FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Celmins, I AF Celmins, I. BE Baker, E Templeton, D TI 5.56 mm M855 ACCURACY AND JUMP MEASUREMENTS SO BALLISTICS 2011: 26TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOL 1 AND VOL 2 LA English DT Proceedings Paper CT 26th International Symposium on Ballistics CY SEP 12-16, 2011 CL Miami, FL SP Ballist Div Natl Def Ind Assoc (NDIA) AB A jump test and analysis was performed to evaluate the accuracy of the 5.56mm M855 projectile when fired from the M4 weapon system, and from a Mann barrel for comparison. The magnitudes of the CG jump and aerodynamic jump components were significantly larger than the muzzle motion components. The performance from two different standard barrels was similar. Removal of the compensator resulted in slightly increased muzzle motion, which can be attributed to removal of mass from the muzzle. The Mann barrel exhibited drastically reduced muzzle motion. The largest dispersion contributors for all configurations were the relative CG jump and the aerodynamic jump and strong interactions were identified between these components. The overall effect of the compensator was positive, in that it resulted in lower total jump dispersion due to strengthened negative correlations. For the Mann barrel, there was a decrease in magnitude and dispersion of all jump components. C1 USA, Res Lab, RDRL WML E, Aberdeen Proving Ground, MD 21005 USA. RP Celmins, I (reprint author), USA, Res Lab, RDRL WML E, Aberdeen Proving Ground, MD 21005 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-052-5 PY 2011 BP 987 EP 998 PG 12 WC Engineering, Multidisciplinary; Mechanics SC Engineering; Mechanics GA BXY64 UT WOS:000297632200105 ER PT J AU Minnicino, M AF Minnicino, M. BE Baker, E Templeton, D TI INFLUENCE OF MATERIAL PROPERTIES ON SABOT DESIGN SO BALLISTICS 2011: 26TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOL 1 AND VOL 2 LA English DT Proceedings Paper CT 26th International Symposium on Ballistics CY SEP 12-16, 2011 CL Miami, FL SP Ballist Div Natl Def Ind Assoc (NDIA) AB The mass of a sabot is its ultimate measure of its performance. The sabot is parasitic and therefore great effort is made to minimize its mass. This paper parametrically investigates the influence of material properties on the sabot design to identify paths of improvement. The mass of the rear sabot ramp is used to evaluate potential sabot material substitutes. The study indicates that low density materials are significantly more efficient sabot materials than high stiffness materials for a given specific stiffness. Additionally, the significance of the sabot material's strength is evaluated and its effect on the sabot's mass is quantified. It is found that the sabot material's strength has a decreasing significance as the materials specific stiffness increases. C1 USA, Weap & Mat Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Minnicino, M (reprint author), USA, Weap & Mat Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 3 TC 0 Z9 0 U1 2 U2 5 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-052-5 PY 2011 BP 1006 EP 1014 PG 9 WC Engineering, Multidisciplinary; Mechanics SC Engineering; Mechanics GA BXY64 UT WOS:000297632200107 ER PT J AU Jones, TL Kondoh, K AF Jones, T. L. Kondoh, K. BE Baker, E Templeton, D TI BALLISTIC ANALYSIS OF NEW MILITARY GRADE MAGNESIUM ALLOYS FOR ARMOR APPLICATIONS SO BALLISTICS 2011: 26TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOL 1 AND VOL 2 LA English DT Proceedings Paper CT 26th International Symposium on Ballistics CY SEP 12-16, 2011 CL Miami, FL SP Ballist Div Natl Def Ind Assoc (NDIA) AB Since 2006, the U.S. Army has been evaluating magnesium (Mg) alloys for ballistic structural applications. While Mg-alloys have been used in military structural applications since WWII, very little research has been done to improve their mediocre ballistic performance. The Army's need for ultra-lightweight armor systems has led to research and development of high strength, high ductility Mg-alloys. The U.S. Army Research Laboratory contracted through international Technology Center-Pacific Contract Number FA-5209-09-P-0158 with the Joining and Welding Research Institute of Osaka University to develop the next generation of high strength, high ductility Mg-alloys using a novel Spinning Water Atomization Process for rapid solidification. New alloys AMX602 and ZAXE1711 in extruded bar form were characterized for microstructure, mechanical, and ballistic response. Significant increases in ballistic performance were evident when compared to the baseline alloy AZ31B. C1 [Jones, T. L.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Jones, TL (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 12 TC 0 Z9 0 U1 1 U2 6 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-052-5 PY 2011 BP 1091 EP 1099 PG 9 WC Engineering, Multidisciplinary; Mechanics SC Engineering; Mechanics GA BXY64 UT WOS:000297632200115 ER PT J AU Schraml, SJ AF Schraml, S. J. BE Baker, E Templeton, D TI SENSITIVITY OF JOHNSON-COOK CONSTITUTIVE MODEL PARAMETERS IN MODELING PENETRATION OF ROLLED HOMOGENEOUS ARMOR STEEL TARGETS BY TUNGSTEN RODS SO BALLISTICS 2011: 26TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOL 1 AND VOL 2 LA English DT Proceedings Paper CT 26th International Symposium on Ballistics CY SEP 12-16, 2011 CL Miami, FL SP Ballist Div Natl Def Ind Assoc (NDIA) AB A computational parametric study was performed to assess the influence of the selection of Johnson-Cook constitutive model parameters on the numerical simulation of tungsten rods penetrating rolled homogeneous armor (RHA) steel targets. The parameter space involved two sets of Johnson-Cook model parameters for RHA, two sets of Johnson-Cook parameters for the tungsten rod material, four tungsten rod length-to-diameter (L/D) ratios, and two continuum mechanics codes. velocities considered in the study ranged from approximately 1000 - 2000 m/s. The study revealed that no single combination of Johnson-Cook model parameters provides superior overall prediction of penetration depth over the other possible combinations across the full range of rod L/D considered. The study provides valuable guidance on the selection of material model parameters future studies of kinetic energy penetration. C1 USA, Res Lab, RDRL WML H, Aberdeen Proving Ground, MD 21005 USA. RP Schraml, SJ (reprint author), USA, Res Lab, RDRL WML H, Aberdeen Proving Ground, MD 21005 USA. NR 14 TC 0 Z9 0 U1 2 U2 3 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-052-5 PY 2011 BP 1133 EP 1143 PG 11 WC Engineering, Multidisciplinary; Mechanics SC Engineering; Mechanics GA BXY64 UT WOS:000297632200120 ER PT J AU Meyer, CS AF Meyer, C. S. BE Baker, E Templeton, D TI DEVELOPMENT OF BRICK AND MORTAR MATERIAL PARAMETERS FOR NUMERICAL SIMULATIONS USING THE HOLMQUIST-JOHNSON-COOK CONSTITUTIVE MODEL FOR CONCRETE SO BALLISTICS 2011: 26TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOL 1 AND VOL 2 LA English DT Proceedings Paper CT 26th International Symposium on Ballistics CY SEP 12-16, 2011 CL Miami, FL SP Ballist Div Natl Def Ind Assoc (NDIA) ID MASONRY AB Numerical simulation of brick and mortar masonry in the literature has been performed using homogenized material properties; however, heterogeneous material properties for brick and mortar for a constitutive model built into hydrocodes have been unavailable. The Holmquist-Johnson-Cook (HJC) constitutive model for concrete captures pressure and strain-rate dependent strength behavior and void crushing damage behavior of porous materials reasonably well, is readily available in many hydrocodes, and is commonly used to simulate high-velocity penetration of concrete. This paper describes the development of the brick and mortar material parameters for the HJC material model-including exploration of the materials' strength, damage, and pressure behavior-from available static and dynamic test data, and the paper provides the HJC model material parameters for brick and mortar. The paper also presents sample numerical simulations, using the material parameters developed, and compares the resulting material behavior to mechanical test data. C1 USA, Res Lab, RDRL WML H, Aberdeen Proving Ground, MD 21005 USA. RP Meyer, CS (reprint author), USA, Res Lab, RDRL WML H, Aberdeen Proving Ground, MD 21005 USA. NR 14 TC 0 Z9 0 U1 1 U2 7 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-052-5 PY 2011 BP 1208 EP 1219 PG 12 WC Engineering, Multidisciplinary; Mechanics SC Engineering; Mechanics GA BXY64 UT WOS:000297632200127 ER PT J AU Gallardy, D AF Gallardy, D. BE Baker, E Templeton, D TI BALLISTIC EVALUATION OF ALUMINUM 7085-T7E01 AND T7E02 SO BALLISTICS 2011: 26TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOL 1 AND VOL 2 LA English DT Proceedings Paper CT 26th International Symposium on Ballistics CY SEP 12-16, 2011 CL Miami, FL SP Ballist Div Natl Def Ind Assoc (NDIA) AB The U.S. Army Research Laboratory set out to evaluate a high strength 7XXX series aluminum alloy that is commercially available and performs equal to or better than the existing 7XXX series armor alloy, AA7039-T64 per MIL-DTL-46063. This paper will present the results of the ballistic evaluation of AA7085 in both the T7E01 and T7E02 tempers. The T7E01 temper was designed for armor piercing applications whereas the T7E02 temper was designed for blast application. Details from V50 ballistic testing using armor piercing (AP) and fragment simulating projectiles (FSPs) will be discussed and a comparison with the established military specification AA7039 will be made. The test results will be used to develop a new military specification for AA7085 based on its performance. C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Gallardy, D (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 6 TC 1 Z9 1 U1 0 U2 1 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-052-5 PY 2011 BP 1357 EP 1363 PG 7 WC Engineering, Multidisciplinary; Mechanics SC Engineering; Mechanics GA BXY64 UT WOS:000297632200145 ER PT J AU Fountzoulas, CG Sands, JM AF Fountzoulas, C. G. Sands, J. M. BE Baker, E Templeton, D TI MODELING AND SIMULATING THE PERFORMANCE OF TRANSPARENT SPINEL AND THE EFFECT OF DEFECTS ON DYNAMIC RESPONSE SO BALLISTICS 2011: 26TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOL 1 AND VOL 2 LA English DT Proceedings Paper CT 26th International Symposium on Ballistics CY SEP 12-16, 2011 CL Miami, FL SP Ballist Div Natl Def Ind Assoc (NDIA) AB The development of next generation ceramics is a key to providing enhanced protection capability and extended service performance for future armored windows for the U.S. Army. A development program is underway to improve processing and reduce costs associated with transparent ceramic materials, such as magnesium aluminate spinel, MgAl(2)O(4). A critical element of this development is to understand the influence of defects on the failure mechanisms, both statically and dynamically. The ballistic behavior of a transparent magnesium aluminate spinel, polyurethane and polycarbonate laminate is simulated using the non-linear ANSYS/AUTODYN commercial package. The purpose of this report is to demonstrate the importance of modeling tools in advancing ceramic transparent armor materials to fielded applications. The effect of various shape defects, located in the interior of spinel, on the failure and damage propagation of the transparent material will be discussed in detail. C1 [Fountzoulas, C. G.] USA, Res Lab, Weap & Mat Res Directorate, RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA. RP Fountzoulas, CG (reprint author), USA, Res Lab, Weap & Mat Res Directorate, RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA. NR 6 TC 0 Z9 0 U1 0 U2 2 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-052-5 PY 2011 BP 1437 EP 1444 PG 8 WC Engineering, Multidisciplinary; Mechanics SC Engineering; Mechanics GA BXY64 UT WOS:000297632200155 ER PT J AU Green, WH Cho, KC AF Green, W. H. Cho, K. C. BE Baker, E Templeton, D TI NONDESTRUCTIVE ASSESSMENT AND ANALYSIS OF PENETRATION DAMAGE IN NOVEL Mg MATERIALS SO BALLISTICS 2011: 26TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOL 1 AND VOL 2 LA English DT Proceedings Paper CT 26th International Symposium on Ballistics CY SEP 12-16, 2011 CL Miami, FL SP Ballist Div Natl Def Ind Assoc (NDIA) AB X-ray computed tomography (XCT) has been shown to be an important non-destructive evaluation (NDE) technique for revealing the spatial distribution of ballistically-induced damage in metals, ceramics, and encapsulated ceramic structures. Previous and ongoing work in this area includes assessment of ballistically induced damage in relatively lightweight individual ceramic targets and ceramic armor panels. In this paper the ballistic damage in two novel Mg alloy samples was completely scanned and extensively evaluated using XCT 2-D and 3-D analysis. Features of the damage in the samples were compared and contrasted. Some features of the damage were correlated with physical processes of damage initiation and growth. XCT scans and analyses of damage in the samples will be shown and discussed. This will include virtual 3-D solid visualizations and some quantitative analysis of damage features. C1 [Green, W. H.; Cho, K. C.] USA, Res Lab, Weap & Mat Res Directorate, RDRL WMM D, Aberdeen Proving Ground, MD 21005 USA. RP Green, WH (reprint author), USA, Res Lab, Weap & Mat Res Directorate, RDRL WMM D, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. NR 6 TC 0 Z9 0 U1 0 U2 1 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-052-5 PY 2011 BP 1456 EP 1467 PG 12 WC Engineering, Multidisciplinary; Mechanics SC Engineering; Mechanics GA BXY64 UT WOS:000297632200157 ER PT B AU Chaplin, R AF Chaplin, R. BE Baker, E Templeton, D TI EULERIAN VS. LAGRANGIAN METHODS IN THE FINITE ELEMENT ANALYSIS OF SMALL CALIBER THICK PLATE PENETRATIONS EVENTS SO BALLISTICS 2011: 26TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOL 1 AND VOL 2 LA English DT Proceedings Paper CT 26th International Symposium on Ballistics CY SEP 12-16, 2011 CL Miami, FL SP Ballist Div Natl Def Ind Assoc (NDIA) AB Hard targets used in the development of small caliber munitions often consist of finite and semi infinite thick plates made of various grades of steel. Lagrangian FEA is commonly used in development effort to assist in the design decision process. This method is computationally inexpensive having a large data base of proven material. However rapid mass loss due to the needed element death may make the results questionable. Eulerian modeling methods do not require element deletion to create separation of surfaces; therefore, the aforementioned mass loss is avoided. However, Eulerian models are computationally expensive and suffer their own specific limitations. Finite Element Analysis using the combined Lagrangian-Eulerian provides a compromise to using solely either method. Finite element analysis will be conducted on a given bullet against a mild steel target. The bullet and plate are changed between the Eulerian and the Lagrangian domain and the results are compared with true experimental test data. C1 USA, RDAR MEF E, Computat Modeling & Anal Team Small Caliber Munit, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. RP Chaplin, R (reprint author), USA, RDAR MEF E, Computat Modeling & Anal Team Small Caliber Munit, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-052-5 PY 2011 BP 1478 EP 1487 PG 10 WC Engineering, Multidisciplinary; Mechanics SC Engineering; Mechanics GA BXY64 UT WOS:000297632200159 ER PT J AU Auten, JR AF Auten, J. R., Sr. BE Baker, E Templeton, D TI A COMPARISON OF PENETRATION ALGORITHMS: PREDICTIONS VS. TEST DATA FOR KINETIC ENERGY RODS SO BALLISTICS 2011: 26TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOL 1 AND VOL 2 LA English DT Proceedings Paper CT 26th International Symposium on Ballistics CY SEP 12-16, 2011 CL Miami, FL SP Ballist Div Natl Def Ind Assoc (NDIA) AB Vulnerability/lethality models use penetration algorithms to predict penetration of threats into armor, but the applicability of the algorithms is not well known. The use of an algorithm that is not suited to the scenario being modeled can lead to over or under predictions in the capability of the threat. The objective of this work was to review kinetic energy rod algorithms to determine the applicability of each algorithm and recommend the best algorithm for use. Six algorithms were reviewed, but can be broken into one of two basic designs, empirical algorithms and phenomenological algorithms. The empirical algorithms reviewed are the Konrad Frank version of Lanz-Odermatt (LO) and the Subramanian-Bless modification of LO. The phenomenological algorithms reviewed are Alekseevski-Tate, Frank-Zook, the Segletes version of Walker-Anderson (WA), and FATEPEN. After running all of the algorithms against the test data, the six algorithms were compared against one another. The WA algorithm was selected as the best for general usage due to its ability to handle laminate targets well, for its ability to model the plastic zones in the target and rod, and for overall good performance for all of the cases in the test data. C1 USA, Res Lab, Aberdeen Proving Ground, MD USA. RP Auten, JR (reprint author), USA, Res Lab, 328 Hopkins Rd, Aberdeen Proving Ground, MD USA. NR 26 TC 0 Z9 0 U1 0 U2 1 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-052-5 PY 2011 BP 1522 EP 1532 PG 11 WC Engineering, Multidisciplinary; Mechanics SC Engineering; Mechanics GA BXY64 UT WOS:000297632200164 ER PT J AU Talladay, TG Weinhold, C Leighton, KT Carberry, JJ Templeton, DW AF Talladay, T. G. Weinhold, C. Leighton, K. T. Carberry, J. J. Templeton, D. W. BE Baker, E Templeton, D TI INVESTIGATION OF PROJECTILE TRAJECTORY IN MULTI-HIT SCENARIOS AND THE INFLUENCE OF DAMAGE CHARACTERISTICS IN GLASS-CERAMIC TRANSPARENT ARMOR SO BALLISTICS 2011: 26TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOL 1 AND VOL 2 LA English DT Proceedings Paper CT 26th International Symposium on Ballistics CY SEP 12-16, 2011 CL Miami, FL SP Ballist Div Natl Def Ind Assoc (NDIA) AB By increasing the tendency of a projectile to turn, the penetration capability of the projectile is reduced and consequently armor may be made lighter and military vehicles made more mobile. In transparent armor multi-hit scenarios, projectile turning may be influenced by damage caused by previous shots. Glass-ceramic materials are a recent addition to weight reduction in transparent armor on military vehicles. These materials exhibit damage characteristics which are different than those of soda-lime glass and may have unique interaction with projectiles in multi-hit. The effect of pre-existing damage on projectile trajectory and velocity is quantified for 25 glass-ceramic samples. An X-ray computed tomography technique is explained and used to illustrate the damage, define damage zones, observe projectile trajectory inside the samples, and correlate to residual trajectories. Data is supplied in sufficient detail to assist subsequent mesoscale modeling efforts. C1 [Talladay, T. G.; Templeton, D. W.] USA, TARDEC, Warren, MI 48397 USA. RP Talladay, TG (reprint author), USA, TARDEC, RDTA RS MS263,6501 E 11 Mile Rd, Warren, MI 48397 USA. NR 8 TC 0 Z9 0 U1 0 U2 1 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-052-5 PY 2011 BP 1533 EP 1544 PG 12 WC Engineering, Multidisciplinary; Mechanics SC Engineering; Mechanics GA BXY64 UT WOS:000297632200165 ER PT J AU Scott, BR AF Scott, B. R. BE Baker, E Templeton, D TI UNUSUAL TRANSVERSE COMPRESSION RESPONSE OF NON-WOVEN BALLISTIC LAMINATES SO BALLISTICS 2011: 26TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOL 1 AND VOL 2 LA English DT Proceedings Paper CT 26th International Symposium on Ballistics CY SEP 12-16, 2011 CL Miami, FL SP Ballist Div Natl Def Ind Assoc (NDIA) AB An analytic model called LAMP [1, 2] was modified to accommodate contemporary fiber reinforced laminate materials. One required input for the model involves an independent mechanical characterization of the composite material using a quasi-static confined compression test [3]. During these characterization tests, unexpected cyclic behavior of load/rupture/unload/reload was first observed with the unidirectional systems [2]. Woodward [3] had also observed similar, but less extensive load reversals with some of the woven ballistic grade laminates. The LAMP model combines both the quasi-static resistance stress that develops during the transverse compression with the transient forces that develop during the deceleration of the projectile. The cyclic quasi-static response suggests the additional membrane stretching of outer layers into those layers beneath. This membrane component can be a quite large component of the total retardation force and may explain why this new class of armor material is so ballistically efficient. C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Scott, BR (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 14 TC 2 Z9 2 U1 0 U2 2 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-052-5 PY 2011 BP 1859 EP 1871 PG 13 WC Engineering, Multidisciplinary; Mechanics SC Engineering; Mechanics GA BXY64 UT WOS:000297632200201 ER PT J AU Vargas-Gonzalez, LR Walsh, SM Scott, BR AF Vargas-Gonzalez, L. R. Walsh, S. M. Scott, B. R. BE Baker, E Templeton, D TI BALANCING BALLISTIC AND BACK-FACE DEFORMATION IN HELMETS: THE ROLE OF ALTERNATIVE RESINS, FIBERS, AND FIBER ARCHITECTURE IN MASS-EFFICIENT HEAD PROTECTION SO BALLISTICS 2011: 26TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOL 1 AND VOL 2 LA English DT Proceedings Paper CT 26th International Symposium on Ballistics CY SEP 12-16, 2011 CL Miami, FL SP Ballist Div Natl Def Ind Assoc (NDIA) AB One of the future goals of the Army is to produce and deliver a helmet that is significantly lighter than the current Army Combat Helmet (ACH), while also delivering all current ballistic and deformation response specifications. Results suggest that varying the content and type of resin and fiber, together with the orientation and fiber architecture, can provide a more robust and desirable combination of ballistic and dynamic deflection behavior at reduced weight. Hybridized thermoplastic aramid/ultra-high molecular weight polyethylene (UHMWPE) panels were developed and characterized, and show promise in being able to achieve ACH performance levels at a lighter weight. The effect of mechanisms of orientation, architecture, and choice of strike face on the ballistic performance (17 grain V(50) testing), back face deformation will be discussed. C1 [Vargas-Gonzalez, L. R.; Walsh, S. M.; Scott, B. R.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Vargas-Gonzalez, LR (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 8 TC 1 Z9 1 U1 2 U2 10 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-052-5 PY 2011 BP 1872 EP 1882 PG 11 WC Engineering, Multidisciplinary; Mechanics SC Engineering; Mechanics GA BXY64 UT WOS:000297632200202 ER PT J AU VanAmburg, RL AF VanAmburg, R. L. BE Baker, E Templeton, D TI A METHODOLOGY TO PREDICT PERSONNEL INJURY FROM REFLECTIVE SPALL SO BALLISTICS 2011: 26TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOL 1 AND VOL 2 LA English DT Proceedings Paper CT 26th International Symposium on Ballistics CY SEP 12-16, 2011 CL Miami, FL SP Ballist Div Natl Def Ind Assoc (NDIA) AB Fragmenting debris from ballistic impacts, which are defeated by the protective plates in body armor, also known as reflective spall, has the potential to injure personnel wearing the protective plate. This has not been evaluated in the past due to difficulties in data collection as well as a lack of information on whether or not there is a legitimate risk of injury. Our objective was to develop a test procedure and analysis process to determine the potential for serious injury from reflective spall. The testing and analysis was conducted by the Army Research Laboratory, Survivability/Lethality Analysis Directorate (ARL/SLAD). The testing included a custom experimental set-up to collect the reflective spall using ballistic gelatin. The fragments recovered in the gelatin were used to quantify the potential for significant injury to the Soldier. Personnel vulnerability modeling and analysis was conducted using the MUVES-S2 modeling and simulation software. This software allowed the analysts to quantify potential hazards to the Soldier. The Maximum Abbreviated Injury Score (MAIS) was used to determine the likelihood of significant injury. Our approach of testing and analysis was able to quantify the potential for significant injury to the Soldier. C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP VanAmburg, RL (reprint author), USA, Res Lab, 328 Hopkins Rd, Aberdeen Proving Ground, MD 21005 USA. NR 5 TC 0 Z9 0 U1 2 U2 3 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-052-5 PY 2011 BP 1942 EP 1948 PG 7 WC Engineering, Multidisciplinary; Mechanics SC Engineering; Mechanics GA BXY64 UT WOS:000297632200208 ER PT J AU Pizzolato, K AF Pizzolato, K. BE Baker, E Templeton, D TI FRAGMENT ANALYSIS FOR THE JOINT TRAUMA ANALYSIS AND PREVENTION OF INJURY IN COMBAT (JTAPIC) PROGRAM SO BALLISTICS 2011: 26TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOL 1 AND VOL 2 LA English DT Proceedings Paper CT 26th International Symposium on Ballistics CY SEP 12-16, 2011 CL Miami, FL SP Ballist Div Natl Def Ind Assoc (NDIA) AB Fragments from the threat and surrounding environment often become embedded in Service Members during an event in-theater. Analyzing these fragments is crucial to the characterization and identification of threats. Fragment analysis is one part of the Joint Trauma Analysis and Prevention of Injury in Combat (JTAPIC) Program. JTAPIC is a partnership program that was established at the U. S. Army Medical Research and Material Command (USAMRMC). JTAPIC fragments are removed during autopsy by the Armed Forces Medical Examiner Systems (AFMES) from Service Members who were killed in action (KIA). These fragments are analyzed by the U. S. Army Research Laboratory (ARL). The analysis procedure includes the sterilization, scanning, and documentation of the physical properties of the fragments. ARL determines the elemental composition of fragments using both qualitative and quantitative analysis procedures. The analysis results are used in event recreations and modeling and simulation. They results also assist JTAPIC partners with test designs and in understanding personnel vulnerabilities to threats. C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Pizzolato, K (reprint author), USA, Res Lab, 328 Hopkins Rd, Aberdeen Proving Ground, MD 21005 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-052-5 PY 2011 BP 1959 EP 1964 PG 6 WC Engineering, Multidisciplinary; Mechanics SC Engineering; Mechanics GA BXY64 UT WOS:000297632200210 ER PT J AU Gurganus, J Hisley, D Drysdale, A AF Gurganus, J. Hisley, D. Drysdale, A. BE Baker, E Templeton, D TI EXPERIMENTAL METHODOLOGY USING DIGITAL IMAGE CORRELATION TO ASSESS BALLISTIC HELMET BLUNT TRAUMA SO BALLISTICS 2011: 26TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOL 1 AND VOL 2 LA English DT Proceedings Paper CT 26th International Symposium on Ballistics CY SEP 12-16, 2011 CL Miami, FL SP Ballist Div Natl Def Ind Assoc (NDIA) AB As modern helmets have become capable of defeating the penetration capabilities of ballistic threats, Soldiers may experience head injuries due to blunt trauma caused by helmet back face deformation (BFD). We have shown that digital image correlation (DIC) is an experimentation technique that captures BFD area and rate of deformation for impacts against combat helmets. We used the DIC data to calculate a new metric; the available energy that could potentially impact a Soldier's head. The available energy obtained from DIC measurements was used to calculate the blunt criterion (BC), which in turn can provide a prediction of the probability of abbreviated injury scale (AIS) levels and, in particular, skull fracture. DIC can be used to provide dynamic helmet performance data that will allow quantitative assessment and validation of helmet performance results. C1 [Gurganus, J.; Hisley, D.; Drysdale, A.] USA, Res Lab, RDRL SLB D, Aberdeen Proving Ground, MD 21005 USA. RP Gurganus, J (reprint author), USA, Res Lab, RDRL SLB D, Aberdeen Proving Ground, MD 21005 USA. NR 3 TC 0 Z9 0 U1 0 U2 1 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-052-5 PY 2011 BP 2003 EP 2006 PG 4 WC Engineering, Multidisciplinary; Mechanics SC Engineering; Mechanics GA BXY64 UT WOS:000297632200215 ER PT J AU Frounfelker, PS Swann, SP Dietrich, GK AF Frounfelker, P. S. Swann, S. P. Dietrich, G. K. BE Baker, E Templeton, D TI A COMPREHENSIVE APPROACH TO CHARACTERIZING THE HAZARDS OF EXPLOSIVE COUNTERMEASURES WITH RESPECT TO DISMOUNTED TROOPS SO BALLISTICS 2011: 26TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOL 1 AND VOL 2 LA English DT Proceedings Paper CT 26th International Symposium on Ballistics CY SEP 12-16, 2011 CL Miami, FL SP Ballist Div Natl Def Ind Assoc (NDIA) AB Active countermeasures (ACM) are designed to increase protection to military vehicles and their occupants. Current military operations in urban environments have increased the need to understand the danger from these countermeasure technologies to dismounted troops and other personnel. The area of hazard around the interaction of the ACM and threat needs to be understood and quantified using a combination of testing and modeling and simulation (M&S). The Army Research Laboratory (ARL) has developed testing procedures and M&S tools utilizing the Operational Requirement-based Casualty Assessment (ORCA) and MUVES-S2 models to evaluate these vulnerabilities. Hazard characterization can be used to influence countermeasure development as well as the Tactics, Techniques, and Procedures (TTPs) for countermeasure-equipped platforms and personnel operating in their proximity. This paper will present the testing and data collection methodology, the M&S tools, and the visualization tools developed by ARL to assess the associated risks and hazard areas. C1 [Frounfelker, P. S.; Swann, S. P.; Dietrich, G. K.] USA, Res Lab, RDRL SLB W, Aberdeen Proving Ground, MD 21005 USA. RP Frounfelker, PS (reprint author), USA, Res Lab, RDRL SLB W, 328 Hopkins Rd, Aberdeen Proving Ground, MD 21005 USA. NR 6 TC 0 Z9 0 U1 0 U2 1 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-052-5 PY 2011 BP 2012 EP 2022 PG 11 WC Engineering, Multidisciplinary; Mechanics SC Engineering; Mechanics GA BXY64 UT WOS:000297632200217 ER PT J AU Hunt, E Burdeshaw, M AF Hunt, E. Burdeshaw, M. BE Baker, E Templeton, D TI MUVES 3-VULNERABILITY/LETHALITY ANALYSIS TOOL OF THE FUTURE SO BALLISTICS 2011: 26TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOL 1 AND VOL 2 LA English DT Proceedings Paper CT 26th International Symposium on Ballistics CY SEP 12-16, 2011 CL Miami, FL SP Ballist Div Natl Def Ind Assoc (NDIA) AB MUVES 3 is the ballistic vulnerability/lethality (V/L) analytical model of the future. The Army Research Laboratory's (ARL) Survivability/Lethality Analysis Directorate (SLAD) is replacing existing V/L modeling tools to provide more advanced analysis capabilities. MUVES 3 is envisioned to be an adaptable, integrated, and collaborative environment for conducting timely and credible ballistics V/L analyses of complex interactions in a mission/capabilities context to support decisions that save lives. The first major improvement is a graphical user interface that provides collaboration features to the analysts, engineers, target geometry modelers, and managers. Second, MUVES 3 is specifically designed to support System-of-systems (SoS) analysis by providing on-demand V/L. data to higher level simulations such as SLAD's S4 model. Lastly, MUVES 3 provides time dependent V/L data for things like fluid leakers and tire deflation which are factors crucial for simulations like S4. This paper shows examples of some notable features of the MUVES 3 model that are improvements over existing models. C1 [Hunt, E.; Burdeshaw, M.] USA, Res Lab, RDRL SLB S, Aberdeen Proving Ground, MD 21005 USA. RP Hunt, E (reprint author), USA, Res Lab, RDRL SLB S, Aberdeen Proving Ground, MD 21005 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-052-5 PY 2011 BP 2023 EP 2034 PG 12 WC Engineering, Multidisciplinary; Mechanics SC Engineering; Mechanics GA BXY64 UT WOS:000297632200218 ER PT J AU Bowers, RA AF Bowers, R. A. BE Baker, E Templeton, D TI OVERVIEW OF MUVES 3 AND THE MUVES 3 V/L SERVICE SO BALLISTICS 2011: 26TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOL 1 AND VOL 2 LA English DT Proceedings Paper CT 26th International Symposium on Ballistics CY SEP 12-16, 2011 CL Miami, FL SP Ballist Div Natl Def Ind Assoc (NDIA) AB In order to address the deficiencies of the Army Research Laboratory's (ARL's) current vulnerability/lethality (V/L) analysis simulation, ARL is developing a new V/L analysis environment. MUVES 3 is a complete analysis environment that includes improvements in input preparation, analyst collaboration, simulation performance, and result data management. New features in the simulation include the ability to calculate platform capability as a function of time and damage and the ability to analyze scenes consisting of multiple targets. MUVES 3 also includes the Vulnerability/Lethality Service (VLS) that enables higher-level models to make interactive queries of the simulation to determine the outcomes of shots on targets. This paper describes the capabilities and architecture of MUVES 3 and the VLS. In addition, it discusses how to integrate the VLS into higher-level models and how to extend MUVES 3 by incorporating lower-level models. C1 USA, Res Lab, Survivabil Lethal Anal Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Bowers, RA (reprint author), USA, Res Lab, Survivabil Lethal Anal Directorate, 238 Hopkins Rd, Aberdeen Proving Ground, MD 21005 USA. NR 2 TC 0 Z9 0 U1 0 U2 1 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-052-5 PY 2011 BP 2035 EP 2046 PG 12 WC Engineering, Multidisciplinary; Mechanics SC Engineering; Mechanics GA BXY64 UT WOS:000297632200219 ER PT J AU Siano, A AF Siano, A. BE Baker, E Templeton, D TI BALLISTIC VULNERABILITY ANALYSIS OF GROUND COMBAT VEHICLES, UNDERSTANDING THE PROCESS AND IMPACT SO BALLISTICS 2011: 26TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOL 1 AND VOL 2 LA English DT Proceedings Paper CT 26th International Symposium on Ballistics CY SEP 12-16, 2011 CL Miami, FL SP Ballist Div Natl Def Ind Assoc (NDIA) AB Given current conflicts and the ever-impending threats to our nation, it is imperative that the Department of Defense understand the ballistic vulnerabilities of our Army's vehicles. To assist in this understanding, the Army Research Laboratory (ARL) Survivability /Lethality Analysis Directorate (SLAD) analyze the ballistic vulnerability of fielded and future combat vehicles. To conduct these vulnerability analyses, ARL/SLAD uses the MUVES-S2 model. MUVES-S2 analyses require data to characterize the ballistic threat, target, and the interaction of these two. This paper will provide an overview of the process and impact of analyzing ballistic vulnerability of ground combat vehicles. C1 USA, Res Lab, AMSRD SRL SL BG, Aberdeen Proving Ground, MD 21005 USA. RP Siano, A (reprint author), USA, Res Lab, AMSRD SRL SL BG, 328 Hopkins Rd,Bldg 247,Room 206, Aberdeen Proving Ground, MD 21005 USA. NR 3 TC 0 Z9 0 U1 0 U2 1 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-052-5 PY 2011 BP 2062 EP 2066 PG 5 WC Engineering, Multidisciplinary; Mechanics SC Engineering; Mechanics GA BXY64 UT WOS:000297632200222 ER PT J AU Saxena, A Sun, W Fedorko, JM Koplovitz, I Doctor, BP AF Saxena, Ashima Sun, Wei Fedorko, James M. Koplovitz, Irwin Doctor, Bhupendra P. TI Prophylaxis with human serum butyrylcholinesterase protects guinea pigs exposed to multiple lethal doses of soman or VX SO BIOCHEMICAL PHARMACOLOGY LA English DT Article DE Human serum butyrylcholinesterase; Soman; Vx; Bioscavenger; Prophylaxis; Guinea pigs ID NERVE AGENT TOXICITY; ACETYLCHOLINESTERASE PROPHYLAXIS; COCAINE TOXICITY; MICE; CHOLINESTERASE; PRETREATMENT; TOXICOKINETICS; INHIBITION; ANTIDOTE; MONKEYS AB Human serum butyrylcholinesterase (Hu BChE) is currently under advanced development as a bioscavenger for the prophylaxis of organophosphorus (OP) nerve agent toxicity in humans. It is estimated that a dose of 200 mg will be required to protect a human against 2 x LD(50) of soman. To provide data for initiating an investigational new drug application for the use of this enzyme as a bioscavenger in humans, we purified enzyme from Cohn fraction IV-4 paste and initiated safety and efficacy evaluations in mice, guinea pigs, and non-human primates. In mice, we demonstrated that a single dose of enzyme that is 30 times the therapeutic dose circulated in blood for at least four days and did not cause any clinical pathology in these animals. In this study, we report the results of safety and efficacy evaluations conducted in guinea pigs. Various doses of Hu BChE delivered by i.m. injections peaked at similar to 24 h and had a mean residence time of 78-103 h. Hu BChE did not exhibit any toxicity in guinea pigs as measured by general observation, serum chemistry, hematology, and gross and histological tissue changes. Efficacy evaluations showed that Hu BChE protected guinea pigs from an exposure of 5.5 x LD(50) of soman or 8 x LD(50) of VX. These results provide convincing data for the development of Hu BChE as a bioscavenger that can protect humans against all OP nerve agents. Published by Elsevier Inc. C1 [Saxena, Ashima; Sun, Wei; Fedorko, James M.; Doctor, Bhupendra P.] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. [Koplovitz, Irwin] USA, Med Res Inst Chem Def, Drug Assessment Div, Aberdeen Proving Ground, MD 21010 USA. RP Saxena, A (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM ashima.saxena@us.army.mil NR 29 TC 43 Z9 44 U1 1 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0006-2952 J9 BIOCHEM PHARMACOL JI Biochem. Pharmacol. PD JAN 1 PY 2011 VL 81 IS 1 BP 164 EP 169 DI 10.1016/j.bcp.2010.09.007 PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 690UJ UT WOS:000285033600018 PM 20846507 ER PT J AU Jackson, MA Dunlap, CA Shearer, JF Heilman, MA Palmquist, DE AF Jackson, Mark A. Dunlap, Christopher A. Shearer, Judy F. Heilman, Mark A. Palmquist, Debra E. TI The impact of temperature on the production and fitness of microsclerotia of the fungal bioherbicide Mycoleptodiscus terrestris SO BIOCONTROL SCIENCE AND TECHNOLOGY LA English DT Article DE sclerotia; bioherbicide; fermentation; hydrilla; aquatic weed ID LIQUID CULTURE PRODUCTION; BIOLOGICAL-CONTROL AGENTS; COLLETOTRICHUM-TRUNCATUM; METARHIZIUM-ANISOPLIAE; HYDRILLA-VERTICILLATA; RELATIVE-HUMIDITY; MANAGEMENT; PATHOGEN; GERMINATION; BIOCONTROL AB The impact of growth temperature was evaluated for the fungal plant pathogen Mycoleptodiscus terrestris over a range of temperatures (20-36 degrees C). The effect of temperature on biomass accumulation, colony forming units (cfu), and microsclerotia production was determined. Culture temperatures of 24-30 degrees C produced significantly higher biomass accumulations and 20-24 degrees C resulted in a significantly higher cfu. The growth of M. terrestris was greatly reduced at temperatures above 30 degrees C and was absent at 36 degrees C. The highest microsclerotia concentrations were produced over a wide range of temperatures (20-30 degrees C). These data suggest that a growth temperature of 24 degrees C would optimize the parameters evaluated in this study. In addition to growth parameters, we also evaluated the desiccation tolerance and storage stability of air-dried microsclerotial preparations from these cultures during storage at 4 degrees C. During 5 months storage, there was no significant difference in viability for air-dried microsclerotial preparations from cultures grown at 20-30 degrees C (>72% hyphal germination) or in conidia production (sporogenic germination) for air-dried preparations from cultures grown at 20-32 degrees C. When the effect of temperature on germination by air-dried microsclerotial preparations was evaluated, data showed that temperatures of 22-30 degrees C were optimal for hyphal and sporogenic germination. Air-dried microsclerotial preparations did not germinate hyphally at 36 degrees C or sporogenically at 20, 32, 34, or 36 degrees C. These data show that temperature does impact the growth and germination of M. terrestris and suggest that water temperature may be a critical environmental consideration for the application of air-dried M. terrestris preparations for use in controlling hydrilla. C1 [Jackson, Mark A.; Dunlap, Christopher A.; Palmquist, Debra E.] ARS, USDA, Natl Ctr Agr Utilizat Res, Crop Bioprotect Res Unit, Peoria, IL 61604 USA. [Shearer, Judy F.] USA, Corps Engineers, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Heilman, Mark A.] SePRO Corp, Whitakers, NC 27891 USA. RP Jackson, MA (reprint author), ARS, USDA, Natl Ctr Agr Utilizat Res, Crop Bioprotect Res Unit, Peoria, IL 61604 USA. EM mark.jackson@ars.usda.gov FU Florida Fish and Wildlife Conservation Commission [PL114] FX Mention of trade names or commercial products in this [article] is solely for the purpose of providing specific information and does not imply recommendation or endorsement by the U.S. Department of Agriculture'. This research was supported, in part, through funding by the Florida Fish and Wildlife Conservation Commission, Contract #PL114. NR 43 TC 2 Z9 2 U1 2 U2 10 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0958-3157 J9 BIOCONTROL SCI TECHN JI Biocontrol Sci. Technol. PY 2011 VL 21 IS 5 BP 547 EP 562 DI 10.1080/09583157.2011.564728 PG 16 WC Biotechnology & Applied Microbiology; Entomology SC Biotechnology & Applied Microbiology; Entomology GA 750TP UT WOS:000289571200001 ER PT J AU Shutt, JE Barnes, JC Beaver, KM Higgins, GE Tewksbury, R AF Shutt, J. Eagle Barnes, J. C. Beaver, Kevin M. Higgins, George E. Tewksbury, Richard TI Does Biology Underlie the Oldest Profession? Prostitution and Sex Disparities in John Behavior SO BIODEMOGRAPHY AND SOCIAL BIOLOGY LA English DT Article ID SELF-CONTROL; VIOLENT VICTIMIZATION; DELINQUENT PEERS; CRIME; MEN; GOTTFREDSON; SOCIOLOGY; CLIENTS; WOMEN; MODEL AB This study considers a biosocial explanation of why johns, the purchasers of commercial sex exchanges, are almost exclusively male. Trivers's theory of parental investment and sexual selection predicts that differential parental investment by biological sex will lead to divergent sex-based reproductive instincts. The sex bearing the larger parental investment will tend to be choosier, whereas the sex bearing the lesser investment will tend to be relatively indiscriminate and competitive for access to sexual resources. We hypothesized that men are more likely than women to offer objects of value in exchange for access to sexual resources. Using self-reports of sex-purchasing from Add Health data (N = 14,544), we found that maleness was a robust predictor of john behavior even after controlling for well-known criminogenic risk factors. C1 [Barnes, J. C.] Univ Texas Dallas, Sch Econ Polit & Policy Sci, Richardson, TX 75080 USA. [Shutt, J. Eagle] USA, Ft Drum, New York, NY USA. [Beaver, Kevin M.] Florida State Univ, Coll Criminol & Criminal Justice, Tallahessee, FL USA. [Higgins, George E.; Tewksbury, Richard] Univ Louisville, Dept Justice Adm, Louisville, KY 40292 USA. RP Barnes, JC (reprint author), Univ Texas Dallas, Sch Econ Polit & Policy Sci, 800 W Campbell Rd, Richardson, TX 75080 USA. EM jcbarnes@utdallas.edu RI Beaver, Kevin/B-4631-2013 NR 89 TC 2 Z9 2 U1 1 U2 4 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1948-5565 J9 BIODEMOGR SOC BIOL JI Biodemography Soc. Biol. PY 2011 VL 57 IS 2 BP 155 EP 170 DI 10.1080/19485565.2011.614566 PG 16 WC Demography; Social Sciences, Biomedical; Sociology SC Demography; Biomedical Social Sciences; Sociology GA 878MN UT WOS:000299261300002 PM 22329085 ER PT J AU Ahmed, Z Wagdy, M Benjamin, M Mohamed, S Mohamed, H Ahmed, S Kanjilal, B Wieraszko, A AF Ahmed, Zaghloul Wagdy, Mekhael Benjamin, Merel Mohamed, Salah Mohamed, Hossam Ahmed, Sahar Kanjilal, Baishali Wieraszko, Andrzej TI Therapeutic Effects of Acrobatic Exercise and Magnetic Field Exposure on Functional Recovery After Spinal Cord Injury in Mice SO BIOELECTROMAGNETICS LA English DT Article DE spinal cord; lesions; magnetic stimulation; acrobatic exercise; recovery ID COMPRESSION-INJURY; LOCOMOTOR RECOVERY; LOW-FREQUENCY; ADULT RATS; STIMULATION; HIPPOCAMPAL; PLASTICITY; CONTUSION; MOUSE; MODEL AB The effects of acrobatic exercise and magnetic stimulation (MS) in mice applied either separately or in combination while on recovery after spinal cord injury have been investigated. This progress has been compared in six groups of animals. The first two groups consisted of non-injured and injured animals, respectively, which were not exposed to any treatment. The third group included injured animals that participated in an acrobatic exercise and were exposed to MS applied at the frequency of 1 Hz. The animals in the fourth group were exposed to the MS (1 Hz) only, without performing any acrobatic exercises. While the mice in the fifth group participated in the acrobatic exercise and were exposed to MS at 15 Hz, the animals in group six received an acrobatic exercise without exposure to MS. The effects of the treatment were evaluated with the Basso Mouse Scale, the Horizontal Ladder Scale, and the Abnormal Posture Scale. While all groups showed improvement at the end of the study period, the animals that received exercise combined with 1 Hz MS demonstrated the best functional improvement. The animals exposed to the MS applied at a frequency of 15 Hz combined with acrobatic exercise, and those animals that were engaged in exercise and were not exposed to the MS, performed the worst. The area of the spared white matter at the lesion center correlated well with functional recovery and was greatest in the animals that received MS (1 Hz) combined with exercise. Bioelectromagnetics 32:49-57, 2011. (C) 2010 Wiley-Liss, Inc. C1 [Ahmed, Zaghloul; Wagdy, Mekhael; Benjamin, Merel] CUNY Coll Staten Isl, Dept Phys Therapy, Staten Isl, NY 10314 USA. [Ahmed, Zaghloul; Mohamed, Salah; Mohamed, Hossam; Ahmed, Sahar; Kanjilal, Baishali; Wieraszko, Andrzej] CUNY Coll Staten Isl, Program Neurosci, Staten Isl, NY 10314 USA. [Kanjilal, Baishali] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD USA. [Wieraszko, Andrzej] CUNY Coll Staten Isl, Dept Biol, Staten Isl, NY 10314 USA. RP Ahmed, Z (reprint author), CUNY Coll Staten Isl, Dept Phys Therapy, 2800 Victory Blvd,Bldg 5N,Rm 202, Staten Isl, NY 10314 USA. EM ahmedz@mail.csi.cuny.edu FU NYS/DOH [CO23684]; PSC-CUNY [60027-37-39] FX Grant sponsors: NYS/DOH (CO23684); PSC-CUNY (to Z.A.) (60027-37-39). NR 38 TC 7 Z9 8 U1 0 U2 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0197-8462 J9 BIOELECTROMAGNETICS JI Bioelectromagnetics PD JAN PY 2011 VL 32 IS 1 BP 49 EP 57 DI 10.1002/bem.20610 PG 9 WC Biology; Biophysics SC Life Sciences & Biomedicine - Other Topics; Biophysics GA 693FV UT WOS:000285210900006 PM 20857455 ER PT J AU Groffman, PM Hardy, JP Fashu-Kanu, S Driscoll, CT Cleavitt, NL Fahey, TJ Fisk, MC AF Groffman, Peter M. Hardy, Janet P. Fashu-Kanu, Samuel Driscoll, Charles T. Cleavitt, Natalie L. Fahey, Timothy J. Fisk, Melany C. TI Snow depth, soil freezing and nitrogen cycling in a northern hardwood forest landscape SO BIOGEOCHEMISTRY LA English DT Article DE Climate change; Dissolved organic matter; Methane; Microbial biomass; Nitrate; Nitrous oxide ID BROOK-EXPERIMENTAL-FOREST; DISSOLVED ORGANIC-CARBON; SMALL HEADWATER CATCHMENTS; COARSE WOODY DEBRIS; NEW-YORK-STATE; UNITED-STATES; LEACHING LOSSES; CLIMATE-CHANGE; NEW-HAMPSHIRE; MIXED FOREST AB Increases in soil freezing associated with decreases in snow cover have been identified as a significant disturbance to nitrogen (N) cycling in northern hardwood forests. We created a range of soil freezing intensity through snow manipulation experiments along an elevation gradient at the Hubbard Brook Experimental Forest (HBEF) in the White Mountains, NH USA in order to improve understanding of the factors regulating freeze effects on nitrate (NO(3) (-)) leaching, nitrous oxide (N(2)O) flux, potential and in situ net N mineralization and nitrification, microbial biomass carbon (C) and N content and respiration, and denitrification. While the snow manipulation treatment produced deep and persistent soil freezing at all sites, effects on hydrologic and gaseous losses of N were less than expected and less than values observed in previous studies at the HBEF. There was no relationship between frost depth, frost heaving and NO(3) (-) leaching, and a weak relationship between frost depth and winter N(2)O flux. There was a significant positive relationship between dissolved organic carbon (DOC) and NO(3) (-) concentrations in treatment plots but not in reference plots, suggesting that the snow manipulation treatment mobilized available C, which may have stimulated retention of N and prevented treatment effects on N losses. While the results support the hypothesis that climate change resulting in less snow and more soil freezing will increase N losses from northern hardwood forests, they also suggest that ecosystem response to soil freezing disturbance is affected by multiple factors that must be reconciled in future research. C1 [Groffman, Peter M.] Cary Inst Ecosyst Studies, Millbrook, NY 12545 USA. [Hardy, Janet P.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Fashu-Kanu, Samuel; Driscoll, Charles T.] Syracuse Univ, Dept Civil & Environm Engn, Syracuse, NY 13244 USA. [Cleavitt, Natalie L.; Fahey, Timothy J.] Cornell Univ, Dept Nat Resources, Ithaca, NY 14853 USA. [Fisk, Melany C.] Miami Univ, Dept Zool, Oxford, OH 45056 USA. RP Groffman, PM (reprint author), Cary Inst Ecosyst Studies, Box AB, Millbrook, NY 12545 USA. EM groffmanp@caryinstitute.org RI Driscoll, Charles/F-9832-2014; OI Driscoll, Charles/0000-0003-2692-2890 FU U.S. National Science Foundation [DEB 98-10221, DEB 00-75387] FX We thank Lisa Martel for excellent field, laboratory and data analysis work. This research was supported by U.S. National Science Foundation Grants DEB 98-10221 (Hubbard Brook Long Term Ecological Research) and DEB 00-75387 (Ecosystem Studies). This research was conducted at the Hubbard Brook Experimental Forest, which is operated and maintained by the USDA Forest Service, Northern Research Station, Newtown Square, PA. This paper is a contribution to the Hubbard Brook Ecosystem Study. NR 63 TC 35 Z9 47 U1 6 U2 106 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0168-2563 J9 BIOGEOCHEMISTRY JI Biogeochemistry PD JAN PY 2011 VL 102 IS 1-3 BP 223 EP 238 DI 10.1007/s10533-010-9436-3 PG 16 WC Environmental Sciences; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Geology GA 695GQ UT WOS:000285359000015 ER PT J AU Hoover, EE Young, MD Chandler, EV Luo, AD Field, JJ Sheetz, KE Sylvester, AW Squier, JA AF Hoover, Erich E. Young, Michael D. Chandler, Eric V. Luo, Anding Field, Jeffrey J. Sheetz, Kraig E. Sylvester, Anne W. Squier, Jeff A. TI Remote focusing for programmable multi-layer differential multiphoton microscopy SO BIOMEDICAL OPTICS EXPRESS LA English DT Article ID PHOTON-COUNTING MICROSCOPY; SCANNING MICROSCOPY; TIME; EXCITATION AB We present the application of remote focusing to multiphoton laser scanning microscopy and utilize this technology to demonstrate simultaneous, programmable multi-layer imaging. Remote focusing is used to independently control the axial location of multiple focal planes that can be simultaneously imaged with single element detection. This facilitates volumetric multiphoton imaging in scattering specimens and can be practically scaled to a large number of focal planes. Further, it is demonstrated that the remote focusing control can be synchronized with the lateral scan directions, enabling imaging in orthogonal scan planes. (C) 2010 Optical Society of America C1 [Hoover, Erich E.; Young, Michael D.; Chandler, Eric V.; Field, Jeffrey J.; Squier, Jeff A.] Colorado Sch Mines, Ctr Microintegrated Opt Adv Bioimaging & Control, Golden, CO 80401 USA. [Hoover, Erich E.; Young, Michael D.; Chandler, Eric V.; Field, Jeffrey J.; Squier, Jeff A.] Colorado Sch Mines, Dept Phys, Golden, CO 80401 USA. [Luo, Anding; Sylvester, Anne W.] Univ Wyoming, Dept Mol Biol, Laramie, WY 82071 USA. [Sheetz, Kraig E.] US Mil Acad, Dept Phys & Nucl Engn, West Point, NY 10996 USA. RP Hoover, EE (reprint author), Colorado Sch Mines, Ctr Microintegrated Opt Adv Bioimaging & Control, 1523 Illinois St, Golden, CO 80401 USA. EM ehoover@mines.edu RI LUO, ANDING/F-2572-2014 OI LUO, ANDING/0000-0002-2603-8854 FU National Institute of Biomedical Imaging and Bioengineering [EB-003832]; National Science Foundation REMRSEC; National Science Foundation [DBI-0501862] FX This work was funded by the National Institute of Biomedical Imaging and Bioengineering under the Bioengineering Research Partnership EB-003832. Eric V. Chandler acknowledges the support of the National Science Foundation REMRSEC. Funding for Anne W. Sylvester and Anding Luo is provided by the National Science Foundation (grant DBI-0501862). Many thanks go to Dawn N. Vitek for providing the femtosecond laser micromachined fused quartz sample. We would also like to thank Professor Virgis Barzda for recognizing the unique characteristics of our imaging system and dubbing it differential multiphoton microscopy. NR 29 TC 9 Z9 9 U1 1 U2 14 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 2156-7085 J9 BIOMED OPT EXPRESS JI Biomed. Opt. Express PD JAN 1 PY 2011 VL 2 IS 1 BP 113 EP 122 DI 10.1364/BOE.2.000113 PG 10 WC Biochemical Research Methods; Optics; Radiology, Nuclear Medicine & Medical Imaging SC Biochemistry & Molecular Biology; Optics; Radiology, Nuclear Medicine & Medical Imaging GA 886RT UT WOS:000299872300011 PM 21326641 ER PT J AU Finch, AS Mackie, TD Sund, CJ Sumner, JJ AF Finch, Amethist S. Mackie, Timothy D. Sund, Christian J. Sumner, James J. TI Metabolite analysis of Clostridium acetobutylicum: Fermentation in a microbial fuel cell SO BIORESOURCE TECHNOLOGY LA English DT Article DE Microbial fuel cells; MFC; Fermentation products; Clostridium acetobutylicum; Current generation ID BUTANOL; GENERATION; BACTERIA; ACETONE AB Microbial fuel cells (MFCs) were used to monitor metabolism changes in Clostridium acetobutylicum fermentations. When MFCs were inoculated with C. acetobutylicum, they generated a unique voltage output pattern where two distinct voltage peaks occurred over a weeklong period. This result was markedly different to previously studied organisms which usually generate one sustained voltage peak. Analysis of the fermentation products indicated that the dual voltage peaks correlated with glucose metabolism. The first voltage peak correlated with acidogenic metabolism (acetate and butyrate production) and the second peak with solventogenic metabolism (acetone and butanol production). This demonstrates that MFCs can be applied as a novel tool to monitor the shift from acid production to solvent production in C. acetobutylicum. Published by Elsevier Ltd. C1 [Finch, Amethist S.; Mackie, Timothy D.; Sund, Christian J.; Sumner, James J.] USA, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. RP Sumner, JJ (reprint author), USA, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. EM james.sumner1@us.army.mil RI sund, christian/G-3424-2013; Finch, Amethist/H-9510-2013 OI Finch, Amethist/0000-0002-4650-6301 NR 17 TC 28 Z9 29 U1 2 U2 33 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0960-8524 J9 BIORESOURCE TECHNOL JI Bioresour. Technol. PD JAN PY 2011 VL 102 IS 1 SI SI BP 312 EP 315 DI 10.1016/j.biortech.2010.06.149 PG 4 WC Agricultural Engineering; Biotechnology & Applied Microbiology; Energy & Fuels SC Agriculture; Biotechnology & Applied Microbiology; Energy & Fuels GA 699IY UT WOS:000285658300042 PM 20655198 ER PT S AU Hankus, ME Stratis-Cullum, DN Pellegrino, PM AF Hankus, Mikella E. Stratis-Cullum, Dimitra N. Pellegrino, Paul M. BE Mohseni, H Agahi, MH Razeghi, M TI Surface enhanced Raman scattering (SERS)-based next generation commercially available substrate: physical characterization and biological application SO BIOSENSING AND NANOMEDICINE IV SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Biosensing and Nanomedicine IV CY AUG 21-23, 2011 CL San Diego, CA SP SPIE DE Surface enhanced Raman scattering; Raman; SERS; substrate; biological; energetic; hazard; Klarite AB The development of a sensing platform capable of detecting and identifying hazards including biological, chemical, and energetic in nature is a long sought after goal of the Army and many other first responders. Surface enhanced Raman scatting (SERS) is one spectroscopic technique gaining popularity as a solution to many sensing needs due to its many advantages such as high sensitivity, little to no sample preparation required, and use in numerous environmental settings). Despite all the advantages of SERS, it still remains a marginalized sensing technique primarily due to the challenges in fabricating a reliable, highly sensitive and reproducible nanoscale surface. In this work, we show that many of these challenges have been overcome with a newly developed commercially available Klarite SERS substrate. These substrates are fabricated in a fashion similar to standard Klarite substrates, but due to changes in size and spacing of the inverted pyramidal structurethere is an overall increase of SERS sensing capabilities of up to 4 orders of magnitude. In this proceeding paper, the next generation Klarite (308 and 309) substrates are characterized, analyte sensitivity demonstrated at 633 nm and 785 nm, and a brief discussion of their biological sensing capabilities is presented. C1 [Hankus, Mikella E.; Stratis-Cullum, Dimitra N.; Pellegrino, Paul M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Hankus, ME (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RI Hankus, Mikella/A-9005-2012 NR 24 TC 2 Z9 2 U1 1 U2 6 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-709-4 J9 PROC SPIE PY 2011 VL 8099 AR 80990N DI 10.1117/12.893842 PG 10 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Optics SC Engineering; Science & Technology - Other Topics; Optics GA BXY10 UT WOS:000297591900010 ER PT J AU Cooper, DB Kennedy, JE Cullen, MA Critchfield, EN Amador, RR Bowles, AO AF Cooper, Douglas B. Kennedy, Jan E. Cullen, Maren A. Critchfield, Eda. N. Amador, Ricardo R. Bowles, Amy O. TI Association between combat stress and post-concussive symptom reporting in OEF/OIF service members with mild traumatic brain injuries SO BRAIN INJURY LA English DT Article DE Mild traumatic brain injury; blast injury; post-traumatic stress disorder; post-concussion syndrome ID POSTCONCUSSION SYNDROME; PSYCHOMETRIC PROPERTIES; PTSD CHECKLIST; BASE RATES; DISORDER; IRAQ; AFGHANISTAN; VETERANS; CRITERIA AB Objective: The relationship between combat stress and post-concussive symptoms in service members with mild traumatic brain injuries (mTBI) is poorly understood. It was hypothesized that the co-occurrence of combat stress would have a significant effect on the severity of post-concussive complaints, specifically on emotional and cognitive symptoms. Methods: Four hundred and seventy-two combat-deployed service members with mTBI completed self-report inventories of post-traumatic stress and post-concussive symptoms. Two groups were formed based on post-traumatic stress symptoms (High Combat Stress and Low Combat Stress). Results: A 3-8-fold increase in post-concussive symptoms was observed when comparing the High and Low Combat Stress Groups. Elevations in post-concussive symptom reporting were not limited to emotional and/or cognitive symptoms, but rather were inclusive of all measured post-concussive symptoms. Conclusions: The findings of the present study suggest that non-brain injury-related factors, such as high-levels of combat stress, may impact post-concussive symptom reporting in this population, further confounding the accuracy of the post-concussion syndrome (PCS) diagnosis. Considerable caution should be exercised in making the diagnosis of PCS in concussed service members with co-occurring combat-stress disorders. C1 [Cooper, Douglas B.] Brooke Army Med Ctr, MCHE DOR TBI, Traumat Brain Injury Serv, Dept Orthoped & Rehabil, Ft Sam Houston, TX 78234 USA. [Kennedy, Jan E.; Cullen, Maren A.; Amador, Ricardo R.] Brooke Army Med Ctr, Def & Vet Brain Injury Ctr, Ft Sam Houston, TX 78234 USA. RP Cooper, DB (reprint author), Brooke Army Med Ctr, MCHE DOR TBI, Traumat Brain Injury Serv, Dept Orthoped & Rehabil, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM douglas.cooper2@amedd.army.mil RI Schueter, nicos/A-3625-2014 NR 25 TC 49 Z9 50 U1 2 U2 7 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0269-9052 J9 BRAIN INJURY JI Brain Inj. PD JAN PY 2011 VL 25 IS 1 BP 1 EP 7 DI 10.3109/02699052.2010.531692 PG 7 WC Neurosciences; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA 731JI UT WOS:000288101700001 PM 21117916 ER PT J AU Reisner, AT Xu, D Ryan, KL Convertino, VA Rickards, CA Mukkamala, R AF Reisner, A. T. Xu, D. Ryan, K. L. Convertino, V. A. Rickards, C. A. Mukkamala, R. TI Monitoring non-invasive cardiac output and stroke volume during experimental human hypovolaemia and resuscitation SO BRITISH JOURNAL OF ANAESTHESIA LA English DT Article DE arterial pressure, measurement; blood, loss; cardiovascular system, responses; equipment, finapres; monitoring, cardiopulmonary ID BODY NEGATIVE-PRESSURE; WAVE-FORM ANALYSIS; IMPEDANCE CARDIOGRAPHY; PULSE PRESSURE; MODEL; SHOCK; HYPOTENSION; VALIDATION; TOLERANCE; DYNAMICS AB Background. Multiple methods for non-invasive measurement of cardiac output (CO) and stroke volume (SV) exist. Their comparative capabilities are not clearly established. Methods. Healthy human subjects (n=21) underwent central hypovolaemia through progressive lower body negative pressure (LBNP) until the onset of presyncope, followed by termination of LBNP, to simulate complete resuscitation. Measurement methods were electrical bioimpedance (EBI) of the thorax and three measurements of CO and SV derived from the arterial blood pressure (ABP) waveform: the Modelflow (MF) method, the long-time interval (LTI) method, and pulse pressure (PP). We computed areas under receiver-operating characteristic curves (ROC AUCs) for the investigational metrics, to determine how well they discriminated between every combination of LBNP levels. Results. LTI and EBI yielded similar reductions in SV during progressive hypovolaemia and resuscitation (correlation coefficient 0.83) with ROC AUCs for distinguishing major LBNP (-60 mm Hg) vs resuscitation (0 mm Hg) of 0.98 and 0.99, respectively. MF yielded very similar reductions and ROC AUCs during progressive hypovolaemia, but after resuscitation, MF-CO did not return to baseline, yielding lower ROC AUCs (Delta ROC AUC range, -0.18 to -0.26, P < 0.01). PP declined during hypovolaemia but tended to be an inferior indicator of specific LBNP levels, and PP did not recover during resuscitation, yielding lower ROC curves (P < 0.01). Conclusions. LTI, EBI, and MF were able to track progressive hypovolaemia. PP decreased during hypovolaemia but its magnitude of reduction underestimated reductions in SV. PP and MF were inferior for the identification of resuscitation. C1 [Reisner, A. T.] Massachusetts Gen Hosp, Dept Emergency Med, Boston, MA 02114 USA. [Xu, D.; Mukkamala, R.] Michigan State Univ, Dept Elect & Comp Engn, E Lansing, MI 48824 USA. [Ryan, K. L.; Convertino, V. A.; Rickards, C. A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Reisner, AT (reprint author), Massachusetts Gen Hosp, Dept Emergency Med, Boston, MA 02114 USA. EM areisner@partners.org RI Xu, Da/A-6423-2012 FU United States Army MRMC [W23RYX6023N603, 604]; NHLBI [HL-080568] FX This work was supported by the United States Army MRMC Grant W23RYX6023N603 and 604 and by NHLBI Grant HL-080568. NR 33 TC 29 Z9 29 U1 2 U2 7 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0007-0912 J9 BRIT J ANAESTH JI Br. J. Anaesth. PD JAN PY 2011 VL 106 IS 1 BP 23 EP 30 DI 10.1093/bja/aeq295 PG 8 WC Anesthesiology SC Anesthesiology GA 692YX UT WOS:000285192900005 PM 21051492 ER PT J AU Lahoud, N AF Lahoud, Nelly TI Jihad in Saudi Arabia: Violence and Pan-Islamism since 1979 SO BRITISH JOURNAL OF MIDDLE EASTERN STUDIES LA English DT Book Review C1 [Lahoud, Nelly] US Mil Acad, New York, NY USA. RP Lahoud, N (reprint author), US Mil Acad, New York, NY USA. NR 1 TC 0 Z9 0 U1 1 U2 1 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1353-0194 J9 BRIT J MIDDLE E STUD JI Br. J. Middle East. Stud. PY 2011 VL 38 IS 1 BP 127 EP 129 PG 3 WC Area Studies; History SC Area Studies; History GA 776JD UT WOS:000291529400011 ER PT J AU Kalb, SR Baudys, J Smith, TJ Pirkle, JL Barr, JR AF Kalb, Suzanne R. Baudys, Jakub Smith, Theresa J. Pirkle, James L. Barr, John R. BE Stulik, J Toman, R Butaye, P Ulrich, RG TI Subtype and Toxin Variant Identification of Botulinum Neurotoxin Type A Using Proteomics Techniques SO BSL3 AND BSL4 AGENTS: PROTEOMICS, GLYCOMICS, AND ANTIGENICITY LA English DT Article; Book Chapter ID NEUROTRANSMITTER RELEASE; INFANT BOTULISM; SEROTYPE-A; SNAP-25; PROTEIN; CLEAVES; TETANUS; BOND; PROTEOLYSIS; PEPTIDES C1 [Kalb, Suzanne R.; Baudys, Jakub; Pirkle, James L.; Barr, John R.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA 30341 USA. [Smith, Theresa J.] US Army Med Res, Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Kalb, SR (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, 4770 Buford Hwy NE, Atlanta, GA 30341 USA. OI Kalb, Suzanne/0000-0002-8067-136X NR 29 TC 1 Z9 1 U1 0 U2 0 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PAPPELALLEE 3, W-69469 WEINHEIM, GERMANY BN 978-3-527-32780-5 PY 2011 BP 153 EP 165 D2 10.1002/9783527638192 PG 13 WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Genetics & Heredity SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Genetics & Heredity GA BA9WE UT WOS:000339912800016 ER PT J AU Natesan, M Keasey, S Ulrich, RG AF Natesan, Mohan Keasey, Sarah Ulrich, Robert G. BE Stulik, J Toman, R Butaye, P Ulrich, RG TI Protein Microarrays for Antigen Discovery SO BSL3 AND BSL4 AGENTS: PROTEOMICS, GLYCOMICS, AND ANTIGENICITY LA English DT Article; Book Chapter ID HUMAN IMMUNE-RESPONSE; GENOME ANNOTATION; MATURE VIRION; VACCINIA; VIRUS C1 [Natesan, Mohan; Keasey, Sarah; Ulrich, Robert G.] US Army Med Res, Inst Infect Dis, Dept Immunol, Frederick, MD 21702 USA. RP Natesan, M (reprint author), US Army Med Res, Inst Infect Dis, Dept Immunol, 1425 Porter St, Frederick, MD 21702 USA. NR 19 TC 0 Z9 0 U1 0 U2 0 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PAPPELALLEE 3, W-69469 WEINHEIM, GERMANY BN 978-3-527-32780-5 PY 2011 BP 167 EP 178 D2 10.1002/9783527638192 PG 12 WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Genetics & Heredity SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Genetics & Heredity GA BA9WE UT WOS:000339912800017 ER PT J AU Brothers, ST AF Brothers, Steven T. TI Peacebuilding SO CAMBRIDGE REVIEW OF INTERNATIONAL AFFAIRS LA English DT Book Review C1 [Brothers, Steven T.] USA, Stennis Space Ctr, MS 39529 USA. RP Brothers, ST (reprint author), USA, Stennis Space Ctr, MS 39529 USA. NR 2 TC 0 Z9 0 U1 0 U2 1 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0955-7571 J9 CAMB REV INT AFF JI Camb. Rev. Int. Aff. PY 2011 VL 24 IS 3 BP 537 EP 538 PG 2 WC International Relations; Political Science SC International Relations; Government & Law GA 877YH UT WOS:000299218100012 ER PT J AU Gibert, M Monier, MN Ruez, R Hale, ML Stiles, BG Benmerah, A Johannes, L Lamaze, C Popoff, MR AF Gibert, Maryse Monier, Marie-Noelle Ruez, Richard Hale, Martha L. Stiles, Bradley G. Benmerah, Alexandre Johannes, Ludger Lamaze, Christophe Popoff, Michel R. TI Endocytosis and toxicity of clostridial binary toxins depend on a clathrin-independent pathway regulated by Rho-GDI SO CELLULAR MICROBIOLOGY LA English DT Article ID PERFRINGENS-IOTA-TOXIN; BOTULINUM C2 TOXIN; RECEPTOR-MEDIATED ENDOCYTOSIS; COATED VESICLE FORMATION; LIPID BILAYER-MEMBRANES; CELL CHAPERONE HSP90; ADP-RIBOSYLTRANSFERASE; BIOLOGICAL-ACTIVITY; BINDING-COMPONENT; CHANNEL FORMATION AB P>Clostridial binary toxins, such as Clostridium perfringens Iota and Clostridium botulinum C2, are composed of a binding protein (Ib and C2II respectively) that recognizes distinct membrane receptors and mediates internalization of a catalytic protein (Ia and C2-I respectively) with ADP-ribosyltransferase activity that disrupts the actin cytoskeleton. We show here that the endocytic pathway followed by these toxins is independent of clathrin but requires the activity of dynamin and is regulated by Rho-GDI. This endocytic pathway is similar to a recently characterized clathrin-independent pathway followed by the interleukin-2 (IL2) receptor. We found indeed that Ib and C2II colocalized intracellularly with the IL2 receptor but not the transferrin receptor after different times of endocytosis. Accordingly, the intracellular effects of Iota and C2 on the cytoskeleton were inhibited by inactivation of dynamin or by Rho-GDI whereas inhibitors of clathrin-dependent endocytosis had no protective effect. C1 [Monier, Marie-Noelle; Ruez, Richard; Johannes, Ludger; Lamaze, Christophe] CNRS, UMR144, F-75248 Paris 05, France. [Gibert, Maryse; Popoff, Michel R.] Inst Pasteur, F-75724 Paris 15, France. [Monier, Marie-Noelle; Ruez, Richard; Johannes, Ludger; Lamaze, Christophe] Inst Curie, Ctr Rech, Lab Traf Signalisat & Ciblage Intracellulaires, F-75248 Paris 05, France. [Hale, Martha L.; Stiles, Bradley G.] USA, Toxinol Div, Dept Immunol & Mol Biol, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Benmerah, Alexandre] Inst Cochin, Paris, France. RP Lamaze, C (reprint author), CNRS, UMR144, F-75248 Paris 05, France. EM christophe.lamaze@curie.fr; mpopoff@pasteur.fr RI Ruez, Richard/A-3479-2013; Popoff, Michel/O-7719-2016 OI Ruez, Richard/0000-0001-5187-2210; Popoff, Michel/0000-0001-9305-8989 FU DGA [0034056]; Fondation de France; Ministere de la Recherche FX This work was supported by a DGA Grant 0034056 to M. P. and by a Fondation de France grant to C. L. M.-N.M. and R. R. were supported by doctoral fellowships from the Ministere de la Recherche. We thank P. Roux for confocal microscopy assistance. NR 77 TC 22 Z9 23 U1 1 U2 10 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1462-5814 J9 CELL MICROBIOL JI Cell Microbiol. PD JAN PY 2011 VL 13 IS 1 BP 154 EP 170 DI 10.1111/j.1462-5822.2010.01527.x PG 17 WC Cell Biology; Microbiology SC Cell Biology; Microbiology GA 700PM UT WOS:000285756400012 PM 20846184 ER PT J AU Wang, Z Bildin, VN Yang, H Capo-Aponte, JE Yang, YQ Reinach, PS AF Wang, Zheng Bildin, Victor N. Yang, Hua Capo-Aponte, Jose E. Yang, Yuanquan Reinach, Peter S. TI Dependence of Corneal Epithelial Cell Proliferation on Modulation of Interactions Between ERK1/2 and NKCC1 SO CELLULAR PHYSIOLOGY AND BIOCHEMISTRY LA English DT Article DE Human corneal epithelial cells; NKCC1; EGF; ERK1/2; GSK-3 alpha/beta; NF-kappa B; DUSP; PKC ID CYCLE PROGRESSION; PROTEIN-KINASE; UP-REGULATION; ACTIVATION; GROWTH; COTRANSPORTER; VOLUME; MAPK; PHOSPHORYLATION; PHOSPHATASE-1 AB Epidermal growth factor (EGF) receptor stimulation or protein kinase C (PKC) activation enhances corneal epithelial cell proliferation. This response is needed to maintain corneal transparency and vision. We clarify here in human corneal epithelial cells (HCEC) the cause and effect relationships between ERK1/2 and NKCC1 phosphorylation induced by EGF receptor or PKC activation. Furthermore, the roles are evaluated of NF-kappa B and ERK1/2 in mediating negative feedback control of ERK1/2 and NKCC1 phosphorylation through modulating DUSP1 and DUSP6 expression levels. Intracellular Ca(2+) rises induced by EGF elicited NKCC1 phosphorylation through ERK1/2 activation. Bumetanide suppressed EGF-induced NKCC1 phosphorylation, transient cell swelling and cell proliferation. This cause and effect relationship is similar to that induced by PKC stimulation. NKCC1 activation occurred through time-dependent increases in protein-protein interaction between ERK1/2 and NKCC1, which were proportional to EGF concentration. DUSP6 upregulation obviated EGF and PKC-induced NKCC1 phosphorylation. NF-kappa B inhibition by PDTC prolonged ERK1/2 activation through GSK-3 inactivation leading to declines in DUSP1 expression levels. These results show that EGF receptor and PKC activation induce increases in HCEC proliferation through ERK1/2 interaction with NKCC1. This response is modulated by changes in DUSP1- and DUSP6-mediated negative feedback control of ERK1/2-induced NKCC1 phosphorylation. Copyright (C) 2011 S. Karger AG, Basel C1 [Wang, Zheng; Bildin, Victor N.; Yang, Hua; Capo-Aponte, Jose E.; Yang, Yuanquan; Reinach, Peter S.] SUNY, Dept Biol Sci, State Coll Optometry, New York, NY 10036 USA. [Capo-Aponte, Jose E.] USA, Visual Sci Branch, Aeromed Res Lab, Fort Rucker, AL USA. RP Reinach, PS (reprint author), SUNY, Dept Biol Sci, State Coll Optometry, New York, NY 10036 USA. EM preinach@sunyopt.edu FU NEI [EY04795]; Department of Defense [W81XWH-09-2-0162] FX This work was supported grants from NEI EY04795 and the Department of Defense (W81XWH-09-2-0162). NR 37 TC 7 Z9 9 U1 0 U2 3 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1015-8987 J9 CELL PHYSIOL BIOCHEM JI Cell. Physiol. Biochem. PY 2011 VL 28 IS 4 BP 703 EP 714 DI 10.1159/000335764 PG 12 WC Cell Biology; Physiology SC Cell Biology; Physiology GA 867SL UT WOS:000298474000014 PM 22178882 ER PT S AU Hankus, ME Stratis-Cullum, DN Pellegrino, PM AF Hankus, Mikella E. Stratis-Cullum, Dimitra N. Pellegrino, Paul M. BE Fountain, AW Gardner, PJ TI Characterization of next-generation commercial surface-enhanced Raman scattering (SERS) substrates SO CHEMICAL, BIOLOGICAL, RADIOLOGICAL, NUCLEAR, AND EXPLOSIVES (CBRNE) SENSING XII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XII CY APR 26-28, 2011 CL Orlando, FL SP SPIE DE SERS; Raman; Klarite; biological; chemical; surface enhanced Raman scattering; hazard ID SINGLE-MOLECULE; IDENTIFICATION; SPECTROSCOPY; BACTERIA AB Surface-enhanced Raman scattering (SERS)-based techniques are increasingly used for Army, first responder and defense relevant applications. Commonly SERS is used for the identification and characterization chemical and biological hazards, energetic materials and medical applications. SERS, like most Raman-based techniques is an beneficial analytical method to use in theatre as it offers many distinct advantages. SERS advantages include: straightforward sample identification, little to no sample preparation requirements, applicability in many environments, freedom from water interference, ability to be used with a variety of laser sources, and specific sample spectrum directly link to vibrations within the molecule constituents of the target. Despite all of these advantages, the ubiquitous use of SERS remains challenging in part due to the lack of a commercially available reproducible, high sensitivity and uniform substrates. In this paper, we discuss the need for more reproducible and sensitive SERS substrates and report on the characterization of next-generation commercial SERS substrates. The substrates analyzed are non-optimized prototypes, and demonstrate great potential for Army relevant sensing. The next-generation Klarite substrates are designated as the 308's and 309's. Within our testing parameters, the 308 demonstrates performance up to four orders of magnitude better than the standard Klarite when measuring a common SERS active analyte. For application to biological samples, all substrates demonstrate similar performance. C1 [Hankus, Mikella E.; Stratis-Cullum, Dimitra N.; Pellegrino, Paul M.] USA, Res Labs, RDRL SEE O, Adelphi, MD 20783 USA. RP Hankus, ME (reprint author), USA, Res Labs, RDRL SEE O, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RI Hankus, Mikella/A-9005-2012; Stratis-Cullum, Dimitra/F-9363-2013 OI Stratis-Cullum, Dimitra/0000-0002-4832-6945 NR 37 TC 4 Z9 4 U1 0 U2 7 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-592-2 J9 PROC SPIE PY 2011 VL 8018 AR 80180P DI 10.1117/12.886779 PG 11 WC Optics; Physics, Applied SC Optics; Physics GA BXX76 UT WOS:000297515800021 ER PT S AU Holthoff, EL Pellegrino, PM Crompton, JS Koppenhoefer, KC AF Holthoff, Ellen L. Pellegrino, Paul M. Crompton, Jeffrey S. Koppenhoefer, Kyle C. BE Fountain, AW Gardner, PJ TI Modeling of Photoacoustic Vapor Sensors Using a Multiphysics Approach SO CHEMICAL, BIOLOGICAL, RADIOLOGICAL, NUCLEAR, AND EXPLOSIVES (CBRNE) SENSING XII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XII CY APR 26-28, 2011 CL Orlando, FL SP SPIE DE Photoacoustic spectroscopy; sensor; quantum cascade laser; MEMS; multiphysics; finite element analysis ID PULSED-LASER EXCITATION; QUANTUM CASCADE LASER; TRACE GAS-ANALYSIS; CHEMICAL SENSOR; ACOUSTIC SPECTROSCOPY; MODES; MINIATURIZATION; INTEGRATION; RESONATORS; CELL AB Photoacoustic spectroscopy (PAS) is a useful monitoring technique that is well suited for trace gas detection. This method routinely exhibits detection limits at the parts-per-million (ppm) or parts-per-billion (ppb) level for gaseous samples. PAS also possesses favorable detection characteristics when the system dimensions are scaled to a micro-system design. One of the central issues related to sensor miniaturization is optimization of the photoacoustic cell geometry, especially in relationship to high acoustical amplification and reduced system noise. Current work utilizes finite element analysis software to develop a model for the characterization of a photoacoustic cell that has provided favorable vapor detection capabilities in a sensor platform. The model is used to predict the acoustic resonance frequency of the cell and the results are compared to experimental data. C1 [Holthoff, Ellen L.; Pellegrino, Paul M.] USA, Res Lab, RDRL SEE O, Adelphi, MD 20783 USA. RP Holthoff, EL (reprint author), USA, Res Lab, RDRL SEE O, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 31 TC 1 Z9 1 U1 1 U2 7 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-592-2 J9 PROC SPIE PY 2011 VL 8018 AR 801811 DI 10.1117/12.883445 PG 11 WC Optics; Physics, Applied SC Optics; Physics GA BXX76 UT WOS:000297515800033 ER PT S AU Holthoff, EL Hankus, ME Pellegrino, PM AF Holthoff, Ellen L. Hankus, Mikella E. Pellegrino, Paul M. BE Fountain, AW Gardner, PJ TI Investigating a Drop-on-Demand Microdispenser for Standardized Sample Preparation SO CHEMICAL, BIOLOGICAL, RADIOLOGICAL, NUCLEAR, AND EXPLOSIVES (CBRNE) SENSING XII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XII CY APR 26-28, 2011 CL Orlando, FL SP SPIE DE Microdrop; drop-on-demand; inkjet printer AB The existing assortment of reference sample preparation methods presents a range of variability and reproducibility concerns, making it increasingly difficult to assess chemical detection technologies on a level playing field. We are investigating a drop-on-demand table-top printing platform which offers precise liquid sample deposition and is well suited for the preparation of effective reference materials. Current research includes the development of a sample preparation protocol for explosive materials testing based on drop-on-demand technology. A quartz crystal microbalance and Raman spectroscopy are used to investigate droplet and sample uniformity and reproducibility. Results are compared to samples prepared using a drop and dry method. C1 [Holthoff, Ellen L.; Hankus, Mikella E.; Pellegrino, Paul M.] USA, Res Lab, RDRL SEE O, Adelphi, MD 20783 USA. RP Holthoff, EL (reprint author), USA, Res Lab, RDRL SEE O, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RI Hankus, Mikella/A-9005-2012 NR 9 TC 2 Z9 2 U1 0 U2 4 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-592-2 J9 PROC SPIE PY 2011 VL 8018 AR 80181F DI 10.1117/12.883451 PG 9 WC Optics; Physics, Applied SC Optics; Physics GA BXX76 UT WOS:000297515800046 ER PT S AU Pan, YL Hill, SC Pinnick, RG Santarpia, JL Baker, N Alvarez, B Ratnesar-Shumate, S Cottrell, B McKee, L AF Pan, Yong-Le Hill, Steven C. Pinnick, Ronald G. Santarpia, Joshua L. Baker, Neal Alvarez, Benjamin Ratnesar-Shumate, Shanna Cottrell, Brian McKee, Laura BE Fountain, AW Gardner, PJ TI Fluorescence spectra of bioaerosols exposed to ozone in a laboratory reaction chamber to simulate atmospheric processing SO CHEMICAL, BIOLOGICAL, RADIOLOGICAL, NUCLEAR, AND EXPLOSIVES (CBRNE) SENSING XII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XII CY APR 26-28, 2011 CL Orlando, FL SP SPIE DE fluorescence spectrum; bioaerosol; ozone; reaction chamber ID ORGANIC-CARBON; AEROSOL; PARTICLES; CLASSIFICATION; SPECTROMETER; SENSOR AB Laboratory measurements demonstrating the effects of ozone on aerosolized B. thuringiensis, as revealed by fluorescence spectra, are reported. The fluorescence emission peak around 330 nm (excited at 263nm) decreases somewhat in intensity and becomes slightly blue-shifted. Further, the fluorescence emission around 400 nm-550 nm is less affected by the ozone than is the 330 nm (tryptophan) peak. C1 [Pan, Yong-Le; Hill, Steven C.; Pinnick, Ronald G.] USA, Res Lab, Adelphi, MD 20783 USA. RP Pan, YL (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. NR 20 TC 2 Z9 2 U1 1 U2 10 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-592-2 J9 PROC SPIE PY 2011 VL 8018 AR 801804 DI 10.1117/12.883417 PG 7 WC Optics; Physics, Applied SC Optics; Physics GA BXX76 UT WOS:000297515800003 ER PT J AU Zheng, LQ Li, ZR Bourdo, S Watanabe, F Ryerson, CC Biris, AS AF Zheng, Liqiu Li, Zhongrui Bourdo, Shawn Watanabe, Fumiya Ryerson, Charles C. Biris, Alexandru S. TI Catalytic hydrogenation of graphene films SO CHEMICAL COMMUNICATIONS LA English DT Article ID REVERSIBLE HYDROGENATION; CARBON NANOTUBES; ELECTRON; GRAPHITE AB We developed a novel and facile method to hydrogenate graphene by using a conditioning catalyst upstream of the graphene sample to generate atomic hydrogen. C1 [Zheng, Liqiu; Li, Zhongrui; Bourdo, Shawn; Watanabe, Fumiya; Biris, Alexandru S.] Univ Arkansas, Nanotechnol Ctr, Little Rock, AR 72204 USA. [Ryerson, Charles C.] USA, Cold Reg Res & Engn Lab, Engn Res & Dev Ctr, Corps Engineers, Hanover, NH 03755 USA. RP Zheng, LQ (reprint author), Univ Arkansas, Nanotechnol Ctr, Little Rock, AR 72204 USA. EM lxzheng@ualr.edu; asbiris@ualr.edu RI Biris, Alexandru/A-8507-2010 FU DOD [W912HZ-09-2-0008]; Arkansas Science and Technology Authority (ASTA) [08-CAT-03] FX This research was partially supported by the DOD (Grant No. W912HZ-09-2-0008). Also the financial support from Arkansas Science and Technology Authority (ASTA) grant # 08-CAT-03 is highly appreciated. NR 16 TC 16 Z9 16 U1 0 U2 17 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1359-7345 J9 CHEM COMMUN JI Chem. Commun. PY 2011 VL 47 IS 4 BP 1213 EP 1215 DI 10.1039/c0cc03821k PG 3 WC Chemistry, Multidisciplinary SC Chemistry GA 704LY UT WOS:000286055700025 PM 21107460 ER PT J AU Zhao, L Gattas-Asfura, KM Xu, JM Patel, RA Dadlani, A Sillero-Mahinay, M Cushmore, M Rastogi, VK Shah, SS Leblanc, RM AF Zhao, Liang Gattas-Asfura, Kerim M. Xu, Jianmin Patel, Ravi A. Dadlani, Anup Sillero-Mahinay, Myrna Cushmore, Marie Rastogi, Vipin K. Shah, Saumil S. Leblanc, Roger M. TI Organophosphorus acid anhydrolase bio-template for the synthesis of CdS quantum dots SO CHEMICAL COMMUNICATIONS LA English DT Article ID ENZYME-BASED BIOSENSOR AB A direct conjugation of organophosphorus acid anhydrolase (OPAA) with CdS quantum dots was prepared via arrested precipitation within the enzyme matrix. The bio-conjugate was found not only to retain enzyme conformational structure but also to retain enzyme activity and be effective at detecting diisopropyl fluorophosphate (DFP) at the micro molar level. C1 [Zhao, Liang; Gattas-Asfura, Kerim M.; Xu, Jianmin; Patel, Ravi A.; Dadlani, Anup; Cushmore, Marie; Leblanc, Roger M.] Univ Miami, Dept Chem, Coral Gables, FL 33146 USA. [Sillero-Mahinay, Myrna] MSU Iligan Inst Technol, Dept Chem, Iligan 9200, Philippines. [Rastogi, Vipin K.] USA, BioDef Team, R&T Directorate, ECBC,AMSRD ECB RT BD, Aberdeen Proving Ground, MD 21010 USA. [Shah, Saumil S.] Biochem Team, Edgewood, MD 21040 USA. RP Leblanc, RM (reprint author), Univ Miami, Dept Chem, Coral Gables, FL 33146 USA. EM rml@miami.edu FU U.S. Army Research Office [DAAD 19-03-1-0131] FX The work was supported by a grant from the U.S. Army Research Office (DAAD 19-03-1-0131). We would like to thank Dr Jinhai Wang and Prof. Qun Huo from the Nanoscience Technology Center and the Department of Chemistry, University of Central Florida, Orlando, for assistance with the HR-TEM measurements. NR 11 TC 6 Z9 6 U1 1 U2 15 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1359-7345 J9 CHEM COMMUN JI Chem. Commun. PY 2011 VL 47 IS 25 BP 7242 EP 7244 DI 10.1039/c1cc10714c PG 3 WC Chemistry, Multidisciplinary SC Chemistry GA 777KC UT WOS:000291613400068 PM 21597641 ER PT J AU Chung, MK Severin, K Lee, SJ Waters, ML Gagne, MR AF Chung, Mee-Kyung Severin, Kay Lee, Stephen J. Waters, Marcey L. Gagne, Michel R. TI Constitutionally selective amplification of multicomponent 84-membered macrocyclic hosts for (-)-cytidine center dot H+ SO CHEMICAL SCIENCE LA English DT Article ID DYNAMIC COMBINATORIAL LIBRARIES; DIASTEREOSELECTIVE AMPLIFICATION; SYSTEMS CHEMISTRY; BUILDING-BLOCKS; GUEST BINDING; RECEPTORS; DISCOVERY AB Mixtures of dipeptide monomers create stereochemically and constitutionally complex dynamic libraries of potential receptors. When (-)-cytidine was utilized as guest an 84-membered cyclic host was amplified (70-175 fold) from a nearly undetectable initial concentration. Only the specified diastereomeric combination of the two chiral building blocks yielded a dynamic library from which the macrocyclic receptor could be amplified. C1 [Chung, Mee-Kyung; Waters, Marcey L.; Gagne, Michel R.] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA. [Severin, Kay] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland. [Lee, Stephen J.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Gagne, MR (reprint author), Univ N Carolina, Dept Chem, CB 3290, Chapel Hill, NC 27599 USA. EM mgagne@unc.edu FU Defense Threat Reduction Agency (DTRA) [W911NF04D0004] FX M.R.G. and M. L. W. thank the Defense Threat Reduction Agency (DTRA) for support (W911NF04D0004), S.J.L. thanks the Army Research Office, and K. S. thanks the Swiss National Science Foundation and EPFL for kind support. NR 30 TC 34 Z9 34 U1 1 U2 13 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2041-6520 J9 CHEM SCI JI Chem. Sci. PY 2011 VL 2 IS 4 BP 744 EP 747 DI 10.1039/c0sc00548g PG 4 WC Chemistry, Multidisciplinary SC Chemistry GA 735BE UT WOS:000288387600024 ER PT J AU Luo, YT Guo, JC Wang, CS Chu, DR AF Luo, Yanting Guo, Juchen Wang, Chunsheng Chu, Deryn TI An Acrylate-Polymer-Based Electrolyte Membrane for Alkaline Fuel Cell Applications SO CHEMSUSCHEM LA English DT Article DE energy conversion; fuel cells; membranes; polymer electrolytes; polymerization ID ANION-EXCHANGE MEMBRANE; MINIEMULSION POLYMERIZATION; VINYLBENZYL CHLORIDE; RECENT PROGRESS; PERFORMANCE; METHACRYLATE; COPOLYMER; IONOMERS; SYSTEMS; AMFCS C1 [Luo, Yanting; Guo, Juchen; Wang, Chunsheng] Univ Maryland, College Pk, MD 20742 USA. [Chu, Deryn] USA, Sensors & Electron Device Directorate, Res Lab, Adelphi, MD 20783 USA. RP Luo, YT (reprint author), Univ Maryland, College Pk, MD 20742 USA. EM cswang@umd.edu RI Wang, Chunsheng/H-5767-2011 OI Wang, Chunsheng/0000-0002-8626-6381 FU Office of Naval Research [N000140810717]; Army Research Lab [W911NF0920007]; Army Research Office [W911NF0910028] FX This work was supported by the Office of Naval Research (N000140810717), the Army Research Lab (W911NF0920007), and the Army Research Office (W911NF0910028). The authors are grateful to Prof. P. Kofinas at the University of Maryland for the technical support. NR 37 TC 12 Z9 12 U1 2 U2 32 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1864-5631 J9 CHEMSUSCHEM JI ChemSusChem PY 2011 VL 4 IS 11 BP 1557 EP 1560 DI 10.1002/cssc.201100287 PG 4 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY SC Chemistry; Science & Technology - Other Topics GA 847XB UT WOS:000297004900005 PM 21805679 ER PT S AU Thaler, A Gupta, A Cohen, SP AF Thaler, Adam Gupta, Anita Cohen, Steven P. BE Clark, MR Treisman, GJ TI Cannabinoids for Pain Management SO CHRONIC PAIN AND ADDICTION SE Advances in Psychosomatic Medicine LA English DT Article; Book Chapter ID RANDOMIZED CONTROLLED-TRIAL; PLACEBO-CONTROLLED TRIAL; CHRONIC NEUROPATHIC PAIN; MULTIPLE-SCLEROSIS CAMS; DOUBLE-BLIND; POSTOPERATIVE PAIN; MEDICINAL EXTRACTS; CROSSOVER TRIAL; SPASTICITY; EFFICACY AB Cannabinoids have been used for thousands of years to provide relief from suffering, but only recently have they been critically evaluated in clinical trials. This review provides an in-depth examination of the evidence supporting cannabinoids in various pain states, along with an overview of potential adverse effects. In summary, there is strong evidence for a moderate analgesic effect in peripheral neuropathic and central pain conditions, and conflicting evidence for their use in nociceptive pain For spasticity, most controlled studies demonstrate significant improvement. Adverse effects are not uncommon with cannabinoids, though most are not serious and self-limiting. In view of the limited effect size and low but not inconsequential risk of serious adverse events, cannabinoids should be employed as analgesics only when safer and more effective medication trials have failed, or as part of a multimodal treatment regimen. Copyright (C) 2011 S Karger AG, Basel C1 [Thaler, Adam; Gupta, Anita] Univ Penn, Sch Med, Pain Management Div, Dept Anesthesiol, Philadelphia, PA 19104 USA. [Cohen, Steven P.] Johns Hopkins Sch Med, Pain Management Div, Dept Anesthesiol & Crit Care Med, Baltimore, MD USA. [Cohen, Steven P.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. RP Cohen, SP (reprint author), Johns Hopkins Pain Management Div, 550 N Broadway,Suite 301, Baltimore, MD 21029 USA. NR 56 TC 10 Z9 10 U1 1 U2 7 PU KARGER PI BASEL PA POSTFACH, CH-4009 BASEL, SWITZERLAND SN 0065-3268 BN 978-3-8055-9725-8 J9 ADV PSYCHOSOM MED JI Adv.Psychosom.Med. PY 2011 VL 30 BP 125 EP 138 PG 14 WC Anesthesiology; Substance Abuse; Clinical Neurology; Psychiatry SC Anesthesiology; Substance Abuse; Neurosciences & Neurology; Psychiatry GA BUX72 UT WOS:000290637800007 PM 21508629 ER PT S AU Cohen, SP Liao, W Gupta, A Plunkett, A AF Cohen, Steven P. Liao, Wesley Gupta, Anita Plunkett, Anthony BE Clark, MR Treisman, GJ TI Ketamine in Pain Management SO CHRONIC PAIN AND ADDICTION SE Advances in Psychosomatic Medicine LA English DT Article; Book Chapter ID LOW-DOSE KETAMINE; RECEPTOR ANTAGONIST KETAMINE; ORAL DEXTROMETHORPHAN TREATMENT; PATIENT-CONTROLLED ANALGESIA; PREDICTIVE RESPONSE TOOL; CHRONIC NEUROPATHIC PAIN; TERMINAL CANCER PAIN; SPINAL-CORD-INJURY; INTRAVENOUS KETAMINE; DOUBLE-BLIND AB Ketamine is an N-methyl-D-aspartate receptor antagonist that has been in clinical use in the USA for over 30 years. Its ability to provide profound analgesia and amnesia while maintaining spontaneous respiration makes it an ideal medication for procedure-related pain and trauma. In the chronic pain arena, its use continues to evolve There is strong evidence to support its short-term use for neuropathic and nociceptive pain, and conflicting evidence for preemptive analgesia. Its potential ability to prevent 'windup' and, possibly, 'reboot' aberrant neurologic pathways in neuropathic and central pain states has generated intense interest. However, the long-term use of ketamine for chronic neuropathic pain is limited by its side effect profile, and is largely anecdotal. More research is needed to better ascertain its long-term efficacy and side effects, to determine the ideal candidates for sustained treatment and to develop means of exploiting the antinociceptive properties of ketamine while minimizing the adverse effects. Copyright (C) 2011 S Karger AG, Basel C1 [Cohen, Steven P.; Liao, Wesley] Johns Hopkins Sch Med, Pain Management Div, Dept Anesthesiol & Crit Care Med, Baltimore, MD USA. [Gupta, Anita] Univ Penn, Sch Med, Pain Management Div, Dept Anesthesiol, Philadelphia, PA 19104 USA. [Plunkett, Anthony] Walter Reed Army Med Ctr, Dept Surg, Anesthesia Serv, Washington, DC 20307 USA. RP Cohen, SP (reprint author), Johns Hopkins Pain Management Div, 550 N Broadway,Suite 301, Baltimore, MD 21029 USA. NR 118 TC 11 Z9 14 U1 1 U2 7 PU KARGER PI BASEL PA POSTFACH, CH-4009 BASEL, SWITZERLAND SN 0065-3268 BN 978-3-8055-9725-8 J9 ADV PSYCHOSOM MED JI Adv.Psychosom.Med. PY 2011 VL 30 BP 139 EP 161 PG 23 WC Anesthesiology; Substance Abuse; Clinical Neurology; Psychiatry SC Anesthesiology; Substance Abuse; Neurosciences & Neurology; Psychiatry GA BUX72 UT WOS:000290637800008 PM 21508630 ER PT J AU Crowell, HP Davis, IS AF Crowell, Harrison Philip Davis, Irene S. TI Gait retraining to reduce lower extremity loading in runners SO CLINICAL BIOMECHANICS LA English DT Article DE Feedback; Loading rate; Stress fracture; Tibial acceleration ID TIBIAL STRESS-FRACTURE; GROUND REACTION FORCE; KNOWLEDGE; FEEDBACK; INJURIES; ACQUISITION; SOLDIERS; FOOTWEAR; THERAPY; DEVICE AB Background: Tibial stress fractures, which are among the most common running related injuries, have been associated with increased lower extremity loading (i.e., peak positive acceleration of the tibia, vertical force impact peak, and average and instantaneous vertical force loading rates) during initial contact. This study was conducted to evaluate the efficacy of a gait retraining program designed to reduce this loading during running and to assess the short-term persistence of these reductions. Methods: Ten runners (six females and four males) with peak positive tibial acceleration greater than 8 g, measured in an initial screening, participated in the retraining program. During the retraining sessions, subjects ran on a treadmill and received real-time visual feedback from an accelerometer attached to their distal tibias. Tibial acceleration and vertical ground reaction force data were collected from subjects during overground data collection sessions held pre-training, post-training, and at a 1-month follow-up. Findings: Peak positive acceleration of the tibia, vertical force impact peak, and average and instantaneous vertical force loading rates were all reduced immediately following the gait retraining. The decrease in tibial acceleration was nearly 50%. The reductions in vertical force loading rates and vertical force impact peak were approximately 30% and 20%, respectively. These reductions were maintained at the 1-month follow-up. Interpretation: Subjects were able to run with reduced tibial acceleration and vertical force loading immediately following completion of the gait retraining program and at the 1-month follow-up evaluation. This may reduce their risk of stress fractures. Published by Elsevier Ltd. C1 [Crowell, Harrison Philip] USA, Res Lab, Human Res & Engn Directorate, RDRL HRS B, Aberdeen Proving Ground, MD 21005 USA. [Davis, Irene S.] Univ Delaware, Dept Phys Therapy, Newark, DE USA. [Davis, Irene S.] Drayer Phys Therapy Inst, Hummelstown, PA USA. RP Crowell, HP (reprint author), USA, Res Lab, Human Res & Engn Directorate, RDRL HRS B, Aberdeen Proving Ground, MD 21005 USA. EM harrison.philip.crowell@us.army.mil FU DOD [W911NF-05-1-0097, X81XWH-07-1-0395]; NIH [R01HD050679, 1-S10-RR022396] FX The authors would like to acknowledge the research assistants and students of the Motion Analysis Laboratory at the University of Delaware for their assistance with data collections. This research was funded in part by the following grants: DOD W911NF-05-1-0097, DOD X81XWH-07-1-0395, NIH R01HD050679, and NIH 1-S10-RR022396. The organizations that funded this research encourage publication of the results. NR 40 TC 83 Z9 83 U1 2 U2 59 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0268-0033 J9 CLIN BIOMECH JI Clin. Biomech. PD JAN PY 2011 VL 26 IS 1 BP 78 EP 83 DI 10.1016/j.clinbiomech.2010.09.003 PG 6 WC Engineering, Biomedical; Orthopedics; Sport Sciences SC Engineering; Orthopedics; Sport Sciences GA 718GZ UT WOS:000287110400012 PM 20888675 ER PT J AU Cohen, SP Kapoor, SG Anderson-Barnes, VC McHenry, M Nguyen, C Rao, D Plunkett, A AF Cohen, Steven P. Kapoor, Shruti G. Anderson-Barnes, Victoria C. McHenry, Marie Nguyen, Conner Rao, Dinesh Plunkett, Anthony TI Noncardiac Chest Pain During War SO CLINICAL JOURNAL OF PAIN LA English DT Article DE combat; etiology; nonbattle injury; noncardiac chest pain; war ID OPERATION-IRAQI-FREEDOM; QUALITY-OF-LIFE; HEALTH-CARE; RISK-FACTORS; CHILDHOOD ADVERSITY; NATURAL-HISTORY; BACK-PAIN; DISORDERS; RETURN; EPIDEMIOLOGY AB Objectives: Noncardiac chest pain (NCCP) has emerged as one of the biggest challenges facing military healthcare providers. The objectives of this study are to determine disease burden and diagnostic breakdown of NCCP, and to identify factors associated with return-to-duty (RTD). Methods: Data were prospectively collected from the Deployed Warrior Medical Management Center in Germany on 1935 service and nonservice members medically evacuated out of Operations Iraqi and Enduring Freedom for a primary diagnosis of NCCP between 2004 and 2007. Electronic medical records were reviewed to examine the effect myriad factors had on RTD. Results: One thousand nine hundred thirty-five personnel were medically evacuated with a diagnosis of NCCP, of whom 92% were men, 70% were in the Army, and 79% sustained their injury in Iraq. Fifty-eight percent returned to duty. The most common causes were musculoskeletal (23.4%), unknown (23%), cardiac (21%), pulmonary (13.9%), and gastrointestinal (11.9%). Factors associated with a positive outcome were being a commissioned officer [ adjusted odds ratio (OR) 1.87, P = 0.009]; serving in the navy (OR 2.25, P = 0.051); having a noncardiac etiology, including gastrointestinal (adjusted OR 5.65, P < 0.001), musculoskeletal (OR 4.19, P < 0.001), pulmonary (OR 1.80, P = 0.018), psychiatric (OR 2.11, P = 0.040), or neuropathic (OR 5.05, P = 0.040) causes; smoking history (OR 1.54, P = 0.005); and receiving no treatment for chest pain (OR 2.17, P = 0.006). Covariates associated with a decreased likelihood of RTD were service in Iraq (OR 0.68, P = 0.029) and treatment with opioids (OR 0.59, P = 0.006) or adjuvants (OR 0.61, P = 0.026). Conclusions: NCCP represents a significant cause of soldier attrition during combat operations, but is associated with the highest RTD rate among any diagnostic category. Among various causes, gastrointestinal is associated with the highest RTD rate. C1 [Cohen, Steven P.; Kapoor, Shruti G.] Johns Hopkins Sch Med, Dept Anesthesiol, Baltimore, MD USA. [Rao, Dinesh] Walter Reed Army Med Ctr, Natl Capital Consortium Program, Bethesda, MD USA. [Plunkett, Anthony] Walter Reed Army Med Ctr, Anesthesia Serv, Dept Surg, Bethesda, MD USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Cohen, Steven P.] Walter Reed Army Med Ctr, Dept Surg, Bethesda, MD USA. [Anderson-Barnes, Victoria C.] Walter Reed Army Med Ctr, Dept Orthoped Surg & Rehabil, Bethesda, MD USA. [McHenry, Marie] Georgetown Univ, Sch Med, Washington, DC USA. [Nguyen, Conner] Landstuhl Reg Med Ctr, Dept Surg, Phys Med & Rehabil Serv, Landstuhl, Germany. RP Cohen, SP (reprint author), 550 North Broadway,Suite 301, Baltimore, MD 21029 USA. EM scohen40@jhmi.edu FU John P. Murtha Neuroscience and Pain Institute, Johnstown, PA; Army Regional Anesthesia and Pain Medicine Initiative, Washington, DC FX Funded in part by a Congressional Grant from the John P. Murtha Neuroscience and Pain Institute, Johnstown, PA; and the Army Regional Anesthesia and Pain Medicine Initiative, Washington, DC. These organizations played no role in the study design, data collection, or drafting of the manuscript. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. Disclosures/Conflicts of Interest: None. NR 43 TC 4 Z9 4 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0749-8047 J9 CLIN J PAIN JI Clin. J. Pain PD JAN PY 2011 VL 27 IS 1 BP 19 EP 26 DI 10.1097/AJP.0b013e3181f06b06 PG 8 WC Anesthesiology; Clinical Neurology SC Anesthesiology; Neurosciences & Neurology GA 694IJ UT WOS:000285289200003 PM 20842022 ER PT J AU Belanger, HG Proctor-Weber, Z Kretzmer, T Kim, M French, LM Vanderploeg, RD AF Belanger, Heather G. Proctor-Weber, Zoe Kretzmer, Tracy Kim, Michelle French, Louis M. Vanderploeg, Rodney D. TI Symptom Complaints Following Reports of Blast Versus Non-Blast Mild TBI: Does Mechanism of Injury Matter? SO CLINICAL NEUROPSYCHOLOGIST LA English DT Article DE TBI; Mild TBI; Post-traumatic stress disorder; Post-concussion syndrome; Blast ID TRAUMATIC BRAIN-INJURY; POSTTRAUMATIC-STRESS-DISORDER; PERSISTENT POSTCONCUSSIVE SYMPTOMS; NEUROPSYCHOLOGICAL PERFORMANCE; COGNITIVE DEFICITS; WAR VETERANS; HEAD-INJURY; IRAQ; AFGHANISTAN; CONCUSSION AB Patients with a reported history of mild traumatic brain injury (mild TBI) due to blast (n = 298) or non-blast (n = 92) mechanisms were asked to complete the Neurobehavioral Symptom Inventory (NSI) and the Post-traumatic Stress Disorder Checklist (PCL). Mechanism of injury did not account for a significant amount of variance in post-concussion symptom reporting overall, nor did severity of mild TBI (i.e., brief loss of consciousness versus only an alteration of consciousness). Symptom reporting was greater in those injured more than 1 month ago compared to those injured less than 1 month ago and in those reporting higher levels versus lower levels of PTSD symptoms. When examining specific symptoms, the only symptom that significantly varied between groups was hearing difficulty (with the blast-injured group reporting more severe difficulty with hearing). Findings suggest that greater symptom reporting is most strongly related to emotional distress. C1 [Belanger, Heather G.; Kretzmer, Tracy; Kim, Michelle; Vanderploeg, Rodney D.] James A Haley VA, Dept Mental Hlth & Behav Sci, Tampa, FL USA. [Belanger, Heather G.; Vanderploeg, Rodney D.] Univ S Florida, Dept Psychol, Tampa, FL 33620 USA. [Vanderploeg, Rodney D.] Univ S Florida, Dept Psychiat, Tampa, FL USA. [Proctor-Weber, Zoe] Bay Pines VA Healthcare Syst, Dept Mental Hlth & Behav Sci, Bay Pines, FL USA. [Belanger, Heather G.; French, Louis M.; Vanderploeg, Rodney D.] Def & Vet Brain Injury Ctr, Washington, DC USA. [French, Louis M.] Walter Reed Army Med Ctr, Dept Orthoped & Rehabil, Washington, DC 20307 USA. [French, Louis M.] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. RP Belanger, HG (reprint author), James A Haley Vet Hosp, Psychol Serv 116B, Tampa, FL 33612 USA. EM Heather.Belanger@va.gov RI Schueter, nicos/A-3625-2014 FU Department of Veterans Affairs; Veterans Health Administration (VHA); Defense and Veterans Brain Injury Center (DVBIC); James A. Haley Veterans Hospital FX The research reported here was supported by the Department of Veterans Affairs, Veterans Health Administration (VHA), and the Defense and Veterans Brain Injury Center (DVBIC). Further support was provided by the James A. Haley Veterans Hospital. The views expressed herein are those of the authors and do not necessarily reflect the views or the official policy of the Department of Army, Department of Defense, Department of Veterans Affairs, or U.S. Government. NR 45 TC 49 Z9 49 U1 1 U2 8 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1385-4046 J9 CLIN NEUROPSYCHOL JI Clin. Neuropsychol. PY 2011 VL 25 IS 5 BP 702 EP 715 DI 10.1080/13854046.2011.566892 PG 14 WC Psychology, Clinical; Clinical Neurology; Psychology SC Psychology; Neurosciences & Neurology GA 882JE UT WOS:000299559000002 PM 21512958 ER PT J AU Jones, A Ingram, MV AF Jones, Alvin Ingram, M. Victoria TI A Comparison of Selected MMPI-2 and MMPI-2-RF Validity Scales in Assessing Effort on Cognitive Tests in a Military Sample SO CLINICAL NEUROPSYCHOLOGIST LA English DT Article DE MMPI-2; Optimal Data analysis; MMPI-2-RF; Symptom validity tests ID FAKE-BAD-SCALE; HENRY-HEILBRONNER INDEX; TRAUMATIC BRAIN-INJURY; NEUROPSYCHOLOGICAL TESTS; FORENSIC SETTINGS; LEES-HALEY; METAANALYSIS; VALIDATION; DISABILITY; DISORDERS AB Using a relatively new statistical paradigm, Optimal Data Analysis (ODA; Yarnold & Soltysik, 2005), this research demonstrated that newly developed scales for the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) and MMPI-2 Restructured Form (MMPI-2-RF) specifically designed to assess over-reporting of cognitive and/or somatic symptoms were more effective than the MMPI-2 F-family of scales in predicting effort status on tests of cognitive functioning in a sample of 288 military members. ODA demonstrated that when all scales were performing at their theoretical maximum possible level of classification accuracy, the Henry Heilbronner Index (HHI), Response Bias Scale (RBS), Fake Bad Scale (FBS), and the Symptom Validity Scale (FBS-r) outperformed the F-family of scales on a variety of ODA indexes of classification accuracy, including an omnibus measure (effect strength total, EST) of the descriptive and prognostic utility of ODA models developed for each scale. Based on the guidelines suggested by Yarnold and Soltysik for evaluating effect strengths for ODA models, the newly developed scales had effects sizes that were moderate in size (37.66 to 45.68), whereas the F-family scales had effects strengths that ranged from weak to moderate (15.42 to 32.80). In addition, traditional analysis demonstrated that HHI, RBS, FBS, and FBS-R had large effect sizes (0.98 to 1.16) based on Cohen's (1988) suggested categorization of effect size when comparing mean scores for adequate versus inadequate effort groups, whereas F-family of scales had small to medium effect sizes (0.25 to 0.76). The MMPI-2-RF Infrequent Somatic Responses Scale (F-S) tended to perform in a fashion similar to F, the best performing F-family scale. C1 [Ingram, M. Victoria] Womack Army Med Ctr, Dept Behav Hlth, Ft Bragg, NC 28310 USA. [Jones, Alvin] Landstuhl Reg Med Ctr, Dept Behav Hlth, Landstuhl, Germany. RP Ingram, MV (reprint author), Womack Army Med Ctr, Dept Behav Hlth, 2817 Riley Rd,Bldg 4-2817, Ft Bragg, NC 28310 USA. EM victoria.ingram@amedd.army.mil NR 38 TC 16 Z9 16 U1 2 U2 7 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1385-4046 J9 CLIN NEUROPSYCHOL JI Clin. Neuropsychol. PY 2011 VL 25 IS 7 BP 1207 EP 1227 DI 10.1080/13854046.2011.600726 PG 21 WC Psychology, Clinical; Clinical Neurology; Psychology SC Psychology; Neurosciences & Neurology GA 882JJ UT WOS:000299559600008 PM 21902565 ER PT J AU Dretsch, MN Tipples, J AF Dretsch, Michael N. Tipples, Jason TI Sex differences moderate decision making behaviour in high impulsive sensation seekers SO COGNITION & EMOTION LA English DT Article DE Emotional decision making; Sex differences; Sensation seeking; Impulsivity ID PREFRONTAL CORTEX; FUTURE CONSEQUENCES; PERSONALITY; INSENSITIVITY; DEFICITS; SEEKING; REWARD; TASKS; WOMEN AB We tested whether individuals with high levels of impulsive sensation seeking learn to choose advantageously in a specific decision-making context. One hundred twenty-eight participants (73 female) completed a neuropsychological task, the variant version of the Iowa Gambling Task (vIGT; Bechara, Tranel, Damasio, 2000), in which individuals must select cards from decks that offer high initial losses if they are to eventually make a profit. The selection from decks of cards that led to the highest profit as the task progressed was higher in high, compared to low, impulsive sensation seekers. However, learning to choose advantageously was moderated by sex of participant. Specifically, compared to females, male high impulsive sensation seekers learned more quickly to make consistent selections from the advantageous decks despite the large immediate losses. Overall, the data support the hypothesis that insensitivity to loss due to impulsive sensation seeking can lead to financial gain. C1 [Dretsch, Michael N.; Tipples, Jason] Univ Hull, Kingston Upon Hull HU6 7RX, N Humberside, England. RP Dretsch, MN (reprint author), USA, Aeromed Res Lab, 6901 Farrell Rd, Ft Rucker, AL USA. EM michael.dretsch@us.army.mil RI Tipples, Jason/H-3082-2015 NR 21 TC 2 Z9 2 U1 2 U2 10 PU PSYCHOLOGY PRESS PI HOVE PA 27 CHURCH RD, HOVE BN3 2FA, EAST SUSSEX, ENGLAND SN 0269-9931 J9 COGNITION EMOTION JI Cogn. Emot. PY 2011 VL 25 IS 1 BP 149 EP 155 AR PII 932217569 DI 10.1080/02699931003638200 PG 7 WC Psychology, Experimental SC Psychology GA 714OB UT WOS:000286817800013 PM 21432662 ER PT J AU Adcock, JM Stein, SL AF Adcock, James M. Stein, Sarah L. BA Adcock, JM Stein, SL BF Adcock, JM Stein, SL TI What Is a Cold Case and How Did We Get Here? SO COLD CASES: AN EVALUATION MODEL WITH FOLLOW-UP STRATEGIES FOR INVESTIGATORS SE Advances in Police Theory and Practice LA English DT Article; Book Chapter C1 [Adcock, James M.] US Army, New Haven, CT USA. [Adcock, James M.] Chief Deputy Coroner Invest Richland Cty, Columbia, SC USA. [Adcock, James M.] Univ New Haven, Criminal Justice Program, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Forens Sci Program, New Haven, CT USA. [Adcock, James M.] Invest Serv Program, New Haven, CT USA. [Adcock, James M.] Adv Invest Courses Forens Sci Grad Program, New Haven, CT USA. [Adcock, James M.] Coppin State Univ, Dept Criminal Justice, Baltimore, MD USA. Univ New Haven, Henry C Lee Inst Forens Sci, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Cold Case Workshop, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Inst Death Invest & Managing Invest Proc, New Haven, CT USA. [Adcock, James M.] AAFS, New Haven, CT USA. [Stein, Sarah L.] Connecticut Police Dept, Storrs, CT USA. RP Adcock, JM (reprint author), Kaplan Univ, Online Criminal Justice Courses, Ft Lauderdale, FL 33309 USA. NR 11 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-2691-1 J9 ADV POLIC THEOR PRAC PY 2011 BP 3 EP 11 PG 9 WC Criminology & Penology SC Criminology & Penology GA BD6HB UT WOS:000362211800003 ER PT J AU Adcock, JM Stein, SL AF Adcock, James M. Stein, Sarah L. BA Adcock, JM Stein, SL BF Adcock, JM Stein, SL TI Understanding the Process of Homicide and Those Who Kill SO COLD CASES: AN EVALUATION MODEL WITH FOLLOW-UP STRATEGIES FOR INVESTIGATORS SE Advances in Police Theory and Practice LA English DT Article; Book Chapter C1 [Adcock, James M.] US Army, New Haven, CT USA. [Adcock, James M.] Chief Deputy Coroner Invest Richland Cty, Columbia, SC USA. [Adcock, James M.] Univ New Haven, Criminal Justice Program, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Forens Sci Program, New Haven, CT USA. [Adcock, James M.] Invest Serv Program, New Haven, CT USA. [Adcock, James M.] Adv Invest Courses Forens Sci Grad Program, New Haven, CT USA. [Adcock, James M.] Coppin State Univ, Dept Criminal Justice, Baltimore, MD USA. [Adcock, James M.] Univ New Haven, Henry C Lee Inst Forens Sci, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Cold Case Workshop, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Inst Death Invest & Managing Invest Proc, New Haven, CT USA. [Adcock, James M.] AAFS, New Haven, CT USA. [Stein, Sarah L.] Connecticut Police Dept, New Haven, CT USA. RP Adcock, JM (reprint author), Kaplan Univ, Online Criminal Justice Courses, Ft Lauderdale, FL 33309 USA. NR 24 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-2691-1 J9 ADV POLIC THEOR PRAC PY 2011 BP 13 EP 25 PG 13 WC Criminology & Penology SC Criminology & Penology GA BD6HB UT WOS:000362211800004 ER PT J AU Adcock, JM AF Adcock, James M. BA Adcock, JM Stein, SL BF Adcock, JM Stein, SL TI Cold Cases An Evaluation Model with Follow-up Strategies for Investigators Introduction SO COLD CASES: AN EVALUATION MODEL WITH FOLLOW-UP STRATEGIES FOR INVESTIGATORS SE Advances in Police Theory and Practice LA English DT Editorial Material; Book Chapter C1 [Adcock, James M.] US Army, New Haven, CT USA. [Adcock, James M.] Chief Deputy Coroner Invest Richland Cty, Columbia, SC USA. [Adcock, James M.] Univ New Haven, Criminal Justice Program, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Forens Sci Program, New Haven, CT USA. [Adcock, James M.] Invest Serv Program, London, England. [Adcock, James M.] Adv Invest Courses Forens Sci Grad Program, London, England. [Adcock, James M.] Coppin State Univ, Dept Criminal Justice, Baltimore, MD USA. [Adcock, James M.] Univ New Haven, Henry C Lee Inst Forens Sci, New Haven, CT USA. Univ New Haven, Cold Case Workshop, New Haven, CT USA. Univ New Haven, Inst Death Invest & Managing Invest Proc, New Haven, CT USA. AAFS, New Haven, CT USA. RP Adcock, JM (reprint author), Kaplan Univ, Online Criminal Justice Courses, Ft Lauderdale, FL 33309 USA. EM jmadcock@jma-forensics.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-2691-1 J9 ADV POLIC THEOR PRAC PY 2011 BP XXI EP XXV PG 5 WC Criminology & Penology SC Criminology & Penology GA BD6HB UT WOS:000362211800002 ER PT J AU Adcock, JM Stein, SL AF Adcock, James M. Stein, Sarah L. BA Adcock, JM Stein, SL BF Adcock, JM Stein, SL TI Creating a Cold Case Squad (Concepts for Initialization) SO COLD CASES: AN EVALUATION MODEL WITH FOLLOW-UP STRATEGIES FOR INVESTIGATORS SE Advances in Police Theory and Practice LA English DT Article; Book Chapter C1 [Adcock, James M.] US Army, New Haven, CT USA. [Adcock, James M.] Chief Deputy Coroner Invest Richland Cty, Columbia, SC USA. [Adcock, James M.] Univ New Haven, Criminal Justice Program, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Forens Sci Program, New Haven, CT USA. [Adcock, James M.] Invest Serv Program, New Haven, CT USA. [Adcock, James M.] Adv Invest Courses Forens Sci Grad Program, New Haven, CT USA. [Adcock, James M.] Coppin State Univ, Dept Criminal Justice, Baltimore, MD USA. [Adcock, James M.] Univ New Haven, Henry C Lee Inst Forens Sci, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Cold Case Workshop, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Inst Death Invest & Managing Invest Proc, New Haven, CT USA. [Adcock, James M.] AAFS, New Haven, CT USA. [Stein, Sarah L.] Connecticut Police Dept, New Haven, CT USA. RP Adcock, JM (reprint author), Kaplan Univ, Online Criminal Justice Courses, Ft Lauderdale, FL 33309 USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-2691-1 J9 ADV POLIC THEOR PRAC PY 2011 BP 27 EP 37 PG 11 WC Criminology & Penology SC Criminology & Penology GA BD6HB UT WOS:000362211800005 ER PT J AU Adcock, JM Stein, SL AF Adcock, James M. Stein, Sarah L. BA Adcock, JM Stein, SL BF Adcock, JM Stein, SL TI The Cold Case Evaluation Model-Introduction and Phase I SO COLD CASES: AN EVALUATION MODEL WITH FOLLOW-UP STRATEGIES FOR INVESTIGATORS SE Advances in Police Theory and Practice LA English DT Article; Book Chapter AB The whole concept of writing this book hinged on the evaluation model we will describe in the next three chapters. The information in the earlier chapters was designed specifically to give the reader background information on cold cases, historical events, and an understanding of the times in relation to homicides and those who kill. In the chapters that follow the presentation of the model and information regarding the follow-up investigation will he documented. After introducing the philosophy behind the cold case evaluation model and description of the regimented structure, this chapter will delve into Phase I of the process. C1 [Adcock, James M.] US Army, New Haven, CT USA. [Adcock, James M.] Chief Deputy Coroner Invest Richland Cty, Columbia, SC USA. [Adcock, James M.] Univ New Haven, Criminal Justice Program, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Forens Sci Program, New Haven, CT USA. [Adcock, James M.] Invest Serv Program, New Haven, CT USA. [Adcock, James M.] Adv Invest Courses Forens Sci Grad Program, New Haven, CT USA. [Adcock, James M.] Coppin State Univ, Dept Criminal Justice, Baltimore, MD USA. [Adcock, James M.] Univ New Haven, Henry C Lee Inst Forens Sci, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Cold Case Workshop, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Inst Death Invest & Managing Invest Proc, New Haven, CT USA. [Adcock, James M.] AAFS, New Haven, CT USA. [Stein, Sarah L.] Connecticut Police Dept, New Haven, CT USA. RP Adcock, JM (reprint author), Kaplan Univ, Online Criminal Justice Courses, Ft Lauderdale, FL 33309 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-2691-1 J9 ADV POLIC THEOR PRAC PY 2011 BP 41 EP 56 PG 16 WC Criminology & Penology SC Criminology & Penology GA BD6HB UT WOS:000362211800006 ER PT J AU Adcock, JM Stein, SL AF Adcock, James M. Stein, Sarah L. BA Adcock, JM Stein, SL BF Adcock, JM Stein, SL TI The Cold Case Evaluation Model-Phase II SO COLD CASES: AN EVALUATION MODEL WITH FOLLOW-UP STRATEGIES FOR INVESTIGATORS SE Advances in Police Theory and Practice LA English DT Article; Book Chapter C1 [Adcock, James M.] US Army, New Haven, CT USA. [Adcock, James M.] Chief Deputy Coroner Invest Richland Cty, Columbia, SC USA. [Adcock, James M.] Univ New Haven, Criminal Justice Program, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Forens Sci Program, New Haven, CT USA. [Adcock, James M.] Invest Serv Program, New Haven, CT USA. [Adcock, James M.] Adv Invest Courses Forens Sci Grad Program, New Haven, CT USA. [Adcock, James M.] Coppin State Univ, Dept Criminal Justice, Baltimore, MD USA. [Adcock, James M.] Univ New Haven, Henry C Lee Inst Forens Sci, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Cold Case Workshop, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Inst Death Invest & Managing Invest Proc, New Haven, CT USA. [Adcock, James M.] AAFS, New Haven, CT USA. [Stein, Sarah L.] Connecticut Police Dept, New Haven, CT USA. RP Adcock, JM (reprint author), Kaplan Univ, Online Criminal Justice Courses, Ft Lauderdale, FL 33309 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-2691-1 J9 ADV POLIC THEOR PRAC PY 2011 BP 57 EP 68 PG 12 WC Criminology & Penology SC Criminology & Penology GA BD6HB UT WOS:000362211800007 ER PT J AU Adcock, JM Stein, SL AF Adcock, James M. Stein, Sarah L. BA Adcock, JM Stein, SL BF Adcock, JM Stein, SL TI The Cold Case Evaluation Model-Phases III and IV SO COLD CASES: AN EVALUATION MODEL WITH FOLLOW-UP STRATEGIES FOR INVESTIGATORS SE Advances in Police Theory and Practice LA English DT Article; Book Chapter C1 [Adcock, James M.] US Army, New Haven, CT USA. [Adcock, James M.] Chief Deputy Coroner Invest Richland Cty, Columbia, SC USA. [Adcock, James M.] Univ New Haven, Criminal Justice Program, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Forens Sci Program, New Haven, CT USA. [Adcock, James M.] Invest Serv Program, New Haven, CT USA. [Adcock, James M.] Adv Invest Courses Forens Sci Grad Program, New Haven, CT USA. [Adcock, James M.] Coppin State Univ, Dept Criminal Justice, Baltimore, MD USA. [Adcock, James M.] Univ New Haven, Henry C Lee Inst Forens Sci, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Cold Case Workshop, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Inst Death Invest & Managing Invest Proc, New Haven, CT USA. [Adcock, James M.] AAFS, New Haven, CT USA. [Stein, Sarah L.] Connecticut Police Dept, New Haven, CT USA. RP Adcock, JM (reprint author), Kaplan Univ, Online Criminal Justice Courses, Ft Lauderdale, FL 33309 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-2691-1 J9 ADV POLIC THEOR PRAC PY 2011 BP 69 EP 82 PG 14 WC Criminology & Penology SC Criminology & Penology GA BD6HB UT WOS:000362211800008 ER PT J AU Walter, R Stein, SL Adcock, JM AF Walter, Richard Stein, Sarah L. Adcock, James M. BA Adcock, JM Stein, SL BF Adcock, JM Stein, SL TI Suspect Identification Using Pre-, Peri-, and Post-Offense Behaviors SO COLD CASES: AN EVALUATION MODEL WITH FOLLOW-UP STRATEGIES FOR INVESTIGATORS SE Advances in Police Theory and Practice LA English DT Article; Book Chapter C1 [Stein, Sarah L.] Connecticut Police Dept, New Haven, CT USA. [Adcock, James M.] US Army, New Haven, CT USA. [Adcock, James M.] Chief Deputy Coroner Invest Richland Cty, Columbia, SC USA. [Adcock, James M.] Univ New Haven, Criminal Justice Program, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Forens Sci Program, New Haven, CT USA. [Adcock, James M.] Invest Serv Program, New Haven, CT USA. [Adcock, James M.] Adv Invest Courses Forens Sci Grad Program, New Haven, CT USA. [Adcock, James M.] Coppin State Univ, Dept Criminal Justice, Baltimore, MD USA. [Adcock, James M.] Univ New Haven, Henry C Lee Inst Forens Sci, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Cold Case Workshop, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Inst Death Invest & Managing Invest Proc, New Haven, CT USA. [Adcock, James M.] AAFS, New Haven, CT USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-2691-1 J9 ADV POLIC THEOR PRAC PY 2011 BP 103 EP 123 PG 21 WC Criminology & Penology SC Criminology & Penology GA BD6HB UT WOS:000362211800010 ER PT J AU Adcock, JM Stein, SL AF Adcock, James M. Stein, Sarah L. BA Adcock, JM Stein, SL BF Adcock, JM Stein, SL TI Interview and Interrogation Issues and Concerns Relating to Cold Cases SO COLD CASES: AN EVALUATION MODEL WITH FOLLOW-UP STRATEGIES FOR INVESTIGATORS SE Advances in Police Theory and Practice LA English DT Editorial Material; Book Chapter C1 [Adcock, James M.] US Army, New Haven, CT USA. [Adcock, James M.] Chief Deputy Coroner Invest Richland Cty, Columbia, SC USA. [Adcock, James M.] Univ New Haven, Criminal Justice Program, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Forens Sci Program, New Haven, CT USA. [Adcock, James M.] Invest Serv Program, New Haven, CT USA. [Adcock, James M.] Adv Invest Courses Forens Sci Grad Program, New Haven, CT USA. [Adcock, James M.] Coppin State Univ, Dept Criminal Justice, Baltimore, MD USA. [Adcock, James M.] Univ New Haven, Henry C Lee Inst Forens Sci, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Cold Case Workshop, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Inst Death Invest & Managing Invest Proc, New Haven, CT USA. [Adcock, James M.] AAFS, New Haven, CT USA. [Stein, Sarah L.] Connecticut Police Dept, New Haven, CT USA. RP Adcock, JM (reprint author), Kaplan Univ, Online Criminal Justice Courses, Ft Lauderdale, FL 33309 USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-2691-1 J9 ADV POLIC THEOR PRAC PY 2011 BP 125 EP 141 PG 17 WC Criminology & Penology SC Criminology & Penology GA BD6HB UT WOS:000362211800011 ER PT J AU Adcock, JM Stein, SL AF Adcock, James M. Stein, Sarah L. BA Adcock, JM Stein, SL BF Adcock, JM Stein, SL TI Evaluation Reports and Legal Considerations SO COLD CASES: AN EVALUATION MODEL WITH FOLLOW-UP STRATEGIES FOR INVESTIGATORS SE Advances in Police Theory and Practice LA English DT Article; Book Chapter C1 [Adcock, James M.] US Army, New Haven, CT USA. [Adcock, James M.] Chief Deputy Coroner Invest Richland Cty, Columbia, SC USA. [Adcock, James M.] Univ New Haven, Criminal Justice Program, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Forens Sci Program, New Haven, CT USA. [Adcock, James M.] Invest Serv Program, New Haven, CT USA. [Adcock, James M.] Adv Invest Courses Forens Sci Grad Program, New Haven, CT USA. [Adcock, James M.] Coppin State Univ, Dept Criminal Justice, Baltimore, MD USA. [Adcock, James M.] Univ New Haven, Henry C Lee Inst Forens Sci, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Cold Case Workshop, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Inst Death Invest & Managing Invest Proc, New Haven, CT USA. [Adcock, James M.] AAFS, New Haven, CT USA. [Stein, Sarah L.] Connecticut Police Dept, New Haven, CT USA. RP Adcock, JM (reprint author), Kaplan Univ, Online Criminal Justice Courses, Ft Lauderdale, FL 33309 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-2691-1 J9 ADV POLIC THEOR PRAC PY 2011 BP 143 EP 156 PG 14 WC Criminology & Penology SC Criminology & Penology GA BD6HB UT WOS:000362211800012 ER PT J AU Adcock, JM Stein, SL AF Adcock, James M. Stein, Sarah L. BA Adcock, JM Stein, SL BF Adcock, JM Stein, SL TI Cold Cases An Evaluation Model with Follow-up Strategies for Investigators Conclusion SO COLD CASES: AN EVALUATION MODEL WITH FOLLOW-UP STRATEGIES FOR INVESTIGATORS SE Advances in Police Theory and Practice LA English DT Editorial Material; Book Chapter C1 [Adcock, James M.] US Army, New Haven, CT USA. [Adcock, James M.] Chief Deputy Coroner Invest Richland Cty, Columbia, SC USA. [Adcock, James M.] Univ New Haven, Criminal Justice Program, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Forens Sci Program, New Haven, CT USA. [Adcock, James M.] Invest Serv Program, New Haven, CT USA. [Adcock, James M.] Adv Invest Courses Forens Sci Grad Program, New Haven, CT USA. [Adcock, James M.] Coppin State Univ, Dept Criminal Justice, Baltimore, MD USA. [Adcock, James M.] Univ New Haven, Henry C Lee Inst Forens Sci, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Cold Case Workshop, New Haven, CT USA. [Adcock, James M.] Univ New Haven, Inst Death Invest & Managing Invest Proc, New Haven, CT USA. [Adcock, James M.] AAFS, New Haven, CT USA. [Stein, Sarah L.] Connecticut Police Dept, New Haven, CT USA. RP Adcock, JM (reprint author), Kaplan Univ, Online Criminal Justice Courses, Ft Lauderdale, FL 33309 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-2691-1 J9 ADV POLIC THEOR PRAC PY 2011 BP 157 EP 159 PG 3 WC Criminology & Penology SC Criminology & Penology GA BD6HB UT WOS:000362211800013 ER PT B AU Harvey, Z Potter, BK AF Harvey, Zach Potter, Benjamin K. BE Owens, BD Belmont, PJ TI PROSTHESES FOR MAJOR EXTREMITY AMPUTATIONS SO COMBAT ORTHOPEDIC SURGERY: LESSONS LEARNED IN IRAQ AND AFGHANISTAN LA English DT Article; Book Chapter ID TARGETED MUSCLE REINNERVATION; UPPER-LIMB AMPUTEES; ENERGY-EXPENDITURE; KNEE PROSTHESIS; WALKING; GAIT; REHABILITATION; SOCKET; DISARTICULATION; BIOMECHANICS C1 [Harvey, Zach; Potter, Benjamin K.] Walter Reed Army Med Ctr, Amputee Patient Care Program, Integrated Dept Orthopaed & Rehabil, Washington, DC 20307 USA. [Potter, Benjamin K.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. RP Harvey, Z (reprint author), Walter Reed Army Med Ctr, Amputee Patient Care Program, Integrated Dept Orthopaed & Rehabil, Washington, DC 20307 USA. NR 100 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE ROAD, THOROFARE, NJ 08086-9447 USA BN 978-1-55642-965-1 PY 2011 BP 221 EP 235 PG 15 WC Orthopedics; Surgery SC Orthopedics; Surgery GA BTZ12 UT WOS:000288484200023 ER PT J AU Sherburn, JA Nelson, DH Price, CD Slawson, TR AF Sherburn, Jesse A. Nelson, Donald H. Price, Carey D. Slawson, Thomas R. BE Papadrakakis, M Onate, E Schrefler, B TI MODELING OF AIRBLAST PROPAGATION THROUGH AN ENCLOSED STRUCTURE SO COMPUTATIONAL METHODS FOR COUPLED PROBLEMS IN SCIENCE AND ENGINEERING IV LA English DT Proceedings Paper CT 4th International Conference on Computational Methods for Coupled Problems in Science and Engineering (COUPLED PROBLEMS) CY JUN 20-22, 2011 CL Kos, GREECE SP Natl Tech Univ Athens, Int Ctr Numer Methods Engn (CIMNE), Tech Univ Catalonia (UPC), Univ Padova DE Fluid-Structure Interaction; CTH; DYSMAS; Confined Airblast ID BLAST; SHOCK AB The ability to model explosively formed shock waves propagating through a structure is of particular interest to engineers concerned with structural responses to blasts. Accurate peak pressure and impulse values are critical to understanding blast loads on structures and predicting the resulting structural behavior, but are sometimes difficult to determine analytically. Experiments are necessary to determine the true structural response, but the experiments alone may not identify all the details involved in an explosive event that may be important for design purposes. When tied to experiments, computational modeling of explosive events can be an invaluable tool for an engineer. The most difficult part of modeling structural response to a close-in explosive event is capturing the fluid-structure interaction of the resulting flow of the detonation products. In this paper, we compare the results of numerical simulations of an explosive experimental event in an enclosed structure, or "attic space", using two different computational codes, CTH and DYSMAS. Both adequately model the explosive event in attic space when compared to the experiment. We also compare the two codes' ability to produce explosive-induced pressure-time histories in the free field. The advantage of using a coupled code like DYSMAS is that structural response can be more accurately captured than by using a hydrocode like CTH alone. The differences between the two codes' ability to model the event are analyzed and described as well as a general description of the shock wave propagation in the attic space. C1 [Sherburn, Jesse A.; Nelson, Donald H.; Price, Carey D.; Slawson, Thomas R.] USA, Corps Engineers, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Sherburn, JA (reprint author), USA, Corps Engineers, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM jesse.a.sherbum@usace.army.mil; donald.h.nelson@usace.army.mil; carey.d.price@usace.army.mil; thomas.r.slawson@usace.army.mil NR 11 TC 0 Z9 0 U1 0 U2 2 PU INT CENTER NUMERICAL METHODS ENGINEERING PI 08034 BARCELONA PA GRAN CAPITAN, S-N, CAMPUS NORTE UPC, MODULO C1, 08034 BARCELONA, SPAIN BN 978-84-89925-78-6 PY 2011 BP 962 EP 973 PG 12 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Mathematics GA BDJ78 UT WOS:000313559700085 ER PT S AU McCain, KNS Ridings, JW Phelps, Q Hrabik, RA AF McCain, Kathryn N. S. Ridings, Joseph W. Phelps, Quinton Hrabik, Robert A. BE Michaletz, PH Travnichek, VH TI Population Trends of Flathead Catfish, Channel Catfish, and Blue Catfish in Impounded and Unimpounded Reaches of the Upper Mississippi River (1993-2007) SO CONSERVATION, ECOLOGY, AND MANAGEMENT OF CATFISH: THE SECOND INTERNATIONAL SYMPOSIUM, 2010 SE American Fisheries Society Symposium LA English DT Proceedings Paper CT 2nd International Catfish Symposium on Conservation, Ecology, and Management of Catfish, Catfish 2010 CY JUN 19-22, 2010 CL St Louis, MI SP AFS Educ Sect, AFS Fisheries Management Sect, US Fish & Wildlife Serv, Kansas Dept Wildlife & Pk, Missouri River Nat Resources Comm, Nebraska Game & Pk Commiss, AFS Missouri Chapter, Bass Pro Shops, Conservat Federat Missouri, MICRA, Smith Root Inc, Tennessee Wildlife Resources Agcy, AFS N Central Div, AFS N Central Div Rivers & Streams Tech Comm, AFS So Div, AFS Arkansas Chapter, AFS Dakota Chapter, AFS Georgia Chapter, AFS Illinois Chapter, AFS Iowa Chapter, AFS Kansas Chapter, AFS Minnesota Chapter, AFS Mississippi Chapter, AFS Nebraska Chapter, AFS Ohio Chapter, AFS S Carolina Chapter, AFS Tennessee Chapter, AFSTexas Chapter, AFS Virginia Chapter, AFS Wisconsin Chapter, Duke Energy, Minner Net Co Inc, Upper Mississippi River Conservat Comm, W Virginia Dept Nat Resources ID MANAGEMENT AB Using Long Term Resource Monitoring Program data collected from impounded (Pool 26) and unimpounded (Open River) reaches of the upper Mississippi River, we investigated population dynamics of flathead catfish Pylodictis olivaris, channel catfish Ictalurus punctatus, and blue catfish I. furcatus from random sites located in side channel border (SCB) and main channel border (MCB) habitats. Objectives were to (1) compare trends (1993-2007) of three catfishes collected in Pool 26 and Open River reaches of the upper Mississippi River, and (2) provide needed information to managers on population dynamics through time using a binary gear approach of active (i.e., daytime electrofishing) and passive gears (hoopnetting). Active gears resulted in a higher catch per unit effort (CPUE) of all catfishes in each habitat reach combination as compared to passive gears. Passive gears resulted in negligible catches of blue catfish and flathead catfishes (e.g., mean of <1 fish/net night). Catch per unit effort using active gear resulted in a greater number of channel catfish captured in Pool 26 compared to the Open River, with Open River SCB habitat having the lowest CPUE in most years. Blue catfish in the Open River had a higher CPUE using active gear as compared to Pool 26, with the Open River MCB having the greatest CPUE. Flathead catfish had a higher CPUE in MCB habitat compared to SCB habitat, with the Open River MCB having the highest CPUE in most years. However, declining trends in flathead catfish appears to be occurring in Open River habitats while trends in flathead catfish appear to be slightly increasing in Pool 26. The most common length-classes captured were substock and stock-sized fish regardless of habitat, species, or reach. Trends for channel catfish were easily determined due to high catch rates; however, more monitoring and enhanced sampling is needed to accurately assess flathead catfish and blue catfish trends and to accurately determine demographics for all three species. C1 [McCain, Kathryn N. S.] US Army Corps Engineers, Environm Planning Sect CEMVS PD E, St Louis, MO 63103 USA. [Ridings, Joseph W.; Phelps, Quinton; Hrabik, Robert A.] Missouri Dept Conservat, Open Rivers & Wetlands Field Stn, 3815 East Jackson Blvd, Jackson, MO 63755 USA. RP Ridings, JW (reprint author), Missouri Dept Conservat, Open Rivers & Wetlands Field Stn, 3815 East Jackson Blvd, Jackson, MO 63755 USA. EM joseph.ridings@mdc.mo.gov NR 22 TC 1 Z9 1 U1 0 U2 3 PU AMER FISHERIES SOC PI BETHESDA PA 5410 GROSVENOR LANE, STE 110, BETHESDA, MD 20814-2199 USA SN 0892-2284 BN 978-1-934874-25-7 J9 AM FISH S S JI Am. Fish. Soc. Symp. PY 2011 VL 77 BP 141 EP 153 PG 13 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA BG9SD UT WOS:000393725100012 ER PT S AU Miranda, LE Killgore, KJ AF Miranda, Leandro E. Killgore, K. Jack BE Michaletz, PH Travnichek, VH TI Catfish Spatial Distribution in the Free-Flowing Mississippi River SO CONSERVATION, ECOLOGY, AND MANAGEMENT OF CATFISH: THE SECOND INTERNATIONAL SYMPOSIUM, 2010 SE American Fisheries Society Symposium LA English DT Proceedings Paper CT 2nd International Catfish Symposium on Conservation, Ecology, and Management of Catfish, Catfish 2010 CY JUN 19-22, 2010 CL St Louis, MI SP AFS Educ Sect, AFS Fisheries Management Sect, US Fish & Wildlife Serv, Kansas Dept Wildlife & Pk, Missouri River Nat Resources Comm, Nebraska Game & Pk Commiss, AFS Missouri Chapter, Bass Pro Shops, Conservat Federat Missouri, MICRA, Smith Root Inc, Tennessee Wildlife Resources Agcy, AFS N Central Div, AFS N Central Div Rivers & Streams Tech Comm, AFS So Div, AFS Arkansas Chapter, AFS Dakota Chapter, AFS Georgia Chapter, AFS Illinois Chapter, AFS Iowa Chapter, AFS Kansas Chapter, AFS Minnesota Chapter, AFS Mississippi Chapter, AFS Nebraska Chapter, AFS Ohio Chapter, AFS S Carolina Chapter, AFS Tennessee Chapter, AFSTexas Chapter, AFS Virginia Chapter, AFS Wisconsin Chapter, Duke Energy, Minner Net Co Inc, Upper Mississippi River Conservat Comm, W Virginia Dept Nat Resources ID CHANNEL CATFISH; RELATIVE ABUNDANCE; FLATHEAD CATFISH; PATTERNS; ECOLOGY; MANAGEMENT; HABITATS; BIOLOGY; LENGTH; SCALES AB We examined spatial distribution of blue catfish Ictalurus furcatus, channel catfish I. punctatus, and flathead catfish Pylodictis olivaris at macro-, meso-, and microscales in the unimpounded Mississippi River between its mouth and the mouth of the Missouri River (river kilometer 1,847). Fish collections represented 1,309 trotlines fished at 154 river segments in 1997-2009. Blue catfish was the most abundant catfish species, followed by channel catfish and flathead catfish. At the macroscale level, we tested for longitudinal gradients along five a priori reaches ranging in length from 154 to 595 km. Blue catfish and flathead catfish generally decreased in upriver reaches, whereas channel catfish were abundant at the two extremes of the river span and least abundant in middle reaches. Species catch rates at the mesoscale level varied across nine habitat types with catch rates of blue catfish highest along natural banks; channel catfish highest in dikes, main channel edge, and gravel bars; and flathead catfish highest in articulated concrete mattresses/riprap and steep sand bars. Percentage contribution to variance in catch rate apportioned by each spatial scale differed across species but was always highest at the macroscale level, indicating greater spatial dependence at this scale. Site -specific mesoscale and microscale conditions account for local variability in abundances and are important in allocating effort in sampling programs. However, considering macroscale has the greatest influence over catfish populations, it is at this broad -scale level that management may be most effective. C1 [Miranda, Leandro E.] US Geol Survey, Mississippi Cooperat Fish & Wildlife Res Unit, POB 9691, Mississippi State, MS 39762 USA. [Killgore, K. Jack] US Army, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Miranda, LE (reprint author), US Geol Survey, Mississippi Cooperat Fish & Wildlife Res Unit, POB 9691, Mississippi State, MS 39762 USA. EM smiranda@cfr.msstate.edu FU Mississippi Valley Division of the U.S. Army Corps of Engineers; Ecosystem Management and Restoration Research Program FX This study was funded by the Mississippi Valley Division of the U.S. Army Corps of Engineers and the Ecosystem Management and Restoration Research Program. Assistance in field collections was provided by Jan Hoover, Steven George, William Lancaster, Bradley Lewis, Phil Kirk, Catherine Murphy, Neil Douglas, Krista Boysen, and Jay Collins. Permission to publish this document was made by the Chief of Engineers, U.S. Army Corps of Engineers. NR 35 TC 1 Z9 1 U1 0 U2 0 PU AMER FISHERIES SOC PI BETHESDA PA 5410 GROSVENOR LANE, STE 110, BETHESDA, MD 20814-2199 USA SN 0892-2284 BN 978-1-934874-25-7 J9 AM FISH S S JI Am. Fish. Soc. Symp. PY 2011 VL 77 BP 521 EP 534 PG 14 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA BG9SD UT WOS:000393725100043 ER PT S AU Castro, CA Wiederhold, BK AF Castro, Carl Andrew Wiederhold, Brenda K. BE Wiederhold, BK TI The Importance of Developing a Valid Definition of Mild Traumatic Brain Injury/Concussion SO COPING WITH BLAST-RELATED TRAUMATIC BRAIN INJURY IN RETURNING TROOPS: WOUNDS OF WAR III SE Nato Science for Peace and Security Series E-Human and Societal Dynamics LA English DT Proceedings Paper CT NATO Advanced Research Workshop on Wounds of War III - Coping with Blast-Related Traumatic Brain Injury in Returning Troops CY FEB 20-22, 2011 CL Vienna, AUSTRIA SP N Atlantic Treaty Org Sci Peace & Secur Programme, Interact Media Inst, Virtual Real Med Inst, Int Neurotrauma Res Org, Austrian Minist Def, US Army Med Res & Mat Command, Croatian Minist Hlth & Social Welfare, Austrian Workers Compensat Board, Virtual Real Med Ctr DE Traumatic Brain Injury; concussion; service members; veterans; PTSD; blast; post-concussive syndrome ID POSTTRAUMATIC-STRESS-DISORDER; POSTCONCUSSIVE SYMPTOMS; WAR VETERANS; IRAQ; INJURY; SOLDIERS; AFGHANISTAN; OUTCOMES AB A valid definition of a symptom-based injury requires five components - an event, a reaction, unique symptoms, impairment, and a time course. In the case of mild traumatic brain injury (mTBI) or concussion, existing clinical definitions lack one or several of these components, thus hindering proper clinical diagnosis and research into the mechanisms, cause and treatment of mTBI/concussion. Recommendations for addressing this lack of definition validation are discussed. C1 [Castro, Carl Andrew] US Army Med Res & Mat Command, Ft Detrick, MD USA. [Wiederhold, Brenda K.] Virtual Real Med Ctr, San Diego, CA USA. [Wiederhold, Brenda K.] Virtual Real Med Inst, Brussels, Belgium. RP Castro, CA (reprint author), Med Res & Mat Command, Ft Detrick, MD 21702 USA. EM carl.castro@us.army.mil NR 9 TC 0 Z9 0 U1 1 U2 2 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 1879-8268 BN 978-1-60750-797-0; 978-1-60750-796-3 J9 NATO SCI PEACE SEC PY 2011 VL 86 BP 3 EP 7 DI 10.3233/978-1-60750-797-0-3 PG 5 WC Public, Environmental & Occupational Health; Neurosciences SC Public, Environmental & Occupational Health; Neurosciences & Neurology GA BC1YQ UT WOS:000350552300002 ER PT S AU Lange, RT Brickell, TA Iverson, GL Parkinson, G Bhagwat, A French, LM AF Lange, Rael T. Brickell, Tracey A. Iverson, Grant L. Parkinson, Glenn Bhagwat, Aditya French, Louis M. BE Wiederhold, BK TI 12-month Outcome of Mild Traumatic Brain Injury and Polytrauma in US Military Service Members SO COPING WITH BLAST-RELATED TRAUMATIC BRAIN INJURY IN RETURNING TROOPS: WOUNDS OF WAR III SE Nato Science for Peace and Security Series E-Human and Societal Dynamics LA English DT Proceedings Paper CT NATO Advanced Research Workshop on Wounds of War III - Coping with Blast-Related Traumatic Brain Injury in Returning Troops CY FEB 20-22, 2011 CL Vienna, AUSTRIA SP N Atlantic Treaty Org Sci Peace & Secur Programme, Interact Media Inst, Virtual Real Med Inst, Int Neurotrauma Res Org, Austrian Minist Def, US Army Med Res & Mat Command, Croatian Minist Hlth & Social Welfare, Austrian Workers Compensat Board, Virtual Real Med Ctr DE postconcussion symptoms; mild Traumatic Brain Injury; military service members ID POSTTRAUMATIC-STRESS-DISORDER; PENETRATING HEAD-INJURY; PERSISTENT POSTCONCUSSIVE SYMPTOMS; OPERATION IRAQI FREEDOM; MENTAL-HEALTH PROBLEMS; ENDURING FREEDOM; CHRONIC PAIN; VETERANS; AFGHANISTAN; BLAST AB This study examined 12-month outcome following polytrauma and mild Traumatic Brain Injury (MTBI) in injured service members who were evaluated at the Walter Reed Army Medical Center following injuries sustained in combat theater during Operations Iraqi Freedom or Enduring Freedom (OIF/OEF). Patients (N=48) completed the Neurobehavioral Symptom Inventory within 2 months of injury (M=15.9 days, SD=13.6) and a telephone interview at 12 months post injury (M=13.1, SD=0.8). More than half of the sample met DSM-IV criteria for Postconcussional Disorder within 2 months (54.2%) and 12 months post injury (55.6%). Over time, 20.8% showed an improvement of symptoms, 16.7% worsened, and 33.3% had persistent symptoms. At 12 months, most were on active duty (79.2%), reported that they were satisfied with life (81.3%), and indicated that their health status was either "excellent," "very good," or "good" (66.7%). However, a substantial percentage reported that they continued to take medications (81.3%), experienced bodily pain (72.9%), needed help with daily activities (29.2%), and were currently in treatment with a mental health professional (39.6%). A small percentage reported that they had recently had suicidal or homicidal thoughts (10.4%). Extended follow-up is recommended for service members who sustain an MTBI in the context of polytrauma. C1 [Lange, Rael T.; Parkinson, Glenn; Bhagwat, Aditya; French, Louis M.