FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Divers, SJ Boone, SS Berliner, A Kurimo, EA Boysen, KA Johnson, DR Killgore, KJ George, SG Hoover, JJ AF Divers, Stephen J. Boone, Shaun S. Berliner, Aimee Kurimo, Elizabeth A. Boysen, Krista A. Johnson, David R. Killgore, K. Jack George, Steven G. Hoover, Jan Jeffrey TI NONLETHAL ACQUISITION OF LARGE LIVER SAMPLES FROM FREE-RANGING RIVER STURGEON (SCAPHIRHYNCHUS) USING SINGLE-ENTRY ENDOSCOPIC BIOPSY FORCEPS SO JOURNAL OF WILDLIFE DISEASES LA English DT Article DE Disease diagnosis; endoscopy; fish; liver biopsy; pathology; Scaphirhynchus; sturgeon; toxicology ID FLOWING MISSISSIPPI RIVER; AFRICAN ATLANTIC-OCEAN; PALLID STURGEON; WHITE STURGEON; POLYCHLORINATED-BIPHENYLS; SHOVELNOSE STURGEON; WATER FISH; SHARK; ACIPENSER; GROWTH AB Harvesting of liver samples for toxicologic and other laboratory analyses is frequently undertaken in free-ranging fish to evaluate accumulations of various pollutants and chemicals. However, commonly used, lethal techniques for collecting liver tissues are unacceptable when dealing with protected species. We report the use of a nonlethal, single-entry, endoscopic technique using saline infusion to examine and collect large liver samples using optical biopsy forceps from 16 free-ranging sturgeon (Scaphirhynchus spp.) during 25 and 27 January 2010. Under tricaine methanesulfonate anesthesia and following the introduction of the optical biopsy forceps (with a 5-mm telescope) through a 1-2-cm ventral midline skin incision, liver examination and collection of biopsies averaging 0.9 g, ranging up to 1.4 g, and representing up to 12% of total liver tissue were successful. All fish made uneventful recoveries and necropsy examinations the following day failed to indicate any significant hemorrhage or iatrogenic trauma. We recommend the use of large optical biopsy forceps as a practical, nonlethal alternative for collection of large liver biopsies from sturgeon and other fish. C1 [Divers, Stephen J.; Boone, Shaun S.; Kurimo, Elizabeth A.] Univ Georgia, Coll Vet Med, Dept Small Anim Med & Surg Zool Med, Athens, GA 30602 USA. [Berliner, Aimee] Georgia Aquarium, Atlanta, GA 30313 USA. [Boysen, Krista A.] St Louis Univ, Dept Biol, St Louis, MO 63103 USA. [Johnson, David R.; Killgore, K. Jack; George, Steven G.; Hoover, Jan Jeffrey] USA, Engineer Res & Dev Ctr, Waterways Expt Stn, Vicksburg, MS 39180 USA. RP Divers, SJ (reprint author), Univ Georgia, Coll Vet Med, Dept Small Anim Med & Surg Zool Med, Athens, GA 30602 USA. EM sdivers@uga.edu FU Dredging Operations and Environmental Research program FX This project was funded by the Dredging Operations and Environmental Research program. We are grateful to Christopher Chamness and Karl Storz Endoscopy for building the prototype optical biopsy forceps, and supporting endoscopy research and development at the University of Georgia's College of Veterinary Medicine. Assistance in the field was provided by Jay Collins, Neil Douglas, Kathie Eagles, Nick Friedenberg, Audrey Harrison, Phil Kirk, Bradley Lewis, Thomas Parker, and Todd Slack. Pectoral rays were processed and read by Bradley Lewis and Todd Slack. Site access, working area, electricity, running water, and home-cooked meals were provided by Wanda Landner and her team from Fort Adams, Mississippi. Permission to publish was granted by the US Army Chief of Engineers. NR 41 TC 1 Z9 1 U1 3 U2 14 PU WILDLIFE DISEASE ASSOC, INC PI LAWRENCE PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 USA SN 0090-3558 J9 J WILDLIFE DIS JI J. Wildl. Dis. PD APR PY 2013 VL 49 IS 2 BP 321 EP 331 DI 10.7589/2012-07-203 PG 11 WC Veterinary Sciences SC Veterinary Sciences GA 128YP UT WOS:000317805900012 PM 23568907 ER PT J AU Wolfenstine, J Jo, H Cho, YH David, IN Askeland, P Case, ED Kim, H Choe, H Sakamoto, J AF Wolfenstine, Jeff Jo, Hyungyung Cho, Yong-Hun David, Isabel N. Askeland, Per Case, Eldon D. Kim, Hyunjoong Choe, Heeman Sakamoto, Jeff TI A preliminary investigation of fracture toughness of Li7La3Zr2O12 and its comparison to other solid Li-ion conductors SO MATERIALS LETTERS LA English DT Article DE Batteries; Solid state electrolyte ID MECHANICAL-PROPERTIES; INDENTATION METHOD; GRAIN-SIZE; GARNET; CERAMICS; DEPENDENCE; CRACKING; ALUMINA; ENERGY AB This is the first report of fracture toughness analysis of a new ceramic electrolyte (Li7La3Zr2O12). The fracture toughness was measured using an indentation technique and subsurface crack propagation was analyzed using a novel focused ion beam/scanning electron microscope (FIB-SEM) technique. The fracture toughness of polycrystalline Li7La3Zr2O12 was between 0.86-1.63 MPa root m. FIB-SEM analysis of the indentation cracks suggested that both half-penny and Palmquist cracks were present. The fracture toughness of Li7La3Zr2O12 is comparable to other state of the art ceramic electrolytes such as Li0.33La0.57TiO3 and Li1.3Al0.3Ti1.7(PO4)(3). (C) 2013 Elsevier B.V. All rights reserved. C1 [Wolfenstine, Jeff] USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA. [Jo, Hyungyung; Cho, Yong-Hun; Choe, Heeman] Kookmin Univ, Sch Adv Mat Engn, Seoul 136702, South Korea. [David, Isabel N.; Askeland, Per; Case, Eldon D.; Kim, Hyunjoong; Sakamoto, Jeff] Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA. RP Sakamoto, J (reprint author), Michigan State Univ, Dept Chem Engn & Mat Sci, 2527 Michigan State Univ, E Lansing, MI 48824 USA. EM jsakamot@msu.edu RI Choe, Heeman/J-4053-2013 OI Choe, Heeman/0000-0002-5908-577X FU US Army Research Laboratory (ARL); Basic Science Research Program [2010-0005775]; Pioneer Research Center Program [2011-0001684]; Priority Research Centers Program [2009-0093814]; National Research Foundation of Korea (NRF); Ministry of Education, Science and Technology FX JW and JS would like to acknowledge the support of the US Army Research Laboratory (ARL). HC also acknowledges supports from the Basic Science Research Program (2010-0005775), the Pioneer Research Center Program (2011-0001684), and the Priority Research Centers Program (2009-0093814) through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology. NR 28 TC 9 Z9 9 U1 4 U2 84 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-577X J9 MATER LETT JI Mater. Lett. PD APR 1 PY 2013 VL 96 BP 117 EP 120 DI 10.1016/j.matlet.2013.01.021 PG 4 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA 127LT UT WOS:000317701200030 ER PT J AU Clayton, JD AF Clayton, J. D. TI Mesoscale modeling of dynamic compression of boron carbide polycrystals SO MECHANICS RESEARCH COMMUNICATIONS LA English DT Article DE Finite strain; Intrinsic stability; Shock compression; Ceramic crystal; Numerical simulation ID NONLINEAR ELASTICITY; RELATIVE STRENGTHS; STABILITY-CRITERIA; PLASTICITY; PRESSURE; FRACTURE; DAMAGE; TEMPERATURE; INSTABILITY; CONSTANTS AB An anisotropic nonlinear elastic model is advanced for crystals belonging to either of two polytypes of boron carbide ceramic. Crystals undergo transformation to an isotropic, amorphous phase upon attainment of a local state-based criterion associated with a loss of intrinsic stability. The model is implemented using the dynamic finite element method, and is demonstrated on a representative volume consisting of fifty polyhedral grains subjected to uniaxial strain at a uniform high strain rate and shock compression at axial pressures ranging from 10 to 50 GPa. Predicted stress-strain behavior is in close agreement with experimental data. For polycrystals consisting of both polytypes, amorphization initiates at stress levels slightly below the experimental Hugoniot elastic limit, and occurs more readily than observed in experiment. For polycrystals consisting only of the CBC (polar) polytype, amorphization initiates at impact pressures similar to those suggested by experiment. In either case, transformation is promoted by dynamic stress interactions and elastic coefficient mismatch among anisotropic crystals. Results support a previous conjecture that amorphization is related to shear instability and cross-linking of the CBC chain in the polar polytype. Published by Elsevier Ltd. C1 USA, RDRL WMP C, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Clayton, JD (reprint author), USA, RDRL WMP C, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM john.d.clayton1.civ@mail.mil RI Clayton, John/C-7760-2009 NR 43 TC 5 Z9 5 U1 0 U2 16 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0093-6413 J9 MECH RES COMMUN JI Mech. Res. Commun. PD APR PY 2013 VL 49 BP 57 EP 64 DI 10.1016/j.mechrescom.2013.02.005 PG 8 WC Mechanics SC Mechanics GA 129AR UT WOS:000317811300009 ER PT J AU Casey, DP Curry, TB Charkoudian, N Joyner, MJ Hart, EC AF Casey, Darren P. Curry, Timothy B. Charkoudian, Nisha Joyner, Michael J. Hart, Emma C. TI The Effects of Acute Beta-Adrenergic Blockade on Aortic Wave Reflection in Postmenopausal Women SO AMERICAN JOURNAL OF HYPERTENSION LA English DT Article DE aortic wave reflection; beta-adrenergic receptors; blood pressure; hypertension; menopause ID CENTRAL BLOOD-PRESSURE; ISOLATED SYSTOLIC HYPERTENSION; ARTERIAL STIFFNESS; AUGMENTATION INDEX; HEART-RATE; ATENOLOL; NEBIVOLOL; BLOCKERS; HUMANS; FORM AB BACKGROUND Acute beta-adrenergic blockade increases aortic-wave reflection in young women. However, it is not known whether this effect extends to postmenopausal women. We therefore examined the effect of systemic beta-adrenergic blockade on aortic wave reflection in 14 postmenopausal women with a mean age of 58 +/- 2 years. METHODS Aortic pressure waveforms were synthesized noninvasively from high-fidelity radial pressure waveforms obtained through applanation tonometry before and during systemic beta-blockade with propranolol given in a bolus dose of 0.25 mg/kg, followed by a continuous infusion at 0.004 mg/kg/min. To further examine the effects of acute beta-blockade on aortic-wave reflection in postmenopausal women, we compared the changes in hemodynamics and indices of aortic-wave reflection with published data from a previous study with a protocol identical to that in the present study but which involved young women. RESULTS Acute beta-blockade increased the aortic augmentation index (AI(x)) in postmenopausal women (32 +/- 2% vs. 35 +/- 2%, P < 0.01). However, AI(x) adjusted for a heart rate of 75 bpm (AI(x)75) was unchanged (25 +/- 2% vs. 24 +/- 2%, P > 0.05). The changes in AI(x), AI(x)75, and the amplitude of reflected waves (augmented aortic pressure) during beta-blockade were all substantially smaller in postmenopausal women than in their younger counterparts (P < 0.05). CONCLUSIONS As compared with those in our previously published study involving young women, indices of aortic-wave reflection were significantly less affected by acute systemic beta-adrenergic blockade in the postmenopausal women in the present study. Taken together, our data suggest that the negative effects (i.e. increased aortic wave reflection) of nonselective beta-adrenergic blockade are less pronounced in postmenopausal than in young women. C1 [Casey, Darren P.; Curry, Timothy B.; Joyner, Michael J.] Mayo Clin, Dept Anesthesiol, Rochester, MN 55905 USA. [Casey, Darren P.] Mayo Clin, Dept Physiol & Biomed Engn, Rochester, MN USA. [Charkoudian, Nisha] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Hart, Emma C.] Univ Bristol, Sch Physiol & Pharmacol, Bristol, Avon, England. RP Casey, DP (reprint author), Mayo Clin, Dept Anesthesiol, Rochester, MN 55905 USA. EM casey.darren@mayo.edu OI Hart, Emma/0000-0002-4534-9586 FU National Institutes of Health (Mayo Clinic) [HL083947, HL46493, AR55819, DK082424, CTSA RR-024150]; Mayo Clinic Research Subcommittee Early Career Development Supplement; American Heart Association [2170087] FX The authors are grateful to the study volunteers for their participation. They also thank Shelly Roberts, Jean Knutson, Karen Krucker, Christopher Johnson, Nancy Meyer, and Pam Engrav for their technical assistance. This study was supported by National Institutes of Health grants HL083947, HL46493, AR55819, DK082424, and CTSA RR-024150 (Mayo Clinic), by a Mayo Clinic Research Subcommittee Early Career Development Supplement, and by American Heart Association grant 2170087 (ECH). NR 38 TC 2 Z9 2 U1 0 U2 3 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0895-7061 J9 AM J HYPERTENS JI Am. J. Hypertens. PD APR PY 2013 VL 26 IS 4 BP 503 EP 510 DI 10.1093/ajh/hps074 PG 8 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 122LP UT WOS:000317319900008 PM 23467206 ER PT J AU Labare, MP Soohoo, H Kim, D Tsoi, KY Liotta, JL Bowman, DD AF Labare, Michael P. Soohoo, Hilary Kim, Dong Tsoi, Key Yan Liotta, Janice L. Bowman, Dwight D. TI Ineffectiveness of a quaternary ammonium salt and povidone-iodine for the inactivation of Ascaris suum eggs SO AMERICAN JOURNAL OF INFECTION CONTROL LA English DT Article DE Ascaris; Iodine; Disinfectant; Quaternary ammonium salt ID LUMBRICOIDES; SLUDGE; OVA AB Two commonly used disinfectants, a quaternary ammonium salt and povidone-iodine, were tested for effectiveness against unembryonated Ascaris suum eggs. The quaternary ammonium salt (alkyl dimethyl benzyl ammonium chloride) had no effect on the Ascaris eggs (10 minutes and 22 degrees C) when compared with the controls in water with egg viabilities of 88.8% +/- 3.3% and 86.9% +/- 6.2%, respectively. An additional quaternary ammonium salt, 2.5% benzethonium chloride, also had no effect. Phenol (5%) and cresol (3%) completely inactivated the eggs. Povidone-iodine at 100%, 50%, 10%, and 1% had no effect on the eggs at exposures of 5, 15, 30, 60, or 120 minutes (22 degrees C) compared with the water controls. Published by Elsevier Inc. on behalf of Association for Professionals in Infection Control and Epidemiology, Inc. C1 [Labare, Michael P.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. [Soohoo, Hilary; Kim, Dong; Tsoi, Key Yan; Liotta, Janice L.; Bowman, Dwight D.] Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Ithaca, NY 14853 USA. RP Labare, MP (reprint author), US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. EM michael.labare@usma.edu NR 10 TC 5 Z9 5 U1 1 U2 16 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-6553 J9 AM J INFECT CONTROL JI Am. J. Infect. Control PD APR PY 2013 VL 41 IS 4 BP 360 EP 361 DI 10.1016/j.ajic.2012.05.013 PG 2 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 123UG UT WOS:000317416000017 PM 23102984 ER PT J AU Biberoglu, K Schopfer, LM Saxena, A Tacal, O Lockridge, O AF Biberoglu, Kevser Schopfer, Lawrence M. Saxena, Ashima Tacal, Ozden Lockridge, Oksana TI Polyproline tetramer organizing peptides in fetal bovine serum acetylcholinesterase SO BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS LA English DT Article DE Fetal bovine serum acetylcholinesterase; Polyproline peptide; Mass spectrometry; PAGE gel electrophoresis; Tetramer organization ID TANDEM MASS-SPECTROMETRY; PROLINE-RICH PEPTIDES; QUATERNARY ASSOCIATIONS; ATTACHMENT DOMAIN; MEMBRANE ANCHOR; COLLAGEN TAIL; GAS-PHASE; BUTYRYLCHOLINESTERASE; FRAGMENTATIONS; PURIFICATION AB Acetylcholinesterase (AChE) in the serum of fetal cow is a tetramer. The related enzyme, butyrylcholinesterase (BChE), in the sera of humans and horse requires polyproline peptides for assembly into tetramers. Our goal was to determine whether soluble tetrameric AChE includes tetramer organizing peptides in, its structure. Fetal bovine serum AChE was denatured by boiling to release non-covalently bound peptides. Bulk protein was separated from peptides by filtration and by high performance liquid chromatography. Peptide mass and amino acid sequence of the released peptides were determined by MALDI-TOF-TOF and LTQ-Orbitrap mass spectrometry. Twenty polyproline peptides, divided into 5 families, were identified. The longest peptide contained 25 consecutive prolines and no other amino acid. Other polyproline peptides included one non-proline amino acid, for example serine at the C-terminus of 20 prolines. A search of the mammalian proteome database suggested that this assortment of polyproline peptides originated from at least 5 different precursor proteins, none of which were the ColQ or PRiMA of membrane-anchored AChE. To date, AChE and BChE are the only proteins known that include polyproline tetramer organizing peptides in their tetrameric structure. (C) 2013 Elsevier B.V. All rights reserved. C1 [Biberoglu, Kevser; Tacal, Ozden] Hacettepe Univ, Sch Pharm, Dept Biochem, TR-06100 Ankara, Turkey. [Schopfer, Lawrence M.; Lockridge, Oksana] Univ Nebraska Med Ctr, Eppley Inst, Omaha, NE 68198 USA. [Saxena, Ashima] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Schopfer, LM (reprint author), Univ Nebraska Med Ctr, Eppley Inst, Omaha, NE 68198 USA. EM Kevser.biberoglu@gmail.com; lmschopf@unmc.edu; ashima.saxena@us.army.mil; otacal@yahoo.com; olockrid@unmc.edu FU TUBITAK grant from the Scientific and Technological Research Council of Turkey; Hacettepe University; NIH [P30CA36727] FX This work was supported by a TUBITAK grant from the Scientific and Technological Research Council of Turkey to OT, a fellowship from Hacettepe University to KB, and NIH grant P30CA36727 to the Eppley Cancer Center. NR 30 TC 5 Z9 5 U1 0 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1570-9639 J9 BBA-PROTEINS PROTEOM JI BBA-Proteins Proteomics PD APR PY 2013 VL 1834 IS 4 BP 745 EP 753 DI 10.1016/j.bbapap.2013.01.009 PG 9 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 124GR UT WOS:000317452300004 PM 23352838 ER PT J AU Doty, TJ Japee, S Ingvar, M Ungerleider, LG AF Doty, Tracy J. Japee, Shruti Ingvar, Martin Ungerleider, Leslie G. TI Fearful Face Detection Sensitivity in Healthy Adults Correlates With Anxiety-Related Traits SO EMOTION LA English DT Article DE intersubject variability; masked fearful faces; state anxiety; neuroticism; harm avoidance ID FACIAL EXPRESSIONS; VISUAL AWARENESS; SOCIAL ANXIETY; ANGRY FACES; EMOTION; ATTENTION; BIAS; PERSONALITY; DISORDERS; AMYGDALA AB Threatening faces have a privileged status in the brain, which can be reflected in a processing advantage. However, this effect varies among individuals, even healthy adults. For example, one recent study showed that fearful face detection sensitivity correlated with trait anxiety in healthy adults (S. Japee, L. Crocker, F. Carver, L. Pessoa, & L. G. Ungerleider, 2009. Individual differences in valence modulation of face-selective M170 response. Emotion, 9, 59-69). Here, we expanded on those findings by investigating whether intersubject variability in fearful face detection is also associated with state anxiety, as well as more broadly with other traits related to anxiety. To measure fearful face detection sensitivity, we used a masked face paradigm where the target face was presented for only 33 ms and was immediately followed by a neutral face mask. Subjects then rated their confidence in detecting either fear or no fear in the target face. Fearful face detection sensitivity was calculated for each subject using signal detection theory. Replicating previous results, we found a significant positive correlation between trait anxiety and fearful face detection sensitivity. However, this behavioral advantage did not correlate with state anxiety. We also found that fearful face detection sensitivity correlated with other personality measures, including neuroticism and harm avoidance. Our data suggest that fearful face detection sensitivity varies parametrically across the healthy population, is associated broadly with personality traits related to anxiety, but remains largely unaffected by situational fluctuations in anxiety. These results underscore the important contribution of anxiety-related personality traits to threat processing in healthy adults. C1 [Doty, Tracy J.; Japee, Shruti; Ungerleider, Leslie G.] NIMH, Lab Brain & Cognit, Bethesda, MD 20892 USA. [Doty, Tracy J.; Ingvar, Martin] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden. RP Doty, TJ (reprint author), USA, Res Lab, Translat Neurosci Branch, 459 Mulberry Point Rd, Aberdeen, MD 21005 USA. EM tracy.doty@alumni.duke.edu RI Doty, Tracy Jill/J-3962-2012; OI Doty, Tracy/0000-0001-9921-2457; Ingvar, Martin/0000-0002-9041-5714 FU Intramural NIH HHS [Z99 MH999999] NR 34 TC 10 Z9 10 U1 4 U2 23 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 1528-3542 J9 EMOTION JI Emotion PD APR PY 2013 VL 13 IS 2 BP 183 EP 188 DI 10.1037/a0031373 PG 6 WC Psychology, Experimental SC Psychology GA 125FI UT WOS:000317524600002 PM 23398584 ER PT J AU Rafuse, ES AF Rafuse, Ethan S. TI The Leadership of Ulysses S. Grant:A General Who Will Fight SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Rafuse, Ethan S.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. RP Rafuse, ES (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 2 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2013 VL 77 IS 2 BP 706 EP 707 PG 2 WC History SC History GA 120GN UT WOS:000317158900033 ER PT J AU Bourque, SA AF Bourque, Stephen A. TI The Blood of Free Men: The Liberation of Paris, 1944 SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Bourque, Stephen A.] Sch Adv Mil Studies, Ft Leavenworth, KS 66027 USA. RP Bourque, SA (reprint author), Sch Adv Mil Studies, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2013 VL 77 IS 2 BP 747 EP 749 PG 3 WC History SC History GA 120GN UT WOS:000317158900062 ER PT J AU House, JM AF House, Jonathan M. TI State of War: The Political Economy of American Warfare, 1945-2011 SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [House, Jonathan M.] US Army Command, Ft Leavenworth, KS 66027 USA. [House, Jonathan M.] Gen Staff Coll, Ft Leavenworth, KS USA. RP House, JM (reprint author), US Army Command, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2013 VL 77 IS 2 BP 753 EP 754 PG 2 WC History SC History GA 120GN UT WOS:000317158900066 ER PT J AU Grau, LW AF Grau, Lester W. TI War from the Ground Up: Twenty-First Century Combat as Politics SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Grau, Lester W.] Foreign Mil Studies Off, Ft Leavenworth, KS 66027 USA. RP Grau, LW (reprint author), Foreign Mil Studies Off, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2013 VL 77 IS 2 BP 768 EP 769 PG 2 WC History SC History GA 120GN UT WOS:000317158900076 ER PT J AU Huber, T AF Huber, Thomas TI We are always pleased to have letters to the editor because this shows that people are reading our Journal seriously. However, due to space limitations, we ask that letters be kept under 500 words SO JOURNAL OF MILITARY HISTORY LA English DT Letter C1 Gen Staff & Command Coll, Mil Hist Dept, Ft Leavenworth, KS 66027 USA. RP Huber, T (reprint author), Gen Staff & Command Coll, Mil Hist Dept, Ft Leavenworth, KS 66027 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2013 VL 77 IS 2 BP 790 EP 792 PG 3 WC History SC History GA 120GN UT WOS:000317158900082 ER PT J AU Maule, AL Heaton, KJ Rodrigues, E Smith, KW McClean, MD Proctor, SP AF Maule, Alexis L. Heaton, Kristin J. Rodrigues, Ema Smith, Kristen W. McClean, Michael D. Proctor, Susan P. TI Postural Sway and Exposure to Jet Propulsion Fuel 8 Among US Air Force Personnel SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID CLINICAL BALANCE TESTS; TRUNK SWAY; INHALATION EXPOSURE; URINARY BIOMARKERS; SOLVENT EXPOSURE; DERMAL EXPOSURE; WORKERS; JP-8; STABILITY; GAIT AB Objective: To determine whether short-term jet propulsion fuel 8 (JP-8) exposure is associated with balance measurements in JP-8-exposed air force personnel. Methods: As part of a larger neuroepidemiology study, balance tasks were completed by JP-8 exposed individuals (n = 37). Short-term JP-8 exposure was measured using personal breathing zone levels and urinary biomarkers. Multivariate linear regression analyses were conducted to examine the relationship between workday JP-8 exposure and postural sway. Results: Balance control decreased as the task became more challenging. Workday exposure to JP-8, measured by either personal air or urinary metabolite levels, was not significantly related to postural sway. Increases in workday postural sway were associated with demographic variables, including younger age, being a current smoker, and higher body mass index. Conclusion: Results suggest that short-term workday JP-8 exposure does not significantly contribute to diminished balance control. C1 [Maule, Alexis L.; Heaton, Kristin J.; Proctor, Susan P.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. [Heaton, Kristin J.; Proctor, Susan P.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Rodrigues, Ema; Smith, Kristen W.; McClean, Michael D.] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA. [Proctor, Susan P.] VA Boston Healthcare Syst, Boston, MA USA. RP Proctor, SP (reprint author), USA, Mil Performance Div, Environm Med Res Inst, Kansas St,Bldg 42, Natick, MA 01760 USA. EM susan.proctor@us.army.mil RI sebastianovitsch, stepan/G-8507-2013; Heaton, Kristin/E-3660-2013; McClean, Michael/J-2934-2015; OI McClean, Michael/0000-0002-3902-8823 FU US Air Force; US Army Medical Research and Materiel Command/Neurotoxin Exposure Treatment Program [W81XWH-06-1-0105] FX The authors thank the US Air Force personnel for their support and generous participation in the project. They thank the additional Boston area study team personnel (N. Longcore, E. Kryskow, K. Merchant-Borna, H. MacDonald, and A. Graefe) and other personnel from local universities for their assistance in data collection at the respective US Air Force base locations. This work was supported by the US Army Medical Research and Materiel Command/Neurotoxin Exposure Treatment Program though a grant award (W81XWH-06-1-0105; principal investigator: S.P. Proctor) to the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. NR 34 TC 3 Z9 3 U1 1 U2 12 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD APR PY 2013 VL 55 IS 4 BP 446 EP 453 DI 10.1097/JOM.0b013e31827db94b PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 124BT UT WOS:000317439500011 PM 23532195 ER PT J AU Cheppudira, B Greer, A Mares, A Fowler, M Garza, T Petz, L Loyd, D Clifford, J AF Cheppudira, B. Greer, A. Mares, A. Fowler, M. Garza, T. Petz, L. Loyd, D. Clifford, J. TI The anti-inflammatory and analgesic activity of curcumin in a rat model of full thickness thermal injury SO JOURNAL OF PAIN LA English DT Meeting Abstract C1 [Cheppudira, B.; Greer, A.; Mares, A.; Fowler, M.; Garza, T.; Petz, L.; Loyd, D.; Clifford, J.] USA, Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 1 U2 4 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1526-5900 J9 J PAIN JI J. Pain PD APR PY 2013 VL 14 IS 4 SU 1 BP S52 EP S52 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 126RR UT WOS:000317639400207 ER PT J AU Salas, M Hayden, J Petz, L Loyd, D Slater, T Clifford, J Fowler, M AF Salas, M. Hayden, J. Petz, L. Loyd, D. Slater, T. Clifford, J. Fowler, M. TI Resiniferatoxin attenuates pain behaviors in a rat model of mixed thickness thermal injury SO JOURNAL OF PAIN LA English DT Meeting Abstract C1 [Salas, M.; Hayden, J.; Petz, L.; Loyd, D.; Slater, T.; Clifford, J.; Fowler, M.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1526-5900 J9 J PAIN JI J. Pain PD APR PY 2013 VL 14 IS 4 SU 1 BP S49 EP S49 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 126RR UT WOS:000317639400194 ER PT J AU Samokhvalov, IM Tyniankin, NA Reva, VA Rasmussen, TE AF Samokhvalov, Igor M. Tyniankin, Nikolay A. Reva, Viktor A. Rasmussen, Todd E. TI The military surgical legacy of Vladimir Oppel (1872-1932) SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article AB Vladimir A. Oppel (1872-1932) was a forefather of military trauma systems. As a surgeon in the Russian Army in World War I, Oppel experienced the challenges and inefficiencies associated with caring for large numbers of combat wounded, the inefficiencies he observed leading to unacceptable morbidity and mortality. As a consequence, Oppel envisioned a coordinated sequence of surgical care on the battlefield and developed the concept of "targeted evacuation." In his work, Oppel was among the first to propose the "right operation for the right patient at the right location at the right time." Central to Oppel's precepts were (1) the forward positioning of surgical care close to the point of injury, (2) the development of a reserve of proficient and deployable military surgeons, and (3) the provision of specialized surgery to optimize survival and reduce morbidity. Oppel's teachings were validated during World War II in the performance of the Soviet casualty evacuation system and in all modern wars modern since. Today, nearly 100 years after the work of Vladimir Oppel, the benefits of a coordinated or "targeted" trauma system, working to optimize survival after trauma, are well recognized around the world. (J Trauma Acute Care Surg. 2013;74: 1178-1181. Copyright (C) 2013 by Lippincott Williams & Wilkins) C1 [Samokhvalov, Igor M.; Tyniankin, Nikolay A.; Reva, Viktor A.] Russian Mil Med Acad, Russian Dept War Surg, St Petersburg, Russia. [Rasmussen, Todd E.] USA, Inst Surg Res, San Antonio, TX 78236 USA. [Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. RP Rasmussen, TE (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, San Antonio, TX 78236 USA. EM todd.rasmussen@amedd.army.mil RI Reva, Viktor/R-4746-2016; Samokhvalov, Igor/A-1835-2017 OI Reva, Viktor/0000-0001-6705-9849; Samokhvalov, Igor/0000-0003-1398-3467 NR 16 TC 1 Z9 3 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD APR PY 2013 VL 74 IS 4 BP 1178 EP 1181 DI 10.1097/TA.0b013e3182858407 PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 123SS UT WOS:000317411700039 PM 23511163 ER PT J AU Fang, W Hsu, AL Caudillo, R Song, Y Birdwell, AG Zakar, E Kalbac, M Dubey, M Palacios, T Dresselhaus, MS Araujo, PT Kong, J AF Fang, Wenjing Hsu, Allen L. Caudillo, Roman Song, Yi Birdwell, A. Glen Zakar, Eugene Kalbac, Martin Dubey, Madan Palacios, Tomas Dresselhaus, Millie S. Araujo, Paulo T. Kong, Jing TI Rapid Identification of Stacking Orientation in Isotopically Labeled Chemical-Vapor Grown Bilayer Graphene by Raman Spectroscopy SO NANO LETTERS LA English DT Article DE AB-stacked bilayer graphene; carbon isotope; Raman spectroscopy; growth mechanism; fluorination ID FEW-LAYER GRAPHENE; LARGE-AREA; HIGH-QUALITY; FILMS; DEPOSITION; FOILS AB The growth of large-area bilayer graphene has been of technological importance for graphene electronics. The successful application of graphene bilayers critically relies on the precise control of the stacking orientation, which determines both electronic and vibrational properties of the bilayer system. Toward this goal, an effective characterization method is critically needed to allow researchers to easily distinguish the bilayer stacking orientation (i.e., AB stacked or turbostratic). In this work, we developed such a method to provide facile identification of the stacking orientation by isotope labeling. Raman spectroscopy of these isotopically labeled bilayer samples shows a clear signature associated with AB stacking between layers, enabling rapid differentiation between turbostratic and AB-stacked bilayer regions. Using this method, we were able to characterize the stacking orientation in bilayer graphene grown through Low Pressure Chemical Vapor Deposition (LPCVD) with enclosed Cu foils, achieving almost 70% AB-stacked bilayer graphene. Furthermore, by combining surface sensitive fluorination with such hybrid C-12/C-13 bilayer samples, we are able to identify that the second layer grows underneath the first-grown layer, which is similar to a recently reported observation. C1 [Fang, Wenjing; Hsu, Allen L.; Song, Yi; Palacios, Tomas; Dresselhaus, Millie S.; Araujo, Paulo T.; Kong, Jing] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA. [Dresselhaus, Millie S.] MIT, Dept Phys, Cambridge, MA 02139 USA. [Caudillo, Roman] Intel Corp, Components Res, Hillsboro, OR 97124 USA. [Birdwell, A. Glen; Zakar, Eugene; Dubey, Madan] USA, Res Lab, Adelphi, MD 20783 USA. [Kalbac, Martin] Acad Sci Czech Republic, J Heyrovsky Inst Phys Chem, CZ-18223 Prague 8, Czech Republic. RP Kong, J (reprint author), MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA. EM ptaraujo@mit.edu; jingkong@mit.edu RI Kalbac, Martin/F-5129-2014 FU National Science Foundation [NSF DMR 0845358]; Graphene Approaches to Terahertz Electronics (GATE) Multidisciplinary University Research Initiative (MURI) of Massachusetts Institute of Technology (MIT)-Harvard University-Boston University through the Office of Naval Research (ONR); MSD Focus Center; U.S. Army Research Laboratory (ARL); GACR [P208/12/1062]; MSMT [LH13022]; [ONR-MURI-N00014-09-1-1063] FX This work was partially supported by the National Science Foundation under award number NSF DMR 0845358 and the Graphene Approaches to Terahertz Electronics (GATE) Multidisciplinary University Research Initiative (MURI) of Massachusetts Institute of Technology (MIT)-Harvard University-Boston University through the Office of Naval Research (ONR), MSD Focus Center, and U.S. Army Research Laboratory (ARL). P.T.A. and M.S.D. acknowledge ONR-MURI-N00014-09-1-1063. M.K. acknowledges the support from GACR project P208/12/1062. M.K. acknowledges the support from GACR project P208/12/1062 and MSMT (LH13022). NR 42 TC 65 Z9 66 U1 11 U2 156 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 J9 NANO LETT JI Nano Lett. PD APR PY 2013 VL 13 IS 4 BP 1541 EP 1548 DI 10.1021/nl304706j PG 8 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 125OO UT WOS:000317549300029 PM 23470052 ER PT J AU Dowben, JS Grant, JS Froelich, KD Keltner, NL AF Dowben, Jonathan S. Grant, Joan S. Froelich, Kimberly D. Keltner, Norman L. TI Biological Perspectives Hydroxyzine for Anxiety: Another Look at an Old Drug SO PERSPECTIVES IN PSYCHIATRIC CARE LA English DT Article DE Hydroxyzine; anxiety ID GENERALIZED ANXIETY; DISORDER; EFFICACY; PLACEBO C1 [Dowben, Jonathan S.] Brooke Army Med Ctr, Pediat & Adolescent Behav Hlth Serv, San Antonio, TX USA. [Grant, Joan S.; Keltner, Norman L.] Univ Alabama Birmingham, Birmingham, AL 35294 USA. [Froelich, Kimberly D.] Birmingham VA Med Ctr, Patient Care Serv, Birmingham, AL USA. RP Keltner, NL (reprint author), Univ Alabama Birmingham, Birmingham, AL 35294 USA. EM nkeltner@uab.edu OI Grant, Joan/0000-0001-6000-4060 NR 9 TC 4 Z9 4 U1 2 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0031-5990 J9 PERSPECT PSYCHIATR C JI Perspect. Psychiatr. Care PD APR PY 2013 VL 49 IS 2 BP 75 EP 77 DI 10.1111/ppc.12012 PG 3 WC Nursing; Psychiatry SC Nursing; Psychiatry GA 122DE UT WOS:000317295600002 PM 23557449 ER PT J AU Joslyn, S Nemec, L Savelli, S AF Joslyn, Susan Nemec, Lou Savelli, Sonia TI The Benefits and Challenges of Predictive Interval Forecasts and Verification Graphics for End Users SO WEATHER CLIMATE AND SOCIETY LA English DT Article ID WEATHER FORECASTS; PROBABILITY; UNCERTAINTY AB Two behavioral experiments tested the use of predictive interval forecasts and verification graphics by nonexpert end users. Most participants were able to use a simple key to understand a predictive interval graphic, showing a bracket to indicate the upper and lower boundary values of the 80% predictive interval for temperature. In the context of a freeze warning task, the predictive interval forecast narrowed user expectations and alerted participants to the possibility of colder temperatures. As a result, participants using predictive intervals took precautionary action more often than did a control group using deterministic forecasts. Moreover, participants easily understood both deterministic and predictive interval verification graphics, based on simple keys, employing them to correctly identify better performing forecast periods. Importantly, participants with the predictive interval were more likely than those with the deterministic forecast to say they would use that forecast type in the future, demonstrating increased trust. Verification graphics also increased trust in both predictive interval and deterministic forecasts when the effects were isolated from familiarity in the second study. These results suggest that forecasts that include an uncertainty estimate might maintain user trust even when the single-value forecast fails to verify, an effect that may be enhanced by explicit verification data. C1 [Joslyn, Susan; Savelli, Sonia] Univ Washington, Seattle, WA 98195 USA. [Nemec, Lou] US Mil Acad, West Point, NY 10996 USA. RP Joslyn, S (reprint author), Univ Washington, Dept Psychol, POB 351525, Seattle, WA 98195 USA. EM susanj@uw.edu FU National Science Foundation [1023354] FX This material is based upon work supported by the National Science Foundation Grant 1023354. NR 12 TC 4 Z9 4 U1 2 U2 13 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1948-8327 J9 WEATHER CLIM SOC JI Weather Clim. Soc. PD APR PY 2013 VL 5 IS 2 BP 133 EP 147 DI 10.1175/WCAS-D-12-00007.1 PG 15 WC Environmental Studies; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA 125NH UT WOS:000317546000004 ER PT J AU Stanzione, JF Giangiulio, PA Sadler, JM La Scala, JJ Wool, RP AF Stanzione, Joseph F., III Giangiulio, Philip A. Sadler, Joshua M. La Scala, John J. Wool, Richard P. TI Lignin-Based Bio-Oil Mimic as Biobased Resin for Composite Applications SO ACS SUSTAINABLE CHEMISTRY & ENGINEERING LA English DT Article DE Lignin; Renewable resources; Vinyl ester resin; Bio-oil; Styrene replacements/alternatives; Near-IR; TGA; DMA ID VINYL-ESTER RESINS; LIQUID MOLDING RESINS; INFRARED-SPECTROSCOPY; THERMAL-DEGRADATION; MODEL COMPOUNDS; CURE KINETICS; CHEMICALS; ULTRAFILTRATION; FRACTIONATION; VALORIZATION AB Lignin is an abundant renewable raw material that has the potential to yield valuable bio-oils consisting of aromatic chemicals when strategically depolymerized. In order to determine if lignin-based bio-oils can be utilized in the development of biobased vinyl ester resins without the need of extensive and costly separations, a methacrylated lignin-based bio-oil mimic (MBO) was generated and utilized as a low viscosity vinyl ester resin (30.3 cP at 25 degrees C) and as a reactive diluent in a standard commercial vinyl ester resin. MBO was comprised of phenol, guaiacols, and catechols that were methacrylated by esterification with methacrylic anhydride and a catalytic amount of 4-dimethylaminopyridine. Curing the resin produced hard transparent thermosets that possessed near complete conversion of free radical polymerizable groups as per near-infrared spectroscopy. Temperatures of maximum decomposition rate (>= 400 degrees C) and initial decomposition temperatures (>= 300 degrees C) were measured by means of thermo-gravimetric analysis (TGA). Glass transition temperatures >= 115 degrees C and storage moduli >= 2.5 GPa at 25 degrees C were measured by dynamic mechanical analysis (DMA). Overall, high-performance lignin-based thermosets were synthesized possessing comparable thermo-gravimetric and thermo-mechanical properties to commercial petroleum- and vinyl ester-based thermosets. C1 [Stanzione, Joseph F., III; Giangiulio, Philip A.; Wool, Richard P.] Univ Delaware, Dept Chem & Biomol Engn, Newark, DE 19716 USA. [Stanzione, Joseph F., III; Giangiulio, Philip A.; Wool, Richard P.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. [Sadler, Joshua M.; La Scala, John J.] USA, Res Lab, RDRL WMM C, Aberdeen Proving Ground, MD 21005 USA. RP Wool, RP (reprint author), Univ Delaware, Dept Chem & Biomol Engn, Newark, DE 19716 USA. EM wool@udel.edu FU Strategic Environmental Research and Development Program [SERDP WP-1758, W911NF-06-2-001] FX The authors gratefully acknowledge the Strategic Environmental Research and Development Program (SERDP WP-1758) through the Cooperative Agreement W911NF-06-2-001 for financial support. In addition, the authors thank Dr. Thomas H. Epps and Dr. Michael T. Klein of the Chemical & Biomolecular Engineering Department at the University of Delaware for use of his GPC and insightful conversations, respectively. The authors also thank Dr. Michael Mackay of the Materials Science and Engineering Department at the University of Delaware for use of his TGA and DSC. NR 44 TC 27 Z9 27 U1 2 U2 90 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2168-0485 J9 ACS SUSTAIN CHEM ENG JI ACS Sustain. Chem. Eng. PD APR PY 2013 VL 1 IS 4 BP 419 EP 426 DI 10.1021/sc3001492 PG 8 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Chemical SC Chemistry; Science & Technology - Other Topics; Engineering GA 120FN UT WOS:000317156300006 ER PT J AU Theurer, WM Bhavsar, AK AF Theurer, Wesley M. Bhavsar, Amit K. TI Prevention of Unintentional Childhood Injury SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID RISK-FACTORS; RESIDENTIAL FIRES; META-REGRESSION; SAFETY; CHILDREN; HOME; METAANALYSIS; DEATHS; RATES; FALLS AB Unintentional injury accounts for 40 percent of childhood deaths annually, most commonly from motor vehicle crashes. The proper use of child restraints is the most effective strategy to prevent injury or death. Motor vehicle restraint guidelines have recently been revised to an age-based system that delays the progression in type of restraint for most children. Strategies to prevent suffocation in children include using appropriate bedding, positioning babies on their backs to sleep, and removing items from the sleep and play environment that could potentially entrap or entangle the child. Fencing that isolates a swimming pool from the yard and surrounding area and "touch" adult supervision (i.e., an adult is in the water and able to reach and grab a child) have been shown to be most effective in preventing drownings. Swimming lessons are recommended for children older than four years. Poison prevention programs have been shown to improve prevention behavior among caregivers, but may not decrease poisoning incidence. Syrup of ipecac is not recommended. Smoke detector maintenance, a home escape plan, and educating children about how to respond during a fire emergency are effective strategies for preventing fire injuries or death. Fall injuries may be reduced by not using walkers for infants and toddlers or bunk beds for children six years and younger. Consistent helmet use while bicycling reduces head and brain injuries. Although direct counseling by physicians appears to improve some parental safety behaviors, its effect on reducing childhood injuries is uncertain. Community-based interventions can be effective in high-risk populations. (Am Fam Physician. 2013;87(7):502-509. Copyright (c) 2013 American Academy of Family Physicians.) C1 [Theurer, Wesley M.] USA, Madigan Army Med Ctr, Tacoma, WA 98431 USA. [Bhavsar, Amit K.] USA, Tripler Army Med Ctr, Honolulu, HI USA. RP Theurer, WM (reprint author), USA, Madigan Family Med Bldg,9040 Jackson Ave, Tacoma, WA 98431 USA. EM wesley.theurer@amedd.army.mil NR 40 TC 5 Z9 6 U1 2 U2 28 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD APR 1 PY 2013 VL 87 IS 7 BP 502 EP 509 PG 8 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 121QR UT WOS:000317259800007 PM 23547592 ER PT J AU Dumre, SP Shakya, G Na-Bangchang, K Eursitthichai, V Grams, HR Upreti, SR Ghimire, P Khagendra, KC Nisalak, A Gibbons, RV Fernandez, S AF Dumre, Shyam P. Shakya, Geeta Na-Bangchang, Kesara Eursitthichai, Veerachai Grams, Hans Rudi Upreti, Senendra R. Ghimire, Prakash Khagendra, K. C. Nisalak, Ananda Gibbons, Robert V. Fernandez, Stefan TI Short Report: Dengue Virus and Japanese Encephalitis Virus Epidemiological Shifts in Nepal: A Case of Opposing Trends SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID IMMUNIZATION; VACCINE; CHILDREN AB We report on the changing epidemiology of two important flaviviruses in Nepal: Japanese encephalitis (JE) and dengue viruses. Morbidity and mortality in Nepal is in the thousands since JE was introduced in 1978. Nepal launched an extensive laboratory-based JE surveillance in 2004. Nepal experienced a remarkable reduction in disease burden after mass immunizations from 2005 to 2010, when 2,040 JE infections and 205 JE-related deaths were confirmed. With its emergence in 2006, dengue has become a significant challenge in the country, highlighted by a sudden outbreak in 2010 that resulted in 359 confirmed dengue infections. Currently, both viruses cocirculate in Nepal. Here, we document the remarkable expansion of dengue in Nepal, which urgently requires national surveillance to refine the burden and make recommendations regarding control and prevention programs. We believe that the use of existing JE surveillance network for integrated dengue surveillance may represent the most appropriate alternative. C1 [Dumre, Shyam P.; Na-Bangchang, Kesara; Eursitthichai, Veerachai; Grams, Hans Rudi] Thammasat Univ, Fac Allied Hlth Sci, Pathum Thani, Thailand. [Shakya, Geeta; Khagendra, K. C.] Minist Hlth & Populat, Natl Publ Hlth Lab, Kathmandu, Nepal. [Upreti, Senendra R.] Minist Hlth & Populat, Kathmandu, Nepal. [Ghimire, Prakash] Tribhuwan Univ, Cent Dept Microbiol, Kathmandu, Nepal. [Nisalak, Ananda; Gibbons, Robert V.; Fernandez, Stefan] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Fernandez, S (reprint author), USAMC AFRIMS, APO, AP 96546 USA. EM shyamprad@hotmail.com; nphl@wlink.com.np; kesaratmu@yahoo.com; veebkk@gmail.com; rgrams@alfa.ac.th; senendraupreti933@hotmail.com; prakashghimire@yahoo.com; khaggu17@hotmail.com; anandan@afrims.org; robert.gibbons@afrims.org; stefan.fernandez@afrims.org FU World Health Organization-Special Program for Research and Training in Topical Diseases, Geneva, Switzerland Leadership Training Grant [A80350] FX The dengue component of this study was partly supported by World Health Organization-Special Program for Research and Training in Topical Diseases, Geneva, Switzerland Leadership Training Grant A80350 (to S.P.D.). NR 20 TC 12 Z9 12 U1 0 U2 13 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 2013 VL 88 IS 4 BP 677 EP 680 DI 10.4269/ajtmh.12-0436 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 118KP UT WOS:000317024700012 PM 23419366 ER PT J AU Guicheteau, JA Farrell, ME Christesen, SD Fountain, AW Pellegrino, PM Emmons, ED Tripathi, A Wilcox, P Emge, D AF Guicheteau, Jason A. Farrell, Mikella E. Christesen, Steven D. Fountain, Augustus W., III Pellegrino, Paul M. Emmons, Erik D. Tripathi, Ashish Wilcox, Phillip Emge, Darren TI Surface-Enhanced Raman Scattering (SERS) Evaluation Protocol for Nanometallic Surfaces SO APPLIED SPECTROSCOPY LA English DT Article DE Surface-enhanced Raman scattering; SERS; Raman; Enhancement factor; Receiver operator curve ID SILVER ELECTRODE; LARGE-AREA; SPECTROSCOPY; NANOPARTICLES; PYRIDINE; SPECTRA; SENSORS; ARRAYS; MODEL AB We present the results of a three-year collaboration between the U.S. Army Edgewood Chemical Biological Center and the U.S. Army Research Laboratory-Aldelphi Laboratory Center on the evaluation of selected nanometallic surfaces developed for the Defense Advanced Research Projects Agency Surface-Enhanced Raman Scattering (SERS) Science and Technology Fundamentals program. The primary role of the two Army labs was to develop the analytical and spectroscopic figures of merit to unambiguously compare the sensitivity and reproducibility of various SERS substrates submitted by the program participants. We present the design and implementation of an evaluation protocol for SERS active surfaces enabling an enhancement value calculation from which different substrates can be directly compared. This method was established to: (1) collect physical and spectral characterization data from the small number of substrates (performer supplied) typically encountered, and (2) account for the complex fabrication technique and varying nature of the substrate platforms encountered within this program. C1 [Guicheteau, Jason A.; Christesen, Steven D.; Fountain, Augustus W., III; Wilcox, Phillip; Emge, Darren] Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA. [Farrell, Mikella E.; Pellegrino, Paul M.] USA, Res Lab, Adelphi Lab Ctr, Adelphi, MD 20783 USA. [Emmons, Erik D.; Tripathi, Ashish] Sci Applicat Int Corp, Aberdeen Proving Ground, MD 21010 USA. RP Fountain, AW (reprint author), Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA. EM augustus.w.fountain.civ@mail.mil FU DARPA under the SERS S&T Fundamentals program; National Research Council Research associateship award at the U.S. Army Edgewood Chemical Biological Center FX This research was funded by DARPA under the SERS S&T Fundamentals program. We thank Dennis Polla (DARPA) and Michael Bobrilc (System Planning Corp.) for support during the Army labs participation as well as Tracey Hamilton (U.S. Army Medical Research Institute of Chemical Defense). Finally, we thank all the DARPA participants for providing the collaborating Army labs with the substrates and information needed to perform their role in the program. This research was performed while Erik D. Emmons held a National Research Council Research associateship award at the U.S. Army Edgewood Chemical Biological Center. The opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Government. NR 54 TC 9 Z9 9 U1 0 U2 48 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA 5320 SPECTRUM DRIVE SUITE C, FREDERICK, MD 21703 USA SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD APR PY 2013 VL 67 IS 4 BP 396 EP 403 DI 10.1366/12-06846 PG 8 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA 120KB UT WOS:000317168100009 PM 23601539 ER PT J AU Larue, EA Zuellig, MP Netherland, MD Heilman, MA Thum, RA AF LaRue, Elizabeth A. Zuellig, Matthew P. Netherland, Michael D. Heilman, Mark A. Thum, Ryan A. TI Hybrid watermilfoil lineages are more invasive and less sensitive to a commonly used herbicide than their exotic parent (Eurasian watermilfoil) SO EVOLUTIONARY APPLICATIONS LA English DT Article DE biological invasion; contemporary evolution; herbicide resistance; heterosis; hybridization; Myriophyllum spicatum ID HYBRIDIZATION; POPULATIONS; EVOLUTION; HABITATS; PLANTS AB Hybridization may stimulate the evolution of invasiveness in human-impacted habitats if unique hybrid genotypes have higher fitness than parental genotypes. Human efforts to control invasive taxa frequently involve the intentional alteration of habitats, but few studies have considered whether hybridization