Chemistry, Multidisciplinary; Crystallography; Materials Science, Multidisciplinary SC Chemistry; Crystallography; Materials Science GA 559PC UT WOS:000274837000057 ER PT J AU Buckenmaier, C Brandon-Edwards, H Borden, D Wright, J AF Buckenmaier, Chester C., III Brandon-Edwards, Hisani Borden, David, Jr. Wright, John TI Treating Pain on the Battlefield: A Warrior's Perspective SO CURRENT PAIN AND HEADACHE REPORTS LA English DT Review DE Battlefield analgesia; Pain; Regional anesthesia; Acute pain ID PERIPHERAL-NERVE BLOCK; ENDURING-FREEDOM; GLOBAL WAR; MANAGEMENT; SOLDIERS; AFGHANISTAN; ANESTHESIA; CASUALTIES; ANALGESIA; TERRORISM AB The current conflicts in Afghanistan (Operation Enduring Freedom; commenced October 2001) and Iraq (Operation Iraqi Freedom; commenced March 2003) have been remarkable due to the more than 90% survival rate among wounded warriors. Although this statistic is a historic achievement by the military's medical services, other medical issues have taken on greater emphasis as more casualties from war survive than ever before. Pain management of United States wounded, in particular, has been a medical issue of increasing importance, as modern understanding of the detrimental effects of pain on recovery and rehabilitation becomes clearer. In this review, a warrior's perspective of military pain management is explored and potential for improvement discussed. C1 [Buckenmaier, Chester C., III; Brandon-Edwards, Hisani; Borden, David, Jr.; Wright, John] Walter Reed Army Med Ctr, Def & Vet Pain Management Initiat, Washington, DC 20307 USA. RP Buckenmaier, C (reprint author), Walter Reed Army Med Ctr, Def & Vet Pain Management Initiat, Bldg 2,Ward 44,Room 4434, Washington, DC 20307 USA. EM baybuck@gmail.com; hisanie@gmail.com; david.borden@usmc.mil; john.wright@us.army.mil FU Walter Reed Army Medical Center, Department of Anesthesia; John P. Murtha Neuroscience and Pain Institute FX Departmental support: Walter Reed Army Medical Center, Department of Anesthesia. Congressional grant: John P. Murtha Neuroscience and Pain Institute. No other potential conflicts of interest relevant to this article were reported. NR 26 TC 6 Z9 6 U1 0 U2 4 PU CURRENT MEDICINE GROUP PI PHILADELPHIA PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA SN 1531-3433 J9 CURR PAIN HEADACHE R JI Curr. Pain Headache Rep. PD FEB PY 2010 VL 14 IS 1 BP 1 EP 7 DI 10.1007/s11916-009-0090-1 PG 7 WC Clinical Neurology SC Neurosciences & Neurology GA 559SC UT WOS:000274845900001 PM 20425208 ER PT J AU Ely, BR Cheuvront, SN AF Ely, Brett R. Cheuvront, Samuel N. TI EFFICACY OF NUTRITIONAL ERGOGENIC AIDS IN HOT ENVIRONMENTS SO CURRENT TOPICS IN NUTRACEUTICAL RESEARCH LA English DT Article DE Caffeine; Carbohydrate; Endurance Performance; Heat ID CARBOHYDRATE-ELECTROLYTE REPLACEMENT; PROLONGED EXERCISE; CAFFEINE INGESTION; AMBIENT-TEMPERATURE; RUNNING PERFORMANCE; PERCEIVED EXERTION; INTENSE EXERCISE; CENTRAL FATIGUE; HEAT-STRESS; TIME-TRIAL AB Many athletes seeking a competitive edge rely on nutritional ergogenic aids to improve performance. Carbohydrate (CHO) and caffeine (CAF) supplementation appear efficacious at enhancing endurance exercise performance when studied under ideal circumstances, but the unique challenges imposed by environmental stressors such as heat may minimize or negate these effects. Similar to findings in temperate or cool environments, CHO intake during endurance exercise in hot environments produces a consistent performance benefit. But in contrast to the benefits observed in moderate environments, CAF affords no apparent performance advantage in the heat. These findings raise interesting questions about nutritional ergogenic mechanisms of action and offer direction for future research. C1 [Cheuvront, Samuel N.