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Lange, Rael T.; Iverson, Grant L.] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada. [French, Louis M.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Lange, RT (reprint author), Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Bldg 1,Room B207,6900 Georgia Ave NW, Washington, DC 20307 USA. EM rlange@dvbic.org NR 59 TC 2 Z9 2 U1 0 U2 1 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 1879-8268 BN 978-1-60750-797-0; 978-1-60750-796-3 J9 NATO SCI PEACE SEC PY 2011 VL 86 BP 171 EP 186 DI 10.3233/978-1-60750-797-0-171 PG 16 WC Public, Environmental & Occupational Health; Neurosciences SC Public, Environmental & Occupational Health; Neurosciences & Neurology GA BC1YQ UT WOS:000350552300018 ER PT J AU Mondello, S Papa, L Buki, A Bullock, MR Czeiter, E Tortella, FC Wang, KK Hayes, RL AF Mondello, Stefania Papa, Linda Buki, Andras Bullock, M. Ross Czeiter, Endre Tortella, Frank C. Wang, Kevin K. Hayes, Ronald L. TI Neuronal and glial markers are differently associated with computed tomography findings and outcome in patients with severe traumatic brain injury: a case control study SO CRITICAL CARE LA English DT Article DE Traumatic Brain Injury; Biomarkers; Diagnostic; Outcome; Computed tomography ID SEVERE HEAD-INJURY; SERUM; PROTEIN; DAMAGE; PREDICTION; MODERATE AB Introduction: Authors of several studies have studied biomarkers and computed tomography (CT) findings in the acute phase after severe traumatic brain injury (TBI). However, the correlation between structural damage as assessed by neuroimaging and biomarkers has not been elucidated. The aim of this study was to investigate the relationships among neuronal (Ubiquitin carboxy-terminal hydrolase L1 [UCH-L1]) and glial (glial fibrillary acidic protein [GFAP]) biomarker levels in serum, neuroradiological findings and outcomes after severe TBI. Methods: The study recruited patients from four neurotrauma centers. Serum samples for UCH-L1 and GFAP were obtained at the time of hospital admission and every 6 hours thereafter. CT scans of the brain were obtained within 24hrs of injury. Outcome was assessed by Glasgow Outcome Scale (GOS) at discharge and at 6 months. Results: 81 severe TBI patients and 167 controls were enrolled. The mean serum levels of UCH-L1 and GFAP were higher (p < 0.001) in TBI patients compared to controls. UCH-L1 and GFAP serum levels correlated significantly with Glasgow Coma Scale (GCS) and CT findings. GFAP levels were higher in patients with mass lesions than in those with diffuse injury (2.95 +/- 0.48 ng/ml versus 0.74 +/- 0.11 ng/ml) while UCH-L1 levels were higher in patients with diffuse injury (1.55 +/- 0.18 ng/ml versus 1.21 +/- 0.15 ng/ml, p = 0.0031 and 0.0103, respectively). A multivariate logistic regression showed that UCH-L1 was the only independent predictor of death at discharge [adjusted odds ratios 2.95; 95% confidence interval, 1.46-5.97], but both UCH-L1 and GFAP levels strongly predicted death 6 months post-injury. Conclusions: Relationships between structural changes detected by neuroimaging and biomarkers indicate each biomarker may reflect a different injury pathway. These results suggest that protein biomarkers could provide better characterization of subjects at risk for specific types of cellular damage than that obtained with neuroimaging alone, as well as provide valuable information about injury severity and outcome after severe TBI. C1 [Mondello, Stefania; Hayes, Ronald L.] Univ Florida, Dept Anesthesiol, Gainesville, FL 32610 USA. [Mondello, Stefania] Banyan Biomarkers Inc, Ctr Innovat Res, Clin Dept, Alachua, FL 32615 USA. [Papa, Linda] Orlando Reg Med Ctr Inc, Dept Emergency Med, Orlando, FL 32806 USA. [Buki, Andras; Czeiter, Endre] Univ Pecs, Dept Neurosurg, H-7624 Pecs, Hungary. [Bullock, M. Ross] Univ Miami, Dept Neurosurg, Miami, FL 33136 USA. [Tortella, Frank C.] Walter Reed Army Inst Res, Div Psychiat & Neurosci, Dept Appl Neurobiol, Silver Spring, MD 20910 USA. [Wang, Kevin K.] Banyan Biomarkers Inc, Ctr Innovat Res, Diagnost Res & Dev Dept, Alachua, FL 32615 USA. [Wang, Kevin K.] Univ Florida, McKnight Brain Inst, Dept Psychiat, Ctr Neuroprote & Biomarkers Res, Gainesville, FL 32611 USA. [Hayes, Ronald L.] Banyan Biomarkers Inc, Ctr Innovat Res, Dept Clin Programs, Alachua, FL 32615 USA. RP Mondello, S (reprint author), Univ Florida, Dept Anesthesiol, 1600 SW Archer Rd, Gainesville, FL 32610 USA. EM stm_mondello@hotmail.com RI Mondello, Stefania/A-1813-2012; Czeiter, Endre/B-1404-2009; OI Mondello, Stefania/0000-0002-8587-3614; Wang, Kevin/0000-0002-9343-6473 FU Department of Defence [DAMD17-03-1-0772, DAMD17-03-1-0066]; NIH [R01 NS049175-01, R01-NS052831-01, R01 NS051431-01]; University of Florida [N00014-06-1-1029]; Banyan Biomarkers, Inc. FX We want to thank Professor Barzo, PI in Szeged, Dr. Paul Muizelaar, PI in UC Davis, and Dr. Richard Dutton, PI in Maryland Shock Trauma Center, for referring patients and for help collecting samples; We also acknowledge Dr. Komaromy as an independent CT reviewer; We are very grateful to medical and nursing staff of the neurointensive care unit for their valuable cooperation. This study was primarily sponsored by Department of Defence Award numbers DAMD17-03-1-0772 and DAMD17-03-1-0066; but we also acknowledge additional fund support from NIH (R01 NS049175-01, R01-NS052831-01, and R01 NS051431-01) and Navy grant number N00014-06-1-1029 (University of Florida).; Drs. Mondello, Papa, Buki, Bullock and Czeiter are consultants of and received consulting fees from Banyan Biomarkers, Inc.; Drs. Wang and Hayes own stock, receive royalties and salaries from, and are officers of Banyan Biomarkers Inc., and as such may benefit financially as a result of the outcomes of this research or work reported in this publication. Banyan Biomarkers, Inc. filled patent applications based upon the disclosure of this publication. Dr. Tortella reports no disclosures. NR 33 TC 74 Z9 77 U1 0 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1466-609X J9 CRIT CARE JI Crit. Care PY 2011 VL 15 IS 3 AR R156 DI 10.1186/cc10286 PG 10 WC Critical Care Medicine SC General & Internal Medicine GA 832JB UT WOS:000295799700038 PM 21702960 ER PT J AU Clausen, JL Bostick, B Korte, N AF Clausen, J. L. Bostick, B. Korte, N. TI Migration of Lead in Surface Water, Pore Water, and Groundwater With a Focus on Firing Ranges SO CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY LA English DT Review DE groundwater; lead; migration; shooting ranges ID METAL SORBED BIRNESSITE; BOND-VALENCE DETERMINATION; ABSORPTION FINE-STRUCTURE; PB(II) SORPTION PRODUCTS; DISSOLVED ORGANIC-MATTER; UNSATURATED POROUS-MEDIA; GOETHITE ALPHA-FEOOH; SHOOTING-RANGE; TRACE-METALS; HEAVY-METALS AB Lead has been widely introduced into the environment for centuries and lead toxicity has been well known for decades. Despite hundreds of articles describing lead's interaction with the environment, questions continue to be raised regarding the extent to which the element may migrate through soil and the vadose zone and contaminate groundwater. The authors examined lead geochemistry and field data and conclude that lead may migrate short distances in surface and pore water but that reports of lead in groundwater are related to vanishingly low natural concentrations, direct introduction of lead, or errors during sample handling or analysis. C1 [Clausen, J. L.] USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. [Bostick, B.] Columbia Univ, Lamont Doherty Earth Observ, Palisades, NY USA. [Korte, N.] Nic Korte Consulting, Grand Junction, CO USA. RP Clausen, JL (reprint author), USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA. EM Jay.L.Clausen@us.army.mil NR 236 TC 6 Z9 6 U1 1 U2 35 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1064-3389 EI 1547-6537 J9 CRIT REV ENV SCI TEC JI Crit. Rev. Environ. Sci. Technol. PY 2011 VL 41 IS 15 BP 1397 EP 1448 AR PII 938803600 DI 10.1080/10643381003608292 PG 52 WC Environmental Sciences SC Environmental Sciences & Ecology GA 779UA UT WOS:000291806500002 ER PT B AU Inglis, TJJ Eitzen, EM Robertson, AG AF Inglis, T. J. J. Eitzen, E. M. Robertson, A. G. BE Gall, J PayneJames, J TI Forensic investigation of biological weapon use SO CURRENT PRACTICE IN FORENSIC MEDICINE LA English DT Article; Book Chapter ID BIOTERRORISM-RELATED ANTHRAX; BACILLUS-ANTHRACIS; MICROBIAL FORENSICS; UNITED-STATES; SVERDLOVSK; OUTBREAK; DEATH C1 [Inglis, T. J. J.] PathWest Lab, Perth, WA, Australia. [Inglis, T. J. J.] Univ Western Australia, Nedlands, WA 6009, Australia. [Inglis, T. J. J.] Curtin Univ, Sch Biomed Sci, Perth, WA 6845, Australia. [Eitzen, E. M.] Martin Blanck & Associates, Biodef & Publ Hlth Grp, Falls Church, VA USA. [Eitzen, E. M.] US Army Med Corps, Washington, DC USA. [Eitzen, E. M.] USAMRIID, Ft Detrick, MD USA. [Eitzen, E. M.] US Dept HHS, Off Res & Dev, Off Publ Hlth Emergency Preparedness, Washington, DC USA. [Eitzen, E. M.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Robertson, A. G.] Western Australian WA Dept Hlth, Publ Hlth Div, Nedlands, WA, Australia. [Robertson, A. G.] Royal Australian Navy, Canberra, ACT, Australia. [Robertson, A. G.] WA Hlth, Disaster Preparedness & Management, Seattle, WA USA. [Robertson, A. G.] WA Hlth Team Indonesia, Perth, WA, Australia. RP Inglis, TJJ (reprint author), PathWest Lab, Perth, WA, Australia. NR 40 TC 2 Z9 2 U1 0 U2 0 PU WILEY-BLACKWELL PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER, WEST SUSSEX PO19 8SQ, ENGLAND BN 978-0-470-97316-5; 978-0-470-74487-1 PY 2011 BP 17 EP 42 D2 10.1002/9780470973158 PG 26 WC Medicine, Legal SC Legal Medicine GA BA5WG UT WOS:000337041400004 ER PT J AU Reese, D Henning, JS Rockers, K Ladd, D Gilson, R AF Reese, Drew Henning, J. Scott Rockers, Kyle Ladd, Denise Gilson, Robert TI Cyclosporine for SJS/TEN: A Case Series and Review of the Literature SO CUTIS LA English DT Article ID TOXIC EPIDERMAL NECROLYSIS; STEVENS-JOHNSON-SYNDROME; EXPRESSION; APOPTOSIS; RECEPTORS; CELLS AB Clear guidelines for the treatment of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are lacking due to its infrequency and the absence of large controlled studies. Systemic corticosteroids and intravenous immunoglobulin (IVIG) have received considerable attention, though reports of the use of these agents have demonstrated mixed success rates in improving morbidity and mortality from SJS/TEN. We present a case series of 4 patients with SJS/TEN who rapidly responded to treatment with cyclosporin A (CsA). We discuss the proposed mechanism of action and the rationale for the use of cyclosporin based on the currently understood pathophysiologic mechanism of TEN. Cutis. 2011;87:24-29. C1 [Reese, Drew; Henning, J. Scott; Rockers, Kyle; Ladd, Denise; Gilson, Robert] Wilford Hall USAF Med Ctr, Dept Dermatol, Lackland AFB, TX USA. RP Reese, D (reprint author), Reynolds Army Community Hosp, Dept Dermatol, 4301 Wilson St, Ft Sill, OK 73503 USA. EM drew.reese@amedd.army.mil NR 15 TC 17 Z9 17 U1 1 U2 3 PU QUADRANT HEALTHCOM INC PI PARSIPPANY PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA SN 0011-4162 J9 CUTIS JI Cutis PD JAN PY 2011 VL 87 IS 1 BP 24 EP 29 PG 6 WC Dermatology SC Dermatology GA 713EH UT WOS:000286717300006 PM 21323097 ER PT J AU Walsh, DS Portaels, F Meyers, WM AF Walsh, Douglas S. Portaels, Francoise Meyers, Wayne M. TI Buruli Ulcer: Advances in Understanding Mycobacterium ulcerans Infection SO DERMATOLOGIC CLINICS LA English DT Article DE Buruli ulcer; Mycobacterium ulcerans; Emerging disease; Skin disease; Mycolactone ID BOVIS BCG VACCINATION; LABORATORY DIAGNOSIS; ANTIBIOTIC-TREATMENT; CLINICAL-EFFICACY; IMMUNE-RESPONSE; DISEASE; BENIN; STREPTOMYCIN; COMBINATION; RIFAMPIN AB Buruli ulcer (BU), caused by the environmental organism Mycobacterium ulcerans and characterized by necrotizing skin and bone lesions, poses important public health issues as the third most common mycobacterial infection in humans. Pathogenesis of M ulcerans is mediated by mycolactone, a necrotizing immunosuppressive toxin. First-line therapy for BU is rifampin plus streptomycin, sometimes with surgery. New insights into the pathogenesis of BU should improve control strategies. C1 [Walsh, Douglas S.] US Army Med Component, Dept Immunol & Med, Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Portaels, Francoise] Inst Trop Med, Mycobacteriol Unit, Dept Microbiol, B-2000 Antwerp, Belgium. [Meyers, Wayne M.] Armed Forces Inst Pathol, Dept Environm & Infect Dis Sci, Washington, DC 20306 USA. RP Walsh, DS (reprint author), US Army Med Component, Dept Immunol & Med, Armed Forces Res Inst Med Sci, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM douglas.walsh@afrims.org NR 52 TC 34 Z9 34 U1 0 U2 7 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0733-8635 J9 DERMATOL CLIN JI Dermatol. Clin. PD JAN PY 2011 VL 29 IS 1 BP 1 EP + DI 10.1016/j.det.2010.09.006 PG 9 WC Dermatology SC Dermatology GA 701VG UT WOS:000285851300002 PM 21095521 ER PT S AU Hopkins, DA Gazonas, GA AF Hopkins, David A. Gazonas, George A. BE Kriven, WM Gyekenyesi, AL Wang, J TI COMPUTATIONAL STUDY OF WAVE PROPAGATION IN SECOND-ORDER NONLINEAR PIEZOELECTRIC MEDIA SO DEVELOPMENTS IN STRATEGIC MATERIALS AND COMPUTATIONAL DESIGN II SE Ceramic Engineering and Science Proceedings LA English DT Proceedings Paper CT 35th International Conference and Exposition on Advanced Ceramics and Composites CY JAN 23-28, 2011 CL Daytona Beach, FL SP Amer Ceram Soc, Engn Ceram Div, Amer Ceram Soc, Nucl & Environm Technol Div, Amer Ceram Soc ID EQUATIONS; CRYSTALS AB In this paper, we present computational results for the response of piezoelectric materials with 6mm symmetry when subjected to shock loads. The governing equations are based on a second-order theory of piezoelectricity for the 6mm crystal class formulated in a Lagrangian reference configuration. These equations represent the fully coupled nonlinear rnultiphysics response. Numerical solutions of these equations are first verified using analytical solutions for wave propagation in linear piezoelectric media. The effects of the nonlinear coupling introduced by higher order elastic, dielectric and piezoelectric coupling coefficients are then examined. The wave speed is shown to be lower than the bar velocity predicted by linear piezoelectricity for large strains. C1 [Hopkins, David A.; Gazonas, George A.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Hopkins, DA (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. NR 31 TC 0 Z9 0 U1 0 U2 0 PU AMER CERAMIC SOC PI WESTERVILLE PA 735 CERAMIC PLACE, WESTERVILLE, OH 43081-8720 USA SN 0196-6219 BN 978-1-118-09539-3; 978-1-118-17237-7 J9 CERAM ENG SCI PROC PY 2011 VL 32 BP 165 EP 174 PG 10 WC Materials Science, Ceramics; Materials Science, Composites SC Materials Science GA BG7ZT UT WOS:000392129100016 ER PT S AU Ibrahim, SM Aitichou, M Hardick, J Blow, J O'Guinn, ML Schmaljohn, C AF Ibrahim, Sofi M. Aitichou, Mohamed Hardick, Justin Blow, Jamie O'Guinn, Monica L. Schmaljohn, Connie BE Stephenson, JR Warnes, A TI Detection of Crimean-Congo Hemorrhagic Fever, Hanta, and Sandfly Fever Viruses by Real-Time RT-PCR SO DIAGNOSTIC VIROLOGY PROTOCOLS, SECOND EDITION SE Methods in Molecular Biology LA English DT Article; Book Chapter DE CCHF virus; Sandfly fever virus; Andes virus; Hantaan virus; Fluorescence-based real-time assay ID REVERSE-TRANSCRIPTASE-PCR; PULMONARY SYNDROME; RENAL-SYNDROME; QUANTIFICATION; IDENTIFICATION; DOBRAVA; ASSAY AB The development of sensitive and specific nucleic acid diagnostic assays for viral pathogens is essential for proper medical intervention. This chapter describes four fluorescence-based PCR assays to detect the Crimean Congo Hemorrhagic Fever (CCHFV), Andes (ANDV), Hantaan (HANV), and Sandfly Fever Sicilian (SFSV) Viruses. These assays are based on species-specific hydrolysis probes targeting the nucleocapsid protein gene for CCHFV and SFSV and the glycoprotein gene for ANDV and HANV. All four assays were optimized for LightCycler 2.0 (Roche Diagnostics, Indianapolis, IN) or Ruggedized Advanced Pathogen Identification Device (R.A.P.I.D.; Idaho Technology Inc., Salt Lake City, UT). The assays were evaluated using the protocols described in the Subheading 3. The limits of detection were approximately 5, 2, 2, and 5 plaque-forming units (PFUs) for CCHFV, ANDV, HTNV, and SFSV assays, respectively. The sensitivity and specificity of the assays were evaluated with test panels that consisted of 20-60 known positive and 30-135 known negative samples, representing 7-34 genetically diverse bacterial and viral species. The CCHFV assay detected 59 out of the 60 positive samples and no false positives, resulting in 98.3% sensitivity at LOD of 5 PFU and 100% specificity. The ANDV and HTNV assays correctly identified all the positive samples with no false positive reactions; therefore, the sensitivity and specificity of these assays were determined to be 100% at LOD of 2 PFU. The SFSV assay missed three positive samples and cross-reacted with one of 48 negative samples, resulting in 95% sensitivity at LOD of 5 PFU and 98% specificity. C1 [Ibrahim, Sofi M.; Aitichou, Mohamed; Hardick, Justin; O'Guinn, Monica L.; Schmaljohn, Connie] USA, Med Res Inst Infect Dis, Frederick, MD USA. [Blow, Jamie] Armed Forces Pest Management Board, Silver Spring, MD USA. RP Ibrahim, SM (reprint author), USA, Med Res Inst Infect Dis, Frederick, MD USA. NR 21 TC 7 Z9 8 U1 1 U2 5 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA SN 1064-3745 BN 978-1-60761-816-4 J9 METHODS MOL BIOL JI Methods Mol. Biol. PY 2011 VL 665 BP 357 EP 368 DI 10.1007/978-1-60761-817-1_19 D2 10.1007/978-1-60761-817-1 PG 12 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Virology SC Biochemistry & Molecular Biology; Virology GA BSU95 UT WOS:000285850300019 PM 21116810 ER PT S AU Grimme, JM Spies, M AF Grimme, Jill M. Spies, Maria BE Tsubouchi, H TI FRET-Based Assays to Monitor DNA Binding and Annealing by Rad52 Recombination Mediator Protein SO DNA RECOMBINATION: METHODS AND PROTOCOLS SE Methods in Molecular Biology LA English DT Article; Book Chapter DE Annealing protein; fluorescence; Foster resonance energy transfer (FRET); homologous recombination; Rad52; recombination mediator; RPA ID SINGLE-STRANDED-DNA; HOMOLOGOUS RECOMBINATION; CONFORMATIONAL-CHANGE; BRANCH MIGRATION; BREAK REPAIR; YEAST; COMPLEXES; FORM; IDENTIFICATION; MECHANISM AB During homologous recombination and homology-directed repair of broken chromosomes, proteins that mediate and oppose recombination form dynamic complexes on damaged DNA. Quantitative analysis of these nucleoprotein assemblies requires a robust signal, which reports on the association of a recombination mediator with its substrate and on the state of substrate DNA within the complex. Eukaryotic Rad52 protein mediates recombination, repair, and restart of collapsed replication forks by facilitating replacement of ssDNA binding protein replication protein A (RPA) with Rad51 recombinase and by mediating annealing of two complementary DNA strands protected by RPA. The characteristic binding mode whereby ssDNA is wrapped around the Rad52 ring allowed us to develop robust and sensitive FRET-based assays for monitoring Rad52 interactions with protein-free DNA and ssDNA RPA complexes. By reporting on the configuration of ssDNA dually labeled with Cy3 and Cy5 fluorescent dyes, solution-based FRET is used to analyze Rad52 RPA DNA interactions under equilibrium binding conditions. Finally, FRET between Cy3 and Cy5 dyes incorporated into two homologous ssDNA molecules can be used to analyze interplay between Rad52-mediated DNA strand annealing and duplex DNA destabilization by RPA. C1 [Grimme, Jill M.] USA, Construct Engn Res Lab, Engineer Res Dev Ctr, Champaign, IL 61824 USA. [Spies, Maria] Univ Illinois, Dept Biochem, Howard Hughes Med Inst, Urbana, IL 61801 USA. RP Grimme, JM (reprint author), USA, Construct Engn Res Lab, Engineer Res Dev Ctr, Champaign, IL 61824 USA. OI Spies, Maria/0000-0002-7375-8037 FU Howard Hughes Medical Institute NR 41 TC 5 Z9 5 U1 0 U2 4 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA SN 1064-3745 BN 978-1-61779-128-4 J9 METHODS MOL BIOL JI Methods Mol. Biol. PY 2011 VL 745 BP 463 EP 483 DI 10.1007/978-1-61779-129-1_27 D2 10.1007/978-1-61779-129-1 PG 21 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA BVR27 UT WOS:000292530400027 PM 21660711 ER PT J AU von Cresce, A Xu, K AF von Cresce, Arthur Xu, Kang TI Preferential Solvation of Li+ Directs Formation of Interphase on Graphitic Anode SO ELECTROCHEMICAL AND SOLID STATE LETTERS LA English DT Article ID ORGANIC ELECTROLYTE-SOLUTIONS; IONIZATION-MASS-SPECTROSCOPY; ETHYLENE CARBONATE; GRAPHITE/ELECTROLYTE INTERFACE; NONAQUEOUS ELECTROLYTES; LITHIUM IONS; BATTERIES; SHEATH AB It remains controversial over whether preferential solvation occurs when lithium salts are dissolved in typical binary electrolytes. While the role of Li+-solvation sheath in directing interphasial chemistry on graphitic anode surface has become recognized, it is imperative to understand the quantitative structure of such sheaths. Employing a soft ionization mass spectrum technique, statistic distribution of cyclic and acyclic carbonate molecules within the Li+-solvation sheath was successfully established. The quantitative mapping of sheath structure against bulk electrolyte composition reveals unambiguous preference of cyclic over acyclic carbonate molecules by Li+. (C) 2011 The Electrochemical Society. [DOI: 10.1149/1.3615828] All rights reserved. C1 [von Cresce, Arthur; Xu, Kang] USA, Electrochem Branch, Power & Energy Div, Sensor & Elect Devices Directorate,Res Lab, Adelphi, MD 20783 USA. RP von Cresce, A (reprint author), USA, Electrochem Branch, Power & Energy Div, Sensor & Elect Devices Directorate,Res Lab, Adelphi, MD 20783 USA. EM conrad.k.xu.civ@mail.mil RI Cresce, Arthur/K-3958-2013 OI Cresce, Arthur/0000-0002-3894-6083 FU Department of Energy (DOE-ABRT) FX This project was partially funded by Advanced Battery Research for Transportation Program of Department of Energy (DOE-ABRT). The authors also want to thank Dr. Yue Li of University of Maryland, College Park, for ESI-MS services, and Dr. Oleg Borodin (ARL) for discussions. NR 21 TC 24 Z9 24 U1 2 U2 27 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 SOUTH MAIN STREET, PENNINGTON, NJ 08534 USA SN 1099-0062 J9 ELECTROCHEM SOLID ST JI Electrochem. Solid State Lett. PY 2011 VL 14 IS 10 BP A154 EP A156 DI 10.1149/1.3615828 PG 3 WC Electrochemistry; Materials Science, Multidisciplinary SC Electrochemistry; Materials Science GA 824OM UT WOS:000295211600005 ER PT J AU Grew, KN Ren, XM Chu, D AF Grew, Kyle N. Ren, Xiaoming Chu, Deryn TI Effects of Temperature and Carbon Dioxide on Anion Exchange Membrane Conductivity SO ELECTROCHEMICAL AND SOLID STATE LETTERS LA English DT Article ID ALKALINE FUEL-CELL; POLYMER ELECTROLYTE; PROTON TRANSPORT; PERFORMANCE; THERMODYNAMICS; EQUILIBRIUM; HYDROXIDE; NAFION AB In an anion exchange membrane (AEM), the dissolution of carbon dioxide (CO(2)) in water results in the conversion of hydroxide to the less mobile (bi)carbonates. Theory is developed to explain the temperature and CO(2) content dependencies of the measured AEM ionic conductivity in terms of distribution and motilities of the mobile ions within the membrane. Such understanding is valuable for developing AEM technologies, such as in (i) deriving properties not easily measurable including pH values, ion concentrations and transport numbers, and (ii) identifying material properties and characterization methodologies that impact the membrane's function and stability in fuel cell applications. (C) 2011 The Electrochemical Society. [DOI:10.1149/2.011112esl] All rights reserved. C1 [Grew, Kyle N.; Ren, Xiaoming; Chu, Deryn] USA, Res Lab, Adelphi, MD 20783 USA. RP Grew, KN (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM kyle.n.grew.ctr@mail.mil RI Grew, Kyle/K-3982-2013; ren, xiaoming/F-3953-2011 OI Grew, Kyle/0000-0002-1645-3835; FU U.S. Department of the Army; U.S. Army Materiel Command; U.S. Army Research Laboratory FX Financial support from the U.S. Department of the Army and U.S. Army Materiel Command are gratefully acknowledged. Research was supported, in part, by a contractual appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities. NR 23 TC 15 Z9 15 U1 2 U2 15 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 SOUTH MAIN STREET, PENNINGTON, NJ 08534 USA SN 1099-0062 J9 ELECTROCHEM SOLID ST JI Electrochem. Solid State Lett. PY 2011 VL 14 IS 12 BP B127 EP B131 DI 10.1149/2.011112esl PG 5 WC Electrochemistry; Materials Science, Multidisciplinary SC Electrochemistry; Materials Science GA 843GU UT WOS:000296661100007 ER PT J AU Zhang, SS Foster, D Read, J AF Zhang, Sheng S. Foster, Donald Read, Jeffrey TI The effect of quaternary ammonium on discharge characteristic of a non-aqueous electrolyte Li/O-2 battery SO ELECTROCHIMICA ACTA LA English DT Article DE Li/air battery; Li/O-2 battery; Oxygen reduction; Quaternary ammonium; Non-aqueous electrolyte ID LITHIUM/OXYGEN BATTERY; LITHIUM/AIR BATTERIES; ORGANIC ELECTROLYTE; PERFORMANCE AB The effect of quaternary ammonium on discharge characteristic of Li/O-2 cells was studied by using Super-P carbon as air cathode, a 0.2 mol kg(-1) LiSO3CF3 1:3 (wt.) PC/DME solution as baseline electrolyte, and tetrabutylammonium triflate (NBu4SO3CF3) as an electrolyte additive or a co-salt. Results show that Li/O-2 cells can run normally in an electrolyte with NBu4SO3CF3 as the sole conductive salt. However, such cells suffer lower voltage and capacity as compared with those using the lithium ionic baseline electrolyte. This is due to the larger molar volume of quaternary ammonium cation, which results in less deposition of oxygen reduction products on the surface of carbon. When used as an electrolyte additive or a co-salt, the ammonium is shown to increase capacity of Li/O-2 cells. The plot of differential capacity versus cell voltage shows that the Li/O-2 cell with ammonium added has broad and scatted differential capacity peaks between the voltages of two reactions of "2Li + O-2 -> Li2O2" and "2Li + Li2O2 -> 2Li(2)O". This phenomenon can be attributed to the phase transfer catalysis (PTC) property of quaternary ammonium on the second reaction. Due to inverse effects of the cation geometric volume and the PTC property of ammonium ions on the discharge capacity, there is an optimum range for the concentration of ammonium. It is shown that the addition of NBu4SO3CF3 increases discharge capacity of Li/O-2 cell only when its concentration is in a range from 5 mol% to 50 mol% vs. the total of Li/ammonium mixed salt, and that the optimum concentration is about 5 mol%. In this work we show that the addition of 5 mol% NBu4SO3CF3 into the baseline electrolyte can increase discharge capacity of a Li/O-2 cell from 732 mAh g(-1) to 1068 mAh g(-1) (in reference to the weight of Super-P carbon) when the cell is discharged at 0.2 mA cm(-2). Published by Elsevier Ltd. C1 [Zhang, Sheng S.; Foster, Donald; Read, Jeffrey] USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), USA, Res Lab, RDRL SED C, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM szhang@arl.army.mil RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 16 TC 18 Z9 18 U1 6 U2 53 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0013-4686 EI 1873-3859 J9 ELECTROCHIM ACTA JI Electrochim. Acta PD JAN 1 PY 2011 VL 56 IS 3 BP 1283 EP 1287 DI 10.1016/j.electacta.2010.10.052 PG 5 WC Electrochemistry SC Electrochemistry GA 746EL UT WOS:000289225400038 ER PT J AU Cao, XY Ro, KS Chappell, M Li, YA Mao, JD AF Cao, Xiaoyan Ro, Kyoung S. Chappell, Mark Li, Yuan Mao, Jingdong TI Chemical Structures of Swine-Manure Chars Produced under Different Carbonization Conditions Investigated by Advanced Solid-State C-13 Nuclear Magnetic Resonance (NMR) Spectroscopy SO ENERGY & FUELS LA English DT Article ID SUPERCRITICAL WATER GASIFICATION; NATURAL ORGANIC-MATTER; BED FAST PYROLYSIS; BIO-OIL; HYDROTHERMAL CARBONIZATION; THERMOCHEMICAL CONVERSION; BIOMASS GASIFICATION; RICE HUSK; BIOCHAR; CARBON AB Two types of swine-manure chars, hydrothermally produced hydrochar and slow-pyrolysis pyrochar, and their raw swine-manure solid were characterized using advanced solid-state C-13 nuclear magnetic resonance (NMR) spectroscopy. In comparison to raw swine-manure solid, both hydrochars and pyrochar displayed significantly different structural features, with lower alkyl carbons, NCH, OCH3, O-alkyl, and COO/N-C=O groups but higher aromatic/olefinic and aromatic C-O groups. The chemical structures of four hydrochars varied with different processing conditions. In comparison to the hydrochar with only water wash (HTC-swine W), washing hydrochar with acetone (HTC-swine A) removed the soluble intermediates deposited on the hydrochar, as shown by the decrease of O-alkyl (primarily carbohydrates), corresponding increase of aromatic/olefinic carbons and complete removal of OCH3 groups. With citric acid prewash and acetone wash (HTC-AW-swine A), aromatic C-O and aromatics/olefinics were increased and alkyls were decreased, with O-alkyls totally removed in comparison to just acetone wash (HTC-swine A). Citric acid catalysis and acetone wash (HTC-AC-swine A) increased aromatic C-O and non-protonated aromatics/olefinics, decreased alkyls further, and reduced protonated aromatics/olefinics compared to citric acid prewash and acetone wash (HTC-AW-swine A). The ratios of non-protonated to protonated aromatic/olefinic carbons for HTC-swine W, HTC-swine A, and HTC-AW-swine A hydrochars were quite similar but enhanced for HTC-AC-swine A hydrochar. Obviously, citric acid catalysis and acetone wash (HTC-AC-swine A) provided deeper carbonization than other hydrothermal processes. Hydrothermal carbonization (HTC) processes were associated with the hydrolysis and subsequent decomposition of major biopolymer components in swine manure. The increase of aromaticity during HTC was likely due to condensation polymerization of the intermediates from the degradation of carbohydrates. Pyrochar produced from slow pyrolysis was structurally different from HTC hydrochars. The dominant component of pyrochar was aromatics, whereas that of hydrochars was alkyl moieties. The aromatic cluster size of pyrochar was larger than those of hydrochars. Slow pyrolysis at 620 degrees C provided deeper carbonization than HTC processes. C1 [Cao, Xiaoyan; Li, Yuan; Mao, Jingdong] Old Dominion Univ, Dept Chem & Biochem, Norfolk, VA 23529 USA. [Ro, Kyoung S.] ARS, Coastal Plains Soil Water & Plant Res Ctr, USDA, Florence, SC 29501 USA. [Chappell, Mark] USA, Corps Engineers, Environm Lab, Vicksburg, MS 39180 USA. RP Mao, JD (reprint author), Old Dominion Univ, Dept Chem & Biochem, 4541 Hampton Blvd, Norfolk, VA 23529 USA. EM jmao@odu.edu RI Cao, Xiaoyan/E-3492-2012 OI Cao, Xiaoyan/0000-0001-7571-6482 FU National Science Foundation [EAR-0843996, CBET-0853950]; Petroleum Research Fund [46373-G2]; USDA-ARS [NFCA 6657-13630-004-01N] FX We thank the National Science Foundation (EAR-0843996 and CBET-0853950) and the Donors of the Petroleum Research Fund, administered by the American Chemical Society (Grant 46373-G2), for the support of this research. Collaboration with the USDA-ARS was conducted according to the agreement NFCA 6657-13630-004-01N. NR 78 TC 71 Z9 76 U1 3 U2 111 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0887-0624 EI 1520-5029 J9 ENERG FUEL JI Energy Fuels PD JAN PY 2011 VL 25 BP 388 EP 397 DI 10.1021/ef101342v PG 10 WC Energy & Fuels; Engineering, Chemical SC Energy & Fuels; Engineering GA 721ID UT WOS:000287345900048 ER PT S AU Barnes, MJ Chen, JYC Jentsch, F Redden, ES AF Barnes, Michael J. Chen, Jessie Y. C. Jentsch, Florian Redden, Elizabeth S. BE Harris, D TI Designing Effective Soldier-Robot Teams in Complex Environments: Training, Interfaces, and Individual Differences SO ENGINEERING PSYCHOLOGY AND COGNITIVE ERGONOMICS SE Lecture Notes in Artificial Intelligence LA English DT Proceedings Paper CT 9th International Conference on Engineering Psychology and Cognitive Ergonomics (EPCE) Held as Part of 14th International Conference on Human-Computer Interaction (HCI) CY JUL 09-14, 2011 CL Orlando, FL DE HRI design; military; human factors ID SIMULATED MULTITASKING ENVIRONMENT; CONCURRENT PERFORMANCE; TASKS; AUTOMATION; MILITARY AB Extensive US Army programs are being pursued to increase the effectiveness of unmanned vehicles for diverse missions during future combat. The following paper identified 23 human-robot interaction (HRI) guidelines related to interface design, procedural issues, individual differences and training implications based on three HRI research programs. The programs range from simulation experiments that investigated robot control in a multitasking environment from a mounted combat vehicle, to reconnaissance missions in a miniature Iraqi city that focused on Soldier-robot teaming relationships, to field studies at Ft. Benning that examined interface design issues for Soldiers supervising or controlling small robots. C1 [Barnes, Michael J.; Chen, Jessie Y. C.; Redden, Elizabeth S.] USA, Res Lab Human Res & Engn Directorate, Bldg 459, Aberdeen Proving Ground, MD 21005 USA. [Jentsch, Florian] Univ Cent Florida, Dept Psychol, Orlando, FL 32816 USA. RP Barnes, MJ (reprint author), USA, Res Lab Human Res & Engn Directorate, Bldg 459, Aberdeen Proving Ground, MD 21005 USA. EM michael.j.barnes@us.army.mil; jessie.chen@us.army.mil; fjentsch@mail.ucf.edu; elizabeth.redden@us.army.mil NR 23 TC 4 Z9 4 U1 1 U2 3 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0302-9743 BN 978-3-642-21740-1; 978-3-642-21741-8 J9 LECT NOTES ARTIF INT PY 2011 VL 6781 BP 484 EP 493 PG 10 WC Computer Science, Artificial Intelligence SC Computer Science GA BDB82 UT WOS:000312502700051 ER PT S AU Flores, JH Martin, GA Durlach, PJ AF Flores, Jaime H. Martin, Glenn A. Durlach, Paula J. BE Harris, D TI A Testbed for Exploring Human-Robot Interaction with Unmanned Aerial and Ground Vehicles SO ENGINEERING PSYCHOLOGY AND COGNITIVE ERGONOMICS SE Lecture Notes in Artificial Intelligence LA English DT Proceedings Paper CT 9th International Conference on Engineering Psychology and Cognitive Ergonomics (EPCE) Held as Part of 14th International Conference on Human-Computer Interaction (HCI) CY JUL 09-14, 2011 CL Orlando, FL DE Interface Usability; Unmanned Vehicles; Team Collaboration AB Over the last twenty years, the emerging roles of unmanned aerial/ground vehicles in the U.S. military presented a number of different research opportunities in usability and training, ranging from robotic control interfaces to human-robot team collaboration. In this paper we present a testbed that we developed as a flexible software platform to explore a variety of training and coordination issues with UXVs for military application. C1 [Flores, Jaime H.; Martin, Glenn A.] Univ Cent Florida, Inst Simulat & Training, 3100 Technol Pkwy, Orlando, FL 32826 USA. [Durlach, Paula J.] US Army, Res Inst Behav & Social Sci, Orlando, FL USA. RP Flores, JH (reprint author), Univ Cent Florida, Inst Simulat & Training, 3100 Technol Pkwy, Orlando, FL 32826 USA. EM jflores@ist.ucf.edu; martin@ist.ucf.edu; Paula.Durlach@us.army.mil NR 6 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0302-9743 BN 978-3-642-21740-1; 978-3-642-21741-8 J9 LECT NOTES ARTIF INT PY 2011 VL 6781 BP 514 EP 521 PG 8 WC Computer Science, Artificial Intelligence SC Computer Science GA BDB82 UT WOS:000312502700054 ER PT J AU Niu, N Jin, MZ Cheng, JRC AF Niu, Nan Jin, Mingzhou Cheng, Jing-Ru C. TI A case study of exploiting enterprise resource planning requirements SO ENTERPRISE INFORMATION SYSTEMS LA English DT Article DE enterprise resource planning; requirements engineering; Oracle; application implementation method; exploratory case study ID ERP SYSTEMS; INFORMATION-SYSTEMS; IMPLEMENTATION; SUCCESS; FUNCTIONALITY; INNOVATION; FRAMEWORK; PROJECTS; ADOPTION; PACKAGE AB The requirements engineering (RE) processes have become a key to conceptualising corporate-wide integrated solutions based on packaged enterprise resource planning (ERP) software. The RE literature has mainly focused on procuring the most suitable ERP package. Little is known about how an organisation exploits the chosen ERP RE model to frame the business application development. This article reports an exploratory case study of a key tenet of ERP RE adoption, namely that aligning business applications to the packaged RE model leads to integral practices and economic development. The case study analysed a series interrelated pilot projects developed for a business division of a large IT manufacturing and service company, using Oracle's appl1ication implementation method (AIM). The study indicated that AIM RE improved team collaboration and project management experience, but needed to make hidden assumptions explicit to support data visibility and integrity. Our study can direct researchers towards rigorous empirical evaluations of ERP RE adoption, collect experiences and lessons learned for practitioners, and help generate more effective and mature processes when exploiting ERP RE methods. C1 [Niu, Nan] Mississippi State Univ, Dept Comp Sci & Engn, Mississippi State, MS 39762 USA. [Jin, Mingzhou] Mississippi State Univ, Dept Ind & Syst Engn, Mississippi State, MS 39762 USA. [Cheng, Jing-Ru C.] USA, Informat Technol Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Niu, N (reprint author), Mississippi State Univ, Dept Comp Sci & Engn, Mississippi State, MS 39762 USA. EM niu@cse.msstate.edu NR 54 TC 27 Z9 27 U1 0 U2 29 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 1751-7575 EI 1751-7583 J9 ENTERP INF SYST-UK JI Enterp. Inf. Syst. PY 2011 VL 5 IS 2 BP 183 EP 206 AR PII 932737554 DI 10.1080/17517575.2010.519052 PG 24 WC Computer Science, Information Systems SC Computer Science GA 750TC UT WOS:000289569900002 ER PT S AU Chappell, MA AF Chappell, Mark A. BE Chappell, MA Price, CL George, RD TI Solid-Phase Considerations for the Environmental Fate of TNT and RDX in Soil SO ENVIRONMENTAL CHEMISTRY OF EXPLOSIVES AND PROPELLANT COMPOUNDS IN SOILS AND MARINE SYSTEMS: DISTRIBUTED SOURCE CHARACTERIZATION AND REMEDIAL TECHNOLOGIES SE ACS Symposium Series LA English DT Proceedings Paper CT Symposium on Environmental Distribution, Degradation, and Mobility of Explosive and Propellant Compounds CY MAR 22-25, 2009 CL Salt Lake City, UT SP ACS, Div Environm Chem ID IONIC ORGANIC-COMPOUNDS; CLAY-MINERALS; SUBSTITUTED NITROBENZENES; NITROAROMATIC COMPOUNDS; ADSORPTION MECHANISMS; CONTAMINATED SOIL; WATER SLURRIES; SMECTITE CLAYS; SORPTION; 2,4,6-TRINITROTOLUENE AB This chapter provides a basic review of the environmental fate of the two most common munition constituents used by the DoD, TNT and RDX. Here is reviewed the basic scientific literature of nitroaromatic and tirazine sorption, with specific data that is available for TNT and RDX. In general, the behavior of these munition constituents (MC) in soils and sediments is generally well described by the available information for nitroaromatic and triazine compounds, with notable differences attributed to the ready reduction of MC nitro groups to amine derivatives. In general, the environmental fate of TNT is much better described in the scientific literature, emphasizing a remaining need for more research elucidating the behavior of RDX in soil and sediments. Here, we summarize trends in reported partitioning coefficients describing sorption of MC with soil/sediment cation exchange capacity (CEC), extractable Fe, and exchangeable Ca. New concepts in terms of fugacity-based quantity-intensity theory are introduced for more detailed descriptions of sorption behavior. Also, we expand on classical considerations of soil biological degradation potentials to include agricultural concepts of soil tilth for predicting the long-term fate of MC in soil. This review focuses on the sorption processes of two important MCs in soils and sediments, 1,3,5-trinitrotoluene (TNT) and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX, Fig. 1). One of the more difficult aspects of understanding the environmental fate of these contaminants lies in their relatively weak interactions with soil. As noncharged organics with limited water solubility, these compounds do not interact with strongly charged soil surfaces like exchangeable cation species, but are limited to interactions with micro-scale hydrophobic or noncharged mineral domains, and the flexible, often surfactant-like humic polymers. The principles and challenges of understanding the sorption and transport of MC and nitrobenzene and triazine compounds in general are discussed here. C1 USA, ERDC, Environm Lab, Vicksburg, MS USA. RP Chappell, MA (reprint author), USA, ERDC, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS USA. EM mark.a.chappell@usace.army.mil NR 81 TC 3 Z9 3 U1 0 U2 10 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA SN 0097-6156 BN 978-0-8412-2632-6 J9 ACS SYM SER JI ACS Symp. Ser. PY 2011 VL 1069 BP 1 EP 25 PG 25 WC Chemistry, Multidisciplinary; Engineering, Environmental SC Chemistry; Engineering GA BDF54 UT WOS:000313022700001 ER PT S AU Walsh, ME Hewitt, AD Jenkins, TF Ramsey, CA Walsh, MR Bigl, SR Collins, CM Chappells, MA AF Walsh, Marianne E. Hewitt, Alan D. Jenkins, Thomas F. Ramsey, Charles A. Walsh, Michael R. Bigl, Susan R. Collins, Charles M. Chappells, Mark A. BE Chappell, MA Price, CL George, RD TI Assessing Sample Processing and Sampling Uncertainty for Energetic Residues on Military Training Ranges: Method 8330B SO ENVIRONMENTAL CHEMISTRY OF EXPLOSIVES AND PROPELLANT COMPOUNDS IN SOILS AND MARINE SYSTEMS: DISTRIBUTED SOURCE CHARACTERIZATION AND REMEDIAL TECHNOLOGIES SE ACS Symposium Series LA English DT Proceedings Paper CT Symposium on Environmental Distribution, Degradation, and Mobility of Explosive and Propellant Compounds CY MAR 22-25, 2009 CL Salt Lake City, UT SP ACS, Div Environm Chem ID IN-PLACE DETONATIONS; SUBSAMPLING VARIANCE; LIVE-FIRE AB The standard analytical method to determine explosives in soils (EPA SW-846 Method 8330) was developed in the late 1980s to support efforts to remediate Army ammunition plants and depots where wastewater from munitions production was released onto the soil. Subsequently, the characterization of energetic residues on military training ranges required the development of field sampling and laboratory processing methods suitable for the unique nature of the explosives and propellants dispersed by live-firing exercises. The revised method is based on research at more than 50 training ranges and addresses the uncertainty due to the heterogeneity in the physical form and the spatial distribution of these potentially hazardous constituents. The revised method (8330B) provides guidance for sampling and processing of soil samples. Proper sampling involves collecting an adequate number of evenly spaced increments from throughout a decision unit to reduce uncertainty due to distributional heterogeneity and enough mass to reduce uncertainty due to compositional heterogeneity. Soil samples may be several kilograms, and the entire sample must be processed to maintain representativeness. C1 [Walsh, Marianne E.; Walsh, Michael R.; Bigl, Susan R.; Collins, Charles M.] USA, ERDC CRREL, Hanover, NH 03755 USA. RP Walsh, ME (reprint author), USA, ERDC CRREL, 72 Lyme Rd, Hanover, NH 03755 USA. EM Marianne.E.Walsh@usace.army.mil NR 16 TC 1 Z9 1 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA SN 0097-6156 BN 978-0-8412-2632-6 J9 ACS SYM SER JI ACS Symp. Ser. PY 2011 VL 1069 BP 91 EP 106 PG 16 WC Chemistry, Multidisciplinary; Engineering, Environmental SC Chemistry; Engineering GA BDF54 UT WOS:000313022700005 ER PT S AU Clausen, JL AF Clausen, J. L. BE Chappell, MA Price, CL George, RD TI Energetic Residue Observations for Operational Ranges SO ENVIRONMENTAL CHEMISTRY OF EXPLOSIVES AND PROPELLANT COMPOUNDS IN SOILS AND MARINE SYSTEMS: DISTRIBUTED SOURCE CHARACTERIZATION AND REMEDIAL TECHNOLOGIES SE ACS Symposium Series LA English DT Proceedings Paper CT Symposium on Environmental Distribution, Degradation, and Mobility of Explosive and Propellant Compounds CY MAR 22-25, 2009 CL Salt Lake City, UT SP ACS, Div Environm Chem AB Over the past 20 years the US Army Corps of Engineers (USACE) Engineer Research and Development Center (ERDC) Cold Regions Research and Engineering Laboratory (CRREL), USACE ERDC Environmental Laboratory (EL), US Army Public Health Command, Defense Research Establishment Valcartier - Canada, and various contractors have been engaged in the assessment of operational military ranges in the US and Canada to understand the extent of energetic residues derived from training. Surface soil sampling conducted at over 30 military installations has been the primary means of assessing the ranges. In addition to surface soil sampling, other media types have been assessed to a lesser degree including subsurface soil, surface water (including snow), storm water runoff, vadose zone pore-water, and groundwater. The primary focus of previous assessments has been on Army ranges; however a number of Air Force and Navy ranges have been studied. Samples were collected at open burn/open detonatiom (OB/OD) areas, firing points, and impact areas. Ranges were further subdivided depending on the type of weapon system being trained with, such as artillery, mortar, rocket, bombs, grenade, and small arms. The research has led to the identification of several energetic compounds typically present on operational ranges including 2,4,6-trinitrotoluene (TNT), hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX), perchlorate, dinitrotoluene (DNT), nitroglycerin (NG), pentaerythritol tetranite (PETN) and associated transformation products of TNT. C1 USA, Corps Engineers, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03257 USA. RP Clausen, JL (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03257 USA. EM jay.l.clausen@us.army.mil NR 70 TC 1 Z9 1 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA SN 0097-6156 BN 978-0-8412-2632-6 J9 ACS SYM SER JI ACS Symp. Ser. PY 2011 VL 1069 BP 107 EP 136 PG 30 WC Chemistry, Multidisciplinary; Engineering, Environmental SC Chemistry; Engineering GA BDF54 UT WOS:000313022700006 ER PT S AU Taylor, S Lever, JH Fadden, J Bigl, SR Perron, NM Jones, KF Packer, B AF Taylor, Susan Lever, James H. Fadden, Jennifer Bigl, Susan R. Perron, Nancy M. Jones, Kathleen F. Packer, Bonnie BE Chappell, MA Price, CL George, RD TI Dissolution of High Explosives on Range Soils SO ENVIRONMENTAL CHEMISTRY OF EXPLOSIVES AND PROPELLANT COMPOUNDS IN SOILS AND MARINE SYSTEMS: DISTRIBUTED SOURCE CHARACTERIZATION AND REMEDIAL TECHNOLOGIES SE ACS Symposium Series LA English DT Proceedings Paper CT Symposium on Environmental Distribution, Degradation, and Mobility of Explosive and Propellant Compounds CY MAR 22-25, 2009 CL Salt Lake City, UT SP ACS, Div Environm Chem ID AIR WEAPONS RANGE; COMPOSITION-B; TNT; WATER; PARTICLES; TRANSPORT; KINETICS; RATES; RDX AB High explosives (HE) are deposited onto military range soils by live-fire training. A critical problem facing range managers is how to determine if explosives from training activities are likely to migrate off base, an outcome that might trigger federal regulatory actions able to close the base or restrict the type of training permitted. Partial detonations scatter most of the HE mass available for dissolution onto range soils as mm- to cm-sized particles. These particles are dissolved by contact with precipitation such as rain or snow, and the dissolved HE is transported to groundwater that can migrate off base. Our laboratory and outdoor tests mimic rainfall-driven dissolution of HE. We can model the effluent concentration given the starting mass of the HE particle and the rainfall record. Our tests revealed that photo-transformation and particle breakage, processes inherent to outdoor dissolution, greatly influence the amount of HE dissolved and hence the HE influx to soil. C1 [Taylor, Susan; Lever, James H.; Fadden, Jennifer; Bigl, Susan R.; Perron, Nancy M.; Jones, Kathleen F.] Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Taylor, S (reprint author), Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Susan.Taylor@usace.army.mil NR 44 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA SN 0097-6156 BN 978-0-8412-2632-6 J9 ACS SYM SER JI ACS Symp. Ser. PY 2011 VL 1069 BP 139 EP 155 PG 17 WC Chemistry, Multidisciplinary; Engineering, Environmental SC Chemistry; Engineering GA BDF54 UT WOS:000313022700007 ER PT S AU Pennington, JC Lotufo, G Hayes, CA Porter, B George, RD AF Pennington, Judith C. Lotufo, Guilherme Hayes, Charolett A. Porter, Beth George, Robert D. BE Chappell, MA Price, CL George, RD TI TNT, RDX, and HMX Association with Organic Fractions of Marine Sediments and Bioavailability Implications SO ENVIRONMENTAL CHEMISTRY OF EXPLOSIVES AND PROPELLANT COMPOUNDS IN SOILS AND MARINE SYSTEMS: DISTRIBUTED SOURCE CHARACTERIZATION AND REMEDIAL TECHNOLOGIES SE ACS Symposium Series LA English DT Proceedings Paper CT Symposium on Environmental Distribution, Degradation, and Mobility of Explosive and Propellant Compounds CY MAR 22-25, 2009 CL Salt Lake City, UT SP ACS, Div Environm Chem ID N-15 NMR-SPECTROSCOPY; COVALENT BINDING; SOIL AB Explosives may enter marine environments from unexploded ordnance, thus the potential for marine sediments to act as a sink for released explosives was evaluated. Relative distributions of TNT, RDX, and HMX in volatile, overlying water, pore water and sediment compartments were quantified, and their respective partitioning behaviors into various components of organic matter in marine sediments were determined. Marine sediments were incubated with radiolabeled explosives, held at 15 C for periods varying from 1 to 90 days and fractionated to the solvent extractable, cellulose, fulvic acid (FA), humic acid (HA), and humin organic carbon sediment pools. Studies of incubated sediment systems designed to trap CO2 and volatile organic compounds were also performed. For TNT and RDX, sediment is the principal sink, whereas for HMX, mineralization to CO2 is important. Mineralization is negligible for TNT, but significant for RDX. Contact time with sediment had a decreasing effect on the bioavailability of TNT, RDX, and HMX. C1 [Pennington, Judith C.; Lotufo, Guilherme] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Pennington, JC (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM robert.george@navy.mil NR 9 TC 1 Z9 1 U1 0 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA SN 0097-6156 BN 978-0-8412-2632-6 J9 ACS SYM SER JI ACS Symp. Ser. PY 2011 VL 1069 BP 185 EP 195 PG 11 WC Chemistry, Multidisciplinary; Engineering, Environmental SC Chemistry; Engineering GA BDF54 UT WOS:000313022700010 ER PT S AU Douglas, TA Walsh, ME McGrath, CJ Weiss, CA Jaramillo, AM Trainor, TP AF Douglas, Thomas A. Walsh, Marianne E. McGrath, Christian J. Weiss, Charles A., Jr. Jaramillo, Ashley Marie Trainor, Thomas P. BE Chappell, MA Price, CL George, RD TI The Fate of Nitroaromatic (TNT) and Nitramine (RDX and HMX) Explosive Residues in the Presence of Pure Metal Oxides SO ENVIRONMENTAL CHEMISTRY OF EXPLOSIVES AND PROPELLANT COMPOUNDS IN SOILS AND MARINE SYSTEMS: DISTRIBUTED SOURCE CHARACTERIZATION AND REMEDIAL TECHNOLOGIES SE ACS Symposium Series LA English DT Proceedings Paper CT Symposium on Environmental Distribution, Degradation, and Mobility of Explosive and Propellant Compounds CY MAR 22-25, 2009 CL Salt Lake City, UT SP ACS, Div Environm Chem ID CLAY-MINERALS; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE RDX; 2,4,6-TRINITROTOLUENE TNT; ABIOTIC TRANSFORMATION; LIVE-FIRE; SOIL; ADSORPTION; WATER; DEGRADATION; DISSOLUTION AB Packed beds of six different, granular, pure, metal oxide phases were loaded with explosives through controlled proximal detonation of Composition B. Composition B contains the commonly used explosives 2,4,6-trinitrotoluene (TNT), hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), and octahydro 1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX). The metal oxides examined include magnetite (Fe3O4; Fe[II] and 2Fe[III]), two different hematites (Fe2O3; Fe[III]), manganese oxide (MnO; Mn[II]), pyrolusite (MnO2; Mn[IV]), and aluminum oxide (Al2O3; Al[III]). These metal oxides were selected because of their potential to promote reductive transformation of explosive compounds. Following detonation subsamples of surficial and bulk metal oxides were mixed in aqueous batches using ultraclean water and monitored for TNT, RDX, HMX, 2ADNT, and 4ADNT concentrations for 149 days. Our results suggest that, even with highly controlled detonations, the explosive residues are heterogeneously loaded to the pure mineral phases. A logarithmic equation provides the best-fit description of the temporal trends in explosive analyte concentrations in the aqueous batches. RDX behaves more conservatively than TNT but does exhibit some loss from solution over time. Batches containing detonated magnetite and manganese oxide yielded the greatest loss of TNT, RDX, and HMX from solution and the highest 2ADNT and 4ADNT concentrations in the mineral material at the end of the batch experiments. These two batches also yielded the highest concentrations of the nitroso transformation products of RDX. This result suggests that reduced valence Fe and Mn metals promote explosive compound transformation, likely serving as a source of electrons for reductive transformation. C1 [Douglas, Thomas A.; Jaramillo, Ashley Marie] USA, Army Engn Res & Dev Ctr, Cold Regions Res & Engn Lab, Ft Wainwright, AK 99703 USA. RP Douglas, TA (reprint author), USA, Army Engn Res & Dev Ctr, Cold Regions Res & Engn Lab, POB 35170, Ft Wainwright, AK 99703 USA. EM Thomas.A.Douglas@usace.army.mil NR 40 TC 1 Z9 1 U1 4 U2 16 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA SN 0097-6156 BN 978-0-8412-2632-6 J9 ACS SYM SER JI ACS Symp. Ser. PY 2011 VL 1069 BP 197 EP 215 PG 19 WC Chemistry, Multidisciplinary; Engineering, Environmental SC Chemistry; Engineering GA BDF54 UT WOS:000313022700011 ER PT S AU Chappell, MA Price, CL Bourne, GG Pettway, BA Porter, BE AF Chappell, Mark A. Price, Cynthia L. Bourne, Gerald G. Pettway, Brad A. Porter, Beth E. BE Chappell, MA Price, CL George, RD TI Soil Vadose Zone Chemistry of TNT and RDX Under Water-Saturated Conditions SO ENVIRONMENTAL CHEMISTRY OF EXPLOSIVES AND PROPELLANT COMPOUNDS IN SOILS AND MARINE SYSTEMS: DISTRIBUTED SOURCE CHARACTERIZATION AND REMEDIAL TECHNOLOGIES SE ACS Symposium Series LA English DT Proceedings Paper CT Symposium on Environmental Distribution, Degradation, and Mobility of Explosive and Propellant Compounds CY MAR 22-25, 2009 CL Salt Lake City, UT SP ACS, Div Environm Chem ID CONSTITUENTS; HYDRATION; SORPTION; FATE AB Here, we describe experiments investigating the mobility and fate of TNT and RDX in elongated soil columns in order to simulate potential reactions as these munition constituents move down through the soil profile. Plexiglas columns (24 x 8 in) were dry-packed with a Memphis silt soil to a bulk density of 1.18 g cm(-3) and leached at a constant rate with a proportional mixture of TNT and RDX representing the explosive formulation, Composition B. Samples were collected with time from three sampling ports (labeled top, middle, and bottom) located down the height of the soil column using rhizome samplers. Solute breakthrough data was determined and modeled using a two-site non-equilibrium adsorption model. TNT was shown to become increasingly partitioned to the soil immobile phase with depth, which was attributed to the degradation and subsequent humification of ammonium-based degradation products. On the other hand, RDX was largely unaffected by its interaction with this soil. The KD value of RDX determined for the mobility experiments was similar to that determined in batch sorption isotherms. This study demonstrates the potential opportunities for transformation of munition constituents as the solutes traverse the soil profile. C1 [Chappell, Mark A.; Price, Cynthia L.] USA, ERDC, Vicksburg, MS USA. RP Chappell, MA (reprint author), USA, ERDC, 3909 Halls Ferry Rd, Vicksburg, MS USA. EM mark.a.chappell@usace.army.mil NR 14 TC 1 Z9 1 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA SN 0097-6156 BN 978-0-8412-2632-6 J9 ACS SYM SER JI ACS Symp. Ser. PY 2011 VL 1069 BP 217 EP 227 PG 11 WC Chemistry, Multidisciplinary; Engineering, Environmental SC Chemistry; Engineering GA BDF54 UT WOS:000313022700012 ER PT S AU Price, RA Bourne, M Price, CL Lindsay, J Cole, J AF Price, Richard A. Bourne, Michelle Price, Cynthia L. Lindsay, Jay Cole, Jim BE Chappell, MA Price, CL George, RD TI Transport of RDX and TNT from Composition-B Explosive During Simulated Rainfall SO ENVIRONMENTAL CHEMISTRY OF EXPLOSIVES AND PROPELLANT COMPOUNDS IN SOILS AND MARINE SYSTEMS: DISTRIBUTED SOURCE CHARACTERIZATION AND REMEDIAL TECHNOLOGIES SE ACS Symposium Series LA English DT Proceedings Paper CT Symposium on Environmental Distribution, Degradation, and Mobility of Explosive and Propellant Compounds CY MAR 22-25, 2009 CL Salt Lake City, UT SP ACS, Div Environm Chem ID DISSOLUTION; RANGES AB A complete understanding of the fate of munitions constituents (MC) on U.S. Army training lands is needed to develop the fundamental framework for the contaminant transport, transformation and fate (CTT&F) model for predicting the impacts of training activities on the distribution of MC in the environment. Explosive compounds RDX, TNT, and HMX derived from Composition-B explosive are of particular concern due to their toxicity potential and widespread use. This study evaluated distribution of these compounds from particulate Composition-B (Comp-B) following simulated rainfall in soil and plant mesocosms. Initial studies evaluated dissolution of MC from Comp-B with mass of Comp-B to water ratios ranging from 0.0125% to 12.5% and found soluble RDX and TNT was limited to < 5 mg L-1. When Comp-B was agitated in suspended soil particles in runoff elutriates for 30 min, soluble RDX, HMX and TNT generally increased in clay, loam and sandy loam soils except for reduced RDX and no detectable HMX in sandy loam soil. Significantly lower soil calcium and/or higher iron in the sandy loam soil may have contributed to the reduced RDX and HMX. Rainfall simulations were conducted on soil plant mesocosms with bare upland soil, vegetated upland soil, and vegetated wetland soil in a flow through system to monitor fate and transport of MC from Comp-B placed on the bare upland soil. The purpose of this was to determine effects of vegetated buffer zones on MC transport during rainfall events. Soluble concentrations of RDX and HMX were detected in runoff discharge from the bare upland soil but were significantly reduced following discharge through upland and wetland vegetation. TNT exhibited the greatest reduction in overland flow through upland vegetation with no detectable concentrations in discharge from the wetland. RDX and TNT were distributed in soil following overland flow of simulated rainfall with the higher concentrations remaining near the source zone. Upland plants had RDX and HINIX concentrations exceeding soil concentrations indicating the plant uptake was a major route of RDX and HMX removal from the system. Following continued plant interaction with the RDX, HMX and TNT laden soils, dormant vegetation contained higher concentrations of RDX and HMX which was subsequently leached from the tissue to non-detectable concentrations after three rainfall events. These results indicate that the fate and transport of RDX, HMX and TNT in surface water runoff may be controlled by a number of complex, interacting factors including various soil chemical and physical properties, plant uptake and adsorption, and seasonal influences on release from cellulose residues. Further research is needed to quantify kinetics of adsorption, uptake degradation and release in vegetated systems. C1 [Price, Richard A.; Bourne, Michelle; Price, Cynthia L.] USA, ERDC, Vicksburg, MS 39180 USA. RP Price, RA (reprint author), USA, ERDC, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM RichardA.Price@usace.army.mil NR 15 TC 0 Z9 0 U1 1 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA SN 0097-6156 BN 978-0-8412-2632-6 J9 ACS SYM SER JI ACS Symp. Ser. PY 2011 VL 1069 BP 229 EP + PG 13 WC Chemistry, Multidisciplinary; Engineering, Environmental SC Chemistry; Engineering GA BDF54 UT WOS:000313022700013 ER PT S AU Zhang, ZL Johnson, BE AF Zhang, Zhonglong Johnson, Billy E. BE Chappell, MA Price, CL George, RD TI The Contaminant Transport, Transformation, and Fate Sub-Model for Predicting the Site-Specific Behavior of Distributed Sources (Munitions Constituents) on US Army Training and Testing Ranges SO ENVIRONMENTAL CHEMISTRY OF EXPLOSIVES AND PROPELLANT COMPOUNDS IN SOILS AND MARINE SYSTEMS: DISTRIBUTED SOURCE CHARACTERIZATION AND REMEDIAL TECHNOLOGIES SE ACS Symposium Series LA English DT Proceedings Paper CT Symposium on Environmental Distribution, Degradation, and Mobility of Explosive and Propellant Compounds CY MAR 22-25, 2009 CL Salt Lake City, UT SP ACS, Div Environm Chem ID SURFACE-RUNOFF; OVERLAND-FLOW; SOIL; SEDIMENT; WATER; DISSOLUTION; CHEMICALS; POLLUTION; RIVER AB Contaminant Transport, Transformation and Fate (CTT&F) sub-model was developed for coupling with existing watershed hydrological modeling systems to predict the site-specific behavior of distributed sources (munitions constituents) on U.S. Army training and testing ranges. Physical transport and transformation processes across the land surface are simulated using distributed approach and routed through channels to the watershed outlet. The CTT&F sub-model includes the ability to represent explosive contaminant processes at the watershed scale including: partitioning of contaminants to solid particles, freely dissolved, dissolved organic carbon (DOC) bound dissolved, and sediment sorbed particulates, erosion and settling of particle associated contaminants, diffusive and mixing exchanges across the water column and upper soil (sediment) interface. CTT&F has the capability to simulate biodegradation, hydrolysis, oxidation, photolysis, volatilization, dissolution, and other transformation processes. To demonstrate model capabilities, CTT&F was coupled with a Gridded Surface Subsurface Hydrologic Analysis (GSSHA) model, then tested and validated to simulate RDX and TNT transport and transformation using two experimental plots. These experiments examined dissolution of solid contaminants into the dissolved phase and their subsequent transport to the plot outlet. Model results were in close agreement with measured data. Such model can be used to forecast the fate of munitions constituents within and transported from training ranges and to assess range management strategies to protect human and environmental health. C1 [Zhang, Zhonglong] USA, BTS, Environm Lab, Engn Res & Dev Ctr,CEERD EP W, Vicksburg, MS 39180 USA. RP Zhang, ZL (reprint author), USA, BTS, Environm Lab, Engn Res & Dev Ctr,CEERD EP W, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM zhonglong.zhang@usace.army.mil NR 42 TC 0 Z9 0 U1 1 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA SN 0097-6156 BN 978-0-8412-2632-6 J9 ACS SYM SER JI ACS Symp. Ser. PY 2011 VL 1069 BP 241 EP 272 PG 32 WC Chemistry, Multidisciplinary; Engineering, Environmental SC Chemistry; Engineering GA BDF54 UT WOS:000313022700014 ER PT S AU Clausen, JL Korte, N AF Clausen, J. L. Korte, Nic BE Chappell, MA Price, CL George, RD TI Fate and Transport of Energetics from Surface Soils to Groundwater SO ENVIRONMENTAL CHEMISTRY OF EXPLOSIVES AND PROPELLANT COMPOUNDS IN SOILS AND MARINE SYSTEMS: DISTRIBUTED SOURCE CHARACTERIZATION AND REMEDIAL TECHNOLOGIES SE ACS Symposium Series LA English DT Proceedings Paper CT Symposium on Environmental Distribution, Degradation, and Mobility of Explosive and Propellant Compounds CY MAR 22-25, 2009 CL Salt Lake City, UT SP ACS, Div Environm Chem ID MUNICIPAL ANAEROBIC SLUDGE; PACKED-BED BIOREACTORS; ARMY-AMMUNITION-PLANT; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE RDX; 2,4,6-TRINITROTOLUENE TNT; TRANSFORMATION PRODUCTS; DISSOLUTION RATES; CONTAMINATED SOIL; WATER SLURRIES; POPLAR TREES AB The principal energetic compounds found at military ranges include hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX), and perchlorate. These are found in rocket, artillery, grenade, and mortar Impact Areas as well as Open Burn/Open Detonation (OB/OD) and Explosive and Ordnance Disposal (EOD) sites. RDX, HMX, and perchlorate are persistent and mobile in aerobic aquatic environments with the primary fate-and-transport mechanisms being advection, dispersion, and dilution. Other compounds frequently detected in soil but less frequently in groundwater include 2-amino-4,6-dinitrotoluene (2a-DNT), 4-amino-2,6-dinitrotoluene (4a-DNT), 2,4-dintrotoulene (2,4-DNT), 2,6-dinitrotoluene (2,6-DNT), nitroglycerin (NG), and 2,4,6-trinitrotoluene (TNT). These compounds are more susceptible to phototransformation, biotransformation, and adsorption than HMX, RDX, and perchlorate, and with the exception of TNT, are typically released in much smaller amounts. TNT and the amino-DNTs are typically found in Impact Areas, OB/OD, and EOD sites. In contrast, DNTs and NG are found principally at artillery and mortar and small arms firing positions while NG is most common at anti-tank rocket firing positions. C1 [Clausen, J. L.] USA, Corps Engineers, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03257 USA. RP Clausen, JL (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03257 USA. EM jay.l.clausen@us.army.mil NR 180 TC 0 Z9 0 U1 1 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA SN 0097-6156 BN 978-0-8412-2632-6 J9 ACS SYM SER JI ACS Symp. Ser. PY 2011 VL 1069 BP 273 EP 316 PG 44 WC Chemistry, Multidisciplinary; Engineering, Environmental SC Chemistry; Engineering GA BDF54 UT WOS:000313022700015 ER PT S AU Price, CL Chappell, MA Pettway, BA Porter, BE AF Price, Cynthia L. Chappell, Mark A. Pettway, Brad A. Porter, Beth E. BE Chappell, MA Price, CL George, RD TI Potential Anaerobic Bioremediation of Perchlorate-Contaminated Soils through Biosolids Applications SO ENVIRONMENTAL CHEMISTRY OF EXPLOSIVES AND PROPELLANT COMPOUNDS IN SOILS AND MARINE SYSTEMS: DISTRIBUTED SOURCE CHARACTERIZATION AND REMEDIAL TECHNOLOGIES SE ACS Symposium Series LA English DT Proceedings Paper CT Symposium on Environmental Distribution, Degradation, and Mobility of Explosive and Propellant Compounds CY MAR 22-25, 2009 CL Salt Lake City, UT SP ACS, Div Environm Chem ID BIODEGRADATION; REDUCTION; BACTERIA AB The enzyme-mediated degradation of perchlorate has been show to occur by the following pathway; perchlorate to chlorate to chlorite to chloride. The typically low sorptive retention promotes the traditional view that perchlorate degradation is strictly a solution phase, biotic phenomenon. Yet, little is known about the potential interaction chemistry of perchlorate with the soil surface. For this study we incubated an Fe-rich soil at 30% moisture. Replicates were sacrificed with time and extracted with dilute sodium nitrate. Results show that perchlorate was significantly reduced over the 10-week incubation period and was accompanied by increase in chloride concentrations. No perchlorate decrease was seen in controls that contained no biosolids, indicating perchlorate removal in the treated soils may be attributed to biodegradation. C1 [Price, Cynthia L.; Chappell, Mark A.] USA, ERDC, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. [Pettway, Brad A.; Porter, Beth E.] SpecPro Inc, Huntsville, AL 35805 USA. RP Price, CL (reprint author), USA, ERDC, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Cynthia.L.Price@usace.army.mil NR 19 TC 0 Z9 0 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA SN 0097-6156 BN 978-0-8412-2632-6 J9 ACS SYM SER JI ACS Symp. Ser. PY 2011 VL 1069 BP 355 EP + PG 3 WC Chemistry, Multidisciplinary; Engineering, Environmental SC Chemistry; Engineering GA BDF54 UT WOS:000313022700018 ER PT S AU Price, RA Bourne, M AF Price, Richard A. Bourne, Michelle BE Chappell, MA Price, CL George, RD TI Effects of Wildfire and Prescribed Burning on Distributed Particles of Composition-B Explosive on Training Ranges SO ENVIRONMENTAL CHEMISTRY OF EXPLOSIVES AND PROPELLANT COMPOUNDS IN SOILS AND MARINE SYSTEMS: DISTRIBUTED SOURCE CHARACTERIZATION AND REMEDIAL TECHNOLOGIES SE ACS Symposium Series LA English DT Proceedings Paper CT Symposium on Environmental Distribution, Degradation, and Mobility of Explosive and Propellant Compounds CY MAR 22-25, 2009 CL Salt Lake City, UT SP ACS, Div Environm Chem ID TNT; RDX; PLANTS; SOIL; FATE AB Residual ordnance compounds may exist on artillery training areas after low-order detonations. Particles of Composition-B (Comp-B) explosives distributed on training ranges could potentially be a source of RDX, TNT, HMX and their degradation products in various migration pathways such as leaching, surface runoff and biological exposure. Several studies have been conducted to identify toxicity and potential risks of munitions compounds to human and ecological receptors. However, little research has been conducted to quantify the effects of natural processes on the persistence of these and other materials used in military training activities. One such process is the occurrence of incidental or controlled burning of vegetation on training lands that theoretically could provide a remedial effect on residual Comp-B explosive on surface soils. Battelle Memorial Institute (under SERDP Work Unit CP-1305) evaluated effects of fire on subsurface concentrations of RDX and TNT in soil and found that under normal burn conditions on training ranges, thermal degradation did not occur a couple centimeters below the soil surface. This study evaluated the effects of fire on the fate of surface-distributed particulate Comp B explosive that would result from low-order detonations on training ranges. Initial tests were conducted in a wind tunnel by placing pre-weighed 1 to 2-g particles of Comp-B explosive on the soil surface of vegetated test cells measuring 1.2 x 4.8 m. Vegetation was then ignited and burned under various vegetation moisture and wind speed conditions. Loss of Comp-B particles was determined both by weight loss of recovered particles and chemical analysis of surface soil. Soil surface temperatures were measured at the soil surface and generally peaked at less than 176 deg C. Most Comp-B particles were easily ignited in the wind tunnel burns, and where complete ignition of particles occurred, chemical analysis confirmed residual Comp-B parent and degradation compounds were less than 3% of original mass. Plot-scale studies were conducted on unconfined 12 x 12 m plots following procedures describe above and confirmed wind tunnel results. Field evaluations were conducted during controlled burns at Forts McCoy, Pickett, Stewart, and Camp Shelby,and resulted in reductions ranging from 79-to 100%. Variations in vegetative biomass, moisture conditions, wind speeds, and other factors affected burn temperature and duration, ultimately controlling exposure of Comp-B particles to sufficient heat/spark for ignition. However, these tests verified that controlled or incidental burns can significantly remove residual Comp-B from training ranges, minimizing potential adverse impacts these materials can pose to the environment. C1 [Price, Richard A.; Bourne, Michelle] USA, ERDC, Vicksburg, MS 39180 USA. RP Price, RA (reprint author), USA, ERDC, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM richard.a.price@usace.army.mil NR 20 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA SN 0097-6156 BN 978-0-8412-2632-6 J9 ACS SYM SER JI ACS Symp. Ser. PY 2011 VL 1069 BP 363 EP 377 PG 15 WC Chemistry, Multidisciplinary; Engineering, Environmental SC Chemistry; Engineering GA BDF54 UT WOS:000313022700019 ER PT J AU Larson, SL Martin, WA Griggs, CS Thompson, M Nestler, CC AF Larson, Steven L. Martin, W. Andy Griggs, Christopher S. Thompson, Michelle Nestler, Catherine C. TI Comparison of Lead Dissolution from Antique and Modern Ammunition SO ENVIRONMENTAL FORENSICS LA English DT Article DE weathering; scanning electron microscopy; dissolution; lead; corrosion; small arms firing ranges ID SHOOTING-RANGE; SOILS; TUNGSTEN; FLORIDA; USA AB Through space revitalization, small arms firing ranges of older bases have and may become incorporated into residential areas of active bases with possible human exposure to lead. Bullet dissolution and scanning electron microscopy studies compared weathering of lead from antique small arms ammunition (the 45/70-405 Government) and modern ammunition (5.56 mm). The almost pure lead in the 45/70 bullet resulted in a round that has a lower corrosion and dissolution rate than the lead/antimony alloy of modern ammunition. It is less likely that lead will migrate from the older ranges into the surrounding environment either with suspended solids carried by surface water runoff or through leaching into the underlying soil and groundwater. C1 [Nestler, Catherine C.] Appl Res Associates Inc, Vicksburg, MS 39180 USA. [Larson, Steven L.; Martin, W. Andy; Griggs, Christopher S.; Thompson, Michelle] USA, Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Nestler, CC (reprint author), Appl Res Associates Inc, 119 Monument Pl, Vicksburg, MS 39180 USA. EM cnestler@ara.com FU U.S. Army FX This research has not been submitted or published elsewhere. Portions of this research were presented at the 20th Annual AEHS Meeting and International Conference on Soils, Sediments Water, and Energy (March 15-18, 2010, San Diego, CA). The use of trade, product, or firm names in this report are for descriptive purposes only and does not imply the endorsement of the U. S. Government. The findings in this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. Financial support for this project was provided by the U.S. Army, Environmental Quality Technology (EQT) Program. We would like to thank Ms. Tarmiko Graham (Jackson State University, Jackson, MS), and Ms. Kimberly Powell (Mississippi College, Clinton, MS), for their technical support. NR 33 TC 4 Z9 4 U1 1 U2 10 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1527-5922 J9 ENVIRON FORENSICS JI Environ. Forensics PY 2011 VL 12 IS 2 BP 149 EP 155 AR PII 938620258 DI 10.1080/15275922.2011.572952 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA 779VS UT WOS:000291810900005 ER PT J AU Hadley, PW Crapps, E Hewitt, AD AF Hadley, Paul W. Crapps, Earl Hewitt, Alan D. TI Time for a Change of Scene SO ENVIRONMENTAL FORENSICS LA English DT Article DE incremental sampling; soil contamination ID HEALTH-BASED APPROACH; CONTACT CRITERION; HAZARDOUS-WASTE; SOILS AB Since the inception of the global effort to remediate contaminated sites back in the 1970s, countless millions of soil samples have been collected and sent to laboratories for chemical analysis. Most of those soil samples were collected as discrete samples, and despite the efforts of those who collected them, the sampling results were often difficult at best to interpret. Relatively recently some professionals in the environmental field have advanced an approach generally known as incremental sampling. Incremental sampling tackles head-on many of the thorny issues that challenge every soil sampling campaign, and it is finding wider acceptance. The time is ripe for a national-or perhaps even international-dialogue concerning incremental sampling, particularly as it seems to address many of the shortcomings of common soil sampling practices. C1 [Hadley, Paul W.] Calif Dept Tox Subst Control, Sacramento, CA 95812 USA. [Crapps, Earl] Alaska Dept Environm Conservat, Anchorage, AK USA. [Hewitt, Alan D.] USA, Corps Engineers Cold Reg Res & Engn Lab, Hanover, NH USA. RP Hadley, PW (reprint author), Calif Dept Tox Subst Control, POB 806, Sacramento, CA 95812 USA. EM phadley@dtsc.ca.gov NR 14 TC 3 Z9 3 U1 0 U2 4 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1527-5922 J9 ENVIRON FORENSICS JI Environ. Forensics PY 2011 VL 12 IS 4 BP 312 EP 318 DI 10.1080/15275922.2011.622344 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA 888JI UT WOS:000299999400003 ER PT J AU Ela, WP Sedlak, DL Barlaz, MA Henry, HF Muir, DCG Swackhamer, DL Weber, EJ Arnold, RG Ferguson, PL Field, JA Furlong, ET Giesy, JP Halden, RU Henry, T Hites, RA Hornbuckle, KC Howard, PH Luthy, RG Meyer, AK Saez, AE vom Saal, FS Vulpe, CD Wiesner, MR AF Ela, Wendell P. Sedlak, David L. Barlaz, Morton A. Henry, Heather F. Muir, Derek C. G. Swackhamer, Deborah L. Weber, Eric J. Arnold, Robert G. Ferguson, P. Lee Field, Jennifer A. Furlong, Edward T. Giesy, John P. Halden, Rolf U. Henry, Tala Hites, Ronald A. Hornbuckle, Keri C. Howard, Philip H. Luthy, Richard G. Meyer, Anita K. Saez, A. Eduardo vom Saal, Frederick S. Vulpe, Chris D. Wiesner, Mark R. TI Toward Identifying the Next Generation of Superfund and Hazardous Waste Site Contaminants SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article DE contaminants of emerging concern; emerging contaminant; hazardous waste site; Superfund ID POLYBROMINATED DIPHENYL ETHERS; PERSISTENT ORGANIC POLLUTANTS; BROMINATED FLAME RETARDANTS; WATER TREATMENT; DRINKING-WATER; QUANTITATIVE-DETERMINATION; EMERGING CONTAMINANTS; ESTROGENIC ACTIVITY; GREAT-LAKES; HOUSE-DUST AB BACKGROUND: This commentary evolved from a workshop sponsored by the National Institute of Environmental Health Sciences titled "Superfund Contaminants: The Next Generation" held in Tucson, Arizona, in August 2009. All the authors were workshop participants. OBJECTIVES: Our aim was to initiate a dynamic, adaptable process for identifying contaminants of emerging concern (CECs) that are likely to be found in future hazardous waste sites, and to identify the gaps in primary research that cause uncertainty in determining future hazardous waste site contaminants. DISCUSSION: Superfund-relevant CECs can be characterized by specific attributes: They are persistent, bioaccumulative, toxic, occur in large quantities, and have localized accumulation with a likelihood of exposure. Although still under development and incompletely applied, methods to quantify these attributes can assist in winnowing down the list of candidates from the universe of potential CECs. Unfortunately, significant research gaps exist in detection and quantification, environmental fate and transport, health and risk assessment, and site exploration and remediation for CECs. Addressing these gaps is prerequisite to a preventive approach to generating and managing hazardous waste sites. CONCLUSIONS: A need exists for a carefully considered and orchestrated expansion of programmatic and research efforts to identify, evaluate, and manage CECs of hazardous waste site relevance, including developing an evolving list of priority CECs, intensifying the identification and monitoring of likely sites of present or future accumulation of CECs, and implementing efforts that focus on a holistic approach to prevention. C1 [Ela, Wendell P.; Arnold, Robert G.; Saez, A. Eduardo] Univ Arizona, Tucson, AZ 85721 USA. [Sedlak, David L.] Univ Calif Berkeley, Berkeley, CA 94720 USA. [Barlaz, Morton A.] N Carolina State Univ, Raleigh, NC 27695 USA. [Henry, Heather F.] NIEHS, Superfund Res Program, Res Triangle Pk, NC 27709 USA. [Muir, Derek C. G.] Environm Canada, Aquat Ecosyst Protect Res Div, Burlington, ON L7R 4A6, Canada. [Swackhamer, Deborah L.] Univ Minnesota, Environm Hlth Sci Water Res Ctr, St Paul, MN 55108 USA. [Weber, Eric J.] US EPA, Natl Exposure Res Lab, Athens, GA USA. [Ferguson, P. Lee; Wiesner, Mark R.] Duke Univ, Durham, NC USA. [Field, Jennifer A.] Oregon State Univ, Corvallis, OR 97331 USA. [Furlong, Edward T.] US Geol Survey, Natl Water Qual Lab, Denver, CO 80225 USA. [Giesy, John P.] Univ Saskatchewan, Saskatoon, SK, Canada. [Halden, Rolf U.] Arizona State Univ, Sch Sustainable Engn & Built Environm, Tempe, AZ USA. [Halden, Rolf U.] Johns Hopkins Univ, Dept Environm Hlth Sci, Baltimore, MD 21205 USA. [Henry, Tala] US EPA, Natl Program Chem Div, Washington, DC 20460 USA. [Hites, Ronald A.] Indiana Univ, Bloomington, IN USA. [Hornbuckle, Keri C.] Univ Iowa, Iowa City, IA USA. [Howard, Philip H.] Syracuse Res Corp, Syracuse, NY USA. [Luthy, Richard G.] Stanford Univ, Stanford, CA 94305 USA. [Meyer, Anita K.] USA, Environm & Munit Ctr Expertise, Corps Engineers, Omaha, NE USA. [vom Saal, Frederick S.] Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA. [Vulpe, Chris D.] Univ Calif Berkeley, Berkeley, CA 94720 USA. RP Ela, WP (reprint author), Univ Arizona, 1133 E James E Rogers Way,POB 210011, Tucson, AZ 85721 USA. EM wela@engr.arizona.edu RI Furlong, Edward/C-3999-2011; Hornbuckle, Keri/A-8155-2008; Ferguson, Lee/A-5501-2013; Halden, Rolf/F-9562-2010; Saez, Avelino/K-1136-2016; OI Furlong, Edward/0000-0002-7305-4603; Hornbuckle, Keri/0000-0002-3478-3221; Halden, Rolf/0000-0001-5232-7361; Saez, Avelino/0000-0002-3548-6325; Muir, Derek/0000-0001-6631-9776 FU National Institute of Environmental Health Sciences [P42-ES04940] FX Support for the workshop, from which this article evolved, was provided by the National Institute of Environmental Health Sciences Superfund Research Program (P42-ES04940). NR 55 TC 9 Z9 9 U1 2 U2 66 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD JAN PY 2011 VL 119 IS 1 BP 6 EP 10 DI 10.1289/ehp.1002497 PG 5 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 701BI UT WOS:000285788900017 PM 21205582 ER PT J AU Perkins, EJ Chipman, JK Edwards, S Habib, T Falciani, F Taylor, R Van Aggelen, G Vulpe, C Antczak, P Loguinov, A AF Perkins, Edward J. Chipman, J. Kevin Edwards, Stephen Habib, Tanwir Falciani, Francesco Taylor, Ronald Van Aggelen, Graham Vulpe, Chris Antczak, Philipp Loguinov, Alexandre TI REVERSE ENGINEERING ADVERSE OUTCOME PATHWAYS SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article; Proceedings Paper CT SETAC Pellston Workshop CY APR 18-23, 2009 CL Forest Grove, OR SP SETAC DE Mechanism of action; Toxicology; Microarray; Network inference; Adverse outcome pathway ID BIOLOGICAL NETWORK INFERENCE; MINNOW PIMEPHALES-PROMELAS; GENE-EXPRESSION PROFILES; MOLECULAR NETWORKS; IN-VIVO; UNDERSTAND MECHANISMS; SIGNALING PATHWAY; SYSTEMS BIOLOGY; RISK-ASSESSMENT; TOXICITY AB The toxicological effects of many stressors are mediated through unknown or incompletely characterized mechanisms of action The application of reverse engineering complex interaction networks from high dimensional miles data (gene protein metabolic signaling) can be used to overcome these limitations This approach was used to characterize adverse outcome pathways (AOPs) for chemicals that disrupt the hypothalamus-pituitary gonadal endocrine axis in fathead minnows (FHM Pimephales promelas) Gene expression changes in FHM ovaries in response to seven different chemicals over different times doses and in vivo versus in vitro conditions were captured in a large data set of 868 arrays Potential AOPs of the antiandrogen flutamide were examined using two mutual information based methods to infer gene regulatory networks and potential AOPs Representative networks from these studies were used to predict network paths from stressor to adverse outcome as candidate AOPs The relationship of individual chemicals to an adverse outcome can be determined by following perturbations through the network in response to chemical treatment thus leading to the nodes associated with the adverse outcome Identification of candidate pathways allows for formation of testable hypotheses about key biological processes biomarkers or alternative endpoints that can be used to monitor an AOP Finally the unique challenges facing the application of this approach in ecotoxicology were identified and a road map for the utilization of these tools presented Environ Toxicol Chem 2011,30 22-38 (C) 2010 SETAC C1 [Perkins, Edward J.] USA, Engn Res & Dev Ctr, Vicksburg, MS USA. [Chipman, J. Kevin; Falciani, Francesco; Antczak, Philipp] Univ Birmingham, Birmingham, W Midlands, England. [Edwards, Stephen] US EPA, Res Triangle Pk, NC 27711 USA. [Habib, Tanwir] Univ So Mississippi, Hattiesburg, MS 39406 USA. [Taylor, Ronald] Pacific NW Natl Lab, Richland, WA 99352 USA. [Van Aggelen, Graham] Environm Canada, Vancouver, BC, Canada. [Vulpe, Chris; Loguinov, Alexandre] Univ Calif Berkeley, Berkeley, CA 94720 USA. RP Perkins, EJ (reprint author), USA, Engn Res & Dev Ctr, Vicksburg, MS USA. RI Antczak, Philipp/F-4517-2011 NR 97 TC 28 Z9 30 U1 6 U2 31 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD JAN PY 2011 VL 30 IS 1 BP 22 EP 38 DI 10.1002/etc.374 PG 17 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 701JM UT WOS:000285814200003 PM 20963852 ER PT J AU Sheridan, S Kalkstein, L Kalkstein, A Greene, S AF Sheridan, Scott Kalkstein, Laurence Kalkstein, Adam Greene, Scott TI Heat-related Mortality and Heat Watch-warning Systems in the United States: Recent Developments SO EPIDEMIOLOGY LA English DT Meeting Abstract CT Joint Conference of International-Society-of-Exposure-Science/International-Society-for-Envi ronmental-Epidemiology CY AUG 28-SEP 01, 2010 CL Seoul, SOUTH KOREA SP Int Soc Exposure Sci, Int Soc Environm Epidemiol C1 [Sheridan, Scott] Kent State Univ, Kent, OH 44242 USA. [Kalkstein, Laurence] Univ Miami, Coral Gables, FL 33124 USA. [Kalkstein, Adam] US Mil Acad, West Point, NY 10996 USA. [Greene, Scott] Univ Oklahoma, Norman, OK 73019 USA. NR 0 TC 2 Z9 2 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1044-3983 EI 1531-5487 J9 EPIDEMIOLOGY JI Epidemiology PD JAN PY 2011 VL 22 IS 1 SU S BP S13 EP S13 DI 10.1097/EDE.0b013e3181fa5ca1 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 695VN UT WOS:000285400800002 ER PT J AU Blue-Terry, M Letowski, T AF Blue-Terry, Misty Letowski, Tomasz TI Effects of white noise on Callsign Acquisition Test and Modified Rhyme Test scores SO ERGONOMICS LA English DT Article DE Callsign Acquisition Test; Modified Rhyme Test; speech intelligibility; white noise ID SPEECH; PERFORMANCE AB The Callsign Acquisition Test (CAT) is a speech intelligibility test developed by the US Army Research Laboratory. The test has been used to evaluate speech transmission through various communication systems but has not been yet sufficiently standardised and validated. The aim of this study was to compare CAT and Modified Rhyme Test (MRT) performance in the presence of white noise across a range of signal-to-noise ratios (SNRs). A group of 16 normal-hearing listeners participated in the study. The speech items were presented at 65 dB(A) in the background of white noise at SNRs of -18, -15, -12, -9 and -6 dB. The results showed a strong positive association (75.14%) between the two tests, but significant differences between the CAT and MRT absolute scores in the range of investigated SNRs. Based on the data, a function to predict CAT scores based on existing MRT scores and vice versa was formulated. Statement of Relevance: This work compares performance data of a common speech intelligibility test (MRT) with a new test (CAT) in the presence of white noise. The results here can be used as a part of the standardisation procedures and provide insights to the predictive capabilities of the CAT to quantify speech intelligibility communication in high-noise military environments. C1 [Blue-Terry, Misty] N Carolina Agr & Tech State Univ, Greensboro, NC 27420 USA. [Letowski, Tomasz] USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Blue-Terry, M (reprint author), N Carolina Agr & Tech State Univ, Greensboro, NC 27420 USA. EM mablue@ncat.edu NR 22 TC 3 Z9 3 U1 0 U2 4 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0014-0139 J9 ERGONOMICS JI Ergonomics PY 2011 VL 54 IS 2 BP 139 EP 145 DI 10.1080/00140139.2010.540354 PG 7 WC Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Engineering; Psychology GA 715XB UT WOS:000286926600003 PM 21294011 ER PT J AU Seay, JF Hasselquist, L Bensel, CK AF Seay, Joseph F. Hasselquist, Leif Bensel, Carolyn K. TI Carrying a rifle with both hands affects upper body transverse plane kinematics and pelvis-trunk coordination SO ERGONOMICS LA English DT Article DE biomechanics; coordination; locomotion; relative phase; rifle carriage ID MILITARY LOAD CARRIAGE; DYNAMICAL-SYSTEMS APPROACH; MEDICAL ASPECTS; RELATIVE PHASE; WALKING SPEED; GAIT; LOCOMOTION; PARAMETERS; TREADMILL; KINETICS AB The purpose of this study was to assess how carrying a rifle in both hands affects upper body motion and coordination during locomotion. In total, 11 male soldiers walked (1.34 m/s) and ran (2.46 m/s) with a weapon (M4 condition) and without a weapon (NW condition) while kinematic pelvis and trunk data were collected. Two-way ANOVA was used to compare segmental ranges of motion (ROM), pelvis-trunk coordination (continuous relative phase) and coordination variability between gait mode and weapon combinations. Carrying a weapon decreased sagittal plane trunk ROM at both speeds and increased trunk rotation during running. Mean (+/- SD) transverse plane coordination was more in-phase while carrying a weapon (M4 = 83 degrees +/- 31, NW = 60 degrees +/- 36, p = 0.027) and transverse plane coordination variability decreased (M4 = 23 degrees +/- 3.6, NW 15 degrees +/- 4.4, p = 0.043). Coordination differences between M4 and NW were similar to differences reported in the literature between individuals with and without back pain. Long-term injury implications due to decreased coordination variability are discussed. Statement of Relevance: Knowledge of the effects of rifle carriage on pelvis-trunk coordination may provide insight into short-term protective strategies and long-term injury mechanisms. These should be considered in occupations requiring individuals to carry torso loads in combination with holding an object in both hands that restricts arm swing. C1 [Seay, Joseph F.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Hasselquist, Leif; Bensel, Carolyn K.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Seay, JF (reprint author), USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. EM joseph.seay@us.army.mil NR 30 TC 5 Z9 5 U1 1 U2 7 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0014-0139 J9 ERGONOMICS JI Ergonomics PY 2011 VL 54 IS 2 BP 187 EP 196 DI 10.1080/00140139.2010.538726 PG 10 WC Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Engineering; Psychology GA 715XB UT WOS:000286926600008 PM 21294016 ER PT J AU Blank, SJ AF Blank, Stephen J. TI The 'Special' World: Stalin's Power Apparatus and the Soviet System's Secret Structures of Communication SO EUROPE-ASIA STUDIES LA English DT Book Review C1 [Blank, Stephen J.] USA, War Coll, Strateg Studies Inst, Carlisle, PA 17013 USA. RP Blank, SJ (reprint author), USA, War Coll, Strateg Studies Inst, 122 Forbes Ave, Carlisle, PA 17013 USA. EM Stephen.Blank@us.army.mil NR 1 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0966-8136 J9 EUROPE-ASIA STUD JI Eur.-Asia Stud. PY 2011 VL 63 IS 1 BP 164 EP 165 PG 2 WC Area Studies; Economics; Political Science SC Area Studies; Business & Economics; Government & Law GA 714NA UT WOS:000286815100013 ER PT J AU Honsell, G De Bortoli, M Boscolo, S Dell'Aversano, C Tartaglione, L Battocchi, C Penna, A Berti, F Fontanive, G Poli, M Sosa, S Yasumoto, T Tubaro, A AF Honsell, Giorgio De Bortoli, Marco Boscolo, Sabrina Dell'Aversano, Carmela Tartaglione, Luciana Battocchi, Cecilia Penna, Antonella Berti, Federico Fontanive, Giampaolo Poli, Mark Sosa, Silvio Yasumoto, Takeshi Tubaro, Aurelia TI OSTREOPSIS cf. OVATA (DINOPHYCEAE): TOXIN CONTENT, IMMUNOCYTOCHEMISTRY AND ULTRASTRUCTURE SO EUROPEAN JOURNAL OF PHYCOLOGY LA English DT Meeting Abstract C1 [Honsell, Giorgio] Univ Udine, Dept Agr & Environm Sci, I-33100 Udine, Italy. [De Bortoli, Marco; Sosa, Silvio; Tubaro, Aurelia] Univ Trieste, Mat & Nat Resources Dept, I-34127 Trieste, Italy. [Boscolo, Sabrina] Univ Trieste, Dept Life Sci, I-34127 Trieste, Italy. [Dell'Aversano, Carmela; Tartaglione, Luciana] Univ Naples Federico 2, Chem Nat Prod Dept, I-80161 Naples, Italy. [Battocchi, Cecilia; Penna, Antonella] Univ Urbino, Biomol Sci Dept, I-61029 Urbino, Italy. [Berti, Federico; Fontanive, Giampaolo] Univ Trieste, Chem & Pharmaceut Sci Dept, I-34127 Trieste, Italy. [Poli, Mark] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Yasumoto, Takeshi] Japan Food Res Labs, Tama Lab, Tama, Tokyo 2060025, Japan. EM giorgio.honsell@uniud.it; marco.DeBortoli@econ.units.it; sboscolo@units.it; dellaver@unina.it; antonella.penna@uniurb.it; fberti@units.it; mark.poli@us.army.mil; yasumotot@subtropics.or.jp; tubaro@units.it RI Dell'Aversano, Carmela/H-1803-2013 OI Dell'Aversano, Carmela/0000-0001-8337-3029 NR 0 TC 1 Z9 1 U1 0 U2 2 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0967-0262 J9 EUR J PHYCOL JI Eur. J. Phycol. PY 2011 VL 46 SU 1 SI SI BP 70 EP 70 PG 1 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA 880PF UT WOS:000299418700089 ER PT J AU Makela, A AF Makela, A. TI CAFFEINE RELATED DISORDERS: LEARNING FROM OUR PATIENTS SO EUROPEAN PSYCHIATRY LA English DT Meeting Abstract C1 [Makela, A.] Tripler Army Med Ctr, Dept Psychiat, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER PI PARIS PA 23 RUE LINOIS, 75724 PARIS, FRANCE SN 0924-9338 J9 EUR PSYCHIAT JI Eur. Psychiat. PY 2011 VL 26 SU 1 MA P01-77 PG 1 WC Psychiatry SC Psychiatry GA V27VS UT WOS:000208641300078 ER PT J AU Nayback-Beebe, AM AF Nayback-Beebe, A. M. TI THE INFLUENCE OF SOCIAL SUPPORT, CONFLICT, AND STRESSFUL LIFE EVENTS ON PTSD, DEPRESSION, AND ANXIETY SYMPTOM SEVERITY IN U. S. ARMY FEMALE VETERANS SO EUROPEAN PSYCHIATRY LA English DT Meeting Abstract C1 [Nayback-Beebe, A. M.] Brooke Army Med Ctr, Dept Nursing Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 4 PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER PI PARIS PA 23 RUE LINOIS, 75724 PARIS, FRANCE SN 0924-9338 J9 EUR PSYCHIAT JI Eur. Psychiat. PY 2011 VL 26 SU 1 MA P03-508 PG 1 WC Psychiatry SC Psychiatry GA V27VS UT WOS:000208641301778 ER PT J AU Manneck, T Braissant, O Ellis, W Keiser, J AF Manneck, Theresia Braissant, Olivier Ellis, William Keiser, Jennifer TI Schistosoma mansoni: Antischistosomal activity of the four optical isomers and the two racemates of mefloquine on schistosomula and adult worms in vitro and in vivo SO EXPERIMENTAL PARASITOLOGY LA English DT Article DE Mefloquine; Schistosoma mansoni; Isomer; Racemate; In vitro; In vivo; Microcalorimetry ID CHIRAL INVERSION; ABSOLUTE STEREOCHEMISTRY; PLASMODIUM-FALCIPARUM; ANTIMALARIAL AGENTS; TENEBRIO-MOLITOR; PRAZIQUANTEL; IBUPROFEN; INVITRO; DRUGS; CHEMOTHERAPY AB Recent studies have shown that mefloquine (MQ) reveals interesting antischistosomal properties. We examined the antischistosomal activities of the erythro and threo isomers and racemates of MQ on newly transformed schistosomula (NTS) and adult Schistosoma mansoni in vitro and in mice harbouring adult S. mansoni. The in vitro effects in the presence and absence of haemin were monitored by means of microcalorimetry, scanning electron microscopy and phenotypic evaluation. Incubation of NTS with the erythro derivatives at concentrations of 3 mu g/ml and above resulted in convulsions, granularity, decrease in heat flow, and death while NTS incubated with the threo derivatives were only affected at high concentrations (100 mu g/ml). Extensive tegumental alterations, decrease in metabolic activity, viability, and death were observed when adult schistosomes had been exposed to 10 mu g/ml of the erythro compounds. Moderate tegumental and viability changes but reduced heat production rates were observed with the threo derivatives at 10 mu g/ml. In the presence of haemin, all MQ derivatives showed pronounced antischistosomal properties against adult S. mansoni in vitro. In vivo, MQ derivatives achieved statistically significant total and female worm burden reductions ranging between 65.4% and 100%. The highest total worm burden reductions of 93.4% and 90.2% were observed following treatment with the erythro and threo racemates, respectively. In conclusion, the optical isomers and racemates of MQ show only moderate stereoselectivity, in particular in vivo. Our results may enhance our understanding of the mechanism of action and therapeutic profile of MQ derivates on schistosomes. (C) 2010 Elsevier Inc. All rights reserved. C1 [Manneck, Theresia; Keiser, Jennifer] Swiss Trop & Publ Hlth Inst, Dept Med Parasitol & Infect Biol, CH-4002 Basel, Switzerland. [Braissant, Olivier] Univ Basel, Pharmazentrum, Biozentrum, Lab Biomech & Biocalorimetry, CH-4003 Basel, Switzerland. [Ellis, William] Walter Reed Army Inst Res, Dept Chem Informat, Washington, DC 20314 USA. RP Keiser, J (reprint author), Swiss Trop & Publ Hlth Inst, Dept Med Parasitol & Infect Biol, POB, CH-4002 Basel, Switzerland. EM jennifer.keiser@unibas.ch RI Braissant, Olivier/H-2284-2012 OI Braissant, Olivier/0000-0003-0659-755X FU Swiss National Science Foundation [PPOOA-114941] FX This investigation received financial support from the Swiss National Science Foundation to T. M. and J. K. (project no. PPOOA-114941). We are grateful to Mireille Vargas for excellent technical assistance. The authors thank Dr. Dieter Wirz for helpful discussions on the microcalorimetric data analysis. We also thank Mr. Daniel Mathys, Mrs. Evi Bieler and Mr. Marcel Duggelin at the Centre for Microscopy at the University of Basel for expert help with the SEM studies. NR 35 TC 26 Z9 28 U1 1 U2 6 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0014-4894 J9 EXP PARASITOL JI Exp. Parasitol. PD JAN PY 2011 VL 127 IS 1 BP 260 EP 269 DI 10.1016/j.exppara.2010.08.011 PG 10 WC Parasitology SC Parasitology GA 710BV UT WOS:000286486800040 PM 20732321 ER PT J AU Petersen, K Waterman, P AF Petersen, Kyle Waterman, Paige TI Prophylaxis and treatment of infections associated with penetrating traumatic injury SO EXPERT REVIEW OF ANTI-INFECTIVE THERAPY LA English DT Review DE antibiotic; anti-infective agents; gunshot; infection; penetrating; prophylaxis; trauma; wounds ID OPERATION-ENDURING-FREEDOM; COMBAT-RELATED INJURIES; IN-VITRO ELUTION; PRACTICE MANAGEMENT GUIDELINES; INCREASED RESOURCE UTILIZATION; CENTRAL-NERVOUS-SYSTEM; OF-THE-LITERATURE; ABDOMINAL-TRAUMA; ANTIBIOTIC-THERAPY; TUBE THORACOSTOMY AB Accidents or violence can result in penetrating trauma in the adult population. Contaminated penetrating foreign bodies introduced at the time of wounding cause infection, especially high velocity projectiles, which result in cavitation. Surgical debridement reduces potential infection; however, perioperative antibiotics are usually indicated owing to studies demonstrating high rates of sepsis in the pre-antibiotic era. Trauma-associated pathogens include Gram-positive, Gram-negative and anaerobic pathogens. Antibiotic resistance is increasing, and several recent panels have sought to develop guidelines for perioperative prevention and empiric treatment of infection to limit usage and reduce selective pressure for resistance. We review infections of the CNS, thorax, abdomen and extremities following penetrating trauma injury, as well as the data supporting a reasonable antimicrobial approach. C1 [Petersen, Kyle] USN, Med Res Ctr, Undersea Med Dept, Silver Spring, MD 20910 USA. [Waterman, Paige] Walter Reed Army Inst Res, Dept Wound Infect, Silver Spring, MD 20910 USA. RP Petersen, K (reprint author), USN, Med Res Ctr, Undersea Med Dept, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM kyle.petersen@med.navy.mil NR 141 TC 10 Z9 14 U1 1 U2 6 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1478-7210 EI 1744-8336 J9 EXPERT REV ANTI-INFE JI Expert Rev. Anti-Infect. Ther. PD JAN PY 2011 VL 9 IS 1 BP 81 EP 96 DI 10.1586/ERI.10.155 PG 16 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 742VW UT WOS:000288974400015 PM 21171880 ER PT J AU Gruber, DD Hernandez, SL Wright, J Fischer, JR AF Gruber, Daniel D. Hernandez, Sandra L. Wright, Johnnie, Jr. Fischer, John R. TI Transobturator Tape Removal Using a Combined Vaginal-Transcutaneous Approach for Intractable Groin Pain SO FEMALE PELVIC MEDICINE AND RECONSTRUCTIVE SURGERY LA English DT Article DE transobturator tape; groin pain; dyspareunia; mesh removal; midurethral sling AB Background: Transient groin pain is a therapeutically challenging complication associated with transobturator sling procedures. Case: We present the case of a 37-year-old woman who presented with debilitating left groin pain and dyspareunia following placement of transobturator sling. Pelvic floor physical therapy, medications, and trigger point injections failed to provide relief. Workup included magnetic resonance imaging of the pelvis, complex cystometrics, and additional trigger point injections. Surgical removal of the complete left side of the tape including the portion imbedded in the obturator foramen was performed with a combined vaginal-transcutaneous approach. Extirpation of the mesh arm brought prompt and full resolution of the patient's symptoms. Conclusions: Surgical removal of the transobturator tape through the obturator foramen can be safely performed using a combined vaginal-transcutaneous approach. C1 [Gruber, Daniel D.; Hernandez, Sandra L.; Wright, Johnnie, Jr.; Fischer, John R.] Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Washington, DC 20307 USA. RP Gruber, DD (reprint author), Walter Reed Army Med Ctr, Dept Obstet & Gynecol, 6900 Georgia Ave, Washington, DC 20307 USA. EM ddgruber1@gmail.com NR 9 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2151-8378 J9 FEMALE PELVIC MED RE JI Female Pelvic Med. Reconstr. Surg. PD JAN-FEB PY 2011 VL 17 IS 1 BP 55 EP 57 DI 10.1097/SPV.0b013e318204490c PG 3 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA V35WM UT WOS:000209176000011 PM 22453673 ER PT J AU Cole, MW Alpay, SP AF Cole, M. W. Alpay, S. P. BE Lallart, M TI Performance Enhanced Complex Oxide Thin Films for Temperature Stable Tunable Device Applications: A Materials Design and Process Science Prospective SO FERROELECTRICS - MATERIAL ASPECTS LA English DT Article; Book Chapter ID BARIUM-STRONTIUM-TITANATE; PULSED-LASER DEPOSITION; DIELECTRIC-PROPERTIES; MICROWAVE APPLICATIONS; EPITAXIAL-GROWTH; HIGH TUNABILITY; INTEGRATION; GRADIENTS C1 [Cole, M. W.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Alpay, S. P.] Univ Connecticut, Mat Sci & Engn, Storrs, CT USA. RP Cole, MW (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. NR 48 TC 1 Z9 1 U1 0 U2 0 PU INTECH EUROPE PI RIJEKA PA JANEZA TRDINE9, RIJEKA, 51000, CROATIA BN 978-953-307-332-3 PY 2011 BP 149 EP 178 D2 10.5772/702 PG 30 WC Materials Science, Multidisciplinary; Physics, Condensed Matter SC Materials Science; Physics GA BG0YA UT WOS:000386572100009 ER PT J AU Csokmay, JM Hill, MJ Maguire, M Payson, MD Fujimoto, VY Armstrong, AY AF Csokmay, John M. Hill, Micah J. Maguire, Marcy Payson, Mark D. Fujimoto, Victor Y. Armstrong, Alicia Y. TI Are there ethnic differences in pregnancy rates in African-American versus white women undergoing frozen blastocyst transfers? SO FERTILITY AND STERILITY LA English DT Article DE Ethnicity; racial; disparities; live birth rate; infertility; IVF; ART ID ASSISTED REPRODUCTIVE TECHNOLOGY; BLACK-WOMEN; OUTCOMES; CARE AB Objective: To determine whether frozen-thawed blastocyst transfer pregnancy rates (PR) are lower in African-American compared with white women. Design: Retrospective review of frozen blastocyst cycles. Setting: University-based assisted reproductive technology (ART) program. Patient(s): All patients who underwent a frozen blastocyst transfer between 2003 and 2008. Intervention: None. Main Outcome Measure(s): Live birth rate. Result(s): One hundred sixty-nine patients underwent transfer of a frozen-thawed blastocyst. African-American women had a higher incidence of leiomyoma (40% vs. 10%) and tubal and uterine factor infertility. There was no difference in the live birth rate for African-American patients (28.0%) compared with white patients (30.2%). Of the patients who underwent a frozen-thawed blastocyst transfer, 58% (n = 98) had their fresh, autologous IVF cycle, which produced the cryopreserved blastocyst, at Walter Reed Medical Center. A higher peak serum E(2) level was noted in African-American patients (5,355 pg/mL) compared with white patients (4,541 pg/mL). During the fresh cycle, the live birth rates between African-American and white patients were significantly different at 16.7% versus 39.7%, respectively. Conclusion(s): Live birth rates after frozen blastocyst transfer are not different between African-American and white women despite a fourfold higher incidence of leiomyomas in African-American women. (Fertil Steril (R) 2011; 95: 89-93. (C)2011 by American Society for Reproductive Medicine.) C1 [Csokmay, John M.; Hill, Micah J.; Maguire, Marcy; Payson, Mark D.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Csokmay, John M.; Hill, Micah J.; Maguire, Marcy; Armstrong, Alicia Y.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Reprod Biol & Med Branch, NIH, Bethesda, MD USA. [Fujimoto, Victor Y.] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA 94143 USA. RP Armstrong, AY (reprint author), NICHD, NIH, 10 Ctr Dr,Bldg 10,CRC 1E-3140, Bethesda, MD 20892 USA. EM armstroa@mail.nih.gov FU National Institute of Child Health and Human Development-Uniformed Services University of the Health Sciences FX The authors acknowledge Jacques Cohen, Ph.D., Aidita James, Ph.D., Sasha Hennessey, B. S., Frederick Larsen, M. D., Donna Hoover, R.N., Darshana Naik, R.N., and fellows in the Reproductive Endocrine Fellowship at National Institute of Child Health and Human Development-Uniformed Services University of the Health Sciences for their support and contributions. NR 17 TC 9 Z9 9 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD JAN PY 2011 VL 95 IS 1 BP 89 EP 93 DI 10.1016/j.fertnstert.2010.03.050 PG 5 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 695ZL UT WOS:000285411600023 PM 20451186 ER PT J AU Maguire, M Csokmay, J Segars, J Payson, M Armstrong, A AF Maguire, Marcy Csokmay, John Segars, James Payson, Mark Armstrong, Alicia TI Enough is enough! Patients who do not conceive on 600 IU/d of gonadotropins show no improvement from an additional 150 IU of LH activity SO FERTILITY AND STERILITY LA English DT Editorial Material DE Luteinizing hormone; gonadotropin dose; pregnancy rate; miscarriage rate; cancellation rate ID IN-VITRO FERTILIZATION; POOR RESPONDERS; HORMONE; DOSAGE; FSH AB Studies have suggested that supplemental LH improves outcomes in assisted reproductive technology (ART) cycles. In this retrospective review, an additional 150 IU of LH activity did not improve ART outcomes in women undergoing a second round of IVF/ intracytoplasmic sperm injection (ICSI) after an initial failed cycle using 600 IU of gonadotropins. (Fertil Steril (R) 2011; 95:372-3. (c) 2011 by American Society for Reproductive Medicine.) C1 [Maguire, Marcy] NICHD, Program Reprod & Adult Endocrinol, NIH, Walter Reed Army Med Ctr,Natl Naval Med Ctr,CRC, Bethesda, MD 20892 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Maguire, M (reprint author), NICHD, Program Reprod & Adult Endocrinol, NIH, Walter Reed Army Med Ctr,Natl Naval Med Ctr,CRC, Bldg 10,Room 1E-3140,10 Ctr Dr, Bethesda, MD 20892 USA. EM maguiremf@mail.nih.gov FU Intramural NIH HHS [Z99 HD999999] NR 8 TC 2 Z9 2 U1 1 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD JAN PY 2011 VL 95 IS 1 BP 372 EP 373 DI 10.1016/j.fertnstert.2010.08.020 PG 2 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 695ZL UT WOS:000285411600098 PM 20850732 ER PT S AU Beresnev, LA Vorontsov, MA Weyrauch, T Carhart, G Lachinova, SL Liu, J AF Beresnev, Leonid A. Vorontsov, Mikhail A. Weyrauch, Thomas Carhart, Gary Lachinova, Svetlana L. Liu, Jiang BE Dawson, JW Honea, EC TI Experimental study of phase locking of fiber collimators using internal beam-tail interference. SO FIBER LASERS VIII: TECHNOLOGY, SYSTEMS, AND APPLICATIONS SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Fiber Lasers VIII - Technology, Systems, and Applications CY JAN 24-27, 2011 CL San Francisco, CA SP SPIE, NKT Photon A/S, Fianium Ltd, PolarOnyx Inc ID ARRAY AB Experimental study of internal phase locking of a seven fiber collimator array is presented. As a metric for the feedback loop the periphery areas (tails) of beams outgoing from three adjacent fiber tips are used before the beams are clipped by the lens apertures. The "intercepted" tails of beams are redirected back into the collimator array forming an interference pattern located between adjacent collimators. Optical energy from one region of the pattern is selected by a pinhole, detected with a photo-diode and used as a metric signal for an SPGD controller to lock the phase of the three adjacent beam tails. The non-common phase difference of the outgoing wavefronts from these three collimators can be manipulated by altering the position of the pinhole in focal plane of the interference pattern and is removed (set to "zero" or 2 pi increments) by a displacement selected to produce the expected far field interference pattern. To phase lock the beams from seven collimators arranged in a hexagonal array, three pinholes, each of which receives some light from the center collimator are used. A sum of the signals from the three photo-diodes placed behind these pinholes is used to lock the phase of the six periphery beams to the central uncontrolled reference without beam splitters or a remote target-in-the-loop metric. C1 [Beresnev, Leonid A.; Carhart, Gary; Liu, Jiang] USA, Res Lab, Adelphi, MD 20783 USA. RP Beresnev, LA (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM lberesnev@arl.army.mil NR 5 TC 2 Z9 2 U1 1 U2 4 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-451-2 J9 PROC SPIE PY 2011 VL 7914 AR 79142Z DI 10.1117/12.877300 PG 11 WC Optics; Physics, Applied SC Optics; Physics GA BYA86 UT WOS:000297791600084 ER PT J AU Finestone, A Milgrom, C Wolf, O Petrov, K Evans, R Moran, D AF Finestone, Aharon Milgrom, Charles Wolf, Omer Petrov, Kaloyan Evans, Rachel Moran, Daniel TI Epidemiology of Metatarsal Stress Fractures Versus Tibial and Femoral Stress Fractures During Elite Training SO FOOT & ANKLE INTERNATIONAL LA English DT Article DE Stress Fracture; Epidemiology; Metatarsal; Tibia; Femur; Long-Term Followup ID FATIGUE BEHAVIOR; STRAIN; BONE; RECRUITS AB Background: The training of elite infantry recruits takes a year or more. Stress fractures are known to be endemic in their basic training and the clinical presentation of tibial, femoral, and metatarsal stress fractures are different. Stress fracture incidence during the subsequent progressively more demanding training is not known. The study hypothesis was that after an adaptation period, the incidence of stress fractures during the course of 1 year of elite infantry training would fall in spite of the increasingly demanding training. Materials and Methods: Seventy-six male elite infantry recruits were followed for the development of stress fractures during a progressively more difficult training program composed of basic training (1 to 14 weeks), advanced training (14 to 26 weeks), and unit training (26 to 52 weeks). Subjects were reviewed regularly and those with clinical suspicion of stress fracture were assessed using bone scan and X-rays. Results: The incidence of stress fractures was 20% during basic training, 14% during advanced training and 23% during unit training. There was a statistically significant difference in the incidence of tibial and femoral stress fractures versus metatarsal stress fractures before and after the completion of phase II training at week 26 (p = 0.0001). Seventy-eight percent of the stress fractures during phases I and II training were either tibial or femoral, while 91% of the stress fractures in phase III training were metatarsal. Prior participation in ball sports (p = 0.02) and greater tibial length (p = 0.05) were protective factors for stress fracture. Conclusion: The study hypothesis that after a period of soldier adaptation, the incidence of stress fractures would decrease in spite of the increasingly demanding elite infantry training was found to be true for tibial and femoral fractures after 6 months of training but not for metatarsal stress fractures. Further studies are required to understand the mechanism of this difference but physicians and others treating stress fractures should be aware of this pattern. C1 [Milgrom, Charles; Petrov, Kaloyan] Hadassah Univ Hosp, IL-91120 Jerusalem, Israel. [Finestone, Aharon; Wolf, Omer; Moran, Daniel] Chaim Sheba Med Ctr, Israel Def Forces Med Corps, Heller Inst Mil Physiol, IL-52621 Tel Hashomer, Israel. [Evans, Rachel] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. RP Milgrom, C (reprint author), Hadassah Univ Hosp, IL-91120 Jerusalem, Israel. EM charlesm@ekmd.huji.ac.il OI Wolf, Omer/0000-0001-5419-4400; Finestone, Aharon/0000-0003-1956-5557 FU MRMC [W911QY-07-P0127] FX The study was supported by a contract from MRMC (No. W911QY-07-P0127). NR 14 TC 7 Z9 7 U1 0 U2 10 PU AMER ORTHOPAEDIC FOOT & ANKLE SOC, INC PI SEATTLE PA 2517 EASTLAKE AVE EAST, STE 200, SEATTLE, WA 98102 USA SN 1071-1007 J9 FOOT ANKLE INT JI Foot Ankle Int. PD JAN PY 2011 VL 32 IS 1 BP 16 EP 20 DI 10.3113/FAI.2011.0016 PG 5 WC Orthopedics SC Orthopedics GA 703NR UT WOS:000285986000004 PM 21288430 ER PT S AU Reinerman-Jones, L Taylor, G Cosenzo, K Lackey, S AF Reinerman-Jones, Lauren Taylor, Grant Cosenzo, Keryl Lackey, Stephanie BE Schmorrow, DD Fidopiastis, CM TI Analysis of Multiple Physiological Sensor Data SO FOUNDATIONS OF AUGMENTED COGNITION: DIRECTING THE FUTURE OF ADAPTIVE SYSTEMS SE Lecture Notes in Artificial Intelligence LA English DT Proceedings Paper CT 6th International Conference on Foundations of Augmented Cognition (FAC) Held as Part of 14th International Conference on Human-Computer Interaction (HCI) CY JUL 09-14, 2011 CL Orlando, FL DE EEG; ECG; Eye Tracking; Statistical Analyses; Emotion AB Physiological measures offer many benefits to psychological research including objective, non-intrusive assessment of affective and cognitive states. However, this utility is limited by analysis techniques available for testing data recorded by multiple physiological sensors. The present paper presents one set of data that was attained from a repeated measures design with a nominal independent variable for analysis. Specifically, the International Affective Picture System (IAPS; Lang, Bradley, & Cuthbert, 2008), a series of images known to convey seven different emotions, was presented to participants while measures of their neurological activity (Electroencephalogram; EEG), heart rate (Electrocardiogram; ECG), skin conductance (Galvanic Skin Respond; GSR), and pupillary response were taken. Subsequently, a discussion of statistics available for analyzing responses attained from the various sensors is presented. Such statistics include correlation, ANOVA, MANOVA, regression, and discriminant function analysis. The details on design limitations are addressed and recommendations are given for employing each statistical option. C1 [Reinerman-Jones, Lauren; Taylor, Grant; Lackey, Stephanie] Univ Cent Florida, Inst Simulat & Training, 3100 Technol Pkwy, Orlando, FL 32826 USA. [Cosenzo, Keryl] Army Res Lab, Aberdeen Proving Ground, Adelphi, MD 20783 USA. RP Reinerman-Jones, L (reprint author), Univ Cent Florida, Inst Simulat & Training, 3100 Technol Pkwy, Orlando, FL 32826 USA. EM lreinerm@ist.ucf.edu FU Alion IDIQ Subcontract [8005.00X.10]; Army Research Laboratory [DAAD1901-C-0065, 119, STM1196782] FX This work was funded by Alion IDIQ Subcontract Agreement No. 8005.00X.10 in support of Army Research Laboratory Prime Contract DAAD1901-C-0065, Delivery Order # 119 along with Alion P. O. # STM1196782. NR 2 TC 0 Z9 0 U1 0 U2 4 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0302-9743 BN 978-3-642-21851-4 J9 LECT NOTES ARTIF INT PY 2011 VL 6780 BP 112 EP 119 PG 8 WC Computer Science, Artificial Intelligence SC Computer Science GA BDB81 UT WOS:000312501400014 ER PT S AU Barber, D Hudson, I AF Barber, Daniel Hudson, Irwin BE Schmorrow, DD Fidopiastis, CM TI Distributed Logging and Synchronization of Physiological and Performance Measures to Support Adaptive Automation Strategies SO FOUNDATIONS OF AUGMENTED COGNITION: DIRECTING THE FUTURE OF ADAPTIVE SYSTEMS SE Lecture Notes in Artificial Intelligence LA English DT Proceedings Paper CT 6th International Conference on Foundations of Augmented Cognition (FAC) Held as Part of 14th International Conference on Human-Computer Interaction (HCI) CY JUL 09-14, 2011 CL Orlando, FL DE Adaptive Automation; Closed-Loop Training System; Data Synchronization AB As advances in physiological sensors make them more minimally intrusive and easier to use, there is a clear desire by researchers in the fields of Augmented Cognition and Neuroergonomics to incorporate them as much as possible. To best support use of multiple measures, the data from each sensor must be accurately synchronized across all devices and tied to performance and environment events. However, each sensor provides different sampling frequencies, local timing information, and timing accuracy making data synchronization in logs or real time systems difficult. In this paper, a modular architecture is presented to address the issue of how to synchronize data to support analysis of physiological and performance measures. Specific design requirements are presented to ensure the ability to accurately measure raw sensor data and compute metrics in a distributed computing environment to support adaptive automation strategies in a research environment. Finally, an example system is described which combines multiple minimally invasive physiological sensors. C1 [Barber, Daniel] Univ Cent Florida, Inst Simulat & Training Appl Cognit, 3100 Technol Pkwy, Orlando, FL 32826 USA. [Hudson, Irwin] US Army Res Lab, SFC Paul Ray Smith Simulat Training Technol Ctr S, Orlando, FL USA. RP Barber, D (reprint author), Univ Cent Florida, Inst Simulat & Training Appl Cognit, 3100 Technol Pkwy, Orlando, FL 32826 USA. EM dbarber@ist.ucf.edu FU US Army RDECOM [W91CRB08D0015] FX This work was supported by the US Army RDECOM ( W91CRB08D0015). The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of RDECOM or the US Government. The US Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. NR 8 TC 0 Z9 0 U1 0 U2 2 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0302-9743 BN 978-3-642-21851-4 J9 LECT NOTES ARTIF INT PY 2011 VL 6780 BP 559 EP 566 PG 8 WC Computer Science, Artificial Intelligence SC Computer Science GA BDB81 UT WOS:000312501400064 ER PT S AU Barber, D Reinerman-Jones, L Lackey, S Hudson, I AF Barber, Daniel Reinerman-Jones, Lauren Lackey, Stephanie Hudson, Irwin BE Schmorrow, DD Fidopiastis, CM TI Augmenting Robot Behaviors Using Physiological Measures SO FOUNDATIONS OF AUGMENTED COGNITION: DIRECTING THE FUTURE OF ADAPTIVE SYSTEMS SE Lecture Notes in Artificial Intelligence LA English DT Proceedings Paper CT 6th International Conference on Foundations of Augmented Cognition (FAC) Held as Part of 14th International Conference on Human-Computer Interaction (HCI) CY JUL 09-14, 2011 CL Orlando, FL DE Multi-Modal Communion; Implicit Communication; Human Robot Interaction; Physiological Measures for State Measurement ID ENGAGEMENT AB In recent years, advancements in Unmanned Systems have allowed Human Robot Interaction (HRI) to transition from direct remote control to autonomous systems capable of self-navigation. However, these new technologies do not yet support true mixed-initiative solider-robot teaming where soldiers work with another agent as if it were another human being. In order to achieve this goal, researchers must explore new types of multi-modal and natural communication strategies and methods to provide robots improved understanding of their human counterparts' thought process. Physiological sensors are continuously becoming more portable and affordable leading to the possibility of providing new insight of team member state to a robot team member. However, steps need to be taken to improve how affective and cognitive states are measured and how these new metrics can be used to augment the decision making process for a robot team member. This paper describes current state of the art and next steps needed for accurate profile creation for improved human robot team performance. C1 [Barber, Daniel; Reinerman-Jones, Lauren; Lackey, Stephanie] Univ Cent Florida, Inst Simulat & Training Appl Cognit, 3100 Technol Pkwy, Orlando, FL 32826 USA. [Hudson, Irwin] US Army Res Lab, SFC Paul Ray Smith Simulat Training Technol Ctr S, Orlando, FL USA. RP Barber, D (reprint author), Univ Cent Florida, Inst Simulat & Training Appl Cognit, 3100 Technol Pkwy, Orlando, FL 32826 USA. FU US Army RDECOM [W91CRB08D0015] FX This work was supported by the US Army RDECOM ( W91CRB08D0015). The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of RDECOM or the US Government. The US Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. NR 21 TC 1 Z9 1 U1 1 U2 2 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0302-9743 BN 978-3-642-21851-4 J9 LECT NOTES ARTIF INT PY 2011 VL 6780 BP 567 EP 572 PG 6 WC Computer Science, Artificial Intelligence SC Computer Science GA BDB81 UT WOS:000312501400065 ER PT S AU Luqi Jacoby, G AF Luqi Jacoby, Grant BE Calinescu, R Jackson, E TI Testing Adaptive Probabilistic Software Components in Cyber Systems SO FOUNDATIONS OF COMPUTER SOFTWARE: MODELING, DEVELOPMENT, AND VERIFICATION OF ADAPTIVE SYSTEMS SE Lecture Notes in Computer Science LA English DT Proceedings Paper CT 16th Monterey Workshop CY MAR 31-APR 02, 2010 CL Microsoft Res Redmond, Redmond, WA SP NSF, ONR, AFOSR, ARO, DARPA, Microsoft HO Microsoft Res Redmond C1 [Luqi] US Navy, Postgrad Sch, Monterey, CA 93943 USA. [Jacoby, Grant] US Mil Acad, West Point, NY 10996 USA. RP Luqi (reprint author), US Navy, Postgrad Sch, Monterey, CA 93943 USA. NR 35 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0302-9743 BN 978-3-642-21292-5 J9 LECT NOTES COMPUT SC PY 2011 VL 6662 BP 228 EP 238 PG 11 WC Computer Science, Software Engineering; Computer Science, Theory & Methods SC Computer Science GA BG7ZE UT WOS:000392099900013 ER PT J AU Yannarell, AC Busby, RR Denight, ML Gebhart, DL Taylor, SJ AF Yannarell, Anthony C. Busby, Ryan R. Denight, Michael L. Gebhart, Dick L. Taylor, Steven J. TI Soil bacteria and fungi respond on different spatial scales to invasion by the legume Lespedeza cuneata SO FRONTIERS IN MICROBIOLOGY LA English DT Article DE invasive species; Lespedeza cuneata; soil microbial community; spatial scaling; bacteria; fungi; ultivariate data analysis AB The spatial scale on which microbial communities respond to plant invasions may provide important clues as to the nature of potential invader microbe interactions. Lespedeza cuneata (Dum. Cours.) G. Don is an invasive legume that may benefit from associations with mycorrhizal fungi; however, it has also been suggested that the plant is allelopathic and may alter the soil chemistry of invaded sites through secondary metabolites in its root exudates or litter. Thus, L. cuneata invasion may interact with soil microorganisms on a variety of scales. We investigated L. cuneata-related changes to soil bacterial and fungal communities at two spatial scales using multiple sites from across its invaded N. American range. Using whole-community DNA fingerprinting, we characterized microbial community variation at the scale of entire invaded sites and at the scale of individual plants. Based on permutational multivariate analysis of variance, soil bacterial communities in heavily invaded sites were significantly different from those of uninvaded sites, but bacteria did not show any evidence of responding at very local scales around individual plants. In contrast, soil fungi did not change significantly at the scale of entire sites, but there were significant differences between fungal communities of native versus exotic plants within particular sites. The differential scaling of bacterial and fungal responses indicates that L. cuneata interacts differently with soil bacteria and soil fungi, and these microorganisms may play very different roles in the invasion process of this plant. C1 [Yannarell, Anthony C.] Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61081 USA. [Busby, Ryan R.; Denight, Michael L.; Gebhart, Dick L.] US Army Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL USA. [Taylor, Steven J.] Univ Illinois, Illinois Nat Hist Survey, Champaign, IL USA. RP Yannarell, AC (reprint author), Univ Illinois, Dept Nat Resources & Environm Sci, 1102 S Goodwin Ave MC 047, Urbana, IL 61081 USA. EM acyann@illinois.edu OI Taylor, Steven/0000-0002-3020-5205 FU U.S. Army Engineer Research and Development Center [W9132T-09-2-0011]; Cooperative State Research, Education and Extension Service, U.S. Department of Agriculture [ILLU-875-317] FX The authors gratefully acknowledge B. Widener (Ft. Benning), A. Leonard (Ft. Campbell), J. Proffitt (Ft. Leonard Wood), J. Barbur (Ft. Riley), and S. Osborn (Ft. Stewart) for their assistance with fieldwork. J. Dawson and R. Mackie assisted with advice at the design stage of this work, and Y.