can result in decreased sensitivity to control measures. Here, we investigate whether interspecific hybrids between introduced Eurasian watermilfoil (Myriophyllum spicatum) and native northern watermilfoil (M.sibiricum) are more invasive than parental Eurasian watermilfoil, especially in regard to their relative responses to an herbicide commonly applied for their control (2,4-dichlorophenoxyacetic acid; 2,4-D). In two separate laboratory experiments, hybrids on average grew faster and were less sensitive to 2,4-D compared with parental Eurasian watermilfoil. These two invasive traits appear to be common in hybrid watermilfoils, as opposed to being restricted to a few unique lineages, because they were found in a diversity of hybrid genotypes from several independent hybridization events. In addition, we found that hybrids occurred more frequently than parental species in natural lakes previously treated with 2,4-D. Our results provide compelling empirical evidence that hybridization is associated with the evolution of increased invasiveness in watermilfoils, and have important implications for their management. C1 [LaRue, Elizabeth A.; Zuellig, Matthew P.; Thum, Ryan A.] Grand Valley State Univ, Annis Water Resources Inst, Muskegon, MI 49441 USA. [Netherland, Michael D.] USA, Ctr Aquat & Invas Plants, Engn Res & Dev Ctr, Gainesville, FL USA. [Heilman, Mark A.] SePRO Corp, Carmel, IN USA. RP Larue, EA (reprint author), Grand Valley State Univ, Annis Water Resources Inst, 740 W Shoreline Dr, Muskegon, MI 49441 USA. EM laruee@mail.gvsu.edu; thumr@gvsu.edu FU National Science Foundation [DEB-0318553]; We Energies; Michigan Space Grant Consortium; Midwest Aquatic Plant Management Society; West Michigan Air and Waste Management Association; Grand Valley State University FX Thanks to A. Hruska, D. Wcisel, H. Hayward, and B. Sikkenga for assistance with sampling and laboratory work. J. McNair provided statistical advice on the distribution patterns. Discussions with T. Evans, M. Henshaw, J. Winther, and graduate students at GVSU improved the study. A. Russell, M. Luttenton, A. Snow, N. MacDonald, and H. Tavalire provided helpful comments that improved the initial draft of this manuscript. A. Hendry and two anonymous reviewers greatly improved the manuscript. Funding for this project was provided by the National Science Foundation to RAT (DEB-0318553), We Energies, Michigan Space Grant Consortium, Midwest Aquatic Plant Management Society, West Michigan Air and Waste Management Association, and Grand Valley State University. NR 21 TC 13 Z9 13 U1 6 U2 32 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1752-4571 J9 EVOL APPL JI Evol. Appl. PD APR PY 2013 VL 6 IS 3 BP 462 EP 471 DI 10.1111/eva.12027 PG 10 WC Evolutionary Biology SC Evolutionary Biology GA 117MO UT WOS:000316957800006 PM 23745138 ER PT J AU Rodriguez, RI Ibitayo, D Quintero, PO AF Rodriguez, Rogie I. Ibitayo, Dimeji Quintero, Pedro O. TI Thermal Stability Characterization of the Au-Sn Bonding for High-Temperature Applications SO IEEE TRANSACTIONS ON COMPONENTS PACKAGING AND MANUFACTURING TECHNOLOGY LA English DT Article DE Fluxless; hermetic packages; isothermal solidification; jet vapor deposition (JVD); lead-free; shear strength; SLID; solder; transient liquid phase (TLP) bonding ID PHASE; TECHNOLOGIES; RELIABILITY; KINETICS; JOINTS AB There is a need for electromechanical devices capable of operating in high-temperature environments (> 200 degrees C) for a wide variety of applications. Today's wide-bandgap semiconductor-based power electronics have demonstrated a potential of operating above 400 degrees C, however, they are still limited by packaging. Among the most promising alternatives is the Au-Sn eutectic solder, which has been widely used due to its excellent mechanical and thermal properties. However, the operating temperature of this metallurgical system is still limited to similar to 250 degrees C owing to its melting temperature of 280 degrees C. Therefore, a high-temperature-resistant system is much needed, but without affecting the current processing temperature of similar to 325 degrees C, typically exhibited in most high-temperature Pb-free solders. In this paper, we present the development and characterization of a fluxless die-attach soldering process based on gold-enriched solid-liquid interdiffusion (SLID). A low-melting-point material (eutectic Au-Sn) is deposited in the face of a substrate, whereas a high-melting-point material, gold in this instance, is deposited in its mating substrate. Deposition of all materials was performed using a jet vapor deposition (JVD) equipment where thicknesses are controlled to achieve specific compositions in the mixture. Sandwiched coupons are isothermally processed in a vacuum reflow furnace for different reflow times. Postprocessed samples confirm the interdiffusion mechanism as evidenced by the formation of sound joints that prove to be thermally stable up to similar to 490 degrees C after the completion of the SLID process. Differential scanning calorimetry demonstrate the progression of the SLID process by quantifying the remaining low-melting-point constituent as a function of time and temperature, this serving as an indicator of the completion of the soldering process. Mechanical testing reveals a joint with shear strength varying from 39 to 45.5 MPa, demonstrating to be stable even after 500 h of isothermal aging. Moreover, these investigations successfully demonstrate the use of the Au-Sn SLID system and the JVD technology as potential manufacturing processes and as a lead-free die-attach technology. C1 [Rodriguez, Rogie I.; Quintero, Pedro O.] Univ Puerto Rico, Dept Mech Engn, Mayaguez, PR 00681 USA. [Ibitayo, Dimeji] USA, Res Lab, Adelphi, MD 20783 USA. RP Rodriguez, RI (reprint author), Univ Puerto Rico, Dept Mech Engn, Mayaguez, PR 00681 USA. EM rogie.rodriguez@upr.edu; dimeji.ibitayo@us.army.mil; pedro.quintero@upr.edu FU U.S. Army Research Laboratory Collaborative [W911NF-11-2-0062] FX This work was supported by the U.S. Army Research Laboratory Collaborative under Agreement W911NF-11-2-0062. Recommended for publication by Associate Editor M. Bakir upon evaluation of reviewers' comments. NR 32 TC 9 Z9 10 U1 5 U2 56 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 2156-3950 J9 IEEE T COMP PACK MAN JI IEEE Trans. Compon. Pack. Manuf. Technol. PD APR PY 2013 VL 3 IS 4 BP 549 EP 557 DI 10.1109/TCPMT.2013.2243205 PG 9 WC Engineering, Manufacturing; Engineering, Electrical & Electronic; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 120RS UT WOS:000317190200003 ER PT J AU Vig, J Kim, Y AF Vig, John Kim, Yoonkee TI The Low-Power Potential of Oven-Controlled MEMS Oscillators SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article AB It is shown that oven-controlled micro electromechanical systems (MEMS) oscillators have the potential of attaining a higher frequency stability, with a lower power consumption, than temperature-compensated crystal oscillators (TCXOs) and the currently manufactured MEMS oscillators. C1 [Kim, Yoonkee] USA, Posit Nav & Timing Branch, CERDEC, Aberdeen, MD USA. EM j.vig@ieee.org OI Vig, John/0000-0002-2378-0113 NR 26 TC 5 Z9 5 U1 2 U2 11 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0885-3010 EI 1525-8955 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD APR PY 2013 VL 60 IS 4 BP 851 EP 853 DI 10.1109/TUFFC.2013.2634 PG 3 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA 118FU UT WOS:000317010200022 PM 23549546 ER PT J AU Gade, DM Wilkins, VM AF Gade, Daniel M. Wilkins, Vicky M. TI Where Did You Serve? Veteran Identity, Representative Bureaucracy, and Vocational Rehabilitation SO JOURNAL OF PUBLIC ADMINISTRATION RESEARCH AND THEORY LA English DT Article ID ACTIVE REPRESENTATION; SOCIAL IDENTITY; GENDER; COUNSELOR; WAR; AGENCIES; IMPACT AB The research on representative bureaucracy investigates whether higher levels of representation within public agencies affect policy outcomes. We expand this line of inquiry by examining the effect of symbolic representation on the clients' perceptions of the vocational rehabilitation program administered by the Department of Veterans Affairs. We test the link between passive representation and symbolic representation for Veteran identity. This is one of the first studies to investigate an identity not associated with immutable characteristics. We question how an identity related to a profession that an individual selects into, like Veteran status, can influence a client's relationship with a government program. We find that Veteran clients of the vocational rehabilitation system perceive substantial differences in the behaviors of their counselor and report significantly higher levels of overall satisfaction with the program when they know or believe their counselor is also a Veteran. C1 [Gade, Daniel M.] US Mil Acad, Washington, DC USA. [Wilkins, Vicky M.] Univ Georgia, Athens, GA 30602 USA. RP Gade, DM (reprint author), US Mil Acad, Washington, DC USA. EM daniel.gade@usma.edu NR 47 TC 13 Z9 13 U1 0 U2 7 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1053-1858 J9 J PUBL ADM RES THEOR JI J. Publ. Adm. Res. Theory PD APR PY 2013 VL 23 IS 2 BP 267 EP 288 DI 10.1093/jopart/mus030 PG 22 WC Public Administration SC Public Administration GA 120FB UT WOS:000317155100003 ER PT J AU Carlson, TL Lee, KW Pierce, LM AF Carlson, Terri L. Lee, Karen W. Pierce, Lisa M. TI Effect of Cross-Linked and Non-Cross-Linked Acellular Dermal Matrices on the Expression of Mediators Involved in Wound Healing and Matrix Remodeling SO PLASTIC AND RECONSTRUCTIVE SURGERY LA English DT Article ID VENTRAL HERNIA REPAIR; ABDOMINAL-WALL RECONSTRUCTION; FOREIGN-BODY REACTION; MESH MATERIALS; BIOLOGIC PROSTHESES; PORCINE MODEL; RAT MODEL; METALLOPROTEINASES; INFLAMMATION AB Background: Molecular mechanisms that direct the extent of the foreign body reaction to implanted biological meshes and their subsequent incorporation are poorly understood. The purpose of this study was to compare the influence of non-cross-linked human dermis (AlloDerm) with that of cross-linked porcine dermis (Permacol) on the expression of genes critical for wound healing and tissue remodeling in a rat ventral hernia model. Methods: Full-thickness abdominal wall defects were repaired with AlloDerm, Permacol, or suture repair with no mesh (n = 10 rats per group). Explants were harvested 90 days after repair and divided for histologic, immunohistochemical, and gene expression analyses. Real-time quantitative polymerase chain reaction arrays were used to profile the expression of 84 wound healing-associated genes at the tissue/mesh interface. Results: Both meshes induced the differential expression (>= 3-fold change relative to suture repair, p <= 0.01) of extracellular matrix components, remodeling enzymes, and inflammatory cytokines. Genes most markedly up-regulated included matrix metalloproteinase-9 (Permacol, 66-fold; AlloDerm, 19-fold) and chemokine (C-C motif) ligand 12 (Permacol, 24-fold; AlloDerm, 71-fold). Immunohistochemistry using antibodies against matrix metalloproteinase-9 and chemokine (C-C motif) ligand 12 confirmed differential expression at the protein level (p < 0.001). Histologically, AlloDerm demonstrated overall better remodeling characteristics than Permacol. Conclusions: Permacol elicits increased protease expression and reduced cellular and vascular infiltration compared with AlloDerm 90 days after implantation, indicative of delayed remodeling induced by cross-linking. Increased understanding of the host response to implanted materials ultimately will enable the development of improved meshes with enhanced wound healing properties and fewer graft-related complications. (Plast. Reconstr. Surg. 131: 697, 2013.) C1 Tripler Army Med Ctr, Dept Gen Surg, Honolulu, HI 96859 USA. [Pierce, Lisa M.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. RP Pierce, LM (reprint author), Tripler Army Med Ctr, Dept Clin Invest, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM lisa.pierce@amedd.army.mil FU Victoria S. and Bradley L. Geist Foundation FX This research was funded by a Victoria S. and Bradley L. Geist Foundation grant awarded to Lisa M. Pierce, D.Sc. NR 29 TC 10 Z9 11 U1 1 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0032-1052 J9 PLAST RECONSTR SURG JI Plast. Reconstr. Surg. PD APR PY 2013 VL 131 IS 4 BP 697 EP 705 DI 10.1097/PRS.0b013e3182818a3d PG 9 WC Surgery SC Surgery GA 121YW UT WOS:000317282800047 PM 23249980 ER PT J AU Britzke, ER Gillam, EH Murray, KL AF Britzke, E. R. Gillam, E. H. Murray, K. L. TI Current state of understanding of ultrasonic detectors for the study of bat ecology SO ACTA THERIOLOGICA LA English DT Review DE Acoustic identification; Bat activity; Echolocation; Sampling design; Ultrasonic detectors ID WHITE-NOSE SYNDROME; ECHOLOCATION CALLS; ACOUSTIC IDENTIFICATION; INDIVIDUAL IDENTITY; LASIURUS-CINEREUS; MYOTIS-LUCIFUGUS; PIPISTRELLE BATS; FOREST STRUCTURE; BROWN BATS; HABITAT AB Ultrasonic detectors have become a mainstay for studying the ecology of bats throughout the world. Despite their enormous utility to address a wide variety of research and management issues, many factors that impact the applicability of collected data for answering desired questions are often ignored. Here, we review our current understanding of the utility of ultrasonic detectors for the study of bat ecology and highlight areas where additional work should be done. We gleaned information from published studies, as well as from field research experience, and discuss areas that are in need of further research. We highlight topics such as sampling design and how it can impact results, metrics used to quantify bat activity, and identifying bats with acoustic data including how accuracy rates can be maximized. We also provide research questions that when answered will greatly improve the applicability of future studies. C1 [Britzke, E. R.] USA, Engineer Res & Dev Ctr, Vicksburg, MS USA. [Gillam, E. H.] N Dakota State Univ, Dept Biol Sci, Fargo, ND 58105 USA. [Murray, K. L.] Western EcoSyst Technol Inc, Bloomington, IN USA. RP Britzke, ER (reprint author), USA, Engineer Res & Dev Ctr, Vicksburg, MS USA. EM Eric.R.Britzke@usace.army.mil NR 58 TC 9 Z9 9 U1 12 U2 143 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0001-7051 J9 ACTA THERIOL JI Acta Theriol. PD APR PY 2013 VL 58 IS 2 BP 109 EP 117 DI 10.1007/s13364-013-0131-3 PG 9 WC Zoology SC Zoology GA 113PB UT WOS:000316678900003 ER PT J AU Glaz, B Friedmann, PP Liu, L Cajigas, JG Bain, J Sankar, LN AF Glaz, Bryan Friedmann, Peretz P. Liu, Li Cajigas, Juan G. Bain, Jeremy Sankar, Lakshmi N. TI Reduced-Order Dynamic Stall Modeling with Swept Flow Effects Using a Surrogate-Based Recurrence Framework SO AIAA JOURNAL LA English DT Article ID VOLTERRA THEORY; SYSTEMS; OPTIMIZATION; PREDICTION; PROGRESS AB The extension of the surrogate-based recurrence framework approach to account for time-varying swept flow effects under dynamic stall conditions is described. Using full-order solutions generated by the OVERFLOW computational fluid dynamics code, the surrogate-based recurrence framework reduced-order modeling approach is shown to effectively mimic full-order solutions of unsteady lift, moment, and drag under dynamic stall conditions while maintaining the computational efficiency associated with semiempirical dynamic stall models. This level of functionality represents a new capability for rotary-wing aeroelasticity applications. Furthermore, a generalized kriging formulation based on nonstationary Gaussian process modeling is implemented in a tractable manner by locally optimizing the high-dimensional likelihood function in the vicinity of the stationary solution. The resulting nonstationary covariance structures are shown to significantly improve the accuracy of the surrogate-based recurrence framework predicted moment stall characteristics compared to a stationary model. It is shown that the nonstationary surrogate-based recurrence framework approach is better able to adapt to abrupt changes in airload behavior caused by the underlying dynamic stall vortex dynamics. The results indicate that the surrogate-based recurrence framework approach based on nonstationary Gaussian process models is a promising alternative to widely used semiempirical rotorcraft dynamic stall models that cannot account for the effects of time-varying velocity components associated with forward flight. C1 [Glaz, Bryan] USA, Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. [Friedmann, Peretz P.] Univ Michigan, Dept Aerosp Engn, Ann Arbor, MI 48109 USA. [Liu, Li] Univ Michigan, Ann Arbor, MI 48109 USA. [Cajigas, Juan G.; Bain, Jeremy] Georgia Inst Technol, Atlanta, GA 30332 USA. [Sankar, Lakshmi N.] Georgia Inst Technol, Daniel Guggenheim Sch Aerosp Engn, Atlanta, GA 30332 USA. RP Glaz, B (reprint author), USA, Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. FU Center for Rotorcraft Innovation [WBS 2010-B-1-431-A17]; Vertical Lift Research Center of Excellence (VLRCOE); National Rotorcraft Technology Center (NRTC) FX Partial support from the Center for Rotorcraft Innovation under no. WBS 2010-B-1-431-A17, as well as the Vertical Lift Research Center of Excellence (VLRCOE) sponsored by the National Rotorcraft Technology Center (NRTC) with M. Rutkowski as grant monitor is also acknowledged. NR 36 TC 4 Z9 6 U1 1 U2 16 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0001-1452 J9 AIAA J JI AIAA J. PD APR PY 2013 VL 51 IS 4 BP 910 EP 921 DI 10.2514/1.J051817 PG 12 WC Engineering, Aerospace SC Engineering GA 115QP UT WOS:000316827300013 ER PT J AU De Ausen, L DeFreitas, EF Littleton, L Lustik, M AF De Ausen, Lorena DeFreitas, Erik F. Littleton, Latisha Lustik, Michael TI Leakage from closed-system transfer devices as detected by a radioactive tracer SO AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY LA English DT Article ID DRUG TRANSFER DEVICE; SURFACE CONTAMINATION; ANTINEOPLASTIC DRUGS; WORKPLACE CONTAMINATION; CYCLOPHOSPHAMIDE; EXPOSURE; IFOSFAMIDE; CANCER; AGENTS; SPILL AB Purpose. A study of leakage from selected closed-system transfer devices (CSTDs) under experimental conditions is described. Methods. Three CSTDs (the ChemoClave, On Guard, and PhaSeal systems) were tested. Nine manufacturer-trained oncology pharmacists and pharmacy technicians volunteered to participate in an experiment to determine the degree of leakage of a liquid test agent (a. radioactive technetium isotope [Tc-99m] diluted in normal saline) during CSTD-assisted transfer of liquid from vials to syringes per standard practices. After such transfers, alcohol prep pads (n = 135 for each system) were used to wipe CSTD points of entry and assessed for the presence of Tc-99m. Comparisons among participants and devices were conducted via analysis of variance (ANOVA), with the a priori level of significance set at 0.05. Results. ANOVA results indicated significant differences among devices in leakage of the test solution, with the PhaSeal device having the lowest geometric mean leakage (0.1 nL; 95% confidence interval [CI], 0-0.2 nL), followed by the OnGuard (1.5 nL;. 95% CI, 1.1-1.9 nL) and ChemoClave (35.6 nL; 95% CI, 29.1-43.6 nL) devices; each pairwise comparison was significant (p < 0.001). Despite several major limitations, the research supports the use of CSTDs to help protect health care workers, as recommended by federal authorities and professional groups including the American Society of Health-System Pharmacists. Conclusion. The volume of leakage was significantly less with PhaSeal than with OnGuard and ChemoClave when pharmacists and pharmacy technicians used the three CSTDs and Tc-99m as a tracer. Am J Health-Syst Pharm. 2013; 70:619-23 C1 [De Ausen, Lorena; DeFreitas, Erik F.; Littleton, Latisha] Tripler Army Med Ctr, Dept Pharm, Honolulu, HI 96859 USA. [Littleton, Latisha] 168th Multifunct Med Battal, Taegu, South Korea. RP DeFreitas, EF (reprint author), 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM erik.defreitas@us.army.mil FU Department of Pharmacy, Tripler Army Medical Center; Department of Pharmacy FX Funded by the Department of Pharmacy, Tripler Army Medical Center. All devices were purchased using funds from the Department of Pharmacy. Proprietary information or results of ongoing research may be subject to different interpretations. Investigators agree to abide by the noncommercialism guidelines. NR 20 TC 2 Z9 3 U1 1 U2 5 PU AMER SOC HEALTH-SYSTEM PHARMACISTS PI BETHESDA PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 USA SN 1079-2082 J9 AM J HEALTH-SYST PH JI Am. J. Health-Syst. Pharm. PD APR 1 PY 2013 VL 70 IS 7 BP 619 EP 623 DI 10.2146/ajhp110678 PG 5 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 115UP UT WOS:000316837700015 PM 23515515 ER PT J AU Vojta, D Koehler, TB Longjohn, M Lever, JA Caputo, NF AF Vojta, Deneen Koehler, Timothy B. Longjohn, Matt Lever, Jonathan A. Caputo, Nadine F. TI A Coordinated National Model for Diabetes Prevention Linking Health Systems to an Evidence-Based Community Program SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID INTERVENTIONS; REDUCTION; COSTS; US AB Background: Twenty-six million U.S. adults have diabetes, and 79 million have prediabetes. A2002 Diabetes Prevention Program research study proved the effectiveness of a lifestyle intervention that yielded a 58% reduction in conversion to type 2 diabetes. However, cost per participant was high, complicating efforts to scale up the program. Purpose: UnitedHealth Group (UHG) and the YMCA of the USA, in collaboration with the CDC, sought to develop the infrastructure and business case to scale the congressionally authorized National Diabetes Prevention Program nationwide. Emphasis was placed on developing a model that maintained fidelity to the original 2002 Diabetes Prevention Program research study and could be deployed for a lower cost per participant while yielding similar outcomes. Design: The UHG created the business case and technical and operational infrastructure necessary for nationwide dissemination of the YMCA's Diabetes Prevention Program (YMCA's DPP), as part of the National Diabetes Prevention Program. The YMCA's DPP is a group-based model of 16 core sessions with monthly follow-up delivered by trained lifestyle coaches. Setting/participants: A variety of mechanisms were used to identify, screen, and encourage enrollment for people with prediabetes into the YMCA's DPP. Intervention: Substantial investments were made in relationship building, business planning, technology, development, and operational design to deliver an effective and affordable 12-month program. The program intervention was conducted July 2010-December 2011. Data were collected on the participants over a 15-month period between September 2010 and December 2011. Data were analyzed in February 2012. Main outcome measures: The main outcome measures were infrastructure (communities involved and personnel trained); engagement (screening and enrollment of people with prediabetes); program outcomes (attendance and weight loss); and service delivery cost of the intervention. Results: In less than 2 years, the YMCA's DPP was effectively scaled to 46 communities in 23 states. More than 500 YMCA Lifestyle Coaches were trained. The program enrolled 2369 participants, and 1723 participants completed the core program at an average service-delivery cost of about $400 each. For those individuals completing the program, average weight loss was about 5%. UHG anticipates that within 3 years, savings from reduced medical spending will outweigh initial costs. Conclusions: Large-scale prevention efforts can be scalable and sustainable with collaboration, health information technology, community-based delivery of evidence-based interventions, and novel payment structures that incentivize efficiency and outcomes linked to better health and lower future costs. (Am J Prev Med 2013;44(4S4):S301-S306) (C) 2013 American Journal of Preventive Medicine C1 [Vojta, Deneen; Caputo, Nadine F.] United Hlth Grp, UnitedHlth Ctr Hlth Reform & Modernizat, Minnetonka, MN 55343 USA. [Vojta, Deneen; Koehler, Timothy B.] United Hlth Grp, Diabet Prevent & Control Alliance, Minnetonka, MN USA. [Longjohn, Matt] USA, Chron Dis Prevent Programs, YMCA, Chicago, IL USA. [Longjohn, Matt] Northwestern Univ, Dept Pediat, Feinberg Sch Med, Chicago, IL 60611 USA. [Longjohn, Matt] Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA. [Lever, Jonathan A.] USA, YMCA, Innovat Dept, Washington, DC 20310 USA. RP Vojta, D (reprint author), UnitedHlth Grp, Ctr Hlth Reform & Modernizat, 9900 Bren Rd E,MN008-T830, Minnetonka, MN 55343 USA. EM deneen_vojta@uhg.com FU CDC, Division of Diabetes Translation FX Support for this work was provided to the YMCA of the USA by the CDC, Division of Diabetes Translation. The authors thank Ann Albright, CDC, for her helpful comments. NR 20 TC 23 Z9 24 U1 0 U2 16 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD APR PY 2013 VL 44 IS 4 SU 4 BP S301 EP S306 DI 10.1016/j.amepre.2012.12.018 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 113NH UT WOS:000316674200003 PM 23498291 ER PT J AU Kirk, H Myers, PC Bourke, TL Gutermuth, RA Hedden, A Wilson, GW AF Kirk, Helen Myers, Philip C. Bourke, Tyler L. Gutermuth, Robert A. Hedden, Abigail Wilson, Grant W. TI FILAMENTARY ACCRETION FLOWS IN THE EMBEDDED SERPENS SOUTH PROTOCLUSTER SO ASTROPHYSICAL JOURNAL LA English DT Article DE stars: formation; ISM: clouds; ISM: kinematics and dynamics; ISM: molecules ID STAR-FORMING CORES; MOLECULAR CLOUDS; DENSE CORES; DARK CLOUDS; HYPERFINE-STRUCTURE; STELLAR CLUSTERS; PERSEUS; HCN; MM; SPECTROSCOPY AB One puzzle in understanding how stars form in clusters is the source of mass-is all of the mass in place before the first stars are born, or is there an extended period when the cluster accretes material which can continuously fuel the star formation process? We use a multi-line spectral survey of the southern filament associated with the Serpens South embedded cluster-forming region in order to determine if mass is accreting from the filament onto the cluster, and whether the accretion rate is significant. Our analysis suggests that material is flowing along the filament's long axis at a rate of similar to 30 M-circle dot Myr(-1) (inferred from the N2H+ velocity gradient along the filament), and radially contracting onto the filament at similar to 130 M-circle dot Myr(-1) (inferred from HNC self-absorption). These accretion rates are sufficient to supply mass to the central cluster at a similar rate to the current star formation rate in the cluster. Filamentary accretion flows may therefore be very important in the ongoing evolution of this cluster. C1 [Kirk, Helen; Myers, Philip C.; Bourke, Tyler L.] Harvard Smithsonian Ctr Astrophys, Radio & Geoastron Div, Cambridge, MA 02138 USA. [Gutermuth, Robert A.; Wilson, Grant W.] Univ Massachusetts, Dept Astron, Amherst, MA 01003 USA. [Hedden, Abigail] USA, Res Labs, Adelphi, MD 20783 USA. RP Kirk, H (reprint author), McMaster Univ, Origins Inst, Hamilton, ON L8S 4L8, Canada. EM kirkh@mcmaster.ca FU Smithsonian Scholarly Studies Program grant; National Science Foundation [0708158] FX We thank the referee for suggestions which helped to clarify aspects of this paper. We thank Steve Longmore for assistance with the Mopra observing setup and data reduction. We thank Phil Edwards at ATNF for allocating additional time to complete our Mopra observations, and all the ATNF Narrabri staff for their support. We thank Rachel Friesen for sending her ammonia temperature results prior to publication, and for several interesting discussions on Serpens South. We thank Elaine Winston and Scott Wolk for sharing the results of their Chandra survey of Serpens South prior to publication. H.K. thanks Paola Caselli for a valuable discussion on astrochemistry, Chris de Vries for answering queries on his infall fitter on numerous occasions, and Fabian Heitsch for a critical read-through of an earlier draft of this paper, as well as sending a copy of his filamentary accretion paper pre-publication. H.K. acknowledges funding from a Smithsonian Scholarly Studies Program grant. This research was supported in part by the National Science Foundation under grant number 0708158 (T.L.B.). NR 62 TC 64 Z9 64 U1 0 U2 3 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0004-637X J9 ASTROPHYS J JI Astrophys. J. PD APR 1 PY 2013 VL 766 IS 2 AR 115 DI 10.1088/0004-637X/766/2/115 PG 14 WC Astronomy & Astrophysics SC Astronomy & Astrophysics GA 108UE UT WOS:000316320900049 ER PT J AU Corona, BT Wu, XW Ward, CL McDaniel, JS Rathbone, CR Walters, TJ AF Corona, Benjamin T. Wu, Xiaowu Ward, Catherine L. McDaniel, Jennifer S. Rathbone, Christopher R. Walters, Thomas J. TI The promotion of a functional fibrosis in skeletal muscle with volumetric muscle loss injury following the transplantation of muscle-ECM SO BIOMATERIALS LA English DT Article DE Muscle; ECM (extracellular matrix); Transplantation; Fibrosis; Trauma; VML (volumetric muscle loss) ID CONTRACTION-INDUCED INJURY; RAT SOLEUS MUSCLE; MDX MICE; GASTROCNEMIUS-MUSCLE; EXTRACELLULAR-MATRIX; BASEMENT-MEMBRANE; SATELLITE CELLS; REGENERATION; REPAIR; RECOVERY AB Tissue engineering strategies that primarily use biological extracellular matrices (ECMs) with or without the inclusion of a stem or progenitor cell source are under development for the treatment of trauma resulting in the loss of a large volume of skeletal muscle (i.e., volumetric muscle loss; VML). The explicit goal is to restore functional capacity to the injured tissue by promoting generation of muscle fibers. In the current study, a syngeneic muscle-derived ECM (mECM) was transplanted in a rat tibialis anterior (TA) muscle VML model. Instead of muscle fiber generation a large fibrotic mass was produced by mECM transplantation out to six months post-injury. Surprisingly, recovery of one-third of the original functional deficit was still achieved by two months post-injury following mECM transplantation. These counterintuitive findings may be due, at least in part, to the ability of mECM to attenuate muscle damage in the remaining muscle as compared to non-repaired muscle. These findings point to a novel role of biological ECMs for the treatment of VML, wherein the remaining muscle mass is protected from prolonged overload injury. Published by Elsevier Ltd. C1 [Corona, Benjamin T.; Wu, Xiaowu; Ward, Catherine L.; McDaniel, Jennifer S.; Rathbone, Christopher R.; Walters, Thomas J.] USA, Inst Surg Res Extrem Trauma & Regenerat Med, Ft Sam Houston, TX 78234 USA. RP Walters, TJ (reprint author), USA, Inst Surg Res Extrem Trauma & Regenerat Med, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM thomas.walters@us.army.mil FU U.S. Army Medical Research and Medical Command [W81XWH-09-2-0177, F_013-2010-USAISR] FX We would like to thank Mrs. Janet Roe,Ms. Melissa Sanchez, and Dr. Kelly Chen for their technical support of this work. Additionally, we thank Dr. Ramon Coronado for his assistance in preparing the milled mECM and Dr. Amit Aurora for his insightful discussion of the findings. This work was funded by the U.S. Army Medical Research and Medical Command (grants: W81XWH-09-2-0177 and F_013-2010-USAISR) awarded to TJW. All components of this study including the decision where to publish were of the sole discretion of the authors. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or reflecting the views of the Department of Defense (AR 360-5) or the United States Government. The authors are employees of the U.S. government and this work was prepared as part of their official duties. NR 57 TC 39 Z9 40 U1 1 U2 38 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0142-9612 J9 BIOMATERIALS JI Biomaterials PD APR PY 2013 VL 34 IS 13 BP 3324 EP 3335 DI 10.1016/j.biomaterials.2013.01.061 PG 12 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA 114VE UT WOS:000316770100017 PM 23384793 ER PT J AU Cheng, G Muench, SP Zhou, Y Afanador, GA Mui, EJ Fomovska, A Lai, BS Prigge, ST Woods, S Roberts, CW Hickman, MR Lee, PJ Leed, SE Auschwitz, JM Rice, DW McLeod, R AF Cheng, Gang Muench, Stephen P. Zhou, Ying Afanador, Gustavo A. Mui, Ernest J. Fomovska, Alina Lai, Bo Shiun Prigge, Sean T. Woods, Stuart Roberts, Craig W. Hickman, Mark R. Lee, Patty J. Leed, Susan E. Auschwitz, Jennifer M. Rice, David W. McLeod, Rima TI Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS LA English DT Article DE TgENR; Triclosan; ADMET; Toxoplasma ID CARRIER PROTEIN REDUCTASE; CONGENITAL TOXOPLASMOSIS; PLASMODIUM-FALCIPARUM; TREATED INFANTS; UNITED-STATES; TRICLOSAN; IDENTIFICATION; DERIVATIVES; ARYLATION; CHILDREN AB Triclosan is a potent inhibitor of Toxoplasma gondii enoyl reductase (TgENR), which is an essential enzyme for parasite survival. In view of triclosan's poor druggability, which limits its therapeutic use, a new set of B-ring modified analogs were designed to optimize its physico-chemical properties. These derivatives were synthesized and evaluated by in vitro assay and TgENR enzyme assay. Some analogs display improved solubility, permeability and a comparable MIC50 value to that of triclosan. Modeling of these inhibitors revealed the same overall binding mode with the enzyme as triclosan, but the B-ring modifications have additional interactions with the strongly conserved Asn130. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Cheng, Gang] Univ Illinois, Dept Med Chem & Pharmacognosy, Drug Discovery Program, Chicago, IL 60612 USA. [Muench, Stephen P.] Univ Leeds, Sch Biomed Sci, Leeds LS2 9JT, W Yorkshire, England. [Zhou, Ying; Mui, Ernest J.; Fomovska, Alina; Lai, Bo Shiun; McLeod, Rima] Univ Chicago, Inst Genom & Syst Biol, Comm Genet, Dept Ophthalmol & Visual Sci, Chicago, IL 60637 USA. [Zhou, Ying; Mui, Ernest J.; Fomovska, Alina; Lai, Bo Shiun; McLeod, Rima] Univ Chicago, Inst Genom & Syst Biol, Comm Immunol, Dept Ophthalmol & Visual Sci, Chicago, IL 60637 USA. [Zhou, Ying; Mui, Ernest J.; Fomovska, Alina; Lai, Bo Shiun; McLeod, Rima] Univ Chicago, Inst Genom & Syst Biol, Comm Mol Med, Dept Ophthalmol & Visual Sci, Chicago, IL 60637 USA. [Zhou, Ying; Mui, Ernest J.; Fomovska, Alina; Lai, Bo Shiun; McLeod, Rima] Univ Chicago, Chicago, IL 60637 USA. [Afanador, Gustavo A.; Prigge, Sean T.] Johns Hopkins Sch Publ Hlth, Baltimore, MD 21205 USA. [Woods, Stuart; Roberts, Craig W.] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow G4 0RE, Lanark, Scotland. [Rice, David W.] Univ Sheffield, Dept Mol Biol & Biotechnol, Sheffield S10 2TN, S Yorkshire, England. [Hickman, Mark R.; Lee, Patty J.; Leed, Susan E.; Auschwitz, Jennifer M.] Walter Reed Army Inst Res, Dept Discovery, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP McLeod, R (reprint author), Univ Chicago, Inst Genom & Syst Biol, Comm Genet, Dept Ophthalmol & Visual Sci, Chicago, IL 60637 USA. EM rmcleod@midway.uchicago.edu RI Roberts, Craig/B-8016-2008; OI Roberts, Craig/0000-0002-0653-835X; Muench, Stephen/0000-0001-6869-4414 FU NIAID [U01 AI082180-0101]; Wellcome Trust; Mann and Cornwell family; Rooney-Alden family; Taub family; Engel family; Mussilami family; MRC [G1000567] FX The authors are grateful for the financial support provided by NIAID grant U01 AI082180-0101 and the Wellcome Trust and the support of the Mann and Cornwell, Rooney-Alden, Taub, Engel and Mussilami families. SPM is funded by an MRC Career Development Fellowship (G1000567). The authors also thank Alan Kozikowski for his contributions. They also thank K. Wroblewski for her assistance with statistical analyses of the in vivo data. The opinions of the authors from Walter Reed Army Institute of Research are their own and do not reflect the official views of the Department of Defense. NR 37 TC 11 Z9 11 U1 1 U2 17 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0960-894X J9 BIOORG MED CHEM LETT JI Bioorg. Med. Chem. Lett. PD APR 1 PY 2013 VL 23 IS 7 BP 2035 EP 2043 DI 10.1016/j.bmcl.2013.02.019 PG 9 WC Chemistry, Medicinal; Chemistry, Organic SC Pharmacology & Pharmacy; Chemistry GA 113CD UT WOS:000316642900024 PM 23453069 ER PT J AU Moore, BA AF Moore, Bret A. TI PTSD: past, present, and future SO CNS SPECTRUMS LA English DT Editorial Material DE posttraumatic stress; evidence based treatment; psychotherapy research; psychopharmacology research; integrated treatment ID POSTTRAUMATIC-STRESS-DISORDER C1 [Moore, Bret A.] USA, Southern Reg Med Command, Warrior Resiliency Program, San Antonio, TX USA. RP Moore, BA (reprint author), Warrior Resiliency Program, 7800 1H 10 West,Suite 300, San Antonio, TX 78230 USA. EM bret.moore@us.army.mil NR 10 TC 0 Z9 0 U1 0 U2 14 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1092-8529 J9 CNS SPECTRUMS JI CNS Spectr. PD APR PY 2013 VL 18 IS 2 BP 71 EP 72 DI 10.1017/S1092852913000187 PG 2 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 119WO UT WOS:000317130200003 PM 23557626 ER PT J AU Brunye, TT Gagnon, SA Paczynski, M Shenhav, A Mahoney, CR Taylor, HA AF Brunye, Tad T. Gagnon, Stephanie A. Paczynski, Martin Shenhav, Amitai Mahoney, Caroline R. Taylor, Holly A. TI Happiness by association: Breadth of free association influences affective states SO COGNITION LA English DT Article DE Affect; Association; Creativity; Positive psychology; Depression ID POSITIVE AFFECT; MOOD; ATTENTION; MEMORY; NEUROGENESIS; INFORMATION; EXPERIENCE; RUMINATION; THOUGHT; BRAIN AB Several studies have demonstrated that affective states influence the number of associations formed between remotely related concepts. Someone in a neutral or negative affective state might draw the association between cold and hot, whereas someone in a positive affective state might spontaneously form the more distant association between cold and sneeze. Could the reverse be true, that generating increasingly broad or narrow associations will put someone in a more or less positive affective state? We test this possibility by using verbal free association tasks, and asking whether the breadth of semantic associativity between cue words and generated responses might predict resulting affective states. Two experiments show that generating broader associations, regardless of their valence, changes affect; specifically, broader associations lowered negative affect and marginally increased positive affect over time. These findings carry implications for theories positing interactions between brain areas mediating associative processing and affect, and may hold promise for enhancing affect in clinical contexts. Published by Elsevier B.V. C1 [Brunye, Tad T.; Gagnon, Stephanie A.; Paczynski, Martin; Mahoney, Caroline R.; Taylor, Holly A.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. [Brunye, Tad T.; Gagnon, Stephanie A.; Mahoney, Caroline R.] USA, NSRDEC, Natick, MA 01760 USA. [Shenhav, Amitai] Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA. [Gagnon, Stephanie A.] Stanford Univ, Dept Psychol, Stanford, CA 94305 USA. RP Brunye, TT (reprint author), Tufts Univ, Dept Psychol, 490 Boston Ave, Medford, MA 02155 USA. EM tbrunye@alumni.tufts.edu NR 35 TC 6 Z9 6 U1 3 U2 29 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0010-0277 J9 COGNITION JI Cognition PD APR PY 2013 VL 127 IS 1 BP 93 EP 98 DI 10.1016/j.cognition.2012.11.015 PG 6 WC Psychology, Experimental SC Psychology GA 112JS UT WOS:000316589100009 PM 23376294 ER PT J AU Allen, JB Cornwell, CF Devine, BD Welch, CR AF Allen, J. B. Cornwell, C. F. Devine, B. D. Welch, C. R. TI Simulations of anisotropic grain growth in single phase materials using Q-state Monte Carlo SO COMPUTATIONAL MATERIALS SCIENCE LA English DT Article DE Grain growth; Anisotropy; Q-state Monte Carlo; Computer simulation ID COMPUTER-SIMULATION; NANOCRYSTALLINE MATERIALS; MICROSTRUCTURE; EVOLUTION; COATINGS; KINETICS; FILMS AB The Q-state Monte Carlo, Potts model is used to investigate 2D, anisotropic, grain growth in single-phase materials using hexagonal grain elements. While many factors can affect the microstructure anisotropy, this research focusses on the role played by grain boundary energy anisotropy. Specifically, for each computed grain orientation and surface normal, the corresponding surface energy is assigned through a mapping process using Wulff plots. Various Wulff plot geometries are considered, and their respective impact on the grain growth anisotropy is evaluated. In addition to demonstrating the utility of this method for use with anisotropic grain growth models, this work advances the state of the art by providing a means of quantifying the degree of anisotropy through the use of statistics generated by frequency distributions of normalized grain radii. Published by Elsevier B.V. C1 [Allen, J. B.; Cornwell, C. F.; Devine, B. D.; Welch, C. R.] USA, Informat Technol Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Allen, JB (reprint author), 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Jeffrey.B.Allen@erdc.dren.mil FU U.S. Army Engineer Research and Development Center Directed Research Program: "Nanoscale Studies of Polycrystalline Materials with Emphasis on Ceramics Synthesis" as part of the Advanced Material Initiative program; U.S. Army Engineer Research and Development Center Directed Research Program: "Effects of Grain Boundaries on Ceramic Properties" as part of the Advanced Material Initiative program FX This study was funded through the U.S. Army Engineer Research and Development Center Directed Research Programs: "Nanoscale Studies of Polycrystalline Materials with Emphasis on Ceramics Synthesis" and "Effects of Grain Boundaries on Ceramic Properties" as part of the Advanced Material Initiative program. NR 25 TC 8 Z9 8 U1 0 U2 20 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0927-0256 J9 COMP MATER SCI JI Comput. Mater. Sci. PD APR PY 2013 VL 71 BP 25 EP 32 DI 10.1016/j.commatsci.2013.01.022 PG 8 WC Materials Science, Multidisciplinary SC Materials Science GA 113IY UT WOS:000316661300004 ER PT J AU Stanley, JK Kennedy, AJ Bednar, AJ Chappell, MA Seiter, JM Averett, DE Steevens, JA AF Stanley, Jacob K. Kennedy, Alan J. Bednar, Anthony J. Chappell, Mark A. Seiter, Jennifer M. Averett, Daniel E. Steevens, Jeffery A. TI Impact assessment of dredging to remove coal fly ash at the Tennessee Valley Authority Kingston Fossil plant using fathead minnow elutriate exposures SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Fly ash; Elutriate; Pimephales promelas; Bioaccumulation; Metal ID PIMEPHALES-PROMELAS; CHRONIC TOXICITY; METAL SEQUESTRATION; AQUATIC ORGANISMS; TISSUE RESIDUES; RAINBOW-TROUT; SELENIUM; CHROMIUM; BIOACCUMULATION; GROWTH AB On December 22, 2008, failure of an earthen containment structure resulted in the release of approximately 4.1 million m3 of coal fly ash into the Emory River and the surrounding area from the Tennessee Valley Authority Kingston Fossil Plant near Kingston, Tennessee, USA. The purpose of the present study was to assess the potential of dredging activities performed to remove the fly ash from the river to result in increased risk to pelagic fish, with special consideration of mobilization of metals. Elutriates were created using two sources of fly ash by bubbling with air over 10 d. This elutriate preparation method was designed to represent worst-case conditions for oxidation, metal release, and dissolution. Larval and juvenile Pimephales promelas underwent 10-d exposures to these elutriates. Larval end points included survival and biomass, and juvenile end points included survival, length, biomass, liver somatic index, and bioaccumulation. No significant toxicity was observed. Bioaccumulation of metals in juveniles was found to be primarily attributable to metals associated with particles in the gut. Results suggest little potential for toxicity to related fish species due to fly ash removal dredging activities given the extreme conditions represented by the elutriates in the present study. Environ. Toxicol. Chem. 2013;32:822830. (c) 2013 SETAC C1 [Stanley, Jacob K.; Kennedy, Alan J.; Bednar, Anthony J.; Chappell, Mark A.; Seiter, Jennifer M.; Averett, Daniel E.; Steevens, Jeffery A.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. RP Stanley, JK (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. EM jacob.k.stanley@us.army.mil NR 37 TC 5 Z9 5 U1 4 U2 21 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD APR PY 2013 VL 32 IS 4 BP 822 EP 830 DI 10.1002/etc.2137 PG 9 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 112VG UT WOS:000316621700013 PM 23354755 ER PT J AU Pushpakaran, BN Hinojosa, M Bayne, SB Veliadis, V Urciuoli, D El-Hinnawy, N Borodulin, P Gupta, S Scozzie, C AF Pushpakaran, Bejoy N. Hinojosa, Miguel Bayne, Stephen B. Veliadis, Victor Urciuoli, Damian El-Hinnawy, Nabil Borodulin, Pavel Gupta, Shalini Scozzie, Charles TI High Temperature Unclamped Inductive Switching Mode Evaluation of SiC JFET SO IEEE ELECTRON DEVICE LETTERS LA English DT Article DE 1200 V; high temperature; junction field-effect transistor (JFET); pulsed testing; silicon carbide (SiC); triode breakdown; unclamped inductive switching (UIS) ID PERFORMANCE AB Silicon carbide (SiC) unipolar transistors are an efficient choice in the design of high temperature 1200 V switching power supplies and dc-dc converters. To reduce the form factor and increase the power density of the circuit, the switching frequency must be high. This intensifies the negative impact of parasitic inductance and results in high voltage spikes that can drive a switching device into breakdown, followed by rapid destruction. To study the device performance under unclamped inductive switching (UIS) conditions, a normally-ON 1200 V/13-A SiC junction field-effect transistor (JFET) is driven into punch through breakdown using a single pulse. The testing is performed using an UIS setup, in which energy initially stored in an inductor is discharged through the JFET. The testing comprises of 90 single pulses each at 25 degrees C and 100 degrees C case temperatures for different gate voltages and drain current values. The peak energy and power dissipated in the JFET are 621 mJ and 16 kW, respectively, at the rated 1200 V blocking voltage and 13-A drain current. The JFET triode breakdown characteristics are unchanged after 180 single-pulse switching events indicating the robust nature of the device under extreme breakdown conditions. In addition, the 621 mJ peak UIS energy and its corresponding 8871 mJ/cm(2) density dissipated in the JFET are the highest reported for any SiC power device. C1 [Pushpakaran, Bejoy N.; Hinojosa, Miguel; Bayne, Stephen B.] Texas Tech Univ, Dept Elect & Comp Engn, Lubbock, TX 79409 USA. [Veliadis, Victor; El-Hinnawy, Nabil; Borodulin, Pavel; Gupta, Shalini] Northrop Grumman Elect Syst, Linthicum, MD 21090 USA. [Urciuoli, Damian; Scozzie, Charles] USA, Res Lab, Adelphi, MD 20783 USA. RP Pushpakaran, BN (reprint author), Texas Tech Univ, Dept Elect & Comp Engn, Lubbock, TX 79409 USA. EM bejoy.pushpakaran@ttu.edu; miguel.hinojosa@ttu.edu; stephen.bayne@ttu.edu; vic-tor.veliadis@ngc.com; damian.urciuoli@us.army.mil; nabil.elhinnawy@ngc.com; pavel.borodulin@ngc.com; shalini.gupta@ngc.com; charles.scozzie@us.army.mil OI Pushpakaran, Bejoy/0000-0002-1342-5951 FU U.S. Army Research Laboratory FX This work was supported by the U.S. Army Research Laboratory. The review of this letter was arranged by Editor S.