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Cheuvront, SN (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM Samuel.n.cheuvront@us.army.mil NR 50 TC 2 Z9 2 U1 1 U2 5 PU NEW CENTURY HEALTH PUBLISHERS, LLC PI COPPELL PA PO BOX 175, COPPELL, TX 75019 USA SN 1540-7535 J9 CURR TOP NUTRACEUT R JI Curr. Top. Nutraceutical Res. PD FEB PY 2010 VL 8 IS 1 BP 1 EP 6 PG 6 WC Nutrition & Dietetics; Pharmacology & Pharmacy SC Nutrition & Dietetics; Pharmacology & Pharmacy GA 606HW UT WOS:000278414600001 ER PT J AU Stetz, MC Makela, A Folen, R Wiederhold, BK AF Stetz, Melba C. Makela, Anna Folen, Ray Wiederhold, Brenda K. TI CyberStudies: Lessons from the Trenches SO CYBERPSYCHOLOGY BEHAVIOR AND SOCIAL NETWORKING LA English DT Article ID MENTAL-HEALTH; IMPACT AB Many individuals suffer from anxiety, stress, and depression and those serving in the U. S. military are no exception. Warfighters keep returning from theater with combat stress. Several of these military service members are also technology oriented and tend to prefer performing their daily life activities with and/or near computerized systems. Fortunately, some researchers specialize in helping warfighters via gaming or virtual reality technologies. Nevertheless, a dearth of literature is published about challenges researchers face when conducting these types of studies. This article shares the experiences of a research team, under a uniformed Army Research Psychologist (Stetz), who runs research studies (a) with warfighters, (b) with technological equipment, and (c) in nonstandard laboratory settings. C1 [Stetz, Melba C.; Makela, Anna; Folen, Ray] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Wiederhold, Brenda K.] Virtual Real Med Ctr, San Diego, CA USA. RP Stetz, MC (reprint author), Tripler Army Med Ctr, Dept Psychol, 1 Jarrett White Rd, Tripler, HI 96859 USA. EM melba.stetz@us.army.mil NR 19 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 2152-2715 J9 CYBERPSYCH BEH SOC N JI Cyberpsychology Behav. Soc. Netw. PD FEB PY 2010 VL 13 IS 1 BP 79 EP 82 DI 10.1089/cyber.2009.0328 PG 4 WC Psychology, Social SC Psychology GA 601BZ UT WOS:000278034300012 PM 20528297 ER PT J AU Engel, RC Gallagher, LB Lyle, DS AF Engel, Rozlyn C. Gallagher, Luke B. Lyle, David S. TI Military deployments and children's academic achievement: Evidence from Department of Defense Education Activity Schools SO ECONOMICS OF EDUCATION REVIEW LA English DT Article DE Human capital ID ABSENCES AB Household disruptions - such as divorce, relocation, and parental absence - have long concerned researchers interested in the educational attainment of children. Here, we consider a plausible source of exogenous variation in work-related parental absences-military deployments to Iraq and Afghanistan in the 2002-2005 period. Combining the standardized test scores of children enrolled in Defense Department schools with their military parent's personnel data, we evaluate the effect of a soldier's deployment on the academic achievement of his or her children. We find that deployments have modest adverse effects in most academic subjects, with lengthy deployments and deployments during the month of testing associated with the largest detrimental effects. Evidence also suggests that these adverse effects may persist for several years. Published by Elsevier Ltd. All rights reserved. C1 [Engel, Rozlyn C.; Gallagher, Luke B.; Lyle, David S.] US Mil Acad, Dept Social Sci, West Point, NY 10996 USA. RP Engel, RC (reprint author), US Mil Acad, Dept Social Sci, Lincoln Hall, West Point, NY 10996 USA. EM rozlyn.engel@usma.edu NR 6 TC 26 Z9 26 U1 2 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0272-7757 J9 ECON EDUC REV JI Econ. Educ. Rev. PD FEB PY 2010 VL 29 IS 1 BP 73 EP 82 DI 10.1016/j.econedurev.2008.12.003 PG 10 WC Economics; Education & Educational Research SC Business & Economics; Education & Educational Research GA 560BX UT WOS:000274877900006 ER PT J AU Jones, LE Norris, WE AF Jones, L. E. Norris, W. E. TI Rectal burn induced by hot coffee enema SO ENDOSCOPY LA English DT Editorial Material C1 [Jones, L. E.] Natl Naval Med Ctr, Dept Gastroenterol, Bethesda, MD 20889 USA. [Norris, W. E.] Walter Reed Army Med Ctr, Gastroenterol Serv, Washington, DC 20307 USA. RP Jones, LE (reprint author), Natl Naval Med Ctr, Dept Gastroenterol, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM lindsay.jones2@med.navy.mil NR 2 TC 3 Z9 4 U1 0 U2 1 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0013-726X J9 ENDOSCOPY JI Endoscopy PD FEB PY 2010 VL 42 SU 2 BP E26 EP E26 DI 10.1055/s-0029-1215312 PG 1 WC Gastroenterology & Hepatology; Surgery SC Gastroenterology & Hepatology; Surgery GA 555EE UT WOS:000274490000015 PM 20073005 ER PT J AU Grim, CJ Jaiani, E Whitehouse, CA Janelidze, N Kokashvili, T Tediashvili, M Colwell, RR Huq, A AF Grim, Christopher J. Jaiani, Ekaterina