-R. Chang and H. M. Tin assisted with sample processing. A. Kent, D. Keymer, A. Peralta, and S. Paver provided valuable feedback during the preparation of this manuscript. This work was supported by grant Army W9132T-09-2-0011 from the U.S. Army Engineer Research and Development Center and also by the Cooperative State Research, Education and Extension Service, U.S. Department of Agriculture, under project number ILLU-875-317. NR 70 TC 15 Z9 15 U1 5 U2 43 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1664-302X J9 FRONT MICROBIOL JI Front. Microbiol. PY 2011 VL 2 AR 127 DI 10.3389/fmicb.2011.00127 PG 12 WC Microbiology SC Microbiology GA V31DE UT WOS:000208863500137 PM 21687434 ER PT J AU Kovesdi, E Gyorgy, AB Kwon, SKC Wingo, DL Kamnaksh, A Long, JB Kasper, CE Agoston, DV AF Kovesdi, Erzsebet Gyorgy, Andrea B. Kwon, Sook-Kyung C. Wingo, Daniel L. Kamnaksh, Alaa Long, Joseph B. Kasper, Christine E. Agoston, Denes V. TI The effect of enriched environment on the outcome of traumatic brain injury; a behavioral, proteomics, and histological study SO FRONTIERS IN NEUROSCIENCE LA English DT Article DE neurogenesis; enriched environment; traumatic brain injury; memory; anxiety; hippocampus; histology; proteomics AB De novo hippocampal neurogenesis contributes to functional recovery following traumatic brain injury (TBI). Enriched environment (EEN) can improve the outcome of TBI by positively affecting neurogenesis. Blast induced traumatic brain injury (bTBI) characterized by memory impairment and increased anxiety levels, is a leading cause of chronic disability among soldiers. Using a rodent model of bTBI we asked: (a) whether long-term exposure to EEN after injury can ameliorate behavioral abnormalities and (b) what the effects of EEN are at the molecular and cellular levels and on de novo neurogenesis. We found that housing injured animals in EEN resulted in significantly improved spatial memory while animals in normal housing (NH) showed persistent memory impairment. VEGF and Tau protein but not Interleukin-6 (IL-6) levels were normalized in the dorsal hippocampus (DHC) of EEN rats while all three markers remained elevated in NH rats. Interestingly, after peaking at 6 weeks post-injury, anxiety returned to normal levels at 2 months independent of housing conditions. Housing animals in EEN had no significant effect on VEGF and Tau protein levels in the ventral hippocampus (VHC) and the amygdala (AD). We also found that EEN reduced IL-6 and IFN gamma levels in the VHC; these markers remained elevated following NH. We observed an increase in GFAP and DCX immunoreactivities in the VHC of NH animals at 2 months post-injury. Conversely, injured animals housed in EEN showed no increase in GFAP or DCX immunoreactivity in their VHC. In summary, long-term exposure of injured animals to EEN appears to play a positive role in the restoration of memory functions but not on anxiety, which returned to normal levels after a significant period of time. Cellular and molecular changes in response to EEN appear to be a part of neurogenesis-independent as well as dependent recovery processes triggered by bTBI. C1 [Kovesdi, Erzsebet; Kasper, Christine E.] US Dept Vet Affairs, Vet Affairs Cent Off, Washington, DC USA. [Gyorgy, Andrea B.; Kwon, Sook-Kyung C.; Wingo, Daniel L.; Kamnaksh, Alaa; Agoston, Denes V.] Uniformed Serv Univ Hlth Sci, Sch Med, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA. [Long, Joseph B.] Walter Reed Army Inst Res, Div Mil Casualty Res, Silver Spring, MD USA. RP Agoston, DV (reprint author), Uniformed Serv Univ Hlth Sci, Sch Med, Dept Anat Physiol & Genet, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM vagoston@usuhs.edu FU VA grant [B5044R] FX We thank the Neurotrauma Team (WRAIR) for their technical help during the blast exposures; Dr. David Jacobowitz (USU) for his help in brain micropunch dissections; Ms. Cara Olsen (USU) for her help in statistical analysis; Drs. Neil Grunberg and John Wu (USU) for their input in designing and interpreting the behavioral experiments. The work was supported by VA grant # B5044R. NR 125 TC 44 Z9 44 U1 3 U2 7 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1662-453X J9 FRONT NEUROSCI-SWITZ JI Front. Neurosci. PY 2011 VL 5 AR 42 DI 10.3389/fnins.2011.00042 PG 12 WC Neurosciences SC Neurosciences & Neurology GA V36GI UT WOS:000209200600038 PM 21503146 ER PT J AU Bernhardt, V Hotchkiss, MT Garcia-Reyero, N Escalon, BL Denslow, N Davenport, PW AF Bernhardt, Vipa Hotchkiss, Mark T. Garcia-Reyero, Natalia Escalon, B. Lynn Denslow, Nancy Davenport, Paul W. TI Tracheal Occlusion Conditioning in Conscious Rats Modulates Gene Expression Profile of Medial Thalamus SO FRONTIERS IN PHYSIOLOGY LA English DT Article DE respiratory load; control of breathing; load compensation; stress AB The thalamus may be the critical brain area involved in sensory gating and the relay of respiratory mechanical information to the cerebral cortex for the conscious awareness of breathing. We hypothesized that respiratory mechanical stimuli in the form of tracheal occlusions would modulate the gene expression profile of the thalamus. Specifically, it was reasoned that conditioning to the respiratory loading would induce a state change in the medial thalamus consistent with a change in sensory gating and the activation of molecular pathways associated with learning and memory. In addition, respiratory loading is stressful and thus should elicit changes in gene expressions related to stress, anxiety, and depression. Rats were instrumented with inflatable tracheal cuffs. Following surgical recovery, they underwent 10 days (5 days/week) of transient tracheal occlusion conditioning. On day 10, the animals were sacrificed and the brains removed. The medial thalamus was dissected and microarray analysis of gene expression performed. Tracheal obstruction conditioning modulated a total of 661 genes (p < 0.05, log(2) fold change >= 0.58), 250 genes were down-regulated and 411 up-regulated. There was a significant down-regulation of GAD1, GAD2 and HTR1A, HTR2A genes. CCK, PRKCG, mGluR4, and KCJN9 genes were significantly up-regulated. Some of these genes have been associated with anxiety and depression, while others have been shown to play a role in switching between tonic and burst firing modes in the thalamus and thus may be involved in gating of the respiratory stimuli. Furthermore, gene ontology and pathway analysis showed a significant modulation of learning and memory pathways. These results support the hypothesis that the medial thalamus is involved in the respiratory sensory neural pathway due to the state change of its gene expression profile following repeated tracheal occlusions. C1 [Bernhardt, Vipa; Hotchkiss, Mark T.; Denslow, Nancy; Davenport, Paul W.] Univ Florida, Dept Physiol Sci, Gainesville, FL 32610 USA. [Garcia-Reyero, Natalia] Jackson State Univ, Dept Chem, Jackson, MS 39217 USA. [Garcia-Reyero, Natalia; Denslow, Nancy] Univ Florida, Ctr Environm & Human Toxicol, Gainesville, FL 32611 USA. [Escalon, B. Lynn] US Army Engn Res & Dev Ctr, Vicksburg, MS USA. RP Davenport, PW (reprint author), Univ Florida, Dept Physiol Sci, Gainesville, FL 32610 USA. EM pdavenpo@ufl.edu FU US Army Environmental Quality Research Program FX Support for B. Lynn Escalon was provided by the US Army Environmental Quality Research Program. NR 63 TC 6 Z9 6 U1 1 U2 1 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1664-042X J9 FRONT PHYSIOL JI Front. Physiol. PY 2011 VL 2 AR 24 DI 10.3389/fphys.2011.00024 PG 10 WC Physiology SC Physiology GA V35UD UT WOS:000209172600024 PM 21660287 ER PT J AU Hinojosa-Laborde, C Rickards, CA Ryan, KL Convertino, VA AF Hinojosa-Laborde, Carmen Rickards, Caroline A. Ryan, Kathy L. Convertino, Victor A. TI Heart rate variability during simulated hemorrhage with lower body negative pressure in high and low tolerant subjects SO FRONTIERS IN PHYSIOLOGY LA English DT Article DE lower body negative pressure; hypovolemia; hemorrhage; heart rate variability; heart period variability AB Heart rate variability (HRV) decreases during hemorrhage, and has been proposed as a new vital sign to assess cardiovascular stability in trauma patients. The purpose of this study was to determine if any of the HRV metrics could accurately distinguish between individuals with different tolerance to simulated hemorrhage. Specifically, we hypothesized that (1) HRV would be similar in low tolerant (LT) and high tolerant (HT) subjects at presyncope when both groups are on the verge of hemodynamic collapse; and (2) H RV could distinguish LT subjects at presyncope from hemodynamically stable HT subjects (i.e., at a submaximal level of hypovolemia). Lower body negative pressure (LBNP) was used as a model of hemorrhage in healthy human subjects, eliciting central hypovolemia to the point of presyncopal symptoms (onset of hemodynamic collapse). Subjects were classified as LT if presyncopal symptoms occurred during the 15 to 60 mmHg levels of LBNP and HT if symptoms occurred after LBNP of 60 mmHg. A total of 20 HRV metrics were derived from R R interval measurements at the time of presyncope, and at one level prior to presyncope (submax) in LT and HT groups. Only four HRV metrics (Long-range Detrended Fluctuation Analysis, Forbidden Words, Poincare Plot Descriptor Ratio, and Fractal Dimensions by Curve Length) supported both hypotheses.These four HRV metrics were evaluated further for their ability to identify individual LT subjects at presyncope when compared to HT subjects at submax. Variability in individual LT and HT responses was so high that LT responses overlapped with HT responses by 85-97%. The sensitivity of these HRV metrics to distinguish between individual LT from HT subjects was 6-33%, and positive predictive values were 40-73%. These results indicate that while a small number of HRV metrics can accurately distinguish between LT and HT subjects using group mean data, individual HRV values are poor indicators of tolerance to hypovolemia. C1 [Hinojosa-Laborde, Carmen; Ryan, Kathy L.; Convertino, Victor A.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Rickards, Caroline A.] Univ Texas San Antonio, Dept Hlth & Kinesiol, San Antonio, TX USA. RP Hinojosa-Laborde, C (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM c.hinojosalaborde@us.army.mil FU United States Army Medical Research and Materiel Command FX We thank the research volunteers for their cheerful participation, Dr, James Aden for his assistance in statistical analysis, and Mr. Gary Muniz for his excellent laboratory assistance. This study was funded by the United States Army Medical Research and Materiel Command. NR 45 TC 12 Z9 12 U1 0 U2 0 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1664-042X J9 FRONT PHYSIOL JI Front. Physiol. PY 2011 VL 2 AR 85 DI 10.3389/fphys.2011.00085 PG 9 WC Physiology SC Physiology GA V35UD UT WOS:000209172600085 PM 22125539 ER PT J AU West, BJ AF West, Bruce J. TI Overview 2010 of ARL program on network science for human decision making SO FRONTIERS IN PHYSIOLOGY LA English DT Review DE complex networks; principle complexity management; decision making model AB The Army Research Laboratory program on the Network Science of Human Decision Making brings together researchers from a variety of disciplines to work on a complex research problem that defies confinement within any single discipline. Consequently, new and rewarding solutions have been obtained for a problem of importance to society and the Army, that being, the human dimension of complex networks. This program investigates the basic research foundation of a science of networks supporting the linkage between the cognitive and social domains as they relate to human decision making. The research strategy extends recent methods of non-equilibrium statistical physics to non-stationary, renewal stochastic processes characteristic of the interactions among nodes in complex networks. The theoretical analyses of complex networks, although mathematically rigorous, often elude analytic solutions and require simulation and computation to analyze the underlying dynamic process. The information transfer between two complex networks is calculated using the principle of complexity management as well as direct numerical calculation of the decision making model developed within the project. C1 US Army, Res Off, Informat Sci Directorate, Durham, NC 27709 USA. RP West, BJ (reprint author), US Army, Res Off, Informat Sci Directorate, Durham, NC 27709 USA. EM bruce.j.west@att.net NR 29 TC 1 Z9 1 U1 0 U2 1 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1664-042X J9 FRONT PHYSIOL JI Front. Physiol. PY 2011 VL 2 AR 76 DI 10.3389/fphys.2011.00076 PG 6 WC Physiology SC Physiology GA V35UD UT WOS:000209172600076 PM 22110441 ER PT J AU Gagnon, SA Brunye, TT Robin, C Mahoney, CR Taylor, HA AF Gagnon, Stephanie A. Brunye, Tad T. Robin, Cynthia Mahoney, Caroline R. Taylor, Holly A. TI High and mighty: implicit associations between space and social status SO FRONTIERS IN PSYCHOLOGY LA English DT Article DE spatial cognition; social status; north-south bias; metaphor; embodiment; IAT AB Figurative language and our perceptuo-motor experiences frequently associate social status with physical space. In three experiments we examine the source and extent of these associations by testing whether people implicitly associate abstract social status indicators with concrete representations of spatial topography (level versus mountainous land) and relatively abstract representations of cardinal direction (south and north). Experiment 1 demonstrates speeded performance during an implicit association test (Greenwald et al., 1998) when average social status is paired with level topography and high status with mountainous topography. Experiments 2 and 3 demonstrate a similar effect but with relatively abstract representations of cardinal direction (south and north), with speeded performance when average and powerful social status are paired with south and north coordinate space, respectively. Abstract concepts of social status are perceived and understood in an inherently spatial world, resulting in powerful associations between abstract social concepts and concrete and abstract notions of physical axes. These associations may prove influential in guiding daily judgments and actions. C1 [Gagnon, Stephanie A.; Brunye, Tad T.; Mahoney, Caroline R.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. [Gagnon, Stephanie A.; Brunye, Tad T.; Mahoney, Caroline R.; Taylor, Holly A.] US Army, Natick Soldier RDE Ctr, Natick, MA 01760 USA. [Robin, Cynthia] Northwestern Univ, Dept Anthropol, Evanston, IL 60208 USA. RP Brunye, TT (reprint author), US Army, Natick Soldier RDE Ctr, Bldg 4,Room 126,15 Kansas St, Natick, MA 01760 USA. EM tbruny01@tufts.edu NR 56 TC 4 Z9 4 U1 3 U2 8 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1664-1078 J9 FRONT PSYCHOL JI Front. Psychol. PY 2011 VL 2 AR 259 DI 10.3389/fpsyg.2011.00259 PG 10 WC Psychology, Multidisciplinary SC Psychology GA V31DH UT WOS:000208863800074 PM 22013428 ER PT J AU Williams, CD Stengel, J Asike, MI Torres, DM Shaw, J Contreras, M Landt, CL Harrison, SA AF Williams, Christopher D. Stengel, Joel Asike, Michael I. Torres, Dawn M. Shaw, Janet Contreras, Maricela Landt, Cristy L. Harrison, Stephen A. TI Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study SO GASTROENTEROLOGY LA English DT Article DE NAFLD; NASH: Prevalence; Ultrasound: Liver Biopsy; Fatty Liver Disease; Hepatic Steatosis ID INSULIN-RESISTANCE; HEPATIC STEATOSIS; DIETARY HABITS; UNITED-STATES; FOLLOW-UP; DONORS; TRANSPLANTATION; SURVIVAL; OBESITY; COHORT AB BACKGROUND & AIMS: Prevalence of nonalcoholic fatty liver disease (NAFLD) has not been well established. The purpose of this study was to prospectively define the prevalence of both NAFLD and nonalcoholic steatohepatitis (NASH). METHODS: Outpatients 18 to 70 years old were recruited from Brooke Army Medical Center. All patients completed a baseline questionnaire and ultrasound. If fatty liver was identified, then laboratory data and a liver biopsy were obtained. RESULTS: Four hundred patients were enrolled. Three hundred and twenty-eight patients completed the questionnaire and ultrasound. Mean age (range, 28-70 years) was 54.6 years (7.35); 62.5% Caucasian, 22% Hispanic, and 11.3% African American; 50.9% female; mean body mass index (BMI) (calculated as kg/m(2)) was 29.8 (5.64); and diabetes and hypertension prevalence 16.5% and 49.7%, respectively. Prevalence of NAFLD was 46%. NASH was confirmed in 40 patients (12.2% of total cohort, 29.9% of ultrasound positive patients). Hispanics had the highest prevalence of NAFLD (58.3%), then Caucasians (44.4%) and African Americans (35.1%). NAFLD patients were more likely to be male (58.9%), older (P = .004), hypertensive (P < .00005), and diabetic (P < .00005). They had a higher BMI (P < .0005), ate fast food more often (P = .049), and exercised less (P = 0.02) than their non-NAFLD counterparts. Hispanics had a higher prevalence of NASH compared with Caucasians (19.4% vs 9.8%; P = .03). Alanine aminotransferase, aspartate aminotransferase, BMI, insulin, Quantitative Insulin-Sensitivity Check Index, and cytokeratin-18 correlated with NASH. Among the 54 diabetic patients, NAFLD was found in 74% and NASH in 22.2%. CONCLUSION: Prevalence of NAFLD and NASH is higher than estimated previously. Hispanics and patients with diabetes are at greatest risk for both NAFLD and NASH. C1 [Harrison, Stephen A.] Brooke Army Med Ctr, Dept Med, Div Gastroenterol & Hepatol, Gastroenterol & Hepatol Serv, Ft Sam Houston, TX 78234 USA. [Shaw, Janet] Dept Pathol, Ft Sam Houston, TX USA. [Contreras, Maricela] Dept Radiol, Ft Sam Houston, TX USA. [Landt, Cristy L.] Dept Clin Invest, Ft Sam Houston, TX USA. [Shaw, Janet] Wilford Hall USAF Med Ctr, Ft Sam Houston, TX USA. RP Harrison, SA (reprint author), Brooke Army Med Ctr, Dept Med, Div Gastroenterol & Hepatol, Gastroenterol & Hepatol Serv, Ft Sam Houston, TX 78234 USA. EM Stephen.harrison@amedd.army.mil NR 28 TC 584 Z9 610 U1 7 U2 44 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD JAN PY 2011 VL 140 IS 1 BP 124 EP 131 DI 10.1053/j.gastro.2010.09.038 PG 8 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 697HF UT WOS:000285503200028 PM 20858492 ER PT J AU Stouch, DW Zeidman, E Richards, M McGraw, KD Callahan, W AF Stouch, Daniel W. Zeidman, Ernest Richards, Marc McGraw, Kirk D. Callahan, William BE Krasnogor, N TI Coevolving Collection Plans for UAS Constellations SO GECCO-2011: PROCEEDINGS OF THE 13TH ANNUAL GENETIC AND EVOLUTIONARY COMPUTATION CONFERENCE LA English DT Proceedings Paper CT 13th Annual Genetic and Evolutionary Computation Conference (GECCO) CY JUL 12-16, 2011 CL Dublin, IRELAND SP Assoc Comp Machinery, Special Interest Grp Genet & Evolutionary Computat (ACM SIGEVO) DE Evolutionary algorithms; multi-objective evolutionary algorithms; air operations; mission planning; unmanned systems AB Our SPARTEN (Spatially Produced Airspace Routes from Tactical Evolved Networks) tool generates coordinated mission plans for constellations of unmanned aerial vehicles by allowing the mission planner to specify the importance of each objective for each mission. Using an evolutionary algorithm-based, multi-objective optimization technique, we consider factors such as area of analysis coverage, restricted operating zones, maximum ground control station range, adverse weather effects, military terrain value, airspace collision avoidance, path linearity, named area of analysis emphasis, and sensor performance. By employing novel visualizations using geographic information systems to represent their effectiveness, we help the user "look under the hood" of the algorithms and understand the viability and effectiveness of the mission plans to identify coverage gaps and other inefficiencies. In this paper, we apply multi-objective evolutionary algorithms to the air mission planning domain, with a focus on the visualization components. C1 [Stouch, Daniel W.; Zeidman, Ernest; Richards, Marc; Callahan, William] Charles River Analyt, 625 Mt Auburn St, Cambridge, MA 02138 USA. [McGraw, Kirk D.] US Army, ERDC, CERL, Cambridge, MA 02138 USA. RP Stouch, DW (reprint author), Charles River Analyt, 625 Mt Auburn St, Cambridge, MA 02138 USA. EM dws@cra.com; ewz@cra.com; mdr@cra.com; bjc@cra.com FU Government [W9132T-06-C-0040, W9132T-09-C-0028]; U.S. Army Engineer Research and Development Center (ERDC); Construction Engineering Research Laboratory (CERL); Army Geospatial Center (AGC) FX The work presented here has been supported by Government Contract Numbers W9132T-06-C-0040 and W9132T-09-C-0028. The authors would like to thank U.S. Army Engineer Research and Development Center (ERDC) Construction Engineering Research Laboratory (CERL) and Army Geospatial Center (AGC) for their assistance and vision under the Battlespace Terrain Reasoning and Awareness (BTRA) and Geospatially-Enabled Multimodal Situational Awareness (GEMS) programs. NR 9 TC 1 Z9 1 U1 0 U2 1 PU ASSOC COMPUTING MACHINERY PI NEW YORK PA 1515 BROADWAY, NEW YORK, NY 10036-9998 USA BN 978-1-4503-0557-0 PY 2011 BP 1691 EP 1698 PG 8 WC Computer Science, Artificial Intelligence; Computer Science, Software Engineering; Mathematics, Applied SC Computer Science; Mathematics GA BGB06 UT WOS:000322137100213 ER PT J AU Everitt, JH Yang, C Summy, KR Owens, CS Glomski, LM Smart, RM AF Everitt, J. H. Yang, C. Summy, K. R. Owens, C. S. Glomski, L. M. Smart, R. M. TI Using in situ hyperspectral reflectance data to distinguish nine aquatic plant species SO GEOCARTO INTERNATIONAL LA English DT Article DE hyperspectral reflectance; spectral signature; multiple comparison range test; stepwise discriminant analysis; Eichhornia crassipes; Nelumbo lutea; Nuphar lutea; Nymphaea mexicana; Nymphaea odorata; Pistia stratiotes; Potamogeton nodusus; Salvinia molesta; Spirodela polyrrhiza AB In situ hyperspectral reflectance data were studied at 50 bands (10 nm bandwidth) over the 400-900 nm spectral range to determine their potential for distinguishing among nine aquatic plant species: American lotus [Nelumbo lutea (Willd.) Pers.], American pondweed (Potamogeton nodusus Poir.), giant duckweed [Spirodela polyrrhiza (L.) Schleid.], Mexican waterlily (Nymphaea mexicana Zucc.), white waterlily (Nymphaea odorata Aiton), spatterdock [Nuphar lutea (L.) Sm.], giant salvinia (Salvinia molesta Mitchell), waterhyacinth [Eichhornia crassipes (Mart.) Solms] and waterlettuce (Pistia stratiotes L.). The species were studied on three dates: 30 May, 1 July and 3 August 2009. All nine species were studied in July and August, while only eight species were studied in May; giant duckweed was not studied in May due to insufficient availability. Two procedures were used to determine the optimum bands for discriminating among species: multiple comparison range tests and stepwise discriminant analysis. Multiple comparison range tests results for May showed that most separations among species occurred at bands 795-865 nm in the near-infrared (NIR) spectral region where up to six species could be distinguished. For July, few species could be distinguished among the 50 bands; most separations occurred at the 715 nm red-NIR edge band where four species could be differentiated. The optimum bands in August occurred in the green (525-595 nm), red (605-635 nm) and red-NIR edge (695-705 nm) spectral regions where up to six species could be distinguished. Stepwise discriminant analysis identified 11 bands in the blue, green, red-NIR edge and NIR spectral regions to be significant to discriminate among the eight species in May. For July and August, stepwise discriminant analysis identified 15 bands and 13 bands, respectively, from the blue to NIR regions to be significant for discriminating among the nine species. C1 [Everitt, J. H.; Yang, C.] ARS, USDA, Weslaco, TX 78596 USA. [Summy, K. R.] Univ Texas Pan Amer, Dept Biol, Edinburg, TX 78539 USA. [Owens, C. S.; Glomski, L. M.; Smart, R. M.] USA, Lewisville Aquat Ecosyst Res Facil, Engineer Res & Dev Ctr, Lewisville, TX 75057 USA. RP Everitt, JH (reprint author), ARS, USDA, 2413 E Highway 83, Weslaco, TX 78596 USA. EM james.everitt@ars.usda.gov NR 34 TC 1 Z9 1 U1 4 U2 8 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1010-6049 J9 GEOCARTO INT JI Geocarto Int. PY 2011 VL 26 IS 6 BP 459 EP 473 DI 10.1080/10106049.2011.591944 PG 15 WC Environmental Sciences; Geosciences, Multidisciplinary; Remote Sensing; Imaging Science & Photographic Technology SC Environmental Sciences & Ecology; Geology; Remote Sensing; Imaging Science & Photographic Technology GA V27SA UT WOS:000208631700004 ER PT J AU Zinnert, JC Shiflett, SA Vick, JK Young, DR AF Zinnert, Julie C. Shiflett, Sheri A. Vick, Jaclyn K. Young, Donald R. TI Woody vegetative cover dynamics in response to recent climate change on an Atlantic coast barrier island: a remote sensing approach SO GEOCARTO INTERNATIONAL LA English DT Article DE barrier island; climate; Landsat TM; LiDAR; woody expansion AB Considering impacts of predicted increases in sea-level, storms, and alterations in precipitation patterns on geomorphological and associated ecological processes, woody vegetation dynamics may serve as sentinels to climate change on barrier islands. We examined island-scale conversion of land (i.e. sand to grassland to woody cover) while relating the importance of climate variables on rate of woody expansion. Light Detection and Ranging (LiDAR) was used to evaluate potential distribution of woody species based on distance to shoreline and elevation. Using Landsat TM imagery, we monitored changes in island size and vegetation classes (1984-2010). These comparisons revealed conversion of grassland to woody cover (285% increase) was closely linked to air temperature, precipitation and atmospheric [CO2]. LiDAR data indicated that woody species have not expanded completely into the potential range. Our results suggest that woody species are responsive to climate change, thus serving as sentinels on Virginia barrier islands. C1 [Zinnert, Julie C.] USA, Erdc, Fluorescence Spect Lab, Alexandria, VA 22315 USA. [Zinnert, Julie C.; Shiflett, Sheri A.; Vick, Jaclyn K.; Young, Donald R.] Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA. RP Zinnert, JC (reprint author), USA, Erdc, Fluorescence Spect Lab, 7701 Telegraph Rd, Alexandria, VA 22315 USA. EM jczinner@vcu.edu FU National Science Foundation [BSR-8702333-06, DEB-9211772, DEB-9411974, DEB-0080381, DEB-0621014] FX Some data used in this publication were provided by the Virginia Coast Reserve LTER project, which was supported by National Science Foundation grants BSR-8702333-06, DEB-9211772, DEB-9411974, DEB-0080381 and DEB-0621014. The authors thank David Starling and Jared Austin for assistance in data preparation and Jennifer Ciminelli and William Shuart for GIS expertise and guidance. NR 44 TC 14 Z9 14 U1 0 U2 10 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1010-6049 J9 GEOCARTO INT JI Geocarto Int. PY 2011 VL 26 IS 8 SI SI BP 595 EP 612 DI 10.1080/10106049.2011.621031 PG 18 WC Environmental Sciences; Geosciences, Multidisciplinary; Remote Sensing; Imaging Science & Photographic Technology SC Environmental Sciences & Ecology; Geology; Remote Sensing; Imaging Science & Photographic Technology GA V27SC UT WOS:000208631900002 ER PT J AU Han, JJ Yu, MS Houston, N Steinberg, SM Kohn, EC AF Han, Jasmine J. Yu, Minshu Houston, Nicole Steinberg, Seth M. Kohn, Elise C. TI Progranulin is a potential prognostic biomarker in advanced epithelial ovarian cancers SO GYNECOLOGIC ONCOLOGY LA English DT Article DE Progranulin (PGRN); Biomarkers; Progression free survival; Overall survival; Epithelial ovarian cancer ID LEUKOCYTE PROTEASE INHIBITOR; GROWTH-FACTOR; INDUCTION CHEMOTHERAPY; CA-125 LEVELS; IN-VIVO; PRECURSOR; CARCINOMA; CELLS; ACROGRANIN; OVEREXPRESSION AB Objective. There are few validated relapse prediction biomarkers for epithelial ovarian cancer (EOC). We have shown progranulin (PGRN) and secretory leukocyte protease inhibitor (SLPI) are up regulated, overexpressed survival factors in EOC. We hypothesized they would predict presence of occult EOC. Method. PGRN, SLPI, and the known biomarker HE4 were measured in EOC patient plasma samples, prospectively collected every 3 months from initial remission until relapse. Clinical data and CA125 results were incorporated into statistical analyses. Exploratory Kaplan-Meier estimates, dividing markers at median values, evaluated association with progression-free survival (PFS) and overall survival (OS). Area-under-the-curve (AUC) statistics were computed from receiver operating characteristic (ROC) curves to evaluate discrimination ability. A Cox proportional hazards model assessed the association between PFS, OS, and biomarkers, adjusting for clinical prognostic factors. Results. Samples from 23 advanced stage EOC patients were evaluated. PGRN at 3 months was the only biomarker independently associated with PFS (P<0.0001) and OS (P<0.003). When used to predict progression by 18 months, sensitivity and specificity were 93% and 100%, respectively, with AUC = 0.944. The Cox model hazard ratio for PFS, divided at 59 ng/ml by ROC analysis and adjusted for clinical factors, was 23.5 (95% CI: 2.49-220). Combinations with SLPI, HE4, and/or CA125 did not improve the model. Conclusions. We report pilot data indicating a potential independent association of PGRN on EOC patient PFS and OS. A validation study will be required to confirm this finding and to inform whether PGRN warrants evaluation as a potential screening biomarker. Published by Elsevier Inc. C1 [Han, Jasmine J.; Yu, Minshu; Houston, Nicole; Kohn, Elise C.] NCI, Med Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA. [Han, Jasmine J.] NCI, Walter Reed Army Med Ctr, Gynecol Malignancies Lab, Bethesda, MD 20892 USA. [Steinberg, Seth M.] NCI, Biostat & Data Management Sect, Ctr Canc Res, Bethesda, MD 20892 USA. RP Kohn, EC (reprint author), 10 Ctr Dr,MSC1500,Bldg 10,Room B1B51, Bethesda, MD 20892 USA. EM Kohne@mail.nih.gov FU NIH, National Cancer Institute, Center for Cancer Research FX This research was supported by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research. NR 38 TC 16 Z9 19 U1 0 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD JAN PY 2011 VL 120 IS 1 BP 5 EP 10 DI 10.1016/j.ygyno.2010.09.006 PG 6 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 701NO UT WOS:000285824800002 PM 20950846 ER PT S AU Fellowes, DA Wood, MV Hastings, AR Draper, RS Ghosh, A Prache, O Wacyk, I Ali, T Khayrullin, I AF Fellowes, David A. Wood, Michael V. Hastings, Arthur R., Jr. Draper, Russell S. Ghosh, Amalkumar Prache, Olivier Wacyk, Ihor Ali, Tariq Khayrullin, Ilyas BE Marasco, PL Havig, PR TI Active matrix organic light emitting diode (AMOLED) performance and life test results SO HEAD- AND HELMET-MOUNTED DISPLAYS XVI: DESIGN AND APPLICATIONS SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Head- and Helmet-Mounted Displays XVI - Design and Applications CY APR 28, 2011 CL Orlando, FL SP SPIE DE AMOLED; OLED; long-life OLED; lifetime; usable display lifetime; SXGA OLED; display; microdisplay AB The US Army and eMagin Corporation established a Cooperative Research and Development Agreement (CRADA) to characterize the ongoing improvements in the lifetime of OLED displays. This CRADA also called for the evaluation of OLED performance as the need arises, especially when new products are developed or when a previously untested parameter needs to be understood. In 2006, eMagin Corporation developed long-life OLED-XL devices for use in their AMOLED microdisplays for head-worn applications. Through research and development programs from 2007 to 2010 with the US Government, eMagin made additional improvements in OLED life and developed the first SXGA (1280 X 1024 triad pixels) OLED microdisplay. US Army RDECOM CERDEC NVESD conducted life and performance tests on these displays, publishing results at the 2007, 2008, 2009, and 2010 SPIE Defense and Security Symposia(1,2,3,4). Life and performance tests have continued through 2010, and this data will be presented along with a recap of previous data. This should result in a better understanding of the applicability of AMOLEDs in military and commercial head mounted systems: where good fits are made, and where further development might be desirable. C1 [Fellowes, David A.; Wood, Michael V.; Hastings, Arthur R., Jr.; Draper, Russell S.] USA, RDECOM CERDEC Night Vis & Elect Sensors Directora, RDER NVS IM, Ft Belvoir, VA 22060 USA. RP Fellowes, DA (reprint author), USA, RDECOM CERDEC Night Vis & Elect Sensors Directora, RDER NVS IM, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-615-8 J9 PROC SPIE PY 2011 VL 8041 AR 80410A DI 10.1117/12.882714 PG 15 WC Optics; Imaging Science & Photographic Technology SC Optics; Imaging Science & Photographic Technology GA BVO18 UT WOS:000292033000009 ER PT S AU Hastings, AR Draper, RS Wood, MV Fellowes, DA AF Hastings, Arthur R., Jr. Draper, Russell S. Wood, Michael V. Fellowes, David A. BE Marasco, PL Havig, PR TI Spatial noise in microdisplays for near to eye applications SO HEAD- AND HELMET-MOUNTED DISPLAYS XVI: DESIGN AND APPLICATIONS SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Head- and Helmet-Mounted Displays XVI - Design and Applications CY APR 28, 2011 CL Orlando, FL SP SPIE DE Spatial noise; fixed pattern noise; microdisplay; noise equivalent delta gray level; fourier analysis AB Spatial noise in imaging systems has been characterized and its impact on image quality metrics has been addressed primarily with respect to the introduction of this noise at the sensor component. However, sensor fixed pattern noise is not the only source of fixed pattern noise in an imaging system. Display fixed pattern noise cannot be easily mitigated in processing and, therefore, must be addressed. In this paper, a thorough examination of the amount and the effect of display fixed pattern noise is presented. The specific manifestation of display fixed pattern noise is dependent upon the display technology. Utilizing a calibrated camera, US Army RDECOM CERDEC NVESD has developed a microdisplay (mu display) spatial noise data collection capability. Noise and signal power spectra were used to characterize the display signal to noise ratio (SNR) as a function of spatial frequency analogous to the minimum resolvable temperature difference (MRTD) of a thermal sensor. The goal of this study is to establish a measurement technique to characterize mu display limiting performance to assist in proper imaging system specification. C1 [Hastings, Arthur R., Jr.; Draper, Russell S.; Wood, Michael V.; Fellowes, David A.] US Army, RDECOM CERDEC Night Vis & Elect Sensors Directora, RDER NVS IM, Ft Belvoir, VA USA. RP Hastings, AR (reprint author), US Army, RDECOM CERDEC Night Vis & Elect Sensors Directora, RDER NVS IM, 10221 Burbeck Rd, Ft Belvoir, VA USA. NR 3 TC 0 Z9 0 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-615-8 J9 PROC SPIE PY 2011 VL 8041 AR 80410B DI 10.1117/12.888051 PG 10 WC Optics; Imaging Science & Photographic Technology SC Optics; Imaging Science & Photographic Technology GA BVO18 UT WOS:000292033000010 ER PT S AU Hiatt, KL Rash, CE AF Hiatt, Keith L. Rash, Clarence E. BE Marasco, PL Havig, PR TI The Reported Incidence of Man-Machine Interface Issues in Army Aviators Using the Aviator's Night Vision System (ANVIS) in a Combat Theatre SO HEAD- AND HELMET-MOUNTED DISPLAYS XVI: DESIGN AND APPLICATIONS SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Head- and Helmet-Mounted Displays XVI - Design and Applications CY APR 28, 2011 CL Orlando, FL SP SPIE DE Helmet-mounted display; Night Vision Goggles; NVG; ANVIS; ALSE; User Satisfaction; Human Factors; Combat ID NECK MUSCLE-ACTIVITY; BACK-PAIN; HELICOPTER PILOTS; HELMET; SPONDYLOLISTHESIS; AIRCREW; FORCES; STRAIN AB Background: Army Aviators rely on the ANVIS for night operations. Human factors literature notes that the ANVIS man-machine interface results in reports of visual and spinal complaints. This is the first study that has looked at these issues in the much harsher combat environment. Last year, the authors reported on the statistically significant (p<0.01) increased complaints of visual discomfort, degraded visual cues, and incidence of static and dynamic visual illusions in the combat environment [Proc. SPIE, Vol. 7688, 76880G (2010)]. In this paper we present the findings regarding increased spinal complaints and other man-machine interface issues found in the combat environment. Methods: A survey was administered to Aircrew deployed in support of Operation Enduring Freedom (OEF). Results: 82 Aircrew (representing an aggregate of >89,000 flight hours of which >22,000 were with ANVIS) participated. Analysis demonstrated high complaints of almost all levels of back and neck pain. Additionally, the use of body armor and other Aviation Life Support Equipment (ALSE) caused significant ergonomic complaints when used with ANVIS. Conclusions: ANVIS use in a combat environment resulted in higher and different types of reports of spinal symptoms and other man-machine interface issues over what was previously reported. Data from this study may be more operationally relevant than that of the peacetime literature as it is derived from actual combat and not from training flights, and it may have important implications about making combat predictions based on performance in training scenarios. Notably, Aircrew remarked that they could not execute the mission without ANVIS and ALSE and accepted the degraded ergonomic environment. C1 [Hiatt, Keith L.] USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Hiatt, KL (reprint author), USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 36 TC 0 Z9 0 U1 1 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-615-8 J9 PROC SPIE PY 2011 VL 8041 AR 80410K DI 10.1117/12.883288 PG 13 WC Optics; Imaging Science & Photographic Technology SC Optics; Imaging Science & Photographic Technology GA BVO18 UT WOS:000292033000019 ER PT S AU Angov, E Legler, PM Mease, RM AF Angov, Evelina Legler, Patricia M. Mease, Ryan M. BE Evans, TC Xu, MQ TI Adjustment of Codon Usage Frequencies by Codon Harmonization Improves Protein Expression and Folding SO HETEROLOGOUS GENE EXPRESSION IN E COLI: METHODS AND PROTOCOLS SE Methods in Molecular Biology LA English DT Article; Book Chapter DE Codon harmonization; codon usage; codon optimization; expression; solubility; protein translation; protein structure; protein folding; circular dichroism ID ESCHERICHIA-COLI; PLASMODIUM-FALCIPARUM; CIRCULAR-DICHROISM; POLYPEPTIDE-CHAINS; MESSENGER-RNA; TRANSLATION; ABUNDANCE; TUNNEL; GENES AB Over the past two decades, prokaryotic expression systems have been widely exploited for the bioproduction of many therapeutic proteins. Much of the success can be attributed to the implementation of basic principles of prokaryotic protein translation and protein folding to the problems of heterologous expression (e.g. codon usage substitutions, tRNA isoacceptor co-expression, chaperone co-expression); however, expression in a heterologous host still remains an empirical process. To improve heterologous protein expression further we have developed an algorithm termed "codon harmonization" that best approximates codon usage frequencies from the native host and adjusts these for use in the heterologous system. The success of this methodology may be due to improved protein folding during translation. Although so far exclusively applied to Escherichia coli, codon harmonization may provide a general strategy for improving the expression of soluble, functional proteins during heterologous host expression. C1 [Angov, Evelina; Mease, Ryan M.] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. [Legler, Patricia M.] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD USA. RP Angov, E (reprint author), Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. NR 29 TC 18 Z9 19 U1 0 U2 10 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA SN 1064-3745 BN 978-1-61737-966-6 J9 METHODS MOL BIOL JI Methods Mol. Biol. PY 2011 VL 705 BP 1 EP 13 DI 10.1007/978-1-61737-967-3_1 D2 10.1007/978-1-61737-967-3 PG 13 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Genetics & Heredity GA BSU97 UT WOS:000285851100001 PM 21125377 ER PT B AU Ottinger, MA Dean, K McKernan, M Quinn, MJ AF Ottinger, Mary Ann Dean, Karen McKernan, Moira Quinn, Michael J., Jr. BE Norris, DO Lopez, KH TI Endocrine Disruption of Reproduction in Birds SO HORMONES AND REPRODUCTION OF VERTEBRATES, VOL 4: BIRDS LA English DT Article; Book Chapter ID POLYBROMINATED DIPHENYL ETHERS; COTURNIX-COTURNIX-JAPONICA; KESTRELS FALCO-SPARVERIUS; MALE JAPANESE-QUAIL; POLYCHLORINATED-BIPHENYLS PCBS; SWALLOWS TACHYCINETA-BICOLOR; AROMATASE-IMMUNOREACTIVE CELLS; ARYL-HYDROCARBON RECEPTOR; MEDIAL PREOPTIC NUCLEUS; LAWRENCE-RIVER BASIN AB Endocrine-disrupting chemicals (EDCs), which mimic endogenous hormones, are creating an emerging issue for avian species. These chemicals include pesticides, herbicides, endocrine-active phytochemicals (EAPs), industrial products, and byproducts of technology that have structural and functional properties that enable them to interact with physiological systems, including the reproductive, thyroid, metabolic, and immune axes. Characterizing the effects of these varied EDCs and establishing reliable indices of exposure that relate to potential risk to avian populations is challenging. The complexity of assessing EDC effects in birds is exacerbated by unique aspects of avian biology including sexual differentiation, lifetime reproductive strategies, migration with varied exposure, mechanisms of actions, and diverse lifespans of birds. Further, exposure is often to a mixture of chemicals with differential species sensitivity at various stages of the lifecycle. It is critical to understand the bioavailability of these compounds in the environment. This chapter considers these issues, including probable mechanisms of action, affected species, lifetime sensitivity to exposure, and potential impacts on avian populations. C1 [Ottinger, Mary Ann] Univ Maryland, College Pk, MD 20742 USA. Amer Bird Conservancy, Washington, DC USA. USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD USA. RP Ottinger, MA (reprint author), Univ Maryland, College Pk, MD 20742 USA. NR 195 TC 2 Z9 2 U1 1 U2 6 PU ELSEVIER ACADEMIC PRESS INC PI SAN DIEGO PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA BN 978-0-08-095805-7; 978-0-12-374929-1 PY 2011 BP 239 EP 260 PG 22 WC Ornithology; Reproductive Biology; Zoology SC Zoology; Reproductive Biology GA BEO96 UT WOS:000317612600011 ER PT B AU Dzindolet, MT Beck, HP Pierce, LG AF Dzindolet, Mark T. Beck, Hall P. Pierce, Linda G. BE Hayes, CC Miller, CA TI NETWORK OPERATIONS Developing Trust in Human and Computer Agents SO Human-Computer Etiquette: Cultural Expectations and the Design Implications They Place on Computers and Technology SE Supply Chain Integration Series LA English DT Article; Book Chapter ID 1ST IMPRESSIONS; EXPECTANCY CONFIRMATION; CLOSE RELATIONSHIPS; SOCIAL-PERCEPTION; AUTOMATED-SYSTEMS; ATTRIBUTION; PEOPLE; MEMORY; TASK; FACE C1 [Dzindolet, Mark T.] Cameron Univ, Lawton, OK 73505 USA. [Beck, Hall P.] Appalachian State Univ, Boone, NC 28608 USA. [Pierce, Linda G.] Army Res Inst, Aberdeen, MD USA. RP Dzindolet, MT (reprint author), Cameron Univ, Lawton, OK 73505 USA. NR 66 TC 0 Z9 0 U1 1 U2 1 PU AUERBACH PUBLICATIONS, TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4200-6946-4; 978-1-4200-6945-7 J9 SUPPLY CHAIN INTEGR PY 2011 BP 145 EP 180 PG 36 WC Cultural Studies; Computer Science, Cybernetics; Information Science & Library Science SC Cultural Studies; Computer Science; Information Science & Library Science GA BD6UQ UT WOS:000362634000007 ER PT B AU Bliss, JP Kring, JP Lampton, DR AF Bliss, James P. Kring, Jason P. Lampton, Donald R. BE Hayes, CC Miller, CA TI ETIQUETTE IN DISTRIBUTED GAME-BASED TRAINING Communication, Trust, Cohesion SO Human-Computer Etiquette: Cultural Expectations and the Design Implications They Place on Computers and Technology SE Supply Chain Integration Series LA English DT Article; Book Chapter ID COMPUTER-MEDIATED COMMUNICATION; SMALL TASK GROUPS; FACE-TO-FACE; PERCEIVED COHESION; PERFORMANCE; COHESIVENESS; ENVIRONMENT; AUTOMATION; GENDER; SINGLE C1 [Bliss, James P.] Old Dominion Univ, Norfolk, VA 23529 USA. [Kring, Jason P.] Embry Riddle Aeronaut Univ, Daytona Beach, FL USA. [Lampton, Donald R.] Army Res Inst, Orlando Field Unit, Orlando, FL USA. RP Bliss, JP (reprint author), Old Dominion Univ, Norfolk, VA 23529 USA. NR 51 TC 0 Z9 0 U1 0 U2 0 PU AUERBACH PUBLICATIONS, TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4200-6946-4; 978-1-4200-6945-7 J9 SUPPLY CHAIN INTEGR PY 2011 BP 181 EP 202 PG 22 WC Cultural Studies; Computer Science, Cybernetics; Information Science & Library Science SC Cultural Studies; Computer Science; Information Science & Library Science GA BD6UQ UT WOS:000362634000008 ER PT J AU Tracy, FT AF Tracy, Fred T. BE Elango, L TI Analytical and Numerical Solutions of Richards' Equation with Discussions on Relative Hydraulic Conductivity SO HYDRAULIC CONDUCTIVITY - ISSUES, DETERMINATION AND APPLICATIONS LA English DT Article; Book Chapter C1 [Tracy, Fred T.] US Army Engineer Res & Dev Ctr, Champaign, IL 61822 USA. RP Tracy, FT (reprint author), US Army Engineer Res & Dev Ctr, Champaign, IL 61822 USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU INTECH EUROPE PI RIJEKA PA JANEZA TRDINE9, RIJEKA, 51000, CROATIA BN 978-953-307-288-3 PY 2011 BP 203 EP 222 D2 10.5772/744 PG 20 WC Geology; Water Resources SC Geology; Water Resources GA BD8AL UT WOS:000363726500012 ER PT J AU Ding, HP Chen, G Majumdar, AK Sadler, BM Xu, ZY AF Ding, Haipeng Chen, Gang Majumdar, Arun K. Sadler, Brian M. Xu, Zhengyuan TI Modeling of Non-Line-of-Sight Ultraviolet Scattering Channels for Communication (vol 27, pg 1535, 2009) SO IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS LA English DT Correction C1 [Ding, Haipeng; Chen, Gang; Xu, Zhengyuan] Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. [Majumdar, Arun K.] USN, Air Warfare Ctr, Weap Div, China Lake, CA 93555 USA. [Sadler, Brian M.] USA, Res Lab, RDRL CIN, Adelphi, MD 20783 USA. RP Ding, HP (reprint author), Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. EM dxu@ee.ucr.edu; arun.majumdar@navy.mil; brian.sadler@us.army.mil RI Ding, Haipeng/B-7742-2014 NR 1 TC 2 Z9 3 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0733-8716 J9 IEEE J SEL AREA COMM JI IEEE J. Sel. Areas Commun. PD JAN PY 2011 VL 29 IS 1 BP 250 EP 250 DI 10.1109/JSAC.2011.110123 PG 1 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 701TH UT WOS:000285845800023 ER PT J AU Prokopenko, O Bankowski, E Meitzler, T Tiberkevich, V Slavin, A AF Prokopenko, Oleksandr Bankowski, Elena Meitzler, Thomas Tiberkevich, Vasil Slavin, Andrei TI Spin-Torque Nano-Oscillator as a Microwave Signal Source SO IEEE MAGNETICS LETTERS LA English DT Article DE Spin electronics; oscillators; electromagnetic radiation; phase-locked oscillators AB We evaluate a possibility to use spin-torque nano-oscillators (STNOs) and oscillator arrays as new sources of microwave signals for telecommunication devices. The microwave signal generated by STNO can be received as oscillation of the device magnetoresistance (MR) or as direct electromagnetic emission of two effective magnetic dipoles. We calculate the dipolar microwave power emitted by STNO in free space and in several types of transmission lines and resonators. We demonstrate that although the power of a single STNO received through the MR effect is, typically, larger than the power of direct microwave emission of effective dipoles, the latter mechanism might have an advantage for sufficiently large arrays of coupled STNOs. C1 [Prokopenko, Oleksandr] Natl Taras Shevchenko Univ Kyiv, Fac Radiophys, UA-01601 Kiev, MSP, Ukraine. [Bankowski, Elena; Meitzler, Thomas] US Army TARDEC, Warren, MI 48397 USA. [Tiberkevich, Vasil; Slavin, Andrei] Oakland Univ, Dept Phys, Rochester, MI 48309 USA. RP Tiberkevich, V (reprint author), Oakland Univ, Dept Phys, Rochester, MI 48309 USA. EM tyberkev@oakland.edu RI Tiberkevich, Vasil/A-8697-2008; OI Tiberkevich, Vasil/0000-0002-8374-2565; Meitzler, Thomas/0000-0002-0730-3958 FU U.S. Army TARDEC, RDECOM [W56HZW-09-PL564]; National Science Foundation of the USA [ECCS-0653901]; Oakland University Foundation; Ministry of Education and Science of Ukraine [M/175-2007] FX This work was supported in part by the Contract No. W56HZW-09-PL564 from the U.S. Army TARDEC, RDECOM, in part by the Grant No. ECCS-0653901 from the National Science Foundation of the USA, in part by the Oakland University Foundation, and in part by the Grant No. M/175-2007 from the Ministry of Education and Science of Ukraine. NR 14 TC 13 Z9 13 U1 2 U2 8 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1949-307X J9 IEEE MAGN LETT JI IEEE Magn. Lett. PY 2011 VL 2 AR 3000104 DI 10.1109/LMAG.2010.2102007 PG 4 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA V31VE UT WOS:000208910300003 ER PT J AU Park, SJ Ross, JA Shires, DR Richie, DA Henz, BJ Nguyen, LH AF Park, Song Jun Ross, James A. Shires, Dale R. Richie, David A. Henz, Brian J. Nguyen, Lam H. TI Hybrid Core Acceleration of UWB SIRE Radar Signal Processing SO IEEE TRANSACTIONS ON PARALLEL AND DISTRIBUTED SYSTEMS LA English DT Article DE Heterogeneous (hybrid) systems; emerging technologies; signal processing systems; computers in other systems-military AB To move High-Performance Computing (HPC) closer to forward operating environments and missions, the Army Research Laboratory is developing approaches using hybrid, asymmetric core computing. By blending capabilities found in Graphics Processing Units (GPUs) and traditional von Neumann multicore Central Processing Units (CPUs), approaches are being developed and optimized to provide at or near real-time processing speeds for research project applications. Algorithms are designed to partition work to resources best designed to handle the processing load. The use of commodity resources allows the design to be flexible throughout the life cycle without the costly and time-consuming delays associated with Application-Specific Integrated Circuit (ASIC) development. This paradigm allows for rapid technology transfer to end users. In this paper, we describe a synchronous impulse reconstruction radar imaging algorithm that has been designed for hybrid CPU-GPU processing. We discuss various optimizations such as asynchronous task partitioning between the CPU and GPU as well as data movement reduction. We also discuss analysis and design of the algorithms within the context of two programming models: NVIDIA's CUDA and AMD's ATI Brook+. Finally, we report on the speedup achieved by this approach that allowed us to take a code once restricted to postprocessing and transform it into one that exceeds real-time performance requirements. C1 [Park, Song Jun; Shires, Dale R.; Henz, Brian J.; Nguyen, Lam H.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Ross, James A.] High Performance Technol Inc, Aberdeen Proving Ground, MD 21005 USA. [Richie, David A.] Brown Deer Technol, Forest Hill, MD 21050 USA. RP Park, SJ (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM song.jun.park@us.army.mil; jross@hpti.com; dale.shires@us.army.mil; drichie@browndeertechnology.com; brian.j.henz@us.army.mil; lam.nguyen@us.army.mil FU Department of Defense High Performance Computing Modernization Program Office (HPCMPO) FX The authors thank the Department of Defense High Performance Computing Modernization Program Office (HPCMPO) for support offered through the User Productivity Enhancement, Technology Transfer, and Training (PET3) program. NR 22 TC 7 Z9 8 U1 0 U2 4 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1045-9219 J9 IEEE T PARALL DISTR JI IEEE Trans. Parallel Distrib. Syst. PD JAN PY 2011 VL 22 IS 1 BP 46 EP 57 DI 10.1109/TPDS.2010.117 PG 12 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 682SS UT WOS:000284423900006 ER PT J AU Karvetski, CW Lambert, JH Keisler, JM Linkov, I AF Karvetski, Christopher W. Lambert, James H. Keisler, Jeffrey M. Linkov, Igor TI Integration of Decision Analysis and Scenario Planning for Coastal Engineering and Climate Change SO IEEE TRANSACTIONS ON SYSTEMS MAN AND CYBERNETICS PART A-SYSTEMS AND HUMANS LA English DT Article DE Climate change; coastal engineering; multicriteria decision analysis; rank weight ID SEA-LEVEL RISE; VULNERABILITY ASSESSMENT; PREFERENCES; INFORMATION; MANAGEMENT; USA AB This paper develops a methodology for eliciting shifts in preference across future scenarios in the performance assessment of infrastructure policies and investments. The methodology quantifies the robustness of alternative portfolios across a variety of scenarios and identifies the scenarios that greatly affect the assessments. An innovation of the methodology is to elicit, for each scenario, only a few relative increases or decreases in importance of selected terms of the value function, which is more efficient than a full elicitation of the value function for each scenario. The identification of critical scenarios via our methodology can be used to focus resource-intensive and potentially costly modeling activities. The methodology integrates preference orders, centroid weights, and the Borda method. In a demonstration, the methodology assesses the relative sea level and other climate-change scenarios that could affect the performance of coastal protections. C1 [Karvetski, Christopher W.; Lambert, James H.] Univ Virginia, Ctr Risk Management Engn Syst, Charlottesville, VA 22904 USA. [Keisler, Jeffrey M.] Univ Massachusetts, Coll Management, Boston, MA 02125 USA. [Linkov, Igor] USA, Corps Engineers, Washington, DC 20314 USA. RP Karvetski, CW (reprint author), Univ Virginia, Ctr Risk Management Engn Syst, Charlottesville, VA 22904 USA. EM cwk5b@virginia.edu; lambert@virginia.edu; jeff.keisler@umb.edu; Igor.Linkov@usace.army.mil FU U.S. Army Engineer Research and Development Center FX Manuscript received August 31, 2009; accepted March 7, 2010. Date of publication August 12, 2010; date of current version November 10, 2010. This work was supported in part by the Civil Works Basic Research Program of the U.S. Army Engineer Research and Development Center. Permission was granted by the USACE Chief of Engineers to publish this material. The views and opinions expressed in this paper are those of the individual authors and not those of the U.S. Army or other sponsor organizations. This paper was recommended by Associate Editor K. W. Hipel. NR 38 TC 27 Z9 30 U1 0 U2 9 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1083-4427 J9 IEEE T SYST MAN CY A JI IEEE Trans. Syst. Man Cybern. Paart A-Syst. Hum. PD JAN PY 2011 VL 41 IS 1 BP 63 EP 73 DI 10.1109/TSMCA.2010.2055154 PG 11 WC Computer Science, Cybernetics; Computer Science, Theory & Methods SC Computer Science GA 678QQ UT WOS:000284095400006 ER PT J AU Friberg, H Burns, L Woda, M Kalayanarooj, S Endy, TP Stephens, HAF Green, S Rothman, AL Mathew, A AF Friberg, Heather Burns, Lynne Woda, Marcia Kalayanarooj, Siripen Endy, Timothy P. Stephens, Henry A. F. Green, Sharone Rothman, Alan L. Mathew, Anuja TI Memory CD8(+) T cells from naturally acquired primary dengue virus infection are highly cross-reactive SO IMMUNOLOGY AND CELL BIOLOGY LA English DT Article DE antigens/peptides/epitopes; human; signal transduction; T cells; viral ID DISEASE SEVERITY; HEMORRHAGIC-FEVER; CYTOKINE RESPONSES; LYMPHOCYTE RESPONSES; IMMUNE ACTIVATION; VARIANT PEPTIDES; HLA-A; CORRELATE; SEROTYPE; EPITOPES AB Cross-reactive memory T cells induced by primary infection with one of the four serotypes of dengue virus (DENV) are hypothesized to have an immunopathological function in secondary heterologous DENV infection. To define the T-cell response to heterologous serotypes, we isolated HLA-A*1101-restricted epitope-specific CD8(+) T-cell lines from primary DENV-immune donors. Cell lines exhibited marked cross-reactivity toward peptide variants representing the four DENV serotypes in tetramer binding and functional assays. Many clones responded similarly to homologous and heterologous serotypes with striking cross-reactivity between the DENV-1 and DENV-3 epitope variants. In vitro-stimulated T-cell lines consistently revealed a hierarchical induction of MIP-1 beta>degranulation>tumor necrosis factor alpha (TNF alpha)>interferon-gamma (IFN gamma), which depended on the concentration of agonistic peptide. Phosphoflow assays showed peptide dose-dependent phosphorylation of ERK1/2, which correlated with cytolysis, degranulation, and induction of TNF alpha and IFN gamma, but not MIP-1 beta production. This is the first study to show significant DENV serotype-cross-reactivity of CD8(+) T cells after naturally acquired primary infection. We also show qualitatively different T-cell receptor signaling after stimulation with homologous and heterologous peptides. Our data support a model whereby the order of sequential DENV infections influences the immune response to secondary heterologous DENV infection, contributing to varying disease outcomes. Immunology and Cell Biology (2011) 89, 122-129; doi:10.1038/icb.2010.61; published online 27 April 2010 C1 [Friberg, Heather; Burns, Lynne; Woda, Marcia; Green, Sharone; Rothman, Alan L.; Mathew, Anuja] Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA 01655 USA. [Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. [Endy, Timothy P.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Stephens, Henry A. F.] UCL, Ctr Nephrol & Anthony Nolan Trust, London, England. RP Mathew, A (reprint author), Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, S6-862,55 Lake Ave N, Worcester, MA 01655 USA. EM anuja.mathew@umassmed.edu FU National Institutes of Health [P01 AI34533, U19 AI57319]; Diabetes Endocrinology Research Center [P30 DK032520] FX This work was funded by the National Institutes of Health, grants P01 AI34533 and U19 AI57319. Core resources supported by the Diabetes Endocrinology Research Center grant P30 DK032520 were used. We thank the donors who generously provided PBMC for use in our studies. We thank Drs Suchitra Nimmannitya and David Vaughn, as well as the staffs of the Queen Sirikit National Institute for Child Health, the Department of Virology, Armed Forces Research Institute of Medical Sciences, and the Department of Transfusion Medicine, Siriraj Hospital, for patient recruitment, blood collection, and clinical, virology, and HLA information. We also thank Joyce Pepe, Jim Coderre, Thomas Greenough, and the UMass Tetramer Core for giving their time and effort to generate the tetramers used here, Pam Pazoles and the UMass Flow Cytometry Core for help with flow cytometry data collection, and Kim West for help with cell culture. NR 45 TC 26 Z9 26 U1 0 U2 2 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0818-9641 J9 IMMUNOL CELL BIOL JI Immunol. Cell Biol. PD JAN PY 2011 VL 89 IS 1 BP 122 EP 129 DI 10.1038/icb.2010.61 PG 8 WC Cell Biology; Immunology SC Cell Biology; Immunology GA 703FC UT WOS:000285961900018 PM 20421879 ER PT J AU Gilbert, C Pauline, S Radovan, K Raed, A Khaldoun, A AF Gilbert, Chahine Pauline, Smith Radovan, Kovacevic Raed, Ajlouni Khaldoun, Ajlouni BE Turkyilmaz, I TI Digital Engineering of Bio-Adaptable Dental Implants SO IMPLANT DENTISTRY - A RAPIDLY EVOLVING PRACTICE LA English DT Article; Book Chapter ID FINITE-ELEMENT-ANALYSIS; RECONSTRUCTED MANDIBULAR MODELS; STRESS-DISTRIBUTION; BONE; TITANIUM; OSSEOINTEGRATION; RESTORATIONS; PROSTHESES; DIAMETER; LENGTH C1 [Gilbert, Chahine; Radovan, Kovacevic] So Methodist Univ, Dallas, TX 75275 USA. [Pauline, Smith] Army Res Lab, Aberdeen, MD USA. [Raed, Ajlouni; Khaldoun, Ajlouni] Baylor Coll Dent, Dallas, TX 75246 USA. RP Gilbert, C (reprint author), So Methodist Univ, Dallas, TX 75275 USA. NR 66 TC 0 Z9 0 U1 0 U2 0 PU INTECH EUROPE PI RIJEKA PA JANEZA TRDINE9, RIJEKA, 51000, CROATIA BN 978-953-307-658-4 PY 2011 BP 251 EP 266 D2 10.5772/706 PG 16 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA BE5JQ UT WOS:000372912800011 ER PT B AU Bachmann, CH AF Bachmann, Chris H. BE Callaos, N Carrasquero, JV Oropeza, A Tremante, A Welsch, F TI Using Learning Styles as a Group Selection Technique SO IMSCI'11: THE 5TH INTERNATIONAL MULTI-CONFERENCE ON SOCIETY, CYBERNETICS AND INFORMATICS, VOL II LA English DT Proceedings Paper CT 5th International Multi-Conference on Society, Cybernetics and Information (IMSCI 2011) CY JUL 19-22, 2011 CL Orlando, FL SP Int Inst Informat & Syst DE Learning Styles and Group Selection Techniques AB Undergraduate and graduate programs often dedicate part of a course's graded requirements to group projects. In SE481, a discrete event simulation course taught at the United States Military Academy, 50% of the course grade comes from group projects. Due to the large amount of the course dedicated to group work, it is important to consider how students are grouped for these projects. A common technique used to group students is allowing them to self-select their group members. Students usually prefer this method, and it is easy to argue that this would lead to better performance because of better group dynamics. However, a brief review of the research on this topic refutes this argument. The research on this topic favors grouping students based on their learning style. In order to confirm which of these two grouping methods is superior, the author conducted an experiment over two academic terms with five sections of SE481 students. The results of this research support using learning styles as a grouping technique. C1 [Bachmann, Chris H.] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. NR 14 TC 0 Z9 0 U1 0 U2 0 PU INT INST INFORMATICS & SYSTEMICS PI ORLANDO PA 14269 LORD BARCLAY DR, ORLANDO, FL 32837 USA BN 978-1-936338-34-4 PY 2011 BP 65 EP 69 PG 5 WC Computer Science, Cybernetics; Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BG8PD UT WOS:000392562700013 ER PT J AU Strater, LD Cuevas, HM Scielzo, S Connors, ES Gonzalez, C Ungvarsky, DM Endsley, MR AF Strater, Laura D. Cuevas, Haydee M. Scielzo, Sandro Connors, Erik S. Gonzalez, Cleotilde Ungvarsky, Diane M. Endsley, Mica R. BE Mosier, KL Fischer, UM TI An Investigation of Technology-Mediated Ad Hoc Team Operations Consideration of Components of Team Situation Awareness SO INFORMED BY KNOWLEDGE: EXPERT PERFORMANCE IN COMPLEX SITUATIONS LA English DT Proceedings Paper CT 8th International Conference on Naturalistic Decision Making (NDM) CY JUN 03-06, 2007 CL Pacific Grove, CA ID DYNAMIC-SYSTEMS C1 [Strater, Laura D.; Cuevas, Haydee M.; Scielzo, Sandro; Connors, Erik S.; Endsley, Mica R.] SA Technol, Santa Clara, CA 95054 USA. [Gonzalez, Cleotilde] Carnegie Mellon Univ, Dynam Decis Making Lab, Pittsburgh, PA 15213 USA. [Ungvarsky, Diane M.] US Army Res Lab, Adelphi, MD USA. RP Strater, LD (reprint author), SA Technol, Santa Clara, CA 95054 USA. FU Advanced Decision Architectures Collaborative Technology Alliance - U.S. Army Research Laboratory (ARL) [DAAD19-01-2-0009] FX The authors thank Michelle L. Tinsley for her editorial assistance on this paper. Work on this paper was partially supported by funding through participation in the Advanced Decision Architectures Collaborative Technology Alliance sponsored by the U.S. Army Research Laboratory (ARL) under Cooperative Agreement DAAD19-01-2-0009. The views and conclusions contained herein, however, are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the ARL, U.S. Army, U.S. Department of Defense, U.S. government, or the organizations with which the authors are affiliated. NR 19 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE PI ABINGDON PA 2 PARK SQ, MILTON PARK, ABINGDON OX14 4RN, OXFORD, ENGLAND BN 978-1-13694-511-3 PY 2011 BP 153 EP 168 PG 16 WC Engineering, Industrial; Psychology, Applied SC Engineering; Psychology GA BG9BI UT WOS:000392974000010 ER PT S AU Connelly, BC Metcalfe, GD Shen, HG Wraback, M AF Connelly, Blair C. Metcalfe, Grace D. Shen, Hongen Wraback, Michael BE LeVanPaul, D Sood, AK Wijewarnasuriya, PS Razeghi, M Vizcaino, JLP Sudharsanan, R Ulmer, MP Manzur, T TI Study of recombination mechanisms limiting the performance of Sb-based III-V type II superlattices for infrared detectors SO INFRARED SENSORS, DEVICES, AND APPLICATIONS AND SINGLE PHOTON IMAGING II SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Infrared Sensors, Devices, and Applications and Single Photon Imaging II CY AUG 22-25, 2011 CL San Diego, CA SP SPIE DE Time-resolved photoluminescence; minority carrier lifetime; type II superlattices; recombination mechanisms; infrared; focal plane arrays; Shockley-Read-Hall ID MINORITY-CARRIER LIFETIME; PHOTOLUMINESCENCE DECAY; SEMICONDUCTORS AB Time-resolved photoluminescence measurements are used to study minority carrier lifetimes in type II superlattices (T2-SL) to investigate the recombination mechanisms that currently limit their performance. Time-domain measurements of the photoluminescence signal demonstrate multiple exponential decay, which provide information on background carriers, acceptor states and trap states. The temperature dependence of the TRPL signal shows that the carrier lifetime is dominated by Shockley-Read-Hall recombination. Optimal sample design for photoluminescence measurements is discussed. Photoluminescence measurements and modeling of the time-resolved signal in device structures demonstrate that the restoring current in a narrow bandgap junction dominates the carrier recombination, leading to measured lifetimes that are ostensibly long. Experimental results are presented on T2-SL samples that vary the superlattice absorber width and doping level. The effect of the interface type on carrier lifetime is investigated in multiple quantum well structures. Variations of the absorber width, doping level and interface type are not found to strongly influence the carrier lifetime. C1 [Connelly, Blair C.; Metcalfe, Grace D.; Shen, Hongen; Wraback, Michael] USA, Res Lab, RDRL SEE M, Adelphi, MD 20783 USA. RP Connelly, BC (reprint author), USA, Res Lab, RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM blair.connelly.ctr@mail.mil NR 21 TC 6 Z9 6 U1 1 U2 7 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-765-0 J9 PROC SPIE PY 2011 VL 8155 AR 81550L DI 10.1117/12.893964 PG 10 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA BXF58 UT WOS:000295966100019 ER PT J AU Kalkur, TS Sbrockey, N Tompa, GS Cole, MW AF Kalkur, T. S. Sbrockey, N. Tompa, G. S. Cole, M. W. TI Tunable RF Filters Fabricated Using MOCVD Deposited Graded Composition BST Films SO INTEGRATED FERROELECTRICS LA English DT Article DE Ferroelectric; Thin Films; Compositional Graded; BST; Tunable; RF Filters AB Compositionally graded Barium Strontium Titanate (BST) thin films were deposited by MOCVD on r-plane sapphire substrates with patterned platinum electrodes. Tunable parallel plate capacitors were fabricated using these films by ion-milling and photolithography. The capacitors show a tunability of 36% for an electric field of +/- 13V at a measurement frequency of 1 MHz. These tunable capacitors were integrated with resonators fabricated on FR-4 substrates to form tunable RF filters. Characterization of the filters shows that the center frequency can be tuned from 3.710 GHz to 4.062 GHz by applying a tunable bias of 12 volts. C1 [Kalkur, T. S.] Univ Colorado, Dept Elect & Comp Engn, Microelect Res Labs, Colorado Springs, CO 80933 USA. [Sbrockey, N.; Tompa, G. S.] Struct Mat Ind Inc, Piscataway, NJ 08854 USA. [Cole, M. W.] USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Kalkur, TS (reprint author), Univ Colorado, Dept Elect & Comp Engn, Microelect Res Labs, Colorado Springs, CO 80933 USA. EM kalkur@eas.uccs.edu FU Structured Materials Industries, Inc. through US Army Research Office [W911NF-08-C-0124] FX This work was funded by Structured Materials Industries, Inc., through contract number W911NF-08-C-0124 from the US Army Research Office. NR 11 TC 8 Z9 10 U1 1 U2 7 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1058-4587 J9 INTEGR FERROELECTR JI Integr. Ferroelectr. PY 2011 VL 126 BP 28 EP 33 DI 10.1080/10584587.2011.574978 PG 6 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA 847XV UT WOS:000297009700006 ER PT J AU Cole, MW Toonen, RC Hirsch, SG Ivill, M Ngo, E Hubbard, C Ramanathan, S Podpirka, A AF Cole, M. W. Toonen, R. C. Hirsch, S. G. Ivill, M. Ngo, E. Hubbard, C. Ramanathan, S. Podpirka, A. TI An Elegant Post-Growth Process Science Protocol to Improve the Material Properties of Complex Oxide Thin Films for Tunable Device Applications SO INTEGRATED FERROELECTRICS LA English DT Article DE BST; phase shifter; microwave devices; thin film processing; UV-photon irradiation; dielectric loss; material property balance ID DIELECTRIC-PROPERTIES; TUNABILITY AB We report on an innovative isothermal post-growth/crystallization process that utilizes ultraviolet (UV)-photon irradiation. We fabricated Ba(1-x)Sr(x)TiO(3) (BST) thin films using metalorganic solution deposition (MOSD) and UV-photon irradiation isothermal treatment via two protocols: in situ crystallized UV-photon irradiated films, and post-crystallization UV-photon irradiated films. Isothermal UV-photon irradiation treatment improves the structural quality of the BST films, and the irradiated films possessed lattice parameters close to the bulk values, which is evidence for a reduction in oxygen vacancies. MOSD fabricated BST films crystallized via conventionally furnace annealing and subsequently exposed to UV-photon irradiation possessed improved structural, dielectric, and electrical quality. C1 [Cole, M. W.; Toonen, R. C.; Hirsch, S. G.; Ivill, M.; Ngo, E.; Hubbard, C.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Ramanathan, S.; Podpirka, A.] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA. RP Cole, MW (reprint author), USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM mel.cole@us.army.mil OI Podpirka, Adrian/0000-0002-4000-989X NR 19 TC 1 Z9 1 U1 0 U2 7 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1058-4587 J9 INTEGR FERROELECTR JI Integr. Ferroelectr. PY 2011 VL 126 BP 34 EP 46 DI 10.1080/10584587.2011.574982 PG 13 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA 847XV UT WOS:000297009700007 ER PT J AU Serge, A de Keijzer, S Van Hemert, F Hickman, MR Hereld, D Spaink, HP Schmidt, T Snaar-Jagalska, BE AF Serge, Arnauld de Keijzer, Sandra Van Hemert, Freek Hickman, Mark R. Hereld, Dale Spaink, Herman P. Schmidt, Thomas Snaar-Jagalska, B. Ewa TI Quantification of GPCR internalization by single-molecule microscopy in living cells SO INTEGRATIVE BIOLOGY LA English DT Article ID PROTEIN-COUPLED RECEPTORS; DICTYOSTELIUM-DISCOIDEUM CELLS; LIGAND-INDUCED PHOSPHORYLATION; SURFACE CAMP RECEPTORS; CYCLIC-AMP RECEPTORS; CHEMOATTRACTANT RECEPTORS; SIGNAL-TRANSDUCTION; DOWN-REGULATION; 7-TRANSMEMBRANE RECEPTORS; CAR1 AB Receptor internalization upon ligand stimulation is a key component of a cell's response and allows a cell to correctly sense its environment. Novel fluorescent methods have enabled the direct visualization of the agonist-stimulated G-protein-coupled receptors (GPCR) trafficking in living cells. However, it is difficult to observe internalization of GPCRs in vivo due to intrinsic autofluorescence and cytosolic signals of fluorescently labeled GPCRs. This study uses the superior positional accuracy of single-molecule fluorescence microscopy to visualize in real time the internalization of Dictyostelium discoideum cAMP receptors, cAR1, genetically encoded with eYFP. This technique made it possible to follow the number of receptors in time revealing that the fraction of cytosolic receptors increases after persistent agonist stimulation and that the majority of the receptors were degraded after internalization. The observed internalization process was phosphorylation dependent, as shown with the use of a phosphorylation deficient cAR1 mutant, cm1234-eYFP, or stimulation with an antagonist, Rp-cAMPS that does not induce receptor phosphorylation. Furthermore, experiments done in mound-stage cells suggest that intrinsic, phosphorylation-induced internalization of cAR1 is necessary for Dictyostelium wild type cells to progress properly through multicellular development. To our knowledge, this observation illustrates for the first time phosphorylation-dependent internalization of single cAR1 molecules in living cells and its involvement in multicellular development. This very sensitive imaging of receptor internalization can be a useful and universal approach for pharmacological characterization of GPCRs in other cell types. C1 [Serge, Arnauld; de Keijzer, Sandra; Van Hemert, Freek; Schmidt, Thomas] Leiden Univ, Leiden Inst Phys, Leiden, Netherlands. [de Keijzer, Sandra; Van Hemert, Freek; Spaink, Herman P.; Snaar-Jagalska, B. Ewa] Leiden Univ, IBL Mol Cell Biol, Gorlaeus Lab, NL-2333 CC Leiden, Netherlands. [Hickman, Mark R.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Hereld, Dale] NIAAA, Div Metab & Hlth Effects, Rockville, MD 20852 USA. RP Serge, A (reprint author), Leiden Univ, Leiden Inst Phys, POB 9504, Leiden, Netherlands. EM B.E.Snaar-Jagalska@biology.leidenuniv.nl RI Schmidt, Thomas/B-6296-2009; OI Schmidt, Thomas/0000-0002-0045-1851; Serge, Arnauld/0000-0003-4271-3706 FU Marie-Curie fellowship; Netherlands Organisation for Scientific Research, Chemical Sciences; American Heart Association, Texas Affiliate [0265158Y] FX We thank P. N. Devreotes and Minghang Zhang for providing us with cAR1-YFP and cm1234-YFP constructs, respectively. This work was supported by the Marie-Curie fellowship (to A. S.), Netherlands Organisation for Scientific Research, Chemical Sciences (to S. K) and by grant 0265158Y from the American Heart Association, Texas Affiliate (to D.H.). NR 50 TC 14 Z9 14 U1 0 U2 8 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1757-9694 J9 INTEGR BIOL-UK JI Integr. Biol. PY 2011 VL 3 IS 6 BP 675 EP 683 DI 10.1039/c0ib00121j PG 9 WC Cell Biology SC Cell Biology GA 773OV UT WOS:000291317500006 PM 21541374 ER PT S AU Chan, AL AF Chan, Alex Lipchen BE Roning, J Casasent, DP Hall, EL TI Detecting Stationary Human Targets in FLIR Imagery SO INTELLIGENT ROBOTS AND COMPUTER VISION XXVIII: ALGORITHMS AND TECHNIQUES SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Intelligent Robots and Computer Vision XXVIII: Algorithms and Techniques CY JAN 24-25, 2011 CL San Francisco, CA SP SPIE, Soc Imaging Sci & Technol (IS&T) DE Stationary human detection; multi-stage; clutter rejection; neural network; FLIR imagery ID NEURAL-NETWORK AB In the military arena, intelligent unmanned ground vehicles (UGVs), weighing 10 tons or more, may be designed and used for transportation or combat purposes. To ensure safe operations among civilians and friendly combatants, it is crucial for these UGVs to detect and avoid humans who might be injured unintentionally. In this paper, a multi-stage detection algorithm for stationary humans in forward-looking infrared (FLIR) imagery is proposed. This algorithm first applies an efficient feature-based anomalies detection algorithm to search the entire input image, which is followed by an eigen-neural-based clutter rejecter that examines only the portions of the input image identified by the first algorithm, and culminates with a simple evidence integrator that combines the results from the two previous stages. The proposed algorithm was evaluated using a large set of challenging FLIR images and the results support the usefulness of this multi-stage architecture. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Chan, AL (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 12 TC 0 Z9 0 U1 1 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-415-4 J9 PROC SPIE PY 2011 VL 7878 AR 78780P DI 10.1117/12.872496 PG 9 WC Computer Science, Artificial Intelligence; Optics SC Computer Science; Optics GA BXX85 UT WOS:000297557600021 ER PT S AU Theisen, BL Frederick, P Smuda, W AF Theisen, Bernard L. Frederick, Philip Smuda, William BE Roning, J Casasent, DP Hall, EL TI The 18TH Annual Intelligent Ground Vehicle Competition: Trends and Influences for Intelligent Ground Vehicle Control SO INTELLIGENT ROBOTS AND COMPUTER VISION XXVIII: ALGORITHMS AND TECHNIQUES SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Intelligent Robots and Computer Vision XXVIII: Algorithms and Techniques CY JAN 24-25, 2011 CL San Francisco, CA SP SPIE, Soc Imaging Sci & Technol (IS&T) DE intelligent robots; autonomous systems; ground vehicles; vehicle control; engineering education; IGVC AB The Intelligent Ground Vehicle Competition (IGVC) is one of four, unmanned systems, student competitions that were founded by the Association for Unmanned Vehicle Systems International (AUVSI). The IGVC is a multidisciplinary exercise in product realization that challenges college engineering student teams to integrate advanced control theory, machine vision, vehicular electronics and mobile platform fundamentals to design and build an unmanned system. Teams from around the world focus on developing a suite of dual-use technologies to equip ground vehicles of the future with intelligent driving capabilities. Over the past 18 years, the competition has challenged undergraduate, graduate and Ph.D. students with real world applications in intelligent transportation systems, the military and manufacturing automation. To date, teams from over 75 universities and colleges have participated. This paper describes some of the applications of the technologies required by this competition and discusses the educational benefits. The primary goal of the IGVC is to advance engineering education in intelligent vehicles and related technologies. The employment and professional networking opportunities created for students and industrial sponsors through a series of technical events over the four-day competition are highlighted. Finally, an assessment of the competition based on participation is presented. C1 [Theisen, Bernard L.; Frederick, Philip; Smuda, William] USA, TARDEC, Warren, MI 48397 USA. RP Theisen, BL (reprint author), USA, TARDEC, 6501 E 11 Mile Rd, Warren, MI 48397 USA. EM bernard.theisen@us.army.mil; philip.frederik@us.army.mil; bill.smuda@us.army.mil NR 13 TC 0 Z9 0 U1 1 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-415-4 J9 PROC SPIE PY 2011 VL 7878 AR 787804 DI 10.1117/12.878773 PG 15 WC Computer Science, Artificial Intelligence; Optics SC Computer Science; Optics GA BXX85 UT WOS:000297557600003 ER PT J AU Brawner, KW Gonzalez, A AF Brawner, Keith W. Gonzalez, Avelino BE Bruzzone, A Buck, W Sokolowski, JA TI REALTIME CLUSTERING OF UNLABELLED SENSORY DATA FOR TRAINEE STATE ASSESSMENT SO INTERNATIONAL DEFENSE AND HOMELAND SECURITY SIMULATION WORKSHOP, (DHSS 2011) LA English DT Proceedings Paper CT International Defense and Homeland Security Simulation Workshop (DHSS) CY SEP 12-14, 2011 CL Rome, ITALY SP Univ Genoa, DIPTEM, Liophant Simulat, Simulat Team, Int Mediterranean & Latin Amer Council Simulat, Univ Calabria, Mech Dept, Lab Enterprise Solut, Modeling & Simulat Ctr, Modeling & Simulat Ctr Excellence, Riga Tech Univ, MISS Lativan Ctr, LOGISIM, Lab Sci Informat Syst, Movimento Italiano Modellazione Simulazione, Univ Perugia, McLeod Inst SImulat Sci, McLeod Inst SImulat Sci, Brasilian Ctr, LAMCE COPPE UFRJ, McLeod Inst SImulat Sci, Mcleod Modeling & Simulat Network, Lativan Simulat Soc, Ecole Super Ingn Sci Appliquees, Fac Ciencia Exactas Ingn Agrimensura, Univ Laguna, CIFASIS CONICET UNR UPCAM, Inst Syst & Technologies Informat Control & Commun DE Intelligent Tutoring; Realtime Data Streams; Trainee State Assessment; Machine Learning AB The grand challenge of Intelligent Tutoring Systems (ITS) development is that of creating a computer tutor as good as a human tutor. This difficult task may be broken into several parts. The first task real instructors perform prior to making instructional decisions is assessing the state of the trainee. Thus, the first consideration in the construction of an ITS is obtaining meaningful data from sensors and interpreting them in order to assess trainee emotional state. The interpretation of sensor data is the significant problem in this area, with the problem of sensor data mostly having been reduced to sensor selection. The machine learning methods for interpreting unlabelled sensor data are significantly more sparse than the sensors available, and their selection is far from straightforward. In this paper, Growing Neural Gas (GNG) methods, two types of incremental clustering, and Adaptive Resonance Theory (ART) will be evaluated against each other on fabricated and realtime data streams of trainees. state in order to determine the best selection of methods to accomplish this task. C1 [Brawner, Keith W.] Army Res Lab, Human Res & Engn Directorate, Orlando, FL 32816 USA. [Gonzalez, Avelino] Univ Cent Florida, Orlando, FL 32826 USA. RP Brawner, KW (reprint author), Army Res Lab, Human Res & Engn Directorate, Orlando, FL 32816 USA. EM Keith.W.Brawner@us.army.mil; Gonzalez@ucf.edu FU Army's Simulation and Training Technology Center; University of Central Florida FX The lead author would like to thank the Army's Simulation and Training Technology Center and University of Central Florida for continued support and development. Additionally, he would like to thank gromgull, D.S. Blank, Aaron Garrett, and Terry Stewart for parts of the software or software basis used in the above detailed algorithms. NR 14 TC 0 Z9 0 U1 0 U2 0 PU DIPTEM UNIV GENOA PI GENOA PA VIA OPERA OUA 15, GENOA, 16145, ITALY BN 978-88-903724-3-8 PY 2011 BP 33 EP 41 PG 9 WC Operations Research & Management Science SC Operations Research & Management Science GA BG8PN UT WOS:000392603200006 ER PT J AU Holden, HK Goldberg, BS AF Holden, Heather K. Goldberg, Benjamin S. BE Bruzzone, A Buck, W Sokolowski, JA TI THE IMPACT OF STUDENT EXPECTATIONS AND TUTOR ACCEPTANCE ON COMPUTER-BASED LEARNING ENVIRONMENT ACCEPTANCE AND FUTURE USAGE INTENTIONS SO INTERNATIONAL DEFENSE AND HOMELAND SECURITY SIMULATION WORKSHOP, (DHSS 2011) LA English DT Proceedings Paper CT International Defense and Homeland Security Simulation Workshop (DHSS) CY SEP 12-14, 2011 CL Rome, ITALY SP Univ Genoa, DIPTEM, Liophant Simulat, Simulat Team, Int Mediterranean & Latin Amer Council Simulat, Univ Calabria, Mech Dept, Lab Enterprise Solut, Modeling & Simulat Ctr, Modeling & Simulat Ctr Excellence, Riga Tech Univ, MISS Lativan Ctr, LOGISIM, Lab Sci Informat Syst, Movimento Italiano Modellazione Simulazione, Univ Perugia, McLeod Inst SImulat Sci, McLeod Inst SImulat Sci, Brasilian Ctr, LAMCE COPPE UFRJ, McLeod Inst SImulat Sci, Mcleod Modeling & Simulat Network, Lativan Simulat Soc, Ecole Super Ingn Sci Appliquees, Fac Ciencia Exactas Ingn Agrimensura, Univ Laguna, CIFASIS CONICET UNR UPCAM, Inst Syst & Technologies Informat Control & Commun DE technology acceptance; technology expectations; Pedagogical Agents (PAs); Intelligent Tutoring Systems (ITS) ID PEDAGOGICAL AGENTS; COMPANIONS AB Computer-based tutoring systems should be designed to meet/exceed learners' expectations and maximize learners' technology acceptance to increase their satisfaction and future system usage intentions. Pedagogical Agents (PAs) are commonly incorporated into an Intelligent Tutoring System (ITS) to increase learners' satisfaction; however, empirical evidence on the impact of PAs on learner acceptance is limited. Additionally, few ITS researchers seek to understand learners' expectations and acceptance of both the agent and learning environment. This paper presents the results of a study that evaluates the relationships between learner expectations and acceptance of a PA and learning environment both before and after learners' system interactions. C1 [Holden, Heather K.; Goldberg, Benjamin S.] US Army, Res Lab, Human Res & Engn Directorate, Simulat & Training Technol Ctr,LITE Lab, Aberdeen Proving Ground, MD 21001 USA. RP Holden, HK (reprint author), US Army, Res Lab, Human Res & Engn Directorate, Simulat & Training Technol Ctr,LITE Lab, Aberdeen Proving Ground, MD 21001 USA. EM heather.k.holden@us.army.mil; benjamin.s.goldberg@us.army.mil NR 23 TC 0 Z9 0 U1 2 U2 2 PU DIPTEM UNIV GENOA PI GENOA PA VIA OPERA OUA 15, GENOA, 16145, ITALY BN 978-88-903724-3-8 PY 2011 BP 42 EP 47 PG 6 WC Operations Research & Management Science SC Operations Research & Management Science GA BG8PN UT WOS:000392603200007 ER PT J AU Sottilare, RA Goldberg, S Durlach, P AF Sottilare, Robert A. Goldberg, Stephen Durlach, Paula BE Bruzzone, A Buck, W Sokolowski, JA TI RESEARCH GAPS FOR ADAPTIVE AND PREDICTIVE COMPUTER-BASED TUTORING SYSTEMS SO INTERNATIONAL DEFENSE AND HOMELAND SECURITY SIMULATION WORKSHOP, (DHSS 2011) LA English DT Proceedings Paper CT International Defense and Homeland Security Simulation Workshop (DHSS) CY SEP 12-14, 2011 CL Rome, ITALY SP Univ Genoa, DIPTEM, Liophant Simulat, Simulat Team, Int Mediterranean & Latin Amer Council Simulat, Univ Calabria, Mech Dept, Lab Enterprise Solut, Modeling & Simulat Ctr, Modeling & Simulat Ctr Excellence, Riga Tech Univ, MISS Lativan Ctr, LOGISIM, Lab Sci Informat Syst, Movimento Italiano Modellazione Simulazione, Univ Perugia, McLeod Inst SImulat Sci, McLeod Inst SImulat Sci, Brasilian Ctr, LAMCE COPPE UFRJ, McLeod Inst SImulat Sci, Mcleod Modeling & Simulat Network, Lativan Simulat Soc, Ecole Super Ingn Sci Appliquees, Fac Ciencia Exactas Ingn Agrimensura, Univ Laguna, CIFASIS CONICET UNR UPCAM, Inst Syst & Technologies Informat Control & Commun DE adaptive training; predictive modeling; intelligent tutoring systems; computer-based tutoring AB Researchers continue to enhance individual computer-based training capabilities to support self-directed learning and account for individual differences (e.g., personality or domain competence). Student-centric tutoring approaches recognize that each student's unique affect, motivation, skills, knowledge, preferences and experiences should influence the content, flow and challenge level of computer-based instruction. In other words, these individual differences should be the basis for adapting instruction to promote learning and predicting the future learning states of the student. This article explores current trends in adaptive and predictive computer-based tutoring methods, identifies gaps and discusses opportunities for future research. The intent of this paper is to introduce concepts discussed in the "adaptive and predictive computer-based tutoring" track of the the Defense and Homeland Security Simulation (DHSS) Workshop 2011. C1 [Sottilare, Robert A.] US Army, Res Lab, LITE Lab, Human Res & Engn Directorate, Adelphi, MD 20783 USA. [Goldberg, Stephen; Durlach, Paula] US Army, Res Lab, Adelphi, MD USA. RP Sottilare, RA (reprint author), US Army, Res Lab, LITE Lab, Human Res & Engn Directorate, Adelphi, MD 20783 USA. EM robert.sottilare@us.army.mil; stephen.goldberg@us.army.mil; paula.durlach@us.army.mil NR 12 TC 0 Z9 0 U1 0 U2 0 PU DIPTEM UNIV GENOA PI GENOA PA VIA OPERA OUA 15, GENOA, 16145, ITALY BN 978-88-903724-3-8 PY 2011 BP 91 EP 96 PG 6 WC Operations Research & Management Science SC Operations Research & Management Science GA BG8PN UT WOS:000392603200014 ER PT J AU Hunter, DR Stewart, JE AF Hunter, David R. Stewart, John E. TI Hazardous Events and Accident Involvement by Military and Civilian Pilots SO INTERNATIONAL JOURNAL OF AVIATION PSYCHOLOGY LA English DT Article ID INDICATORS; SAFETY AB The Hazardous Events Scale (HES), a measure of involvement in potentially dangerous situations in aviation that do not lead to accidents, has been used as a surrogate for actual accident involvement in studies of risk taking and hazardous attitudes. However, no correlation between the HES and actual accident involvement has previously been published. In this research effort we developed an Army-specific version of the HES and administered it, over the course of 4 separate surveys, to a large sample of U.S. Army aviators. We then computed Army-HES scores that we correlated with self-reported accident involvement. We also reanalyzed data from 4 separate civilian studies in which the civilian version of the HES was administered to compute a correlation between HES and self-reported accident involvement. We hypothesized that a positive correlation would be obtained between the HES and accident involvement. That hypothesis was supported by the results. Positive, significant correlations were obtained for the Army sample (r = .15), and each of the 4 civilian studies (r = .23, r = .32, r = .24, r = .30) between the HES and self-reported accident involvement. The use of the HES as a surrogate measure for accident involvement and indicator of pilot accident risk for both individual pilots and organizations is discussed. C1 [Hunter, David R.] Independent Counsultant, Fredericksburg, VA USA. [Stewart, John E.] USA, Res Inst Behav & Social Sci, Ft Rucker, AL USA. RP Hunter, DR (reprint author), 4308 Bridlepath Court, Fredericksburg, VA 22408 USA. EM david.hunter@avhf.com NR 15 TC 3 Z9 3 U1 1 U2 3 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1050-8414 J9 INT J AVIAT PSYCHOL JI Int. J. Aviat. Psychol. PY 2011 VL 21 IS 2 BP 123 EP 134 AR PII 935841750 DI 10.1080/10508414.2011.556451 PG 12 WC Psychology, Applied SC Psychology GA 746MJ UT WOS:000289250800002 ER PT J AU Bantum, E Kim, J Pulido, J Kirchhoff, M Nishimoto, P AF Bantum, Erin Kim, John Pulido, Janell Kirchhoff, Maureen Nishimoto, Pat TI Employing Content Analysis to Understand the Outcome of Expressive Arts on the Oncology Experience SO INTERNATIONAL JOURNAL OF QUALITATIVE METHODS LA English DT Meeting Abstract C1 [Bantum, Erin] Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA. [Kim, John; Pulido, Janell; Kirchhoff, Maureen; Nishimoto, Pat] Tripler Army Med Ctr, Honolulu, HI USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU UNIV ALBERTA, INT INST QUALITATIVE METHODOLOGY PI EDMONTON PA 5-217, EDMONTON CLINIC HEALTH ACAD, 11405 87 AVENUE, EDMONTON, AB T6G 1C9, CANADA SN 1609-4069 J9 INT J QUAL METH JI Int. J. Qual. Meth. PY 2011 VL 10 IS 4 BP 467 EP 467 PG 1 WC Social Sciences, Interdisciplinary SC Social Sciences - Other Topics GA 059ZL UT WOS:000312744200038 ER PT J AU Kwon, H Rauss, P AF Kwon, Heesung Rauss, Patrick TI Feature-based ensemble learning for hyperspectral chemical plume detection SO INTERNATIONAL JOURNAL OF REMOTE SENSING LA English DT Article ID RECOGNITION; ALGORITHM AB Feature-based ensemble learning, where weak hypotheses are learned within the associated feature subspaces constructed by repeated random feature selection, is described. The proposed ensemble approach is less affected by noisy features or outliers unique to the training set than the bagging and boosting algorithms due to the randomized selection of feature subsets from the entire training set. The individual weak hypotheses perform their own generalization processes, within the associated feature subspaces, independently of each other. This allows the proposed ensemble to provide improved performance on unseen data over other ensemble learning methods that randomly choose subsets of training samples in an input space. The weak hypotheses are combined through three different aggregating strategies: majority voting, weighted average and neural network-based aggregation. The proposed ensemble technique has been applied to hyperspectral chemical plume data and a performance comparison of the proposed and other existing ensemble methods is presented. C1 [Kwon, Heesung; Rauss, Patrick] USA, Res Lab, Adelphi, MD 20783 USA. RP Kwon, H (reprint author), USA, Res Lab, ATTN RDRL SES E 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM heesung.kwon@us.army.mil RI Rauss, Patrick/A-3029-2011 NR 28 TC 4 Z9 4 U1 1 U2 2 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0143-1161 J9 INT J REMOTE SENS JI Int. J. Remote Sens. PY 2011 VL 32 IS 21 BP 6631 EP 6652 DI 10.1080/01431161.2010.512937 PG 22 WC Remote Sensing; Imaging Science & Photographic Technology SC Remote Sensing; Imaging Science & Photographic Technology GA 866HI UT WOS:000298370800039 ER PT J AU Vecherin, SN Wilson, DK Pettit, CL AF Vecherin, Sergey N. Wilson, D. Keith Pettit, Chris L. TI Optimal sensor placement with signal propagation effects and inhomogeneous coverage preferences SO INTERNATIONAL JOURNAL OF SENSOR NETWORKS LA English DT Article DE binary linear programming; optimal sensor configuration; sensor placement; sensor networks; sensor location optimisation; distributed sensor networks ID APPROXIMATION ALGORITHMS; SET COVER AB The optimal sensor placement problem consists of determining the number, types, and locations of sensors satisfying inhomogeneous coverage requirements while minimising a specified cost function. The cost function can reflect various factors such as the actual cost of the sensors, their total number, and energy consumption. A strict and general formulation of the problem is described here for sensors characterised by probability of detection at some specified probability of false alarm. The formulation includes non-uniform coverage preferences and realistic, non-line-of-sight detection accounting on signal propagation effects. The optimisation is expressed as a solution to a binary linear programming problem. While exact solution of this problem is typically prohibitive, a fast greedy algorithm is presented that yields a near-optimal solution. It can also be successfully applied to improve coverage of an existing sensor network. This approach compares very favourably to an alternative heuristic strategy based on placing sensors one-by-one in the previously worst-covered location. C1 [Vecherin, Sergey N.; Wilson, D. Keith] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Pettit, Chris L.] USN Acad, Dept Aerosp Engn, Annapolis, MD 21402 USA. RP Vecherin, SN (reprint author), USA, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Sergey.N.Vecherin@usace.army.mil; D.Keith.Wilson@usace.army.mil; pettitcl@usna.edu RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 FU Engineer Research and Development Center (ERDC); Oak Ridge Institute for Science and Education (ORISE) FX This work was supported by the Engineer Research and Development Center (ERDC) Environmental Awareness for Sensor Employment (EASE) project. Dr. Vecherin's work was performed under a postgraduate fellowship appointment administrated by the Oak Ridge Institute for Science and Education (ORISE). NR 19 TC 10 Z9 10 U1 1 U2 5 PU INDERSCIENCE ENTERPRISES LTD PI GENEVA PA WORLD TRADE CENTER BLDG, 29 ROUTE DE PRE-BOIS, CASE POSTALE 896, CH-1215 GENEVA, SWITZERLAND SN 1748-1279 J9 INT J SENS NETW JI Int. J. Sens. Netw. PY 2011 VL 9 IS 2 BP 107 EP 120 DI 10.1504/IJSNET.2011.038763 PG 14 WC Computer Science, Information Systems; Telecommunications SC Computer Science; Telecommunications GA 743KK UT WOS:000289017000005 ER PT J AU Bliese, PD Thomas, JL McGurk, D McBride, S Castro, CA AF Bliese, Paul D. Thomas, Jeffrey L. McGurk, Dennis McBride, Sharon Castro, Carl A. TI Mental health advisory teams: A proactive examination of mental health during combat deployments SO INTERNATIONAL REVIEW OF PSYCHIATRY LA English DT Article ID MILITARY; IRAQ AB Mental health advisory teams (MHATs) conduct comprehensive mental health surveillance of US service members in combat environments. Since 2003, six teams have deployed to Iraq and four have deployed to Afghanistan, and results have played a key role influencing behavioural health policy. The repeated deployments of the teams have provided opportunities for processes to be refined, and this refinement has led to a scientifically rigorous and replicable approach. In this article we focus on two themes. The first theme is how changes in sampling have influenced the nature of the inferences drawn from the survey-based surveillance data. The second theme is how the ability to utilize different forms of data has served to strengthen the programme. Focusing on these two themes provides a way to discuss key findings, recommendations and limitations while also interspersing practical observations intended to help inform the design of broad-scale, in-theatre mental health surveillance efforts. We believe that future surveillance efforts should build on the lessons of the MHATs and attempt to replicate the more rigorous sampling methods; nonetheless, we also strive to convey that large surveillance efforts are valuable even if they cannot be executed with random sampling. C1 [Bliese, Paul D.; Thomas, Jeffrey L.; McGurk, Dennis] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [McBride, Sharon] Comprehens Soldier Fitness, Crystal City, VA USA. [Castro, Carl A.] USA, Med Res & Mat Command, Frederick, MD USA. RP Bliese, PD (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM paul.bliese@us.army.mil NR 13 TC 11 Z9 11 U1 0 U2 3 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0954-0261 J9 INT REV PSYCHIATR JI Int. Rev. Psych. PY 2011 VL 23 IS 2 BP 127 EP 134 DI 10.3109/09540261.2011.558834 PG 8 WC Psychiatry SC Psychiatry GA 755PO UT WOS:000289946800002 PM 21521081 ER PT J AU Wells, TS Miller, SC Adler, AB Engel, CC Smith, TC Fairbank, JA AF Wells, Timothy S. Miller, Shannon C. Adler, Amy B. Engel, Charles C. Smith, Tyler C. Fairbank, John A. TI Mental health impact of the Iraq and Afghanistan conflicts: A review of US research, service provision, and programmatic responses SO INTERNATIONAL REVIEW OF PSYCHIATRY LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; TRAUMATIC BRAIN-INJURY; SOCIAL ANXIETY DISORDER; NATIONAL-GUARD SOLDIERS; WAR VETERANS; PRIMARY-CARE; COMBAT DEPLOYMENT; D-CYCLOSERINE; LONGITUDINAL ASSESSMENT; MILITARY PERSONNEL AB Although documentation that war inflicts psychological casualties dates back to the American Civil War and earlier, most research began after the Vietnam conflict, when studies focused on post-traumatic stress disorder (PTSD). With ongoing conflicts in Iraq and Afghanistan, there has been significant research to illuminate the epidemiology of war-related psychological casualties. Significant findings include an appreciation for the role combat plays in the development of mental disorders, including PTSD and traumatic brain injury (TBI). Recent research has endeavoured to understand and improve psychological resilience to temper potentially adverse mental health effects of military service in the theatre of combat operations. Over 2 million US service members have now deployed and returned over 3 million times to the Iraq and Afghanistan conflicts. Mental health providers in the Departments of Defense and Veterans Affairs healthcare systems have consequently observed steep increases in mental health service use among these personnel. The Departments have responded aggressively to bolster staffing levels, increase capacity, improve available services, and anticipate future needs. Scientists and clinicians continue efforts to understand the determinants, prevention, recognition, and treatment of combat-related mental disorders. C1 [Wells, Timothy S.; Smith, Tyler C.] USN, Ctr Deployment Hlth Res, Hlth Res Ctr, San Diego, CA 92106 USA. [Miller, Shannon C.] USAF, Vulnerabil Anal Branch, Res Lab, Wright Patterson AFB, OH 45433 USA. [Miller, Shannon C.] Vet Affairs Med Ctr, Cincinnati, OH 45267 USA. [Miller, Shannon C.] Univ Cincinnati, Dept Psychiat & Behav Neurosci, Ctr Treatment Res & Educ Addict Disorders, Cincinnati, OH USA. [Adler, Amy B.] USA, Med Res Unit Europe, Walter Reed Army Inst Res, Heidelberg, Germany. [Engel, Charles C.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD USA. [Engel, Charles C.] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Deployment Hlth Clin Ctr, Washington, DC 20307 USA. [Fairbank, John A.] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC USA. [Fairbank, John A.] Mid Atlantic VISN 6 Mental Illness Res Educ & Cli, Durham, NC USA. RP Wells, TS (reprint author), USN, Ctr Deployment Hlth Res, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. EM timothy.wells@med.navy.mil RI Fairbank, John/F-8972-2013; Schueter, nicos/A-3625-2014 OI Fairbank, John/0000-0003-2604-7256; NR 91 TC 40 Z9 41 U1 4 U2 21 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0954-0261 J9 INT REV PSYCHIATR JI Int. Rev. Psych. PY 2011 VL 23 IS 2 BP 144 EP 152 DI 10.3109/09540261.2011.558833 PG 9 WC Psychiatry SC Psychiatry GA 755PO UT WOS:000289946800004 PM 21521083 ER PT S AU Getsinger, KD Netherland, MD Stubbs, DR AF Getsinger, Kurt D. Netherland, Mike D. Stubbs, Don R. BE Leslie, AR Westbrooks, RG TI Aquatic Herbicide Registration New Model SO INVASIVE PLANT MANAGEMENT ISSUES AND CHALLENGES IN THE UNITED STATES: 2011 OVERVIEW SE ACS Symposium Series LA English DT Article; Book Chapter AB Over the past several decades, aquatic herbicides have served as the major management tool for aquatic weeds in the United States. However, until 2001, only six active ingredients had been given national Environmental Protection Agency (EPA) Section Three aquatic registrations. Between 1977 and 2001, only two of these herbicides received EPA Section Three labels. The discovery of fluridone resistant hydrilla in the southeastern United States showed the need for a more diverse pool of chemicals to help minimize the development of herbicide resistance, and indicated the need for a more streamlined aquatic herbicide registration process. To meet this need, the chemical industry, the research community and the EPA formed a Federal Aquatic Herbicide Working group to assist in the registration of minor use aquatic herbicides. As a result of this new level of cooperation between industry, researchers, and federal regulators, a number of new aquatic herbicides have been registered in the past several years. In addition, there is a broader understanding of the need for aquatic herbicide registration, as well as their responsible use in the field. C1 [Getsinger, Kurt D.; Netherland, Mike D.] USA, Engineer Res & Dev Ctr, Vicksburg, MS USA. [Stubbs, Don R.] US EPA, Washington, DC 20460 USA. RP Getsinger, KD (reprint author), USA, Engineer Res & Dev Ctr, Vicksburg, MS USA. EM getsink@wes.army.mil NR 4 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA SN 0097-6156 BN 978-0-8412-7449-5 J9 ACS SYM SER JI ACS Symp. Ser. PY 2011 VL 1073 BP 45 EP 50 D2 10.1021/bk-2011-1073 PG 6 WC Plant Sciences SC Plant Sciences GA BDD83 UT WOS:000312876700007 ER PT J AU Lande, RG Marin, B Chang, AS AF Lande, R. Gregory Marin, Barbara Chang, Audrey S. TI Clinical Application of Ethyl Glucuronide Testing in the U.S. Army SO JOURNAL OF ADDICTIVE DISEASES LA English DT Article DE Biomarker; military; screening; monitoring ID POSTTRAUMATIC-STRESS-DISORDER; DIRECT ETHANOL METABOLITES; ALCOHOL-USE; CONSUMPTION; BIOMARKER; VETERANS; SULFATE; MARKER; WAR AB This study examined the clinical characteristics of ethyl glucuronide testing among service members referred to a military substance abuse program. The authors analyzed 1,852 urine specimens from 328 service members collected over a two year period. Among all participants, approximately one-fifth (n = 45/262, 17.2%) produced a positive ethyl glucuronide result at the initial assessment. Nearly two-thirds (n = 29/45, 64%) of the service members who initially tested positive had at least one additional positive specimen during the next five sequential tests. A statistically significant decline (p = 0.017) in ethyl glucuronide levels occurred with serial testing over time. The authors suggest that ethyl glucuronide testing can join with other risk mitigation strategies to help reduce alcohol-related adverse incidents. C1 [Lande, R. Gregory; Marin, Barbara; Chang, Audrey S.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Lande, RG (reprint author), 13826 Bison Court, Silver Spring, MD 20906 USA. EM rglande@act85.com NR 23 TC 2 Z9 2 U1 0 U2 1 PU HAWORTH PRESS INC PI BINGHAMTON PA 10 ALICE ST, BINGHAMTON, NY 13904-1580 USA SN 1055-0887 J9 J ADDICT DIS JI J. Addict. Dis. PY 2011 VL 30 IS 1 BP 39 EP 44 AR PII 931973527 DI 10.1080/10550887.2010.531664 PG 6 WC Substance Abuse SC Substance Abuse GA 714NM UT WOS:000286816300005 PM 21218309 ER PT J AU Russell, K Shen, J AF Russell, Kevin Shen, John TI Planar Four-Bar Motion and Path Generation with Order and Branching Conditions SO JOURNAL OF ADVANCED MECHANICAL DESIGN SYSTEMS AND MANUFACTURING LA English DT Article DE Four-Bar Linkage; Optimization; Motion Generation; Path Generation ID MECHANISM DESIGN AB This work presents an optimization model for planar four-bar motion and path generation. This model includes the four-bar linkage kinematic model by Suh and Radcliffe((13)) as an objective function. This kinematic model allows for the direct minimization of the error between the prescribed and achieved coupler parameters while synthesizing the crank and follower links in a closed loop. Both order and branching conditions are included among the constraint equations. C1 [Russell, Kevin] USA, Res Dev & Engn Ctr, Armaments Engn & Technol Ctr, Picatinny Arsenal, NJ 07806 USA. [Shen, John] ASCO Power Technol, Power Control Syst Engn, Florham Pk, NJ 07932 USA. RP Russell, K (reprint author), USA, Res Dev & Engn Ctr, Armaments Engn & Technol Ctr, Picatinny Arsenal, NJ 07806 USA. EM kevin.russell1@us.army.mil NR 15 TC 4 Z9 4 U1 2 U2 3 PU JAPAN SOC MECHANICAL ENGINEERS PI TOKYO PA SHINANOMACHI-RENGAKAN BLDG., SHINANOMACHI 35, SHINJUKU-KU, TOKYO, 160-0016, JAPAN SN 1881-3054 J9 J ADV MECH DES SYST JI J. Adv. Mech. Des. Syst. Manuf. PY 2011 VL 5 IS 4 BP 264 EP 273 DI 10.1299/jamdsm.5.264 PG 10 WC Engineering, Manufacturing; Engineering, Mechanical SC Engineering GA 874ML UT WOS:000298962300004 ER PT J AU Fresconi, F Cooper, G Costello, M AF Fresconi, Frank Cooper, Gene Costello, Mark TI Practical Assessment of Real-Time Impact Point Estimators for Smart Weapons SO JOURNAL OF AEROSPACE ENGINEERING LA English DT Article DE Impact point predictors; Monte Carlo; Model error AB There are numerous ways to estimate the trajectory and subsequent impact point of a projectile. Some complex methods are highly accurate and require a lot of input data while others are fairly trivial and less accurate but require minimal input data. Projectile impact point predictors (IPPs) have three primary error sources: model error, parameter error, and initial state error. While model error typically shrinks as model complexity increases, parameter and initial state errors grow with increasing model complexity. Since all input data feeding an IPP are uncertain to some level, the ideal IPP for an overall situation is not clear cut by any means. This paper examines several different projectile IPPs that span the range of complex nonlinear rigid projectile models to simple vacuum point mass models with the intent to better understand relative merits of each algorithm in relation to the other algorithms and as a function of parameter uncertainty and initial state error. Monte Carlo simulation is employed to compute impact point statistics as a function of the range to the target for an indirect fire 155-mm spin stabilized round. For this specific scenario, results indicated neglecting physical phenomena in the formulation of the equations of motion can degrade impact point prediction, especially early in the flight. Adding uncertainty to the parameters and states induces impact point errors that dominate model error contributions. Impact point prediction errors scaled linearly with parameter and state errors. All IPPs investigated converged to the actual impact point as the time at which the estimate took place approached the time of impact. C1 [Fresconi, Frank; Cooper, Gene] USA, Res Lab, Aerodynam Branch, Aberdeen Proving Ground, MD 21005 USA. [Costello, Mark] Georgia Inst Technol, Sch Aerosp Engn, Atlanta, GA 30332 USA. RP Cooper, G (reprint author), USA, Res Lab, Aerodynam Branch, Aberdeen Proving Ground, MD 21005 USA. NR 5 TC 14 Z9 16 U1 2 U2 8 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0893-1321 J9 J AEROSPACE ENG JI J. Aerosp. Eng. PD JAN PY 2011 VL 24 IS 1 BP 1 EP 11 DI 10.1061/(ASCE)AS.1943-5525.0000044 PG 11 WC Engineering, Aerospace; Engineering, Civil SC Engineering GA 695IV UT WOS:000285364700001 ER PT J AU Clayton, JD AF Clayton, J. D. TI A Nonlinear Thermomechanical Model of Spinel Ceramics Applied to Aluminum Oxynitride (AlON) SO JOURNAL OF APPLIED MECHANICS-TRANSACTIONS OF THE ASME LA English DT Article DE elasticity; plasticity; shock physics; ceramics; minerals; AlON ID COMPRESSIVE FAILURE; CRYSTAL PLASTICITY; DYNAMIC PLASTICITY; SINGLE-CRYSTALS; BRITTLE SOLIDS; SHOCK-WAVE; DEFORMATION; FRACTURE; SAPPHIRE; FRAGMENTATION AB A continuum model is developed for describing deformation and failure mechanisms in crystalline solids (ceramics and minerals) with the cubic spinel structure. The constitutive model describes the response under conditions pertinent to impact loading: high pressures, high strain rates, and, possibly, high temperatures. Nonlinear elasticity, anisotropy, thermoelastic coupling, dislocation glide, twinning, shear-induced fracture, and pressure-induced pore collapse are addressed. The model is applied to enable an improved understanding of transparent ceramic aluminum oxynitride (AlON). Calculations demonstrate an accurate depiction of hydrostatic and shear stresses observed experimentally in shock-loaded polycrystalline AlON. Various choices of initial resistances to slip, twinning, or shear fracture that result in similar predictions for average stresses in polycrystals but different predictions for defect densities (accumulated dislocations and twin volume fractions) are investigated. Predictions for single crystals provide insight into grain orientation effects not available from previous experimental investigations. [DOI: 10.1115/1.4002434] C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Clayton, JD (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM jclayton@arl.army.mil RI Clayton, John/C-7760-2009 NR 56 TC 12 Z9 12 U1 2 U2 16 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0021-8936 J9 J APPL MECH-T ASME JI J. Appl. Mech.-Trans. ASME PD JAN PY 2011 VL 78 IS 1 AR 011013 DI 10.1115/1.4002434 PG 11 WC Mechanics SC Mechanics GA 674KC UT WOS:000283739400013 ER PT J AU Cochrane, CJ Lenahan, PM Lelis, AJ AF Cochrane, C. J. Lenahan, P. M. Lelis, A. J. TI An electrically detected magnetic resonance study of performance limiting defects in SiC metal oxide semiconductor field effect transistors SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID SPIN-DEPENDENT RECOMBINATION; SURFACE RECOMBINATION; SILICON; HYDROGEN; CENTERS; TECHNOLOGY; RADIATION; 4H AB In this study, we utilize electrically detected magnetic resonance (EDMR) techniques and electrical measurements to study defects in SiC based metal oxide semiconductor field effect transistors (MOSFETs). We compare results on a series of SiC MOSFETs prepared with significantly different processing parameters. The EDMR is detected through spin dependent recombination (SDR) in most cases. However, in some devices at a fairly high negative bias, the EDMR likely also involves spin dependent trap-assisted tunneling (SDT) between defects on both sides of the SiC/SiO2 interface. At least three different defects have been detected in the magnetic resonance measurements. The defects observed include two at the SiC/SiO2 interface or on the SiC side of the SiC/SiO2 interface: one is very likely a vacancy center with a distribution which extends into the bulk of the SiC and the other is likely a "dangling bond" defect. A third defect, located on the SiO2 side of the SiC/SiO2 interface, has a spectrum very similar to that previously reported for an oxygen deficient silicon coupled to a hydrogen atom. In nearly all cases, we observe a strong dominating single line EDMR spectrum with an isotropic g approximate to 2.0027. In some samples, this strong central line is accompanied by two pairs of considerably weaker side peaks which we link to hyperfine interactions with nearby Si and C atoms. The pattern is physically reasonable for a silicon vacancy in SiC. We therefore tentatively assign it to a silicon vacancy or silicon vacancy associated defect in the SiC. In one set of devices with very high interface trap density we observe another dominating spectrum with g(parallel to)=2.0026 and g(perpendicular to)=2.0010 with the symmetry axis coincident with the [0001] and nearly the SiC/SiO2 interface normal. We ascribe this EDMR spectrum to a "dangling bond" defect. A third EDMR spectrum shows up in some devices at a fairly large negative gate bias. The phase of this spectrum is quite consistently opposite to that of the SDR detected EDMR at other biases. Part of this inverted phase spectrum involves two narrow lines which are separated by approximate to 10.5 G. Since the center responsible for this spectrum is almost certainly in the SiO2, it is likely due to the so called 10.4 G doublet center, an unpaired electron residing on an oxygen deficient silicon atom coupled to a hydrogen in SiO2. The likely presence of one oxygen deficient silicon defect suggests that other oxygen deficient silicon atom defect sites in the oxide may also be important in SiC/SiO2 devices. Oxygen deficient silicon defects in SiO2 are typically called E' centers. Our results collectively demonstrate considerable complexity in both the chemical composition and physical distribution of performance limiting defects in SiC transistors, with defects observed on both sides of the SiC/SiO2 interface. Our results most strongly indicate that fairly high densities of intrinsic deep-level defects, likely due to a Si vacancy or a closely related defect, extend into the bulk of the SiC in all but one of the devices prepared utilizing a fairly wide range of processing parameters. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3530600] C1 [Cochrane, C. J.; Lenahan, P. M.] Penn State Univ, University Pk, PA 16802 USA. [Lelis, A. J.] USA, Res Lab, Adelphi, MD 20783 USA. RP Cochrane, CJ (reprint author), Penn State Univ, University Pk, PA 16802 USA. EM pmlesm@engr.psu.edu FU U.S. Army Research Laboratory FX This work at Pennsylvania State University was supported by the U.S. Army Research Laboratory. We thank D. Meyer and M. Dautrich for technical contributions to this study. NR 33 TC 30 Z9 30 U1 1 U2 31 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JAN 1 PY 2011 VL 109 IS 1 AR 014506 DI 10.1063/1.3530600 PG 12 WC Physics, Applied SC Physics GA 706LG UT WOS:000286219300138 ER PT J AU Dietrich, JP Boylen, DA Thompson, DE Loboschefsky, EJ Bravo, CF Spangenberg, DK Ylitalo, GM Collier, TK Fryer, DS Arkoosh, MR Loge, FJ AF Dietrich, Joseph P. Boylen, Deborah A. Thompson, Donald E. Loboschefsky, Erik J. Bravo, Claudia F. Spangenberg, Dina K. Ylitalo, Gina M. Collier, Tracy K. Fryer, Derek S. Arkoosh, Mary R. Loge, Frank J. TI An Evaluation of the Influence of Stock Origin and Out-migration History on the Disease Susceptibility and Survival of Juvenile Chinook Salmon SO JOURNAL OF AQUATIC ANIMAL HEALTH LA English DT Article ID SNAKE RIVER; DELAYED MORTALITY; HYDROPOWER SYSTEM; PACIFIC-NORTHWEST; COLUMBIA RIVERS; HATCHERY; STEELHEAD; WILD AB Various methods have been developed to mitigate the adverse effects of the Federal Columbia River Power System on juvenile Pacific salmon out-migrating through the Columbia River basin. In this study, we found that hatchery-reared spring Chinook salmon Oncorhynchus tshawytscha in the river are in varying degrees of health, which may affect delayed mortality and the assessment of the effectiveness of management actions to recover listed stocks (e. g., barging fish downstream versus leaving fish in the river). A laboratory disease challenge with Listonella anguillarum was completed on fish from Rapid River Hatchery and Dworshak National Fish Hatchery (NFH) with different out-migration histories: (1) transported by barge, (2) removed from the river before barging, or (3) left to travel in-river. Barged fish from Rapid River Hatchery experienced less mortality than fish from Dworshak NFH. No statistical differences were found between the hatcheries with fish that had in-river out-migration histories. We suggest that the stressors and low survival associated with out-migration through the hydropower system eliminated any differences that could have been present. However, 18-25% of the fish that were barged or collected before barging died in the laboratory before the disease challenge, compared with less than 2% of those that traveled in-river. Owing to disproportionate prechallenge mortality, the disease-challenged populations may have been biased; thus, they were also considered together with the prechallenge mortalities. The synthesis of prechallenge and disease-challenged mortalities and health characteristics evaluated during out-migration indicated that the benefit of barging was not consistent between the hatcheries. This finding agrees with adult survival and delayed mortality estimates for the individual hatcheries determined fromadult returns. The results suggest that the health status of fish and their history before entering the hydropower system (hatchery of origin and out-migration path) are critical variables affecting the conclusions drawn from studies that evaluate mitigation strategies. C1 [Dietrich, Joseph P.; Boylen, Deborah A.; Arkoosh, Mary R.] Natl Ocean & Atmospher Adm Fisheries, NW Fisheries Sci Ctr, Newport Res Stn, Newport, OR 97365 USA. [Thompson, Donald E.; Loboschefsky, Erik J.; Bravo, Claudia F.; Loge, Frank J.] Univ Calif Davis, Dept Civil & Environm Engn, Davis, CA 95616 USA. [Spangenberg, Dina K.; Ylitalo, Gina M.; Collier, Tracy K.] Natl Ocean & Atmospher Adm Fisheries, NW Fisheries Sci Ctr, Seattle, WA 98112 USA. [Fryer, Derek S.] USA, Corps Engnineers, Walla Walla, WA 99362 USA. RP Dietrich, JP (reprint author), Natl Ocean & Atmospher Adm Fisheries, NW Fisheries Sci Ctr, Newport Res Stn, 2032 SE OSU Dr, Newport, OR 97365 USA. EM joseph.dietrich@noaa.gov FU U.S. Army Corps of Engineers (USACE); NOAA Fisheries Service FX Funding for this study was provided, in part, by the Anadromous Fish Evaluation Program of the U.S. Army Corps of Engineers (USACE) and NOAA Fisheries Service. Hatchery fish were tagged by Biomark (Scott McCutcheon, Boise, Idaho) and provided by Idaho Fish and Game (IDFG; Sharon Keifer and Ralph Steiner) and U.S. Fish and Wildlife Service (USFWS; Ralph Roseburg). Programming of the PIT tag separation-by-code functions was provided by Dave Marvin, Pacific States Marine Fisheries Commission. The transport tank and assistance were provided by Scott Davidson (NOAA). Assistance in collection and facilities were provided, in part, by Kent Blevins (USACE), Mike Halter (USACE), Doug Marsh (NOAA), Fred Mensik (Smolt Monitoring Program), and Neil Paasch (NOAA) at Lower Granite Dam; Dean Ballinger (Pacific States Marine Fisheries Commission), Jonathan Rerecich (USACE), Timothy Darland (USACE), and Lyle Gilbreath (NOAA) at Bonneville Dam; and Miro Zyndol (USACE) and Terry Hurd (USACE) at the Dalles Dam. Assistance in pathology review was provided by Doug Munson (IDFG), Leslie Lindsay, John Kaufman, and Tony Amandi (Fish Health Section, ODFW), and Kathy Clemens (USFWS). We appreciate the lipid analyses conducted by Daryle Boyd, Karen Tilbury, and Gladys Yanagida from the Northwest Fisheries Science Center. Special thanks are extended to the tugboat captains and crew for their assistance in transferring fish on and off the vessels, as well as Samantha Bund, Nancy Raskauskas, and Amber Roegner at NOAA Fisheries Service and University of California Davis for their assistance in fish transport and care. Finally, we appreciate the many insightful comments provided by Lyndal Johnson, John Ferguson, and Gene Matthews (NOAA). NR 34 TC 4 Z9 4 U1 1 U2 9 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0899-7659 J9 J AQUAT ANIM HEALTH JI J. Aquat. Anim. Health PY 2011 VL 23 IS 1 BP 35 EP 47 DI 10.1080/08997659.2011.568859 PG 13 WC Fisheries; Veterinary Sciences SC Fisheries; Veterinary Sciences GA 750TL UT WOS:000289570800005 PM 21699135 ER PT J AU Mcfarland, DG Shafer, DJ AF Mcfarland, Dwilette G. Shafer, D. J. TI Protocol considerations for aquatic plant seed bank assessment SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE emergence; extraction; restoration; seedling; separation; submersed vegetation ID BURIED WEED SEEDS; PRAIRIE GLACIAL MARSHES; VIABLE SEEDS; WATER REGIME; POTAMOGETON-PERFOLIATUS; ENVIRONMENTAL-FACTORS; VEGETATION DYNAMICS; LAKESHORE PLANTS; EMERGENCE METHOD; RUPPIA-MARITIMA AB Many procedures have been developed to assess seed bank characteristics, and most can be grouped into either of 2 categories: seedling emergence assays or seed separation from substrate. These procedures are particularly useful in predicting vegetation recurrence and determining need for restoration or control strategies through estimates of seed bank attributes (e.g., species composition, density, distribution, and viability). However, due to the lack of a standard protocol for seed bank investigations, researchers must select appropriate methods based on knowledge of different techniques and their potential to accomplish research goals. Here, we review a range of procedures for aquatic/wetland seed bank assessment with regard to difficulty in use, test reliability and accuracy, and laboratory resource (time, space, and labor) requirements. Information to improve sample collection and analysis is provided, and research to enhance seed/seedling identification and knowledge of germination requirements is advised. C1 [Mcfarland, Dwilette G.; Shafer, D. J.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Shafer, DJ (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Deborah.J.Shafer@usace.army.mil FU Submerged Aquatic Vegetation (SAV) Restoration Research Program FX The authors gratefully acknowledge Mses. Ruthie McCoy, Helen Ingram, and Deborah Carpenter, for their assistance in obtaining requested reference materials through the ERDC Library. Dr. Dian Smith and Ms. Chetta Owens provided valuable comments and suggestions in review of an earlier version of this manuscript. Dr. Dennis Brandon provided guidance on statistical issues. Funding support was provided by the Submerged Aquatic Vegetation (SAV) Restoration Research Program. Permission to publish this material was granted by the Chief of Engineers. NR 124 TC 5 Z9 5 U1 1 U2 17 PU AQUATIC PLANT MANAGEMENT SOC, INC PI LEHIGH ACRES PA PO BOX 1477, LEHIGH ACRES, FL 33970 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JAN PY 2011 VL 49 BP 9 EP 19 PG 11 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA 759ZI UT WOS:000290290000002 ER PT J AU Warfield, KL Olinger, GG AF Warfield, Kelly Lyn Olinger, Gene Garrard TI Protective Role of Cytotoxic T Lymphocytes in Filovirus Hemorrhagic Fever SO JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY LA English DT Review ID EBOLA-VIRUS INFECTION; INACTIVATED MARBURG VIRUS; EQUINE ENCEPHALITIS-VIRUS; NONHUMAN-PRIMATES; GUINEA-PIGS; POSTEXPOSURE PROTECTION; DENDRITIC CELLS; RHESUS-MONKEYS; MOUSE MODEL; CYNOMOLGUS MACAQUES AB Infection with many emerging viruses, such as the hemorrhagic fever disease caused by the filoviruses, Marburg (MARV), and Ebola virus (EBOV), leaves the host with a short timeframe in which to mouse a protective immune response. In lethal cases, uncontrolled viral replication and virus-induced immune dysregulation are too severe to overcome, and mortality is generally associated with a lack of notable immune responses. Vaccination studies in animals have demonstrated an association of IgG and neutralizing antibody responses against the protective glycoprotein antigen with survival from lethal challenge. More recently, studies in animal models of filovirus hemorrhagic fever have established that induction of a strong filovirus-specific cytotoxic T lymphocyte (CTL) response can facilitate complete viral clearance. In this review, we describe assays used to discover CTL responses after vaccination or live filovirus infection in both animal models and human clinical trials. Unfortunately, little data regarding CTL responses have been collected from infected human survivors, primarily due to the low frequency of disease and the inability to perform these studies in the field. Advancements in assays and technologies may allow these studies to occur during future outbreaks. C1 [Warfield, Kelly Lyn] Integrated Biotherapeut Inc, Vaccine Dev, Gaithersburg, MD 20878 USA. [Olinger, Gene Garrard] USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA. RP Warfield, KL (reprint author), Integrated Biotherapeut Inc, Vaccine Dev, 21 Firstfield Rd,Suite 100, Gaithersburg, MD 20878 USA. EM kelly@integratedbiotherapeutics.com OI Olinger, Gene/0000-0001-7338-0292 FU U.S. Army; Defense Threat Reduction Agency FX The authors thank Sabrina Stronsky for reference assistance and support. Dr. Olinger is supported by the U.S. Army and the Defense Threat Reduction Agency funding to develop assays for assessing protective responses following virus infection. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. NR 123 TC 10 Z9 10 U1 1 U2 6 PU HINDAWI PUBLISHING CORPORATION PI NEW YORK PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA SN 1110-7243 J9 J BIOMED BIOTECHNOL JI J. Biomed. Biotechnol. PY 2011 AR 984241 DI 10.1155/2011/984241 PG 13 WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Research & Experimental Medicine GA 871QM UT WOS:000298752800001 ER PT J AU McGhee, LL Slater, TM Garza, TH Fowler, M DeSocio, PA Maani, CV AF McGhee, Laura L. Slater, Terry M. Garza, Thomas H. Fowler, Marcie DeSocio, Peter A. Maani, Christopher V. TI The Relationship of Early Pain Scores and Posttraumatic Stress Disorder in Burned Soldiers SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID MUTUAL MAINTENANCE; SERVICE MEMBERS; SYMPTOMS; INJURY; COMBAT; PTSD; IRAQ; AFGHANISTAN; PREDICTORS; MORPHINE AB Early acute pain after injury has been linked to long-term patient outcomes, including the development of posttraumatic stress disorder (PTSD). Several studies have identified a negative correlation between early anesthetic/analgesic usage and subsequent development of PTSD. This retrospective study examined the relationship between early acute pain and severity of PTSD symptoms in soldiers with burn injuries. Of the soldiers injured in Overseas Contingency Operations who had pain scores recorded at admission to the Emergency Department, 113 had burn injuries. Of those transferred to the military burn center, 47 were screened for PTSD using the PTSD checklist-military (PCL-M) survey at least 1 month after injury. Soldiers with mild, moderate, and severe pain scores had similar Injury Severity Scores and TBSA burned (P = .339 and .570, respectively). However, there were significant differences in PCL-M scores between the mild and severe pain groups (P = .017). The pain levels positively correlated with the PCL-M score (rho = 0.41, P = .004) but not with injury severity markers (Injury Severity Score and TBSA). These data suggest that early acute pain may be related to increased PCL-M score and PTSD symptoms. The intensity of pain was not related to the injury severity, and these data also show no association between pain intensity and physiological measures, including blood pressure and heart rate. However, this is a small sample size, and many other factors likely influence PTSD development. Further study is necessary to explore the relationship between early acute pain and subsequent development of PTSD symptoms. (J Burn Care Res 2011;32:46-51) C1 [McGhee, Laura L.] USA, Inst Surg Res, Battlefield Pain Control Area, Ft Sam Houston, TX 78234 USA. RP McGhee, LL (reprint author), USA, Inst Surg Res, Battlefield Pain Control Area, 3400 Rawley E Chambers, Ft Sam Houston, TX 78234 USA. RI DeSocio, Peter/E-2970-2011 FU US Army Institute of Surgical Research Battlefield Pain Control Research Area FX Supported by US Army Institute of Surgical Research Battlefield Pain Control Research Area. NR 26 TC 18 Z9 18 U1 4 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X J9 J BURN CARE RES JI J. Burn Care Res. PD JAN-FEB PY 2011 VL 32 IS 1 BP 46 EP 51 DI 10.1097/BCR.0b013e318204b359 PG 6 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA 703QR UT WOS:000285996000013 PM 21131845 ER PT J AU Figer, A Nissan, A Shani, A Borovick, R Stiener, M Baras, M Freund, HR Sulkes, A Stojadinovic, A Peretz, T AF Figer, Arie Nissan, Aviram Shani, Adi Borovick, Riva Stiener, Mariana Baras, Mario Freund, Herbert R. Sulkes, Aaron Stojadinovic, Alexander Peretz, Tamar TI Mature Results of a Prospective Randomized Trial Comparing 5-Flourouracil with Leucovorin to 5-Flourouracil with Levamisole as Adjuvant Therapy of Stage II and III Colorectal Cancer-The Israel Cooperative Oncology Group (ICOG) Study SO JOURNAL OF CANCER LA English DT Article DE colorectal cancer; adjuvant chemotherapy; 5-fluorouracil; leucovorin; levamisole; survival AB Objective: Survival benefit with adjuvant therapy was shown in patients with Stage III colorectal cancer (CRC). This study evaluates long-term (10-year) outcome in patients with CRC randomly assigned to adjuvant 5-Fluorouracil/Leucovorin (5FU+LV) or 5-FU/Levamisole (5FU+LEV). Methods: Between 1990 and 1995, 398 patients with curatively resected Stage II-III CRC were randomly assigned to adjuvant 5FU+LV or 5FU+LEV for 12 months. Results: No difference was evident in 10-year relapse-free or overall survival between study groups. Grade III toxicity was similar between groups; however, neurotoxicity was significantly greater with 5FU+LEV (p=0.02) and gastrointestinal toxicity with 5FU+LV (p=0.03). Female patients treated with 5FU+LEV had improved overall survival. Conclusions: Adjuvant treatment of CRC is still based on leucovorin modulated fluorouracil. The long-term follow-up results of this trial indicate that the adjuvant treatment of Stage II-III CRC with 5FU+LV or 5FU+LEV is equally effective. The finding of improved survival in female subjects treated with 5FU+LEV warrants further study to determine if Levamisole is a better modulator of 5-FU than Leucovorin in this patient subset. C1 [Figer, Arie] Tel Aviv Sourasky Med Ctr, Dept Oncol, Tel Aviv, Israel. [Nissan, Aviram; Freund, Herbert R.] Hadassah Hebrew Univ Med Ctr, Dept Surg, Jerusalem, Israel. [Shani, Adi] Kaplan Med Ctr, Dept Oncol, Rehovot, Israel. [Borovick, Riva; Stiener, Mariana] Lin Oncol Ctr, Haifa, Israel. [Baras, Mario] Hadassah Hebrew Univ Med Ctr, Dept Biostat, Jerusalem, Israel. [Sulkes, Aaron] Rabin Med Ctr, Dept Oncol, Petah Tiqwa, Israel. [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Stojadinovic, Alexander] US Mil Canc Inst, Washington, DC USA. [Peretz, Tamar] Hadassah Hebrew Univ Med Ctr, Dept Oncol, Jerusalem, Israel. RP Nissan, A (reprint author), Hadassah Hebrew Univ Med Ctr, Dept Surg, POB 24035, Jerusalem, Israel. EM anissan@hadassah.org.il FU Israel Cancer Association (special grant) FX This work was supported in part by the Israel Cancer Association (special grant). NR 31 TC 0 Z9 1 U1 0 U2 0 PU IVYSPRING INT PUBL PI LAKE HAVEN PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA SN 1837-9664 J9 J CANCER JI J. Cancer PY 2011 VL 2 BP 177 EP 185 DI 10.7150/jca.2.177 PG 9 WC Oncology SC Oncology GA V28QM UT WOS:000208695300020 PM 21475636 ER PT J AU Stojadinovic, A Summers, TA Eberhardt, J Cerussi, A Grundfest, W Peterson, CM Brazaitis, M Krupinski, E Freeman, H AF Stojadinovic, Alexander Summers, Thomas A. Eberhardt, John Cerussi, Albert Grundfest, Warren Peterson, Charles M. Brazaitis, Michael Krupinski, Elizabeth Freeman, Harold TI Consensus Recommendations for Advancing Breast Cancer: Risk Identification and Screening in Ethnically Diverse Younger Women SO JOURNAL OF CANCER LA English DT Review DE breast cancer; screening; personalized medicine; mammography; Bayesian Belief Networks; machine learning; Gail model; risk assessment AB A need exists for a breast cancer risk identification paradigm that utilizes relevant demographic, clinical, and other readily obtainable patient-specific data in order to provide individualized cancer risk assessment, direct screening efforts, and detect breast cancer at an early disease stage in historically underserved populations, such as younger women (under age 40) and minority populations, who represent a disproportionate number of military beneficiaries. Recognizing this unique need for military beneficiaries, a consensus panel was convened by the USA TATRC to review available evidence for individualized breast cancer risk assessment and screening in young (< 40), ethnically diverse women with an overall goal of improving care for military beneficiaries. In the process of review and discussion, it was determined to publish our findings as the panel believes that our recommendations have the potential to reduce health disparities in risk assessment, health promotion, disease prevention, and early cancer detection within and in other underserved populations outside of the military. This paper aims to provide clinicians with an overview of the clinical factors, evidence and recommendations that are being used to advance risk assessment and screening for breast cancer in the military. C1 [Stojadinovic, Alexander] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Stojadinovic, Alexander] US Mil Canc Inst, Washington, DC USA. [Summers, Thomas A.] Walter Reed Army Med Ctr, Dept Pathol & Lab Serv, Washington, DC 20307 USA. [Eberhardt, John] DecisionQ Corp, Washington, DC USA. [Cerussi, Albert] Univ Calif Irvine, Irvine, CA USA. [Grundfest, Warren] Univ Calif Los Angeles, Los Angeles, CA USA. [Peterson, Charles M.; Brazaitis, Michael] Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. [Krupinski, Elizabeth] Univ Arizona, Dept Radiol, Tucson, AZ 85724 USA. [Freeman, Harold] Ralph Lauren Ctr Canc Care & Prevent, New York, NY USA. RP Stojadinovic, A (reprint author), Walter Reed Army Med Ctr, Dept Surg, Gen Surg Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM stojadinovicmd@gmail.com FU Henry M. Jackson Foundation for the Advancement of Military Medicine FX The authors wish to acknowledge Tiffany Felix for her invaluable assistance supported in part by the Henry M. Jackson Foundation for the Advancement of Military Medicine. We are grateful to the members and staff of the Telemedicine and Advanced Technology Research Center and the Henry M. Jackson Foundation for the Advancement of Military Medicine for their consistent support of this collaborative research effort. NR 91 TC 4 Z9 4 U1 0 U2 5 PU IVYSPRING INT PUBL PI LAKE HAVEN PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA SN 1837-9664 J9 J CANCER JI J. Cancer PY 2011 VL 2 BP 210 EP 227 DI 10.7150/jca.2.210 PG 18 WC Oncology SC Oncology GA V28QM UT WOS:000208695300025 PM 21509152 ER PT J AU Man, YG Izadjoo, M Song, GH Stojadinovic, A AF Man, Yan-gao Izadjoo, Mina Song, Guohong Stojadinovic, Alexander TI In Situ Malignant Transformation and Progenitor-Mediated Cell Budding: Two Different Pathways for Breast Ductal and Lobular Tumor Invasion SO JOURNAL OF CANCER LA English DT Article DE Breast cancer; Tumor invasion; Tumor metastasis; Malignant transformation; Tumor cell budding; Myoepithelial cells; Tumor microenvironment; Tumor stem cells; lymphocytes AB The human breast lobular and ductal structures and the derived tumors from these structures differ substantial in their morphology, microenvironment, biological presentation, functions, and clinical prognosis. Based on these differences, we have proposed that pre-invasive lobular tumors may progress to invasive lesions through "in situ malignant transformation", in which the entire myoepithelial cell layer within a given lobule or lobular clusters undergoes extensive degeneration and disruptions, which allows the entire epithelial cell population associated with these myoepithelial cell layers directly invade the stroma or vascular structures. In contrast, pre-invasive ductal tumors may invade the stroma or vascular structures through "progenitor-mediated cell budding", in which focal myoepithelial cell degeneration-induced aberrant leukocyte infiltration causes focal disruptions in the tumor capsules, which selectively favor monoclonal proliferation of the overlying tumor stem cells or a biologically more aggressive cell clone. Our current study attempted to provide more direct morphological and immunohistochemical data that are consistent with our hypotheses. C1 [Man, Yan-gao; Izadjoo, Mina] Armed Forces Inst Pathol, Washington, DC 20306 USA. [Man, Yan-gao; Izadjoo, Mina] Armed Forces Inst Pathol, Dept Infect & Parasit Dis Pathol, Amer Registry Pathol, Washington, DC 20306 USA. [Song, Guohong] Peking Univ, Canc Hosp & Inst, Dept Med Oncol, Beijing, Peoples R China. [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Man, YG (reprint author), Henry Jackson Fdn, Diagnost & Translat Res Ctr, 401 Profess Dr, Gaithersburg, MD 20879 USA. EM yman@hjfresearch.org FU Congressionally Directed Medical Research Programs [DAMD17-01-1-0129, DAMD17-01-1-0130, PC051308]; Susan G. Komen Breast Cancer Foundation [BCTR0706983]; AFIP/ARP joint research initiative projects [05AA]; US Military Cancer Institute [2008-02]; Henry M. Jackson Foundation [2008-02]; Ministry of Chinese Science and Technology Department [2006CB910505] FX This study was supported in part by grants DAMD17-01-1-0129, DAMD17-01-1-0130, PC051308 from Congressionally Directed Medical Research Programs, BCTR0706983 from The Susan G. Komen Breast Cancer Foundation, 05AA from AFIP/ARP joint research initiative projects, grant 2008-02 from US Military Cancer Institute and Henry M. Jackson Foundation, and 2006CB910505 from the Ministry of Chinese Science and Technology Department. NR 54 TC 1 Z9 1 U1 0 U2 0 PU IVYSPRING INT PUBL PI LAKE HAVEN PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA SN 1837-9664 J9 J CANCER JI J. Cancer PY 2011 VL 2 BP 401 EP 412 DI 10.7150/jca.2.401 PG 12 WC Oncology SC Oncology GA V28QM UT WOS:000208695300052 PM 21811518 ER PT J AU Man, YG Grinkemeyer, M Izadjoo, M Stojadinovic, A AF Man, Yan-gao Grinkemeyer, Michael Izadjoo, Mina Stojadinovic, Alexander TI Malignant Transformation and Stromal Invasion from Normal or Hyperplastic Tissues: True or False? SO JOURNAL OF CANCER LA English DT Editorial Material DE Malignant transformation; Tumor invasion; Sick lobe; Tumor microenvironment; Tumor capsule AB Carcinogenesis is believed to be a multi-step process, progressing sequentially from normal to hyperplastic, to in situ, and to invasive stages. A number of studies, however, have detected malignancy-associated alterations in normal or hyperplastic tissues. As the molecular profile and clinical features of these tissues have not been defined, the authors invited several well-recognized pathologist, oncologists, biologist, surgeons, and molecular biologist to offer their opinion on: (1) whether these tissues belong to a previously unrevealed malignant entity or focal alterations with no significant consequence? (2) whether these alterations are linked to early onset of cancer or cancer of unknown primary site, and (3) how to further define these lesions? C1 [Man, Yan-gao; Izadjoo, Mina] Henry Jackson Fdn, Diagnost & Translat Res Ctr, Gaithersburg, MD 20879 USA. [Grinkemeyer, Michael] Armed Forces Inst Pathol, Washington, DC 20306 USA. [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Man, YG (reprint author), Henry Jackson Fdn, Diagnost & Translat Res Ctr, 401 Profess Dr, Gaithersburg, MD 20879 USA. EM ymann@hjfresearch.org FU NCI NIH HHS [N02 PC051308] NR 55 TC 2 Z9 2 U1 1 U2 1 PU IVYSPRING INT PUBL PI LAKE HAVEN PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA SN 1837-9664 J9 J CANCER JI J. Cancer PY 2011 VL 2 BP 413 EP 424 DI 10.7150/jca.2.413 PG 12 WC Oncology SC Oncology GA V28QM UT WOS:000208695300053 PM 21811519 ER PT J AU Villines, TC Carbonaro, S Hulten, E AF Villines, Todd C. Carbonaro, Salvatore Hulten, Eddie TI Calcium scoring and chest pain: Is it dead on arrival? SO JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY LA English DT Article DE Coronary artery calcium; Chest pain AB Coronary artery calcium(CAC) scoring has been shown to be a measure of overall coronary artery disease (CAD) burden and is a well-validated screening test that significantly improves cardiovascular risk prediction in asymptomatic adults beyond that provided with standard risk factors. The absence of coronary artery calcification identifies persons at very low cardiovascular risk. Among symptomatic patients, calcium scans have been shown to have high sensitivity for the presence of obstructive CAD among stable, low-intermediate risk middle-aged adults. This has prompted many to advocate for the expanded use of calcium scanning as a diagnostic test in symptomatic patients to rapidly identify patients without CAD, serving as a filter for invasive coronary angiography or hospital admission or both. However, recent studies suggest that the negative predictive value of CAC scoring to exclude obstructive CAD may be significantly decreased among patients at higher pretest likelihood for obstructive CAD, consistent with Bayesian reasoning. In a point-counterpoint format, this article discusses several considerations and potential limitations to the widespread use of CAC to exclude obstructive CAD in symptomatic patients which include (1) the effect of pretest disease prevalence on test accuracy, (2) limited clinical efficiency due to low specificity for obstructive CAD and myocardial ischemia and high background prevalence of CAC in adults, (3) occurrence of CAC relatively late in the atherosclerotic process, (4) lack of association of CAC with vulnerable and culprit coronary artery lesions, and (5) interindividual and racial heterogeneity in the process of atherosclerosis calcification. Published by Elsevier Inc on behalf of Society of Cardiovascular Computed Tomography. C1 [Villines, Todd C.; Carbonaro, Salvatore; Hulten, Eddie] Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. RP Villines, TC (reprint author), Walter Reed Army Med Ctr, Serv Cardiol, Bldg 2,Room 4A-34A,6900 Georgia Ave,NW, Washington, DC 20307 USA. EM todd.villines@amedd.army.mil OI Hulten, Edward/0000-0001-9281-0032; Villines, Todd/0000-0003-2674-3702 NR 29 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1934-5925 J9 J CARDIOVASC COMPUT JI J. Cardiovasc. Comput. Tomogr. PD JAN-FEB PY 2011 VL 5 IS 1 BP 30 EP 34 DI 10.1016/j.jcct.2010.10.002 PG 5 WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical Imaging SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine & Medical Imaging GA V34CG UT WOS:000209063900005 PM 21067988 ER PT J AU Lettieri, CJ Paolino, N Eliasson, AH Shah, AA Holley, AB AF Lettieri, Christopher J. Paolino, Nathalie Eliasson, Arn H. Shah, Anita A. Holley, Aaron B. TI Comparison of Adjustable and Fixed Oral Appliances for the Treatment of Obstructive Sleep Apnea SO JOURNAL OF CLINICAL SLEEP MEDICINE LA English DT Article DE Oral appliance; mandibular advancement device; obstructive sleep apnea; efficacy ID POSITIVE AIRWAY PRESSURE; MANDIBULAR ADVANCEMENT DEVICES; DENTAL APPLIANCE; CONTROLLED-TRIAL; EFFICACY; CROSSOVER; HYPOPNEA; THERAPY; ADULTS AB Study Objectives: To compare the efficacy of adjustable and fixed oral appliances for the treatment of OSA. Methods: Retrospective review of consecutive patients with OSA treated with either adjustable or fixed oral appliances. Polysomnography was conducted before and during therapy. Effective treatment was defined as an apnea-hypopnea index (AHI) < 5 events/h or < 10 events/h with resolution of sleepiness (Epworth < 10). We compared efficacy rates between fixed and adjustable appliances and sought to identify factors associated with greater success. Results: We included 805 patients, 602 (74.8%) treated with an adjustable and 203 (25.2%) a fixed oral appliances. Among the cohort, 86.4% were men; mean age was 41.3 +/- 9.2 years. Mean AHI was 30.7 +/- 25.6, with 34.1% having mild (AHI 5-14.9), 29.2% moderate (AHI 15-29.9), and 36.8% severe (AHI >= 30) OSA. Successful therapy was significantly more common with adjustable appliances. Obstructive events were reduced to < 5/h in 56.8% with adjustable compared to 47.0% with fixed appliances (p = 0.02). Similarly, a reduction of events to < 10 with resolution of sleepiness occurred in 66.4% with adjustable appliances versus 44.9% with fixed appliances (p < 0.001). For both devices, success was more common in younger patients, with lower BMI and less severe disease. Conclusions: Adjustable devices produced greater reductions in obstructive events and were more likely to provide successful therapy, especially in moderate-severe OSA. Fixed appliances were effective in mild disease, but were less successful in those with higher AHIs. Given these findings, the baseline AHI should be considered when selecting the type of oral appliance. C1 [Lettieri, Christopher J.; Paolino, Nathalie] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. [Lettieri, Christopher J.; Eliasson, Arn H.; Shah, Anita A.; Holley, Aaron B.