-H. Ryu. NR 11 TC 7 Z9 7 U1 0 U2 12 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0741-3106 EI 1558-0563 J9 IEEE ELECTR DEVICE L JI IEEE Electron Device Lett. PD APR PY 2013 VL 34 IS 4 BP 526 EP 528 DI 10.1109/LED.2013.2247020 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA 115LG UT WOS:000316813100017 ER PT J AU Wei, W He, T Bisdikian, C Goeckel, D Jiang, B Kaplan, L Towsley, D AF Wei, Wei He, Ting Bisdikian, Chatschik Goeckel, Dennis Jiang, Bo Kaplan, Lance Towsley, Don TI Impact of In-Network Aggregation on Target Tracking Quality Under Network Delays SO IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS LA English DT Article DE In-network aggregation; Target tracking; Brownian motion; Mean squared error ID WIRELESS SENSOR NETWORKS; CLASSIFICATION AB In this paper, we investigate how in-network aggregation approach impacts the target tracking quality in multi-hop wireless sensor networks under network delays. Specifically, we use the mean squared error (MSE) of the target location estimate to quantify the target tracking quality, and investigate how in-network aggregation affects the MSE. To obtain insights without being obscured by onerous mathematical details, we assume a Brownian motion mobility model for the target, Gaussian measurement noise for the sensors, and independent per-hop delays. Under the above assumptions, we first propose an aggregation scheme that preserves a sufficient statistic for optimal tracking under data aggregation at the intermediate nodes and arbitrary network delays. We then analytically study the impact of aggregation in three increasingly more complicated scenarios: single task tracking with only transmission delay, single task tracking with both transmission delay and queueing delay at intermediate nodes, and multi-task tracking. Our results demonstrate that in-network aggregation improves tracking quality in all three scenarios. Furthermore, our analysis provides guidelines on how to choose aggregation parameters in practice. C1 [Wei, Wei; Jiang, Bo; Towsley, Don] Univ Massachusetts, Dept Comp Sci, Amherst, MA 01003 USA. [He, Ting; Bisdikian, Chatschik] IBM TJ Watson Res Ctr, Hawthorne, NY 10532 USA. [Goeckel, Dennis] Univ Massachusetts, Dept Elect & Comp Engn, Amherst, MA 01003 USA. [Kaplan, Lance] USA, Res Lab, Adelphi, MD 20783 USA. RP Wei, W (reprint author), Univ Massachusetts, Dept Comp Sci, Amherst, MA 01003 USA. EM wei-wei@cs.umass.edu FU National Science Foundation [EEC-0313747]; U.S. Army Research Laboratory; U.K. Ministry of Defence [W911NF-06-3-0001] FX This work was sponsored in part by the National Science Foundation under grants EEC-0313747, and by the U.S. Army Research Laboratory and the U.K. Ministry of Defence and was accomplished under Agreement Number W911NF-06-3-0001. The views and conclusions contained in this document are those of the author(s) and should not be interpreted as representing the official policies, either expressed or implied, of the U. S. Army Research Laboratory, the U. S. Government, the U. K. Ministry of Defence or the U. K. Government. The U. S. and U. K. Governments are authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. NR 28 TC 1 Z9 2 U1 1 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0733-8716 J9 IEEE J SEL AREA COMM JI IEEE J. Sel. Areas Commun. PD APR PY 2013 VL 31 IS 4 BP 808 EP 818 DI 10.1109/JSAC.2013.130416 PG 11 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 115HB UT WOS:000316802100016 ER PT J AU Wilk, JE Bliese, PD Thomas, JL Wood, MD McGurk, D Castro, CA Hoge, CW AF Wilk, Joshua E. Bliese, Paul D. Thomas, Jeffrey L. Wood, Michael D. McGurk, Dennis Castro, Carl A. Hoge, Charles W. TI Unethical Battlefield Conduct Reported by Soldiers Serving in the Iraq War SO JOURNAL OF NERVOUS AND MENTAL DISEASE LA English DT Article DE Combat; ethics; posttraumatic stress disorder ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; COMBAT EXPOSURE; POPULATION; VIETNAM; VIOLENCE; PREVALENCE; DEPLOYMENT; SYMPTOMS; MILITARY AB Research involving military service members has shown a strong relationship between combat experiences and increased risk for posttraumatic stress disorder (PTSD) and other mental health problems. Comparatively little research has examined the relationship between combat experiences, PTSD, aggression, and unethical conduct on the battlefield, although news stories sometimes suggest links between unethical conduct and disorders such as PTSD. This study systematically examined whether unethical conduct is a proxy for aggression and whether specific combat experiences and PTSD are independently associated with unethical behavior. The results of this study indicate that aggression (beta = 0.30) and specific combat experiences (particularly, witnessing war atrocities [beta = 0.14] and fighting [beta = 0.13]) are much more strongly associated with unethical conduct than is PTSD (beta = 0.04). C1 [Wilk, Joshua E.; Bliese, Paul D.; Thomas, Jeffrey L.; McGurk, Dennis; Hoge, Charles W.] USA, Med Res & Mat Command, Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD USA. [Wood, Michael D.] USA, Med Res & Mat Command, Med Res Unit Europe, Walter Reed Army Inst Res, Heidelberg, Germany. [Castro, Carl A.] USA, Med Res & Mat Command, Mil Operat Med Res Program, Frederick, MD USA. RP Wilk, JE (reprint author), Walter Reed Army Inst Res, Dept Mil Psychiat, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM joshua.wilk@amedd.army.mil NR 33 TC 3 Z9 3 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-3018 J9 J NERV MENT DIS JI J. Nerv. Ment. Dis. PD APR PY 2013 VL 201 IS 4 BP 259 EP 265 DI 10.1097/NMD.0b013e318288d302 PG 7 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 117HV UT WOS:000316945100001 PM 23538969 ER PT J AU Zachar, MR Labella, C Kittle, CP Baer, PB Hale, RG Chan, RK AF Zachar, Michael R. Labella, Carl Kittle, Christopher P. Baer, Pamela Brown Hale, Robert G. Chan, Rodney K. TI Characterization of Mandibular Fractures Incurred From Battle Injuries in Iraq and Afghanistan From 2001-2010 SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Article ID MAXILLOFACIAL FRACTURES; FACIAL FRACTURES; ENDURING FREEDOM; NECK INJURIES; BLAST; PATTERNS; MANAGEMENT; TRENDS; HEAD AB Purpose: The mandible is the most commonly fractured bone in the craniomaxillofacial skeleton among military casualties. The purpose of this study was to characterize the nature and severity of mandibular fractures incurred by US military personnel during combat. Materials and Methods: We queried the Joint Theater Trauma Registry from October 2001 to April 2011 using all pertinent International Classification of Diseases, Ninth Revision codes to identify fractures of the mandible. Fractures were then classified based on type and location. Chart reviews were performed on the subset of patients who were treated at San Antonio Military Medical Center to further classify the anatomic pattern and treatment of these fractures. Results: We identified 391 patients with mandibular fractures, of whom 45 were transferred to San Antonio Military Medical Center. Open fractures were seen in 75% of patients. Two or more fractures of the mandible were seen in 51% of patients. Comminuted fractures were present in 84%, and 31% had segmental losses. Eighty-six percent of fractures were operative; two-thirds of patients required a single surgical procedure, whereas the remaining one-third required multiple procedures. Forty-six percent of patients had pan-facial fractures. Conclusions: Mandibular fractures as a result of combat blast injuries were characterized by a high incidence of open, comminuted, multiple fractures. Associated facial fractures were common. (C) 2013 American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 71:734-742, 2013 C1 [Zachar, Michael R.; Labella, Carl; Kittle, Christopher P.] San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA. [Baer, Pamela Brown; Hale, Robert G.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Chan, Rodney K.] USA, Inst Surg Res, Clin Div, Ft Sam Houston, TX 78234 USA. RP Chan, RK (reprint author), San Antonio Mil Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM rodney.k.chan@amedd.army.mil OI Brown Baer, Pamela/0000-0001-6964-1955 NR 26 TC 6 Z9 6 U1 0 U2 3 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD APR PY 2013 VL 71 IS 4 BP 734 EP 742 DI 10.1016/j.joms.2012.10.030 PG 9 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 114MP UT WOS:000316745800024 PM 23351482 ER PT J AU Geringer, JR Tuan, CY Lindsey, PD AF Geringer, J. R. Tuan, C. Y. Lindsey, P. D. TI Assessment of Software for Blast Loading and Structural Response Analysis Using a Lightweight Steel-Joist Roof as a Test Case SO JOURNAL OF PERFORMANCE OF CONSTRUCTED FACILITIES LA English DT Article; Proceedings Paper CT 6th ASCE Forensic Engineering Congress CY OCT 31-NOV 03, 2012 CL San Francisco, CA SP ASCE DE Blast loads; Steel structures; Joist; Finite-element models; DYNA3D; STAAD; SBEDS; ConWep; BlastX AB The purpose of this paper is to evaluate the current multihazard loading environments when future blast loadings are included. While most of the currently available software programs for the physical testing of normal design loading conditions have been validated, the testing does not include the blast environment. It has not been determined whether these programs can be used when blast loads are included. Currently, designers use multiple software packages to perform multihazard analyses when blast loads are involved, making it difficult to compare the results. This analysis has as major topics air-blast and structural responses. The three standard air-blast codes used are ConWep, BlastX, and SBEDS, and the four structural response codes used are SBEDS, STAAD, ADINA, and DYNA3D. All analyses are compared against a test series that loaded standard open web steel joist sections dynamically with an air-blast load. This paper compares the output and results of each program against the test results to determine if the software is comparable in an effort to simplify the multihazard analysis process. DOI: 10.1061/(ASCE)CF.1943-5509.0000299. (C) 2013 American Society of Civil Engineers. C1 [Geringer, J. R.; Lindsey, P. D.] USA, Corps Engineers, Protect Design Ctr, Omaha, NE 68102 USA. [Tuan, C. Y.] Univ Nebraska Lincoln, Dept Civil Engn, Omaha, NE 68182 USA. EM john.r.geringer@usace.army.mil NR 16 TC 0 Z9 0 U1 0 U2 13 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0887-3828 EI 1943-5509 J9 J PERFORM CONSTR FAC JI J. Perform. Constr. Facil. PD APR PY 2013 VL 27 IS 2 BP 144 EP 154 DI 10.1061/(ASCE)CF.1943-5509.0000299 PG 11 WC Construction & Building Technology; Engineering, Civil SC Construction & Building Technology; Engineering GA 118ZK UT WOS:000317065900003 ER PT J AU Rens, KL Liu, R Foltz, SD AF Rens, Kevin L. Liu, Rui Foltz, Stuart D. TI Sustainable Approach for Optimal Steel Sheet Pile Structure Assessment, Maintenance, and Rehabilitation SO JOURNAL OF PERFORMANCE OF CONSTRUCTED FACILITIES LA English DT Article; Proceedings Paper CT 6th ASCE Forensic Engineering Congress CY OCT 31-NOV 03, 2012 CL San Francisco, CA SP ASCE DE Steel sheet pile; Assessment; Maintenance; Rehabilitation; Sustainability; Life-cycle cost analysis AB An improved steel sheet pile (SSP) inspection procedure is proposed in this paper, which couples the field inspection condition-index methodology previously developed by the U. S. Army Corps of Engineers with reliability assessments to quantify the life-cycle costs and environmental impacts associated with various maintenance and repair (M&R) scenarios. Maintenance and repair strategies over the analysis period (from present to the end of the structure's lifetime) are determined through reliability assessment for structures with relatively low condition indices. The level of maintenance activity is then to be determined by the life-cycle cost analysis and environmental life-cycle assessment of M&R alternatives. The optimal M&R alternative is the one with the lowest cost combined with minimal environmental impact. Using these methodologies, the SSP structure owners will gain improved capabilities to monitor present-day conditions of SSP infrastructure and prioritize structures that will require sustainable M&R. Further research is proposed to collect real field-inspection data and create M&R records that can be used to estimate the reliability more accurately. In addition, the methodology developed for this relatively simple type of structure can be extended to more complex and critical structural systems such as gates, valves, and other components making up locks, dams, and other related navigational facilities. DOI: 10.1061/(ASCE)CF.1943-5509.0000301. (C) 2013 American Society of Civil Engineers. C1 [Rens, Kevin L.; Liu, Rui] Univ Colorado, Dept Civil Engn, Denver, CO 80217 USA. [Foltz, Stuart D.] USA, Construct Engn Res Lab, Champaign, IL 61826 USA. EM Kevin.rens@ucdenver.edu; rui.liu@ucdenver.edu; Stuart.D.Foltz@usace.army.mil FU U.S. Army Construction Engineering Research Laboratory [W9132T-10-P-0082] FX This study was funded by the U.S. Army Construction Engineering Research Laboratory under Project No. W9132T-10-P-0082. NR 27 TC 0 Z9 0 U1 3 U2 16 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0887-3828 EI 1943-5509 J9 J PERFORM CONSTR FAC JI J. Perform. Constr. Facil. PD APR PY 2013 VL 27 IS 2 BP 181 EP 190 DI 10.1061/(ASCE)CF.1943-5509.0000301 PG 10 WC Construction & Building Technology; Engineering, Civil SC Construction & Building Technology; Engineering GA 118ZK UT WOS:000317065900007 ER PT J AU Delaney, HM Wang, E Melish, M AF Delaney, H. M. Wang, E. Melish, M. TI Comprehensive strategy including prophylactic mupirocin to reduce Staphylococcus aureus colonization and infection in high-risk neonates SO JOURNAL OF PERINATOLOGY LA English DT Article DE Staphylococcus aureus; methicillin-resistant Staphylococcus aureus; neonatal intensive care unit; mupirocin; surveillance ID INTENSIVE-CARE UNITS; NASAL MUPIROCIN; NOSOCOMIAL-INFECTIONS; INTRANASAL MUPIROCIN; SURVEILLANCE; RESISTANCE; OUTBREAK; OINTMENT; INFANTS; TRENDS AB OBJECTIVE: To examine the use of long-term prophylactic mupirocin as part of a comprehensive strategy in reducing Staphylococcus aureus colonization and infection in a neonatal intensive care unit (NICU). STUDY DESIGN: Twice daily mupirocin was applied to all infants admitted to the NICU throughout hospitalization starting in 2004. S. aureus surveillance was implemented in 2008. The efficacy of these practices was evaluated with a retrospective review of infants admitted from 2004 to 2010 found to be colonized or infected with S. aureus. RESULT: During the study period, 66 of 6283 NICU infants had a S. aureus infection With 67% methicillin resistance. There were three distinctive S. aureus outbreaks, the first being a methicillin-resistant strain July 2004. After implementation of daily mupirocin, the outbreak was eradicated and the rate of S. aureus infection significantly decreased (1.82 to 0.40/1000 patient-days-at-risk, P=0.0049). Mupirocin was discontinued March 2005 followed by a methicillin-sensitive S. aureus outbreak November 2005. In December 2005, mupirocin was reinstituted and has continued to present day, again significantly reducing S. aureus infections (1.42 to 0.33/1000 patient-days-at-risk, P<0.0001) with zero isolates resistant to mupirocin. In the pre-mupirocin period, S. aureus colonization was upwards of 60% now with rates typically <5%. S. aureus colonization strongly predicted later invasive infection (P<0.0001). CONCLUSION: Although controversial, prophylactic mupirocin in all NICU infants has acted as a barrier to colonization and markedly decreased S. aureus infection rates over a 5-year period. Journal of Perinatology (2013) 33, 313-318; doi:10.1038/jp.2012.102; published online 23 August 2012 C1 [Delaney, H. M.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. [Wang, E.] Univ Hawaii, Undergrad Sch, Honolulu, HI 96822 USA. [Melish, M.] Kapiolani Med Ctr Women & Children, Dept Pediat, Honolulu, HI USA. RP Delaney, HM (reprint author), Tripler Army Med Ctr, Dept Pediat, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM heather.delaney@amedd.army.mil NR 30 TC 19 Z9 19 U1 0 U2 7 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0743-8346 J9 J PERINATOL JI J. Perinatol. PD APR PY 2013 VL 33 IS 4 BP 313 EP 318 DI 10.1038/jp.2012.102 PG 6 WC Obstetrics & Gynecology; Pediatrics SC Obstetrics & Gynecology; Pediatrics GA 115SX UT WOS:000316833300013 PM 22918547 ER PT J AU Rupp, TL Wesensten, NJ Newman, R Balkin, TJ AF Rupp, Tracy L. Wesensten, Nancy J. Newman, Rachel Balkin, Thomas J. TI PER3 and ADORA2A polymorphisms impact neurobehavioral performance during sleep restriction SO JOURNAL OF SLEEP RESEARCH LA English DT Article DE cognitive performance; genetic polymorphisms; individual differences; recovery sleep; sleep restriction ID GENETIC-VARIATION; PHASE SYNDROME; DEPRIVATION AB The objective of the study was to determine whether ADORA2A or PER3 polymorphisms contribute to individual responsivity to sleep restriction. Nineteen healthy adults (ages 1839, 11 males, 8 females) underwent sleep restriction (SR) which consisted of seven nights of 3h time in bed (TIB) (04:0007:00). SR was preceded by seven in-laboratory nights of 10h TIB (21:0007:00) and followed by three nights of 8h TIB (23:0007:00). Volunteers underwent psychomotor vigilance, objective alertness, and subjective sleepiness assessments throughout. Volunteers were genotyped for the PER3 VNTR polymorphism (PER34/4 n=7; PER34/5 n=10; PER35/5 n=2) and the ADORA2A c.1083T>C polymorphism, (ADORA2AC/T n=9; ADORA2AT/T n=9; ADORA2AC/C n=1) using polymerase chain reaction (PCR). Separate mixed-model anovas were used to assess contributions of ADORA2A and PER3 polymorphisms. Results showed that PER34/4 and ADORA2AC/T individuals expressed greater behavioral resiliency to SR compared to PER4/5and ADORA2AT/T individuals. Our findings contrast with previously reported non-significant effects for the PER3 polymorphism under a less challenging sleep restriction regimen (4h TIB per night for five nights). We conclude that PER3 and ADORA2A polymorphisms become more behaviorally salient with increasing severity and/or duration of sleep restriction (based on psychomotor vigilance). Given the small sample size these results are preliminary and require replication. C1 [Rupp, Tracy L.; Wesensten, Nancy J.; Newman, Rachel; Balkin, Thomas J.] Walter Reed Army Inst Res, Behav Biol Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Wesensten, NJ (reprint author), Walter Reed Army Inst Res, Behav Biol Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM nancy.wesensten@US.army.mil FU US Army Medical Research and Materiel Command FX This material has been reviewed by the Walter Reed Army Institute of Research, and there is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the position of the Department of the Army of the Department of Defense. This work was supported by the US Army Medical Research and Materiel Command. We thank the student contractors, military personnel, on-call physicians Drs. John Hughes and Melanie Guerrero, and study participants. NR 14 TC 13 Z9 13 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0962-1105 J9 J SLEEP RES JI J. Sleep Res. PD APR PY 2013 VL 22 IS 2 BP 160 EP 165 DI 10.1111/j.1365-2869.2012.01062.x PG 6 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 117OX UT WOS:000316964100007 PM 23171222 ER PT J AU Klemcke, HG DeKroon, RM Mocanu, M Robinette, JB Alzate, O AF Klemcke, Harold G. DeKroon, Robert M. Mocanu, Mihaela Robinette, Jennifer B. Alzate, Oscar TI Cardiac mitochondrial proteomic expression in inbred rat strains divergent in survival time after hemorrhage SO PHYSIOLOGICAL GENOMICS LA English DT Article DE inbred rats; hemorrhage; proteomics; respiration; cellular pathways; mitochondrial proteomics; 2D DIGE; quantitative intact proteomics ID ACYL-COA DEHYDROGENASE; COMBAT CASUALTY CARE; HYDROGEN-SULFIDE; ALDEHYDE DEHYDROGENASE; MYOCARDIAL-ISCHEMIA; GEL-ELECTROPHORESIS; ELECTRON-TRANSPORT; BASE-LINE; CARNITINE PALMITOYLTRANSFERASE-2; ISCHEMIA/REPERFUSION INJURY AB We have previously identified inbred rat strains differing in survival time to a severe controlled hemorrhage (StaH). In efforts to identify cellular mechanisms and ultimately genes that are important contributors to enhanced STaH, we conducted a study to characterize potential differences in cardiac mitochondrial proteins in these rats. Inbred rats from three strains [Brown Norway/Medical College of Wisconsin (BN); Dark Agouti (DA), and Fawn Hooded Hypertensive (FHH)] with different StaH (DA = FHH > BN) were assigned to one of three treatment groups (n = 4/strain): nonoperated controls, surgically catheterized rats, or rats surgically catheterized and hemorrhaged 24 h postsurgery. Rats were euthanized 30 min after handling or 30 min after initiation of a 26 min hemorrhage. After euthanasia, hearts were removed and mitochondria isolated. Differential protein expression was determined using 2D DIGE-based Quantitative Intact Proteomics and proteins identified by MALDI/TOF mass spectrometry. Hundreds of proteins (791) differed among inbred rat strains (P <= 0.038), and of these 81 were identified. Thirty-eight were unique proteins and 43 were apparent isoforms. For DA rats (longest STaH), 36 proteins increased and 30 decreased compared with BN (shortest STaH). These 81 proteins were associated with lipid (e.g., acyl CoA dehydrogenase) and carbohydrate (e.g., fumarase) metabolism, oxidative phosphorylation (e.g., ubiquinol-cytochrome C reductase), ATP synthesis (F-1 ATPase), and H2S synthesis (3-mercaptopyruvate sulfurtransferase). Although we cannot make associations between these identified mitochondrial proteins and StaH, our data do provide evidence for future candidate proteins with which to consider such associations. C1 [Klemcke, Harold G.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [DeKroon, Robert M.; Mocanu, Mihaela; Robinette, Jennifer B.; Alzate, Oscar] Univ N Carolina, Syst Prote Core Lab, Chapel Hill, NC USA. [Mocanu, Mihaela; Robinette, Jennifer B.; Alzate, Oscar] Univ N Carolina, Program Mol Biol & Biotechnol, Chapel Hill, NC 27599 USA. [DeKroon, Robert M.; Alzate, Oscar] Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC USA. RP Klemcke, HG (reprint author), USA, Inst Surg Res, 3650 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM harold.klemcke@amedd.army.mil NR 140 TC 0 Z9 0 U1 11 U2 22 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 1094-8341 J9 PHYSIOL GENOMICS JI Physiol. Genomics PD APR PY 2013 VL 45 IS 7 BP 243 EP 255 DI 10.1152/physiolgenomics.00118.2012 PG 13 WC Cell Biology; Genetics & Heredity; Physiology SC Cell Biology; Genetics & Heredity; Physiology GA 118CJ UT WOS:000316999800001 PM 23386204 ER PT J AU Greitens, SC Koehler-Derrick, G AF Greitens, Sheena Chestnut Koehler-Derrick, Gabriel TI Technology, Data, and Politics Introduction SO PS-POLITICAL SCIENCE & POLITICS LA English DT Editorial Material C1 [Greitens, Sheena Chestnut] Harvard Univ, Cambridge, MA 02138 USA. [Koehler-Derrick, Gabriel] US Mil Acad, West Point, NY USA. RP Greitens, SC (reprint author), Harvard Univ, Cambridge, MA 02138 USA. NR 13 TC 0 Z9 0 U1 0 U2 1 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1049-0965 J9 PS-POLIT SCI POLIT JI PS-Polit. Sci. Polit. PD APR PY 2013 VL 46 IS 2 BP 259 EP 261 DI 10.1017/S1049096513000255 PG 3 WC Political Science SC Government & Law GA 117ZN UT WOS:000316992200010 ER PT J AU Koehler-Derrick, G AF Koehler-Derrick, Gabriel TI Quantifying Anecdotes: Google Search Data and Political Developments in Egypt SO PS-POLITICAL SCIENCE & POLITICS LA English DT Article C1 US Mil Acad, West Point, NY 10996 USA. RP Koehler-Derrick, G (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 35 TC 1 Z9 1 U1 0 U2 3 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1049-0965 J9 PS-POLIT SCI POLIT JI PS-Polit. Sci. Polit. PD APR PY 2013 VL 46 IS 2 BP 291 EP 298 DI 10.1017/S1049096513000267 PG 8 WC Political Science SC Government & Law GA 117ZN UT WOS:000316992200014 ER PT J AU Omelchenko, IV Shishkin, OV Gorb, L Hill, FC Leszczynski, J AF Omelchenko, Irina V. Shishkin, Oleg V. Gorb, Leonid Hill, Frances C. Leszczynski, Jerzy TI Substituent effects and aromaticity of six-membered heterocycles SO STRUCTURAL CHEMISTRY LA English DT Article DE Aromaticity; Heteroaromaticity; Substituted heterocycles; Quantum chemical calculations; Push-pull effect ID PI-ELECTRON DELOCALIZATION; CONFORMATIONAL FLEXIBILITY; PYRYLIUM-SALTS; AB-INITIO; BENZENE; RING; STATE; STABILIZATION; SILABENZENES; ARSABENZENE AB Structure, aromaticity, relative stability, and conformational flexibility of nitro and amino substituted monoheterocyclic analogous of benzene were studied by ab initio quantum-chemical method at MP2/aug-cc-pvDZ level of theory. Amino derivatives were found to be slightly less aromatic than nitro derivatives. Strong push-pull interactions were found in alpha- and gamma-aminochalcogenopyrylium cations and, in less extent, in alpha- and gamma-aminopyrydines. These molecules are less aromatic but more stable, as compare to their beta-isomers. All heterocycles with 3rd and 4th row heteroatoms reveal C-NO2 bond elongation accompanied by C-Heteroatom bond shortening in beta-nitro isomers, and strong inequality of two endocyclic C-Heteroatom bonds in alpha-amino isomers. C1 [Omelchenko, Irina V.; Shishkin, Oleg V.] Natl Acad Sci Ukraine, STC Inst Single Crystals, UA-61001 Kharkov, Ukraine. [Shishkin, Oleg V.] Kharkov Natl Univ, UA-61077 Kharkov, Ukraine. [Gorb, Leonid] Badger Tech Serv LLC, Vicksburg, MS USA. [Hill, Frances C.; Leszczynski, Jerzy] USA, Erdc, Vicksburg, MS 39180 USA. [Leszczynski, Jerzy] Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA. RP Omelchenko, IV (reprint author), Natl Acad Sci Ukraine, STC Inst Single Crystals, 60 Lenina Ave, UA-61001 Kharkov, Ukraine. EM irina@xray.isc.kharkov.com OI Omelchenko, Iryna/0000-0002-6882-6832 NR 81 TC 6 Z9 6 U1 1 U2 40 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1040-0400 J9 STRUCT CHEM JI Struct. Chem. PD APR PY 2013 VL 24 IS 2 BP 725 EP 733 DI 10.1007/s11224-012-0124-x PG 9 WC Chemistry, Multidisciplinary; Chemistry, Physical; Crystallography SC Chemistry; Crystallography GA 109WT UT WOS:000316401700036 ER PT J AU Kang, JG Kim, HC Choi, CY Nam, HY Chae, HY Chong, ST Klein, TA Ko, S Chae, JS AF Kang, Jun-Gu Kim, Heung-Chul Choi, Chang-Yong Nam, Hyun-Young Chae, Hee-Young Chong, Sung-Tae Klein, Terry A. Ko, Sungjin Chae, Joon-Seok TI Molecular Detection of Anaplasma, Bartonella, and Borrelia Species in Ticks Collected from Migratory Birds from Hong-do Island, Republic of Korea SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Anaplasma; Bartonella; Borrelia; Tick-borne pathogens; Migratory bird; Korea ID IXODES-RICINUS TICKS; SMALL MAMMALS; LYME-DISEASE; GENETIC-VARIANTS; PCR DETECTION; EHRLICHIA; IDENTIFICATION; JAPAN; PHAGOCYTOPHILUM; BOVIS AB Bird migration is a recurring annual and seasonal event undertaken by more than 100 species of birds in the southeast Asian and northeast Palearctic regions that pass through or remain for short periods from April to May and September to November at Hong-do Island, Republic of Korea (ROK). A total of 212 ticks (40 Haemaphysalis flava, 12 H. longicornis, 146 Ixodes turdus, 13 I. nipponensis, and 1 I. ornithophila) were collected from 65/2,161 (3.0%) migratory birds consisting of 21 species that were captured from January, 2008, through December, 2009, as part of the Migratory Birds Center, Hong-do bird banding program for studying bird migration patterns. Adult ticks were assayed individually while larvae and nymphs were pooled (1-22 and 1-6 ticks per pool, respectively) into 31 and 65 pools, respectively. Ticks were assayed for zoonotic pathogens by PCR using 16S rRNA, heat shock protein (groEL), and internal transcribed spacer (ITS) gene primers to amplify genera specific for Anapalsma, Bartonella, and Borrelia PCR amplicons. Using the 16S rRNA-based nested PCR, A. phagocytophilum (n = 1) was detected in I. nipponensis collected from Zoothera sibirica and A. bovis (n = 1) was detected in I. turdus collected from Emberiza chrysophrys. Borrelia turdi 16S rRNA genes (n = 3) were detected in I. turdus and I. nipponensis collected from Turdus pallidus and Zoothera aurea. Borrelia spp. 16S rRNA genes (n = 4) were detected in Ixodes ticks collected from Emberiza tristrami, T. pallidus, and Z. aurea. The Bartonella grahamii ITS gene (n = 1) was detected by nested PCR assay in I. turdus collected from Z. aurea. These results provide insight into the potential role of migratory birds in the dispersal of ticks and associated tick-borne pathogens throughout their ranges in Asia. C1 [Kang, Jun-Gu; Ko, Sungjin; Chae, Joon-Seok] Seoul Natl Univ, Res Inst Vet Sci, Lab Vet Internal Med, Seoul 151742, South Korea. [Kang, Jun-Gu; Ko, Sungjin; Chae, Joon-Seok] Seoul Natl Univ, Coll Vet Med, Seoul 151742, South Korea. [Kim, Heung-Chul; Chong, Sung-Tae] 168th Multifunct Med Battal, Med Detachment 5, Med Brigade 65, Unit 15247, APO, AP 96205 USA. [Choi, Chang-Yong; Nam, Hyun-Young; Chae, Hee-Young] Natl Pk Res Inst, Migratory Birds Ctr, Shinan Gun, Jeollanam Prov, South Korea. [Klein, Terry A.] US Army MEDDAC Korea, Med Brigade 65, APO, AP 96205 USA. RP Chae, JS (reprint author), Seoul Natl Univ, Coll Vet Med, Lab Vet Internal Med, Seoul 151742, South Korea. EM jschae@snu.ac.kr OI Choi, Chang-Yong/0000-0002-4519-7957 FU National Research Foundation of Korea; Korean Government [2011-0015349]; Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response System, Silver Spring, MD; National Center for Military Intelligence, Ft. Detrick, MD FX This research was supported by a National Research Foundation of Korea Grant funded by the Korean Government (2011-0015349), and funding for portions of this work was provided by the Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response System, Silver Spring, MD, and the National Center for Military Intelligence, Ft. Detrick, MD. We thank the members of Migratory Bird Center, National Park Research Institute, for bird tick collections during their bird-banding surveys. We especially thank Dr. Joel Gaydos, Global Emerging Infections Surveillance and Response System, Silver Spring, MD, USA, for his support and constructive criticism. NR 45 TC 27 Z9 27 U1 1 U2 21 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD APR PY 2013 VL 13 IS 4 BP 215 EP 225 DI 10.1089/vbz.2012.1149 PG 11 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 115EM UT WOS:000316795400002 PM 23428091 ER PT J AU Zhang, A Chinnawirotpisan, P Tang, YX Zhou, YF Lynch, J Thomas, S Kalayanarooj, S Putnak, R Zhang, CL AF Zhang, Aimee Chinnawirotpisan, Piyawan Tang, Yuxin Zhou, Yanfei Lynch, Julia Thomas, Stephen Kalayanarooj, Siripen Putnak, Robert Zhang, Chunlin TI Intra-genotypic variation of predominant genotype II strains of dengue type-3 virus isolated during different epidemics in Thailand from 1973 to 2001 SO VIRUS GENES LA English DT Article DE Dengue type-3 virus; Sequence comparison; Intra-genetic variation ID NF-KAPPA-B; MOLECULAR EPIDEMIOLOGY; NEUROBLASTOMA-CELLS; HEMORRHAGIC-FEVER; APOPTOSIS; BANGKOK; FLAVIVIRUSES; INHIBITION; MECHANISMS; SEROTYPE-3 AB The prevalence of all four dengue virus (DENV) serotypes has increased dramatically in recent years in many tropical and sub-tropical countries accompanied by an increase in genetic diversity within each serotype. This expansion in genetic diversity is expected to give rise to viruses with altered antigenicity, virulence, and transmissibility. We previously demonstrated the co-circulation of multiple DENV genotypes in Thailand and identified a predominant genotype for each serotype. In this study, we performed a comparative analysis of the complete genomic sequences of 28 DENV-3 predominant genotype II strains previously collected during different DENV-3 epidemics in Thailand from 1973 to 2001 with the goal to define mutations that might correlate with virulence, transmission frequency, and epidemiological impact. The results revealed (1) 37 amino acid and six nucleotide substitutions adopted and fixed in the virus genome after their initial substitutions over nearly 30-year-sampling period, (2) the presence of more amino acid and nucleotide substitutions in recent virus isolates compared with earlier isolates, (3) six amino acid substitutions in capsid (C), pre-membrane (prM), envelope (E), and nonstructural (NS) proteins NS4B and NS5, which appeared to be associated with periods of high DENV-3 epidemic activity, (4) the highest degree of conservation in C, NS2B and the 5'-untranslated region (UTR), and (5) the highest percentage of amino acid substitutions in NS2A protein. C1 [Zhang, Aimee] Walter Reed Army Inst Res, Sci & Engn Apprentice Program, Silver Spring, MD 20910 USA. [Chinnawirotpisan, Piyawan; Zhang, Chunlin] US Army Med Component Armed Forces Res Inst Med S, Dept Virol, Bangkok, Thailand. [Tang, Yuxin; Zhou, Yanfei; Lynch, Julia; Thomas, Stephen; Putnak, Robert; Zhang, Chunlin] Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD 20910 USA. [Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. RP Zhang, CL (reprint author), Walter Reed Army Inst Res, Div Viral Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM chunlin.zhang@us.army.mil FU US Military Infectious Disease Research Program at Fort Detrick, Maryland, USA; Science and Engineering Apprentice Program (SEAP); George Washington University/Walter Reed Army Institute of Research FX We thank our field unit, Department of Virology, AFRIMS, Bangkok, Thailand for sample characterization and storage as well as information record; and the doctors and nurses of QSNICH/AFRIMS for sample collection and clinical grading. This research was supported by the US Military Infectious Disease Research Program at Fort Detrick, Maryland, USA and the Science and Engineering Apprentice Program (SEAP) sponsored by George Washington University/Walter Reed Army Institute of Research. NR 35 TC 0 Z9 0 U1 1 U2 9 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0920-8569 J9 VIRUS GENES JI Virus Genes PD APR PY 2013 VL 46 IS 2 BP 203 EP 218 DI 10.1007/s11262-012-0720-2 PG 16 WC Genetics & Heredity; Virology SC Genetics & Heredity; Virology GA 116KI UT WOS:000316881000001 PM 22411105 ER PT J AU Weatherless, RA Fedele, PD Kehring, KL Letowski, TR AF Weatherless, Rachel A. Fedele, Paul D. Kehring, Kathy L. Letowski, Tomasz R. TI The Effects of Simulated Hearing Loss on Speech Recognition and Walking Navigation SO HUMAN FACTORS LA English DT Article DE speech; hearing; walking; navigation; hearing loss; executive attention; task interference; dual independent tasks ID AGE-RELATED DIFFERENCES; DUAL-TASK INTERFERENCE; STOPS WALKING; PREDICTOR; ATTENTION; TALKING; FALLS; PERFORMANCE; PEOPLE; ADULTS AB Objective: The objective was to assess whether a concurrent but independent navigation task exacerbates the effects of hearing loss on speech recognition and whether hearing loss degrades performance of the navigation task during the concurrent but independent listening task. Background: Navigation performance and speech comprehension both decrease when a driver follows hard-to-hear concurrent verbal instructions. It remains unknown how much both tasks would be affected when performed concurrently, if tasks were independent. Method: Participants performed a listening task by responding to Callsign Acquisition Test (CAT) stimuli at three simulated hearing levels. For each hearing level, one trial was performed with the participant standing still and another trial was performed while navigating a path in a virtual environment using a handheld map. In one more trial, participants navigated a path with no CAT. The proportion of call signs correctly repeated and the total time required to walk the path were measured. Results: CAT scores showed an expected negative effect of hearing loss. Concurrent navigation produced an even larger decrease in CAT score. Hearing loss caused a slight but not significant decrease in navigation task performance. Conclusion: A person with hearing loss may communicate less effectively while walking than predicted on the basis of hearing loss alone. The hearing loss, however, does not significantly decrease walking performance in a simple navigation task. Application: Obtained results may guide soldier performance modeling and requirements for communication systems used during physical activity when a soldier's hearing becomes compromised during dismounted combat operations. C1 [Weatherless, Rachel A.; Fedele, Paul D.; Kehring, Kathy L.] USA, Res Lab, Aberdeen Proving Ground, MD USA. [Letowski, Tomasz R.] USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA. RP Fedele, PD (reprint author), ARL HRED, Attn RDRL HRS D, 520 Mulberry Point Rd, Aberdeen Proving Ground, MD 21005 USA. EM paul.d.fedele.civ@mail.mil NR 40 TC 0 Z9 0 U1 0 U2 6 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0018-7208 J9 HUM FACTORS JI Hum. Factors PD APR PY 2013 VL 55 IS 2 BP 285 EP 297 DI 10.1177/0018720812453465 PG 13 WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Behavioral Sciences; Engineering; Psychology GA 112YY UT WOS:000316632700004 PM 23691825 ER PT J AU Blue, M McBride, M Weatherless, R Letowski, T AF Blue, Misty McBride, Maranda Weatherless, Rachel Letowski, Tomasz TI Impact of a Bone Conduction Communication Channel on Multichannel Communication System Effectiveness SO HUMAN FACTORS LA English DT Article DE multichannel radio communication; bone conduction; speech intelligibility ID BINAURAL LOUDNESS SUMMATION; SPEECH-RECEPTION THRESHOLD; SPATIAL SEPARATION; LEVEL DIFFERENCES; AUDIO DISPLAYS; INTELLIGIBILITY; NOISE; LOCALIZATION; RECOGNITION; HEARING AB Objective: In this study, the impact of including a bone conduction transducer in a three-channel spatialized communication system was investigated. Background: Several military and security forces situations require concurrent listening to three or more radio channels. In such radio systems, spatial separation between three concurrent radio channels can be achieved by delivering separate signals to the left and right earphone independently and both earphones simultaneously. This method appears to be effective; however, the use of bone conduction as one channel may provide both operational and performance benefits. Method: Three three-channel communication systems were used to collect speech intelligibility data from 18 listeners (System 1, three loudspeakers; System 2, stereo headphones; System 3, stereo headphones and a bone conduction vibrator). Each channel presented signals perceived to originate from separate locations. Volunteers listened to three sets of competing sentences and identified a number, color, and object spoken in the target sentence. Each listener participated in three trials (one per system). Each trial consisted of 48 competing sentence sets. Results: Systems 2 and 3 were more intelligible than System 1. Systems 2 and 3 were overall equally intelligible; however, the intelligibility of all three channels was significantly more balanced in System 3. Conclusion: Replacing an air conduction transducer with a bone conduction transducer in a multichannel audio device can provide a more effective and balanced simultaneous monitoring auditory environment. Application: These results have important design and implementation implications for spatial auditory communication equipment. C1 [Blue, Misty] Wright State Univ, Dept Biomed Ind & Human Factors Engn, Dayton, OH 45435 USA. [McBride, Maranda] N Carolina Agr & Tech State Univ, Sch Business & Econ, Greensboro, NC USA. [Weatherless, Rachel] USA, Res Lab, Aberdeen Proving Ground, MD USA. [Letowski, Tomasz] USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA. RP McBride, M (reprint author), NC A&T State Univ, Dept Management, 1601 E Market St, Greensboro, NC 27411 USA. EM mcbride@ncat.edu NR 43 TC 1 Z9 1 U1 1 U2 12 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0018-7208 J9 HUM FACTORS JI Hum. Factors PD APR PY 2013 VL 55 IS 2 BP 346 EP 355 DI 10.1177/0018720812460247 PG 10 WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Behavioral Sciences; Engineering; Psychology GA 112YY UT WOS:000316632700009 PM 23691830 ER PT J AU Miranda, LE Killgore, KJ AF Miranda, L. E. Killgore, K. J. TI Entrainment of shovelnose sturgeon by towboat navigation in the Upper Mississippi River SO JOURNAL OF APPLIED ICHTHYOLOGY LA English DT Article ID ABUNDANCE; MORTALITY; HARVEST; FISHES; SYSTEM; RATES; POPULATIONS; PROPELLERS AB Estimated number of shovelnose sturgeonScaphirhynchus platorynchusimpacted annually by towboat entrainment in navigation pools of the Upper Mississippi River were compared against estimates of fishery harvest and ambient population densities to evaluate the relevance of entrainment at the population level. Mean number of sturgeon entrained per kilometer of navigation was estimated at 0.02, and mean number entrained annually considering towboat traffic was estimated at 0.38sturgeon/ha. Losses associated with entrainment were mostly lower than fishery harvest, although differences were not large. The two sources of mortality combined could potentially reduce themature adult population to a level where it no longer has the reproductive capacity to replenish itself. Thus, through a combination of entrainment and fishing mortality shovelnose sturgeon may be looming near unsustainable population levels. These estimates are preliminary considering the many uncertainties associated with quantifying entrainment and its effects. Additional research is needed not only to derive better estimates, but also to develop options for managing entrainment. C1 [Miranda, L. E.] US Geol Survey, Mississippi Cooperat Fish & Wildlife Res Unit, Mississippi State, MS 39762 USA. [Killgore, K. J.] USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Miranda, LE (reprint author), US Geol Survey, Mississippi Cooperat Fish & Wildlife Res Unit, POB 9691, Mississippi State, MS 39762 USA. EM smiranda@usgs.gov FU U.S. Army Corps of Engineers, Rock Island District FX This study was funded by the U.S. Army Corps of Engineers, Rock Island District, and conducted by the Environmental Laboratory, Engineer Research and Development Center. Technical support was provided by Mark Cornish and Thomas Keevin, U.S. Army Corps of Engineers. Q. Phelps, S. Riffel, H. Schramm, and I. Vining provided helpful reviews. Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. Government. Permission to publish this document was given by the Chief of Engineers, U.S. Army Corps of Engineers. NR 40 TC 3 Z9 3 U1 0 U2 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0175-8659 J9 J APPL ICHTHYOL JI J. Appl. Ichthyol. PD APR PY 2013 VL 29 IS 2 BP 316 EP 322 DI 10.1111/jai.12132 PG 7 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA 107NH UT WOS:000316223900003 ER PT J AU Milillo, M Kwak, YI Snesrud, E Waterman, PE Lesho, E McGann, P AF Milillo, Michael Kwak, Yoon I. Snesrud, Erik Waterman, Paige E. Lesho, Emil McGann, Patrick TI Rapid and Simultaneous Detection of bla(KPC) and bla(NDM) by Use of Multiplex Real-Time PCR SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID CARBAPENEMASE-PRODUCING ENTEROBACTERIACEAE; SPECTRUM-BETA-LACTAMASE; MODIFIED HODGE TEST; RESISTANCE; BACTERIA; ISSUES; AMPC; NDM AB The increasing incidence of carbapenem nonsusceptibility among clinically important species is of global concern. Identification of the molecular mechanisms underlying carbapenem nonsusceptibility is critical for epidemiological investigations. In this report, we describe a real-time PCR-based assay capable of simultaneously detecting bla(KPC) and bla(NDM), two of the most important carbapenemases, directly from culture in less than 90 min. The assay was validated with bla(KPC)- and bla(NDM)-carrying clinical isolates and demonstrated 100% concordance with the Carba NP test. C1 [Milillo, Michael; Kwak, Yoon I.; Snesrud, Erik; Waterman, Paige E.; Lesho, Emil; McGann, Patrick] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA. RP McGann, P (reprint author), Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA. EM patrick.mcgann@amedd.army.mil FU U.S. Army Medical Command; Defense Medical Research and Development Program FX We gratefully acknowledge the U.S. Army Medical Command and the Defense Medical Research and Development Program for providing major funding for this study. The reference strain, A. baumannii NDM2, was kindly provided by Patrice Nordmann. NR 22 TC 19 Z9 19 U1 0 U2 8 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD APR PY 2013 VL 51 IS 4 BP 1247 EP 1249 DI 10.1128/JCM.03316-12 PG 3 WC Microbiology SC Microbiology GA 107MA UT WOS:000316220400031 PM 23325823 ER PT J AU Beidleman, BA Tighiouart, H Schmid, CH Fulco, CS Muza, SR AF Beidleman, Beth A. Tighiouart, Hocine Schmid, Christopher H. Fulco, Charles S. Muza, Stephen R. TI Predictive Models of Acute Mountain Sickness after Rapid Ascent to Various Altitudes SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE HYPOXIA; HYPOBARIC HYPOXIA; MIXED MODELS; ALTITUDE; ALTITUDE SICKNESS; UNACCLIMATIZED LOWLANDERS ID PREVALENCE; EXERCISE; ILLNESS; ALPS; DETERMINANTS; WHITNEY; SUCCESS; EASTERN; SUMMIT; WOMEN AB BEIDLEMAN, B. A., H. TIGHIOUART, C. H. SCHMID, C. S. FULCO, and S. R. MUZA. Predictive Models of Acute Mountain Sickness after Rapid Ascent to Various Altitudes. Med. Sci. Sports Exerc., Vol. 45, No. 4, pp. 792-800, 2013. Purpose: Despite decades of research, no predictive models of acute mountain sickness (AMS) exist, which identify the time course of AMS severity and prevalence following rapid ascent to various altitudes. Methods: Using general linear and logistic mixed models and a comprehensive database, we analyzed 1292 AMS cerebral factor scores in 308 unacclimatized men and women who spent between 4 and 48 h at altitudes ranging from 1659 to 4501 m under experimentally controlled conditions (low and high activity). Covariates included in the analysis were altitude, time at altitude, activity level, age, body mass index, race, sex, and smoking status. Results: AMS severity increased (P < 0.05) nearly twofold (i.e., 179%) for every 1000-m increase in altitude at 20 h of exposure, peaked between 18 and 22 h of exposure, and returned to initial levels by 48 h of exposure regardless of sex or activity level. Peak AMS severity scores were 38% higher (P < 0.05) in men compared with women at 20 h of exposure. High active men and women (>50% of maximal oxygen uptake for >45 min at altitude) demonstrated a 72% increase (P < 0.05) in the odds (odds ratio, 1.72; confidence interval, 1.03-3.08) of AMS compared with low active men and women. There was also a tendency (P = 0.10) for men to demonstrate greater odds of AMS (odds ratio, 1.65; confidence interval, 0.84-3.25) compared with women. Age, body mass index, race, and smoking status were not significantly associated with AMS. Conclusions: These models provide the first quantitative estimates of AMS risk over a wide range of altitudes and time points and suggest that in addition to altitude and time at altitude, high activity increases the risk of developing AMS. In addition, men demonstrated increased severity but not prevalence of AMS. C1 [Beidleman, Beth A.; Fulco, Charles S.; Muza, Stephen R.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. [Tighiouart, Hocine; Schmid, Christopher H.] Tufts Med Ctr, Inst Clin Res & Hlth Policy Studies, Boston, MA USA. RP Beidleman, BA (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. EM beth.beidleman@us.army.mil OI Schmid, Christopher/0000-0002-0855-5313 FU US Army Medical Research and Materiel Command FX The dedicated and professional efforts of Dr. Allen Cymerman, Dr. Juli Jones, Dr. Paul Rock, Ms. Janet Staab, Mr. Vinnie Forte, Ms. Ingrid Sils, Mr. Guy Tatum, Mr. Leonard Elliot, Mr. Rob Demes, Ms. Marie Grunbeck, Mr. Sean Andrew, SSG Mark Kryskow, SSG Sarah Elliot, SSG Michael Cavallo, and SPC Miguel Fernandez supporting the collection and analysis of the data are acknowledged and greatly appreciated. The dedication and efforts of the test volunteers in completing this study are also acknowledged and appreciated. Funding was provided by the US Army Medical Research and Materiel Command. NR 42 TC 15 Z9 16 U1 1 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD APR PY 2013 VL 45 IS 4 BP 792 EP 800 DI 10.1249/MSS.0b013e31827989ec PG 9 WC Sport Sciences SC Sport Sciences GA 109ZK UT WOS:000316410600024 PM 23135373 ER PT J AU Rhodes, NR Tschopp, MA Solanki, KN AF Rhodes, N. R. Tschopp, M. A. Solanki, K. N. TI Quantifying the energetics and length scales of carbon segregation to alpha-Fe symmetric tilt grain boundaries using atomistic simulations SO MODELLING AND SIMULATION IN MATERIALS SCIENCE AND ENGINEERING LA English DT Article ID STRUCTURE-ENERGY CORRELATION; CR-1 MO STEEL; SOLUTE SEGREGATION; FCC METALS; MOLECULAR-DYNAMICS; ATOM-PROBE; DISLOCATION NUCLEATION; CARBIDE PRECIPITATION; TEMPER EMBRITTLEMENT; DOPANT SEGREGATION AB Segregation of impurities to grain boundaries (GBs) plays an important role in both the stability and macroscopic behavior of polycrystalline materials. The research objective in this work is to better characterize the energetics and length scales involved with the process of solute and impurity segregation to GBs. Molecular statics simulations are used to calculate the segregation energies for carbon within multiple substitutional and interstitial GB sites over a database of 125 symmetric tilt GBs in Fe. The simulation results show that there are two energetically favorable GB segregation processes: (1) an octahedral C atom in the lattice segregating to an interstitial GB site and (2) an octahedral C atom and a vacancy in the lattice segregating to a grain boundary substitutional site. In both cases, lower segregation energies than appear in the bulk lattice were calculated. Moreover, based on segregation energies approaching bulk values, the length scale of interaction is larger for interstitial C than for substitutional C in the GB (approximate to 5 angstrom compared to approximate to 3 angstrom from center of the GB). A subsequent data reduction and statistical representation of this dataset provides critical information about the mean segregation energy and the associated energy distributions for carbon atoms as a function of distance from the grain boundary, which quantitatively informs higher scale models with energetics and length scales necessary for capturing the segregation behavior of alloying elements and impurities in Fe. The significance of this research is the development of a methodology capable of ascertaining segregation energies over a wide range of GB character (typical of that observed in polycrystalline materials), which herein has been applied to carbon segregation to substitutional and interstitial sites in a specific class of GBs in alpha-Fe. C1 [Rhodes, N. R.; Tschopp, M. A.] Mississippi State Univ, Ctr Adv Vehicular Syst, Starkville, MS 39762 USA. [Tschopp, M. A.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Solanki, K. N.] Arizona State Univ, Sch Engn Matter Transport & Energy, Tempe, AZ 85287 USA. RP Rhodes, NR (reprint author), Mississippi State Univ, Ctr Adv Vehicular Syst, Starkville, MS 39762 USA. EM mark.a.tschopp.ctr@mail.mil RI Solanki, Kiran/E-8337-2010; Tschopp, Mark/B-1594-2008; OI Tschopp, Mark/0000-0001-8471-5035; Solanki, Kiran/0000-0002-4385-620X FU U.S. Department of Energy; National Energy Technology Laboratory [DE-FC26-02OR22910]; U.S. Department of Energy's Nuclear Energy Advanced Modeling and Simulation (NEAMS) Program at the Pacific Northwest National Laboratory [DE-AC05-76RL01830]; Office of Naval Research [N000141110793]; agency of the United States government FX MAT would like to acknowledge funding under the U.S. Department of Energy and the National Energy Technology Laboratory under Award Number DE-FC26-02OR22910 and the U.S. Department of Energy's Nuclear Energy Advanced Modeling and Simulation (NEAMS) Program at the Pacific Northwest National Laboratory, which is operated by Battelle under contract No. DE-AC05-76RL01830. KNS would like to acknowledge the support by the Office of Naval Research under contract No. N000141110793. This report was prepared as an account of work sponsored by an agency of the United States government. Neither the United States government nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise does not necessarily constitute or imply its endorsement, recommendation, or favoring by the United States government or any agency thereof. The views and opinions of authors expressed herein do not necessarily state or reflect those of the United States government or any agency thereof. Such support does not constitute an endorsement by the Department of Energy of the work or the views expressed herein. NR 92 TC 25 Z9 25 U1 2 U2 41 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0965-0393 J9 MODEL SIMUL MATER SC JI Model. Simul. Mater. Sci. Eng. PD APR PY 2013 VL 21 IS 3 AR 035009 DI 10.1088/0965-0393/21/3/035009 PG 21 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA 110OD UT WOS:000316452900009 ER PT J AU Hopkinson, SG Jennings, BM AF Hopkinson, Susan G. Jennings, Bonnie Mowinski TI Authors' Response to the Letter to RINAH Editor: Interruptions are Significantly Associated With the Frequency and Severity of Medication Errors SO RESEARCH IN NURSING & HEALTH LA English DT Letter C1 [Hopkinson, Susan G.] US Army Nurse Corps, Ctr Nursing Sci & Clin Inquiry Landstuhl Reg Med, Landstuhl, Germany. [Jennings, Bonnie Mowinski] Emory Univ, Nell Hodgson Woodruff Sch Nursing, Atlanta, GA 30322 USA. RP Hopkinson, SG (reprint author), US Army Nurse Corps, Ctr Nursing Sci & Clin Inquiry Landstuhl Reg Med, Landstuhl, Germany. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0160-6891 J9 RES NURS HEALTH JI Res. Nurs. Health PD APR PY 2013 VL 36 IS 2 BP 117 EP 119 PG 3 WC Nursing SC Nursing GA 109BA UT WOS:000316338900012 PM 23616997 ER PT J AU Song, HJ Choi, KK Lee, I Zhao, L Lamb, D AF Song, Hyeongjin Choi, K. K. Lee, Ikjin Zhao, Liang Lamb, David TI Adaptive virtual support vector machine for reliability analysis of high-dimensional problems SO STRUCTURAL AND MULTIDISCIPLINARY OPTIMIZATION LA English DT Article DE Surrogate model; Support vector machine (SVM); Sequential sampling; Virtual samples; Virtual support vector machine (VSVM); High-dimensional problem ID DESIGN OPTIMIZATION; CONTOUR ESTIMATION; MINIMIZATION; SEARCH AB In this paper, an efficient classification methodology is developed for reliability analysis while maintaining an accuracy level similar to or better than existing response surface methods. The sampling-based reliability analysis requires only the classification information-a success or a failure-but the response surface methods provide function values on the domain as their output, which requires more computational effort. The problem is even more challenging when dealing with high-dimensional problems due to the curse of dimensionality. In the newly proposed virtual support vector machine (VSVM), virtual samples are generated near the limit state function by using an approximation method. The function values are used for approximations of virtual samples to improve accuracy of the resulting VSVM decision function. By introducing the virtual samples, VSVM can overcome the deficiency in existing classification methods where only classification values are used as their input. The universal Kriging method is used to obtain virtual samples to improve the accuracy of the decision function for highly nonlinear problems. A sequential sampling strategy that chooses new samples near the limit state function is integrated with VSVM to improve the accuracy. Examples show the proposed adaptive VSVM yields better efficiency in terms of modeling and response evaluation time and the number of required samples while maintaining similar level or better accuracy, especially for high-dimensional problems. C1 [Song, Hyeongjin; Choi, K. K.] Univ Iowa, Dept Mech & Ind Engn, Coll Engn, Iowa City, IA 52242 USA. [Lee, Ikjin] Univ Connecticut, Dept Mech Engn, Storrs, CT 06269 USA. [Zhao, Liang] Schlumberger, Houston, TX 77073 USA. [Lamb, David] USA, RDECOM TARDEC, Warren, MI 48397 USA. RP Choi, KK (reprint author), Univ Iowa, Dept Mech & Ind Engn, Coll Engn, Iowa City, IA 52242 USA. EM hyesong@engineering.uiowa.edu; kkchoi@engineering.uiowa.edu; ilee@engr.uconn.edu; lzhao01@slb.com; david.lamb@us.army.mil RI Lee, IkJin/I-4722-2013; Choi, Kyung/B-1512-2008 OI Choi, Kyung/0000-0003-2384-6220 FU ARO [W911NF-09-1-0250]; Automotive Research Center; U.S. Army TARDEC; World Class University Program through the National Research Foundation of Korea (NRF); Ministry of Education, Science and Technology [R32-2008-000-10161-0] FX The research is jointly supported by the ARO Project W911NF-09-1-0250 and the Automotive Research Center, which is sponsored by the U.S. Army TARDEC. The research is also partially supported by the World Class University Program through the National Research Foundation of Korea (NRF) grant funded by the Ministry of Education, Science and Technology (Grant Number R32-2008-000-10161-0 in 2009). These supports are greatly appreciated. NR 44 TC 12 Z9 13 U1 2 U2 26 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1615-147X J9 STRUCT MULTIDISCIP O JI Struct. Multidiscip. Optim. PD APR PY 2013 VL 47 IS 4 BP 479 EP 491 DI 10.1007/s00158-012-0857-6 PG 13 WC Computer Science, Interdisciplinary Applications; Engineering, Multidisciplinary; Mechanics SC Computer Science; Engineering; Mechanics GA 113AO UT WOS:000316638300001 ER PT J AU Yanovich, R Evans, RK Friedman, E Moran, DS AF Yanovich, Ran Evans, Rachel K. Friedman, Eitan Moran, Daniel S. TI Bone Turnover Markers Do Not Predict Stress Fracture in Elite Combat Recruits SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article ID BIOCHEMICAL MARKERS; MILITARY RECRUITS; RISK-FACTORS; WOMEN AB With bone resorption rates greater than formation, stress fracture pathogenesis plausibly involves bone remodeling imbalance. If this is the case, one would anticipate serum levels of bone turnover markers would be higher in patients with stress fractures than in those without. We therefore asked whether: (1) bone turnover markers differ between soldiers who will or will not have stress fractures during basic training; (2) bone turnover markers change during basic training; and (3) serial bone formation or bone resorption markers differ between subjects with and without stress fractures during basic training? We performed serial determinations of serum bone formation (bone alkaline phosphatase [BAP] and procollagen type I amino-terminal propeptide [PINP]), and resorption (tartrate-resistant acid phosphatase [TRAP5b] and cross-linked collagen telopeptide [CTx]) biomarkers, measured at 2- to 4-week intervals (during 18 weeks) in 69 male soldiers in the Israeli Defense Forces during elite basic training. Twenty-two soldiers (32%) were diagnosed with stress fractures. The mean training week at diagnosis was 8.0 +/- A 2.0 weeks. We observed no differences in bone turnover markers between soldiers with and without stress fractures. During basic training, the mean values of all subjects for bone turnover markers (BAP, PINP, and CTx) changed in comparison to their mean levels at induction (43.9 versus 37.3 mu g/L, 110.4 versus 78.0 mu g/L, 1.4 versus 1.1 ng/mL, respectively). We found no changes in bone formation and resorption markers between subjects with and without stress fractures. These specific bone turnover markers cannot be considered as either diagnostic or predictive tools for stress fracture detection in young male military recruits. Level II prognostic study. See the Guidelines for Authors for a complete description of levels of evidence. C1 [Yanovich, Ran; Moran, Daniel S.] IDF Med Corps, Inst Mil Physiol, Tel Hashomer, Israel. [Yanovich, Ran; Moran, Daniel S.] Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. [Evans, Rachel K.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Friedman, Eitan] Chaim Sheba Med Ctr, Susanne Levy Gertner Oncogenet Unit, IL-52621 Tel Hashomer, Israel. [Friedman, Eitan] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel. [Moran, Daniel S.] Ariel Univ, Ctr Samaria, Ariel, Israel. RP Moran, DS (reprint author), Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. EM dmoran@sheba.health.gov.il FU United States Army FX The institution of one of the authors (DSM) has received, during the study period, funding of USD 10,000-USD 100,000 from the United States Army. NR 28 TC 3 Z9 3 U1 1 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0009-921X J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD APR PY 2013 VL 471 IS 4 BP 1365 EP 1372 DI 10.1007/s11999-012-2727-3 PG 8 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 097YW UT WOS:000315510400046 PM 23239391 ER PT J AU Ely, BR Sollanek, KJ Cheuvront, SN Lieberman, HR Kenefick, RW AF Ely, Brett R. Sollanek, Kurt J. Cheuvront, Samuel N. Lieberman, Harris R. Kenefick, Robert W. TI Hypohydration and acute thermal stress affect mood state but not cognition or dynamic postural balance SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE Thermal sensation; Skin temperature; Profile of mood states; Postural stability; Dehydration ID INDUCED BODY-SWAY; HEAT-STRESS; PRESSOR INPUT; HUMAN FEET; PERFORMANCE; DEHYDRATION; EXERCISE; HYDRATION; HYPOTHERMIA; TEMPERATE AB Equivocal findings have been reported in the few studies that examined the impact of ambient temperature (T (a)) and hypohydration on cognition and dynamic balance. The purpose of this study was to determine the impact of acute exposure to a range of ambient temperatures (T (a) 10-40 A degrees C) in euhydration (EUH) and hypohydration (HYP) states on cognition, mood and dynamic balance. Thirty-two men (age 22 +/- A 4 years, height 1.80 +/- A 0.05 m, body mass 85.4 +/- A 10.8 kg) were grouped into four matched cohorts (n = 8), and tested in one of the four T (a) (10, 20, 30, 40 A degrees C) when EUH and HYP (-4 % body mass via exercise-heat exposure). Cognition was assessed using psychomotor vigilance, 4-choice reaction time, matching to sample, and grammatical reasoning. Mood was evaluated by profile of mood states and dynamic postural balance was tested using a Biodex Balance System. Thermal sensation (TS), core (T (core)) and skin temperature (T (sk)) were obtained throughout testing. Volunteers lost -4.1 +/- A 0.4 % body mass during HYP. T (sk) and TS increased with increasing T (a), with no effect of hydration. Cognitive performance was not altered by HYP or thermal stress. Total mood disturbance (TMD), fatigue, confusion, anger, and depression increased during HYP at all T (a). Dynamic balance was unaffected by HYP, but 10 A degrees C exposure impaired balance compared to all other T (a). Despite an increase in TMD during HYP, cognitive function was maintained in all testing environments, demonstrating cognitive resiliency in response to body fluid deficits. Dynamic postural stability at 10 A degrees C appeared to be hampered by low-grade shivering, but was otherwise maintained during HYP and thermal stress. C1 [Ely, Brett R.; Sollanek, Kurt J.; Cheuvront, Samuel N.; Lieberman, Harris R.; Kenefick, Robert W.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Kenefick, RW (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM robert.kenefick@us.army.mil NR 39 TC 6 Z9 7 U1 2 U2 33 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1439-6319 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD APR PY 2013 VL 113 IS 4 BP 1027 EP 1034 DI 10.1007/s00421-012-2506-6 PG 8 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 106EI UT WOS:000316124900023 PM 23064870 ER PT J AU Abrudan, J Ramalho-Ortigao, M O'Neil, S Stayback, G Wadsworth, M Bernard, M Shoue, D Emrich, S Lawyer, P Kamhawi, S Rowton, ED Lehane, MJ Bates, PA Valenzeula, JG Tomlinson, C Appelbaum, E Moeller, D Thiesing, B Dillon, R Clifton, S Lobo, NF Wilson, RK Collins, FH McDowell, MA AF Abrudan, J. Ramalho-Ortigao, M. O'Neil, S. Stayback, G. Wadsworth, M. Bernard, M. Shoue, D. Emrich, S. Lawyer, P. Kamhawi, S. Rowton, E. D. Lehane, M. J. Bates, P. A. Valenzeula, J. G. Tomlinson, C. Appelbaum, E. Moeller, D. Thiesing, B. Dillon, R. Clifton, S. Lobo, N. F. Wilson, R. K. Collins, F. H. McDowell, M. A. TI The characterization of the Phlebotomus papatasi transcriptome SO INSECT MOLECULAR BIOLOGY LA English DT Review DE sand fly; phebotomine; transcriptome ID PROPHENOLOXIDASE-ACTIVATING SYSTEM; MOSQUITO ANOPHELES-GAMBIAE; INNATE IMMUNE-RESPONSE; BETA-1,3-GLUCAN RECOGNITION PROTEIN; MULTIPLE SEQUENCE ALIGNMENT; LUTZOMYIA-LONGIPALPIS; AEDES-AEGYPTI; DROSOPHILA-MELANOGASTER; PERITROPHIC MATRIX; BOMBYX-MORI AB As important vectors of human disease, phlebotomine sand flies are of global significance to human health, transmitting several emerging and re-emerging infectious diseases. The most devastating of the sand fly transmitted infections are the leishmaniases, causing significant mortality and morbidity in both the Old and New World. Here we present the first global transcriptome analysis of the Old World vector of cutaneous leishmaniasis, Phlebotomus papatasi (Scopoli) and compare this transcriptome to that of the New World vector of visceral leishmaniasis, Lutzomyia longipalpis. A normalized cDNA library was constructed using pooled mRNA from Phlebotomus papatasi larvae, pupae, adult males and females fed sugar, blood, or blood infected with Leishmania major. A total of 47615 generated sequences was cleaned and assembled into 17120 unique transcripts. Of the assembled sequences, 50% (8837 sequences) were classified using Gene Ontology (GO) terms. This collection of transcripts is comprehensive, as demonstrated by the high number of different GO categories. An in-depth analysis revealed 245 sequences with putative homology to proteins involved in blood and sugar digestion, immune response and peritrophic matrix formation. Twelve of the novel genes, including one trypsin, two peptidoglycan recognition proteins (PGRP) and nine chymotrypsins, have a higher expression level during larval stages. Two novel chymotrypsins and one novel PGRP are abundantly expressed upon blood feeding. This study will greatly improve the available genomic resources for P.papatasi and will provide essential information for annotation of the full genome. C1 [Abrudan, J.; Ramalho-Ortigao, M.; Stayback, G.; Wadsworth, M.; Bernard, M.; Shoue, D.; Lobo, N. F.; Collins, F. H.; McDowell, M. A.] Univ Notre Dame, Dept Biol Sci, Eck Inst Global Hlth, Notre Dame, IN 46556 USA. [O'Neil, S.; Emrich, S.] Univ Notre Dame, Notre Dame, IN 46556 USA. [Lawyer, P.] NIAID, Intracellular Parasite Biol Sect, Parasit Dis Lab, NIH, Rockville, MD USA. [Kamhawi, S.; Valenzeula, J. G.] NIAID, Vector Mol Biol Sect, Lab Malaria & Vector Res, NIH, Rockville, MD USA. [Rowton, E. D.] Walter Reed Army Inst Res, Entomol Program, Silver Spring, MD USA. [Lehane, M. J.] Univ Liverpool, Liverpool Sch Trop Med, Vector Grp, Liverpool L3 5QA, Merseyside, England. [Bates, P. A.; Dillon, R.] Univ Lancaster, Div Biomed & Life Sci, Fac Hlth & Med, Lancaster, England. [Tomlinson, C.; Appelbaum, E.; Moeller, D.; Thiesing, B.; Clifton, S.; Wilson, R. K.] Washington Univ, Genome Inst, St Louis, MO USA. RP McDowell, MA (reprint author), Univ Notre Dame, Dept Biol Sci, Eck Inst Global Hlth, Notre Dame, IN 46556 USA. EM mcdowell.11@nd.edu OI Bates, Paul/0000-0001-6861-5421; Dillon, Rod/0000-0002-3551-0030 FU National Human Genome Research Institute; Defense Advanced Research Projects Agency [W911NF0410380]; Telemedicine and Advanced Technology Research Center [W81XWH-10-1-0085]; VectorBase [NIH/NIAID HHSN72200900039C]; NSF MRI Grant [DBI-0420980] FX This project was supported by the National Human Genome Research Institute and in part by an award from the Defense Advanced Research Projects Agency (#W911NF0410380) and Telemedicine and Advanced Technology Research Center (#W81XWH-10-1-0085) to Mary Ann McDowell. This project was also supported by VectorBase (NIH/NIAID HHSN72200900039C. The assembly was performed on the Notre Dame Biocomplexity Cluster (University of Notre Dame, Notre Dame, IN, USA) supported in part by NSF MRI Grant No. DBI-0420980. BLAST searches were performed on the Biocompute server at Notre Dame. NR 109 TC 6 Z9 6 U1 1 U2 53 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0962-1075 J9 INSECT MOL BIOL JI Insect Mol. Biol. PD APR PY 2013 VL 22 IS 2 BP 211 EP 232 DI 10.1111/imb.12015 PG 22 WC Biochemistry & Molecular Biology; Entomology SC Biochemistry & Molecular Biology; Entomology GA 102OO UT WOS:000315854100007 PM 23398403 ER PT J AU Martinez, O Johnson, JC Honko, A Yen, B Shabman, RS Hensley, LE Olinger, GG Basler, CF AF Martinez, Osvaldo Johnson, Joshua C. Honko, Anna Yen, Benjamin Shabman, Reed S. Hensley, Lisa E. Olinger, Gene G. Basler, Christopher F. TI Ebola Virus Exploits a Monocyte Differentiation Program To Promote Its Entry SO JOURNAL OF VIROLOGY LA English DT Article ID LAKE-VICTORIA-MARBURGVIRUS; HUMAN DENDRITIC CELLS; NIEMANN-PICK C1; HEMORRHAGIC-FEVER; DC-SIGN; MACROPHAGE DIFFERENTIATION; ZAIRE-EBOLAVIRUS; BLOOD MONOCYTES; MUCIN DOMAIN; VIRAL ENTRY AB Antigen-presenting cells (APCs) are critical targets of Ebola virus (EBOV) infection in vivo. However, the susceptibility of monocytes to infection is controversial. Studies indicate productive monocyte infection, and yet monocytes are also reported to be resistant to EBOV GP-mediated entry. In contrast, monocyte-derived macrophages and dendritic cells are permissive for both EBOV entry and replication. Here, freshly isolated monocytes are demonstrated to indeed be refractory to EBOV entry. However, EBOV binds monocytes, and delayed entry occurs during monocyte differentiation. Cultured monocytes spontaneously downregulate the expression of viral entry restriction factors such as interferon-inducible transmembrane proteins, while upregulating the expression of critical EBOV entry factors cathepsin B and NPC1. Moreover, these processes are accelerated by EBOV infection. Finally, ectopic expression of NPC1 is sufficient to rescue entry into an undifferentiated, normally nonpermissive monocytic cell line. These results define the molecular basis for infection of APCs and suggest means to limit APC infection. C1 [Martinez, Osvaldo; Yen, Benjamin; Shabman, Reed S.; Basler, Christopher F.] Icahn Sch Med Mt Sinai, New York, NY USA. [Johnson, Joshua C.; Honko, Anna; Olinger, Gene G.] USA, Med Res Inst Infect Dis, Ft Detrick, MD USA. [Hensley, Lisa E.] US FDA, Med Countermeasures Initiat, OCS, OCET, Silver Spring, MD USA. RP Basler, CF (reprint author), Icahn Sch Med Mt Sinai, New York, NY USA. EM chris.basler@mssm.edu OI Olinger, Gene/0000-0001-7338-0292; Johnson, Joshua/0000-0002-5677-3841; Martinez, Osvaldo/0000-0001-7335-4342; Honko, Anna/0000-0001-9165-148X; Shabman, Reed/0000-0003-3272-3484 FU National Institutes of Health [R01AI059536, R21AI097568, AI057158]; U.S. Army [W81XWH-10-1-0683]; NIH [5F32AI084453-02] FX This study was supported in part by National Institutes of Health grants R01AI059536, R21AI097568, and AI057158 (Northeast Biodefense Center-Lipkin), U.S. Army grant W81XWH-10-1-0683 to C.F.B., and NIH fellowship 5F32AI084453-02 to R.S.S. NR 79 TC 15 Z9 15 U1 0 U2 27 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD APR PY 2013 VL 87 IS 7 BP 3801 EP 3814 DI 10.1128/JVI.02695-12 PG 14 WC Virology SC Virology GA 103ZC UT WOS:000315957100018 PM 23345511 ER PT J AU Brown, DJ Swannack, TM Forstner, MRJ AF Brown, Donald J. Swannack, Todd M. Forstner, Michael R. J. TI Predictive Models for Calling and Movement Activity of the Endangered Houston Toad SO AMERICAN MIDLAND NATURALIST LA English DT Article ID DETECTION PROBABILITIES; BUFO-HOUSTONENSIS; AMPHIBIAN DECLINE; NATIONAL-PARK; MOON PHASE; POPULATION; FRAGMENTATION; HYBRIDIZATION; PERSPECTIVE; ABUNDANCE AB Anuran monitoring has increased in recent years in response to global population declines. Delineating abiotic factors that influence anuran activity patterns is important for maximizing monitoring and research efficiency. The Houston toad (Bufo (Anaxyrus) houstonensis) was the first amphibian to be listed as federally endangered in the United States, and populations have continued to decline since it was listed. In this study we investigated the influence of six abiotic factors and one biotic factor on Houston toad calling activity and terrestrial movement in the Lost Pines ecoregion of Texas. Using program PRESENCE, we treated the factors as survey-specific covariates to determine their influence on detection probabilities, and thus presumably activity levels. We found that average daily absolute humidity, average daily wind speed, and presence/absence of Houston toad calling activity the previous night were important factors influencing calling activity, and average daily absolute humidity and detection/non-detection of Houston toad movement activity the previous night were important factors influencing movement activity. We also found that multiple survey years were necessary to delineate influential factors for this species, a result with implications for activity patterns of other rare anurans. The results of this study contribute to our understanding of amphibian activity patterns, and will improve the efficiency of future Houston toad research and monitoring efforts. C1 [Brown, Donald J.; Forstner, Michael R. J.] Texas State Univ San Marcos, Dept Biol, San Marcos, TX 78666 USA. [Swannack, Todd M.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Brown, DJ (reprint author), Texas State Univ San Marcos, Dept Biol, 601 Univ Dr, San Marcos, TX 78666 USA. EM db1300@txstate.edu FU Boy Scouts of America; Texas Parks and Wildlife Department [SPR-0102-191]; United States Fish and Wildlife Service [TE 039544-0] FX We thank all of the individuals who assisted with call surveys and trapping for this study, particularly J. Jackson and J. Bell. The Boy Scouts of America provided funding and access to the GLR and we are grateful for their support. Primary funding and research permits were provided by the Texas Parks and Wildlife Department (permit SPR-0102-191), and the United States Fish and Wildlife Service (permit TE 039544-0). This research was approved by the Texas State University-San Marcos Institutional Animal Care and Use Committee (0810_0208_11). Two anonymous reviewers provided comments that greatly enhanced the quality of this manuscript. NR 67 TC 5 Z9 5 U1 1 U2 6 PU AMER MIDLAND NATURALIST PI NOTRE DAME PA UNIV NOTRE DAME, BOX 369, ROOM 295 GLSC, NOTRE DAME, IN 46556 USA SN 0003-0031 EI 1938-4238 J9 AM MIDL NAT JI Am. Midl. Nat. PD APR PY 2013 VL 169 IS 2 BP 303 EP 321 PG 19 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA AK1VU UT WOS:000338206900005 ER PT J AU Burr, JE Roberts, TA Bucci, JR AF Burr, Jean E. Roberts, Timothy A. Bucci, Jay R. TI Dependent Adolescent Pregnancy Rates and Risk Factors for Pregnancy in the Military Health Care System SO MILITARY MEDICINE LA English DT Article AB Background: We sought to determine the pregnancy rate of U.S. military-dependent adolescents enrolled in the military healthcare system. Methods: We examined the age and insurance status of dependent adolescents, ages 12 to 23, and determined the incidence of new pregnancies in the military healthcare system from 2006 to 2010 in San Antonio, Texas. Adolescents not enrolled or only recently enrolled in TRICARE Prime at the time of pregnancy were analyzed separately. A Cox-Proportional Hazards model was used to determine risk factors for pregnancy (relationship to sponsor, age, and contraceptive prescription). Results: 444 pregnancies were diagnosed among the 12,417 eligible subjects. For adolescents with continuous enrollment in TRICARE Prime, the pregnancy rate was 9.67/1,000 woman-years at risk, much lower than the national average. Cox-Proportional Hazards analysis showed age group (15-19 years), and history of oral contraceptive prescription were associated with a higher pregnancy rate. 59% of pregnancies occurred in women not enrolled or only briefly enrolled in TRICARE Prime at the time of pregnancy. Conclusion: Dependent daughters enrolled in TRICARE Prime had a very low pregnancy rate. The majority of pregnancies occurred in adolescents not enrolled in TRICARE Prime at the time of pregnancy diagnosis, suggesting many adolescents sought health insurance after pregnancy was diagnosed. C1 [Burr, Jean E.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. [Roberts, Timothy A.] Naval Med Ctr San Diego, Dept Pediat, San Diego, CA 92134 USA. [Bucci, Jay R.] Brooke Army Med Ctr, Dept Clin Invest, San Antonio, TX 78234 USA. RP Burr, JE (reprint author), Tripler Army Med Ctr, Dept Pediat, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 10 TC 1 Z9 1 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD APR PY 2013 VL 178 IS 4 BP 412 EP 415 DI 10.7205/MILMED-D-12-00461 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA AN7TY UT WOS:000340805100012 PM 23707826 ER PT J AU Colthirst, PM Berg, RG DeNicolo, P Simecek, JW AF Colthirst, Paul M. Berg, Rosann G. DeNicolo, Philip Simecek, John W. TI Operational Cost Analysis of Dental Emergencies for Deployed US Army Personnel During Operation Iraqi Freedom SO MILITARY MEDICINE LA English DT Article ID RATES AB The documentation of dental emergency (DE) rates in past global conflicts has been well established; however, little is known about wartime DE costs on the battlefield. Using DEs as an example for decreased combat effectiveness, this article analyzes the cost of treating DEs in theater, both in terms of fixed and variable costs, and also highlighted the difficulties that military units experience when faced with degradation of combat manpower because of DEs. The study found that Dental-Disease and Non-Battle Injury cost the U.S. Army a total of $21.4M between July 1, 2009 and June 30, 2010, and $21.9M between July 1, 2010 and June 30, 2011. The results also revealed that approximately 32% of DE required follow-up treatment over the 2-year period, which increased the costs associated with a DE over time. Understanding the etiology and cost of DE cases, military dental practitioners will be better equipped to provide oral health instructions and preventive measures before worldwide deployments. C1 [Colthirst, Paul M.; Berg, Rosann G.; DeNicolo, Philip] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Simecek, John W.] Naval Med Res Unit San Antonio, Ft Sam Houston, TX 78234 USA. RP Colthirst, PM (reprint author), US Army, Inst Surg Res, 3650 Chambers Pass,Bldg 3610, Ft Sam Houston, TX 78234 USA. FU U.S. Army Medical Research and Materiel Command Institutional Review Board; U.S. Army Institute of Surgical Research [H-11-037] FX The authors would especially like to thank COL Steven Eikenberg, Department of Dental Services at the U.S. Army Medical Department Center and School, and SFC Carlotta Trotman, NCOIC, Dental Clinic, Aberdeen Proving Ground, for their invaluable contributions as consultants. This study was conducted and funded under a protocol reviewed and approved by the U.S. Army Medical Research and Materiel Command Institutional Review Board and in accordance with the approved protocol office (U.S. Army Institute of Surgical Research Protocol No. H-11-037). NR 15 TC 2 Z9 2 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD APR PY 2013 VL 178 IS 4 BP 427 EP 431 DI 10.7205/MILMED-D-12-00431 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA AN7TY UT WOS:000340805100015 PM 23707829 ER PT J AU Pinsker, JE McBayne, K Edwards, M Jensen, K Crudo, DF Bauer, AJ AF Pinsker, Jordan E. McBayne, Krista Edwards, Mary Jensen, Kirk Crudo, David F. Bauer, Andrew J. TI Transient Hypothyroidism in Premature Infants After Short-term Topical Iodine Exposure: An Avoidable Risk? SO PEDIATRICS AND NEONATOLOGY LA English DT Article DE hypothyroidism; iodine; infant AB Studies in preterm infants have shown that prolonged treatment with topical iodine (multiple doses, often over multiple days) can transiently suppress thyroid function. However, it is uncertain if topical iodine exposure for very short periods of time can cause significant changes in thyroid function. We report two cases of transient hypothyroidism in preterm infants after short-term exposure to topical iodine during surgical preparation, and review their clinical and laboratory findings before and after iodine exposure. We conclude that premature infants are at risk of developing transient hypothyroidism in response to a single, short-term exposure to topical iodine, even in iodine-sufficient geographical areas. We advise monitoring of thyroid function in these infants after iodine exposure, as treatment with levothyroxine may be needed for a limited duration to prevent the sequelae of untreated hypothyroidism. Consideration of using alternative cleansing agents is also advised. Copyright (C) 2012, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. All rights reserved. C1 [Pinsker, Jordan E.; McBayne, Krista] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. [Edwards, Mary] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. [Jensen, Kirk; Bauer, Andrew J.] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. [Jensen, Kirk; Bauer, Andrew J.] Walter Reed Natl Mil Med Ctr, Dept Pediat, Bethesda, MD USA. [Crudo, David F.] Wake Forest Univ, Bowman Gray Sch Med, Dept Pediat, Winston Salem, NC 27103 USA. [Bauer, Andrew J.] Childrens Hosp Philadelphia, Div Endocrinol, Thyroid Ctr, Philadelphia, PA USA. RP Pinsker, JE (reprint author), Tripler Army Med Ctr, Dept Pediat, Mail Code MCIK PE 1,Jarrett White Rd, Honolulu, HI 96859 USA. EM jordan.pinsker@us.army.mil OI Pinsker, Jordan/0000-0003-4080-9034 NR 26 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER TAIWAN PI TAIPEI PA RM N-412, 4F, CHIA HSIN BUILDING 11, NO 96, ZHONG SHAN N ROAD SEC 2, TAIPEI, 10449, TAIWAN SN 1875-9572 J9 PEDIATR NEONATOL JI Pediatr. Neonatol. PD APR PY 2013 VL 54 IS 2 BP 128 EP 131 DI 10.1016/j.pedneo.2012.10.005 PG 4 WC Pediatrics SC Pediatrics GA V40NG UT WOS:000209484700012 PM 23590958 ER PT J AU Fahrenfeld, N Zoeckler, J Widdowson, MA Pruden, A AF Fahrenfeld, Nicole Zoeckler, Jeffrey Widdowson, Mark A. Pruden, Amy TI Effect of biostimulants on 2,4,6-trinitrotoluene (TNT) degradation and bacterial community composition in contaminated aquifer sediment enrichments SO BIODEGRADATION LA English DT Article DE 2,4,6-Trinitrotoluene; Energetic compounds; Nitroaromatic; Bacterial community; Biostimulation; Biodegradation ID PSEUDOMONAS-PUTIDA JLR11; MICROBIAL COMMUNITY; CLOSTRIDIUM-ACETOBUTYLICUM; SOIL; EXPLOSIVES; BIOTRANSFORMATION; TRINITROTOLUENE; BIOREMEDIATION; BIODEGRADATION; MINERALIZATION AB 2,4,6-Trinitrotoluene (TNT) is a toxic and persistent explosive compound occurring as a contaminant at numerous sites worldwide. Knowledge of the microbial dynamics driving TNT biodegradation is limited, particularly in native aquifer sediments where it poses a threat to water resources. The purpose of this study was to quantify the effect of organic amendments on anaerobic TNT biodegradation rate and pathway in an enrichment culture obtained from historically contaminated aquifer sediment and to compare the bacterial community dynamics. TNT readily biodegraded in all microcosms, with the highest biodegradation rate obtained under the lactate amended condition followed by ethanol amended and naturally occurring organic matter (extracted from site sediment) amended conditions. Although a reductive pathway of TNT degradation was observed across all conditions, denaturing gradient gel electrophoresis (DGGE) analysis revealed distinct bacterial community compositions. In all microcosms, Gram-negative gamma- or beta-Proteobacteria and Gram-positive Negativicutes or Clostridia were observed. A Pseudomonas sp. in particular was observed to be stimulated under all conditions. According to non-metric multidimensional scaling analysis of DGGE profiles, the microcosm communities were most similar to heavily TNT-contaminated field site sediment, relative to moderately and uncontaminated sediments, suggesting that TNT contamination itself is a major driver of microbial community structure. Overall these results provide a new line of evidence of the key bacteria driving TNT degradation in aquifer sediments and their dynamics in response to organic carbon amendment, supporting this approach as a promising technology for stimulating in situ TNT bioremediation in the subsurface. C1 [Fahrenfeld, Nicole; Widdowson, Mark A.; Pruden, Amy] Virginia Tech, Blacksburg, VA 24061 USA. [Zoeckler, Jeffrey] USA, Corps Engineers, Norfolk, VA 23510 USA. RP Pruden, A (reprint author), Virginia Tech, Via Dept Civil & Environm Engn,418 Durham Hall, Blacksburg, VA 24061 USA. EM apruden@vt.edu FU Versar, Inc.; U.S. Army Corps of Engineers, Norfolk, Virginia FX Funding for this work was provided by Versar, Inc. and the U.S. Army Corps of Engineers, Norfolk, Virginia. Thanks to H. Clarkson Meredith (Versar), Jody Smiley (VT), and Rachel Kistler (VT) for technical and laboratory assistance. NR 42 TC 16 Z9 16 U1 2 U2 66 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0923-9820 J9 BIODEGRADATION JI Biodegradation PD APR PY 2013 VL 24 IS 2 BP 179 EP 190 DI 10.1007/s10532-012-9569-2 PG 12 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 098RR UT WOS:000315566900003 PM 22791276 ER PT J AU Stancoven, BW Lee, J Dixon, DR McPherson, JC Bisch, FC Wikesjo, UME Susin, C AF Stancoven, B. W. Lee, J. Dixon, D. R. McPherson, J. C., III Bisch, F. C. Wikesjoe, U. M. E. Susin, C. TI Effect of bone morphogenetic protein-2, demineralized bone matrix and systemic parathyroid hormone (1-34) on local bone formation in a rat calvaria critical-size defect model SO JOURNAL OF PERIODONTAL RESEARCH LA English DT Article DE bone formation; demineralized bone matrix; PTH; rhBMP-2; tissue engineering ID FREEZE-DRIED BONE; ALVEOLAR RIDGE AUGMENTATION; TISSUE OCCLUSION; PARTICLE-SIZE; REGENERATION; REPAIR; ALLOGRAFT; RHBMP-2; INDUCE; GROWTH AB Aim To determine the potential of recombinant human bone morphogenetic protein-2 (rhBMP-2) soak-loaded on to an absorbable collagen sponge (ACS) to induce local bone formation compared with the clinical reference demineralized bone matrix (DBM) and to investigate potential additive/synergistic effects of exogenous parathyroid hormone (PTH). Methods Critical-size (8mm), through-through calvaria osteotomy defects in 160 adult male SpragueDawley rats were randomized to receive one of eight interventions: rhBMP-2/ACS, DBM, ACS, or serve as controls (empty defects) combined or not with systemic PTH. Ten animals from each group were followed for 4 and 8wks for radiographic and histometric analysis. Multivariable analysis was used to assess the effect of experimental intervention and healing time on local bone formation. Results In the multivariable analysis, rhBMP-2/ACS exhibited significantly greater histologic bone formation than control (+/- SE: 54.76 +/- 5.85, p<0.001) and ACS (+/- SE: 9.14 +/- 3.31, p=0.007) whereas DBM showed significantly less bone formation than control (+/- SE: 32.32 +/- 8.23, p<0.001). Overall, PTH did not show a significant effect on bone formation (+/- SE: 2.72 +/- 6.91, p=0.70). No significant differences in histological defect closure were observed between 4 and 8wks for all but the control group without PTH. Conclusion rhBMP-2/ACS significantly stimulates local bone formation whereas bone formation appears significantly limited by DBM. Systemic application of PTH provided no discernible additive/synergistic effects on local bone formation. C1 [Stancoven, B. W.; Lee, J.; Wikesjoe, U. M. E.; Susin, C.] Georgia Hlth Sci Univ, LAPCR, Dept Periodont, Augusta, GA USA. [Stancoven, B. W.; Lee, J.; Wikesjoe, U. M. E.; Susin, C.] Georgia Hlth Sci Univ, LAPCR, Dept Oral Biol, Augusta, GA USA. [Stancoven, B. W.; Dixon, D. R.; Bisch, F. C.] USA, Adv Educ, Program Periodont, Ft Gordon, GA USA. [Dixon, D. R.] So Reg Dent Command, Dent Res, Ft Gordon, GA USA. [McPherson, J. C., III] USA, Dept Clin Invest, Ft Gordon, GA USA. RP Susin, C (reprint author), Georgia Hlth Sci Univ Coll Dent Med, Lab Appl Periodontal & Craniofacial Regenerat, 1120 15th St AD-1432, Augusta, GA 30912 USA. EM csusin@georgiahealth.edu RI Susin, Cristiano/B-9822-2008; Wikesjo, Ulf/A-4159-2009 OI Wikesjo, Ulf/0000-0003-1607-0583 FU US Army Dental Command; Ft Gordon DEN-TAC; 3M Non-Tenured Faculty Grant, St. Paul, MN, USA; Nobel Biocare AB, Goteborg, Sweden FX Research funding for this study was supported by the US Army Dental Command and the Ft Gordon DEN-TAC. Dr. Susin was supported in part by a 3M Non-Tenured Faculty Grant, St. Paul, MN, USA. Dr. Wikesjo was supported in part by a grant from Nobel Biocare AB, Goteborg, Sweden. NR 40 TC 11 Z9 11 U1 0 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-3484 J9 J PERIODONTAL RES JI J. Periodont. Res. PD APR PY 2013 VL 48 IS 2 BP 243 EP 251 DI 10.1111/jre.12001 PG 9 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 097JK UT WOS:000315469600014 PM 22970744 ER PT J AU Liu, DM Xiong, YH Li, Y Topping, TD Zhou, YZ Haines, C Paras, J Martin, D Kapoor, D Schoenung, JM Lavernia, EJ AF Liu, Dongming Xiong, Yuhong Li, Ying Topping, Troy D. Zhou, Yizhang Haines, Chris Paras, Joseph Martin, Darold Kapoor, Deepak Schoenung, Julie M. Lavernia, Enrique J. TI Spark Plasma Sintering of Nanostructured Aluminum: Influence of Tooling Material on Microstructure SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE LA English DT Article ID MECHANICAL-PROPERTIES; GRAIN-GROWTH; PURE ALUMINUM; POWDER; AL; PRESSURE; ALLOY; EVOLUTION; COPPER AB The influence of tooling material, i.e., graphite and WC-Co, on the microstructure of a spark plasma sintering (SPS) consolidated, nanostructured aluminum alloy is studied in this paper. The results show that tooling selection influences microstructure evolution, independent of process parameters. The influence of tooling on microstructure is rationalized on the basis of the following factors: heating rate, electrical current density, localized heating, and imposed pressure. A theoretic framework, based on the physical properties of graphite and WC-Co, is formulated to explain the observed behavior. C1 [Liu, Dongming] Shandong Univ, Dept Mat Sci & Engn, Jinan 250061, Peoples R China. [Xiong, Yuhong; Li, Ying; Topping, Troy D.; Zhou, Yizhang; Schoenung, Julie M.; Lavernia, Enrique J.] Univ Calif Davis, Dept Chem Engn & Mat Sci, Davis, CA 95616 USA. [Haines, Chris; Paras, Joseph; Martin, Darold; Kapoor, Deepak] TACOM ARDEC, USA, Picatinny Arsenal, NJ 07806 USA. RP Lavernia, EJ (reprint author), Univ Calif Davis, Dept Chem Engn & Mat Sci, Davis, CA 95616 USA. EM lavernia@ucdavis.edu RI Lavernia, Enrique/I-6472-2013; Li, Ying/G-3908-2010 OI Lavernia, Enrique/0000-0003-2124-8964; Li, Ying/0000-0003-3738-9307 FU US Army TACOM-ARDEC [W05QKN-09-C-118]; Office of Naval Research [N00014-07-1-0745]; Young Scientist Foundation of Shandong Province, China [BS2009CL043]; innovation foundation of Shandong University [2012TS032] FX This paper is based upon work supported by the US Army TACOM-ARDEC under contract No. W05QKN-09-C-118 and the Office of Naval Research with grant No. N00014-07-1-0745. Part of D. Liu's work is also supported by the Young Scientist Foundation of Shandong Province, China (No. BS2009CL043), and the innovation foundation of Shandong University (2012TS032). NR 40 TC 6 Z9 6 U1 2 U2 37 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1073-5623 J9 METALL MATER TRANS A JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci. PD APR PY 2013 VL 44A IS 4 BP 1908 EP 1916 DI 10.1007/s11661-012-1533-6 PG 9 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 096VV UT WOS:000315433700032 ER PT J AU Cervenka, MC Corines, J Boatman-Reich, DF Eloyan, A Sheng, X Franaszczuk, PJ Crone, NE AF Cervenka, Mackenzie Carpenter Corines, James Boatman-Reich, Dana Frances Eloyan, Ani Sheng, Xi Franaszczuk, Piotr Julian Crone, Nathan Earl TI Electrocorticographic functional mapping identifies human cortex critical for auditory and visual naming SO NEUROIMAGE LA English DT Article DE Language mapping; Epilepsy surgery; High gamma; Electrocorticography; Electrocortical stimulation; Surgical outcome ID EVENT-RELATED RESPONSES; CORTICAL STIMULATION; GAMMA ACTIVITY; MATCHING PURSUIT; VERB GENERATION; TEMPORAL CORTEX; WORD PRODUCTION; LANGUAGE; SPEECH; TIME AB More comprehensive, and efficient, mapping strategies are needed to avoid post-operative language impairments in patients undergoing epilepsy surgery. Conservative resection of dominant anterior frontal or temporal cortex frequently results in post-operative naming deficits despite standard pre-operative electrocortical stimulation mapping of visual object (picture) naming. Naming to auditory description may better simulate word retrieval in human conversation but is not typically tested, in part due to the time demands of electrocortical stimulation mapping. Electrocorticographic high gamma (60-150 Hz) activity, recorded simultaneously through the same electrodes used for stimulation mapping, has recently been used to map brain function more efficiently, and has at times predicted deficits not anticipated based on stimulation mapping alone. The present study investigated electrocorticographic mapping of visual object naming and auditory descriptive naming within conservative dominant temporal or frontal lobe resection boundaries in 16 patients with 933 subdural electrodes implanted for epilepsy surgery planning. A logistic regression model showed that electrodes within traditional conservative dominant frontal or temporal lobe resection boundaries were significantly more likely to record high gamma activity during auditory descriptive naming than during visual object naming. Eleven patients ultimately underwent resection and 7 demonstrated post-operative language deficits not anticipated based on electrocortical stimulation mapping alone. Four patients with post-operative deficits underwent a resection that included sites where high gamma activity was observed during naming. These findings indicate that electrocorticographic mapping of auditory descriptive naming may reduce the risk of permanent post-operative language deficits following dominant temporal or frontal resection. (C) 2012 Elsevier Inc. All rights reserved. C1 [Cervenka, Mackenzie Carpenter; Corines, James; Boatman-Reich, Dana Frances; Franaszczuk, Piotr Julian; Crone, Nathan Earl] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21287 USA. [Eloyan, Ani] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Biostat, Baltimore, MD USA. [Sheng, Xi] George Washington Univ, Dept Psychol, Washington, DC 20052 USA. [Franaszczuk, Piotr Julian] USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA. RP Cervenka, MC (reprint author), Johns Hopkins Univ, Sch Med, Dept Neurol, 600 N Wolfe St,Meyer 2-147, Baltimore, MD 21287 USA. EM mcerven1@jhmi.edu RI Franaszczuk, Piotr/B-6532-2008 OI Franaszczuk, Piotr/0000-0002-5166-4224 FU National Institutes of Neurological Disorders and Stroke [NS40596]; National Institutes of Health-National Institute of Deafness and Other Communication Disorders [DC010028, DC005645]; Epilepsy Foundation FX This work was supported by the National Institutes of Neurological Disorders and Stroke [NS40596 to N.E.C.]; National Institutes of Health-National Institute of Deafness and Other Communication Disorders [DC010028 and DC005645 to D.F.B.]; and the Epilepsy Foundation [Research and Training Fellowships for Clinicians to M.C.C.]