Whitehouse, Chris A. Janelidze, Nino Kokashvili, Tamuna Tediashvili, Marina Colwell, Rita R. Huq, Anwar TI Detection of toxigenic Vibrio cholerae O1 in freshwater lakes of the former Soviet Republic of Georgia SO ENVIRONMENTAL MICROBIOLOGY REPORTS LA English DT Review ID MONOCLONAL ANTIBODY; AQUATIC ENVIRONMENT; BANGLADESH AB Three freshwater lakes, Lisi Lake, Kumisi Lake and Tbilisi Sea, near Tbilisi, Georgia, were studied from January 2006 to December 2007 to determine the presence of Vibrio cholerae employing both bacteriological culture method and direct detection methods, namely PCR and direct fluorescent antibody (DFA). For PCR, DNA extracted from water samples was tested for presence of V. cholerae and genes coding for selected virulence factors. Vibrio cholerae non-O1/non-O139 was routinely isolated by culture from all three lakes; whereas V. cholerae O1 and O139 were not. Water samples collected during the summer months from Lisi Lake and Kumisi Lake were positive for both V. cholerae and V. cholerae ctxA, tcpA, zot, ompU and toxR by PCR. Water samples collected during the same period from both Lisi and Kumisi Lake were also positive for V. cholerae serogroup O1 by DFA. All of the samples were negative for V. cholerae serotype O139. The results of this study provide evidence for an environmental presence of toxigenic V. cholerae O1, which may represent a potential source of illness as these lakes serve as recreational water in Tbilisi, Georgia. C1 [Grim, Christopher J.; Colwell, Rita R.; Huq, Anwar] Univ Maryland, Maryland Pathogen Res Inst, College Pk, MD 20742 USA. [Grim, Christopher J.; Colwell, Rita R.] Univ Maryland, Inst Adv Comp Studies, College Pk, MD 20742 USA. [Jaiani, Ekaterina; Janelidze, Nino; Kokashvili, Tamuna; Tediashvili, Marina] G Eliava Inst Bacteriophage Microbiol & Virol, Tbilisi, Rep of Georgia. [Whitehouse, Chris A.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Huq, A (reprint author), Univ Maryland, Maryland Pathogen Res Inst, College Pk, MD 20742 USA. EM huq@umd.edu FU US Defense Threat Reduction Agency (DTRA) [GG-13]; NGA [HM15820612010] FX The research was supported by the US Defense Threat Reduction Agency (DTRA) CBR grant GG-13 and C.J.G. was supported by an IC Postdoctoral Research Fellowship (NGA Grant #HM15820612010). NR 20 TC 5 Z9 5 U1 0 U2 5 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1758-2229 J9 ENV MICROBIOL REP JI Environ. Microbiol. Rep. PD FEB PY 2010 VL 2 IS 1 SI SI BP 2 EP 6 DI 10.1111/j.1758-2229.2009.00073.x PG 5 WC Environmental Sciences; Microbiology SC Environmental Sciences & Ecology; Microbiology GA 619LO UT WOS:000279431900001 PM 23765992 ER PT J AU Stanley, JK Coleman, JG Weiss, CA Steevens, JA AF Stanley, Jacob K. Coleman, Jessica G. Weiss, Charles A., Jr. Steevens, Jeffery A. TI SEDIMENT TOXICITY AND BIOACCUMULATION OF NANO AND MICRON-SIZED ALUMINUM OXIDE SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Nano; Aluminum oxide; Sediment; Toxicity; Bioaccumulation ID HYALELLA-AZTECA; WATER; NANOPARTICLES; NANOMATERIALS AB Nano-aluminum oxide (Al(2)O(3)) is used commercially in coatings and abrasives. Nano-Al(2)O(3) can also be generated through the oxidation of nano-aluminum in military propellants and energetics. The purpose of the present study was to assess toxicity and bioaccumulation of nano-Al(2)O(3) to a variety of sediment organisms (Tubifex tubifex, Hyalella azteca, Lumbriculus variegatus, and Corbicula fluminea). The bioaccumulation and toxicity of nano-Al(2)O(3) was compared with that of micron-sized Al(2)O(3) to investigate potential size-related effects. Results of the present study show species-specific differences in relative bioaccumulation of nano- and micron-sized Al(2)O(3). Significant toxic effects (survival and growth) were observed in H. azteca testing, but only at high concentrations unlikely to be found in the environment. Nano-Al(2)O(3) was found to be more toxic than micron-sized Al(2)O(3) to H. azteca survival in a 14-d study in which organisms were in direct contact with a thin layer of 625 or 2,500 mg of Al(2)O(3) dispersed on the surface of either sediment or sand. A significant growth effect was also observed for nano but not micron-sized Al(2)O(3) at the highest treatment level tested (100 g/kg Al(2)O(3)) in a 10-d H. azteca bioassay in which Al(2)O(3) was homogenized with sediment. However, differences in measured sediment Al concentrations (micron-sized = 55.1 [+/- 0.61 g/kg Al; nano-sized = 66.2 [+/- 0.6] g/kg Al) in the nano and micron-sized Al(2)O(3) preclude direct comparison of the toxicity of these two treatments based on particle size. Environ. Toxicol. Chem. 2010;29:422-429. (C) 2009 SETAC C1 [Stanley, Jacob K.; Coleman, Jessica G.; Steevens, Jeffery A.