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD USA. RP Lettieri, CJ (reprint author), Walter Reed Army Med Ctr, Dept Med, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM christopher.lettieri@us.army.mil NR 36 TC 37 Z9 38 U1 0 U2 5 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 1550-9389 J9 J CLIN SLEEP MED JI J. Clin. Sleep Med. PY 2011 VL 7 IS 5 BP 439 EP 445 DI 10.5664/JCSM.1300 PG 7 WC Clinical Neurology SC Neurosciences & Neurology GA 836TF UT WOS:000296134600016 PM 22003337 ER PT J AU Balkin, TJ AF Balkin, Thomas J. TI Behavioral Biomarkers of Sleepiness SO JOURNAL OF CLINICAL SLEEP MEDICINE LA English DT Article ID REGIONAL BRAIN ACTIVITY; 24 H; DEPRIVATION; PERFORMANCE; RESTRICTION; ACCIDENTS; ALERTNESS; RECOVERY; PATTERNS; COST AB For those endeavoring to develop better methods of measuring/quantifying sleepiness, the "Holy Grail" is a measure that is maximally objective, completely unobtrusive, exquisitely sensitive, and absolutely specific (i.e., varies only as a function of sleepiness). By these criteria, physiological measures (e.g., based on brain activity such as EEG, fMRI, near-infrared spectroscopy, etc.) would appear to hold the most promise. However, from an operational standpoint, the utility of a sleepiness measure is derived not from its ability to sensitively reflect the brain's extant level of sleepiness per se, but from the implications that this level of sleepiness has for the individual's current and near-term ability to safely and efficiently perform operationally-relevant tasks. Thus, an ideal operationally-relevant sleepiness measure is one that is unobtrusively embedded in the actual operational task, and allows sleepiness-related performance deficits to be distinguished from performance deficits due to other causes. Toward this end, we have developed a PVT-derived metric that incorporates the entire distribution of responses within a PVT session, and reflects changes in the pattern of performance that can be used to identify and quantify "state instability"-the putative physiological state that specifically underlies sleepiness-induced performance deficits. C1 Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD 20910 USA. RP Balkin, TJ (reprint author), Walter Reed Army Inst Res, Dept Behav Biol, 503 Robert Grant Ave,Suite 2A26, Silver Spring, MD 20910 USA. EM thomas.balkin@us.army.mil FU NHLBI NIH HHS [R13 HL104874, HL104874] NR 23 TC 5 Z9 5 U1 1 U2 2 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 1550-9389 J9 J CLIN SLEEP MED JI J. Clin. Sleep Med. PY 2011 VL 7 IS 5 BP S12 EP S15 DI 10.5664/JCSM.1344 PG 4 WC Clinical Neurology SC Neurosciences & Neurology GA 836TF UT WOS:000296134600004 PM 22003322 ER PT J AU Mullington, JM Czeisler, CA Goel, N Krueger, JM Balkin, TJ Johns, M Shaw, PJ AF Mullington, Janet M. Czeisler, Charles A. Goel, Namni Krueger, James M. Balkin, Thomas J. Johns, Murray Shaw, Paul J. TI Panel Discussion: Current Status of Measuring Sleepiness SO JOURNAL OF CLINICAL SLEEP MEDICINE LA English DT Editorial Material C1 [Mullington, Janet M.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Neurol, Boston, MA 02215 USA. [Czeisler, Charles A.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Sleep Med, Boston, MA 02215 USA. [Goel, Namni] Univ Penn, Dept Psychiat, Perelman Sch Med, Div Sleep & Chronobiol, Philadelphia, PA 19104 USA. [Krueger, James M.] Washington State Univ, WWAMI Med Educ Program, Sleep & Performance Res Ctr, Spokane, WA USA. [Balkin, Thomas J.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD USA. [Johns, Murray] Optalert Pty Ltd, Epworth Sleep Ctr, Melbourne, Vic, Australia. [Shaw, Paul J.] Washington Univ, Dept Anat & Neurobiol, St Louis, MO USA. RP Mullington, JM (reprint author), Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Neurol, Boston, MA 02215 USA. FU NHLBI NIH HHS [HL104874, R13 HL104874] NR 0 TC 7 Z9 7 U1 0 U2 2 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 1550-9389 J9 J CLIN SLEEP MED JI J. Clin. Sleep Med. PY 2011 VL 7 IS 5 BP S22 EP S25 DI 10.5664/JCSM.1350 PG 4 WC Clinical Neurology SC Neurosciences & Neurology GA 836TF UT WOS:000296134600007 PM 22003325 ER PT J AU Gumz, JE AF Gumz, Jonathan E. TI Hitler's New Disorder: The Second World War in Yugoslavia SO JOURNAL OF CONTEMPORARY HISTORY LA English DT Book Review C1 [Gumz, Jonathan E.] US Mil Acad, West Point, NY 10996 USA. RP Gumz, JE (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0022-0094 J9 J CONTEMP HIST JI J. Contemp. Hist. PD JAN PY 2011 VL 46 IS 1 SI SI BP 219 EP 222 PG 4 WC History SC History GA 713HS UT WOS:000286727800020 ER PT J AU Gumz, JE AF Gumz, Jonathan E. TI Genocide and Resistance in Hitler's Bosnia: The Partisans and Chetniks, 1941-1943 SO JOURNAL OF CONTEMPORARY HISTORY LA English DT Book Review C1 [Gumz, Jonathan E.] US Mil Acad, West Point, NY 10996 USA. RP Gumz, JE (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0022-0094 J9 J CONTEMP HIST JI J. Contemp. Hist. PD JAN PY 2011 VL 46 IS 1 SI SI BP 219 EP 222 PG 4 WC History SC History GA 713HS UT WOS:000286727800019 ER PT J AU Tan, BH Barry, CI Wick, MR White, KP Brown, JG Lee, A Litchfield, AH Lener, EV Shitabata, PK AF Tan, Belinda H. Barry, Catherine I. Wick, Mark R. White, Kevin P. Brown, Jeffrey G. Lee, Abigail Litchfield, Amy H. Lener, Elizabeth V. Shitabata, Paul K. TI Multicentric reticulohistiocytosis and urologic carcinomas: a possible paraneoplastic association SO JOURNAL OF CUTANEOUS PATHOLOGY LA English DT Article ID LANGERHANS CELL HISTIOCYTOSIS; RHEUMATOID-ARTHRITIS SYNOVIUM; TRANSCRIPTION FACTOR-I; GENE-PRODUCTS; EXPRESSION; P53; INFLIXIMAB; APOPTOSIS AB Multicentric reticulohistiocytosis (MR) is a rare non-Langerhans histiocytosis that is characterized by cutaneous nodules and severe destructive arthritis. Although 25-30% of reported cases have been associated with internal malignancies, the pathophysiology of MR is unknown. Herein, we report two cases of MR that were associated with urologic neoplasms. Because the tumor suppressor gene p53 may play a role in the biology of other histiocytoses, we investigated its p53 immunoexpression in these two cases. Both cases were positive immunohistochemically, but it remains to be seen whether this finding is truly important in the pathogenesis of MR associated with underlying visceral neoplasms. C1 [Shitabata, Paul K.] Dermatopathol Inst, Torrance, CA 90503 USA. [Tan, Belinda H.; Shitabata, Paul K.] Harbor UCLA Med Ctr, Div Dermatol, Torrance, CA 90509 USA. [Barry, Catherine I.; Brown, Jeffrey G.] Cedars Sinai Med Ctr, Dept Pathol, Los Angeles, CA 90048 USA. [Wick, Mark R.] Univ Virginia, Dept Pathol, Charlottesville, VA 22903 USA. [White, Kevin P.] Oregon Hlth & Sci Univ, Dept Dermatol, Portland, OR 97201 USA. [Lee, Abigail] Walter Reed Army Med Ctr, Dept Dermatol, Washington, DC 20307 USA. [Lee, Abigail] Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. [Litchfield, Amy H.; Lener, Elizabeth V.] Dermatol Ctr, Ladera Ranch, CA USA. RP Shitabata, PK (reprint author), Dermatopathol Inst, 3870 Amo Blvd,Unit 507, Torrance, CA 90503 USA. EM dermpathmd@gmail.com NR 31 TC 10 Z9 10 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0303-6987 J9 J CUTAN PATHOL JI J. Cutan. Pathol. PD JAN PY 2011 VL 38 IS 1 BP 43 EP 48 DI 10.1111/j.1600-0560.2010.01608.x PG 6 WC Dermatology; Pathology SC Dermatology; Pathology GA 682AI UT WOS:000284367300009 PM 20726933 ER PT J AU Stearns, L AF Stearns, L. TI FATAL CASE OF CUTANEOUS RHIZOPUS SO JOURNAL OF CUTANEOUS PATHOLOGY LA English DT Meeting Abstract C1 [Stearns, L.] Walter Reed Army Med Ctr, Natl Capital Consortium, Burke, VA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0303-6987 J9 J CUTAN PATHOL JI J. Cutan. Pathol. PD JAN PY 2011 VL 38 IS 1 BP 97 EP 97 PG 1 WC Dermatology; Pathology SC Dermatology; Pathology GA 682AI UT WOS:000284367300079 ER PT J AU Cordero, SC Royer, M Rush, M Hallman, J Lupton, G AF Cordero, S. C. Royer, M. Rush, M. Hallman, J. Lupton, G. TI APOCRINE NEVUS: A REPORT OF THREE CASES SO JOURNAL OF CUTANEOUS PATHOLOGY LA English DT Meeting Abstract C1 [Cordero, S. C.; Royer, M.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Rush, M.; Hallman, J.; Lupton, G.] Armed Forces Inst Pathol, Washington, DC 20306 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0303-6987 J9 J CUTAN PATHOL JI J. Cutan. Pathol. PD JAN PY 2011 VL 38 IS 1 BP 135 EP 135 PG 1 WC Dermatology; Pathology SC Dermatology; Pathology GA 682AI UT WOS:000284367300237 ER PT J AU David, NV Gao, XL Zheng, JQ AF David, N. V. Gao, X. -L. Zheng, J. Q. TI Stress Relaxation of a Twaron (R)/Natural Rubber Composite SO JOURNAL OF ENGINEERING MATERIALS AND TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article DE ballistic fabrics; stress relaxation; viscoelasticity; relaxation modulus; relaxation time; Prony series; natural rubber; rheological model ID HIGH-STRAIN RATES; VISCOELASTIC BEHAVIOR; PHYSICAL-PROPERTIES; AMORPHOUS POLYMERS; BALLISTIC IMPACT; MODEL; DEFORMATION AB The stress relaxation behavior of a Twaron CT709 (R) fabric/natural rubber composite under a uniaxial constant strain is studied using three viscoelasticity models with different levels of complexity and a newly developed para-rheological model. The three viscoelasticity models employed are a one-term generalized Maxwell model (comprising one Maxwell element and an additional spring in parallel), a two-term generalized Maxwell model (including two Maxwell elements and an additional spring in parallel), and a four-parameter Burgers model. The values of the parameters involved in each model are extracted from the experimental data obtained in this study. The stress relaxation tests reveal that the stress starts to decay exponentially for a short duration and then continues to decrease linearly with time. It is found that the initial relaxation response of the composite is predicted fairly well by all of the four models, while the long-time stress relaxation behavior is more accurately predicted by the para-rheological model. The accuracy of each model in describing the stress relaxation behavior of the composite is quantitatively compared. [DOI:10.1115/1.4002636] C1 [Gao, X. -L.] Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. [David, N. V.] Univ Teknol MARA, Fac Mech Engn, Shah Alam 40450, Selangor, Malaysia. [Zheng, J. Q.] USA, Program Execut Off SOLDIER, Haymarket, VA 20169 USA. RP Gao, XL (reprint author), Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. EM xlgao@tamu.edu RI N.V., David/B-1987-2010 OI N.V., David/0000-0003-4128-5850 FU U.S. Army's Soldier Equipment Program FX The work reported here is partially funded by the U.S. Army's Soldier Equipment Program. This support is gratefully acknowledged. The authors also wish to thank Professor Valeria LaSaponara and two anonymous reviewers for their encouragement and helpful comments on an earlier version of the paper. NR 42 TC 2 Z9 2 U1 2 U2 6 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-4289 J9 J ENG MATER-T ASME JI J. Eng. Mater. Technol.-Trans. ASME PD JAN PY 2011 VL 133 IS 1 AR 011001 DI 10.1115/1.4002636 PG 9 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 695IK UT WOS:000285363600002 ER PT J AU Chen, CC Pestov, D Nelson, JD Anderson, JE Tepper, G AF Chen, Chien-Cheng Pestov, Dmitry Nelson, Jean D. Anderson, John E. Tepper, Gary TI Uranyl Soil Extraction and Fluorescence Enhancement by Nanoporous Silica Gel: pH effects SO JOURNAL OF FLUORESCENCE LA English DT Article DE Uranium; pH effect; Micro porous silica; Fluorescence; Soil ID SPECTROSCOPY TRLFS; URANIUM; SORPTION; IONS; SPECIATION; WATERS; ACID AB Nanoporous silica gel was employed to extract uranyl from contaminated soil and to enhance the fluorescence intensity and lifetime. The fluorescence lifetime and intensity of uranyl ions absorbed within nanoporous silica gel was measured from pH 1-13. The results show that the uranyl fluorescence intensity can be enhanced by approximately two orders of magnitude by the silica nanoporous matrix from pH 4-12 with the greatest enhancement occurring from pH 4-7. The enhanced fluorescence lifetime can be used in time-gated measurements to help minimize the influence of background environmental fluorophores. C1 [Chen, Chien-Cheng; Pestov, Dmitry; Tepper, Gary] Virginia Commonwealth Univ, Dept Mech Engn, Richmond, VA 23284 USA. [Nelson, Jean D.; Anderson, John E.] USA, Engineer Res & Dev Ctr, Topog Engn Ctr, Alexandria, VA 22315 USA. RP Tepper, G (reprint author), Virginia Commonwealth Univ, Dept Mech Engn, Med Coll Virginia Campus, Richmond, VA 23284 USA. EM gtepper@vcu.edu FU US Department of Energy [DE-FG52-06NA27491] FX This work was supported by the US Department of Energy under contract number DE-FG52-06NA27491. NR 22 TC 2 Z9 2 U1 0 U2 13 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1053-0509 J9 J FLUORESC JI J. Fluoresc. PD JAN PY 2011 VL 21 IS 1 BP 119 EP 124 DI 10.1007/s10895-010-0695-0 PG 6 WC Biochemical Research Methods; Chemistry, Analytical; Chemistry, Physical SC Biochemistry & Molecular Biology; Chemistry GA 716CV UT WOS:000286943500013 PM 20607370 ER PT J AU Nalca, A Nichols, DK AF Nalca, Aysegul Nichols, Donald K. TI Rabbitpox: a model of airborne transmission of smallpox SO JOURNAL OF GENERAL VIROLOGY LA English DT Review ID ANTIPOXVIRUS COMPOUND ST-246; MONKEYPOX VIRUS; RESPIRATORY-INFECTION; ORTHOPOXVIRUS INFECTION; ANIMAL-MODELS; POX II; DISEASE; EFFICACY; MICE; AFRICAN AB Smallpox is a human disease caused by infection with variola virus, a member of the genus Orthopoxvirus. Although smallpox has been eradicated, concern that it might be reintroduced through bioterrorism has therefore led to intensive efforts to develop new vaccines and antiviral drugs against this disease. Because these vaccines and therapeutics cannot be tested in human trials, it is necessary to test such medical countermeasures in different animal models. Although several orthopoxviruses cause disease in laboratory animals, only rabbitpox virus (RPXV) infection of rabbits shows patterns of natural airborne transmission similar to smallpox. Studies have shown that a smallpox-like disease can be produced in rabbits in a controlled fashion through exposure to a small-particle RPXV aerosol, and rabbitpox spreads from animal to animal by the airborne route in a laboratory setting. This model can therefore be utilized to test drugs and vaccines against variola virus and other aerosolized orthopoxviruses. C1 [Nalca, Aysegul] USA, Med Res Inst Infect Dis, Ctr Aerobiol Sci, Ft Detrick, MD 21702 USA. [Nichols, Donald K.] USA, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. RP Nalca, A (reprint author), USA, Med Res Inst Infect Dis, Ctr Aerobiol Sci, Ft Detrick, MD 21702 USA. EM aysegul.nalca@us.army.mil NR 39 TC 5 Z9 5 U1 0 U2 7 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 0022-1317 J9 J GEN VIROL JI J. Gen. Virol. PD JAN PY 2011 VL 92 BP 31 EP 35 DI 10.1099/vir.0.026237-0 PN 1 PG 5 WC Biotechnology & Applied Microbiology; Virology SC Biotechnology & Applied Microbiology; Virology GA 708MF UT WOS:000286365200003 PM 20965981 ER PT J AU Li, SH Cain, S Wosnik, M Miller, C Kocahan, H Wyckoff, R AF Li, Songheng Cain, Stuart Wosnik, Martin Miller, Chris Kocahan, Hasan Wyckoff, Russell TI Numerical Modeling of Probable Maximum Flood Flowing through a System of Spillways SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Article DE Spillways; Computational fluid dynamics technique; Floods; Numerical models; Simulation; Dam safety ID FREE-SURFACE FLOW; OGEE SPILLWAY; SIMULATION AB The results of a numerical model study of probable maximum flood (PMF) flow through a system of spillways consisting of an existing service spillway and a new auxiliary spillway are presented. A commercial computational fluid dynamics (CFD) code, Fluent, was used to solve the time-dependent Reynolds-averaged Navier-Stokes equations, a standard turbulence k-epsilon model with wall functions, and a water volume of fluid fraction equation. A two-dimensional approach velocity profile was used at the upstream inlet cross section. Water levels, flow splits between the existing and auxiliary spillways, and flow patterns were predicted and compared. A tentative design was chosen, constructed, and tested in a 1:54 scale physical model. Testing results were used to validate the CFD model. Results demonstrate that the CFD model is validated as accurate in the prediction of water levels in the reservoir, the integrated approach used is cost-effective and efficient in optimizing the designs of the auxiliary spillway, the tentative design cannot pass the PMF at the maximum pool level which suggests further modifications being necessary in the physical model. C1 [Li, Songheng; Cain, Stuart; Miller, Chris] Alden Res Lab Inc, Holden, MA 01520 USA. [Wosnik, Martin] Univ New Hampshire, Dept Mech Engn, Durham, NH 03824 USA. [Kocahan, Hasan] Hydroplus Inc, Arlington, VA 22203 USA. [Wyckoff, Russell] USA, Corps Engineers, Tulsa, OK 74128 USA. RP Li, SH (reprint author), Alden Res Lab Inc, 30 Shrewsbury St, Holden, MA 01520 USA. EM sli@aldenlab.com; sacain@aldenlab.com; martin.wosnik@unh.edu; cmiller@aldenlab.com; hasan.kocahan@hydroplus.com; Russell.Wyckoff@usace.army.mil RI Wosnik, Martin/L-5632-2013 OI Wosnik, Martin/0000-0001-9290-3327 NR 17 TC 6 Z9 6 U1 1 U2 5 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD JAN PY 2011 VL 137 IS 1 BP 66 EP 74 DI 10.1061/(ASCE)HY.1943-7900.0000279 PG 9 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA 696EM UT WOS:000285424700007 ER PT J AU Parish, RC Huang, JA Mansi, I AF Parish, Roy C. Huang, Jian Mansi, Ishak TI Screening for the Metabolic Syndrome in a Public Care Hospital Clinic Population: A Simple Measurement of Waist Circumference SO JOURNAL OF INVESTIGATIVE MEDICINE LA English DT Article DE metabolic syndrome; anthropomorphic measurement; receiver operator characteristic curves; screening tests ID INSULIN-RESISTANCE; PREVALENCE; DISEASE; PEOPLE; RISK AB Background: Metabolic syndrome is a collection of anthropomorphic and metabolic derangements that, taken together, constitute a strong predictor of stroke, cardiovascular disease, type 2 diabetes, and perhaps other disorders. Diagnosing the metabolic syndrome according to presently accepted definitions requires a mixture of anthropomorphic and laboratory measurements. In indigent patient populations or locations that lack adequate laboratory facilities, a noninvasive low-cost or cost-free alternative would be beneficial as a preliminary screening measure. Methods: To identify potential means for the diagnosis, we evaluated anthropomorphic measures individually and in combination for their predictive value against the standard classification. Receiver operator characteristic curves identified optimal cutoff values for the variables tested, and consideration of sensitivity and specificity were considered concerning the consequences of false negatives and positives. Results: Receiver operator characteristic curves showed that only waist circumference in men gave acceptable specificity and sensitivity. Combinations of measurements did not improve on a simple measurement of waist circumference. Conclusions: Waist circumference was a potentially useful single indicator in men but not in women. Other values and combinations were evaluated as well. Waist measurement alone may serve as sufficient screening in men in locations where laboratory facilities are lacking or funds are severely limited, as in developing countries. C1 [Parish, Roy C.] Univ Louisiana Monroe, Coll Pharm, Dept Clin & Adm Sci, Monroe, LA USA. [Parish, Roy C.] LSU Hlth Sci Ctr, Dept Internal Med, Shreveport, LA USA. [Huang, Jian] UCSF Fresno Med Educ Program, Dept Med, VA Cent Calif Healthcare Syst, Med Serv, Fresno, CA USA. [Mansi, Ishak] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Mansi, Ishak] UT Hlth Sci Ctr, San Antonio, TX USA. RP Parish, RC (reprint author), ULM Coll Pharm, Shreveport Campus,1725 Claiborne Ave, Shreveport, LA 71103 USA. EM rparis@lsuhsc.edu NR 17 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1081-5589 J9 J INVEST MED JI J. Invest. Med. PD JAN PY 2011 VL 59 IS 1 BP 22 EP 26 PG 5 WC Medicine, General & Internal; Medicine, Research & Experimental SC General & Internal Medicine; Research & Experimental Medicine GA 697TZ UT WOS:000285542500012 PM 21060286 ER PT J AU Bouldin, RM Kyriazidis, L Fidler, A Ravichandran, S Kumar, J Samuelson, LA Nagarajan, R AF Bouldin, Ryan M. Kyriazidis, Lucas Fidler, Allison Ravichandran, Sethumadhavan Kumar, Jayant Samuelson, Lynne A. Nagarajan, Ramaswamy TI Oxidoreductase Catalyzed Polymerization of 3-Methylpyrrole SO JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY LA English DT Article; Proceedings Paper CT 11th Technical Symposium of the University-of-Massachusetts-Lowell in Honor of Professor Sukant K Tripathy CY DEC, 2010 CL Lowell, MA SP Univ Massachusetts Lowell DE Conducting polymer; peroxidase; oxidoreductase; poly(3-methylpyrrole); polypyrrole derivative ID POLYMERS; CELLS AB A one-pot, environmentally friendly enzymatic method is described for the synthesis a polypyrrole derivative, poly(3-methylpyrrole) (poly(3-MP)) in an aqueous solvent system. The enzyme, soybean peroxidase (SBP), was shown to successfully polymerize the beta functionalized pyrrole monomer. The resulting polymer was semiconducting, thermally stable, and exhibited bipolaron absorptions when synthesized in the presence of poly(sodium 4-styrenesulfonate) (PSS). Polymers synthesized in the presence of 10-camphor sulfonic acid (CSA) were found to exhibit slightly higher conductivity values, but were less thermally stable compared to poly(3-MP) polymerized in the presence of PSS. This work should stimulate further interest in expanding the use of enzymes as catalysts for the polymerization of other pyrrole derivatives, as well as other classes of conjugated polymers. C1 [Nagarajan, Ramaswamy] Univ Massachusetts, Dept Plast Engn, Lowell, MA 01854 USA. [Bouldin, Ryan M.; Ravichandran, Sethumadhavan; Kumar, Jayant; Nagarajan, Ramaswamy] Univ Massachusetts, Ctr Adv Mat, Lowell, MA 01854 USA. [Bouldin, Ryan M.; Kyriazidis, Lucas] Univ Massachusetts, Dept Chem Engn, Lowell, MA 01854 USA. [Samuelson, Lynne A.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Nagarajan, R (reprint author), Univ Massachusetts, Dept Plast Engn, 1 Univ Ave, Lowell, MA 01854 USA. EM Ramaswamy_Nagarajan@uml.edu NR 11 TC 2 Z9 2 U1 2 U2 6 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1060-1325 J9 J MACROMOL SCI A JI J. Macromol. Sci. Part A-Pure Appl. Chem. PY 2011 VL 48 IS 12 BP 976 EP 982 DI 10.1080/10601325.2011.620413 PG 7 WC Polymer Science SC Polymer Science GA 884ZG UT WOS:000299746800003 ER PT J AU Li, L Yan, FD Samuelson, LA Kumar, J AF Li, Lian Yan, Fadong Samuelson, Lynne A. Kumar, Jayant TI Simple Two-Photon Inscription of Surface Relief Gratings with Azobenzene Functionalized Polymer SO JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY LA English DT Article; Proceedings Paper CT 11th Technical Symposium of the University-of-Massachusetts-Lowell in Honor of Professor Sukant K Tripathy CY DEC, 2010 CL Lowell, MA SP Univ Massachusetts Lowell DE Azobenzene; femtosecond laser; surface relief grating; phase mask; polarization ID LASER IRRADIATION; BRAGG GRATINGS; PHASE MASK; FILMS; FIBER AB Two-photon fabrication of surface relief gratings on azobenzene functionalized polymer films was carried out using femtosecond laser pulses at 800 nm. The two-photon inscriptions were achieved by simply employing a relief grating as a phase mask. The relief patterns were successfully recorded with the phase mask and the near-infrared laser pulses. The period of the grating is the same as that of the mask. Polarization dependent formation of the grating was observed. C1 [Yan, Fadong; Kumar, Jayant] Univ Massachusetts, Ctr Adv Mat, Lowell, MA 01854 USA. [Li, Lian; Samuelson, Lynne A.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Kumar, J (reprint author), Univ Massachusetts, Ctr Adv Mat, Lowell, MA 01854 USA. EM Jayant_Kumar@uml.edu NR 12 TC 0 Z9 0 U1 1 U2 6 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1060-1325 J9 J MACROMOL SCI A JI J. Macromol. Sci. Part A-Pure Appl. Chem. PY 2011 VL 48 IS 12 BP 1027 EP 1030 DI 10.1080/10601325.2011.620438 PG 4 WC Polymer Science SC Polymer Science GA 884ZG UT WOS:000299746800011 ER PT J AU Satapathi, S Li, L Anandakathir, R Samuelson, LA Kumar, J AF Satapathi, Soumitra Li, Lian Anandakathir, Robinson Samuelson, Lynne A. Kumar, Jayant TI Sensory Response and Two-Photon-Fluorescence Study of Regioregular Polythiophene Nanoparticles SO JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY LA English DT Article; Proceedings Paper CT 11th Technical Symposium of the University-of-Massachusetts-Lowell in Honor of Professor Sukant K Tripathy CY DEC, 2010 CL Lowell, MA SP Univ Massachusetts Lowell DE Polythiophene; sensor; nitroaromatic compounds; two-photon-induced fluorescence ID FLUORESCENCE; LANDMINES; EXPLOSIVES; TNT AB Nanoparticles of a regioregular and soluble polythiophene were fabricated by mini-emulsion technique. The fabricated nanoparticles were characterized by optical spectroscopy and dynamic light scattering. The fluorescence quenching of these fabricated nanoparticles with 2,4-dinitrotolune (DNT) in aqueous and organic solutions was investigated. Significant fluorescence quenching was observed. The Stern-Volmer constants were determined to be higher than that of the bulk polymer in solution, indicating that the nanoparticles provide better sensitivity in DNT sensing. Strong two-photon-induced fluorescence was measured from these nanoparticles. C1 [Satapathi, Soumitra; Anandakathir, Robinson; Kumar, Jayant] Univ Massachusetts, Ctr Adv Mat, Lowell, MA 01854 USA. [Satapathi, Soumitra; Kumar, Jayant] Univ Massachusetts, Dept Phys, Lowell, MA 01854 USA. [Li, Lian; Samuelson, Lynne A.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Kumar, J (reprint author), Univ Massachusetts, Ctr Adv Mat, Lowell, MA 01854 USA. EM Jayant_Kumar@uml.edu NR 15 TC 1 Z9 1 U1 1 U2 4 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1060-1325 J9 J MACROMOL SCI A JI J. Macromol. Sci. Part A-Pure Appl. Chem. PY 2011 VL 48 IS 12 BP 1049 EP 1054 DI 10.1080/10601325.2011.620452 PG 6 WC Polymer Science SC Polymer Science GA 884ZG UT WOS:000299746800015 ER PT J AU Kumar, V Gupta, B Khan, A Mosurkal, R Sharma, SK Parmar, VS Kumar, J Samuelson, LA Kumar, K Watterson, AC AF Kumar, Vijayendra Gupta, Bhavna Khan, Abdullah Mosurkal, Ravi Sharma, Sunil K. Parmar, Virinder S. Kumar, Jayant Samuelson, Lynne A. Kumar, Krishna Watterson, Arthur C. TI Crosslinking of Biocatalytically Synthesized Organosilicone Copolymers for Flame Retardant Applications SO JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY LA English DT Article; Proceedings Paper CT 11th Technical Symposium of the University-of-Massachusetts-Lowell in Honor of Professor Sukant K Tripathy CY DEC, 2010 CL Lowell, MA SP Univ Massachusetts Lowell DE Novozyme-435; Candida antarctica Lipase B; organosilicone co-polymers; flame retardant polymers; crosslinked polymers; nanoclay; thermogravimetric analysis (TGA); pyrolysis-combustion flow calorimetry (PCFC) ID NANOCOMPOSITES; POLYMERS AB Crosslinking of polymers using crosslinking agents has been widely utilized to further improve the mechanical and thermal properties of the polymers. We have explored various aliphatic and aromatic dicarboxylic acids such as malonic acid, glutaric acid, isophthalic acid, terephthalic acid and terephthaloyl chloride as crosslinking agents to crosslink polydimethylsiloxane copolymer [poly{poly(dimethylsiloxane-1000)-propylamine-5-aminoisophthaloyl}] to improve its flame retardant properties. We have also used nanoclays [Cloisite 20A, 2C(18) MMT (dimethylditallowammonium-/ dimethyldioctadecylammonium-modified montmorillonite)] along with the crosslinker during crosslinking process to further reduce the flammability of the crosslinked polymers. Among all the crosslinkers investigated, isophthalic acid with the nanoclay was found to have the best performance for flame retardant applications. The present work provides a basis to further improve the performance of silicone-based polymers for the flame retardant applications. C1 [Kumar, Vijayendra; Gupta, Bhavna; Sharma, Sunil K.; Parmar, Virinder S.; Kumar, Jayant; Watterson, Arthur C.] Univ Massachusetts, Inst Nanosci & Engn Technol, Dept Chem, Lowell, MA 01854 USA. [Kumar, Vijayendra; Kumar, Krishna] Howard Univ, Sch Pharm, Washington, DC 20059 USA. [Gupta, Bhavna; Sharma, Sunil K.; Parmar, Virinder S.; Kumar, Jayant; Watterson, Arthur C.] Univ Massachusetts, Ctr Adv Mat, Lowell, MA 01854 USA. [Khan, Abdullah; Sharma, Sunil K.; Parmar, Virinder S.] Univ Delhi, Dept Chem, Bioorgan Lab, Delhi 110007, India. [Mosurkal, Ravi; Samuelson, Lynne A.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Watterson, AC (reprint author), Univ Massachusetts, Inst Nanosci & Engn Technol, Dept Chem, Lowell, MA 01854 USA. EM arthur_watterson@uml.edu RI MOSURKAL, RAVI/P-6981-2015 NR 14 TC 2 Z9 2 U1 1 U2 12 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1060-1325 J9 J MACROMOL SCI A JI J. Macromol. Sci. Part A-Pure Appl. Chem. PY 2011 VL 48 IS 12 BP 1055 EP 1060 DI 10.1080/10601325.2011.620455 PG 6 WC Polymer Science SC Polymer Science GA 884ZG UT WOS:000299746800016 ER PT J AU Satapathi, S Ravichandran, S Mosurkal, R Nagarajan, S Li, L Nagarajan, R Samuelson, LA Kumar, J AF Satapathi, Soumitra Ravichandran, Sethumadhavan Mosurkal, Ravi Nagarajan, Subhalakshmi Li, Lian Nagarajan, Ramaswamy Samuelson, Lynne A. Kumar, Jayant TI Biocatalytic Synthesis of Two-Photon Active Resveratrol Oligomer SO JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY LA English DT Article; Proceedings Paper CT 11th Technical Symposium of the University-of-Massachusetts-Lowell in Honor of Professor Sukant K Tripathy CY DEC, 2010 CL Lowell, MA SP Univ Massachusetts Lowell DE Resveratrol; oligo-resveratrol; Horseradish Peroxidase; biocatalysis; Enzymatic; computational modeling; two-photon-fluorescence ID TRANS-RESVERATROL; WINE AB Resveratrol (3,5,4' trihydroxy trans-stilbene) is a plant based phenolic compound. Enzymatic oligomerization of trans-resveratrol using horseradish peroxidase followed by characterization of the oligomer is presented. The oligomerization reaction was monitored using UV-Visible absorption and fluorescence spectroscopies. The oligomer exhibits strong two-photon-induced fluorescence. Computational modeling using spin-density calculations was performed to investigate the most probable reaction sites and the nature of products formed in the oligomerization process. C1 [Satapathi, Soumitra; Kumar, Jayant] Univ Massachusetts, Ctr Adv Mat, Lowell, MA 01854 USA. [Satapathi, Soumitra; Kumar, Jayant] Univ Massachusetts, Dept Phys & Appl Phys, Lowell, MA 01854 USA. [Ravichandran, Sethumadhavan] Univ Massachusetts, Dept Chem, Lowell, MA 01854 USA. [Nagarajan, Ramaswamy] Univ Massachusetts, Dept Plast Engn, Lowell, MA 01854 USA. [Mosurkal, Ravi; Nagarajan, Subhalakshmi; Li, Lian; Samuelson, Lynne A.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Kumar, J (reprint author), Univ Massachusetts, Ctr Adv Mat, Lowell, MA 01854 USA. EM Jayant_Kumar@uml.edu RI MOSURKAL, RAVI/P-6981-2015 NR 10 TC 1 Z9 1 U1 0 U2 1 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1060-1325 J9 J MACROMOL SCI A JI J. Macromol. Sci. Part A-Pure Appl. Chem. PY 2011 VL 48 IS 12 BP 1061 EP 1066 DI 10.1080/10601325.2011.620461 PG 6 WC Polymer Science SC Polymer Science GA 884ZG UT WOS:000299746800017 ER PT J AU Long, JW Laskoski, M Peterson, GW Keller, TM Pettigrew, KA Schindler, BJ AF Long, Jeffrey W. Laskoski, Matthew Peterson, Gregory W. Keller, Teddy M. Pettigrew, Katherine A. Schindler, Bryan J. TI Metal-catalyzed graphitic nanostructures as sorbents for vapor-phase ammonia SO JOURNAL OF MATERIALS CHEMISTRY LA English DT Article ID CARBON NANOTUBE FORMATION; MODIFIED ACTIVATED CARBONS; SURFACE-CHEMISTRY; COBALT OXIDE; IN-SITU; NANOPARTICLE COMPOSITIONS; REACTIVE ADSORPTION; MICROPOROUS CARBON; OXYGEN; REMOVAL AB Activated carbons have long been used as substrates for the filtration of vapor-phase molecules, often with metal salts or oxides added to improve their sorption capacities for specific agents, but their real-world performance and applicability may be hindered by such factors as long-term stability and complex processing. En route to a new class of carbon-based sorbents, we have developed solid-state synthetic methods to produce bulk carbonaceous solids based on the pyrolysis of thermoset solids containing low concentrations (<1 wt%) of metal precursors (based on either Ni, Fe, or Co) that decompose in situ to catalyze the formation of a complex graphitic nanostructure. Selective combustion of residual amorphous carbon from the pyrolyzed solid generates a mesoporous network that facilitates diffusional transport of gas-phase molecules to the interior surfaces of the solid, and also converts the entrained metals to their respective metal oxide forms. We examine the ammonia-sorption properties of a series of these graphitic nanostructured compositions, and demonstrate that ammonia uptake is primarily determined by the type of residual metal oxide, with the Co-containing carbonaceous solid providing the best ammonia-sorption capacity (1.76 mol kg(-1)). Thermal reduction of the Co-containing material drastically decreases its ammonia-sorption capacity, showing that the oxide form (in this case Co(3)O(4)) of the entrained metal nanoparticles is most active for ammonia filtration. The effects of the carbon-oxygen functionalities on the nanostructured graphitic surfaces for ammonia sorption are also discussed. C1 [Long, Jeffrey W.; Pettigrew, Katherine A.] USN, Res Lab, Surface Chem Branch, Washington, DC 20375 USA. [Laskoski, Matthew; Keller, Teddy M.] USN, Res Lab, Mat Chem Branch, Washington, DC 20375 USA. [Peterson, Gregory W.] USA, Res Dev & Engn Command Edgewood Chem Biol Ctr, Res & Technol Directorate, CBR Filtrat Team, Aberdeen Proving Ground, MD 21010 USA. [Schindler, Bryan J.] SAIC Gunpowder Branch, Aberdeen Proving Ground, MD 21010 USA. RP Long, JW (reprint author), USN, Res Lab, Surface Chem Branch, Code 6170, Washington, DC 20375 USA. EM jeffrey.long@nrl.navy.mil RI Schindler, Bryan/I-1529-2013 OI Schindler, Bryan/0000-0003-3127-2722 FU Defense Threat Reduction Agency; Office of Naval Research FX Financial support for this project was provided by the Defense Threat Reduction Agency and the Office of Naval Research. The authors thank Dr Jean M. Wallace (Nova Research, Inc., Alexandria, VA) for assistance with the TPR experiments, and Dr Debra R. Rolison (Naval Research Laboratory) for helpful discussions in the preparation of this manuscript. NR 35 TC 13 Z9 13 U1 2 U2 29 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 0959-9428 J9 J MATER CHEM JI J. Mater. Chem. PY 2011 VL 21 IS 10 BP 3477 EP 3484 DI 10.1039/c0jm03167d PG 8 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 724OE UT WOS:000287585300033 ER PT J AU Xu, K von Cresce, A AF Xu, Kang von Cresce, Arthur TI Interfacing electrolytes with electrodes in Li ion batteries SO JOURNAL OF MATERIALS CHEMISTRY LA English DT Article ID TRANSFORM INFRARED-SPECTROSCOPY; RAY PHOTOELECTRON-SPECTROSCOPY; SPINEL CATHODE LIMN1.5NI0.5O4; ORIENTED PYROLYTIC-GRAPHITE; LITHIUM SECONDARY BATTERIES; SULFONE-BASED ELECTROLYTES; ATOMIC LAYER DEPOSITION; THIN-FILM ELECTRODES; LONG CYCLE LIFE; NATURAL GRAPHITE AB -A poetic definition of a binary liquid/solid interface by Luis de Camoes (1572). Since its birth in early 1990s, Li ion battery technology has been powering the rapid digitization of our daily life and finally made its debut in 2010 into the large format application for electrified vehicles such as the Nissan Leaf and GM Chevrolet Volt; however, much of the chemistry and processes underneath this amazing energy storage device still remain to be understood, among which is the interphase between electrolyte and electrodes. Interphases are formed in situ on electrode surfaces from sacrificial decomposition of electrolytes. Their ad hoc chemistry supports the reversible Li(+)-intercalation in both anode and cathode materials at extreme potentials, while preventing parasitic reductions/oxidations on the reactive surfaces of those electrodes; but their existence places restrictions on energy and power densities of the device by impeding Li(+)-transport and setting operating voltage limits, respectively. It has been the dream of battery engineers to maximize the former and minimize the latter. This review summarizes the most recent knowledge about the chemistry and formation mechanism of this elusive battery component on both anode and cathode surfaces. The attempts to tailor a desired interphasial chemistry via diversified means were also discussed. C1 [Xu, Kang; von Cresce, Arthur] USA, Res Lab, Sensor & Electron Devices Directorate, Electrochem Branch,Power & Energy Div, Adelphi, MD 20783 USA. RP Xu, K (reprint author), USA, Res Lab, Sensor & Electron Devices Directorate, Electrochem Branch,Power & Energy Div, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RI Cresce, Arthur/K-3958-2013 OI Cresce, Arthur/0000-0002-3894-6083 FU U. S. Department of Energy Advanced Battery Research (DOE-ABR) FX The work was partially funded by U. S. Department of Energy Advanced Battery Research (DOE-ABR) Program. The authors want to thank Dr Peter Faguy of DOE and Prof. Jeff Dahn of Dalhousie University for useful discussions. NR 124 TC 161 Z9 161 U1 15 U2 236 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 0959-9428 J9 J MATER CHEM JI J. Mater. Chem. PY 2011 VL 21 IS 27 BP 9849 EP 9864 DI 10.1039/c0jm04309e PG 16 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 784LV UT WOS:000292159700006 ER PT J AU Ren, XM Zhang, SS Tran, DT Read, J AF Ren, Xiaoming Zhang, Sheng S. Tran, Dat T. Read, Jeffrey TI Oxygen reduction reaction catalyst on lithium/air battery discharge performance SO JOURNAL OF MATERIALS CHEMISTRY LA English DT Article ID FLUORINATED ALKYL PHOSPHATES; LI-ION BATTERIES; LITHIUM/OXYGEN BATTERY; FLAME RETARDANTS; ELECTROLYTES; AIR; O-2; ENERGY AB Lithium/air batteries have the potential to substantially outperform the best battery system nowadays on the market. Oxygen reduction reaction (ORR) at the cathode in an aprotic organic lithium electrolyte is well-known to limit the discharge rate and capacity of the lithium/air batteries. In this study, the discharge characteristics of Li/air cells with cathodes made of different carbon materials were examined. The results showed that the ORR kinetics in the lithium/air batteries can be drastically improved by using an effective catalyst, achieving higher discharge voltage and rate. The discharge capacity of the lithium/air battery was found to be correlated to the cathode pore volume, to which the mesopore volume of the carbon material has a large contribution. An ORR mechanistic model involving a reaction product deactivating the catalytic sites on the carbon surface is proposed to explain the experimental results. C1 [Ren, Xiaoming; Zhang, Sheng S.; Tran, Dat T.; Read, Jeffrey] USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA. RP Ren, XM (reprint author), USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA. EM xiaoming.ren@us.army.mil RI ren, xiaoming/F-3953-2011; Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 23 TC 133 Z9 138 U1 11 U2 128 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 0959-9428 EI 1364-5501 J9 J MATER CHEM JI J. Mater. Chem. PY 2011 VL 21 IS 27 BP 10118 EP 10125 DI 10.1039/c0jm04170j PG 8 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 784LV UT WOS:000292159700035 ER PT J AU Watson, S AF Watson, Samuel TI Continuity in Civil-Military Relations and Expertise: The U.S. Army during the Decade before the Civil War SO JOURNAL OF MILITARY HISTORY LA English DT Article C1 US Mil Acad, West Point, NY 10996 USA. RP Watson, S (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 94 TC 1 Z9 1 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JAN PY 2011 VL 75 IS 1 BP 221 EP 250 PG 30 WC History SC History GA 708NK UT WOS:000286368300007 ER PT J AU Coss, EJ AF Coss, Edward J. TI An Atlas of the Peninsular War SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Coss, Edward J.] US Army Command, Ft Belvoir, VA USA. [Coss, Edward J.] Gen Staff Coll, Ft Belvoir, VA USA. RP Coss, EJ (reprint author), US Army Command, Ft Belvoir Campus, Ft Belvoir, VA USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JAN PY 2011 VL 75 IS 1 BP 268 EP 269 PG 2 WC History SC History GA 708NK UT WOS:000286368300018 ER PT J AU Kuehn, JT AF Kuehn, John T. TI To Train the Fleet for War: The U.S. Navy Fleet Problems, 1923-1940 SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Kuehn, John T.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Kuehn, JT (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JAN PY 2011 VL 75 IS 1 BP 306 EP 307 PG 2 WC History SC History GA 708NK UT WOS:000286368300045 ER PT J AU Boose, DW AF Boose, Donald W., Jr. TI Combat Ready? The Eighth US Army on the Eve of the Korean War SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Boose, Donald W., Jr.] USA, War Coll, Carlisle, PA USA. RP Boose, DW (reprint author), USA, War Coll, Carlisle, PA USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JAN PY 2011 VL 75 IS 1 BP 326 EP 327 PG 2 WC History SC History GA 708NK UT WOS:000286368300058 ER PT J AU Brandt, HE AF Brandt, Howard E. TI Warp-speed causal connectivity SO JOURNAL OF MODERN OPTICS LA English DT Article DE quantum field theory; microcausality; warp speed; maximal proper acceleration; spacetime tangent bundle ID VACUUM AB A possible consequence of a limiting proper acceleration relative to the vacuum is warp-speed causal connectivity near the Planck scale of spatial separation between two devices measuring the field, or at much larger separations when the relative speed of the two measuring devices is near the standard speed of light in vacuum. The modified quantum field is Lorentz invariant, and causal connectivity backward in time remains impossible. C1 USA, Res Lab, Adelphi, MD USA. RP Brandt, HE (reprint author), USA, Res Lab, Adelphi, MD USA. EM howard.e.brandt.civ@mail.mil NR 7 TC 0 Z9 0 U1 0 U2 1 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0950-0340 J9 J MOD OPTIC JI J. Mod. Opt. PY 2011 VL 58 IS 21 SI SI BP 1908 EP 1913 DI 10.1080/09500340.2011.591506 PG 6 WC Optics SC Optics GA 866RK UT WOS:000298399200003 ER PT J AU Fairchild, SZ Peterson, MW Hamza, A Zhan, CG Cerasoli, DM Chang, WLE AF Fairchild, Steven Z. Peterson, Matthew W. Hamza, Adel Zhan, Chang-Guo Cerasoli, Douglas M. Chang, Wenling E. TI Computational characterization of how the VX nerve agent binds human serum paraoxonase 1 SO JOURNAL OF MOLECULAR MODELING LA English DT Article DE Binding; Homology model; HuPON1; Steered molecular dynamics; Solvated interaction energy; VX ID SOLVATED INTERACTION ENERGY; ATOMIC CHARGES; ACTIVE-SITE; LACTONASE ACTIVITY; PROTEIN-STRUCTURE; DIISOPROPYL FLUOROPHOSPHATASE; ORBITAL ELECTRONEGATIVITY; EFFICIENT GENERATION; MOLECULAR-DYNAMICS; AUTOMATED DOCKING AB Human serum paraoxonase 1 (HuPON1) is an enzyme that can hydrolyze various chemical warfare nerve agents including VX. A previous study has suggested that increasing HuPON1's VX hydrolysis activity one to two orders of magnitude would make the enzyme an effective countermeasure for in vivo use against VX. This study helps facilitate further engineering of HuPON1 for enhanced VX-hydrolase activity by computationally characterizing HuPON1's tertiary structure and how HuPON1 binds VX. HuPON1's structure is first predicted through two homology modeling procedures. Docking is then performed using four separate methods, and the stability of each bound conformation is analyzed through molecular dynamics and solvated interaction energy calculations. The results show that VX's lone oxygen atom has a strong preference for forming a direct electrostatic interaction with HuPON1's active site calcium ion. Various HuPON1 residues are also detected that are in close proximity to VX and are therefore potential targets for future mutagenesis studies. These include E53, H115, N168, F222, N224, L240, D269, I291, F292, and V346. Additionally, D183 was found to have a predicted pKa near physiological pH. Given D183's location in HuPON1's active site, this residue could potentially act as a proton donor or accepter during hydrolysis. The results from the binding simulations also indicate that steered molecular dynamics can potentially be used to obtain accurate binding predictions even when starting with a closed conformation of a protein's binding or active site. C1 [Fairchild, Steven Z.] Mitre Corp, Mclean, VA 22102 USA. [Peterson, Matthew W.] Mitre Corp, Bedford, MA 01730 USA. [Hamza, Adel; Zhan, Chang-Guo] Univ Kentucky, Coll Pharm, Lexington, KY 40536 USA. [Cerasoli, Douglas M.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Chang, Wenling E.] Mitre Corp, San Diego, CA 92152 USA. RP Fairchild, SZ (reprint author), Mitre Corp, 7515 Colshire Dr, Mclean, VA 22102 USA. EM sfairchild@mitre.org FU Defense Threat Reduction Agency-Joint Science and Technology Office, Medical ST Division FX This research was supported by the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S&T Division. The opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army or the Department of Defense. NR 71 TC 15 Z9 15 U1 2 U2 14 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1610-2940 J9 J MOL MODEL JI J. Mol. Model. PD JAN PY 2011 VL 17 IS 1 BP 97 EP 109 DI 10.1007/s00894-010-0693-9 PG 13 WC Biochemistry & Molecular Biology; Biophysics; Chemistry, Multidisciplinary; Computer Science, Interdisciplinary Applications SC Biochemistry & Molecular Biology; Biophysics; Chemistry; Computer Science GA 710AL UT WOS:000286482700011 PM 20379755 ER PT J AU Lu, XCM Hartings, JA Si, YZ Balbir, A Cao, Y Tortella, FC AF Lu, Xi-Chun May Hartings, Jed A. Si, Yuanzheng Balbir, Alexander Cao, Ying Tortella, Frank C. TI Electrocortical Pathology in a Rat Model of Penetrating Ballistic-Like Brain Injury SO JOURNAL OF NEUROTRAUMA LA English DT Article DE electrophysiology; penetrating ballistic-like brain injury; rat ID LATERALIZED EPILEPTIFORM DISCHARGES; INTENSIVE-CARE-UNIT; NONCONVULSIVE STATUS EPILEPTICUS; CRITICALLY-ILL PATIENTS; PERIODIC EEG PATTERNS; TRAUMATIC BRAIN; HEAD-INJURY; INTRACEREBRAL HEMORRHAGE; ELECTROGRAPHIC SEIZURES; POSTTRAUMATIC EPILEPSY AB Traumatic brain injury (TBI) causes severe disruption of cerebral electrical activity and electroencephalography (EEG) is emerging as a standard tool to monitor TBI patients in the acute period of risk for secondary injuries. However, animal studies of EEG pathology in the context of TBI are surprisingly sparse, largely because of the lack of real-time continuous EEG (cEEG) monitoring in animal TBI models. Here, we performed long-term EEG monitoring to study nonconvulsive seizures (NCS), periodic epileptiform discharges (FED), and EEG power spectra following three injury severity levels in a rat model of penetrating ballistic-like brain injury (PBBI). EEG signals were recorded continuously from bilateral hemispheres of freely behaving rats for 72 h and for 2 h on days 7 and 14 after the injury. We report that the incidence of NCS and FED positively correlated with the injury severity, where 13%, 39%, and 59% of the animals exhibited NCS, and 0%, 30%, and 65% of the animals exhibited PED following 5%, 10% and 12.5% PBBI, respectively. Similar correlations existed for the number of NCS and FED events and their duration. NCS and FED occurred either independently or in tandem. Longer NCS durations were associated with larger lesion volumes. Significant EEG slowing evidenced by the EEG power shift toward the frequency band (0.5-4 Hz) occurred within 2 h after PBBI, which resolved over time but persisted longer after greater injury severity. In contrast, decreases in higher frequency power (i.e., 30-35 Hz) remained depressed throughout 14 days. This is the first long-term cEEG study of the acute injury phase in a rat model of severe TBI, demonstrating common occurrences of clinically observed electrocortical pathology, such as NCS, FED, and cortical slowing. These EEG pathologies may serve as critical care biomarkers of brain injury, and offer clinically relevant metrics for studying acute therapeutic interventions. C1 [Lu, Xi-Chun May; Hartings, Jed A.; Si, Yuanzheng; Balbir, Alexander; Cao, Ying; Tortella, Frank C.] Walter Reed Army Inst Res, Div Psychiat & Neurosci, Dept Appl Neurobiol, Silver Spring, MD 20910 USA. RP Lu, XCM (reprint author), Walter Reed Army Inst Res, Div Psychiat & Neurosci, Dept Appl Neurobiol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM may.lu@us.army.mil NR 86 TC 19 Z9 19 U1 0 U2 7 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JAN PY 2011 VL 28 IS 1 BP 71 EP 83 DI 10.1089/neu.2010.1471 PG 13 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 710DT UT WOS:000286491800007 PM 20964535 ER PT J AU O'Brien, C Blanchard, LA Cadarette, BS Endrusick, TL Xu, XJ Berglund, LG Sawka, MN Hoyt, RW AF O'Brien, Catherine Blanchard, Laurie A. Cadarette, Bruce S. Endrusick, Thomas L. Xu, Xiaojiang Berglund, Larry G. Sawka, Michael N. Hoyt, Reed W. TI Methods of Evaluating Protective Clothing Relative to Heat and Cold Stress: Thermal Manikin, Biomedical Modeling, and Human Testing SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article DE health hazard assessment; thermal strain; thermoregulation ID PHYSIOLOGICAL-RESPONSES; EXERCISE PERFORMANCE; INDUCED VASODILATION; CORE TEMPERATURE; THERMOREGULATION; HYPOHYDRATION; WORK; BODY; VASOCONSTRICTION; ACCLIMATIZATION AB Personal protective equipment (PPE) refers to clothing and equipment designed to protect individuals from chemical, biological, radiological, nuclear, and explosive hazards. The materials used to provide this protection may exacerbate thermal strain by limiting heat and water vapor transfer. Any new PPE must therefore be evaluated to ensure that it poses no greater thermal strain than the current standard for the same level of hazard protection. This review describes how such evaluations are typically conducted. Comprehensive evaluation of PPE begins with a biophysical assessment of materials using a guarded hot plate to determine the thermal characteristics (thermal resistance and water vapor permeability). These characteristics are then evaluated on a thermal manikin wearing the PPE, since thermal properties may change once the materials have been constructed into a garment. These data may be used in biomedical models to predict thermal strain under a variety of environmental and work conditions. When the biophysical data indicate that the evaporative resistance (ratio of permeability to insulation) is significantly better than the current standard, the PPE is evaluated through human testing in controlled laboratory conditions appropriate for the conditions under which the PPE would be used if fielded. Data from each phase of PPE evaluation are used in predictive models to determine user guidelines, such as maximal work time, work/rest cycles, and fluid intake requirements. By considering thermal stress early in the development process, health hazards related to temperature extremes can be mitigated while maintaining or improving the effectiveness of the PPE for protection from external hazards. C1 [O'Brien, Catherine; Cadarette, Bruce S.; Sawka, Michael N.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. [Blanchard, Laurie A.; Endrusick, Thomas L.; Xu, Xiaojiang; Berglund, Larry G.; Hoyt, Reed W.] USA, Environm Med Res Inst, Biophys & Biomed Modeling Div, Natick, MA 01760 USA. RP O'Brien, C (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. EM kate.obrien@us.army.mil NR 69 TC 10 Z9 10 U1 6 U2 46 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1545-9624 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2011 VL 8 IS 10 BP 588 EP 599 DI 10.1080/15459624.2011.613291 PG 12 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 829QD UT WOS:000295598200005 PM 21936698 ER PT J AU Knapik, JJ Spiess, A Swedler, D Grier, T Hauret, K Yoder, J Jones, BH AF Knapik, Joseph J. Spiess, Anita Swedler, David Grier, Tyson Hauret, Keith Yoder, James Jones, Bruce H. TI Retrospective examination of injuries and physical fitness during Federal Bureau of Investigation new agent training SO JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY LA English DT Article DE Overuse; trauma; law enforcement; physical training; gender; 1.5-mile run ID INFANTRY SOLDIERS; SPORTS INJURIES; ACTIVE ADULTS; RISK-FACTORS; YOUNG MEN; EPIDEMIOLOGY; ARMY; RECRUITS AB Background: A retrospective examination was conducted of injuries, physical fitness, and their association among Federal Bureau of Investigation (FBI) new agent trainees. Methods: Injuries and activities associated with injuries were obtained from a review of medical records in the medical clinic that served the new agents. A physical fitness test (PFT) was administered at Weeks 1, 7 and 14 of the 17-week new agent training course. The PFT consisted of push-ups, sit-ups, pull-ups, a 300-meter sprint, and a 1.5-mile run. Injury data were available from 2000 to 2008 and fitness data were available from 2004 to early 2009. Results: During the survey period, 37% of men and 44% of women experienced one or more injuries during the new agent training course (risk ratio (women/men) = 1.18, 95% confidence interval = 1.07-1.31). The most common injury diagnoses were musculoskeletal pain (not otherwise specified) (27%), strains (11%), sprains (10%), contusions (9%), and abrasions/lacerations (9%). Activities associated with injury included defensive tactics training (48%), physical fitness training (26%), physical fitness testing (6%), and firearms training (6%). Over a 6-year period, there was little difference in performance of push-ups, sit-ups, pull-ups, or the 300-meter sprint; 1.5-mile run performance was higher in recent years. Among both men and women, higher injury incidence was associated with lower performance on any of the physical fitness measures. Conclusion: This investigation documented injury diagnoses, activities associated with injury, and changes in physical fitness, and demonstrated that higher levels of physical fitness were associated with lower injury risk. C1 [Knapik, Joseph J.; Spiess, Anita; Grier, Tyson; Hauret, Keith; Jones, Bruce H.] USA, Inst Publ Hlth, Aberdeen Proving Ground, MD USA. [Swedler, David] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Yoder, James] Fed Bur Invest, Human Resources Div, Off Med Serv, Hlth Care Programs Unit, Washington, DC USA. RP Knapik, JJ (reprint author), USA, Inst Publ Hlth, Aberdeen Proving Ground, MD USA. EM joseph.knapik@us.army.mil FU FBI FX For the help they provided us on this project and for insights into the training of new agents, we would like to thank Dr. Thomas Gross, Ms Tanya Harvin, and Special Agents Timothy Burke, Susann Dreiling, Jay Moeller, Michael Vough, and Melina Casey. This project was funded by the FBI under an interagency agreement between the FBI and the US Army Public Health Command. NR 36 TC 4 Z9 4 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1745-6673 J9 J OCCUP MED TOXICOL JI J. Occup. Med. Toxicol. PY 2011 VL 6 AR 26 DI 10.1186/1745-6673-6-26 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA V27LX UT WOS:000208615800026 PM 21981817 ER PT J AU Long, KE AF Long, Kenneth E. TI Employees First, Customers Second: Turning Conventional Management Upside Down SO JOURNAL OF ORGANIZATIONAL CHANGE MANAGEMENT LA English DT Book Review C1 [Long, Kenneth E.] USA, Command & Gen Staff Coll, Leavenworth, KS USA. RP Long, KE (reprint author), USA, Command & Gen Staff Coll, Leavenworth, KS USA. NR 4 TC 0 Z9 0 U1 2 U2 2 PU EMERALD GROUP PUBLISHING LIMITED PI BINGLEY PA HOWARD HOUSE, WAGON LANE, BINGLEY BD16 1WA, W YORKSHIRE, ENGLAND SN 0953-4814 J9 J ORGAN CHANGE MANAG JI J. Organ. Chang. Manage. PY 2011 VL 24 IS 4 BP 559 EP 562 DI 10.1108/09534811111144665 PG 4 WC Management SC Business & Economics GA 817FO UT WOS:000294656900009 ER PT J AU Teyhen, D Koppenhaver, S AF Teyhen, Deydre Koppenhaver, Shane TI Rehabilitative ultrasound imaging SO JOURNAL OF PHYSIOTHERAPY LA English DT Editorial Material ID LOW-BACK-PAIN; LUMBAR MULTIFIDUS MUSCLE; TRANSVERSUS ABDOMINIS; THICKNESS C1 [Teyhen, Deydre; Koppenhaver, Shane] Baylor Univ, USA, Waco, TX 76798 USA. RP Teyhen, D (reprint author), Baylor Univ, USA, Waco, TX 76798 USA. NR 15 TC 2 Z9 2 U1 0 U2 6 PU AUSTRALIAN PHYSIOTHERAPY ASSOC PI ST KILDA PA LEVEL 3, 201 FITZROY ST, ST KILDA, 3182, AUSTRALIA SN 1836-9553 EI 1836-9561 J9 J PHYSIOTHER JI J. Physiother. PY 2011 VL 57 IS 3 BP 196 EP 196 PG 1 WC Orthopedics; Rehabilitation SC Orthopedics; Rehabilitation GA 816CD UT WOS:000294575400011 PM 21843838 ER PT J AU Steggall-Murphy, C Simacek, P Advani, SG Barthelemy, A Yarlagadda, S Walsh, S AF Steggall-Murphy, Claire Simacek, Pavel Advani, Suresh G. Barthelemy, Amandine Yarlagadda, Shridhar Walsh, Shawn TI A MODEL FOR PARTICLE DEPOSITION DURING IMPREGNATION OF FIBROUS POROUS MEDIA SO JOURNAL OF POROUS MEDIA LA English DT Article DE composite materials; particle impregnation; glass fiber composites; dual scale porous media; suspension flow ID CONCENTRATED SUSPENSIONS; FILTRATION PROCESSES; MEMBRANE FILTRATION; FIBER COMPOSITES; MIGRATION; PERFORMANCE; TRANSPORT; FILTERS; FLOW AB Filtration of particles in porous media is used for many applications, including desalination and water treatment, food manufacturing, paper making, and composites processing. In this paper, the deposition of thermoplastic particles is used to deliver matrix material within a composite textile. A constitutive model to describe the filtration behavior within the porous fabric with respect to time is proposed. The model requires characterization of a filtration coefficient that is a function of suspension concentration and shear rate. Experiments with different concentrations and shear rates are designed and conducted to measure the constants needed to characterize the filtration coefficient through regression analysis. The model is then compared with experimental data for a wide range of particle concentrations and fluid velocities. Although there is a difference between the model and the experimental results, the trends of the model are encouraging. C1 [Steggall-Murphy, Claire; Simacek, Pavel; Advani, Suresh G.; Barthelemy, Amandine] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. [Steggall-Murphy, Claire; Simacek, Pavel; Advani, Suresh G.; Barthelemy, Amandine; Yarlagadda, Shridhar] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. [Walsh, Shawn] USA, Res Lab, Aberdeen, MD 21005 USA. RP Advani, SG (reprint author), Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. EM advani@udel.edu FU Army Research Laboratory [W911NF-06-2-011] FX Research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-06-2-011. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation heron. NR 43 TC 4 Z9 5 U1 0 U2 15 PU BEGELL HOUSE INC PI REDDING PA 50 CROSS HIGHWAY, REDDING, CT 06896 USA SN 1091-028X J9 J POROUS MEDIA JI J. Porous Media PY 2011 VL 14 IS 5 BP 383 EP 394 PG 12 WC Thermodynamics; Engineering, Mechanical; Mechanics SC Thermodynamics; Engineering; Mechanics GA 773ST UT WOS:000291331400002 ER PT J AU Petrov, D Shkuratov, Y Videen, G AF Petrov, Dmitry Shkuratov, Yuriy Videen, Gorden TI Electromagnetic wave scattering from cuboid-like particles using Sh-matrices SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article; Proceedings Paper CT 1st International Symposium on Atmospheric Light Scattering and Remote Sensing CY JUL 13-17, 2009 CL Xian, PEOPLES R CHINA SP Xian Univ Technol, Sch Machinery & Precis Instrument Engn DE Light scattering; T-matrix; Shape matrix; Cuboid ID LIGHT-SCATTERING; CAPSULE AB The Sh-matrix elements derived from the T-matrix technique allow one to separate the shape-dependent parameters from size- and refractive-index-dependent parameters. The separation also allows the corresponding surface integrals to be solved analytically for different particle shapes. In this manuscript we give analytical expressions for the Sh-matrix elements that contain the shape information for cuboid-like particles. We find very good agreement between the results obtained using the Sh-matrix method and those using the discrete-dipole approximation (DDA). The solution gives significant acceleration of calculations dependently on the size parameter of particles. Published by Elsevier Ltd. C1 [Videen, Gorden] USA, Res Lab, AMSRD ARL CI EM, Adelphi, MD 20783 USA. [Petrov, Dmitry; Shkuratov, Yuriy] Kharkov Natl Univ, Astron Inst Kharkov, UA-61022 Kharkov, Ukraine. RP Videen, G (reprint author), USA, Res Lab, AMSRD ARL CI EM, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM petrov@astron.kharkov.ua; gvideen@arl.army.mil NR 14 TC 3 Z9 3 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD JAN PY 2011 VL 112 IS 2 SI SI BP 155 EP 162 DI 10.1016/j.jqsrt.2010.01.024 PG 8 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 702LQ UT WOS:000285896600002 ER PT J AU Sun, WB Hu, YX Lin, B Liu, ZY Videen, G AF Sun, Wenbo Hu, Yongxiang Lin, Bing Liu, Zhaoyan Videen, Gorden TI The impact of ice cloud particle microphysics on the uncertainty of ice water content retrievals SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article; Proceedings Paper CT 1st International Symposium on Atmospheric Light Scattering and Remote Sensing CY JUL 13-17, 2009 CL Xian, PEOPLES R CHINA SP Xian Univ Technol, Sch Machinery & Precis Instrument Engn DE Ice clouds; Cloud radar; Ice water content ID TIME-DOMAIN SOLUTION; LIGHT-SCATTERING; CIRRUS CLOUDS; RADAR; LIDAR; MISSION; PRECIPITATION; OCEANS; PATH AB Ice water content (IWC) is a standard product of cloud radar measurements. In this work, cloud radar cross-sections of various ice clouds are modeled to examine the relationship between the radar signal and the IWC. We report that using backscatter signal at cloud radar wavelength to retrieve IWC results in large uncertainties. Particle size distribution is the primary cause for the uncertainty in the retrieved IWC at radar wavelengths, though particle shape and orientation also play significant roles. Particularly in this study, we demonstrate that using both transmitted waves through the clouds (extinction) and backscattered waves from the clouds to retrieve the mean particle size and then using the mean particle size for IWC retrieval reduces the uncertainty. IWC retrieval can be improved with size distribution derived from dual wavelength cloud radar. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Sun, Wenbo; Hu, Yongxiang; Lin, Bing] NASA, Langley Res Ctr, Hampton, VA 23681 USA. [Sun, Wenbo] Sci Syst & Applicat Inc, Hampton, VA 23666 USA. [Liu, Zhaoyan] Natl Inst Aerosp, Hampton, VA 23666 USA. [Videen, Gorden] USA, Res Lab, Adelphi, MD 20783 USA. RP Sun, WB (reprint author), NASA, Langley Res Ctr, Mail Stop 420, Hampton, VA 23681 USA. EM Wenbo.Sun-1@nasa.gov RI Liu, Zhaoyan/B-1783-2010; Hu, Yongxiang/K-4426-2012 OI Liu, Zhaoyan/0000-0003-4996-5738; NR 20 TC 9 Z9 10 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD JAN PY 2011 VL 112 IS 2 SI SI BP 189 EP 196 DI 10.1016/j.jqsrt.2010.04.003 PG 8 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 702LQ UT WOS:000285896600007 ER PT J AU Yancosek, KE Mullineaux, DR AF Yancosek, Kathleen E. Mullineaux, David R. TI Stability of handwriting performance following injury-induced hand-dominance transfer in adults: A pilot study SO JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT LA English DT Article DE activities of daily living; amputation; handwriting; hand dominance; injury-induced hand-dominance transfer; Jebsen-Taylor Test of Hand Function; kinematics; performance; reliability; stability ID HANDEDNESS; PAIN AB The aim of this study was to quantify stability of nondominant handwriting kinematics and legibility in participants with functional loss of the previously dominant hand. Twelve adult volunteers provided two handwriting samples 6 weeks apart. Handwriting tasks (Compose a Sentence, Copy Alphabet, Copy Date, Copy Sentence, and Draw Circles) were performed in cursive writing on standard white, lined paper taped to a digitizer to record kinematic and kinetic variables of velocity, displacement, force, and on-paper time. Results showed minimal performance variability within subjects and marked variability between subjects, as well as variability between tasks for all participants. Stylistic stability of the handwriting samples was assessed by two independent evaluators. These evaluators matched all handwriting samples at test to retest times with 89%-100% accuracy, suggesting value in the "whole" handwriting sample and emphasizing the idiosyncratic nature of handwriting. Results suggest that handwriting skill stability in the previously nondominant hand varies across subjects and task demands. C1 [Yancosek, Kathleen E.] Univ Kentucky, Dept Rehabil Sci, Coll Hlth Sci, Lexington, KY USA. [Mullineaux, David R.] Univ Kentucky, Dept Kinesiol & Hlth Promot, Coll Educ, Lexington, KY USA. [Mullineaux, David R.] Lincoln Univ, Brayford Pool, Lincs, England. RP Yancosek, KE (reprint author), USA, Environm Med Res Inst, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM kathleen.yancosek@us.army.mil OI Mullineaux, David/0000-0002-5688-404X FU University of Kentucky's Center for Clinical and Translational Science FX This material was based on work supported by a $5,000 Seed Grant from the University of Kentucky's Center for Clinical and Translational Science. NR 27 TC 11 Z9 11 U1 0 U2 7 PU JOURNAL REHAB RES & DEV PI BALTIMORE PA DEPT OF VETERANS AFFAIRS REHABIL RES & DEVELOP CTR 103 SOUTH GAY STREET, BALTIMORE, MD 21202-4051 USA SN 0748-7711 J9 J REHABIL RES DEV JI J. Rehabil. Res. Dev. PY 2011 VL 48 IS 1 BP 59 EP 68 DI 10.1682/JRRD.2010.04.0074 PG 10 WC Rehabilitation SC Rehabilitation GA 719SG UT WOS:000287228700006 PM 21328163 ER PT J AU Resnik, L Gray, M Borgia, M AF Resnik, Linda Gray, Melissa Borgia, Matthew TI Measurement of community reintegration in sample of severely wounded servicemembers SO JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT LA English DT Article DE community reintegration; disability; measurement; military healthcare; outcomes assessment; participation; psychometric testing; reliability; traumatic brain injury; veterans ID TRAUMATIC-BRAIN-INJURY; POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; VIETNAM VETERANS; DISABILITY; COMBAT; AFGHANISTAN; INTEGRATION; DEPLOYMENT; HANDICAP AB The Community Reintegration of Servicemembers (CRIS) is a new measure of community reintegration. The purpose of this study was to test the CRIS with seriously injured combat veterans. Subjects were 68 patients at the Center for the Intrepid. Each patient completed three CRIS subscales, the 3-6Item Short Form Health Survey for Veterans (SF-36V), the Quality of Life Scale (QOLS), and two Craig Handicap Assessment and Reporting Technique subscales at visit 1 and the 3-month follow-up. Of the patients, 11 also completed the measures within 2 weeks of visit 1. We abstracted diagnoses and activities of daily living from the medical record. We evaluated test-retest reliability using intraclass correlation coefficients (ICCs). We evaluated concurrent validity with Pearson product moment correlations. We used multivariate analyses of variance to compare scores for subjects with and without posttraumatic stress disorder (PTSD), traumatic brain injury (TBI), and depression. Responsiveness analyses evaluated floor and ceiling effects, percent achieving minimal detectable change (MDC), effect size (ES), and the standardized response mean (SRM). CRIS subscale ICCs were 0.90 to 0.91. All subscales were moderately or strongly correlated with QOLS and SF-36V subscales. CRIS subscale scores were lower in PTSD and TBI groups (p < 0.05). CRIS Extent of Participation and Satisfaction with Participation subscales were lower for subjects with depression (p < 0.05). Of the sample, 17.4% to 23.2% had change greater than MDC. The ES ranged from 0.227 to 0.273 (SRM = 0.277-0.370), showing a small effect between visit 1 and the 3-month follow-up. Results suggest that the CRIS is a psychometrically sound choice for community reintegration measurement in severely wounded servicemembers. C1 [Resnik, Linda] Providence Dept Vet Affairs Med Ctr, Providence, RI USA. [Resnik, Linda; Borgia, Matthew] Brown Univ, Dept Community Hlth, Providence, RI 02912 USA. [Gray, Melissa] Brooke Army Med Ctr, San Antonio, TX USA. RP Resnik, L (reprint author), Providence VA Med Ctr, 830 Chalkstone Ave, Providence, RI 02908 USA. EM Linda_Resnik@brown.edu FU VA, Veterans Health Administration, Office of Research and Development, Health Services Research and Development [SDR-07-327] FX This material was based on work supported by the VA, Veterans Health Administration, Office of Research and Development, Health Services Research and Development (grant SDR-07-327). NR 35 TC 12 Z9 13 U1 0 U2 9 PU JOURNAL REHAB RES & DEV PI BALTIMORE PA DEPT OF VETERANS AFFAIRS REHABIL RES & DEVELOP CTR 103 SOUTH GAY STREET, BALTIMORE, MD 21202-4051 USA SN 0748-7711 J9 J REHABIL RES DEV JI J. Rehabil. Res. Dev. PY 2011 VL 48 IS 2 BP 89 EP 101 DI 10.1682/JRRD.2010.04.0070 PG 13 WC Rehabilitation SC Rehabilitation GA 733BQ UT WOS:000288235800002 PM 21480084 ER PT J AU Mwamukonda, K Chi, T Shindel, A Lue, T AF Mwamukonda, K. Chi, T. Shindel, A. Lue, T. TI ANDROGEN BLOCKADE FOR THE TREATMENT OF HIGH FLOW PRIAPISM SO JOURNAL OF SEXUAL MEDICINE LA English DT Meeting Abstract C1 [Mwamukonda, K.] Brooke Army Med Ctr, Ft San Houston, TX USA. [Chi, T.; Lue, T.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Shindel, A.] Univ Calif Davis, Sacramento, CA 95817 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1743-6095 J9 J SEX MED JI J. Sex. Med. PD JAN PY 2011 VL 8 SU 1 BP 20 EP 20 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA 702WL UT WOS:000285926500055 ER PT J AU Shirreffs, SM Sawka, MN AF Shirreffs, Susan M. Sawka, Michael N. TI Fluid and electrolyte needs for training, competition, and recovery SO JOURNAL OF SPORTS SCIENCES LA English DT Article DE Hydration; water balance; fluid replacement ID EXERCISE-INDUCED DEHYDRATION; HEAT-STRESS; THERMOREGULATORY RESPONSES; POSTEXERCISE REHYDRATION; CYCLING PERFORMANCE; AEROBIC PERFORMANCE; PROLONGED EXERCISE; COGNITIVE FUNCTION; DRINK TEMPERATURE; CORE TEMPERATURE AB Fluids and electrolytes (sodium) are consumed by athletes, or recommended to athletes, for a number of reasons, before, during, and after exercise. These reasons are generally to sustain total body water, as deficits (hypohydration) will increase cardiovascular and thermal strain and degrade aerobic performance. Vigorous exercise and warm/hot weather induce sweat production, which contains both water and electrolytes. Daily water (4-10 L) and sodium (3500-7000 mg) losses in active athletes during hot weather exposure can induce water and electrolyte deficits. Both water and sodium need to be replaced to re-establish "normal" total body water (euhydration). This replacement can be by normal eating and drinking practices if there is no urgency for recovery. But if rapid recovery (<24 h) is desired or severe hypohydration (>5% body mass) is encountered, aggressive drinking of fluids and consuming electrolytes should be encouraged to facilitate recovery for subsequent competition. C1 [Shirreffs, Susan M.] Univ Loughborough, Sch Sport Exercise & Hlth Sci, Loughborough LE11 3TU, Leics, England. [Sawka, Michael N.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Shirreffs, SM (reprint author), Univ Loughborough, Sch Sport Exercise & Hlth Sci, Loughborough LE11 3TU, Leics, England. EM s.shirreffs@lboro.ac.uk NR 65 TC 27 Z9 27 U1 4 U2 51 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0264-0414 J9 J SPORT SCI JI J. Sports Sci. PY 2011 VL 29 SU 1 SI SI BP S39 EP S46 DI 10.1080/02640414.2011.614269 PG 8 WC Sport Sciences SC Sport Sciences GA 886ZQ UT WOS:000299894900006 PM 22150427 ER PT J AU Daddis, GA AF Daddis, Gregory A. TI The Limits of U.S. Military Capability: Lessons from Vietnam and Iraq SO JOURNAL OF STRATEGIC STUDIES LA English DT Book Review C1 [Daddis, Gregory A.] US Mil Acad, West Point, NY 10996 USA. RP Daddis, GA (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0140-2390 J9 J STRATEGIC STUD JI J. Strateg. Stud. PY 2011 VL 34 IS 2 BP 287 EP 289 PG 3 WC International Relations; Political Science SC International Relations; Government & Law GA 753SO UT WOS:000289800200009 ER PT J AU Echevarria, AJ AF Echevarria, Antulio J., II TI 'Strategy' as Prologue? SO JOURNAL OF STRATEGIC STUDIES LA English DT Editorial Material C1 USA, War Coll, Carlisle, PA 17013 USA. RP Echevarria, AJ (reprint author), USA, War Coll, Carlisle, PA 17013 USA. NR 3 TC 1 Z9 1 U1 0 U2 0 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0140-2390 J9 J STRATEGIC STUD JI J. Strateg. Stud. PY 2011 VL 34 IS 4 BP 501 EP 507 DI 10.1080/01402390.2011.594680 PG 7 WC International Relations; Political Science SC International Relations; Government & Law GA 826MN UT WOS:000295358400004 ER PT J AU Burgess, PL Brockmeyer, JR Johnson, EK AF Burgess, Pamela L. Brockmeyer, Joel R. Johnson, Eric K. TI Amyand Hernia Repaired with Bio-A: A Case Report and Review SO JOURNAL OF SURGICAL EDUCATION LA English DT Review DE Amyand; hernia; appendix; biological mesh; Bio-A ID APPENDICITIS AB A 53-year-old man with an Amyand hernia with indirect and direct components was repaired with a Bio-A (Gore, Newark, Delaware) plug and a patch made of Bio-A tissue reinforcement material. The repair of an Amyand hernia addresses the pathology of the appendix as well as the hernia. We report a case in which a plug and patch repair was undertaken using Bio-A implants in a clean-contaminated field with no signs of infection or recurrence in the follow-up period, and we review the literature regarding the diagnosis and repair of an Amyand hernia. U Surg 68:62-66. Published by Elsevier Inc. on behalf of the Association of Program Directors in Surgery.) C1 [Burgess, Pamela L.; Brockmeyer, Joel R.; Johnson, Eric K.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. RP Burgess, PL (reprint author), Dwight D Eisenhower Army Med Ctr, 300 E Hosp Rd, Ft Gordon, GA 30905 USA. EM pamela.burgess@us.army.mil NR 22 TC 6 Z9 7 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1931-7204 J9 J SURG EDUC JI J. Surg. Educ. PD JAN-FEB PY 2011 VL 68 IS 1 BP 62 EP 66 DI 10.1016/j.jsurg.2010.09.006 PG 5 WC Education, Scientific Disciplines; Surgery SC Education & Educational Research; Surgery GA 722IC UT WOS:000287424900013 PM 21292218 ER PT J AU Pinsker, JE Nguyen, C Young, S Fredericks, GJ Chan, D AF Pinsker, Jordan E. Nguyen, Charles Young, Susan Fredericks, Gregory J. Chan, Debora TI A pilot project for improving paediatric diabetes outcomes using a website: the Pediatric Diabetes Education Portal SO JOURNAL OF TELEMEDICINE AND TELECARE LA English DT Article ID METABOLIC-CONTROL; CONTROLLED-TRIAL; MANAGEMENT; ADOLESCENTS; MELLITUS; GLUCOSE AB We created a website for patients and families that allowed them to review clinic test results, review educational materials related to these results and post questions to their diabetes educator. Fingerstick haemoglobin A(1c) (HbA(1c)) testing and periodic use of a continuous glucose monitoring system (CGMS) were offered to all patients. The HbA(1c) and CGMS results were posted to the website after each clinic visit. A total of 52 patients with type 1 diabetes were enrolled in the study. There were 16 patients with HbA(1c) values within ADA guidelines and 16 with HbA(1c) values above guidelines; 20 patients were excluded for various reasons. Users of the website were defined as families who logged in four or more times over the six-month study period. For patients whose HbA(1c) started above ADA guidelines, the mean HbA(1c) for website users decreased from 10.5% (SD 2.2) at baseline to 9.1% (SD 1.2) after six months. In the non-users, the mean HbA(1c) increased from 9.5% (SD 1.5) at baseline to 10.4% (SD 2.5). However, these changes were not significant. A between groups comparison (users versus non-users) showed a significant improvement in HbA(1c) for website users (P = 0.03). This change in HbA(1c) was clinically relevant. Further studies with more patients are needed to see if these improvements can be sustained over a longer period. C1 [Pinsker, Jordan E.] Tripler Army Med Ctr, Dept Pediat Endocrinol, Honolulu, HI 96859 USA. [Young, Susan] Kaiser Permanente Hawaii, Waipahu, HI USA. RP Pinsker, JE (reprint author), Tripler Army Med Ctr, Dept Pediat Endocrinol, Mail Code MCHK PE,1 Jarrett White Rd, Honolulu, HI 96859 USA. EM jordan.pinsker@us.army.mil OI Pinsker, Jordan/0000-0003-4080-9034 FU AMEDD Advanced Medical Technology Initiative through the Telemedicine and Advanced Technology Research Center FX We thank Dr C Becket Mahnke for his assistance in creating the PDEP website. We also thank Mr Ri Wen Li for assistance in linking laboratory results to the PDEP and Ms Eludrizza Tabisola-Nuesca, Dr Anita Pedersen and Dr David Crudo for providing care for patients on the website. The work was funded by the AMEDD Advanced Medical Technology Initiative through the Telemedicine and Advanced Technology Research Center. The views expressed here are those of the authors and do not reflect the official policy or position of the Department of the Army, Department of Defense, or the US Government. NR 16 TC 11 Z9 11 U1 1 U2 3 PU ROYAL SOC MEDICINE PRESS LTD PI LONDON PA 1 WIMPOLE STREET, LONDON W1G 0AE, ENGLAND SN 1357-633X J9 J TELEMED TELECARE JI J. Telemed. Telecare PY 2011 VL 17 IS 5 BP 226 EP 230 DI 10.1258/jtt.2010.100812 PG 5 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 812SG UT WOS:000294312600003 PM 21565846 ER PT J AU Detweiler, MB Arif, S Candelario, J Altman, J Murphy, PF Halling, MH Detweiler, JG Vasudeve, S AF Detweiler, Mark B. Arif, Saira Candelario, Joseph Altman, Joanne Murphy, Pamela F. Halling, Mary H. Detweiler, Jonna G. Vasudeve, Sachinder TI A telepsychiatry transition clinic: the first 12 months experience SO JOURNAL OF TELEMEDICINE AND TELECARE LA English DT Article ID SATISFACTION; TELEMEDICINE AB To improve the management of soldiers with combat-related mental health problems, an interdisciplinary telepsychiatry service was established between a clinic at the Fort Bragg army base and the Veterans Affairs (VA) Medical Center in Salem. In the first 12 months of operation, 120 soldiers (105 males) were seen in a total of 394 telepsychiatry sessions. The time spent on telepsychiatry by the six VA psychiatrists increased from 1 3 hours in the first month to 41 hours in the twelfth month. The number of telepsychiatry sessions increased from nine in the first month to 56 in the twelfth month. The mean global assessment of function score (GAF) in the soldiers increased significantly (P < 0.001) from 58.0 at intake to 62.3 at the last visit. Soldiers received VA telepsychiatry on average 22 days after the initial consultation with a primary care provider, a reduction of at least eight days compared to the previous delay. The majority of soldiers (89%) who were treated by VA psychiatrists enrolled in the VA within about six months of discharge. Similar VA-US Military collaborations may prove beneficial for other military bases that have returning combat soldiers. C1 [Detweiler, Mark B.; Halling, Mary H.; Detweiler, Jonna G.] Salem VAMC, Geriatr Res Grp, Salem, VA USA. [Detweiler, Mark B.; Vasudeve, Sachinder] Virginia Tech, Caril Sch Med, Dept Psychiat & Behav Med, Roanoke, VA USA. [Arif, Saira] Univ Virginia, Roanoke Salem Psychiat Med Residency Program, Carilion Clin, Roanoke, VA USA. [Candelario, Joseph] Salem VAMC, Emergency Dept, Salem, VA USA. [Altman, Joanne] USA, Warrior Transit Clin, Ft Bragg, NC USA. [Murphy, Pamela F.] Virginia Tech, Blacksburg, VA USA. RP Detweiler, MB (reprint author), Vet Affairs Med Ctr, Mental Hlth Serv Line 116A7,1970 Roanoke Blvd, Salem, VA 24153 USA. EM mark.detweiler1@va.gov NR 16 TC 5 Z9 5 U1 2 U2 6 PU ROYAL SOC MEDICINE PRESS LTD PI LONDON PA 1 WIMPOLE STREET, LONDON W1G 0AE, ENGLAND SN 1357-633X J9 J TELEMED TELECARE JI J. Telemed. Telecare PY 2011 VL 17 IS 6 BP 293 EP 297 DI 10.1258/jtt.2011.100804 PG 5 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 824IZ UT WOS:000295196900004 PM 21844181 ER PT J AU Born, CT Cullison, TR Dean, JA Hayda, RA McSwain, N Riddles, LM Shimkus, AJ AF Born, Christopher T. Cullison, Thomas R. Dean, Jeffrey A. Hayda, Roman A. McSwain, Norman Riddles, Lawrence M. Shimkus, Albert J. TI Partnered Disaster Preparedness: Lessons Learned From International Events SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS LA English DT Article AB Military, governmental, and civilian agencies routinely respond to disasters around the world, including large-scale mass casualty events such as the earthquake in Pakistan in 2005, Hurricane Katrina in the United States in 2005, and the earthquake in Haiti in 2010. Potential exists for improved coordination of medical response between civilian and military sectors and for the creation of a planned and practiced interface. Disaster preparedness could be enhanced with more robust disaster education for civilian responders; creation of a database of precredentialed, precertified medical specialists; implementation of a communication bridge; and the establishment of agreements between military and civilian medical/surgical groups in advance of major catastrophic events. C1 [Born, Christopher T.; Hayda, Roman A.] Brown Univ, Warren Alpert Med Sch, Providence, RI 02912 USA. [Born, Christopher T.; Hayda, Roman A.] Rhode Isl Hosp, Orthopaed Trauma Serv, Providence, RI USA. [Cullison, Thomas R.] Bur Med & Surg, Washington, DC USA. [Dean, Jeffrey A.] Munson Army Hlth Ctr, Ft Leavenworth, KS USA. [McSwain, Norman] Tulane Univ, Sch Med, New Orleans, LA 70112 USA. [McSwain, Norman] Tulane Univ, Spirit Char Trauma Ctr, New Orleans, LA 70112 USA. [Riddles, Lawrence M.] US Transportat Command, Scott AFB, IL USA. [Shimkus, Albert J.] Naval War Coll, Newport, RI USA. RP Born, CT (reprint author), Brown Univ, Warren Alpert Med Sch, Providence, RI 02912 USA. FU Stryker FX Dr. Born or an immediate family member serves as a board member, owner, officer, or committee member of the American College of Surgeons, the Orthopaedic Trauma Association, the American Academy of Surgeons, and the Foundation for Orthopaedic Trauma; serves as a paid consultant to Stryker and IlluminOss Medical; serves as an unpaid consultant to BioIntraface; has received research or institutional support from Stryker; and has stock or stock options held in BioIntraface and IlluminOss Medical. Dr. Hayda or an immediate family member is a member of a speakers' bureau or has made paid presentations on behalf of AO North America and serves as an unpaid consultant to BioIntraface. None of the following authors or any immediate family member has received anything of value from or owns stock in a commercial company or institution related directly or indirectly to the subject of this article: Rear Admiral Cullison, Dr. Dean, Dr. McSwain, Dr. Riddles, and Captain Shimkus. NR 9 TC 7 Z9 7 U1 1 U2 8 PU AMER ACAD ORTHOPAEDIC SURGEONS PI ROSEMENT PA 6300 N RIVER ROAD, ROSEMENT, IL 60018-4262 USA SN 1067-151X J9 J AM ACAD ORTHOP SUR JI J. Am. Acad. Orthop. Surg. PY 2011 VL 19 SU 1 BP S44 EP S48 PG 5 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 722IE UT WOS:000287425100010 PM 21304048 ER PT J AU Cross, JD Ficke, JR Hsu, JR Masini, BD Wenke, JC AF Cross, Jessica D. Ficke, James R. Hsu, Joseph R. Masini, Brendan D. Wenke, Joseph C. TI Battlefield Orthopaedic Injuries Cause the Majority of Long-term Disabilities SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS LA English DT Article ID OPERATION ENDURING FREEDOM; IRAQI FREEDOM; OUTCOMES; WOUNDS; TRAUMA AB Extremity injuries make up 54% of combat wounds sustained in Operation Iraqi Freedom and Operation Enduring Freedom. In a cohort of war-wounded service members, we identified the conditions secondary to battle injury that result in disqualification from continued service. The Army Physical Evaluation Board records of 464 wounded service members who were injured between October 2001 and January 2005 were reviewed to determine the codes indicating unfitting conditions. Sixty-nine percent of these conditions were orthopaedic. Fifty-seven percent of the injured had unfitting conditions that were orthopaedic only. Of those evacuated from theater with a primary diagnosis of injury to the head, thorax, or abdomen and who suffered an orthopaedic injury as well, 76% had an orthopaedic diagnosis as the primary unfitting condition. Orthopaedic-related disability has a significant impact on the affected patient, the health care system, and, in the case of wounded service members, on military strength and readiness. C1 [Cross, Jessica D.; Hsu, Joseph R.; Wenke, Joseph C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Cross, Jessica D.; Ficke, James R.; Hsu, Joseph R.; Masini, Brendan D.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Cross, JD (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. FU Geneva Foundation; Smith Nephew FX Dr. Ficke or an immediate family member serves as a board member, owner, officer, or committee member of the American Orthopaedic Foot and Ankle Society, the American Academy of Orthopaedic Surgeons, the Society of Military Orthopaedic Surgeons, and the Airlift Research Foundation. Dr. Hsu or an immediate family member has received research or institutional support from The Geneva Foundation and serves as a board member, owner, officer, or committee member of the Society of Military Orthopaedic Surgeons. Dr. Wenke or an immediate family member has received nonincome support (such as equipment or services), commercially derived honoraria, or other non-research related funding (such as paid travel) from Smith & Nephew. Neither of the following authors nor any immediate family member has received anything of value from or owns stock in a commercial company or institution related directly or indirectly to the subject of this article: Dr. Cross and Dr. Masini. NR 14 TC 86 Z9 86 U1 4 U2 19 PU AMER ACAD ORTHOPAEDIC SURGEONS PI ROSEMENT PA 6300 N RIVER ROAD, ROSEMENT, IL 60018-4262 USA SN 1067-151X J9 J AM ACAD ORTHOP SUR JI J. Am. Acad. Orthop. Surg. PY 2011 VL 19 SU 1 BP S1 EP S7 PG 7 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 722IE UT WOS:000287425100002 PM 21304041 ER PT J AU Forsberg, JA Potter, BK Cierny, G Webb, L AF Forsberg, Jonathan Agner Potter, Benjamin Kyle Cierny, George, III Webb, Lawrence TI Diagnosis and Management of Chronic Infection SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS LA English DT Article ID INTRACELLULAR STAPHYLOCOCCUS-AUREUS; LOCAL ANTIBIOTIC-THERAPY; EXPERIMENTAL OSTEOMYELITIS; OPEN FRACTURES; POLYMETHYLMETHACRYLATE BEADS; SURGICAL DEBRIDEMENT; LOWER-EXTREMITY; BONE DEFECTS; IN-VITRO; GENTAMICIN AB High-energy penetrating extremity injuries are often associated with severe open fractures that have varying degrees of soft-tissue contamination and tenuous soft-tissue coverage. The result is a relatively high prevalence of chronic osteomyelitis compared with that in civilian trauma patients. Diagnosing chronic osteomyelitis requires a careful history and thorough physical and radiographic examinations. Cross-sectional imaging can help delineate the extent of bony involvement, and scintigraphy can be used as a diagnostic tool and to gauge response to treatment. Clinical staging also directs surgical management. Adequacy of debridement remains the most important clinical predictor of success; thus, adopting an oncologic approach to complete (ie, wide) excision is important. Reconstruction can be safely performed by a variety of methods; however, proper staging and patient selection remain critical to a successful outcome. Although systemic and depot delivery of antibiotics plays a supporting role in the treatment of chronic osteomyelitis, the ideal dosing regimens, and the duration of treatment, remain controversial. C1 [Forsberg, Jonathan Agner] Mem Sloan Kettering Canc Ctr, Dept Orthopaed Surg, New York, NY 10021 USA. Walter Reed Army Med Ctr, Orthopaed Surg Serv, Washington, DC 20307 USA. [Cierny, George, III] REOrthopaedics, San Diego, CA USA. [Webb, Lawrence] Georgia Orthopaed Trauma Inst, Macon, GA USA. RP Forsberg, JA (reprint author), Mem Sloan Kettering Canc Ctr, Dept Orthopaed Surg, 1275 York Ave, New York, NY 10021 USA. RI Forsberg, Jonathan/K-2116-2012 FU Synthes; Smith Nephew; Stryker; Kinetic Concepts FX Dr. Cierny or an immediate family member has stock or stock options held in Royer Biomedical and serves as a board member, owner, officer, or committee member of the Limb Lengthening and Reconstruction Society and the Musculoskeletal Infection Society. Dr. Webb or an immediate family member is a member of a speakers' bureau or has made paid presentations on behalf of the Musculoskeletal Transplant Foundation; serves as a paid consultant to Zimmer; has received nonincome support (such as equipment or services), commercially derived honoraria, or other non-research related funding (such as paid travel) from Synthes, Smith & Nephew, Stryker, and Kinetic Concepts; and serves as a board member, owner, officer, or committee member of the Orthopaedic Trauma Association Southeastern Fracture Consortium. Neither of the following authors or any immediate family member has received anything of value from or owns stock in a commercial company or institution related directly or indirectly to the subject of this article: Dr. Forsberg and Dr. Potter. NR 86 TC 11 Z9 19 U1 1 U2 2 PU AMER ACAD ORTHOPAEDIC SURGEONS PI ROSEMENT PA 6300 N RIVER ROAD, ROSEMENT, IL 60018-4262 USA SN 1067-151X J9 J AM ACAD ORTHOP SUR JI J. Am. Acad. Orthop. Surg. PY 2011 VL 19 SU 1 BP S8 EP S19 PG 12 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 722IE UT WOS:000287425100003 PM 21304049 ER PT J AU Goff, BJ Castillo, R Raja, SN AF Goff, Brandon J. Castillo, Renan Raja, Srinivasa N. TI Painful Sequelae Following Limb Salvage: Etiology and Management SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS LA English DT Article ID SPINAL-CORD STIMULATION; REFLEX SYMPATHETIC DYSTROPHY; RANDOMIZED CONTROLLED-TRIAL; OPERATION IRAQI-FREEDOM; LOWER-EXTREMITY TRAUMA; SYNDROME TYPE-I; RETROSPECTIVE ANALYSIS; ENDURING FREEDOM; INJURIES; PREVALENCE AB Inadequately controlled pain is a significant problem during limb salvage and is associated with poor outcomes. This pain has several causes, and many management options exist. Chronic pain associated with limb salvage causes unnecessary suffering and negatively affects long-term function. Chronic pain and disability in this population may be prevented with early, aggressive, comprehensive treatment. Ongoing research into the cause and clinical course of limb salvage pain likely will lead to advances in pain management and functional improvement. C1 [Goff, Brandon J.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Outpatient Pain Serv, Ft Sam Houston, TX 78234 USA. [Castillo, Renan] Johns Hopkins Univ, Sch Publ Hlth, Baltimore, MD USA. [Raja, Srinivasa N.] Johns Hopkins Univ, Sch Med, Dept Anesthesiol & Crit Care Med, Div Pain Med, Baltimore, MD 21205 USA. RP Goff, BJ (reprint author), Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Outpatient Pain Serv, Ft Sam Houston, TX 78234 USA. NR 44 TC 3 Z9 3 U1 4 U2 4 PU AMER ACAD ORTHOPAEDIC SURGEONS PI ROSEMENT PA 6300 N RIVER ROAD, ROSEMENT, IL 60018-4262 USA SN 1067-151X J9 J AM ACAD ORTHOP SUR JI J. Am. Acad. Orthop. Surg. PY 2011 VL 19 SU 1 BP S23 EP S27 PG 5 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 722IE UT WOS:000287425100005 PM 21304043 ER PT J AU Grogan, BF Hsu, JR AF Grogan, Brian F. Hsu, Joseph R. CA Skeletal Trauma Res Consortium TI Volumetric Muscle Loss SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS LA English DT Article ID OPERATION ENDURING FREEDOM; IRAQI FREEDOM; STEM-CELLS; RELIABILITY AB Prevention of infection, as well as bone covering and healing, is paramount in the management of limb injury with associated muscle injury. Volumetric muscle loss (VML) is the traumatic or surgical loss of skeletal muscle with resultant functional impairment. No standardized evaluation protocol exists for the characterization and quantification of VML. Clinical photographs and video recordings, range of motion measurements, manual muscle strength testing, and isokinetic muscle function testing may prove to be useful in documenting VML. Current treatment options include functional free muscle transfer and the use of advanced bracing designs. Advances in powered bracing and regenerative medicine may one day provide additional therapeutic options. Further research on VML is warranted. C1 [Grogan, Brian F.] Brooke Army Med Ctr, San Antonio Uniformed Serv Hlth Educ Consortium, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. [Hsu, Joseph R.] Brooke Army Med Ctr, USA, Inst Surg Res, San Antonio Uniformed Serv Hlth Educ Consortium, Ft Sam Houston, TX 78234 USA. RP Grogan, BF (reprint author), Brooke Army Med Ctr, San Antonio Uniformed Serv Hlth Educ Consortium, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. FU Geneva Foundation FX Dr. Hsu or an immediate family member serves as a board member, owner, officer, or committee member of the Society of Military Orthopaedic Surgeons and has received research or institutional support from the Geneva Foundation. Neither Dr. Grogan nor any immediate family member has received anything of value from or owns stock in a commercial company or institution related directly or indirectly to the subject of this article. NR 20 TC 65 Z9 65 U1 5 U2 14 PU AMER ACAD ORTHOPAEDIC SURGEONS PI ROSEMENT PA 6300 N RIVER ROAD, ROSEMENT, IL 60018-4262 USA SN 1067-151X J9 J AM ACAD ORTHOP SUR JI J. Am. Acad. Orthop. Surg. PY 2011 VL 19 SU 1 BP S35 EP S37 PG 3 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 722IE UT WOS:000287425100007 PM 21304045 ER PT J AU Wenke, JC Milutinovich, AB Pollak, AN AF Wenke, Joseph C. Milutinovich, Allison B. Pollak, Andrew N. TI Congressionally Directed Research Will Improve Outcomes Through Funding Opportunities for Orthopaedics SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS LA English DT Article ID OPERATION ENDURING FREEDOM; IRAQI FREEDOM AB The large funding opportunities created by the US Congress have allowed the military and civilian orthopaedic communities to collaborate to define clinical problems and develop solutions. It is believed that this research effort will be constructive in the short term because of emphasis placed on funding projects that used relevant populations and approaches that will benefit patients soon. The immediate results will define best practice guidelines. Additionally, new therapies will be fielded that will reduce complications and improve the outcomes of both injured service personnel and civilians. C1 [Wenke, Joseph C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Milutinovich, Allison B.] USA, Med Res & Mat Command, Congressionally Directed Med Res Programs, Ft Detrick, MD USA. [Pollak, Andrew N.] Univ Maryland, Sch Med, R Adams Cowley Shock Trauma Ctr, Baltimore, MD 21201 USA. RP Wenke, JC (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. FU Smith Nephew; Stryker FX Dr. Wenke or an immediate family member has received nonincome support (such as eguipment or services), commercially derived honoraria, or other non-research related funding (such as paid travel) from Smith & Nephew. Dr. Pollak or an immediate family member has received royalties from ExtraOrtho; is a member of a speakers' bureau or has made paid presentations on behalf of KCI; serves as a paid consultant to Smith & Nephew; has received research or institutional support from Smith & Nephew and Stryker; has received royalties from the American Academy of Orthopaedic Surgeons; and serves as a board member, owner, officer, or committee member of the National Trauma Institute and the Orthopaedic Trauma Association. Neither Dr. Milutinovich nor any immediate family member has received anything of value from or owns stock in a commercial company or institution related directly or indirectly to the subject of this article. NR 5 TC 4 Z9 4 U1 1 U2 1 PU AMER ACAD ORTHOPAEDIC SURGEONS PI ROSEMENT PA 6300 N RIVER ROAD, ROSEMENT, IL 60018-4262 USA SN 1067-151X J9 J AM ACAD ORTHOP SUR JI J. Am. Acad. Orthop. Surg. PY 2011 VL 19 SU 1 BP S40 EP S43 PG 4 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 722IE UT WOS:000287425100009 PM 21304047 ER PT J AU Payne, KS Novak, JJ Jongsakul, K Imerbsin, R Apisitsaowapa, Y Pavlin, JA Hinds, SB AF Payne, Kevin S. Novak, Joseph J. Jongsakul, Krisada Imerbsin, Rawiwan Apisitsaowapa, Yinglak Pavlin, Julie A. Hinds, Sarah B. TI Mycobacterium tuberculosis Infection in a Closed Colony of Rhesus Macaques (Macaca mulatta) SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE LA English DT Article ID NONHUMAN-PRIMATES; MONKEYS; BOVIS AB Mycobacterium infections in nonhuman primates can devastate the colonies and place human handlers at risk. Despite conservative measures to prevent exposure, infections occur even in closed colonies. Here we describe a recent case of M. tuberculosis within a closed colony of rhesus macaques at our Thailand facility and the procedures instituted to prevent subsequent infections. Investigation of the outbreak did not confirm the source of the infection, but even with intensive occupational safety measures in place, human contact remains the most likely possibility. C1 [Payne, Kevin S.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Novak, Joseph J.; Jongsakul, Krisada; Imerbsin, Rawiwan; Apisitsaowapa, Yinglak; Pavlin, Julie A.; Hinds, Sarah B.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Pavlin, JA (reprint author), Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. EM julie.pavlin@us.army.mil NR 19 TC 9 Z9 10 U1 0 U2 0 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1559-6109 J9 J AM ASSOC LAB ANIM JI J. Amer. Assoc. Lab. Anim. Sci. PD JAN PY 2011 VL 50 IS 1 BP 105 EP 108 PG 4 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 716XV UT WOS:000287007700015 PM 21333172 ER PT J AU Knudson, MM Cohen, MJ Reidy, R Jaeger, S Bacchetti, P Jin, CS Wade, CE Holcomb, JB AF Knudson, M. Margaret Cohen, Mitchell J. Reidy, Rosemary Jaeger, Sebastian Bacchetti, Peter Jin, Chengshi Wade, Charles E. Holcomb, John B. TI Trauma, Transfusions, and Use of Recombinant Factor VIIa: A Multicenter Case Registry Report of 380 Patients from the Western Trauma Association SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Article ID ACTIVATED FACTOR-VII; MASSIVE TRANSFUSION; ADJUNCTIVE THERAPY; DAMAGE CONTROL; COAGULOPATHY; BLOOD; THROMBOEMBOLISM; REQUIREMENTS; HEMORRHAGE; MORTALITY AB BACKGROUND: This study describes the current use of recombinant activated factor VII (rFVIIa) for hemorrhage after trauma in the United States. We hypothesized that we could describe the setting in which rFVIIa would be most successful in arresting hemorrhage after injury. STUDY DESIGN: This case registry study of patients with traumatic injuries at risk for death from hemorrhage at Level I and II trauma centers in the United States analyzed the administration of rFVIIa from admission to death from hemorrhage. Secondary outcomes measures of interest were the use of blood products, days in the ICU, organ failure, and thrombotic complications. RESULTS: Three hundred and eighty injured patients who received rEVIIa as an adjunct for hemorrhage control were included in this analysis. The mean time from admission to administration of rFVIIa was 4.6 hours, with an average transfusion of 18 U blood before administration (range 0 to 99 U). Death from hemorrhage rate was 30%. Predictors of a poor response to rFVIIa were a pH <7.2 (p < 0.0001), a platelet count <100,000 (p = 0.046), and blood pressure <= 90 mmHg (p < 0.0001) at the time of administration. CONCLUSIONS: Based on this case registry review, the precise role of rFVIIa in traumatic hemorrhage is unclear. Surgeons choosing to use this drug as an adjunctive measure to reverse coagulopathy are advised to first correct shock, acidosis, and thrombocytopenia. Am Coll Surg 2011;212:87-95. (C) 2011 by the American College of Surgeons) C1 [Knudson, M. Margaret; Cohen, Mitchell J.; Reidy, Rosemary; Jaeger, Sebastian] Univ Calif San Francisco, Dept Surg, San Francisco, CA 94143 USA. [Bacchetti, Peter; Jin, Chengshi] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA. [Wade, Charles E.] USA, Inst Surg Res, Houston, TX USA. [Holcomb, John B.] Univ Texas Hlth Sci Ctr, Dept Surg, Houston, TX USA. RP Knudson, MM (reprint author), San Francisco Gen Hosp, Dept Surg, Ward 3A,1001 Potrero Ave, San Francisco, CA 94110 USA. EM pknkudson@sfghsurg.ucsf.edu FU Novo Nordisk Pharmaceuticals Inc.; Novo Nordisk Pharmaceuticals FX This work was supported by a grant to the Western Trauma Association Foundation from Novo Nordisk Pharmaceuticals Inc. Dr Knudson is the principal investigator for and received research grant support from Novo Nordisk Pharmaceuticals. All other authors have nothing to disclose. NR 31 TC 19 Z9 23 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD JAN PY 2011 VL 212 IS 1 BP 87 EP 95 DI 10.1016/j.jamcollsurg.2010.08.020 PG 9 WC Surgery SC Surgery GA 705LE UT WOS:000286129100011 PM 21115374 ER PT J AU Muramatsu, RS Goebert, D AF Muramatsu, Russ S. Goebert, Deborah TI Psychiatric Services: Experience, Perceptions, and Needs of Nursing Facility Multidisciplinary Leaders SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Article DE psychiatry; nursing facility; health services ID MENTAL-HEALTH-SERVICES; LONG-TERM-CARE; GERIATRIC PSYCHIATRY; HOMES; PROVISION; STAFF; DEPRESSION; DISORDERS; CONFUSION; NURSES AB OBJECTIVES To identify the experience and perceptions of multidisciplinary nursing facility leaders regarding need for psychiatric services in residents of long-term care. DESIGN Cross-sectional study. SETTING Nursing facilities in Hawaii. PARTICIPANTS Surveys were sent to 188 nursing facility administrators, medical directors, directors of nursing, and directors of social work at 47 facilities in Hawaii; 99 individual staff responses (52% response rate) were received from 42 facilities (89% response rate). MEASUREMENTS Educational experience, psychiatric service perceptions, and needs as assessed by survey questions. RESULTS The most commonly cited reasons for not accepting a patient with a recent history of or current psychiatric or behavioral problems were concerns of dangerousness (73.5%), the need for greater staff attention (64.3%), and difficulty accessing psychiatric support and follow-up after admission (53.1%). Easy accessibility (66.3%) was the most essential consultant quality, and pharmacological treatment interventions (88.4%) were deemed most helpful. Behavioral management of dementia (93.6%) was the most requested educational topic, followed by depression and suicide (77.7%). There were some differences noted between specialties. CONCLUSION The findings highlight the unmet needs of nursing facility leaders, gives direction to and reinforces how psychiatrists, by virtue of their training and skills, can play a central role in meeting these needs, and offer a glimpse of the potential for collaboration to addresses the mental health and psychiatric service needs of the long-term care residents. C1 [Muramatsu, Russ S.] Tripler Army Med Ctr, Dept Psychiat, Honolulu, HI 96859 USA. [Goebert, Deborah] Univ Hawaii, John A Burns Sch Med, Dept Psychiat, Honolulu, HI 96822 USA. RP Muramatsu, RS (reprint author), Tripler Army Med Ctr, Dept Psychiat, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM russ.muramatsu@amedd.army.mil FU University of Hawaii, Department of Psychiatry FX Financial support provided by the University of Hawaii, Department of Psychiatry. NR 26 TC 2 Z9 2 U1 1 U2 8 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0002-8614 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD JAN PY 2011 VL 59 IS 1 BP 120 EP 125 DI 10.1111/j.1532-5415.2010.03205.x PG 6 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA 706HG UT WOS:000286208200018 PM 21158745 ER PT J AU Laoire, CO Mukerjee, S Plichta, EJ Hendrickson, MA Abraham, KM AF Laoire, Cormac O. Mukerjee, Sanjeev Plichta, Edward J. Hendrickson, Mary A. Abraham, K. M. TI Rechargeable Lithium/TEGDME-LiPF6/O-2 Battery SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID LITHIUM/OXYGEN BATTERY; POLYMER ELECTROLYTE AB A rechargeable Li-air cell utilizing an electrolyte composed of a solution of LiPF6 in tetraethylene glycol dimethyl ether, CH3O(CH2CH2O)(4)CH3 (TEGDME), and an uncatalyzed porous carbon electrode, investigated to elucidate the baseline Li-air battery chemistry, is reported. From the x-ray diffraction patterns of the discharged carbon electrodes, the discharge product of the cell was identified to be Li2O2 during normal discharge to 1.5 V. Discharging the cell to 1.0 V or below produces Li2O as well. The cell can be recharged without a catalyst in the carbon cathode, albeit at low depths of discharge. The high resistance of the discharged carbon cathode is a major impediment to recharging cells displaying a high specific capacity. The cell capacity decreases with continued cycling, which was found to be due to the poor cycling efficiency of the Li anode and the high resistance of the discharge products, which slowly accumulate in the porous electrode. (C) 2011 The Electrochemical Society. [DOI:10.1149/1.3531981] All rights reserved. C1 [Laoire, Cormac O.; Mukerjee, Sanjeev; Abraham, K. M.] Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA. [Plichta, Edward J.; Hendrickson, Mary A.] USA, CERDEC, Army Power Div, Ft Monmouth, NJ 07703 USA. RP Laoire, CO (reprint author), Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA. EM kmabraham@comcast.net FU US Army CERDEC [GTS-S-6-1-437] FX US Army CERDEC through Subcontract no. GTS-S-6-1-437 supported this work. NR 15 TC 282 Z9 284 U1 10 U2 157 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 SOUTH MAIN STREET, PENNINGTON, NJ 08534 USA SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PY 2011 VL 158 IS 3 BP A302 EP A308 DI 10.1149/1.3531981 PG 7 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA 712PE UT WOS:000286677900016 ER PT J AU Read, J Collins, E Piekarski, B Zhang, S AF Read, Jeffrey Collins, Evan Piekarski, Brandon Zhang, Sheng TI LiF Formation and Cathode Swelling in the Li/CFx Battery SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID DISCHARGE REACTION; LITHIUM BATTERIES; MECHANISM; ELECTRODE AB The Li/CFx cell has been traditionally used for low rate applications at discharge rates of C/1000 or lower. The development of cells capable of operating at discharge rates closer to C/10 is underway for communication applications. The Li/CFx cell is known to produce a significant amount of thermal power during high rate discharge and cathode swelling that can result in mechanical deformation of the cell. Previously, we characterized the thermal power during discharge in both coin cells and large format cells and proposed that the discharge is a two phase reaction with the direct formation of LiF. In this paper we measure the mechanical cathode swelling as a function of discharge depth, rate, and temperature. Discharged cathodes are then characterized using X-ray diffraction, scanning electron microscopy, and N-2 adsorption surface area measurements. These results support a mechanism where the discharge product is LiF deposited on the internal surfaces of the carbon layers left behind after electrochemical reduction with this deposition leading directly to the measured cathode swelling. The recrystallization of LiF observed by X-ray diffraction over a period of days results in a long time constant thermal power that can be measured after discharge in large format cells. (C) 2011 The Electrochemical Society. [DOI: 10.1149/1.3561429] All rights reserved. C1 [Read, Jeffrey; Collins, Evan; Piekarski, Brandon; Zhang, Sheng] USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA. RP Read, J (reprint author), USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA. EM jread@arl.army.mil RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 26 TC 15 Z9 16 U1 2 U2 41 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 SOUTH MAIN STREET, PENNINGTON, NJ 08534 USA SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PY 2011 VL 158 IS 5 BP A504 EP A510 DI 10.1149/1.3561429 PG 7 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA 741ML UT WOS:000288867700010 ER PT J AU Siegel, JB Lin, XF Stefanopoulou, AG Hussey, DS Jacobson, DL Gorsich, D AF Siegel, Jason B. Lin, Xinfan Stefanopoulou, Anna G. Hussey, Daniel S. Jacobson, David L. Gorsich, David TI Neutron Imaging of Lithium Concentration in LFP Pouch Cell Battery SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID ION BATTERIES; RADIOGRAPHY; DETECTORS; PEMFC AB This paper shows how neutron radiography can be used for in situ quantification of the lithium concentration across battery electrodes, a critical physical system state. The change in lithium concentration between the charged and discharged states of the battery causes a change in number of detected neutrons after passing through the battery. Electrode swelling is also observed during battery charging. The experimental setup and the observations from testing a pouch cell with LFP cathode and graphite anode are reported here. The bulk Li concentration across the electrode and folds of the pouch cell is quantified at various states of charge. To interpret the measurements, the optics of the neutron beam (geometric unsharpness) and detector resolution are considered in order to quantify the lithium concentration from the images due to the thinness of the electrode layers. The experimental methodology provides a basis for comprehensive in situ metrology of bulk lithium concentration. (C) 2011 The Electrochemical Society. [DOI: 10.1149/1.3566341] All rights reserved. C1 [Siegel, Jason B.; Lin, Xinfan; Stefanopoulou, Anna G.] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. [Hussey, Daniel S.; Jacobson, David L.] Natl Inst Stand & Technol, Phys Measurements Lab, Gaithersburg, MD 20899 USA. [Gorsich, David] USA, Tank Automot Res Dev & Engn Ctr TARDEC, Warren, MI 48397 USA. RP Siegel, JB (reprint author), Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. EM siegeljb@umich.edu RI Sanders, Susan/G-1957-2011; OI Siegel, Jason/0000-0003-2824-013X FU Ford Motor Company (Ford); Automotive Research Center (ARC) FX The authors thank Dr. Ding from TARDEC; Patrick Hagan, Maha Hammoud, and Danny King from A123 systems; Eli Baltic from the NIST Physical Measurement Laboratory; and Levi Thompson, Xiaohui Chen, Binay Prasad, Sun Bo Hwang, and Saemin Choi from the University of Michigan. We acknowledge the support of the National Institute of Standards and Technology, U. S. Department of Commerce, in providing the neutron research facilities used in this work. This work has been partially supported by the Ford Motor Company (Ford/UMICH Alliance Project) and by the Automotive Research Center (ARC) a U.S. Army center of excellence in modeling and simulation of ground vehicles. NR 20 TC 50 Z9 50 U1 1 U2 45 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 SOUTH MAIN STREET, PENNINGTON, NJ 08534 USA SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PY 2011 VL 158 IS 5 BP A523 EP A529 DI 10.1149/1.3566341 PG 7 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA 741ML UT WOS:000288867700013 ER PT J AU von Cresce, A Xu, K AF von Cresce, Arthur Xu, Kang TI Electrolyte Additive in Support of 5 V Li Ion Chemistry SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID ELECTROCHEMICAL PROPERTIES; SPINEL CATHODES; PHOSPHORIC-ACID; BATTERIES; SURFACE; CELLS; SULFONE; CARBONATE; SOLVENT; STEEL AB An electrolyte additive based on highly fluorinated phosphate ester structure was identified as being able to stabilize carbonate-based electrolytes on 5 V class cathode surfaces. The synthesis and structural analysis of the additive are described, and preliminary yet encouraging results from electrochemical characterization showed that this additive participates in forming a protective interphasial chemistry not only on transition metal oxide cathode at high voltage (similar to 5 V vs Li) but also on graphitic graphite at low voltage (similar to 0 V vs Li), making it possible to formulate an electrolyte supporting reversible Li+-intercalation chemistry in the coveted 5 V region. (C) 2011 The Electrochemical Society. [DOI:10.1149/1.3532047] All rights reserved. C1 [von Cresce, Arthur; Xu, Kang] USA, Electrochem Branch, Power & Energy Div, Sensor & Electron Devices Directorate,Res Lab, Adelphi, MD 20783 USA. RP von Cresce, A (reprint author), USA, Electrochem Branch, Power & Energy Div, Sensor & Electron Devices Directorate,Res Lab, Adelphi, MD 20783 USA. EM cxu@arl.army.mil RI Cresce, Arthur/K-3958-2013 OI Cresce, Arthur/0000-0002-3894-6083 FU Department of Energy Advanced Battery Research (DOE-ABR) FX This project was partially funded by Department of Energy Advanced Battery Research (DOE-ABR) Program. The authors thank Professor Amatucci of Rutgers University for providing cathode materials samples, and Dr. Yiufai Lam and Dr. Yue Li for providing NMR services and Mass Spectrum Services, respectively. NR 36 TC 79 Z9 79 U1 8 U2 88 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 SOUTH MAIN STREET, PENNINGTON, NJ 08534 USA SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PY 2011 VL 158 IS 3 BP A337 EP A342 DI 10.1149/1.3532047 PG 6 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA 712PE UT WOS:000286677900021 ER PT J AU Zhang, GQ Zheng, JP Liang, R Zhang, C Wang, B Au, M Hendrickson, M Plichta, EJ AF Zhang, G. Q. Zheng, J. P. Liang, R. Zhang, C. Wang, B. Au, M. Hendrickson, M. Plichta, E. J. TI alpha-MnO2/Carbon Nanotube/Carbon Nanofiber Composite Catalytic Air Electrodes for Rechargeable Lithium-air Batteries SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID ORGANIC ELECTROLYTE; LI/AIR BATTERIES; ION BATTERIES; CATHODE AB Air electrodes, made with a mixture of carbon nanotube (CNT)/carbon nanofiber (CNF) and with/without alpha-MnO2 nano-rods, were prepared for Li-air cells. The charge capacity and cyclability were found to increase largely for the cells made with the alpha-MnO2 catalyst; however, the first cycle discharge capacities were no different for the cells made with and without the alpha-MnO2 catalyst. It was found that the discharge capacity of the Li-air cell was mainly due to oxygen deficiency from the pinch-off of the diffusion channel by the deposition product at the air side of the air electrode. Electrochemical impedance spectra at different cycles demonstrated that the charge transfer resistance was increased and decreased during discharge and charge processes, respectively, due to the change of porosity, oxygen concentration, and rate of coefficient of chemical reaction in the air electrode. (C) 2011 The Electrochemical Society. [DOI: 10.1149/1.3590736] All rights reserved. C1 [Zhang, G. Q.; Zheng, J. P.] Florida A&M Univ, Dept Elect & Comp Engn, Tallahassee, FL 32310 USA. [Liang, R.; Zhang, C.; Wang, B.] Florida A&M Univ, Dept Ind & Mfg Engn, Tallahassee, FL 32310 USA. [Zheng, J. P.] Florida State Univ, Ctr Adv Power Syst, Tallahassee, FL 32310 USA. [Liang, R.; Zhang, C.; Wang, B.] Florida State Univ, High Performance Mat Inst, Tallahassee, FL 32310 USA. [Au, M.] Savannah River Natl Lab, Aiken, SC 29808 USA. [Hendrickson, M.; Plichta, E. J.] USA, Power Div, Army CERDEC, Ft Monmouth, NJ 07703 USA. RP Zhang, GQ (reprint author), Florida A&M Univ, Dept Elect & Comp Engn, Tallahassee, FL 32310 USA. EM zheng@eng.fsu.edu RI zhang, guoqing/G-7798-2011 OI zhang, guoqing/0000-0001-5896-0483 FU US Army-CERDEC; Savannah River National Laboratory FX This work was supported by US Army-CERDEC and Savannah River National Laboratory. NR 20 TC 91 Z9 96 U1 15 U2 172 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 SOUTH MAIN STREET, PENNINGTON, NJ 08534 USA SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PY 2011 VL 158 IS 7 BP A822 EP A827 DI 10.1149/1.3590736 PG 6 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA 767QI UT WOS:000290870700008 ER PT J AU Zheng, JP Andrei, P Hendrickson, M Plichta, EJ AF Zheng, J. P. Andrei, P. Hendrickson, M. Plichta, E. J. TI The Theoretical Energy Densities of Dual-Electrolytes Rechargeable Li-Air and Li-Air Flow Batteries SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID LITHIUM/OXYGEN BATTERY; O-2 AB The theoretical energy densities of dual-electrolytes rechargeable Li-air batteries using a nonaqueous electrolyte in the anode and an aqueous electrolyte in the cathode are estimated based on the electrochemical reaction mechanisms and the solubility of the discharge product. It is assumed that there is no solid deposition in a cathode during discharge. A number of basic and acidic electrolytes with high solubility of the discharge product are proposed. The theoretical energy densities of these rechargeable Li-air batteries vary from 140 to over 1100 Wh/kg depending on the type of the electrolytes in a cathode. A few structures of Li-air flow battery systems for possible large scale applications are also proposed. (C) 2010 The Electrochemical Society. [DOI: 10.1149/1.3515330] All rights reserved. C1 [Zheng, J. P.; Andrei, P.] Florida A&M Univ, Dept Elect & Comp Engn, Tallahassee, FL 32310 USA. [Zheng, J. P.; Andrei, P.] Florida State Univ, Tallahassee, FL 32310 USA. [Zheng, J. P.] Florida State Univ, Ctr Adv Power Syst, Tallahassee, FL 32310 USA. [Hendrickson, M.; Plichta, E. J.] USA, Power Div, Army CERDEC, Ft Monmouth, NJ 07703 USA. RP Zheng, JP (reprint author), Florida A&M Univ, Dept Elect & Comp Engn, Tallahassee, FL 32310 USA. EM zheng@eng.fsu.edu FU National Sciences Foundation under Engineering Research Center [EEC-0812121]; U.S. Army CERDEC FX The work was supported by National Sciences Foundation under Engineering Research Center Program no. EEC-0812121 and U.S. Army CERDEC. NR 13 TC 31 Z9 33 U1 6 U2 47 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 SOUTH MAIN STREET, PENNINGTON, NJ 08534 USA SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PY 2011 VL 158 IS 1 BP A43 EP A46 DI 10.1149/1.3515330 PG 4 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA 686LN UT WOS:000284697900006 ER PT J AU Vasterling, JJ Proctor, SP AF Vasterling, Jennifer J. Proctor, Susan P. TI Understanding the Neuropsychological Consequences of Deployment Stress: A Public Health Framework SO JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY LA English DT Review DE Deployment; Stress; Neuropsychological functioning; Public health; Epidemiology; Veterans; Military personnel ID PERSIAN-GULF-WAR; TWINS DISCORDANT; MENTAL-HEALTH; IRAQ-WAR; VETERANS; DISORDER; PTSD; MEMORY; SYMPTOMS; SOLDIERS AB Complaints of neuropsychological dysfunction have emerged among subsets of military personnel after almost every major deployment involving western nations in recent history. Although deployments have been characterized by a range of neural risk factors, psychological stress is common to most prolonged deployments. This review uses a public health framework to address associations between deployment-related stress and neuropsychological performance. Specifically, the review covers mechanisms by which deployment-related psychological stress may affect neuropsychological functioning, considers the advantages and disadvantages of approaching the question from a public health perspective, and discusses how epidemiological research may sort out questions regarding course, cause, and effect. (JINS, 2011, 17,1-6) C1 [Vasterling, Jennifer J.] VA Boston Healthcare Syst, Psychol Serv, Boston, MA 02130 USA. [Vasterling, Jennifer J.] VA Boston Healthcare Syst, PTSD, VA Natl Ctr, Boston, MA 02130 USA. [Vasterling, Jennifer J.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA. [Proctor, Susan P.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Proctor, Susan P.] VA Boston Healthcare Syst, Res Serv, Boston, MA 02130 USA. [Proctor, Susan P.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. RP Vasterling, JJ (reprint author), VA Boston Healthcare Syst, Psychol Serv, Psychol 116,150 S Huntington Ave, Boston, MA 02130 USA. EM jennifer.vasterling@va.gov NR 43 TC 7 Z9 7 U1 1 U2 4 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1355-6177 J9 J INT NEUROPSYCH SOC JI J. Int. Neuropsychol. Soc. PD JAN PY 2011 VL 17 IS 1 BP 1 EP 6 DI 10.1017/S1355617710001116 PG 6 WC Clinical Neurology; Neurosciences; Psychiatry; Psychology SC Neurosciences & Neurology; Psychiatry; Psychology GA 702KX UT WOS:000285894700001 PM 21083962 ER PT J AU Pervin, F Chen, WNW Weerasooriya, T AF Pervin, Farhana Chen, Weinong W. Weerasooriya, Tusit TI Dynamic compressive response of bovine liver tissues SO JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS LA English DT Article DE Kolsky bar; Mechanical response; Liver tissue; Strain rate effect ID HOPKINSON PRESSURE BAR; MECHANICAL CHARACTERIZATION; VISCOELASTIC PROPERTIES; SOFT MATERIALS; PORCINE LIVER; IN-VIVO; INDENTATION; CAPSULE; TRAUMA; INJURY AB This study aims to experimentally determine the strain rate effects on the compressive stress-strain behavior of bovine liver tissues. Fresh liver tissues were used to make specimens for mechanical loading. Experiments at quasi-static strain rates were conducted at 0.01 and 0.1 s(-1). Intermediate-rate experiments were performed at 1, 10, and 100 s(-1). High strain rate (1000, 2000, and 3000 s(-1)) experiments were conducted using a Kolsky bar modified for soft material characterization. A hollow transmission bar with semi-conductor strain gages was used to sense the weak forces from the soft specimens. Quartz-crystal force transducers were used to monitor valid testing conditions on the tissue specimens. The experiment results show that the compressive stress-strain response of the liver tissue is non-linear and highly rate-sensitive, especially when the strain rate is in the Kolsky bar range. The tissue stiffens significantly with increasing strain rate. The responses from liver tissues along and perpendicular to the liver surface were consistent, indicating isotropic behavior. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Pervin, Farhana; Chen, Weinong W.] Purdue Univ, Sch Aeronaut Astronaut, W Lafayette, IN 47907 USA. [Pervin, Farhana; Chen, Weinong W.] Purdue Univ, Sch Mat Engn, W Lafayette, IN 47907 USA. [Weerasooriya, Tusit] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Chen, WNW (reprint author), Purdue Univ, Sch Aeronaut Astronaut, W Lafayette, IN 47907 USA. EM wchen@purdue.edu FU US Army Research Laboratory; Purdue University FX This research was supported by a Collaborative Agreement between US Army Research Laboratory and Purdue University. The author would like to acknowledge the Animal Science Department at Purdue University for providing the fresh bovine liver. NR 42 TC 13 Z9 13 U1 3 U2 23 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1751-6161 J9 J MECH BEHAV BIOMED JI J. Mech. Behav. Biomed. Mater. PD JAN PY 2011 VL 4 IS 1 BP 76 EP 84 DI 10.1016/j.jmbbm.2010.09.007 PG 9 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA 705KD UT WOS:000286126400008 PM 21094481 ER PT J AU Dutra, L Grubbs, K Greene, C Trego, LL McCartin, TL Kloezeman, K AF Dutra, Lissa Grubbs, Kathleen Greene, Carolyn Trego, Lori L. McCartin, Tamarin L. Kloezeman, Karen TI Women at War: Implications for Mental Health SO JOURNAL OF TRAUMA & DISSOCIATION LA English DT Article DE posttraumatic stress disorder; combat; veterans; parenting; attachment ID POSTTRAUMATIC-STRESS-DISORDER; SEXUAL ASSAULT; VETERANS; PTSD; SYMPTOMS; MILITARY; DEPRESSION; COMBAT; RISK; IRAQ AB Few studies have investigated the impact of deployment stressors on the mental health outcomes of women deployed to Iraq in support of Operation Iraqi Freedom. This pilot study examined exposure to combat experiences and military sexual harassment in a sample of 54 active duty women and assessed the impact of these stressors on post-deployment posttraumatic stress disorder (PTSD) symptoms and depressive symptoms. Within 3 months of returning from deployment to Iraq, participants completed (a) the Combat Experiences Scale and the Sexual Harassment Scale of the Deployment Risk and Resilience Inventory, (b) the Primary Care PTSD Screen, and (c) an abbreviated version of the Center for Epidemiological Studies-Depression scale. Approximately three quarters of the sample endorsed exposure to combat experiences, and more than half of the sample reported experiencing deployment-related sexual harassment, with nearly half of the sample endorsing both stressors. Approximately one third of the sample endorsed clinical or subclinical levels of PTSD symptoms, with 11% screening positive for PTSD and 9% to 14% of the sample endorsing depressive symptoms. Regression analyses revealed that combat experiences and sexual harassment jointly accounted for significant variance in post-deployment PTSD symptoms, whereas military sexual harassment was identified as the only unique significant predictor of these symptoms. Findings from the present study lend support to research demonstrating that military sexual trauma may be more highly associated with post-deployment PTSD symptoms than combat exposure among female service members and veterans. C1 [Dutra, Lissa] VA Boston Healthcare Syst, Natl Ctr Posttraumat Stress Disorder, Womens Hlth Sci Div, Boston, MA USA. [Grubbs, Kathleen; Kloezeman, Karen] Univ Hawaii, Dept Psychol, Honolulu, HI 96822 USA. [Grubbs, Kathleen; Greene, Carolyn; Kloezeman, Karen] Pacific Islands VA Hlth Care Syst, Natl Ctr Posttraumat Stress Disorder, Pacific Islands Div, Honolulu, HI USA. [Greene, Carolyn] VA Palo Alto Hlth Care Syst, Natl Ctr Posttraumat Stress Disorder, Educ Div, Palo Alto, CA USA. [Trego, Lori L.] Tripler Army Med Ctr, Nursing Res Serv, Tripler, HI USA. [McCartin, Tamarin L.] Tripler Army Med Ctr, Dept Obstet & Gynecol, Tripler, HI USA. RP Dutra, L (reprint author), Natl Ctr Posttraumat Stress Disorder 116B 5, Womens Hlth Sci Div, 150 S Huntington Ave, Boston, MA 02130 USA. EM lissamdutra@gmail.com RI Schueter, nicos/A-3625-2014 NR 25 TC 31 Z9 31 U1 0 U2 16 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1529-9732 J9 J TRAUMA DISSOCIATIO JI J. Trauma Dissociation PY 2011 VL 12 IS 1 BP 25 EP 37 DI 10.1080/15299732.2010.496141 PG 13 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 733LG UT WOS:000288263600003 PM 21240736 ER PT J AU DuBose, JJ Barmparas, G Inaba, K Stein, DM Scalea, T Cancio, LC Cole, J Eastridge, B Blackbourne, L AF DuBose, Joseph J. Barmparas, Gallinos Inaba, Kenji Stein, Deborah M. Scalea, Tom Cancio, Leopoldo C. Cole, John Eastridge, Brian Blackbourne, Lorne TI Isolated Severe Traumatic Brain Injuries Sustained During Combat Operations: Demographics, Mortality Outcomes, and Lessons to be Learned From Contrasts to Civilian Counterparts SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 69th Annual Meeting of the American-Association-for-the-Surgery-of-Trauma CY SEP 22-25, 2010 CL Boston, MA SP Amer Assoc Surg Trauma (AAST) DE Severe traumatic brain injury; Combat; Civilian; Outcomes ID RECEIVING MASSIVE TRANSFUSIONS; DECOMPRESSIVE CRANIECTOMY; CENTER DESIGNATION; PLASMA; GUIDELINES; MANAGEMENT; SURVIVAL; MODERATE; RATIO AB Background: Severe traumatic brain injuries occurring in the context of modern military conflict are entities about which little has been reported. We reviewed the epidemiology of these injuries from the Joint Trauma Theater Registry (JTTR), contrasting these results with civilian counterparts from the National Trauma Databank (NTDB). Methods: Isolated severe brain injuries (defined as head abbreviated injury scale [AIS] >= 3 and no other body region AIS >2) were queried from the JTTR over a period from 2003 to 2007. The demographics and outcomes of these injuries were reviewed. These results were then contrasted to findings of similar patients, age 18 years to 55 years, over the same period from the NTDB using propensity score matching derived from age, gender, systolic blood pressure, Glasgow Coma Scale, and AIS. Results: JTTR review identified 604 patients meeting study criteria, with a mean age of 25.7 years. Glasgow Coma Scale was <8 in 27.8%, and 98.0% were men. Hypotension at presentation was noted in 5.5%. Blast (61.9%) and gunshot wound (19.5%) mechanisms accounted for the majority of combat injuries. Intracranial pressure monitoring was used in 15.2%, and 27.0% underwent some form of operative cranial decompression, lobectomy, or debridement. When compared with matched civilian NTDB counterparts, JTTR patients were significantly more likely to undergo intracranial pressure monitoring (13.8% vs. 1.7%; p < 0.001) and operative neurosurgical intervention (21.5% vs. 7.2%; p < 0.001). Mortality was also significantly better among military casualties overall (7.7% vs. 21.0%; p < 0.001; odds ratio, 0.32 [0.16-0.61]) and particularly after penetrating mechanisms of injury (5.6% vs. 47.9%; p < 0.001; odds ratio, 0.07 [0.02-0.20]) compared with propensity score-matched NTDB counterparts. Conclusion: Patients sustaining severe traumatic brain injury during military operations represent a unique population. Comparison with civilian counterparts has inherent limitations but reveals higher rates of neurosurgical intervention performed after penetrating injuries and a corresponding improvement in survival. Many factors likely contribute to these findings, which highlight the need for additional research on the optimal management of penetrating brain injury. C1 [DuBose, Joseph J.; Stein, Deborah M.; Scalea, Tom] Univ Maryland, Med Ctr, R Adams Cowley Shock Trauma Ctr, Baltimore, MD 21201 USA. [Barmparas, Gallinos; Inaba, Kenji] Univ So Calif, Los Angeles Cty Med Ctr, Div Trauma Surg & Surg Crit Care, Los Angeles, CA 90033 USA. [Cancio, Leopoldo C.; Cole, John; Eastridge, Brian; Blackbourne, Lorne] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP DuBose, JJ (reprint author), Univ Maryland, Med Ctr, R Adams Cowley Shock Trauma Ctr, 22 S Greene St,Room T5R46, Baltimore, MD 21201 USA. EM jdubose@umm.edu NR 26 TC 35 Z9 35 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JAN PY 2011 VL 70 IS 1 BP 11 EP 18 DI 10.1097/TA.0b013e318207c563 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 707WD UT WOS:000286320300006 PM 21217475 ER PT J AU Brassell, SA Rice, KR Parker, PM Chen, YM Farrell, JS Cullen, J McLeod, DG AF Brassell, Stephen A. Rice, Kevin R. Parker, Patrick M. Chen, Yongmei Farrell, James S. Cullen, Jennifer McLeod, David G. TI Prostate Cancer in Men 70 Years Old or Older, Indolent or Aggressive: Clinicopathological Analysis and Outcomes SO JOURNAL OF UROLOGY LA English DT Article DE prostatic neoplasms; prostate-specific antigen; early detection of cancer; age factors ID SURVIVAL; THERAPY; AGE AB Purpose: Currently there is a lack of consensus on screening recommendations for prostate cancer with minimal guidance on the cessation of screening in older men. We defined the clinicopathological features and outcomes for men 70 years old or older who were diagnosed with prostate cancer. Materials and Methods: The Center for Prostate Disease Research database was queried for all men diagnosed with prostate cancer from 1989 to 2009. The patients were stratified into age quartiles and by race. Cox proportional hazard models were used to compare clinicopathological features across patient stratifications. Kaplan-Meier analysis was used to compare biochemical recurrence-free, prostate cancer specific and overall survival. Results: Of the 12,081 men evaluated 3,650 (30.2%) were 70 years old or older. These men had a statistically significant higher clinical stage, biopsy grade and prediagnosis prostate specific antigen velocity (p < 0.0001). For those patients who underwent prostatectomy, pathological stage, grade and surgical margin status were all significantly higher in men 70 years old or older. Biochemical recurrence and secondary treatment were also more common in this age group (p < 0.0001). Multivariate analysis revealed age 70 years or older as a significant predictor of biochemical recurrence after prostatectomy (HR 1.45, p = 0.0054). Overall survival was lowest in men age 70 years or older who had surgery, but interestingly the mean time to death was comparable regardless of age. Conclusions: Our findings indicate that as men age, parameters consistent with more aggressive disease become more prevalent. The etiology of this trend is unknown. However, these data may have implications for current screening and treatment recommendations. C1 [Brassell, Stephen A.] Walter Reed Army Med Ctr, Ctr Prostate Dis Res, Urol Serv, Dept Surg, Washington, DC 20307 USA. [Brassell, Stephen A.; Chen, Yongmei; Cullen, Jennifer; McLeod, David G.] Ctr Prostate Dis Res, Bethesda, MD USA. RP Brassell, SA (reprint author), Walter Reed Army Med Ctr, Ctr Prostate Dis Res, Urol Serv, Dept Surg, Ward 56,6900 Georgia Ave NW, Washington, DC 20307 USA. EM Stephen.Brassell@amedd.army.mil NR 17 TC 22 Z9 24 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 J9 J UROLOGY JI J. Urol. PD JAN PY 2011 VL 185 IS 1 BP 132 EP 137 DI 10.1016/j.juro.2010.09.014 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA 692GS UT WOS:000285141900039 PM 21074211 ER PT J AU Sun, YZ Godfrey, DA Godfrey, MA Hong, S Jin, YM Rubin, AM AF Sun, Yizhe Godfrey, Donald A. Godfrey, Matthew A. Hong, Steven Jin, Yong-Ming Rubin, Allan M. TI Changes of amino acid concentrations in the rat vestibular nuclei after midline lesions SO JOURNAL OF VESTIBULAR RESEARCH-EQUILIBRIUM & ORIENTATION LA English DT Article DE GABA; taurine; glycine; glutamate; aspartate ID GAMMA-AMINOBUTYRIC-ACID; CEREBELLAR PEDUNCLE TRANSECTION; PURKINJE-CELL TERMINALS; D-ASPARTATE RECEPTORS; COMMISSURAL NEURONS; COCHLEAR NUCLEUS; GLUTAMATE-DECARBOXYLASE; IMMUNOCYTOCHEMICAL LOCALIZATION; FASTIGIOVESTIBULAR PROJECTIONS; UNILATERAL DEAFFERENTATION AB Changes in concentrations of amino acids, especially GABA, glutamate, and aspartate, occur in vestibular nuclei after removal of cerebellar and labyrinth inputs. Here, we examined the effects of transecting midline-crossing connections between the two vestibular nuclear complexes, which especially include commissural connections. Three rats were euthanized at each of 2, 7, and 30 days after a midline cut at the level of the vestibular nuclei. Two sham-lesioned rats were prepared for surgery but no cut made. Samples of superior (SuVN), dorsal and ventral lateral (LVNd and LVNv), dorsal and ventral medial (MVNd and MVNv), and spinal vestibular nuclei (SpVN) were microdissected from freeze-dried coronal sections and assayed for amino acid concentrations. Reductions of GABA concentration occurred by 2 days and continued through 30 days after surgery in most regions. Glutamate and aspartate concentrations decreased by 2 days in LVN and MVN, then glutamate showed some recovery by 30 days. Glutamine and taurine concentrations increased in almost all regions. Glycine concentration decreased in MVN and LVNv. Our results support association of GABA, glutamate, aspartate, and to some extent glycine, with vestibular crossed connections. Comparisons to our previous studies suggest some complex lesion effects, especially in LVNd. C1 [Godfrey, Donald A.; Godfrey, Matthew A.] Univ Toledo, Dept Surg, Div Otolaryngol & Dent, Coll Med, Toledo, OH 43614 USA. [Sun, Yizhe] Renovo Neural Inc, Cleveland, OH USA. [Hong, Steven] ATTN MCHK DSH, Tripler Army Med Ctr, Tripler, HI USA. [Jin, Yong-Ming] Cleveland Clin, Cerebrovasc Ctr, Cleveland, OH 44106 USA. [Rubin, Allan M.] NW Ohio ENT Consulatants, Sylvania, OH USA. RP Godfrey, DA (reprint author), Univ Toledo, Dept Surg, Div Otolaryngol & Dent, Coll Med, 3065 Arlington Ave, Toledo, OH 43614 USA. EM donald.godfrey@utoledo.edu FU NIH (NIDCD) [DC02550] FX We thank Kelvin Wong and David Zahn for assistance with calculations of data. We thank Dr. William Gunning for allowing us to use his Olympus microscope and Image Pro digital photography system for production of Fig. 1. The study was supported by NIH (NIDCD) grant DC02550. NR 95 TC 1 Z9 1 U1 0 U2 1 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 0957-4271 J9 J VESTIBUL RES-EQUIL JI J. Vestib. Res.-Equilib. Orientat. PY 2011 VL 21 IS 4 BP 175 EP 191 DI 10.3233/VES-2011-0419 PG 17 WC Neurosciences; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 808BM UT WOS:000293948300001 PM 21846951 ER PT J AU Vernati, G Edwards, WH Rocke, TE Little, SF Andrews, GP AF Vernati, G. Edwards, W. H. Rocke, T. E. Little, S. F. Andrews, G. P. TI ANTIGENIC PROFILING OF YERSINIA PESTIS INFECTION IN THE WYOMING COYOTE (CANIS LATRANS) SO JOURNAL OF WILDLIFE DISEASES LA English DT Article DE Coyote; IVIAT; plague; serology; Yersinia pestis ID EXPERIMENTAL PLAGUE INFECTION; OUTER PROTEINS; MICE; CLUSTERS; EFFICACY; DISEASES; GENE; FLIP AB Although Yersinia pestis is classified as a "high-virulence" pathogen, some host species are variably susceptible to disease. Coyotes (Canis latrans) exhibit mild, if any, symptoms during infection, but antibody production occurs postinfection. This immune response has been reported to be against the F1 capsule, although little subsequent characterization has been conducted. To further define the nature of coyote humoral immunity to plague, qualitative serology was conducted to assess the antiplague antibody repertoire. Humoral responses to six plasmid-encoded Y. pestis virulence factors were first examined. Of 20 individual immune coyotes, 90% were reactive to at least one other antigen in the panel other than F1. The frequency of reactivity to low calcium response plasmid (pLcr)-encoded Yersinia protein kinase A (YpkA) and Yersinia outer protein D (YopD) was significantly greater than that previously observed in a murine model for plague. Additionally, both V antigen and plasminogen activator were reactive with over half of the serum samples tested. Reactivity to F1 was markedly less frequent in coyotes (35%). Twenty previously tested antibody-negative samples were also examined. While the majority were negative across the panel, 1.5% were positive for 1-3 non-F1. antigens. In vivo induced antigen technology employed to identify novel chromosomal genes of Y. pestis that are up-regulated during infection resulted in the identification of five proteins, including a flagellar component (FliP) that was uniquely reactive with the coyote serum compared with immune serum from two other host species. Collectively, these data suggest that humoral immunity to pLcr-encoded antigens and the pesticin plasmid (pPst)-encoded Pla antigen may be relevant to plague resistance in coyotes. The serologic profile of Y. pestis chromosomal antigens up-regulated in vivo specific to C. latrans may provide insight into the differences in the pathogen-host responses during Y. pestis infection. C1 [Vernati, G.; Andrews, G. P.] Univ Wyoming, Dept Vet Sci, Laramie, WY 82070 USA. [Edwards, W. H.] Wyoming Game & Fish Dept, Wildlife Dis Lab, Laramie, WY 82070 USA. [Rocke, T. E.] US Geol Survey, Natl Wildlife Hlth Ctr, Madison, WI 53711 USA. [Little, S. F.] USA, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21702 USA. RP Andrews, GP (reprint author), Univ Wyoming, Dept Vet Sci, Laramie, WY 82070 USA. EM gandrews@uwyo.edu OI Rocke, Tonie/0000-0003-3933-1563 NR 24 TC 4 Z9 6 U1 0 U2 5 PU WILDLIFE DISEASE ASSOC, INC PI LAWRENCE PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 USA SN 0090-3558 J9 J WILDLIFE DIS JI J. Wildl. Dis. PD JAN PY 2011 VL 47 IS 1 BP 21 EP 29 PG 9 WC Veterinary Sciences SC Veterinary Sciences GA 720KS UT WOS:000287280200003 PM 21269993 ER PT J AU Gosch, NJC Pope, KL AF Gosch, N. J. C. Pope, K. L. TI Using consumption rate to assess potential predators for biological control of white perch SO KNOWLEDGE AND MANAGEMENT OF AQUATIC ECOSYSTEMS LA English DT Article DE biological control; predation; consumption rate; white perch; Morone americana ID FOOD-WEB MANIPULATION; EUTROPHIC LAKE WIRBEL; FRESH-WATER FISHES; NORTHERN PIKE; YELLOW PERCH; PREY SIZE; WALLEYE; RESERVOIR; BIOMANIPULATION; MORPHOLOGY AB Control of undesirable fishes is important in aquatic systems, and using predation as a tool for biological control is an attractive option to fishery biologists. However, determining the appropriate predators for biological control is critical for success. The objective of this study was to evaluate the utility of consumption rate as an index to determine the most effective predators for biological control of an invasive fish. Consumption rate values were calculated for nine potential predators that prey on white perch Morone americana in Branched Oak and Pawnee reservoirs, Nebraska. The consumption rate index provided a unique and insightful means of determining the potential effectiveness of each predator species in controlling white perch. Cumulative frequency distributions facilitated interpretation by providing a graphical presentation of consumption rates by all individuals within each predator species. Largemouth bass Micropterus salmoides, walleye Sander vitreus and sauger S. canadensis were the most efficient white perch predators in both reservoirs; however, previous attempts to increase biomass of these predators have failed suggesting that successful biological control is unlikely using existing predator species in these Nebraska reservoirs. C1 [Gosch, N. J. C.] Univ Nebraska, Nebraska Cooperat Fish & Wildlife Res Unit, Lincoln, NE 68583 USA. [Gosch, N. J. C.] Univ Nebraska, Sch Nat Resources, Lincoln, NE 68583 USA. [Gosch, N. J. C.] USA Corps Engineers, Kansas City, MO 64106 USA. [Pope, K. L.] Univ Nebraska, US Geol Survey, Nebraska Cooperat Fish & Wildlife Res Unit, Lincoln, NE 68583 USA. [Pope, K. L.] Univ Nebraska, Sch Nat Resources, Lincoln, NE 68583 USA. RP Gosch, NJC (reprint author), Univ Nebraska, Nebraska Cooperat Fish & Wildlife Res Unit, Lincoln, NE 68583 USA. EM Nathan.J.Gosch@usace.army.mil RI Pope, Kevin/D-8096-2011 OI Pope, Kevin/0000-0003-1876-1687 FU U.S. Geological Survey; Nebraska Game and Parks Commission; University of Nebraska; U.S. Fish and Wildlife Service; Wildlife Management Institute FX Special thanks to J. Stittle, L. Pierce, J. Walrath, D. Martin, C. Lewis and T. Barada for field and laboratory assistance. C. Huber, M. Pegg and R. Holland provided valuable comments on an earlier draft of this manuscript. The Nebraska Cooperative Fish and Wildlife Research Unit is jointly supported by a cooperative agreement among the U.S. Geological Survey, the Nebraska Game and Parks Commission, the University of Nebraska, the U.S. Fish and Wildlife Service, and the Wildlife Management Institute. Reference to trade names is for descriptive purposes only and does not imply endorsement by the authors or the U.S. Government. NR 51 TC 3 Z9 3 U1 1 U2 14 PU EDP SCIENCES S A PI LES ULIS CEDEX A PA 17, AVE DU HOGGAR, PA COURTABOEUF, BP 112, F-91944 LES ULIS CEDEX A, FRANCE SN 1961-9502 J9 KNOWL MANAG AQUAT EC JI Knowl. Manag. Aquat. Ecosyst. PY 2011 IS 403 AR 02 DI 10.1051/kmae/2011028 PG 9 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA 879DV UT WOS:000299310800003 ER PT J AU Kim, SB Bae, H Cha, JM Moon, SJ Dokmeci, MR Cropek, DM Khademhosseini, A AF Kim, Sang Bok Bae, Hojae Cha, Jae Min Moon, Sang Jun Dokmeci, Mehmet R. Cropek, Donald M. Khademhosseini, Ali TI A cell-based biosensor for real-time detection of cardiotoxicity using lensfree imaging SO LAB ON A CHIP LA English DT Article ID EMBRYONIC STEM-CELLS; CARDIOMYOCYTES; TOXICITY; CULTURE; DRUGS; ARRAY; CHIP AB A portable and cost-effective real-time cardiotoxicity biosensor was developed using a CMOS imaging module extracted from a commercially available webcam. The detection system consists of a CMOS imaging module, a white LED and a pinhole. Real-time image processing was conducted by comparing reference and live frame images. To evaluate the engineered system, the effects of two different drugs, isoprenaline and doxorubicin, on the beating rate and beat-to-beat variations of ESC-derived cardiomyocytes were measured. The detection system was used to conclude that the beat-to-beat variability increased under treatment with both isoprenaline and doxorubicin. However, the beating rates increased upon the addition of isoprenaline but decreased for cultures supplemented with doxorubicin. Moreover, the response time for both the beating rates and the beat-to-beat variability of ESC-derived cardiomyocytes under treatment of isoprenaline was shorter than for doxorubicin, although the amount of isoprenaline used in the measurement was three orders of magnitude lower than that of doxorubicin. Given its ability to perform real-time cell monitoring in a simple and inexpensive manner, the proposed system may be useful for a range of cell-based biosensing applications. C1 [Kim, Sang Bok; Bae, Hojae; Cha, Jae Min; Moon, Sang Jun; Khademhosseini, Ali] Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Biomed Engn,Dept Med, Boston, MA 02115 USA. [Kim, Sang Bok; Bae, Hojae; Cha, Jae Min; Moon, Sang Jun; Khademhosseini, Ali] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA. [Dokmeci, Mehmet R.] Northeastern Univ, Elect & Comp Engn Dept, Ctr High Rate Nanomfg, Boston, MA 02115 USA. [Cropek, Donald M.] USA, Corps Engineers, Construct Engn Res Lab, Champaign, IL 61822 USA. [Khademhosseini, Ali] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA. RP Khademhosseini, A (reprint author), Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Biomed Engn,Dept Med, Boston, MA 02115 USA. EM alik@rics.bwh.harvard.edu RI Khademhosseini, Ali/A-9435-2010; OI Khademhosseini, Ali/0000-0002-2692-1524; Kim, Sang Bok/0000-0002-6880-2662; Khademhosseini, Ali/0000-0001-6322-8852 FU National Institutes of Health [EB009196, DE019024, EB007249, HL092836]; National Science Foundation [DMR0847287]; Office of Naval Research; Korean Government [NRF-2009-352-D00032] FX This paper was supported by the National Institutes of Health (EB009196; DE019024; EB007249; HL092836), the National Science Foundation CAREER award (DMR0847287) and the Office of Naval Research Young Investigator award. S. B. Kim was partially supported by the National Research Foundation of Korea Grant funded by Korean Government [NRF-2009-352-D00032]. NR 36 TC 44 Z9 45 U1 2 U2 29 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1473-0197 J9 LAB CHIP JI Lab Chip PY 2011 VL 11 IS 10 BP 1801 EP 1807 DI 10.1039/c1lc20098d PG 7 WC Biochemical Research Methods; Chemistry, Multidisciplinary; Nanoscience & Nanotechnology SC Biochemistry & Molecular Biology; Chemistry; Science & Technology - Other Topics GA 755QN UT WOS:000289951200013 PM 21483937 ER PT J AU Carr, R Comer, J Ginsberg, MD Aksimentiev, A AF Carr, Rogan Comer, Jeffrey Ginsberg, Mark D. Aksimentiev, Aleksei TI Atoms-to-microns model for small solute transport through sticky nanochannels SO LAB ON A CHIP LA English DT Article ID MOLECULAR-DYNAMICS SIMULATIONS; BROWNIAN DYNAMICS; HYDROPHILIC SURFACES; SYNTHETIC NANOPORES; DNA TRANSLOCATION; ION CHANNELS; WATER; ADSORPTION; MEMBRANE; PROTEINS AB Modeling the transport of solutes through fluidic systems that have adsorbing surfaces is challenging due to the range of length and time scales involved. The components of such systems typically have dimensions from hundreds of nanometres to microns, whereas adsorption of solutes is sensitive to the atomic-scale structure of the solutes and surfaces. Here, we describe an atomic-resolution Brownian dynamics method for modeling the transport of solutes through sticky nanofluidic channels. Our method can fully recreate the results of all-atom molecular dynamics simulations at a fraction of the computational cost of the latter, which makes simulations of micron-size channels at a millisecond time scale possible without losing information about the atomic-scale features of the system. We demonstrate the capability of our method by simulating the rise and fall of solute concentration in sub-micron-long sticky nanochannels, showing that the atomic-scale features of the channels' surfaces have a dramatic effect on the kinetics of solute transport in and out of the channels. We expect our method to find applications in design and optimization of micro and nanofluidic systems for solute-specific transport and to complement existing approaches to modeling lab-on-a-chip devices by providing atomic scale information at a low computational cost. C1 [Carr, Rogan; Comer, Jeffrey; Aksimentiev, Aleksei] Univ Illinois, Urbana, IL 61801 USA. [Ginsberg, Mark D.] USA, ERDC CERL, Champaign, IL USA. [Aksimentiev, Aleksei] Univ Illinois, Beckman Inst Adv Sci & Technol, Urbana, IL 61801 USA. RP Aksimentiev, A (reprint author), Univ Illinois, 1110 W Green St, Urbana, IL 61801 USA. EM aksiment@illinois.edu RI Comer, Jeffrey/H-4453-2011; OI Aksimentiev, Aleksei/0000-0002-6042-8442 FU National Science Foundation [DMR-0955959]; National Institutes of Health [PHS 5 P41-RR005969]; Petroleum Research Fund [48352-G6]; Army Corps of Engineers Engineer Research and Development Center - Construction Engineering Research Laboratory (ERDC-CERL); TeraGrid [MCA05S028]; Department of Defense at the U.S. Army ERDC, DoD Supercomputing Resource Center, Information Technology Laboratory, Vicksburg, Mississippi FX We would like to thank Ilia Solov'yov for his help with graphics design of the images. This work was supported by a grant from the National Science Foundation (DMR-0955959) and in part by the National Institutes of Health (PHS 5 P41-RR005969) and the Petroleum Research Fund (48352-G6), and through a cooperative research agreement with the Army Corps of Engineers Engineer Research and Development Center - Construction Engineering Research Laboratory (ERDC-CERL). The authors gladly acknowledge supercomputer time provided through TeraGrid Allocation grant MCA05S028 and by the Department of Defense High Performance Computing Modernization Program at the U.S. Army ERDC, DoD Supercomputing Resource Center, Information Technology Laboratory, Vicksburg, Mississippi. NR 65 TC 13 Z9 14 U1 1 U2 9 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1473-0197 J9 LAB CHIP JI Lab Chip PY 2011 VL 11 IS 22 BP 3766 EP 3773 DI 10.1039/c1lc20697d PG 8 WC Biochemical Research Methods; Chemistry, Multidisciplinary; Nanoscience & Nanotechnology SC Biochemistry & Molecular Biology; Chemistry; Science & Technology - Other Topics GA 836GV UT WOS:000296099900003 PM 21986816 ER PT J AU Lesho, E Craft, D Kirkup, BC Waterman, P Summers, A Vahey, MT Kester, KE Bowden, R AF Lesho, Emil Craft, David Kirkup, Benjamin C., Jr. Waterman, Paige Summers, Amy Vahey, Maryanne T. Kester, Kent E. Bowden, Robert TI Surveillance, characterisation, and preservation of multidrug-resistant bacteria SO LANCET INFECTIOUS DISEASES LA English DT Editorial Material ID ACINETOBACTER-BAUMANNII; NOSOCOMIAL INFECTIONS; HEALTH-CARE; HOSPITALS; EFFICACY; IRAQ; NEED C1 [Lesho, Emil; Craft, David; Kirkup, Benjamin C., Jr.; Waterman, Paige; Summers, Amy; Bowden, Robert] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20902 USA. RP Lesho, E (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20902 USA. EM carolinelesho@yahoo.com RI Kirkup, Benjamin/C-3610-2009 OI Kirkup, Benjamin/0000-0002-8722-6218 NR 15 TC 8 Z9 8 U1 1 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1473-3099 J9 LANCET INFECT DIS JI Lancet Infect. Dis. PD JAN PY 2011 VL 11 IS 1 BP 8 EP 10 DI 10.1016/S1473-3099(10)70261-9 PG 3 WC Infectious Diseases SC Infectious Diseases GA 719CR UT WOS:000287177700006 PM 21183141 ER PT S AU Field, LA Deyarmin, B Shriver, CD Ellsworth, DL Ellsworth, RE AF Field, Lori A. Deyarmin, Brenda Shriver, Craig D. Ellsworth, Darrell L. Ellsworth, Rachel E. BE Murray, GI TI Laser Microdissection for Gene Expression Profiling SO LASER CAPTURE MICRODISSECTION: METHODS AND PROTOCOLS, SECOND EDITION SE Methods in Molecular Biology LA English DT Article; Book Chapter DE Laser microdissection; Gene expression; Microarray; Frozen tissue; FFPE; Molecular signature; Breast cancer ID BREAST-TUMORS; CANCER; METASTASES; PATTERNS; DISEASE AB Microarray-based gene expression profiling is revolutionizing biomedical research by allowing expression profiles of thousands of genes to be interrogated in a single experiment. In cancer research, the use of laser microdissection (LM) to isolate RNA from tissues provides the ability to accurately identify molecular profiles from different cell types that comprise the tumor and its surrounding microenvironment. Because RNA is an unstable molecule, the quality of RNA extracted from tissues can be affected by sample preparation and processing. Thus, special protocols have been developed to isolate research-quality RNA after LM. This chapter provides detailed descriptions of protocols used to generate microarray data from high-quality frozen breast tissue specimens, as well as challenges associated with formalin-fixed paraffin-embedded specimens. C1 [Field, Lori A.; Ellsworth, Rachel E.] Windber Res Inst, Clin Breast Care Project, Windber, PA USA. [Shriver, Craig D.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Field, LA (reprint author), Windber Res Inst, Clin Breast Care Project, Windber, PA USA. NR 8 TC 4 Z9 4 U1 0 U2 2 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA SN 1064-3745 BN 978-1-61779-162-8 J9 METHODS MOL BIOL JI Methods Mol. Biol. PY 2011 VL 755 BP 17 EP 45 DI 10.1007/978-1-61779-163-5_2 D2 10.1007/978-1-61779-163-5 PG 29 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Pathology SC Biochemistry & Molecular Biology; Pathology GA BWE67 UT WOS:000293771800002 PM 21761291 ER PT S AU Newburgh, GA Dubinskii, M AF Newburgh, G. A. Dubinskii, Mark BE Dubinskii, M Post, SG TI Resonantly diode pumped Ho3+:YVO4 2.05-mu m laser SO LASER TECHNOLOGY FOR DEFENSE AND SECURITY VII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on the Laser Technology for Defense and Security VII CY APR 25-27, 2011 CL Orlando, FL SP SPIE ID MU-M AB We report what is believed to be the first laser operation based on Ho3+-doped YVO4. The Ho+3:YVO4 was resonantly diode-pumped at similar to 1.93 mu m to produce up to 1.6 W of continuous wave (CW) output power at similar to 2.054 mu m. The laser had a slope efficiency of similar to 38% with respect to absorbed power. We have measured the absorption and stimulated emission cross sections of The Ho+3:YVO4 at 77 K and present the calculated gain cross section spectrum at 77 K for different excited state inversion levels. C1 [Newburgh, G. A.; Dubinskii, Mark] USA, Res Lab, Adelphi, MD 20783 USA. RP Newburgh, GA (reprint author), USA, Res Lab, RDRL SEE O 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM gnewburgh@arl.army.mil NR 7 TC 10 Z9 10 U1 1 U2 6 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-613-4 J9 PROC SPIE PY 2011 VL 8039 AR 803905 DI 10.1117/12.886571 PG 6 WC Materials Science, Multidisciplinary; Optics; Physics, Applied SC Materials Science; Optics; Physics GA BVO30 UT WOS:000292040500004 ER PT B AU Bernardinez, M Buradha, K Cochie, KS Saenz, J Furterer, SL AF Bernardinez, Marcela Buradha, Khalid Cochie, Kevin S. Saenz, Jose Furterer, Sandra L. BE Cudney, EA Furterer, SL Dietrich, DM TI Sunshine High School Discipline Process Improvement: A Lean Six Sigma Case Study SO LEAN SYSTEMS: APPLICATIONS AND CASE STUDIES IN MANUFACTURING, SERVICE,AND HEALTHCARE LA English DT Article; Book Chapter C1 [Bernardinez, Marcela; Buradha, Khalid] Univ Cent Florida, Ind Engn & Management Syst, Orlando, FL 32816 USA. [Cochie, Kevin S.] US Army, Washington, DC 20310 USA. [Saenz, Jose] Dell Inc, CRM Program, Arraijan, Panama. [Furterer, Sandra L.] Southern Polytech State Univ, Dept Ind Engn Technol, New Albany, OH USA. RP Bernardinez, M (reprint author), Univ Cent Florida, Ind Engn & Management Syst, Orlando, FL 32816 USA. NR 2 TC 0 Z9 0 U1 0 U2 1 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-5681-2; 978-1-4665-5680-5 PY 2011 BP 313 EP 374 PG 62 WC Operations Research & Management Science SC Operations Research & Management Science GA BD7SX UT WOS:000363531700019 ER PT S AU Sano, T Yu, J Davis, B DeLorme, R Cho, K AF Sano, Tomoko Yu, Jian Davis, Bruce DeLorme, Richard Cho, Kyu BE Sillekens, WH Agnew, SR Neelameggham, NR Mathaudhu, SN TI IN-SITU SCANNING ELECTRON MICROSCOPY COMPARISON OF MICROSTRUCTURE AND DEFORMATION BETWEEN WE43-F AND WE43-T5 MAGNESIUM ALLOYS SO MAGNESIUM TECHNOLOGY 2011 SE Magnesium Technology Series LA English DT Proceedings Paper CT Conference on Magnesium Technology held during TMS 140th Annual Meeting and Exhibition CY FEB 27-MAR 03, 2011 CL San Diego, CA SP The Minerals, Met & Mat Soc, The Minerals, Met & Mat Soc, Light Met Div, Magnesium Comm DE In-situ; magnesium; microstructure; deformation ID MECHANICAL-PROPERTIES; MG ALLOY; PRECIPITATION; BEHAVIOR; CREEP AB In-situ tensile testing in the scanning electron microscope was used to investigate the quasi-static deformation behavior and fracture mechanism of WE43 magnesium alloys. The in-situ tensile experiments were conducted at room temperature at a constant crosshead speed of 0.5 mm / min. One set of samples was a rolled and quenched F temper alloy and the other set was an artificially aged T5 temper alloy. The objective of this research was to determine the effect of tempering on precipitates chemistries, microstructure, and mechanical properties. The sample orientation is known to affect the tensile properties. Hence tensile specimens with different sample orientation were tested. The crystallographic orientations were characterized by electron backscattered diffraction. Strong textures were observed with rolling plane crystals indicating a basal plane orientation. C1 [Sano, Tomoko; Yu, Jian; Cho, Kyu] US Army, Res Lab, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA. RP Sano, T (reprint author), US Army, Res Lab, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA. NR 14 TC 1 Z9 1 U1 1 U2 2 PU JOHN WILEY & SONS PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER, W SUSSEX PO 19 8SQ, ENGLAND SN 1545-4150 BN 978-1-11802-936-7 J9 MAGNESIUM TECHNOLOGY PY 2011 BP 345 EP 348 PG 4 WC Metallurgy & Metallurgical Engineering SC Metallurgy & Metallurgical Engineering GA BHC57 UT WOS:000324984000064 ER PT S AU Jones, TL Kondoh, K AF Jones, Tyrone L. Kondoh, Katsuyoshi BE Sillekens, WH Agnew, SR Neelameggham, NR Mathaudhu, SN TI BALLISTIC ANALYSIS OF NEW MILITARY GRADE MAGNESIUM ALLOYS FOR ARMOR APPLICATIONS SO MAGNESIUM TECHNOLOGY 2011 SE Magnesium Technology Series LA English DT Proceedings Paper CT Conference on Magnesium Technology held during TMS 140th Annual Meeting and Exhibition CY FEB 27-MAR 03, 2011 CL San Diego, CA SP The Minerals, Met & Mat Soc, The Minerals, Met & Mat Soc, Light Met Div, Magnesium Comm DE Magnesium Alloys; Ballistic Performance; Armor; Rapid Solidification Process; Spinning Water Atomization Process (SWAP) ID TEMPERATURE; CAST AB Since 2006, the U. S. Army has been evaluating magnesium (Mg) alloys for ballistic structural applications. While Mg-alloys have been used in military structural applications since WWII, very little research has been done to improve its mediocre ballistic performance. The Army's need for ultra-lightweight armor systems has led to research and development of high strength, high ductility Mg-alloys. The U. S. Army Research Laboratory contracted through International Technology Center-Pacific Contract Number FA-5209-09-P-0158 with the Joining and Welding Research Instituteof Osaka University to develop the next generation of high strength, high ductility Mg-alloys using a novel Spinning Water Atomization Process for rapid solidification. New alloys AMX602 and ZAXE1711 in extruded bar form were characterized for microstructure, mechanical, and ballistic response. Significant increases in ballistic performance were evident when compared to the baseline alloy AZ31B. C1 [Jones, Tyrone L.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Kondoh, Katsuyoshi] Osaka Univ, JWRI, Osaka 5670047, Japan. RP Jones, TL (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 15 TC 0 Z9 0 U1 1 U2 6 PU JOHN WILEY & SONS PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER, W SUSSEX PO 19 8SQ, ENGLAND SN 1545-4150 BN 978-1-11802-936-7 J9 MAGNESIUM TECHNOLOGY PY 2011 BP 425 EP 430 PG 6 WC Metallurgy & Metallurgical Engineering SC Metallurgy & Metallurgical Engineering GA BHC57 UT WOS:000324984000080 ER PT S AU Mathaudhu, S Kecskes, L Darling, K AF Mathaudhu, Suveen Kecskes, Laszlo Darling, Kristopher BE Sillekens, WH Agnew, SR Neelameggham, NR Mathaudhu, SN TI THERMALLY-STABILIZED NANOCRYSTALLINE MAGNESIUM ALLOYS SO MAGNESIUM TECHNOLOGY 2011 SE Magnesium Technology Series LA English DT Proceedings Paper CT Conference on Magnesium Technology held during TMS 140th Annual Meeting and Exhibition CY FEB 27-MAR 03, 2011 CL San Diego, CA SP The Minerals, Met & Mat Soc, The Minerals, Met & Mat Soc, Light Met Div, Magnesium Comm DE Magnesium; Nanocrystalline; Strength; Thermal Stability ID AUTOMOTIVE INDUSTRY AB Advanced nanocrystalline alloys have shown remarkable property improvements, particularly, order-of-magnitude strength increases, when compared to their coarse-grained counterparts. However, a major obstruction to the widespread application of such materials is the degradation of properties via rapid grain growth at even ambient temperatures. Conventional methods for circumvention of this problem at low temperatures have largely steered toward kinetically pinning the boundaries with disperoids, or through misorientation of grain boundaries, yet even these methods have limited utility at elevated temperatures needed for routine sintering and forming operations. In this work, we will present a synergistic approach to the development of thermally stable nanostructured Mg-alloys which incorporates elements of predictive modeling of suitable alloy systems, fabrication of nanostructured alloy powders by high energy ball milling and consolidation of the powders at elevated temperatures. C1 [Mathaudhu, Suveen] US Army, Res Off, Div Mat Sci, POB 12211, Res Triangle Pk, NC 27709 USA. [Kecskes, Laszlo; Darling, Kristopher] US Army, Res Lab, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA. RP Mathaudhu, S (reprint author), US Army, Res Off, Div Mat Sci, POB 12211, Res Triangle Pk, NC 27709 USA. RI Kecskes, Laszlo/F-6880-2014; Mathaudhu, Suveen/B-4192-2009 OI Kecskes, Laszlo/0000-0002-1342-3729; NR 11 TC 2 Z9 2 U1 0 U2 3 PU JOHN WILEY & SONS PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER, W SUSSEX PO 19 8SQ, ENGLAND SN 1545-4150 BN 978-1-11802-936-7 J9 MAGNESIUM TECHNOLOGY PY 2011 BP 453 EP 456 PG 4 WC Metallurgy & Metallurgical Engineering SC Metallurgy & Metallurgical Engineering GA BHC57 UT WOS:000324984000085 ER PT J AU Hayes, MC Rubin, SP Reisenbichler, RR Goetz, FA Jeanes, E McBride, A AF Hayes, Michael C. Rubin, Stephen P. Reisenbichler, Reginald R. Goetz, Fred A. Jeanes, Eric McBride, Aundrea TI Marine Habitat Use by Anadromous Bull Trout from the Skagit River, Washington SO MARINE AND COASTAL FISHERIES LA English DT Article ID HOME-RANGE SIZE; VARDEN SALVELINUS-MALMA; DOLLY-VARDEN; ARCTIC CHARR; SEA-TROUT; FOOD AVAILABILITY; SALMO-TRUTTA; BROOK CHARR; MIGRATION; MONTANA AB Acoustic telemetry was used to describe fish positions and marine habitat use by tagged bull trout Salvelinus confluentus from the Skagit River, Washington. In March and April 2006, 20 fish were captured and tagged in the lower Skagit River, while 15 fish from the Swinomish Channel were tagged during May and June. Sixteen fish tagged in 2004 and 2005 were also detected during the study. Fish entered Skagit Bay from March to May and returned to the river from May to August. The saltwater residency for the 13 fish detected during the out-migration and return migration ranged from 36 to 133 d (mean +/- SD, 75 +/- 22 d). Most bull trout were detected less than 14 km (8.5 +/- 4.4 km) from the Skagit River, and several bay residents used the Swinomish Channel while migrating. The bull trout detected in the bay were associated with the shoreline (distance from shore, 0.32 +/- 0.27 km) and occupied shallow-water habitats (mean water column depth, <4.0 m). The modified-minimum convex polygons (MMCPs) used to describe the habitats used by 14 bay fish showed that most areas were less than 1,000 ha. The mean length of the shoreline bordering the MMCPs was 2.8 km (range, 0.01-5.7 km) for bay fish and 0.6 km for 2 channel residents. Coastal deposits, low banks, and sediment bluffs were common shoreline classes found within the MMCPs of bay fish, while modified shoreline classes usually included concrete bulkheads and riprap. Mixed fines, mixed coarse sediments, and sand were common substrate classes found within MMCPs; green algae and eelgrass (Zostera sp.) vegetation classes made up more than 70% of the area used by bull trout. Our results will help managers identify specific nearshore areas that may require further protection to sustain the unique anadromous life history of bull trout. C1 [Hayes, Michael C.; Rubin, Stephen P.; Reisenbichler, Reginald R.] US Geol Survey, Western Fisheries Res Ctr, Seattle, WA 98115 USA. [Goetz, Fred A.] USA, Corps Engineers, Environm Resources Sect, Seattle, WA 98124 USA. [Jeanes, Eric] R2 Resource Consultants Inc, Redmond, WA 98052 USA. [McBride, Aundrea] Skagit River Syst Cooperat, La Conner, WA 98257 USA. RP Hayes, MC (reprint author), US Geol Survey, Western Fisheries Res Ctr, 6505 NE 65th St, Seattle, WA 98115 USA. EM mhayes@usgs.gov OI HAYES, MICHAEL/0000-0002-9060-0565 FU U.S. Geological Survey Coastal Habitats in Puget Sound (CHIPS) FX We would like to especially acknowledge the efforts of our Student Conservation Association interns, Tiffany Anders and Rae Mooney, who happily spent many long days in difficult conditions locating bull trout in Skagit Bay. We also recognize the efforts of Curt Kraemer, who helped to capture and tag many of the fish used in this study. Thanks also to Skagit River System Cooperative personnel, including Karen Wolf who assisted with GIS mapping and Rich Henderson and his staff who captured many of the fish studied. Debbie Reusser and Rachel Nehmer provided superior expertise and training in GIS mapping, Mary Moser (National Oceanic and Atmospheric Administration) loaned us telemetry equipment, and Mike Parsley (U.S. Geological Survey) assisted in planning use of a survey boat and provided much of the telemetry equipment. Finally, a special thanks to Rob Jackson for assistance in boat and trailer maintenance. This project was partially funded by the U.S. Geological Survey Coastal Habitats in Puget Sound (CHIPS) project. Reference to trade names does not imply endorsement by the U.S. Government. NR 61 TC 8 Z9 8 U1 2 U2 26 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1942-5120 J9 MAR COAST FISH JI Mar. Coast. Fish. PY 2011 VL 3 IS 1 BP 394 EP 410 DI 10.1080/19425120.2011.640893 PG 17 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA 873IJ UT WOS:000298874700030 ER PT J AU Turner, B AF Turner, Brian TI Horses SO MASSACHUSETTS REVIEW LA English DT Poetry C1 [Turner, Brian] USA, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU UNIV MASSACHUSETTS MASSACHUSETTS REVIEW PI AMHERST PA MEMORIAL HALL, AMHERST, MA 01003 USA SN 0025-4878 J9 MASS REV JI Mass. Rev. PY 2011 VL 52 IS 3-4 SI SI BP 391 EP 392 PG 2 WC Literary Reviews SC Literature GA 854HE UT WOS:000297484800005 ER PT J AU Scranton, R AF Scranton, Roy TI Copley Square Blues SO MASSACHUSETTS REVIEW LA English DT Poetry C1 [Scranton, Roy] USA, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU UNIV MASSACHUSETTS MASSACHUSETTS REVIEW PI AMHERST PA MEMORIAL HALL, AMHERST, MA 01003 USA SN 0025-4878 J9 MASS REV JI Mass. Rev. PY 2011 VL 52 IS 3-4 SI SI BP 744 EP 745 PG 2 WC Literary Reviews SC Literature GA 854HE UT WOS:000297484800053 ER PT J AU Kecskes, L Butler, B Oniashvili, G Aslamazishvili, Z Zakharov, G Peikrishvili, A AF Kecskes, Laszlo Butler, Brady Oniashvili, George Aslamazishvili, Zurab Zakharov, Garegin Peikrishvili, Akaki TI Effect of Titanium-Aluminum Ratio on the Thermal Explosion Processing of TiAl-TiB0.6 Layered Composites SO MATERIALS AND MANUFACTURING PROCESSES LA English DT Article DE Aluminum; Boron; Combustion synthesis; Reaction mechanism; SHS; Titanium; Thermal explosion ID COMBUSTION SYNTHESIS; SLIDING WEAR AB Bi- and trilayer composites of titanium aluminides (Ti-Al) and substoichiometric titanium boride (TiB0.6) have been fabricated from green compacts placed under pressure. Ti-Al blends with ratios of 3:1, 1:1, or 1:3 have been prepared by ball milling. Subsequent to the preparation of the precursor blends, plate-shaped green compacts of Ti-Al and Ti-B-0.6 were pressed at room temperature. Green compacts were stacked in a layered geometry and were heated rapidly under a static pressure of about 10 bar. After the temperature reached 1300-1400 degrees C, the Ti-Al and TiB0.6 phases were synthesized by the conversion of the reactants into the product phases (also known as "thermal explosion" processing) and simultaneously consolidated and joined under a pressure of 80-100 bar. Scanning electron microscopy (SEM) examination showed that the Ti-Al layer was highly heterogeneous, and the extent of heterogeneity depended strongly on the respective elemental ratio of Ti to Al. Furthermore, the conversion from reactants to products was found to be determined by the overall heat available during the thermal explosion processing step. Unlike the Ti-Al, the TiB0.6 layer was more uniform; however, the combination of heat and pressure was found to be insufficient to fully densify the aluminide layer. These and other features of the layered intermetallic structures will be discussed. C1 [Kecskes, Laszlo; Butler, Brady] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Oniashvili, George; Aslamazishvili, Zurab; Zakharov, Garegin] Tavadze Inst Met & Mat Sci, Tbilisi, Rep of Georgia. [Peikrishvili, Akaki] Tsulukidze Inst Min Technol, Tbilisi, Rep of Georgia. RP Kecskes, L (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM kecskes@arl.army.mil RI Kecskes, Laszlo/F-6880-2014 OI Kecskes, Laszlo/0000-0002-1342-3729 NR 17 TC 2 Z9 2 U1 0 U2 4 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1042-6914 EI 1532-2475 J9 MATER MANUF PROCESS JI Mater. Manuf. Process. PY 2011 VL 26 IS 9 BP 1157 EP 1163 DI 10.1080/10426914.2010.536930 PG 7 WC Engineering, Manufacturing; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 882PU UT WOS:000299577200009 ER PT J AU Wei, QM Kecskes, LJ AF Wei, Qiuming Kecskes, Laszlo J. BE Li, JCM TI DYNAMIC MECHANICAL BEHAVIOR OF ULTRAFINE AND NANOCRYSTALLINE REFRACTORY METALS SO MECHANICAL PROPERTIES OF NANOCRYSTALLINE MATERIALS LA English DT Article; Book Chapter ID SEVERE PLASTIC-DEFORMATION; BULK NANOSTRUCTURED MATERIALS; ADIABATIC SHEAR LOCALIZATION; STRAIN-RATE SENSITIVITY; TUNGSTEN HEAVY ALLOYS; HIGH-PRESSURE TORSION; POLYCRYSTALLINE TUNGSTEN; TENSILE DEFORMATION; STAINLESS-STEEL; FLOW-STRESS C1 [Wei, Qiuming] Univ N Carolina, Dept Mech Engn & Engn Sci, Charlotte, NC 28223 USA. [Kecskes, Laszlo J.] USA, Weap & Mat Res Directorate, AMSRD ARL WM MB, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Wei, QM (reprint author), Univ N Carolina, Dept Mech Engn & Engn Sci, 9201 Univ City Blvd, Charlotte, NC 28223 USA. EM qwei@uncc.edu; kecskes@arl.army.mil RI Wei, Qiuming/B-7579-2008; Kecskes, Laszlo/F-6880-2014 OI Kecskes, Laszlo/0000-0002-1342-3729 NR 76 TC 3 Z9 3 U1 0 U2 4 PU PAN STANFORD PUBLISHING PTE LTD PI SINGAPORE PA PENTHOUSE LEVEL, SUNTEC TOWER 3, 8 TEMASEK BLVD, SINGAPORE, 038988, SINGAPORE BN 978-9-81424-175-5 PY 2011 BP 213 EP 243 D2 10.4032/9789814241755 PG 31 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Mechanics SC Science & Technology - Other Topics; Materials Science; Mechanics GA BXV58 UT WOS:000297273100010 ER PT J AU Albersen, M Mwamukonda, KB Shindel, AW Lue, TF AF Albersen, Maarten Mwamukonda, Kuwong B. Shindel, Alan W. Lue, Tom F. TI Evaluation and Treatment of Erectile Dysfunction SO MEDICAL CLINICS OF NORTH AMERICA LA English DT Article DE Erectile dysfunction; Phosphodiesterase 5 inhibitors; Apomorphine SL; Intracavernous injection; Prostaglandin; Evaluation; Assessment; Treatment ID PHOSPHODIESTERASE TYPE-5 INHIBITORS; INTERNATIONAL INDEX; SEXUAL DYSFUNCTION; CONTROLLED-TRIAL; 2009 UPDATE; THERAPY; LIFE; PHARMACOTHERAPY; SILDENAFIL; TADALAFIL AB Erectile dysfunction (ED) is a prevalent and important disease that has been associated with various comorbidities. The evaluation of patients with ED should include a general health assessment followed by a discussion of reversible factors and lifestyle changes that might help preserve erectile capacity. Numerous effective treatment options are currently available. A frank discussion about use and side effects of these therapies is required to optimize success. Although oral pharmacologic treatments can be initiated and monitored by the primary care physician, patients who do not experience response to these treatments may be best served by referral to a sexual medicine specialist for further assessment and consideration of other treatment options. This article discusses the physiology and pathophysiology of erectile function in men, how the primary care physician may address the clinical problem of ED in practice, and when specialty referral is indicated. C1 [Lue, Tom F.] Univ Calif San Francisco, Dept Urol, San Francisco, CA 94143 USA. [Albersen, Maarten] Katholieke Univ Leuven Hosp, Dept Urol, Lab Expt Urol, B-3000 Leuven, Belgium. [Mwamukonda, Kuwong B.] Brooke Army Med Ctr, SAUSHEC Urol Program, Houston, TX 78234 USA. [Shindel, Alan W.] Univ Calif Davis, Dept Urol, Lawrence J Ellison Ambulatory Care Ctr, Sacramento, CA 95817 USA. RP Lue, TF (reprint author), Univ Calif San Francisco, Dept Urol, 400 Parnassus Ave,Campus Box 0738, San Francisco, CA 94143 USA. EM Tlue@urology.ucsf.edu FU Bayer Healthcare Belgium; American Medical Systems FX Dr Maarten Albersen has received an unrestricted educational grant from Bayer Healthcare Belgium and is a scholar of the European Society for Surgical Oncology, Belgische Vereniging voor Urologie, and the Federico Foundation.; Dr Alan W. Shindel has received a research grant from American Medical Systems, and is an informal consultant for Boehringer Ingelheim. NR 34 TC 10 Z9 11 U1 1 U2 5 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0025-7125 J9 MED CLIN N AM JI Med. Clin. N. Am. PD JAN PY 2011 VL 95 IS 1 BP 201 EP + DI 10.1016/j.mcna.2010.08.016 PG 13 WC Medicine, General & Internal SC General & Internal Medicine GA 697BA UT WOS:000285486400018 PM 21095423 ER PT S AU Walker, MI Walker, RB Morgan, JS Bernhagen, M Markin, N Boedeker, B AF Walker, Madison I. Walker, Robert B. Morgan, Jeffrey S. Bernhagen, Mary Markin, Nicholas Boedeker, Ben H. BE Westwood, JD Westwood, SW FellanderTsai, L Haluck, RS Hoffman, HM Robb, RA Senger, S Vosburgh, KG TI The Use of Virtual Training to Support Insertion of Advanced Technology at Remote Military Locations SO MEDICINE MEETS VIRTUAL REALITY 18 SE Studies in Health Technology and Informatics LA English DT Proceedings Paper CT 18th Medicine Meets Virtual Reality Conference / NextMed Conference CY FEB, 2011 CL Newport Beach, CA DE Intubation training; videolaryngoscopy; video conferencing ID ENDOTRACHEAL INTUBATION AB Effective training in advanced medical technologies is essential for military healthcare providers to support the far forward battlefield. The use of modern video communication technologies and novel medical devices can be utilized for meeting this challenge. This study demonstrates the combined use of video conferencing equipment and videolaryngoscopy in the virtual training of a novice in videolaryngoscopy, nasal intubation and airway foreign body removal. C1 [Walker, Madison I.; Walker, Robert B.; Morgan, Jeffrey S.] US Army, European Reg Med Command, Heidelberg, Germany. [Bernhagen, Mary; Markin, Nicholas; Boedeker, Ben H.] Univ Nebraska Med Ctr, Dept Anesthesiol, 984455 Nebraska Med Ctr, Omaha, NE 68198 USA. RP Boedeker, B (reprint author), Univ Nebraska Med Ctr, Dept Anesthesiol, 984455 Nebraska Med Ctr, Omaha, NE 68198 USA. EM bboedeker@unmc.edu NR 4 TC 2 Z9 2 U1 0 U2 0 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 0926-9630 BN 978-1-60750-706-2 J9 STUD HEALTH TECHNOL PY 2011 VL 163 BP 688 EP 690 DI 10.3233/978-1-60750-706-2-688 PG 3 WC Computer Science, Interdisciplinary Applications; Health Care Sciences & Services; Medical Informatics SC Computer Science; Health Care Sciences & Services; Medical Informatics GA BG8CY UT WOS:000392219500134 PM 21335881 ER PT B AU Phinney, S Crane, NJ Gage, FA Gorbach, AM Elster, EA AF Phinney, Samuel Crane, Nicole J. Gage, Frederick A. Gorbach, Alexander M. Elster, Eric A. BE Uygun, K Lee, CY TI Use of Optical Imaging and Spectroscopy in Assessment of Organ Perfusion SO METHODS IN BIOENGINEERING: ORGAN PRESERVATION AND REENGINEERING SE Artech House Methods in Bioengineering Series LA English DT Article; Book Chapter DE imaging; infrared imaging (IR); organ perfusion; three-charged coupled device (3-CCD); visible reflectance imaging system (VRIS); ischemia/reperfusion injury; renal transplantation; pump perfusion ID VISIBLE-LIGHT SPECTROSCOPY; IN-VIVO; OXYGEN-SATURATION; INTRAOPERATIVE ASSESSMENT; DIFFUSE-REFLECTANCE; PULSATILE PERFUSION; TISSUE PERFUSION; RENAL-ALLOGRAFTS; NITRIC-OXIDE; BLOOD-FLOW AB We present procedures to use imaging to assess organ perfusion in an ischemia/reperfusion injury model in the intraoperative and organ procurement setting, in particular, on pump perfusion. These technologies, namely 3-CCD, IR, and VRIS imaging, use the spectral signatures of kidneys to determine tissue oxygenation and perfusion. This information not only correlates directly with the physiology of organ perfusion but can be provided in a clinically useful, real-time format. Utilization of the technologies in tandem for quantitative assessment of organ viability is discussed. C1 [Crane, Nicole J.; Gage, Frederick A.; Elster, Eric A.] USN, Dept Regenerat Med, Operat & Undersea Med Directorate, Med Res Ctr, Silver Spring, MD 20910 USA. [Phinney, Samuel] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Gorbach, Alexander M.] Natl Inst Biomed Imaging & Bioengn, NIH, Bethesda, MD USA. [Elster, Eric A.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. RP Elster, EA (reprint author), USN, Dept Regenerat Med, Operat & Undersea Med Directorate, Med Res Ctr, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM eric.elster1@med.navy.mil NR 27 TC 0 Z9 0 U1 0 U2 2 PU ARTECH HOUSE PI NORWOOD PA 685 CANTON ST, NORWOOD, MA 02062 USA BN 978-1-60807-013-8 J9 ARTECH HSE METH BIOE JI Art. Hse. Meth. Bioengr. Ser. PY 2011 BP 137 EP 159 PG 23 WC Cell & Tissue Engineering; Engineering, Biomedical; Transplantation SC Cell Biology; Engineering; Transplantation GA BVN87 UT WOS:000292008900008 ER PT B AU Skowronski, E Lipkin, WI AF Skowronski, Evan Lipkin, W. Ian BE Budowle, B Schutzer, SE Breeze, RG Keim, PS Morse, SA TI Molecular Microbial Surveillance and Discovery in Bioforensics SO MICROBIAL FORENSICS, 2ND EDITION LA English DT Article; Book Chapter ID POLYMERASE-CHAIN-REACTION; REAL-TIME PCR; REVERSE TRANSCRIPTION-PCR; MULTIPLEX PCR; UNITED-STATES; INHALATIONAL ANTHRAX; BACILLUS-ANTHRACIS; RESPIRATORY PATHOGENS; RAPID IDENTIFICATION; MASS-SPECTROMETRY C1 [Skowronski, Evan] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. [Lipkin, W. Ian] Columbia Univ, Ctr Infect & Immun, Mailman Sch Publ Hlth, New York, NY USA. [Lipkin, W. Ian] Columbia Univ, Coll Phys & Surg, New York, NY USA. RP Skowronski, E (reprint author), US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. NR 70 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER ACADEMIC PRESS INC PI SAN DIEGO PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA BN 978-0-12-382007-5; 978-0-12-382006-8 PY 2011 BP 173 EP 185 DI 10.1016/B978-0-12-382006-8.00011-6 PG 13 WC Biotechnology & Applied Microbiology; Medicine, Legal SC Biotechnology & Applied Microbiology; Legal Medicine GA BIE39 UT WOS:000327881100013 ER PT J AU Yao, B Heinrich, H Smith, C van den Bergh, M Cho, K Sohn, YH AF Yao, Bo Heinrich, Helge Smith, Cory van den Bergh, Mark Cho, Kyu Sohn, Yong-ho TI Hollow-cone dark-field transmission electron microscopy for dislocation density characterization of trimodal Al composites SO MICRON LA English DT Review DE Transmission electron microscopy; Dislocation density; Nanocrystalline; Hollow-cone dark-field; Two beam condition ID STRENGTH; DUCTILITY; MATRIX; METAL AB This paper describes a methodology based on hollow-cone dark-field (HCDF) transmission electron microscopy (TEM) to study dislocation structures in both nano- and micro-crystalline grains Although the conventional approach based on a two-beam condition has been commonly used to acquire weak-beam dark-field (WBDF) TEM images for dislocation structure characterization it is very challenging to employ this technique to study nanocrystalltne materials especially when the grams are less than 100 nm in diameter Compared to the conventional two-beam approach the method described in this paper is more conducive for obtaining high-quality WBDF-TEM images Furthermore the method is suitable for studying samples with both nanocrystalline and coarse-grains A trimodal Al metal-matrix-composite (MMC) consisting of B(4)C particles a nanocrystalline Al (NC-Al) phase and a coarse-grained Al (CG-Al) phase has been reported to exhibit an extremely high strength and tailorable ductility The dislocations in both NC-Al and CG-Al phases of the trimodal Al MMCs at different fabrication stages were examined using the HCDF method described The influence of the dislocation density in both NC-Al and CG-Al phases on the strength and ductility of the composite is also discussed (C) 2010 Elsevier Ltd All rights reserved C1 [Yao, Bo; Sohn, Yong-ho] Univ Cent Florida, Dept Mech Mat & Aerosp Engn, Adv Mat Proc & Anal Ctr, Orlando, FL 32816 USA. [Heinrich, Helge] Univ Cent Florida, Dept Phys, Adv Mat Proc & Anal Ctr, Orlando, FL 32816 USA. [Smith, Cory; van den Bergh, Mark] DWA Aluminum Composites, Chatsworth, CA 91311 USA. [Cho, Kyu] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Yao, B (reprint author), Univ Cent Florida, Dept Mech Mat & Aerosp Engn, Adv Mat Proc & Anal Ctr, Orlando, FL 32816 USA. RI Sohn, Yongho/A-8517-2010; Yao, Bo/C-9927-2011 OI Sohn, Yongho/0000-0003-3723-4743; FU U S Army Research Laboratory (ARL) [W911NF-07-2-0073] FX The Materials Characterization Facility (MCF) at the University of Central Florida (UCF) and assistance from engineers at MCF are gratefully acknowledged Research was sponsored by U S Army Research Laboratory (ARL) and was accomplished under Cooperative Agreement W911NF-07-2-0073 The views and conclusions made in this document are those of the authors and should not be interpreted as representing the official policies either expressed or implied of ARL or the US Government The US Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon NR 19 TC 3 Z9 3 U1 0 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0968-4328 J9 MICRON JI Micron PD JAN PY 2011 VL 42 IS 1 BP 29 EP 35 DI 10.1016/j.micron.2010.08.010 PG 7 WC Microscopy SC Microscopy GA 686DP UT WOS:000284677300005 PM 20869257 ER PT J AU Lesho, EP Jawad, NK Hameed, HM AF Lesho, Emil P. Jawad, Naseer K. Hameed, Husam M. TI Towards a Better Approach to Medical Humanitarian Assistance in Iraq and Future Counterinsurgency Operations SO MILITARY MEDICINE LA English DT Editorial Material C1 [Lesho, Emil P.] 3rd Infantry Div, Brigade Combat Team 2, Savannah, GA USA. [Lesho, Emil P.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Jawad, Naseer K.; Hameed, Husam M.] Wassit Univ, Sch Med, Al Kut, Iraq. RP Lesho, EP (reprint author), 3rd Infantry Div, Brigade Combat Team 2, Savannah, GA USA. NR 1 TC 8 Z9 8 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JAN PY 2011 VL 176 IS 1 BP 1 EP 3 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 703XS UT WOS:000286015800001 PM 21305951 ER PT J AU Duran-Stanton, AM Kirk, KL AF Duran-Stanton, Amelia M. Kirk, Kevin L. TI "March Fractures" on a Female Military Recruit SO MILITARY MEDICINE LA English DT Article ID STRESS-FRACTURES; METATARSALS; MANAGEMENT; DIAGNOSIS; RISK AB Stress fractures are caused by repetitive low-impact activities. It is important to have a high index of suspicion in diagnosing and treating stress fractures early for remodeling to occur. This is a case report of a 19-year-old female military recruit with stress fractures of the right foot. The patient had an extended non-weight-bearing treatment that eventually had a successful outcome after allowing the fracture to heal by starting the patient on weight-bearing activities and a "walk-to-run" program. Treatment points in managing stress fractures including female-specific issues are also discussed. C1 [Duran-Stanton, Amelia M.; Kirk, Kevin L.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Duran-Stanton, AM (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 12 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JAN PY 2011 VL 176 IS 1 BP 53 EP 55 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 703XS UT WOS:000286015800010 PM 21305960 ER PT J AU Shen-Gunther, J Ellison, R Kuhens, C Roach, CJ Jarrard, S AF Shen-Gunther, Jane Ellison, Richard Kuhens, Charles Roach, Christopher J. Jarrard, Steve TI Operation Enduring Freedom: Trends in Combat Casualty Care by Forward Surgical Teams Deployed to Afghanistan SO MILITARY MEDICINE LA English DT Article ID SCORE; ARMY AB This study examined the clinical experience of a U.S. Army Forward Surgical Team (FST) deployed to Afghanistan in 2005 and compared the findings with those of 3 previously deployed FSTs. Medical records of all patients evaluated by the FST were abstracted for analysis. Demographically, the cohort (n = 614) was predominantly male (94%), with a median age of 24, and distributed according to the following: disease (8.6%), nonbattle injury (42%), and battle injury (49%). Combat casualties were mostly Afghan National Army or Police (56%) and U.S. military (21%). Predominant wounding instruments were small arms (34%), improvised explosive devices (33%), and rocket-propelled grenades (15%). Anatomical sites of battle injury were extremities (38%), external soft tissue (35%), and head/neck/torso (28%). Operative procedures for combat injury (n = 227) were primarily orthopedic (45%) or thoracic/abdominal (36%). Combat casualty statistics provide insight to trauma epidemiology, patterns, and trends vital for surgical management. Workload statistics guides the structuring, training, and employment of FSTs. C1 [Shen-Gunther, Jane] Brooke Army Med Ctr, Dept Clin Invest, ATTN MCHE CI, Ft Sam Houston, TX 78234 USA. [Ellison, Richard] Off Corps Surg, Hlth Affairs, Airborne Corps 18, Ft Bragg, NC 28310 USA. [Kuhens, Charles] Walter Reed Army Med Ctr, Dept Nursing, Washington, DC 20307 USA. [Roach, Christopher J.] McDonald Army Hlth Ctr, Orthoped Clin, Ft Eustis, VA 23604 USA. [Jarrard, Steve] Winn Army Community Hosp, Dept Surg, Ft Stewart, GA 31314 USA. RP Shen-Gunther, J (reprint author), Brooke Army Med Ctr, Dept Clin Invest, ATTN MCHE CI, 3400 Rawley E Chambers Ave,Suite A, Ft Sam Houston, TX 78234 USA. NR 19 TC 17 Z9 18 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JAN PY 2011 VL 176 IS 1 BP 67 EP 78 PG 12 WC Medicine, General & Internal SC General & Internal Medicine GA 703XS UT WOS:000286015800013 PM 21305963 ER PT J AU Co, EM Keen, EF Aldous, WK AF Co, Edgie-Mark Keen, Edward F., III Aldous, Wade K. TI Prevalence of Methicillin-Resistant Staphylococcus aureus in a Combat Support Hospital in Iraq SO MILITARY MEDICINE LA English DT Article ID UNITED-STATES; INFECTIONS; BACTERIA; MRSA; COMPLICATIONS; COLONIZATION; AFGHANISTAN; CALIFORNIA; RECOVERY; DISEASE AB Methicillin-resistant Staphylococcus aureus (MRSA) in health-care settings results in life-threatening infections. We examined the incidence of MRSA at the combat support hospital located at the Ibn Sina Hospital in Baghdad, Iraq. We compiled isolate data from 2005 to 2009 characterizing antibiotic susceptibilities, annual trends, patient populations, infection sites, and hospital locations. Approximately 46.1% of S. aureus were MRSA, with increase in numbers of yearly isolates. M RSA was isolated in higher numbers from U.S. military personnel. Non-U.S. patient isolates displayed higher antibiotic susceptibility compared to U.S. military personnel isolates. Outpatient clinic, forward operating bases, and intermediate care ward 1 isolated the most MRSA. Common isolation sites were wound and skin cultures. Community-acquired MRSA was likely present in 291 out of 303 isolates based on antibiotic susceptibility. Our data suggests that most MRSA were community-acquired with limited nosocomial spread. We recommend increases in combat support hospital molecular lab capability to rapidly identify both M RSA categories. C1 [Co, Edgie-Mark] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Keen, Edward F., III] 28th Combat Support Hosp, Lab Serv, Sather Air Base, APO, AE 09321 USA. [Aldous, Wade K.] Brooke Army Med Ctr, Dept Pathol, Ft Sam Houston, TX 78234 USA. [Aldous, Wade K.] Brooke Army Med Ctr, Area Lab Serv, Ft Sam Houston, TX 78234 USA. RP Co, EM (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. NR 30 TC 6 Z9 6 U1 1 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JAN PY 2011 VL 176 IS 1 BP 89 EP 93 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 703XS UT WOS:000286015800016 PM 21305966 ER PT J AU Skinner, CG Patel, MM Thomas, JD Miller, MA AF Skinner, Carl G. Patel, Manish M. Thomas, Jerry D. Miller, Michael A. TI Understanding Common Statistical Methods, Part I: Descriptive Methods, Probability, and Continuous Data SO MILITARY MEDICINE LA English DT Article AB Statistical methods are pervasive in medical research and general medical literature. Understanding general statistical concepts will enhance our ability to critically appraise the current literature and ultimately improve the delivery of patient care. This article intends to provide an overview of the common statistical methods relevant to medicine. C1 [Skinner, Carl G.] Madigan Army Med Ctr, Dept Emergency Med, Tacoma, WA 98431 USA. [Patel, Manish M.; Thomas, Jerry D.] Emory Univ, Sch Med, Dept Emergency Med, Atlanta, GA 30322 USA. [Miller, Michael A.] Tripler Army Med Ctr, Dept Emergency Med, Honolulu, HI 96859 USA. RP Skinner, CG (reprint author), Madigan Army Med Ctr, Dept Emergency Med, Bldg 9040,Fitzsimmons Dr, Tacoma, WA 98431 USA. NR 2 TC 0 Z9 0 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JAN PY 2011 VL 176 IS 1 BP 99 EP 102 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 703XS UT WOS:000286015800018 PM 21305968 ER PT J AU Hamilton, LR George, DL Scoville, SL Hospenthal, DR Griffith, ME AF Hamilton, Lanette R. George, Dena L. Scoville, Stephanie L. Hospenthal, Duane R. Griffith, Matthew E. TI PCR for Rapid Diagnosis of Acute Q Fever at a Combat Support Hospital in Iraq SO MILITARY MEDICINE LA English DT Article ID SEROLOGY AB Acute Q fever is occasionally seen in U.S. military service members deployed to Iraq. Diagnosis relies on serology, which is not available in the combat zone. Improved diagnostic modalities are needed. We performed a pilot study investigating whether Joint Biological Agent Identification and Diagnostic System (JBAIDS), a ruggedized, deployable polymerase chain reaction (PCR) platform, might be useful in the diagnosis of acute Q fever. Patients presenting to a Combat Support Hospital in Iraq with undifferentiated fever had blood drawn for Q fever PCR and these results were compared with serology. PCR was positive in 6 of 9 patients with acute Q fever by serology and negative in all 9 patients with negative serology. These results suggest that PCR using the JBAIDS platform could be of use in the diagnosis of Q fever in deployed settings. Further research into this modality is warranted. C1 [Hamilton, Lanette R.] Tripler Army Med Ctr, MCHK DP, Honolulu, HI 96859 USA. [George, Dena L.] Darnall Army Med Ctr, Ft Hood, TX 76544 USA. [Scoville, Stephanie L.] USA, Ctr Hlth Promot & Prevent Med, Directorate Epidemiol & Dis Surveillance, Aberdeen Proving Ground, MD 21010 USA. [Hospenthal, Duane R.; Griffith, Matthew E.] Brooke Army Med Ctr, Dept Med, MCHE MD, Ft Sam Houston, TX 78234 USA. RP Hamilton, LR (reprint author), Tripler Army Med Ctr, MCHK DP, Microbiol Rm 2H211,1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 8 TC 6 Z9 6 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JAN PY 2011 VL 176 IS 1 BP 103 EP 105 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 703XS UT WOS:000286015800019 PM 21305969 ER PT J AU Dissanayake, STM Onal, H Westervelt, JD AF Dissanayake, Sahan T. M. Oenal, Hayri Westervelt, James D. TI Optimum Selection of Conservation Reserves: Extensions to Multiple Land Use SO MILITARY OPERATIONS RESEARCH LA English DT Article ID PROGRAMMING APPROACH; ALGORITHMS; NETWORK; CONNECTIVITY; DESIGN AB Military installations are required to protect remnants of suitable habitat areas for rare, threatened, or endangered species in the U.S. while simultaneously addressing land demands to support growing needs for new and conventional training requirements. This leads to an increased pressure to manage federal lands in optimal ways that balance competing objectives and land uses. Mathematical programming methods, in particular linear integer programming, have been used widely in the biological conservation and reserve design literature. Most of the recent works have focused on one specific land use, namely species conservation. In many cases, however, it is important to simultaneously consider multiple land uses within a landscape. We introduce a multiple land use allocation model that includes spatial and ecological criteria and highlight two extensions: a multiple land use meta-clustering model and a multiple land use proximity-to-roads model. A large-scale real data set for the area surrounding Fort Benning (Georgia) is used to optimally select conservation management areas and military training areas. We believe this approach will contribute to the ability of land managers at installations to extract more overall utility from military installation training and testing areas. C1 [Dissanayake, Sahan T. M.; Oenal, Hayri] Univ Illinois, Urbana, IL 61801 USA. [Westervelt, James D.] USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Washington, DC USA. RP Dissanayake, STM (reprint author), Univ Illinois, Urbana, IL 61801 USA. OI Dissanayake, Sahan/0000-0002-4342-5979 FU US Army Engineer Research and Development Center-Construction Engineering Research Laboratory (ERDC-CERL), Great Rivers Cooperative Ecosystem Studies Unit [W9132T-10-2-0016]; USDA National Institute of Food and Agriculture [ILLU-470-370] FX The authors express their gratitude to the participants of Session 3061 at the Agricultural and Applied Economics Association Annual Meeting in August 2009, the program for Environmental and Resource Economics (pERE) workshop at University of Illinois, and two anonymous reviewers for valuable comments and suggestions on an earlier draft of this manuscript. The funding for this research was provided by US Army Engineer Research and Development Center-Construction Engineering Research Laboratory (ERDC-CERL), Great Rivers Cooperative Ecosystem Studies Unit, Agreement No. W9132T-10-2-0016. In addition to the ERDC-CERL support, partial support from the USDA National Institute of Food and Agriculture, Hatch project # ILLU-470-370 is also acknowledged. NR 28 TC 4 Z9 4 U1 0 U2 6 PU MILITARY OPERATIONS RESEARCH SOC PI ALEXANDRIA PA 1703 N BEAUREGARD ST, STE 450, ALEXANDRIA, VA 22311-1717 USA SN 0275-5823 J9 MIL OPER RES JI Mil. Oper. Res. PY 2011 VL 16 IS 1 BP 65 EP 76 DI 10.5711/1082598316165 PG 12 WC Operations Research & Management Science SC Operations Research & Management Science GA 768JD UT WOS:000290929300005 ER PT J AU Kim, PY Britt, TW Klocko, RP Riviere, LA Adler, AB AF Kim, Paul Y. Britt, Thomas W. Klocko, Robert P. Riviere, Lyndon A. Adler, Amy B. TI Stigma, Negative Attitudes About Treatment, and Utilization of Mental Health Care Among Soldiers SO MILITARY PSYCHOLOGY LA English DT Article ID PERCEIVED STIGMA; ILLNESS; MILITARY; IRAQ; DEPRESSION; SERVICES; COMBAT; HELP; AFGHANISTAN; PREDICTORS AB Stigma and organizational barriers have been identified as factors for why a small proportion of soldiers with psychological problems seek professional help. In this article, we examine the impact of negative attitudes toward treatment on treatment seeking among soldiers previously deployed to Afghanistan or Iraq (n = 2,623). We asked soldiers with psychological problems questions about stigma, organizational barriers, negative attitudes toward treatment, and whether they sought treatment for their psychological problems. We found that negative attitudes about treatment inversely predicted treatment seeking. These results provide a more comprehensive examination of reasons that soldiers do not seek needed treatment and highlight the need for policy aimed at reducing negative attitudes toward mental health treatment. C1 [Kim, Paul Y.] Walter Reed Army Inst Res, Dept Mil Psychiat, Silver Spring, MD 20910 USA. [Britt, Thomas W.] Clemson Univ, Clemson, SC USA. [Adler, Amy B.] Walter Reed Army Inst Res, US Army Med Res Unit Europe, Heidelberg, Germany. RP Kim, PY (reprint author), Walter Reed Army Inst Res, Dept Mil Psychiat, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM paul.kim@amedd.army.mil NR 39 TC 86 Z9 86 U1 1 U2 17 PU LAWRENCE ERLBAUM ASSOC INC-TAYLOR & FRANCIS PI PHILADELPHIA PA 325 CHESTNUT STREET, STE 800, PHILADELPHIA, PA 19106 USA SN 0899-5605 J9 MIL PSYCHOL JI Milit. Psychol. PY 2011 VL 23 IS 1 BP 65 EP 81 DI 10.1080/08995605.2011.534415 PG 17 WC Psychology, Multidisciplinary SC Psychology GA 734YE UT WOS:000288378400006 ER PT J AU Black, SA Gallaway, MS Bell, MR Ritchie, EC AF Black, Sandra A. Gallaway, M. Shayne Bell, Michael R. Ritchie, Elspeth C. TI Prevalence and Risk Factors Associated With Suicides of Army Soldiers 2001-2009 SO MILITARY PSYCHOLOGY LA English DT Article ID MENTAL-HEALTH; UNITED-STATES; COMPLETED SUICIDE; MAJOR DEPRESSION; SEX-DIFFERENCES; MILITARY; BEHAVIOR; AFGHANISTAN; POPULATION; PREVENTION AB Prevalence and risk factors associated with soldiers' suicides 2001-2009 (N = 874) were examined. Army suicide rates increased from 9 per 100,000 in 2001 to 22 per 100,000 in 2009. Soldier suicides were lower than civilians from 2001 to 2007, but higher than civilians after 2007. Army suicides were disproportionately higher for men, deployment experience, and a history of a mental health diagnosis/treatment; and lower for African Americans. Many involved planning (38%), communication (21%), alcohol (19%), or drugs (8%). Many had legal problems (31%), high stress loads (90%), a history of self-injury (10%), and other contributing factors prior to entry into the Army (31%). Implications for understanding suicide among military personnel are discussed. C1 [Black, Sandra A.; Gallaway, M. Shayne; Bell, Michael R.] USA, Behav & Social Hlth Outcomes Program, Publ Hlth Command, Aberdeen Proving Ground, MD USA. [Ritchie, Elspeth C.] Off Army Surg Gen, Washington, DC USA. RP Black, SA (reprint author), 8720 Maravoss Lane, Baltimore, MD 21234 USA. EM sandraablack@comcast.net NR 63 TC 41 Z9 42 U1 3 U2 8 PU LAWRENCE ERLBAUM ASSOC INC-TAYLOR & FRANCIS PI PHILADELPHIA PA 325 CHESTNUT STREET, STE 800, PHILADELPHIA, PA 19106 USA SN 0899-5605 J9 MIL PSYCHOL JI Milit. Psychol. PY 2011 VL 23 IS 4 BP 433 EP 451 DI 10.1080/08995605.2011.590409 PG 19 WC Psychology, Multidisciplinary SC Psychology GA 878LP UT WOS:000299258800006 ER PT J AU Fallesen, JJ Keller-Glaze, H Curnow, CK AF Fallesen, Jon J. Keller-Glaze, Heidi Curnow, Christina K. TI A Selective Review of Leadership Studies in the US Army SO MILITARY PSYCHOLOGY LA English DT Article ID PERFORMANCE; MODEL AB This article provides an overview of Army leadership studies and highlights past, current, and future directions for military leadership studies within the U. S. Army. We discuss research on the conceptualization and measurement of military leadership, as well as leader development and situational leadership. Specifically, we note that the Army's conceptualization of leadership has evolved from job-analytic approaches toward competency-based approaches; that measurement of leadership has shifted from cognitive factors to interpersonal competencies; that leader development has focused on preparing leaders for the full spectrum of operations; and that focus on contextual factors has led to increased research in situational leadership. C1 [Keller-Glaze, Heidi; Curnow, Christina K.] ICF Int, Fairfax, VA 22031 USA. [Fallesen, Jon J.] Ctr Army Leadership, Ft Leavenworth, KS USA. RP Keller-Glaze, H (reprint author), ICF Int, 9300 Lee Highway, Fairfax, VA 22031 USA. EM HKeller-Glaze@icfi.com NR 44 TC 5 Z9 5 U1 1 U2 10 PU LAWRENCE ERLBAUM ASSOC INC-TAYLOR & FRANCIS PI PHILADELPHIA PA 325 CHESTNUT STREET, STE 800, PHILADELPHIA, PA 19106 USA SN 0899-5605 J9 MIL PSYCHOL JI Milit. Psychol. PY 2011 VL 23 IS 5 SI SI BP 462 EP 478 DI 10.1080/08995605.2011.600181 PG 17 WC Psychology, Multidisciplinary SC Psychology GA 878LS UT WOS:000299259100002 ER PT J AU Halpin, SM AF Halpin, Stanley M. TI Historical Influences on the Changing Nature of Leadership Within the Military Environment SO MILITARY PSYCHOLOGY LA English DT Article AB Contemporary reviews of leadership research have called attention to the importance of studying the organizational context in which leadership unfolds. Researchers have also noted the need for increasingly sophisticated studies of leadership processes within complex and challenging environments. These calls have particular relevance for those who study leadership within the military environment. This article summarizes historical changes that have influenced the context of leadership within the military environment. It discusses the implications of these historical events for the content of future research on military leadership. C1 [Halpin, Stanley M.] USA, Ft Leavenworth Res Unit, Res Inst Behav & Social Sci, Ft Leavenworth, KS USA. RP Halpin, SM (reprint author), 3319 Rivercrest Court, Midland, MI 48640 USA. EM smhalpin@pair.com NR 43 TC 3 Z9 4 U1 1 U2 5 PU LAWRENCE ERLBAUM ASSOC INC-TAYLOR & FRANCIS PI PHILADELPHIA PA 325 CHESTNUT STREET, STE 800, PHILADELPHIA, PA 19106 USA SN 0899-5605 J9 MIL PSYCHOL JI Milit. Psychol. PY 2011 VL 23 IS 5 SI SI BP 479 EP 488 DI 10.1080/08995605.2011.600138 PG 10 WC Psychology, Multidisciplinary SC Psychology GA 878LS UT WOS:000299259100003 ER PT J AU Connaughton, S Shuffler, M Goodwin, GF AF Connaughton, Stacey Shuffler, Marissa Goodwin, Gerald F. TI Leading Distributed Teams: The Communicative Constitution of Leadership SO MILITARY PSYCHOLOGY LA English DT Article ID SHARED MENTAL MODELS; VIRTUAL TEAMS; DISPERSED COLLABORATION; PERFORMANCE; IMPACT; INFORMATION; FUTURE; TIME; ORGANIZATIONS; METAANALYSIS AB A key aspect of leadership effectiveness across geographical distance is communication. However, researchers are only beginning to empirically explore the communicative aspects and constitution of military units and leadership in these contexts. This article highlights communicative features and processes in studies of distributed military units, particularly in those that examine leadership. We discuss aspects of military leadership that are in particular need of a communicative lens, including the communication of command intent, sensemaking, and leading across multiple cultures. We present future research directions that will further advance our understanding of the inextricable relationship between leadership and communication in distributed contexts. New technologies, advanced capabilities, and increased involvement of non-state actors are leading to a rapidly expanding, non-linear, multi-dimensional battlespace. Operations are becoming more distributed in time, space, and purpose and increasingly joint, multinational, and interagency in nature. (Department of the Army, 2009) C1 [Connaughton, Stacey] Purdue Univ, Brian Lamb Sch Commun, W Lafayette, IN 47907 USA. [Shuffler, Marissa] Univ Cent Florida, ICF Int, Orlando, FL 32816 USA. [Shuffler, Marissa] Univ Cent Florida, Inst Simulat & Training, Orlando, FL 32816 USA. [Goodwin, Gerald F.] USA, Res Inst Behav & Social Sci, Arlington, VA USA. RP Connaughton, S (reprint author), Purdue Univ, Brian Lamb Sch Commun, Beering Hall,Room 2114,100 N Univ St, W Lafayette, IN 47907 USA. EM sconnaug@purdue.edu NR 111 TC 1 Z9 1 U1 7 U2 27 PU LAWRENCE ERLBAUM ASSOC INC-TAYLOR & FRANCIS PI PHILADELPHIA PA 325 CHESTNUT STREET, STE 800, PHILADELPHIA, PA 19106 USA SN 0899-5605 J9 MIL PSYCHOL JI Milit. Psychol. PY 2011 VL 23 IS 5 SI SI BP 502 EP 527 DI 10.1080/08995605.2011.600147 PG 26 WC Psychology, Multidisciplinary SC Psychology GA 878LS UT WOS:000299259100005 ER PT J AU Lindsay, DR Day, DV Halpin, SM AF Lindsay, Douglas R. Day, David V. Halpin, Stanley M. TI Shared Leadership in the Military: Reality, Possibility, or Pipedream? SO MILITARY PSYCHOLOGY LA English DT Article ID WORK TEAMS; CONTEXT; EVENTS AB Shared leadership involves building a broader and deeper capacity for leadership that goes beyond a formally appointed leader. Several models of team leadership are reviewed, distinguishing between the leadership of teams from leadership in teams. Shared leadership is a variant of the latter in which everyone on the team is responsible for leadership and where leadership emerges through patterned interactions of team members. Overall, shared leadership appears to be a possibility for the military-and one that is needed because of the increasing complexity of missions-but efforts need to be undertaken to incorporate it into formal training and doctrine. C1 [Lindsay, Douglas R.] USAF Acad, HQ USAFA DFBL, Dept Behav Sci & Leadership, Colorado Springs, CO 80840 USA. [Day, David V.] Univ Western Australia, Sch Business, Perth, WA 6009, Australia. [Halpin, Stanley M.] USA, Ft Leavenworth Res Unit, Inst Behav & Social Sci, Ft Leavenworth, KS USA. RP Lindsay, DR (reprint author), USAF Acad, HQ USAFA DFBL, Dept Behav Sci & Leadership, 2354 Fairchild Dr,Suite 6L-101, Colorado Springs, CO 80840 USA. EM douglas.lindsay@usafa.edu NR 44 TC 5 Z9 5 U1 5 U2 15 PU LAWRENCE ERLBAUM ASSOC INC-TAYLOR & FRANCIS PI PHILADELPHIA PA 325 CHESTNUT STREET, STE 800, PHILADELPHIA, PA 19106 USA SN 0899-5605 J9 MIL PSYCHOL JI Milit. Psychol. PY 2011 VL 23 IS 5 SI SI BP 528 EP 549 DI 10.1080/08995605.2011.600150 PG 22 WC Psychology, Multidisciplinary SC Psychology GA 878LS UT WOS:000299259100006 ER PT J AU Jennings, PL Hannah, ST AF Jennings, Peter L. Hannah, Sean T. TI The Moralities of Obligation and Aspiration: Towards a Concept of Exemplary Military Ethics and Leadership SO MILITARY PSYCHOLOGY LA English DT Article ID SELF-EFFICACY; PERFORMANCE; IDENTITY; BEHAVIOR; WORK; ORGANIZATIONS; PERCEPTIONS; PERSONALITY; APPROBATION; ATTITUDES AB A fundamental tension in military ethics is not just how to prevent unethical behavior, but also how to inspire supererogatory conduct "above and beyond the call of duty." In this article, we provide a conceptual analysis and integrative framework for understanding the dynamics of military ethics based on two contrasting but complementary moralities-moralities of obligation and aspiration; and two types of moral motivation-rule-following and identity-conferring. We then provide analysis of the exemplary leadership required to inform and inspire military members to realize the aspirations embedded in an exemplary military ethic. C1 [Jennings, Peter L.; Hannah, Sean T.] US Mil Acad, Ctr Army Profess & Eth, West Point, NY 10996 USA. RP Jennings, PL (reprint author), US Mil Acad, Ctr Army Profess & Eth, 646 Swift Rd, West Point, NY 10996 USA. EM Peter.Jennings@usma.edu NR 82 TC 2 Z9 2 U1 2 U2 7 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0899-5605 EI 1532-7876 J9 MIL PSYCHOL JI Milit. Psychol. PY 2011 VL 23 IS 5 SI SI BP 550 EP 571 DI 10.1080/08995605.2011.600158 PG 22 WC Psychology, Multidisciplinary SC Psychology GA 878LS UT WOS:000299259100007 ER PT J AU Mitchell, MM Gallaway, MS Millikan, A Bell, MR AF Mitchell, Mary M. Gallaway, M. Shayne Millikan, Amy Bell, Michael R. TI Combat Stressors Predicting Perceived Stress Among Previously Deployed Soldiers SO MILITARY PSYCHOLOGY LA English DT Article ID SOCIAL SUPPORT; WAR ZONE; COHESION; DUTY AB While combat exposures are considered principle stressors in developing mental health problems, research suggests social support can reduce this risk. Using data from 1,592 previously deployed soldiers, we found five classes of soldiers based on their patterns of responses to items measuring perceived stress. In subsequent analyses, we found increased combat exposure predicted membership in classes with greater combat-related stress, while greater unit cohesion predicted membership in classes with lower perceived stress. Also, greater willingness to report misconduct predicted greater unit cohesion. Results suggest that unit cohesion plays a vital role in the reduction of perceived stress among soldiers. C1 [Mitchell, Mary M.; Gallaway, M. Shayne; Millikan, Amy] USA, Publ Hlth Command, BSHOP, Aberdeen, MD USA. [Bell, Michael R.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. RP Mitchell, MM (reprint author), USA, Publ Hlth Command, BSHOP, 5158 Blackhawk Rd,Bldg 1570, Aberdeen Proving Ground, MD 21010 USA. EM mary.moser.mitchell@us.army.mil NR 30 TC 2 Z9 3 U1 1 U2 2 PU LAWRENCE ERLBAUM ASSOC INC-TAYLOR & FRANCIS PI PHILADELPHIA PA 325 CHESTNUT STREET, STE 800, PHILADELPHIA, PA 19106 USA SN 0899-5605 J9 MIL PSYCHOL JI Milit. Psychol. PY 2011 VL 23 IS 6 BP 573 EP 586 DI 10.1080/08995605.2011.616478 PG 14 WC Psychology, Multidisciplinary SC Psychology GA 878LW UT WOS:000299259500001 ER PT J AU Weingarten, NS Selinger, RLB AF Weingarten, N. Scott Selinger, Robin L. B. TI Atomistic simulation studies of size effects in plasticity: compression of single- and polydomain crystals in two dimensions SO MODELLING AND SIMULATION IN MATERIALS SCIENCE AND ENGINEERING LA English DT Article ID STRAIN-GRADIENT PLASTICITY; RANGE INTERNAL-STRESSES; MOLECULAR-DYNAMICS; LENGTH SCALE; COPPER; DEFORMATION; EVOLUTION; STRENGTH; TENSION; SOLIDS AB We perform atomistic Monte Carlo simulations of a Lennard-Jones crystal under uniaxial compression on single crystal and polycrystalline samples in two dimensions. In single crystals, we observe a size effect in initial yield: smaller samples yield at higher stress. We also find a size effect in the plastic regime which is accounted for by dislocation starvation. Two-dimensional polycrystalline samples are generated using a statistical physics model, and studied under uniaxial compression. The resulting microstructures show higher stress within the grain boundary regions relative to that in the bulk, consistent with theoretical models and experimental results. We also examine the broad distribution of stresses within the polydomain sample and compare with recent experimental observations. While 2D simulations cannot predict behavior of real 3D solids, they are valuable for exploring some of the fundamental mechanisms controlling mechanical response and serve as a testing ground for theories of size effects in plasticity. C1 [Weingarten, N. Scott] Catholic Univ Amer, Dept Phys, Washington, DC 20017 USA. [Selinger, Robin L. B.] Kent State Univ, Inst Liquid Crystal, Kent, OH 44242 USA. [Selinger, Robin L. B.] Kent State Univ, Chem Phys Interdisciplinary Program, Kent, OH 44242 USA. RP Weingarten, NS (reprint author), USA, Res Lab, RDRL WML B, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. OI Selinger, Robin/0000-0002-6519-9685 NR 36 TC 1 Z9 1 U1 0 U2 10 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0965-0393 J9 MODEL SIMUL MATER SC JI Model. Simul. Mater. Sci. Eng. PD JAN PY 2011 VL 19 IS 1 AR 015006 DI 10.1088/0965-0393/19/1/015006 PG 10 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA 695NT UT WOS:000285379000006 ER PT B AU Poisel, RA AF Poisel, Richard A. BA Poisel, RA BF Poisel, RA TI Detection of Signals in Noise SO MODERN COMMUNICATIONS JAMMING: PRINCIPLES AND TECHNIQUES, SECOND EDITION SE Artech House Intelligence and Information Operations Series LA English DT Article; Book Chapter C1 [Poisel, Richard A.] Univ Wisconsin, Madison, WI 53706 USA. [Poisel, Richard A.] USA, Res Dev & Engn Command, Intelligence & Informat Warfare Lab, Washington, DC USA. [Poisel, Richard A.] MIT Sloan Sch Management, Cambridge, MA USA. NR 36 TC 0 Z9 0 U1 0 U2 0 PU ARTECH HOUSE PI NORWOOD PA 685 CANTON ST, NORWOOD, MA 02062 USA BN 978-1-60807-165-4 J9 ARTECH HSE INTEL INF PY 2011 BP 15 EP 120 PG 106 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BUL57 UT WOS:000289749500002 ER PT J AU Fang, X Wallqvist, A Reifman, J AF Fang, Xin Wallqvist, Anders Reifman, Jaques TI Modeling synergistic drug inhibition of Mycobacterium tuberculosis growth in murine macrophages SO MOLECULAR BIOSYSTEMS LA English DT Article ID CONSTRAINT-BASED ANALYSIS; FLUX BALANCE ANALYSIS; METABOLIC MODEL; SALMONELLA-TYPHIMURIUM; INTRACELLULAR GROWTH; BIOCHEMICAL NETWORKS; ISOCITRATE LYASE-1; BIOLOGICAL-SYSTEMS; RECONSTRUCTION; PHARMACOKINETICS AB We developed a metabolism-based systems biology framework to model drug-induced growth inhibition of Mycobacterium tuberculosis in murine macrophage cells. We used it to simulate ex vivo bacterial growth inhibition due to 3-nitropropionate (3-NP) and calculated the corresponding time-and drug concentration-dependent dose-response curves. 3-NP targets the isocitrate lyase 1 (ICL1) and ICL2 enzymes in the glyoxylate shunt, an essential component in carbon metabolism of many important prokaryotic organisms. We used the framework to in silico mimic drugging additional enzymes in combination with 3-NP to understand how synergy can arise among metabolic enzyme targets. In particular, we focused on exploring additional targets among the central carbon metabolism pathways and ascertaining the impact of jointly inhibiting these targets and the ICL1/ICL2 enzymes. Thus, additionally inhibiting the malate synthase (MS) enzyme in the glyoxylate shunt did not produce synergistic effects, whereas additional inhibition of the glycerol-3-phosphate dehydrogenase (G3PD) enzyme showed a reduction in bacterial growth beyond what each single inhibition could achieve. Whereas the ICL1/ICL2-MS pair essentially works on the same branch of the metabolic pathway processing lipids as carbon sources (the glyoxylate shunt), the ICL1/ICL2-G3PD pair inhibition targets different branches among the lipid utilization pathways. This allowed the ICL1/ICL2-G3PD drug combination to synergistically inhibit carbon processing and ultimately affect cellular growth. Our previously developed model for in vitro conditions failed to capture these effects, highlighting the importance of constructing accurate representations of the experimental ex vivo macrophage system. C1 [Fang, Xin; Wallqvist, Anders; Reifman, Jaques] USA, Med Res & Materiel Command, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. RP Reifman, J (reprint author), USA, Med Res & Materiel Command, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. EM jaques.reifman@us.army.mil OI wallqvist, anders/0000-0002-9775-7469 FU U.S. Army Assistant Secretary of the Army for Acquisition, Logistics, and Technology (ASAALT) FX We thank Dr F. Vital-Lopez for a careful reading of the manuscript. This project was funded in part by a competitive In-house Laboratory Independent Research (ILIR) award by the U.S. Army Assistant Secretary of the Army for Acquisition, Logistics, and Technology (ASAALT). The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or the U.S. Department of Defense. This paper has been approved for public release with unlimited distribution. NR 59 TC 11 Z9 12 U1 1 U2 6 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1742-206X J9 MOL BIOSYST JI Mol. Biosyst. PY 2011 VL 7 IS 9 BP 2622 EP 2636 DI 10.1039/c1mb05106g PG 15 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 804IU UT WOS:000293648300012 PM 21713281 ER PT S AU Burks, SD Doe, JM AF Burks, Stephen D. Doe, Joshua M. BA Braun, JJ BF Braun, JJ TI GStreamer as a framework for image processing applications in image fusion SO MULTISENSOR, MULTISOURCE INFORMATION FUSION: ARCHITECTURES, ALGORITHMS, AND APPLICATIONS 2011 SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Multisensor, Multisource Information Fusion - Architectures, Algorithms, and Applications CY APR 27-28, 2011 CL Orlando, FL AB Multiple source band image fusion can sometimes be a multi-step process that consists of several intermediate image processing steps. Typically, each of these steps is required to be in a particular arrangement in order to produce a unique output image. GStreamer is an open source, cross platform multimedia framework, and using this framework, engineers at NVESD have produced a software package that allows for real time manipulation of processing steps for rapid prototyping in image fusion. C1 [Burks, Stephen D.; Doe, Joshua M.] USA, RDECOM, CERDEC, Night Vision & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Burks, SD (reprint author), USA, RDECOM, CERDEC, Night Vision & Elect Sensors Directorate, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. RI Doe, Jane/B-8500-2015 NR 8 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-638-7 J9 PROC SPIE PY 2011 VL 8064 AR 80640M DI 10.1117/12.884797 PG 7 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA BXX74 UT WOS:000297514600017 ER PT S AU Kelley, TD Avery, E McGhee, SM AF Kelley, T. D. Avery, E. McGhee, S. M. BA Braun, JJ BF Braun, JJ TI The Perception Problem and the Impact on Robotics and Computer Vision SO MULTISENSOR, MULTISOURCE INFORMATION FUSION: ARCHITECTURES, ALGORITHMS, AND APPLICATIONS 2011 SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Multisensor, Multisource Information Fusion - Architectures, Algorithms, and Applications CY APR 27-28, 2011 CL Orlando, FL DE Perception; Robotics; Computer Vision ID FACE-RECOGNITION ALGORITHMS AB Why is there a perception problem in robotics? Given the increases in the speed of computer hardware and technology which has followed Moore's Law, why haven't there been commensurate advances in computer perception technology, which would enable a robot to respond appropriately to its environment? Perhaps the algorithms used for perception are not appropriate for the problem? The computer vision problem was assumed to be easy, and the supposedly more difficult challenges of problem solving and decision making were tackled first. As it turned out, problem solving and decision making were handled relatively easily by symbolic representations and predicate logic, however, the perception of the real world turned out to be much more difficult. What are the algorithms that have been used for perception in robotics and why do they sometimes fail at reproducing human-like behavior? How can we learn from biological systems which, through evolution, have made great advances in solving the difficult problems of perception and classification? C1 [Kelley, T. D.; Avery, E.; McGhee, S. M.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Kelley, TD (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RI McGhee, Sarah/A-6460-2013 OI McGhee, Sarah/0000-0003-1025-5915 NR 12 TC 0 Z9 0 U1 0 U2 4 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-638-7 J9 PROC SPIE PY 2011 VL 8064 AR 80640B DI 10.1117/12.887014 PG 8 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA BXX74 UT WOS:000297514600008 ER PT S AU Risko, KKD Hester, CF AF Risko, Kelly K. D. Hester, Charles F. BA Braun, JJ BF Braun, JJ TI Learned Fusion Operators Based on Matrix Completion SO MULTISENSOR, MULTISOURCE INFORMATION FUSION: ARCHITECTURES, ALGORITHMS, AND APPLICATIONS 2011 SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Multisensor, Multisource Information Fusion - Architectures, Algorithms, and Applications CY APR 27-28, 2011 CL Orlando, FL DE fusion; matrix completion; class map AB The efficient and timely management of imagery captured in the battlefield requires methods capable of searching the voluminous databases and extracting highly symbolic concepts. When processing images, a semantic and definition gap exists between machine representations and the user's language. Based on matrix completion techniques, we present a fusion operator that fuses imagery and expert knowledge provided by user inputs during post analysis. Specifically, an information matrix is formed from imagery and a class map as labeled by an expert. From this matrix an image operator is derived for the extraction/prediction of information from future imagery. We will present results using this technique on single mode data. C1 [Risko, Kelly K. D.; Hester, Charles F.] US Army Res Dev & Engn Command, Weap Dev & Integrat Directorate, Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA. RP Risko, KKD (reprint author), US Army Res Dev & Engn Command, Weap Dev & Integrat Directorate, Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-638-7 J9 PROC SPIE PY 2011 VL 8064 AR 80640K DI 10.1117/12.885011 PG 12 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA BXX74 UT WOS:000297514600015 ER PT S AU Finch, AS Jacob, CM Sumner, JJ AF Finch, Amethist S. Jacob, Christina M. Sumner, James J. BE Kobayashi, N Ouchen, F Rau, I TI DNA Architectures for Templated Material Growth SO NANOBIOSYSTEMS: PROCESSING, CHARACTERIZATION, AND APPLICATIONS IV SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Nanobiosystems - Processing, Characterization, and Applications IV CY AUG 21-22, 2011 CL San Diego, CA SP SPIE DE DNA; Directed Assembly; Nanoarchitectures; Nanomaterials; DNA Templated Assembly; AFM ID NANOTECHNOLOGY; NANOSTRUCTURES; COMPLEX AB A methodology that allows for the coupling of biology and electronic materials is presented, where double stranded DNA serves as a template for electronic material growth. Self-assembled DNA structures allow for a variety of patterns to be achieved on the nanometer size scale. These DNA architectures allow for feature sizes that are difficult to achieve using conventional patterning techniques. Herein, the procedures for the creation of self-assembled DNA nanostructures in aqueous and non-aqueous media are described, and these structures are subsequently deposited onto substrates of interest. DNA self assembly under non-aqueous conditions has yet to be presented in literature, and is necessary if unwanted oxidation of certain electronic substrates is to be avoided. Solubilization of the DNA in non-aqueous solvents is achieved by replacing charge stabilizing salts with surfactants. Retention of DNA hierarchical structure under both conditions will be presented by observing the structures using AFM imaging and circular dichroism spectroscopic studies. C1 [Finch, Amethist S.; Jacob, Christina M.; Sumner, James J.] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Finch, AS (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RI Finch, Amethist/H-9510-2013 OI Finch, Amethist/0000-0002-4650-6301 NR 15 TC 1 Z9 1 U1 1 U2 4 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-713-1 J9 PROC SPIE PY 2011 VL 8103 AR 81030B DI 10.1117/12.893883 PG 9 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Optics SC Engineering; Science & Technology - Other Topics; Optics GA BXY45 UT WOS:000297621100007 ER PT B AU Cornwell, CF Allen, JB Marsh, CP Carlson, TA Stynoski, PB Newcomb, BA Masters, B Ebeling, RM Welch, CR AF Cornwell, Charles F. Allen, Jeffrey B. Marsh, Charles P. Carlson, Thomas A. Stynoski, Peter B. Newcomb, Bradley A. Masters, Benjamin Ebeling, Robert M. Welch, Charles R. BE Laudon, M Romanowicz, B TI Brittle Ductile Transition in Carbon Nanotube Bundles SO NANOTECHNOLOGY 2011: ELECTRONICS, DEVICES, FABRICATION, MEMS, FLUIDICS AND COMPUTATIONAL, NSTI-NANOTECH 2011, VOL 2 LA English DT Proceedings Paper CT NSTI Nanotechnology Conference and Expo CY JUN 13-16, 2011 CL Boston, MA SP Clean Technol & Sustainable Ind Org, European Patent Off, Greenberg Traurig, Innovat & Mat Sci Inst, Jackson Walker LLP, Linde Nanomaterials, Lockheed Martin, Nano Sci & Technol Inst, Nano Tech Japan, NanoEurope Fair & Conf, Nanpolis Suzhou, Suzhou Nanotech Co Ltd, Natl Inst Standards & Technol, Ctr Nanoscale Sci & Technol, Fraunhofer, Res Germany, TechConnect, Technol Innovat Program, Canadian Trade Commiss Serv, Italian Trade Commiss DE carbon nanotubes; molecular simulation; mechanical properties; nanofibers; load transfer ID MOLECULAR-DYNAMICS; ROPES; MECHANISM; LOAD AB The superior strength and stiffness of carbon nanotubes (CNTs) make them attractive for many structural applications. While the strength and stiffness of CNTs are extremely high, to date, fibers of aligned CNTs have been found to be far weaker than the constituent CNTs. The intermolecular interactions between the CNTs in the fibers are governed by weak van der Waals forces resulting in slippage between CNTs that occurs at tensions well below the breaking strength of the CNTs. Both theoretical and experimental studies show that introducing chemical bonds between the CNTs increases load transfer and prevents the CNTs from slipping. C1 [Cornwell, Charles F.; Allen, Jeffrey B.; Marsh, Charles P.; Carlson, Thomas A.; Stynoski, Peter B.; Newcomb, Bradley A.; Masters, Benjamin; Ebeling, Robert M.; Welch, Charles R.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Cornwell, CF (reprint author), US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM charles.f.cornwell@usace.army.mil FU U.S. Army Engineer Research and Development Center Research Program "Molecular-Designed Carbon Nanotube Filaments, Membranes, and Coatings''; HPC Challenge Project "Molecular Dynamics Simulations to Underpin the Design and Development of High-Performance Carbon-Nanotube-Based Filaments, Membranes, and Coatings" FX This study gratefully acknowledges funding support from the U.S. Army Engineer Research and Development Center Research Program "Molecular-Designed Carbon Nanotube Filaments, Membranes, and Coatings," the HPC Challenge Project "Molecular Dynamics Simulations to Underpin the Design and Development of High-Performance Carbon-Nanotube-Based Filaments, Membranes, and Coatings," and allocation of computer time from the Department of Defense High Performance Computing Modernization Program. NR 12 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-7139-3 PY 2011 BP 100 EP 103 PG 4 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA BG9XB UT WOS:000394060800026 ER PT J AU Kateb, B Chiu, K Black, KL Yamamoto, V Khalsa, B Ljubimova, JY Ding, H Patil, R Portilla-Arias, JA Modo, M Moore, DF Farahani, K Okun, MS Prakash, N Neman, J Ahdoot, D Grundfest, W Nikzad, S Heiss, JD AF Kateb, Babak Chiu, Katherine Black, Keith L. Yamamoto, Vicky Khalsa, Bhavraj Ljubimova, Julia Y. Ding, Hui Patil, Rameshwar Portilla-Arias, Jose Antonio Modo, Mike Moore, David F. Farahani, Keyvan Okun, Michael S. Prakash, Neal Neman, Josh Ahdoot, Daniel Grundfest, Warren Nikzad, Shouleh Heiss, John D. TI Nanoplatforms for constructing new approaches to cancer treatment, imaging, and drug delivery: What should be the policy? SO NEUROIMAGE LA English DT Article DE Nanoplatforms; Nanotechnology; Image-guided therapy; Nanomedicine; Nanoneurosurgery; Nanostructures; Contrast agents; Nanoparticles; Nanotechnology policy; Nano-radiology; Nano-neuroscience; Nano-neurology ID NEPHROGENIC SYSTEMIC FIBROSIS; IRON-OXIDE NANOPARTICLES; FUNCTIONALIZED CARBON NANOTUBES; MAGNETIC-RESONANCE TRACKING; BLOOD-BRAIN-BARRIER; MRI CONTRAST AGENTS; PLURONIC((R)) BLOCK-COPOLYMERS; SEMICONDUCTOR QUANTUM DOTS; VX-2 RABBIT TUMORS; SIALYL-LEWIS-X AB Nanotechnology is the design and assembly of submicroscopic devices called nanoparticles, which are 1-100 nm in diameter. Nanomedicine is the application of nanotechnology for the diagnosis and treatment of human disease. Disease-specific receptors on the surface of cells provide useful targets for nanoparticles. Because nanoparticles can be engineered from components that (1) recognize disease at the cellular level, (2) are visible on imaging studies, and (3) deliver therapeutic compounds, nanotechnology is well suited for the diagnosis and treatment of a variety of diseases. Nanotechnology will enable earlier detection and treatment of diseases that are best treated in their initial stages, such as cancer. Advances in nanotechnology will also spur the discovery of new methods for delivery of therapeutic compounds, including genes and proteins, to diseased tissue. A myriad of nanostructured drugs with effective site-targeting can be developed by combining a diverse selection of targeting, diagnostic, and therapeutic components. Incorporating immune target specificity with nanostructures introduces a new type of treatment modality, nano-immunochemotherapy, for patients with cancer. In this review, we will discuss the development and potential applications of nanoscale platforms in medical diagnosis and treatment. To impact the care of patients with neurological diseases, advances in nanotechnology will require accelerated translation to the fields of brain mapping, CNS imaging, and nanoneurosurgery. Advances in nanoplatform, nano-imaging, and nano-drug delivery will drive the future development of nanomedicine, personalized medicine, and targeted therapy. We believe that the formation of a science, technology, medicine law-healthcare policy (STML) hub/center, which encourages collaboration among universities, medical centers, US government, industry, patient advocacy groups, charitable foundations, and philanthropists, could significantly facilitate such advancements and contribute to the translation of nanotechnology across medical disciplines. (C) 2010 Elsevier Inc. All rights reserved. C1 [Kateb, Babak; Moore, David F.; Okun, Michael S.; Prakash, Neal; Grundfest, Warren; Nikzad, Shouleh; Heiss, John D.] IBMISPS, W Hollywood, CA 90046 USA. [Kateb, Babak; Ahdoot, Daniel; Grundfest, Warren; Nikzad, Shouleh] Brain Mapping Fdn, W Hollywood, CA 90046 USA. [Kateb, Babak] Univ So Calif, Viterbi Sch Engn, Los Angeles, CA 90089 USA. [Kateb, Babak; Yamamoto, Vicky; Nikzad, Shouleh] Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA. [Kateb, Babak; Black, Keith L.; Ljubimova, Julia Y.; Ding, Hui; Patil, Rameshwar; Portilla-Arias, Jose Antonio] Cedars Sinai Med Ctr, Maxine Dunitz Neurosurg Inst, Los Angeles, CA 90048 USA. [Chiu, Katherine; Khalsa, Bhavraj] Univ Calif Irvine, Sch Med, Irvine, CA 92697 USA. [Moore, David F.] Walter Reed Army Med Ctr, DVBIC, Washington, DC 20307 USA. [Modo, Mike] Kings Coll London, London WC2R 2LS, England. [Neman, Josh; Grundfest, Warren] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA. [Okun, Michael S.] Univ Florida, Movement Disorders Ctr, Dept Neurol, Gainesville, FL 32610 USA. [Okun, Michael S.] Univ Florida, Movement Disorders Ctr, Dept Neurosurg, Gainesville, FL 32610 USA. [Prakash, Neal] Univ Hawaii, John A Burns Sch Med, Manoa, HI 96813 USA. [Farahani, Keyvan] NCI, Bethesda, MD 20892 USA. [Heiss, John D.] NINDS, Bethesda, MD 20824 USA. [Nikzad, Shouleh] CALTECH, Jet Prop Lab, Pasadena, CA 91109 USA. RP Kateb, B (reprint author), IBMISPS, 8159 Santa Monica Blvd,Suite 200, W Hollywood, CA 90046 USA. EM Bkateb@ibmisps.org RI Modo, Michel/E-5170-2012; Farahani, Keyvan/G-9069-2012; PORTILLA-ARIAS, JOSE/C-3223-2008; OI PORTILLA-ARIAS, JOSE/0000-0003-1105-1842; Khalsa, Bhavraj/0000-0003-0915-931X; Okun, Michael/0000-0002-6247-9358; Heiss, John/0000-0002-3890-0165; Modo, Michel/0000-0003-4436-735X FU NIH/NCI [R01 CA123495]; NIBIB [1 P20 EB007076-01] FX We would like to specially thank Dr. Eggehard Holler for his contribution to the paper. Our thanks and appreciation to Dr. Nakissa Sadrieh for her permission to include the table on FDA-approved drugs in the nanometer scale. We would also like to acknowledge Julia Ljubimova and Mike Modo's grant support from the NIH/NCI R01 CA123495 grant and NIBIB (Quantum Grant-1 P20 EB007076-01), respectively. Dr. Modo's NIBIB Quantum Grant is directed towards tissue engineering and brain research (PEG-based hydrogels, etc.). We acknowledge Dr. Behnam Badie for his editorial contributions and Rohit Majumdar and Adrian Au for their time and help in conducting the literature search. This work is also made possible through a generous contribution of the Brain Mapping Foundation. The contents of this paper are solely the responsibility of the authors and represent the official position of the IBMISP Society. The contents do not represent the official views of NINDS/NIH and NCI/NIH. NR 237 TC 64 Z9 66 U1 13 U2 77 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1053-8119 EI 1095-9572 J9 NEUROIMAGE JI Neuroimage PD JAN PY 2011 VL 54 SU 1 BP S106 EP S124 DI 10.1016/j.neuroimage.2010.01.105 PG 19 WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA 813ZF UT WOS:000294408600016 PM 20149882 ER PT J AU Lee, KYK Nyein, MK Moore, DF Joannopoulos, JD Socrate, S Imholt, T Radovitzky, R Johnson, SG AF Lee, Ka Yan Karen Nyein, Michelle K. Moore, David F. Joannopoulos, J. D. Socrate, Simona Imholt, Timothy Radovitzky, Raul Johnson, Steven G. TI Blast-induced electromagnetic fields in the brain from bone piezoelectricity SO NEUROIMAGE LA English DT Article ID TRANSCRANIAL MAGNETIC STIMULATION; INDUCED ELECTRICAL-POLARIZATION; SHOCK-INDUCED POLARIZATION; BIOLOGICAL TISSUES; GENERATION; POTENTIALS; MECHANISM; FREQUENCY; PLASTICS; STRESS AB In this paper, we show that bone piezoelectricity-a phenomenon in which bone polarizes electrically in response to an applied mechanical stress and produces a short-range electric field-may be a source of intense blast-induced electric fields in the brain, with magnitudes and timescales comparable to fields with known neurological effects. We compute the induced charge density in the skull from stress data on the skull from a finite-element full-head model simulation of a typical IED-scale blast wave incident on an unhelmeted human head as well as a human head protected by a kevlar helmet, and estimate the resulting electric fields in the brain in both cases to be on the order of 10 V/m in millisecond pulses. These fields are more than 10 times stronger than the IEEE safety guidelines for controlled environments (IEEE Standards Coordinating Committee 28, 2002) and comparable in strength and timescale to fields from repetitive Transcranial Magnetic Stimulation (rTMS) that are designed to induce neurological effects (Wagner et al., 2006a). They can be easily measured by RF antennas, and may provide the means to design a diagnostic tool that records a quantitative measure of the head's exposure to blast insult. (C) 2010 Elsevier Inc. All rights reserved. C1 [Lee, Ka Yan Karen] MIT, Dept Elect Engn, Cambridge, MA 02139 USA. [Nyein, Michelle K.; Radovitzky, Raul] MIT, Dept Aeronaut & Astronaut, Cambridge, MA 02139 USA. [Moore, David F.] Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20309 USA. [Joannopoulos, J. D.] MIT, Dept Phys, Cambridge, MA 02139 USA. [Socrate, Simona] MIT, Dept Mech Engn, Cambridge, MA 02139 USA. [Imholt, Timothy] Raytheon Co, Waltham, MA 02451 USA. [Johnson, Steven G.] MIT, Dept Math, Cambridge, MA 02139 USA. RP Lee, KYK (reprint author), MIT, Dept Elect Engn, Cambridge, MA 02139 USA. EM kylkaren@mit.edu RI Radovitzky, Raul/A-5353-2009 OI Radovitzky, Raul/0000-0001-6339-2708 FU Joint Improvised Explosive Device Defeat Organization (JIEDDO); Institute for Soldier Nanotechnologies (ISN) through the Army Research Office FX This work was supported in part by the Joint Improvised Explosive Device Defeat Organization (JIEDDO) and the Institute for Soldier Nanotechnologies (ISN) through the Army Research Office. We are grateful to Evan Reed for many helpful suggestions. NR 48 TC 8 Z9 8 U1 0 U2 14 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1053-8119 EI 1095-9572 J9 NEUROIMAGE JI Neuroimage PD JAN PY 2011 VL 54 SU 1 BP S30 EP S36 DI 10.1016/j.neuroimage.2010.05.042 PG 7 WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA 813ZF UT WOS:000294408600005 PM 20547228 ER PT B AU Wilhelm, T Andress, J AF Wilhelm, Thomas Andress, Jason BA Wilhelm, T Andress, J BF Wilhelm, T Andress, J TI The Historical Ninja SO NINJA HACKING: UNCONVENTIONAL PENETRATION TESTING TACTICS AND TECHNIQUES LA English DT Article; Book Chapter C1 [Wilhelm, Thomas] USA, Washington, DC 20310 USA. [Wilhelm, Thomas] Colorado Tech Univ, Colorado Springs, CO USA. RP Wilhelm, T (reprint author), USA, Washington, DC 20310 USA. NR 12 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-1-59749-589-9 PY 2011 BP 1 EP 22 DI 10.1016/B978-1-59749-588-2.00001-9 PG 22 WC Computer Science, Theory & Methods SC Computer Science GA BFC95 UT WOS:000319216300002 ER PT B AU Wilhelm, T Andress, J AF Wilhelm, Thomas Andress, Jason BA Wilhelm, T Andress, J BF Wilhelm, T Andress, J TI Ninja Hacking Unconventional Penetration Testing Tactics and Techniques Introduction SO NINJA HACKING: UNCONVENTIONAL PENETRATION TESTING TACTICS AND TECHNIQUES LA English DT Editorial Material; Book Chapter C1 [Wilhelm, Thomas] USA, Washington, DC 20310 USA. [Wilhelm, Thomas] Colorado Tech Univ, Colorado Springs, CO USA. RP Wilhelm, T (reprint author), USA, Washington, DC 20310 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-1-59749-589-9 PY 2011 BP XVII EP XXII DI 10.1016/B978-1-59749-588-2.00022-6 PG 6 WC Computer Science, Theory & Methods SC Computer Science GA BFC95 UT WOS:000319216300001 ER PT B AU Wilhelm, T Andress, J AF Wilhelm, Thomas Andress, Jason BA Wilhelm, T Andress, J BF Wilhelm, T Andress, J TI The Modern Ninja SO NINJA HACKING: UNCONVENTIONAL PENETRATION TESTING TACTICS AND TECHNIQUES LA English DT Article; Book Chapter C1 [Wilhelm, Thomas] USA, Washington, DC 20310 USA. [Wilhelm, Thomas] Colorado Tech Univ, Colorado Springs, CO USA. RP Wilhelm, T (reprint author), USA, Washington, DC 20310 USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-1-59749-589-9 PY 2011 BP 23 EP 36 DI 10.1016/B978-1-59749-588-2.00002-0 PG 14 WC Computer Science, Theory & Methods SC Computer Science GA BFC95 UT WOS:000319216300003 ER PT B AU Wilhelm, T Andress, J AF Wilhelm, Thomas Andress, Jason BA Wilhelm, T Andress, J BF Wilhelm, T Andress, J TI Strategies and Tactics SO NINJA HACKING: UNCONVENTIONAL PENETRATION TESTING TACTICS AND TECHNIQUES LA English DT Article; Book Chapter C1 [Wilhelm, Thomas] USA, Washington, DC 20310 USA. [Wilhelm, Thomas] Colorado Tech Univ, Colorado Springs, CO USA. RP Wilhelm, T (reprint author), USA, Washington, DC 20310 USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-1-59749-589-9 PY 2011 BP 37 EP 62 DI 10.1016/978-1-59749-588-2.00003-2 PG 26 WC Computer Science, Theory & Methods SC Computer Science GA BFC95 UT WOS:000319216300004 ER PT B AU Wilhelm, T Andress, J AF Wilhelm, Thomas Andress, Jason BA Wilhelm, T Andress, J BF Wilhelm, T Andress, J TI Exploitation of Current Events SO NINJA HACKING: UNCONVENTIONAL PENETRATION TESTING TACTICS AND TECHNIQUES LA English DT Article; Book Chapter C1 [Wilhelm, Thomas] USA, Washington, DC 20310 USA. [Wilhelm, Thomas] Colorado Tech Univ, Colorado Springs, CO USA. RP Wilhelm, T (reprint author), USA, Washington, DC 20310 USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-1-59749-589-9 PY 2011 BP 63 EP 73 DI 10.1016/B978-1-59749-588-2.00004-4 PG 11 WC Computer Science, Theory & Methods SC Computer Science GA BFC95 UT WOS:000319216300005 ER PT B AU Wilhelm, T Andress, J AF Wilhelm, Thomas Andress, Jason BA Wilhelm, T Andress, J BF Wilhelm, T Andress, J TI Disguise SO NINJA HACKING: UNCONVENTIONAL PENETRATION TESTING TACTICS AND TECHNIQUES LA English DT Article; Book Chapter C1 [Wilhelm, Thomas] USA, Washington, DC 20310 USA. [Wilhelm, Thomas] Colorado Tech Univ, Colorado Springs, CO USA. RP Wilhelm, T (reprint author), USA, Washington, DC 20310 USA. NR 12 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-1-59749-589-9 PY 2011 BP 75 EP 87 DI 10.1016/B978-1-59749-588-2.00005-6 PG 13 WC Computer Science, Theory & Methods SC Computer Science GA BFC95 UT WOS:000319216300006 ER PT B AU Wilhelm, T Andress, J AF Wilhelm, Thomas Andress, Jason BA Wilhelm, T Andress, J BF Wilhelm, T Andress, J TI Impersonation SO NINJA HACKING: UNCONVENTIONAL PENETRATION TESTING TACTICS AND TECHNIQUES LA English DT Article; Book Chapter C1 [Wilhelm, Thomas] USA, Washington, DC 20310 USA. [Wilhelm, Thomas] Colorado Tech Univ, Colorado Springs, CO USA. RP Wilhelm, T (reprint author), USA, Washington, DC 20310 USA. NR 17 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-1-59749-589-9 PY 2011 BP 89 EP 101 DI 10.1016/B978-1-59749-588-2.00006-8 PG 13 WC Computer Science, Theory & Methods SC Computer Science GA BFC95 UT WOS:000319216300007 ER PT B AU Wilhelm, T Andress, J AF Wilhelm, Thomas Andress, Jason BA Wilhelm, T Andress, J BF Wilhelm, T Andress, J TI Infiltration SO NINJA HACKING: UNCONVENTIONAL PENETRATION TESTING TACTICS AND TECHNIQUES LA English DT Article; Book Chapter C1 [Wilhelm, Thomas] USA, Washington, DC 20310 USA. [Wilhelm, Thomas] Colorado Tech Univ, Colorado Springs, CO USA. RP Wilhelm, T (reprint author), USA, Washington, DC 20310 USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-1-59749-589-9 PY 2011 BP 103 EP 118 DI 10.1016/B978-1-59749-588-2.00007-X PG 16 WC Computer Science, Theory & Methods SC Computer Science GA BFC95 UT WOS:000319216300008 ER PT B AU Wilhelm, T Andress, J AF Wilhelm, Thomas Andress, Jason BA Wilhelm, T Andress, J BF Wilhelm, T Andress, J TI Use of Timing to Enter an Area SO NINJA HACKING: UNCONVENTIONAL PENETRATION TESTING TACTICS AND TECHNIQUES LA English DT Article; Book Chapter C1 [Wilhelm, Thomas] USA, Washington, DC 20310 USA. [Wilhelm, Thomas] Colorado Tech Univ, Colorado Springs, CO USA. RP Wilhelm, T (reprint author), USA, Washington, DC 20310 USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-1-59749-589-9 PY 2011 BP 119 EP 134 DI 10.1016/B978-1-59749-588-2.00008-1 PG 16 WC Computer Science, Theory & Methods SC Computer Science GA BFC95 UT WOS:000319216300009 ER PT B AU Wilhelm, T Andress, J AF Wilhelm, Thomas Andress, Jason BA Wilhelm, T Andress, J BF Wilhelm, T Andress, J TI Discovering Weak Points in Area Defenses SO NINJA HACKING: UNCONVENTIONAL PENETRATION TESTING TACTICS AND TECHNIQUES LA English DT Article; Book Chapter C1 [Wilhelm, Thomas] USA, Washington, DC 20310 USA. [Wilhelm, Thomas] Colorado Tech Univ, Colorado Springs, CO USA. RP Wilhelm, T (reprint author), USA, Washington, DC 20310 USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-1-59749-589-9 PY 2011 BP 135 EP 149 DI 10.1016/B978-1-59749-588-2.00009-3 PG 15 WC Computer Science, Theory & Methods SC Computer Science GA BFC95 UT WOS:000319216300010 ER PT B AU Wilhelm, T Andress, J AF Wilhelm, Thomas Andress, Jason BA Wilhelm, T Andress, J BF Wilhelm, T Andress, J TI Psychological Weaknesses SO NINJA HACKING: UNCONVENTIONAL PENETRATION TESTING TACTICS AND TECHNIQUES LA English DT Article; Book Chapter C1 [Wilhelm, Thomas] USA, Washington, DC 20310 USA. [Wilhelm, Thomas] Colorado Tech Univ, Colorado Springs, CO USA. RP Wilhelm, T (reprint author), USA, Washington, DC 20310 USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-1-59749-589-9 PY 2011 BP 151 EP 165 DI 10.1016/B978-1-59749-588-2.00010-X PG 15 WC Computer Science, Theory & Methods SC Computer Science GA BFC95 UT WOS:000319216300011 ER PT B AU Wilhelm, T Andress, J AF Wilhelm, Thomas Andress, Jason BA Wilhelm, T Andress, J BF Wilhelm, T Andress, J TI Distraction SO NINJA HACKING: UNCONVENTIONAL PENETRATION TESTING TACTICS AND TECHNIQUES LA English DT Article; Book Chapter C1 [Wilhelm, Thomas] USA, Washington, DC 20310 USA. [Wilhelm, Thomas] Colorado Tech Univ, Colorado Springs, CO USA. RP Wilhelm, T (reprint author), USA, Washington, DC 20310 USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-1-59749-589-9 PY 2011 BP 167 EP 181 DI 10.1016/B978-1-59749-588-2.00011-1 PG 15 WC Computer Science, Theory & Methods SC Computer Science GA BFC95 UT WOS:000319216300012 ER PT B AU Wilhelm, T Andress, J AF Wilhelm, Thomas Andress, Jason BA Wilhelm, T Andress, J BF Wilhelm, T Andress, J TI Concealment Devices SO NINJA HACKING: UNCONVENTIONAL PENETRATION TESTING TACTICS AND TECHNIQUES LA English DT Article; Book Chapter C1 [Wilhelm, Thomas] USA, Washington, DC 20310 USA. [Wilhelm, Thomas] Colorado Tech Univ, Colorado Springs, CO USA. RP Wilhelm, T (reprint author), USA, Washington, DC 20310 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-1-59749-589-9 PY 2011 BP 183 EP 205 DI 10.1016/B978-1-59749-588-2.00012-3 PG 23 WC Computer Science, Theory & Methods SC Computer Science GA BFC95 UT WOS:000319216300013 ER PT B AU Wilhelm, T Andress, J AF Wilhelm, Thomas Andress, Jason BA Wilhelm, T Andress, J BF Wilhelm, T Andress, J TI Covert Listening Devices SO NINJA HACKING: UNCONVENTIONAL PENETRATION TESTING TACTICS AND TECHNIQUES LA English DT Article; Book Chapter C1 [Wilhelm, Thomas] USA, Washington, DC 20310 USA. [Wilhelm, Thomas] Colorado Tech Univ, Colorado Springs, CO USA. RP Wilhelm, T (reprint author), USA, Washington, DC 20310 USA. NR 12 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-1-59749-589-9 PY 2011 BP 207 EP 226 DI 10.1016/B978-1-59749-588-2.00013-5 PG 20 WC Computer Science, Theory & Methods SC Computer Science GA BFC95 UT WOS:000319216300014 ER PT B AU Wilhelm, T Andress, J AF Wilhelm, Thomas Andress, Jason BA Wilhelm, T Andress, J BF Wilhelm, T Andress, J TI Intelligence SO NINJA HACKING: UNCONVENTIONAL PENETRATION TESTING TACTICS AND TECHNIQUES LA English DT Article; Book Chapter C1 [Wilhelm, Thomas] USA, Washington, DC 20310 USA. [Wilhelm, Thomas] Colorado Tech Univ, Colorado Springs, CO USA. RP Wilhelm, T (reprint author), USA, Washington, DC 20310 USA. NR 18 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-1-59749-589-9 PY 2011 BP 227 EP 245 DI 10.1016/B978-1-59749-588-2.00014-7 PG 19 WC Computer Science, Theory & Methods SC Computer Science GA BFC95 UT WOS:000319216300015 ER PT B AU Wilhelm, T Andress, J AF Wilhelm, Thomas Andress, Jason BA Wilhelm, T Andress, J BF Wilhelm, T Andress, J TI Surveillance SO NINJA HACKING: UNCONVENTIONAL PENETRATION TESTING TACTICS AND TECHNIQUES LA English DT Article; Book Chapter C1 [Wilhelm, Thomas] USA, Washington, DC 20310 USA. [Wilhelm, Thomas] Colorado Tech Univ, Colorado Springs, CO USA. RP Wilhelm, T (reprint author), USA, Washington, DC 20310 USA. NR 15 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-1-59749-589-9 PY 2011 BP 247 EP 266 DI 10.1016/B978-1-59749-588-2.00015-9 PG 20 WC Computer Science, Theory & Methods SC Computer Science GA BFC95 UT WOS:000319216300016 ER PT B AU Wilhelm, T Andress, J AF Wilhelm, Thomas Andress, Jason BA Wilhelm, T Andress, J BF Wilhelm, T Andress, J TI Sabotage SO NINJA HACKING: UNCONVENTIONAL PENETRATION TESTING TACTICS AND TECHNIQUES LA English DT Article; Book Chapter C1 [Wilhelm, Thomas] USA, Washington, DC 20310 USA. [Wilhelm, Thomas] Colorado Tech Univ, Colorado Springs, CO USA. RP Wilhelm, T (reprint author), USA, Washington, DC 20310 USA. NR 13 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-1-59749-589-9 PY 2011 BP 267 EP 284 DI 10.1016/B978-1-59749-588-2.00016-0 PG 18 WC Computer Science, Theory & Methods SC Computer Science GA BFC95 UT WOS:000319216300017 ER PT B AU Wilhelm, T Andress, J AF Wilhelm, Thomas Andress, Jason BA Wilhelm, T Andress, J BF Wilhelm, T Andress, J TI Hiding and Silent Movement SO NINJA HACKING: UNCONVENTIONAL PENETRATION TESTING TACTICS AND TECHNIQUES LA English DT Article; Book Chapter C1 [Wilhelm, Thomas] USA, Washington, DC 20310 USA. [Wilhelm, Thomas] Colorado Tech Univ, Colorado Springs, CO USA. RP Wilhelm, T (reprint author), USA, Washington, DC 20310 USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-1-59749-589-9 PY 2011 BP 285 EP 301 DI 10.1016/B978-1-59749-588-2.00017-2 PG 17 WC Computer Science, Theory & Methods SC Computer Science GA BFC95 UT WOS:000319216300018 ER PT S AU Clayton, JD AF Clayton, John D. TI Nonlinear Mechanics of Crystals SO NONLINEAR MECHANICS OF CRYSTALS SE Solid Mechanics and its Applications LA English DT Article; Book ID FINITE-DEFORMATION PLASTICITY; ORDER ELASTIC-CONSTANTS; ENERGY-MOMENTUM TENSOR; ANGLE GRAIN-BOUNDARIES; CONTINUOUSLY DISTRIBUTED DISLOCATIONS; CRYSTALLOGRAPHIC TEXTURE EVOLUTION; VERSETZUNGEN UND EIGENSPANNUNGEN; DISCLINATION REACTION-KINETICS; STRAIN GRADIENT ELASTICITY; SHOCK-INDUCED POLARIZATION C1 USA, Res Lab, RDRL WMP B, Aberdeen Proving Ground, MD 21005 USA. RP Clayton, JD (reprint author), USA, Res Lab, RDRL WMP B, Bldg 390,Room 212, Aberdeen Proving Ground, MD 21005 USA. EM jdclayt@comcast.net NR 730 TC 6 Z9 6 U1 2 U2 5 PU SPRINGER PI DORDRECHT PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0925-0042 BN 978-94-007-0349-0 J9 SOLID MECH APPL PY 2011 VL 177 BP 1 EP 690 DI 10.1007/978-94-007-0350-6_1 PG 690 WC Crystallography; Mechanics SC Crystallography; Mechanics GA BSR90 UT WOS:000285563200001 ER PT J AU Sarnecky, MT AF Sarnecky, Mary T. TI Officer, Nurse, Woman: The Army Nurse Corps in the Vietnam War SO NURSING HISTORY REVIEW LA English DT Book Review C1 [Sarnecky, Mary T.] USA, Off Surg Gen, Carlsbad, CA 92009 USA. RP Sarnecky, MT (reprint author), USA, Off Surg Gen, 2856 Cacatua St, Carlsbad, CA 92009 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PUBLISHING CO PI NEW YORK PA 11 WEST 42ND STREET, NEW YORK, NY 10036 USA SN 1062-8061 J9 NURS HIST REV JI Nurs. Hist. Rev. PY 2011 VL 19 BP 239 EP 240 PG 2 WC History & Philosophy Of Science; History Of Social Sciences; Nursing SC History & Philosophy of Science; Social Sciences - Other Topics; Nursing GA 794OH UT WOS:000292909200041 ER PT J AU Stratis-Cullum, DN Kogot, JM Sarkes, DA Val-Addo, I Pellegrino, PM AF Stratis-Cullum, Dimitra N. Kogot, Joshua M. Sarkes, Deborah A. Val-Addo, Irene Pellegrino, Paul M. BE Pramatarova, L TI Bacterial Display Peptides for Use in Biosensing Applications SO ON BIOMIMETICS LA English DT Article; Book Chapter ID PROTEIN-BINDING PEPTIDES; SURFACE DISPLAY; CANCER-CELLS; LIBRARIES; ENRICHMENT; SELECT C1 [Stratis-Cullum, Dimitra N.; Kogot, Joshua M.; Sarkes, Deborah A.; Val-Addo, Irene; Pellegrino, Paul M.] US Army Res Lab, Adelphi, MD 20783 USA. RP Stratis-Cullum, DN (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. NR 21 TC 4 Z9 4 U1 0 U2 0 PU INTECH EUROPE PI RIJEKA PA JANEZA TRDINE9, RIJEKA, 51000, CROATIA BN 978-953-307-271-5 PY 2011 BP 629 EP 642 D2 10.5772/774 PG 14 WC Biotechnology & Applied Microbiology; Engineering, Biomedical; Materials Science, Biomaterials SC Biotechnology & Applied Microbiology; Engineering; Materials Science GA BE9UK UT WOS:000378207100031 ER PT J AU DeLeon, PH Folen, RA AF DeLeon, Patrick H. Folen, Raymond A. BE Kraus, R Stricker, G Speyer, C TI Unprecedented Change is Upon Us Foreword SO ONLINE COUNSELING: A HANDBOOK FOR MENTAL HEALTH PROFESSIONALS, 2ND EDITION SE Practical Resources for the Mental Health Professional LA English DT Editorial Material; Book Chapter C1 [DeLeon, Patrick H.] Amer Psychol Assoc, Washington, DC USA. [Folen, Raymond A.] Tripler Army Med Ctr, Honolulu, HI USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER ACADEMIC PRESS INC PI SAN DIEGO PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA BN 978-0-12-378597-8 J9 PRACT RESOUR MENT PY 2011 BP IX EP XVI DI 10.1016/B978-0-12-378596-1.00018-6 PG 8 WC Psychology, Clinical SC Psychology GA BEM85 UT WOS:000317403900001 ER PT J AU Banks, HD AF Banks, Harold D. TI Substituent effects on the rate of formation of azomethine ylides. A computational investigation SO ORGANIC & BIOMOLECULAR CHEMISTRY LA English DT Article ID FREE CLICK CHEMISTRY; COPPER-FREE CLICK; PLESSET PERTURBATION-THEORY; AZIDE-ALKYNE CYCLOADDITION; 1,3-DIPOLAR CYCLOADDITIONS; STEREOSELECTIVE-SYNTHESIS; EFFICIENT SYNTHESIS; TERMINAL ALKYNES; SOLVATION MODELS; AZIRIDINES AB The effect of substituents on the rate of conrotatory thermal cleavage of aziridine has been studied at the MP2(Full)/6-311++G(d,p)//MP2(Full)/6-31+G(d) level and also using SCS-MP2 methodology. While the parent compound has a high free energy of activation (194.6 kJ mol(-1)), this value could be drastically lowered by substituent effects. Anionic species were found to be particularly effective in increasing the calculated reaction rate. The potential utility of this approach in 1,3-dipolar cycloaddition is discussed. C1 USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Banks, HD (reprint author), USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM harold.banks@us.army.mil NR 123 TC 0 Z9 0 U1 1 U2 9 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1477-0520 J9 ORG BIOMOL CHEM JI Org. Biomol. Chem. PY 2011 VL 9 IS 18 BP 6335 EP 6342 DI 10.1039/c1ob05588g PG 8 WC Chemistry, Organic SC Chemistry GA 812BY UT WOS:000294263900022 PM 21785788 ER PT J AU Barnes, CM AF Barnes, Christopher M. TI I'll sleep when I'm dead: Managing those too busy to sleep SO ORGANIZATIONAL DYNAMICS LA English DT Article ID DECISION-MAKING; DEPRIVATION; TIME C1 US Mil Acad, Ctr Army Profess & Eth, West Point, NY 10996 USA. RP Barnes, CM (reprint author), US Mil Acad, Ctr Army Profess & Eth, Bldg 621, West Point, NY 10996 USA. EM christopher.montgomery.barnes@gmail.com RI Barnes, Christopher/O-4814-2014 OI Barnes, Christopher/0000-0003-2520-6200 NR 7 TC 19 Z9 19 U1 3 U2 11 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-2616 J9 ORGAN DYN JI Organ. Dyn. PD JAN-MAR PY 2011 VL 40 IS 1 BP 18 EP + DI 10.1016/j.orgdyn.2010.10.001 PG 10 WC Business; Psychology, Applied; Management SC Business & Economics; Psychology GA 722MN UT WOS:000287436500003 ER PT J AU Maani, CV Hoffman, HG Fowler, M Maiers, AJ Gaylord, KM DeSocio, PA AF Maani, Christopher V. Hoffman, Hunter G. Fowler, Marcie Maiers, Alan J. Gaylord, Kathryn M. DeSocio, Peter A. TI Combining Ketamine and Virtual Reality Pain Control During Severe Burn Wound Care: One Military and One Civilian Patient SO PAIN MEDICINE LA English DT Article DE Analgesia; Burn Pain; Wound Care; Distraction; Virtual Reality ID PHYSICAL-THERAPY; THERMAL PAIN; DISTRACTION; ANALGESIA; MAGNITUDE AB Background. US soldiers injured in Iraq, and civilian burn trauma patients are treated at the US Army Institute of Surgical Research. Burn patients experience extrem pain during wound care, and they typically receive opioid analgesics and anxiolytics for debridement. Virtual Reality (VR) has been applied as an adjunct to opioid analgesics for procedural pain. We describe the first use of ketamine combined with immersive VR to reduce excessive pain during wound care. Case Report. A 21-year-old male US Army soldier stationed in Iraq, and a 41-year-old civilian male sustained a 13% and 50% total body surface area (TBSA) burn, respectively. Each patient received 40 mg ketamine intraveneous (IV) for wound care. Using a within-subject design, nurses conducted half of a painful segment of wound care treatments with no VR and the other half with immersive VR. Graphic pain rating scores for each of the two treatment conditions served as the dependent variables. Results. Compared to ketamine + no VR, both patients reported less pain during ketamine + VR for all three pain ratings. Both patients rated wound care during no VR as "no fun at all", but those same patients rated wound care during virtual reality as either "pretty fun" or "extremely fun", and rated nausea as either "mild" or "none". Conclusions. Results from these first two cases suggest that a moderate dose of ketamine combined with immersive virtual reality distraction may be an effective multimodal analgesic regimen for reducing acute procedural pain during severe burn wound cleanings. C1 [DeSocio, Peter A.] Ohio State Univ, Med Ctr, Dept Anesthesiol, Columbus, OH 43210 USA. [Hoffman, Hunter G.] Univ Washington, Dept Mech Engn, Seattle, WA 98195 USA. [Hoffman, Hunter G.] Univ Washington, Human Interface Technol Lab, Seattle, WA 98195 USA. [Maani, Christopher V.; Fowler, Marcie; Maiers, Alan J.; Gaylord, Kathryn M.] USA, Army Inst Surg Res, Brooke Army Med Ctr, San Antonio, TX USA. RP Maani, CV (reprint author), USA, Dept Anesthesiol, Inst Surg Res, San Antonio, TX 78234 USA. EM Christopher.Maani@us.army.mil RI DeSocio, Peter/E-2970-2011 FU US Army Institute of Surgical Research; NIH [1R01AR054115-01A1, R01GM042725-17A1]; Scan Design Foundation FX This study was funded by US Army Institute of Surgical Research. Hunter Hoffman's time was funded with help from the following NIH grants to Drs. Patterson and Sharar at the UW: NIH 1R01AR054115-01A1, R01GM042725-17A1, the Scan Design Foundation by Inger and Jens Bruun, and private donations from Ross Chambers. Thanks to Admiral Mullens, General Chiarelli, COL Sutherland, COL Friedl, Dr. Belard, Luke Knittig, and to musician Paul Simon for their encouragement. NR 33 TC 5 Z9 6 U1 2 U2 8 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1526-2375 J9 PAIN MED JI Pain Med. PY 2011 VL 12 IS 4 BP 673 EP 678 DI 10.1111/j.1526-4637.2011.01091.x PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 751OX UT WOS:000289628500016 PM 21481162 ER PT J AU Dragovich, A Trainer, RJ AF Dragovich, Anthony Trainer, Robert J. TI A Report of 3 Soldiers Returned to Full Duty after Lumbar Radiofrequency Facet Denervation in a Theater of War SO PAIN MEDICINE LA English DT Article DE Zygapophysial; Nerve Ablation; Soldiers; Combat; Axial; Low Back Pain ID LOW-BACK-PAIN; DOUBLE-BLIND; JOINT DENERVATION; TRIAL; EFFICACY; NEUROTOMY; SCIATICA AB Objective. To provide the advanced interventional procedure of zygapophysial joint neurotomy to soldiers meeting the diagnostic criteria in a combat environment and thus reduce medical evacuations of soldiers from a theater of war. Design. Retrospective chart review was performed on three consecutive soldiers who received neuroablation of the lumbar ZP joint. Patients received single MBB with 1 cc of 1% lidocaine at the b/l L3-L5 levels considered diagnostic if > 50% analgesia was achieved concordant with duration of anesthetic. Setting. All procedures were co-performed by the two authors at the Ibn Sina hospital in Baghdad, Iraq over a 3-month period. Patients. Three consecutive patients with > 50% pain relief from diagnostic medial branch blocks were treated with radiofrequency ablation of the bilateral L3-L4 medial branch nerves and L5 posterior primary ramus. Interventions. Sensory test stimulation at 50 Hz and motor stimulation at 2 Hz were performed at each level. The nerves were then lesioned at 80 degrees Centigrade for 90 seconds after injection of lidocaine and methylprednisolone. Outcome Measures. Procedure was considered successful if patients were able to wear body armour without significant discomfort (at least 1 hour/day). Results and Conclusions. Medical evacuation from Iraq was prevented and all soldiers returned to rigorous combat duties including the wearing of body armour daily. We believe to be the first to report on the use of RF nerve ablation in a war time setting and with this functional outcome. C1 [Dragovich, Anthony] Beth Israel Deaconness Med Ctr, Dept Pain Med, Boston, MA 02445 USA. [Trainer, Robert J.] Walter Reed Army Med Ctr, Dept Anesthesiol, Washington, DC 20307 USA. RP Trainer, RJ (reprint author), Beth Israel Deaconness Med Ctr, Dept Pain Med, 1 Brookline Ave, Boston, MA 02445 USA. EM rob.trainer@gmail.com NR 15 TC 2 Z9 2 U1 0 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1526-2375 J9 PAIN MED JI Pain Med. PY 2011 VL 12 IS 4 BP 679 EP 681 DI 10.1111/j.1526-4637.2010.01041.x PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 751OX UT WOS:000289628500017 PM 21223502 ER PT J AU Buckenmaier, CC AF Buckenmaier, Chester C., III TI A Tradition of Traditional Medicine SO PAIN MEDICINE LA English DT Editorial Material C1 Walter Reed Army Med Ctr, Def & Vet Ctr Integrat Pain Management, Washington, DC 20307 USA. RP Buckenmaier, CC (reprint author), Walter Reed Army Med Ctr, Def & Vet Ctr Integrat Pain Management, Washington, DC 20307 USA. OI Buckenmaier III, Chester/0000-0003-3623-5525 NR 2 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1526-2375 J9 PAIN MED JI Pain Med. PY 2011 VL 12 IS 7 BP 1005 EP 1007 DI 10.1111/j.1526-4637.2011.01154.x PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 791WA UT WOS:000292697100004 PM 21668744 ER PT J AU Grathwohl, KW AF Grathwohl, Kurt W. TI Does Ketamine Improve Postoperative Analgesia? More Questions Than Answers SO PAIN MEDICINE LA English DT Editorial Material C1 [Grathwohl, Kurt W.] Brooke Army Med Ctr, Surg Trauma Intens Care Unit, Ft Sam Houston, TX 78234 USA. [Grathwohl, Kurt W.] SAUSHEC, San Antonio, TX USA. [Grathwohl, Kurt W.] US Army Surg Gen, Falls Church, VA USA. RP Grathwohl, KW (reprint author), Brooke Army Med Ctr, Surg Trauma Intens Care Unit, Ft Sam Houston, TX 78234 USA. NR 5 TC 3 Z9 3 U1 1 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1526-2375 J9 PAIN MED JI Pain Med. PY 2011 VL 12 IS 8 BP 1135 EP 1136 DI 10.1111/j.1526-4637.2011.01199.x PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 808SC UT WOS:000293997700001 PM 21848837 ER PT J AU Williams, KA Gonzalez-Fernandez, M Hamzehzadeh, S Wilkinson, I Erdek, MA Plunkett, A Griffith, S Crooks, M Larkin, T Cohen, SP AF Williams, Kayode A. Gonzalez-Fernandez, Marlis Hamzehzadeh, Sayeh Wilkinson, Indy Erdek, Michael A. Plunkett, Anthony Griffith, Scott Crooks, Matthew Larkin, Thomas Cohen, Steven P. TI A Multi-Center Analysis Evaluating Factors Associated with Spinal Cord Stimulation Outcome in Chronic Pain Patients SO PAIN MEDICINE LA English DT Article DE Outcome Assessment; Chronic Pain; Neuropathy; Pain Management ID LOW-BACK-PAIN; NEUROPATHIC PAIN; RADIOFREQUENCY DENERVATION; CLINICAL-TRIALS; RISK-FACTORS; LEEDS ASSESSMENT; JOINT PAIN; MECHANISMS; SUCCESS; EXPERIENCE AB Background. In addition to its conventional use as a treatment for refractory neuropathic extremity pain, spinal cord stimulation (SCS) has recently emerged as a possible treatment for visceral and arthritic pain. But concurrent with the expansion of possible conditions amenable to SCS, other studies have questioned the long-term efficacy of SCS for traditional indications. These disparate findings argue strongly for the refinement of selection criteria. The purpose of this study is to identify correlates of outcome for SCS. Methods. Data were retrospectively collected on 244 patients who underwent a SCS trial at two academic medical centers. Success was predefined as >= 50% pain relief sustained for >= 6 months. Variables analyzed for their association with outcome included demographics, location of pain, diagnosis, presence of coexisting diseases, pain descriptors, opioid and adjuvant medication use, duration and pain relief during trial, and complications. Results. The presence of allodynia and/or hyperalgesia correlated with both a positive SCS trial (P = 0.01) and long-term implantation outcome (P = 0.05). History of substance abuse was associated with a negative permanent SCS outcome (P = 0.05) but bore no relationship to trial results. The variable most strongly associated with an SCS outcome was experiencing <50% pain relief during the trial, which strongly presaged a negative result (P < 0.001). Conclusions. Although weak associations with outcome were noted for several clinical variables, none was strongly associated with trial and permanent implantation results. The strongest predictor of a negative SCS outcome was obtaining <50% pain relief during the trial period. C1 [Williams, Kayode A.; Hamzehzadeh, Sayeh; Erdek, Michael A.; Cohen, Steven P.] Johns Hopkins Sch Med, Dept Anesthesiol, Pain Med Div, Baltimore, MD 21287 USA. [Gonzalez-Fernandez, Marlis] Johns Hopkins Sch Med, Dept Phys Med & Rehabil, Baltimore, MD 21287 USA. [Wilkinson, Indy; Plunkett, Anthony; Griffith, Scott; Larkin, Thomas; Cohen, Steven P.