. NR 58 TC 27 Z9 27 U1 2 U2 19 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1053-8119 J9 NEUROIMAGE JI Neuroimage PD APR 1 PY 2013 VL 69 BP 267 EP 276 DI 10.1016/j.neuroimage.2012.12.037 PG 10 WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA 085PX UT WOS:000314627800025 PM 23274183 ER PT J AU Hodges, SE McCormick, SJ AF Hodges, Steven E. McCormick, Steven J. TI Fire Extinguishing Agents for Protection of Occupied Spaces in Military Ground Vehicles SO FIRE TECHNOLOGY LA English DT Article DE Military vehicle fire protection; Fire extinguishing agents; Explosion protection of occupied areas; AFES; Clean agents; Halon 1301; FM-200BC; HFC-227BC; Novec 1230; FK-5-1-12 AB Historically the US Army used Halon 1301 (bromotrifluoromethane), a chemical with high ozone depletion potential (ODP), to protect the crews of armored vehicles from the effects of peacetime and combat fires. Since the phase-out of Halon production the US Army has directed that zero ODP materials be used wherever possible. Subsequently, major new vehicle platforms have been deployed with automatic fire extinguishing systems (AFES) that rely on HFC-227BC, a zero-ODP-agent blend of HFC-227ea (heptafluoropropane) and sodium-bicarbonate-based dry chemical. Unfortunately, hydrofluorocarbons (HFCs) generally have high global warming potential (GWP)-thousands of times that of carbon dioxide on a weight basis. Hence, as part of a larger effort to reduce its carbon footprint, US Army Program Managers have asked that fire extinguishing agents that are more environmentally friendly be evaluated as part of ongoing vehicle modernization efforts. Several agents were investigated, including FK-5-1-12, water with additives, and dry chemicals. This report describes the findings of more than 150 live-fire tests using nine agents and four extinguisher technologies. The basic conclusion is that no alternate agent can yet be considered to be a practical replacement for Halon 1301 or HFC-227BC for this application. However, a blend of Halon 1301 and dry chemical has been found to be about twice as effective as Halon 1301 alone. Thus, pending confirmation tests on vehicles, it may be feasible to use less Halon in legacy systems without compromising fire protection performance. C1 [Hodges, Steven E.] USA, TARDEC, Santa Barbara, CA 93105 USA. [McCormick, Steven J.] USA, TARDEC Ground Syst Survivabil, Warren, MI 48397 USA. RP Hodges, SE (reprint author), USA, TARDEC, 2979 La Combadura, Santa Barbara, CA 93105 USA. EM steven.e.hodges1.ctr@mail.mil FU Ground Systems Survivability (GSS) at TARDEC FX This program was funded by Ground Systems Survivability (GSS) at TARDEC and is a continuation of the work reported previously [28]. Valuable support and discussions with Ron Sheinson of the Naval Research Laboratory and Joe Senecal of United Technology Fire & Security are gratefully acknowledged. The excellent support of Aberdeen Test Center was crucial to completing these tests. NR 25 TC 3 Z9 3 U1 0 U2 75 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0015-2684 J9 FIRE TECHNOL JI Fire Technol. PD APR PY 2013 VL 49 IS 2 BP 379 EP 394 DI 10.1007/s10694-012-0271-z PG 16 WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 072CI UT WOS:000313645600008 ER PT J AU Naik, RS Liu, WY Saxena, A AF Naik, Ramachandra S. Liu, Weiyi Saxena, Ashima TI Development and validation of a simple assay for the determination of cholinesterase activity in whole blood of laboratory animals SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE cholinesterase activity; butyrylcholinesterase; acetylcholinesterase; animal whole blood; cholinesterase inhibitors; ethopropazine; (-)-huperzine A ID HUMAN SERUM BUTYRYLCHOLINESTERASE; ACETYLCHOLINESTERASE ACTIVITY; SARIN VAPOR; SOMAN; EXPOSURE; PLASMA; PRETREATMENT; PROPHYLAXIS; SPECIFICITY; INHIBITION AB Current methods for measuring acetylcholinesterase (AChE) activities in whole blood use butyrylcholinesterase (BChE)-selective inhibitors. However, the poor selectivity of these inhibitors results in the inhibition of AChE activity to some degree, leading to errors in reported values. The goal of this study was to develop and validate a simple assay for measuring AChE and BChE activities in whole blood from humans as well as experimental animals. Blood was fractionated into plasma and erythrocytes, and cholinesterase activities were titrated against ethopropazine and (-)-huperzine A to determine the lowest concentration of ethopropazine that inhibited BChE completely without affecting AChE activity and the lowest concentration of (-)-huperzine A that inhibited AChE completely without interfering with BChE activity. Results indicate that 20?mu m ethopropazine can be successfully used for the accurate measurement of AChE activity in blood from humans as well as animals. Use of (-)-huperzine A is not required for measuring BChE activity in normal or exposed blood samples. The method was validated for blood from several animal species, including mice, rats, guinea pigs, dogs, minipigs, and African green, cynomolgus and rhesus monkeys. This method is superior to all reported methods, does not require the separation of erythrocyte and plasma fractions, and is suitable for measuring cholinesterase activities in fresh or frozen blood from animals that were exposed to nerve agents or those that were administered high doses of BChE. The method is simple, direct, reproducible, and reliable and can easily be adapted for high-throughput screening of blood samples. Published 2012. This article is a US Government work and is in the public domain in the USA. C1 [Naik, Ramachandra S.; Liu, Weiyi; Saxena, Ashima] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. RP Naik, RS (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Ramachandra.Naik@us.army.mil FU Defense Threat Reduction Agency FX This work was supported by funding from the Defense Threat Reduction Agency. The authors wish to thank Ms Amy Michels for assistance in preparation of the manuscript, Russell Glorioso and Anjana Mohanty for their technical assistance, and Dr Robert diTargiani and Mr Donald M. Maxwell for conducting in vitro exposures of human blood samples to sarin and VX at the United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD, USA. NR 44 TC 6 Z9 7 U1 4 U2 60 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0260-437X J9 J APPL TOXICOL JI J. Appl. Toxicol. PD APR PY 2013 VL 33 IS 4 BP 290 EP 300 DI 10.1002/jat.2730 PG 11 WC Toxicology SC Toxicology GA 080DB UT WOS:000314220300006 PM 22407886 ER PT J AU Darrah, M Fuller, E Munasinghe, T Duling, K Gautam, M Wathen, M AF Darrah, Marjorie Fuller, Edgar Munasinghe, Thilanka Duling, Kristin Gautam, Mridul Wathen, Mitchell TI Using Genetic Algorithms for Tasking Teams of Raven UAVs SO JOURNAL OF INTELLIGENT & ROBOTIC SYSTEMS LA English DT Article DE UAVs; Genetic algorithms; Cooperative control; Tasking algorithms AB Control of multiple unmanned aerial vehicles is of importance given that so many have been deployed in the field. This work discusses how genetic algorithms (GA) have been applied to the cooperative tasking of the AeroVironment's Raven unmanned aerial vehicle (UAV) engaged in an intelligence, reconnaissance, and surveillance (ISR) mission. Mission assumptions, development of the GA, the method used to test for convergence, and the outcome of preliminary testing are all discussed. C1 [Darrah, Marjorie; Fuller, Edgar; Munasinghe, Thilanka; Duling, Kristin; Gautam, Mridul] W Virginia Univ, Morgantown, WV 26506 USA. [Wathen, Mitchell] USA, Res Lab, Adelphi, MD USA. RP Darrah, M (reprint author), W Virginia Univ, Morgantown, WV 26506 USA. EM mdarrah@math.wvu.edu OI Fuller, Edgar/0000-0003-4130-090X FU U.S Army Research Laboratory [W911NF-10-2-0110] FX This work has been supported by U.S Army Research Laboratory under Cooperative Agreement no. W911NF-10-2-0110. NR 24 TC 5 Z9 6 U1 3 U2 39 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0921-0296 EI 1573-0409 J9 J INTELL ROBOT SYST JI J. Intell. Robot. Syst. PD APR PY 2013 VL 70 IS 1-4 SI SI BP 361 EP 371 DI 10.1007/s10846-012-9696-3 PG 11 WC Computer Science, Artificial Intelligence; Robotics SC Computer Science; Robotics GA 058OE UT WOS:000312642600025 ER PT J AU Cao, XY Chappell, MA Schimmelmann, A Mastalerz, M Li, Y Hu, WG Mao, JD AF Cao, Xiaoyan Chappell, Mark A. Schimmelmann, Arndt Mastalerz, Maria Li, Yuan Hu, Weiguo Mao, Jingdong TI Chemical structure changes in kerogen from bituminous coal in response to dike intrusions as investigated by advanced solid-state C-13 NMR spectroscopy SO INTERNATIONAL JOURNAL OF COAL GEOLOGY LA English DT Article DE Kerogen; Bituminous coal; Dike intrusion; NMR ID NUCLEAR-MAGNETIC-RESONANCE; IGNEOUS INTRUSION; VITRINITE REFLECTANCE; ORGANIC-MATTER; ILLINOIS BASIN; PITKIN COUNTY; WHOLE-COAL; CPMAS NMR; GEOCHEMISTRY; METAMORPHISM AB Coal maturation due to igneous intrusions offers the ideal opportunity to study the chemical-structural evolution of rapidly heated coal. Variations in the chemical structures of kerogens from high volatile bituminous coal near two igneous dike intrusions in the Illinois Basin were characterized in detail by advanced solid-state C-13 nuclear magnetic resonance (NMR) spectroscopy. With decreasing distance to dike contacts and increasing thermal maturity (vitrinite reflectance R-o from 0.62% to 5.03%), the new insights into the chemical structural changes in coal kerogens include (i) the C(CH2)C groups removed faster than CCH3 groups, suggesting that the major cleavage of aliphatics should not occur at aryl rings, (ii) a progressive decrease of the relative abundance of protonated aromatic carbons, possibly due to replacement of aromatic hydrogens by aryl groups via cross-linking, and (iii) an increase in the aromatic cluster size, in addition to the well established changes of the elimination of aliphatics and aromatic C-O groups and an increase in aromaticity. For the first time the growth of aromatic cluster sizes with increasing maturity was quantitatively estimated. Another novel finding is that coal kerogen (kerogen #22) directly at the contact with the large dike retained considerable aliphatic components with olefinic and COO groups. These aliphatic components could have been entrapped and failed to diffuse out rapidly enough because intense and very fast heating rendered this kerogen partially fluidized. Our advanced solid-state NMR techniques provided deep insights into the structural changes in kerogen from bituminous coal in response to dike intrusions which cannot be achievable using routine C-13 cross polarization/magic angle spinning technique. (C) 2012 Elsevier B.V. All rights reserved. C1 [Cao, Xiaoyan; Li, Yuan; Mao, Jingdong] Old Dominion Univ, Dept Chem & Biochem, Norfolk, VA 23529 USA. [Chappell, Mark A.] USA, Corps Engineers, Environm Lab, Vicksburg, MS 39180 USA. [Schimmelmann, Arndt] Indiana Univ, Dept Geol Sci, Bloomington, IN 47405 USA. [Mastalerz, Maria] Indiana Univ, Indiana Geol Survey, Bloomington, IN 47405 USA. [Hu, Weiguo] Univ Massachusetts, Dept Polymer Sci & Engn, Amherst, MA 01003 USA. RP Mao, JD (reprint author), Old Dominion Univ, Dept Chem & Biochem, 4541 Hampton Blvd, Norfolk, VA 23529 USA. EM jmao@odu.edu RI Cao, Xiaoyan/E-3492-2012 OI Cao, Xiaoyan/0000-0001-7571-6482 FU National Science Foundation [EAR-0843996, CBET-0853950]; Petroleum Research Fund [46373-G2, 44815-AC2]; U.S. Department of Energy, Basic Energy Research [DEFG02-00ER15032] FX This research was supported by National Science Foundation grants EAR-0843996 and CBET-0853950, and by the Donors of the Petroleum Research Fund, administered by the American Chemical Society, grant 46373-G2. Arndt Schimmelmann and Maria Mastalerz acknowledge support from the U.S. Department of Energy, Basic Energy Research Grant DEFG02-00ER15032, and from the Donors of the Petroleum Research Fund, administered by the American Chemical Society, grant 44815-AC2. NR 53 TC 16 Z9 16 U1 4 U2 34 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-5162 J9 INT J COAL GEOL JI Int. J. Coal Geol. PD MAR 30 PY 2013 VL 108 SI SI BP 53 EP 64 DI 10.1016/j.coal.2012.05.002 PG 12 WC Energy & Fuels; Geosciences, Multidisciplinary SC Energy & Fuels; Geology GA 110GD UT WOS:000316429700008 ER PT J AU Reid, GA Chilukuri, N Darvesh, S AF Reid, G. A. Chilukuri, N. Darvesh, S. TI BUTYRYLCHOLINESTERASE AND THE CHOLINERGIC SYSTEM SO NEUROSCIENCE LA English DT Article DE cholinesterases; acetylcholinesterase; pseudocholinesterase; choline acetyltransferase; 129S1/SvImJ mice; acetylcholine ID SPINAL-CORD; HYDROLYZE ACETYLCHOLINE; HUMAN THALAMUS; BRAIN-STEM; RAT-BRAIN; ACETYLTRANSFERASE; NEURONS; MOUSE; LOCALIZATION; MICE AB The cholinergic system plays important roles in neurotransmission in both the peripheral and central nervous systems. The cholinergic neurotransmitter acetylcholine is synthesized by choline acetyltransferase (ChAT) and its action terminated by acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The predominance of AChE has focused much attention on understanding the relationship of this enzyme to ChAT-positive cholinergic neurons. However, there is ample evidence that BuChE also plays an important role in cholinergic regulation. To elucidate the relationship of BuChE to neural elements that are producing acetylcholine, the distribution of this enzyme was compared to that of ChAT in the mouse CNS. Brain tissues from 129S1/SvImJ mice were stained for BuChE and ChAT using histochemical, immunohistochemical and immunofluorescent techniques. Both BuChE and ChAT were found in neural elements throughout the CNS. BuChE staining with histochemistry and immunohistochemistry produced the same distribution of labeling throughout the brain and spinal cord. Immunofluorescent double labeling demonstrated that many nuclei in the medulla oblongata, as well as regions of the spinal cord, had neurons that contained both BuChE and ChAT. BuChE-positive neurons without ChAT were found in close proximity with ChAT-positive neuropil in areas such as the thalamus and amygdala. BuChE-positive neuropil was also found closely associated with ChAT-positive neurons, particularly in tegmental nuclei of the pons. These observations provide further neuroanatomical evidence of a role for BuChE in the regulation of acetylcholine levels in the CNS. (C) 2013 IBRO. Published by Elsevier Ltd. All rights reserved. C1 [Reid, G. A.; Darvesh, S.] Dalhousie Univ, Dept Med Neurosci, Halifax, NS B3H 2E1, Canada. [Chilukuri, N.] USA, Div Res, Physiol & Immunol Branch, Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Darvesh, S.] Dalhousie Univ, Dept Med Neurol & Geriatr Med, Halifax, NS B3H 2E1, Canada. RP Darvesh, S (reprint author), Dalhousie Univ, Dept Med Neurosci, Room 1308,Camp Hill Vet Mem,5955 Vet Mem Lane, Halifax, NS B3H 2E1, Canada. EM sultan.darvesh@dal.ca FU Canadian Institutes of Health Research; Capital District Health Authority Research Fund; Nova Scotia Health Research Foundation; Faculty of Medicine (Clinician-Scientist Program); Dalhousie University Department of Medicine (University Internal Medicine Research Fund); Dalhousie Medical Research Foundation; Defense Threat Reduction Agency (DTRA), Joint Science and Technology Office, Medical ST Division FX This work was supported in part by Canadian Institutes of Health Research, Capital District Health Authority Research Fund, Nova Scotia Health Research Foundation, Faculty of Medicine (Clinician-Scientist Program), Dalhousie University Department of Medicine (University Internal Medicine Research Fund) and Dalhousie Medical Research Foundation (S.D.) and Defense Threat Reduction Agency (DTRA), Joint Science and Technology Office, Medical S&T Division (N.C.). We would like to thank Professor Earl Martin for critically reviewing this manuscript. NR 48 TC 9 Z9 10 U1 0 U2 19 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0306-4522 J9 NEUROSCIENCE JI Neuroscience PD MAR 27 PY 2013 VL 234 BP 53 EP 68 DI 10.1016/j.neuroscience.2012.12.054 PG 16 WC Neurosciences SC Neurosciences & Neurology GA 111OG UT WOS:000316530000006 PM 23305761 ER PT J AU Bethell, D Saunders, D Jongkaewwattana, A Kramyu, J Thitithayanont, A Wiboon-ut, S Yongvanitchit, K Limsalakpetch, A Kum-Arb, U Uthaimongkol, N Garcia, JM Timmermans, AE Peiris, M Thomas, S Engering, A Jarman, RG Mongkolsirichaikul, D Mason, C Khemnu, N Tyner, SD Fukuda, MM Walsh, DS Pichyangkul, S AF Bethell, Delia Saunders, David Jongkaewwattana, Anan Kramyu, Jarin Thitithayanont, Arunee Wiboon-ut, Suwimon Yongvanitchit, Kosol Limsalakpetch, Amporn Kum-Arb, Utaiwan Uthaimongkol, Nichapat Garcia, Jean Michel Timmermans, Ans E. Peiris, Malik Thomas, Stephen Engering, Anneke Jarman, Richard G. Mongkolsirichaikul, Duangrat Mason, Carl Khemnu, Nuanpan Tyner, Stuart D. Fukuda, Mark M. Walsh, Douglas S. Pichyangkul, Sathit TI Evaluation of In Vitro Cross-Reactivity to Avian H5N1 and Pandemic H1N1 2009 Influenza Following Prime Boost Regimens of Seasonal Influenza Vaccination in Healthy Human Subjects: A Randomised Trial SO PLOS ONE LA English DT Article ID T-CELLS; NEURAMINIDASE ANTIBODY; A VIRUS; MF59-ADJUVANTED INFLUENZA; VACCINES; LIVE; PROTECTION; RESPONSES; IMMUNITY; MICE AB Introduction: Recent studies have demonstrated that inactivated seasonal influenza vaccines (IIV) may elicit production of heterosubtypic antibodies, which can neutralize avian H5N1 virus in a small proportion of subjects. We hypothesized that prime boost regimens of live and inactivated trivalent seasonal influenza vaccines (LAIV and IIV) would enhance production of heterosubtypic immunity and provide evidence of cross-protection against other influenza viruses. Methods: In an open-label study, 26 adult volunteers were randomized to receive one of four vaccine regimens containing two doses of 2009-10 seasonal influenza vaccines administered 8 (61) weeks apart: 2 doses of LAIV; 2 doses of IIV; LAIV then IIV; IIV then LAIV. Humoral immunity assays for avian H5N1, 2009 pandemic H1N1 (pH1N1), and seasonal vaccine strains were performed on blood collected pre-vaccine and 2 and 4 weeks later. The percentage of cytokine-producing T-cells was compared with baseline 14 days after each dose. Results: Subjects receiving IIV had prompt serological responses to vaccine strains. Two subjects receiving heterologous prime boost regimens had enhanced haemagglutination inhibition (HI) and neutralization (NT) titres against pH1N1, and one subject against avian H5N1; all three had pre-existing cross-reactive antibodies detected at baseline. Significantly elevated titres to H5N1 and pH1N1 by neuraminidase inhibition (NI) assay were observed following LAIV-IIV administration. Both vaccines elicited cross-reactive CD4+ T-cell responses to nucleoprotein of avian H5N1 and pH1N1. All regimens were safe and well tolerated. Conclusion: Neither homologous nor heterologous prime boost immunization enhanced serum HI and NT titres to 2009 pH1N1 or avian H5N1 compared to single dose vaccine. However heterologous prime-boost vaccination did lead to in vitro evidence of cross-reactivity by NI; the significance of this finding is unclear. These data support the strategy of administering single dose trivalent seasonal influenza vaccine at the outset of an influenza pandemic while a specific vaccine is being developed. C1 [Bethell, Delia; Saunders, David; Yongvanitchit, Kosol; Limsalakpetch, Amporn; Kum-Arb, Utaiwan; Uthaimongkol, Nichapat; Timmermans, Ans E.; Engering, Anneke; Tyner, Stuart D.; Fukuda, Mark M.; Walsh, Douglas S.; Pichyangkul, Sathit] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. [Jongkaewwattana, Anan; Kramyu, Jarin] Natl Ctr Genet Engn & Biotechnol, Virol & Cell Technol Lab, Bangkok, Thailand. [Thitithayanont, Arunee; Wiboon-ut, Suwimon] Mahidol Univ, Fac Sci, Bangkok 10400, Thailand. [Garcia, Jean Michel; Peiris, Malik] Univ Hong Kong Pasteur Res Ctr, Hong Kong Special Adm Reg, Hong Kong, Hong Kong, Peoples R China. [Thomas, Stephen; Jarman, Richard G.; Mongkolsirichaikul, Duangrat] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Mason, Carl; Khemnu, Nuanpan] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand. RP Bethell, D (reprint author), Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. EM delia.bethell@afrims.org RI Garcia, Jean-Michel/J-7166-2013 OI Garcia, Jean-Michel/0000-0002-6005-9982 FU MedImmune FX This study was funded by a MedImmune Investigator-Initiated Research Program grant from MedImmune. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 35 TC 7 Z9 7 U1 0 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 26 PY 2013 VL 8 IS 3 AR e59674 DI 10.1371/journal.pone.0059674 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 123VE UT WOS:000317418500072 PM 23555741 ER PT J AU Weber, NS Fisher, JA Cowan, DN Postolache, TT Larsen, RA Niebuhr, DW AF Weber, Natalya S. Fisher, Jared A. Cowan, David N. Postolache, Teodor T. Larsen, Rakel A. Niebuhr, David W. TI Descriptive Epidemiology and Underlying Psychiatric Disorders among Hospitalizations with Self-Directed Violence SO PLOS ONE LA English DT Article ID ATTEMPTED-SUICIDE; UNITED-STATES; HARM; LETHALITY; INJURY; ADULTS; INTENT; RATES; RISK AB Background: Suicide claims over one million lives worldwide each year. In the United States, 1 per 10,000 persons dies from suicide every year, and these rates have remained relatively constant over the last 20 years. There are nearly 25 suicide attempts for each suicide, and previous self-directed violence is a strong predictor of death from suicide. While many studies have focused on suicides, the epidemiology of non-fatal self-directed violence is not well-defined. Objective: We used a nationally representative survey to examine demographics and underlying psychiatric disorders in United States (US) hospitalizations with non-fatal self-directed violence (SDV). Method: International Classification of Disease, 9th Revision (ICD-9) discharge diagnosis data from the National Hospital Discharge Survey (NHDS) were examined from 1997 to 2006 using frequency measures and adjusted logistic regression. Results: The rate of discharges with SDV remained relatively stable over the study time period with 4.5 to 5.7 hospitalizations per 10,000 persons per year. Excess SDV was documented for females, adolescents, whites, and those from the Midwest or West. While females had a higher likelihood of self-poisoning, both genders had comparable proportions of hospitalizations with SDV resulting in injury. Over 86% of the records listing SDV also included psychiatric disorders, with the most frequent being affective (57.8%) and substance abuse (37.1%) disorders. The association between psychiatric disorders and self-injury was strongest for personality disorders for both males (OR = 2.1; 95% CI = 1.3-3.4) and females (OR = 3.8; 95% CI = 2.7-5.3). Conclusion: The NHDS provides new insights into the demographics and psychiatric morbidity of those hospitalized with SDV. Classification of SDV as self-injury or self-poisoning provides an additional parameter useful to epidemiologic studies. C1 [Weber, Natalya S.; Fisher, Jared A.; Cowan, David N.; Larsen, Rakel A.; Niebuhr, David W.] Walter Reed Army Inst Res, Prevent Med Program, Silver Spring, MD USA. [Fisher, Jared A.; Cowan, David N.; Larsen, Rakel A.] Allied Technol Grp Inc, Rockville, MD USA. [Postolache, Teodor T.] Univ Maryland, Sch Med, Dept Psychiat, Mood & Anxiety Program, Baltimore, MD 21201 USA. [Niebuhr, David W.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. RP Weber, NS (reprint author), Walter Reed Army Inst Res, Prevent Med Program, Silver Spring, MD USA. EM Natalya.Weber@us.army.mil FU Stanley Medical Research Institute, Bethesda, MD, (CRADA) [DAMD17-04-0041]; Department of the Army; Walter Reed Army Institute of Research (WRAIR) FX The effort is funded by the Stanley Medical Research Institute, Bethesda, MD, (CRADA# DAMD17-04-0041, http://www.stanleyresearch.org/dnn/ResearchGrants/Overview/tabid/156/Def ault.aspx) and the Department of the Army. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.; ATG has had a service support contract with the Walter Reed Army Institute of Research (WRAIR) for over 15 years. ATG personnel include epidemiologists and statisticians who support and collaborate with the WRAIR researchers. ATG staff are all at the master's or doctoral level of training, and they assist in the design, analysis, interpretation and presentation of studies, and in writing and publishing of manuscripts for peer-reviewed journals. There is no financial or other conflict of interest between ATG staff and any of the research with which they participate. ATG and its staff members are contractors with no vested interests in the results, conclusions, and recommendations resulting from any research and have no interests related to employment, consultancy, patents, products in development or marketed products, or any other aspect of this research. Even though Natalya S. Weber, M. D., M. P. H., is a PLOS One Editorial board member, this does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. NR 41 TC 5 Z9 5 U1 0 U2 9 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 26 PY 2013 VL 8 IS 3 AR e59818 DI 10.1371/journal.pone.0059818 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 123VE UT WOS:000317418500094 PM 23555791 ER PT J AU Naik, RS Pattabiraman, N Patel, KA Doctor, BP Saxena, A AF Naik, Ramachandra S. Pattabiraman, Nagarajan Patel, Kunjan A. Doctor, Bhupendra P. Saxena, Ashima TI Amino acid residues at the N- and C-termini are essential for the folding of active human butyrylcholinesterase polypeptide SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT International Meeting on Cholinesterases CY JUN 04-09, 2012 CL Kazan, RUSSIA DE Human butyrylcholinesterase; Nerve agent; Organophosphorus compounds; Polypeptide; Bioscavenger ID ACETYLCHOLINESTERASE; CHOLINESTERASES; PROTECTION; INHIBITORS; TOXICITY; PROTEINS; SOMAN AB Human serum butyrylcholinesterase (HuBChE) is currently the most suitable bioscavenger for the prophylaxis of highly toxic organophosphate (OP) nerve agents. A dose of 200 mg of HuBChE is envisioned as a prophylactic treatment that can protect humans from an exposure of up to 2 x LD50 of soman. The limited availability and administration of multiple doses of this stoichiometric bioscavenger make this pretreatment difficult. Thus, the goal of this study was to produce a smaller enzymatically active HuBChE polypeptide (HBP) that could bind to nerve agents with high affinity thereby reducing the dose of enzyme. Studies have indicated that the three-dimensional structure and the domains of HuBChE (acyl pocket, lip of the active center gorge, and the anionic substrate-binding domain) that are critical for the binding of substrate are also essential for the selectivity and binding of inhibitors including OPs. Therefore, we designed three HBPs by deleting some N- and C-terminal residues of HuBChE by maintaining the folds of the active site core that includes the three active site residues (S198, E325, and H438). HBP-4 that lacks 45 residues from C-terminus but known to have BChE activity was used as a control. The cDNAs for the HBPs containing signal sequences were synthesized, cloned into different mammalian expression vectors, and recombinant polypeptides were transiently expressed in different cell lines. No BChE activity was detected in the culture media of cells transfected with any of the newly designed HBPs, and the inactive polypeptides remained inside the cells. Only enzymatically active HBP-4 was secreted into the culture medium. These results suggest that residues at the N- and C-termini are required for the folding and/or maintenance of HBP into an active stable, conformation. Published by Elsevier Ireland Ltd. C1 [Naik, Ramachandra S.; Pattabiraman, Nagarajan; Patel, Kunjan A.; Saxena, Ashima] Walter Reed Army Inst Res, Bacterial Dis Branch, Silver Spring, MD 20910 USA. [Doctor, Bhupendra P.] Walter Reed Army Inst Res, Closed Head Injury Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Saxena, A (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM ashima.saxena@us.army.mil FU Defense Threat Reduction Agency FX This work was supported by the Defense Threat Reduction Agency which played no role in the design, conduct, interpretation, or report of the study. The opinions or assertions contained herein are the private views of the authors, and are not to be construed as official, or as reflecting true views of the Department of the Army or the Department of Defense. NR 18 TC 0 Z9 0 U1 0 U2 21 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 EI 1872-7786 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD MAR 25 PY 2013 VL 203 IS 1 SI SI BP 24 EP 29 DI 10.1016/j.cbi.2012.09.018 PG 6 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 134HU UT WOS:000318201800006 PM 23044488 ER PT J AU Maxwell, DM Brecht, KM Sweeney, RE AF Maxwell, Donald M. Brecht, Karen M. Sweeney, Richard E. TI A common mechanism for resistance to oxime reactivation of acetylcholinesterase inhibited by organophosphorus compounds SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT International Meeting on Cholinesterases CY JUN 04-09, 2012 CL Kazan, RUSSIA DE Acetylcholinesterase; Oxime; Reactivation; Organophosphorus; Structure-activity ID CRYSTAL-STRUCTURES; KINETIC-ANALYSIS; CHOLINESTERASES AB Administration of oxime therapy is currently the standard approach used to reverse the acute toxicity of organophosphorus (OP) compounds, which is usually attributed to OP inhibition of acetylcholinesterase (AChE). Rate constants for reactivation of OP-inhibited AChE by even the best oximes, such as HI-6 and obidoxime, can vary >100-fold between OP-AChE conjugates that are easily reactivated and those that are difficult to reactivate. To gain a better understanding of this oxime specificity problem for future design of improved reactivators, we conducted a QSAR analysis for oxime reactivation of AChE inhibited by OP agents and their analogues. Our objective was to identify common mechanism(s) among OP-AChE conjugates of phosphates, phosphonates and phosphoramidates that result in resistance to oxime reactivation. Our evaluation of oxime reactivation of AChE inhibited by a satin analogue, O-methyl isopropylphosphonofluoridate, or a cyclosarin analogue, O-methyl cyclohexylphosphonofluoridate, indicated that AChE inhibited by these analogues was at least 70-fold more difficult to reactivate than AChE inhibited by sarin or cyclosarin. In addition, AChE inhibited by an analogue of tabun (i.e., O-ethyl isopropylphosphonofluoridate) was nearly as resistant to reactivation as tabun-inhibited AChE. QSAR analysis of oxime reactivation of AChE inhibited by these OP compounds and others suggested that the presence of both a large substituent (i.e., the size of dimethylamine) and an alkoxy substituent in the structure of OP compounds is the common feature that results in resistance to oxime reactivation of OP-AChE conjugates whether the OP is a phosphate, phosphonate or phosphoramidate. Published by Elsevier Ireland Ltd. C1 [Maxwell, Donald M.; Brecht, Karen M.; Sweeney, Richard E.] USA, Med Res Inst Chem Def, Pharmacol Branch, Aberdeen Proving Ground, MD 21010 USA. RP Maxwell, DM (reprint author), USA, Med Res Inst Chem Def, Pharmacol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM donald.maxwell@us.army.mil FU Defense Threat Reduction Agency - Joint Science and Technology Office, Medical S T Division FX This research was supported by the Defense Threat Reduction Agency - Joint Science and Technology Office, Medical S & T Division. The views expressed in this paper are those of the authors and do not reflect the official policy of the Department of Army, Department of Defense or the US Government. NR 20 TC 7 Z9 7 U1 1 U2 41 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 EI 1872-7786 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD MAR 25 PY 2013 VL 203 IS 1 SI SI BP 72 EP 76 DI 10.1016/j.cbi.2012.08.024 PG 5 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 134HU UT WOS:000318201800016 PM 22982773 ER PT J AU Wang, Y Wei, YL Oguntayo, S Doctor, BP Nambiar, MP AF Wang, Ying Wei, Yanling Oguntayo, Samuel Doctor, Bhupendra P. Nambiar, Madhusoodana P. TI A combination of [ plus ] and [-]-Huperzine A improves protection against soman toxicity compared to [ plus ]-Huperzine A in guinea pigs SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT International Meeting on Cholinesterases CY JUN 04-09, 2012 CL Kazan, RUSSIA DE Neuroprotection; Prophylaxis; Nerve agents; [ plus ]-Huperzine A; [-]-Huperzine A; Seizure; Acetylcholinesterase ID BETA-AMYLOID PEPTIDE; NERVE AGENT TOXICITY; RAT PC12 CELLS; HUPERZINE-A; INDUCED SEIZURES; HUMAN BUTYRYLCHOLINESTERASE; OXIDATIVE STRESS; GROWTH-FACTOR; IN-VITRO; ACETYLCHOLINESTERASE AB The neuropathologic mechanisms after exposure to lethal doses of nerve agent are complex and involve multiple biochemical pathways. Effective treatment requires drugs that can simultaneously protect by reversible binding to the acetylcholinesterase (AChE) and blocking cascades of seizure related brain damage, inflammation, neuronal degeneration as well as promoting induction of neuroregeneration. [-]-Huperzine A ([-]-Hup A), is a naturally occurring potent reversible AChE inhibitor that penetrates the blood brain barrier. It also has several neuroprotective effects including modification of beta-amyloid peptide, reduction of oxidative stress, anti-inflammatory, anti-apoptotic and induction and regulation of nerve growth factor. Toxicities at higher doses restrict the neuroporotective ability of [-]-Hup A for treatment. The synthetic stereoisomer, [+]-Hup A, is less toxic due to poor AChE inhibition and is suitable for both pre-/post-exposure treatments of nerve agent toxicity. [+]-Hup A block the N-methyl-D-aspartate (NMDA)-induced seizure in rats, reduce excitatory amino acid induced neurotoxicity and also prevent soman induced toxicity with minimum performance decrement. Unique combinations of two stereoisomers of Hup A may provide an excellent pre/post-treatment drug for the nerve agent induced seizure/status epilepticus. We investigated a combination of [+]-Hup A with a small dose of [+]-Hup A ([+] and [-]-Hup A) against soman toxicity. Our data showed that pretreatment with a combination [+] and [-]-Hup A significantly increased the survival rate and reduced behavioral abnormalities after exposure to 1.2 x LD50 soman compared to [+]-Hup A in guinea pigs. In addition, [+] and [-]-Hup A pretreatment inhibited the development of high power of EEG better than [+]-Hup A pretreatment alone. These data suggest that a combination of [+] and [-]-Hup A offers better protection than [+]-Hup A and serves as a potent medical countermeasure against lethal dose nerve agent toxicity in guinea pigs. (C) 2012 Published by Elsevier Ireland Ltd. C1 [Wang, Ying; Wei, Yanling; Oguntayo, Samuel; Doctor, Bhupendra P.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Blast Induced Neurotrauma Branch, Silver Spring, MD 20910 USA. RP Nambiar, MP (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Blast Induced Neurotrauma Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM ying.wangv@us.army.mil; Madhusoodana.nambiar@us.army.mil FU Defense Threat Reduction Agency (DTRA) [1.E0003_08_WR_C] FX This work was supported by funding from Defense Threat Reduction Agency (DTRA) Grant #1.E0003_08_WR_C. The technical assistance from the Collaborative Research Facility, USAMRICD is greatly acknowledged. NR 47 TC 8 Z9 8 U1 0 U2 5 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 EI 1872-7786 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD MAR 25 PY 2013 VL 203 IS 1 SI SI BP 120 EP 124 DI 10.1016/j.cbi.2012.10.016 PG 5 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 134HU UT WOS:000318201800025 PM 23123250 ER PT J AU Bhonsle, JB Causey, R Oyler, BL Bartolucci, C Lamba, D Pesaresi, A Bhamare, NK Soojhawon, I Garcia, GE AF Bhonsle, Jayendra B. Causey, Robert Oyler, Benjamin L. Bartolucci, Cecilia Lamba, Doriano Pesaresi, Alessandro Bhamare, Nanaji K. Soojhawon, Iswarduth Garcia, Gregory E. TI Evaluation and computational characterization of the facilitated transport of Glc carbon C-1 oxime reactivators across a blood brain barrier model SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT International Meeting on Cholinesterases CY JUN 04-09, 2012 CL Kazan, RUSSIA DE Facilitated transport; Sugar-oximes; SOx; Blood brain barrier; Reactivation; Acetylcholinesterase ID GLUT1 GLUCOSE-TRANSPORTER; NERVE AGENTS; ACETYLCHOLINESTERASE; ANTIDOTES; DERIVATIVES; MECHANISM; CONTAINS; EFFICACY; DOCKING; HI-6 AB We are evaluating a facilitative transport strategy to move oximes across the blood brain barrier (BBB) to reactivate inhibited brain acetylcholinesterase (AChE). We selected glucose (Glc) transporters (GLUT) for this purpose as these transporters are highly represented in the BBB. Glc conjugates have successfully moved drugs across the BBB and previous work has shown that Glc-oximes (sugar-oximes, SOxs) can reduce the organophosphonate induced hypothermia response. We previously evaluated the reactivation potential of Glc carbon C-1 SOxs. Here we report the reactivation parameters for VX- and GB-inhibited human (Hu) AChE of the best SOx (13c) and our findings that the kinetics are similar to those of the parent oxime. Although crystals of Torpedo californica AChE were produced, neither soaked or co-crystallized experiments were successful at concentrations below 20 mM 13c, and higher concentrations cracked the crystals. 13c was non-toxic to neuroblastoma and kidney cell lines at 12-18 mM, allowing high concentrations to be used in a BBB kidney cell model. The transfer of 13c from the donor side was asymmetric with the greatest loss of 13c from the apical- or luminal-treated side. There was no apparent transfer from the basolateral side. The 13c P-app results indicate a 'low' transport efficiency: however, mass accounting revealed only a 20% recovery from the apical dose in which high concentrations were found in the cell lysate fraction. Molecular modeling of 13c through the GLUT-1 channel demonstrated that transport of 13c was more restricted than Glc. Selected sites were compared and the 13c binding energies were greater than two times those of Glc. Published by Elsevier Ireland Ltd. C1 [Bhonsle, Jayendra B.] Astha Drug Discovery & Res, Rockville, MD 20852 USA. [Causey, Robert; Bhamare, Nanaji K.; Garcia, Gregory E.] USA, Med Res Inst Chem Def, Div Res, Aberdeen Proving Ground, MD 21010 USA. [Oyler, Benjamin L.] USA, Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA. [Bartolucci, Cecilia] CNR, Ist Cristallografia, I-00015 Monterotondo, Roma, Italy. [Lamba, Doriano; Pesaresi, Alessandro] CNR, Ist Cristallografia, I-34149 Trieste, Italy. [Soojhawon, Iswarduth] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. RP Garcia, GE (reprint author), USA, Med Res Inst Chem Def, Div Res, 3100 Ricketts,Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM Gregory.E.Garcia@us.army.mil RI Lamba, Doriano/B-2961-2011; OI Lamba, Doriano/0000-0001-6859-7868; Oyler, Benjamin/0000-0003-3436-9175 FU Defense Threat Reduction Agency [1.E005.08.WR] FX Excellent technical assistance was provided by Ms. Janine Ladzinski for cell culture toxicological testing. This work was supported by Defense Threat Reduction Agency (Grant number 1.E005.08.WR). The views expressed herein are those of the author(s) and do not reflect the official policy of the Department of Army, Department of Defense, or the U.S. Government. NR 27 TC 1 Z9 2 U1 1 U2 11 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 EI 1872-7786 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD MAR 25 PY 2013 VL 203 IS 1 SI SI BP 129 EP 134 DI 10.1016/j.cbi.2012.09.012 PG 6 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 134HU UT WOS:000318201800027 PM 23073172 ER PT J AU Sun, W Luo, C Tipparaju, P Doctor, BP Saxena, A AF Sun, Wei Luo, Chunyuan Tipparaju, Prasanthi Doctor, Bhupendra P. Saxena, Ashima TI Effect of polyethylene glycol conjugation on the circulatory stability of plasma-derived human butyrylcholinesterase in mice SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT International Meeting on Cholinesterases CY JUN 04-09, 2012 CL Kazan, RUSSIA DE Butyrylcholinesterase; Bioscavenger; Polyethylene glycol; Organophosphorus compounds; Circulatory stability; Mice ID HUMAN SERUM BUTYRYLCHOLINESTERASE; RECOMBINANT HUMAN BUTYRYLCHOLINESTERASE; NERVE AGENT TOXICITY; IN-VIVO STABILITY; HALF-LIFE; COVALENT ATTACHMENT; COCAINE TOXICITY; SARIN VAPOR; GUINEA-PIGS; CHOLINESTERASE AB Exogenously administered human serum butyrylcholinesterase (Hu BChE) was demonstrated to function as a bioscavenger of highly toxic organophosphorus (OP) compounds in several animal species. Since the enzyme is isolated from human serum, it is currently the most suitable pretreatment for human use. A dose of 200-300 mg/70 kg human adult is projected to provide protection from 2 x LD50 of soman. Due to the limited supply of Hu BChE, strategies aimed at reducing the dose of enzyme are being explored. In this study, we investigated the effect of modification with polyethylene glycol (PEG) on the in vivo stability of Hu BChE. Mice were given two injections of either Hu BChE or Hu BChE modified with PEG-5K or PEG-20K, six weeks apart. Pharmacokinetic parameters, such as mean residence time (MRT), maximal concentration (C-max), elimination half-life (T-1/2), and area under the plasma concentration time curve extrapolated to infinity (AUC), were determined. For the first injection, values for MRT, T-1/2, C-max, and AUC for PEG-5K-Hu BChE and PEG-20K-Hu BChE were similar to those for Hu BChE. These values for the second injection of Hu BChE as well as PEG-Hu BChEs were lower as compared to those for the first injections, likely due to antibody-mediated clearance. Published by Elsevier Ireland Ltd. C1 [Sun, Wei; Luo, Chunyuan; Tipparaju, Prasanthi; Doctor, Bhupendra P.; Saxena, Ashima] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. RP Saxena, A (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Ashima.saxena@us.army.mil FU United States Army Medical Research and Materiel Command FX The authors wish to thank Dr. Yvonne Rosenberg and Dr. Xiaoming Jiang (Plantvax Inc., Rockville, MD) for help with the calculations of pharmacokinetic parameters. This work was supported by the United States Army Medical Research and Materiel Command. NR 33 TC 6 Z9 6 U1 1 U2 12 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 EI 1872-7786 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD MAR 25 PY 2013 VL 203 IS 1 SI SI BP 172 EP 176 DI 10.1016/j.cbi.2012.11.021 PG 5 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 134HU UT WOS:000318201800035 PM 23220586 ER PT J AU Hodgins, SM Kasten, SA Harrison, J Otto, TC Oliver, ZP Rezk, P Reeves, TE Chilukuri, N Cerasoli, DM AF Hodgins, Sean M. Kasten, Shane A. Harrison, Joshua Otto, Tamara C. Oliver, Zeke P. Rezk, Peter Reeves, Tony E. Chilukuri, Nageswararao Cerasoli, Douglas M. TI Assessing protection against OP pesticides and nerve agents provided by wild-type HuPON1 purified from Trichoplusia ni larvae or induced via adenoviral infection SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT International Meeting on Cholinesterases CY JUN 04-09, 2012 CL Kazan, RUSSIA DE Organophosphorus; Nerve agent; Paraoxonase 1; Catalytic bioscavenger; In vivo efficacy ID HUMAN SERUM PARAOXONASE; HYDROLYSIS; POLYMORPHISM; HYDROLASES; DIAZOXON; ESTERS; SOMAN; PON1 AB Human paraoxonase-1 (HuPON1) has been proposed as a catalytic bioscavenger of organophosphorus (OP) pesticides and nerve agents. We assessed the potential of this enzyme to protect against OP poisoning using two different paradigms. First, recombinant HuPON1 purified from cabbage loopers (iPON1; Trichoplusia ni) was administered to guinea pigs, followed by exposure to at least 2 times the median lethal dose (LD50) of the OP nerve agents tabun (GA), satin (GB), soman (GD), and cyclosarin (GF), or chlorpyrifos oxon, the toxic metabolite of the OP pesticide chlorpyrifos. In the second model, mice were infected with an adenovirus that induced expression of HuPON1 and then exposed to sequential doses of GD. VX, or (as reported previously) diazoxon, the toxic metabolite of the OP pesticide diazinon. In both animal models, the exogenously added HuPON1 protected animals against otherwise lethal doses of the OP pesticides but not against the nerve agents. Together, the results support prior modeling and in vitro activity data which suggest that wild-type HuPON1 does not have sufficient catalytic activity to provide in vivo protection against nerve agents. Published by Elsevier Ireland Ltd. C1 [Hodgins, Sean M.; Kasten, Shane A.; Harrison, Joshua; Otto, Tamara C.; Oliver, Zeke P.; Rezk, Peter; Reeves, Tony E.; Chilukuri, Nageswararao; Cerasoli, Douglas M.] USA, Med Res Inst Chem Def, Div Res, Physiol & Immunol Branch, Aberdeen Proving Ground, MD 21010 USA. RP Cerasoli, DM (reprint author), USA, Med Res Inst Chem Def, Div Res, Physiol & Immunol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM douglas.cerasoli@us.army.mil FU Defense Threat Reduction Agency-Joint Science and Technology Office, Medical ST Division; US Army Medical Research Institute of Chemical Defense FX This work was supported by the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S&T Division. S.M.H., S.A.K, J.L.H., T.C.O., Z.P.O., P.E.K., and T.E.R. were supported in part by an appointment to the Internship/Research Participation Program for the US Army Medical Research Institute of Chemical Defense, administered by the Oak Ridge Institute for Science and Education through an agreement between the US Department of Energy and the USAMRICD. NR 24 TC 10 Z9 10 U1 0 U2 14 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 EI 1872-7786 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD MAR 25 PY 2013 VL 203 IS 1 SI SI BP 177 EP 180 DI 10.1016/j.cbi.2012.10.015 PG 4 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 134HU UT WOS:000318201800036 PM 23123254 ER PT J AU Kirby, SD Norris, JR Smith, JR Bahnson, BJ Cerasoli, DM AF Kirby, Stephen D. Norris, Joseph R. Smith, J. Richard Bahnson, Brian J. Cerasoli, Douglas M. TI Human paraoxonase double mutants hydrolyze V and G class organophosphorus nerve agents SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT International Meeting on Cholinesterases CY JUN 04-09, 2012 CL Kazan, RUSSIA DE Human; Paraoxonase; PON1; Organophosphorus; OP; Nerve agent ID HUMAN SERUM PARAOXONASE; RHESUS-MONKEYS; BUTYRYLCHOLINESTERASE; STEREOISOMERS AB Variants of human paraoxonase 1 (PON1) are being developed as catalytic bioscavengers for the organophosphorus chemical warfare agents (OP). It is preferable that the new PON1 variants have broad spectrum hydrolase activities to hydrolyze both G- and V-class OPs. H115W PON1 has shown improvements over wild type PON1 in its capacity to hydrolyze some OP compounds. We improved upon these activities either by substituting a tryptophan (F347W) near the putative active site residues for enhanced substrate binding or by reducing a bulky group (Y71A) at the periphery of the putative enzyme active site. When compared to H115W alone, we found that H115W/Y71A and H115W/F347W maintained VX catalytic efficiency but showed mixed results for the capacity to hydrolyze paraoxon. Testing our double mutants against racemic sarin, we observed reduced values of Km for H115W/F347W that modestly improved catalytic efficiency over wild type and H115W. Contrary to previous reports, we show that H115W can hydrolyze soman, and the double mutant H115W/Y71A is nearly 4-fold more efficient than H115W for paraoxon hydrolysis. We also observed modest stereoselectivity for hydrolysis of the P(-) stereoisomer of tabun by H115W/F347W. These data demonstrate enhancements made in PON1 for the purpose of developing an improved catalytic bioscavenger to protect cholinesterase against chemical warfare agents. Published by Elsevier Ireland Ltd. C1 [Kirby, Stephen D.; Norris, Joseph R.; Smith, J. Richard; Cerasoli, Douglas M.] USA, Med Res Inst Chem Def, Div Res, Physiol & Immunol Branch, Aberdeen Proving Ground, MD 21010 USA. [Kirby, Stephen D.; Bahnson, Brian J.] Univ Delaware, Dept Chem & Biochem, Newark, DE 19716 USA. RP Kirby, SD (reprint author), USA, Med Res Inst Chem Def, Div Res, Physiol & Immunol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM stephen.drew.kirby@us.army.mil FU Defense Threat Reduction Agency - Joint Science and Technology Office, Medical ST Division [1.D0019_08_RC_C] FX The views expressed in this article are those of the author(s) and do not reflect the official policy of the Department of Army, Department of Defense, or the US Government. This research was supported by the Defense Threat Reduction Agency - Joint Science and Technology Office, Medical S&T Division, under project 1.D0019_08_RC_C. NR 13 TC 12 Z9 13 U1 2 U2 35 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 EI 1872-7786 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD MAR 25 PY 2013 VL 203 IS 1 SI SI BP 181 EP 185 DI 10.1016/j.cbi.2012.10.023 PG 5 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 134HU UT WOS:000318201800037 PM 23159884 ER PT J AU Otto, TC Scott, JR Kauffman, MA Hodgins, SM diTargiani, RC Hughes, JH Sarricks, EP Saturday, GA Hamilton, TA Cerasoli, DM AF Otto, Tamara C. Scott, Jennifer R. Kauffman, Monika A. Hodgins, Sean M. diTargiani, Robert C. Hughes, James H. Sarricks, Erin P. Saturday, Greg A. Hamilton, Tracey A. Cerasoli, Douglas M. TI Identification and characterization of novel catalytic bioscavengers of organophosphorus nerve agents SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT International Meeting on Cholinesterases CY JUN 04-09, 2012 CL Kazan, RUSSIA DE Organophosphorus; Nerve agent; Catalytic bioscavenger; Micromonospora aurantiaca ID TOKYO SUBWAY; TOXICITY; SOMAN AB In an effort to discover novel catalytic bioscavengers of organophosphorus (OP) nerve agents, cell lysates from a diverse set of bacterial strains were screened for their capacity to hydrolyze the OP nerve agents VX. VR., and soman (GD). The library of bacterial strains was identified using both random and rational approaches. Specifically, two representative strains from eight categories of extremophiles were chosen at random. For the rational approach, the protein sequence of organophosphorus hydrolase (OPH) from Brevundimonas diminuta was searched against a non-redundant protein database using the Basic Local Alignment Search Tool to find regions of local similarity between sequences. Over 15 protein sequences with significant sequence similarity to OPH were identified from a variety of bacterial strains. Some of these matches were based on predicted protein structures derived from bacterial genome sequences rather than from bona fide proteins isolated from bacteria. Of the 25 strains selected for nerve agent testing, three bacterial strains had measurable levels of OP hydrolase activity. These strains are Ammoniphilus oxalaticus, Haloarcula sp., and Micromonospora aurantiaca. Lysates from A. oxalaticus had detectable hydrolysis of VR; Haloarcula sp. had appreciable hydrolysis of VX and VR, whereas lysates from M. aurantiaca had detectable hydrolysis of VR and GD. Published by Elsevier Ireland Ltd. C1 [Otto, Tamara C.] USA, Med Res Inst Chem Def, Neurobehav Toxicol Branch, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA. [Scott, Jennifer R.; Kauffman, Monika A.; Hodgins, Sean M.; diTargiani, Robert C.; Cerasoli, Douglas M.] USA, Med Res Inst Chem Def, Physiol & Immunol Branch, Div Res, Aberdeen Proving Ground, MD 21010 USA. [Hughes, James H.; Sarricks, Erin P.; Saturday, Greg A.; Hamilton, Tracey A.] USA, Med Res Inst Chem Def, Comparat Pathol Branch, Res Support Div, Aberdeen Proving Ground, MD 21010 USA. RP Otto, TC (reprint author), USA, Med Res Inst Chem Def, Neurobehav Toxicol Branch, Analyt Toxicol Div, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM tamara.c.otto@us.army.mil FU Defense Threat Reduction Agency-Joint Science and Technology Office, Medical ST Division FX We gratefully acknowledge Drs. Ann Hirsch and Nancy Fujishige (UCLA) for helpful comments regarding the growth of M. aurantiaca as well as sharing unpublished results. This work was supported by the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S&T Division. J.R.S., M.A.K., S.M.H., and R.C.D. were supported in part by an appointment to the Internship/Research Participation Program for the U.S. Army Medical Re search Institute of Chemical Defense, administered by the Oak Ridge Institute for Science and Education and the USAMRICD. The views expressed in this manuscript are those of the authors and do not reflect the official policy of the Department of Army, Department of Defense, or the U.S. Government. NR 12 TC 8 Z9 9 U1 1 U2 24 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 EI 1872-7786 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD MAR 25 PY 2013 VL 203 IS 1 SI SI BP 186 EP 190 DI 10.1016/j.cbi.2012.09.009 PG 5 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 134HU UT WOS:000318201800038 PM 23041042 ER PT J AU Aleti, V Reddy, GB Parikh, K Arun, P Chilukuri, N AF Aleti, Vineela Reddy, Gireesh B. Parikh, Kalpana Arun, Peethambaran Chilukuri, Nageswararao TI Persistent and high-level expression of human liver prolidase in vivo in mice using adenovirus SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT International Meeting on Cholinesterases CY JUN 04-09, 2012 CL Kazan, RUSSIA DE Human liver prolidase; Adenovirus; Gene delivery; Chemical warfare nerve agents; Catalytic bioscavenger ID NERVE AGENT TOXICITY; GENE-TRANSFER; PROTECTION; PURIFICATION AB Human liver prolidase, a metal-dependent dipeptidase, is being tested as a potential catalytic bioscavenger against organophosphorus (OP) chemical warfare nerve agents. The purpose of this study was to determine whether persistent and high-levels of biologically active and intact recombinant human (rHu) prolidase could be introduced in vivo in mice using adenovirus (Ad). Here, we report that a single intravenous injection of Ad containing the prolidase gene with a 6x histidine-tag (Ad-prolidase) introduced high-levels of rHu prolidase in the circulation of mice which peaked on days 5-7 at 159 +/- 129 U/mL This level of prolidase is 120 times greater than that of the enzyme level in mice injected with Ad-null virus. To determine if all of Ad-prolidase-produced rHu prolidase was exported into the circulation, enzyme activity was measured in a variety of tissues. Liver contained the highest levels of rHu prolidase on day 7 (5647 454 U/g) compared to blood or any other tissue. Recombinant Hu prolidase hydrolyzed DFP, a simulant of OP nerve agents, in vitro. In vivo, prolidase overexpression extended the survival of 4 out of 6 mice by 4-8 h against exposure to two 1 x LD50 doses of DFP. In contrast, overexpression of mouse butyrylcholinesterase (BChE), a proven stoichiometric bioscavenger of OP compounds, protected 5 out of 6 mice from DFP lethality and surviving mice showed no symptoms of DFP toxicity. In conclusion, the results suggest that gene delivery using Ad is capable of introducing persistent and high levels of human liver prolidase in vivo. The gene-delivered prolidase hydrolyzed DFP in vitro but provided only modest protection in vivo in mice, delaying the death of the animals by only 4-8 h. Published by Elsevier Ireland Ltd. C1 [Aleti, Vineela; Reddy, Gireesh B.; Parikh, Kalpana; Arun, Peethambaran; Chilukuri, Nageswararao] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. RP Chilukuri, N (reprint author), USA, Med Res Inst Chem Def, Div Res, Physiol & Immunol Branch,USAMRICD, 3100 Rickets Point Rd, Edgewood, MD 21010 USA. EM Nageswararao.chilukuri@us.army.mil OI Reddy, Gireesh/0000-0001-6112-2309 FU Defense Threat Reduction Agency - Joint Science and Technology Office, Medical ST Division [1. D0003_09_RC_C] FX This research was supported by the Defense Threat Reduction Agency - Joint Science and Technology Office, Medical S&T Division (Project # 1. D0003_09_RC_C). We thank Drs. Douglas M. Cerasoli, Carolyn P. Chambers, and Brian M. Keyser and CPT Carl Smith for critical evaluation of the manuscript. We also thank the staff at Washington Biotechnology Inc., Columbia, MD for their technical help with the animal experiments. NR 14 TC 3 Z9 3 U1 1 U2 19 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 EI 1872-7786 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD MAR 25 PY 2013 VL 203 IS 1 SI SI BP 191 EP 195 DI 10.1016/j.cbi.2012.08.021 PG 5 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 134HU UT WOS:000318201800039 PM 22982776 ER PT J AU Valiyaveettil, M Alamneh, YA Miller, SA Hammamieh, R Arun, P Wang, Y Wei, YL Oguntayo, S Long, JB Nambiar, MP AF Valiyaveettil, Manojkumar Alamneh, Yonas A. Miller, Stacey-Ann Hammamieh, Rasha Arun, Peethambaran Wang, Ying Wei, Yanling Oguntayo, Samuel Long, Joseph B. Nambiar, Madhusoodana P. TI Modulation of cholinergic pathways and inflammatory mediators in blast-induced traumatic brain injury SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT International Meeting on Cholinesterases CY JUN 04-09, 2012 CL Kazan, RUSSIA DE Repeated blast exposure; Cholinergic pathway; Inflammation; Acetylcholinisterase; Micro RNA; Traumatic brain injury ID ANTIINFLAMMATORY PATHWAY; ACETYLCHOLINESTERASE ACTIVITY; LUNG TRAUMA; STRESS; MODEL; BLOOD; MICRORNAS; EXPOSURE; MOUSE; RATS AB Cholinergic activity has been recognized as a major regulatory component of stress responses after traumatic brain injury (TB!). Centrally acting acetylcholinesterase (AChE) inhibitors are also being considered as potential therapeutic candidates against TBI mediated cognitive impairments. We have evaluated the expression of molecules involved in cholinergic and inflammatory pathways in various regions of brain after repeated blast exposures in mice. Isoflurane anesthetized C57BL/6J mice were restrained and placed in a prone position transverse to the direction of the shockwaves and exposed to three 20.6 psi blast overpressures with 1-30 min intervals. Brains were collected at the 6 h time point after the last blast exposure and subjected to cDNA microarray and microRNA analysis. cDNA microarray analysis showed significant changes in the expression of cholinergic (muscarinic and nicotinic) and gammaaminobutyric acid and glutamate receptors in the midbrain region along with significant changes in multiple genes involved in inflammatory pathways in various regions of the brain. MicroRNA analysis of cerebellum revealed differential expression of miR-132 and 183, which are linked to cholinergic anti-inflammatory signaling, after blast exposure. Changes in the expression of myeloperoxidase in the cerebellum were confirmed by Western blotting. These results indicate that early pathologic progression of blast TBI involves dysregulation of cholinergic and inflammatory pathways related genes. Acute changes in molecules involved in the modulation of cholinergic and inflammatory pathways after blast TBI can cause long-term central and peripheral pathophysiological changes. (C) 2012 Published by Elsevier Ireland Ltd. C1 [Valiyaveettil, Manojkumar; Alamneh, Yonas A.; Arun, Peethambaran; Wang, Ying; Wei, Yanling; Oguntayo, Samuel; Long, Joseph B.