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Weiss, Charles A., Jr.] USA, Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. RP Stanley, JK (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM jacob.k.stanley@us.army.mil FU U.S. Army's Environmental Quality Technology Basic Research Program FX Permission to publish this material was granted by the Chief of Engineers. This work was supported by the U.S. Army's Environmental Quality Technology Basic Research Program (John Cullinane, Technical Director). The authors thank Jennifer Bouldin and Jaimie Conrad of Arkansas State University for collecting the C. fluminea used in the clam bioaccumulation bioassay. We also thank Jamma Williams and Jenny Goss of the U.S. Army Engineer Research and Development Center for technical laboratory support. NR 21 TC 20 Z9 26 U1 1 U2 50 PU SETAC PRESS PI PENSACOLA PA 1010 N 12TH AVE, PENSACOLA, FL 32501-3367 USA SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD FEB PY 2010 VL 29 IS 2 BP 422 EP 429 DI 10.1002/etc.52 PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 552FB UT WOS:000274272500023 PM 20821462 ER PT J AU Liu, MC Akinyi, L Scharf, D Mo, JX Larner, SF Muller, U Oli, MW Zheng, WR Kobeissy, F Papa, L Lu, XC Dave, JR Tortella, FC Hayes, RL Wang, KKW AF Liu, Ming C. Akinyi, Linnet Scharf, Dancia Mo, Jixiang Larner, Stephen F. Muller, Uwe Oli, Monika W. Zheng, Wenrong Kobeissy, Firas Papa, Linda Lu, Xi-Chun Dave, Jitendra R. Tortella, Frank C. Hayes, Ronald L. Wang, Kevin K. W. TI Ubiquitin C-terminal hydrolase-L1 as a biomarker for ischemic and traumatic brain injury in rats SO EUROPEAN JOURNAL OF NEUROSCIENCE LA English DT Article DE biomarker; cell death; ischemia; diagnosis; stroke; traumatic brain injury ID NEURON-SPECIFIC ENOLASE; ALPHA-II-SPECTRIN; FIBRILLARY ACIDIC PROTEIN; SEVERE HEAD-INJURY; CEREBROSPINAL-FLUID; SURROGATE MARKERS; DEUBIQUITINATING ENZYMES; OUTCOME PREDICTION; BREAKDOWN PRODUCTS; SERUM BIOMARKER AB Ubiquitin C-terminal hydrolase-L1 (UCH-L1), also called neuronal-specific protein gene product 9.5, is a highly abundant protein in the neuronal cell body and has been identified as a possible biomarker on the basis of a recent proteomic study. In this study, we examined whether UCH-L1 was significantly elevated in cerebrospinal fluid (CSF) following controlled cortical impact (CCI) and middle cerebral artery occlusion (MCAO; model of ischemic stroke) in rats. Quantitative immunoblots of rat CSF revealed a dramatic elevation of UCH-L1 protein 48 h after severe CCI and as early as 6 h after mild (30 min) and severe (2 h) MCAO. A sandwich enzyme-linked immunosorbent assay constructed to measure UCH-L1 sensitively and quantitatively showed that CSF UCH-L1 levels were significantly elevated as early as 2 h and up to 48 h after CCI. Similarly, UCH-L1 levels were also significantly elevated in CSF from 6 to 72 h after 30 min of MCAO and from 6 to 120 h after 2 h of MCAO. These data are comparable to the profile of the calpain-produced alpha II-spectrin breakdown product of 145 kDa biomarker. Importantly, serum UCH-L1 biomarker levels were also significantly elevated after CCI. Similarly, serum UCH-L1 levels in the 2-h MCAO group were significantly higher than those in the 30-min group. Taken together, these data from two rat models of acute brain injury strongly suggest that UCH-L1 is a candidate brain injury biomarker detectable in biofluid compartments (CSF and serum). C1 [Liu, Ming C.; Larner, Stephen F.; Zheng, Wenrong; Hayes, Ronald L.; Wang, Kevin K. W.] Banyan Biomarkers Inc, Ctr Innovat Res, Alachua, FL 32615 USA. [Akinyi, Linnet; Scharf, Dancia; Mo, Jixiang; Muller, Uwe; Oli, Monika W.; Hayes, Ronald L.; Wang, Kevin K. W.] Banyan Biomarkers Inc, Diagnost Res & Dev Dept, Alachua, FL 32615 USA. [Kobeissy, Firas; Wang, Kevin K. W.] Univ Florida, Dept Psychiat, McKnight Brain Inst, Ctr