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Wilkinson, Indy; Plunkett, Anthony; Griffith, Scott; Larkin, Thomas; Cohen, Steven P.] Walter Reed Army Med Ctr, Dept Anesthesiol, Washington, DC 20307 USA. [Crooks, Matthew] Univ Calif Los Angeles, Dept Anesthesiol, Los Angeles, CA 90024 USA. RP Williams, KA (reprint author), Johns Hopkins Sch Med, Dept Anesthesiol & Crit Care Med, 600 N Wolfe St,Osler 292, Baltimore, MD 21287 USA. EM kwilli64@jmi.edu OI Gonzalez-Fernandez, Marlis/0000-0002-1576-3452 NR 55 TC 10 Z9 10 U1 1 U2 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1526-2375 J9 PAIN MED JI Pain Med. PY 2011 VL 12 IS 8 BP 1142 EP 1153 DI 10.1111/j.1526-4637.2011.01184.x PG 12 WC Medicine, General & Internal SC General & Internal Medicine GA 808SC UT WOS:000293997700004 PM 21749636 ER PT J AU Lai, TT Jaeger, L Jones, BL Kaderbek, EW Malchow, RJ AF Lai, Tristan T. Jaeger, Lisa Jones, Benjamin L. Kaderbek, Eric W. Malchow, Randall J. TI Continuous Peripheral Nerve Block Catheter Infections in Combat-related Injuries: A Case Report of Five Soldiers from Operation Enduring Freedom/Operation Iraqi Freedom SO PAIN MEDICINE LA English DT Article DE Polytrauma; Postoperative Pain; Continuous Peripheral Nerve Block; Nerve Catheter Duration; Infection; Antibiotics ID CONTINUOUS INTERSCALENE BLOCK; REGIONAL ANESTHESIA; POSTOPERATIVE ANALGESIA; COMPLICATIONS; SURGERY; PAIN; REHABILITATION; ANGIOPLASTY; MULTICENTER; ABSCESS AB Design. Case series. Setting. Military medical facility providing acute care for soldiers injured while fighting in the war in Iraq and Afghanistan. Objective. To report a series of infections related to use of continuous peripheral nerve catheters for postoperative pain control in the military polytraumatic setting. The analysis of the above infections includes similarities and differences in infection patterns and attempts to clarify possible risk factors for such infections to include duration of catheter placement, type of catheter, preprocedural antibiotics, and tunnel vs nontunneled catheters. The goal of this analysis is to assist in the development of protocols that may prevent future catheter infections. Methods. Clinical data were obtained from five previously healthy male soldiers receiving acute care at Brooke Army Medical Center using continuous peripheral nerve catheters for postoperative pain for multiple and frequent procedures. Results. In a total of six catheter infections, two were noted to have superficial skin infections while four were shown to have deep tissue involvement confirmed by imaging studies. All patients were started on initial or additional antibiotics after catheter removal. Three catheter infections, all with stimulating catheters, required surgical irrigation and debridement in the operating room. Conclusions. Continuous peripheral nerve catheters are not without complications and risks including infection. Duration of catheter use was the most significant factor with the development of a catheter-related infection in our series. This series also highlights how stimulating and nonstimulating catheter infections may present differently, as stimulating catheters may have a greater tendency to present as deep space infections with minimal superficial findings. C1 [Lai, Tristan T.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Malchow, Randall J.] Vanderbilt Univ, Med Ctr, Nashville, TN USA. [Jones, Benjamin L.] Brooke Army Med Ctr, San Antonio, TX USA. [Kaderbek, Eric W.] Eglin AFB Med Ctr, Niceville, FL USA. RP Malchow, RJ (reprint author), Vanderbilt Univ Sch Med, Vanderbilt Clin 4648, 1301 Med Ctr Dr, Nashville, TN 37232 USA. EM randall.malchow@vanderbilt.edu NR 22 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1526-2375 J9 PAIN MED JI Pain Med. PY 2011 VL 12 IS 11 BP 1676 EP 1681 DI 10.1111/j.1526-4637.2011.01251.x PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 854PO UT WOS:000297506900016 PM 21992571 ER PT S AU Hanlon, TM Wright, WC Henderson, JP Hendricks, MD AF Hanlon, Thomas M. Wright, William C. Henderson, Joseph P. Hendricks, Michael D. BE Lee, J TI TEACHING MILITARY GEOGRAPHY THROUGH GIS: RE-EVALUATING THE DEFENSE OF REVOLUTIONARY WAR ERA WEST POINT SO PAPERS OF THE APPLIED GEOGRAPHY CONFERENCES, VOL 34 SE PAPERS AND PROCEEDINGS OF APPLIED GEOGRAPHY CONFERENCES LA English DT Proceedings Paper CT 34th Annual Applied Geography Conference CY OCT 19-22, 2011 CL Univ Redlands, Redlands, CA SP Kent State Univ, Univ Redlands, Texas Christian Univ, Texas State Univ San Marcos, Binghamton Univ, George Mason Univ, Florida Atlant Univ HO Univ Redlands C1 [Hanlon, Thomas M.; Wright, William C.; Henderson, Joseph P.; Hendricks, Michael D.] US Mil Acad, 745 Brewerton Rd, West Point, NY 10996 USA. RP Hanlon, TM (reprint author), US Mil Acad, 745 Brewerton Rd, West Point, NY 10996 USA. EM thomas.m.hanlon@usma.edu NR 9 TC 0 Z9 0 U1 0 U2 0 PU SUNY BINGHAMTON DEPT GEOGRAPHY PI BINGHAMTON PA BINGHAMTON, NY 13901 USA SN 0747-5160 J9 PAP P APPL PY 2011 VL 34 BP 112 EP 118 PG 7 WC Geography; Geography, Physical SC Geography; Physical Geography GA BG8RI UT WOS:000392673800013 ER PT J AU Ramadurai, D Orosz, WC Nelson, A Garland, JW Stephenson, LD Kumar, A AF Ramadurai, D. Orosz, W. C. Nelson, A. Garland, J. W. Stephenson, L. D. Kumar, Ashok TI Fast Photolytic Release of Nano-Encapsulated Biocides for Neutralizing Bacteria SO PARTICULATE SCIENCE AND TECHNOLOGY LA English DT Article DE bacteria; liposomes; neutralization; phospholipids; photolytic-release ID SINGLET MOLECULAR-OXYGEN; LIPOSOMES; MEROCYANINE-540 AB A fast-triggered photolytic technology based on the on-demand release of biocides encapsulated within phospholipid nanoparticles has been developed for the neutralization of biological contaminants such as bacteria. Fast-triggered release occurs when light sensitive molecules (photosensitizers) embedded within phospholipid particles are triggered by an external light stimulus. The photo-induced oxidation due to the stimulus causes the lipid chains to break and rapidly release their contents. When the phospholipid carriers are loaded with strong biocides, the fast-triggered release can result in the neutralization of biological contaminants in a controlled environment. It was observed that a 98% release of biocides was achieved in 12min and 68% release achieved in 2min through photo-induced oxidation. This method of release of biocides potentially can offer a technology for rapid decontamination inside heating, ventilation and air conditioning (HVAC) systems and surfaces such as walls, windows, etc. Moreover, biocide loaded phospholipid particles could be released as aerosols for neutralizing airborne bacteria and other biological contaminants. The appropriate choice of biocides can enable potential use in first-responder type situations and the automatic remote neutralization following bacterial contamination of air ducts or surfaces. C1 [Ramadurai, D.] EPIR Technol Inc, Biosensors, Bolingbrook, IL 60440 USA. [Nelson, A.; Stephenson, L. D.; Kumar, Ashok] USA, Corps Engn, Engn Res & Dev Ctr, Champaign, IL USA. RP Ramadurai, D (reprint author), EPIR Technol Inc, Biosensors, 590 Territorial Dr, Bolingbrook, IL 60440 USA. EM rdinakar@epir.com FU U.S. Army Department of Defense (DoD) [W9132 T-08-C-0009] FX This work was supported with the funds provided by the U.S. Army Department of Defense (DoD) under the SBIR program contract no. W9132 T-08-C-0009. NR 14 TC 1 Z9 1 U1 0 U2 4 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0272-6351 J9 PARTICUL SCI TECHNOL JI Part. Sci. Technol. PY 2011 VL 29 IS 3 BP 252 EP 259 AR PII 936744620 DI 10.1080/02726351.2010.494709 PG 8 WC Engineering, Chemical SC Engineering GA 753RY UT WOS:000289798500004 ER PT B AU Neufeld, JA Monasterio, ED Taylor, LA Riddick-Grisham, S Livingston, LA AF Neufeld, Jacob A. Monasterio, Eugenio D. Taylor, Laura A. Riddick-Grisham, Susan Livingston, Lee A. BE RiddickGrisham, S Deming, LM TI Life Care Planning for Children with Neurodevelopmental Disabilities SO PEDIATRIC LIFE CARE PLANNING AND CASE MANAGEMENT, 2ND EDITION LA English DT Article; Book Chapter ID SELECTIVE DORSAL RHIZOTOMY; NEURAL-TUBE DEFECTS; SPINA-BIFIDA; CEREBRAL-PALSY; FOLIC-ACID; DEVELOPMENTAL-DISABILITIES; PHYSICAL-DISABILITIES; BOTULINUM TOXIN; YOUNG INFANTS; SELF-CONCEPT C1 [Neufeld, Jacob A.] Childrens Hosp & Res Ctr Oakland, Div Pediat Rehabil, Oakland, CA USA. [Monasterio, Eugenio D.] Childrens Hosp, Richmond, VA USA. [Taylor, Laura A.] Virginia Commonwealth Univ, Dept Phys Med & Rehabil, Richmond, VA USA. [Riddick-Grisham, Susan] Care Planner Network, Richmond, VA USA. [Livingston, Lee A.] William Beaumont Army Med Ctr, Dept Behav Hlth, Ft Bliss, TX USA. RP Neufeld, JA (reprint author), Childrens Hosp & Res Ctr Oakland, Div Pediat Rehabil, Oakland, CA USA. NR 172 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-0359-2; 978-1-4398-0358-5 PY 2011 BP 377 EP 433 PG 57 WC Pediatrics; Rehabilitation SC Pediatrics; Rehabilitation GA BE4RU UT WOS:000372101300018 ER PT J AU Gutteridge, CE Thota, DS Curtis, SM Kozar, MP Li, QG Xie, LS Zhang, J Melendez, V Asher, C Luong, TT Gerena, L Nichols, DA Montip, G AF Gutteridge, Clare E. Thota, Darshan S. Curtis, Sean M. Kozar, Michael P. Li, Qigui Xie, Lisa Zhang, Jing Melendez, Victor Asher, Constance . Luong, Thulan T. Gerena, Lucia Nichols, Daniel A. Montip, Gettayacamin TI In vitro Biotransformation, in vivo Efficacy and Pharmacokinetics of Antimalarial Chalcones SO PHARMACOLOGY LA English DT Article DE Antiprotozoal activity; Biotransformation; 4 '-Butoxy-2,4-dimethoxy-chalcone; Chalcone; Malaria; 4 '-n-Butoxy-2,4-dimethoxy-chalcone; Microsomal digest; Pharmacokinetics ID PARASITE PLASMODIUM-FALCIPARUM; HUMAN LIVER-MICROSOMES; LICOCHALCONE-A; METABOLISM; DERIVATIVES; ANALOGS; AGENTS; RAT AB 4'-n-Butoxy-2,4-dimethoxy-chalcone (MBC) has been described as protecting mice from an otherwise lethal infection with Plasmodium yoelii when dosed orally at 50 mg/kg/ dose, daily for 5 days. In contrast, we found that oral dosing of MBC at 640 mg/kg/dose, daily for 5 days, failed to extend the survivability of P. berghei-infected mice. The timing of compound administration and metabolic activation likely contribute to the outcome of efficacy testing in vivo. Microsomal digest of MBC yielded 4'-n-butoxy-4-hydroxy-2-methoxy-chalcone and 4'-(1-hydroxy-n-butoxy)-2,4-dimethoxy-chalcone. We propose that the latter will hydrolyze in vivo to 4'-hydroxy-2,4-dimethoxy-chalcone, which has greater efficacy than MBC in our P. berghei-infected mouse model and was detected in plasma following oral dosing of mice with MBC. Pharmacokinetic parameters suggest that poor absorption, distribution, metabolism and excretion properties contribute to the limited in vivo efficacy observed for MBC and its analogs. Copyright (C) 2011 S. Karger AG, Basel C1 [Gutteridge, Clare E.; Thota, Darshan S.; Curtis, Sean M.] USN Acad, Dept Chem, Annapolis, MD 21402 USA. [Curtis, Sean M.; Kozar, Michael P.; Li, Qigui; Xie, Lisa; Zhang, Jing; Melendez, Victor; Asher, Constance .; Luong, Thulan T.; Gerena, Lucia; Nichols, Daniel A.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. [Montip, Gettayacamin] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Gutteridge, CE (reprint author), USN Acad, Dept Chem, 572M Holloway Rd,Mailstop 9B, Annapolis, MD 21402 USA. EM gutterid@usna.edu RI Kozar, Michael/A-9155-2011 FU Military Infectious Diseases Research Program; Research Corporation; Office of Naval Research; Naval Academy Research Council of the United States Naval Academy FX The authors gratefully acknowledge support of this work by the Military Infectious Diseases Research Program, the Research Corporation, the Office of Naval Research and the Naval Academy Research Council of the United States Naval Academy. Material has been reviewed by the Walter Reed Army Institute of Research. There is no objection to its publication. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or reflecting true views of the Department of the Army or the Department of Defense. NR 22 TC 7 Z9 7 U1 2 U2 9 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0031-7012 J9 PHARMACOLOGY JI Pharmacology PY 2011 VL 87 IS 1-2 BP 96 EP 104 DI 10.1159/000322532 PG 9 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 724FD UT WOS:000287560600015 PM 21282967 ER PT S AU Aranda, FJ Perry, J Archambault, D Belton, L Carlson, J Hoey, ML Ziegler, D Kimball, B AF Aranda, Francisco J. Perry, Jeffrey Archambault, Deana Belton, Lauren Carlson, Joel Hoey, Megan L. Ziegler, David Kimball, Brian BE Yin, S Guo, R TI Optical properties of woven arrays of bi-component extruded polymer fibers SO PHOTONIC FIBER AND CRYSTAL DEVICES: ADVANCES IN MATERIALS AND INNOVATIONS IN DEVICE APPLICATIONS V SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Photonic Fiber and Crystal Devices - Advances in Materials and Innovations in Device Applications V CY AUG 21-22, 2011 CL San Diego, CA SP SPIE DE Tri-component fiber; retro-reflection fiber; extrusion; refraction; diffraction; optical properties AB Directionally reflective fiber arrays were woven with polymer fibers. Fiber cross sections produced using a tri-component fiber extruder comprised standard circular as well as right angle retro-reflection features that run the entire length of the fiber. The fiber features are formed by an extrusion process where the polymer fiber material is forced through a series of plates resulting in the cross section having the desired shape. The woven fiber arrays were evaluated for their optical properties. Results for spectral reflectivity and spatial reflectance signature properties are presented. A comparison of the results obtained for the woven fiber arrays and those obtained for bundles of similar fibers are discussed. The implementation of fiber arrays through the use of weaving techniques allows for the realization of a number of unique and useful optical effects. As evidenced by the spectral measurements, the color of the woven arrays can be controlled by a number of means: for example by the inclusion of dyes, nanoparticles, and by post-processing applications of thin films. The present work represents a logical extension of previously reported experiments with unwoven fibers with retro-reflective features(1). C1 [Aranda, Francisco J.; Perry, Jeffrey; Archambault, Deana; Belton, Lauren; Carlson, Joel; Hoey, Megan L.; Ziegler, David; Kimball, Brian] USA, Fiber & Mat Phys Div, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Aranda, FJ (reprint author), USA, Fiber & Mat Phys Div, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. NR 5 TC 0 Z9 0 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-730-8 J9 PROC SPIE PY 2011 VL 8120 AR 81200J DI 10.1117/12.892775 PG 10 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BXY55 UT WOS:000297626200014 ER PT J AU Joshi, P Shewale, V Pandey, R Shanker, V Hussain, S Karna, SP AF Joshi, Prachi Shewale, Vasundhara Pandey, Ravindra Shanker, Virendra Hussain, Saber Karna, Shashi P. TI Site specific interaction between ZnO nanoparticles and tryptophan: a first principles quantum mechanical study SO PHYSICAL CHEMISTRY CHEMICAL PHYSICS LA English DT Article ID CLUSTERS; DESIGN AB First principles density functional theory calculations are performed on tryptophan-ZnO nanoparticles complex in order to study site specific interactions between tryptophan and ZnO. The calculated results find the salt bridge structure involving the -COOH group and ZnO cluster to be energetically more favorable than other interacting sites, such as indole and amine groups in tryptophan. The interaction between tryptophan and ZnO appears to be mediated by both ionic and hydrogen bonds. The calculated molecular orbital energy levels and charge distributions suggest non-radiative energy transfer from an excited state of tryptophan to states associated with ZnO, which may lead to a reduction in the emission intensity assigned to the pi pi* transition of the indole functional group of tryptophan. C1 [Joshi, Prachi; Shewale, Vasundhara; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [Shanker, Virendra] Natl Phys Lab CSIR, New Delhi 110012, India. [Karna, Shashi P.] USA, Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA. [Hussain, Saber] USAF, Res Lab, HEPB, Wright Patterson AFB, OH 45433 USA. RP Pandey, R (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. EM pandey@mtu.edu; shashi.karna@us.army.mil RI Shanker, Virendra/B-5338-2011 FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [611-243-2AFWP-00-104583] FX We acknowledge the support from the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (611-243-2AFWP-00-104583). Helpful discussions with Saikat Mukhopadhyay and Prof. Mrinalini Deshpande are acknowledged. PJ and VS also acknowledge the support received during their stay at Michigan Technological University. NR 14 TC 16 Z9 17 U1 0 U2 6 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1463-9076 J9 PHYS CHEM CHEM PHYS JI Phys. Chem. Chem. Phys. PY 2011 VL 13 IS 2 BP 476 EP 479 DI 10.1039/c0cp01466d PG 4 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 695RN UT WOS:000285390400015 PM 21031225 ER PT J AU Palmer, JC Moore, JD Roussel, TJ Brennan, JK Gubbins, KE AF Palmer, Jeremy C. Moore, Joshua D. Roussel, Thomas J. Brennan, John K. Gubbins, Keith E. TI Adsorptive behavior of CO2, CH4 and their mixtures in carbon nanospace: a molecular simulation study SO PHYSICAL CHEMISTRY CHEMICAL PHYSICS LA English DT Article ID GAS-PHASE ADSORPTION; ACTIVATED CARBON; PORE-SIZE; MONTE-CARLO; GRAPHITIC CARBON; ISOSTERIC HEAT; HENRY CONSTANT; SLIT PORES; FLUE-GAS; SEPARATION AB Using molecular simulation, four types of nanoporous carbons are examined as adsorbents for the separation of CO2/CH4 mixtures at ambient temperature and pressures up to 10 MPa. First, the adsorption selectivity of CO2 is investigated in carbon slit pores and single-walled carbon nanotube bundles in order to find the optimal pore dimensions for CO2 separation. Then, the adsorptive properties of the optimized slit pore and nanotube bundle are compared with two realistic nanoporous carbon models: a carbon replica of zeolite Y and an amorphous carbon. For the four carbon models, adsorption isotherms and isosteric heats of adsorption are presented for both pure components and mixtures. Special attention is given to the calculation of excess isotherms and isosteric heats, which are necessary to assess the performance of model nanoporous materials in the context of experimental measurements. From these results, we discuss the impact that variables such as pore size, pore morphology, pressure and mixture composition have on the performance of nanoporous carbons for CO2 separation. C1 [Palmer, Jeremy C.; Gubbins, Keith E.] N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA. [Moore, Joshua D.; Brennan, John K.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Roussel, Thomas J.] Consejo Super Invest Cient ICMAB CSIC, Inst Ciencia Mat Barcelona, Bellaterra 08193, Spain. RP Palmer, JC (reprint author), N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA. EM jcpalmer@ncsu.edu RI Roussel, Thomas/K-8780-2014 OI Roussel, Thomas/0000-0001-6004-3668 FU US Defense Threat Reduction Agency [AA07CBT011]; U.S. Army Research Laboratory; Consejo Superior de Investigaciones Cientificas of Spain; U.S. National Science Foundation [CHE080046N] FX J.C.P. gratefully acknowledges support from the US Defense Threat Reduction Agency (Project ID: AA07CBT011). J.D.M. acknowledges support in part by the Postdoctoral Program at the U.S. Army Research Laboratory, administered by Oak Ridge Associated Universities through a contract with the U.S. Army Research Laboratory. T.J.R. gratefully acknowledges support from the NANOSELECT project from the Programa Ingenio 2010 of the Consejo Superior de Investigaciones Cientificas of Spain. Computational time was provided through a Teragrid Research Allocation by the U.S. National Science Foundation (grant. no. CHE080046N). NR 64 TC 31 Z9 31 U1 3 U2 33 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1463-9076 J9 PHYS CHEM CHEM PHYS JI Phys. Chem. Chem. Phys. PY 2011 VL 13 IS 9 BP 3985 EP 3996 DI 10.1039/c0cp02281k PG 12 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 722DP UT WOS:000287411700049 PM 21234499 ER PT J AU Ma, XF Chakraborty, P Henz, BJ Zachariah, MR AF Ma, Xiaofei Chakraborty, Purnendu Henz, Brian J. Zachariah, Michael R. TI Molecular dynamic simulation of dicarboxylic acid coated aqueous aerosol: structure and processing of water vapor SO PHYSICAL CHEMISTRY CHEMICAL PHYSICS LA English DT Article ID CONDENSATION COEFFICIENT; LIQUID/VAPOR INTERFACE; AIR/WATER INTERFACE; ORGANIC AEROSOLS; SURFACE-TENSION; HYDROPHOBICITY; NANOAEROSOLS; EVAPORATION; ACTIVATION; PARTICLES AB Organic monolayers at the surfaces of aqueous aerosols play an important role in determining the mass, heat transfer rate and surface reactivity of atmospheric aerosols. They can potentially contribute to the formation of cloud condensation nuclei (CCN) and are involved in a series of chemical reactions occurring in atmosphere. Recent studies even suggest that organic-coated interfaces could have played some role in prebiotic biochemistry and the origin of life. However, creating reproducible, well-characterized aqueous aerosol particles coated with organic films is an experimental challenge. This opens the opportunity for computer simulations and modeling of these complex structures. In this work, molecular dynamics simulation was used to probe the structure and the interfacial properties of the dicarboxylic acid coated aqueous aerosol. Low molecular weight dicarboxylic acids of various chain lengths and water solubility were chosen to coat a water droplet consisting of 2440 water molecules. For malonic acid coated aerosol, the surface acid molecules dissolved into the water core and formed an ordered structure due to the hydrophobic interactions. The acid and the water are separated inside the aerosol. For other nanoaerosols coated with low solubility acids, phase separation between water and acid molecules was observed on the surface of the particle. To study the water processing of the coated aerosols, the water vapor accommodation factors were calculated. C1 [Ma, Xiaofei; Chakraborty, Purnendu; Zachariah, Michael R.] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. [Ma, Xiaofei; Chakraborty, Purnendu; Zachariah, Michael R.] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA. [Zachariah, Michael R.] NIST, Gaithersburg, MD 20899 USA. [Henz, Brian J.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Zachariah, MR (reprint author), Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. EM mrz@umd.edu RI Ma, Xiaofei/B-3569-2011; Chakraborty, Purnendu/E-8502-2011 FU National Science Foundation; National Institute of Standards and Technology FX The authors wish to acknowledge the support of a National Science Foundation-NIRT grant and the National Institute of Standards and Technology. NR 36 TC 20 Z9 20 U1 6 U2 41 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1463-9076 J9 PHYS CHEM CHEM PHYS JI Phys. Chem. Chem. Phys. PY 2011 VL 13 IS 20 BP 9374 EP 9384 DI 10.1039/c0cp01923b PG 11 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 759FA UT WOS:000290224900038 PM 21479309 ER PT J AU Taylor, DE Rob, F Rice, BM Podeszwa, R Szalewicz, K AF Taylor, DeCarlos E. Rob, Fazle Rice, Betsy M. Podeszwa, Rafal Szalewicz, Krzysztof TI A molecular dynamics study of 1,1-diamino-2,2-dinitroethylene (FOX-7) crystal using a symmetry adapted perturbation theory-based intermolecular force field SO PHYSICAL CHEMISTRY CHEMICAL PHYSICS LA English DT Article ID DENSITY-FUNCTIONAL THEORY; KOHN-SHAM ORBITALS; EQUATION-OF-STATE; AB-INITIO; DISPERSION CORRECTION; INTERACTION ENERGIES; MONOMERS; DIMER; PREDICTION; EXCHANGE AB A dimer potential energy function for 1,1-diamino-2,2-dinitroethylene (FOX-7) has been developed using symmetry adapted perturbation theory based on a Kohn-Sham density functional theory description of the monomers [SAPT(DFT)]. Interaction energies of 1008 dimer configurations were computed in an augmented double zeta basis set and fitted to an atom-atom intermolecular potential energy function of Coulomb plus Buckingham exp-6 form. The potential was used in isothermal-isostress molecular dynamics simulations to study the structure and thermal/pressure response of FOX-7 crystal. The simulated structure is in very good agreement with experiment and the computed thermal/pressure response of the crystal shows significant anisotropy with respect to crystallographic direction, in-line with experimental observations. It is concluded that SAPT(DFT) is an excellent method for development of intermolecular potentials for energetic molecular crystals. C1 [Taylor, DeCarlos E.; Rice, Betsy M.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Rob, Fazle; Szalewicz, Krzysztof] Univ Delaware, Dept Phys & Astron, Newark, DE 19716 USA. [Podeszwa, Rafal] Univ Silesia, Inst Chem, PL-40006 Katowice, Poland. RP Taylor, DE (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM decarlos.taylor@us.army.mil; frob@udel.edu; betsy.rice@us.army.mil; poszwa@tiger.chem.uw.edu.pl; szalewic@udel.edu FU Army Research Office; NSF [CHE-0848589]; Polish Ministry of Science and Higher Education [N N04 123337] FX D.E.T would like to thank the High Performance Computing Modernization Program for computer time under Challenge Project number ARLAPC4N at several Defense Shared Resource Centers within the Department of Defense. The work at UD has been supported by the Army Research Office and by NSF grant CHE-0848589. R.P. acknowledges support by the Polish Ministry of Science and Higher Education grant No. N N04 123337. NR 41 TC 23 Z9 24 U1 0 U2 30 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1463-9076 J9 PHYS CHEM CHEM PHYS JI Phys. Chem. Chem. Phys. PY 2011 VL 13 IS 37 BP 16629 EP 16636 DI 10.1039/c1cp21342c PG 8 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 815BS UT WOS:000294501700020 PM 21860866 ER PT J AU Couch, KS Stojadinovic, A AF Couch, Kara S. Stojadinovic, Alexander TI Negative-Pressure Wound Therapy in the Military: Lessons Learned SO PLASTIC AND RECONSTRUCTIVE SURGERY LA English DT Article ID VACUUM-ASSISTED CLOSURE; IRRIGATION; MANAGEMENT; BLOOD; MODEL; EXPERIENCE; INJURIES; SYSTEM; SALINE; WATER AB The utilization of negative pressure for medicinal purposes dates back to 600 BC. The U.S. military has been engaged in continuous overseas combat operations since 2001. Negative-pressure wound therapy has been in use in the treatment of casualties from these operations since 2004. It represents a new standard of practice in combat wound care; it promotes granulation tissue formation and creates mechanical forces supporting wound contraction, facilitating definitive wound closure. This article describes (1) the use of negative-pressure wound therapy in combat casualty care, (2) inherent challenges of its use in theater of operations and across the echelons of care, (3) modifications of this wound therapy to meet military-specific needs, and (4) future directions with this novel wound care modality. (Plast. Reconstr. Sing 127 (Suppl.): 117S, 2011.) C1 [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Complex Wound & Limb Salvage Ctr, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Combat Wound Initiat Program, Washington, DC 20307 USA. RP Stojadinovic, A (reprint author), Walter Reed Army Med Ctr, Dept Surg, Complex Wound & Limb Salvage Ctr, 6900 Georgia Ave,Room 5C27A NW, Washington, DC 20307 USA. EM alexander.stojadinovic@amedd.army.mil FU Combat Wound Initiative Program, Washington, D.C. FX This clinical research effort was supported, in part, by the Combat Wound Initiative Program, Washington, D.C. NR 36 TC 12 Z9 13 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0032-1052 J9 PLAST RECONSTR SURG JI Plast. Reconstr. Surg. PD JAN PY 2011 VL 127 IS 1 SU S BP 117S EP 130S DI 10.1097/PRS.0b013e3181fd344e PG 14 WC Surgery SC Surgery GA 705IP UT WOS:000286122400018 PM 21200282 ER PT J AU Aldstadt, J Koenraadt, CJM Fansiri, T Kijchalao, U Richardson, J Jones, JW Scott, TW AF Aldstadt, Jared Koenraadt, Constantianus J. M. Fansiri, Thanyalak Kijchalao, Udom Richardson, Jason Jones, James W. Scott, Thomas W. TI Ecological Modeling of Aedes aegypti (L.) Pupal Production in Rural Kamphaeng Phet, Thailand SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID PRIMARY-SCHOOL CHILDREN; DENGUE VECTOR; CULICIDAE PRODUCTIVITY; PUERTO-RICO; TRANSMISSION; DIPTERA; SURVEILLANCE; DISPERSAL; EPIDEMIOLOGY; POPULATION AB Background: Aedes aegypti (L.) is the primary vector of dengue, the most important arboviral infection globally. Until an effective vaccine is licensed and rigorously administered, Ae. aegypti control remains the principal tool in preventing and curtailing dengue transmission. Accurate predictions of vector populations are required to assess control methods and develop effective population reduction strategies. Ae. aegypti develops primarily in artificial water holding containers. Release recapture studies indicate that most adult Ae. aegypti do not disperse over long distances. We expect, therefore, that containers in an area of high development site density are more likely to be oviposition sites and to be more frequently used as oviposition sites than containers that are relatively isolated from other development sites. After accounting for individual container characteristics, containers more frequently used as oviposition sites are likely to produce adult mosquitoes consistently and at a higher rate. To this point, most studies of Ae. aegypti populations ignore the spatial density of larval development sites. Methodology: Pupal surveys were carried out from 2004 to 2007 in rural Kamphaeng Phet, Thailand. In total, 84,840 samples of water holding containers were used to estimate model parameters. Regression modeling was used to assess the effect of larval development site density, access to piped water, and seasonal variation on container productivity. A varying-coefficients model was employed to account for the large differences in productivity between container types. A two-part modeling structure, called a hurdle model, accounts for the large number of zeroes and overdispersion present in pupal population counts. Findings: The number of suitable larval development sites and their density in the environment were the primary determinants of the distribution and abundance of Ae. aegypti pupae. The productivity of most container types increased significantly as habitat density increased. An ecological approach, accounting for development site density, is appropriate for predicting Ae. aegypti population levels and developing efficient vector control programs. C1 [Aldstadt, Jared] SUNY Buffalo, Dept Geog, Buffalo, NY 14260 USA. [Koenraadt, Constantianus J. M.] Wageningen Univ, Entomol Lab, Wageningen, Netherlands. [Fansiri, Thanyalak; Kijchalao, Udom; Jones, James W.] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Richardson, Jason] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD USA. [Scott, Thomas W.] Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA. [Scott, Thomas W.] NIH, Fogarty Int Ctr, Bethesda, MD USA. RP Aldstadt, J (reprint author), SUNY Buffalo, Dept Geog, Buffalo, NY 14260 USA. EM geojared@buffalo.edu RI Richardson, Jason/A-9441-2011; Aldstadt, Jared/A-8508-2009 OI Aldstadt, Jared/0000-0001-9162-7439 FU National Institutes of Health (NIH) [AI-034533] FX This study was supported by National Institutes of Health (NIH) grant AI-034533. This research benefited from discussions with working group members in the Research and Policy for Infectious Disease Dynamics (RAPIDD) program of the Science and Technology Directorate, Department of Homeland Security, and the Fogarty International Center, NIH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 49 TC 20 Z9 20 U1 0 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD JAN PY 2011 VL 5 IS 1 AR e940 DI 10.1371/journal.pntd.0000940 PG 17 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 711MP UT WOS:000286596000017 PM 21267055 ER PT J AU Huang, IC Bailey, CC Weyer, JL Radoshitzky, SR Becker, MM Chiang, JJ Brass, AL Ahmed, AA Chi, XL Dong, LA Longobardi, LE Boltz, D Kuhn, JH Elledge, SJ Bavari, S Denison, MR Choe, H Farzan, M AF Huang, I-Chueh Bailey, Charles C. Weyer, Jessica L. Radoshitzky, Sheli R. Becker, Michelle M. Chiang, Jessica J. Brass, Abraham L. Ahmed, Asim A. Chi, Xiaoli Dong, Lian Longobardi, Lindsay E. Boltz, Dutch Kuhn, Jens H. Elledge, Stephen J. Bavari, Sina Denison, Mark R. Choe, Hyeryun Farzan, Michael TI Distinct Patterns of IFITM-Mediated Restriction of Filoviruses, SARS Coronavirus, and Influenza A Virus SO PLOS PATHOGENS LA English DT Article ID ANGIOTENSIN-CONVERTING ENZYME-2; MEMBRANE-FUSION; RECEPTOR-BINDING; CATHEPSIN-L; CELLS; ENTRY; GLYCOPROTEIN; ENDOCYTOSIS; INFECTION; PROTEIN AB Interferon-inducible transmembrane proteins 1, 2, and 3 (IFITM1, 2, and 3) are recently identified viral restriction factors that inhibit infection mediated by the influenza A virus (IAV) hemagglutinin (HA) protein. Here we show that IFITM proteins restricted infection mediated by the entry glycoproteins (GP(1,2)) of Marburg and Ebola filoviruses (MARV, EBOV). Consistent with these observations, interferon-beta specifically restricted filovirus and IAV entry processes. IFITM proteins also inhibited replication of infectious MARV and EBOV. We observed distinct patterns of IFITM-mediated restriction: compared with IAV, the entry processes of MARV and EBOV were less restricted by IFITM3, but more restricted by IFITM1. Moreover, murine Ifitm5 and 6 did not restrict IAV, but efficiently inhibited filovirus entry. We further demonstrate that replication of infectious SARS coronavirus (SARS-CoV) and entry mediated by the SARS-CoV spike (S) protein are restricted by IFITM proteins. The profile of IFITM-mediated restriction of SARS-CoV was more similar to that of filoviruses than to IAV. Trypsin treatment of receptor-associated SARS-CoV pseudovirions, which bypasses their dependence on lysosomal cathepsin L, also bypassed IFITM-mediated restriction. However, IFITM proteins did not reduce cellular cathepsin activity or limit access of virions to acidic intracellular compartments. Our data indicate that IFITM-mediated restriction is localized to a late stage in the endocytic pathway. They further show that IFITM proteins differentially restrict the entry of a broad range of enveloped viruses, and modulate cellular tropism independently of viral receptor expression. C1 [Huang, I-Chueh; Bailey, Charles C.; Weyer, Jessica L.; Chiang, Jessica J.; Farzan, Michael] Harvard Univ, Sch Med, New England Primate Res Ctr, Dept Microbiol & Mol Genet, Southborough, MA 01772 USA. [Radoshitzky, Sheli R.; Chi, Xiaoli; Dong, Lian; Longobardi, Lindsay E.; Boltz, Dutch; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD USA. [Becker, Michelle M.; Denison, Mark R.] Vanderbilt Univ, Med Ctr, Dept Pediat, Nashville, TN 37232 USA. [Becker, Michelle M.; Denison, Mark R.] Vanderbilt Univ, Med Ctr, Dept Microbiol & Immunol, Nashville, TN 37232 USA. [Becker, Michelle M.; Denison, Mark R.] Vanderbilt Univ, Med Ctr, Elizabeth B Lamb Ctr Pediat Res, Nashville, TN 37232 USA. [Brass, Abraham L.] Ragon Inst Massachusetts Gen Hosp MIT & Harvard M, Charlestown, MA USA. [Ahmed, Asim A.; Choe, Hyeryun] Harvard Univ, Childrens Hosp, Sch Med, Dept Pediat, Boston, MA 02115 USA. [Kuhn, Jens H.] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD USA. [Kuhn, Jens H.] Tunnell Consulting Inc, King Of Prussia, PA USA. [Elledge, Stephen J.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Howard Hughes Med Inst,Dept Genet, Boston, MA 02115 USA. RP Huang, IC (reprint author), Harvard Univ, Sch Med, New England Primate Res Ctr, Dept Microbiol & Mol Genet, Southborough, MA 01772 USA. EM I-Chueh_Huang@hms.harvard.edu; farzan@hms.harvard.edu RI Kuhn, Jens H./B-7615-2011 OI Kuhn, Jens H./0000-0002-7800-6045 FU New England Regional Center for Excellence/Biodefense and Emerging Infectious Disease [U54 AI057159]; Burroughs Welcome Fund; Southeast Regional Center of Excellence for Emerging Infections and Biodefense [U54 AI057157] FX This work was supported by the New England Regional Center for Excellence/Biodefense and Emerging Infectious Disease (U54 AI057159), by the Burroughs Welcome Fund, and by Southeast Regional Center of Excellence for Emerging Infections and Biodefense (U54 AI057157). The content of this publication does not necessarily reflect the views or policies of the US Department of Health and Human Services, the US Department of Defense, the US Department of the Army or the institutions and companies affiliated with the authors. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 26 TC 152 Z9 171 U1 4 U2 35 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1553-7366 J9 PLOS PATHOG JI PLoS Pathog. PD JAN PY 2011 VL 7 IS 1 AR e1001258 DI 10.1371/journal.ppat.1001258 PG 13 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA 712GL UT WOS:000286654100015 PM 21253575 ER PT J AU Stokes, KK Orlicki, JA Beyer, FL AF Stokes, Kristoffer K. Orlicki, Joshua A. Beyer, Frederick L. TI RAFT polymerization and thermal behavior of trimethylphosphonium polystyrenes for anion exchange membranes SO POLYMER CHEMISTRY LA English DT Article ID SOLUTION VISCOSITY BEHAVIOR; FUEL-CELLS; CATIONIC IONOMERS; MORPHOLOGY AB Ionomers of trimethyl(4-vinylbenzyl) phosphonium chloride and styrene comonomers were synthesized with between 15 and 98 mol% ionic content. The thermal properties were explored and a significant increase in the glass transition of the high ion content polymers was found, most likely due to ion aggregation into clusters. C1 [Stokes, Kristoffer K.; Orlicki, Joshua A.; Beyer, Frederick L.] USA, Mat & Mfg Sci Div, Res Lab, Aberdeen Proving Ground, MD USA. RP Stokes, KK (reprint author), Celgard LLC, Charlotte, NC USA. EM kstokes@celgard.com; rick.beyer@us.army.mil RI Paquette, Joseph/O-4271-2015 OI Paquette, Joseph/0000-0001-6023-5125 FU US Department of Energy [ORISE 1120-1120-99]; Army Research Laboratory [ORISE 1120-1120-99] FX This research was supported in part by the appointment of KKS to the Postgraduate Research Participation Program at the US Army Research Laboratory, administered by the Oak Ridge Institute of Science and Education through an interagency agreement between the US Department of Energy and Army Research Laboratory (contract no. ORISE 1120-1120-99). The identification of commercial equipment and materials in this paper is used to specify adequately the experimental procedures and does not imply recommendations by the Army Research Laboratory. NR 15 TC 29 Z9 30 U1 1 U2 32 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1759-9954 J9 POLYM CHEM-UK JI Polym. Chem. PY 2011 VL 2 IS 1 BP 80 EP 82 DI 10.1039/c0py00293c PG 3 WC Polymer Science SC Polymer Science GA 691FW UT WOS:000285066700008 ER PT S AU Burk, RC Parnell, GS AF Burk, Roger Chapman Parnell, Gregory S. BE Salo, A Keisler, J Morton, A TI Portfolio Decision Analysis: Lessons from Military Applications SO PORTFOLIO DECISION ANALYSIS: IMPROVED METHODS FOR RESOURCE ALLOCATION SE International Series in Operations Research & Management Science LA English DT Article; Book Chapter ID VALUE MODEL; SYSTEMS; AIR; INVESTMENT AB We review the use of portfolio decision analysis in military applications, such as weapon systems, types of forces, installations, and military research and development projects. We start by comparing military and commercial portfolio problems in general, discussing the distinguishing characteristics of the military decision environment: hostile and adaptive adversaries, a public decision process with multiple stakeholders, and high system complexity. Then we list and summarize 24 military DA applications published from 1992 to 2010. We find that the most widespread prominent feature of these applications is the careful modeling of value from multiple objectives. Mathematical optimization is not so common, but it can be important when a large number of interdependencies or side constraints makes it hard to find good feasible candidate portfolios. Quantitative methods of accounting for risk are surprisingly rare, considering the high level of uncertainty in the military environment. We analyze six of the applications in more detail, looking at how they model portfolio value calculation, swing weight assessment, constraints and dependencies, and uncertainty and risk. An appendix provides a recommended procedure for portfolio decision analysis based on the authors' experience and the applications reviewed. C1 [Burk, Roger Chapman; Parnell, Gregory S.] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. RP Burk, RC (reprint author), US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. EM roger.burk@usma.edu; gparnell@innovativedecisions.com NR 42 TC 7 Z9 7 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 0884-8289 BN 978-1-4419-9942-9 J9 INT SER OPER RES MAN PY 2011 VL 162 BP 333 EP 357 DI 10.1007/978-1-4419-9943-6_14 D2 10.1007/978-1-4419-9943-6 PG 25 WC Operations Research & Management Science SC Operations Research & Management Science GA BWO21 UT WOS:000294382900014 ER PT J AU Schwartz, RB McManus, JG Croushorn, J Piazza, G Coule, PL Gibbons, M Bollard, G Ledrick, D Vecchio, P Lerner, EB AF Schwartz, Richard Bruce McManus, John G., Jr. Croushorn, John Piazza, Gina Coule, Phillip L. Gibbons, Mark Bollard, Glenn Ledrick, David Vecchio, Paul Lerner, E. Brooke TI Tactical Medicine-Competency-Based Guidelines SO PREHOSPITAL EMERGENCY CARE LA English DT Article AB Background. Tactical emergency medical support (TEMS) is a rapidly growing area within the field of prehospital medicine. As TEMS has grown, multiple training programs have emerged. A review of the existing programs demonstrated a lack of competency-based education. Objective. To develop educational competencies for TEMS as a first step toward enhancing accountability. Methods. As an initial attempt to establish accepted outcome-based competencies, the National Tactical Officers Association (NTOA) convened a working group of subject matter experts. Results. This working group drafted a competency-based educational matrix consisting of 18 educational domains. Each domain included competencies for four educational target audiences (operator, medic, team commander, and medical director). The matrix was presented to the American College of Emergency Physicians (ACEP) Tactical Emergency Medicine Section members. A modified Delphi technique was utilized for the NTOA and ACEP groups, which allowed for additional expert input and consensus development. Conclusion. The resultant matrix can serve as the basic educational standard around which TEMS training organizations can design programs of study for the four target audiences. C1 [Schwartz, Richard Bruce; Piazza, Gina; Coule, Phillip L.] Med Coll Georgia, Dept Emergency Med, Augusta, GA 30912 USA. [Schwartz, Richard Bruce; Piazza, Gina; Vecchio, Paul] Med Coll Georgia, Ctr Operat Med, Augusta, GA 30912 USA. [McManus, John G., Jr.; Croushorn, John] Brooke Army Med Ctr, Dept Emergency Med, Ft Sam Houston, TX 78234 USA. [Gibbons, Mark] Natl Tact Officers Assoc, Baltimore, MD USA. [Ledrick, David] St Vincents Mercy Med Ctr, Dept EmergencyMedicine, Toledo, OH USA. [Lerner, E. Brooke] Med Coll Wisconsin, Dept Emergency Med, Milwaukee, WI 53226 USA. [Bollard, Glenn] Amer Coll Emergency Phys, TEMS Sect, Irving, TX USA. RP Schwartz, RB (reprint author), Med Coll Georgia, Dept Emergency Med, 1120 15th St, Augusta, GA 30912 USA. EM rschwartz@mcg.edu NR 16 TC 7 Z9 7 U1 0 U2 2 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1090-3127 J9 PREHOSP EMERG CARE JI Prehosp. Emerg. Care PD JAN PY 2011 VL 15 IS 1 BP 67 EP 82 DI 10.3109/10903127.2010.514092 PG 16 WC Emergency Medicine; Public, Environmental & Occupational Health SC Emergency Medicine; Public, Environmental & Occupational Health GA 684GS UT WOS:000284539000013 PM 20858134 ER PT S AU Gallant, S Gaughan, C AF Gallant, Scott Gaughan, Chris BE Jain, S Creasey, R Himmelspach, J TI DIFFICULTIES WITH TRUE INTEROPERABILITY IN MODELING & SIMULATION SO PROCEEDINGS OF THE 2011 WINTER SIMULATION CONFERENCE (WSC) SE Winter Simulation Conference Proceedings LA English DT Proceedings Paper CT Winter Simulation Conference (WSC)/Conference on Modeling and Analysis for Semiconductor Manufacturing (MASM) CY DEC 11-14, 2011 CL Phoenix, AZ SP Amer Stat Assoc (ASA), Assoc Comp Machinery-Special Interest Grp Simulat (ACM/SIGSIM), Inst Elect & Electron Engineers-Syst, Man, & Cybernet Soc (IEEE/SMC), Inst Ind Engineers (IIE), Inst Operat Res & Management Sci-Simulat Soc (INFORMS-SIM), Natl Inst Stand & Technol (NIST), Soc Modeling & Simulat Int (SCS) AB Interoperability among distributed models and simulations is complex, tedious and difficult to evaluate. Integrating models that were developed for various purposes with disparate technologies and managed by independent organizations is often the goal. This goal is underestimated due to misleading facts of com-monalities between those applications. Common compliance with middleware architectures, modeling goals and even object models gives a false impression of complete interoperability. There are numerous considerations when developing a distributed simulation environment. The event's objectives drive the necessary simulation functions, but how those simulation functions interact needs to be meticulously designed for true interoperability. The semantics of the information transmitted, the behavior necessary across multiple applications, fidelity and resolution synchronization are only a subset of the systems engineering necessary for a coherent System of Systems. This paper covers interoperability complexities and proposes criteria to consider when developing, integrating and executing a distributed modeling and simulation architecture. C1 [Gallant, Scott] Effect Applicat Corp, Orlando, FL USA. [Gaughan, Chris] US Army Res Lab, Simulat & Training Technol Ctr, Orlando, FL 32801 USA. RP Gallant, S (reprint author), Effect Applicat Corp, Orlando, FL USA. EM scott@effectiveapplications.com; chris.gaughan@us.army.mil NR 23 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0891-7736 BN 978-1-4577-2109-0 J9 WINT SIMUL C PROC PY 2011 BP 2637 EP 2648 PG 12 WC Computer Science, Information Systems; Engineering, Electrical & Electronic; Operations Research & Management Science SC Computer Science; Engineering; Operations Research & Management Science GA BYU80 UT WOS:000300520802086 ER PT S AU Chen, JYC Barnes, MJ Kenny, C AF Chen, Jessie Y. C. Barnes, Michael J. Kenny, Caitlin GP IEEE TI Effects of Unreliable Automation and Individual Differences on Supervisory Control of Multiple Ground Robots SO PROCEEDINGS OF THE 6TH ACM/IEEE INTERNATIONAL CONFERENCE ON HUMAN-ROBOT INTERACTIONS (HRI 2011) SE ACMIEEE International Conference on Human-Robot Interaction LA English DT Proceedings Paper CT 6th ACM/IEEE International Conference on Human-Robot Interaction (HRI) CY MAR 06-09, 2011 CL Lausanne, SWITZERLAND SP ACM, IEEE, IEEE Robot & Automat, ACM SIGCHI, ACM SIGART, AAAI, Human Factors & Ergon Soc, IEEE Syst Man & Cybernet Soc DE Human Robot Interaction; Simulation; Military; Imperfect Automation; Individual Differences; Multitasking ID PERFORMANCE AB A military multitasking environment was simulated to examine the effects of unreliable automation on the performance of robotics operators. The main task was to manage a team of four ground robots with the assistance of RoboLeader, an intelligent agent capable of coordinating the robots and changing their routes based upon developments in the mission environment. RoboLeader's recommendations were manipulated to be either false-alarm prone or miss prone, with a reliability level of either 60% or 90%. The visual density of the targeting environment was manipulated by the presence or absence of friendly soldiers. Results showed that the type of RoboLeader unreliability (false-alarm vs. miss prone) affected operator's performance of tasks involving visual scanning (target detection, route editing, and situation awareness). There was a consistent effect of visual density for multiple performance measures. Participants with higher spatial ability performed better on the two tasks that required the most visual scanning (target detection and route editing). Participants' attentional control impacted their overall multitasking performance, especially during their execution of the secondary tasks (communication and gauge monitoring). C1 [Chen, Jessie Y. C.] US Army Res Lab, 12423 Res Pkwy, Orlando, FL 32826 USA. [Barnes, Michael J.] US Army Res Lab, Ft Huachuca, AZ 85613 USA. [Kenny, Caitlin] Univ Cent Florida, Orlando, FL 32826 USA. RP Chen, JYC (reprint author), US Army Res Lab, 12423 Res Pkwy, Orlando, FL 32826 USA. EM jessie.chen@us.army.mil; michael.j.barnes@us.army.mil; ckenny@ist.ucf.edu FU U.S. Army's SOURCE ATO FX This research was funded by U.S. Army's SOURCE ATO. RoboLeader was developed under a U.S. Army Research Laboratory (ARL) Director's Research Initiative (DRI) project in FY09. The authors wish to thank Zhihua Qu, Mark Snyder, and Daniel Barber of Univ. of Central Florida for their contributions. NR 32 TC 1 Z9 1 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2167-2121 BN 978-1-4503-0561-7 J9 ACMIEEE INT CONF HUM PY 2011 BP 371 EP 378 DI 10.1145/1957656.1957793 PG 8 WC Computer Science, Cybernetics; Engineering, Electrical & Electronic; Robotics SC Computer Science; Engineering; Robotics GA BG9JJ UT WOS:000393313200126 ER PT J AU Acosta, J AF Acosta, Jaime BE Armistead, L TI Using the Longest Common Substring on Dynamic Traces of Malware to Automatically Identify Common Behaviors SO PROCEEDINGS OF THE 6TH INTERNATIONAL CONFERENCE ON INFORMATION WARFARE AND SECURITY LA English DT Proceedings Paper CT 6th International Conference on Information Warfare and Security (ICIW) CY MAR 17-18, 2011 CL George Washington Univ, Washington, DC HO George Washington Univ DE malware; similarity; dynamic; analysis; substring AB A large amount of research is focused on identifying malware. Once identified, the behavior of the malware must be analyzed to determine its effects on a system. This can be done by tracing through a malware binary using a disassembler or logging its dynamic behavior using a sandbox (virtual machines that execute a binary and log all dynamic events such as network, registry, and file manipulations). However, even with these tools, analyzing malware behavior is very time consuming for an analyst. In order to alleviate this, recent work has identified methods to categorize malware into "clusters" or types based on common dynamic behavior. This allows a human analyst to look at only a fraction of malware instances-those most dissimilar. Still missing are techniques that identify similar behaviors among malware of different types. Also missing is a way to automatically identify differences among same-type malware instances to determine whether the differences are benign or are the key malicious behavior. The research presented here shows that a wide collection of malware instances have common dynamic behavior regardless of their type. This is a first step toward enabling an analyst to more efficiently identify malware instances' effects on systems by reducing the need for redundant analysis and allowing filtration of common benign behavior. This research uses the publicly available Reference Data Set that was collected over a period of three years. Malware instances were identified and assigned a type by six anti-malware scanners. The dataset consists of dynamic trace events of 3131 malware instances generated by CWSandbox. For this research, the dataset is separated into two sets: small and large. The small set contains 2071 instances of malware that are less than 100 KB in size. The large set contains 1060 instances of malware that are between 100 KB and 3.4 MB in size. In order to measure the common behavior between the small and large sets, common sequential event sequences within each malware instance in the small set are identified using a modified version of the longest common substring algorithm. Once identified, all appearances of these common event sequences are removed from the large set to determine shared behavior. Most common sequences are between length 2 and 60 events. Results indicate that when using length 2 event sequences and higher, on average, the large set instances share 96% of event sequences, with length 6 and higher event sequences-66%, and with length 12 and higher event sequences-50%. This indicates that an analyst's workload can be largely reduced by removing common behavior sequences. Furthermore, it shows that malware instances may not always fall into exclusive categories. It may be more beneficial to instead identify behaviors and map them to malware instances, for example, as with the Malware Attribute Enumeration and Characterization (MAEC). Future efforts may look into attaching semantic labels on long sequences that are common to many malware instances in order to aid the analyst further. C1 USA, Res Lab, White Sands Missile Range, NM USA. RP Acosta, J (reprint author), USA, Res Lab, White Sands Missile Range, NM USA. EM jaime.acosta1@us.army.mil NR 21 TC 0 Z9 0 U1 0 U2 1 PU ACAD CONFERENCES LTD PI NR READING PA CURTIS FARM, KIDMORE END, NR READING, RG4 9AY, ENGLAND BN 978-1-906638-92-4 PY 2011 BP 1 EP 7 PG 7 WC Computer Science, Theory & Methods SC Computer Science GA BET38 UT WOS:000318019700001 ER PT B AU Newendorp, BJ Noon, C Holub, J Winer, EH Gilbert, S de la Cruz, J AF Newendorp, Brandon J. Noon, Christian Holub, Joe Winer, Eliot H. Gilbert, Stephen de la Cruz, Julio GP ASME TI CONFIGURING VIRTUAL REALITY DISPLAYS IN A MIXED-REALITY ENVIRONMENT FOR LVC TRAINING SO PROCEEDINGS OF THE ASME WORLD CONFERENCE ON INNOVATIVE VIRTUAL REALITY - 2011 LA English DT Proceedings Paper CT ASME World Conference on Innovative Virtual Reality (WinVR2011) CY JUN 27-29, 2011 CL Politecnico Milano, Milan, ITALY SP Amer Soc Mech Engineers, Transportat Div HO Politecnico Milano AB In order to adapt to an ever-changing set of threats, military forces need to find new methods of training. The prevalence of commercial game engines combined with virtual reality (VR) and mixed reality environments can prove beneficial to training. Live, virtual and constructive (LVC) training combines live people, virtual environments and simulated actors to create a better training environment. However, integrating virtual reality displays, software simulations and artificial weapons into a mixed reality environment poses numerous challenges. A mixed reality environment known as The Veldt was constructed to research these challenges. The Veldt consists of numerous independent displays, along with movable walls, doors and windows. This allows The Veldt to simulate numerous training scenarios. Several challenges were encountered in creating this system. Displays were precisely located using the tracking system, then configured using VR Juggler. The ideal viewpoint for each display was configured based on the expect location for users to be looking at it. Finally, the displays were accurately aligned to the virtual terrain model. This paper describes how the displays were configured in The Veldt, as well as how it was used for two training scenarios. C1 [Newendorp, Brandon J.; Noon, Christian; Holub, Joe; Winer, Eliot H.; Gilbert, Stephen] Iowa State Univ, Virtual Real Applicat Ctr, Ames, IA 50011 USA. [de la Cruz, Julio] US Army RDECOM, Simulat & Training Technol Ctr, Orlando, FL USA. RP Newendorp, BJ (reprint author), Iowa State Univ, Virtual Real Applicat Ctr, Ames, IA 50011 USA. EM bnewendorp@gmail.com NR 22 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4432-8 PY 2011 BP 423 EP + PG 2 WC Engineering, Manufacturing; Engineering, Mechanical SC Engineering GA BFJ19 UT WOS:000320069200048 ER PT J AU He, T Swami, A Lee, KW AF He, Ting Swami, Ananthram Lee, Kang-Won GP ACM TI Dispatch-and-Search: Dynamic Multi-Ferry Control in Partitioned Mobile Networks SO PROCEEDINGS OF THE TWELFTH ACM INTERNATIONAL SYMPOSIUM ON MOBILE AD HOC NETWORKING AND COMPUTING (MOBIHOC' 11) LA English DT Proceedings Paper CT 12th ACM International Symposium on Mobile Ad Hoc Networking and Computing CY MAY 16-20, 2011 CL Paris, FRANCE SP ACM DE Data ferry control; Partially Observable Markov Decision Processes; Myopic control policies AB We consider the problem of disseminating data from a base station to a sparse, partitioned mobile network by controllable data ferries with limited ferry-node and ferry-ferry communication ranges. Existing solutions to data ferry control mostly assume the nodes to be stationary,which reduces the problem to designing fixed ferry routes. In the more challenging scenario of mobile networks,existing solutions have focused on single-ferry control and left out an import antissue of ferry cooperation in the presence of multiple ferries. In this paper, we jointly address the issues of ferry navigation and cooperation using the approach of stochastic control. Under the assumption that ferries can communicate within each partition,we propose a hierarchical control system called Dispatch-and-Search(DAS),consisting of a global controller that dispatches ferries to individual partitions and local controllers that coordinate the search for nodes within each partition. Formulating the global and the local control as Partially Observable Markov Decision Processes (POMDPs), we develop efficient control policies to optimize the (discounted) total throughput, which significantly improve the performance of their predetermined counterparts incases of limited prior knowledge. C1 [He, Ting; Lee, Kang-Won] IBM Res, Hawthorne, NY 10532 USA. [Swami, Ananthram] US Army, Res Lab, Adelphi, MD 20783 USA. RP He, T (reprint author), IBM Res, Hawthorne, NY 10532 USA. EM the@us.ibm.com; aswami@arl.army.mil; kangwon@us.ibm.com NR 14 TC 0 Z9 0 U1 0 U2 0 PU ASSOC COMPUTING MACHINERY PI NEW YORK PA 1515 BROADWAY, NEW YORK, NY 10036-9998 USA BN 978-1-4503-0722-2 PY 2011 DI 10.1145/2107502.2107525 PG 10 WC Telecommunications SC Telecommunications GA BA5NG UT WOS:000336836800017 ER PT S AU Petney, TN Robbins, RG Guglielmone, AA Apanaskevich, DA Estrada-Pena, A Horak, IG Shao, RF AF Petney, Trevor N. Robbins, Richard G. Guglielmone, Alberto A. Apanaskevich, Dmitry A. Estrada-Pena, Agustin Horak, Ivan G. Shao, Renfu BE Mehlhorn, H TI A Look at the World of Ticks SO PROGRESS IN PARASITOLOGY SE Parasitology Research Monograph LA English DT Article; Book Chapter ID CRETACEOUS BURMESE AMBER; IXODES-SCAPULARIS ACARI; BIOLOGICAL-CONTROL; NORTHERN SPAIN; RICINUS ACARI; IXODIDAE; ABUNDANCE; GERMANY; LANDSCAPE; PARALYSIS C1 [Petney, Trevor N.] Karlsruhe Inst Technol, Dept Ecol & Parasitol, D-76131 Karlsruhe, Germany. [Robbins, Richard G.] Walter Reed Army Med Ctr, ISD AFPMB, Washington, DC 20307 USA. [Guglielmone, Alberto A.] Inst Nacl Tecnol Agr, Estn Expt Agr Rafaela, RA-2300 Rafaela, Argentina. [Apanaskevich, Dmitry A.] Georgia So Univ, Inst Arthropodol & Parasitol, US Natl Tick Collect, Statesboro, GA 30460 USA. [Estrada-Pena, Agustin] Univ Zaragoza, Fac Vet, Dept Parasitol, E-50013 Zaragoza, Spain. [Horak, Ivan G.] Univ Pretoria, Fac Vet Sci, Dept Vet Trop Dis, ZA-0110 Onderstepoort, Pretoria, South Africa. [Shao, Renfu] Univ Queensland, Sch Chem & Mol Biosci, Parasitol Sect, Brisbane, Qld 4072, Australia. RP Petney, TN (reprint author), Karlsruhe Inst Technol, Dept Ecol & Parasitol, Kornblumenstr 13, D-76131 Karlsruhe, Germany. EM trevor.petney@kit.edu NR 68 TC 3 Z9 4 U1 0 U2 5 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 2192-3671 BN 978-3-642-21395-3 J9 PARASITOL RES MG PY 2011 VL 2 BP 283 EP 296 DI 10.1007/978-3-642-21396-0_15 D2 10.1007/978-3-642-21396-0 PG 14 WC Parasitology SC Parasitology GA BWN01 UT WOS:000294270400015 ER PT S AU Meyers, RE Deacon, K Tunick, A AF Meyers, Ronald E. Deacon, Keith Tunick, Arnold BE Meyers, RE Shih, Y Deacon, KS TI Turbulence Measurement and Characterization for Quantum Ghost Imaging SO QUANTUM COMMUNICATIONS AND QUANTUM IMAGING IX SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Quantum Communications and Quantum Imaging IX CY AUG 24-25, 2011 CL San Diego, CA SP SPIE AB Atmospheric turbulence creates index of refraction variations that affect the paths of light propagation and provide a media for the quantum interference phenomena of quantum ghost imaging. The usual techniques for characterization of conventional optical turbulence are not generally sufficient for characterization of the effects of turbulence on quantum ghost imaging. In this paper we explore improved measurement and characterization of turbulence for improved analysis of quantum ghost imaging experiments including Turbulence-Free Ghost Imaging experiments.(1-3) C1 [Meyers, Ronald E.; Deacon, Keith; Tunick, Arnold] USA, Res Lab, Adelphi, MD 20783 USA. RP Meyers, RE (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ronald.e.meyers6.civ@mail.mil NR 11 TC 2 Z9 2 U1 0 U2 3 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-773-5 J9 PROC SPIE PY 2011 VL 8163 AR 816313 DI 10.1117/12.898965 PG 4 WC Optics; Physics, Applied SC Optics; Physics GA BXZ20 UT WOS:000297671600027 ER PT S AU Meyers, RE Deacon, KS Tunick, AD AF Meyers, Ronald E. Deacon, Keith S. Tunick, Arnold D. BE Meyers, RE Shih, Y Deacon, KS TI Turbulence-free Quantum Ghost Imaging Experiments and Results SO QUANTUM COMMUNICATIONS AND QUANTUM IMAGING IX SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Quantum Communications and Quantum Imaging IX CY AUG 24-25, 2011 CL San Diego, CA SP SPIE AB Turbulence is a serious problem for long distance imaging such as from satellites or ground based telescopes. In this paper we discuss our turbulence-free ghost imaging(1) approach that is virtually free from the degrading effects of turbulence. We discuss motivation for the experiments, theory, experimental setup, procedures, and results. The results suggest that thermal two-photon interference may not only be used to improve imaging through turbulence but may also lead to a resource for quantum information processing. C1 [Meyers, Ronald E.; Deacon, Keith S.; Tunick, Arnold D.] USA, Res Lab, Adelphi, MD 20783 USA. RP Meyers, RE (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ronald.e.meyers6.civ@mail.mil NR 18 TC 3 Z9 3 U1 1 U2 4 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-773-5 J9 PROC SPIE PY 2011 VL 8163 AR 816304 DI 10.1117/12.898966 PG 8 WC Optics; Physics, Applied SC Optics; Physics GA BXZ20 UT WOS:000297671600003 ER PT S AU Peng, W Zhang, ZY Gogos, G Gazonas, G AF Peng, W. Zhang, Z. Y. Gogos, G. Gazonas, G. BE Li, J Fu, S TI Interactions between Blast Waves and V-Shaped and Cone-Shaped Structures SO RECENT PROGRESSES IN FLUID DYNAMICS RESEARCH - PROCEEDINGS OF THE SIXTH INTERNATIONAL CONFERENCE ON FLUID MECHANICS SE AIP Conference Proceedings LA English DT Proceedings Paper CT 6th International Conference on Fluid Mechanics CY JUN 30-JUL 03, 2011 CL Guangzhou, PEOPLES R CHINA SP Chinese Soc Theoret & Appl Mech (CSTAM), Sun Yat-Sen Univ (SYSU), Gesellschaft Angewandte Mathematik & Mechanik (GAMM), U S Natl Comm Biomech (NCB US), Engn Mech Inst/ASCE (EMI/ASCE), Appl Mech Div/ASME (AMD/ASME), Japan Soc Mech Engn (JSME), Japan Soc Fluid Mech (JSFM), Int Assoc Hydraul Res (IAHR), K C Wong Educ Fdn, Natl Nat Sci Fdn China, Inst Mech, Chinese Acad Sci (IMECH CAS), Hong Kong Soc Theoret & Appl Mech (HKSTAM), Guangdong Soc Theoret & Appl Mech (GDSTAM), S China Univ Technol (SCUT), S China Sea Inst Oceanol, Chinese Acad Sci (SCSIOCAS), Guangzhou Inst Energy Convers, Chinese Acad Sci (GZIECCAS) DE oblique reflection; Mach stem reflection; incident angle; fluid-structure interaction; blast wave mitigation AB A 2-D numerical model of interactions between a blast wave and a V-shaped or a cone-shaped structure is developed. The model simulates the blast wave reflection from a V-shaped or a cone-shaped structure, the movement of the structure due to the blast impact and the induced shock wave behind the structure. Elliptic grid generation and coordinate transformation are utilized to solve the flow fields in the irregular physical domain. Different types of blast wave reflections, such as normal reflection, oblique reflection and Mach stem reflection, are captured by the numerical model. It is found that the reflected pressure and impulse transmitted to the structure decrease with the increase of incident angle. On the other hand, with the increase of incident angle, the effects of fluid structure interactions (FSI) in reducing the blast loads decreases. The FSI coupled with oblique or Mach stem reflection improves the blast wave mitigation. C1 [Peng, W.] GuangZhou Inst Energy Convers, Ocean Energy Lab, Guangzhou 510640, Guangdong, Peoples R China. [Zhang, Z. Y.; Gogos, G.] Univ Nebraska, Dept Mech Engn, Lincoln, NE 68588 USA. [Gazonas, G.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Peng, W (reprint author), GuangZhou Inst Energy Convers, Ocean Energy Lab, Guangzhou 510640, Guangdong, Peoples R China. EM pengwen@ms.giec.ac.cn FU Army Research Office [W911NF-04-2-0011]; [GHME2010GC01]; [GHME2010ZC06] FX Financial support for this study by Army Research Office Contract W911NF-04-2-0011 and Special Grand for Ocean Energy of China (GHME2010GC01, GHME2010ZC06) is gratefully acknowledged. NR 3 TC 0 Z9 0 U1 0 U2 2 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-0936-1 J9 AIP CONF PROC PY 2011 VL 1376 PG 5 WC Mechanics SC Mechanics GA BZM71 UT WOS:000302054700037 ER PT J AU Shear, DA Tate, CC Tate, MC Archer, DR LaPlaca, MC Stein, DG Dunbar, GL AF Shear, Deborah A. Tate, Ciara C. Tate, Matthew C. Archer, David R. LaPlaca, Michelle C. Stein, Donald G. Dunbar, Gary L. TI Stem cell survival and functional outcome after traumatic brain injury is dependent on transplant timing and location SO RESTORATIVE NEUROLOGY AND NEUROSCIENCE LA English DT Article DE Neural stem cells; traumatic brain injury; motor recovery; spatial learning and memory; stem cell survival and migration; CNS repair ID CHONDROITIN SULFATE PROTEOGLYCAN; SPINAL-CORD-INJURY; NG2-POSITIVE CELLS; OLIGODENDROCYTE PROGENITORS; ADULT RATS; NG2; RECOVERY; DEFICITS; MODEL; MOTOR AB Purpose: Recent work indicates that transplanted neural stem cells (NSCs) can survive, migrate to the injury site, and facilitate recovery from traumatic brain injury (TBI). The present study manipulated timing and location of NSC transplants following controlled cortical impact injury (CCI) in mice to determine optimal transplant conditions. Methods: In Experiment 1 (timing), NSCs (E14.5 mouse) were injected into the host striatum, ipsilateral to the injury, at 2, 7, or 14 days. In Experiment 2 (location), NSCs or vehicle were injected into the mouse striatum (7 days post-CCI) either ipsilateral or contralateral to the injury and cognitive and motor abilities were assessed from weeks 1-8 post-transplant. Histological measures of NSC survival, migration, and differentiation were taken at 6 and 8 weeks post-transplant. Results: The results demonstrate that: (1) 2-7 days post-injury is the optimal time-range for delivering NSCs; (2) time of transplantation does not affect short-term phenotypic differentiation; (3) transplant location affects survival, migration, phenotype, and functional efficacy; and (4) NSC-mediated functional recovery is not contingent upon NSC migration or phenotypic differentiation. Conclusions: These findings provide further support for the idea that mechanisms other than the replacement of damaged neurons or glia, such as NSC-induced increases in protective neurotrophic factors, may be responsible for the functional recovery observed in this model of TBI. C1 [Shear, Deborah A.; Stein, Donald G.] Emory Univ, Dept Emergency Med, Atlanta, GA 30322 USA. [Tate, Ciara C.; LaPlaca, Michelle C.] Emory Univ, Dept Biomed Engn, Georgia Inst Technol, Atlanta, GA 30322 USA. [Tate, Matthew C.] Emory Univ, Sch Med, Atlanta, GA USA. [Archer, David R.] Emory Univ, Dept Pediat, Atlanta, GA 30322 USA. [Stein, Donald G.] Emory Univ, Dept Neurol, Atlanta, GA 30322 USA. [Shear, Deborah A.; Dunbar, Gary L.] Field Neurosci Inst, Saginaw, MI USA. [Shear, Deborah A.; Dunbar, Gary L.] Cent Michigan Univ, Dept Psychol, Neurosci Program, Mt Pleasant, MI 48859 USA. RP Shear, DA (reprint author), Walter Reed Army Inst Res, MRMC UWI C, Bldng 503-2 W14, Silver Spring, MD 20910 USA. EM Deborah.Shear@AMEDD.ARMY.MIL RI Shear, Deborah/B-3607-2011 FU John G. Kulhavi Professorship FX This work was supported by a generous research gift from Field Neurosciences Institute, Saginaw MI (to DGS) and a John G. Kulhavi Professorship (to GLD). NR 24 TC 24 Z9 30 U1 0 U2 7 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 0922-6028 J9 RESTOR NEUROL NEUROS JI Restor. Neurol. Neurosci. PY 2011 VL 29 IS 4 BP 215 EP 225 DI 10.3233/RNN-2011-0593 PG 11 WC Neurosciences SC Neurosciences & Neurology GA 814VR UT WOS:000294485800001 PM 21697596 ER PT S AU Brennan, RE Green, WH AF Brennan, R. E. Green, W. H. BE Thompson, DO Chimenti, DE TI LOW VELOCITY IMPACT TESTING AND NONDESTRUCTIVE EVALUATION OF TRANSPARENT MATERIALS SO REVIEW OF PROGRESS IN QUANTITATIVE NONDESTRUCTIVE EVALUATION, VOLS 30A AND 30B SE AIP Conference Proceedings LA English DT Proceedings Paper CT 37th Annual Review of Progress in Quantitative Nondestructive Evaluation (QNDE) CY JUL 18-23, 2010 CL San Diego, CA SP Iowa State Univ, Ctr Nondestruct Evaluat, QNDE DE Nondestructive Evaluation; Ultrasound; Digital Radiography; Imaging; Impact Damage AB Advanced transparent materials are used in protective systems for enhancing the survivability of ground vehicles, air vehicles, and personnel in applications such as face shields, riot gear, and vehicle windows. Low velocity impact damage can limit visibility and compromise the structural integrity of a transparent system, increasing the likelihood of further damage or penetration from a high velocity impact strike. For this reason, it is critical to determine damage tolerance levels of transparent systems to indicate whether or not a component should be replaced. In this study, transparent laminate systems will be tested by comparing baseline conditions to experimentally controlled damage states. Destructive testing including air gun and sphere impact testing will be used to replicate low velocity impacts in the field. Characterization of the damaged state will include basic visual inspection as well as nondestructive techniques including cross-polarization, x-ray, and ultrasound. The combination of destructive testing and characterization of the resulting damage can help to establish a damage acceptance criterion for materials used in protective systems. C1 [Brennan, R. E.; Green, W. H.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Brennan, RE (reprint author), USA, Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. NR 8 TC 0 Z9 0 U1 1 U2 2 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-0888-3 J9 AIP CONF PROC PY 2011 VL 1335 BP 965 EP 972 DI 10.1063/1.3592042 PG 8 WC Physics, Applied SC Physics GA BYH04 UT WOS:000298674300117 ER PT S AU Green, WH Brennan, RE AF Green, W. H. Brennan, R. E. BE Thompson, DO Chimenti, DE TI NONDESTRUCTIVE CHARACTERIZATION OF AS-FABRICATED COMPOSITE CERAMIC PANELS SO REVIEW OF PROGRESS IN QUANTITATIVE NONDESTRUCTIVE EVALUATION, VOLS 30A AND 30B SE AIP Conference Proceedings LA English DT Proceedings Paper CT 37th Annual Review of Progress in Quantitative Nondestructive Evaluation (QNDE) CY JUL 18-23, 2010 CL San Diego, CA SP Iowa State Univ, Ctr Nondestruct Evaluat, QNDE DE X-ray Computed Tomography; Ultrasonic Testing; Protective System; Nondestructive Evaluation; Ceramics; Confinement; Fabrication Flaws AB Decreasing the weight of protective systems, while minimizing the decrease in ballistic performance, is an ongoing goal of the Army. Ceramic materials are currently combined with other materials in these types of structures in order to decrease weight without losing ballistic performance. This includes structures in which the ceramic material is confined in some way and in which the ceramic material is completely encapsulated. Confinement or encapsulation of ceramic material within a structure generally adds complexity and cost. Relatively simple panel specimens fabricated with ceramic tiles on aluminum backings and side confinement using steel were evaluated using nondestructive methods, including x-ray computed tomography and ultrasonic testing. The nondestructive evaluation results will be discussed and compared, including the detectability and mapping of fabrication features. C1 [Green, W. H.; Brennan, R. E.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Green, WH (reprint author), USA, Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. NR 6 TC 0 Z9 0 U1 0 U2 1 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-0888-3 J9 AIP CONF PROC PY 2011 VL 1335 BP 989 EP 996 DI 10.1063/1.3592045 PG 8 WC Physics, Applied SC Physics GA BYH04 UT WOS:000298674300120 ER PT S AU Sandhu, JS Pergantis, CG AF Sandhu, Jaswinder S. Pergantis, Charles G. BE Thompson, DO Chimenti, DE TI NDE OF HYBRID ARMOR STRUCTURES USING ACOUSTOGRAPHY SO REVIEW OF PROGRESS IN QUANTITATIVE NONDESTRUCTIVE EVALUATION, VOLS 30A AND 30B SE AIP Conference Proceedings LA English DT Proceedings Paper CT 37th Annual Review of Progress in Quantitative Nondestructive Evaluation (QNDE) CY JUL 18-23, 2010 CL San Diego, CA SP Iowa State Univ, Ctr Nondestruct Evaluat, QNDE DE Ultrasonic Testing; Nondestructive Testing AB The US Army is investigating the use of composite materials to deliver lightweight and more effective armor protection systems to soldiers and other army assets. However, widespread use of such hybrid armor will require a reliable but fast NDE methodology to ensure integrity of these components during manufacturing and while in service. Traditional ultrasonic inspection of such hybrid armor structures may prove to be very effective, but point-by-point ultrasonic scanning is inherently time-consuming and manufacturing slowdowns could develop in high-volume production of such armor systems. In this paper, we report on the application of acoustography for the NDE of hybrid armor structures. Acoustography differs from conventional ultrasonic testing in that test objects are inspected in full field, analogously to real time x-ray imaging. The approach uses a novel, super high resolution large area acousto-optic (AO) sensor, which allows image formation through simple ultrasound shadow casting, analogous to x-ray image formation. This NDE approach offers significant inspection speed advantage over conventional point-by-point ultrasonic scanning procedures and is well-suited for high volume production. We will report initial results on a number of hybrid armor plate specimens employing composite materials that are being investigated by the US Army. Acoustography NDE results will also be verified using other complimentary NDE methods. C1 [Sandhu, Jaswinder S.] Santec Syst Inc, 716 S Milwaukee Ave, Wheeling, IL USA. [Pergantis, Charles G.] U S Army Res Lab, Aberdeen Proving Ground, MD 20783 USA. RP Sandhu, JS (reprint author), Santec Syst Inc, 716 S Milwaukee Ave, Wheeling, IL USA. FU US Army [W911QX-04-C-0030] FX This material is based upon work supported in part by the US Army, under contract number W911QX-04-C-0030. The authors are also grateful to the Alloyweld Inspection Co, Inc. for assistance in generating the complementary digital x-ray and c-scan data on the specimens. NR 3 TC 0 Z9 0 U1 0 U2 2 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-0888-3 J9 AIP CONF PROC PY 2011 VL 1335 BP 1005 EP 1012 DI 10.1063/1.3592047 PG 8 WC Physics, Applied SC Physics GA BYH04 UT WOS:000298674300122 ER PT S AU Schmidt, KF Little, JR Ellingson, WA Meitzler, TJ Green, W AF Schmidt, Karl F. Little, Jack R. Ellingson, William A. Meitzler, Thomas J. Green, William BE Thompson, DO Chimenti, DE TI MINIATURIZED HAND HELD MICROWAVE INTERFERENCE SCANNING SYSTEM FOR NDE OF DIELECTRIC ARMOR AND ARMOR SYSTEMS SO REVIEW OF PROGRESS IN QUANTITATIVE NONDESTRUCTIVE EVALUATION, VOLS 30A AND 30B SE AIP Conference Proceedings LA English DT Proceedings Paper CT 37th Annual Review of Progress in Quantitative Nondestructive Evaluation (QNDE) CY JUL 18-23, 2010 CL San Diego, CA SP Iowa State Univ, Ctr Nondestruct Evaluat, QNDE DE Microwave; NDT; Ceramics; Composites; Armor AB Inspection of ceramic-based armor has advanced through development of a microwave-based, portable. non-contact NDE system. Recently, this system was miniaturized and made wireless for maximum utility in field applications. The electronic components and functionality of the laboratory system are retained, with alternative means of position input for creation of scan images. Validation of the detection capability was recently demonstrated using specially fabricated surrogates and ballistic impact-damaged specimens. The microwave data results have been compared to data from laboratory-based microwave interferometry systems and digital x-ray imaging. The microwave interference scanning has been shown to reliably detect cracks, laminar features and material property variations. The authors present details of the system operation, descriptions of the test samples used and recent results obtained. C1 [Schmidt, Karl F.; Little, Jack R.] Evisive Inc, Baton Rouge, LA USA. [Ellingson, William A.] Argonne Natl Lab, Argonne, IL 60439 USA. [Meitzler, Thomas J.] US Army Res Dev Command Tank Automot Res, Dev & Eng Ctr, Warren, MI 39180 USA. [Green, William] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Schmidt, KF (reprint author), Evisive Inc, Baton Rouge, LA USA. RI Meitzler, Thomas/D-1065-2017 FU US Army Tank-Automative Research, Development and Engineering Center (TARDEC); US Army Research Laboratory; US Air Force Research Laboratory FX Worl included in the report is supported by the US Army Tank-Automative Research, Development and Engineering Center (TARDEC), US Army Research Laboratory and US Air Force Research Laboratory. Evisive would also like to acknowledge project participation and support by Argonne National Laboratory. NR 10 TC 0 Z9 0 U1 0 U2 0 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-0888-3 J9 AIP CONF PROC PY 2011 VL 1335 BP 1021 EP 1028 DI 10.1063/1.3592049 PG 8 WC Physics, Applied SC Physics GA BYH04 UT WOS:000298674300124 ER PT J AU Artemenko, AG Muratov, EN Kuz'min, VE Muratov, NN Varlamova, EV Kuz'mina, AV Gorb, LG Golius, A Hill, FC Leszczynski, J Tropsha, A AF Artemenko, A. G. Muratov, E. N. Kuz'min, V. E. Muratov, N. N. Varlamova, E. V. Kuz'mina, A. V. Gorb, L. G. Golius, A. Hill, F. C. Leszczynski, J. Tropsha, A. TI QSAR analysis of the toxicity of nitroaromatics in Tetrahymena pyriformis: structural factors and possible modes of action SO SAR AND QSAR IN ENVIRONMENTAL RESEARCH LA English DT Article DE Tetrahymena pyriformis; QSAR; chemical toxicants; prediction of toxicity ID QUANTITATIVE STRUCTURE; SIMPLEX REPRESENTATION; MOLECULAR-STRUCTURE; VARIABLE SELECTION; NITROBENZENE TOXICITY; APPLICABILITY DOMAIN; POLAR NARCOSIS; PLS; VALIDATION; DERIVATIVES AB The Hierarchical Technology for Quantitative Structure-Activity Relationships (HiT QSAR) was applied to 95 diverse nitroaromatic compounds (including some widely known explosives) tested for their toxicity (50% inhibition growth concentration, IGC(50)) against the ciliate Tetrahymena pyriformis. The dataset was divided into subsets according to putative mechanisms of toxicity. The Classification and Regression Trees (CART) approach implemented within HiT QSAR has been used for prediction of mechanism of toxicity for new compounds. The resulting models were shown to have similar to 80% accuracy for external datasets indicating that the mechanistic dataset division was sensible. The Partial Least Squares (PLS) statistical approach was then used to develop 2D QSAR models. Validated PLS models were explored to: (1) elucidate the effects of different substituents in nitroaromatic compounds on toxicity; (2) differentiate compounds by probable mechanisms of toxicity based on their structural descriptors; and (3) analyse the role of various physical-chemical factors responsible for compounds' toxicity. Models were interpreted in terms of molecular fragments promoting or interfering with toxicity. It was also shown that mutual influence of substituents in benzene ring plays the determining role in toxicity variation. Although chemical mechanism based models were statistically significant and externally predictive (r(ext)(2) = 0.64 for the external set of 63 nitroaromatics identified after all calculations have been completed), they were also shown to have limited coverage (57% for modelling and 76% for external set). C1 [Artemenko, A. G.; Muratov, E. N.; Kuz'min, V. E.; Leszczynski, J.] Jackson State Univ, Interdisciplinary Nanotox Ctr, Jackson, MS USA. [Artemenko, A. G.; Muratov, E. N.; Kuz'min, V. E.; Varlamova, E. V.] Natl Acad Sci Ukraine, AV Bogatsky Phys Chem Inst, Odessa, Ukraine. [Muratov, E. N.; Tropsha, A.] Univ N Carolina, Sch Pharm, Div Med Chem & Nat Prod, Chapel Hill, NC 27599 USA. [Muratov, N. N.] Odessa Natl Polytech Univ, Odessa, Ukraine. [Kuz'mina, A. V.] Odessa Natl Med Univ, Odessa, Ukraine. [Gorb, L. G.] Badger Tech Serv LLC, Vicksburg, MS USA. [Golius, A.] Kharkiv Natl VN Karazin Univ, Dept Radiophys, Karkiv, Ukraine. [Hill, F. C.] US Army ERDC, Vicksburg, MS USA. RP Leszczynski, J (reprint author), Jackson State Univ, Interdisciplinary Nanotox Ctr, Jackson, MS USA. EM jerzy@icnanotox.org; alex_tropsha@unc.edu RI Muratov, Eugene/C-4454-2014; Tropsha, Alexander/G-6245-2014 OI Muratov, Eugene/0000-0003-4616-7036; FU NIH [R21GM076059, GM66940]; United States Army Corps of Engineers by the USAERDC FX The use of trade, product, or company names in this report is for descriptive purposes only and does not imply endorsement by the U.S. Government. Results in this study were funded and obtained from research conducted under the Environmental Quality Technology Program of the United States Army Corps of Engineers by the USAERDC. Permission was granted by the Chief of Engineers to publish this information. The findings of this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. A.T. acknowledges the support from the NIH grants R21GM076059 and GM66940. NR 60 TC 20 Z9 20 U1 0 U2 21 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1062-936X J9 SAR QSAR ENVIRON RES JI SAR QSAR Environ. Res. PY 2011 VL 22 IS 5-6 BP 575 EP 601 DI 10.1080/1062936X.2011.569950 PG 27 WC Chemistry, Multidisciplinary; Computer Science, Interdisciplinary Applications; Environmental Sciences; Mathematical & Computational Biology; Toxicology SC Chemistry; Computer Science; Environmental Sciences & Ecology; Mathematical & Computational Biology; Toxicology GA 882JT UT WOS:000299560600009 PM 21714735 ER PT J AU Foley, DC Al-Maharbi, M Hartwig, KT Karaman, I Kecskes, LJ Mathaudhu, SN AF Foley, D. C. Al-Maharbi, M. Hartwig, K. T. Karaman, I. Kecskes, L. J. Mathaudhu, S. N. TI Grain refinement vs. crystallographic texture: Mechanical anisotropy in a magnesium alloy SO SCRIPTA MATERIALIA LA English DT Article DE Equal channel angular extrusion/pressing; Magnesium alloys; Ultrafine-grained materials; Anisotropy; Crystallographic texture ID CHANNEL ANGULAR EXTRUSION; SEVERE PLASTIC-DEFORMATION; ZN ALLOY; EVOLUTION; STRENGTH; MICROSTRUCTURE; DUCTILITY; AZ31B; TWINS; ECAE AB A magnesium alloy was subjected to severe plastic deformation via an unconventional equal channel angular extrusion route at decreasing temperatures. This method facilitates incremental grain refinement and enhances formability by activating dynamic recrystallization in the initial steps and suppressing deformation twinning. Compression experiments in three orthogonal directions demonstrated high strength levels in the processed sample, up to 350 MPa in yield and 500 MPa in ultimate strengths. Notable flow stress anisotropy is correlated with the processing texture and microstructure. (C) 2010 Published by Elsevier Ltd. on behalf of Acta Materialia Inc. C1 [Foley, D. C.; Al-Maharbi, M.; Hartwig, K. T.; Karaman, I.] Texas A&M Univ, Mat Sci & Engn Program, College Stn, TX 77843 USA. [Hartwig, K. T.; Karaman, I.] Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. [Kecskes, L. J.; Mathaudhu, S. N.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, Aberdeen Proving Ground, MD 21005 USA. RP Hartwig, KT (reprint author), Texas A&M Univ, Mat Sci & Engn Program, College Stn, TX 77843 USA. EM thartwig@tamu.edu RI Mathaudhu, Suveen/B-4192-2009; Karaman, Ibrahim/E-7450-2010; Foley, David/A-5414-2012; Kecskes, Laszlo/F-6880-2014 OI Karaman, Ibrahim/0000-0001-6461-4958; Kecskes, Laszlo/0000-0002-1342-3729 FU US Army Research Laboratory [W911QX-08-P-0640] FX This work was funded by the US Army Research Laboratory through contract W911QX-08-P-0640. The authors acknowledge the important assistance of R. Barber and D. Krebs for ECAE processing. NR 22 TC 36 Z9 37 U1 4 U2 30 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6462 J9 SCRIPTA MATER JI Scr. Mater. PD JAN PY 2011 VL 64 IS 2 BP 193 EP 196 DI 10.1016/j.scriptamat.2010.09.042 PG 4 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 687YW UT WOS:000284815500023 ER PT J AU Mena, E Choyke, P Tan, E Landgren, O Kurdziel, K AF Mena, Esther Choyke, Peter Tan, Esther Landgren, Ola Kurdziel, Karen TI Molecular Imaging in Myeloma Precursor Disease SO SEMINARS IN HEMATOLOGY LA English DT Article ID ASYMPTOMATIC MULTIPLE-MYELOMA; WHOLE-BODY MRI; UNDETERMINED SIGNIFICANCE MGUS; POSITRON-EMISSION-TOMOGRAPHY; CLINICAL STAGING SYSTEM; MONOCLONAL GAMMOPATHY; BONE-SCINTIGRAPHY; PET; CANCER; RADIOGRAPHY AB Multiple myeloma (MM) is consistently preceded by its pre-malignant states, monoclonal gammopathy of undetermined significance (MGUS) and/or smoldering multiple myeloma (SMM). By definition, precursor conditions do not exhibit end-organ disease (anemia, hypercalcemia, renal failure, skeletal lytic lesions, or a combination of these). However, new imaging methods are demonstrating that some patients in the MGUS or SMM category are exhibiting early signs of MM. Although MGUS/SMM patients are currently defined as low-risk versus high-risk based on clinical markers, we currently lack the ability to predict the individual patient's risk of progression from MGUS/SMM to MM. Given that the presence of gross lytic bone lesions is a hallmark of MM, it is reasonable to believe that less severe bone changes defined by more sensitive imaging may be predictive of MM progression. Indeed, since bone disease is such an essential aspect of MM, imaging techniques directed at the detection of early bone lesions, have the potential to become increasingly more useful in the setting of MGUS/SMM. Current guidelines for the radiological assessment of MM still recommend the traditional skeletal survey, although its limitations are well documented, especially in early phases of the disease when radiographs can significantly underestimate the extent of bone lesions and bone marrow involvement. Newer, more advanced imaging modalities, with higher sensitivities, including whole-body low-dose computed tomography (CI), magnetic resonance imaging (MRI), and positron emission tomography (PET) are being employed. Also various imaging techniques have been used to provide an assessment of bone involvement and identify extra-osseous disease. This review emphasizes the current state of the art and emerging imaging methods, which may help to better define high-risk versus low-risk MGUS/SMM. Ultimately, improved imaging could allow more tailored clinical management, and, most likely play an important role in the development of future treatment strategies for high-risk precursor disease. Semin Hematol 48:22-31. Published by Elsevier Inc. C1 [Mena, Esther; Choyke, Peter; Kurdziel, Karen] NCI, Mol Imaging Program, NIH, Bethesda, MD 20892 USA. [Tan, Esther] Walter Reed Army Med Ctr, Dept Med, Hematol Oncol Serv, Washington, DC 20307 USA. [Tan, Esther; Landgren, Ola] NCI, Med Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. RP Choyke, P (reprint author), 10 Ctr Dr,Bldg 10,Room B3B69F, Bethesda, MD 20892 USA. EM pchoyke@mail.nih.gov FU Intramural NIH HHS [Z01 BC010714-02] NR 54 TC 11 Z9 11 U1 0 U2 2 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0037-1963 J9 SEMIN HEMATOL JI Semin. Hematol. PD JAN PY 2011 VL 48 IS 1 BP 22 EP 31 DI 10.1053/j.seminhematol.2010.11.006 PG 10 WC Hematology SC Hematology GA 709AA UT WOS:000286406100004 PM 21232655 ER PT J AU Minter, AR Simpson, H Weiss, BM Landgren, O AF Minter, Alex R. Simpson, Haley Weiss, Brendan M. Landgren, Ola TI Bone Disease From Monoclonal Gammopathy of Undetermined Significance to Multiple Myeloma: Pathogenesis, Interventions, and Future Opportunities SO SEMINARS IN HEMATOLOGY LA English DT Article ID CARBOXY-TERMINAL TELOPEPTIDE; MARROW STROMAL CELLS; OSTEOLYTIC LESIONS; SERUM-LEVELS; I COLLAGEN; OSTEOBLAST DIFFERENTIATION; VERTEBRAL FRACTURES; RECEPTOR ACTIVATOR; UNTREATED MYELOMA; TUMOR PROGRESSION AB Manifestations of bone disease-osteopenia, osteolytic lesions, and fractures are the hallmark of multiple myeloma (MM) and occur clinically in the vast majority of patients. These abnormalities can have devastating clinical effects by increasing both the morbidity and mortality of patients. Bone disease is usually found when patients are diagnosed with active MM; however, recent data suggest that it is present in early myelomagenesis, including patients with myeloma precursor disease, monoclonal gammopathy of undetermined significance (MGUS). The primary mechanisms of abnormal bone remodeling are increased osteoclastic activity, which occurs in close proximity to active myeloma cells, and decreased activity of the surrounding osteoblasts. Better understanding of the pathogenesis of bone disease in MM will allow us to enhance our current therapeutic options in the treatment of bone disease. In patients with active MM and at least one lytic lesion, intravenous bisphosphonates have been shown to decrease skeletal-related events and pain, improve performance status, and maintain quality of life. Emerging evidence suggests that intervention at earlier stages of disease may prevent skeletal-related events at time of progression, but there is no evidence that bisphosphonates in this setting change the natural history of the disease. Semin Hematol 48:55-65. Published by Elsevier Inc. C1 [Minter, Alex R.; Weiss, Brendan M.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Minter, Alex R.; Simpson, Haley; Weiss, Brendan M.; Landgren, Ola] NCI, Med Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. RP Minter, AR (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. EM alex.minter@med.navy.mil; landgreo@mail.nih.gov NR 73 TC 11 Z9 11 U1 0 U2 5 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0037-1963 J9 SEMIN HEMATOL JI Semin. Hematol. PD JAN PY 2011 VL 48 IS 1 BP 55 EP 65 DI 10.1053/j.seminhematol.2010.11.001 PG 11 WC Hematology SC Hematology GA 709AA UT WOS:000286406100008 PM 21232659 ER PT J AU Weinstein, SA Stiles, BG AF Weinstein, Scott A. Stiles, Bradley G. TI A review of the epidemiology, diagnosis and evidence-based management of Mycoplasma genitalium SO SEXUAL HEALTH LA English DT Review DE azithromycin; cervicitis; prevalence; urethritis ID PELVIC-INFLAMMATORY-DISEASE; REAL-TIME PCR; TRANSCRIPTION-MEDIATED AMPLIFICATION; SEXUALLY-TRANSMITTED INFECTION; POLYMERASE-CHAIN-REACTION; FEMALE SEX WORKERS; NONGONOCOCCAL URETHRITIS; CHLAMYDIA-TRACHOMATIS; NEISSERIA-GONORRHOEAE; GENITOURINARY MEDICINE AB Mycoplasma genitalium is attracting increasing recognition as an important sexually transmitted pathogen. Presented is a review of the epidemiology, detection, presentation and management of M. genitalium infection. Accumulating evidence suggests that M. genitalium is an important cause of non-gonococcal, non-chlamydial urethritis and cervicitis, and is linked with pelvic inflammatory disease and, possibly, obstetric complications. Although there is no standard detection assay, several nucleic acid amplification tests have >95% sensitivity and specificity for M. genitalium. To date, there is a general lack of established protocols for screening in public health clinics. Patients with urethritis or cervicitis should be screened for M. genitalium and some asymptomatic sub-groups should be screened depending on individual factors and local prevalence. Investigations estimating M. genitalium geographic prevalence document generally low incidence, but some communities exhibit infection frequencies comparable to that of Chlamydia trachomatis. Accumulating evidence supports an extended regimen of azithromycin for treatment of M. genitalium infection, as data suggest that stat 1 g azithromycin may be less effective. Although data are limited, azithromycin-resistant cases documented to date respond to an appropriate fluoroquinolone (e.g. moxifloxacin). Inconsistent clinical recognition of M. genitalium may result in treatment failure and subsequent persistence due to ineffective antibiotics. The contrasting nature of existing literature regarding risks of M. genitalium infection emphasises the need for further carefully controlled studies of this emerging pathogen. C1 [Weinstein, Scott A.] Womens & Childrens Hosp, Adelaide, SA 5003, Australia. [Stiles, Bradley G.] USA, Med Res Inst Infect Dis, Dept Immunol & Mol Biol, Frederick, MD 21702 USA. [Stiles, Bradley G.] Wilson Coll, Dept Biol, Chambersburg, PA 17201 USA. RP Weinstein, SA (reprint author), Womens & Childrens Hosp, 72 King William Rd, Adelaide, SA 5003, Australia. EM herptoxmed@msn.com NR 136 TC 17 Z9 19 U1 0 U2 3 PU CSIRO PUBLISHING PI CLAYTON PA UNIPARK, BLDG 1, LEVEL 1, 195 WELLINGTON RD, LOCKED BAG 10, CLAYTON, VIC 3168, AUSTRALIA SN 1448-5028 EI 1449-8987 J9 SEX HEALTH JI Sex Health PY 2011 VL 8 IS 2 BP 143 EP 158 DI 10.1071/SH10065 PG 16 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 766HL UT WOS:000290771500004 PM 21592428 ER PT B AU Getchis, TL Rose, CM AF Getchis, Tessa L. Rose, Cori M. BE Shumway, SE TI Balancing economic development and conservation of living marine resources and habitats: the role of resource managers SO SHELLFISH AQUACULTURE AND THE ENVIRONMENT LA English DT Article; Book Chapter ID SUBMERGED AQUATIC VEGETATION; SUSPENSION-FEEDING BIVALVES; PACIFIC-NORTHWEST ESTUARY; EELGRASS ZOSTERA-MARINA; SHELLFISH AQUACULTURE; BENTHIC COMMUNITIES; MUSSEL AQUACULTURE; USA; CULTURE; OYSTER C1 [Getchis, Tessa L.] Univ Connecticut, Connecticut Sea Grant, Groton, CT 06340 USA. [Rose, Cori M.] US Army Corps Engn, New England Div, Concord, MA USA. RP Getchis, TL (reprint author), Univ Connecticut, Connecticut Sea Grant, Groton, CT 06340 USA. NR 63 TC 3 Z9 3 U1 0 U2 0 PU JOHN WILEY & SONS PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER, W SUSSEX PO 19 8SQ, ENGLAND BN 978-0-470-96093-6; 978-0-8138-1413-1 PY 2011 BP 425 EP 446 D2 10.1002/9780470960967 PG 22 WC Environmental Sciences; Fisheries SC Environmental Sciences & Ecology; Fisheries GA BA8DK UT WOS:000338008200017 ER PT J AU Mondello, S Dellarole, A Bullock, R Gabrielli, A Antonio, A Tortella, F Wang, K Hayes, R AF Mondello, S. Dellarole, A. Bullock, R. Gabrielli, A. Antonio, A. Tortella, F. Wang, K. Hayes, R. TI NEURONAL AND GLIAL MARKERS IN MICRODIALYSATE AFTER TRAUMATIC AND HYPOXEMIC BRAIN INJURY IN RATS SO SHOCK LA English DT Meeting Abstract C1 [Mondello, S.; Gabrielli, A.; Wang, K.; Hayes, R.] Univ Florida, Gainesville, FL USA. [Dellarole, A.; Bullock, R.] Univ Miami, Miami, FL USA. [Antonio, A.] Univ Messina, Messina, Italy. [Tortella, F.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Wang, K.; Hayes, R.] Banyan Biomarkers Inc, Alachua, FL USA. RI Mondello, Stefania/A-1813-2012 OI Mondello, Stefania/0000-0002-8587-3614 NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PY 2011 VL 36 SU 1 BP 25 EP 25 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 813SS UT WOS:000294389500073 ER PT S AU Won, S Young, S Seetharaman, G Palaniappan, K AF Won, Stephen Young, Susan Seetharaman, Gunasekaran Palaniappan, Kannappan BE Kadar, I TI Sub-pixel registration of moving objects in visible and thermal imagery with adaptive segmentation SO SIGNAL PROCESSING, SENSOR FUSION, AND TARGET RECOGNITION XX SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Signal Processing, Sensor Fusion, and Target Recognition XX CY APR 25-27, 2011 CL Orlando, FL SP SPIE DE adaptive variance segmentation; image registration; optical flow; video surveillance and monitoring ID OPTICAL-FLOW AB Sub-pixel registration is critical in object tracking and image super-resolution. Motion segmentation algorithms using the gradient can be applied prior to image registration to improve its accuracy and computational runtime. This paper proposes a new segmentation method that is adaptive variation segmentation in the form of local variances taken at different block sizes to be applied to the sum of absolute image differences. In this paper, two motion segmentation and four image registration methods are tested to optimize the registration accuracy in visible and thermal imagery. Two motion segmentation methods, flux tensor and adaptive variation segmentation, are quantitatively tested by comparing calculated regions of movement with accepted areas of motion. Four image registration methods, including two optical flow, feature correspondence, and correlation methods, are tested in two steps: gross shift and sub-pixel shift estimations. Gross shift estimation accuracy is assessed by comparing estimated shifts against a ground truth. Sub-pixel shift estimation accuracy is assessed by simulated, down-sampled images. Evaluations show that the best segmentation results are achieved using either the flux tensor or adaptive segmentation methods. For well-defined objects, feature correspondence and correlation registration produce the most accurate gross shift registrations. For not well-defined objects, the correlation method produces the most accurate gross and sub-pixel shift registration. C1 [Won, Stephen; Young, Susan] USA, Res Lab, Adelphi, MD 20783 USA. RP Won, S (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM stephen.won@arl.army.com NR 11 TC 0 Z9 0 U1 0 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-624-0 J9 PROC SPIE PY 2011 VL 8050 AR 80501A DI 10.1117/12.883262 PG 9 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA BVN64 UT WOS:000291978200041 ER PT S AU Habersat, D Lelis, A AF Habersat, Daniel Lelis, Aivars BE Monakhov, EV Hornos, T Svensson, BG TI Improved Observation of SiC/SiO2 Oxide Charge Traps Using MOS C-V SO SILICON CARBIDE AND RELATED MATERIALS 2010 SE Materials Science Forum LA English DT Proceedings Paper CT 8th European Conference on Silicon Carbide and Related Materials CY AUG 29-SEP 02, 2010 CL Sundvolden Conf Ctr, Oslo, NORWAY SP Aixtron, Dow Corning, Birkeland Innovation, Centrotherm, CREE Inc, Gen Elect, LPE, Norden NordForsk, SiCED, SiCrystal AG, Res Council Norway, Univ Oslo HO Sundvolden Conf Ctr DE MOS Capacitor; MOSFET; charge trapping; bias instability ID SIC MOSFETS; RELIABILITY; PERFORMANCE; DEPENDENCE AB We have used C-V techniques to study the bias instability of 4H-SiC MOS capacitors and FETs, and compared those results to those obtained using I-D-V-GS. The net "back-and-forth" instability from C-V was found to exceed that of I-D-V-GS and matched closely with values from fast I-D-V-GS and midgap extrapolation, suggesting that the C-V method is more effective at measuring a "true" instability effect than I-D-V-GS alone. Using C-V, capacitors and large-area MOSFETs showed similar instability behavior, implying that the presence of minority carriers are not necessary to observe bias instability. One-way bias-stress C-V measurements reveal that most of the bias instability occurs under negative bias stress, whereas the opposite is observed in one-way bias stress I-D-V-GS measurements. Finally, post-oxidation NO annealing reduced the Delta V-T, bias instability for positive bias stress but does not appear to have influenced any of the other conditions. C1 [Habersat, Daniel; Lelis, Aivars] USA, Res Lab, Adelphi, MD 20783 USA. RP Habersat, D (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM daniel.habersat@us.army.mil; aivars.j.lelis@us.army.mil NR 9 TC 4 Z9 4 U1 2 U2 5 PU TRANS TECH PUBLICATIONS LTD PI STAFA-ZURICH PA LAUBLSRUTISTR 24, CH-8717 STAFA-ZURICH, SWITZERLAND SN 0255-5476 J9 MATER SCI FORUM PY 2011 VL 679-680 BP 366 EP 369 DI 10.4028/www.scientific.net/MSF.679-680.366 PG 4 WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA BVJ83 UT WOS:000291673500087 ER PT S AU Veliadis, V Urciuoli, D Ha, HC Hearne, H Scozzie, C AF Veliadis, V. Urciuoli, D. Ha, H. C. Hearne, H. Scozzie, C. BE Monakhov, EV Hornos, T Svensson, BG TI 600-V symmetrical bi-directional power switching using SiC vertical-channel JFETs with reliable edge termination SO SILICON CARBIDE AND RELATED MATERIALS 2010 SE Materials Science Forum LA English DT Proceedings Paper CT 8th European Conference on Silicon Carbide and Related Materials CY AUG 29-SEP 02, 2010 CL Sundvolden Conf Ctr, Oslo, NORWAY SP Aixtron, Dow Corning, Birkeland Innovation, Centrotherm, CREE Inc, Gen Elect, LPE, Norden NordForsk, SiCED, SiCrystal AG, Res Council Norway, Univ Oslo HO Sundvolden Conf Ctr DE bi-directional; normally-ON; JFET; edge termination; guard rings; SiC AB Numerous high-voltage applications require symmetrical bi-directional power flow control and protection circuitry. While mechanical contactors and circuit breakers provide bidirectional fault protection, they have slow actuation and suffer severe degradation during repeated fault isolation. The normally-on (N-ON) SiC vertical-channel Junction-Field-Effect-Transistor (VJFET) is an efficient solution for bi-directional circuit-breaker applications due to its low conduction/switching losses, +500 degrees C operational capability, ON-state match of the no-fault operating mode of the system, efficient gate-drive operation under unipolar biasing, and majority carrier device scalability. Efficient 600-V/10-A symmetrical bi-directional power flow was demonstrated using 0.1-cm(2) 1200-V rated N-ON VJFETs with a gate driver applying 0-V and -34 V gate biases during the ON and OFF states, respectively. A self-aligned trenched guard-ring structure provides reliable edge termination. C1 [Veliadis, V.; Ha, H. C.; Hearne, H.] Northrop Grumman Elect Syst, Linthicum, MD 21090 USA. [Urciuoli, D.; Scozzie, C.] US Army Res Lab, Adelphi, MD 20783 USA. RP Veliadis, V (reprint author), Northrop Grumman Elect Syst, Linthicum, MD 21090 USA. EM victor.veliadis@ngc.com; damian.urciuoli@us.army.mil; hanh.ha@ngc.com; harold.hearne@ngc.com; sscozzie@us.army.mil NR 8 TC 4 Z9 4 U1 0 U2 1 PU TRANS TECH PUBLICATIONS LTD PI DURNTEN-ZURICH PA KREUZSTRASSE 10, 8635 DURNTEN-ZURICH, SWITZERLAND SN 0255-5476 J9 MATER SCI FORUM PY 2011 VL 679-680 BP 591 EP + DI 10.4028/www.scientific.net/MSF.679-680.591 PG 2 WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA BVJ83 UT WOS:000291673500142 ER PT S AU Lelis, AJ Green, R Habersat, D AF Lelis, Aivars J. Green, Ronald Habersat, Daniel BE Monakhov, EV Hornos, T Svensson, BG TI High-Temperature Reliability of SiC Power MOSFETs SO SILICON CARBIDE AND RELATED MATERIALS 2010 SE Materials Science Forum LA English DT Proceedings Paper CT 8th European Conference on Silicon Carbide and Related Materials CY AUG 29-SEP 02, 2010 CL Sundvolden Conf Ctr, Oslo, NORWAY SP Aixtron, Dow Corning, Birkeland Innovation, Centrotherm, CREE Inc, Gen Elect, LPE, Norden NordForsk, SiCED, SiCrystal AG, Res Council Norway, Univ Oslo HO Sundvolden Conf Ctr DE Oxide trap; MOSFET; leakage current; reliability ID STRESS AB We have observed a significant increase in the instability of SIC power MOSFET I-D-V-GS characteristics following bias stressing at elevated temperature, similar to the effect we previously observed following an ON-state current stress. Devices stressed by elevated temperature alone exhibited very little instability compared with devices stressed with both temperature and applied bias. These results, along with other results in the literature, suggest that this increase in threshold voltage instability at elevated temperature is due to the activation of additional near-interfacial oxide traps related to an O-vacancy defect known as an E' center. It is important to develop improved processing methods to decrease the number of precursor oxide defect sites, since an increased negative shift can give rise to increased leakage current in the OFF-state and potential device failure if proper precautions are not met to provide an adequate margin for the threshold voltage. C1 [Lelis, Aivars J.] USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Green, Ronald] US Army Res Lab, Adelphi, MD 20783 USA. RP Lelis, AJ (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM aivars.j.lelis@us.army.mil; ronald.greenjr@us.army.mil; daniel.habersat@us.army.mil NR 6 TC 20 Z9 20 U1 1 U2 6 PU TRANS TECH PUBLICATIONS LTD PI DURNTEN-ZURICH PA KREUZSTRASSE 10, 8635 DURNTEN-ZURICH, SWITZERLAND SN 0255-5476 J9 MATER SCI FORUM PY 2011 VL 679-680 BP 599 EP + DI 10.4028/www.scientific.net/MSF.679-680.599 PG 2 WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA BVJ83 UT WOS:000291673500144 ER PT S AU Veliadis, V Stewart, EJ Hearne, H McNutt, T Chang, W Snook, M Lelis, A Scozzie, C AF Veliadis, V. Stewart, E. J. Hearne, H. McNutt, Ty Chang, W. Snook, M. Lelis, A. Scozzie, C. BE Monakhov, EV Hornos, T Svensson, BG TI Design and Yield of 9 kV Unipolar Normally-ON Vertical-Channel SiC JFETs SO SILICON CARBIDE AND RELATED MATERIALS 2010 SE Materials Science Forum LA English DT Proceedings Paper CT 8th European Conference on Silicon Carbide and Related Materials CY AUG 29-SEP 02, 2010 CL Sundvolden Conf Ctr, Oslo, NORWAY SP Aixtron, Dow Corning, Birkeland Innovation, Centrotherm, CREE Inc, Gen Elect, LPE, Norden NordForsk, SiCED, SiCrystal AG, Res Council Norway, Univ Oslo HO Sundvolden Conf Ctr DE 4H-SiC; JFET; vertical channel; normally-ON; 9 kV; unipolar; yield; current-gain ID POWER; VJFETS; SWITCH AB Normally-ON 9.1 kV (at 0.1 mA/cm(2)), 1.52 x 10(-3) cm(2) active-area vertical-channel SiC JFETs (VJFETs), were fabricated at a 52% yield with no epitaxial regrowth and a three-step junction-termination-extension edge termination, which is connected to the gate bus through an ion-implanted sloped sidewall. The VJFETs exhibit low gate-to-source leakage currents of less than 1 nA up to V-GS = -60 V, and sharp onsets of breakdown occurring at V-GS similar to -80 V. The gate-to-source and gate-to-drain diodes turn on at 2.75 V, with the latter diode exhibiting higher resistance due to the thick epitaxial drift layer. To realize unipolar operation with low on-state resistance, the VJFET is designed very normally-ON which minimizes the channel resistance contribution. Consequently, threshold voltages are in the -3 V to -4.5 V range and transconductance is relatively low at < 0.36 mS. At a gate bias of 0 V, the VJFETs output a drain current of 73 mA with a forward drain voltage drop of 5 V (240 W/cm(2)), a specific on-state resistance of 104 m Omega-cm(2), and a current gain of I-D/I-G = 6.4 x 10(9). Thus, these VJFETs are capable of efficient power switching, i.e., high current-gain voltage-controlled operation at a low unipolar resistance. C1 [Veliadis, V.; Stewart, E. J.; Hearne, H.; McNutt, Ty; Chang, W.; Snook, M.] Northrop Grumman Elect Syst, Linthicum, MD 21090 USA. [Lelis, A.; Scozzie, C.] US Army Res Lab, Adelphi, MD 20783 USA. RP Veliadis, V (reprint author), Northrop Grumman Elect Syst, Linthicum, MD 21090 USA. EM victor.veliadis@ngc.com NR 11 TC 2 Z9 2 U1 1 U2 4 PU TRANS TECH PUBLICATIONS LTD PI DURNTEN-ZURICH PA KREUZSTRASSE 10, 8635 DURNTEN-ZURICH, SWITZERLAND SN 0255-5476 J9 MATER SCI FORUM PY 2011 VL 679-680 BP 617 EP + DI 10.4028/www.scientific.net/MSF.679-680.617 PG 2 WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA BVJ83 UT WOS:000291673500148 ER PT J AU Balkin, TJ Rupp, TL Newman, RA Wesensten, NJ AF Balkin, T. J. Rupp, T. L. Newman, R. A. Wesensten, N. J. TI PER3 4-REPEAT ALLELE IS ASSOCIATED WITH FASTER RECOVERY OF NEUROBEHAVIORAL PERFORMANCE FOLLOWING CHRONIC SLEEP RESTRICTION SO SLEEP LA English DT Meeting Abstract CT 25th Anniversary Meeting of the Associated-Professional-Sleep-Societies (APSS) CY JUN 11-15, 2011 CL Minneapolis, MN SP Associated Profess Sleep Soc (APSS) C1 [Balkin, T. J.; Rupp, T. L.; Newman, R. A.; Wesensten, N. J.] Walter Reed Army Inst Res, Behav Biol Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2011 VL 34 SU S MA 0056 BP A22 EP A22 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 886EG UT WOS:000299834400058 ER PT J AU Eliasson, AH Kashani, M Hoffman, J Vernalis, M AF Eliasson, A. H. Kashani, M. Hoffman, J. Vernalis, M. TI RACIAL DIFFERENCES IN PERCEIVED STRESS, SLEEP HABITS AND DAYTIME SYMPTOMS SO SLEEP LA English DT Meeting Abstract CT 25th Anniversary Meeting of the Associated-Professional-Sleep-Societies (APSS) CY JUN 11-15, 2011 CL Minneapolis, MN SP Associated Profess Sleep Soc (APSS) C1 [Eliasson, A. H.; Kashani, M.; Hoffman, J.; Vernalis, M.] Walter Reed Army Med Ctr, Integrat Cardiac Hlth Project, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2011 VL 34 SU S MA 0761 BP A262 EP A262 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 886EG UT WOS:000299834401010 ER PT J AU Killgore, DB Killgore, WD Balkin, TJ AF Killgore, D. B. Killgore, W. D. Balkin, T. J. TI SLEEP DEPRIVATION BLUNTS THE PERCEPTION OF EMOTIONAL INTENSITY IN FACES SO SLEEP LA English DT Meeting Abstract CT 25th Anniversary Meeting of the Associated-Professional-Sleep-Societies (APSS) CY JUN 11-15, 2011 CL Minneapolis, MN SP Associated Profess Sleep Soc (APSS) C1 [Killgore, W. D.] Harvard Univ, Sch Med, Belmont, MA 02178 USA. [Killgore, D. B.; Balkin, T. J.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2011 VL 34 SU S MA 0308 BP A108 EP A108 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 886EG UT WOS:000299834400309 ER PT J AU Killgore, WD Grugle, NL Balkin, TJ AF Killgore, W. D. Grugle, N. L. Balkin, T. J. TI SLEEP DEPRIVATION IMPAIRS RECOGNITION OF SPECIFIC EMOTIONS SO SLEEP LA English DT Meeting Abstract CT 25th Anniversary Meeting of the Associated-Professional-Sleep-Societies (APSS) CY JUN 11-15, 2011 CL Minneapolis, MN SP Associated Profess Sleep Soc (APSS) C1 [Killgore, W. D.] Harvard Univ, Sch Med, Belmont, MA 02178 USA. [Grugle, N. L.; Balkin, T. J.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 1 Z9 1 U1 0 U2 5 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2011 VL 34 SU S MA 0307 BP A107 EP A107 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 886EG UT WOS:000299834400308 ER PT J AU Killgore, WD Balkin, TJ AF Killgore, W. D. Balkin, T. J. TI DOES VULNERABILITY TO SLEEP DEPRIVATION INFLUENCE THE EFFECTIVENESS OF STIMULANTS ON PSYCHOMOTOR VIGILANCE? SO SLEEP LA English DT Meeting Abstract CT 25th Anniversary Meeting of the Associated-Professional-Sleep-Societies (APSS) CY JUN 11-15, 2011 CL Minneapolis, MN SP Associated Profess Sleep Soc (APSS) C1 [Killgore, W. D.] Harvard Univ, Sch Med, Belmont, MA 02178 USA. [Killgore, W. D.; Balkin, T. J.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2011 VL 34 SU S MA 0283 BP A100 EP A100 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 886EG UT WOS:000299834400284 ER PT J AU Lettieri, CJ Walter, RJ AF Lettieri, C. J. Walter, R. J. TI THE EFFECTS OF INDIVIDUAL VERSUS GROUP EDUCATION ON CPAP ADHERENCE IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA SO SLEEP LA English DT Meeting Abstract CT 25th Anniversary Meeting of the Associated-Professional-Sleep-Societies (APSS) CY JUN 11-15, 2011 CL Minneapolis, MN SP Associated Profess Sleep Soc (APSS) C1 [Lettieri, C. J.; Walter, R. J.] Walter Reed Army Med Ctr, Washington Dc, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2011 VL 34 SU S MA 0344 BP A120 EP A121 PG 2 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 886EG UT WOS:000299834400345 ER PT J AU Newman, RA Rupp, TL Wesensten, NJ Balkin, TJ AF Newman, R. A. Rupp, T. L. Wesensten, N. J. Balkin, T. J. TI ADORA2A POLYMORPHISM REGULATES NEUROBEHAVIORAL PERFORMANCE RESPONSE TO CHRONIC SLEEP RESTRICTION SO SLEEP LA English DT Meeting Abstract CT 25th Anniversary Meeting of the Associated-Professional-Sleep-Societies (APSS) CY JUN 11-15, 2011 CL Minneapolis, MN SP Associated Profess Sleep Soc (APSS) C1 [Newman, R. A.; Rupp, T. L.; Wesensten, N. J.; Balkin, T. J.] Walter Reed Army Inst Res, Behav Biol Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2011 VL 34 SU S MA 0054 BP A21 EP A21 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 886EG UT WOS:000299834400056 ER PT J AU Rupp, TL McWhirter, KK Marr, J Newman, RA Balkin, TJ AF Rupp, T. L. McWhirter, K. K. Marr, J. Newman, R. A. Balkin, T. J. TI COMPARISON OF MOTIONLOGGER WATCH AND ACTIWATCH ACTIGRAPHS TO POLYSOMNOGRAPHY IN HEALTHY YOUNG ADULTS SO SLEEP LA English DT Meeting Abstract CT 25th Anniversary Meeting of the Associated-Professional-Sleep-Societies (APSS) CY JUN 11-15, 2011 CL Minneapolis, MN SP Associated Profess Sleep Soc (APSS) C1 [Rupp, T. L.; McWhirter, K. K.; Marr, J.; Newman, R. A.; Balkin, T. J.] Walter Reed Army Inst Res, Behav Biol Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2011 VL 34 SU S MA 0316 BP A111 EP A111 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 886EG UT WOS:000299834400317 ER PT J AU Rupp, TL Wesensten, NJ Balkin, TJ AF Rupp, T. L. Wesensten, N. J. Balkin, T. J. TI INDIVIDUAL DIFFERENCES IN RESPONSES AND RECOVERY TO SLEEP DEPRIVATION AND SLEEP RESTRICTION ARE TRAIT-LIKE SO SLEEP LA English DT Meeting Abstract CT 25th Anniversary Meeting of the Associated-Professional-Sleep-Societies (APSS) CY JUN 11-15, 2011 CL Minneapolis, MN SP Associated Profess Sleep Soc (APSS) C1 [Rupp, T. L.; Wesensten, N. J.; Balkin, T. J.] Walter Reed Army Inst Res, Behav Biol Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2011 VL 34 SU S MA 0271 BP A95 EP A95 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 886EG UT WOS:000299834400272 ER PT J AU Wesensten, NJ Rupp, TL Newman, RA Balkin, TJ AF Wesensten, N. J. Rupp, T. L. Newman, R. A. Balkin, T. J. TI PER3 POLYMORPHISMS IMPACT NEUROBEHAVIORAL PERFORMANCE DURING CHRONIC SLEEP RESTRICTION SO SLEEP LA English DT Meeting Abstract CT 25th Anniversary Meeting of the Associated-Professional-Sleep-Societies (APSS) CY JUN 11-15, 2011 CL Minneapolis, MN SP Associated Profess Sleep Soc (APSS) C1 [Wesensten, N. J.; Rupp, T. L.; Newman, R. A.; Balkin, T. J.] Walter Reed Army Inst Res, Behav Biol Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2011 VL 34 SU S MA 0055 BP A21 EP A22 PG 2 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 886EG UT WOS:000299834400057 ER PT J AU Bruner, VE Woll, P AF Bruner, Victoria E. Woll, Pamela TI The Battle Within: Understanding the Physiology of War-Zone Stress Exposure SO SOCIAL WORK IN HEALTH CARE LA English DT Article DE war physiology; PTSD; recovery; shame ID MENTAL-HEALTH AB Faced with pervasive loss, life threat, and moral conflict in the field of battle, the human body and brain adapt to extraordinary circumstances in extraordinary ways. These adaptations come at a high price, and many men and women returning from Iraq and Afghanistan are paying that price every day. For the clinician who seeks to help, an understanding of the physiology of war-zone stress and resilience is an essential foundation, both for recovery from post-traumatic stress disorder and other conditions, and for addressing the stigma and shame that keep many service members and veterans from seeking and accepting the help and support they need. This article explores ways in which the body and brain adapt to war-zone stress, resulting challenges, and implications for clinical services and ongoing recovery. C1 [Bruner, Victoria E.] Walter Reed Army Med Ctr, Deployment Hlth Clin Ctr, Washington, DC 20307 USA. [Woll, Pamela] Univ Illinois, Human Prior & Great Lakes Addict Technol Transfer, Jane Addams Coll Social Work, Chicago, IL USA. RP Bruner, VE (reprint author), Walter Reed Army Med Ctr, Deployment Hlth Clin Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM VICTORIA.BRUNER@AMEDD.ARMY.MIL RI Schueter, nicos/A-3625-2014 NR 12 TC 3 Z9 3 U1 1 U2 3 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0098-1389 J9 SOC WORK HEALTH CARE JI Soc. Work Health Care PY 2011 VL 50 IS 1 BP 19 EP 33 DI 10.1080/00981389.2010.513915 PG 15 WC Social Work SC Social Work GA 726GJ UT WOS:000287707600003 PM 21240769 ER PT J AU Coll, JE Weiss, EL Yarvis, JS AF Coll, Jose E. Weiss, Eugenia L. Yarvis, Jeffrey S. TI No One Leaves Unchanged: Insights for Civilian Mental Health Care Professionals Into the Military Experience and Culture SO SOCIAL WORK IN HEALTH CARE LA English DT Article DE military culture; cultural awareness; military values; military mental health ID DISORDERS; VETERANS; STRESS AB This article aims to elucidate an understanding of military culture and experience, so as to better frame the services offered by civilian clinicians. Service members indoctrinated into such an influential culture can experience adjustment problems upon reentry into the larger society, and thus professional counselors and social workers must be ready to address the reintegration process with veteran clients. Furthermore, this article highlights a few of the major mental health concerns that are prevalent in combat veterans, especially for those returning from Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF), and presents a brief overview of treatment modalities implemented both within and outside of the military. Practical therapeutic suggestions for clinicians with little or no knowledge of the military are discussed. The objective is to educate and prepare civilian mental health practitioners to administer culturally sensitive prevention and intervention services to meet the unique needs of this population. C1 [Coll, Jose E.] St Leo Univ, Sch Educ & Social Serv, St Leo, FL 33574 USA. [Weiss, Eugenia L.] Univ So Calif, Sch Social Work, San Diego, CA USA. [Yarvis, Jeffrey S.] Walter Reed Army Med Ctr, Behav Hlth Serv, Washington, DC 20307 USA. RP Coll, JE (reprint author), St Leo Univ, Sch Educ & Social Serv, St Leo, FL 33574 USA. EM Coll@usc.edu RI Schueter, nicos/A-3625-2014 NR 31 TC 22 Z9 22 U1 0 U2 9 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0098-1389 J9 SOC WORK HEALTH CARE JI Soc. Work Health Care PY 2011 VL 50 IS 7 SI SI BP 487 EP 500 DI 10.1080/00981389.2010.528727 PG 14 WC Social Work SC Social Work GA 888PI UT WOS:000300015600002 PM 21846250 ER PT J AU French, LM Parkinson, GW Massetti, S AF French, Louis M. Parkinson, Glenn W. Massetti, Silvia TI Care Coordination in Military Traumatic Brain Injury SO SOCIAL WORK IN HEALTH CARE LA English DT Article DE traumatic brain injury; care management; civilian social workers ID VALIDITY; SOLDIERS; BLAST; IRAQ; TBI AB Traumatic brain injury (TBI)-an injury to the brain that may or may not create lasting impairment for the survivor-has been recognized as a major public health problem by the Centers for Disease Control (Langlois, Rutland-Brown, & Thomas, 2006). Ongoing conflicts in Iraq and Afghanistan have highlighted the problem for the military (Warden, 2006). Many soldiers are exposed to severe impact to the head resulting in TBI. As those with TBI transition to their home locality, civilian social workers and other providers will be involved in their care. This article examines the medical and emotional implications of mild TBI and offers suggestions for care of those affected, both the service member and his/her family. C1 [French, Louis M.; Massetti, Silvia] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. [French, Louis M.; Parkinson, Glenn W.] Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20307 USA. [French, Louis M.; Massetti, Silvia] Natl Naval Med Ctr, Bethesda, MD USA. [French, Louis M.] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. [Parkinson, Glenn W.] Walter Reed Army Med Ctr, Dept Neurol, Washington, DC 20307 USA. RP French, LM (reprint author), Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, 6900 Georgia Ave NW,Bldg 2,Room 2J41, Washington, DC 20307 USA. EM louis.french@us.army.mil NR 19 TC 3 Z9 3 U1 1 U2 3 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0098-1389 J9 SOC WORK HEALTH CARE JI Soc. Work Health Care PY 2011 VL 50 IS 7 SI SI BP 501 EP 514 DI 10.1080/00981389.2011.582007 PG 14 WC Social Work SC Social Work GA 888PI UT WOS:000300015600003 PM 21846251 ER PT J AU Beder, J Coe, R Sommer, D AF Beder, Joan Coe, Ray Sommer, Darren TI Women and Men Who Have Served in Afghanistan/Iraq: Coming Home SO SOCIAL WORK IN HEALTH CARE LA English DT Article DE reintegration; war; soldiers; coming home; adjustment ID VETERANS; DEPLOYMENT; IRAQ; WAR AB The experience of war changes people - some will acknowledge that the changes are positive and some will feel the opposite or a combination, but that it changes a person cannot be disputed. For those who return, the experience of reintegration to civilian life or as a respite before redeployment can present numerous challenges. The research presented in this article reports the findings on interviews with over 800 service members who had returned from either Afghanistan or Iraq. The Post Deployment Reintegration Scale was used to refine the areas that respondents identified as positive or negative in their reintegration experience. Implications for practice with returning service members are noted. C1 [Beder, Joan] Yeshiva Univ, Wurzweiler Sch Social Work, New York, NY 10033 USA. [Coe, Ray] Womack Med Ctr, Ft Bragg, NC USA. [Sommer, Darren] Premier Hlth Care Serv, Hosp Div, Dayton, OH USA. RP Beder, J (reprint author), Yeshiva Univ, Wurzweiler Sch Social Work, 2495 Amsterdam Ave, New York, NY 10033 USA. EM beder@yu.edu RI Schueter, nicos/A-3625-2014 NR 14 TC 16 Z9 16 U1 2 U2 6 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0098-1389 J9 SOC WORK HEALTH CARE JI Soc. Work Health Care PY 2011 VL 50 IS 7 SI SI BP 515 EP 526 DI 10.1080/00981389.2011.554279 PG 12 WC Social Work SC Social Work GA 888PI UT WOS:000300015600004 PM 21846252 ER PT S AU Chaitankar, V Zhang, CY Ghosh, P Gong, P Perkins, EJ Deng, YP AF Chaitankar, Vijender Zhang, Chaoyang Ghosh, Preetam Gong, Ping Perkins, Edward J. Deng, Youping BE Arabnia, HR Tran, QN TI Predictive Minimum Description Length Principle Approach to Inferring Gene Regulatory Networks SO SOFTWARE TOOLS AND ALGORITHMS FOR BIOLOGICAL SYSTEMS SE Advances in Experimental Medicine and Biology LA English DT Article; Book Chapter ID INFORMATION AB Reverse engineering of gene regulatory networks using information theory models has received much attention due to its simplicity, low computational cost, and capability of inferring large networks. One of the major problems with information theory models is to determine the threshold that defines the regulatory relationships between genes. The minimum description length (MDL) principle has been implemented to overcome this problem. The description length of the MDL principle is the sum of model length and data encoding length. A user-specified fine tuning parameter is used as control mechanism between model and data encoding, but it is difficult to find the optimal parameter. In this work, we propose a new inference algorithm that incorporates mutual information (MI), conditional mutual information (CMI), and predictive minimum description length (PMDL) principle to infer gene regulatory networks from DNA microarray data. In this algorithm, the information theoretic quantities MI and CMI determine the regulatory relationships between genes and the PMDL principle method attempts to determine the best MI threshold without the need of a user-specified fine tuning parameter. The performance of the proposed algorithm is evaluated using both synthetic time series data sets and a biological time series data set (Saccharomyces cerevisiae). The results show that the proposed algorithm produced fewer false edges and significantly improved the precision when compared to existing MDL algorithm. C1 [Chaitankar, Vijender; Zhang, Chaoyang; Ghosh, Preetam] Univ So Mississippi, Sch Comp, Hattiesburg, MS 39402 USA. [Gong, Ping; Deng, Youping] SpecPro Inc, Vicksburg, MS 39180 USA. [Perkins, Edward J.] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Zhang, CY (reprint author), Univ So Mississippi, Sch Comp, Hattiesburg, MS 39402 USA. EM chaoyang.zhang@usm.edu NR 14 TC 1 Z9 1 U1 0 U2 2 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0065-2598 BN 978-1-4419-7045-9 J9 ADV EXP MED BIOL JI Adv.Exp.Med.Biol. PY 2011 VL 696 BP 37 EP 43 DI 10.1007/978-1-4419-7046-6_4 D2 10.1007/978-1-4419-7046-6 PG 7 WC Biology; Mathematical & Computational Biology; Medicine, Research & Experimental SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational Biology; Research & Experimental Medicine GA BUK92 UT WOS:000289694000004 PM 21431544 ER PT J AU Clausen, JL Scott, C Osgerby, I AF Clausen, J. L. Scott, C. Osgerby, I. TI Fate of Nitroglycerin and Dinitrotoluene in Soil at Small Arms Training Ranges SO SOIL & SEDIMENT CONTAMINATION LA English DT Article DE Nitroglycerine; dinitrotoluene; partitioning coefficient; small arms training; biodegradation ID 2,6-DINITROTOLUENE; CONTAMINANTS AB Nitroglycerine (NG), 2-4-dinitrotoluene, and 2,6-dinitrotolune (DNTs), commonly deposited on soil during military training, have been identified as potential threats to groundwater at Camp Edwards on the Massachusetts Military Reservation. Accordingly, a series of experiments were performed to obtain site-specific sorption coefficients (K(d)) for use in computer simulations. Experiments employing aqueous, reagent-grade contaminants, with a biocide added, showed NG underwent limited sorption onto the sandy soil from the study area. DNTs were retained to a greater extent. Desorption experiments demonstrated a portion of the contaminants were irreversibly bound. Soil characteristics had a significant effect on K(d), apparently because of changes in organic carbon, cation exchange capacity, and/or clay content with depth in the soil profile. Experiments with NG containing soil, fresh, unfired propellant, or with freshly fired propellant produced partitioning values considerably higher than those observed with reagent grade material added from solution-demonstrating dissolution as the rate-limiting step. The apparent Kd also increased significantly when no biocide was used, thereby indicating a major role for biodegradation. In addition, NG and the DNTs introduced during military training did not leach from site soil at the small arms ranges studied. Taken together these data demonstrate that K(d)s from laboratory experiments using dissolved reagent-grade compounds are not appropriate for predicting NG and DNT mobility in the field. C1 [Clausen, J. L.; Scott, C.] USA, Corps Engineers, ERDC CRREL, Hanover, NH 03755 USA. [Osgerby, I.] USA, Corps Engineers, Concord, MA USA. RP Clausen, JL (reprint author), USA, Corps Engineers, ERDC CRREL, 72 Lyme Rd, Hanover, NH 03755 USA. EM Jay.L.Clausen@us.army.mil FU U.S. Army Corps of Engineers, New England District FX The authors would like to acknowledge the assistance of N. Mulherin in conducting the experiments and S. Bigl, both of CRREL, for analysis of the samples. The authors would also like to acknowledge the U.S. Army Corps of Engineers, New England District, for funding this study and the Impact Area Groundwater Study Program at Camp Edwards for site access. NR 38 TC 5 Z9 5 U1 4 U2 9 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1532-0383 J9 SOIL SEDIMENT CONTAM JI Soil. Sediment. Contam. PY 2011 VL 20 IS 6 BP 649 EP 671 DI 10.1080/15320383.2011.594108 PG 23 WC Environmental Sciences SC Environmental Sciences & Ecology GA 871LX UT WOS:000298740700003 ER PT J AU Johnson, B Zhang, ZL Velleux, M Julien, P AF Johnson, Billy Zhang, Zhonglong Velleux, Mark Julien, Pierre TI Development of a Distributed Watershed Contaminant Transport, Transformation, and Fate (CTT&F) Sub-model SO SOIL & SEDIMENT CONTAMINATION LA English DT Article DE Watershed; runoff; sediment; distributed model; contaminant transport; transformation; explosives ID FLOW; DISSOLUTION; RANGES AB CTT&F is a physically based, spatially distributed watershed contaminant transport, transformation, and fate sub-model designed for use within existing hydrological modeling systems. To describe the fate of contaminants through landscape media as well as spatial variations of contaminant distributions, physical transport and transformation processes in CTT&F are simulated for each cell in the model and routed to the watershed outlet. CTT&F simulates contaminant erosion from soil and transport across the land surface by overland flow. The model also simulates contaminant erosion from stream bed sediment and transport through channels in addition to transport of contaminants inputs by overland flow. CTT&F can simulate solid (granular) contaminant transport and transformation, including partitioning between freely dissolved, dissolved organic carbon (DOC) bound, and particle-sorbed phases. To demonstrate model capabilities, CTT&F was coupled with an existing distributed hydrologic model and was tested and validated to simulate RDX and TNT transport using two experimental plots. These experiments examined dissolution of solid contaminants into the dissolved phase and their subsequent transport to the plot outlet. Model results were in close agreement with measured data. Such a model provides information for decision makers to make rational decisions relevant to the fate of toxic compounds. C1 [Johnson, Billy] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS USA. [Zhang, Zhonglong] SpecPro, Vicksburg, MS USA. [Velleux, Mark] HydroQual Inc, Mahwah, NJ USA. [Julien, Pierre] Colorado State Univ, Dept Civil Engn, Ft Collins, CO 80523 USA. RP Johnson, B (reprint author), 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Billy.E.Johnson@usace.army.mil FU U.S. Army Corps of Engineers Environmental Quality Technology Research Program FX This work was supported by the U.S. Army Corps of Engineers Environmental Quality Technology Research Program. We greatly acknowledge and appreciate the laboratory experiment work conducted by Ms. Cynthia Price and her team. NR 29 TC 1 Z9 1 U1 1 U2 5 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1532-0383 J9 SOIL SEDIMENT CONTAM JI Soil. Sediment. Contam. PY 2011 VL 20 IS 6 BP 702 EP 721 DI 10.1080/15320383.2011.594111 PG 20 WC Environmental Sciences SC Environmental Sciences & Ecology GA 871LX UT WOS:000298740700006 ER PT S AU Cole, B Hays, A Lei, J Schilling, B Goldberg, L AF Cole, Brian Hays, Alan Lei, Jonathan Schilling, Brad Goldberg, Lew BE Clarkson, WA Hodgson, N Shori, R TI Optically triggered Cr:YAG Q-switched Nd:YAG laser SO SOLID STATE LASERS XX: TECHNOLOGY AND DEVICES SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Solid State Lasers XX - Technology and Devices CY JAN 23-27, 2011 CL San Francisco, CA SP SPIE DE Solid state lasers; Nd:YAG; passively Q-switched ID TIMING JITTER; NDYAG LASER; SATURABLE ABSORBER; REDUCTION AB The method of optical triggering using a brass board architecture for a Q-switched Nd:YAG laser by direct bleaching of a Cr:YAG saturable absorber was determined to be effective in reducing the pulse-to-pulse timing jitter. A miniaturized triggering setup was employed to enable the brass board operation of the optically triggered laser. A 3mm wide mini-laser diode bar (1024nm) with collimated emission was mounted on a compact heat sink and used to bleach the Cr: YAG saturable absorber from a direction orthogonal to the lasing axis. A compact 300A pulse driver, with <0.5 mu s rise time and 3-5 mu s duration, was developed for pulsing the 3mm diode bar. These components were combined to demonstrate a compact brassboard implementation of the optically triggered passively Q-switched laser. C1 [Cole, Brian; Hays, Alan; Lei, Jonathan; Schilling, Brad; Goldberg, Lew] USA, Night Vis & Elect Sensors Directorate, RDECOM CERDEC, Ft Belvoir, VA 22060 USA. RP Cole, B (reprint author), USA, Night Vis & Elect Sensors Directorate, RDECOM CERDEC, Ft Belvoir, VA 22060 USA. NR 11 TC 1 Z9 1 U1 1 U2 5 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8449-9 J9 PROC SPIE PY 2011 VL 7912 AR 79120X DI 10.1117/12.873937 PG 7 WC Optics; Physics, Applied SC Optics; Physics GA BXZ84 UT WOS:000297726600026 ER PT S AU Cole, B King, V Leach, J Goldberg, L AF Cole, Brian King, Vernon Leach, Jeff Goldberg, Lew BE Clarkson, WA Hodgson, N Shori, R TI Role of UV illumination for enabling cold temperature operation of a LiNbO(3) Q-switched Nd:YAG laser SO SOLID STATE LASERS XX: TECHNOLOGY AND DEVICES SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Solid State Lasers XX - Technology and Devices CY JAN 23-27, 2011 CL San Francisco, CA SP SPIE DE Solid state lasers; Nd:YAG; active Q-switching AB We have explored using UV illumination as a method to mitigate pyroelectric effects, and their associative loss in hold-off for lithium niobate Q-switch materials under cold temperature operation. It has been observed that by illumination of the LiNbO(3) Q-switch material from the side, the above bandgap light can provide for an increase in conductivity via an increase in photocarriers. In the presence of strong pyroelectric fields associated with a change in temperature, these carriers can be effectively swept in the direction to eliminate the field. We quantified the improvement in conduction by measuring the decay time for the pyroelectric induced loss in extinction. At negative 20 degrees C, the decay rate for the pyroelectric field in the absence of UV illumination was measured to be 16.7 hours. It was found that by illuminating the LiNbO(3) from the side with two UV LEDs operating at 500mA, the decay constant for a built-up pyroelectric charge could be reduced to 1minute. With this technique applied to a LiNbO(3) Q-switched laser, the laser was shown to perform over rapid cooling without a degradation in performance. C1 [Cole, Brian; King, Vernon; Leach, Jeff; Goldberg, Lew] USA, Night Vis & Elect Sensors Directorate, RDECOM CERDEC, Ft Belvoir, VA 22060 USA. RP Cole, B (reprint author), USA, Night Vis & Elect Sensors Directorate, RDECOM CERDEC, Ft Belvoir, VA 22060 USA. NR 7 TC 0 Z9 0 U1 1 U2 3 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8449-9 J9 PROC SPIE PY 2011 VL 7912 AR 791224 DI 10.1117/12.873935 PG 6 WC Optics; Physics, Applied SC Optics; Physics GA BXZ84 UT WOS:000297726600058 ER PT J AU Phasomkusolsil, S Lerdthusnee, K Khuntirat, B Kongtak, W Pantuwatana, K Murphy, JR AF Phasomkusolsil, Siriporn Lerdthusnee, Kriangkrai Khuntirat, Benjawan Kongtak, Weeraphan Pantuwatana, Kanchana Murphy, Jittawadee R. TI EFFECT OF TEMPERATURE ON LABORATORY REARED ANOPHELES DIRUS PEYTON AND HARRISON AND ANOPHELES SAWADWONGPORNI RATTANARITHIKUL AND GREEN SO SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH LA English DT Article DE Anopheles dims; Anopheles sawadwongporni; temperature; body size; fecundity ID AEDES-ALBOPICTUS DIPTERA; CULICIDAE BODY SIZE; WING LENGTH; AEGYPTI DIPTERA; LARVAL DIET; ADULT SIZE; DRY-WEIGHT; POPULATION; SUSCEPTIBILITY; PARITY AB Investigations have shown that female mosquitoes with a larger body size (determined by wing length) exhibit higher feeding rates and greater fecundity relative to smaller mosquitoes. In this study, Anopheles dirus and An. sawadwongporni were reared in the laboratory at two different temperatures (23 degrees C and 30 C). Effects of the rearing temperature on body size, fecundity, and larval development period were examined by measuring wing length, adult body weight at emergence, the number of eggs produced and the length of time from the first to the fourth instar. Rearing temperature had a direct effect on body size, fecundity and larval development period for both species. Mosquitoes of both species reared at 23 degrees C were larger in body size, experienced prolonged development and produced a larger clutch of eggs relative to mosquitoes reared at 30 degrees C. However, there was no temperature effect on egg hatching rate and sex ratio. C1 [Phasomkusolsil, Siriporn; Lerdthusnee, Kriangkrai; Khuntirat, Benjawan; Kongtak, Weeraphan; Pantuwatana, Kanchana; Murphy, Jittawadee R.] Armed Forces Res Inst Med Sci, Dept Entomol, US Army Med Component, Bangkok 10400, Thailand. [Khuntirat, Benjawan] Armed Forces Res Inst Med Sci, Dept Virol, US Army Med Component, Bangkok 10400, Thailand. [Murphy, Jittawadee R.] Walter Reed Army Inst Res, Dept Mosquito Biol, Div Entomol, Silver Spring, MD USA. RP Phasomkusolsil, S (reprint author), Armed Forces Res Inst Med Sci, Dept Entomol, US Army Med Component, 315-6 Ratchawithi Rd, Bangkok 10400, Thailand. EM siripornp@afrims.org FU US Army Medical and Material Command FX All the experiments involving animals were approved by the AFRIMS's Institutional Animal Care and Use Committee. Funding for this project was partially provided by the US Army Medical and Material Command. The views expressed in this paper are those of the authors and do not purport to represent the position and/or reflect the official policy of the Department of the Army, the Department of Defense or the US Government. We would like to thank Ms Jaruwan Tawong and Ms Nantaporn Monkanna for providing technical support and Ms Somporn Krasaesub for her helpful advice on data analysis. The authors wish to express their gratitude to Maj Brian P Evans, Department of Entomology, US Army Medical Component of the Armed Forces Research Institute of Medical Sciences (USAMC-AFRIMS) and Col Chaiyaphruk Pilakasiri, Royal Thai Army, Armed Forces Research Institute of Medical Sciences (RTA-AFRIMS), Bangkok, Thailand, for their constructive comments and valuable support. NR 34 TC 2 Z9 2 U1 0 U2 5 PU SOUTHEAST ASIAN MINISTERS EDUC ORGANIZATION PI BANGKOK PA SEAMEO-TROPMED, 420-6 RAJVITHI RD,, BANGKOK 10400, THAILAND SN 0125-1562 J9 SE ASIAN J TROP MED JI Southeast Asian J. Trop. Med. Public Health PD JAN PY 2011 VL 42 IS 1 BP 63 EP 70 PG 8 WC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine SC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine GA 720KF UT WOS:000287278900010 PM 21323167 ER PT J AU Aldalahmeh, S Ghogho, M Swami, A AF Aldalahmeh, Sami Ghogho, Mounir Swami, Ananthram GP IEEE TI DISTRIBUTED DETECTION OF AN UNKNOWN TARGET IN CLUSTERED WIRELESS SENSOR NETWORKS SO SPAWC 2011: 2011 IEEE 12TH INTERNATIONAL WORKSHOP ON SIGNAL PROCESSING ADVANCES IN WIRELESS COMMUNICATIONS LA English DT Proceedings Paper CT 12th IEEE International Workshop on Signal Processing Advances in Wireless Communications CY JUN 26-29, 2011 CL San Francisco, CA SP IEEE AB We consider the problem of distributed detection in wire-less sensor networks. The sensors are randomly deployed according to a Poisson point process. The received power of the signal emanating for man intruding target is assumed to follow the inverse power law. We propose the real-time counting rule (rt-CR) detector to endow the system with real-time detection delay capabilities. We show that the number of detecting sensor nodes, for any target type and any detector, follows a Poisson distribution. An exact expression for the average number of detecting sensor nodes is found. Simulation results support the accuracy of our theoretical prediction. C1 [Aldalahmeh, Sami; Ghogho, Mounir] Univ Leeds, Leeds LS2 9JT, W Yorkshire, England. [Ghogho, Mounir] Int Univ, Rabat, Morocco. [Swami, Ananthram] US Army, Res Lab, Adelphi, MD USA. RP Aldalahmeh, S (reprint author), Univ Leeds, Leeds LS2 9JT, W Yorkshire, England. EM elsaa@leeds.ac.uk; m.ghogho@ieee.org; a.swami@ieee.org NR 14 TC 4 Z9 4 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-9332-6 PY 2011 BP 126 EP 130 PG 5 WC Computer Science, Hardware & Architecture; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BYK47 UT WOS:000299165600026 ER PT S AU Fischenich, JC AF Fischenich, J. Craig BE Simon, A Bennett, SJ Castro, JM TI Stream Restoration Benefits SO STREAM RESTORATION IN DYNAMIC FLUVIAL SYSTEMS: SCIENTIFIC APPROACHES, ANALYSES, AND TOOLS SE Geophysical Monograph Series LA English DT Article; Book Chapter ID RIVER RESTORATION; ECOSYSTEM SERVICES; ECOLOGICAL PROCESSES; REHABILITATION; MANAGEMENT; VALUATION; SYSTEMS; MODELS; CONSERVATION; VARIABILITY AB More than 1 billion dollars is spent annually restoring degraded streams and rivers in the United States alone because of the perceived value that healthy streams and rivers provide. Despite this immense investment, quantifying the benefits from these projects is often neglected. Without this step, it is difficult to compare restoration alternatives, prioritize projects, and determine the real returns on investment. While there are many factors that make quantification difficult, a more rigid adherence to and acceptance of the benefits assessments process will improve the ability of practitioners and sponsors to assess the value of their investment. Further, current practice can be improved with the explicit use of conceptual models, establishment of clear objectives and associated metrics, better predictive tools, quantification of uncertainty, more structured decision methods, and adaptive management. This chapter provides both a theoretical foundation and a practical framework for the vital process of assessing the benefits of stream restoration projects. C1 US Army Corps Engineers, ERDC Environm Lab, Vicksburg, MS 39183 USA. RP Fischenich, JC (reprint author), US Army Corps Engineers, ERDC Environm Lab, Vicksburg, MS 39183 USA. NR 85 TC 0 Z9 0 U1 1 U2 2 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0065-8448 BN 978-1-118-66667-8; 978-0-87590-483-2 J9 GEOPHYS MONOGR SER PY 2011 VL 194 BP 45 EP 67 DI 10.1029/2010GM001010 D2 10.1029/GM194 PG 23 WC Geosciences, Multidisciplinary; Water Resources SC Geology; Water Resources GA BA5PW UT WOS:000336929500005 ER PT S AU Smith, DL Allen, JB Eslinger, O Valenciano, M Nestler, J Goodwin, RA AF Smith, David L. Allen, Jeffrey B. Eslinger, Owen Valenciano, Miguel Nestler, John Goodwin, R. Andrew BE Simon, A Bennett, SJ Castro, JM TI Hydraulic Modeling of Large Roughness Elements With Computational Fluid Dynamics for Improved Realism in Stream Restoration Planning SO STREAM RESTORATION IN DYNAMIC FLUVIAL SYSTEMS: SCIENTIFIC APPROACHES, ANALYSES, AND TOOLS SE Geophysical Monograph Series LA English DT Article; Book Chapter ID WALL SKIN FRICTION; FLOOD INUNDATION; RIVER; PREDICTION; CHANNEL AB Many stream restoration design procedures are based on user experience in distributing standard stream design features into stream channel types based on a stream classification scheme. Computational fluid dynamics (CFD) models, increasingly used to represent stream flow fields, offer a more quantitative path forward. However, CFD models, in practice, parameterize roughness on too large a scale and therefore do not explicitly represent discrete features such as large rocks and large woody material whose placement is the focus of stream restoration activities. The Stream Habitat Assessment Package (SHAPE), made possible by rapid advances and availability of high-performance computing resources and increased sophistication of both in-house and commercial software, overcomes barriers that prevent the routine use of CFD modeling in stream restoration planning. Capabilities of SHAPE that improve stream restoration planning include (1) realistically representing natural streambeds from potentially coarse sets of field measurements, (2) easily deforming the streambed surface with a virtual excavator, (3) selecting complex objects from a library and embedding them within the surface (e. g., rocks and fallen trees), (4) successfully meshing the channel surface and its surrounding volume in accordance with established mesh quality criteria, and (5) sufficiently resolving flow field solutions. We illustrate these capabilities of SHAPE using a coarse set of field data taken from one of four study sites along a 1.5 mile stretch along the Robinson Restoration project of the Merced River, California, along with respective challenges, solution strategies, and resulting outcomes. Flow field solutions are conducted using parallelized finite element/volume solvers. C1 [Smith, David L.; Nestler, John] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Allen, Jeffrey B.; Eslinger, Owen] US Army Engineer Res & Dev Ctr, Informat Technol Lab, Vicksburg, MS USA. [Valenciano, Miguel] Data Management Consultants, Diberville, MS USA. [Goodwin, R. Andrew] US Army Engineer Res & Dev Ctr, Environm Lab, Portland, OR USA. RP Smith, DL (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. NR 21 TC 1 Z9 1 U1 1 U2 2 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0065-8448 BN 978-1-118-66667-8; 978-0-87590-483-2 J9 GEOPHYS MONOGR SER PY 2011 VL 194 BP 115 EP 122 DI 10.1029/2010GM000988 D2 10.1029/GM194 PG 8 WC Geosciences, Multidisciplinary; Water Resources SC Geology; Water Resources GA BA5PW UT WOS:000336929500008 ER PT J AU Edge, H Chung, H Coatney, M Mary, B Tibbits, P Murugan, M Ghoshal, A Le, D Pappakostas, M AF Edge, H. Chung, H. Coatney, M. Mary, B. Tibbits, P. Murugan, M. Ghoshal, A. Le, D. Pappakostas, M. BE Chang, FK TI Real-Time Micro-Explosive Damage Detection in an Unmanned Rotorcraft Vehicle Using Embedded Sensing SO STRUCTURAL HEALTH MONITORING 2011: CONDITION-BASED MAINTENANCE AND INTELLIGENT STRUCTURES, VOL 1 SE Structural Health Monitoring LA English DT Proceedings Paper CT 8th International Workshop on Structural Health Monitoring CY SEP 13-15, 2011 CL Stanford Univ, Stanford, CA SP AF Off Sci Res, Army Res Off, Natl Sci Fdn, Off Naval Res HO Stanford Univ AB Demonstration of damage detection and related Health and Usage Monitoring System (HUMS) technologies for condition-based maintenance (CBM) is most convincingly done through flight testing. Demonstration of damage detection using manned aircraft may not be feasible due to airworthiness requirements which must ensure safety of the flight crew. However, demonstrations using an Unmanned Air Vehicle (UAV) provide unique opportunities to test the in-flight detection and monitoring of damage to critical aircraft components without risking a flight crew. UAV demonstrations can therefore initiate faults into primary aircraft structure while in flight to study real-time fault-sensing capability of advanced sensors. The U.S. Army Research Laboratory (ARL) is collaborating with Acellent Technologies to demonstrate the diagnostics capability of advanced sensor systems to detect embedded flaws/damage on structural components using an unmanned rotorcraft vehicle (URV). ARL developed innovative techniques to initiate controlled flaw/damage using micro-explosives on a principal structural element (PSE) on the URV. The selected PSE on the URV is a side plate, shielding the engine compartment of RAPTOR 90. Two Acellent SMART Layer sensor patches were surface bonded to the damaged panel. The installed sensor systems can actuate and receive guided Lamb waves at multiple frequencies simultaneously. Data collected from the damaged PSE, compared with the baseline signals collected prior to the damage, showed change in amplitude and phase of the signals, indicating the presence of damage. Analysis of the signals by the Acellent Smart Patch software indicated a structural change within the PSE from the damage initiated by the micro-explosive. A ground-based flight test stand was developed and built to inexpensively address concerns about the safety of personnel in the area of operation of the selected URV. Preliminary tethered flight tests were then conducted as a risk reduction to planned free flight tests within the Army airspace. An autopilot was developed and control parameters were determined. The tethered flight tests showed that stable, autonomous flight could be achieved. C1 [Edge, H.; Coatney, M.; Mary, B.; Tibbits, P.; Murugan, M.; Ghoshal, A.; Le, D.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Edge, H (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 10 TC 0 Z9 0 U1 0 U2 3 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-053-2 J9 STRUCT HLTH MONIT PY 2011 BP 405 EP 412 PG 8 WC Endocrinology & Metabolism; Instruments & Instrumentation SC Endocrinology & Metabolism; Instruments & Instrumentation GA BXY69 UT WOS:000297634100048 ER PT J AU Ayers, J Swenson, E Ruzzene, M Ghoshal, A AF Ayers, J. Swenson, E. Ruzzene, M. Ghoshal, A. BE Chang, FK TI Mode Conversion Estimation of Filleted T-Joint Using FEM and 3D Laser Vibrometry SO STRUCTURAL HEALTH MONITORING 2011: CONDITION-BASED MAINTENANCE AND INTELLIGENT STRUCTURES, VOL 1 SE Structural Health Monitoring LA English DT Proceedings Paper CT 8th International Workshop on Structural Health Monitoring CY SEP 13-15, 2011 CL Stanford Univ, Stanford, CA SP AF Off Sci Res, Army Res Off, Natl Sci Fdn, Off Naval Res HO Stanford Univ ID DAMAGE DETECTION; WAVE AB T-joint configurations, commonly found in aerospace applications, provide a challenge for structural health monitoring (SHM) strategies that employ wave propagation based interrogation techniques. The challenge arises from the complexity of wave propagation through the T-joint interface, and the consequent mode conversion and reflections. This work presents a numerical characterization of undamaged T-joint using simplified two-dimensional (2D) plane strain finite element (FE) models, where excitation from a piezoelectric actuator is simulated on one side of the T-joint. The incident and consequent reflected waveforms are separated in the frequency-wavenumber domain, and spatially-integrated multiple component mode coefficients are formulated in the frequency-spatial domain with the intent to characterize wave reflections and mode conversions. Mode coefficients from the undamaged configuration are compared to T-joints with blind side notch damage located in the fillet radius. Trends from the 2D FE numerical studies are verified by a three dimensional (3D) Scanning Laser Vibrometer test setup for the undamaged case, which consists of an aluminum T-joint for selected fillet radius (0.6 cm) and stiffener thickness (0.3 cm). The setup enables 3D full wavefield surface measurements of the front and back sides of the plate, plate-stiffener radius, and stiffener. Recommendations of how to use the mode coefficient formulation as a damage quantification tool for the T-joint are given. C1 [Ayers, J.; Ghoshal, A.] USA, Res Lab, Aberdeen, MD USA. RP Ayers, J (reprint author), USA, Res Lab, Aberdeen, MD USA. EM james.t.ayers@us.army.mil; Eric.Swenson@afit.edu; ruzzene@gatech.edu; anindya.ghoshal@us.army.mil NR 11 TC 0 Z9 0 U1 0 U2 4 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-053-2 J9 STRUCT HLTH MONIT PY 2011 BP 997 EP 1004 PG 8 WC Endocrinology & Metabolism; Instruments & Instrumentation SC Endocrinology & Metabolism; Instruments & Instrumentation GA BXY69 UT WOS:000297634100121 ER PT J AU Winter, L AF Winter, Lucas TI The Abdullah Azzam Brigades SO STUDIES IN CONFLICT & TERRORISM LA English DT Article AB This article looks at the growth and evolution of the The Abdullah Azzam Brigades, from the group's Egyptian origins through its most recent attack on a Japanese tanker in the Hormuz Straits. In addition to an overview of the group's main personalities and claims of responsibility, the article aims to explain the group by placing it in the context of recent jihadi theory. C1 USA, Foreign Mil Studies Off, Ft Leavenworth, KS USA. RP Winter, L (reprint author), USA, Foreign Mil Studies Off, Ft Leavenworth, KS USA. EM lucasgwinter@gmail.com NR 33 TC 0 Z9 0 U1 1 U2 2 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1057-610X J9 STUD CONFL TERROR JI Stud. Confl. Terror. PY 2011 VL 34 IS 11 BP 883 EP 895 DI 10.1080/1057610X.2011.611935 PG 13 WC International Relations; Political Science SC International Relations; Government & Law GA 888FW UT WOS:000299990200004 ER PT S AU Lavan, MJ Wachs, JJ AF Lavan, Michael J. Wachs, John J. BE Titterton, DH Richardson, MA TI US Army High Energy Laser (HEL) Technology Program SO TECHNOLOGIES FOR OPTICAL COUNTERMEASURES VIII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Technologies for Optical Countermeasures VIII CY SEP 21-22, 2011 CL Prague, CZECH REPUBLIC SP SPIE AB The US Army is investing in Solid State Laser (SSL) technology to assess counter rocket, artillery, and mortar (C-RAM) and counter unmanned aerial vehicle (C-UAV) capabilities of solid state based HEL systems, as well as other potential applications for HELs of interest to the Army. The Army HEL program thrust areas are systematically moving the technology forward toward weaponization, including solid state laser technologies, advances in beam control technology, and conducting major demonstrations. The High Energy Laser Mobile Demonstrator (HELMD) will be a major step toward demonstrating HEL weapon capability to the soldier. The US Army will continue to pursue technologies that enable more compact systems compatible with, for example, a Stryker tactical vehicle as a crucial part of our strategy to provide a capability to the warfighter that can maneuver with the force. C1 [Lavan, Michael J.; Wachs, John J.] USA, Emerging Technol Directorate, Space & Missile Def Command, Ctr Tech,AF Strateg Command USASMDC ARSTRAT, Huntsville, AL 35807 USA. RP Lavan, MJ (reprint author), USA, Emerging Technol Directorate, Space & Missile Def Command, Ctr Tech,AF Strateg Command USASMDC ARSTRAT, Huntsville, AL 35807 USA. NR 0 TC 1 Z9 1 U1 2 U2 6 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-815-2 J9 PROC SPIE PY 2011 VL 8187 AR 818704 DI 10.1117/12.903729 PG 12 WC Optics; Physics, Applied SC Optics; Physics GA BXX95 UT WOS:000297571800002 ER PT J AU Mahnke, CB Jordan, CP Bergvall, E Person, DA Pinsker, JE AF Mahnke, Christopher Becket Jordan, Christopher P. Bergvall, Ethan Person, Donald A. Pinsker, Jordan E. TI The Pacific Asynchronous TeleHealth (PATH) System: Review of 1,000 Pediatric Teleconsultations SO TELEMEDICINE AND E-HEALTH LA English DT Review DE pediatrics; telemedicine; asynchronous; military medicine ID TELEMEDICINE; CHILDREN; CARE AB Objective: The aim of this study was to evaluate the impact on pediatric care of the Pacific Asynchronous TeleHealth (PATH) system, a provider-to-provider teleconsultation platform utilized by military medical facilities throughout the Pacific Region. This review focuses on access to care, quality of care, and cost savings for the Department of Defense as a result of ongoing development of the PATH system from 2006 to 2009. Methods: This is a retrospective review of 1,000 consecutive teleconsultations occurring from January 2006 to March 2009. Three pediatric subspecialists reviewed the characteristics of each teleconsultation and the ultimate outcome. Results: The PATH system processed > 300 pediatric teleconsultations in 2009 from 20 hospitals and clinics throughout the Pacific Region. The number of teleconsultations has grown significantly since 2006. Median teleconsultation response time was 14.5 h with 97% of teleconsultations answered within 1 week. The majority (75%) of teleconsultations came from areas without host nation pediatric subspecialty resources. Most teleconsultations (72%) involved diagnostic questions, whereas 21% were primarily for treatment issues. Teleconsultations originated predominantly from outpatient clinics (90%), with question resolution in 60% of cases without a face-to-face subspecialty evaluation. Fifteen percent of teleconsultations resulted in patient transfer to our center for definitive diagnosis and treatment. The diagnostic and/or treatment plan was modified in 74% of teleconsultations. PATH precluded patient transfer in 12%-43% of teleconsultations (annual savings: $208,283-$746,348 per year) and generated an average of 1.7 relative value units per teleconsultation. Conclusions: PATH provided patient access to pediatric subspecialty expertise via provider-to-provider asynchronous teleconsultation. Internet-based pediatric subspecialty teleconsultation provides fast, convenient, cost-effective, quality pediatric care to populations of patients who might otherwise require transfer to a distant medical facility for more advanced care. PATH serves as a model for future asynchronous teleconsultation platforms in both the military and civilian healthcare arenas. C1 [Mahnke, Christopher Becket; Jordan, Christopher P.; Bergvall, Ethan; Person, Donald A.; Pinsker, Jordan E.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. RP Mahnke, CB (reprint author), Tripler Army Med Ctr, Dept Pediat, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM christopher.mahnke@us.army.mil OI Pinsker, Jordan/0000-0003-4080-9034 FU U.S. Army's Telemedicine and Advanced Technology Research Center's (TATRC) AMEDD Advanced Medical Technology Initiative (AAMTI) FX The PATH system development has been partially funded by the U.S. Army's Telemedicine and Advanced Technology Research Center's (TATRC) AMEDD Advanced Medical Technology Initiative (AAMTI) program. NR 6 TC 14 Z9 14 U1 1 U2 3 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-5627 J9 TELEMED E-HEALTH JI Telemed. e-Health PD JAN-FEB PY 2011 VL 17 IS 1 BP 35 EP 39 DI 10.1089/tmj.2010.0089 PG 5 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 784YO UT WOS:000292194800008 PM 21214304 ER PT S AU Mait, JN AF Mait, Joseph N. BE Angelsky, OV TI Toward a Mathematical Framework for Computational Imaging SO TENTH INTERNATIONAL CONFERENCE ON CORRELATION OPTICS SE Proceedings of SPIE LA English DT Proceedings Paper CT 10th International Conference on Correlation Optics CY SEP 12-16, 2011 CL Chernivtsi, UKRAINE SP Yuriy Fedkovych Chernivtsi Natl Univ, Opt Soc Amer (OSA), European Phys Soc (EPS), Int Commiss Opt (ICO), European Opt Soc (EOS), Rhythm Optoelect, Inc, Oculus Microsurg Clin Vash Zir, Defis Ltd, Privatbank, Rodnichok, Ltd, Arton Co, Off Aerospace Res & Dev, Air Force Off Sci Res, US Air Force Res Lab DE computational imaging; PSF engineering; multiplex measurements ID SYSTEMS; ARCHITECTURE; FIELDS AB I describe a framework useful for designing computational imaging systems and for assessing their efficacy and performance. I cast the problem as the design of a measurement matrix H followed by post-detection processing with an estimation matrix T. I consider only simple imaging as a vehicle to identify the framework and to motivate discussion. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Mait, JN (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 19 TC 0 Z9 0 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-995-1 J9 PROC SPIE PY 2011 VL 8338 AR 83380E DI 10.1117/12.915826 PG 8 WC Optics SC Optics GA BYF20 UT WOS:000298379300014 ER PT S AU Woolard, D Zhang, WD AF Woolard, Dwight Zhang, Weidong BE Sadwick, LP OSullivan, CMM TI THz Lasing Concepts Based Upon InAs/GaSb Broken-Gap Heterostructures SO TERAHERTZ TECHNOLOGY AND APPLICATIONS IV SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Terahertz Technology and Applications IV CY JAN 26-27, 2011 CL San Francisco, CA SP SPIE DE broken-gap heterostructure; THz lasing; resonant tunneling; heavy holes; interband tunneling; optical gain ID TRANSITIONS; LASER AB This paper will illustrate the potential of InAs/GaSb broken-gap structures for providing a solution to the well-known and long-standing terahertz (THz) frequency gap in source technology. In a double-barrier GaSb/InAs/GaSb heterostructure, the ultrafast heavy-hole interband tunneling can be utilized to achieve electron depopulation of a quasi-bound, heavy-hole level located in the valence-band of the right GaSb barrier region. A population inversion is then created using electron injection into the conduction-band resonant state of the double-barrier structure. Degrading nonradiative processes such as acoustic phonon, optical phonon and Auger recombination are suppressed in this spatially separated two-level energy system. Hence, heavy-hole interband tunneling prevails over nonradative transition rates and establishes a population inversion at relatively high operating temperatures. Detailed simulations predict a significant optical (total) gain of similar to 0.001 which is comparable with GaAs/AlGaAs quantum well laser in spite of the small overlap of conduction band and heavy-hole wavefunctions. The TE emission allows for implementation of vertical surface emission in large area, for single or arrayed devices. Also, lateral quantum confinement of arrayed systems can be used to reduce the conduction band current density (and undesired thermal heating) and increase the quantum efficiency. C1 [Woolard, Dwight] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Woolard, D (reprint author), USA, Res Off, Res Triangle Pk, NC 27709 USA. NR 14 TC 1 Z9 1 U1 0 U2 3 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-475-8 J9 PROC SPIE PY 2011 VL 7938 AR 79380C DI 10.1117/12.881254 PG 8 WC Optics; Physics, Applied SC Optics; Physics GA BYD22 UT WOS:000298083400012 ER PT J AU Michael, G AF Michael, George TI WMD Proliferation: Reforming the Security Sector to Meet the Threat SO TERRORISM AND POLITICAL VIOLENCE LA English DT Book Review C1 [Michael, George] USA, Force Counterproliferat Ctr, Maxwell Afb, AL USA. RP Michael, G (reprint author), USA, Force Counterproliferat Ctr, Maxwell Afb, AL USA. NR 1 TC 0 Z9 0 U1 1 U2 1 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0954-6553 J9 TERROR POLIT VIOLENC JI Terror. Polit. Violence PY 2011 VL 23 IS 3 BP 475 EP 477 AR PII 938290794 DI 10.1080/09546553.2011.581059 PG 3 WC International Relations; Political Science SC International Relations; Government & Law GA 772YJ UT WOS:000291273900011 ER PT J AU Michael, G AF Michael, George TI The Four Faces of Nuclear Terrorism SO TERRORISM AND POLITICAL VIOLENCE LA English DT Book Review C1 [Michael, George] USA, Force Counterproliferat Ctr, Maxwell Afb, AL USA. RP Michael, G (reprint author), USA, Force Counterproliferat Ctr, Maxwell Afb, AL USA. NR 1 TC 0 Z9 0 U1 1 U2 1 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0954-6553 J9 TERROR POLIT VIOLENC JI Terror. Polit. Violence PY 2011 VL 23 IS 3 BP 482 EP 485 AR PII 938292446 DI 10.1080/09546553.2011.581068 PG 4 WC International Relations; Political Science SC International Relations; Government & Law GA 772YJ UT WOS:000291273900018 ER PT J AU Michael, G AF Michael, George TI Ahmadinejad: The Secret History of Iran's Radical Leader SO TERRORISM AND POLITICAL VIOLENCE LA English DT Book Review C1 [Michael, George] USA, Force Counterproliferat Ctr, Maxwell Afb, AL USA. RP Michael, G (reprint author), USA, Force Counterproliferat Ctr, Maxwell Afb, AL USA. NR 1 TC 0 Z9 0 U1 1 U2 2 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0954-6553 J9 TERROR POLIT VIOLENC JI Terror. Polit. Violence PY 2011 VL 23 IS 3 BP 490 EP 492 AR PII 938289122 DI 10.1080/09546553.2011.581082 PG 3 WC International Relations; Political Science SC International Relations; Government & Law GA 772YJ UT WOS:000291273900022 ER PT B AU Cheng, G Mehta, N Oyler, K AF Cheng, G. Mehta, N. Oyler, K. BE Li, S Niu, P TI Green Primary Explosives SO THEORY AND PRACTICE OF ENERGETIC MATERIALS (VOL IX), PROCEEDINGS OF THE 2011 INTERNATIONAL AUTUMN SEMINAR ON PROPELLANTS, EXPLOSIVES AND PYROTECHNICS LA English DT Proceedings Paper CT 9th International Autumn Seminar on Propellants, Explosives and Pyrotechnics CY SEP 20-23, 2011 CL Nanjing, PEOPLES R CHINA SP China Ordinance Soc, Beijing Inst Technol, Hubei Inst Aerosp Chemotechnol, CAEP, Inst Chem Mat, Shaanxi Appl Phys Chem Res Inst, Sci & Technol Appl Phys Chem Lab, Internal Flow & Thermo Structure Lab, Sci & Technol Combust, Nanjing Univ Sci & Technol, N Univ China DE primary explosives; green materials; triazine triazide; DBX AB Primary explosives are essential components of primers and detonators, which are responsible for initiating military items ranging from small caliber munitions to warheads. The most common primary explosives in widespread use are lead azide and lead styphnate. Lead azide is used as a neat material in detonator transfer charges or in initiating mixes. Lead styphnate is mostly used in primer formulations, although it is found in detonator stab mixes as well. Lead is both an acute and chronic toxin, and the human body has difficulty in removing it once it has, been absorbed and dissolved in the blood. Consequently, a main concern is the absorption of lead by humans from exposure to initiating mix constituents, as well as the combustion by-products of lead based compositions. As a result, there is a major effort to overcome these toxicity issues through development of green, low toxicity primary materials as neat compounds or in formulations. Altemative, green materials are being explored with a focus on the use of heterocyclic, high-nitrogen organic compounds in addition to other inorganic systems. High nitrogen molecules rely on large positive heats of formation for their energetic content and decompose primarily into non-toxic nitrogen gas with minimal solid products. To date, several metal salts based on nitriminotetrazoles, as well as polyazides have been tested. Materials such as triazine triazide and DBX-I have shown promise and have been tested as stab mix and primer mix formulations. The goal is to develop green formulations and optimize energetic performance as well as minimize impact sensitivity. C1 [Cheng, G.; Mehta, N.; Oyler, K.] US Army, Explos Dev Branch, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Cheng, G (reprint author), US Army, Explos Dev Branch, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. NR 15 TC 0 Z9 0 U1 0 U2 0 PU SCIENCE PRESS BEIJING PI BEIJING PA 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100707, PEOPLES R CHINA BN 978-7-03-032045-2 PY 2011 BP 949 EP 953 PG 5 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA BG7BQ UT WOS:000391156800183 ER PT J AU Guerrero, AF Guerrero, KT Shakir, KMM AF Guerrero, Arthur F. Guerrero, Karen T. Shakir, K. M. Mohamed TI Thyroid Protection Gone Awry: lododerma Following Potassium Iodide Administration Prior to Metaiodobenzylguanidine Scintigraphy SO THYROID LA English DT Letter ID IODODERMA C1 [Guerrero, Arthur F.] Tripler Army Med Ctr, Dept Endocrinol, Tripler, HI 96819 USA. [Guerrero, Karen T.] Tripler Army Med Ctr, Dept Dermatol, Tripler, HI 96819 USA. [Shakir, K. M. Mohamed] Natl Naval Med Ctr, Dept Endocrinol, Bethesda, MD USA. RP Guerrero, AF (reprint author), Tripler Army Med Ctr, Dept Endocrinol, Jarret White Rd, Tripler, HI 96819 USA. EM arthur.f.guerrero@gmail.com NR 5 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1050-7256 J9 THYROID JI Thyroid PD JAN PY 2011 VL 21 IS 1 BP 93 EP 94 DI 10.1089/thy.2009.0467 PG 2 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 710VI UT WOS:000286544700017 PM 21162686 ER PT J AU Chinella, JF AF Chinella, John F. GP TMS TI MODELING PERFORMANCE OF PROTECTION MATERIALS ALUMINUM 7020-T651 AND RHA STEEL SO TMS2011 SUPPLEMENTAL PROCEEDINGS, VOL 2: MATERIALS FABRICATION, PROPERTIES, CHARACTERIZATION, AND MODELING LA English DT Proceedings Paper CT TMS 140th Annual Meeting and Exhibition CY FEB 27-MAR 03, 2011 CL San Diego, CA SP TMS DE Aluminum; 7020; Steel; RHA; Protection Materials; Regression; Modeling AB Test-protection levels of 7020-T651, are compared to a modern Rolled Homogeneous Armor (RHA) and to RHA data with regression and statistics of RHA protection level mean response, confidence intervals, and cumulative probability distributions. Test-evaluations of aluminum 7020-T651 suggest it may serve as a low-cost substitute for rolled homogeneous armor steel (RHA), with improved levels of protection from armor-piercing projectiles and fragments. Alloy 7020-T651 fragment protection weight savings of 30% to 44% and armor piercing protection weight savings of 16% over RHA may be achieved, along with damage tolerance, minimal need for spall liners, and potential for equal or improved structural stiffness. Revision of specifications MIL-DTL-46063 for 7020, and MIL-DTL-12560 for RHA, in requirements/corrections of chemistry, microstructure, and failure modes, may improve standards of protection-level, and the system capabilities of fabricability or repair, reduction of weight and cost, scope of application, and extreme climate durability. C1 US Army Res Lab, RDRL WMM F, Aberdeen Proving Ground, MD 21005 USA. RP Chinella, JF (reprint author), US Army Res Lab, RDRL WMM F, Aberdeen Proving Ground, MD 21005 USA. NR 16 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER, W SUSSEX PO 19 8SQ, ENGLAND BN 978-1-11802-946-6 PY 2011 BP 221 EP 228 PG 8 WC Materials Science, Multidisciplinary SC Materials Science GA BHY36 UT WOS:000327013200028 ER PT J AU Shih, TM Guarisco, JA Myers, TM Kan, RK McDonough, JH AF Shih, Tsung-Ming Guarisco, John A. Myers, Todd M. Kan, Robert K. McDonough, John H. TI The oxime pro-2-PAM provides minimal protection against the CNS effects of the nerve agents sarin, cyclosarin, and VX in guinea pigs SO TOXICOLOGY MECHANISMS AND METHODS LA English DT Article ID 2-WAY SHUTTLEBOX AVOIDANCE; BLOOD-BRAIN-BARRIER; N-METHYLPYRIDINIUM-2-CARBALDOXIME CHLORIDE; BIOLOGICAL-MEMBRANES; IMPROVED DELIVERY; INDUCED SEIZURES; PRO-DRUG; N-METHYL-1,6-DIHYDROPYRIDINE-2-CARBALDOXIME HYDROCHLORIDE; SOMAN; ORGANOPHOSPHORUS AB This study examined whether pro-2-PAM, a pro-drug dihydropyridine derivative of the oxime 2-pralidoxime (2-PAM) that can penetrate the brain, could prevent or reverse the central toxic effects of three nerve agents; sarin, cyclosarin, and VX. The first experiment tested whether pro-2-PAM could reactivate guinea pig cholinesterase (ChE) in vivo in central and peripheral tissues inhibited by these nerve agents. Pro-2-PAM produced a dose-dependent reactivation of sarin- or VX-inhibited ChE in both peripheral and brain tissues, but with substantially greater reactivation in peripheral tissues compared to brain. Pro-2-PAM produced 9-25% reactivation of cyclosarin-inhibited ChE in blood, heart, and spinal cord, but no reactivation in brain or muscle tissues. In a second experiment, the ability of pro-2-PAM to block or terminate nerve agent-induced electroencephalographic seizure activity was evaluated. Pro-2-PAM was able to block sarin- or VX-induced seizures (16-33%) over a dose range of 24-32 mg/kg, but was ineffective against cyclosarin-induced seizures. Animals that were protected from seizures showed significantly less weight loss and greater behavioral function 24 h after exposure than those animals that were not protected. Additionally, brains were free from neuropathology when pro-2-PAM prevented seizures. In summary, pro-2-PAM provided modest reactivation of sarin- and VX-inhibited ChE in the brain and periphery, which was reflected by a limited ability to block or terminate seizures elicited by these agents. Pro-2-PAM was able to reactivate blood, heart, and spinal cord ChE inhibited by cyclosarin, but was not effective against cyclosarin-induced seizures.= 1 pill per week in the austere setting. Continuous users were nearly twice as compliant as conventional users (p = .019) and compliant OCP users reported significantly less menstrual burden than noncompliant users (p = .017). Almost all women (85%) desired mandatory education about menstrual suppression through OCPs. Conclusion: Despite OCP experience and desire for amenorrhea, prevalence of extended cycle OCP use in this population is low. Extended OCPs users in the austere setting report improved compliance and reduced menstrual burden compared with conventional users. Education about OCPs is highly desirable for most military women and may benefit those in austere settings. Copyright (C) 2011 by the Jacobs Institute of Women's Health. Published by Elsevier Inc. C1 [Powell-Dunford, Nicole C.; Deuster, Patricia A.] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA. [Powell-Dunford, Nicole C.] USA, Sch Aviat Med, Ft Rucker, AL USA. [Cuda, Amanda S.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Moore, Jeffrey L.] Naval Aeromed Inst, Pensacola, FL USA. [Crago, Mark S.] Womack Army Med Ctr, Fayetteville, NC USA. [Crago, Mark S.] Uniformed Serv Univ Hlth Sci, Dept Family Med, Bethesda, MD 20814 USA. [Kelly, Amanda M.] USA, Aeromed Res Lab, Ft Rucker, AL USA. RP Powell-Dunford, NC (reprint author), 19 Diamond Circle, Ft Rucker, AL 36362 USA. EM Dunford.powell@us.army.mil RI Deuster, Patricia/G-3838-2015 OI Deuster, Patricia/0000-0002-7895-0888 NR 29 TC 13 Z9 13 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1049-3867 J9 WOMEN HEALTH ISS JI Womens Health Iss. PD JAN-FEB PY 2011 VL 21 IS 1 BP 86 EP 91 DI 10.1016/j.whi.2010.08.006 PG 6 WC Public, Environmental & Occupational Health; Women's Studies SC Public, Environmental & Occupational Health; Women's Studies GA 707LQ UT WOS:000286288500012 PM 21185993 ER PT J AU Mattila, AM Crandall, BD Goldman, SB AF Mattila, Amy M. Crandall, Brian D. Goldman, Sarah B. TI US Army combat operational stress control throughout the deployment cycle: A case study SO WORK-A JOURNAL OF PREVENTION ASSESSMENT & REHABILITATION LA English DT Article DE Behavioral health; combat stress; deployment health ID MENTAL-HEALTH PROBLEMS; IRAQ; AFGHANISTAN; DISORDERS; MILITARY; SOLDIERS; WAR AB As military conflicts around the world persist, a comprehensive approach in managing behavioral health issues will continue to be a key component of military healthcare. Deployed military personnel frequently exposed to trauma are well-known to be at high risk for developing behavioral health disorders, including combat stress reactions and posttraumatic stress disorder. In the U.S. Army, members of combat operational stress control (COSC) units have unique skills to assist soldiers and their families not only throughout all phases of a deployment, but also throughout a soldier's entire career. The purposes of this article are twofold, first to describe the role of COSC operations with an emphasis on interventions in a deployed environment. The second purpose is to present a case study from Operation Iraqi Freedom highlighting the efficacy of the COSC approach to meet a Soldier's behavioral health needs in a deployed environment. C1 [Mattila, Amy M.; Crandall, Brian D.] 254th Combat Operat Stress Control Detachment, Miesau, Germany. [Goldman, Sarah B.] USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Mattila, AM (reprint author), USA, 6785 Kevin Dr, Bethel Pk, PA 15102 USA. EM amy.mattila@us.army.mil NR 19 TC 2 Z9 2 U1 2 U2 5 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 1051-9815 J9 WORK JI Work PY 2011 VL 38 IS 1 BP 13 EP 18 DI 10.3233/CBM-2011-1100 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 708QJ UT WOS:000286378800003 PM 21248416 ER PT J AU Dang, QF Yan, JQ Li, JJ Cheng, XJ Liu, CS Chen, XG AF Dang, Qi Feng Yan, Jing Quan Li, Jing Jing Cheng, Xiao Jie Liu, Cheng Sheng Chen, Xi Guang TI Controlled gelation temperature, pore diameter and degradation of a highly porous chitosan-based hydrogel SO CARBOHYDRATE POLYMERS LA English DT Article DE Highly porous hydrogel; Gelation temperature; Pore diameter; Degradation behavior ID BETA-GLYCEROPHOSPHATE; THERMOSENSITIVE HYDROGEL; RHEOLOGICAL CHARACTERIZATION; SOLUTION BEHAVIOR; DELIVERY-SYSTEM; DRUGS; GELS; REGENERATION; CELLS AB In this study, highly porous chitosan-alpha,beta-glycerophosphate hydrogels were prepared by changing the chitosan/alpha,beta-glycerophosphate ratio. The gelation temperatures of these gels determined from rheological analysis indicated that the gelation temperature decreased by increasing alpha,beta-glycerophosphate content. The chemical structures and morphology of the hydrogels were examined by FTIR and SEM, respectively. The SEM images showed a highly porous 3D chitosan-alpha,beta-glycerophosphate hydrogel structure with interconnected pores and the pore diameters depended on the chitosan/alpha,beta-glycerophosphate ratio. The swelling and degradation experiments indicated that the degradation behaviors of these hydrogels via bulk erosion relied heavily on the chitosan/alpha,beta-glycerophosphate ratio. This study suggested that the gelation temperature, pore diameter and degradation behaviors of chitosan-based porous hydrogels can be controlled by changing the ratio of chitosan and alpha,beta-glycerophosphate. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Dang, Qi Feng; Li, Jing Jing; Cheng, Xiao Jie; Liu, Cheng Sheng; Chen, Xi Guang] Ocean Univ China, Coll Marine Life Sci, Qingdao 266003, Peoples R China. [Yan, Jing Quan] Seabeau Cosmet Co Ltd, Engineer Res & Dev Ctr, Qingdao 266111, Peoples R China. RP Chen, XG (reprint author), Ocean Univ China, Coll Marine Life Sci, 5 Yushan Rd, Qingdao 266003, Peoples R China. EM xgchen@ouc.edu.cn NR 30 TC 31 Z9 34 U1 3 U2 39 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0144-8617 J9 CARBOHYD POLYM JI Carbohydr. Polym. PD JAN 1 PY 2011 VL 83 IS 1 BP 171 EP 178 DI 10.1016/j.carbpol.2010.07.038 PG 8 WC Chemistry, Applied; Chemistry, Organic; Polymer Science SC Chemistry; Polymer Science GA 675DH UT WOS:000283805600023 ER PT J AU Gadhari, NS Sanghavi, BJ Karna, SP Srivastava, AK AF Gadhari, Nayan S. Sanghavi, Bankim J. Karna, Shashi P. Srivastava, Ashwini K. TI Potentiometric stripping analysis of bismuth based on carbon paste electrode modified with cryptand [2.2.1] and multiwalled carbon nanotubes SO ELECTROCHIMICA ACTA LA English DT Article DE Bismuth; Cryptand [2.2.1]; Multiwalled carbon nanotubes; Potentiometric stripping analysis ID CHEMICALLY-MODIFIED ELECTRODES; VOLTAMMETRIC DETERMINATION; MACROCYCLIC-COMPOUNDS; CHLORIDE MEDIA; COPPER; BI(III); LEAD; SPECTROMETRY; COMPLEXES; OXIDATION AB An electrochemical method based on potentiometric stripping analysis (PSA) employing a cryptand [2.2.1] (CRY) and carbon nanotube (CNT) modified paste electrode (CRY-CNT-PE) has been proposed for the sub-nanomolar determination of bismuth. The characterization of the electrode surface has been carried out by means of scanning electron microscopy (SEM), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and chronocoulometry (CC). It was observed that by employing CRY-CNT-PE, a 9-fold enhancement in the PSA signal (dt/dE) was observed as compared to plain carbon paste electrode (PCPE). Under the optimized conditions, dt/dE (s/V) was proportional to the Bi(111) concentration in the range of 5.55 x 10(-8) to 9.79 x 10(-11) M (r = 0.9990) with the detection limit (S/N = 3) of 3.17 x 10(-11) M. The practical analytical utilities of the modified electrode were demonstrated by the determination of bismuth in pharmaceutical formulations, human hair, sea water, urine and blood serum samples. The prepared modified electrode showed several advantages, such as a simple preparation method, high sensitivity, very low detection limits and excellent reproducibility. Moreover, the results obtained for bismuth analysis in commercial and real samples using CRY-CNT-PE and those obtained by atomic absorption spectroscopy (AAS) are in agreement at the 95% confidence level. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Gadhari, Nayan S.; Sanghavi, Bankim J.; Srivastava, Ashwini K.] Univ Bombay, Dept Chem, Bombay 400098, Maharashtra, India. [Karna, Shashi P.] USA, Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA. RP Srivastava, AK (reprint author), Univ Bombay, Dept Chem, Bombay 400098, Maharashtra, India. EM aksrivastava@chem.mu.ac.in FU US Army International Technology Center, Pacific Asia Countries [FA5209-09-P-0202] FX This research was funded by the US Army International Technology Center, Pacific Asia Countries through contract number FA5209-09-P-0202. The authors express their sincere thanks to Dr. M. Sudersanan for his interest and valuable suggestions. NR 38 TC 48 Z9 49 U1 1 U2 23 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0013-4686 J9 ELECTROCHIM ACTA JI Electrochim. Acta PD DEC 30 PY 2010 VL 56 IS 2 BP 627 EP 635 DI 10.1016/j.electacta.2010.09.100 PG 9 WC Electrochemistry SC Electrochemistry GA 692TL UT WOS:000285177900001 ER PT J AU Michael, NL AF Michael, Nelson L. TI Oral Preexposure Prophylaxis for HIV -- Another Arrow in the Quiver?. SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Editorial Material ID RANDOMIZED CONTROLLED-TRIAL; MALE CIRCUMCISION; INFECTION; TRANSMISSION; PREVENTION; REDUCTION; MEN C1 US Mil HIV Res Program, Div Retrovirol, Walter Reed Army Inst Res, Rockville, MD USA. RP Michael, NL (reprint author), US Mil HIV Res Program, Div Retrovirol, Walter Reed Army Inst Res, Rockville, MD USA. NR 12 TC 17 Z9 18 U1 0 U2 0 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD DEC 30 PY 2010 VL 363 IS 27 BP 2663 EP 2665 DI 10.1056/NEJMe1012929 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 700SD UT WOS:000285763700013 PM 21091280 ER PT J AU Keasey, S Pugh, C Tikhonov, A Chen, GX Schweitzer, B Nalca, A Ulrich, RG AF Keasey, Sarah Pugh, Christine Tikhonov, Alexander Chen, Gengxin Schweitzer, Barry Nalca, Aysegul Ulrich, Robert G. TI Proteomic Basis of the Antibody Response to Monkeypox Virus Infection Examined in Cynomolgus Macaques and a Comparison to Human Smallpox Vaccination SO PLOS ONE LA English DT Article ID HUMAN IMMUNE-RESPONSE; VACCINIA VIRUS; INTRACELLULAR MATURE; PROTECTION; PROTEINS; ANTIGENS; VIRION; CONGO AB Monkeypox is a zoonotic viral disease that occurs primarily in Central and West Africa. A recent outbreak in the United States heightened public health concerns for susceptible human populations. Vaccinating with vaccinia virus to prevent smallpox is also effective for monkeypox due to a high degree of sequence conservation. Yet, the identity of antigens within the monkeypox virus proteome contributing to immune responses has not been described in detail. We compared antibody responses to monkeypox virus infection and human smallpox vaccination by using a protein microarray covering 92-95% (166-192 proteins) of representative proteomes from monkeypox viral clades of Central and West Africa, including 92% coverage (250 proteins) of the vaccinia virus proteome as a reference orthopox vaccine. All viral gene clones were verified by sequencing and purified recombinant proteins were used to construct the microarray. Serum IgG of cynomolgus macaques that recovered from monkeypox recognized at least 23 separate proteins within the orthopox proteome, while only 14 of these proteins were recognized by IgG from vaccinated humans. There were 12 of 14 antigens detected by sera of human vaccinees that were also recognized by IgG from convalescent macaques. The greatest level of IgG binding for macaques occurred with the structural proteins F13L and A33R, and the membrane scaffold protein D13L. Significant IgM responses directed towards A44R, F13L and A33R of monkeypox virus were detected before onset of clinical symptoms in macaques. Thus, antibodies from vaccination recognized a small number of proteins shared with pathogenic virus strains, while recovery from infection also involved humoral responses to antigens uniquely recognized within the monkeypox virus proteome. C1 [Keasey, Sarah; Pugh, Christine; Nalca, Aysegul; Ulrich, Robert G.] USA, Med Res Inst Infect Dis, Frederick, MD USA. [Tikhonov, Alexander; Chen, Gengxin; Schweitzer, Barry] Life Technol, Carlsbad, CA USA. RP Keasey, S (reprint author), USA, Med Res Inst Infect Dis, Frederick, MD USA. EM rulrich@bioanalysis.org RI Tikhonov, Alexander/I-1453-2012 OI Tikhonov, Alexander/0000-0003-3808-9701 FU Joint Science and Technology Office [4.10017_06_RD, W81XWH-05-2-0077] FX Financial support was provided by funding from the Joint Science and Technology Office (4.10017_06_RD and W81XWH-05-2-0077). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 29 TC 12 Z9 12 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 30 PY 2010 VL 5 IS 12 AR e15547 DI 10.1371/journal.pone.0015547 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 701DD UT WOS:000285793600019 PM 21209900 ER PT J AU Vetter, O Becker, JM Merrifield, MA Pequignet, AC Aucan, J Boc, SJ Pollock, CE AF Vetter, O. Becker, J. M. Merrifield, M. A. Pequignet, A. -C. Aucan, J. Boc, S. J. Pollock, C. E. TI Wave setup over a Pacific Island fringing reef SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID CORAL-REEFS; FIELD OBSERVATIONS; NATURAL BEACH; WATER AB Measurements obtained across a shore-attached, fringing reef on the southeast coast of the island of Guam are examined to determine the relationship between incident waves and wave-driven setup during storm and nonstorm conditions. Wave setup on the reef flat correlates well (r > 0.95) and scales near the shore as approximately 35% of the incident root mean square wave height in 8 m water depth. Waves generated by tropical storm Man-Yi result in a 1.3 m setup during the peak of the storm. Predictions based on traditional setup theory (steady state, inviscid cross-shore momentum and depth-limited wave breaking) and an idealized model of localized wave breaking at the fore reef are in agreement with the observations. The reef flat setup is used to estimate a similarity parameter at breaking that is in agreement with observations from a steeply sloping sandy beach. A weak (similar to 10%) increase in setup is observed across the reef flat during wave events. The inclusion of bottom stress in the cross-shore momentum balance may account for a portion of this signal, but this assessment is inconclusive as the reef flat currents in some cases are in the wrong direction to account for the increase. An independent check of fringing reef setup dynamics is carried out for measurements at the neighboring island of Saipan with good agreement. C1 [Vetter, O.; Merrifield, M. A.; Pequignet, A. -C.] Univ Hawaii Manoa, Dept Oceanog, Sch Ocean & Earth Sci & Technol, Honolulu, HI 96822 USA. [Aucan, J.] Bermuda Inst Ocean Sci, Biol Stn 17, St Georges Ge 01, Bermuda. [Becker, J. M.] Univ Hawaii Manoa, Dept Geol & Geophys, Sch Ocean & Earth Sci & Technol, Honolulu, HI 96822 USA. [Boc, S. J.; Pollock, C. E.] USA, Coastal & Hydraul Lab, Engineer Res Ctr, Vicksburg, MS 39180 USA. RP Vetter, O (reprint author), Univ Hawaii Manoa, Dept Oceanog, Sch Ocean & Earth Sci & Technol, Marine Sci Bldg,Suite 205,1000 Pope Rd, Honolulu, HI 96822 USA. EM jbecker@soest.hawaii.edu RI Pequignet, Christine/H-5618-2014; Aucan, Jerome/M-8378-2014 OI Aucan, Jerome/0000-0002-9883-0082 FU U.S. Army Corps of Engineers via a subcontract through UCSD; UCSD; USACE; National Oceanic and Atmospheric Administration [R/EP-31]; University of Hawaii; NOAA Office of Sea Grant, Department of Commerce [NA05OAR4171048] FX C. Kontoes, T. Hilmer, K. Millikan, and Y. Firing assisted with the Ipan field experiment. We also thank the staff at the University of Guam Marine Laboratory for their help during our field deployments and in particular Jason Miller for his invaluable contribution to the diving operation. J. Gove and colleagues at the Coral Reef Ecosystem Division of the NOAA National Marine Fisheries Service deployed and recovered sensors at Saipan. The wave buoy data were provided by the Coastal Data Information Program (CDIP) at the University of California, San Diego (UCSD). The project was funded by the U.S. Army Corps of Engineers via a subcontract through UCSD. Project support provided by J. Thomas (UCSD) and R. Jensen and A. Garcia (USACE) is greatly appreciated. This paper is funded in part (ACP) by a grant/cooperative agreement from the National Oceanic and Atmospheric Administration, Project R/EP-31, which is sponsored by the University of Hawaii Sea Grant College Program, SOEST, under Institutional grant NA05OAR4171048 from NOAA Office of Sea Grant, Department of Commerce. The views expressed herein are those of the authors and do not necessarily reflect the views of NOAA or any of its subagencies. UNIHI-SEAGRANT-JC-07-19. NR 26 TC 30 Z9 30 U1 1 U2 16 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9275 EI 2169-9291 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD DEC 28 PY 2010 VL 115 AR C12066 DI 10.1029/2010JC006455 PG 13 WC Oceanography SC Oceanography GA 701PS UT WOS:000285834800003 ER PT J AU Andreas, EL Jones, KF Fairall, CW AF Andreas, Edgar L. Jones, Kathleen F. Fairall, Christopher W. TI Production velocity of sea spray droplets SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID MARINE BOUNDARY-LAYER; DRY-DEPOSITION; WATER SURFACES; JET DROPS; AEROSOL CONCENTRATIONS; GENERATION FUNCTION; SIZE DISTRIBUTIONS; RELATIVE-HUMIDITY; PRODUCTION-RATES; SALT AEROSOL AB The sea spray generation function dF/dr(0) predicts the rate at which droplets of initial radius r(0) are produced at the sea surface. Because this function is not readily measurable in the marine environment, however, it is often inferred from measurements of the near-surface droplet concentration, C(r(0)), through an assumed velocity scale, the effective spray production velocity. This paper proceeds in reverse, though: It uses a reliable estimate of dF/dr(0) and 13 sets of measurements of C(r(0)) over the ocean to calculate the implied effective production velocity, V-eff, for droplets with initial radii r(0) from 5 to 300 mu m. It then compares these V-eff values with four candidate expressions for this production velocity: the dry-deposition velocity, V-Dh; the mean wind speed at the significant wave amplitude (A(1/3)), U-A1/3; the standard deviation in vertical droplet velocity, sigma(wd); and laboratory measurements of the ejection velocity of jet droplets, V-ej. The velocity scales U-A1/3 and V-ej agree best with the implied V-eff values for 20 <= r(0) <= 300 mu m. The deposition velocity, V-Dh, which is the velocity most commonly used in this application, agrees worst with the Veff values. For droplets with r(0) less than about 20 mu m, the analysis also rejects the main hypothesis: that dF/dr(0) and C(r(0)) can be related through a velocity scale. These smaller droplets simply have residence times that are too long for spray concentrations to be in local equilibrium with the spray production rate. C1 [Andreas, Edgar L.] NW Res Associates Inc, Seattle Div, Lebanon, NH 03766 USA. [Fairall, Christopher W.] NOAA, Earth Syst Res Lab, Div Phys Sci, Boulder, CO 80305 USA. [Jones, Kathleen F.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Andreas, EL (reprint author), NW Res Associates Inc, Seattle Div, 25 Eagle Rdg, Lebanon, NH 03766 USA. EM eandreas@nwra.com FU U.S. Mineral Management Service [M07RG13274]; U.S. Office of Naval Research [N00014-08-1-0411] FX We thank two anonymous reviewers for suggestions that helped clarify our presentation. The U.S. Mineral Management Service supported this work under Interagency Agreement M07RG13274. The U.S. Office of Naval Research also supported ELA through grant N00014-08-1-0411. NR 67 TC 14 Z9 14 U1 1 U2 13 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9275 EI 2169-9291 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD DEC 28 PY 2010 VL 115 AR C12065 DI 10.1029/2010JC006458 PG 16 WC Oceanography SC Oceanography GA 701PS UT WOS:000285834800004 ER PT J AU Folkes, PA AF Folkes, Patrick A. TI Correlated photon fluctuations at threshold of an interband cascade laser SO JOURNAL OF PHYSICS B-ATOMIC MOLECULAR AND OPTICAL PHYSICS LA English DT Article ID QUANTUM-THEORY; OPTICAL MASER; INDIRECT EXCITONS; RADIATION; WELLS; NOISE; COHERENCE; STATES; FIELD AB We report the observation of correlated photon fluctuations over a narrow range of current at threshold of an interband cascade laser using single-detector photon noise measurements. The correlated photon noise is manifested by large fluctuations in the low-frequency photon noise spectral density at certain discrete frequencies which are sensitive to the laser gain characteristics. We observe the concurrent emergence and growth of the lasing mode over the same current range indicating that the correlated photon noise provides evidence of the occurrence of a change in the photon fluctuation statistics and the onset of first-order coherence in the laser emission at threshold. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Folkes, PA (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM pfolkes@arl.army.mil NR 28 TC 0 Z9 0 U1 0 U2 2 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0953-4075 J9 J PHYS B-AT MOL OPT JI J. Phys. B-At. Mol. Opt. Phys. PD DEC 28 PY 2010 VL 43 IS 24 AR 245401 DI 10.1088/0953-4075/43/24/245401 PG 4 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA 688EV UT WOS:000284833500006 ER PT J AU Sturm, M Wagner, AM AF Sturm, Matthew Wagner, Anna M. TI Using repeated patterns in snow distribution modeling: An Arctic example SO WATER RESOURCES RESEARCH LA English DT Article ID PHYSICAL SNOATACK MODEL; ALPINE CATCHMENT; SEASONAL SNOW; AREAL DIFFERENTIATION; WATER EQUIVALENT; COVER PATTERNS; TERRAIN; SYSTEM; ALASKA; SIMULATIONS AB Snow distribution patterns are similar from one year to the next because they are largely controlled by the interaction of topography, vegetation, and consistent synoptic weather patterns. On a yearly basis none of these controls changes radically. As a consequence, deep and shallow areas of snow tend to be fixed in space, producing depth differences that may vary in absolute, but not relative, amounts from year to year. While this fact is widely known, the use of patterns in modeling snow cover distribution is limited. Here, on the basis of a training set of nine annual snow depth surveys from a small tundra basin in Alaska, we identify the climatological snow distribution pattern (CSDP). Using this and a few depth measurements, the snow distribution for years that were not included in the training set is predicted and mapped with a near-zero bias and RMSE that ranged from 4.4 to 10.4 cm. The accuracy of this strictly empirical approach to modeling the depth distribution is similar to, or better than, the output from a weather-driven physically based snow model. However, in our view a hybrid approach is best. Ingesting the CSDP into SnowModel, a widely used numerical code that simulates snow processes, the accuracy of the model output is improved by up to 60%. This hybrid approach retains the advantages of running a weather-driven numerical code but adds spatial accuracy currently only obtainable from observed snow patterns. The patterns can be captured in several ways, including aerial photography or satellite remote sensing during snowmelt. C1 [Sturm, Matthew; Wagner, Anna M.] USA, Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. RP Sturm, M (reprint author), USA, Cold Reg Res & Engn Lab, POB 35170, Ft Wainwright, AK 99703 USA. EM matthew.sturm@usace.army.mil FU NSF-OPP FX Glen Liston graciously supplied us with the code for SnowModel and coached us through several programming crises. The data for the model runs were supplied by the Water and Environmental Center at the University of Alaska. Carl Benson, Larry Hinzman, Jon Holmgren, Glen Liston, Eric Pyne, Chris Hiemstra, Art Gelvin, Stephanie Saari, Mark Serreze, Drew Slater, Sveta Berezovskaya, and Ken Tape all contributed to the snow depth data used here. Gunter Bloschl and Glen Liston provided valuable comments in improving this paper, as did three anonymous reviewers. Logistical support after 2000 was provided by the University of Alaska Toolik Lake Field Station. The work was supported by several NSF-OPP grants. NR 59 TC 33 Z9 33 U1 5 U2 18 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0043-1397 J9 WATER RESOUR RES JI Water Resour. Res. PD DEC 24 PY 2010 VL 46 AR W12549 DI 10.1029/2010WR009434 PG 15 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA 699CI UT WOS:000285641100001 ER PT J AU Pelz, JOW Chua, TC Esquivel, J Stojadinovic, A Doerfer, J Morris, DL Maeder, U Germer, CT Kerscher, AG AF Pelz, Joerg O. W. Chua, Terence C. Esquivel, Jesus Stojadinovic, Alexander Doerfer, Joerg Morris, David L. Maeder, Uwe Germer, Christoph-Thomas Kerscher, Alexander G. TI Evaluation of Best Supportive Care and Systemic Chemotherapy as Treatment Stratified according to the retrospective Peritoneal Surface Disease Severity Score (PSDSS) for Peritoneal Carcinomatosis of Colorectal Origin SO BMC CANCER LA English DT Article ID PERIOPERATIVE INTRAPERITONEAL CHEMOTHERAPY; RANDOMIZED PHASE-III; 1ST-LINE THERAPY; COLON-CANCER; OXALIPLATIN; FLUOROURACIL; BEVACIZUMAB; LEUCOVORIN; IRINOTECAN; CETUXIMAB AB Background: We evaluate the long-term survival of patients with peritoneal carcinomatosis (PC) treated with systemic chemotherapy regimens, and the impact of the of the retrospective peritoneal disease severity score (PSDSS) on outcomes. Methods: One hundred sixty-seven consecutive patients treated with PC from colorectal cancer between years 1987-2006 were identified from a prospective institutional database. These patients either received no chemotherapy, 5-FU/Leucovorin or Oxaliplatin/Irinotecan-based chemotherapy. Stratification was made according to the retrospective PSDSS that classifies PC patients based on clinically relevant factors. Survival analysis was performed using the Kaplan-Meier method and comparison with the log-rank test. Results: Median survival was 5 months (95% CI, 3-7 months) for patients who had no chemotherapy, 11 months (95% CI, 6-9 months) for patients treated with 5 FU/LV, and 12 months (95% CI, 4-20 months) for patients treated with Oxaliplatin/Irinotecan-based chemotherapy. Survival differed between patients treated with chemotherapy compared to those patients who did not receive chemotherapy (p = 0.026). PSDSS staging was identified as an independent predictor for survival on multivariate analysis [RR 2.8 (95% CI 1.5-5.4); p < 0.001]. Conclusion: A trend towards improved outcomes is demonstrated from treatment of patients with PC from colorectal cancer using modern systemic chemotherapy. The PSDSS appears to be a useful tool in patient selection and prognostication in PC of colorectal origin. C1 [Pelz, Joerg O. W.; Doerfer, Joerg; Maeder, Uwe; Germer, Christoph-Thomas; Kerscher, Alexander G.] Univ Wurzburg, Dept Gen Visceral & Paediat Surg, Wurzburg, Germany. [Chua, Terence C.; Morris, David L.] St George Hosp, UNSW Dept Surg, Sydney, NSW, Australia. [Esquivel, Jesus] St Agnes Hosp, Dept Surg Oncol, Baltimore, MD USA. [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Stojadinovic, Alexander] US Mil Canc Inst, Washington, DC USA. RP Pelz, JOW (reprint author), Univ Wurzburg, Dept Gen Visceral & Paediat Surg, Wurzburg, Germany. EM pelz_j@klinik.uni-wuerzburg.de RI Pelz, Joerg/D-6432-2011 FU St George Medical Research Foundation FX Dr. Terence C. Chua is a surgical oncology research scholar funded by the St George Medical Research Foundation. The other authors indicated no potential conflicts of interest. NR 19 TC 31 Z9 32 U1 0 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2407 J9 BMC CANCER JI BMC Cancer PD DEC 22 PY 2010 VL 10 AR 689 DI 10.1186/1471-2407-10-689 PG 12 WC Oncology SC Oncology GA 702IB UT WOS:000285886700001 PM 21176206 ER PT J AU Abranyos, Y Gumbs, G Fekete, P AF Abranyos, Yonatan Gumbs, Godfrey Fekete, Paula TI Spin-dependent scattering by a potential barrier on a nanotube SO JOURNAL OF PHYSICS-CONDENSED MATTER LA English DT Article ID COHERENT TRANSPORT; CARBON NANOTUBES AB The electron spin effects on the surface of a nanotube have been considered through the spin-orbit interaction (SOI), arising from the electron confinement on the surface of the nanotube. This is of the same nature as the Rashba-Bychkov SOI at a semiconductor heterojunction. We estimate the effect of disorder within a potential barrier on the transmission probability. Using a continuum model, we obtain analytic expressions for the spin-split energy bands for electrons on the surface of nanotubes in the presence of SOI. First we calculate analytically the amplitudes of scattering from a potential barrier located around the axis of the nanotube into spin-dependent states. The effect of disorder on the scattering process is included phenomenologically and induces a reduction in the transition probability. We analyze the relative role of SOI and disorder in the transmission probability which depends on the angular and linear momentum of the incoming particle, and its spin orientation. Finally we demonstrate that in the presence of disorder, perfect transmission may not be achieved for finite barrier heights. C1 [Abranyos, Yonatan; Gumbs, Godfrey] CUNY Hunter Coll, Dept Phys & Astron, New York, NY 10065 USA. [Fekete, Paula] US Mil Acad, West Point, PA USA. [Gumbs, Godfrey] Donostia Int Phys Ctr DIPC, San Sebastian 20018, Basque Country, Spain. RP Abranyos, Y (reprint author), CUNY Hunter Coll, Dept Phys & Astron, 695 Pk Ave, New York, NY 10065 USA. EM yabranyo@hunter.cuny.edu; ggumbs@hunter.cuny.edu; paula.fekete@usma.edu RI DONOSTIA INTERNATIONAL PHYSICS CTR., DIPC/C-3171-2014 FU AFRL [FA 9453-07-C-0207] FX This research was supported by contract # FA 9453-07-C-0207 of AFRL. NR 21 TC 2 Z9 2 U1 0 U2 5 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0953-8984 J9 J PHYS-CONDENS MAT JI J. Phys.-Condes. Matter PD DEC 22 PY 2010 VL 22 IS 50 AR 505304 DI 10.1088/0953-8984/22/50/505304 PG 9 WC Physics, Condensed Matter SC Physics GA 690ZK UT WOS:000285049200005 PM 21406795 ER PT J AU Connelly, BC Metcalfe, GD Shen, HE Wraback, M AF Connelly, Blair C. Metcalfe, Grace D. Shen, Hongen Wraback, Michael TI Direct minority carrier lifetime measurements and recombination mechanisms in long-wave infrared type II superlattices using time-resolved photoluminescence SO APPLIED PHYSICS LETTERS LA English DT Article ID AUGER RECOMBINATION; PHOTODIODES; PERFORMANCE AB We present a direct optical measurement of minority carrier lifetime as a function of temperature and excitation density in long-wave infrared InAs/GaSb type II superlattices using time-resolved photoluminescence. Results indicate that carrier lifetime is dominated by Shockley-Read-Hall recombination, with a lifetime of 30 ns at 77 K. Below 40 K, we observe a freeze-out of carriers and increased contributions from radiative recombination. High-injection measurements yield a radiative recombination coefficient of 1.8 x 10(-10) cm(3)/s and an upper limit of the Auger recombination coefficient of 10(-28) cm(6)/s at 60 K. An acceptor level of similar to 20 meV above the valence band is also determined. (C) 2010 American Institute of Physics. [doi:10.1063/1.3529458] C1 [Connelly, Blair C.; Metcalfe, Grace D.; Shen, Hongen; Wraback, Michael] USA, Res Lab, Sensors & Elect Devices Directorate, RDRL SEE M, Adelphi, MD 20783 USA. RP Connelly, BC (reprint author), USA, Res Lab, Sensors & Elect Devices Directorate, RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM blair.connelly@us.army.mil RI Schaff, William/B-5839-2009 FU Night Vision and Electronic Sensors Directorate; Missile Defense Agency; U.S. Army Research Laboratory FX The authors would like to thank S. Bandara and M. Tidrow for support and helpful discussions. Superlattice samples were grown by C. Hill at the Jet Propulsion Laboratory and obtained through the Strained Layer Superlattice Lifetime Measurements program funded by the Night Vision and Electronic Sensors Directorate and Missile Defense Agency. This research was supported in part by an appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities. NR 13 TC 70 Z9 70 U1 2 U2 24 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD DEC 20 PY 2010 VL 97 IS 25 AR 251117 DI 10.1063/1.3529458 PG 3 WC Physics, Applied SC Physics GA 700SJ UT WOS:000285764300017 ER PT J AU Peachman, KK Wieczorek, L Polonis, VR Alving, CR Rao, M AF Peachman, Kristina K. Wieczorek, Lindsay Polonis, Victoria R. Alving, Carl R. Rao, Mangala TI The effect of sCD4 on the binding and accessibility of HIV-1 gp41 MPER epitopes to human monoclonal antibodies SO VIROLOGY LA English DT Article DE Virus capture; Surface plasmon resonance; Soluble CD4; gp41; Monoclonal antibodies; HIV-1; Neutralization ID HUMAN-IMMUNODEFICIENCY-VIRUS; BROADLY NEUTRALIZING ANTIBODIES; VIRAL MEMBRANE-FUSION; SUBTYPE-B; ENVELOPE GLYCOPROTEIN; TYPE-1 HIV-1; SOLUBLE CD4; V3 LOOP; INTACT; INFECTION AB Two human monoclonal anti-HIV-1 antibodies, 2F5 and 4E10, were utilized to investigate the accessibility and conservation of gp41 MPER epitopes on five different clades of HIV-1 in the absence and presence of sCD4. The binding of human monoclonal antibodies (mAbs) to HIV-1 was dependent upon the virus clade. Soluble CD4 significantly increased the accessibility of gp41 MPER-binding epitopes on several isolates that previously showed little or no binding with 2F5 and 4E10 mAbs as determined by a modified ELISA-based virus capture assay and surface plasmon resonance. Studies on the relationship between virus binding and neutralization in a TZM-bl pseudovirus assay indicated that in most cases, mAbs that exhibited neutralization also bound the virus. However, neither binding per se nor the total envelope content per virion was a predictor of neutralization. The hidden or conformational gp41 MPER epitopes unmasked by sCD4 may provide additional targets for vaccine design. Published by Elsevier Inc. C1 [Rao, Mangala] US Mil HIV Res Program, Dept Adjuvant & Antigen Res, Div Retrovirol, Walter Reed Army Inst Res, Rockville, MD 20850 USA. [Peachman, Kristina K.; Wieczorek, Lindsay] Henry M Jackson Fdn Advancement Mil Med, Rockville, MD 20850 USA. RP Rao, M (reprint author), US Mil HIV Res Program, Dept Adjuvant & Antigen Res, Div Retrovirol, Walter Reed Army Inst Res, 1600 E Gude Dr, Rockville, MD 20850 USA. EM mrao@hivresearch.org FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DOD) [W81XWH-07-2-0067] FX We would like to thank James Tong and Vishant Ramadorai for their assistance with the surface plasmon resonance experiments. This work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD). NR 50 TC 8 Z9 8 U1 0 U2 5 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD DEC 20 PY 2010 VL 408 IS 2 BP 213 EP 223 DI 10.1016/j.virol.2010.09.029 PG 11 WC Virology SC Virology GA 681IK UT WOS:000284304400011 PM 20961591 ER PT J AU Courville, Z Horhold, M Hopkins, M Albert, M AF Courville, Zoe Hoerhold, Maria Hopkins, Mark Albert, Mary TI Lattice-Boltzmann modeling of the air permeability of polar firn SO JOURNAL OF GEOPHYSICAL RESEARCH-EARTH SURFACE LA English DT Article ID X-RAY MICROTOMOGRAPHY; NEAR-SURFACE FIRN; POROUS-MEDIA; GRAIN-SIZE; TRANSPORT-PROPERTIES; DRY-SNOW; MICROSTRUCTURE; METAMORPHISM; SANDSTONE; IMPACT AB Recent advances in three-dimensional (3D) imaging of snow and firn combined with numerical modeling of flow through complex geometries have greatly improved the ability to predict permeability values based on microstructure. In this work, we combined 3D reconstructions of polar firn microstructure obtained from microcomputed tomography (mu CT) and a 3D lattice-Boltzmann (LB) model of air flow. We compared the modeled results to measurements of permeability for polar firn with a wide range of grain and pore-scale characteristics. The results show good agreement between permeability measurements and calculated permeability values from the LB model over a wide range of sample types. The LB model is better at predicting measured permeability values than traditional empirical equations for polar firn. C1 [Courville, Zoe; Hopkins, Mark] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Albert, Mary] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. [Hoerhold, Maria] Alfred Wegener Inst Polar & Marine Sci, DE-27515 Bremerhaven, Germany. RP Courville, Z (reprint author), USA, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM zoe.r.courville@usace.army OI Albert, Mary/0000-0001-7842-2359 FU NSF [0125276, 9814676] FX This work was supported by NSF OPP grants 0125276 and 9814676. The authors would also like to thank Johannes Freitag of the Alfred Wegener Institute for help with the modeling, and Heinz Miller of the Alfred Wegener Institute for helping to fund some of the work. The helpful comments of the anonymous reviewers were greatly appreciated. NR 51 TC 11 Z9 11 U1 1 U2 14 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9003 EI 2169-9011 J9 J GEOPHYS RES-EARTH JI J. Geophys. Res.-Earth Surf. PD DEC 17 PY 2010 VL 115 AR F04032 DI 10.1029/2009JF001549 PG 11 WC Geosciences, Multidisciplinary SC Geology GA 696TN UT WOS:000285464400002 ER PT J AU Waxman, AJ Mink, PJ Devesa, SS Anderson, WF Weiss, BM Kristinsson, SY McGlynn, KA Landgren, O AF Waxman, Adam J. Mink, Pamela J. Devesa, Susan S. Anderson, William F. Weiss, Brendan M. Kristinsson, Sigurdur Y. McGlynn, Katherine A. Landgren, Ola TI Racial disparities in incidence and outcome in multiple myeloma: a population-based study SO BLOOD LA English DT Article ID UNDETERMINED SIGNIFICANCE MGUS; STEM-CELL TRANSPLANTATION; MONOCLONAL GAMMOPATHY; SOCIOECONOMIC-STATUS; PLUS DEXAMETHASONE; AFRICAN-AMERICAN; UNITED-STATES; SURVIVAL; RACE; CANCER AB Multiple myeloma (MM) is the most common hematologic malignancy in blacks. Some prior studies suggest inferior survival in blacks; others suggest similar survival. Using the original 9 Surveillance, Epidemiology, and End Results registries, we conducted a large-scale population-based study including 5798 black and 28 939 white MM patients diagnosed 1973-2005, followed through 2006. Age-adjusted incidence rates, disease-specific survival, and relative survival rates were calculated by race, age, and time period of diagnosis. Mean age at diagnosis was 65.8 and 69.8 years for blacks and whites, respectively (P < .001). Incidence among blacks was m twice that among whites; this disparity was greater among patients < 50 years (P = .002). Over the entire study period, disease-specific and relative survival rates were higher in blacks than whites (P < .001). For whites, 5-year relative survival rates increased significantly 1973-1993 to 1994-1998 (26.3% to 30.8%; P < .001) and 1994-1998 to 1999-2005 (30.8% to 35.0%; P = .004). Survival improvements among blacks were smaller and nonsignificant (1973-1993 to 1999-2005: 31.0% to 34.1%; P = .07). We found (1) a younger age of onset among blacks; (2) better survival in blacks 1973-2005; and (3) significant survival improvement among whites over time, with smaller, nonsignificant change seen among blacks, possibly due to unequal access to and/or disparate responsiveness to novel therapies. (Blood. 2010; 116(25): 5501-5506) C1 [Landgren, Ola] NCI, NIH, Ctr Canc Res, Med Oncol Branch, Bethesda, MD 20892 USA. [Mink, Pamela J.] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA. [Devesa, Susan S.; Anderson, William F.; McGlynn, Katherine A.] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. [Weiss, Brendan M.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Kristinsson, Sigurdur Y.] Karolinska Univ Hosp & Inst, Stockholm, Sweden. RP Landgren, O (reprint author), NCI, NIH, Ctr Canc Res, Med Oncol Branch, 9000 Rockville Pike,Bldg 10,Rm 13N240, Bethesda, MD 20892 USA. EM landgreo@mail.nih.gov RI Kristinsson, Sigurdur /M-2910-2015 OI Kristinsson, Sigurdur /0000-0002-4964-7476 FU NCI of the National Institutes of Health (NIH); NIH; Foundation for NIH; Pfizer Inc FX This work was supported by the Intramural Research Program of the NCI of the National Institutes of Health (NIH).; The authors declare no competing financial interests. A.J.W. is a member of the NIH Clinical Research Training Program, which is funded jointly by the NIH and the Foundation for NIH (in part by a grant from Pfizer Inc). NR 48 TC 88 Z9 89 U1 0 U2 3 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD DEC 16 PY 2010 VL 116 IS 25 BP 5501 EP 5506 DI 10.1182/blood-2010-07-298760 PG 6 WC Hematology SC Hematology GA 695PE UT WOS:000285383900013 PM 20823456 ER PT J AU Lin, JS Park, S Adamovicz, JJ Hill, J Bliska, JB Cote, CK Perlin, DS Amemiya, K Smiley, ST AF Lin, Jr-Shivan Park, Steven Adamovicz, Jeffrey J. Hill, Jim Bliska, James B. Cote, Christopher K. Perlin, David S. Amemiya, Kei Smiley, Stephen T. TI TNF alpha and IFN gamma contribute to F1/LcrV-targeted immune defense in mouse models of fully virulent pneumonic plague SO VACCINE LA English DT Article DE Yersinia pestis; Vaccine; Antibody; Cytokine ID YERSINIA-PESTIS INFECTION; NECROSIS-FACTOR-ALPHA; V-ANTIGEN; MONOCLONAL-ANTIBODIES; ACTIVE IMMUNIZATION; BIOLOGICAL WEAPON; BUBONIC PLAGUE; PROTECTS MICE; VACCINE; MACROPHAGES AB Immunization with the Yersinia pestis F1 and LcrV proteins improves survival in mouse and non-human primate models of pneumonic plague. F1- and LcrV-specific antibodies contribute to protection, however, the mechanisms of antibody-mediated defense are incompletely understood and serum antibody titers do not suffice as quantitative correlates of protection. Previously we demonstrated roles for tumor necrosis factor-alpha (TNF alpha) and gamma-interferon (IFN gamma) during defense against conditionally attenuated pigmentation (pgm) locus-negative Y. pestis. Here, using intranasal challenge with fully virulent pgm-positive Y. pestis strain CO92, we demonstrate that neutralizing TNF alpha and IFN gamma interferes with the capacity of therapeutically administered F1- or LcrV-specific antibody to reduce bacterial burden and increase survival. Moreover, using Y. pestis strain CO92 in an aerosol challenge model, we demonstrate that neutralizing TNF alpha and IFN gamma interferes with protection conferred by immunization with recombinant F1-LcrV fusion protein vaccine (p < 0.0005). These findings establish that TNF alpha and IFN gamma contribute to protection mediated by pneumonic plague countermeasures targeting F1 and LcrV, and suggest that an individual's capacity to produce these cytokines in response to Y. pestis challenge will be an important co-determinant of antibody-mediated defense against pneumonic plague. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Lin, Jr-Shivan; Smiley, Stephen T.] Trudeau Inst Inc, Saranac Lake, NY 12983 USA. [Park, Steven; Perlin, David S.] Univ Med & Dent New Jersey, New Jersey Med Sch, Publ Hlth Res Inst, Newark, NJ 07103 USA. [Adamovicz, Jeffrey J.] Midwest Res Inst, Frederick, MD 21702 USA. [Hill, Jim] Def Sci & Technol Lab, Porton Down SP4 0JQ, England. [Bliska, James B.] SUNY Stony Brook, Dept Mol Genet & Microbiol, Stony Brook, NY 11794 USA. [Cote, Christopher K.; Amemiya, Kei] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Smiley, ST (reprint author), Trudeau Inst Inc, 154 Algonquin Ave, Saranac Lake, NY 12983 USA. EM ssmiley@trudeauinstitute.org FU NIH [R01-AI61577-Smiley]; Northeast Biodefense Center Animal Core at PHRI (Perlin) [U54-AI057158-Lipkin]; Joint Science and Technology Office/Defense Threat Reduction Agency [TMTI10049_09_RT_T] FX We wish to acknowledge the technical assistance and expertise of Svetlana Senina, Guillaume Delmas, Enriko Dolgov, Jennifer L Dankmeyer, Michael M. Wormald, Steven Tobery, Anthony Bassett, Lawrence W. Kummer, and Frank M. Szaba. This work was supported by funding from the NIH to Trudeau Institute (R01-AI61577-Smiley) and the Northeast Biodefense Center (U54-AI057158-Lipkin) Animal Core at PHRI (Perlin), along with funding from the Joint Science and Technology Office/Defense Threat Reduction Agency (project number TMTI10049_09_RT_T). NR 50 TC 21 Z9 24 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD DEC 16 PY 2010 VL 29 IS 2 BP 357 EP 362 DI 10.1016/j.vaccine.2010.08.099 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 717OM UT WOS:000287057300025 PM 20840834 ER PT J AU Mantey, K Shams, S Nayfeh, MH Nayfeh, O Alhoshan, M Alrokayan, S AF Mantey, Kevin Shams, Somayeh Nayfeh, Munir H. Nayfeh, Osama Alhoshan, Mansour Alrokayan, Salman TI Synthesis of wirelike silicon nanostructures by dispersion of silicon on insulator using electroless etching SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID CHEMICAL-VAPOR-DEPOSITION; LIQUID-SOLID REACTION; LASER-ABLATION; BUILDING-BLOCKS; SI NANOWIRES; NANOTUBES; GROWTH; DEVICES; FABRICATION AB We employ electroless etching to disperse silicon on insulator (SOI) wafers in ionic silver HF into wirelike silicon nanostructures. The procedure allows detachment of the nanowires at the oxide interface and enables easy recovery of dispersions for subsequent controlled delivery. Nanowires 10 mu m long and 50-100 nm thick are demonstrated using an SOI substrate of 10 mu m device thickness. Direct material analysis shows no silver contamination after a wet-etch silver clean. Anodization treatment of the wires was conducted. Our measurements and analysis show that the wires are not amenable to anodization resulting from the fact that the nanowire radius is less than the thickness of depletion layer. The procedure has the potential of providing dispersions of arbitrarily long wirelike nanostructures which are useful for composite and energy applications. (C) 2010 American Institute of Physics. [doi:10.1063/1.3520437] C1 [Mantey, Kevin; Shams, Somayeh; Nayfeh, Munir H.] Univ Illinois, Dept Phys, Urbana, IL 61801 USA. [Nayfeh, Osama] USA, Res Lab, Adelphi, MD 20783 USA. [Alhoshan, Mansour; Alrokayan, Salman] King Saud Univ, King Abdullah Inst Nanotechnol, Riyadh, Saudi Arabia. RP Mantey, K (reprint author), Univ Illinois, Dept Phys, 1110 W Green St, Urbana, IL 61801 USA. EM m-nayfeh@uiuc.edu OI Nayfeh, Munir Hasan/0000-0002-1459-4976 FU ERDC-CERL; University of Illinois at Urbana-Champaign; Centre of Excellence in Biotechnology Research of King Saud University [CEBR 02] FX This work was supported partially by the ERDC-CERL, the University of Illinois at Urbana-Champaign, and the Centre of Excellence in Biotechnology Research of King Saud University, research Project No. CEBR 02. NR 33 TC 0 Z9 0 U1 3 U2 24 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD DEC 15 PY 2010 VL 108 IS 12 AR 124321 DI 10.1063/1.3520437 PG 4 WC Physics, Applied SC Physics GA 700UC UT WOS:000285768800114 ER PT J AU Bekhash, A Saini, J Li, X Rapuri, P Hooke, JA Kovatich, AJ Mural, RJ Shriver, CD Hu, H AF Bekhash, A. Saini, J. Li, X. Rapuri, P. Hooke, J. A. Kovatich, A. J. Mural, R. J. Shriver, C. D. Hu, H. TI Ethnicity Difference of Benign Breast Diseases in Breast Cancer and Non-Cancer Patients SO CANCER RESEARCH LA English DT Meeting Abstract C1 Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. MDR Global LLC, Windber, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD DEC 15 PY 2010 VL 70 SU 24 MA P3-13-02 DI 10.1158/0008-5472.SABCS10-P3-13-02 PG 1 WC Oncology SC Oncology GA V43QL UT WOS:000209695801284 ER PT J AU Ellsworth, RE Valente, AL Field, LA Kane, JL Love, B Tafra, L Shriver, CD AF Ellsworth, R. E. Valente, A. L. Field, L. A. Kane, J. L. Love, B. Tafra, L. Shriver, C. D. TI Genetic Signature Discriminating Metastatic from Non-Metastatic Small Tumors SO CANCER RESEARCH LA English DT Meeting Abstract C1 Henry M Jackson Fdn, Windber, PA USA. Windber Res Inst, Windber, PA USA. BioReka, Lutherville Timonium, MD USA. Anne Arundel Med Ctr, Annapolis, MD USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD DEC 15 PY 2010 VL 70 SU 24 MA P4-06-09 DI 10.1158/0008-5472.SABCS10-P4-06-09 PG 1 WC Oncology SC Oncology GA V43QL UT WOS:000209695801374 ER PT J AU Ellsworth, RE Deyarmin, B Patney, HL Shriver, CD Ellison, K Thornton, JD Dang, H Tafra, L Cheng, Z Rosman, M AF Ellsworth, R. E. Deyarmin, B. Patney, H. L. Shriver, C. D. Ellison, K. Thornton, J. D. Dang, H. Tafra, L. Cheng, Z. Rosman, M. TI Genetic Discrimination of Aggressive from Indolent DCIS SO CANCER RESEARCH LA English DT Meeting Abstract C1 Henry M Jackson Fdn, Windber, PA USA. Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Almac Diagnost, Durham, NC USA. Anne Arundel Med Ctr, Annapolis, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD DEC 15 PY 2010 VL 70 SU 24 MA P6-04-10 DI 10.1158/0008-5472.SABCS10-P6-04-10 PG 1 WC Oncology SC Oncology GA V43QL UT WOS:000209695800232 ER PT J AU Field, LA Rummel, S Shriver, CD Ellsworth, RE AF Field, L. A. Rummel, S. Shriver, C. D. Ellsworth, R. E. TI The Role of PSPHL in Breast Cancer in African American Women SO CANCER RESEARCH LA English DT Meeting Abstract C1 Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Henry M Jackson Fdn Adv Mil Med, Windber, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD DEC 15 PY 2010 VL 70 SU 24 MA P3-13-04 DI 10.1158/0008-5472.SABCS10-P3-13-04 PG 1 WC Oncology SC Oncology GA V43QL UT WOS:000209695801286 ER PT J AU Kopco, RL Lida, J Lehman, JR Somiari, S Somiari, R Mural, RJ Shriver, CD AF Kopco, R. L. Lida, J. Lehman, J. R. Somiari, S. Somiari, R. Mural, R. J. Shriver, C. D. TI Development of DNA Aptamers That Inhibit Invasion, Migration, and Growth of Breast Cancer Cells SO CANCER RESEARCH LA English DT Meeting Abstract C1 Windber Res Inst, Windber, PA USA. ITSI Biosci, Johnstown, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD DEC 15 PY 2010 VL 70 SU 24 MA PD02-08 DI 10.1158/0008-5472.SABCS10-PD02-08 PG 1 WC Oncology SC Oncology GA V43QL UT WOS:000209695801481 ER PT J AU Mittendorf, EA Perez, SA Tzonis, P Clifton, GT Ardavanis, A Holmes, JP Lekka, E Baxevanis, CN Ponniah, B Peoples, GE Papamichail, M AF Mittendorf, E. A. Perez, S. A. Tzonis, P. Clifton, G. T. Ardavanis, A. Holmes, J. P. Lekka, E. Baxevanis, C. N. Ponniah, B. Peoples, G. E. Papamichail, M. TI Combination Immunotherapy for Breast Cancer Patients: Safety and Immunologic Data from a Phase II Trial Administering a HER2/neu-Derived Peptide vaccine (AE37+GM-CSF) Sequentially or Concurrently with Trastuzumab in the Adjuvant Setting SO CANCER RESEARCH LA English DT Meeting Abstract C1 Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. St Savas Canc Hosp, Athens, Greece. Brooke Army Med Ctr, San Antonio, TX USA. Naval Med Ctr San Diego, San Diego, CA USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD DEC 15 PY 2010 VL 70 SU 24 MA P2-20-03 DI 10.1158/0008-5472.SABCS10-P2-20-03 PG 1 WC Oncology SC Oncology GA V43QL UT WOS:000209695801167 ER PT J AU Saini, J Li, X Kvecher, L Larson, C Croft, D Yang, YC Hooke, JA Shriver, CD Mural, RJ Hu, H AF Saini, J. Li, X. Kvecher, L. Larson, C. Croft, D. Yang, Y-C Hooke, J. A. Shriver, C. D. Mural, R. J. Hu, H. TI Differential Gene Expression Analysis among Post-Menopausal Caucasian Invasive Breast Cancer, Benign and Normal Subjects SO CANCER RESEARCH LA English DT Meeting Abstract C1 Windber Res Inst, Wndber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD DEC 15 PY 2010 VL 70 SU 24 MA P3-01-04 DI 10.1158/0008-5472.SABCS10-P3-01-04 PG 1 WC Oncology SC Oncology GA V43QL UT WOS:000209695801172 ER PT J AU Vreeland, TJ Clifton, GT Patil, R Clive, KS Sears, AK Holmes, JP Mittendorf, EA Ponniah, S Peoples, GE AF Vreeland, T. J. Clifton, G. T. Patil, R. Clive, K. S. Sears, A. K. Holmes, J. P. Mittendorf, E. A. Ponniah, S. Peoples, G. E. TI Safety and Clinical Efficacy of Multiple Booster Inoculations with the E75 Adjuvant Breast Cancer Vaccine SO CANCER RESEARCH LA English DT Meeting Abstract C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. Windber Med Ctr, Windber, PA USA. Naval Med Ctr San Diego, San Diego, CA USA. Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. Uniformed Serv Univ Hlth Sci, US Mil Canc Inst, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD DEC 15 PY 2010 VL 70 SU 24 MA P2-20-01 DI 10.1158/0008-5472.SABCS10-P2-20-01 PG 1 WC Oncology SC Oncology GA V43QL UT WOS:000209695801165 ER PT J AU Bethell, D Se, Y Lon, C Socheat, D Saunders, D Teja-Isavadharm, P Khemawoot, P Darapiseth, S Lin, J Sriwichai, S Kuntawungin, W Surasri, S Lee, SJ Sarim, S Tyner, S Smith, B Fukuda, MM AF Bethell, Delia Se, Youry Lon, Chanthap Socheat, Duong Saunders, David Teja-Isavadharm, Paktiya Khemawoot, Phisit Darapiseth, Sea Lin, Jessica Sriwichai, Sabaithip Kuntawungin, Worachet Surasri, Sittidech Lee, Sue J. Sarim, Ses Tyner, Stuart Smith, Bryan Fukuda, Mark M. TI Dose-Dependent Risk of Neutropenia after 7-Day Courses of Artesunate Monotherapy in Cambodian Patients with Acute Plasmodium falciparum Malaria SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID ARTEMISININ DERIVATIVES AB Background. Fears of emerging artemisinin resistance in western Cambodia have prompted a series of clinical trials investigating whether slow responses to antimalarial treatment can be overcome by increasing doses of drug. Methods. Patients with uncomplicated malaria were allocated 1 of 3 oral artesunate monotherapy regimens (2, 4, or 6 mg/kg/day for 7 days) and were observed for 42 days. A series of safety measures, including complete blood count on days 0, 3, 6, and 14, was implemented because of a lack of safety data for these experimental doses. Results. After 3 doses, geometric mean absolute neutrophil counts were reduced in all groups, and 2 patients required artesunate to be discontinued because of neutropenia (absolute neutrophil count, <1.0 x 10(3) cells/mL). Recipients of the 6 mg/kg/day dosage had significantly lower geometric mean absolute neutrophil counts than did recipients of the 2 and 4 mg/kg/day dosages at 6 and 14 days (P < .001 for each). Overall, 5 (19%) of 26 patients who received the 6 mg/kg/day dosage became neutropenic within 14 days, triggering a cohort-halting rule and ending the trial early. Pharmacokinetic data from neutropenic patients showed wide variance, with plasma clearance occurring significantly slower in neutropenic patients than in nonneutropenic patients. Conclusions. Artesunate remains a crucial drug for the treatment of malaria, and determining optimal dosing regimens is vital to overcome emerging resistant parasite strains along the Thai-Cambodian border. However, future experimental dosing studies must be designed with care, because the safety of such regimens can no longer be assumed. The artemisinin derivatives remain one of the safest classes of antimalarial drugs, but this study demonstrates that the dosing limit may have been reached. C1 [Bethell, Delia; Se, Youry; Lon, Chanthap; Saunders, David; Teja-Isavadharm, Paktiya; Khemawoot, Phisit; Lin, Jessica; Sriwichai, Sabaithip; Kuntawungin, Worachet; Surasri, Sittidech; Tyner, Stuart; Smith, Bryan; Fukuda, Mark M.] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. [Socheat, Duong; Darapiseth, Sea] Ctr Parasitol Entomol & Malaria Control, Pnom Penh, Cambodia. [Sarim, Ses] Tasanh Hlth Ctr, Samlot, Cambodia. [Lee, Sue J.] Mahidol Oxford Res Unit, Bangkok, Thailand. RP Bethell, D (reprint author), Armed Forces Res Inst Med Sci, Dept Immunol & Med, 315-6 Rajavithi Rd, Bangkok 10400, Thailand. EM delia.bethell@afrims.org RI Valle, Ruben/A-7512-2013 FU Bill and Melinda Gates Foundation through the World Health Organization; US Department of Defense; Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok, Thailand FX This study was funded by a Bill and Melinda Gates Foundation Program Grant through the World Health Organization, and the US Department of Defense Global Emerging Infections System (GEIS) Program. The Sponsor was the Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok, Thailand. The main study is registered at ClinicalTrials.gov: study number NCT00722150. NR 17 TC 27 Z9 27 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD DEC 15 PY 2010 VL 51 IS 12 BP E105 EP E114 DI 10.1086/657402 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 681WD UT WOS:000284353100001 PM 21070142 ER PT J AU Walter, TR Subhash, G Sankar, BV Yen, CF AF Walter, T. R. Subhash, G. Sankar, B. V. Yen, C. F. TI Monotonic and cyclic short beam shear response of 3D woven composites SO COMPOSITES SCIENCE AND TECHNOLOGY LA English DT Article DE Textile composites; Delamination; Inter laminar shear strength; Damage tolerance ID INTERLAMINAR SHEAR; FRACTURE-BEHAVIOR; EPOXY COMPOSITES; BALLISTIC IMPACT; TOUGHENED EPOXY; STRENGTH; TOUGHNESS; MATRIX; DAMAGE; TESTS AB Monotonic multi-step and cyclic short beam shear tests were conducted on 20 and 3D woven composites The test results were used to determine the effect of z-yarns on the inter-laminar shear strength as well as the multi loading behavior The presence of z yarns was found to affect not only the inter-laminar shear strength of the composite but also the behavior of the composite beyond the elastic limit Microscopic examination of the damaged specimens revealed large delamination cracks in 2D woven composites while delamination cracks were hindered by z-yarns in 3D composites This crack arrest phenomena resulted in a reduction in inter-laminar crack lengths and a higher distribution of the micro-cracks throughout the 3D composite The multi-step and cyclic loading tests are found to be useful in the monitoring of specimen behavior during short beam shear testing The induced damage was quantified in terms of the loss of strength and stiffness during each loading cycle It was found that while the 2D composites have higher damage resistance the 3D composites have a higher damage tolerance (C) 2010 Elsevier Ltd All rights reserved C1 [Walter, T. R.; Subhash, G.; Sankar, B. V.] Univ Florida, Gainesville, FL 32611 USA. [Yen, C. F.] USA, Res Lab, Survivabil Mat Branch, AMSRD ARL WM MD, Aberdeen Proving Ground, MD 21005 USA. RP Subhash, G (reprint author), Univ Florida, Gainesville, FL 32611 USA. RI Walter, Thomas/K-4857-2015; OI Sankar, Bhavani/0000-0002-4556-1982 FU United States Army Research Office [W911NF-08-1-0120] FX The authors sincerely acknowledge the Program Manager Dr Bruce LaMattina of the United States Army Research Office for providing funding for this work (Grant Number W911NF-08-1-0120) The authors also acknowledge ARL for supplying the composite test panels NR 28 TC 13 Z9 13 U1 1 U2 9 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0266-3538 J9 COMPOS SCI TECHNOL JI Compos. Sci. Technol. PD DEC 15 PY 2010 VL 70 IS 15 BP 2190 EP 2197 DI 10.1016/j.compscitech.2010.08.022 PG 8 WC Materials Science, Composites SC Materials Science GA 683ZQ UT WOS:000284517200008 ER PT J AU Kennedy, AJ Hull, MS Bednar, AJ Goss, JD Gunter, JC Bouldin, JL Vikesland, PJ Steevens, JA AF Kennedy, Alan J. Hull, Matthew S. Bednar, Anthony J. Goss, Jennifer D. Gunter, Jonas C. Bouldin, Jennifer L. Vikesland, Peter J. Steevens, Jeffery A. TI Fractionating Nanosilver: Importance for Determining Toxicity to Aquatic Test Organisms SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Editorial Material ID ACUTE SILVER TOXICITY; NANOPARTICLES; NANOMATERIALS; EXPOSURE; WATER; RISK; FISH AB This investigation applied novel techniques for characterizing and fractionating nanosilver particles and aggregates and relating these measurements to toxicological endpoints. The acute toxicity of eight nanosilver suspensions of varying primary particle sizes (10-80 nm) and coatings (citrate, polyvinylpyrrolidone, EDTA, proprietary) was assessed using three aquatic test organisms (Daphnia magna, Pimephales promelas, Pseudokirchneriella subcapitata). When 48-h lethal median concentrations (LC50) were expressed as total silver, both D. magna and P. promelas were significantly more sensitive to ionic silver (Ag+) as AgNO3 (mean LC50 = 1.2 and 6.3 mu g/L, respectively) relative to a wide range in LC50 values determined for the nanosilver suspensions (2-126 mu g/L). However, when LC50 values for nanosilver suspensions were expressed as fractionated nanosilver (Ag+ and/or <4 nm particles), determined by utiracentrifugation of particles and confirmed field-flow-fractograms, the LC50 values (0.3-5.6 mu g/L) were comparable to the values obtained for ionic Ag+ as AgNO3. These results suggest that dissolved Ag+ plays a critical role in acute toxicity and underscores the importance of characterizing dissolved fractions in nanometal suspensions. C1 [Kennedy, Alan J.] USA, Engineer Res & Dev Ctr, Environm Lab, EP R, Vicksburg, MS 39180 USA. [Hull, Matthew S.; Vikesland, Peter J.] Virginia Polytech Inst & State Univ, Dept Civil & Environm Engn, Blacksburg, VA 24061 USA. [Gunter, Jonas C.] Luna Innovat, Blacksburg, VA USA. [Bouldin, Jennifer L.] Arkansas State Univ, Jonesboro, AR USA. RP Kennedy, AJ (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, EP R, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM alan.J.Kennedy@usace.army.mil RI Hull, Matt/F-4942-2012; Vikesland, Peter/B-3960-2013 OI Vikesland, Peter/0000-0003-2654-5132 NR 28 TC 105 Z9 106 U1 8 U2 75 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD DEC 15 PY 2010 VL 44 IS 24 BP 9571 EP 9577 DI 10.1021/es1025382 PG 7 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 694AK UT WOS:000285266900052 PM 21082828 ER PT J AU Leisher, PO Dong, WM Grimshaw, MP DeFranza, MJ Dubinskii, MA Patterson, SG AF Leisher, Paul O. Dong, Weimin Grimshaw, Mike P. DeFranza, Mark J. Dubinskii, Mark A. Patterson, Steve G. TI Mitigation of Voltage Defect for High-Efficiency InP Diode Lasers Operating at Cryogenic Temperatures SO IEEE PHOTONICS TECHNOLOGY LETTERS LA English DT Article DE Cryogenic; diode lasers; diode-pumped solid-state laser; Er : YAG; eye-safe; high efficiency; high power ID AUGER RECOMBINATION; DEPENDENCE; THRESHOLD AB The power conversion efficiency of cryogenically cooled InP-based diode lasers is limited by excess electrical voltage caused by the freeze-out of holes at low temperature. Hall-effect measurements are performed to determine the ionization energy of Zn in bulk InP and In(0.90)Ga(0.10)As(0.24)P(0.76) (the values obtained are 18.6 and 11.6 meV, respectively). A laser design with an InGaAsP p-cladding layer shows a large decrease in the 77 K voltage defect relative to a more traditional InP design. Peak conversion efficiency of 73% and 10-W maximum power are reported at 1493 nm from a single 200-mu m stripe laser operating at 77 K. C1 [Leisher, Paul O.; Dong, Weimin; Grimshaw, Mike P.; DeFranza, Mark J.; Patterson, Steve G.] nLight Corp, Vancouver, WA 98665 USA. [Dubinskii, Mark A.] USA, Res Lab, Adelphi, MD 20783 USA. RP Leisher, PO (reprint author), nLight Corp, Vancouver, WA 98665 USA. EM pleisher@ieee.org; mdubinskiy@arl.army.mil; spatterson@dilas-inc.com FU United States Army Research Laboratory [W911QX-09-C-0048] FX This work was supported in part by the United States Army Research Laboratory under Contract W911QX-09-C-0048 and has been approved for public release. NR 17 TC 2 Z9 2 U1 1 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1041-1135 J9 IEEE PHOTONIC TECH L JI IEEE Photonics Technol. Lett. PD DEC 15 PY 2010 VL 22 IS 24 BP 1829 EP 1831 DI 10.1109/LPT.2010.2088115 PG 3 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA 691AG UT WOS:000285051700001 ER PT J AU Orr, J Dowd, T Rush, JK Hsu, J Ficke, J Kirk, K AF Orr, Justin Dowd, Thomas Rush, Jeremy K. Hsu, Joseph Ficke, James Kirk, Kevin TI The Effect of Immobilization Devices and Left-Foot Adapter on Brake-Response Time SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Article ID CRUCIATE LIGAMENT RECONSTRUCTION; DRIVING REACTION-TIME; INJURY; REPLACEMENT; LIMB; CAST AB Background: The ability to perform an emergency stop is essential for safe driving and can be represented by total brake-response time, reaction time, and braking time. Immobilization of the lower extremities is routinely performed fora variety of musculoskeletal conditions. This study sought to investigate the effect of immobilization with a left-foot driving adapter, a controlled-ankle-motion device, and a short leg cast on braking times. Our hypothesis was that there would be a significant difference in braking-time values between individuals utilizing a left-foot driving adapter or immobilization device and control individuals wearing normal footwear. Methods: A prospective, observational study was conducted to assess the effect of the immobilization devices on braking times. A driving simulator was used to assess total brake-response time, reaction time, and braking time in thirty-five volunteers. Volunteers were assessed while (1) wearing normal footwear (control group), (2) wearing a controlled-ankle-motion boot, (3) wearing a removable short leg cast, and (4) employing a left-foot driving adapter. Results: The mean total brake-response time was significantly increased as compared with that of the control group in all three study groups. The mean reaction time was significantly increased for the short leg cast and controlled-ankle-motion groups as compared with reaction time in the control group. The mean braking time was significantly increased in the controlled-ankle-motion and left-foot driving-adapter groups as compared with braking time in the control group. Conclusions: Total brake-response time while wearing a controlled-ankle-motion boot or a short leg cast or while utilizing a left-foot driving adapter is significantly increased, or worsened, as compared with the response time while wearing normal footwear. This information may prove valuable to physicians when counseling patients on when it may be safe to return to driving. C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Orr, J (reprint author), William Beaumont Army Med Ctr, 5005 N Piedras St, El Paso, TX 79920 USA. EM tcdowd@gmail.com FU United States Army Institute of Surgical Research FX The authors acknowledge funding from the United States Army Institute of Surgical Research and the support of the Center for the Intrepid for allowing the use of their braking simulator. NR 20 TC 14 Z9 14 U1 1 U2 2 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 USA SN 0021-9355 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD DEC 15 PY 2010 VL 92A IS 18 BP 2871 EP 2877 DI 10.2106/JBJSJ.00225 PG 7 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 704VV UT WOS:000286084600001 PM 21159987 ER PT J AU Tintle, SM Baechler, MF Nanos, GP Forsberg, JA Potter, BK AF Tintle, Scott M. Baechler, Martin F. Nanos, George P., III Forsberg, Jonathan A. Potter, Benjamin K. TI Traumatic and Trauma-Related Amputations Part II: Upper Extremity and Future Directions SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Review ID UPPER-LIMB AMPUTEES; COMPOSITE TISSUE-TRANSPLANTATION; ELECTRICALLY POWERED PROSTHESES; TARGETED MUSCLE REINNERVATION; MANGLED EXTREMITY; MYOELECTRIC PROSTHESIS; INTERNATIONAL REGISTRY; TRANSHUMERAL AMPUTEES; HAND TRANSPLANTATION; SURGICAL TECHNIQUE C1 [Tintle, Scott M.; Baechler, Martin F.; Nanos, George P., III; Forsberg, Jonathan A.; Potter, Benjamin K.] Walter Reed Army Med Ctr, Integrated Dept Orthopaed & Rehabil, Orthopaed Surg Serv, Washington, DC 20307 USA. RP Tintle, SM (reprint author), Walter Reed Army Med Ctr, Integrated Dept Orthopaed & Rehabil, Orthopaed Surg Serv, 6900 Georgia Ave NW,Bldg 2,Clin 5A, Washington, DC 20307 USA. EM Kyle.Potter@amedd.army.mil NR 65 TC 37 Z9 37 U1 1 U2 7 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 USA SN 0021-9355 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD DEC 15 PY 2010 VL 92A IS 18 BP 2934 EP 2945 DI 10.2106/JBJSJ.00258 PG 12 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 704VV UT WOS:000286084600009 PM 21159994 ER PT J AU Lambeth, RH Pederson, SJ Baranoski, M Rawlett, AM AF Lambeth, Robert H. Pederson, Samuel J. Baranoski, Myvan Rawlett, Adam M. TI Methods for Removal of Residual Catalyst from Polymers Prepared by Ring Opening Metathesis Polymerization SO JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY LA English DT Article DE additives; catalysts; purification; ROMP ID RUTHENIUM BY-PRODUCTS; HCV PROTEASE INHIBITOR; OLEFIN METATHESIS; CONVENIENT METHOD; CLOSING METATHESIS; EFFICIENT REMOVAL; PALLADIUM; NANOPARTICLES; 2-NORBORNENE; EXTRACTION AB Methods for removing the residual Grubbs third generation catalyst from polymers prepared by ring opening metathesis polymerization are reported Two strategies were investigated for reduction of the residual catalyst in the final polymer product The first strategy involved the use of heterogeneous functionalized particles to scavenge the catalyst from the solution Filtration of the particles followed by precipitation produced polymers with 10-60 ppm residual catalyst depending on the type of particle used surface functional groups and number of equivalents The second strategy used small organic molecules that could coordinate to the metal species and modify the solubility of the catalyst facilitating partitioning of the catalyst into the precipitation solvent Several types of molecules with varied functionality reduced the residual catalyst level to 30-120 ppm depending on the loading Hydrogenation of the polymer back bone followed by precipitation lowered the residual Ru content from 195 ppm to 10 ppm suggesting that the difficulty of completely removing the catalyst could be a result of coordination of the metal species to the double bonds in the polymer backbone Reducing the amount of trace catalyst significantly improved the oxidative stability of the polymer (c) 2010 Wiley Periodicals Inc J Polym Sci Part A Polym Chem 48 5752-5757 2010 C1 [Lambeth, Robert H.; Pederson, Samuel J.; Baranoski, Myvan; Rawlett, Adam M.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Lambeth, RH (reprint author), USA, Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. FU U S Army Research Laboratory; U S Department of Energy; USARL FX This research was supported in part by an appointment to the Postgraduate Research Participation Program at the U S Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an Interagency agreement between the U S Department of Energy and USARL NR 41 TC 14 Z9 14 U1 4 U2 31 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0887-624X J9 J POLYM SCI POL CHEM JI J. Polym. Sci. Pol. Chem. PD DEC 15 PY 2010 VL 48 IS 24 BP 5752 EP 5757 DI 10.1002/pola.24380 PG 6 WC Polymer Science SC Polymer Science GA 697AT UT WOS:000285485700013 ER PT J AU West, BJ Grigolini, P AF West, B. J. Grigolini, P. TI Habituation and 1/f-noise SO PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS LA English DT Article DE Habituation; 1/f-noise; Renewal statistics; Critical events; Linear response theory ID 1/F NOISE; NEURONAL AVALANCHES; MODEL; NETWORKS; CORTEX AB Habituation is the reversible decrement in the behavior response to a novel and repeating stimulus without a corresponding change in the strength of the stimulus. Dishabituation is a complementary phenomenon in which a habituated process is revitalized by presenting a complex stimulus that is distinct from the original. Herein we propose a statistical habituation model (SHM); a phenomenological model based on a generalization of linear response theory and discrete events. The SHM suggests that the fundamental mechanism producing habituation in its myriad of forms, as well as the associated dishabituation, is the 1/f-noise that is generically produced in complex neuronal networks. Published by Elsevier B.V. C1 [West, B. J.] USA, Res Off, Chair Army ST Corps, Informat Sci Directorate, Durham, NC 27709 USA. [Grigolini, P.] Univ N Texas, Dept Phys, Ctr Nonlinear Sci, Denton, TX 76203 USA. RP West, BJ (reprint author), USA, Res Off, Chair Army ST Corps, Informat Sci Directorate, 4500 S Miami Blvd, Durham, NC 27709 USA. EM Bruce.J.West@us.army.mil FU ARO [W911NF-08-1-0117]; Welch [B-1577] FX P.G. thanks ARO (grant W911NF-08-1-0117) and Welch (grant B-1577) for financial support of this research work. NR 56 TC 8 Z9 8 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-4371 J9 PHYSICA A JI Physica A PD DEC 15 PY 2010 VL 389 IS 24 BP 5706 EP 5718 DI 10.1016/j.physa.2010.08.033 PG 13 WC Physics, Multidisciplinary SC Physics GA 682HQ UT WOS:000284392400020 ER PT J AU Sun, WF Zhang, BG Li, YJ Pritchett, TM Li, ZJ Haley, JE AF Sun, Wenfang Zhang, Bingguang Li, Yunjing Pritchett, Timothy M. Li, Zhongjing Haley, Joy E. TI Broadband Nonlinear Absorbing Platinum 2,2 '-Bipyridine Complex Bearing 2-(Benzothiazol-2 '-yl)-9,9-diethyl-7-ethynylfluorene Ligands SO CHEMISTRY OF MATERIALS LA English DT Article ID EXCITED-STATE ABSORPTION; DIIMINE BIS(ACETYLIDE) COMPLEXES; MOLECULAR PHOTOCHEMICAL DEVICE; ACETYLIDE COMPLEXES; CHARGE-TRANSFER; PHOTOPHYSICS; LUMINESCENCE; PHOTOLUMINESCENCE; DERIVATIVES; BIPYRIDYL AB A platinum 2,2'-bipyridine complex (1) bearing 2-(benzothiazol-2'-yl)-9,9-diethyl-7-ethynylfluorene ligands was synthesized and characterized. Its photophysical properties and nonlinear absorption characteristics were systematically investigated by UV vis absorption, emission, and transient difference absorption spectroscopy, as well as Z-scan and nonlinear transmission techniques. Complex 1 exhibits a strong structureless (1)pi,pi* absorption band at 374 nm and a broad, weak metalto-ligand charge transfer ((MLCT)-M-1) transition in the visible region in CH2Cl2 solution. It emits at approximately 565 nm with vibronic structures at room temperature in polar solvents, attributed to the acetylide ligand (3)pi,pi* excited state. In low-polarity solvents such as hexane and toluene, the emission band becomes structureless and red-shifted, which is assigned to the (MLCT)-M-3 state. The emission spectrum becomes more structured and slightly blue-shifted at 77 K in butyronitrile glassy matrix. In femtosecond and nanosecond transient absorption measurements, 1 exhibits both singlet and triplet excited-state absorption from 450 to 800 nm, which are tentatively attributed to the (1)pi,pi*/(MLCT)-M-1 and (3)pi,pi*/(MLCT)-M-3, respectively. Z scan experiments were carried out using nanosecond and picosecond pulses at 532 nm, and picosecond pulses at a variety of other wavelengths in the visible and near-IR, and the experimental data were fitted by a five-level model using the excited-state lifetimes and estimated cross-section values from the photophysical study. In this way, values were obtained for the first and second singlet excited-state absorption cross sections and the triplet excitedstate absorption cross section throughout the visible and near-IR and for the two-photon absorption (TPA) cross section in the near-IR region. Our results demonstrate that 1 possesses extremely large ratios of the excited-state absorption cross sections to the ground-state absorption in the visible spectral region and, compared to the other two-photon absorbing platinum complexes, the largest two-photon absorption cross sections in the near-IR region. This makes complex 1 a very promising candidate for photonic devices that require large and broadband nonlinear absorption. Reverse saturable absorption of 1 in CH2Cl2 solution at 532 nm for a nanosecond laser pulse was demonstrated. A remarkable transmission decrease was observed when the incident fluence increased. C1 [Sun, Wenfang; Zhang, Bingguang; Li, Yunjing; Li, Zhongjing] N Dakota State Univ, Dept Chem & Biochem, Fargo, ND 58108 USA. [Pritchett, Timothy M.] USA, Res Lab, AMSRD SE EM, Adelphi, MD 20783 USA. [Haley, Joy E.] USAF, Res Lab, Mat & Mfg Directorate, Dayton, OH 45433 USA. [Haley, Joy E.] UES Inc, Dayton, OH 45432 USA. RP Sun, WF (reprint author), N Dakota State Univ, Dept Chem & Biochem, Fargo, ND 58108 USA. EM Wenfang.Sun@ndsu.edu RI li, zhongjing/H-4945-2014 OI li, zhongjing/0000-0002-0125-9693 FU National Science Foundation [CHE-0449598]; Army Research Laboratory [W911NF-06-2-0032] FX This work is supported by National Science Foundation (CAREER Grant CHE-0449598) and the Army Research Laboratory (Grant W911NF-06-2-0032). NR 50 TC 54 Z9 54 U1 2 U2 24 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0897-4756 J9 CHEM MATER JI Chem. Mat. PD DEC 14 PY 2010 VL 22 IS 23 BP 6384 EP 6392 DI 10.1021/cm102494j PG 9 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 690BM UT WOS:000284975100024 ER PT J AU Andersen, NE Karl, JP Cable, SJ Williams, KW Rood, JC Young, AJ Lieberman, HR McClung, JP AF Andersen, Nancy E. Karl, J. Philip Cable, Sonya J. Williams, Kelly W. Rood, Jennifer C. Young, Andrew J. Lieberman, Harris R. McClung, James P. TI Vitamin D status in female military personnel during combat training SO JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION LA English DT Article ID UNITED-STATES; STRESS-FRACTURES; IRON STATUS; WOMEN; SOLDIERS; CALCIUM; ADULTS; MEN AB Vitamin D is an essential nutrient for maintaining bone health. Recent data suggest that vitamin D and calcium supplementation might affect stress fracture incidence in military personnel. Although stress fracture is a health risk for military personnel during training, no study has investigated changes in vitamin D status in Soldiers during United States (US) Army basic combat training (BCT). This longitudinal study aimed to determine the effects of BCT on 25-hydroxyvitamin D (25(OH) D) and parathyroid hormone (PTH) levels in female Soldiers. Serum 25(OH) D and PTH were assessed in 74 fasted Soldier volunteers before and after an 8-week BCT course conducted between August and October in Columbia, South Carolina. In the total study population, 25(OH) D levels decreased (mean +/- SD) from 72.9 +/- 30.0 to 63.3 +/- 19.8 nmol/L (P < 0.05) and PTH levels increased from 36.2 +/- 15.8 to 47.5 +/- 21.2 pg/mL (P < 0.05) during BCT. Ethnicity affected changes in vitamin D status (ethnicity-by-time interaction, P < 0.05); 25(OH) D decreased (P < 0.05) in both Hispanic and non-Hispanic whites, but did not change in non-Hispanic blacks. Ethnicity did not affect BCT-induced changes in PTH. These data indicate that vitamin D status in female Soldiers may decline during military training in the late summer and early autumn months in the Southeastern US. Future studies should strive to determine the impact of military clothing and seasonality on vitamin D status, as well as the functional impact of declining vitamin D status on bone health. C1 [Andersen, Nancy E.; Karl, J. Philip; Young, Andrew J.; Lieberman, Harris R.; McClung, James P.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [Cable, Sonya J.; Williams, Kelly W.] Directorate Basic Combat Training, Ft Jackson, SC 29207 USA. [Rood, Jennifer C.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA. RP McClung, JP (reprint author), USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. EM james.mcclung3@us.army.mil RI McClung, James/A-1989-2009; OI Karl, J. Philip/0000-0002-5871-2241 FU US Army Medical Research and Materiel Command FX This work was supported by the US Army Medical Research and Materiel Command. The authors wish to acknowledge the Soldier volunteers that participated in this study as well as the command staff at Fort Jackson, SC, for allowing access to Soldiers. Portions of this manuscript were presented in abstract form at Experimental Biology 2010, Anaheim, CA, April 24-28. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Army or the Department of Defense. Any citations of commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement of approval of the products or services of these organizations. NR 20 TC 10 Z9 10 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1550-2783 J9 J INT SOC SPORT NUTR JI J. Int. Soc. Sport Nutr. PD DEC 14 PY 2010 VL 7 AR 38 DI 10.1186/1550-2783-7-38 PG 5 WC Nutrition & Dietetics; Sport Sciences SC Nutrition & Dietetics; Sport Sciences GA 702ZA UT WOS:000285933200001 PM 21156069 ER PT J AU Wang, M Yu, JH Hsieh, AJ Rutledge, GC AF Wang, M. Yu, J. H. Hsieh, A. J. Rutledge, G. C. TI Effect of tethering chemistry of cationic surfactants on clay exfoliation, electrospinning and diameter of PMMA/clay nanocomposite fibers SO POLYMER LA English DT Article DE Electrospinning; Nanofiber; Clay nanocomposite ID LAYERED SILICATE NANOCOMPOSITES; ELECTRICALLY FORCED JETS; POLY(METHYL METHACRYLATE); EMULSION POLYMERIZATION; MECHANICAL-PROPERTIES; COMPOSITE NANOFIBERS; POLY(ETHYLENE OXIDE); MOLECULAR-WEIGHT; GOOD SOLVENT; RHEOLOGY AB We examine the influence of tethering chemistry of cationic surfactants on exfoliation of montmorillonite (MMT) clay dispersed in methyl methacrylate (MMA) followed by in-situ polymerization to form poly(methyl methacrylate) (PMMA) nanocomposites, the effect of exfoliation and clay loading on the rheology of polymer/clay dispersions in dimethyl formamide, and the diameters of nanocomposite fibers formed from these dispersions by electrospinning. Incorporation of an additional reactive tethering group of methacryl functionality significantly improves the intercalation and exfoliation of clays in both in-situ polymerized PMMA nanocomposites and the corresponding electrospun fibers. The proper surfactant chemistry also increases the dispersion stability, extensional viscosity, extent of strain hardening and thus the electrospinnablity of the nanocomposite dispersions, especially at low nanocomposite concentrations. The degree of the enhancement in electrospinnability by clays with proper tethering chemistry is at least the same as or greater than that obtained with three times higher loading level of clay particles without proper tethering chemistry in the nanocomposites. These results suggest a new strategy to produce smaller diameter fibers from very dilute polymer solutions, which are otherwise not electrospinnable, by incorporating a small amount of well-exfoliated clays. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Wang, M.; Yu, J. H.; Rutledge, G. C.] MIT, Dept Chem Engn, Cambridge, MA 02139 USA. [Wang, M.; Yu, J. H.; Rutledge, G. C.] MIT, Inst Soldier Nanotechnol, Cambridge, MA 02139 USA. [Hsieh, A. J.] USA, Res Lab, RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA. RP Rutledge, GC (reprint author), MIT, Dept Chem Engn, Cambridge, MA 02139 USA. EM rutledge@mit.edu FU U.S. Army through the Institute for Soldier Nanotechnologies [DAAD-19-02-D0002]; U.S. Army Research Office [DAAD-19-02-D0002] FX A.J.H. thanks Triton Systems, Inc. for the PMMA nanocomposites which were synthesized and prepared under an Army Research Laboratory SBIR program, DAAD17-00-C-0091. Useful discussions with S.V. Fridrikh on extensional rheology and electrospinnability are gratefully acknowledged. This research was supported by the U.S. Army through the Institute for Soldier Nanotechnologies, under Contract DAAD-19-02-D0002 with the U.S. Army Research Office. NR 65 TC 10 Z9 10 U1 2 U2 54 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 EI 1873-2291 J9 POLYMER JI Polymer PD DEC 10 PY 2010 VL 51 IS 26 BP 6295 EP 6302 DI 10.1016/j.polymer.2010.10.040 PG 8 WC Polymer Science SC Polymer Science GA 693OH UT WOS:000285232900025 ER PT J AU Pereyra, FP Jia, XM McLaren, PJ Telenti, A de Bakker, PIW Walker, BD Ripke, S Brumme, CJ Pulit, SL Carrington, M Kadie, CM Carlson, JM Heckerman, D Graham, RR Plenge, RM Deeks, SG Gianniny, L Crawford, G Sullivan, J Gonzalez, E Davies, L Camargo, A Moore, JM Beattie, N Gupta, S Crenshaw, A Burtt, NP Guiducci, C Gupta, N Carrington, M Gao, XJ Qi, Y Yuki, Y Piechocka-Trocha, A Cutrell, E Rosenberg, R Moss, KL Lemay, P O'Leary, J Schaefer, T Verma, P Toth, I Block, B Baker, B Rothchild, A Lian, J Proudfoot, J Alvino, DML Vine, S Addo, MM Allen, TM Altfeld, M Henn, MR Le Gall, S Streeck, H Haas, DW Kuritzkes, DR Robbins, GK Shafer, RW Gulick, RM Shikuma, CM Haubrich, R Riddler, S Sax, PE Daar, ES Ribaudo, HJ Agan, B Agarwal, S Ahern, RL Allen, BL Altidor, S Altschuler, EL Ambardar, S Anastos, K Anderson, B Anderson, V Andrady, U Antoniskis, D Bangsberg, D Barbaro, D Barrie, W Bartczak, J Barton, S Basden, P Basgoz, N Bazner, S Bellos, NC Benson, AM Berger, J Bernard, NF Bernard, AM Birch, C Bodner, SJ Bolan, RK Boudreaux, ET Bradley, M Braun, JF Brndjar, JE Brown, SJ Brown, K Brown, ST Burack, J Bush, LM Cafaro, V Campbell, O Campbell, J Carlson, RH Carmichael, JK Casey, KK Cavacuiti, C Celestin, G Chambers, ST Chez, N Chirch, LM Cimoch, PJ Cohen, D Cohn, LE Conway, B Cooper, DA Cornelson, B Cox, DT Cristofano, MV Cuchural, G Czartoski, JL Dahman, JM Daly, JS Davis, BT Davis, K Davod, SM Deeks, SG DeJesus, E Dietz, CA Dunham, E Dunn, ME Ellerin, TB Eron, JJ Fangman, JJW Farel, CE Ferlazzo, H Fidler, S Fleenor-Ford, A Frankel, R Freedberg, KA French, NK Fuchs, JD Fuller, JD Gaberman, J Gallant, JE Gandhi, RT Garcia, E Garmon, D Gathe, JC Gaultier, CR Gebre, W Gilman, FD Gilson, I Goepfert, PA Gottlieb, MS Goulston, C Groger, RK Gurley, TD Haber, S Hardwicke, R Hardy, WD Harrigan, PR Hawkins, TN Heath, S Hecht, FM Henry, WK Hladek, M Hoffman, RP Horton, JM Hsu, RK Huhn, GD Hunt, P Hupert, MJ Illeman, ML Jaeger, H Jellinger, RM John, M Johnson, JA Johnson, KL Johnson, H Johnson, K Joly, J Jordan, WC Kauffman, CA Khanlou, H Killian, RK Kim, AY Kim, DD Kinder, CA Kirchner, JT Kogelman, L Kojic, EM Korthuis, T Kurisu, W Kwon, DS LaMar, M Lampiris, H Lanzafame, M Lederman, MM Lee, DM Lee, JML Lee, MJ Lee, ETY Lemoine, J Levy, JA Llibre, JM Liguori, MA Little, SJ Liu, AY Lopez, AJ Loutfy, MR Loy, D Mohammed, DY Man, A Mansour, MK Marconi, VC Markowitz, M Marques, R Martin, JN Martin, HL Mayer, KH McElrath, MJ McGhee, TA McGovern, BH McGowan, K McIntyre, D Mcleod, GX Menezes, P Mesa, G Metroka, CE Meyer-Olson, D Miller, AO Montgomery, K Mounzer, KC Nagami, EH Nagin, I Nahass, RG Nelson, MO Nielsen, C Norene, DL O'Connor, DH Ojikutu, BO Okulicz, J Oladehin, OO Oldfield, EC Olender, SA Ostrowski, M Owen, WF Pae, E Parsonnet, J Pavlatos, AM Perlmutter, AM Pierce, MN Pincus, JM Pisani, L Price, LJ Proia, L Prokesch, RC Pujet, HC Ramgopal, M Rathod, A Rausch, M Ravishankar, J Rhame, FS Richards, CS Richman, DD Robbins, GK Rodes, B Rodriguez, M Rose, RC Rosenberg, ES Rosenthal, D Ross, PE Rubin, DS Rumbaugh, E Saenz, L Salvaggio, MR Sanchez, WC Sanjana, VM Santiago, S Schmidt, W Schuitemaker, H Sestak, PM Shalit, P Shay, W Shirvani, VN Silebi, VI Sizemore, JM Skolnik, PR Sokol-Anderson, M Sosman, JM Stabile, P Stapleton, JT Starrett, S Stein, F Stellbrink, HJ Sterman, FL Stone, VE Stone, DR Tambussi, G Taplitz, RA Tedaldi, EM Telenti, A Theisen, W Torres, R Tosiello, L Tremblay, C Tribble, MA Trinh, PD Tsao, A Ueda, P Vaccaro, A Valadas, E Vanig, TJ Vecino, I Vega, VM Veikley, W Wade, BH Walworth, C Wanidworanun, C Ward, DJ Warner, DA Weber, RD Webster, D Weis, S Wheeler, DA White, DJ Wilkins, E Winston, A Wlodaver, CG van't Wout, A Wright, DP Yang, OO Yurdin, DL Zabukovic, BW Zachary, KC Zeeman, B Zhao, M AF Pereyra, Florencia Jia, Xiaoming McLaren, Paul J. Telenti, Amalio de Bakker, Paul I. W. Walker, Bruce D. Ripke, Stephan Brumme, Chanson J. Pulit, Sara L. Carrington, Mary Kadie, Carl M. Carlson, Jonathan M. Heckerman, David Graham, Robert R. Plenge, Robert M. Deeks, Steven G. Gianniny, Lauren Crawford, Gabriel Sullivan, Jordan Gonzalez, Elena Davies, Leela Camargo, Amy Moore, Jamie M. Beattie, Nicole Gupta, Supriya Crenshaw, Andrew Burtt, Noel P. Guiducci, Candace Gupta, Namrata Carrington, Mary Gao, Xiaojiang Qi, Ying Yuki, Yuko Piechocka-Trocha, Alicja Cutrell, Emily Rosenberg, Rachel Moss, Kristin L. Lemay, Paul O'Leary, Jessica Schaefer, Todd Verma, Pranshu Toth, Ildiko Block, Brian Baker, Brett Rothchild, Alissa Lian, Jeffrey Proudfoot, Jacqueline Alvino, Donna Marie L. Vine, Seanna Addo, Marylyn M. Allen, Todd M. Altfeld, Marcus Henn, Matthew R. Le Gall, Sylvie Streeck, Hendrik Haas, David W. Kuritzkes, Daniel R. Robbins, Gregory K. Shafer, Robert W. Gulick, Roy M. Shikuma, Cecilia M. Haubrich, Richard Riddler, Sharon Sax, Paul E. Daar, Eric S. Ribaudo, Heather J. Agan, Brian Agarwal, Shanu Ahern, Richard L. Allen, Brady L. Altidor, Sherly Altschuler, Eric L. Ambardar, Sujata Anastos, Kathryn Anderson, Ben Anderson, Val Andrady, Ushan Antoniskis, Diana Bangsberg, David Barbaro, Daniel Barrie, William Bartczak, J. Barton, Simon Basden, Patricia Basgoz, Nesli Bazner, Suzane Bellos, Nicholaos C. Benson, Anne M. Berger, Judith Bernard, Nicole F. Bernard, Annette M. Birch, Christopher Bodner, Stanley J. Bolan, Robert K. Boudreaux, Emilie T. Bradley, Meg Braun, James F. Brndjar, Jon E. Brown, Stephen J. Brown, Katherine Brown, Sheldon T. Burack, Jedidiah Bush, Larry M. Cafaro, Virginia Campbell, Omobolaji Campbell, John Carlson, Robert H. Carmichael, J. Kevin Casey, Kathleen K. Cavacuiti, Chris Celestin, Gregory Chambers, Steven T. Chez, Nancy Chirch, Lisa M. Cimoch, Paul J. Cohen, Daniel Cohn, Lillian E. Conway, Brian Cooper, David A. Cornelson, Brian Cox, David T. Cristofano, Michael V. Cuchural, George, Jr. Czartoski, Julie L. Dahman, Joseph M. Daly, Jennifer S. Davis, Benjamin T. Davis, Kristine Davod, Sheila M. Deeks, Steven G. DeJesus, Edwin Dietz, Craig A. Dunham, Eleanor Dunn, Michael E. Ellerin, Todd B. Eron, Joseph J. Fangman, John J. W. Farel, Claire E. Ferlazzo, Helen Fidler, Sarah Fleenor-Ford, Anita Frankel, Renee Freedberg, Kenneth A. French, Neel K. Fuchs, Jonathan D. Fuller, Jon D. Gaberman, Jonna Gallant, Joel E. Gandhi, Rajesh T. Garcia, Efrain Garmon, Donald Gathe, Joseph C., Jr. Gaultier, Cyril R. Gebre, Wondwoosen Gilman, Frank D. Gilson, Ian Goepfert, Paul A. Gottlieb, Michael S. Goulston, Claudia Groger, Richard K. Gurley, T. Douglas Haber, Stuart Hardwicke, Robin Hardy, W. David Harrigan, P. Richard Hawkins, Trevor N. Heath, Sonya Hecht, Frederick M. Henry, W. Keith Hladek, Melissa Hoffman, Robert P. Horton, James M. Hsu, Ricky K. Huhn, Gregory D. Hunt, Peter Hupert, Mark J. Illeman, Mark L. Jaeger, Hans Jellinger, Robert M. John, Mina Johnson, Jennifer A. Johnson, Kristin L. Johnson, Heather Johnson, Kay Joly, Jennifer Jordan, Wilbert C. Kauffman, Carol A. Khanlou, Homayoon Killian, Robert K. Kim, Arthur Y. Kim, David D. Kinder, Clifford A. Kirchner, Jeffrey T. Kogelman, Laura Kojic, Erna Milunka Korthuis, Todd Kurisu, Wayne Kwon, Douglas S. LaMar, Melissa Lampiris, Harry Lanzafame, Massimiliano Lederman, Michael M. Lee, David M. Lee, Jean M. L. Lee, Marah J. Lee, Edward T. Y. Lemoine, Janice Levy, Jay A. Llibre, Josep M. Liguori, Michael A. Little, Susan J. Liu, Anne Y. Lopez, Alvaro J. Loutfy, Mono R. Loy, Dawn Mohammed, Debbie Y. Man, Alan Mansour, Michael K. Marconi, Vincent C. Markowitz, Martin Marques, Rui Martin, Jeffrey N. Martin, Harold L., Jr. Mayer, Kenneth Hugh McElrath, M. Juliana McGhee, Theresa A. McGovern, Barbara H. McGowan, Katherine McIntyre, Dawn Mcleod, Gavin X. Menezes, Prema Mesa, Greg Metroka, Craig E. Meyer-Olson, Dirk Miller, Andy O. Montgomery, Kate Mounzer, Karam C. Nagami, Ellen H. Nagin, Iris Nahass, Ronald G. Nelson, Margret O. Nielsen, Craig Norene, David L. O'Connor, David H. Ojikutu, Bisola O. Okulicz, Jason Oladehin, Olakunle O. Oldfield, Edward C., III Olender, Susan A. Ostrowski, Mario Owen, William F., Jr. Pae, Eunice Parsonnet, Jeffrey Pavlatos, Andrew M. Perlmutter, Aaron M. Pierce, Michael N. Pincus, Jonathan M. Pisani, Leandro Price, Lawrence Jay Proia, Laurie Prokesch, Richard C. Pujet, Heather Calderon Ramgopal, Moti Rathod, Almas Rausch, Michael Ravishankar, J. Rhame, Frank S. Richards, Constance Shamuyarira Richman, Douglas D. Robbins, Gregory K. Rodes, Berta Rodriguez, Milagros Rose, Richard C., III Rosenberg, Eric S. Rosenthal, Daniel Ross, Polly E. Rubin, David S. Rumbaugh, Elease Saenz, Luis Salvaggio, Michelle R. Sanchez, William C. Sanjana, Veeraf M. Santiago, Steven Schmidt, Wolfgang Schuitemaker, Hanneke Sestak, Philip M. Shalit, Peter Shay, William Shirvani, Vivian N. Silebi, Vanessa I. Sizemore, James M., Jr. Skolnik, Paul R. Sokol-Anderson, Marcia Sosman, James M. Stabile, Paul Stapleton, Jack T. Starrett, Sheree Stein, Francine Stellbrink, Hans-Jurgen Sterman, F. Lisa Stone, Valerie E. Stone, David R. Tambussi, Giuseppe Taplitz, Randy A. Tedaldi, Ellen M. Telenti, Amalio Theisen, William Torres, Richard Tosiello, Lorraine Tremblay, Cecile Tribble, Marc A. Trinh, Phuong D. Tsao, Alice Ueda, Peggy Vaccaro, Anthony Valadas, Emilia Vanig, Thanes J. Vecino, Isabel Vega, Vilma M. Veikley, Wenoah Wade, Barbara H. Walworth, Charles Wanidworanun, Chingchai Ward, Douglas J. Warner, Daniel A. Weber, Robert D. Webster, Duncan Weis, Steve Wheeler, David A. White, David J. Wilkins, Ed Winston, Alan Wlodaver, Clifford G. van't Wout, Angelique Wright, David P. Yang, Otto O. Yurdin, David L. Zabukovic, Brandon W. Zachary, Kimon C. Zeeman, Beth Zhao, Meng CA Int HIV Controllers Study TI The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation SO SCIENCE LA English DT Article ID DISEASE PROGRESSION; SURFACE EXPRESSION; INFECTION; AIDS; ALLELES; MHC; RESTRICTION; ASSOCIATION; THERAPY; ABSENCE AB Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the major histocompatibility complex (MHC); however, the basis for these associations remains elusive. To define host genetic effects on the outcome of a chronic viral infection, we performed genome-wide association analysis in a multiethnic cohort of HIV-1 controllers and progressors, and we analyzed the effects of individual amino acids within the classical human leukocyte antigen (HLA) proteins. We identified >300 genome-wide significant single-nucleotide polymorphisms (SNPs) within the MHC and none elsewhere. Specific amino acids in the HLA-B peptide binding groove, as well as an independent HLA-C effect, explain the SNP associations and reconcile both protective and risk HLA alleles. These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection. C1 [Pereyra, Florencia; Walker, Bruce D.; Brumme, Chanson J.; Carrington, Mary; Piechocka-Trocha, Alicja; Cutrell, Emily; Rosenberg, Rachel; Moss, Kristin L.; Lemay, Paul; O'Leary, Jessica; Schaefer, Todd; Verma, Pranshu; Toth, Ildiko; Block, Brian; Baker, Brett; Rothchild, Alissa; Lian, Jeffrey; Proudfoot, Jacqueline; Alvino, Donna Marie L.; Vine, Seanna; Addo, Marylyn M.; Allen, Todd M.; Altfeld, Marcus; Le Gall, Sylvie; Streeck, Hendrik; Bazner, Suzane; Birch, Christopher; Bradley, Meg; Kwon, Douglas S.; Nagami, Ellen H.; Pae, Eunice; Rathod, Almas; Tsao, Alice; Ueda, Peggy; Zeeman, Beth] Massachusetts Inst Technol & Harvard, Massachusetts Gen Hosp, Regon Inst, Boston, MA USA. [Pereyra, Florencia; Kuritzkes, Daniel R.; Sax, Paul E.; Farel, Claire E.; Johnson, Jennifer A.; Liu, Anne Y.; McGowan, Katherine; Theisen, William] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Div Infect Dis, Boston, MA 02115 USA. [Jia, Xiaoming] Harvard Mit Div Hlth Sci & Technol, Boston, MA USA. [McLaren, Paul J.; de Bakker, Paul I. W.; Ripke, Stephan; Pulit, Sara L.; Plenge, Robert M.; Gianniny, Lauren; Crawford, Gabriel; Sullivan, Jordan; Gonzalez, Elena; Davies, Leela; Camargo, Amy; Moore, Jamie M.; Beattie, Nicole; Gupta, Supriya; Crenshaw, Andrew; Burtt, Noel P.; Guiducci, Candace; Gupta, Namrata; Henn, Matthew R.] Harvard & MIT, Broad Inst, Cambridge, MA USA. [McLaren, Paul J.; de Bakker, Paul I. W.; Pulit, Sara L.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Div Genet, Boston, MA 02115 USA. [Telenti, Amalio] Univ Lausanne, Inst Microbiol, Lausanne, Switzerland. [de Bakker, Paul I. W.] Univ Med Ctr Utrecht, Dept Med Genet, Div Biomed Genet, Utrecht, Netherlands. [de Bakker, Paul I. W.] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands. [Walker, Bruce D.] Howard Hughes Med Inst, Chevy Chase, MD USA. [Ripke, Stephan] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Human Genet Res,Dept Med, Boston, MA USA. [Gao, Xiaojiang; Qi, Ying; Yuki, Yuko] NCI, Canc & Inflammat Program, Expt Immunol Lab, SAIC Frederick, Frederick, MD 21701 USA. [Kadie, Carl M.] Microsoft Res, Redmond, WA USA. [Carlson, Jonathan M.; Heckerman, David] Microsoft Res, Los Angeles, CA USA. [Graham, Robert R.] Genentech Inc, San Francisco, CA 94080 USA. [Plenge, Robert M.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Div Rheumatol Immunol & Allergy, Boston, MA 02115 USA. [Deeks, Steven G.; Hecht, Frederick M.; Hunt, Peter; Lampiris, Harry; Levy, Jay A.; Martin, Jeffrey N.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Haas, David W.] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA. [Shafer, Robert W.] Stanford Univ, Palo Alto, CA 94304 USA. [Gulick, Roy M.] Cornell Univ, Weill Med Coll, New York, NY 10021 USA. [Shikuma, Cecilia M.] Univ Hawaii, John A Burns Sch Med, Hawaii Ctr AIDS, Honolulu, HI 96822 USA. [Haubrich, Richard; Little, Susan J.; Richman, Douglas D.; Taplitz, Randy A.] Univ Calif San Diego, San Diego, CA 92103 USA. [Riddler, Sharon] Univ Pittsburgh, Pittsburgh, PA USA. [Daar, Eric S.; Hardy, W. David; Yang, Otto O.] Univ Calif Los Angeles, Los Angeles, CA USA. [Ribaudo, Heather J.] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. [Agan, Brian] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Agarwal, Shanu] Summa Hlth Syst, Akron, OH USA. [Allen, Brady L.; Lee, David M.] Uptown Phys Grp, Dallas, TX USA. [Altidor, Sherly; Metroka, Craig E.] St Lukes Roosevelt Hosp, New York, NY 10025 USA. [Altschuler, Eric L.; Mohammed, Debbie Y.] Univ Med & Dent New Jersey, New Jersey Med Sch, Univ Hosp, Newark, NJ 07103 USA. [Anastos, Kathryn] Montefiore Med Ctr, Albert Einstein Coll Med, Bronx, NY 10467 USA. [Anderson, Ben] St Leonards Med Ctr, St Leonards, NSW, Australia. [Anderson, Val; Andrady, Ushan] Ysbyty Gwynedd Hosp, Bangor, Gwynedd, Wales. [Antoniskis, Diana; Man, Alan; Rumbaugh, Elease] Kaiser Permanente, Portland, OR USA. [Barbaro, Daniel; Hupert, Mark J.; Johnson, Heather] Tarrant Cty Infect Dis Associates, Ft Worth, TX USA. [Bartczak, J.] Rowan Tree Med, Wilton Manors, FL USA. [Barton, Simon] Chelsea & Westminster Hosp, St Stephens Ctr, London, England. [Bellos, Nicholaos C.] SW Infect Dis Associates, Dallas, TX USA. [Berger, Judith] St Barnabas Hosp, Bronx, NY USA. [Bernard, Nicole F.] McGill Univ, Montreal Gen Hosp, Ctr Hlth, Res Inst, Montreal, PQ H3G 1A4, Canada. [Bernard, Annette M.] Thacker Thompson & Bernard, Atlanta, GA USA. [Bodner, Stanley J.] Vanderbilt Univ, Sch ofMedicine, Hermitage, TN USA. [Bolan, Robert K.] LA Gay & Lesbian Ctr, Los Angeles, CA USA. [Boudreaux, Emilie T.] Louisiana State Univ, Hlth Sci Ctr, Univ Med Ctr E Clin, Lafayatte, LA USA. [Braun, James F.] Callen Lorde Community Hlth Ctr, Phys Res Network, New York, NY USA. [Brndjar, Jon E.] Brndjar Med Associates, Allentown, PA USA. [Brown, Stephen J.] AIDS Res Alliance, Los Angeles, CA USA. [Brown, Katherine] David Powell Community Hlth Ctr, Austin, TX USA. [Brown, Sheldon T.] James J Peters VA Med Ctr, Bronx, NY USA. [Burack, Jedidiah] Sunrise Med Grp, Brooklyn, NY USA. [Bush, Larry M.] Univ Miami, Miller Sch Med, Lake Worth, FL USA. [Cafaro, Virginia] WellSpring Med Grp, San Francisco, CA USA. [Campbell, John] Moses Cone Hlth Syst, Greensboro, NC USA. [Carlson, Robert H.] HealthPartners Infect Dis, St Paul, MN USA. [Carmichael, J. Kevin] El Rio Special Immunol Associates, Tucson, AZ USA. [Casey, Kathleen K.; McIntyre, Dawn] Jersey Shore Univ, Med Ctr, Neptune, NJ USA. [Cavacuiti, Chris; Cornelson, Brian] St Michaels Hosp, Toronto, ON M5B 1W8, Canada. [Celestin, Gregory] PATH Ctr, Brooklyn Hosp Ctr, Brooklyn, NY USA. [Chambers, Steven T.] Univ Otago, Christchurch, New Zealand. [Chez, Nancy] HELP Project Samaritan, Bronx, NY USA. [Chirch, Lisa M.; Dunham, Eleanor; Joly, Jennifer] David E Rogers Ctr HIV AIDS Care, Southampton, NY USA. [Cimoch, Paul J.; Walworth, Charles] Ctr Special Immunol, Fountain Valley, CA USA. [Cohen, Daniel; Mayer, Kenneth Hugh] Fenway Community Hlth, Boston, MA USA. [Cohn, Lillian E.] 9th St Internal Med Associates, Philadelphia, PA USA. [Conway, Brian] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada. [Cooper, David A.] Natl Ctr HIV Epidemiol & Clin Res, Sydney, NSW, Australia. [Cox, David T.] Metro Infect Dis Consultants, Indianapolis, IN USA. [Cristofano, Michael V.] John H Stroger Hosp Cook Cty, Chicago, IL USA. [Cuchural, George, Jr.] New England Qual Care Alliance, Braintree, MA USA. [Czartoski, Julie L.; Lee, Jean M. L.; McElrath, M. Juliana] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Dahman, Joseph M.] Desert AIDS Project, Palm Springs, CA USA. [Daly, Jennifer S.] Univ Massachusetts, Mem Med Ctr, Worcester, MA 01605 USA. [Davis, Kristine] Univ Iowa Hosp & Clin, Iowa City, IA 52242 USA. [DeJesus, Edwin] Orlando Immunol Ctr, Orlando, FL USA. [Dietz, Craig A.] Kansas City Free Hlth Clin, Kansas City, MO USA. [Ellerin, Todd B.] S Shore Hosp, Weymouth, MA USA. [Eron, Joseph J.; Menezes, Prema] Univ N Carolina, Chapel Hill, NC USA. [Fangman, John J. W.] AIDS Resource Ctr Wisconsin, Milwaukee, WI USA. [Ferlazzo, Helen; Stein, Francine] Visiting Nurse Assoc Cent New Jersey, Ctr Community Hlth, Asbury Pk, NJ USA. [Fidler, Sarah; Winston, Alan] Univ London Imperial Coll Sci Technol & Med, London, England. [Fleenor-Ford, Anita] Heartland Clin, Paducah, KY USA. [Frankel, Renee] Morristown Mem Hosp, Morristown, NJ USA. [Fuchs, Jonathan D.] San Francisco Dept Publ Hlth, San Francisco, CA USA. [Fuller, Jon D.; Skolnik, Paul R.] Boston Univ, Med Ctr, Boston, MA USA. [Gaberman, Jonna] Baystate Med Ctr, Springfield, MA USA. [Gallant, Joel E.