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Miller, Stacey-Ann; Hammamieh, Rasha] USA, Ctr Environm Hlth Res, Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP Valiyaveettil, M (reprint author), Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. EM m.valiyaveettil@amedd.army.mil; madhu-soodana.nambiar@amedd.army.mil NR 31 TC 13 Z9 16 U1 0 U2 16 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 EI 1872-7786 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD MAR 25 PY 2013 VL 203 IS 1 SI SI BP 371 EP 375 DI 10.1016/j.cbi.2012.10.022 PG 5 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 134HU UT WOS:000318201800074 PM 23159883 ER PT J AU Filone, CM Hodges, EN Honeyman, B Bushkin, GG Boyd, K Platt, A Ni, F Strom, K Hensley, L Snyder, JK Connor, JH AF Filone, Claire Marie Hodges, Erin N. Honeyman, Brian Bushkin, G. Guy Boyd, Karla Platt, Andrew Ni, Feng Strom, Kyle Hensley, Lisa Snyder, John K. Connor, John H. TI Identification of a Broad-Spectrum Inhibitor of Viral RNA Synthesis: Validation of a Prototype Virus-Based Approach SO CHEMISTRY & BIOLOGY LA English DT Article ID VESICULAR STOMATITIS-VIRUS; DIVERSITY-ORIENTED SYNTHESIS; MAJOR SURFACE GLYCOPROTEIN; MONOCLONAL-ANTIBODIES; ANTIVIRAL DRUG; EBOLA-VIRUS; REPLICATION; RIBAVIRIN; TRANSCRIPTION; MUTATIONS AB There are no approved therapeutics for the most deadly nonsegmented negative-strand (NNS) RNA viruses, including Ebola (EBOV). To identify chemical scaffolds for the development of broad-spectrum antivirals, we undertook a prototype-based lead identification screen. Using the prototype NNS virus, vesicular stomatitis virus (VSV), multiple inhibitory compounds were identified. Three compounds were investigated for broad-spectrum activity and inhibited EBOV infection. The most potent, CMLDBU3402, was selected for further study. CMLDBU3402 did not show significant activity against segmented negative-strand RNA viruses, suggesting proscribed broad-spectrum activity. Mechanistic analysis indicated that CMLDBU3402 blocked VSV viral RNA synthesis and inhibited EBOV RNA transcription, demonstrating a consistent mechanism of action against genetically distinct viruses. The identification of this chemical backbone as a broad-spectrum inhibitor of viral RNA synthesis offers significant potential for the development of new therapies for highly pathogenic viruses. C1 [Filone, Claire Marie; Hodges, Erin N.; Honeyman, Brian; Bushkin, G. Guy; Boyd, Karla; Platt, Andrew; Connor, John H.] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA. [Ni, Feng; Strom, Kyle; Snyder, John K.] Boston Univ, Dept Chem, Boston, MA 02118 USA. [Ni, Feng; Strom, Kyle; Snyder, John K.] Boston Univ, Ctr Chem Methodol & Lib Dev CMLD BU, Boston, MA 02118 USA. [Filone, Claire Marie; Hensley, Lisa] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. RP Connor, JH (reprint author), Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA. EM jhconnor@bu.edu OI Filone, Claire Marie/0000-0002-4041-3948; Connor, John/0000-0002-8867-7256 FU Postgraduate Research Participation Program; U.S. Army Research and Medical Command; NIH [RO1AI1096159-01, K22AI-064606]; [P41 086180] FX We would like to thank Darci Smith for assistance with the RVFV experiment, Aaron Beeler for his help in coordinating CMLD compound screening, and Sean Whelan for sharing the VSV minigenome system. We thank Elke Muhlberger for use of the EBOV minigenome system. C.M.F. was supported by the Postgraduate Research Participation Program and the U.S. Army Research and Medical Command administered by the Oak Ridge Institute for Science and Education (ORISE). This work was supported in part by P41 086180 and also in part by NIH RO1AI1096159-01 and K22AI-064606 (to J.H.C.). We thank NSF for supporting the purchase of the NMR (CHE 0619339) and HRMS (CHE 0443618) spectrometers. NR 29 TC 9 Z9 10 U1 0 U2 13 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 1074-5521 J9 CHEM BIOL JI Chem. Biol. PD MAR 21 PY 2013 VL 20 IS 3 BP 424 EP 433 DI 10.1016/j.chembiol.2013.02.011 PG 10 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 115RT UT WOS:000316830300014 PM 23521799 ER PT J AU Serrano, MD Cascales, C Han, XM Zaldo, C Jezowski, A Stachowiak, P Ter-Gabrielyan, N Fromzel, V Dubinskii, M AF Dolores Serrano, Maria Cascales, Concepcion Han, Xiumei Zaldo, Carlos Jezowski, Andrzej Stachowiak, Piotr Ter-Gabrielyan, Nikolay Fromzel, Viktor Dubinskii, Mark TI Thermal Characterization, Crystal Field Analysis and In-Band Pumped Laser Performance of Er Doped NaY(WO4)(2) Disordered Laser Crystals SO PLOS ONE LA English DT Article ID LOCAL DISORDER; MU-M; DIODE; OPERATION; ABSORPTION; NM AB Undoped and Er-doped NaY(WO4)2 disordered single crystals have been grown by the Czochralski technique. The specific heat and thermal conductivity (k) of these crystals have been characterized from T = 4 K to 700 K and 360 K, respectively. It is shown that k exhibits anisotropy characteristic of single crystals as well as a k(T) behavior observed in glasses, with a saturation mean free phonon path of 3.6 angstrom and 4.5 angstrom for propagation along a and c crystal axes, respectively. The relative energy positions and irreducible representations of Stark Er3+ levels up to (4)G7/2 multiplet have been determined by the combination of experimental low (, 10 K) temperature optical absorption and photoluminescence measurements and simulations with a single-electron Hamiltonian including both free-ion and crystal field interactions. Absorption, emission and gain cross sections of the I-4(13/2) < > I-4(15/2) laser related transition have been determined at 77 K. The I-4(13/2) Er3+ lifetime (tau) was measured in the temperature range of 77-300 K, and was found to change from tau (77K) approximate to 4.5 ms to tau (300K) approximate to 3.5 ms. Laser operation is demonstrated at 77 K and 300 K by resonantly pumping the I-4(13/2) multiplet at lambda approximate to 1500 nm with a broadband (FWHM approximate to 20 nm) diode laser source perfectly matching the 77 K crystal I-4(15/2) -> R I-4(13/2) absorption profile. At 77 K as much as 5.5 W of output power were obtained in pi-polarized configuration with a slope efficiency versus absorbed pump power of 57%, the free running laser wavelength in air was lambda approximate to 1611 nm with the laser output bandwidth of 3.5 nm. The laser emission was tunable over 30.7 nm, from 1590.7 nm to 1621.4 nm, for the same pi-polarized configuration. C1 [Dolores Serrano, Maria; Cascales, Concepcion; Han, Xiumei; Zaldo, Carlos] CSIC, Inst Ciencia Mat Madrid, Dept Photon Mat, Madrid, Spain. [Jezowski, Andrzej; Stachowiak, Piotr] Polish Acad Sci, Inst Low Temp & Struct Res, Div Low Temp & Superconduct, Wroclaw, Poland. [Ter-Gabrielyan, Nikolay; Fromzel, Viktor; Dubinskii, Mark] USA, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD USA. RP Zaldo, C (reprint author), CSIC, Inst Ciencia Mat Madrid, Dept Photon Mat, Madrid, Spain. EM cezaldo@icmm.csic.es RI CASCALES, CONCHITA/C-3930-2011; Zalldo, Carlos/K-4321-2013; Serrano, Maria Dolores/B-9629-2013 OI CASCALES, CONCHITA/0000-0003-2513-5887; FU USAITC [W911NF-10-1-0234]; Spanish Ministry of Economy and Competitiveness [MAT2011-29255-C02-01] FX This work has been partially supported by the USAITC W911NF-10-1-0234 contract and by the Spanish Ministry of Economy and Competitiveness under project MAT2011-29255-C02-01. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 31 TC 1 Z9 1 U1 0 U2 38 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 21 PY 2013 VL 8 IS 3 AR e59381 DI 10.1371/journal.pone.0059381 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 111UM UT WOS:000316546400036 PM 23555664 ER PT J AU Nelson, DA Curran, AR Nyberg, HA Marttila, EA Mason, PA Ziriax, JM AF Nelson, David A. Curran, Allen R. Nyberg, Hans A. Marttila, Eric A. Mason, Patrick A. Ziriax, John M. TI High-resolution simulations of the thermophysiological effects of human exposure to 100 MHz RF energy SO PHYSICS IN MEDICINE AND BIOLOGY LA English DT Article ID CORE TEMPERATURE ELEVATION; HUMAN VOLUNTEERS; ABSORPTION RATE; HUMAN-BODY; LOCOREGIONAL HYPERTHERMIA; DIELECTRIC-PROPERTIES; BIOLOGICAL TISSUES; ESOPHAGEAL CANCER; FDTD CALCULATIONS; VOXEL MODEL AB Human exposure to radio frequency (RF) electromagnetic energy is known to result in tissue heating and can raise temperatures substantially in some situations. Standards for safe exposure to RF do not reflect bio-heat transfer considerations however. Thermoregulatory function (vasodilation, sweating) may mitigate RF heating effects in some environments and exposure scenarios. Conversely, a combination of an extreme environment (high temperature, high humidity), high activity levels and thermally insulating garments may exacerbate RF exposure and pose a risk of unsafe temperature elevation, even for power densities which might be acceptable in a normothermic environment. A high-resolution thermophysiological model, incorporating a heterogeneous tissue model of a seated adult has been developed and used to replicate a series of whole-body exposures at a frequency (100 MHz) which approximates that of human whole-body resonance. Exposures were simulated at three power densities (4, 6 and 8 mW cm(-2)) plus a sham exposure and at three different ambient temperatures (24, 28 and 31 degrees C). The maximum hypothalamic temperature increase over the course of a 45 min exposure was 0.28 degrees C and occurred in the most extreme conditions (T-amb = 31 degrees C, PD = 8 mW cm(-2)). Skin temperature increases attributable to RF exposure were modest, with the exception of a 'hot spot' in the vicinity of the ankle where skin temperatures exceeded 39 degrees C. Temperature increases in internal organs and tissues were small, except for connective tissue and bone in the lower leg and foot. Temperature elevation also was noted in the spinal cord, consistent with a hot spot previously identified in the literature. C1 [Nelson, David A.] Univ S Alabama, Dept Mech Engn, Mobile, AL 36688 USA. [Curran, Allen R.; Nyberg, Hans A.; Marttila, Eric A.] ThermoAnalyt Inc, Calumet, MI 49913 USA. [Mason, Patrick A.] USA, Res Lab, Directed Energy Bioeffects Div, Radiofrequency Radiat Branch, Brooks City Base, TX 78235 USA. [Ziriax, John M.] Naval Med Res Unit San Antonio, Brooks City Base, TX 78235 USA. RP Nelson, DA (reprint author), Univ S Alabama, Dept Mech Engn, Mobile, AL 36688 USA. EM danelson@southalabama.edu NR 40 TC 4 Z9 4 U1 1 U2 9 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0031-9155 J9 PHYS MED BIOL JI Phys. Med. Biol. PD MAR 21 PY 2013 VL 58 IS 6 BP 1947 EP 1968 DI 10.1088/0031-9155/58/6/1947 PG 22 WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Radiology, Nuclear Medicine & Medical Imaging GA 100WL UT WOS:000315735400018 PM 23459448 ER PT J AU Carlson, LA Kenefick, RW Koch, AJ AF Carlson, Lara A. Kenefick, Robert W. Koch, Alexander J. TI Influence of carbohydrate ingestion on salivary immunoglobulin A following resistance exercise SO JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION LA English DT Article DE Carbohydrate; Immunoglobulin (IgA); Cytokines; Immune response; Resistance exercise ID INTENSE INTERVAL EXERCISE; ECCENTRIC EXERCISE; CYTOKINE RESPONSE; IMMUNE-RESPONSES; REPEATED BOUTS; ALPHA-AMYLASE; FLOW-RATE; 2 H; IGA; SUPPLEMENTATION AB Background: Heavy exercise stresses immune function, however carbohydrate (CHO) supplementation has been shown to attenuate the decline in some measures of immune function after exercise. The purpose of the study was to investigate the impact of CHO supplementation on salivary immunoglobulin A (s-IgA) levels, interleukin 2 (IL-2), and interleukin 5 (IL-5), following an acute bout of resistance exercise (RE). Methods: Ten resistance trained male collegiate athletes (21 +/- 2 yr; 174 +/- 6 cm, 80 +/- 11kg, 14%+/- 4% fat) performed RE consisting of four exercises (leg press, lat pull-downs, bench press, and leg curls). Volunteers performed four sets of 10 repetitions at 65% of 1-RM, with 2 min rest between sets for all exercises. Subjects consumed either CHO beverage (1 g.kg(-1) body weight) or placebo (P) prior to, during, and after RE (randomized, double blind design). Saliva and venous blood were collected pre-, post-and 90 min post-exercise. Results: No change occurred in s-IgA from rest relative to osmolality or as a secretion rate (p > 0.05). IL-2 levels were unchanged by exercise in both trials (time effect p = 0.342). IL-5 was significantly (time effect p = 0.04) decreased between rest (1.55 +/- 0.07 pg.ml(-1)) and 90 min post-exercise (0.96 +/- 0.11 pg.ml(-1)), with no difference between treatments (group x time effect p = 0.610). There was no time-by-treatment interaction (p < 0.05) observed between CHO and P treatments for s-IgA or IL-5. Conclusion: IL-5 decreases after RE, but s-IgA and IL-2 levels remain stable. CHO ingestion prior to-, during or following RE did not appear to alter salivary immune responses. C1 [Carlson, Lara A.] Univ New England, Biddeford, ME 04005 USA. [Kenefick, Robert W.] US Army, Environm Med Res Inst, Natick, MA USA. [Koch, Alexander J.] Lenoir Rhyne Univ, Hickory, NC USA. RP Carlson, LA (reprint author), Univ New England, 11 Hills Beach Rd Pickus Biomed Ctr 209, Biddeford, ME 04005 USA. EM lcarlson@une.edu FU INBRE Program of the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH) [P20 RR16462] FX The views, opinions, and findings in this report are those of the authors and should not be construed as official Department of the Army position, policy, or decision unless so designated by other official designation. All experiments were carried out in accordance to state and federal guidelines. This publication was made possible by the Vermont Genetics Network through Grant Number P20 RR16462 from the INBRE Program of the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of NCRR or NIH. The authors would like to thank all the men who participated in this exercise study. NR 41 TC 2 Z9 2 U1 1 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1550-2783 J9 J INT SOC SPORT NUTR JI J. Int. Soc. Sport Nutr. PD MAR 20 PY 2013 VL 10 AR 14 DI 10.1186/1550-2783-10-14 PG 8 WC Nutrition & Dietetics; Sport Sciences SC Nutrition & Dietetics; Sport Sciences GA 190YA UT WOS:000322378300001 PM 23514330 ER PT J AU Dorsey, WM Zaghloul, AI AF Dorsey, William Mark Zaghloul, Amir I. TI Dual-band, dual-circularly polarised antenna element SO IET MICROWAVES ANTENNAS & PROPAGATION LA English DT Article ID RECONFIGURABLE MICROSTRIP ANTENNA; DIVERSITY AB A dual-band element that operates with dual-circular polarisation in two separate industrial, scientific and medical bands is presented. The design that is based on concentric square slot/shorted-ring configuration is realisable in cost-effective printed circuit board technology making it attractive for low-cost personal communications devices. The antenna element provides a flexible topology that allows for convenient, independent control of the polarisation and impedance bandwidth of two distinct frequency bands with no fundamental limitation on the ratio between the high-and low-band frequency ranges. The topology of this element is presented, and the antenna concept is validated via simulated and measured results. C1 [Dorsey, William Mark] USN, Res Lab, Div Radar, Washington, DC 20375 USA. [Dorsey, William Mark; Zaghloul, Amir I.] Virginia Polytech Inst & State Univ, Bradley Dept Elect & Comp Engn, Falls Church, VA 22043 USA. [Zaghloul, Amir I.] USA, Res Lab ARL, Adelphi, MD 20783 USA. RP Dorsey, WM (reprint author), USN, Res Lab, Div Radar, Washington, DC 20375 USA. EM wmdorsey@vt.edu NR 18 TC 6 Z9 6 U1 2 U2 16 PU INST ENGINEERING TECHNOLOGY-IET PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 1751-8725 EI 1751-8733 J9 IET MICROW ANTENNA P JI IET Microw. Antennas Propag. PD MAR 19 PY 2013 VL 7 IS 4 BP 283 EP 290 DI 10.1049/iet-map.2012.0625 PG 8 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 181YH UT WOS:000321706200009 ER PT J AU Chen, L Walker, PM Geissel, H Litvinov, YA Beckert, K Beller, P Bosch, F Boutin, D Caceres, L Carroll, JJ Cullen, DM Cullen, IJ Franzke, B Gerl, J Gorska, M Jones, GA Kishada, A Knobel, R Kozhuharov, C Kurcewicz, J Litvinov, SA Liu, Z Mandal, S Montes, F Munzenberg, G Nolden, F Ohtsubo, T Patyk, Z Plass, WR Podolyak, Z Rigby, S Saito, N Saito, T Scheidenberger, C Simpson, EC Shindo, M Steck, M Sun, B Williams, SJ Weick, H Winkler, M Wollersheim, HJ Yamaguchi, T AF Chen, L. Walker, P. M. Geissel, H. Litvinov, Yu. A. Beckert, K. Beller, P. Bosch, F. Boutin, D. Caceres, L. Carroll, J. J. Cullen, D. M. Cullen, I. J. Franzke, B. Gerl, J. Gorska, M. Jones, G. A. Kishada, A. Knoebel, R. Kozhuharov, C. Kurcewicz, J. Litvinov, S. A. Liu, Z. Mandal, S. Montes, F. Muenzenberg, G. Nolden, F. Ohtsubo, T. Patyk, Z. Plass, W. R. Podolyak, Zs Rigby, S. Saito, N. Saito, T. Scheidenberger, C. Simpson, E. C. Shindo, M. Steck, M. Sun, B. Williams, S. J. Weick, H. Winkler, M. Wollersheim, H. -J. Yamaguchi, T. TI Direct Observation of Long-Lived Isomers in Bi-212 SO PHYSICAL REVIEW LETTERS LA English DT Article ID FRS-ESR FACILITY; NUCLEAR-PHYSICS; DECAY; NUCLEOSYNTHESIS; DEPLETION; STATES; GSI AB Long-lived isomers in Bi-212 have been studied following U-238 projectile fragmentation at 670 MeV per nucleon. The fragmentation products were injected as highly charged ions into a storage ring, giving access to masses and half-lives. While the excitation energy of the first isomer of Bi-212 was confirmed, the second isomer was observed at 1478(30) keV, in contrast to the previously accepted value of >1910 keV. It was also found to have an extended Lorentz-corrected in-ring half-life >30 min, compared to 7.0 (3) min for the neutral atom. Both the energy and half-life differences can be understood as being due a substantial, though previously unrecognized, internal decay branch for neutral atoms. Earlier shell-model calculations are now found to give good agreement with the isomer excitation energy. Furthermore, these and new calculations predict the existence of states at slightly higher energy that could facilitate isomer deexcitation studies. DOI: 10.1103/PhysRevLett.110.122502 C1 [Chen, L.; Geissel, H.; Litvinov, Yu. A.; Beckert, K.; Beller, P.; Bosch, F.; Boutin, D.; Caceres, L.; Franzke, B.; Gerl, J.; Gorska, M.; Knoebel, R.; Kozhuharov, C.; Kurcewicz, J.; Litvinov, S. A.; Mandal, S.; Muenzenberg, G.; Nolden, F.; Saito, N.; Saito, T.; Scheidenberger, C.; Steck, M.; Sun, B.; Weick, H.; Winkler, M.; Wollersheim, H. -J.] GSI Helmholtzzentrum Schwerionenforsch, D-64291 Darmstadt, Germany. [Chen, L.; Geissel, H.; Plass, W. R.; Scheidenberger, C.] Univ Giessen, Inst Phys 2, D-35392 Giessen, Germany. [Chen, L.] Texas A&M Univ, Inst Cyclotron, College Stn, TX 77843 USA. [Walker, P. M.; Cullen, I. J.; Jones, G. A.; Liu, Z.; Podolyak, Zs; Simpson, E. C.; Williams, S. J.] Univ Surrey, Dept Phys, Guildford GU2 7XH, Surrey, England. [Litvinov, Yu. A.] Max Planck Inst Kernphys, D-69117 Heidelberg, Germany. [Carroll, J. J.] USA, Res Lab, Adelphi, MD 20783 USA. [Cullen, D. M.; Kishada, A.; Rigby, S.] Univ Manchester, Schuster Lab, Manchester M13 9PL, Lancs, England. [Liu, Z.] Univ Edinburgh, Sch Phys & Astron, Edinburgh EH9 3JZ, Midlothian, Scotland. [Montes, F.] Michigan State Univ, E Lansing, MI 48824 USA. [Ohtsubo, T.] Niigata Univ, Dept Phys, Niigata 9502181, Japan. [Patyk, Z.] Natl Ctr Nucl Res, PL-00681 Warsaw, Poland. [Shindo, M.] Univ Tokyo, Dept Phys, Tokyo 1130033, Japan. [Yamaguchi, T.] Saitama Univ, Grad Sch Sci & Engn, Saitama 3388570, Japan. RP Chen, L (reprint author), GSI Helmholtzzentrum Schwerionenforsch, Planckstr 1, D-64291 Darmstadt, Germany. RI CHEN, LIXIN/G-3405-2013; Sun, Baohua/C-6823-2009 OI Sun, Baohua/0000-0001-9868-5711 FU Helmholtz Association of German Research Centers [VH-NG-033]; UK STFC; AWE plc.; [NSFC-11105010]; [NCET-09-0031] FX We thank the technical staff of the accelerators, the FRS, and the target laboratory for their valuable contributions to the beam quality and experimental setups. We also thank the Helmholtz Association of German Research Centers (VH-NG-033), and the UK STFC and AWE plc. for their support. B. S. acknowledges Grants No. NSFC-11105010 and No. NCET-09-0031. NR 34 TC 11 Z9 12 U1 0 U2 29 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD MAR 19 PY 2013 VL 110 IS 12 AR 122502 DI 10.1103/PhysRevLett.110.122502 PG 5 WC Physics, Multidisciplinary SC Physics GA 109WF UT WOS:000316399800007 PM 25166798 ER PT J AU Belenky, G Wang, D Lin, YX Donetsky, D Kipshidze, G Shterengas, L Westerfeld, D Sarney, WL Svensson, SP AF Belenky, Gregory Wang, Ding Lin, Youxi Donetsky, Dmitry Kipshidze, Gela Shterengas, Leon Westerfeld, David Sarney, Wendy L. Svensson, Stefan P. TI Metamorphic InAsSb/AlInAsSb heterostructures for optoelectronic applications SO APPLIED PHYSICS LETTERS LA English DT Article ID DEVICES AB Metamorphic heterostructures containing bulk InAs1-xSbx layers and AlInAsSb barriers were grown on GaSb substrates. The lattice mismatch (up to 2.1%) between the GaSb substrates and the InAsSb layers was accommodated by the growth of GaInSb linearly graded buffers. The 1 mu m thick InAsSb0.44 layer with an absorption edge above 9 mu m exhibited an in-plane residual strain of about 0.08%. InAs1-xSbx structures with x = 0.2 and x = 0.44 operated as light emitting diodes at 80K demonstrated output powers of 90 mu W and 8 mu W at 5 mu m and 8 mu m, respectively. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4796181] C1 [Belenky, Gregory; Wang, Ding; Lin, Youxi; Donetsky, Dmitry; Kipshidze, Gela; Shterengas, Leon; Westerfeld, David] SUNY Stony Brook, Dept ECE, Stony Brook, NY 11794 USA. [Sarney, Wendy L.; Svensson, Stefan P.] USA, Res Lab, Adelphi, MD 20783 USA. RP Belenky, G (reprint author), SUNY Stony Brook, Dept ECE, Stony Brook, NY 11794 USA. OI LIN, YOUXI/0000-0002-9092-2302 FU US National Science Foundation [DMR1160843]; US Army Research Office [W911NF1110109, W911NF1220057] FX This work was supported by US National Science Foundation through grant (No. DMR1160843) and US Army Research Office through grants (Nos. W911NF1110109 and W911NF1220057). NR 15 TC 15 Z9 15 U1 4 U2 50 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 18 PY 2013 VL 102 IS 11 AR 111108 DI 10.1063/1.4796181 PG 4 WC Physics, Applied SC Physics GA 111TX UT WOS:000316544900008 ER PT J AU Sherwin, J Gaston, J AF Sherwin, Jason Gaston, Jeremy TI Soldiers and marksmen under fire: monitoring performance with neural correlates of small arms fire localization SO FRONTIERS IN HUMAN NEUROSCIENCE LA English DT Article DE EEG; auditory oddball; expertise; military medicine; military personnel; generalized linear models (GLMs); source localization ID INDEPENDENT COMPONENT ANALYSIS; IMPULSE NOISE; BRAIN; EEG; PERCEPTION; ALGORITHM; ODDBALL AB Important decisions in the heat of battle occur rapidly and a key aptitude of a good combat soldier is the ability to determine whether he is under fire. This rapid decision requires the soldier to make a judgment in a fraction of a second, based on a barrage of multisensory cues coming from multiple modalities. The present study uses an oddball paradigm to examine listener ability to differentiate shooter locations from audio recordings of small arms fire. More importantly, we address the neural correlates involved in this rapid decision process by employing single-trial analysis of electroencephalography (EEG). In particular, we examine small arms expert listeners as they differentiate the sounds of small arms firing events recorded at different observer position relative to a shooter. Using signal detection theory, we find clear neural signatures related to shooter firing angle by identifying the times of neural discrimination on a trial-to-trial basis. Similar to previous results in oddball experiments, we find common windows relative to the response and the stimulus when neural activity discriminates between target stimuli (forward fire: observer 0 degrees to firing angle) vs. standards(off-axis fire: observer 90 degrees tofiring angle).We also find, using windows of maximum discrimination, that auditory target vs. standard discrimination yields neural sources in Brodmann Area 19(BA19),i.e., in the visual cortex. In summary, we show that single-trial analysis of EEG yields informative scalp distributions and source current localization of discriminating activity when the small arms experts discriminate between forward and off-axis fire observer positions. Furthermore, this perceptual decision implicates brain regions involved in visual processing, even though the task is purely auditory. Finally, we utilize these techniques to quantify the level of expertise in these subjects for the chosen task, having implications for human performance monitoring in combat. C1 [Sherwin, Jason] Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA. [Sherwin, Jason; Gaston, Jeremy] USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA. RP Sherwin, J (reprint author), Columbia Univ, Dept Biomed Engn, 530 West 120th Street Mail Code 8904, New York, NY 10027 USA. EM jason.sherwin@columbia.edu FU Army Research Office [W911NF-11-1-0219]; US Army Research Laboratory Postdoctoral Fellowship Program FX This work was supported by a grant from the Army Research Office(W911NF-11-1-0219) and in part by an appointment to the US Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a contract with the US Army Research Laboratory. NR 33 TC 0 Z9 0 U1 1 U2 22 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1662-5161 J9 FRONT HUM NEUROSCI JI Front. Hum. Neurosci. PD MAR 18 PY 2013 VL 7 DI 10.3389/fnhum.2013.00067 PG 14 WC Neurosciences; Psychology SC Neurosciences & Neurology; Psychology GA 107XB UT WOS:000316253100001 ER PT J AU Breaud, AR Henemyre-Harris, CL Schools, S Emezienna, N Clarke, W AF Breaud, Autumn R. Henemyre-Harris, Claudia L. Schools, Sabitha Emezienna, Nkechinyere Clarke, William TI Rapid quantification of the aminoglycoside arbekacin in serum using high performance liquid chromatography-tandem mass spectrometry SO CLINICA CHIMICA ACTA LA English DT Article DE Arbekacin; Aminoglycosides; High performance liquid chromatography-tandem mass spectrometry ID RESISTANT STAPHYLOCOCCUS-AUREUS; RENAL ACCUMULATION; HUMAN PLASMA; HPLC-MS/MS; QUANTITATION; IMPACT; MRSA AB Background: This project entails the development and validation of a method for quantification of the aminoglycoside antibiotic arbekacin in serum using liquid chromatography tandem mass spectrometry (LC-MS/MS) for therapeutic drug monitoring in future clinical trials. Methods: Following a protein precipitation with 03 mol/l perchloric add containing internal standard dibekacin at a concentration of 0.6 mu g/ml, human serum samples containing arbekacin were analyzed using a Hypersil Gold PIP column and a liquid chromatography system. Elution occurred with a gradient of water and acetonitrile, each containing 0.05% (v/v) trifluoroacetic acid and 0.1% (v/v) formic acid. Analytes were detected over a 325 minute run time using a tandem mass spectrometer with a heated electrospray-ionization (HESI) source in positive ionization mode with selected reaction monitoring (SRM). Matrix effects, carryover, linearity, recovery, precision, and limit of quantification were carefully evaluated. Results: The limit of quantification for arbekacin was 0.1 mu g/ml. All simple and total precision CV's were less than 62%. The method was linear from 0.1 mu g/ml to 45.9 mu g/ml (slope of 0.973). The mean recovery ranged from 94.7 to 103.8%. No matrix effects were detected. Conclusions: This developed and validated LC-MS/MS method allows for the quantification of arbekacin in serum following protein precipitation. (C) 2013 Elsevier B.V. All rights reserved. C1 [Breaud, Autumn R.; Henemyre-Harris, Claudia L.; Schools, Sabitha; Emezienna, Nkechinyere; Clarke, William] Johns Hopkins Sch Med, Dept Pathol, Baltimore, MD USA. [Henemyre-Harris, Claudia L.] USA, Med Dept Ctr & Sch, Ft Sam Houston, TX USA. RP Clarke, W (reprint author), 1800 Orleans St,Zayed Tower B1020F, Baltimore, MD 21287 USA. EM wclarke@jhmi.edu FU USA MED Research ACQ Activity [W81XWH-11-C-0025] FX We thank Meiji Seika Kaisha, Ltd. for providing the arbekacin powder. We also thank Christa Madock and Jennifer Secula from the U.S. Army Medical Materiel Development Activity for providing several of the reference documents. This project was funded by USA MED Research ACQ Activity contract W81XWH-11-C-0025. NR 31 TC 4 Z9 4 U1 4 U2 33 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-8981 J9 CLIN CHIM ACTA JI Clin. Chim. Acta PD MAR 15 PY 2013 VL 418 BP 102 EP 106 DI 10.1016/j.cca.2013.01.004 PG 5 WC Medical Laboratory Technology SC Medical Laboratory Technology GA 111OL UT WOS:000316530500020 PM 23333924 ER PT J AU Bashir, IM Otsyula, N Awinda, G Spring, M Schneider, P Waitumbi, JN AF Bashir, Ismail Mahat Otsyula, Nekoye Awinda, George Spring, Michele Schneider, Petra Waitumbi, John Njenga TI Comparison of PfHRP-2/pLDH ELISA, qPCR and Microscopy for the Detection of Plasmodium Events and Prediction of Sick Visits during a Malaria Vaccine Study SO PLOS ONE LA English DT Article ID HISTIDINE-RICH PROTEIN-2; POLYMERASE-CHAIN-REACTION; RAPID DIAGNOSTIC-TESTS; TIME PCR ASSAY; PREGNANT-WOMEN; LACTATE-DEHYDROGENASE; ANTIGEN-DETECTION; PLACENTAL MALARIA; PARASITE DENSITY; FALCIPARUM AB Background: Compared to expert malaria microscopy, malaria biomarkers such as Plasmodium falciparum histidine rich protein-2 (PfHRP-2), and PCR provide superior analytical sensitivity and specificity for quantifying malaria parasites infections. This study reports on parasite prevalence, sick visits parasite density and species composition by different diagnostic methods during a phase-I malaria vaccine trial. Methods: Blood samples for microscopy, PfHRP-2 and Plasmodium lactate dehydrogenase (pLDH) ELISAs and real time quantitative PCR (qPCR) were collected during scheduled (n = 298) or sick visits (n = 38) from 30 adults participating in a 112-day vaccine trial. The four methods were used to assess parasite prevalence, as well as parasite density over a 42-day period for patients with clinical episodes. Results: During scheduled visits, qPCR (39.9%, N = 119) and PfHRP-2 ELISA (36.9%, N = 110) detected higher parasite prevalence than pLDH ELISA (16.8%, N = 50) and all methods were more sensitive than microscopy (13.4%, N = 40). All microscopically detected infections contained P. falciparum, as mono-infections (95%) or with P. malariae (5%). By qPCR, 102/119 infections were speciated. P. falciparum predominated either as monoinfections (71.6%), with P. malariae (8.8%), P. ovale (4.9%) or both (3.9%). P. malariae (6.9%) and P. ovale (1.0%) also occurred as co-infections (2.9%). As expected, higher prevalences were detected during sick visits, with prevalences of 65.8% (qPCR), 60.5% (PfHRP-2 ELISA), 21.1% (pLDH ELISA) and 31.6% (microscopy). PfHRP-2 showed biomass build-up that climaxed (1813 +/- 3410 ng/mL SD) at clinical episodes. Conclusion: PfHRP-2 ELISA and qPCR may be needed for accurately quantifying the malaria parasite burden. In addition, qPCR improves parasite speciation, whilst PfHRP-2 ELISA is a potential predictor for clinical disease caused by P. falciparum. C1 [Bashir, Ismail Mahat; Otsyula, Nekoye; Awinda, George; Waitumbi, John Njenga] Kenya Govt Med Res Ctr, Walter Reed Project, Kisumu, Kenya. [Bashir, Ismail Mahat; Spring, Michele] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. [Schneider, Petra] Univ Edinburgh, Inst Evolut, Edinburgh, Midlothian, Scotland. [Schneider, Petra] Univ Edinburgh, Inst Immunol, Edinburgh, Midlothian, Scotland. [Schneider, Petra] Univ Edinburgh, Inst Infect Res, Edinburgh, Midlothian, Scotland. RP Waitumbi, JN (reprint author), Kenya Govt Med Res Ctr, Walter Reed Project, Kisumu, Kenya. EM john.waitumbi@usamru-k.org OI Schneider, Petra/0000-0002-2616-237X FU US Agency for International Development (USAID); GlaxoSmithKline Biologicals (GSK); US Army Medical and Materiel Research Command (USAMRMC); Office of the Surgeon General, US Army FX The Study Sponsor was the Office of the Surgeon General, US Army. This study was funded by the US Agency for International Development (USAID), with partial support from GlaxoSmithKline Biologicals (GSK) and the US Army Medical and Materiel Research Command (USAMRMC). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 45 TC 6 Z9 6 U1 0 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 15 PY 2013 VL 8 IS 3 AR e56828 DI 10.1371/journal.pone.0056828 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 109ZC UT WOS:000316409800004 PM 23554856 ER PT J AU Michael, NL AF Michael, Nelson L. TI Cooling Off the Host Immune Response to Acute Simian Immunodeficiency Virus Infection-Is Less More? SO JOURNAL OF INFECTIOUS DISEASES LA English DT Editorial Material DE tumor necrosis factor-alpha; Simian immunodefiency virus infection; HIV/AIDS ID HIV-INFECTION; T-CELLS; HOMEOSTASIS; FIBROSIS C1 US Mil HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Michael, NL (reprint author), US Mil HIV Res Program, Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM nmichael@hivresearch.org NR 9 TC 0 Z9 0 U1 0 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD MAR 15 PY 2013 VL 207 IS 6 BP 875 EP 876 DI 10.1093/infdis/jis648 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 092XO UT WOS:000315156500001 PM 23100566 ER PT J AU Hosur, M Barua, R Zainuddin, S Kumar, A Trovillion, J Jeelani, S AF Hosur, Mahesh Barua, Rajib Zainuddin, Shaik Kumar, Ashok Trovillion, Jonathan Jeelani, Shaik TI Effect of processing techniques on the performance of Epoxy/MWCNT nanocomposites SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article DE nanocomposites; multiwalled carbon nanotubes; rheology; thermal properties; flexure ID NANOTUBE-REINFORCED EPOXY; WALL CARBON NANOTUBES; MECHANICAL-PROPERTIES; ELECTRICAL-PROPERTIES; DISPERSION PROCESS; COMPO SITES; POLYMER; MATRIX; FABRICATION; PURIFICATION AB The aim of this study is to investigate the optimum technique to disperse Multi-Walled Carbon Nanotubes (MWCNTs) in SC-1 epoxy uniformly and to evaluate the effect of processing technique on the performance of SC-1 epoxy. To achieve better dispersion, MWCNT was mixed with SC-1 resin directly or premixed with a solvent and then mixed with SC-1 resin after evaporating the solvent using sonication, thinky mixing and three-roll mill methods either in isolation or combination. Flexural tests were performed to evaluate mechanical performances and results exhibit up to 27.13, 13.51, and 21.99% improvement on flexural strength, flexural modulus, and maximum strain, respectively, over neat epoxy with only 0.2 wt % loading. Dynamic mechanical analysis (DMA), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) indicated improvement in storage modulus, Tg, inflection temperature, and residue content, respectively over neat SC-1 epoxy. Thermal and mechanical properties at higher loading conditions were seen to either reduce or not significantly improve. This was attributed to high viscosity of nanocomposites as determined by rheological analysis which prevents good dispersion of MWNCTs into epoxy system at 0.4 wt % loading. (c) 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013 C1 [Hosur, Mahesh; Zainuddin, Shaik; Jeelani, Shaik] Tuskegee Univ, Mat Sci & Engn Dept, Tuskegee, AL 36088 USA. [Barua, Rajib; Jeelani, Shaik] Tuskegee Univ, Dept Mech Engn, Tuskegee, AL 36088 USA. [Kumar, Ashok; Trovillion, Jonathan] USA, Construct Engn Res Lab, Champaign, IL 61821 USA. RP Hosur, M (reprint author), Tuskegee Univ, Mat Sci & Engn Dept, Tuskegee, AL 36088 USA. EM hosur@mytu.tuskegee.edu FU US Army Construction Engineering Research Laboratory [W9132-09-C-0010]; National Science Foundation EPSCoR [1158862]; National Science Foundation PREM [0611612] FX Authors acknowledge the support received by US Army Construction Engineering Research Laboratory through contract # W9132-09-C-0010, and National Science Foundation EPSCoR Grant # 1158862 and PREM Grant # 0611612. NR 34 TC 11 Z9 11 U1 0 U2 63 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0021-8995 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD MAR 15 PY 2013 VL 127 IS 6 BP 4211 EP 4224 DI 10.1002/app.37990 PG 14 WC Polymer Science SC Polymer Science GA 062RW UT WOS:000312940400003 ER PT J AU Stark, JK Ding, Y Kohl, PA AF Stark, Johanna K. Ding, Yi Kohl, Paul A. TI Role of Dissolved Gas in Ionic Liquid Electrolytes for Secondary Lithium Metal Batteries SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID ELECTROCHEMICAL PROPERTIES; CONTAMINATED SOLUTIONS; GRAPHITE ANODES; CARBON-DIOXIDE; SURFACE-FILMS; LI BATTERIES; SOLUBILITIES; ABSORPTION; INTERFACE; ALLOY AB Lithium metal is a potential anode in lithium batteries; however, high cycling efficiency has not been achieved. The effect of dissolved gas on the reversibility of a Li/Li+ electrode in an ionic liquid electrolyte was investigated. The ionic liquid electrolyte was saturated with argon, nitrogen, oxygen, air, or carbon dioxide, and the Coulombic efficiency for the reduction and reoxidation of lithium metal was measured. Secondary ion mass spectroscopy (SIMS) was used to determine the thickness and composition of the solid electrolyte interphase (SEI) layer formed on the lithium metal. The Coulombic cycling efficiency was highest with oxygen, nitrogen, and air. The Coulombic efficiency was significantly lower with dissolved carbon dioxide. SIMS revealed that the SEI layer was made up of primarily LiF regardless of the gas used. The thickness of the SEI layer was the main determinant of cycling efficiency. A thinner SEI, observed with nitrogen and oxygen, lead to the highest Coulombic efficiency, whereas carbon dioxide produced a thick SEI that appeared to inhibit lithium deposition. C1 [Stark, Johanna K.; Kohl, Paul A.] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA. [Ding, Yi] USA, RDECOM TARDEC, AMSRD TAR R, Warran, MI 48397 USA. RP Kohl, PA (reprint author), Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA. EM paul.kohl@chbe.gatech.edu FU US Army [US001-0000245070] FX We gratefully acknowledge the financial support of the US Army, contract US001-0000245070. NR 31 TC 5 Z9 5 U1 4 U2 89 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD MAR 14 PY 2013 VL 117 IS 10 BP 4980 EP 4985 DI 10.1021/jp4001303 PG 6 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 108PR UT WOS:000316308400012 ER PT J AU Asplund, CA Best, TM AF Asplund, Chad A. Best, Thomas M. TI Achilles tendon disorders SO BMJ-BRITISH MEDICAL JOURNAL LA English DT Review ID SHOCK-WAVE TREATMENT; NONOPERATIVE TREATMENT; FOLLOW-UP; ECCENTRIC EXERCISE; RANDOMIZED-TRIAL; TENDINOPATHY; RUPTURE; INJURY; RISK; INDIVIDUALS C1 [Asplund, Chad A.] Eisenhower Army Med Ctr, Dept Family Med, Ft Gordon, GA 30905 USA. [Best, Thomas M.] Ohio State Univ, Dept Family Med, Div Sports Med, Columbus, OH 43221 USA. RP Asplund, CA (reprint author), Eisenhower Army Med Ctr, Dept Family Med, Ft Gordon, GA 30905 USA. EM chad.asplund@gmail.com NR 66 TC 9 Z9 9 U1 1 U2 22 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1756-1833 J9 BMJ-BRIT MED J JI BMJ-British Medical Journal PD MAR 12 PY 2013 VL 346 AR f1262 DI 10.1136/bmj.f1262 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 108VM UT WOS:000316324300006 PM 23482943 ER PT J AU Jhamnani, S Lassance-Soares, R Sood, S Aghili, N Nashin, H Hammamieh, R Chakraborty, N Burnett, MS Epstein, S AF Jhamnani, Sunny Lassance-Soares, Roberta Sood, Subeena Aghili, Nima Nashin, Hajra Hammamieh, Rasha Chakraborty, Nabarun Burnett, Mary Susan Epstein, Stephen TI CHRONIC STRESS ACCELERATES AGING INDUCED COLLATERAL DYSFUNCTION IN C57BL6 MOUSE MODEL OF HIND LIMB ISCHEMIA SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Meeting Abstract CT 62nd Annual Scientific Session of the American-College-of-Cardiology CY MAR 09-11, 2013 CL San Francisco, CA SP Amer Coll Cardiol C1 MedStar Hlth Res Inst, Cardiovasc Res Inst, Washington, DC USA. USA, Ctr Environm Hlth Res, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD MAR 12 PY 2013 VL 61 IS 10 SU S BP E2090 EP E2090 PG 1 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 111XO UT WOS:000316555202294 ER PT J AU Bandyopadhyay, S Anderson, J AF Bandyopadhyay, Saumil Anderson, John TI Capacitive infrared photodetector for room temperature operation SO APPLIED PHYSICS LETTERS LA English DT Article ID QUANTUM-DOT; PHOTOCAPACITANCE AB We report a self-assembled semiconductor nanowire photodetector that detects infrared light at room temperature by registering a change in capacitance upon illumination. Its light-to-dark capacitance ratio exceeds 2.5 at a signal frequency of 75 kHz and gradually decays to 1 beyond 200 kHz. This detector also exhibits "frequency-selectivity" since it is more responsive to photons with energies close to the nanowire's effective bandgap than to higher energy photons. Such a light-sensitive capacitor, unlike a light-sensitive resistor, can be used in a resonant parallel inductor-capacitor circuit to yield giant light-to-dark contrast ratio even when the light-to-dark capacitance ratio is relatively small. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4795520] C1 [Bandyopadhyay, Saumil] Maggie L Walker Governors Sch Govt & Int Studies, Richmond, VA 23220 USA. [Bandyopadhyay, Saumil; Anderson, John] USA, Engineer Res & Dev Ctr, Alexandria, VA 22315 USA. RP Bandyopadhyay, S (reprint author), Maggie L Walker Governors Sch Govt & Int Studies, Richmond, VA 23220 USA. EM saumilb01@gmail.com NR 18 TC 8 Z9 8 U1 2 U2 27 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 11 PY 2013 VL 102 IS 10 AR 103108 DI 10.1063/1.4795520 PG 4 WC Physics, Applied SC Physics GA 111EG UT WOS:000316501200071 ER PT J AU Nayfeh, OM Birdwell, AG Tan, C Dubey, M Gullapalli, H Liu, Z Reddy, ALM Ajayan, PM AF Nayfeh, Osama M. Birdwell, A. Glen Tan, Cheng Dubey, Madan Gullapalli, Hemtej Liu, Zheng Reddy, Arava Leela Mohana Ajayan, Pulickel M. TI Increased mobility for layer-by-layer transferred chemical vapor deposited graphene/boron-nitride thin films SO APPLIED PHYSICS LETTERS LA English DT Article ID BORON-NITRIDE; HIGH-QUALITY; SCATTERING; TRANSPORT AB Large-area chemical vapor deposited graphene/boron-nitride (G/BN) thin films are co-transferred layer-by-layer to silicon-di-Oxide (SiO2) substrates, and transistors are constructed and examined. Raman spectra and high resolution transmission electron microscopy imaging show films of high quality. The graphene/boron-nitride/SiO2 devices have a significantly increased peak electron/hole mobility of 3400/2200 cm(2)/Vs with a reduced effective doping density over reference graphene/SiO2 devices. The mobility dependence as a function of carrier density is compared with a physically based empirical model and is in agreement with the improvements due to a consistent reduction in the substrate induced phonon and impurity scattering and an improvement in the overall surface quality owed to the boron-nitride interlayer that separates the graphene from the SiO2. Large-area G/BN thin films are promising for future high performance thin film electronic devices. [http://dx.doi.org/10.1063/1.4794533] C1 [Nayfeh, Osama M.; Birdwell, A. Glen; Tan, Cheng; Dubey, Madan] USA, Res Lab ARL, SEDD, Adelphi, MD 20783 USA. [Gullapalli, Hemtej; Liu, Zheng; Reddy, Arava Leela Mohana; Ajayan, Pulickel M.] Rice Univ, Dept Mech Engn & Mat Sci, Houston, TX 77005 USA. RP Dubey, M (reprint author), USA, Res Lab ARL, SEDD, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM madan.dubey@us.army.mil; ajayan@rice.edu RI Liu, Zheng/C-1813-2014; Arava, Leela Mohana Reddy/J-3180-2015; Gullapalli, Hemtej/P-7247-2014 OI Liu, Zheng/0000-0002-8825-7198; Gullapalli, Hemtej/0000-0003-1520-4287 FU Army Research Lab (ARL) Director's Strategic Initiative (DSI) program on graphene nanoelectronics; ONR MURI program on graphene FX The authors acknowledge the support of the Army Research Lab (ARL) Director's Strategic Initiative (DSI) program on graphene nanoelectronics. Device processing/characterization and Raman measurement was performed using the ARL device fabrication and nano-electronics laboratories. P. M. A. and Z.L. also acknowledge funding support from the ONR MURI program on graphene. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the ARLor the U. S. Government. The U.S. Government is authorized to reproduce or distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 15 TC 12 Z9 12 U1 3 U2 98 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 11 PY 2013 VL 102 IS 10 AR 103115 DI 10.1063/1.4794533 PG 3 WC Physics, Applied SC Physics GA 111EG UT WOS:000316501200078 ER PT J AU Yu, KM Sarney, WL Novikov, SV Detert, D Zhao, R Denlinger, JD Svensson, SP Dubon, OD Walukiewicz, W Foxon, CT AF Yu, K. M. Sarney, W. L. Novikov, S. V. Detert, D. Zhao, R. Denlinger, J. D. Svensson, S. P. Dubon, O. D. Walukiewicz, W. Foxon, C. T. TI Highly mismatched N-rich GaN1-xSbx films grown by low temperature molecular beam epitaxy SO APPLIED PHYSICS LETTERS LA English DT Article ID ALLOYS; BAND AB We have grown N-rich, dilute Sb GaN1-xSbx alloys by low temperature molecular beam epitaxy. At low growth temperature of <100 degrees C the material loses crystallinity and becomes primarily amorphous with small crystallites of 2-5 nm at a Sb composition of >4 at.%. Despite the different microstructures found for GaN1-xSbx alloys with different composition, the absorption edge shifts continuously from 3.4 eV (GaN) to close to 1 eV for samples with Sb content >30 at. %. GaN1-xSbx alloys with less than 5 at.% Sb show sufficient bandgap reduction (similar to 2 eV), making them suitable for photoelectrochemical applications. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4795446] C1 [Yu, K. M.; Detert, D.; Zhao, R.; Dubon, O. D.; Walukiewicz, W.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA. [Sarney, W. L.; Svensson, S. P.; Dubon, O. D.] USA, Res Lab, Adelphi, MD 20783 USA. [Novikov, S. V.; Foxon, C. T.] Univ Nottingham, Sch Phys & Astron, Nottingham NG7 2RD, England. [Detert, D.; Zhao, R.] Univ Calif Berkeley, Dept Mat Sci & Engn, Berkeley, CA 94720 USA. [Denlinger, J. D.