Neuroprote & Biomarkers Res, Gainesville, FL 32611 USA. [Papa, Linda] Orlando Reg Med Ctr Inc, Dept Emergency Med, Orlando, FL USA. [Lu, Xi-Chun; Dave, Jitendra R.; Tortella, Frank C.] Walter Reed Army Inst Res, Dept Appl Neurobiol, Div Psychiat & Neurosci, Silver Spring, MD USA. [Hayes, Ronald L.] Univ Florida, Dept Anesthesiol, Gainesville, FL USA. [Wang, Kevin K. W.] Taipei Med Univ, Taipei, Taiwan. RP Wang, KKW (reprint author), Banyan Biomarkers Inc, Ctr Innovat Res, 12085 Res Dr, Alachua, FL 32615 USA. EM kwang@banyanbio.com RI kobeissy, firas/E-7042-2017; OI kobeissy, firas/0000-0002-5008-6944; Wang, Kevin/0000-0002-9343-6473 FU Department of Defense [DAMD17-03-1-0066]; NIH [R01 NS049175-01 A1, 2R44NS048685-02]; Florida State Center for Nano-Bio Sensors (CNBS) grant FX The authors would like to acknowledge the support of Department of Defense grant DAMD17-03-1-0066 (R. L. Hayes), NIH grants R01 NS049175-01 A1 (K. Wang) and 2R44NS048685-02 (K. K. Wang), and a Florida State Center for Nano-Bio Sensors (CNBS) grant (K. K. Wang). This article has been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the true views of the Department of the Army or the Department of Defense. Research was conducted in compliance with the Animal Welfare Act and other federal statutes and regulations relating to animals and experiments involving animals, and adheres to principles stated in the Guide for the Care and Use of Laboratory Animals, NRC Publication, 1996 edition. K. K. Wang and R. L. Hayes hold equity in Banyan Biomarkers, Inc., a company that commercializes technology for detecting brain injury biomarkers. NR 65 TC 54 Z9 58 U1 0 U2 12 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0953-816X J9 EUR J NEUROSCI JI Eur. J. Neurosci. PD FEB PY 2010 VL 31 IS 4 BP 722 EP 732 DI 10.1111/j.1460-9568.2010.07097.x PG 11 WC Neurosciences SC Neurosciences & Neurology GA 555XH UT WOS:000274549500013 PM 20384815 ER PT J AU Cole, DM Mathisen, LU Hopkins, MA Knapp, BR AF Cole, David M. Mathisen, Lillian Uthus Hopkins, M. A. Knapp, Byron R. TI Normal and sliding contact experiments on gneiss SO GRANULAR MATTER LA English DT Article DE Contact mechanics; Contact stiffness; Gneiss; Experiments; Micromechanics ID MECHANICS AB The development of reliable discrete element models to simulate the mechanics of granular media requires knowledge of the grain-to-grain contact laws of the material in question. We have conducted a series of normal and sliding contact experiments on material used in laboratory triaxial experiments to obtain such contact laws for DEM simulations of the experiments. The contact experiments employed segments of 14.72 mm-diameter spherical grains from the triaxial specimens and flat specimens of the same material. The spherical grains had a uniform diameter with a smooth surface finish. Monotonic and cyclic loading paths were applied in both the normal and sliding modes, and both sphere-sphere and sphere-flat contact behavior were examined. Force-displacement behavior and frictional loss were measured in all cases. The behavior was generally Hertzian in the normal contact experiments, which involved forces up to approximately 100 N. The normal contact stiffness increased from a parts per thousand 2 to 15MN m(-1) over the range of normal force examined. The sliding experiments employed several normal forces up to approximately 25 N, and produced a value of the coefficient of static friction of 0.28. The shear stiffness of the sliding contact increased with normal force, and ranged from 0.8 to 1.2MN m(-1) under normal loads ranging from a parts per thousand 1 to 7.5 N, respectively, for virgin contacts. The shear stiffness observed for the sphere-flat contact decreased with wear. Surface roughness measurements were obtained on both tested and untested regions of the spheres and flat specimens. The average roughness (Ra) for untested regions of the sphere and flat specimens were 270 and 230 nm, respectively. Repeated testing in the sliding mode reduced these values by 29-45% for the flat surfaces, and by 20% for the spherical contact. Frictional losses were observed in both the normal and sliding modes. In the sliding mode, frictional loss decreased with increasing normal load. We observed stable sliding (associated with significant contact movement