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Gaultier, Cyril R.] Tower Infect Dis, Los Angeles, CA USA. [Gebre, Wondwoosen] Nassau Univ Med Ctr, E Meadow, NY USA. [Gilman, Frank D.; Kurisu, Wayne] Sharp Rees Stealy Med Ctr, San Diego, CA USA. [Gilson, Ian] Med Coll Wisconsin, Milwaukee, WI 53226 USA. [Goepfert, Paul A.; Heath, Sonya] Univ Alabama, Birmingham, AL USA. [Gottlieb, Michael S.] Synergy Hematol & Oncol, Los Angeles, CA USA. [Goulston, Claudia] Univ Utah, Salt Lake City, UT USA. [Groger, Richard K.] S Dayton Acute Care Consultants, Dayton, OH USA. [Haber, Stuart; Shay, William] St Vincents Hosp, New York, NY USA. [Hardwicke, Robin] Univ Texas Hlth Sci Ctr, Houston, TX USA. [Harrigan, P. Richard] British Columbia Ctr Excellence HIV AIDS, Vancouver, BC, Canada. [Hawkins, Trevor N.; Veikley, Wenoah] SW CARE Ctr, Santa Fe, NM USA. [Henry, W. Keith] Hennepin Cty Med Ctr, Minneapolis, MN 55415 USA. 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[Markowitz, Martin] Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10021 USA. [Martin, Harold L., Jr.] Pk Nicollet Clin, St Louis, MN USA. [McGhee, Theresa A.] Absolute Care, Atlanta, GA USA. [Mcleod, Gavin X.] Columbia Univ, Coll Phys & Surg, New York, NY USA. [Mesa, Greg] Highland Med Associates, Hendersonville, NC USA. [Meyer-Olson, Dirk] Hannover Med Sch, Abt Klin Immunol, D-30623 Hannover, Germany. [Miller, Andy O.] Hosp Special Surg, New York, NY 10021 USA. [Mounzer, Karam C.] Philadelphia FIGHT, Philadelphia, PA USA. [Nagin, Iris] Lower E Side Serv Ctr, New York, NY USA. [Nielsen, Craig] Univ Colorado, Aurora, CO USA. [Norene, David L.] Sutter Med Grp, Sacramento, CA USA. [O'Connor, David H.; Sosman, James M.] Univ Wisconsin, Madison, WI USA. [Okulicz, Jason] Brooke Army Med Ctr, San Antonio, TX USA. [Oldfield, Edward C., III] Eastern Virginia Med Sch, Norfolk, VA 23501 USA. [Olender, Susan A.] Columbia Univ, Med Ctr, New York, NY USA. [Owen, William F., Jr.] CA Pacific Med Ctr, San Francisco, CA USA. [Parsonnet, Jeffrey] Dartmouth Hitchcock Med Ctr, Lebanon, NH 03766 USA. [Pavlatos, Andrew M.] St Joseph Hosp, Chicago, IL USA. [Pincus, Jonathan M.] Codman Sq Hlth Ctr, Dorchester, MA USA. [Pisani, Leandro; Rodriguez, Milagros; Saenz, Luis; Santiago, Steven] CARE Resource, Miami, FL USA. [Price, Lawrence Jay] Castro Mission Hlth Ctr, San Francisco, CA USA. [Proia, Laurie] Rush Med Coll, Chicago, IL 60612 USA. [Pujet, Heather Calderon] Boulder Community Hosp, Boulder, CO USA. [Ramgopal, Moti] Midway Immunol & Res Ctr, Ft Pierce, FL USA. [Rausch, Michael] Aerztezentrum Nollendorfpl, Berlin, Germany. [Ravishankar, J.] Suny Downstate Med Ctr, Brooklyn, NY 11203 USA. [Rhame, Frank S.] Clin 42, Minneapolis, MN USA. [Richards, Constance Shamuyarira] King Edward Mem Hosp, Paget, Bermuda. [Rodes, Berta] Hosp Carlos III, Fdn Invest Biomed, Madrid, Spain. [Rose, Richard C., III] Summit Med Grp, Knoxville, TN USA. [Rosenthal, Daniel] Med Consultants S Florida, Coral Springs, FL USA. [Ross, Polly E.] Western N Carolina Community Hlth Serv, Asheville, NC USA. [Rubin, David S.] New York Hosp, Queens Med Ctr, Flushing, NY USA. [Salvaggio, Michelle R.] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA. [Sanchez, William C.] Georgetown Univ, Med Ctr, Washington, DC 20007 USA. [Sanjana, Veeraf M.] Village Care Hlth Ctr, New York, NY USA. [Schuitemaker, Hanneke; van't Wout, Angelique] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands. [Sestak, Philip M.] St Pauls Hosp, Vancouver, BC V6Z 1Y6, Canada. [Shalit, Peter] Swedish Med Ctr, Seattle, WA USA. [Shirvani, Vivian N.] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA. [Silebi, Vanessa I.] Mercy Hosp, Miami, FL USA. [Sizemore, James M., Jr.] Univ Tennessee, Chattanooga, TN USA. [Sokol-Anderson, Marcia] St Louis Univ, St Louis, MO 63103 USA. [Stabile, Paul] William F Ryan Community Hlth Ctr, New York, NY USA. [Stapleton, Jack T.] Univ Iowa, Iowa City, IA USA. [Starrett, Sheree] Rivington House & Village Care, New York, NY USA. [Stellbrink, Hans-Jurgen] Infekt Med Ctr Hamburg, Hamburg, Germany. [Sterman, F. Lisa] Calif Pacific Med Ctr, San Francisco, CA USA. [Stone, David R.] Lemuel Shattuck Hosp, Boston, MA USA. [Tambussi, Giuseppe] Fdn San Raffaele Del Monte Tabor, Milan, Italy. [Tedaldi, Ellen M.] Temple Univ, Sch Med, Philadelphia, PA 19122 USA. [Torres, Richard] Yale Univ, Sch Med, Bridgeport, CT USA. [Tosiello, Lorraine] Jersey City Med Ctr, Jersey City, NJ USA. [Tremblay, Cecile] Univ Montreal, Montreal, PQ, Canada. [Tribble, Marc A.] Baylor Univ, Med Ctr, Dallas, TX USA. [Trinh, Phuong D.] Montgomery Infect Dis Associates, Silver Spring, MD USA. [Vaccaro, Anthony] Northwestern Univ, Chicago, IL 60611 USA. [Valadas, Emilia] Hosp Santa Maria, Fac Med Lisboa, Lisbon, Portugal. [Vanig, Thanes J.] Spectrum Med Grp, Phoenix, AZ USA. [Vecino, Isabel; Weis, Steve] Univ N Texas, Hlth Sci Ctr, Ft Worth, TX USA. [Wade, Barbara H.] Infect Dis Associates NW Florida, Pensacola, FL USA. [Ward, Douglas J.] Dupont Circle Phys Grp, Washington, DC USA. [Weber, Robert D.] Infect Dis Specialists, Colorado Springs, CO USA. [Webster, Duncan] St Johns Hosp, St John, NB, Canada. [Wheeler, David A.] Clin Alliance Res & Educ Infect Dis, Annandale, VA USA. [White, David J.] Birmingham Heartlands Hosp, Birmingham B9 5ST, W Midlands, England. [Wilkins, Ed] N Manchester Grp Hosp, Manchester, Lancs, England. [Wright, David P.] Cent Texas Clin Res, Austin, TX USA. [Yurdin, David L.] Primary Hlth Care, Des Moines, IA USA. [Zabukovic, Brandon W.] Mem Neighborhood Hlth Ctr Cent Clin, South Bend, IN USA. [Zhao, Meng] United Hlth Serv Hosp, Binghamton, NY USA. [Pierce, Michael N.] All Med & Rehabil New York, Bronx, NY USA. RP Walker, BD (reprint author), Massachusetts Inst Technol & Harvard, Massachusetts Gen Hosp, Regon Inst, Boston, MA USA. EM pdebakker@rics.bwh.harvard.edu; bwalker@partners.org RI Robbins, Gregory/F-7988-2011; de Bakker, Paul/B-8730-2009; SHCS, all/G-4072-2011; SHCS, int. coll. A/G-4083-2011; Marconi, Vincent/N-3210-2014; OI de Bakker, Paul/0000-0001-7735-7858; Marconi, Vincent/0000-0001-8409-4689; Valadas, Emilia/0000-0001-5213-1473; Brumme, Chanson/0000-0003-2722-5288 FU Mark and Lisa Schwartz Foundation; Bill and Melinda Gates Foundation; Harvard University Center for AIDS Research [P-30-AI060354]; University of California San Francisco (UCSF) Center for AIDS Research [P-30 AI27763]; UCSF Clinical and Translational Science Institute [UL1 RR024131]; Center for AIDS Research Network of Integrated Clinical Systems [R24 AI067039]; NIH [AI28568, AI030914, AI087145, K24AI069994, AI069513, AI34835, AI069432, AI069423, AI069477, AI069501, AI069474, AI069428, AI69467, AI069415, Al32782, AI27661, AI25859, AI30914, AI069495, AI069471, AI069532, AI069452, AI069450, AI069556, AI069484, AI069472, AI069465, AI069511]; Swiss National Science Foundation (SNF) [33CSC0-108787, 310000-110012]; NIH/National Institute of Mental Health [MH085520]; National Cancer Institute/NIH [HHSN261200800001E]; NIH, National Cancer Institute, Center for Cancer Research FX This work was made possible through a generous donation from the Mark and Lisa Schwartz Foundation and a subsequent award from the Collaboration for AIDS Vaccine Discovery of the Bill and Melinda Gates Foundation. This work was also supported in part by the Harvard University Center for AIDS Research (grant P-30-AI060354); University of California San Francisco (UCSF) Center for AIDS Research (grant P-30 AI27763); UCSF Clinical and Translational Science Institute (grant UL1 RR024131); Center for AIDS Research Network of Integrated Clinical Systems (grant R24 AI067039); and NIH grants AI28568 and AI030914 (B. D. W.); AI087145 and K24AI069994 (S. G. D.); AI069513, AI34835, AI069432, AI069423, AI069477, AI069501, AI069474, AI069428, AI69467, AI069415, Al32782, AI27661, AI25859, AI28568, AI30914, AI069495, AI069471, AI069532, AI069452, AI069450, AI069556, AI069484, AI069472, AI34853, AI069465, AI069511, AI38844, AI069424, AI069434, AI46370, AI68634, AI069502, AI069419, AI068636, and RR024975 (AIDS Clinical Trials Group); and AI077505 and MH071205 (D. W. H.). The Swiss HIV Cohort Study is supported by the Swiss National Science Foundation (SNF grants 33CSC0-108787 and 310000-110012). S. Ripke acknowledges support from NIH/National Institute of Mental Health (grant MH085520). This project has been funded in whole or in part with funds from National Cancer Institute/NIH (grant HHSN261200800001E to M. Carrington). The content of this publication does not necessarily reflect the views or policies of the U. S. Department of Health and Human Services, nor does the mention of trade names, commercial products, or organizations imply endorsement by the U. S. government. This research was supported in part by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research. NR 31 TC 469 Z9 473 U1 5 U2 87 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 J9 SCIENCE JI Science PD DEC 10 PY 2010 VL 330 IS 6010 BP 1551 EP 1557 DI 10.1126/science.1195271 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 692LE UT WOS:000285153500069 ER PT J AU Akhvlediani, T Clark, DV Chubabria, G Zenaishvili, O Hepburn, MJ AF Akhvlediani, Tamar Clark, Danielle V. Chubabria, Giulen Zenaishvili, Otar Hepburn, Matthew J. TI The changing pattern of human brucellosis: clinical manifestations, epidemiology, and treatment outcomes over three decades in Georgia SO BMC INFECTIOUS DISEASES LA English DT Article ID EXPERIENCE; CHILDREN AB Background: Brucellosis is an endemic infection in Georgia. We conducted a review of patient records with a suspected or confirmed diagnosis of brucellosis over three decades at the central referral hospital for brucellosis cases, the Institute of Parasitology and Tropical Medicine (IPTM) in Tbilisi. The purpose was to describe the demographic profile and clinical characteristics as well as diagnostic and treatment strategies in patients with brucellosis. Methods: Data were abstracted from randomly selected patient records at the IPTM. In total, 300 records were reviewed from three time periods: 1970-73, 1988-89, and 2004-2008. Results: The age distribution of patients shifted from a median age of 40 years in the first time period to 20 years in the third time period. Azeri ethnicity was an increasing proportion of the total number of cases. The frequency of relapsed infection was 14.7% (44 cases). A total of 50 patients received vaccine therapy, and although the vaccine produced immune responses, demonstrated by an increase in agglutination titers, it was not associated with improved outcome. Conclusion: The demographics of brucellosis in Georgia fit a profile of persons that tend sheep. Osteoarticular complications were commonly detected, especially in children. The changing pattern of brucellosis in Georgia suggests clinicians should be updated about different trends in brucellosis in their country. C1 [Akhvlediani, Tamar] Technol Management Co, Clin Res Unit, Tbilisi, Rep of Georgia. [Clark, Danielle V.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Chubabria, Giulen; Zenaishvili, Otar] Inst Parasitol & Trop Med, Tbilisi, Rep of Georgia. [Hepburn, Matthew J.] USA, Med Res Inst Infect Dis, Frederick, MD USA. RP Akhvlediani, T (reprint author), Technol Management Co, Clin Res Unit, Tbilisi, Rep of Georgia. EM t_akhvlediani@yahoo.com FU US Department of Defense FX Funding for this project was provided by the US Department of Defense Cooperative Threat Reduction Program, implemented by the US Defense Threat Reduction Agency. The views of the authors do not purport to reflect the positions of the US Army or the US Department of Defense. This information was presented in part at the American Society of Microbiology Biodefense annual meeting, Baltimore Maryland USA, 22-25 February 2009, # 161. NR 24 TC 23 Z9 25 U1 1 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD DEC 9 PY 2010 VL 10 AR 346 DI 10.1186/1471-2334-10-346 PG 9 WC Infectious Diseases SC Infectious Diseases GA 697LD UT WOS:000285514200001 PM 21143881 ER PT J AU Chattopadhyay, R Velmurugan, S Chakiath, C Donkor, LA Milhous, W Barnwell, JW Collins, WE Hoffman, SL AF Chattopadhyay, Rana Velmurugan, Soundarapandian Chakiath, Chinnamma Donkor, Lucy Andrews Milhous, Wilbur Barnwell, John W. Collins, William E. Hoffman, Stephen L. TI Establishment of an In Vitro Assay for Assessing the Effects of Drugs on the Liver Stages of Plasmodium vivax Malaria SO PLOS ONE LA English DT Article ID EXOERYTHROCYTIC PARASITES; MOLECULAR ANALYSIS; INVITRO CULTURE; HYPNOZOITES; PRIMAQUINE; INFECTION; RELAPSES; ANTIBODIES; FALCIPARUM; VACCINE AB Plasmodium vivax (Pv) is the second most important human malaria parasite. Recent data indicate that the impact of Pv malaria on the health and economies of the developing world has been dramatically underestimated. Pv has a unique feature in its life cycle. Uninucleate sporozoites (spz), after invasion of human hepatocytes, either proceed to develop into tens of thousands of merozoites within the infected hepatocytes or remain as dormant forms called hypnozoites, which cause relapses of malaria months to several years after the primary infection. Elimination of malaria caused by Pv will be facilitated by developing a safe, highly effective drug that eliminates Pv liver stages, including hypnozoites. Identification and development of such a drug would be facilitated by the development of a medium to high throughput assay for screening drugs against Pv liver stages. We undertook the present pilot study to (1) assess the feasibility of producing large quantities of purified, vialed, cryopreserved Pv sporozoites and (2) establish a system for culturing the liver stages of Pv in order to assess the effects of drugs on the liver stages of Pv. We used primaquine (PQ) to establish this assay model, because PQ is the only licensed drug known to clear all Pv hepatocyte stages, including hypnozoites, and the effect of PQ on Pv hepatocyte stage development in vitro has not previously been reported. We report that we have established the capacity to reproducibly infect hepatoma cells with purified, cyropreserved Pv spz from the same lot, quantitate the primary outcome variable of infected hepatoma cells and demonstrate the inhibitory activity of primaquine on the infected hepatoma cells. We have also identified small parasite forms that may be hypnozoites. These data provide the foundation for finalizing a medium throughput, high content assay to identify new drugs for the elimination of all Pv liver stages. C1 [Chattopadhyay, Rana; Velmurugan, Soundarapandian; Chakiath, Chinnamma; Donkor, Lucy Andrews; Hoffman, Stephen L.] Sanaria Inc, Rockville, MD USA. [Milhous, Wilbur] Walter Reed Army Inst Res, Silver Spring, MD USA. [Barnwell, John W.; Collins, William E.] Ctr Dis Control & Prevent, CDC NCID Malaria Branch, Natl Ctr Infect Dis, Chamblee, GA USA. RP Chattopadhyay, R (reprint author), Sanaria Inc, Rockville, MD USA. EM slhoffman@sanaria.com FU Sanaria; Medicine for Malaria Venture FX Funding for this project was provided by a grant by Sanaria (www.sanaria.com) and Medicine for Malaria Venture (www.mmv.org). Sanaria, a for-profit organization, played a critical role in design, execution, analysis and publication of this work. MMV, a not-for-profit public-private partnership, participated in study design, but had no role in data collection and analysis, decision to publish, or preparation of the manuscript. NR 28 TC 30 Z9 30 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 9 PY 2010 VL 5 IS 12 AR e14275 DI 10.1371/journal.pone.0014275 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 692ES UT WOS:000285135800008 PM 21151554 ER PT J AU Gong, P Pirooznia, M Guan, X Perkins, EJ AF Gong, Ping Pirooznia, Mehdi Guan, Xin Perkins, Edward J. TI Design, Validation and Annotation of Transcriptome-Wide Oligonucleotide Probes for the Oligochaete Annelid Eisenia fetida SO PLOS ONE LA English DT Article ID GENE-EXPRESSION; MICROARRAY ANALYSIS; LARGE GENOMES; EARTHWORM; DISCOVERY; CLONING; BIOMARKERS; RESPONSES; EXPOSURE; CADMIUM AB High density oligonucleotide probe arrays have increasingly become an important tool in genomics studies. In organisms with incomplete genome sequence, one strategy for oligo probe design is to reduce the number of unique probes that target every non-redundant transcript through bioinformatic analysis and experimental testing. Here we adopted this strategy in making oligo probes for the earthworm Eisenia fetida, a species for which we have sequenced transcriptome-scale expressed sequence tags (ESTs). Our objectives were to identify unique transcripts as targets, to select an optimal and non-redundant oligo probe for each of these target ESTs, and to annotate the selected target sequences. We developed a streamlined and easy-to-follow approach to the design, validation and annotation of species-specific array probes. Four 244K-formatted oligo arrays were designed using eArray and were hybridized to a pooled E. fetida cRNA sample. We identified 63,541 probes with unsaturated signal intensities consistently above the background level. Target transcripts of these probes were annotated using several sequence alignment algorithms. Significant hits were obtained for 37,439 (59%) probed targets. We validated and made publicly available 63.5K oligo probes so the earthworm research community can use them to pursue ecological, toxicological, and other functional genomics questions. Our approach is efficient, cost-effective and robust because it (1) does not require a major genomics core facility; (2) allows new probes to be easily added and old probes modified or eliminated when new sequence information becomes available, (3) is not bioinformatics-intensive upfront but does provide opportunities for more in-depth annotation of biological functions for target genes; and (4) if desired, EST orthologs to the UniGene clusters of a reference genome can be identified and selected in order to improve the target gene specificity of designed probes. This approach is particularly applicable to organisms with a wealth of EST sequences but unfinished genome. C1 [Gong, Ping; Guan, Xin] SpecPro Inc, Environm Serv, Vicksburg, MS USA. [Pirooznia, Mehdi] Johns Hopkins Univ, Sch Med, Dept Psychiat, Baltimore, MD 21205 USA. [Perkins, Edward J.] USA, Army Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. RP Gong, P (reprint author), SpecPro Inc, Environm Serv, Vicksburg, MS USA. EM Ping.Gong@usace.army.mil OI Pirooznia, Mehdi/0000-0002-4210-6458 FU U.S. Army Engineer Research and Development Center (ERDC) FX This work was supported by the U.S. Army Environmental Quality Technology Basic Research Program of U.S. Army Engineer Research and Development Center (ERDC). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. SpecPro Inc. supported Ping Gong and Xin Guan through a contract granted by ERDC, and through this employment is considered by PLoS ONE to have played a role in the research. Permission to publish this information was granted by the Chief of Engineers. NR 54 TC 14 Z9 14 U1 3 U2 14 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 8 PY 2010 VL 5 IS 12 AR e14266 DI 10.1371/journal.pone.0014266 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 691MJ UT WOS:000285084100016 PM 21170345 ER PT J AU Li, X Barry, EA Zavada, JM Nardelli, MB Kim, KW AF Li, X. Barry, E. A. Zavada, J. M. Nardelli, M. Buongiorno Kim, K. W. TI Surface polar phonon dominated electron transport in graphene SO APPLIED PHYSICS LETTERS LA English DT Article ID TRANSISTORS AB The effects of surface polar phonons on the electronic transport properties of monolayer graphene are studied by using a Monte Carlo simulation. Specifically, the low-field electron mobility and saturation velocity are examined for different substrates (SiC, SiO2, and HfO2) in comparison to the intrinsic case. While the results show that the low-field mobility can be substantially reduced by the introduction of surface polar phonon scattering, corresponding degradation of the saturation velocity is not observed for all three substrates at room temperature. It is also found that surface polar phonons can influence graphene's electrical resistivity even at low temperature, leading potentially to inaccurate estimation of the acoustic phonon deformation potential constant. (C) 2010 American Institute of Physics. [doi:10.1063/1.3525606] C1 [Li, X.; Zavada, J. M.; Kim, K. W.] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. [Barry, E. A.] USA, Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Nardelli, M. Buongiorno] Oak Ridge Natl Lab, CSMD, Oak Ridge, TN 37831 USA. [Nardelli, M. Buongiorno] N Carolina State Univ, Dept Phys, Raleigh, NC 27695 USA. RP Li, X (reprint author), N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. EM kwk@ncsu.edu RI Buongiorno Nardelli, Marco/C-9089-2009 FU Defense Advanced Research Projects Agency/HRL Laboratories; U.S. Army Research Office; SRC Focus Center on Functional Engineered Nano Architectonics (FENA); Office of Basic Energy Sciences, U. S. DOE at Oak Ridge National Laboratory [DE-AC05-00OR22725]; UT-Battelle, LLC; NSF FX This work was supported, in part, by the Defense Advanced Research Projects Agency/HRL Laboratories (the CERA program), by the U.S. Army Research Office, and by the SRC Focus Center on Functional Engineered Nano Architectonics (FENA). M.B.N. wishes to acknowledge partial support from the Office of Basic Energy Sciences, U. S. DOE at Oak Ridge National Laboratory under Contract No. DE-AC05-00OR22725 with UT-Battelle, LLC. J.M.Z. acknowledges support from NSF under the IR/D program. NR 17 TC 56 Z9 56 U1 3 U2 17 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD DEC 6 PY 2010 VL 97 IS 23 AR 232105 DI 10.1063/1.3525606 PG 3 WC Physics, Applied SC Physics GA 695IO UT WOS:000285364000040 ER PT J AU Cho, Y Lee, W Jhon, YK Genzer, J Char, K AF Cho, Younghyun Lee, Woo Jhon, Young Kuk Genzer, Jan Char, Kookheon TI Polymer Nanotubules Obtained by Layer-by-Layer Deposition within AAO-Membrane Templates with Sub-100-nm Pore Diameters SO SMALL LA English DT Article ID POLYELECTROLYTE MULTILAYERS; WEAK POLYELECTROLYTE; BEHAVIOR; CHARGE; SALT C1 [Cho, Younghyun; Char, Kookheon] Seoul Natl Univ, Intelligent Hybrids Res Ctr, Sch Chem & Biol Engn, WCU Program Chem Convergence Energy & Environm, Seoul 151744, South Korea. [Lee, Woo] KRISS, Taejon 305600, South Korea. [Jhon, Young Kuk; Genzer, Jan] N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA. [Jhon, Young Kuk] USA, Div Chem Sci, Res Off, Durham, NC 27703 USA. RP Char, K (reprint author), Seoul Natl Univ, Intelligent Hybrids Res Ctr, Sch Chem & Biol Engn, WCU Program Chem Convergence Energy & Environm, Seoul 151744, South Korea. EM khchar@plaza.snu.ac.kr RI Lee, Woo/B-5268-2008 OI Lee, Woo/0000-0003-4560-8901 FU Korean Ministry of Education, Science and Technology (MEST) [2010-0018290]; NANO Systems Institute-National Core Research Center [R15-2003-032-05001-0]; WCU Program of C2E2 [R31-10013]; Seoul National University; Korean Ministry of Knowledge Economy (MKE) FX This work was financially supported by the National Research Foundation of Korea (NRF) Grant funded by the Korean Ministry of Education, Science and Technology (MEST) (The Creative Research Initiative Program (No. 2010-0018290), NANO Systems Institute-National Core Research Center (No. R15-2003-032-05001-0),The WCU Program of C2E2 (R31-10013) and graduate programs at Seoul National University through the BK 21 Program. We also acknowledge the financial support from the Korean Ministry of Knowledge Economy (MKE) on SystemIC2010 Project. We are also grateful to Dr. Laura Beth Dong and Prof. Geroge Roberts for DLS measurements. NR 39 TC 18 Z9 19 U1 1 U2 27 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 1613-6810 EI 1613-6829 J9 SMALL JI Small PD DEC 6 PY 2010 VL 6 IS 23 BP 2683 EP 2689 DI 10.1002/smll.201001212 PG 7 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 698BA UT WOS:000285565300011 PM 21072868 ER PT J AU Edmonds, TG Ding, HT Yuan, X Wei, Q Smith, KS Conway, JA Wieczorek, L Brown, B Polonis, V West, JT Montefiori, DC Kappes, JC Ochsenbauer, C AF Edmonds, Tara G. Ding, Haitao Yuan, Xing Wei, Qing Smith, Kendra S. Conway, Joan A. Wieczorek, Lindsay Brown, Bruce Polonis, Victoria West, John T. Montefiori, David C. Kappes, John C. Ochsenbauer, Christina TI Replication competent molecular clones of HIV-1 expressing Renilla luciferase facilitate the analysis of antibody inhibition in PBMC SO VIROLOGY LA English DT Article DE HIV-1; Neutralizing antibody; PBMC assay; HIV reporter virus; Vaccine assessment; Assay standardization; HIV neutralization; Luciferase; Envelope glycoprotein ID IMMUNODEFICIENCY-VIRUS TYPE-1; NEUTRALIZING ANTIBODIES; MONOCLONAL-ANTIBODIES; IN-VITRO; ENVELOPE GLYCOPROTEIN; VIRION INCORPORATION; DRUG SUSCEPTIBILITY; CHIMERIC VIRUS; TARGET-CELLS; ENV CLONES AB Effective vaccine development for human immunodeficiency virus type 1 (HIV-1) will require assays that ascertain the capacity of vaccine immunogens to elicit neutralizing antibodies (NAb) to diverse HIV-1 strains. To facilitate NAb assessment in peripheral blood mononuclear cell (PBMC)-based assays, we developed an assay-adaptable platform based on a Renilla luciferase (LucR) expressing HIV-1 proviral backbone. LucR was inserted into pNL4-3 DNA, preserving all viral open reading frames. The proviral genome was engineered to facilitate expression of diverse HIV-1 env sequences, allowing analysis in an isogenic background. The resulting Env-IMC-LucR viruses are infectious, and LucR is stably expressed over multiple replications in PBMC. HIV-1 neutralization, targeting TZM-bl cells, was highly correlative comparing virus (LucR) and cell (firefly luciferase) readouts. In PBMC, NAb activity can be analyzed either within a single or multiple cycles of replication. These results represent advancement toward a standardizable PBMC-based neutralization assay for assessing HIV-1 vaccine immunogen efficacy. (C) 2010 Elsevier Inc. All rights reserved. C1 [Ding, Haitao; Wei, Qing; Smith, Kendra S.; Conway, Joan A.; Kappes, John C.; Ochsenbauer, Christina] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA. [Edmonds, Tara G.; Kappes, John C.] Univ Alabama Birmingham, Dept Mol & Cellular Pathol, Birmingham, AL 35294 USA. [Kappes, John C.] Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA. [Kappes, John C.] Birmingham Vet Affairs Med Ctr, Res Serv, Birmingham, AL 35233 USA. [Yuan, Xing; Montefiori, David C.] Duke Univ, Med Ctr, Durham, NC 27710 USA. [West, John T.] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK 73104 USA. [Wieczorek, Lindsay; Brown, Bruce] Henry M Jackson Fdn, Rockville, MD 20850 USA. [Wieczorek, Lindsay; Brown, Bruce; Polonis, Victoria] Walter Reed Army Inst Res, US Mil HIV Res Program MHRP, Rockville, MD 20850 USA. RP Ochsenbauer, C (reprint author), Univ Alabama Birmingham, Dept Med, 701 19th St S,LHRB 613, Birmingham, AL 35294 USA. EM edmondst@uab.edu; Haitao.Ding@ccc.uab.edu; qingwei@uab.edu; ceasmi@uab.edu; conwayj@uab.edu; lwieczorek@hivresearch.org; bbrown@hivresearch.org; vpolonis@hivresearch.org; john-west@ouhsc.edu; monte@duke.edu; John.Kappes@ccc.uab.edu; ochsenba@uab.edu FU NIH Center for HIV/AIDS Vaccine Immunology (CHAVI) [UO1-AI067854]; Bill & Melinda Gates Foundation's Collaboration for AIDS Vaccine Discovery (CAVD)/Comprehensive Antibody Vaccine Immune Monitoring Consortium (CAVIMC) [38619]; UAB Center for AIDS Research [P30-AI-27767]; UAB Mucosal HIV and Immunobiology Center [R24 DK-64400]; Department of Veterans Affairs Medical Center, Research Services; NIH [AI007439]; Statistical Center for HIV/AIDS Research and Prevention (SCHARP), Fred Hutchinson Cancer Research Center, Seattle, WA FX This work was supported by the NIH Center for HIV/AIDS Vaccine Immunology (CHAVI), UO1-AI067854; the Bill & Melinda Gates Foundation's Collaboration for AIDS Vaccine Discovery (CAVD)/Comprehensive Antibody Vaccine Immune Monitoring Consortium (CAVIMC), grant number 38619; facilities of the Virology and Genetic Sequencing cores of the UAB Center for AIDS Research (P30-AI-27767); and the Genetically Defined Microbe and Expression Core of the UAB Mucosal HIV and Immunobiology Center (R24 DK-64400). Research was also supported by a Merit Review Award (JCK), from the Department of Veterans Affairs Medical Center, Research Services. TGE is supported by NIH training grant AI007439. We would like to acknowledge the expertise and support we obtained from the Statistical Center for HIV/AIDS Research and Prevention (SCHARP), Fred Hutchinson Cancer Research Center, Seattle, WA. NR 69 TC 97 Z9 97 U1 0 U2 5 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD DEC 5 PY 2010 VL 408 IS 1 BP 1 EP 13 DI 10.1016/j.viro1.2010.08.028 PG 13 WC Virology SC Virology GA 677DY UT WOS:000283970500001 PM 20863545 ER PT J AU Borges, AR Wieczorek, L Johnson, B Benesi, AJ Brown, BK Kensinger, RD Krebs, FC Wigdahl, B Blumenthal, R Puri, A McCutchan, FE Birx, DL Polonis, VR Schengrund, CL AF Borges, Andrew Rosa Wieczorek, Lindsay Johnson, Benitra Benesi, Alan J. Brown, Bruce K. Kensinger, Richard D. Krebs, Fred C. Wigdahl, Brian Blumenthal, Robert Puri, Anu McCutchan, Francine E. Birx, Deborah L. Polonis, Victoria R. Schengrund, Cara-Lynne TI Multivalent dendrimeric compounds containing carbohydrates expressed on immune cells inhibit infection by primary isolates of HIV-1 SO VIROLOGY LA English DT Article DE Human immunodeficiency virus-1; Multivalent carbohydrates; 3 '-sialyllactose; Globotriose; Peripheral blood mononuclear cells; T cell lines ID HUMAN-IMMUNODEFICIENCY-VIRUS; BLOOD MONONUCLEAR-CELLS; GANGLIOSIDE GM3; ENVELOPE GLYCOPROTEIN; V3 LOOP; SURFACE GLYCOSPHINGOLIPIDS; MEMBRANE MICRODOMAINS; MONOCLONAL-ANTIBODIES; GALACTOSYL CERAMIDE; TYPE-1 INFECTION AB Specific glycosphingolipids (GSL), found on the surface of target immune cells, are recognized as alternate cell surface receptors by the human immunodeficiency virus type 1 (HIV-1) external envelope glycoprotein. In this study, the globotriose and 3'-sialyllactose carbohydrate head groups found on two GSL were covalently attached to a dendrimer core to produce two types of unique multivalent carbohydrates (MVC). These MVC inhibited HIV-1 infection of T cell lines and primary peripheral blood mononuclear cells (PBMC) by T cell line-adapted viruses or primary isolates, with IC(50)s ranging from 0.1 to 7.4 mu g/ml. Inhibition of Env-mediated membrane fusion by MVC was also observed using a dye-transfer assay. These carbohydrate compounds warrant further investigation as a potential new class of HIV-1 entry inhibitors. The data presented also shed light on the role of carbohydrate moieties in HIV-1 virus-host cell interactions. (C) 2010 Elsevier Inc. All rights reserved. C1 [Borges, Andrew Rosa; Wieczorek, Lindsay; Brown, Bruce K.; McCutchan, Francine E.] Henry M Jackson Fdn, Mil HIV Res Program, Rockville, MD 20850 USA. [Johnson, Benitra; Blumenthal, Robert; Puri, Anu] NCI, Ctr Canc Res, NIH, Frederick, MD 21701 USA. [Benesi, Alan J.] Penn State Univ, Dept Chem, State Coll, PA USA. [Kensinger, Richard D.; Schengrund, Cara-Lynne] Penn State Univ, Coll Med, Dept Biochem & Mol Biol, Hershey, PA USA. [Krebs, Fred C.; Wigdahl, Brian] Drexel Univ, Coll Med, Dept Microbiol & Immunol, Philadelphia, PA 19104 USA. [Birx, Deborah L.; Polonis, Victoria R.] Walter Reed Army Inst Res, Mil HIV Res Program, Div Retrovirol, Rockville, MD USA. RP Schengrund, CL (reprint author), Penn State Coll Med, Dept Biochem & Mol Biol, 500 Univ Dr, Hershey, PA 17033 USA. EM cxs8@psu.edu FU National Institute of Allergy and Infectious Diseases [RO1 NS40231]; NIH, National Cancer Institute, Center for Cancer Research; U.S. Army Medical Research and Material Command [DAMD W81XWH-04-2-0005]; Henry M. Jackson Foundation for the Advancement of Military Medicine [DAMD W81XWH-04-2-0005] FX This work was supported in part by grant RO1 NS40231 from the National Institute of Allergy and Infectious Diseases (CLS), the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research (AP and RB), and by Cooperative Agreement no. DAMD W81XWH-04-2-0005 between the U.S. Army Medical Research and Material Command and the Henry M. Jackson Foundation for the Advancement of Military Medicine, working with the Division of AIDS, National Institute for Allergy and Infectious Diseases, National Institutes of Health. NR 80 TC 18 Z9 18 U1 0 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD DEC 5 PY 2010 VL 408 IS 1 BP 80 EP 88 DI 10.1016/j.virol.2010.09.004 PG 9 WC Virology SC Virology GA 677DY UT WOS:000283970500009 ER PT J AU Valiyaveettil, M Alamneh, Y Biggernann, L Soojhawon, I Doctor, BP Nambiar, MP AF Valiyaveettil, Manojkumar Alamneh, Yonas Biggernann, Lionel Soojhawon, Iswarduth Doctor, Bhupendra P. Nambiar, Madhusoodana P. TI Efficient hydrolysis of the chemical warfare nerve agent tabun by recombinant and purified human and rabbit serum paraoxonase 1 SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS LA English DT Article DE Catalytic bioscavenger; Paraoxonase 1; Chemical warfare nerve agents; Prophylaxis; Medical chemical defense; Tabun ID ORGANOPHOSPHATE TOXICITY; DIISOPROPYL PHOSPHOROFLUORIDATE; ENZYMATIC-HYDROLYSIS; GUINEA-PIGS; SOMAN; SARIN; BUTYRYLCHOLINESTERASE; CHLORPYRIFOS; ARYLESTERASE; PRETREATMENT AB Paraoxonase 1 (PON1) has been described as an efficient catalytic bioscavenger due to its ability to hydrolyze organophosphates (OPs) and chemical warfare nerve agents (CWNAs). It is the future most promising candidate as prophylactic medical countermeasure against highly toxic OPs and CWNAs. Most of the studies conducted so far have been focused on the hydrolyzing potential of PON1 against nerve agents, sarin, soman, and VX. Here, we investigated the hydrolysis of tabun by PON1 with the objective of comparing the hydrolysis potential of human and rabbit serum purified and recombinant human PON1. The hydrolysis potential of PON1 against tabun, sarin, and soman was evaluated by using an acetylcholinesterase (AChE) back-titration Ellman method. Efficient hydrolysis of tabun (100 nM) was observed with similar to 25-40 mU of PON1, while higher concentration (80-250 mU) of the enzyme was required for the complete hydrolysis of sarin (11 nM) and soman (3 nM). Our data indicate that tabun hydrolysis with PON1 was similar to 30-60 times and similar to 200-260 times more efficient than that with sarin and soman, respectively. Moreover, the catalytic activity of PON1 varies from source to source, which also reflects their efficiency of hydrolyzing different types of nerve agents. Thus, efficient hydrolysis of tabun by PON1 suggests its promising potential as a prophylactic treatment against tabun exposure. Published by Elsevier Inc. C1 [Valiyaveettil, Manojkumar; Alamneh, Yonas; Biggernann, Lionel; Soojhawon, Iswarduth; Doctor, Bhupendra P.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Closed Head Injury Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Valiyaveettil, M (reprint author), Walter Reed Army Inst Res, Closed Head Injury Branch, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM m.valiyaveettil@amedd.army.mil; madhu-soodana.nambiar@amedd.army.mil FU Defense Threat Reduction Agency (DTRA) [1.D0017_08_WR_C] FX This work was supported by funding from Defense Threat Reduction Agency (DTRA) Grant # 1.D0017_08_WR_C. The technical assistance from Peter Rezk and Dr. Michael Perkins from USAMRICD is greatly acknowledged. We are really thankful to Dr. Alfred M. Sciuto, USAMRICD, for his collaboration and valuable suggestions. NR 29 TC 14 Z9 15 U1 2 U2 22 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0006-291X J9 BIOCHEM BIOPH RES CO JI Biochem. Biophys. Res. Commun. PD DEC 3 PY 2010 VL 403 IS 1 BP 97 EP 102 DI 10.1016/j.bbrc.2010.10.125 PG 6 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 693LV UT WOS:000285226500017 PM 21040699 ER PT J AU Villines, TC Devine, PJ Cheezum, MK Gibbs, B Feuerstein, IM Welch, TS AF Villines, Todd C. Devine, Patrick J. Cheezum, Michael K. Gibbs, Barnett Feuerstein, Irwin M. Welch, Timothy S. TI Incidence of anomalous coronary artery origins in 577 consecutive adults undergoing cardiac CT angiography SO INTERNATIONAL JOURNAL OF CARDIOLOGY LA English DT Letter DE Cardiac computed tomography; Coronary computed tomography angiography; Coronary artery anomaly ID COMPUTED-TOMOGRAPHY; SUDDEN-DEATH C1 [Villines, Todd C.; Devine, Patrick J.; Gibbs, Barnett; Welch, Timothy S.] Walter Reed Army Med Ctr, Dept Med, Serv Cardiol, Washington, DC 20307 USA. [Cheezum, Michael K.] Walter Reed Army Med Ctr, Dept Med, Internal Med Serv, Washington, DC 20307 USA. [Feuerstein, Irwin M.] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. RP Villines, TC (reprint author), Walter Reed Army Med Ctr, Dept Med, Serv Cardiol, Bldg 2,Room 4A-34A,6900 Georgia Ave,NW, Washington, DC 20307 USA. EM todd.villines@amedd.army.mil OI Villines, Todd/0000-0003-2674-3702 NR 11 TC 2 Z9 2 U1 0 U2 1 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0167-5273 J9 INT J CARDIOL JI Int. J. Cardiol. PD DEC 3 PY 2010 VL 145 IS 3 BP 525 EP 526 DI 10.1016/j.ijcard.2010.04.059 PG 2 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 692EU UT WOS:000285136200048 PM 20451266 ER PT J AU Stephenson, LD Lawrence, D Kumar, A AF Stephenson, L. D. Lawrence, Debbie Kumar, Ashok TI Corrosion Inhibitors for Rebar in Concrete-Part 1 SO MATERIALS PERFORMANCE LA English DT Article AB Two types of emerging technologies to mitigate corrosion in existing reinforced concrete structures were demonstrated at military installations in highly corrosive environments. The first consisted of surface-applied corrosion inhibitors, while the second was a surface-applied sacrificial cathodic protection coating. This article describes the evaluation of the demonstration structures. Part 2 (to be published in January 2011 MP) will cover the inhibitor applications and results. C1 [Stephenson, L. D.; Lawrence, Debbie; Kumar, Ashok] USA, Corps Engineers, ERDC, CERL, Champaign, IL 61828 USA. RP Stephenson, LD (reprint author), USA, Corps Engineers, ERDC, CERL, POB 9005, Champaign, IL 61828 USA. FU U.S. Department of Defense; Office of Under Secretary of Defense, Office of Corrosion Policy and Oversight FX The authors wish to recognize the sponsors of the U.S. Department of Defense (Doll) Corrosion Prevention and Control Program: Office of Under Secretary of Defense, Office of Corrosion Policy and Oversight (Director, Dan Dunmire); Deputy Assistant Secretary of the Army Acquisition Policy and Logistics (Army Corrosion Control Prevention Executive, Wimpy D. Pybus); Assistant Chief of Staff for Installation Management (Paul Richardson); and Headquarters, U.S. Army Installation Management Command (Ishmael Melendez). The authors also wish to acknowledge the contributions of Surtreat, EEC, for their on-site support for this project. NR 3 TC 0 Z9 0 U1 0 U2 0 PU NATL ASSOC CORROSION ENG PI HOUSTON PA 1440 SOUTH CREEK DRIVE, HOUSTON, TX 77084-4906 USA SN 0094-1492 J9 MATER PERFORMANCE JI Mater. Perform. PD DEC PY 2010 VL 49 IS 12 BP 50 EP 53 PG 4 WC Materials Science, Characterization & Testing SC Materials Science GA 826WJ UT WOS:000295386000010 ER PT J AU Merriam, JJ AF Merriam, John J. TI NATURAL LAW AND SELF-DEFENSE SO MILITARY LAW REVIEW LA English DT Article C1 [Merriam, John J.] USA, Washington, DC 20310 USA. [Merriam, John J.] 12th Combat Aviat Brigade, Ansbach, Germany. [Merriam, John J.] 1st Brigade, Infantry Div 25, Ft Lewis, WA USA. [Merriam, John J.] 1st Brigade, Infantry Div 25, Mosul, Iraq. [Merriam, John J.] I Corps, Int & Operat Law, Ft Lewis, WA USA. RP Merriam, JJ (reprint author), 10th Special Forces Grp Airborne, Ft Carson, CO 80913 USA. NR 47 TC 1 Z9 1 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2010 VL 206 BP 43 EP 87 PG 45 WC Law SC Government & Law GA 801JP UT WOS:000293435100002 ER PT J AU Berry, JF AF Berry, Joshua F. TI HOLLOW POINT BULLETS: HOW HISTORY HAS HIJACKED THEIR USE IN COMBAT AND WHY IT IS TIME TO REEXAMINE THE 1899 HAGUE DECLARATION CONCERNING EXPANDING BULLETS SO MILITARY LAW REVIEW LA English DT Article C1 [Berry, Joshua F.] USA, Washington, DC 20310 USA. [Berry, Joshua F.] III Corps & Ft Hood, Off Staff Judge Advocate, Ft Hood, TX USA. [Berry, Joshua F.] Multinatl Corps Iraq, Baghdad, Iraq. [Berry, Joshua F.] 1st Battal, Field Artillery 82D, Cavalry Div 1, Ft Hood, TX USA. RP Berry, JF (reprint author), 160th Special Operat Aviat Regiment Airborne, Ft Campbell, KY 42223 USA. NR 100 TC 1 Z9 1 U1 0 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2010 VL 206 BP 88 EP 156 PG 69 WC Law SC Government & Law GA 801JP UT WOS:000293435100003 ER PT J AU Nestler, JM Theiling, CH Lubinski, KS Smith, DL AF Nestler, John M. Theiling, Charles H. Lubinski, Kenneth S. Smith, David L. TI REFERENCE CONDITION APPROACH TO RESTORATION PLANNING SO RIVER RESEARCH AND APPLICATIONS LA English DT Article DE reference condition; Upper Mississippi River; restoration planning; restoration framework; large river restoration; river hydrology ID MISSISSIPPI RIVER; HYDROLOGIC ALTERATION; ECOSYSTEM MANAGEMENT; ADAPTIVE MANAGEMENT; SCALE; INTEGRITY; REGIME; NEED AB Ecosystem restoration planning requires quantitative rigor to evaluate alternatives, define end states, report progress and perform environmental benefits analysis (EBA). Unfortunately, existing planning frameworks are, at best, semi-quantitative. In this paper, we: (1) describe a quantitative restoration planning approach based on a comprehensive, but simple mathematical framework that can be used to effectively apply knowledge and evaluate alternatives, (2) use the approach to derive a simple but precisely defined lexicon based on the reference condition concept and allied terms and (3) illustrate the approach with an example from the Upper Mississippi River System (UMRS) using hydrologic indicators. The approach supports the development of a scaleable restoration strategy that, in theory, can be expanded to ecosystem characteristics such as hydraulics, geomorphology, habitat and biodiversity. We identify three reference condition types, best achievable condition (A(BAC)), measured magnitude (MMi which can be determined at one or many times and places) and desired future condition (A(DFC)) that, when used with the mathematical framework, provide a complete system of accounts useful for goal-oriented system-level management and restoration. Published in 2010 by John Wiley & Sons, Ltd. C1 [Nestler, John M.; Smith, David L.] USA, Environm Lab, Engn Res & Dev Ctr, CEERD EP W, Vicksburg, MS 39180 USA. [Theiling, Charles H.] USA, Corps Engineers, Rock Isl, IL 61204 USA. [Lubinski, Kenneth S.] US Geol Survey, Upper Midwest Environm Sci Ctr, La Crosse, WI 54603 USA. RP Nestler, JM (reprint author), USA, Environm Lab, Engn Res & Dev Ctr, CEERD EP W, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM john.m.nestler@usace.army.mil FU U.S. Army Engineer District, Rock Island; System-Wide Water Resources Program (SWWRP) FX We acknowledge Dr Luther Aadland (Minnesota Department of Natural Resources) for sharing ideas on a parsimonious, clear and persuasive definition of restoration. We appreciate discussions by members of the UMRS Science Panel that crystallized the NESP restoration issues to the point where they could be formalized for a mathematical treatment. Toni Toney (U.S. Army Engineer Research and Development Center) and Mike Davis (Minnesota Department of Natural Resources) provided technical reviews of the paper. The tests described and the resulting data presented herein, unless otherwise noted, were obtained from research conducted under the sponsorship of the U.S. Army Engineer District, Rock Island (who manages the NESP) and the System-Wide Water Resources Program (SWWRP). Permission was granted by the Chief of Engineers to publish this information. NR 60 TC 14 Z9 14 U1 4 U2 24 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 1535-1459 J9 RIVER RES APPL JI River Res. Appl. PD DEC PY 2010 VL 26 IS 10 BP 1199 EP 1219 DI 10.1002/rra.1330 PG 21 WC Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA 694RE UT WOS:000285314500001 ER PT J AU Gulledge, T Hiroshige, S Iyer, R AF Gulledge, Thomas Hiroshige, Scott Iyer, Raj TI Condition-based Maintenance and the product improvement process SO COMPUTERS IN INDUSTRY LA English DT Article DE Condition-based Maintenance (CBM); Product Lifecycle Management (PLM); Composite applications; Service-oriented architecture (SOA) AB The evolution of enterprise services is changing the approach for enabling Product Lifecycle Management (PLM) and Supply Chain Management (SCM) business processes. Enabling systems are migrating to process- and service-oriented solutions. In particular, the paper demonstrates how the new technologies can be used to enable a critical process that links vehicle health maintenance to PLM. Our hypothesis is that Condition-based Maintenance (CBM) and PLM integration is achievable through composite application design. The key process for linking CBM to PLM must convert prognostic and diagnostic information into actionable information that can be directed into a project-level PLM environment that supports the end-to-end product improvement process. To test this hypothesis, we designed a composite application within the context of a Small Business Innovative Research project that is sponsored by the US government. This paper motivates the problem from the strategic level to the implementation level and describes the successful test of the hypothesis. (C) 2010 Elsevier B.V. All rights reserved. C1 [Gulledge, Thomas; Hiroshige, Scott] Enterprise Integrat Inc, Alexandria, VA 22315 USA. [Iyer, Raj] USA, TACOM LCMC, Warren, MI 48397 USA. RP Hiroshige, S (reprint author), Enterprise Integrat Inc, 5901 Kingstowne Village Pkwy,Suite 304, Alexandria, VA 22315 USA. EM thomas.gulledge@eiisolutions.net; scott.hiroshige@eiisolutions.net; raj.iyer@us.army.mil NR 17 TC 9 Z9 9 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3615 J9 COMPUT IND JI Comput. Ind. PD DEC PY 2010 VL 61 IS 9 SI SI BP 813 EP 832 DI 10.1016/j.compind.2010.07.007 PG 20 WC Computer Science, Interdisciplinary Applications SC Computer Science GA 696MS UT WOS:000285446100003 ER PT J AU Hammond, RT AF Hammond, Richard T. TI THE NECESSITY OF TORSION IN GRAVITY SO INTERNATIONAL JOURNAL OF MODERN PHYSICS D LA English DT Article ID MASS REVERSAL AB It is shown that torsion is required for a complete theory of graviation, and that without it, the equations of gravitation violate fundamental laws. In the first case, we are reminded that, in the absence of external forces, the correct conservation law of total angular momentum arises only if torsion, whose origin is intrinsic spin, is included into gravitation. The second case considers the "mass reversal" transformation. It has been known that under a global chiral transformation and "mass to negative mass" transformation, the Dirac equation is invariant. But global transformations violate special relativity, so this transformation must be made local. It is shown that the torsion is the gauge field for this local invariance. C1 [Hammond, Richard T.] Univ N Carolina, Dept Phys, Chapel Hill, NC 27515 USA. [Hammond, Richard T.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Hammond, RT (reprint author), Univ N Carolina, Dept Phys, Chapel Hill, NC 27515 USA. EM rhammond@email.unc.edu NR 9 TC 1 Z9 1 U1 1 U2 3 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE SN 0218-2718 J9 INT J MOD PHYS D JI Int. J. Mod. Phys. D PD DEC PY 2010 VL 19 IS 14 BP 2413 EP 2416 DI 10.1142/S0218271810018554 PG 4 WC Astronomy & Astrophysics SC Astronomy & Astrophysics GA 705EP UT WOS:000286112000027 ER PT J AU Darlington, D Fedyk, C Scherer, M Delgado, A Concepts, K Kheirabadi, B Pusateri, A Wade, C Cap, A Dubick, M AF Darlington, Daniel Fedyk, Chriselda Scherer, Michael Delgado, Angel Concepts, Kinetic Kheirabadi, Bijan Pusateri, Anthony Wade, Charles Cap, Andrew Dubick, Michael TI HEMODILUTION EFFECTS COAGULATION OF HUMAN BLOOD EX VIVO SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 40th Critical Care Congress CY JAN 15-19, 2011 CL San Diego, CA SP Soc Crit Care Med C1 [Darlington, Daniel; Fedyk, Chriselda; Scherer, Michael; Delgado, Angel; Concepts, Kinetic; Kheirabadi, Bijan; Pusateri, Anthony; Cap, Andrew; Dubick, Michael] USA, ISR, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2010 VL 38 IS 12 SU S MA 134 BP U37 EP U37 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 684BA UT WOS:000284520800128 ER PT J AU Dennis, C Yoon, B Holland, S Milligan, D Chung, K AF Dennis, Christopher Yoon, Brian Holland, Seth Milligan, Daun Chung, Kevin TI RISK FACTORS FOR HYPOTENSION FOLLOWING URGENT INTUBATION IN A BURN INTENSIVE CARE UNIT SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 40th Critical Care Congress CY JAN 15-19, 2011 CL San Diego, CA SP Soc Crit Care Med C1 [Dennis, Christopher; Milligan, Daun] San Antonio Mil Med Ctr, San Antonio, TX USA. [Chung, Kevin] USA, Inst Surg Res, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2010 VL 38 IS 12 SU S MA 577 BP U179 EP U179 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 684BA UT WOS:000284520801064 ER PT J AU Dubick, M Darlington, D Kheirabadi, B Fedyk, C Scherer, M Kremenevskiy, I Delgado, A Concepts, K Pusateri, A AF Dubick, Michael Darlington, Daniel Kheirabadi, Bijan Fedyk, Chriselda Scherer, Michael Kremenevskiy, Igor Delgado, Angel Concepts, Kinetic Pusateri, Anthony TI THE EFFECT OF RFVIIA ON THROMBIN GENERATION OF MODERATELY DILUTED AND HYPOTHERMIC HUMAN BLOOD EX VIVO SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 40th Critical Care Congress CY JAN 15-19, 2011 CL San Diego, CA SP Soc Crit Care Med C1 [Dubick, Michael; Darlington, Daniel; Kheirabadi, Bijan; Fedyk, Chriselda; Scherer, Michael; Kremenevskiy, Igor; Delgado, Angel; Concepts, Kinetic; Pusateri, Anthony] USA, Inst Surg Res, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2010 VL 38 IS 12 SU S MA 133 BP U37 EP U37 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 684BA UT WOS:000284520800127 ER PT J AU Gibson, D Shields, B Chung, K Wolf, S AF Gibson, Drew Shields, Beth Chung, Kevin Wolf, Steven TI INTERRUPTION DURING THE INITIATION OF ENTERAL NUTRITION AFTER BURN INJURY DOES NOT RESULT IN INTOLERANCE SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 40th Critical Care Congress CY JAN 15-19, 2011 CL San Diego, CA SP Soc Crit Care Med C1 [Gibson, Drew; Chung, Kevin] USAISR, Ft Sam Houston, TX USA. [Shields, Beth] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Wolf, Steven] Univ Texas Hlth Sci, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2010 VL 38 IS 12 SU S MA 270 BP U75 EP U75 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 684BA UT WOS:000284520800254 ER PT J AU Jambhekar, A Mora, A Jones, J Wade, C Wolf, S AF Jambhekar, Amani Mora, Alejandra Jones, John Wade, Charles Wolf, Steven TI HYPOTHERMIC EVENTS IN A BURN ICU INCREASE MORTALITY RISKS SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 40th Critical Care Congress CY JAN 15-19, 2011 CL San Diego, CA SP Soc Crit Care Med C1 [Jambhekar, Amani; Mora, Alejandra; Jones, John] USA, Inst Surg Res, Washington, DC USA. [Wade, Charles] Univ Texas Hlth Sci Ctr Houston, Houston, TX USA. [Wolf, Steven] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2010 VL 38 IS 12 SU S MA 527 BP U164 EP U164 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 684BA UT WOS:000284520801015 ER PT J AU Reilly, S Pamplin, J Pineda, L Hebert, R Marquez, D Chung, K AF Reilly, Sean Pamplin, Jeremy Pineda, Louie Hebert, Rebecca Marquez, Deborah Chung, Kevin TI DECREASED RATES OF CODE TEAM ACTIVATION FOLLOWING THE INTRODUCTION OF RAPID RESPONSE TEAMS TO AN ACADEMIC MILITARY MEDICAL CENTER SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 40th Critical Care Congress CY JAN 15-19, 2011 CL San Diego, CA SP Soc Crit Care Med C1 [Reilly, Sean] USA, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2010 VL 38 IS 12 SU S MA 107 BP U28 EP U28 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 684BA UT WOS:000284520800102 ER PT J AU Schlussel, A Holt, D Crawley, E Uyehara, C AF Schlussel, Andrew Holt, Danielle Crawley, Eric Uyehara, Catherine TI EFFECTS OF HYPERGLYCEMIA AND CONTINUOUS INTRAVENOUS INSULIN ON OUTCOMES OF SURGICAL PATIENTS SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 40th Critical Care Congress CY JAN 15-19, 2011 CL San Diego, CA SP Soc Crit Care Med C1 [Schlussel, Andrew; Holt, Danielle; Crawley, Eric; Uyehara, Catherine] Tripler Army Med Ctr, Honolulu, HI USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2010 VL 38 IS 12 SU S MA 249 BP U70 EP U70 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 684BA UT WOS:000284520800233 ER PT J AU Shellington, D Jenkins, L Bauman, R Swauger, P Parks, S Dixon, CE Bayir, H Jackson, E Garman, R Kochanek, P AF Shellington, David Jenkins, Larry Bauman, Richard Swauger, Peter Parks, Steven Dixon, C. Edward Bayir, Hulya Jackson, Edwin Garman, Robert Kochanek, Patrick TI BLAST OVERPRESSURE INJURY IN RATS WITH BODY PROTECTION INCREASES PRO-INFLAMMATORY BRAIN CYTOKINE CONCENTRATIONS SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 40th Critical Care Congress CY JAN 15-19, 2011 CL San Diego, CA SP Soc Crit Care Med C1 [Shellington, David; Bayir, Hulya] Childrens Hosp Pittsburgh, Pittsburgh, PA USA. [Jenkins, Larry; Dixon, C. Edward] Univ Pittsburgh, Sch Med, Pittsburgh, PA 15260 USA. [Bauman, Richard] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Kochanek, Patrick/D-2371-2015 OI Kochanek, Patrick/0000-0002-2627-913X NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2010 VL 38 IS 12 SU S MA 143 BP U41 EP U41 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 684BA UT WOS:000284520800135 ER PT J AU Shields, B Gibson, D Wolf, S AF Shields, Beth Gibson, Drew Wolf, Steven TI PREDICTING ENTERAL FEEDING INTOLERANCE SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 40th Critical Care Congress CY JAN 15-19, 2011 CL San Diego, CA SP Soc Crit Care Med C1 [Shields, Beth] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Gibson, Drew] USAISR, Ft Sam Houston, TX USA. [Wolf, Steven] Univ Texas Hlth Sci, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2010 VL 38 IS 12 SU S MA 271 BP U75 EP U75 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 684BA UT WOS:000284520800253 ER PT J AU Dongare, AM Rajendran, AM LaMattina, B Zikry, MA Brenner, DW AF Dongare, Avinash M. Rajendran, Arunachalam M. LaMattina, Bruce Zikry, Mohammed A. Brenner, Donald W. TI Atomic scale studies of spall behavior in nanocrystalline Cu SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID VOID GROWTH; STRAIN-RATE; DUCTILE FRACTURE; COPPER; SOLIDS; METALS; NUCLEATION; SIMULATION; PRESSURE; STRENGTH AB The micromechanisms related to ductile failure during dynamic loading of nanocrystalline Cu are investigated in a series of large-scale molecular dynamics simulations. Void nucleation, growth, and coalescence is studied for a nanocrystalline Cu system with an average grain size of 6 nm under conditions of impact of a shock piston with velocities of 250, 500, 750, and 1000 m/s and compared to that observed in single crystal copper. Higher impact velocities result in higher strain rates and higher values of spall strengths for the metal as well as nucleation of larger number of voids in smaller times. For the same impact velocity, the spall strength of the nanocrystalline metal, however, is lower than that for single crystal copper. The results obtained for void nucleation and growth in nanocrystalline Cu for various impact velocities and for single crystal copper [001] suggests two distinct stages of evolution of voids. The first stage (I) corresponds to the fast nucleation of voids followed by the second stage (II) attributed to growth and coalescence of voids. The first stage is found to be dependent on the microstructure of the system as well as the shock pressure/strain rate, whereas, the second stage of void growth is independent of the strain rate and microstructure of the system and dependent only on the number of voids nucleated. (C) 2010 American Institute of Physics. [doi:10.1063/1.3517827] C1 [Dongare, Avinash M.; Brenner, Donald W.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Dongare, Avinash M.; Zikry, Mohammed A.] N Carolina State Univ, Dept Mech & Aerosp Engn, Raleigh, NC 27695 USA. [Rajendran, Arunachalam M.] Univ Mississippi, Dept Mech Engn, University, MS 38677 USA. [LaMattina, Bruce] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Dongare, AM (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Engn Bldg 1,911 Partners Way,Campus Box 7907, Raleigh, NC 27695 USA. EM amdongare@ncsu.edu RI Brenner, Donald/D-1741-2009; Dongare, Avinash/A-3470-2009; OI Dongare, Avinash/0000-0003-3189-3588 FU U.S. Army Research Office (ARO) through the National Research Council; National Science Foundation [DMR-0304299, DMR-0806323] FX A.M.D. is supported by the U.S. Army Research Office (ARO) through the National Research Council Research Associateship Program. D.W.B. and M.A.Z. are also supported by the National Science Foundation through Grant Nos. DMR-0304299 and DMR-0806323. Any opinions, findings, and conclusions or recommendations expressed in this paper are those of the authors and do not necessarily reflect the views of the National Science Foundation or other funding agencies. NR 42 TC 22 Z9 24 U1 2 U2 28 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD DEC 1 PY 2010 VL 108 IS 11 AR 113518 DI 10.1063/1.3517827 PG 10 WC Physics, Applied SC Physics GA 696XG UT WOS:000285474100046 ER PT J AU Witzel, J AF Witzel, John TI At What Temperature Does Water Really Freeze? SO IEEE INSTRUMENTATION & MEASUREMENT MAGAZINE LA English DT Editorial Material C1 [Witzel, John] Paladin S, Kandahar, Afghanistan. [Witzel, John] USA, Washington, DC USA. RP Witzel, J (reprint author), Paladin S, Kandahar, Afghanistan. EM john.witzel@gmail.com NR 0 TC 0 Z9 0 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1094-6969 J9 IEEE INSTRU MEAS MAG JI IEEE Instrum. Meas. Mag. PD DEC PY 2010 VL 13 IS 6 BP 50 EP 53 DI 10.1109/MIM.2010.5669617 PG 4 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 697MU UT WOS:000285518500010 ER PT J AU Mancuso, J Keep, LW AF Mancuso, James Keep, Lisa W. TI Active Tuberculosis and Recent Overseas Deployment in the US Military Response SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Letter ID INFECTION C1 [Mancuso, James] Walter Reed Army Inst Res, Prevent Med Residency Program, Silver Spring, MD 20910 USA. [Keep, Lisa W.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. RP Mancuso, J (reprint author), Walter Reed Army Inst Res, Prevent Med Residency Program, 503 Robert Grant Rd, Silver Spring, MD 20910 USA. EM james.mancuso@us.army.mil NR 5 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD DEC PY 2010 VL 39 IS 6 BP E40 EP E40 DI 10.1016/j.amepre.2010.09.001 PG 1 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 680LT UT WOS:000284234100003 ER PT J AU Kaller, MD Hudson, JD AF Kaller, Michael D. Hudson, James D., III TI Phenological Partitioning among Drifting Insect Genera within Families in a Subtropical, Coastal Plain Stream (Louisiana, USA) SO JOURNAL OF FRESHWATER ECOLOGY LA English DT Article ID LOWER MISSISSIPPI RIVER; MACROINVERTEBRATE DRIFT; INVERTEBRATE DRIFT; PRINCIPAL COMPONENTS; TRANSPORT; PATTERNS AB We investigated invertebrate drift in a subtropical, coastal plain stream in Louisiana, USA. Once monthly, at a single site on Big Brushy Creek, eight three-hour drift samples (24 hours total) were collected using two 250-micron, 0.13-m(2) drift nets. We examined the data for seasonal trends in overall drift density by analysis of covariance and taxonomic composition by principal component analysis and multivariate analysis of covariance. We found no statistically significant seasonal differences in overall drift density, although community composition did statistically differ among months. More interestingly, we found that 26 genera (38%) exhibited asynchrony in peak drift timing within families. Although our study was limited in spatial scope, we suggest that these unusual results emphasize the need for additional invertebrate research in this region. C1 [Kaller, Michael D.] Louisiana State Univ, Ctr Agr, Sch Renewable Nat Resources, Baton Rouge, LA 70803 USA. [Hudson, James D., III] USA, Environm & Nat Resources Management Div, Ft Polk, LA 71459 USA. RP Kaller, MD (reprint author), Louisiana State Univ, Ctr Agr, Sch Renewable Nat Resources, Baton Rouge, LA 70803 USA. EM mkalle1@lsu.edu NR 41 TC 0 Z9 0 U1 0 U2 1 PU OIKOS PUBL INC PI LA CROSSE PA PO BOX 2558, LA CROSSE, WI 54601 USA SN 0270-5060 J9 J FRESHWATER ECOL JI J. Freshw. Ecol. PD DEC PY 2010 VL 25 IS 4 BP 607 EP 615 DI 10.1080/02705060.2010.9664410 PG 9 WC Ecology; Limnology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA 680OA UT WOS:000284243100013 ER PT J AU Zhang, W Emanetoglu, NW Bambha, N Bickford, JR AF Zhang, Wang Emanetoglu, Nuri W. Bambha, Neal Bickford, Justin R. TI Design and analysis of In0 53Ga0 47As/InP symmetric gain optoelectronic mixers SO SOLID-STATE ELECTRONICS LA English DT Article DE LADAR; Phototransistor; Optoelectronic mixer AB A symmetric gain optoelectronic mixer based on an indium gallium arsenide (In0 53Ga0 47As)/indium phosphide (InP) symmetric heterojunction phototransistor structure is being investigated for chirped-AM laser detection and ranging (LADAR) systems operating in the eye safe 1 55 mu m wavelength range Signal processing of a chirped-AM LADAR system is simplified if the photodetector in the receiver is used as an optoelectronic mixer (OEM) Adding gain to the OEM allows the following transimpedance amplifiers gain to be reduced increasing bandwidth and improving the system s noise performance A symmetric gain optoelectronic mixer based on a symmetric phototransistor structure using an indium gallium arsenide narrow bandgap base and indium phosphide emitter/collector layers is proposed The devices are simulated with the Synopsis TCAD Sentaurus tools The effects of base-emitter interface layers base thickness and the doping densities of the base and emitters on the device performance are investigated AC and DC simulation results are compared with a device model Improved responsivity and lower dark current are predicted for the optimized InGaAs/InP device over previously reported devices with indium aluminum arsenide emitter/collector layers (C) 2010 Elsevier Ltd All rights reserved C1 [Zhang, Wang; Emanetoglu, Nuri W.] Univ Maine, Orono, ME 04469 USA. [Bambha, Neal; Bickford, Justin R.] USA, Res Lab, Sensors & Electron Devices Directorate, Washington, DC USA. RP Emanetoglu, NW (reprint author), Univ Maine, Orono, ME 04469 USA. RI Emanetoglu, Nuri/D-5006-2013 NR 7 TC 0 Z9 0 U1 0 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-1101 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD DEC PY 2010 VL 54 IS 12 BP 1549 EP 1553 DI 10.1016/j.sse.2010.07.003 PG 5 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA 677GV UT WOS:000283978000011 ER PT J AU Hickman, SA Moore, EW Lee, S Longenecker, JG Wright, SJ Harrell, LE Marohn, JA AF Hickman, Steven A. Moore, Eric W. Lee, SangGap Longenecker, Jonilyn G. Wright, Sarah J. Harrell, Lee E. Marohn, John A. TI Batch-Fabrication of Cantilevered Magnets on Attonewton-Sensitivity Mechanical Oscillators for Scanned-Probe Nanoscale Magnetic Resonance Imaging SO ACS NANO LA English DT Article DE batch-fabricated cantilevers; magnetometry; electron-spin resonance; magnetic nanorods; magnetic resonance force microscopy; surface-induced dissipation ID FOCUSED-ION-BEAM; FORCE MICROSCOPY; ULTRASENSITIVE CANTILEVERS; RESOLUTION; TIPS; FLUCTUATIONS; LITHOGRAPHY; KINETICS; FILMS AB We have batch-fabricated cantilevers with similar to 100 nm diameter nickel nanorod tips and force sensitivities of a few attonewtons at 4.2 K. The magnetic nanorods were engineered to overhang the leading edge of the cantilever, and consequently the cantilevers experience what we believe is the lowest surface noise ever achieved in a scanned probe experiment. Cantilever magnetometry indicated that the tips were well magnetized, with a <= 20 nm dead layer; the composition of the dead layer was studied by electron microscopy and electron energy loss spectroscopy. In what we believe is the first demonstration of scanned probe detection of electron-spin resonance from a batch-fabricated tip, the cantilevers were used to observe electron-spin resonance from nitroxide spin labels in a film via force-gradient-induced shifts in cantilever resonance frequency. The magnetic field dependence of the magnetic resonance signal suggests a nonuniform tip magnetization at an applied field near 0.6 T. C1 [Hickman, Steven A.; Moore, Eric W.; Lee, SangGap; Longenecker, Jonilyn G.; Wright, Sarah J.; Marohn, John A.] Cornell Univ, Dept Chem & Chem Biol, Ithaca, NY 14853 USA. [Harrell, Lee E.] US Mil Acad, Dept Phys & Nucl Engn, West Point, NY 10996 USA. RP Marohn, JA (reprint author), Cornell Univ, Dept Chem & Chem Biol, Ithaca, NY 14853 USA. EM jam99@cornell.edu FU National Science Foundation [ECS-0335765]; National Science Foundation Materials Research Science and Engineering Centers (MRSEC) [DMR-0520404] FX This work was performed in part at the Cornell NanoScale Science and Technology Facility, a member of the National Nanotechnology Infrastructure Network, supported by the National Science Foundation (ECS-0335765). This work made use of the Transmission Electron Microscopy facility of the Cornell Center for Materials Research (CCMR) with support from the National Science Foundation Materials Research Science and Engineering Centers (MRSEC) program (DMR-0520404). We thank David Muller and especially Pinshane Huang for assistance with electron microscopy. JAM. acknowledges the National Science Foundation (DMR-0134956). E.W.M., S.-G. L, S.J.W., and JAM. acknowledge the National Institutes of Health (5R01GM-070012). S.A.H., J.G.L., L.E.H., and JAM. acknowledge the Army Research Office Multi-university Research Initiative (W911NF-05-1-0403). NR 50 TC 7 Z9 7 U1 1 U2 8 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1936-0851 J9 ACS NANO JI ACS Nano PD DEC PY 2010 VL 4 IS 12 BP 7141 EP 7150 DI 10.1021/nn101577t PG 10 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 696NW UT WOS:000285449100014 PM 21082863 ER PT J AU Kijak, GH Tovanabutra, S Beyrer, C Sanders-Buell, EE Arroyo, MA Robb, ML Michael, NL McCutchan, FE Kim, JH AF Kijak, Gustavo H. Tovanabutra, Sodsai Beyrer, Chris Sanders-Buell, Eric E. Arroyo, Miguel A. Robb, Merlin L. Michael, Nelson L. McCutchan, Francine E. Kim, Jerome H. TI RecDraw: A Software Package for the Representation of HIV-1 Recombinant Structures SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; IDENTIFICATION; BREAKPOINTS; THAILAND; STRAINS; FORMS AB The crucial role of recombination in HIV-1 biology is being increasingly recognized. In vitro studies have shown that up to 30 strand-transfer events may occur per viral replication cycle. Thus, recombination may surpass mutation as a major mechanism driving HIV-1 evolution. Currently, recombinant strains comprise 37% of the full-genome HIV-1 sequence database, including sequences representing 47 Circulating Recombinant Forms (CRFs) and more than 250 different Unique Recombinant Forms (URFs). Mapping of recombination breakpoints helps establish relationships among strains that are related by descent, such as CRF07_BC and CRF08_BC in China, and sheds light on their origin and epidemic spread. Additionally, unrelated recombinants sharing common breakpoints may reflect recombination hotspots within the viral genome. Here we present a software tool, RecDraw, for the graphical representation and efficient comparison of recombinant HIV-1 structures and breakpoints. RecDraw is a platform-flexible, Java stand-alone application available through http://www.hivresearch.org/research.php?ServiceID = 5&SubServiceID = 6. C1 [Kijak, Gustavo H.; Tovanabutra, Sodsai; Sanders-Buell, Eric E.; Robb, Merlin L.; McCutchan, Francine E.] US Mil HIV Res Program, Henry M Jackson Fdn Advancement Mil Med, Rockville, MD 20850 USA. [Beyrer, Chris] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. [Arroyo, Miguel A.; Michael, Nelson L.; Kim, Jerome H.] Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD USA. RP Kijak, GH (reprint author), US Mil HIV Res Program, Henry M Jackson Fdn Advancement Mil Med, 1600 E Gude Dr, Rockville, MD 20850 USA. EM gkijak@hivresearch.org OI Arroyo, Miguel/0000-0001-7416-8867 FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DOD) [W81XWH-07-2-0067]; National Institute for Allergy and Infectious Diseases, National Institutes of Health [YD1 AI2642-12] FX This work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD), and by the National Institute for Allergy and Infectious Diseases, National Institutes of Health (YD1 AI2642-12, NIAID/MRMC HIV/AIDS Vaccine Research and Development Program). The views and opinions expressed herein do not necessarily reflect those of the U.S. Army, the Department of Defense, or the National Institutes of Health. NR 20 TC 2 Z9 2 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD DEC PY 2010 VL 26 IS 12 BP 1317 EP 1321 DI 10.1089/aid.2010.0127 PG 5 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 692YP UT WOS:000285192100011 PM 20961275 ER PT J AU Johnson, KJ Peck, AR Liu, CB Tran, TH Utama, FE Sjolund, AB Schaber, JD Witkiewicz, AK Rui, H AF Johnson, Kevin J. Peck, Amy R. Liu, Chengbao Tran, Thai H. Utama, Fransiscus E. Sjolund, Ashley B. Schaber, John D. Witkiewicz, Agnieszka K. Rui, Hallgeir TI PTP1B Suppresses Prolactin Activation of Stat5 in Breast Cancer Cells SO AMERICAN JOURNAL OF PATHOLOGY LA English DT Article ID PROTEIN-TYROSINE-PHOSPHATASE; MAMMARY EPITHELIAL-CELLS; JAK/STAT SIGNALING COMPONENTS; TRANSCRIPTION FACTORS; MYELOID-LEUKEMIA; OVARIAN-CANCER; TRANSDUCER; EXPRESSION; 1B; RECEPTOR AB Basal levels of nuclear localized tyrosine phosphorylated Stat5 are present in healthy human breast epithelia In contrast Stat5 phosphorylation is frequently lost during breast cancer progression a finding that correlates with loss of histological differentiation and poor patient prognosis Identifying the mechanisms underlying loss of Stat5 phosphorylation could provide novel targets for breast cancer therapy Pervanadate a general tyrosine phosphatase Inhibitor revealed marked phosphatase regulation of Stat5 activity in breast cancer cells Lentiviral mediated shRNA allowed specific examination of the regulatory role of five tyrosine phosphatases (PTP1B TC PTP SHP1 SHP2 and VHR) previously implicated in Stat5 regulation in various systems Enhanced and sustained prolactin induced Stat5 tyrosine phosphorylation was observed in T47D and MCF7 breast cancer cells selectively in response to PTP1B depletion Conversely PTP1B overexpression suppressed prolactin induced Stat5 tyrosine phosphorylation Furthermore PTP1B knockdown increased Stat5 reporter gene activity Mechanistically PTP1B suppression of Stat5 phosphorylation was mediated at least m part through inhibitory dephosphorylation of the Stat5 tyrosine kinase Jak2 PTP1B knockdown enhanced sensitivity of T47D cells to prolactin phosphorylation of Stat5 by reducing the EC(50) from 72 nmol/L to 25 nmol/L. Immunohistochemical analyses of two in dependent clinical breast cancer materials revealed significant negative correlations between levels of active Stat5 and PTP1B but not TC PIP Collectively our data Implicate PTP1B as an important negative regulator of Stat5 phosphorylation in invasive breast cancer (Am J Pathol 2010 177 2971-2983; DOI 10.2353/ajpath 2010 090399) C1 [Rui, Hallgeir] Thomas Jefferson Univ, Dept Canc Biol, Dept Med Oncol, Kimmel Canc Ctr, Philadelphia, PA 19107 USA. [Johnson, Kevin J.] Georgetown Univ, Lombardi Comprehens Canc Ctr, Dept Oncol, Washington, DC USA. [Schaber, John D.] Womack Army Med Ctr, Dept Res, Ft Bragg, NC USA. [Witkiewicz, Agnieszka K.] Thomas Jefferson Univ, Dept Pathol, Philadelphia, PA 19107 USA. [Rui, Hallgeir] Thomas Jefferson Univ, Jefferson Breast Care Ctr, Philadelphia, PA 19107 USA. RP Rui, H (reprint author), Thomas Jefferson Univ, Dept Canc Biol, Dept Med Oncol, Kimmel Canc Ctr, 233 S 10th St,BLSB 330, Philadelphia, PA 19107 USA. FU National Institutes of Health [R01 CA101841, R01 CA118740]; National Cancer Institute [1P30CA56036]; Commonwealth University; Pennsylvania Department of Health FX Supported by National Institutes of Health grants R01 CA101841 and R01 CA118740 (H R) and National Cancer Institute support grant 1P30CA56036 to the Kimmel Cancer Center This project is funded in part under a Commonwealth University Research Enhancement program grant with the Pennsylvania Department of Health (H R) NR 71 TC 27 Z9 28 U1 0 U2 6 PU AMER SOC INVESTIGATIVE PATHOLOGY, INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3993 USA SN 0002-9440 J9 AM J PATHOL JI Am. J. Pathol. PD DEC PY 2010 VL 177 IS 6 BP 2971 EP 2983 DI 10.2353/ajpath.2010.090399 PG 13 WC Pathology SC Pathology GA 695KU UT WOS:000285369800030 PM 20952588 ER PT J AU Merlo, JL Duley, AR Hancock, PA AF Merlo, James L. Duley, Aaron R. Hancock, Peter A. TI Cross-modal congruency benefits for combined tactile and visual signaling SO AMERICAN JOURNAL OF PSYCHOLOGY LA English DT Article ID MULTISENSORY INTEGRATION; SUPERIOR COLLICULUS; MOTION PERCEPTION; INFORMATION; MODEL; CAT; ATTENTION; NEURONS; VISION; TOUCH AB This series of experiments tested the assimilation and efficacy of tactile messages that were created based on five common military arm and hand signals. We compared the response times and accuracy rates for these tactile representations against responses to equivalent visual representations of the same messages. Experimentally, such messages were displayed in either tactile or visual forms alone, or using both modalities in combination. There was a performance benefit for concurrent message presentations, which showed superior response times and improved accuracy rates when compared with individual presentations in either modality alone. Such improvement was due largely to a reduction in premotor response time. These improvements occurred equally in military and nonmilitary samples. Potential reasons for this multimodal facilitation are discussed. On a practical level, these results confirm the utility of tactile messaging to augment visual messaging, especially in challenging and stressful environments where visual messaging is not feasible or effective. C1 [Merlo, James L.] US Mil Acad, West Point, NY 10996 USA. [Duley, Aaron R.] NASA, Ames Res Ctr, Washington, DC 20546 USA. [Hancock, Peter A.] Univ Cent Florida, Orlando, FL 32816 USA. RP Merlo, JL (reprint author), US Mil Acad, West Point, NY 10996 USA. EM james.merlo@usma.edu NR 36 TC 5 Z9 5 U1 0 U2 3 PU UNIV ILLINOIS PRESS PI CHAMPAIGN PA 1325 S OAK ST, CHAMPAIGN, IL 61820-6903 USA SN 0002-9556 J9 AM J PSYCHOL JI Am. J. Psychol. PD WIN PY 2010 VL 123 IS 4 BP 413 EP 424 PG 12 WC Psychology, Multidisciplinary SC Psychology GA 699UI UT WOS:000285688000004 PM 21291158 ER PT J AU Eastridge, BJ Butler, F Wade, CE Holcomb, JB Salinas, J Champion, HR Blackbourne, LH AF Eastridge, Brian J. Butler, Frank Wade, Charles E. Holcomb, John B. Salinas, Jose Champion, Howard R. Blackbourne, Lorne H. TI Field triage score (FTS) in battlefield casualties: validation of a novel triage technique in a combat environment SO AMERICAN JOURNAL OF SURGERY LA English DT Article DE Military; War; Combat; Injury; Trauma; Triage ID MAJOR TRAUMA VICTIMS; RULE; SEVERITY; JUDGMENT; CRITERIA; CARE AB BACKGROUND: By the principles of Tactical Combat Casualty Care, battlefield casualties are preferentially triaged on the basis of pulse character and mental status. A weak or absent palpable pulse correlates with a systolic blood pressure (SBP) of <= 100 mm Hg. Furthermore, the motor component of the Glasgow Coma Scale (GCS-M) has been shown to correlate with outcomes. In a previous study, the authors developed a simple triage tool, the field triage score (FTS), on the basis of pulse character and GCS-M status, which provided a quick and effective means of predicting injury survival in the civilian trauma environment. The purpose of this analysis was to validate the predictive utility of the FTS in the battlefield trauma environment. METHODS: The Joint Theater Trauma Registry was used to identify 4,988 battlefield casualties from Iraq and Afghanistan from January 2002 to September 2008 with requisite admission data elements of SBP, GCS-M status, and survival. SBP was stratified as <= 100 mm Hg, consistent with weak or absent pulse character, or >100 mm Hg, consistent with a normal pulse character. GCS-M status was stratified as either abnormal (<6) or normal (6). Casualties with presenting SBPs of 0 mm Hg were excluded from the analysis. As in the civilian trauma triage study, the FTS was derived by assigning a component value of 0 for weak or absent pulse or abnormal GCS-M status and a component value of 1 for either a normal pulse or normal GCS-M status. Adding the scores resulted in an aggregate FTS value of 0, 1, or 2. RESULTS: For the overall population of 4,988 casualties, 87.5% (n = 4,366) had FTS of 2, with overall mortality of .1% (5 of 4,366). From the battlefield, 10.8% of patients (n = 540) presenting with FT'S of 1 had a mortality rate that increased to 6.1% (33 of 540). In contrast, combat casualties presenting with FTS of 0 had a significantly higher mortality of 41.4% (34 of 82). The calculated lengths of stay were 6.1 (FTS 2), 9.2 (FTS 1), and 17.7 (FTS 0) days. CONCLUSION: This study has validated the utility of the FTS as a simple and practical triage instrument for use in the battlefield environment. Using the FTS, medics and medical providers will have a quick and effective measure to predict high-acuity combat casualties to triage evacuation and medical resources in austere military environments. This technique may have potential implications for domestic or foreign disaster or mass casualty situations in which supplies, medical resources, and facilities are limited. Published by Elsevier Inc. C1 [Eastridge, Brian J.; Butler, Frank; Wade, Charles E.; Salinas, Jose; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Holcomb, John B.] Univ Texas Houston, Houston, TX USA. [Champion, Howard R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Eastridge, BJ (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM brian.eastridge@amedd.army.mil NR 26 TC 13 Z9 13 U1 0 U2 1 PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC PI BRIDGEWATER PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA SN 0002-9610 J9 AM J SURG JI Am. J. Surg. PD DEC PY 2010 VL 200 IS 6 BP 724 EP 727 DI 10.1016/j.amjsurg.2010.08.006 PG 4 WC Surgery SC Surgery GA 708EO UT WOS:000286344900016 PM 21146011 ER PT J AU Corneille, MG Villa, C Wolf, S Michalek, JE Jung, IK Wade, CE Myers, JG Dent, DL Mueller, D Stewart, RM AF Corneille, Michael G. Villa, Celina Wolf, Steven Michalek, Joel E. Jung, Inkyung Wade, Charles E. Myers, John G. Dent, Daniel L. Mueller, Deborah Stewart, Ronald M. TI Time and degree of glycemic derangement are associated with increased modality in trauma patients in the setting of tight glycemic control SO AMERICAN JOURNAL OF SURGERY LA English DT Article DE Glucose; Glycemic control; Hyperglycemia; Trauma; Hypoglycemia; Critically ill ID CRITICALLY-ILL PATIENTS; ACUTE MYOCARDIAL-INFARCTION; INSULIN INFUSION PROTOCOL; CARDIAC-SURGERY PATIENTS; BLOOD-GLUCOSE CONTROL; INTENSIVE-CARE-UNIT; ADMISSION HYPERGLYCEMIA; INCREASED MORTALITY; SHORT-TERM; THERAPY AB BACKGROUND: Tight glucose control (TGC) may reduce mortality in critically ill trauma patients. We hypothesize that euglycemia is beneficial, and a measure considering time and degree of hyperglycemia is most associated with mortality. METHODS: We performed a review of intensive care unit trauma patients admitted for more than 3 days between January 2005 and December 2007 on a TGC protocol with a goal of 80 to 110 mg/dL. Hyperglycemic, hypoglycemic, and euglycemic time ranges, and area of interpolated curves above and below 80 to 110 mg/dL were assessed. Associations with mortality were based on logistic regression models adjusted for age, injury severity score, and admission Glasgow Coma Scale score. RESULTS: A total of 546 patients were identified, and 68(13%) died. Time spent as hyperglycemic (P = .29) and hyperglycemic area under the curve (P = .58) were not associated with mortality; hyperglycemic area/time (P = .01) was associated with mortality. Regarding hypoglycemia, area over the curve (P = .009) and time spent as hypoglycemic (P = .002) were associated with mortality. CONCLUSIONS: TGC prevents prolonged, high degrees of hyperglycemia; avoiding hypoglycemia likely provides mortality benefit for trauma patients. (C) 2010 Elsevier Inc. All rights reserved. C1 [Corneille, Michael G.; Villa, Celina; Wolf, Steven; Myers, John G.; Dent, Daniel L.; Mueller, Deborah; Stewart, Ronald M.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA. [Michalek, Joel E.; Jung, Inkyung] Univ Texas Hlth Sci Ctr San Antonio, Dept Epidemiol & Biostat, San Antonio, TX 78229 USA. [Wade, Charles E.] USA, Inst Surg Res, Med Res & Mat Command, Ft Sam Houston, TX 78234 USA. RP Corneille, MG (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA. EM Corneille@uthscsa.edu FU Department of the Army [W81XWH-07-1-0717] FX This study was sponsored by the Department of the Army, award number W81XWH-07-1-0717. NR 38 TC 2 Z9 2 U1 0 U2 0 PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC PI BRIDGEWATER PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA SN 0002-9610 J9 AM J SURG JI Am. J. Surg. PD DEC PY 2010 VL 200 IS 6 BP 832 EP 837 DI 10.1016/j.amjsurg.2010.07.034 PG 6 WC Surgery SC Surgery GA 708EO UT WOS:000286344900052 PM 21146029 ER PT J AU Cohn, SM Pearl, RG Acosta, SM Nowlin, MU Hernandez, A Guta, C Michalek, JE AF Cohn, Stephen M. Pearl, Ronald G. Acosta, Shirley M. Nowlin, Marilyn U. Hernandez, Antonio Guta, Cosmin Michalek, Joel E. CA NIRF Clinical Trials Grp TI A Prospective Randomized Pilot Study of Near-Infrared Spectroscopy-Directed Restricted Fluid Therapy versus Standard Fluid Therapy in Patients Undergoing Elective Colorectal Surgery SO AMERICAN SURGEON LA English DT Article ID HEMORRHAGIC-SHOCK; OXYGEN-SATURATION; CONTROLLED-TRIAL; RESUSCITATION; DYSFUNCTION; MANAGEMENT; PERFUSION; RESECTION; RECOVERY; TRAUMA AB There are substantial data supporting the concept that algorithms that effectively limit fluid volumes to patients undergoing elective surgery, particularly intraoperatively, significantly reduce perioperative morbidity. We hypothesized that intraoperative fluid limitation could be safely accomplished when guided by near-infrared spectroscopy (NIRS) monitoring, and that this fluid restriction regimen would result in a reduction in postoperative morbidity when compared with standard monitoring and fluid therapy. The intent of this pilot study was to demonstrate the feasibility and ease of conduct of this study protocol before expanding to the multicenter pivotal trial. We performed a prospective, (2:1) randomized, pilot study at two centers. A total enrollment of 24 fully evaluable patients undergoing elective open colorectal surgery (16 restricted, 8 standard) was planned. After providing informed consent, patients were randomized to standard fluid resuscitation (500 LR induction bolus, then LR 7 mL/kg/h x 1 h, then 5 mL/kg/h) or restricted fluid resuscitation (no induction bolus, then LR 2 mL/kg/h). Subsequent fluid bolus infusions were guided by physiologic parameters (systolic blood pressure < 90 mm Hg, heart rate > 100 bpm, or oliguria) in the standard group, and by tissue oxygen saturation from NIRS (tissue oxygen saturation (StO(2)) < 75%, or 20% below baseline; or the same physiologic parameters) in the restricted group. Primary endpoints were major postoperative complications. A total of 27 patients were randomized (18 restricted, 9 standard). Age, gender, ethnicity, past medical history, and body mass index were similar. American Society of Anesthesiologists class was somewhat higher in the restricted group (American Society of Anesthesiologists class 3 in 77% of restricted vs 44% of standard patients; P = 0.194). Median total intraoperative fluids were less in the restricted group (1300 mL) when compared with the standard group (3014 mL) (P = 0.021). Total fluids for the hospitalization were also statistically significantly decreased in the restricted group. Complications occurred in about two-thirds of patients, and complication rates were not statistically different between groups (1.6/restricted patient vs 2.1/standard patient; P = 0.333). Primary indications for boluses (n = 93) given to study patients were: hypotension (69%); oliguria (15%); and tachycardia (14%), with multiple indications per bolus. In only two instances did the StO(2) drop to less than 75 per cent, or decrease by 20 per cent from baseline in the 3 minutes before bolus as an indication for fluid administration. Patients undergoing elective colorectal surgery with a fluid restricted strategy had only rare episodes of decreased StO(2), suggesting that adequate tissue perfusion was maintained in this group. As a result, NIRS monitoring did not significantly influence intraoperative fluid management of patients undergoing colorectal surgery. C1 [Cohn, Stephen M.; Acosta, Shirley M.; Hernandez, Antonio; Michalek, Joel E.] Univ Texas San Antonio, Hlth Sci Ctr, Dept Surg, San Antonio, TX 78229 USA. [Pearl, Ronald G.; Guta, Cosmin] Stanford Univ, Stanford, CA 94305 USA. [Nowlin, Marilyn U.] Brooke Army Med Ctr, San Antonio, TX USA. RP Cohn, SM (reprint author), Univ Texas San Antonio, Hlth Sci Ctr, Dept Surg, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA. EM cohn@uthscsa.edu FU Hutchinson Technology Incorporated, Hutchinson, MN FX This study was sponsored by a grant from Hutchinson Technology Incorporated, Hutchinson, MN. The authors wish to thank the University Hospital, San Antonio and the Stanford University Hospital Operating Room nursing and resident staff for their support. NR 27 TC 11 Z9 11 U1 0 U2 1 PU SOUTHEASTERN SURGICAL CONGRESS PI ATLANTA PA 141 WEST WIEUCA RD, STE B100, ATLANTA, GA 30342 USA SN 0003-1348 J9 AM SURGEON JI Am. Surg. PD DEC PY 2010 VL 76 IS 12 BP 1384 EP 1392 PG 9 WC Surgery SC Surgery GA 697CD UT WOS:000285489300012 PM 21265353 ER PT J AU Woodka, MD Schnee, VP Polcha, MP AF Woodka, Marc D. Schnee, Vincent P. Polcha, Michael P. TI Fluorescent Polymer Sensor Array for Detection and Discrimination of Explosives in Water SO ANALYTICAL CHEMISTRY LA English DT Article ID CHEMIRESISTOR SENSOR; ANALYTE MIXTURES; CHEMICAL SENSORS; ELECTRONIC NOSE; FILMS; MICROCANTILEVERS; SPECTROSCOPY; SYSTEMS; VAPORS; DESIGN AB A fluorescent polymer sensor array (FPSA) was made from commercially available fluorescent polymers coated onto glass beads and was tested to assess the ability of the array to discriminate between different analytes in aqueous solution The array was challenged with exposures to 17 different analytes, including the explosives trinitrotoluene (TNT), tetryl, and RDX, various explosive related compounds (ERCs), and nonexplosive electron withdrawing compounds (EWCs) The array exhibited a natural selectivity toward EWCs, while the non-electron withdrawing explosive 1,3,5-trinitroperhydro-1,3,5-triazine (RDX) produced no response Response signatures were visualized by principal component analysis (PCA), and classified by linear discriminant analysis (LDA) RDX produced the same response signature as the sampled blanks and was classified accordingly The array exhibited excellent discrimination toward all other compounds, with the exception of the isomers of nitrotoluene and amino dinitrotoluene Of particular note was the ability of the array to discriminate between the three isomers of dinitrobenzene The natural selectivity of the FPSA toward EWCs, plus the ability of the FPSA to discriminate between different EWCs, could be used to design a sensor with a low false alarm rate and an excellent ability to discriminate between explosives and explosive related compounds C1 [Woodka, Marc D.; Schnee, Vincent P.] USA, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA 22060 USA. [Polcha, Michael P.] Corbin Co, Alexandria, VA 22314 USA. RP Woodka, MD (reprint author), USA, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA 22060 USA. FU Department of Defense Unexploded Ordnance Center of Excellence (DoD UXOCOE) FX The authors thank the Department of Defense Unexploded Ordnance Center of Excellence (DoD UXOCOE) for financial support The National Research Council is acknowledged for a postdoctoral fellowship to V P S NR 47 TC 25 Z9 26 U1 3 U2 43 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD DEC 1 PY 2010 VL 82 IS 23 BP 9917 EP 9924 DI 10.1021/ac102504t PG 8 WC Chemistry, Analytical SC Chemistry GA 686AG UT WOS:000284668600047 PM 21069967 ER PT J AU Wilson, ALG Hoge, CW McGurk, D Thomas, JL Clark, JC Castro, CA AF Wilson, Abigail L. Garvey Hoge, Charles W. McGurk, Dennis Thomas, Jeffrey L. Clark, Julie C. Castro, Carl A. TI Application of a New Method for Linking Anonymous Survey Data in a Population of Soldiers Returning from Iraq SO ANNALS OF EPIDEMIOLOGY LA English DT Article DE Data Linkage; Operation Iraqi Freedom; Post-Traumatic Stress Disorder; Survey Methodology; Validation Studies ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; PERSIAN-GULF-WAR; TRAUMATIC EVENTS; RECORD LINKAGE; NAVY RECRUITS; PTSD; CONSISTENCY; CHECKLIST; VETERANS AB PURPOSE: This study provides a unique application of a procedure to link anonymous survey records as a means to assess mental health problems among soldiers after return from deployment to Iraq. The research purpose is to validate the use of a linkage method on anonymous survey data for longitudinal analysis. METHODS: This research analyzes surveys completed by soldiers at three (N = 4,903), six (N = 3,110), and 12 (N = 2,544) months post Operation Iraqi Freedom (OIF) deployment. To protect anonymity while also allowing for longitudinal analysis, the survey includes four self-generated codes for matching the surveys from individual soldiers. The surveys were linked using Link Plus (Centers for Disease Control and Prevention, Atlanta, GA). Three matched groups (3-6 months, 6-12 months, and 3-12 months) were created, matching on the anonymous codes and demographic variables. An internal validation of the linkage results was performed and selection bias was assessed. RESULTS: The matched records showed very high agreement in variables not included in the matching procedure and were similar to the unmatched records with regard to demographics and post-traumatic stress disorder (PTSD) prevalence. CONCLUSIONS: The use of self-generated codes protects anonymity while the method utilized and validated in this paper allows for longitudinal data analysis. The results support an absence of any notable selection bias. Ann Epidemiol 2010;20:931-938. 2010 (C) Elsevier Inc. All rights reserved. C1 [Wilson, Abigail L. Garvey] George Washington Univ, Washington, DC 20052 USA. [Hoge, Charles W.; McGurk, Dennis; Thomas, Jeffrey L.; Clark, Julie C.; Castro, Carl A.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Wilson, ALG (reprint author), George Washington Univ, Washington, DC 20052 USA. EM abigail.wilson@gmail.com NR 32 TC 5 Z9 5 U1 2 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1047-2797 J9 ANN EPIDEMIOL JI Ann. Epidemiol. PD DEC PY 2010 VL 20 IS 12 BP 931 EP 938 DI 10.1016/j.annepidem.2010.08.008 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 686AK UT WOS:000284669000008 ER PT J AU Wilson, ALG Hoge, CW McGurk, D Thomas, JL Castro, CA AF Wilson, Abigail L. Garvey Hoge, Charles W. McGurk, Dennis Thomas, Jeffrey L. Castro, Carl A. TI Stability of Combat Exposure Recall in Operation Iraqi Freedom Veterans SO ANNALS OF EPIDEMIOLOGY LA English DT Article DE Longitudinal Study; Mental Recall; Operation Iraqi Freedom; Post-Traumatic Stress Disorder; Surveys ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; PERSIAN-GULF-WAR; TRAUMATIC EVENTS; MILITARY SERVICE; PTSD CHECKLIST; NAVY RECRUITS; CONSISTENCY; POPULATION; METAANALYSIS AB PURPOSE: This study evaluates changes in recall of combat exposures over the first year after return from deployment. The research purpose is to assess whether recall of combat exposures is consistent at different time points; if not, what demographic and/or PTSD symptom risk factors exist for any directional instability. METHODS: Surveys completed by soldiers at 3, 6, and 12 months post Operation Iraqi Freedom (OIF) deployment were linked for longitudinal analysis in a previous study in which three matched datasets were created: 3-6 months (N = 768), 6-12 months (N = 341), and 3-12 months (N = 445). Post-traumatic stress disorder (PTSD) was assessed by using the National Center for PTSD Checklist. The reliability of recall for 36 combat exposures was quantified. The effects of demographics and change in PTSD score on combat exposure recall were assessed. RESULTS: The results showed an average of 80% to 90% agreement in combat exposure reporting between the time points. Every one-unit change in PTSD score was associated with a 0.1- to 0.5-unit change in recall of combat exposures over time. CONCLUSIONS: This study demonstrates that over the first year after return from deployment to Iraq, recall of combat experiences remained stable, and PTSD was slightly associated with increased reporting of combat exposures over time. Ann Epidemiol 2010;20:939-947. (C) 2010 Elsevier Inc. All rights reserved. C1 [Wilson, Abigail L. Garvey] George Washington Univ, Washington, DC 20052 USA. [Hoge, Charles W.; McGurk, Dennis; Thomas, Jeffrey L.; Castro, Carl A.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Wilson, ALG (reprint author), George Washington Univ, Washington, DC 20052 USA. EM abigail.wilson@gmail.com NR 32 TC 4 Z9 4 U1 2 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1047-2797 J9 ANN EPIDEMIOL JI Ann. Epidemiol. PD DEC PY 2010 VL 20 IS 12 BP 939 EP 947 DI 10.1016/j.annepidem.2010.08.007 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 686AK UT WOS:000284669000009 ER PT J AU Gundi, VAKB Kosoy, MY Myint, KSA Shrestha, SK Shrestha, MP Pavlin, JA Gibbons, RV AF Gundi, Vijay A. K. B. Kosoy, Michael Y. Myint, Khin S. A. Shrestha, Sanjaya K. Shrestha, Mrigendra P. Pavlin, Julie A. Gibbons, Robert V. TI Prevalence and Genetic Diversity of Bartonella Species Detected in Different Tissues of Small Mammals in Nepal SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID MOLECULAR-DETECTION; RATTUS-NORVEGICUS; SOUTHERN CHINA; SP-NOV; RODENTS; INFECTION; IDENTIFICATION; THAILAND; STRAINS; SPP. AB Bartonellae were detected in a total of 152 (23.7%) of 642 tissues from 108 (48.4%) of 223 small mammals trapped in several urban areas of Nepal. Based on rpoB and gltA sequence analyses, genotypes belonging to seven known Bartonella species and five genotypes not belonging to previously known species were identified in these animals. C1 [Gundi, Vijay A. K. B.; Kosoy, Michael Y.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80521 USA. [Myint, Khin S. A.; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Dept Virol, US Army Med Component, Bangkok 10400, Thailand. [Shrestha, Sanjaya K.; Shrestha, Mrigendra P.] Walter Reed Armed Forces Res Inst, Med Sci Res Unit Nepal, Kathmandu, Nepal. [Pavlin, Julie A.] Armed Forces Res Inst Med Sci, Dept Global Emerging Infect, US Army Med Component, Bangkok 10400, Thailand. RP Kosoy, MY (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, 3150 Rampart Rd,Foothills Res Campus, Ft Collins, CO 80521 USA. EM MKosoy@cdc.gov RI Valle, Ruben/A-7512-2013 FU Emerging Infectious Diseases (EID); Centers for Disease and Control and Prevention (CDC) FX This research was supported in part by the appointment of Vijay A. K. B. Gundi to the Emerging Infectious Diseases (EID) Fellowship Program, administered by the Association of Public Health Laboratories (APHL) and funded by the Centers for Disease and Control and Prevention (CDC). NR 28 TC 11 Z9 12 U1 0 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD DEC PY 2010 VL 76 IS 24 BP 8247 EP 8254 DI 10.1128/AEM.01180-10 PG 8 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 688VO UT WOS:000284882800043 PM 21037303 ER PT J AU Zatzick, DF Rivara, FP Jurkovich, GJ Hoge, CW Wang, J Fan, MY Russo, J Trusz, SG Nathens, A Mackenzie, EJ AF Zatzick, Douglas F. Rivara, Frederick P. Jurkovich, Gregory J. Hoge, Charles W. Wang, Jin Fan, Ming-Yu Russo, Joan Trusz, Sarah Geiss Nathens, Avery Mackenzie, Ellen J. TI Multisite Investigation of Traumatic Brain Injuries, Posttraumatic Stress Disorder, and Self-reported Health and Cognitive Impairments SO ARCHIVES OF GENERAL PSYCHIATRY LA English DT Article ID QUALITY-OF-LIFE; MOTOR-VEHICLE ACCIDENTS; SPINAL-CORD-INJURY; FUNCTIONAL OUTCOMES; NEUROPSYCHOLOGICAL OUTCOMES; PSYCHOMETRIC PROPERTIES; PTSD CHECKLIST; FOLLOW-UP; IRAQ-WAR; SYMPTOMS AB Context: Few large-scale, multisite investigations have assessed the development of posttraumatic stress disorder (PTSD) symptoms and health outcomes across the spectrum of patients with mild, moderate, and severe traumatic brain injury (TBI). Objectives: To understand the risk of developing PTSD symptoms and to assess the impact of PTSD on the development of health and cognitive impairments across the full spectrum of TBI severity. Design: Multisite US prospective cohort study. Setting: Eighteen level I trauma centers and 51 non-trauma center hospitals. Patients: A total of 3047 (weighted n=10 372) survivors of multiple traumatic injuries between the ages of 18 and 84 years. Main Outcome Measures: Severity of TBI was categorized from chart-abstracted International Classification of Diseases, Ninth Revision, Clinical Modification codes. Symptoms consistent with a DSM-IV diagnosis of PTSD were assessed with the PTSD Checklist 12 months after injury. Self-reported outcome assessment included the 8 Medical Outcomes Study 36-Item Short Form Health Survey health status domains and a 4-item assessment of cognitive function at telephone interviews 3 and 12 months after injury. Results: At the time of injury hospitalization, 20.5% of patients had severe TBI, 11.7% moderate TBI, 12.9% mild TBI, and 54.9% no TBI. Patients with severe (relative risk, 0.72; 95% confidence interval, 0.58-0.90) and moderate (0.63; 0.44-0.89) TBI, but not mild TBI (0.83; 0.61-1.13), demonstrated a significantly diminished risk of PTSD symptoms relative to patients without TBI. Across TBI categories, in adjusted analyses patients with PTSD demonstrated an increased risk of health status and cognitive impairments when compared with patients without PTSD. Conclusions: More severe TBI was associated with a diminished risk of PTSD. Regardless of TBI severity, injured patients with PTSD demonstrated the greatest impairments in self-reported health and cognitive function. Treatment programs for patients with the full spectrum of TBI severity should integrate intervention approaches targeting PTSD. C1 [Zatzick, Douglas F.] Univ Washington, Sch Med, Dept Psychiat & Behav Sci, Harborview Injury Prevent & Res Ctr, Seattle, WA 98104 USA. [Hoge, Charles W.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Nathens, Avery] Univ Toronto, Dept Surg, Toronto, ON, Canada. [Mackenzie, Ellen J.] Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Injury Res & Policy, Baltimore, MD USA. RP Zatzick, DF (reprint author), Univ Washington, Sch Med, Dept Psychiat & Behav Sci, Harborview Injury Prevent & Res Ctr, Campus Box 359911,325 9th Ave, Seattle, WA 98104 USA. EM dzatzick@u.washington.edu FU National Center for Injury Prevention and Control [R49/CCR316840]; National Institute on Aging [R01/AG20361]; National Institute of Mental Health [R01/MH073613, K24/MH086814]; Centers for Disease Control and Prevention FX This work was funded by grant R49/CCR316840 from the National Center for Injury Prevention and Control and the Centers for Disease Control and Prevention, grant R01/AG20361 from the National Institute on Aging, and grants R01/MH073613 and K24/MH086814 from the National Institute of Mental Health. NR 102 TC 42 Z9 42 U1 5 U2 10 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0003-990X J9 ARCH GEN PSYCHIAT JI Arch. Gen. Psychiatry PD DEC PY 2010 VL 67 IS 12 BP 1291 EP 1300 DI 10.1001/archgenpsychiatry.2010.158 PG 10 WC Psychiatry SC Psychiatry GA 690NO UT WOS:000285011700013 PM 21135329 ER PT J AU Raybon, G Winzer, PJ Song, H Adamiecki, A Corteselli, S Gnauck, AH Kissell, T Fishman, DA Denkin, NM Kao, YH Downs, TL Carenza, A Scrudato, S Goode, EH Thompson, WA Doerr, CR Buhl, LL Xia, TJ Wellbrock, G Lee, W Lyons, G Hofmann, P Fisk, TT Basch, EB Kluge, WJ Gatewood, JR Kawanishi, T Higuma, K Painchaud, Y AF Raybon, Gregory Winzer, Peter J. Song, Haoyu Adamiecki, Andrew Corteselli, Stephen Gnauck, Alan H. Kissell, Thomas Fishman, Daniel A. Denkin, Nat M. Kao, Yuan-Hua Downs, Terry L. Carenza, Anthony Scrudato, Stephan Goode, Edward H. Thompson, William A. Doerr, Christopher R. Buhl, Lawrence L. Xia, Tiejun Wellbrock, Glenn Lee, Wang Lyons, Greg Hofmann, Peter Fisk, Tina T. Basch, E. Bert Kluge, William J. Gatewood, Johnny R. Kawanishi, Tetsuya Higuma, Kaoru Painchaud, Yves TI 100 Gb/s DQPSK Field Trial: Live Video Transmission Over an Operating LambdaXtreme (R) Network SO BELL LABS TECHNICAL JOURNAL LA English DT Article ID OPTICAL SIGNAL GENERATION; SYSTEMS AB Successful transmission of live (real time) video traffic is demonstrated using a prototype 100 Gb/s single-polarization differential quadrature phase shift keying (DQPSK) transmitter and receiver over an in-service 504 km link of the LambdaXtreme (R) optical transport platform. Teaming with Verizon Business, we demonstrate the feasibility of upgrading an existing, live traffic bearing network to 100 Gb/s per wavelength without any changes to the current hardware or software. The 107Gb/s signal is added at a reconfigurable optical add/drop multiplexer (ROADM) at a network node in Tampa, Florida, and dropped at a ROADM in Miami, Florida, where both live video and pseudorandom test sequences are received. In addition, we discuss the steps leading up to this field trial that included several important precursor laboratory experiments. We detail the generation, detection, coding, and long-haul transmission of single-polarization DQPSK at a line rate of 53.5 Gbaud to support a net information bit rate of 100 Gb/s. (C) 2010 Alcatel-Lucent. C1 [Raybon, Gregory] Natl Semicond Corp, Santa Clara, CA USA. [Raybon, Gregory] AT&T Bell Labs, Photon Networks Res Dept, Murray Hill, NJ USA. [Song, Haoyu] Alcatel Lucent Bell Labs, Networking & Networks Res Domain, Holmdel, NJ USA. [Adamiecki, Andrew] Ademco, Syosset, NY USA. [Corteselli, Stephen] Alcatel Lucent Bell Labs, Murray Hill, NJ USA. [Goode, Edward H.] Alcatel Lucent Opt Div, Murray Hill, NJ USA. [Buhl, Lawrence L.] USA, Signal Corps, Ft Monmouth, NJ USA. [Xia, Tiejun] Univ Texas Dallas, Dallas, TX 75230 USA. [Xia, Tiejun] Univ Michigan, Dept Elect Engn, Ann Arbor, MI 48109 USA. [Lee, Wang] New York Tel Co, New York, NY USA. [Lyons, Greg] Verizon Natl Network Management Ctr, Scheduled Act Request Team, Reston, VA USA. [Hofmann, Peter] Verizon Global Network Planning Org, Boston, MA USA. [Basch, E. Bert] GTE Labs Inc, Waltham, MA USA. [Kluge, William J.] Verizon FiOS Video Serv, Basking Ridge, NJ USA. [Gatewood, Johnny R.] Verizon Serv Org, Global Transport Network Management Org, Cary, NC USA. [Kawanishi, Tetsuya] Natl Inst Informat & Communicat Technol, Tokyo, Japan. [Kawanishi, Tetsuya] Kyoto Univ, Venture Business Lab, Kyoto 6068501, Japan. [Higuma, Kaoru] Sumitomo Osaka Cement Co Ltd, Optoelect Res Div, New Technol Res Labs, Chiba, Japan. [Painchaud, Yves] TeraXion, Quebec City, PQ, Canada. NR 49 TC 5 Z9 5 U1 1 U2 5 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1089-7089 J9 BELL LABS TECH J JI Bell Labs Tech. J. PD WIN PY 2010 VL 14 IS 4 BP 85 EP 113 DI 10.1002/bltj.20406 PG 29 WC Computer Science, Information Systems; Engineering, Electrical & Electronic; Telecommunications SC Computer Science; Engineering; Telecommunications GA 566NY UT WOS:000275380400008 ER PT J AU Zander, NE Orlicki, JA Rawlett, AM Beebe, TP AF Zander, Nicole E. Orlicki, Joshua A. Rawlett, Adam M. Beebe, Thomas P., Jr. TI Surface-modified nanofibrous biomaterial bridge for the enhancement and control of neurite outgrowth SO BIOINTERPHASES LA English DT Article ID PERIPHERAL-NERVE REGENERATION; NEURAL STEM-CELLS; ELECTROSPUN NANOFIBERS; FIBROUS SCAFFOLDS; IN-VITRO; IMMOBILIZATION; GROWTH; GUIDANCE; FABRICATION; ALIGNMENT AB Biomaterial bridges constructed from electrospun fibers offer a promising alternative to traditional nerve tissue regeneration substrates. Aligned and unaligned polycaprolactone (PCL) electrospun fibers were prepared and functionalized with the extracellular matrix proteins collagen and laminin using covalent and physical adsorption attachment chemistries. The effect of the protein modified and native PCL nanofiber scaffolds on cell proliferation, neurite outgrowth rate, and orientation was examined with neuronlike PC12 cells. All protein modified scaffolds showed enhanced cellular adhesion and neurite outgrowth compared to unmodified PCL scaffolds. Neurite orientation was found to be in near perfect alignment with the fiber axis for cells grown on aligned fibers, with difference angles of less than 7 degrees from the fiber axis, regardless of the surface chemistry. The bioavailability of PCL fibers with covalently attached laminin was found to be identical to that of PCL fibers with physically adsorbed laminin, indicating that the covalent chemistry did not change the protein conformation into a less active form and the covalent attachment of protein is a suitable method for enhancing the biocompatibility of tissue engineering scaffolds. (c) 2010 American Vacuum Society. [DOI: 10.1116/1.3526140] C1 [Zander, Nicole E.; Orlicki, Joshua A.; Rawlett, Adam M.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Zander, Nicole E.; Beebe, Thomas P., Jr.] Univ Delaware, Dept Chem & Biochem, Newark, DE 19716 USA. RP Zander, NE (reprint author), USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM nicole.zander@arl.army.mil NR 42 TC 22 Z9 23 U1 3 U2 37 PU AVS PI RESEARCH TRIANGLE PARK PA EDITORIAL OFFICE, 100 PARK DR, STE 105, CALLER BOX 13994, RESEARCH TRIANGLE PARK, NC 27709 USA SN 1559-4106 J9 BIOINTERPHASES JI Biointerphases PD DEC PY 2010 VL 5 IS 4 BP 149 EP 158 DI 10.1116/1.3526140 PG 10 WC Biophysics; Materials Science, Biomaterials SC Biophysics; Materials Science GA 703JO UT WOS:000285974400008 PM 21219036 ER PT J AU Chowbina, S Deng, YP Ai, JM Wu, XG Guan, X Wilbanks, MS Escalon, BL Meyer, SA Perkins, EJ Chen, JY AF Chowbina, Sudhir Deng, Youping Ai, Junmei Wu, Xiaogang Guan, Xin Wilbanks, Mitchell S. Escalon, Barbara Lynn Meyer, Sharon A. Perkins, Edward J. Chen, Jake Y. TI A new approach to construct pathway connected networks and its application in dose responsive gene expression profiles of rat liver regulated by 2,4DNT SO BMC GENOMICS LA English DT Article ID MUNITIONS CONSTITUENTS; SIGNALING PATHWAY; EISENIA-FOETIDA; TOXICITY; CANCER; 2,4,6-TRINITROTOLUENE; MECHANISMS; DISEASE; RDX AB Background: Military and industrial activities have lead to reported release of 2,4-dinitrotoluene (2,4DNT) into soil, groundwater or surface water. It has been reported that 2,4DNT can induce toxic effects on humans and other organisms. However the mechanism of 2,4DNT induced toxicity is still unclear. Although a series of methods for gene network construction have been developed, few instances of applying such technology to generate pathway connected networks have been reported. Results: Microarray analyses were conducted using liver tissue of rats collected 24h after exposure to a single oral gavage with one of five concentrations of 2,4DNT. We observed a strong dose response of differentially expressed genes after 2,4DNT treatment. The most affected pathways included: long term depression, breast cancer regulation by stathmin1, WNT Signaling; and PI3K signaling pathways. In addition, we propose a new approach to construct pathway connected networks regulated by 2,4DNT. We also observed clear dose response pathway networks regulated by 2,4DNT. Conclusions: We developed a new method for constructing pathway connected networks. This new method was successfully applied to microarray data from liver tissue of 2,4DNT exposed animals and resulted in the identification of unique dose responsive biomarkers in regards to affected pathways. C1 [Deng, Youping] Rush Univ, Ctr Canc, Med Ctr, Chicago, IL 60612 USA. [Chowbina, Sudhir; Wu, Xiaogang; Chen, Jake Y.] Indiana Univ, Sch Informat, Indianapolis, IN 46202 USA. [Ai, Junmei] Univ So Mississippi, Sch Comp, Hattiesburg, MS 39406 USA. [Guan, Xin] SpecProc Inc, Vicksburg, MS 39180 USA. [Wilbanks, Mitchell S.; Escalon, Barbara Lynn; Perkins, Edward J.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Meyer, Sharon A.] Univ Louisiana Monroe, Dept Toxicol, Monroe, LA 70804 USA. [Chen, Jake Y.] Purdue Sch Sci, Dept Comp & Informat Sci, Indianapolis, IN 46202 USA. [Chen, Jake Y.] Indiana Ctr Syst Biol & Personalized Med, Indianapolis, IN 46202 USA. RP Deng, YP (reprint author), Rush Univ, Ctr Canc, Med Ctr, Chicago, IL 60612 USA. EM youping_deng@rush.edu; jakechen@iupui.edu FU US Army [W912HZ-05-P-0145]; International Society of Intelligent Biological Medicine (ISIBM) FX This project was supported by US Army Environmental Quality Program (contract #W912HZ-05-P-0145). Publication of this supplement was made possible with support from the International Society of Intelligent Biological Medicine (ISIBM). NR 25 TC 3 Z9 3 U1 1 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD DEC 1 PY 2010 VL 11 SU 3 AR S4 DI 10.1186/1471-2164-11-S3-S4 PG 8 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA 745WC UT WOS:000289200400005 PM 21143786 ER PT J AU Brunye, TT Mahoney, CR Lieberman, HR Giles, GE Taylor, HA AF Brunye, Tad T. Mahoney, Caroline R. Lieberman, Harris R. Giles, Grace E. Taylor, Holly A. TI Acute caffeine consumption enhances the executive control of visual attention in habitual consumers SO BRAIN AND COGNITION LA English DT Article DE Caffeine; Arousal; Attention networks; Visuospatial attention ID ANTERIOR CINGULATE CORTEX; WORKING-MEMORY; PREFRONTAL CORTEX; VIGILANCE PERFORMANCE; COGNITIVE PERFORMANCE; SELECTIVE ATTENTION; ADENOSINE RECEPTORS; INHIBITORY CONTROL; CEREBRAL-CORTEX; DOPAMINE AB Recent work suggests that a dose of 200-400 mg caffeine can enhance both vigilance and the executive control of visual attention in individuals with low caffeine consumption profiles. The present study seeks to determine whether individuals with relatively high caffeine consumption profiles would show similar advantages. To this end, we examined the effects of four caffeine doses (0 mg, 100 mg, 200 mg, 400 mg) on low- and high-level visual attention in individuals with high consumption profiles (n = 36), in a double-blind study using a repeated measures design. Results from the Attention Network Test indicated that caffeine enhanced both vigilance and the executive control of visual attention, but only at the highest administered dose (400 mg). We demonstrate that in habitual consumers high doses of caffeine can produce beneficial changes in visual attention. These results carry implications for the theorized interactions between caffeine, adenosine and dopamine in brain regions mediating visual attention. Published by Elsevier Inc. C1 [Brunye, Tad T.; Mahoney, Caroline R.; Giles, Grace E.] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. [Brunye, Tad T.; Mahoney, Caroline R.; Giles, Grace E.; Taylor, Holly A.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. [Lieberman, Harris R.] USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Brunye, TT (reprint author), US Army Natick Soldier Res, Ctr Dev & Engn, 15 Kansas St, Natick, MA 01760 USA. EM tbruny01@tufts.edu NR 83 TC 22 Z9 24 U1 1 U2 21 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0278-2626 J9 BRAIN COGNITION JI Brain Cogn. PD DEC PY 2010 VL 74 IS 3 BP 186 EP 192 DI 10.1016/j.bandc.2010.07.006 PG 7 WC Neurosciences; Psychology, Experimental SC Neurosciences & Neurology; Psychology GA 679SY UT WOS:000284182300002 PM 20832925 ER PT J AU Marble, S AF Marble, Sanders TI War, Politics, and Philanthropy: The History of Rehabilitation Medicine SO BULLETIN OF THE HISTORY OF MEDICINE LA English DT Book Review C1 [Marble, Sanders] USA, Med Command, Off Med Hist, Washington, DC 20310 USA. RP Marble, S (reprint author), USA, Med Command, Off Med Hist, Washington, DC 20310 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU JOHNS HOPKINS UNIV PRESS PI BALTIMORE PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD 21218-4363 USA SN 0007-5140 EI 1086-3176 J9 B HIST MED JI Bull. Hist. Med. PD WIN PY 2010 VL 84 IS 4 BP 691 EP 692 PG 2 WC Health Care Sciences & Services; History & Philosophy Of Science SC Health Care Sciences & Services; History & Philosophy of Science GA 703ZF UT WOS:000286019800013 ER PT J AU Glasser, JS Guymon, CH Mende, K Wolf, SE Hospenthal, DR Murray, CK AF Glasser, Jessie S. Guymon, Charles H. Mende, Katrin Wolf, Steven E. Hospenthal, Duane R. Murray, Clinton K. TI Activity of topical antimicrobial agents against multidrug-resistant bacteria recovered from burn patients SO BURNS LA English DT Article DE Burn; Topical ID SILVER SULFADIAZINE; MAFENIDE-ACETATE; IN-VITRO; ACINETOBACTER-BAUMANNII; PSEUDOMONAS-AERUGINOSA; STAPHYLOCOCCUS-AUREUS; WOUND INFECTIONS; MUPIROCIN; HONEY; EFFICACY AB Background Topical antimicrobials are employed for prophylaxis and treatment of burn wound infections despite no established susceptibility breakpoints which are becoming vital in an era of multidrug resistant (MDR) bacteria We compared two methods of determining topical antimicrobial susceptibilities Methods Isolates of Pseudomonas aeruginosa methicillin resistant Staphylococcus aureus (MASA) extended spectrum beta lactamase (ESBL) producing Klebsiella pneumoniae and Acinetobacter baumanii calcoaceticus (ABC) from burn patients were tested using broth micro dilution and agar well diffusion to determine minimum inhibitory concentrations (MICs) and zones of inhibition (ZI) Isolates had systemic antibiotic resistance and clonality determined MDR included resistance to antibiotics in three or more classes Results We assessed 22 ESBL producing K pneumoniae 20 ABC (75% MDR) 20 P aeruginosa (45% MDR) and 20 MRSA isolates The most active agents were mupirocin for MRSA and mafenide acetate for the gram negatives with moderate MICs/ZI found with silver sulfa diazene silver nitrate and honey MDR and non MDR isolates had similar topical resistance There was no clonality associated with resistance patterns Conclusion Despite several methods to test bacteria for topical susceptibility no defined breakpoints exist and standards need to be established We recommend continuing to use silver products for prophylaxis against gram negatives and mafenide acetate for treatment and mupirocin for MRSA Published by Elsevier Ltd and ISBI C1 [Murray, Clinton K.] Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Guymon, Charles H.; Wolf, Steven E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Mende, Katrin] Infect Dis Clin Res Program, Bethesda, MD USA. [Wolf, Steven E.; Hospenthal, Duane R.; Murray, Clinton K.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Hospenthal, Duane R.; Murray, Clinton K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. RI Valle, Ruben/A-7512-2013; OI Wolf, Steven/0000-0003-2972-3440 NR 62 TC 20 Z9 23 U1 2 U2 13 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 J9 BURNS JI Burns PD DEC PY 2010 VL 36 IS 8 BP 1172 EP 1184 DI 10.1016/j.burns.2010.05.013 PG 13 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 684TA UT WOS:000284571000004 PM 20542641 ER PT J AU Karpov, KA Bergen, M Geibel, JJ Law, PM Valle, CF Fox, D AF Karpov, Konstantin A. Bergen, Mary Geibel, John J. Law, Philip M. Valle, Charles F. Fox, David TI PROSPECTIVE (A PRIORI) POWER ANALYSIS FOR DETECTING CHANGES IN DENSITY WHEN SAMPLING WITH STRIP TRANSECTS SO CALIFORNIA FISH AND GAME LA English DT Article DE monitoring; power analysis; sampling design; statistical power; transect sampling ID FISHERIES AB When designing a monitoring program, it is important to determine how much sampling is needed prior to data collection. Programs with too little statistical power produce ambiguous results and public debate that cannot be resolved. However, prospective power analysis requires an estimate of sample variance. In this paper, data from strip transect surveys using remote operated vehicle (ROV) of fish on temperate subtidal rocky reefs were used to establish the relationship between density and variance needed for power analysis. The relationship was used to select the optimal sample unit (transect) size and estimate the total sampling effort needed to measure specific changes in density between two sampling study areas. In general, smaller transects were more efficient than larger transects. The smallest transects (50 m(2)) were most efficient, but the difference between 50-m(2) transects and 100-, 200-, and 400-m(2) transects was relatively small (11% to 28%). The largest transects (800 m(2)), however, required 57% more sampling area than 50-m(2) transects. The total sampling area needed to detect a significant difference in density increased with decreasing effect size, as expected. Also as expected, some species (e.g. copper rockfish) required more sampling effort than others (e.g. vermilion rockfish). These results demonstrate that pre-existing data may be used to establish relationships between means and variances, and to determine the optimal transect size and the amount of sampling effort needed to measure statistically significant differences in fish density between study areas. C1 [Karpov, Konstantin A.] Karpov Marine Biol Res, Ft Bragg, CA 95437 USA. [Geibel, John J.] Calif Dept Fish & Game, Menlo Pk, CA 95025 USA. [Law, Philip M.] Calif Dept Fish & Game, Belmont, CA 94002 USA. [Valle, Charles F.] Calif Dept Fish & Game, Los Alamitos, CA 90720 USA. [Fox, David] Oregon Dept Fish & Wildlife, Newport, OR 97365 USA. RP Karpov, KA (reprint author), Karpov Marine Biol Res, 24752 Sashandre Lane, Ft Bragg, CA 95437 USA. EM kkarpov1@gmail.com FU NOAA office of Ocean and Coastal Resource Management FX Special thanks to A. Lauermann of Pacific States Marine Fisheries Commission (PSMFC) for help in the sampling design, field data collection, and analysis. Thanks to C. Pattison and M. Prall of DFG for field support and sampling design. Special thanks to S. Ahlgren, Y. Yokozawa, and E. Jacobsen of PSMFC for assistance with analysis and graphics in this paper. Special thanks are due to N. Kogut and M. Patyten of DFG, and E. Jacobsen for help in editing this manuscript. Thanks to Stan Allen of PSMFC for administrative and staffing support. Thanks to M. Amend, B. Stave, and A. Merems of Oregon Department of Fish and Wildlife (ODFW) for data collection, sampling design, and analysis. Thanks are due to D. Rosen of Marine Applied Research and Exploration (MARE) for participating in field operations and fundraising. We also thank S. Holtz of MARE and the Institute of Fisheries Research for contributing to field operations in southern and central California. C. Mobley, K. Peet, and S. Fangman from the Channel Islands National Marine Sanctuary provided vessel support. L. Moody and T. Shinn captained the R/V Shearwater, and E. Schnaubelt and P. York captained the F/V Marlene Rose and the R/V Elakha, respectively. Thanks to R. Kvitek of California State University, Monterey Bay, G. Cochrane of the United States Geological Survey, and T. Sullivan of Seavisual Consulting for seafloor mapping. Primary support was provided to DFG from the Sportfish Restoration Act with additional support from the Ocean Protection Council, The Nature Conservancy, and the North East Assistance Program. Support for ODFW was provided by Oregon Department of Land Conservation and Development through a grant from the NOAA office of Ocean and Coastal Resource Management. Finally, we wish to thank G. Stacey, M. Vojkovich, P. Wolf, P. Coulston, and J. Ugoretz for their support as DFG managers. NR 18 TC 4 Z9 4 U1 1 U2 5 PU CALIFORNIA FISH AND GAME EDITOR PI SACRAMENTO PA 1416 NINTH ST, SACRAMENTO, CA 95814 USA SN 0008-1078 J9 CALIF FISH GAME JI Calif. Fish Game PD WIN PY 2010 VL 96 IS 1 BP 69 EP 81 PG 13 WC Fisheries; Zoology SC Fisheries; Zoology GA 670ZS UT WOS:000283469500006 ER PT J AU Bednar, AJ Chappell, MA Seiter, JM Stanley, JK Averett, DE Jones, WT Pettway, BA Kennedy, AJ Hendrix, SH Steevens, JA AF Bednar, A. J. Chappell, M. A. Seiter, J. M. Stanley, J. K. Averett, D. E. Jones, W. T. Pettway, B. A. Kennedy, A. J. Hendrix, S. H. Steevens, J. A. TI Geochemical investigations of metals release from submerged coal fly ash using extended elutriate tests SO CHEMOSPHERE LA English DT Article DE Fly ash; Dredging; Speciation; Metal mobility ID FUEL COMBUSTION RESIDUES; INORGANIC CONSTITUENTS; POWER-PLANT; PH; MOBILIZATION; SPECIATION; STABILITY; OXIDATION; STANDARD; ELEMENTS AB A storage pond dike failure occurred at the Tennessee Valley Authority Kingston Fossil Plant that resulted in the release of over 3.8 million cubic meters (5 million cubic yards) of fly ash. Approximately half of this material deposited in the main channel of the Emory River, 3 5 km upstream of the confluence of the Emory and Clinch Rivers, Tennessee, USA Remediation efforts to date have focused on targeted removal of material from the channel through hydraulic dredging, as well as mechanical excavation in some areas The agitation of the submerged fly ash during hydraulic dredging introduces river water into the fly ash material, which could alter the redox state of metals present in the fly ash and thereby change their sorption and mobility properties. A series of extended elutriate tests were used to determine the concentration and speciation of metals released from fly ash. Results indicated that arsenic and selenium species released from the fly ash materials during elutriate preparation were redox stable over the course of 10 d, with dissolved arsenic being present as arsenate, and dissolved selenium being present as selenite. Concentrations of certain metals, such as arsenic. selenium, vanadium, and barium, increased in the elutriate waters over the 10 d study, whereas manganese concentrations decreased, likely due to oxidation and precipitation reactions. Published by Elsevier Ltd C1 [Bednar, A. J.; Chappell, M. A.; Seiter, J. M.; Stanley, J. K.; Averett, D. E.; Jones, W. T.; Pettway, B. A.; Kennedy, A. J.; Hendrix, S. H.; Steevens, J. A.] USA, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Bednar, AJ (reprint author), USA, Engn Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. RI Schneider, Larissa/C-9863-2012 NR 33 TC 22 Z9 22 U1 1 U2 25 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD DEC PY 2010 VL 81 IS 11 BP 1393 EP 1400 DI 10.1016/j.chemosphere.2010.09.026 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA 690UT UT WOS:000285034700004 PM 20943255 ER PT J AU Jacobson, IM Cacoub, P Dal Maso, L Harrison, SA Younossi, ZM AF Jacobson, Ira M. Cacoub, Patrice Dal Maso, Luigino Harrison, Stephen A. Younossi, Zobair M. TI Manifestations of Chronic Hepatitis C Virus Infection Beyond the Liver SO CLINICAL GASTROENTEROLOGY AND HEPATOLOGY LA English DT Article DE Hepatitis C Virus; Burden of Disease; Extrahepatic Comorbidities; Health-Related Quality of Life; Epidemiology ID QUALITY-OF-LIFE; SUSTAINED VIROLOGICAL RESPONSE; MIXED CRYOGLOBULINEMIA VASCULITIS; CELL CLONAL DISORDERS; NON-HODGKINS-LYMPHOMA; INSULIN-RESISTANCE; SJOGRENS-SYNDROME; EXTRAHEPATIC MANIFESTATIONS; ANTIVIRAL THERAPY; DIABETES-MELLITUS AB In addition to its effects in the liver, chronic hepatitis C virus (HCV) infection can have serious consequences for other organ systems. Extrahepatic manifestations include mixed cryoglobulinemia (MC) vasculitis, lymphoproliferative disorders, renal disease, insulin resistance, type 2 diabetes, sicca syndrome, rheumatoid arthritis-like polyarthritis, and autoantibody production; reductions in quality of life involve fatigue, depression, and cognitive impairment. MC vasculitis, certain types of lymphoma, insulin resistance, and cognitive function appear to respond to anti-HCV therapy. However, treatments for HCV and other biopsychosocial factors can reduce quality of life and complicate management. HCV treatment has a high overall cost that increases when extrahepatic manifestations are considered. HCV appears to have a role in the pathogenesis of MC vasculitis, certain types of lymphoma, and insulin resistance. Clinicians who treat patients with HCV infections should be aware of potential extrahepatic manifestations and how these can impact and alter management of their patients. C1 [Jacobson, Ira M.] Cornell Univ, Div Gastroenterol & Hepatol, Ctr Study Hepatitis C, Joan & Sanford I Weill Med Coll, New York, NY 10021 USA. [Cacoub, Patrice] Univ Paris 06, Dept Internal Med, Hop La Pitie Salpetriere, Paris, France. [Dal Maso, Luigino] Aviano Canc Ctr, Epidemiol & Biostat Unit, I-33081 Aviano, Italy. [Harrison, Stephen A.] Brooke Army Med Ctr, Dept Gastroenterol, San Antonio, TX USA. [Younossi, Zobair M.] Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA USA. RP Jacobson, IM (reprint author), Cornell Univ, Div Gastroenterol & Hepatol, Ctr Study Hepatitis C, Joan & Sanford I Weill Med Coll, 1305 York Ave, New York, NY 10021 USA. EM imj2001@med.cornell.edu OI dal maso, luigino/0000-0001-6163-200X FU Schering-Plough; Roche; Servier; Encysive; Gilead; Genentech; Merck; Pfizer FX The authors disclose the following: Ira M Jacobson: Vertex Pharmaceuticals Incorporated: consultant (including Advisory Board for manuscript), investigator; Merck: consultant, speaker, and investigator; Gilead Sciences: consultant, speaker, and investigator; Bristol-Myers Squibb: consultant and speaker; Genentech: consultant, speaker, and investigator; Boehringer Ingelheim: consultant and investigator; Pfizer: consultant and investigator; Human Genome Sciences: consultant and investigator; Zymogenetics: consultant and investigator; Anadys: consultant and investigator; Novartis: consultant, speaker, and investigator; Pharmasset: consultant and investigator; GlobeImmune: consultant and investigator; Abbott: consultant and investigator; Tibotec: consultant and investigator; Idenix: investigator; Achillion: consultant; GlaxoSmithKline: consultant. Patrice Cacoub: Vertex Pharmaceuticals Incorporated: consultant (Advisory Board for manuscript); Schering-Plough: consultant and research grants; Roche: consultant and research grants; Servier: consultant and research grants; Encysive: consultant and research grants; Gilead: consultant and research grants; AstraZeneca: consultant; Bristol-Myers Squibb: consultant; Sanofi Aventis: consultant. Luigino Dal Maso: Vertex Pharmaceuticals Incorporated: consultant (Advisory Board for manuscript). Stephen A Harrison: Advisory Boards for Three Rivers Pharmaceuticals, Vertex, and Amylin; Speaker's bureau for Bristol-Myers Squibb and Salix; grant support from Genentech, Merck, and Pfizer. Zobair M Younossi: Vertex Pharmaceuticals Incorporated: consultant and Advisory Boards, investigator; GlobeImmune: consultant; Salix: Advisory Board; Sanofi-Aventis: consultant; Tibotec: advisory board. NR 154 TC 63 Z9 66 U1 1 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1542-3565 J9 CLIN GASTROENTEROL H JI Clin. Gastroenterol. Hepatol. PD DEC PY 2010 VL 8 IS 12 BP 1017 EP 1029 DI 10.1016/j.cgh.2010.08.026 PG 13 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 695ZU UT WOS:000285412500010 PM 20870037 ER PT J AU Noedl, H Se, Y Sriwichai, S Schaecher, K Teja-Isavadharm, P Smith, B Rutvisuttinunt, W Bethell, D Surasri, S Fukuda, MM Socheat, D Thap, LC AF Noedl, Harald Se, Youry Sriwichai, Sabaithip Schaecher, Kurt Teja-Isavadharm, Paktiya Smith, Bryan Rutvisuttinunt, Wiriya Bethell, Delia Surasri, Sittidech Fukuda, Mark M. Socheat, Duong Thap, Lon Chan TI Artemisinin Resistance in Cambodia: A Clinical Trial Designed to Address an Emerging Problem in Southeast Asia SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID PLASMODIUM-FALCIPARUM MALARIA; ARTESUNATE-MEFLOQUINE; COMBINATION THERAPY; SENSITIVITY; MONOTHERAPY; ARTEMETHER; THAILAND; PFMDR1; SUSCEPTIBILITY; MUTATIONS AB Background. Increasing rates of failure of artemisinin-based combination therapy have highlighted the possibility of emerging artemisinin resistance along the Thai-Cambodian border. We used an integrated in vivo-in vitro approach to assess the presence of artemisinin resistance in western Cambodia. This article provides additional data from a clinical trial that has been published in The New England Journal of Medicine. Methods. Ninety-four adult patients from Battambang Province, western Cambodia, who presented with uncomplicated falciparum malaria were randomized to receive high-dose artesunate therapy (4 mg/kg/day orally for 7 days) or quinine-tetracycline. Plasma concentrations of dihydroartemisinin, in vitro drug susceptibility, and molecular markers were analyzed. Cases meeting all the following criteria were classified as artemisinin resistant: failure to clear parasites within 7 days of treatment or reemergence of parasites within 28 days of follow-up; adequate plasma concentrations of dihydroartemisinin; prolonged parasite clearance; and increased in vitro drug susceptibility levels for dihydroartemisinin. Results. Two (3.3%) of 60 artesunate-treated patients were classified as artemisinin resistant. Their parasite clearance times were prolonged (133 and 95 h, compared with a median of 52.2 h in patients who were cured). These patients had 50% inhibitory concentrations of dihydroartemisinin that were almost 10 times higher than the reference clone W2. Resistance did not appear to be mediated by the pfmdr1 copy number or selected PfATPase6 polymorphisms previously proposed to confer artemisinin resistance. Conclusion. Artemisinin resistance has emerged along the Thai-Cambodian border. The potentially devastating implications of spreading resistance to a drug that currently has no successor call for further studies of this emerging problem. C1 [Noedl, Harald] Med Univ Vienna, Inst Specif Prophylaxis & Trop Med, A-1090 Vienna, Austria. [Se, Youry; Sriwichai, Sabaithip; Schaecher, Kurt; Teja-Isavadharm, Paktiya; Smith, Bryan; Rutvisuttinunt, Wiriya; Bethell, Delia; Surasri, Sittidech; Fukuda, Mark M.; Thap, Lon Chan] US Army Med Component Armed Forces Res Inst Med S, Dept Immunol & Med, Bangkok, Thailand. [Socheat, Duong] Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia. RP Noedl, H (reprint author), Med Univ Vienna, Inst Specif Prophylaxis & Trop Med, Kinderspitalgasse 15, A-1090 Vienna, Austria. EM harald.noedl@meduniwien.ac.at RI Valle, Ruben/A-7512-2013 FU Armed Forces Health Surveillance Center-Global Emerging Infections System Program FX Armed Forces Health Surveillance Center-Global Emerging Infections System Program. NR 35 TC 83 Z9 84 U1 0 U2 7 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD DEC 1 PY 2010 VL 51 IS 11 BP E82 EP E89 DI 10.1086/657120 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 675RZ UT WOS:000283850200001 PM 21028985 ER PT J AU Yee, SB Hatkin, JM Dyer, DN Orr, SA Pitt, MLM AF Yee, Steven B. Hatkin, Joshua M. Dyer, David N. Orr, Steven A. Pitt, M. Louise M. TI Aerosolized Bacillus anthracis Infection in New Zealand White Rabbits: Natural History and Intravenous Levofloxacin Treatment SO COMPARATIVE MEDICINE LA English DT Article ID AFRICAN-GREEN MONKEY; INHALATIONAL ANTHRAX; PROTECTIVE ANTIGEN; LETHAL FACTOR; UNITED-STATES; BIOTERRORISM; PATHOLOGY; MODELS; TOXIN; PATHOGENESIS AB The natural history for inhalational Bacillus anthracis (Ames strain) exposure in New Zealand white rabbits was investigated to better identify potential, early biomarkers of anthrax Twelve SPF Bordetella-free rabbits were exposed to 150 LD(50) aerosolized B anthracis spores, and clinical signs, body temperature, complete blood count, bacteremia, and presence of protective antigen in the blood (that is, antigenemia) were examined The development of antigenemia and bacteremia coincided and preceded both pyrexia and inversion of the heterophil lymphocyte ratio, an indicator of infection Antigenemia was determined within 1 h by electrochemiluminescence immunoassay, compared with the 24-h traditional culture needed for bacteremia determination Rabbits appeared clinically normal until shortly before succumbing to anthrax approximately 47 h after challenge or approximately 22 h after antigenemia, which suggests a relatively narrow therapeutic window of opportunity To evaluate the therapeutic rabbit model, B anthracis-exposed rabbits were treated (after determination of antigenemia and later confirmed to be bacteremic) intravenously with the fluoroquinolone antibiotic levofloxacin for 5 d at a total daily dose of 25 or 12 5 mg/kg, resulting in nearly 90% and 70% survival, respectively, to the study end (28 d after challenge) The peak level for 12 5 mg/kg was equivalent to that observed for a 500-mg daily levofloxacin dose in humans These results suggest that intravenous levofloxacin is an effective therapeutic against inhalational anthrax Taken together, our findings indicate that antigenemia is a viable and early biomarker for B anthracis infection that can be used as a treatment trigger to allow for timely intervention against this highly pathogenic disease C1 [Yee, Steven B.; Dyer, David N.; Pitt, M. Louise M.] USA, Ctr Aerobiol Sci, Med Inst Infect Dis USAMRIID, Ft Detrick, MD USA. [Orr, Steven A.] USA, Off Regulated Studies, Med Inst Infect Dis USAMRIID, Ft Detrick, MD USA. [Orr, Steven A.] Clin Res Management, Hinckley, OH USA. [Hatkin, Joshua M.] Penn Vet Diagnost Lab, Harrisburg, PA USA. RP Yee, SB (reprint author), USA, Ctr Aerobiol Sci, Med Inst Infect Dis USAMRIID, Ft Detrick, MD USA. FU National Institute of Allergy and Infectious Diseases Bethesda [Y1 AI 6129-04]; USAMRIID [A 120-B 10 3] FX This research was sponsored through an interagency agreement between the National Institute of Allergy and Infectious Diseases Bethesda (Y1 AI 6129-04) and USAMRIID (A 120-B 10 3) The views opinions and/or findings contained herein are those of the authors and should not be construed as an official Department of Army position policy or decision unless so designated by other documentation The authors do not have a commercial or other association that would pose a conflict of interest NR 49 TC 20 Z9 20 U1 0 U2 4 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1532-0820 J9 COMPARATIVE MED JI Comparative Med. PD DEC PY 2010 VL 60 IS 6 BP 461 EP 468 PG 8 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 699IU UT WOS:000285657900007 PM 21262133 ER EF