under an increasing shear force) at forces that were below the macroscopic frictional limit and resulted in permanent displacement of the contact. There was generally a distinct threshold in shear force for this permanent sliding. The extent of sliding increased significantly with wear for the sphere-flat contact and was accompanied by a substantial drop in shear stiffness. C1 [Cole, David M.; Hopkins, M. A.] USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. [Mathisen, Lillian Uthus] Kolo Veidekke AS, N-7435 Trondheim, Norway. [Knapp, Byron R.] Profess Instruments Co, Hopkins, MN 55343 USA. RP Cole, DM (reprint author), USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. EM David.M.Cole@usace.army.mil; Lillian.Uthus.Mathisen@veidekke.no FU Norwegian GARAP; Norwegian Public Road Administration; Norwegian Rail Administration; Norwegian Research Council; Norwegian Aggregate Producers Association; Avinor; Nynas FX Basic Research Grant entitled, "Variable-sized Ellipsoidal Discrete Element Model of Soil Mechanical Behavior". The production cost of the aggregate spheres was supported by the six participants of the Norwegian GARAP (Granular Aggregates in Road and Airfield Pavements) project: Norwegian Public Road Administration; Norwegian Rail Administration; Norwegian Research Council; Norwegian Aggregate Producers Association; Avinor; Nynas. We express our appreciation to Chris Williams, Bill Burch and John Gagnon of ERDC-CRREL for their valuable contributions to the development of the equipment and control software that made these experiments possible. NR 19 TC 10 Z9 10 U1 2 U2 16 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1434-5021 EI 1434-7636 J9 GRANUL MATTER JI Granul. Matter PD FEB PY 2010 VL 12 IS 1 BP 69 EP 86 DI 10.1007/s10035-010-0165-z PG 18 WC Materials Science, Multidisciplinary; Mechanics; Physics, Applied SC Materials Science; Mechanics; Physics GA 555VX UT WOS:000274545500005 ER PT J AU Harrison, SA AF Harrison, Stephen A. TI Thiazolidinedione Therapy for Nonalcoholic Steatohepatitis: Go, Stop, or Proceed with Caution? SO HEPATOLOGY LA English DT Editorial Material ID RANDOMIZED CONTROLLED-TRIAL; PLACEBO-CONTROLLED TRIAL; FATTY LIVER-DISEASE; METABOLIC SYNDROME; BARIATRIC SURGERY; FOLLOW-UP; PIOGLITAZONE; ROSIGLITAZONE; RISK; ADIPONECTIN C1 Brooke Army Med Ctr, Dept Gastroenterol, Div Gastroenterol & Hepatol, Ft Sam Houston, TX 78234 USA. RP Harrison, SA (reprint author), Brooke Army Med Ctr, Dept Gastroenterol, Div Gastroenterol & Hepatol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM stephen.harrison@amedd.army.mil NR 24 TC 8 Z9 8 U1 0 U2 1 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD FEB PY 2010 VL 51 IS 2 BP 366 EP 369 DI 10.1002/hep.23473 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 550ME UT WOS:000274131200002 PM 20101743 ER PT J AU Theiling, CH Nestler, JM AF Theiling, Charles H. Nestler, John M. TI River stage response to alteration of Upper Mississippi River channels, floodplains, and watersheds SO HYDROBIOLOGIA LA English DT Article; Proceedings Paper CT 40th Annual Meeting of the Mississippi-River-Research-Consortium CY APR 24-25, 2008 CL Dubuque, IA SP Mississippi River Res Consortium DE Hydrologic indicators; Predictability; Multivariate analysis; Impact analysis; Floodplain river ID HYDROLOGIC ALTERATION; MISSOURI RIVER; ILLINOIS RIVER; FLOOD; ECOSYSTEMS; PREDICTABILITY; STREAMFLOW; PATTERNS; HISTORY; SYSTEM AB The Upper Mississippi River System (UMRS) is a large and diverse river system that changes character along its 1,200 mile network of rivers and canals and 2.6 million acres of floodplain. It supports more than 30 million people in its watershed, a significant commercial waterway, more than a million acres of "floodplain" agriculture and about one-half million acres of river-floodplain managed for fish, wildlife, and recreation. Large-scale geomorphology and climate patterns largely determine the hydrologic characteristics of a nested hierarchy of UMRS river reaches. The human impacts above are also important drivers determining hydrologic characteristics within the hierarchy. Understanding the relationship among physical and chemical processes and ecological responses is critical to implement an adaptive management framework for UMRS ecosystem sustainability. Historic or contemporary data from 42 locations were used to examine changes in UMRS hydrology and to demonstrate the utility of a multiple reference condition analysis for river restoration. A multivariate mathematical framework was used to show how river stage hydrology can be characterized by the variability, predictability, seasonality, and rate of change. Large-scale "geomorphic reaches" have distinct hydrologic characteristics and response to development throughout the UMRS region, but within navigation pool hydrology is similar among all impounded reaches regardless of geomorphic reach. Reaches with hydrologic characteristics similar to historic reference conditions should be examined to determine whether those characteristics support desired management objectives. Water levels can be managed, within limits to support navigation and agriculture, to more closely resemble natural hydrology for the benefit of a variety of species, habitats, and ecological processes. C1 [Theiling, Charles H.] USA, Corps Engineers, Rock Isl, IL 61204 USA. [Nestler, John M.] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Theiling, CH (reprint author), USA, Corps Engineers, Clock Tower Bldg,POB 2004, Rock Isl, IL 61204 USA. EM charles.h.theiling@usace.army.mil; john.m.nestler@usace.army.mil NR 94 TC 7 Z9 7 U1 3 U2 25 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0018-8158 J9 HYDROBIOLOGIA JI Hydrobiologia PD FEB PY 2010 VL 640 IS 1 BP 17 EP 47 DI 10.1007/s10750-009-0066-5 PG 31 WC Marine & Freshwater Biology SC Marine & Freshwater Biology GA 546KR UT WOS:000273810200003 ER PT J AU Torrieri, D Valenti, MC AF Torrieri, Don Valenti, Matthew C. TI Efficiently Decoded Full-Rate Space-Time Block Codes SO IEEE TRANSACTIONS ON COMMUNICATIONS LA English DT Article DE Space-time block codes; genetic algorithm; diversity; quasi-orthogonal codes ID QUASI-ORTHOGONAL STBC; PERFORMANCE ANALYSIS; COMPLEXITY; DIVERSITY AB Space-time block codes with orthogonal structures typically provide full-diversity reception and simple receiver processing. However, rate-1 orthogonal codes for complex constellations have not been found for more than two transmit antennas. By using a genetic algorithm, rate-1 space-time block codes that accommodate very simple receiver processing at the cost of reduced diversity are designed in this paper for more than two transmit antennas. Simulation results show that evolved codes combined with efficient outer codes provide better performance over fading channels than minimum-decoding-complexity quasi-orthogonal codes at typical operating signal-to-noise ratios. When the fading is more severe than Rayleigh fading, the spectral efficiency is specified, and an efficient outer code is used, evolved codes outperform orthogonal space-time block codes. C1 [Torrieri, Don] USA, Res Lab, Adelphi, MD USA. [Valenti, Matthew C.] W Virginia Univ, Morgantown, WV 26506 USA. RP Torrieri, D (reprint author), USA, Res Lab, Adelphi, MD USA. EM dtorr@arl.army.mil; mvalenti@wvu.edu OI Valenti, Matthew/0000-0001-6089-0509 NR 19 TC 5 Z9 5 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0090-6778 J9 IEEE T COMMUN JI IEEE Trans. Commun. PD FEB PY 2010 VL 58 IS 2 BP 480 EP 488 DI 10.1109/TCOMM.2010.02.090003 PG 9 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 578XP UT WOS:000276330800019 ER PT J AU Dutta, S Dlugosz, LS Clayton, JW Pool, CD Haynes, JD Gasser, RA Batchelor, AH AF Dutta, Sheetij Dlugosz, Lisa S. Clayton, Joshua W. Pool, Christopher D. Haynes, J. David Gasser, Robert A., III Batchelor, Adrian H. TI Alanine Mutagenesis of the Primary Antigenic Escape Residue Cluster, C1, of Apical Membrane Antigen 1 SO INFECTION AND IMMUNITY LA English DT Article ID MALARIA VACCINE CANDIDATE; PLASMODIUM-FALCIPARUM; ANTIBODY-RESPONSE; INHIBITORY ANTIBODY; IMMUNOGENICITY; INVASION; AMA-1; EPITOPE; GROWTH; TRIAL AB Antibodies against apical membrane antigen 1 (AMA1) inhibit invasion of Plasmodium merozoites into red cells, and a large number of single nucleotide polymorphisms on AMA1 allow the parasite to escape inhibitory antibodies. The availability of a crystal structure makes it possible to test protein engineering strategies to develop a monovalent broadly reactive vaccine. Previously, we showed that a linear stretch of polymorphic residues (amino acids 187 to 207), localized within the C1 cluster on domain 1, conferred the highest level of escape from inhibitory antibodies, and these were termed antigenic escape residues (AER). Here we test the hypothesis that immunodampening the C1 AER will divert the immune system toward more conserved regions. We substituted seven C1 AER of the FVO strain Plasmodium falciparum AMA1 with alanine residues (ALA). The resulting ALA protein was less immunogenic than the native protein in rabbits. Anti-ALA antibodies contained a higher proportion of cross-reactive domain 2 and domain 3 antibodies and had higher avidity than anti-FVO. No overall enhancement of cross-reactive inhibitory activity was observed when anti-FVO and anti-ALA sera were compared for their ability to inhibit invasion. Alanine mutations at the C1 AER had shifted the immune response toward cross-strain-reactive epitopes that were noninhibitory, refuting the hypothesis but confirming the importance of the C1 cluster as an inhibitory epitope. We further demonstrate that naturally occurring polymorphisms that fall within the C1 cluster can predict escape from cross-strain invasion inhibition, reinforcing the importance of the C1 cluster genotype for antigenic categorization and allelic shift analyses in future phase 2b trials. C1 [Dutta, Sheetij; Dlugosz, Lisa S.; Clayton, Joshua W.; Pool, Christopher D.; Haynes, J. David; Gasser, Robert A., III; Batchelor, Adrian H.] Walter Reed Army Inst Res, Dept Epitope Mapping, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. RP Dutta, S (reprint author), Walter Reed Army Inst Res, Dept Epitope Mapping, Div Malaria Vaccine Dev, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Sheetij.dutta@us.army.mil FU United States Agency for International Development; Malaria Vaccine Initiative FX Funding for this work was provided by the Malaria Vaccine Development Program grant (2008) from the United States Agency for International Development and a grant from the Malaria Vaccine Initiative (2009). NR 33 TC 12 Z9 12 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD FEB PY 2010 VL 78 IS 2 BP 661 EP 671 DI 10.1128/IAI.00866-09 PG 11 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 546ZY UT WOS:000273855600011 PM 19948834 ER PT J AU Dabisch, PA Kline, J Lewis, C Yeager, J Pitt, MLM AF Dabisch, P. A. Kline, J. Lewis, C. Yeager, J. Pitt, M. L. M. TI Characterization of a head-only aerosol exposure system for nonhuman primates SO INHALATION TOXICOLOGY LA English DT Article AB A well-characterized exposure chamber is necessary to generate reproducible atmospheres for inhalation toxicology studies. The aim of the present study was to characterize a head-only exposure chamber for non-human primates. Aerosols containing bovine serum albumin (BSA) were used to characterize a 16-L dynamic airflow head-only exposure chamber. A 250-ml plastic bottle with a respirator attached located inside the chamber was used to simulate a breathing head. Chamber leak rate, mixing, and aerosol spatial distributions were quantified. The chamber concentration profile was measured at the chamber exhaust using an aerodynamic particle sizer. Aerosol spatial distribution was determined by collecting filter samples at several chamber locations. The particle size distribution was determined by collecting cascade impactor samples at several chamber locations. The estimated chamber leak rate was within standards suggested in the literature. The measured average aerosol residence time was similar to theoretical aerosol residence time, suggesting that the chamber was mixing well. Additionally, the average concentration measured at each of the sampling locations within the chamber was similar, and the within-run coefficients of variation (CV) across all sampling locations was similar to those reported in previously published studies, again suggesting that the aerosol concentration throughout the chamber was uniform. The particle size distribution was similar throughout the exposure chamber. Additionally, the BSA concentration and particle size distributions measured in the breathing zone of the simulated head were not significantly different from measurements made elsewhere in the chamber, suggesting that respiration does not affect the average aerosol concentration or particle size distribution at the mouth.