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Adv Light Source, Berkeley, CA 94720 USA. RP Yu, KM (reprint author), Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Mat Sci, 1 Cyclotron Rd, Berkeley, CA 94720 USA. RI Yu, Kin Man/J-1399-2012 OI Yu, Kin Man/0000-0003-1350-9642 FU US Army [W911NF-12-2-0003]; Office of Science, Office of Basic Energy Sciences, Materials Sciences and Engineering Division, of the U.S. Department of Energy [DE-AC02-05CH11231] FX The MBE growth at the University of Nottingham was undertaken with support from the EPSRC and by the US Army under Cooperative Agreement No. W911NF-12-2-0003. RBS and optical measuremnts performed at LBNL were supported by the Director, Office of Science, Office of Basic Energy Sciences, Materials Sciences and Engineering Division, of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. NR 12 TC 12 Z9 12 U1 0 U2 12 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 11 PY 2013 VL 102 IS 10 AR 102104 DI 10.1063/1.4795446 PG 4 WC Physics, Applied SC Physics GA 111EG UT WOS:000316501200031 ER PT J AU Lemasson, BH Anderson, JJ Goodwin, RA AF Lemasson, B. H. Anderson, J. J. Goodwin, R. A. TI Motion-guided attention promotes adaptive communications during social navigation SO PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES LA English DT Article DE collective behaviour; vision; topological; selective attention; social information; speed-accuracy trade-offs ID ANIMAL GROUPS; FISH SCHOOLS; BEHAVIOR; FLOCKS; INFORMATION; ENVIRONMENT; PERCEPTION; DECISIONS; QUANTITY; DYNAMICS AB Animals are capable of enhanced decision making through cooperation, whereby accurate decisions can occur quickly through decentralized consensus. These interactions often depend upon reliable social cues, which can result in highly coordinated activities in uncertain environments. Yet information within a crowd may be lost in translation, generating confusion and enhancing individual risk. As quantitative data detailing animal social interactions accumulate, the mechanisms enabling individuals to rapidly and accurately process competing social cues remain unresolved. Here, we model how motion-guided attention influences the exchange of visual information during social navigation. We also compare the performance of this mechanism to the hypothesis that robust social coordination requires individuals to numerically limit their attention to a set of n-nearest neighbours. While we find that such numerically limited attention does not generate robust social navigation across ecological contexts, several notable qualities arise from selective attention to motion cues. First, individuals can instantly become a local information hub when startled into action, without requiring changes in neighbour attention level. Second, individuals can circumvent speed-accuracy trade-offs by tuning their motion thresholds. In turn, these properties enable groups to collectively dampen or amplify social information. Lastly, the minority required to sway a group's short-term directional decisions can change substantially with social context. Our findings suggest that motion-guided attention is a fundamental and efficient mechanism underlying collaborative decision making during social navigation. C1 [Lemasson, B. H.] USA, Environm Lab, Engineer Res & Dev Ctr, Portland, OR 97208 USA. [Anderson, J. J.; Goodwin, R. A.] Univ Washington, Sch Aquat & Fishery Sci, Seattle, WA 98195 USA. RP Lemasson, BH (reprint author), USA, Environm Lab, Engineer Res & Dev Ctr, Portland, OR 97208 USA. EM brilraven@gmail.com FU US Army's Network Science research initiative through the US Army Engineer Research & Development Center's Environmental Quality and Installations Basic Research Program FX The authors would like to thank Colby Tanner, Eric Dimperio and Mary Hunsicker for discussions and constructive comments. We also thank two anonymous referees for their insightful feedback. Jim Johnson, US Fish and Wildlife Service-Migratory Bird Management, and Bob Christensen provided access to the Chiloe Island Shorebird Conservation Program, which inspired this work. This research was sponsored by the US Army's Network Science research initiative through the US Army Engineer Research & Development Center's Environmental Quality and Installations Basic Research Program. Permission was granted by the Chief of Engineers to publish this information. NR 44 TC 8 Z9 9 U1 1 U2 51 PU ROYAL SOC PI LONDON PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND SN 0962-8452 J9 P ROY SOC B-BIOL SCI JI Proc. R. Soc. B-Biol. Sci. PD MAR 7 PY 2013 VL 280 IS 1754 AR 20122003 DI 10.1098/rspb.2012.2003 PG 9 WC Biology; Ecology; Evolutionary Biology SC Life Sciences & Biomedicine - Other Topics; Environmental Sciences & Ecology; Evolutionary Biology GA 072IN UT WOS:000313663700001 PM 23325772 ER PT J AU Bell, JC Wolf, EJ Schnall, BL Tis, JE Tis, LL Potter, MAJBK AF Bell, Johanna C. Wolf, Erik J. Schnall, Barri L. Tis, John E. Tis, Laurie L. Potter, M. A. J. Benjamin K. TI Transfemoral Amputations: The Effect of Residual Limb Length and Orientation on Gait Analysis Outcome Measures SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Article ID ABOVE-KNEE AMPUTATION; SWING-PHASE CONTROL; AMPUTEE GAIT; PROSTHETIC KNEES; WALKING SPEED; HIP MUSCLES; BIOMECHANICS AB Background: The level of function achieved following a transfemoral amputation is believed to be affected by surgical attachment of the remaining musculature, resulting orientation of the femur, residual limb length, and eventual prosthetic fit. Methods: Twenty-six subjects underwent gait analysis testing in the current preferred prosthesis more than twenty-four months postamputation. The femoral length and orientation angles of each subject were measured from standing postoperative radiographic scanograms. The subjects were separated into groups for analysis on the basis of the femoral shaft angles and the residual limb length ratios. Gait analysis was performed to collect kinematic and temporospatial parameters. Results: A good correlation was observed between residual femoral length and trunk with regard to forward lean (r = -0.683) and lateral flexion (r = -0.628). A good correlation was also observed between residual femoral length and pelvic motion with regard to pelvic tilt (r = -0.691) and obliquity (r = -0.398). A moderate correlation was observed with speed (r = 0.550), indicating that subjects with shorter residual limbs experienced a greater excursion in the torso and pelvis, while walking at a slower self-selected pace. A significant correlation (r = 0.721, p < 0.001) was observed between the femoral shaft abduction angle and the residual femoral length; the shorter the residual limb, the more abducted it was. Conclusions: The length of the residual femur substantially influences temporospatial and kinematic gait outcomes following transfemoral amputation, and appears to be more important than femoral orientation with regard to these parameters. C1 [Bell, Johanna C.; Wolf, Erik J.; Schnall, Barri L.; Tis, John E.; Tis, Laurie L.; Potter, M. A. J. Benjamin K.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Bell, JC (reprint author), Walter Reed Natl Mil Med Ctr, Ctr Performance & Clin Res, Amer Bldg 19,B-322,8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM Johanna.Bell@us.army.mil OI Wolf, Erik/0000-0002-6353-7978; Potter, MD, Benjamin K./0000-0002-8771-0317 NR 30 TC 8 Z9 8 U1 0 U2 12 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 USA SN 0021-9355 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD MAR 6 PY 2013 VL 95A IS 5 BP 408 EP 414 DI 10.2106/JBJS.K.01446 PG 7 WC Orthopedics; Surgery SC Orthopedics; Surgery GA AF8MV UT WOS:000334971200004 PM 23467863 ER PT J AU Wang, Y Mahle, JJ Furtado, AMB Glover, TG Buchanan, JH Peterson, GW Levan, MD AF Wang, Yu Mahle, John J. Furtado, Amanda M. B. Glover, T. Grant Buchanan, James H. Peterson, Gregory W. LeVan, M. Douglas TI Mass Transfer and Adsorption Equilibrium for Low Volatility Alkanes in BPL Activated Carbon SO LANGMUIR LA English DT Article ID SWING FREQUENCY-RESPONSE; BRANCHED HEXANE ISOMERS; MOLECULAR-DYNAMICS; NORMAL-PARAFFINS; VAPOR-PRESSURE; 5A ZEOLITE; N-DECANE; DIFFUSION; KINETICS; SEPARATION AB The structure of a molecule and its concentration can strongly influence diffusional properties for transport in nanoporous materials. We study mass transfer of alkanes in BPL activated carbon using the concentration-swing frequency response method, which can easily discriminate among mass transfer mechanisms. We measure concentration-dependent diffusion rates for n-hexane, n-octane, n-decane, 2,7-dimethyloctane, and cyclodecane, which have different carbon numbers and geometries: straight chain, branched chain, and cyclic. Micropore diffusion is determined to be the controlling mass transfer resistance except at low relative saturation for n-decane, where an external mass transfer resistance also becomes important, showing that the controlling mass transfer mechanism can change with system concentration. Micropore diffusion coefficients are found to be strongly concentration dependent. Adsorption isotherm slopes obtained from measured isotherms, the concentration-swing frequency response method, and a predictive method show reasonably good agreement. C1 [Wang, Yu; Furtado, Amanda M. B.; LeVan, M. Douglas] Vanderbilt Univ, Dept Chem & Biomol Engn, Nashville, TN 37235 USA. [Mahle, John J.; Buchanan, James H.; Peterson, Gregory W.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Glover, T. Grant] SAIC, Gunpowder, MD 21010 USA. RP Levan, MD (reprint author), Vanderbilt Univ, VU Stn B 351604, Nashville, TN 37235 USA. EM m.douglas.levan@vanderbilt.edu FU U.S. Army ECBC; Defense Threat Reduction Agency (DTRA) FX We are grateful to the U.S. Army ECBC and the Defense Threat Reduction Agency (DTRA) for the support of this research. NR 38 TC 5 Z9 5 U1 1 U2 34 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD MAR 5 PY 2013 VL 29 IS 9 BP 2935 EP 2945 DI 10.1021/la304926x PG 11 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 102KS UT WOS:000315844100017 PM 23360452 ER PT J AU Wei, M Boutwell, RC Garrett, GA Goodman, K Rotella, P Wraback, M Schoenfeld, WV AF Wei, M. Boutwell, R. C. Garrett, G. A. Goodman, K. Rotella, P. Wraback, M. Schoenfeld, W. V. TI Impact of oxygen source parameters on homoepitaxial ZnO films grown at low-temperature on Zn-polar substrates SO JOURNAL OF ALLOYS AND COMPOUNDS LA English DT Article DE ZnO; Molecular beam epitaxy; Homoepitaxy; Oxygen plasma; Atomic force microscopy ID MOLECULAR-BEAM EPITAXY; PLASMA; CRYSTAL AB ZnO thin films were epitaxially grown on Zn-polar (0001) ZnO substrates by plasma-assisted molecular beam epitaxy at a low temperature of 610 degrees C. The influence of Zn/O ratio on the epitaxial growth of ZnO was investigated. By optimizing the Zn/O ratio, a surface root mean square roughness of 0.277 nm with one or two monolayer height steps was achieved at a low growth temperature by growing on ZnO substrates with 0.5 degrees miscut angle toward the [1 (1) over bar 00] axis. Electrostatic ion trapping of the oxygen plasma was found crucial to deflect etching oxygen species at an oxygen flow rate of two standard cubic centimeters per minute, resulting in fewer surface defects and a longer photoluminescence (PL) lifetime of 217 ps. The impact of oxygen source gas purity was studied by high resolution X-ray diffraction and time-resolved photoluminescence (TRPL) measurements of resultant epilayers and higher gas purity was found necessary to reduce non-radiative centers. (C) 2012 Elsevier B. V. All rights reserved. C1 [Wei, M.; Boutwell, R. C.; Schoenfeld, W. V.] Univ Cent Florida, CREOL, Coll Opt & Photon, Orlando, FL 32816 USA. [Garrett, G. A.; Goodman, K.; Rotella, P.; Wraback, M.] USA, Res Lab, RDRL SEE M, Adelphi, MD 20783 USA. RP Schoenfeld, WV (reprint author), Univ Cent Florida, CREOL, Coll Opt & Photon, 4000 Cent Florida Blvd, Orlando, FL 32816 USA. EM winston@creol.ucf.edu OI Boutwell, Ryan/0000-0003-2321-1495 FU Army Research Laboratory [W911NF-11-2-0025] FX The authors would like to acknowledge financial support for this work by the Army Research Laboratory under Cooperative Agreement Number W911NF-11-2-0025. NR 24 TC 14 Z9 14 U1 1 U2 56 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0925-8388 J9 J ALLOY COMPD JI J. Alloy. Compd. PD MAR 5 PY 2013 VL 552 BP 127 EP 130 DI 10.1016/j.jallcom.2012.10.034 PG 4 WC Chemistry, Physical; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Chemistry; Materials Science; Metallurgy & Metallurgical Engineering GA 072EZ UT WOS:000313653300022 ER PT J AU Turalska, M West, BJ Grigolini, P AF Turalska, Malgorzata West, Bruce J. Grigolini, Paolo TI Role of committed minorities in times of crisis SO SCIENTIFIC REPORTS LA English DT Article ID ISING-MODEL; EQUILIBRIUM; SYSTEMS AB The surprising social phenomena of the Arab Spring and the Occupy Wall Street movement posit the question of whether the active role of committed groups may produce political changes of significant importance. Under what conditions are the convictions of a minority going to dominate the future direction of a society? We address this question with the help of a Cooperative Decision Making model (CDMM) which has been shown to generate consensus through a phase-transition process. We observe that in a system of a finite size the global consensus state is not permanent and times of crisis occur when there is an ambiguity concerning a given social issue. The correlation function within the cooperative system becomes similarly extended as it is observed at criticality. This combination of independence (free will) and long-range correlation makes it possible for very small but committed minorities to produce substantial changes in social consensus. C1 [Turalska, Malgorzata; West, Bruce J.] Duke Univ, Dept Phys, Durham, NC 27706 USA. [West, Bruce J.] USA, Informat Sci Directorate, Res Off, Durham, NC USA. [Grigolini, Paolo] Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA. RP Turalska, M (reprint author), Duke Univ, Dept Phys, Durham, NC 27706 USA. EM mat51@phy.duke.edu FU ARO [W911NF-11-1-0478] FX MT and PG gratefully acknowledge ARO for the financial support of this research through grant W911NF-11-1-0478. NR 26 TC 13 Z9 13 U1 0 U2 22 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD MAR 4 PY 2013 VL 3 AR 1371 DI 10.1038/srep01371 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 099CC UT WOS:000315595900001 PM 23455718 ER PT J AU Umphres, GD Roelke, DL Netherland, MD AF Umphres, George D. Roelke, Daniel L. Netherland, Michael D. TI The potential algaecide flumioxazin has little effect on growth, survival and feed conversion of the bluegill sunfish Lepomis macrochirus SO AQUACULTURE LA English DT Article DE Flumioxazin; Lepomis macrochirus; Prymnesium parvum; Fisheries management; Algae control ID ALGA PRYMNESIUM-PARVUM; PHOSPHORUS FERTILIZATION; FISH MORTALITY; BLOOM; TOXICITY; LAKE; PH; HAPTOPHYTA; SALINITY; DYNAMICS AB An effective and benign approach to mitigating fish-killing Prymnesium parvum blooms in small impoundments has yet to be identified. The aquatic herbicide flumioxazin (Clipper (R), Valent Corp., Walnut Creek, CA), however, shows promise as it suppresses P. parvum while having little effect on other plankton. Its influence on fish has yet to be evaluated. Here, we investigated potential effects of flumioxazin on growth, survival and feed conversion ratio of a non-target organism, bluegill sunfish (Lepomis macrochirus) in a laboratory experiment. We exposed fish to several herbicide concentrations that spanned the manufacturer's recommended dosage (0, 25, 50, 100, 200 and 400 mu g L-1). The duration of the experiment was six weeks with weekly re-application of flumioxazin to specified tanks. No significant differences were found in average fish weight gain (p=0.76), percent survival of fish (p=0.83) or the feed conversion ratio (p=0.89). These findings provide further evidence that flumioxazin application may be an effective and benign approach to P. parvum mitigation. (C) 2012 Elsevier B. V. All rights reserved. C1 [Umphres, George D.; Roelke, Daniel L.] Texas A&M Univ, Dept Wildlife & Fisheries Sci, College Stn, TX 77843 USA. [Roelke, Daniel L.] Texas A&M Univ, Dept Oceanog, College Stn, TX 77843 USA. [Netherland, Michael D.] USA, Erdc, Gainesville, FL 32653 USA. RP Roelke, DL (reprint author), Texas A&M Univ, Dept Oceanog, College Stn, TX 77843 USA. EM droelke@tamu.edu RI Roelke, Daniel/B-5766-2008 NR 33 TC 1 Z9 1 U1 0 U2 27 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0044-8486 J9 AQUACULTURE JI Aquaculture PD MAR 4 PY 2013 VL 380 BP 80 EP 83 DI 10.1016/j.aquaculture.2012.11.035 PG 4 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA 085VR UT WOS:000314642900013 ER PT J AU Hinton, L Hargrave, R Ahmed, I Jimenez, DE AF Hinton, Ladson Hargrave, Rita Ahmed, Iqbal Ike Jimenez, Daniel E. TI OVERVIEW AND USE OF DSM-5 CULTURAL FORMULATION IN OLDER ADULTS SO AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY LA English DT Meeting Abstract CT Annual Meeting of the American-Association-for-Geriatric-Psychiatry CY MAR 14-17, 2013 CL Los Angeles, CA SP Amer Assoc Geriatr Psychiat C1 [Hinton, Ladson; Hargrave, Rita] Univ Calif Davis, Sacramento, CA USA. [Jimenez, Daniel E.] Dartmouth, Hanover, NH USA. [Ahmed, Iqbal Ike] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Ahmed, Iqbal Ike] Univ Hawaii, Honolulu, HI 96822 USA. [Hargrave, Rita] VA No Calif Hlth Care Syst, Martinez, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1064-7481 EI 1545-7214 J9 AM J GERIAT PSYCHIAT JI Am. J. Geriatr. Psychiatr. PD MAR PY 2013 VL 21 IS 3 SU S BP S27 EP S27 PG 1 WC Geriatrics & Gerontology; Gerontology; Psychiatry SC Geriatrics & Gerontology; Psychiatry GA 298XQ UT WOS:000330358400035 ER PT J AU Risinger, JI Alkas, A Hood, BL Liu, BQ Challa, R Shoji, Y Wang, GS Chandramouli, GVR Fazleabas, A Ferguson, S Zahn, C Maxwell, GL Conrads, TP AF Risinger, John I. Alkas, Addie Hood, Brian L. Liu, Baoquan Challa, Rusheeswar Shoji, Yutaka Wang, Guisong Chandramouli, Gadisetti V. R. Fazleabas, Asgerally Ferguson, Susan Zahn, Christopher Maxwell, G. Larry Conrads, Thomas P. TI Unbiased Mass Spectrometry Based Identification of Proteins of the Uterine Epithelium and Stroma Discriminates between the Proliferative and Secretory Phases of the Menstrual Cycle SO REPRODUCTIVE SCIENCES LA English DT Meeting Abstract CT 60th Annual Scientific Meeting of the Society-for-Gynecologic-Investigation (SGI) CY MAR 20-23, 2013 CL Orlando, FL SP Soc Gynecol Invest C1 [Risinger, John I.; Liu, Baoquan; Challa, Rusheeswar; Shoji, Yutaka; Chandramouli, Gadisetti V. R.; Fazleabas, Asgerally; Ferguson, Susan] Michigan State Univ, Dept OB GYN & Reprod Biol, Grand Rapids, MI USA. [Alkas, Addie; Zahn, Christopher] Walter Reed Army Med Ctr, Dept OB GYN, Washington, DC 20307 USA. [Hood, Brian L.; Wang, Guisong; Maxwell, G. Larry; Conrads, Thomas P.] Inova Hlth Syst, Womens Hlth Integrated Res Ctr, Annandale, VA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1933-7191 EI 1933-7205 J9 REPROD SCI JI Reprod. Sci. PD MAR PY 2013 VL 20 IS S3 SU 3 BP 228A EP 228A PG 1 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 287LK UT WOS:000329543100560 ER PT J AU Farrell, KW AF Farrell, Kevin W. TI The Arc of War: Origins, Escalation, and Transformation SO JOURNAL OF WORLD HISTORY LA English DT Book Review C1 [Farrell, Kevin W.] US Mil Acad, West Point, NY 10996 USA. RP Farrell, KW (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU UNIV HAWAII PRESS PI HONOLULU PA 2840 KOLOWALU ST, HONOLULU, HI 96822 USA SN 1045-6007 EI 1527-8050 J9 J WORLD HIST JI J. World Hist. PD MAR PY 2013 VL 24 IS 1 BP 179 EP 181 PG 3 WC History SC History GA 284PQ UT WOS:000329332800007 ER PT J AU Sperry, JH Ward, MP Weatherhead, PJ AF Sperry, Jinelle H. Ward, Michael P. Weatherhead, Patrick J. TI Effects of Temperature, Moon Phase, and Prey on Nocturnal Activity in Ratsnakes: An Automated Telemetry Study SO JOURNAL OF HERPETOLOGY LA English DT Article ID DAILY ACTIVITY PATTERNS; ELAPHE OBSOLETA; BLACK RATSNAKES; SEASONAL ACTIVITY; PREDATION RISK; HABITAT USE; SNAKE; MOONLIGHT; ECOLOGY; AVAILABILITY AB Nocturnal activity is important for many animals, but difficulty in documenting that activity has hampered efforts to understand factors that influence when animals are active at night. We used automated radiotelemetry to provide the first detailed tests of the hypothesis that the nocturnal activity of free-ranging snakes should be influenced by temperature, moon phase, and prey abundance by using data for Ratsnakes (Pantherophis spp.) from Texas and Illinois. Ratsnakes exhibited some nocturnal behavior throughout their active season in both Texas and Illinois, although snakes were much more active at night in Texas than in Illinois. Texas snakes transitioned from primarily diurnal activity to primarily nocturnal activity over this snake's active season, whereas Illinois snakes were always most active in the middle of the day. For both populations, nocturnal activity was positively related to temperature but unrelated to moon phase. Ratsnakes in Texas exhibited a stepwise increase in nocturnal activity in mid-summer, independent of temperature and coincident with the shift in their diet to almost exclusively mammals active at night. Given the ability of snakes in both populations to be active at night when temperatures allow, warming climates could lead to an increase in nocturnal activity, with consequences for both the snakes and the species on which they prey. C1 [Sperry, Jinelle H.] Engineer Res & Dev Ctr, Champaign, IL 61826 USA. [Ward, Michael P.; Weatherhead, Patrick J.] Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA. RP Sperry, JH (reprint author), Engineer Res & Dev Ctr, POB 9005, Champaign, IL 61826 USA. EM jinelle.sperry@usace.army.mil FU U.S. Army; Army Corps of Engineers Engineer Research and Development Center FX For the Texas portion of this project we thank the U.S. Army and the Army Corps of Engineers Engineer Research and Development Center for funding, particularly J. Cornelius, T. Hayden, and T. Buchanan. We also thank C. Taylor and numerous other biologists for assistance in the field. For the Illinois portion we thank M. Alessi, H. Fraser, K. Sierzega, S. Chiavacci, T. Dallas, T. Beveroth, A. Raim, Vermilion County Conservation District, and the Illinois Department of Natural Resources for assistance in the field and access to the study area. We thank T. J. Benson for assistance with statistical analyses. NR 51 TC 13 Z9 13 U1 2 U2 34 PU SOC STUDY AMPHIBIANS REPTILES PI ST LOUIS PA C/O ROBERT D ALDRIDGE, ST LOUIS UNIV, DEPT BIOLOGY, 3507 LACLEDE, ST LOUIS, MO 63103 USA SN 0022-1511 EI 1937-2418 J9 J HERPETOL JI J. Herpetol. PD MAR PY 2013 VL 47 IS 1 BP 105 EP 111 DI 10.1670/11-325 PG 7 WC Zoology SC Zoology GA 264TG UT WOS:000327903300015 ER PT J AU Ponlawat, A Fansiri, T Kurusarttra, S Pongsiri, A McCardle, PW Evans, BP Richardson, JH AF Ponlawat, Alongkot Fansiri, Thanyalak Kurusarttra, Somwang Pongsiri, Arissara McCardle, Patrick W. Evans, Brain P. Richardson, Jason H. TI DEVELOPMENT AND EVALUATION OF A PYRIPROXYFEN-TREATED DEVICE TO CONTROL THE DENGUE VECTOR, AEDES AEGYPTI (L.) (DIPTERA:CULICIDAE) SO SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH LA English DT Article DE Aedes aegypti; pyriproxyfen; mosquito control; dengue; chikungunya ID LARVICIDE BACILLUS-SPHAERICUS; GROWTH-REGULATOR PYRIPROXYFEN; COMPARATIVE EFFICACY; LARVAL HABITATS; LETHAL OVITRAP; MOSQUITOS; EMBRYOGENESIS; SURVEILLANCE; OVIPOSITION; COLLECTION AB The resurgence of dengue fever and the chikungunya epidemic make the control of Aedes aegypti mosquitoes, the vectors of these diseases, critically important. We developed and evaluated an Ae. aegypti control device that is visually-attractive to mosquitoes. This pyriproxyfen-treated device was evaluated for its impact on Ae. aegypti egg production and population dynamics in dengue-endemic areas in Thailand. The device consists of a "high rise" shaped ovitrap/resting station covered with black cotton cloth. The device is easily collapsible and transportable. Ae. aegypti are generally drawn towards darker, shadier areas making this device physically attractive as a resting station to mosquitoes of all physiological stages. The results show this device suppressed Ae. aegypti populations after it was introduced into a village. The observed effect was primarily the result of the Ae. aegypti exposure to pyriproxyfen shortly after adult emergence or after taking a blood meal resulting in decreased egg production. We believe the device may be further improved physically and the formulation should be replaced to provide even better efficacy for controlling Ae. aegypti mosquito populations. C1 [Ponlawat, Alongkot; Fansiri, Thanyalak; Kurusarttra, Somwang; Pongsiri, Arissara; McCardle, Patrick W.; Evans, Brain P.; Richardson, Jason H.] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Richardson, Jason H.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD USA. RP Ponlawat, A (reprint author), Armed Forces Res Inst Med Sci, Dept Entomol, 315-6 Ratchawithi Rd, Bangkok 10400, Thailand. EM AlongkotP@afrims.org FU Deployed War-fighter Protection Research Program (DWFP) FX We acknowledge the excellent support of the entomology staff of the Vector Borne Disease Control Center (VBDC) 3.3 Rayong Province, especially Wanna P and Prawat C for assistance and data collection. We thank Somporn. C, Somsak T, Opas T, Prasan K, Chanyapat N, and Wachiraphan. C from Vector Biology and Control Section, Department of Entomology, USAMC-AFRIMS for the technical assistance. We would like to thank the health volunteers, and villagers from the study sites for allowing us to collect Ae. aegypti in their homes. We acknowledge Sumitomo Company, Thailand, for providing the pyriproxyfen used in the current study. We are grateful to Dr Michelle Helinski, Dr Lauren Cator and Harrington's laboratory members, Cornell University for the critical review of this manuscript. This work was funded by the Deployed War-fighter Protection Research Program (DWFP). NR 28 TC 4 Z9 5 U1 0 U2 5 PU SOUTHEAST ASIAN MINISTERS EDUC ORGANIZATION PI BANGKOK PA SEAMEO-TROPMED, 420-6 RAJVITHI RD,, BANGKOK 10400, THAILAND SN 0125-1562 J9 SE ASIAN J TROP MED JI Southeast Asian J. Trop. Med. Public Health PD MAR PY 2013 VL 44 IS 2 BP 167 EP 178 PG 12 WC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine SC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine GA 254NC UT WOS:000327171400005 PM 23691625 ER PT J AU Wichit, S Yongpradoem, H Surasombatpattana, P Leaungwuttiwong, P Kalambaheti, T Jampangern, W Jittmittraphap, A AF Wichit, Sineewanlaya Yongpradoem, Hatairat Surasombatpattana, Pornapat Leaungwuttiwong, Pornsawan Kalambaheti, Thareerat Jampangern, Wipawee Jittmittraphap, Akanitt TI CLONING AND APPLICATION OF RECOMBINANT DENGUE VIRUS M-PR-M PROTEIN FOR SERODIAGNOSIS OF DENGUE VIRUS INFECTION SO SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH LA English DT Article DE dengue virus; prM-M; recombinant protein; ELISA; Western blot ID EVOLUTION AB We studied the use of the precursor to the M structural protein (prM) found only on the surface of mature dengue virus as a target protein to detect dengue virus infection. Recombinant D2-16681 prM-M protein was constructed and tested for immunogenicity with dengue and Japanese encephalitis patient sera by Western blot analysis and indirect ELISA. The sensitivity and specificity of indirect ELISA were 48.1 and 85.5%, respectively, and Western blot assay were 23.1 and 98.7%, respectively, for detection of dengue virus. Although the sensitivity of the indirect ELISA is low, the indirect ELISA using recombinant D2-16681 prM-M proteins as antigen may be used for early detection of dengue virus infection. C1 [Wichit, Sineewanlaya; Yongpradoem, Hatairat; Surasombatpattana, Pornapat; Leaungwuttiwong, Pornsawan; Kalambaheti, Thareerat; Jampangern, Wipawee; Jittmittraphap, Akanitt] Mahidol Univ, Dept Microbiol & Immunol, Fac Trop Med, Bangkok 10400, Thailand. [Wichit, Sineewanlaya] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Jittmittraphap, A (reprint author), Mahidol Univ, Dept Microbiol & Immunol, Fac Trop Med, 420-6 Ratchawithi Rd, Bangkok 10400, Thailand. EM akanitt.jit@mahidol.ac.th FU Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Thailand FX This study was supported by the Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Thailand. We thank the Department of Virology, Armed Forces Research Institute of Medical Sciences (AFRIMS) for the serological diagnosis. We also would like to thank the public health inspector, director of the hospital and the staff in Nong Khai and Nakhon Phanom Provinces. NR 11 TC 0 Z9 0 U1 1 U2 3 PU SOUTHEAST ASIAN MINISTERS EDUC ORGANIZATION PI BANGKOK PA SEAMEO-TROPMED, 420-6 RAJVITHI RD,, BANGKOK 10400, THAILAND SN 0125-1562 J9 SE ASIAN J TROP MED JI Southeast Asian J. Trop. Med. Public Health PD MAR PY 2013 VL 44 IS 2 BP 218 EP 225 PG 8 WC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine SC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine GA 254NC UT WOS:000327171400011 PM 23691631 ER PT J AU Bodhidatta, L Srijan, A Serichantalergs, O Bangtrakulnonth, A Wongstitwilairung, B McDaniel, P Mason, CJ AF Bodhidatta, Ladaporn Srijan, Apichai Serichantalergs, Oralak Bangtrakulnonth, Aroon Wongstitwilairung, Boonchai McDaniel, Philip Mason, Carl J. TI BACTERIAL PATHOGENS ISOLATED FROM RAW MEAT AND POULTRY COMPARED WITH PATHOGENS ISOLATED FROM CHILDREN IN THE SAME AREA OF RURAL THAILAND SO SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH LA English DT Article DE Campylobacter; Salmonella; Arcobacter; diarrhea; food; Thailand ID CAMPYLOBACTER-JEJUNI; RESISTANT SALMONELLA; ARCOBACTER-BUTZLERI; FOODS; SEROVARS; HUMANS; IDENTIFICATION; CONTAMINATION; CONSEQUENCES; HELICOBACTER AB To better understand the epidemiology of bacterial food borne pathogens in children, in relation to pathogens in meats from a market in rural Thailand, we collected 73 cultures samples from raw chicken, pork and fish at a local market where diarrheal disease surveillance was conducted. Standard methods were employed to isolate, identify and serotype enteric pathogens from children and food samples. Antibiotic susceptibility testing was performed. Ninety-seven percent of food samples were contaminated with at least one enteric pathogen. The pathogens most commonly isolated from food were Salmonella spp (84%), Arcobacter butzleri (74%) and Campylobacter spp (51%). The most common serovars of Salmonella obtained from humans with diarrhea were S. Risen, S. Stanley and S. Anatum. Most common serovars of Salmonella isolated from food were S. Anatum, S. Stanley, and S. Corvallis. Fifty-one percent and 25% of children infected with Salmonella and Campylobacter, respectively, infected with the same serotypes isolated from food samples, suggesting these pathogens are widespread in food and humans. Pulsed-field gel analysis of Salmonella spp revealed 65 pulsotypes, but no point-sources of salmonellosis were identified. Joint epidemiologic/laboratory studies are useful to describe the epidemiology of enteric pathogens in rural populations. C1 [Bodhidatta, Ladaporn; Srijan, Apichai; Serichantalergs, Oralak; Wongstitwilairung, Boonchai; Mason, Carl J.] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand. [Bangtrakulnonth, Aroon] World Hlth Org WHO Natl Salmonella & Shigella Ctr, Bangkok, Thailand. [McDaniel, Philip] Kwai River Christian Hosp KRCH, Sangkhla Buri, Kanchanaburi, Thailand. RP Bodhidatta, L (reprint author), Armed Forces Res Inst Med Sci, Dept Enter Dis, 315-6 Ratchawithi Rd, Bangkok 10400, Thailand. EM ladapornb@afrims.org FU Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance and Response System (AFHSC-GEIS), Washington, DC, USA FX We are thankful to the staff of the Enteric Diseases Department, AFRIMS, Bangkok, for bacterial identification, collection and molecular typing. This work was supported by the Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance and Response System (AFHSC-GEIS), Washington, DC, USA. NR 37 TC 5 Z9 5 U1 0 U2 2 PU SOUTHEAST ASIAN MINISTERS EDUC ORGANIZATION PI BANGKOK PA SEAMEO-TROPMED, 420-6 RAJVITHI RD,, BANGKOK 10400, THAILAND SN 0125-1562 J9 SE ASIAN J TROP MED JI Southeast Asian J. Trop. Med. Public Health PD MAR PY 2013 VL 44 IS 2 BP 259 EP 272 PG 14 WC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine SC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine GA 254NC UT WOS:000327171400016 PM 23691636 ER PT J AU Stratman, KN Overholt, WA Cuda, JP Netherland, MD Wilson, PC AF Stratman, K. N. Overholt, W. A. Cuda, J. P. Netherland, M. D. Wilson, P. C. TI Host range and searching behaviour of Cricotopus lebetis (Diptera: Chironomidae), a tip miner of Hydrilla verticillata (Hydrocharitaceae) SO BIOCONTROL SCIENCE AND TECHNOLOGY LA English DT Article DE weed biological control; host finding; random search; aquatic olfactometer ID PHYTOPHAGOUS INSECTS; OVIPOSITION; PERFORMANCE; PREFERENCE AB A chironomid midge, Cricotopus lebetis Sublette (Diptera: Chironomidae), was discovered feeding on Hydrilla verticillata (L.f.) Royle (Hydrocharitaceae) in Crystal River, Citrus, Co., Florida, in the 1990s. Larvae of the midge mine the apical meristems of hydrilla, causing terminal branching and stunting of the plant. We investigated the fundamental host range of the midge by conducting a series of no-choice and paired-choice tests. No-choice developmental tests with neonate larvae revealed that the fundamental host range of C. lebetis included not only on hydrilla but also several other aquatic plants in different families, suggesting that this insect is not a hydrilla specialist. In paired-choice bioassays, larval colonisation of Elodea canadensis Michx. (Hydrocharitaceae) and Najas guadalupensis (Spreng.) Magnus (Najadaceae) was greater than colonisation of H. verticillata. Behavioural bioassays in a Y-tube olfactometer and in Petri dishes suggested that neonate larvae were not able to locate host plant material, whereas older larvae were successful in finding hosts. In paired-choice oviposition tests, adult females discriminated between potential oviposition sites, with greater numbers of eggs laid on E. canadensis and N. guadalupensis than on H. verticillata. This study is the first detailed account of host searching and oviposition behaviour of a phytophagous chironomid midge. The results will be used to assess the potential value of C. lebetis as a biological control agent of hydrilla. C1 [Stratman, K. N.; Overholt, W. A.; Wilson, P. C.] Univ Florida, Indian River Res & Educ Ctr, Ft Pierce, FL USA. [Cuda, J. P.] Univ Florida, Dept Entomol & Nematol, Gainesville, FL 32611 USA. [Netherland, M. D.] Ctr Aquat & Invas Plants, US Army Engn Res & Dev Ctr, Gainesville, FL USA. RP Overholt, WA (reprint author), Univ Florida, Indian River Res & Educ Ctr, Ft Pierce, FL USA. EM billover@ufl.edu FU USDA Hydrilla IPM RAMP grant; Florida Fish and Wildlife Conservation Commission FX We thank the USDA Hydrilla IPM RAMP grant and the Florida Fish and Wildlife Conservation Commission for providing financial support for this research. We also thank Dana Denson, Robert Rutter and Doug Strom for sharing their C. lebetis collection records and John Epler for assistance with the identification of chironomids. A special thanks to Niels Brouwers for help with fitting our data to the correlated random walk model. We also thank the staff at the Biological Control Research and Containment laboratory in Fort Pierce, Florida, for assistance with insect rearing and experiments. NR 33 TC 8 Z9 8 U1 0 U2 14 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0958-3157 EI 1360-0478 J9 BIOCONTROL SCI TECHN JI Biocontrol Sci. Technol. PD MAR 1 PY 2013 VL 23 IS 3 BP 317 EP 334 DI 10.1080/09583157.2012.757297 PG 18 WC Biotechnology & Applied Microbiology; Entomology SC Biotechnology & Applied Microbiology; Entomology GA 243XP UT WOS:000326352000006 ER PT J AU Grooms, DR Grindstaff, TL Croy, T Hart, JM Saliba, SA AF Grooms, Dustin R. Grindstaff, Terry L. Croy, Theodore Hart, Joseph M. Saliba, Susan A. TI Clinimetric Analysis of Pressure Biofeedback and Transversus Abdominis Function in Individuals With Stabilization Classification Low Back Pain SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE lumbar stabilization; sonography; trunk control ID DRAWING-IN MANEUVER; M-MODE ULTRASOUND; MUSCLE THICKNESS; INTRAABDOMINAL PRESSURE; ELECTROMYOGRAPHIC ACTIVITY; SURFACE ELECTROMYOGRAPHY; HOLLOWING EXERCISES; TRUNK MUSCLES; LUMBAR SPINE; CONTRACTION AB STUDY DESIGN: Descriptive laboratory study. OBJECTIVE: To determine if a proposed clinical test (pressure biofeedback) could detect changes in transversus abdominis (TrA) muscle thickness during an abdominal drawing-in maneuver. BACKGROUND: Pressure biofeedback may be used to assess abdominal muscle function and TrA activation during an abdominal drawing-in maneuver but has not been validated. METHODS: Forty-nine individuals (18 men, 31 women) with low back pain who met stabilization classification criteria underwent ultrasound imaging to quantify changes in TrA muscle thickness while a pressure transducer was used to measure pelvic and spine position during an abdominal drawing-in maneuver. A paired t test was used to compare differences in TrA activation ratios between groups (able or unable to maintain pressure of 40 5 mmHg). The groups were further dichotomized based on TrA activation ratio (high, greater than 1.5; low, less than 1.5). Sensitivity, specificity, and likelihood ratios were calculated. RESULTS: There was not a significant difference (P = .57) in TrA activation ratios (able to maintain pressure, 1.59 +/- 0.28; unable to maintain pressure, 1.54 +/- 0.24) between groups. The pressure biofeedback test had low sensitivity of 0.22 (95% confidence interval [CI]: 0.10, 0.42) but moderate specificity of 0.77 (95% CI: 0.58, 0.89), a positive likelihood ratio of 0.94(95% CI: 0.33, 2.68), and a negative likelihood ratio of 1.02(95% CI: 0.75, 1.38). CONCLUSION: Successful completion on pressure biofeedback does not indicate high TrA activation. Unsuccessful completion on pressure biofeedback may be more indicative of low TrA activation, but the correlation and likelihood coefficients indicate that the pressure test is likely of minimal value to detect TrA activation. C1 [Grooms, Dustin R.] Ohio State Univ, Sch Hlth & Rehabil Sci, Columbus, OH 43210 USA. [Grindstaff, Terry L.] Creighton Univ, Dept Phys Therapy, Omaha, NE 68178 USA. [Croy, Theodore] US Army Baylor Univ, US Army Med Specialist Corps, Doctoral Program Phys Therapy, Ft Sam Houston, TX USA. [Hart, Joseph M.; Saliba, Susan A.] Univ Virginia, Dept Human Serv, Kinesiol Program, Charlottesville, VA USA. RP Grooms, DR (reprint author), Ohio State Univ, Sch Hlth & Rehabil Sci, 453 West 10th Ave,228C Atwell Hall, Columbus, OH 43210 USA. EM Grooms.69@osu.edu OI Saliba, Susan/0000-0001-7179-8310; Hart, Joe/0000-0002-0410-5112 NR 71 TC 4 Z9 5 U1 0 U2 9 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD MAR PY 2013 VL 43 IS 3 BP 184 EP 193 DI 10.2519/jospt.2013.4397 PG 10 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 236FR UT WOS:000325781400010 PM 23160344 ER PT J AU Waksman, A Sethumadhavan, S Eum, J AF Waksman, Adam Sethumadhavan, Simha Eum, Julianna TI Practical, Lightweight Secure Inclusion of Third-Party Intellectual Property SO IEEE DESIGN & TEST LA English DT Article C1 [Waksman, Adam; Sethumadhavan, Simha] Columbia Univ, Comp Architecture & Secur Technol Lab, New York, NY 10027 USA. [Eum, Julianna] US Mil Acad, CRC, West Point, NY USA. RP Waksman, A (reprint author), Columbia Univ, Dept Comp Sci, Comp Architecture & Secur Technol Lab, New York, NY 10027 USA. EM waksman@cs.columbia.edu FU AFOSR [FA 99500910389]; DARPA [FA 865011C7190, FA 87501020253]; NSF [CCF/TC 1054844] FX This work was supported by Grants FA 99500910389 (AFOSR), FA 865011C7190 (DARPA), FA 87501020253 (DARPA), CCF/TC 1054844 (NSF), and gifts from Microsoft Research, WindRiver Corp, Xilinx, and Synopsys, Inc. Opinions, findings, conclusions, and recommendations expressed in this material are those of the authors and do not necessarily refect the views of the U.S. Government or commercial entities. NR 8 TC 4 Z9 4 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 2168-2356 J9 IEEE DES TEST JI IEEE Des. Test PD MAR-APR PY 2013 VL 30 IS 2 SI SI BP 8 EP 16 DI 10.1109/MDT.2013.2247458 PG 9 WC Computer Science, Hardware & Architecture; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 232MK UT WOS:000325497800003 ER PT J AU Karl, JP Young, AJ Rood, JC Montain, SJ AF Karl, J. Philip Young, Andrew J. Rood, Jennifer C. Montain, Scott J. TI Independent and Combined Effects of Eating Rate and Energy Density on Energy Intake, Appetite, and Gut Hormones SO OBESITY LA English DT Article ID GLUCAGON-LIKE PEPTIDE-1; FOOD-INTAKE; PANCREATIC-POLYPEPTIDE; PLASMA GHRELIN; OBESE SUBJECTS; WEIGHT STATUS; FAT-CONTENT; SATIETY; WOMEN; HUMANS AB Objective: Energy density (ED) and eating rate (ER) influence energy intake; their combined effects on intake and on postprandial pancreatic and gut hormone responses are undetermined. To determine the combined effects of ED and ER manipulation on voluntary food intake, subjective appetite, and postprandial pancreatic and gut hormone responses. Design and Methods: Twenty nonobese volunteers each consumed high (1.6 kcal g(-1); HED) and low (1.2 kcal g(-1); LED) ED breakfasts slowly (20 g min(-1); SR) and quickly (80 g min(-1); FR) ad libitum to satiation. Appetite, and pancreatic and gut hormone concentrations were measured periodically over 3 h. Ad libitum energy intake during the subsequent lunch was then measured. Results: Main effects of ED and ER on energy intake and a main effect of ER, but not ED, on mass of food consumed were observed, FR and HED being associated with increased intake (P < 0.05). Across all conditions, energy intake was highest during FR-HED (P <= 0.01). Area under the curve (AUC) of appetite ratings was not different between meals. Main effects of ED and ER on insulin, peptide-YY, and glucagon-like peptide-1 AUC (P < 0.05) were observed, FR and HED being associated with larger AUC. No effects on active or total ghrelin AUC were documented. Total energy intake over both meals was highest during the FR-HED trial with the greatest difference between FR-HED and SR-LED trials (P <= 0.01). Conclusion: Consuming an energy dense meal quickly compounds independent effects of ER and ED on energy intake. Energy compensation at the following meal may not occur despite altered gut hormone responses. C1 [Karl, J. Philip; Young, Andrew J.; Montain, Scott J.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA USA. [Rood, Jennifer C.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Clin Chem Core, Baton Rouge, LA USA. RP Karl, JP (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA USA. EM james.p.karl@us.army.mil OI Karl, J. Philip/0000-0002-5871-2241 FU US Army Medical Research and Materiel Command FX Funding agencies: This study is funded by the US Army Medical Research and Materiel Command. NR 40 TC 12 Z9 12 U1 6 U2 21 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1930-7381 EI 1930-739X J9 OBESITY JI Obesity PD MAR PY 2013 VL 21 IS 3 BP E244 EP E252 DI 10.1002/oby.20075 PG 9 WC Endocrinology & Metabolism; Nutrition & Dietetics SC Endocrinology & Metabolism; Nutrition & Dietetics GA 187AK UT WOS:000322087600010 PM 23592679 ER PT J AU Zander, NE AF Zander, Nicole E. TI Hierarchically Structured Electrospun Fibers SO POLYMERS LA English DT Review DE electrospinning; hierarchical; core-shell; helical; nanoporous; patterned; nanofiber ID UNIAXIALLY ALIGNED ARRAYS; ELECTRICALLY FORCED JETS; BLOCK-COPOLYMER FIBERS; POLYMER NANOFIBERS; CELLULAR INFILTRATION; CARBON NANOFIBERS; EXHIBITING SUPERHYDROPHOBICITY; COMPOSITE NANOFIBERS; COLLAGEN NANOFIBERS; CONJUGATED POLYMERS AB Traditional electrospun nanofibers have a myriad of applications ranging from scaffolds for tissue engineering to components of biosensors and energy harvesting devices. The generally smooth one-dimensional structure of the fibers has stood as a limitation to several interesting novel applications. Control of fiber diameter, porosity and collector geometry will be briefly discussed, as will more traditional methods for controlling fiber morphology and fiber mat architecture. The remainder of the review will focus on new techniques to prepare hierarchically structured fibers. Fibers with hierarchical primary structures-including helical, buckled, and beads-on-a-string fibers, as well as fibers with secondary structures, such as nanopores, nanopillars, nanorods, and internally structured fibers and their applications-will be discussed. These new materials with helical/buckled morphology are expected to possess unique optical and mechanical properties with possible applications for negative refractive index materials, highly stretchable/high-tensile-strength materials, and components in microelectromechanical devices. Core-shell type fibers enable a much wider variety of materials to be electrospun and are expected to be widely applied in the sensing, drug delivery/controlled release fields, and in the encapsulation of live cells for biological applications. Materials with a hierarchical secondary structure are expected to provide new superhydrophobic and self-cleaning materials. C1 US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Zander, NE (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM nicole.e.zander.civ@mail.mil NR 191 TC 23 Z9 23 U1 35 U2 377 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 2073-4360 J9 POLYMERS-BASEL JI Polymers PD MAR PY 2013 VL 5 IS 1 BP 19 EP 44 DI 10.3390/polym5010019 PG 26 WC Polymer Science SC Polymer Science GA 185DO UT WOS:000321945600002 ER PT J AU Suir, GM Evers, DE Steyer, GD Sasser, CE AF Suir, Glenn M. Evers, D. Elaine Steyer, Gregory D. Sasser, Charles E. TI Development of a Reproducible Method for Determining Quantity of Water and its Configuration in a Marsh Landscape SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE Landscape characterization; fragmentation metrics; landscape pattern analysis; wetlands; coastal Louisiana; geospatial technologies ID METRICS; SCALE; PATTERN AB Coastal Louisiana is a dynamic and ever-changing landscape. From 1956 to 2010, over 3,734 km(2) of Louisiana's coastal wetlands have been lost due to a combination of natural and human-induced activities. The resulting landscape constitutes a mosaic of conditions from highly deteriorated to relatively stable with intact landmasses. Understanding how and why coastal landscapes change over time is critical to restoration and rehabilitation efforts. Historically, changes in marsh pattern (i.e., size and spatial distribution of marsh landmasses and water bodies) have been distinguished using visual identification by individual researchers. Difficulties associated with this approach include subjective interpretation, uncertain reproducibility, and laborious techniques. In order to minimize these limitations, this study aims to expand existing tools and techniques via a computer-based method, which uses geospatial technologies for determining shifts in landscape patterns. Our method is based on a raster framework and uses landscape statistics to develop conditions and thresholds for a marsh classification scheme. The classification scheme incorporates land and water classified imagery and a two-part classification system: (1) ratio of water to land, and (2) configuration and connectivity of water within wetland landscapes to evaluate changes in marsh patterns. This analysis system can also be used to trace trajectories in landscape patterns through space and time. Overall, our method provides a more automated means of quantifying landscape patterns and may serve as a reliable landscape evaluation tool for future investigations of wetland ecosystem processes in the northern Gulf of Mexico. C1 [Suir, Glenn M.] Louisiana State Univ, US Army, Engineer Res & Dev Ctr, Baton Rouge, LA 70803 USA. [Evers, D. Elaine; Sasser, Charles E.] Louisiana State Univ, Sch Coast & Environm, Coastal Ecol Inst, Baton Rouge, LA 70803 USA. [Steyer, Gregory D.] Louisiana State Univ, US Geol Survey, Natl Wetlands Res Ctr, Livestock Show Off, Baton Rouge, LA 70894 USA. RP Suir, GM (reprint author), Louisiana State Univ, US Army, Engineer Res & Dev Ctr, 3253 Energy Coast & Environm Bldg, Baton Rouge, LA 70803 USA. EM Glenn.M.Suir@usace.army.mil FU U.S. Department of Interior, Bureau of Ocean Energy Management, Regulation and Enforcement, Gulf of Mexico Region, Gulf of Mexico Outer Continental Shelf Region FX This research was supported in part by the U.S. Department of Interior, Bureau of Ocean Energy Management, Regulation and Enforcement, Gulf of Mexico Region (Formerly Mineral Management Service, Gulf of Mexico Outer Continental Shelf Region) Gulf of Mexico Outer Continental Shelf Region. We are grateful to our colleagues Craig Conzelmann and William Sleavin for provision of data processing and transformation applications. Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. Government. NR 28 TC 2 Z9 2 U1 4 U2 12 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD SPR PY 2013 SI 63 BP 110 EP 117 DI 10.2112/SI63-010.1 PG 8 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA 173KE UT WOS:000321077600010 ER PT J AU Morang, A Rosati, JD King, DB AF Morang, Andrew Rosati, Julie D. King, David B. TI Regional Sediment Processes, Sediment Supply, and Their Impact on the Louisiana Coast SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE Mississippi River; Atchafalaya River; sediment budget; delta; distributary; barrier island; Balize Delta; dredging ID GULF-OF-MEXICO; MISSISSIPPI DELTA PLAIN; BARRIER-ISLAND ARC; RIVER DELTA; ISLES-DERNIERES; INNER SHELF; USA; RESTORATION; TRANSPORT; HURRICANES AB Coastal Louisiana is geologically unique in the United States because its complex shallow geologic structure is the result of fluvial deposition (Mississippi and Atchafalaya Rivers) and marine reworking over thousands of years. Other characteristics include the preponderance of fine sediment, relative youth, and shallow nearshore slope. It has been impacted by more than 150 years of project-focused designs that have modified regional sediment transport. Because of engineering and commercial activities on the upper Mississippi River and the delta, the system is now suffering from innumerable geomorphic changes, which have produced profound social and economic consequences. Sediment to this coast has been almost totally supplied by the Mississippi's distributaries, with deltaic lobes changing over the centuries. Sediment delivery has diminished by over 50% during the last 150 years because of up-river engineering activities such as dam construction, bank stabilization, dredging, and levees. The ultimate implication of reduced sediment and rapid relative sea-level rise is that the delta can no longer grow as it did before urbanization and development of the continent. A sediment budget has been developed for the Louisiana coast based on multiyear data preceding Hurricanes Katrina and Rita. The budget is based on numerous sources and dredging data from the U.S. Army Corps of Engineers, New Orleans District. Despite the typically low-wave energy climate, sediment is transported alongshore between some cells. Also, there is significant loss offshore, possibly a consequence of storm impacts, sediment consolidation, and rapid relative sea-level rise. C1 [Morang, Andrew; Rosati, Julie D.; King, David B.] US Army, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Morang, A (reprint author), US Army, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Andrew.Morang@usace.army.mil FU USACE, New Orleans District; LACPR Program; National Shoreline Management Study; RSM Program FX The authors thank Drs. Edmond Russo and Jeffrey Waters and two anonymous reviewers for insightful comments. Numerous personnel at USACE, New Orleans and Galveston Districts, generously supplied dredging, topographic, and other data. Mckenzie Pollock assisted with editorial reviewing. This work was funded by USACE, New Orleans District, the LACPR Program, the National Shoreline Management Study, and the RSM Program. Permission was granted by the Chief of Engineers to publish this information. Any use of trade names or products is for descriptive purposes and does not imply endorsement by the U.S. Government. NR 125 TC 0 Z9 0 U1 3 U2 38 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD SPR PY 2013 SI 63 BP 141 EP 165 DI 10.2112/SI63-013.1 PG 25 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA 173KE UT WOS:000321077600013 ER PT J AU Byrnes, MR Rosati, JD Griffee, SF Berlinghoff, JL AF Byrnes, Mark R. Rosati, Julie D. Griffee, Sarah F. Berlinghoff, Jennifer L. TI Historical Sediment Transport Pathways and Quantities for Determining an Operational Sediment Budget: Mississippi Sound Barrier Islands SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE Bathymetric change; shoreline change; Ship Island; Horn Island; Petit Bois Island; channel dredging ID GULF-OF-MEXICO; CHAIN; USA; EVOLUTION; ALABAMA AB Historical shoreline and bathymetric survey data were compiled for the barrier islands and passes fronting Mississippi Sound to identify net littoral sand transport pathways, quantify the magnitude of net sand transport, and develop an operational sediment budget spanning a 90-year period. Net littoral sand transport along the islands and passes is primarily unidirectional (east-to-west). Beach erosion along the east side of each island and sand spit deposition to the west result in an average sand flux of about 400,000 cy/yr (305,000 m(3)/yr) throughout the barrier island system. Dog Keys Pass, located updrift of East Ship Island, is the only inlet acting as a net sediment sink. It also is the widest pass in the system (about 10 km) and has two active channels and ebb shoals. As such, a deficit of sand exists along East Ship Island. Littoral sand transport decreases rapidly along West Ship Island, where exchange of sand between islands terminates because of wave sheltering from the Chandeleur Islands and shoals at the eastern margin of the St. Bernard delta complex, Louisiana. These data were used to assist with design of a large island restoration project along Ship Island; Mississippi. C1 [Byrnes, Mark R.; Griffee, Sarah F.; Berlinghoff, Jennifer L.] Appl Coastal Res & Engn, Mashpee, MA 02649 USA. [Rosati, Julie D.] US Army, Engn Res & Dev Ctr, Coastal & Hydraul Lab, Coastal Inlets Res Program, Vicksburg, MS 39180 USA. RP Byrnes, MR (reprint author), Appl Coastal Res & Engn, 766 Falmouth Rd Suite A-1, Mashpee, MA 02649 USA. EM mbyrnes@appliedcoastal.com FU USACE, Mobile District, Mississippi Coastal Improvements Program (MsCIP) FX The USACE, Mobile District, Mississippi Coastal Improvements Program (MsCIP) funded this project. Authors are grateful for assistance provided by Ms. Susan I. Rees (MsCIP Program Director), Ms. Elizabeth Godsey (USACE), Mr. John Baehr (USACE), Mr. Jason Krick (USACE), Mr. Justin McDonald (USACE), Mr. David Twichell (USGS), Mr. Jeff Williams (USGS), Mr. Jim Woods (National Park Service; NPS), Ms. Rebecca Beavers (NPS), Ms. Linda York (NPS), Mr. Bruce McCraney (NPS), and Mr. Rick Clark (National Park Service; (NPS). Special thanks to two anonymous peer reviewers, whose comments greatly improved the clarity of this manuscript. NR 45 TC 6 Z9 6 U1 3 U2 13 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD SPR PY 2013 SI 63 BP 166 EP 183 DI 10.2112/SI63-014.1 PG 18 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA 173KE UT WOS:000321077600014 ER PT J AU Ahn, J Yang, CT Boyd, PM Pridal, DB Remus, JI AF Ahn, Jungkyu Yang, Chih Ted Boyd, Paul M. Pridal, Daniel B. Remus, John I. TI Numerical modeling of sediment flushing from Lewis and Clark Lake SO INTERNATIONAL JOURNAL OF SEDIMENT RESEARCH LA English DT Article DE Drawdown flushing; Flushing efficiency; GSTARS computer model; Reservoir sedimentation; Sediment transport; Lewis and Clark Lake ID RESERVOIR SEDIMENTATION AB Lewis and Clark Lake is located on the main stream of the Missouri River. The reservoir is formed behind Gavins Point dam near Yankton, South Dakota, U. S. A. The Lewis and Clark Lake reach extends about 40 km from the Gavins Point dam. The reservoir delta has been growing since the closure of Gavins Point dam in 1955 and has resulted in a 21% reduction of storage within the maximum pool of the reservoir. Among several sediment management methods, drawdown flushing has been recommended as a possible management technique. The engineering viability of removing sediments deposited in the lake should be examined by numerical modeling before implementing a drawdown flushing. GSTARS4 was used for this study and calibrated by using measured data from 1975 to 1995. Channel cross-section changes and amount of flushed sediment were predicted with four hypothetical flow scenarios. The flushing efficiencies of all scenarios were estimated by comparing the ratios between water consumption and flushed sediment during flushing. C1 [Ahn, Jungkyu] Seoul Natl Univ, Dept Civil & Environm Engn, Seoul, South Korea. [Yang, Chih Ted] Colorado State Univ, Dept Civil & Environm Engn, Hydrosci & Training Ctr, Ft Collins, CO 80526 USA. [Boyd, Paul M.] US Army Corps Engineers, Omaha, NE USA. [Pridal, Daniel B.] US Army Corps Engineers, Sedimentat & Channel Stabilizat Sect, Omaha, NE USA. [Remus, John I.] Hydrol Engn Branch, Omaha, NE USA. RP Ahn, J (reprint author), Seoul Natl Univ, Dept Civil & Environm Engn, Seoul, South Korea. EM ajk38317@naver.com; ctyang@engr.colostate.edu NR 15 TC 1 Z9 1 U1 0 U2 6 PU IRTCES PI BEIJING PA PO BOX 366, BEIJING, 100044, PEOPLES R CHINA SN 1001-6279 J9 INT J SEDIMENT RES JI Int. J. Sediment Res. PD MAR PY 2013 VL 28 IS 2 BP 182 EP 193 PG 12 WC Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA 174IA UT WOS:000321147500006 ER PT J AU Maruta, J Heaton, KJ Kryskow, EM Maule, AL Ghajar, J AF Maruta, Jun Heaton, Kristin J. Kryskow, Elisabeth M. Maule, Alexis L. Ghajar, Jamshid TI Dynamic visuomotor synchronization: Quantification of predictive timing SO BEHAVIOR RESEARCH METHODS LA English DT Article DE Attention; Smooth pursuit; Test-retest reliability; Concussion; Traumatic brain injury ID PURSUIT EYE-MOVEMENTS; TRAUMATIC BRAIN-INJURY; SMOOTH-PURSUIT; PARKINSONS-DISEASE; COGNITIVE CONTROL; CEREBRAL CONTROL; TARGET MOTIONS; ATTENTION; TRACKING; DEFICITS AB When a moving target is tracked visually, spatial and temporal predictions are used to circumvent the neural delay required for the visuomotor processing. In particular, the internally generated predictions must be synchronized with the external stimulus during continuous tracking. We examined the utility of a circular visual-tracking paradigm for assessment of predictive timing, using normal human subjects. Disruptions of gaze-target synchronization were associated with anticipatory saccades that caused the gaze to be temporarily ahead of the target along the circular trajectory. These anticipatory saccades indicated preserved spatial prediction but suggested impaired predictive timing. We quantified gaze-target synchronization with several indices, whose distributions across subjects were such that instances of extremely poor performance were identifiable outside the margin of error determined by test-retest measures. Because predictive timing is an important element of attention functioning, the visual-tracking paradigm and dynamic synchronization indices described here may be useful for attention assessment. C1 [Maruta, Jun; Ghajar, Jamshid] Brain Trauma Fdn, New York, NY 10007 USA. [Heaton, Kristin J.; Kryskow, Elisabeth M.; Maule, Alexis L.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Heaton, Kristin J.; Maule, Alexis L.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. [Ghajar, Jamshid] Weill Cornell Med Coll, Dept Neurol Surg, New York, NY USA. RP Maruta, J (reprint author), Brain Trauma Fdn, 7 World Trade Ctr,34th Floor,250 Greenwich St, New York, NY 10007 USA. EM jmaruta@braintrauma.org RI Heaton, Kristin/E-3660-2013; OI Maruta, Jun/0000-0002-5054-6605 NR 55 TC 12 Z9 12 U1 0 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1554-351X J9 BEHAV RES METHODS JI Behav. Res. Methods PD MAR PY 2013 VL 45 IS 1 BP 289 EP 300 DI 10.3758/s13428-012-0248-3 PG 12 WC Psychology, Mathematical; Psychology, Experimental SC Psychology GA 156DK UT WOS:000319800900027 PM 22956395 ER PT J AU Abadie, JM AF Abadie, Jude M. TI How Can a Methadone and an Opiate-Positive Immunoassay Result be Reconciled in a Patient Prescribed only OxyContin and Wellbutrin? SO ANNALS OF CLINICAL AND LABORATORY SCIENCE LA English DT Article DE Urine Drug Testing; Pain management; methadone; oxycodone ID TOXICOLOGY AB Appropriate management of patients in pain clinics can be complex and sometimes confusing because providers must correctly interpret multiple sources of patient information. The correct interpretation of laboratory results is essential to guide subsequent patient treatment and management; however, laboratory and clinical pictures can appear to be conflicting in cases of substance abuse. Incorrect interpretation of laboratory results can multiply negative impacts on clinical outcomes and may lead to patient harm or death. This report introduces the complex nature involved in understanding and interpreting urine drug testing (UDT) results in pain patients who are prescribed opioid medications. Laboratory testing examples of UDT results are,provided to illustrate the sometimes discordant nature of UDT interpretation. This case study describes one method of approaching cases where laboratory result interpretation in pain clinic patients is essential for medical treatment and management. The case presented in this manuscript illustrates a reconciliation of an opiate positive immunoassay result in a patient who was prescribed only OxyContin and Wellbutrin after traumatic amputations. C1 [Abadie, Jude M.] Tripler Army Med Ctr, Dept Pathol, Honolulu, HI 96859 USA. RP Abadie, JM (reprint author), Point Care Testing Tripler Army Med Ctr, Out Patient Lab, Core Lab, Dept Pathol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM jude.abadie@amedd.army.mil NR 15 TC 0 Z9 0 U1 0 U2 2 PU ASSOC CLINICAL SCIENTISTS PI MIDDLEBURY PA PO BOX 1287, MIDDLEBURY, VT 05753 USA SN 0091-7370 J9 ANN CLIN LAB SCI JI Ann. Clin. Lab. Sci. PD SPR PY 2013 VL 43 IS 2 BP 190 EP 194 PG 5 WC Medical Laboratory Technology SC Medical Laboratory Technology GA 146PO UT WOS:000319103200013 PM 23694796 ER PT J AU Houpt, JT Leach, GJ Williams, LR Johnson, MS Reddy, G AF Houpt, John T. Leach, Glenn J. Williams, Larry R. Johnson, Mark S. Reddy, Gunda TI Toxicity Assessment of 4-Amino-2-Nitrotoluene SO INTERNATIONAL JOURNAL OF TOXICOLOGY LA English DT Article DE 4-amino-2-nitrotoluene; CAS 119-32-4; oral toxicity; benchmark dose; RfD ID SUBCHRONIC TOXICITY; FISCHER-344 RATS; 2,4-DINITROTOLUENE; 1,3,5-TRINITROBENZENE; DINITROTOLUENE; RESTRICTION; TESTIS AB 4-Amino-2-nitrotoluene (4A2NT; CAS 119-32-4) is a degradation product of 2,4-dinitrotoluene. The toxicity data on 4A2NT are limited. Therefore, we collected toxicity data from rats to assess environmental and human health effects from exposures. The approximate lethal dose for both sexes was 5000 mg/kg. A 14-day toxicity study in rats was conducted with 4A2NT in the feed at concentrations of 0, 125, 250, 500, 1000, and 2000 ppm. Based on a 14-day oral dose range toxicity study with 4A2NT in the feed, 2000 ppm was selected as highest concentration for a subsequent 90-day study. An oral 90-day subchronic toxicity study in rats was conducted with concentrations of 0, 500, 1000, or 2000 ppm of 4A2NT in the feed. The calculated consumed doses of 4A2NT in the feed were 0, 27, 52, or 115 mg/kg/d for males and 0, 32, 65, or 138 mg/kg/d for females. A no-observed adverse effect level could not be determined. The lowest observed adverse effect level was 27 mg/kg/d for males and 32 mg/kg/d for female rats based upon decreased body weight gain. The decreased body weight gain in male rats was the most sensitive adverse event observed in this study and was used to derive a benchmark dose (BMD). A BMD of 23.1 mg/kg/d and BMD with 10% effect level of 15.5 mg/kg/d were calculated for male rats, which were used to derive an oral reference dose (RfD). The human RfD of 1.26 mg/kg/d was derived using current United States Environmental Protection Agency guidelines. C1 [Houpt, John T.; Leach, Glenn J.; Williams, Larry R.; Johnson, Mark S.] USA, Publ Hlth Command, Army Inst Publ Hlth, Aberdeen Proving Ground, MD 21010 USA. [Reddy, Gunda] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. RP Reddy, G (reprint author), USA, Inst Publ Hlth, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM gunda.reddy@us.army.mil FU Installation Management Command/Army Environmental Command, Fort Sam Houston, Texas FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Installation Management Command/Army Environmental Command, Fort Sam Houston, Texas. NR 29 TC 1 Z9 1 U1 0 U2 4 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1091-5818 J9 INT J TOXICOL JI Int. J. Toxicol. PD MAR-APR PY 2013 VL 32 IS 2 BP 113 EP 122 DI 10.1177/1091581813480408 PG 10 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 148EX UT WOS:000319227000003 PM 23493902 ER PT J AU Rose, G McChrystal, S AF Rose, Gideon McChrystal, Stanley TI Generation Kill A Conversation With Stanley McChrystal SO FOREIGN AFFAIRS LA English DT Editorial Material C1 [McChrystal, Stanley] USA, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU COUNCIL FOREIGN RELAT IONS INC PI NEW YORK PA HAROLD PRATT HOUSE, 58 E 68TH ST, NEW YORK, NY 10065 USA SN 0015-7120 J9 FOREIGN AFF JI Foreign Aff. PD MAR-APR PY 2013 VL 92 IS 2 BP 2 EP + PG 6 WC International Relations SC International Relations GA 145NO UT WOS:000319023900001 ER PT J AU Knox, JB Knox, JA Wimberly, RL Riccio, AI AF Knox, Jeffrey Bruce Knox, Jennifer Asarias Wimberly, Robert Lane Riccio, Anthony I. TI Flexion-distraction Injuries in Children and Adolescents SO ORTHOPEDICS LA English DT Review ID SEAT-BELT INJURIES; PEDIATRIC CHANCE FRACTURES; SPINE; RESTRAINTS; CRASHES AB Flexion-distraction injuries represent an uncommon pattern of injury in the pediatric population. Although this is a well-studied topic in adults, the literature on such injuries in children and adolescents is relatively sparse, with only low levels of evidence available to guide treatment. These injuries carry a high rate of concomitant injuries and a high morbidity and mortality in this population. Proper understanding of these complex injuries is important to ensure proper management and avoid complications. C1 [Knox, Jeffrey Bruce] Tripler Army Med Ctr, Orthoped Surg Serv, Honolulu, HI 96859 USA. [Knox, Jennifer Asarias] Tripler Army Med Ctr, Gen Surg Serv, Honolulu, HI 96859 USA. [Wimberly, Robert Lane; Riccio, Anthony I.] Texas Scottish Rite Hosp Children, Dallas, TX 75219 USA. [Wimberly, Robert Lane; Riccio, Anthony I.] Childrens Med Ctr, Dallas, TX 75235 USA. RP Knox, JB (reprint author), Tripler Army Med Ctr, Orthoped Surg Serv, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM jknox49@gmail.com NR 30 TC 0 Z9 0 U1 0 U2 1 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0147-7447 J9 ORTHOPEDICS JI Orthopedics PD MAR PY 2013 VL 36 IS 3 BP 214 EP 218 DI 10.3928/01477447-20130222-09 PG 5 WC Orthopedics SC Orthopedics GA 136EZ UT WOS:000318346100033 PM 23464942 ER PT J AU Watson, JR Siska, P Wolfel, RL AF Watson, Jeffrey R. Siska, Peter Wolfel, Richard L. TI Assessing Gains in Language Proficiency, Cross-Cultural Competence, and Regional Awareness During Study Abroad: A Preliminary Study SO FOREIGN LANGUAGE ANNALS LA English DT Article DE cross-cultural competence; internationalization; language proficiency; regional awareness; study abroad outcomes assessment ID CURRICULUM; STUDENTS AB As a critical part of the internationalization movement in college curricula, study abroad initiatives are becoming more and more popular and the need to assess their outcomes more and more evident. While numerous studies have investigated the language gain associated with study abroad, researchers are also beginning to look at potential gains in the areas of cultural and regional competence. This study presents a theoretical background for a three-tiered model for assessing student outcomes during study abroad in three domainslanguage proficiency, cross-cultural competence, and regional awarenessand presents the quantitative data gathered from the implementation of this model. Results show the feasibility of assessing these outcomes in a holistic manner through formal assessment instruments and participant coaching pre- and post-immersion. C1 [Watson, Jeffrey R.; Wolfel, Richard L.] US Mil Acad, West Point, NY 10996 USA. [Siska, Peter] US Mil Acad, Ctr Languages Cultures & Reg Studies, West Point, NY 10996 USA. RP Watson, JR (reprint author), US Mil Acad, West Point, NY 10996 USA. OI Watson, Jeff/0000-0003-1948-6859 NR 46 TC 6 Z9 6 U1 0 U2 16 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0015-718X J9 FOREIGN LANG ANN JI Foreign Lang. Ann. PD MAR PY 2013 VL 46 IS 1 BP 62 EP 79 DI 10.1111/flan.12016 PG 18 WC Education & Educational Research; Linguistics SC Education & Educational Research; Linguistics GA 134SR UT WOS:000318235300006 ER PT J AU Sanamyan, T Pavlacka, R Gilde, G Dubinskii, M AF Sanamyan, T. Pavlacka, R. Gilde, G. Dubinskii, M. TI Spectroscopic properties of Er3+-doped alpha-Al2O3 SO OPTICAL MATERIALS LA English DT Article ID LASERS; SAPPHIRE; CORUNDUM; ER3+ AB We present the results of comprehensive spectroscopic study of the recently successfully synthesized nanopowders and fully densified transparent ceramics of Er3+-doped alpha-Al2O3 (corundum). Fluorescence and excitation spectra in a range of temperatures of 10-300 K were used to infer the energy level schemes of the ground state and the first three excited Er3+ multiplets (I-4(15/2), I-4(13/2), I-4(11/2), and I-4(9/2)) in this material. Obtained experimental data also allowed us to assess this material as a potential gain medium for high power laser applications in anticipation that it becomes available in the low-loss grain-aligned ceramic or single crystalline form in the near future. Published by Elsevier B.V. C1 [Sanamyan, T.; Dubinskii, M.] USA, Res Lab, RDRL SEE M, Adelphi, MD 20783 USA. [Pavlacka, R.; Gilde, G.] USA, Res Lab, RDRL WMM E, Aberdeen Proving Ground, MD 21005 USA. RP Sanamyan, T (reprint author), USA, Res Lab, RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM tigran.sanamyan@us.army.mil FU High Energy Laser Joint Technology Office FX The authors gratefully acknowledge financial support of this work by the High Energy Laser Joint Technology Office. The authors also thank T. Parker and J. Demaree of U.S. Army Research Laboratory for their assistance in conducting and interpreting the RBS results. NR 23 TC 1 Z9 1 U1 4 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0925-3467 J9 OPT MATER JI Opt. Mater. PD MAR PY 2013 VL 35 IS 5 BP 821 EP 826 DI 10.1016/j.optmat.2012.10.036 PG 6 WC Materials Science, Multidisciplinary; Optics SC Materials Science; Optics GA 128WQ UT WOS:000317800800001 ER PT J AU Schafer, JL Breslow, BP Just, MG Hohmann, MG Hollingsworth, SN Swatling-Holcomb, SL Hoffmann, WA AF Schafer, Jennifer L. Breslow, Bradley P. Just, Michael G. Hohmann, Matthew G. Hollingsworth, Stephanie N. Swatling-Holcomb, Samantha L. Hoffmann, William A. TI Current and Historical Variation in Wiregrass (Aristida stricta) Abundance and Distribution Is Not Detectable from Soil delta C-13 Measurements in Longleaf Pine (Pinus palustris) Savannas SO CASTANEA LA English DT Article DE Carbon; depth profiles; ecotone; pocosin; species distributions ID SOUTHEASTERN UNITED-STATES; PAST VEGETATION CHANGES; ORGANIC-MATTER; CARBON ISOTOPES; NORTH-CAROLINA; ECOSYSTEM; FIRE; PRODUCTIVITY; CLIMATE; FOREST AB Plant species distributions and transitions between vegetation types are determined by numerous factors, including disturbances such as fire. Documentation of past changes in the distribution and structure of fire-dependent ecosystems is necessary to assess the success of land management in maintaining historic vegetation types. In our study system-longleaf pine (Pinus palustris)-wiregrass (Aristida stricta) savannas and embedded wetlands (i.e., pocosins)-wiregrass is dependent on frequent burning. We used soil carbon (C) isotopes to test for past changes in the abundance of wiregrass and for shifts in the ecotone between savanna and pocosin in four sites at Fort Bragg, North Carolina. Wiregrass has a C-4 photosynthetic pathway and therefore produces organic matter enriched in C-13 compared to other dominant species in the community that have a C-3 photosynthetic pathway. At each of the four sites, we measured profiles of soil delta C-13 to a depth of 1 m at four locations along the vegetation gradient from upland savannas to lowland pocosins. Surface soil delta C-13, which reflects C inputs from current vegetation, did not differ along the gradient despite a decrease in wiregrass cover from savanna, where it is abundant, to pocosin, where it is absent. Enrichment of soil delta C-13 with depth was indistinguishable from effects of decomposition, indicating that past variation in the abundance and distribution of wiregrass was not detectable in our study sites. Our results suggest that wiregrass currently does not produce, and historically has not produced, enough biomass to influence soil delta C-13 values along the savanna-pocosin gradient. C1 [Schafer, Jennifer L.; Breslow, Bradley P.; Just, Michael G.; Hollingsworth, Stephanie N.; Swatling-Holcomb, Samantha L.; Hoffmann, William A.] N Carolina State Univ, Dept Plant Biol, Raleigh, NC 27695 USA. [Hohmann, Matthew G.] US Army Corps Engineers, Engineer Res & Dev Ctr, Champaign, IL 61826 USA. RP Schafer, JL (reprint author), N Carolina State Univ, Dept Plant Biol, 2115 Gardner Hall,Box 7612, Raleigh, NC 27695 USA. EM jlschafe@ncsu.edu OI Just, Michael/0000-0003-2493-9269 FU US Army Engineer Research and Development Center [W9132T-11-2-007] FX We thank Janet B. Gray for logistical support. This research was supported by a grant (W9132T-11-2-007) from the US Army Engineer Research and Development Center to W. Hoffmann. NR 46 TC 2 Z9 2 U1 1 U2 62 PU SOUTHERN APPALACHIAN BOTANICAL SOC, NEWBERRY COLL PI NEWBERRY PA DEPT BIOLOGY, C/O CHARLES N HORN, SECRETARY-TREASURER, 2100 COLLEGE ST, NEWBERRY, SC 29108 USA SN 0008-7475 EI 1938-4386 J9 CASTANEA JI Castanea PD MAR PY 2013 VL 78 IS 1 BP 28 EP 36 DI 10.2179/12-021 PG 9 WC Plant Sciences SC Plant Sciences GA 124EF UT WOS:000317445900004 ER PT J AU Hill, AA Wong, L Gerras, SJ AF Hill, Andrew A. Wong, Leonard Gerras, Stephen J. TI "Self-Interest Well Understood": The Origins & Lessons of Public Confidence in the Military SO DAEDALUS LA English DT Article AB In recent decades, the U.S. military has enjoyed high levels of public confidence. We argue that the rise (and sustainment) of public confidence in the military reflects two phenomena. First, the public has a high regard for the military and its mission, arising from a shift to a professional (nonconscript) force that is perceived to be competent, fair, and accountable. Second, the public has little fear of military abuses in the domestic arena, owing chiefly to the reduced domestic presence of the military in the post-World War II era, with less emphasis on the physical defense of the homeland; and to the military's careful cultivation of an apolitical culture since Vietnam. We conclude with a brief discussion of the military's efforts to develop and encourage public-mindedness among its members, and the challenges to replicating the military approach in other institutional settings. C1 [Hill, Andrew A.; Gerras, Stephen J.] USA, War Coll, Dept Command Leadership & Management, Washington, DC 20310 USA. [Wong, Leonard] USA, War Coll, Strateg Studies Inst, Washington, DC USA. [Wong, Leonard; Gerras, Stephen J.] USA, Washington, DC USA. RP Hill, AA (reprint author), USA, War Coll, Dept Command Leadership & Management, Washington, DC 20310 USA. NR 13 TC 1 Z9 1 U1 0 U2 0 PU MIT PRESS PI CAMBRIDGE PA 55 HAYWARD STREET, CAMBRIDGE, MA 02142 USA SN 0011-5266 J9 DAEDALUS-US JI Daedalus PD SPR PY 2013 VL 142 IS 2 BP 49 EP 64 PG 16 WC Humanities, Multidisciplinary; Social Sciences, Interdisciplinary SC Arts & Humanities - Other Topics; Social Sciences - Other Topics GA 124GU UT WOS:000317452600007 ER PT J AU Center, TD Parys, K Grodowitz, M Wheeler, GS Dray, FA O'Brien, CW Johnson, S Cofrancesco, A AF Center, Ted D. Parys, Katherine Grodowitz, Mike Wheeler, Gregory S. Dray, F. Allen O'Brien, Charles W. Johnson, Seth Cofrancesco, Al TI EVIDENCE OF ESTABLISHMENT OF BAGOUS HYDRILLAE (COLEOPTERA: CURCULIONIDAE), A BIOLOGICAL CONTROL AGENT OF HYDRILLA VERTICILLATA (HYDROCHARITALES: HYDROCHARITACEAE) IN NORTH AMERICA? SO FLORIDA ENTOMOLOGIST LA English DT Article DE aquatic weeds; Bagous restrictus; biocontrol agent release; biocontrol agent establishment; herbivory; phytophagous insects ID AQUATIC WEED; AUSTRALIA; LEPIDOPTERA; PYRALIDAE; EVOLUTION; INSECTS; RELEASE AB The semi-aquatic weevil Bagous hydrillae was released during 1991-1996 at 19 sites in 4 states in attempts to control the aquatic weed hydrilla, Hydrilla verticillata. Fourteen of the sites were in Florida, 2 each in Texas and Georgia and one site in Alabama. Over 320,000 adult weevils were included in these releases. Despite the fact that a few adults were recovered as late as 4.5 yr post-release, presence of permanent, self-perpetuating populations was never confirmed. Then, during 2009 adult B. hydrillae were collected in southern Louisiana, at least 580 km from the nearest release site and 13 yr after attempts to establish this insect had terminated. This suggests that earlier recoveries were indicative of successful establishment and that this weevil species has persisted and dispersed widely in the southeastern USA. Nonetheless, there is no evidence that B. hydrillae has had a suppressive effect on hydrilla. C1 [Center, Ted D.; Wheeler, Gregory S.; Dray, F. Allen] USDA ARS, Invas Plant Res Lab, Ft Lauderdale, FL 33314 USA. [Parys, Katherine; Johnson, Seth] Louisiana State Univ, Ctr Agr, Dept Entomol, Louisiana Agr Expt Stn, Baton Rouge, LA 70803 USA. [Grodowitz, Mike; Cofrancesco, Al] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [O'Brien, Charles W.] Univ Arizona, Dept Entomol, Tucson, AZ 85721 USA. RP Center, TD (reprint author), USDA ARS, Invas Plant Res Lab, 3225 Coll Ave, Ft Lauderdale, FL 33314 USA. EM Ted.Center@ars.usda.gov OI Parys, Katherine/0000-0001-7459-3687 FU LSU AgCenter; Louisiana State Department of Wildlife and Fisheries; Florida Department of Environmental Protection; US Army Corps of Engineers; Southwest Florida Water Management District; USDA/ARS FX A. Bishop, L. Bishop, W. C. Durden, L. Kasarjian, and B. Maharajh, USDA-ARS, Invasive Plant Research Laboratory, assisted in the rearing, release, and followup field work during the early years. Thanks to J. Fryoux and A. Meszaros for field assistance in Louisiana. We also thank R. S. Anderson, Canadian Museum of Nature, Ottawa, Ontario, Canada for confirmation of weevil identifications, J. Boyce for access to his property, and LSU AgCenter and Louisiana State Department of Wildlife and Fisheries for funding. The Florida Department of Environmental Protection, US Army Corps of Engineers, Southwest Florida Water Management District, and USDA/ARS provided funding for the initial project and their support is greatly appreciated. NR 30 TC 4 Z9 4 U1 0 U2 20 PU FLORIDA ENTOMOLOGICAL SOC PI LUTZ PA 16125 E LAKE BURRELL DR, LUTZ, FL 33548 USA SN 0015-4040 J9 FLA ENTOMOL JI Fla. Entomol. PD MAR PY 2013 VL 96 IS 1 BP 180 EP 186 PG 7 WC Entomology SC Entomology GA 123HO UT WOS:000317379200024 ER PT J AU Sitaraman, J Potsdam, M Wissink, A Jayaraman, B Datta, A Mavriplis, D Saberi, H AF Sitaraman, Jayanarayanan Potsdam, Mark Wissink, Andrew Jayaraman, Buvaneswari Datta, Anubhav Mavriplis, Dimitri Saberi, Hossein TI Rotor Loads Prediction Using Helios: A Multisolver Framework for Rotorcraft Aeromechanics Analysis SO JOURNAL OF AIRCRAFT LA English DT Article; Proceedings Paper CT 49th AIAA Aerospace Sciences Meeting/New Horizons Forum and Aerospace Exposition CY JAN 03-17, 2011 CL Orlando, FL SP AIAA AB This paper documents the prediction of UH-60A Black Hawk aerodynamic loading using the multisolver Computational Fluid Dynamics/Computational Structural Dynamics analysis framework for rotorcraft Helios for a range of critical steady forward flight conditions. Comparisons with available flight test data are provided for all of the predictions. The Helios framework combines multiple solvers and multiple grid paradigms (unstructured and adaptive Cartesian) such that the advantages of each paradigm is preserved. Further, the software is highly automated for execution and designed in a modular fashion to minimize the burden on both the users and developers. The technical approach presented herein provides details of all of the participant modules and the interfaces used for their integration into the software framework. The results composed of sectional aerodynamic loading and wake visualizations are presented. Solution-based adapative mesh refinement, a salient feature of the Helios framework, is explored for all flight conditions and comparisons are provided for both aerodynamic loading and vortex wake structure with and without adaptive mesh refinement. C1 [Sitaraman, Jayanarayanan; Mavriplis, Dimitri] Univ Wyoming, Dept Mech Engn, Laramie, WY 82071 USA. [Potsdam, Mark] USA, Aeroflightdynam Directorate, Res Dev & Engn Command, Moffett Field, CA 94035 USA. [Wissink, Andrew] USA, Aeroflightdynam Directorate, Sci & Technol Corp, Moffett Field, CA 94035 USA. [Jayaraman, Buvaneswari; Datta, Anubhav] NASA, Ames Res Ctr, Sci & Technol Corp, Moffett Field, CA 94035 USA. [Saberi, Hossein] Adv Rotorcraft Technol Inc, Sunnyvale, CA 94085 USA. RP Sitaraman, J (reprint author), Univ Wyoming, Dept Mech Engn, Laramie, WY 82071 USA. EM saberi@flightlab.com NR 26 TC 4 Z9 4 U1 0 U2 3 PU AMER INST AERONAUTICS ASTRONAUTICS PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0021-8669 J9 J AIRCRAFT JI J. Aircr. PD MAR-APR PY 2013 VL 50 IS 2 BP 478 EP 492 DI 10.2514/1.C031897 PG 15 WC Engineering, Aerospace SC Engineering GA 122MJ UT WOS:000317321900015 ER PT J AU Yeo, H AF Yeo, Hyeonsoo TI Investigation of UH-60A Rotor Performance and Loads at High Advance Ratios SO JOURNAL OF AIRCRAFT LA English DT Article; Proceedings Paper CT 68th Annual Forum of the American-Helicopter-Society CY MAY 01-03, 2012 CL Fort Worth, TX SP Amer Helicopter Soc ID COMPREHENSIVE ANALYSIS; HELICOPTER ROTORS AB Wind tunnel measurements of the performance, airloads, and structural loads of a full-scale UH-60A Black Hawk main rotor operating at high advance ratios (up to 1.0) are compared with calculations obtained using the comprehensive rotorcraft analysis Comprehensive Analytical Model of Rotorcraft Aerodynamics and Dynamics II to understand physics and quantify this comprehensive code's accuracy and reliability in the prediction of rotor performance and loads at high advance ratios. Detailed comparisons are made on rotor thrust, control angles, power, and section loads to illustrate and understand unique aeromechanics phenomena in this regime. The analysis correctly predicts the thrust reversal with collective at high advance ratios. Rotor induced plus profile power is also reasonably well predicted with proper modeling of the shank. Airloads and structural loads correlation is fair. A significant underprediction of 2-per-revolution structural loads is observed. C1 USA, Aeroflightdynam Directorate AMRDEC, Ames Res Ctr, Res Dev & Engn Command, Moffett Field, CA 94035 USA. RP Yeo, H (reprint author), USA, Aeroflightdynam Directorate AMRDEC, Ames Res Ctr, Res Dev & Engn Command, Moffett Field, CA 94035 USA. EM hyeonsoo.yeo@us.army.mil NR 31 TC 7 Z9 7 U1 0 U2 1 PU AMER INST AERONAUTICS ASTRONAUTICS PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0021-8669 J9 J AIRCRAFT JI J. Aircr. PD MAR-APR PY 2013 VL 50 IS 2 BP 576 EP 589 DI 10.2514/1.C031958 PG 14 WC Engineering, Aerospace SC Engineering GA 122MJ UT WOS:000317321900023 ER PT J AU Gilman, S AF Gilman, S. TI Coulometric study of rates of oxalic acid adsorption at a polycrystalline Platinum Electrode SO JOURNAL OF ELECTROANALYTICAL CHEMISTRY LA English DT Article DE Ion adsorption; Oxalic acid adsorption; Oxalic acid; Ethylene glycol fuel cell; Fuel cell ID SINGLE-CRYSTAL ELECTRODES; ETHYLENE-GLYCOL; TRACER METHODS; ANION ADSORPTION; OXIDATION; BEHAVIOR; OXALATE AB Quantitative measurement of adsorption/desorption of oxalic acid on a Pt electrode from a perchloric acid supporting electrolyte has been accomplished for the first time using a fast potential scan preceded by a sequence of potential steps. From a dilute solution of oxalic acid, adsorption as the oxalate/bioxylate anion is so rapid as to be diffusion-controlled over the range of potentials at which the surface is free of adsorbed oxygen; most of the final coverage achieved in less than a half-second. Cathodic desorption of the adsorbed anions occurs in the millisecond range. An isotherm for reversible adsorption applies to the range 0-0.9 V vs. a RHE but below 0.3 V, there is conversion to irreversible adsorption that is perceptible after hundreds of seconds. Irreversible adsorption as carbon monoxide blocks cathodic hydrogen underpotential deposition (upd) while adsorption as anions does not because the latter desorb at upd potentials. Adsorbed oxalic acid has a negative effect on the anodic oxidation of ethylene glycol and the reduction of molecular oxygen. (C) 2013 Elsevier B.V. All rights reserved. C1 USA, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA. RP Gilman, S (reprint author), USA, Sensors & Electron Devices Directorate, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM sol.gilman.civ@mail.mil NR 26 TC 3 Z9 3 U1 1 U2 9 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 1572-6657 J9 J ELECTROANAL CHEM JI J. Electroanal. Chem. PD MAR 1 PY 2013 VL 692 BP 53 EP 59 DI 10.1016/j.jelechem.2013.01.013 PG 7 WC Chemistry, Analytical; Electrochemistry SC Chemistry; Electrochemistry GA 122ML UT WOS:000317322100008 ER PT J AU Staab, JE Beidleman, BA Muza, SR Fulco, CS Rock, PB Cymerman, A AF Staab, Janet E. Beidleman, Beth A. Muza, Stephen R. Fulco, Charles S. Rock, Paul B. Cymerman, Allen TI Efficacy of Residence at Moderate Versus Low Altitude on Reducing Acute Mountain Sickness in Men Following Rapid Ascent to 4300 m SO HIGH ALTITUDE MEDICINE & BIOLOGY LA English DT Article DE acute mountain sickness; hypobaric hypoxia; acclimatization; fluid balance; ventilatory response to hypoxia ID CARBOHYDRATE SUPPLEMENTATION; HYPOBARIC HYPOXIA; HEMOGLOBIN MASS; EXERCISE; ACCLIMATIZATION; QUESTIONNAIRE; PERFORMANCE; SYMPTOMS; NATIVES; BALANCE AB Staab, Janet E., Beth A. Beidleman, Stephen R. Muza, Charles S. Fulco, Paul B. Rock, and Allen Cymerman. Efficacy of residence at moderate versus low altitude on reducing acute mountain sickness in men following rapid ascent to 4300 m. High Alt Med Biol 14:13-18, 2013.-To determine if residence at moderate (similar to 2000 m) compared to low (<50 m) altitude reduces acute mountain sickness (AMS) in men during subsequent rapid ascent to a higher altitude. Nine moderate-altitude residents (MAR) and 18 sea-level residents (SLR) completed the Environmental Symptoms Questionnaire (ESQ) at their respective baseline residence and again at 12, 24, 48, and 72 h at 4300m to assess the severity and prevalence of AMS. AMS cerebral factor score (AMS-C) was calculated from the ESQ at each time point. AMS was judged to be present if AMS-C was >= 0.7. Resting end-tidal CO2 (P-ETCO2) and arterial oxygen saturation (Sa(O2)) were assessed prior to and at 24, 48, and 72 h at 4300 m. Resting venous blood samples were collected prior to and at 72 h at 4300m to estimate plasma volume (PV) changes. MAR compared to SLR: 1) AMS severity at 4300 was lower (p < 0.05) at 12 h (0.50 +/- 0.69 vs. 1.48 +/- 1.28), 24 h (0.15 +/- 0.19 vs. 1.39 +/- 1.19), 48 h (0.10 +/- 0.18 vs. 1.37 +/- 1.49) and 72 h (0.08 +/- 0.12 vs. 0.69 +/- 0.70); 2) AMS prevalence at 4300 was lower (p < 0.05) at 12 h (22% vs. 72%), 24 h (0% vs. 56%), 48 h (0% vs. 56%), and 72 h (0% vs. 45%); 3) resting Sa(O2) (%) was lower (p < 0.05) at baseline (95 +/- 1 vs. 99 +/- 1) but higher (p < 0.05) at 4300 at 24 h (86 +/- 2 vs. 81 +/- 5), 48 h (88 +/- 3 vs. 83 +/- 6), and 72 h (88 +/- 2 vs. 83 +/- 5); and 4) PV (%) did not differ at 72 h at 4300 m in the MAR (4.5 +/- 6.7) but was reduced for the SLR (-8.1 +/- 10.4). These results suggest that ventilatory and hematological acclimatization acquired while living at moderate altitude, as indicated by a higher resting Sa(O2) and no reduction in PV during exposure to a higher altitude, is associated with greatly reduced AMS after rapid ascent to high altitude. C1 [Staab, Janet E.; Beidleman, Beth A.; Muza, Stephen R.; Fulco, Charles S.; Cymerman, Allen] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. [Rock, Paul B.] Oklahoma State Univ, Ctr Hlth Sci, Ctr Aerosp & Hyperbar Med, Tulsa, OK USA. RP Staab, JE (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, 42 Kansas St, Natick, MA 01760 USA. EM janet.staab@us.army.mil NR 28 TC 4 Z9 4 U1 1 U2 11 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1527-0297 J9 HIGH ALT MED BIOL JI High Alt. Med. Biol. PD MAR PY 2013 VL 14 IS 1 BP 13 EP 18 DI 10.1089/ham.2012.1065 PG 6 WC Biophysics; Public, Environmental & Occupational Health; Sport Sciences SC Biophysics; Public, Environmental & Occupational Health; Sport Sciences GA 116CJ UT WOS:000316859800003 PM 23537255 ER PT J AU Schiffer, JM Maniatis, P Garza, I Steward-Clark, E Korman, LT Pittman, PR Mei, JV Quinn, CP AF Schiffer, Jarad M. Maniatis, Panagiotis Garza, Ilana Steward-Clark, Evelene Korman, Lawrence T. Pittman, Phillip R. Mei, Joanne V. Quinn, Conrad P. TI Quantitative assessment of anthrax vaccine immunogenicity using the dried blood spot matrix SO BIOLOGICALS LA English DT Article DE Anthrax; Emergency response; Enzyme-linked immunosorbent assay; Dried blood spots; Protective antigen; Assay validation ID LINKED-IMMUNOSORBENT-ASSAY; IMMUNOGLOBULIN-G; ANTIBODIES AB The collection, processing and transportation to a testing laboratory of large numbers of clinical samples during an emergency response situation present significant cost and logistical issues. Blood and serum are common clinical samples for diagnosis of disease. Serum preparation requires significant on-site equipment and facilities for immediate processing and cold storage, and significant costs for cold-chain transport to testing facilities. The dried blood spot (DBS) matrix offers an alternative to serum for rapid and efficient sample collection with fewer on-site equipment requirements and considerably lower storage and transport costs. We have developed and validated assay methods for using DBS in the quantitative anti-protective antigen IgG enzyme-linked immunosorbent asay (ELISA), one of the primary assays for assessing immunogenicity of anthrax vaccine and for confirmatory diagnosis of Bacillus anthracis infection in humans. We have also developed and validated high-throughput data analysis software to facilitate data handling for large clinical trials and emergency response. Published by Elsevier Ltd on behalf of The International Alliance for Biological Standardization. C1 [Schiffer, Jarad M.; Steward-Clark, Evelene; Mei, Joanne V.; Quinn, Conrad P.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Maniatis, Panagiotis; Garza, Ilana] Logist Hlth Inc, La Crosse, WI 54601 USA. [Korman, Lawrence T.; Pittman, Phillip R.] USA, Med Res Inst Infect Dis, Ft Detrick, MD USA. RP Schiffer, JM (reprint author), Ctr Dis Control & Prevent, Microbial Pathogenesis & Immune Response Lab, Meningitis & Vaccine Preventable Dis Branch, Div Bacterial Dis,Natl Ctr Immunizat & Resp Dis, Mail Stop D-01,1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM jschiffer@cdc.gov FU Centers for Disease Control and Prevention, Office for Public Health Preparedness and Response FX This publication was supported by funds made available from the Centers for Disease Control and Prevention, Office for Public Health Preparedness and Response. NR 19 TC 0 Z9 0 U1 0 U2 9 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 1045-1056 J9 BIOLOGICALS JI Biologicals PD MAR PY 2013 VL 41 IS 2 BP 98 EP 103 DI 10.1016/j.biologicals.2012.11.003 PG 6 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Pharmacology & Pharmacy GA 115WX UT WOS:000316843700007 PM 23266055 ER PT J AU Rostkowski, KH Pfluger, AR Criddle, CS AF Rostkowski, Katherine H. Pfluger, Andrew R. Criddle, Craig S. TI Stoichiometry and kinetics of the PHB-producing Type II methanotrophs Methylosinus trichosporium OB3b and Methylocystis parvus OBBP SO BIORESOURCE TECHNOLOGY LA English DT Article DE Type II methanotrophs; Stoichiometry; Kinetics; Polyhydroxybutyrate (PHB) ID METHANE-UTILIZING BACTERIA; NITROGEN-FIXATION; OBLIGATE METHANOTROPHS; AMMONIA ASSIMILATION; METABOLISM; POLY-3-HYDROXYBUTYRATE; POLYHYDROXYALKANOATES; PROTEOBACTERIA; ENRICHMENT; OXIDATION AB In this study, modeling is used to describe how oxygen and nitrogen source affect the stoichiometry and kinetics of growth and PHB production in the Type II methanotrophs Methylosinus trichosporium OB3b and Methylocystis parvus OBBP. Significant differences were observed, with major implications for the use of these species in biotechnology applications. Such analyses can better inform bioreactor design, scale-up models, and life cycle assessments (LCAs). Published by Elsevier Ltd. C1 [Rostkowski, Katherine H.; Criddle, Craig S.] Stanford Univ, Dept Civil & Environm Engn, Stanford, CA 94305 USA. [Pfluger, Andrew R.] US Mil Acad, Dept Geog & Environm Engn, West Point, NY 10996 USA. RP Rostkowski, KH (reprint author), Stanford Univ, Dept Civil & Environm Engn, Stanford, CA 94305 USA. EM khr4@stanford.edu NR 35 TC 13 Z9 14 U1 5 U2 68 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0960-8524 J9 BIORESOURCE TECHNOL JI Bioresour. Technol. PD MAR PY 2013 VL 132 BP 71 EP 77 DI 10.1016/j.biortech.2012.12.129 PG 7 WC Agricultural Engineering; Biotechnology & Applied Microbiology; Energy & Fuels SC Agriculture; Biotechnology & Applied Microbiology; Energy & Fuels GA 113YZ UT WOS:000316707200011 PM 23395757 ER PT J AU Hahs, DW Pethel, SD AF Hahs, Daniel W. Pethel, Shawn D. TI Transfer Entropy for Coupled Autoregressive Processes SO ENTROPY LA English DT Article DE transfer entropy; autoregressive process; Gaussian process; information transfer ID INFORMATION-TRANSFER AB A method is shown for computing transfer entropy over multiple time lags for coupled autoregressive processes using formulas for the differential entropy of multivariate Gaussian processes. Two examples are provided: (1) a first-order filtered noise process whose state is measured with additive noise, and (2) two first-order coupled processes each of which is driven by white process noise. We found that, for the first example, increasing the first-order AR coefficient while keeping the correlation coefficient between filtered and measured process fixed, transfer entropy increased since the entropy of the measured process was itself increased. For the second example, the minimum correlation coefficient occurs when the process noise variances match. It was seen that matching of these variances results in minimum information flow, expressed as the sum of transfer entropies in both directions. Without a match, the transfer entropy is larger in the direction away from the process having the larger process noise. Fixing the process noise variances, transfer entropies in both directions increase with the coupling strength. Finally, we note that the method can be generally employed to compute other information theoretic quantities as well. C1 [Hahs, Daniel W.] Torch Technol Inc, Huntsville, AL 35802 USA. [Pethel, Shawn D.] USA, Huntsville, AL 35898 USA. RP Pethel, SD (reprint author), USA, Huntsville, AL 35898 USA. EM dan.hahs@torchtechnologies.com; shawn.d.pethel.civ@mail.mil NR 13 TC 7 Z9 7 U1 0 U2 7 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1099-4300 J9 ENTROPY-SWITZ JI Entropy PD MAR PY 2013 VL 15 IS 3 BP 767 EP 788 DI 10.3390/e15030767 PG 22 WC Physics, Multidisciplinary SC Physics GA 112PW UT WOS:000316605600003 ER PT J AU Diallo, D Benbouzid, ME Abul Masrur, M AF Diallo, Demba Benbouzid, Mohamed El Hachemi Abul Masrur, M. TI Special Section on Condition Monitoring and Fault Accommodation in Electric and Hybrid Propulsion Systems SO IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY LA English DT Editorial Material C1 [Diallo, Demba] Univ Paris 11, LGEP, UMR 8507, F-91192 Gif Sur Yvette, France. [Benbouzid, Mohamed El Hachemi] Univ Brest, LBMS, EA 4325, F-29238 Brest 03, France. [Abul Masrur, M.] USA, RDECOM TARDEC, RDTA RS, Warren, MI 48397 USA. RP Diallo, D (reprint author), Univ Paris 11, LGEP, UMR 8507, F-91192 Gif Sur Yvette, France. NR 0 TC 4 Z9 4 U1 0 U2 13 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9545 J9 IEEE T VEH TECHNOL JI IEEE Trans. Veh. Technol. PD MAR PY 2013 VL 62 IS 3 BP 962 EP 964 DI 10.1109/TVT.2013.2245731 PG 3 WC Engineering, Electrical & Electronic; Telecommunications; Transportation Science & Technology SC Engineering; Telecommunications; Transportation GA 110TP UT WOS:000316469500001 ER PT J AU Velez, VF Romano, JA McKown, RL Green, K Zhang, LW Raab, RW Ryan, DS Hutnik, CML Frierson, HF Laurie, GW AF Velez, Francisco V. Romano, Jeffrey A. McKown, Robert L. Green, Kari Zhang, Liwen Raab, Ronald W. Ryan, Denise S. Hutnik, Cindy M. L. Frierson, Henry F., Jr. Laurie, Gordon W. TI Tissue Transglutaminase Is a Negative Regulator of Monomeric Lacritin Bioactivity SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Article ID CORNEAL EPITHELIAL-CELLS; PROSECRETORY MITOGEN LACRITIN; GROWTH-FACTOR-BETA; DRY EYE; MASS-SPECTROMETRY; EXPRESSION; ACTIVATION; PROTEIN; IDENTIFICATION; PROLIFERATION AB PURPOSE. Molar accounting of bioactive fluids can expose new regulatory mechanisms in the growing proteomic focus on epithelial biology. Essential for the viability of the surface epithelium of the eye and for normal vision is the thin, but protein-rich, tear film in which the small tear glycoprotein lacritin appears to play a prominent prosecretory, cytoprotective, and mitogenic role. Although optimal bioactive levels in cell culture are 1 to 10 nM over a biphasic dose optimum, ELISA suggests a sustained tear lacritin concentration in the midmicromolar range in healthy adults. Here we identify a reconciling mechanism. METHODS. Monoclonal anti-lacritin 1F5 antibody was generated, and applied together with a new anti-C-terminal polyclonal antibody to tear and tissue Western blotting. In vitro tissue transglutaminase (Tgm2) cross-linking was monitored and characterized by mass spectrometry. RESULTS. Blotting for lacritin in human tears or saliva surprisingly detected immunoreactive material with a higher molecular weight and prominence equal or exceeding the similar to 23 to 25 kDa band of monomeric glycosylated lacritin. Exogenous Tgm2 initiated lacritin cross-linking within 1 minute and was complete by 90 minutes-even with as little as 0.1 nM lacritin, and involved the donors lysine 82 and 85 and the acceptor glutamine 106 in the syndecan-1 binding domain. Lacritin spiked into lacritin-depleted tears formed multimers, in keeping with similar to 0.6 mu M TGM2 in tears. Cross-linking was absent when Tgm2 was inactive, and cross-linked lacritin, unlike recombinant monomer, bound syndecan-1 poorly. CONCLUSIONS. Since syndecan-1 binding is necessary for lacritin mitogenic and cytoprotective activities, TGM2 cross-linking negatively regulates lacritin bioactivity. (Invest Ophthalmol Vis Sci. 2013; 54: 2123-2132) DOI: 10.1167/iovs.12-11488 C1 [Velez, Francisco V.; Romano, Jeffrey A.; Laurie, Gordon W.] Univ Virginia, Dept Cell Biol, Charlottesville, VA 22908 USA. [McKown, Robert L.; Raab, Ronald W.] James Madison Univ, Dept Integrated Sci & Technol, Harrisonburg, VA 22807 USA. [Green, Kari; Zhang, Liwen] Ohio State Univ, Dept Mol & Cellular Biochem, Columbus, OH 43210 USA. [Green, Kari; Zhang, Liwen] Ohio State Univ, Mass Spectrometry & Prote Facil, Columbus, OH 43210 USA. [Ryan, Denise S.] USA, Warfighter Refract Surg Res Ctr Ft Belvoir, Ft Belvoir, VA USA. [Hutnik, Cindy M. L.] Univ Western Ontario, Dept Ophthalmol, London, ON, Canada. [Frierson, Henry F., Jr.] Univ Virginia, Dept Pathol, Charlottesville, VA 22903 USA. [Laurie, Gordon W.] Univ Virginia, Dept Ophthalmol, Charlottesville, VA USA. RP Laurie, GW (reprint author), Univ Virginia, Dept Cell Biol, UVa Hlth Syst, POB 800732, Charlottesville, VA 22908 USA. EM glaurie@virginia.edu RI Zhang, Liwen/P-1111-2016 FU NIH [RO1EY013143, RO1EY018222] FX Supported by NIH RO1EY013143, RO1EY018222 (GWL). NR 39 TC 10 Z9 10 U1 0 U2 2 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR PY 2013 VL 54 IS 3 BP 2123 EP 2132 DI 10.1167/iovs.12-11488 PG 10 WC Ophthalmology SC Ophthalmology GA 117GV UT WOS:000316942400074 ER PT J AU Morrison, JJ Ross, JD Dubose, JJ Jansen, JO Midwinter, MJ Rasmussen, TE AF Morrison, Jonathan J. Ross, James D. Dubose, Joseph J. Jansen, Jan O. Midwinter, Mark J. Rasmussen, Todd E. TI Association of Cryoprecipitate and Tranexamic Acid With Improved Survival Following Wartime Injury Findings From the MATTERs II Study SO JAMA SURGERY LA English DT Article ID ACTIVATED PROTEIN-C; TRAUMA PATIENTS; ACUTE COAGULOPATHY; CONTROLLED-TRIAL; EPIDEMIOLOGY; FIBRINOGEN; HYPERFIBRINOLYSIS; COAGULATION; HEMORRHAGE; DEATH AB Objective: To quantify the impact of fibrinogen-containing cryoprecipitate in addition to the antifibrinolytic tranexamic acid on survival in combat injured. Design: Retrospective observational study comparing the mortality of 4 groups: tranexamic acid only, cryoprecipitate only, tranexamicacidandcryoprecipitate, and neither tranexamic acid nor cryoprecipitate. To balance comparisons, propensity scores were developed and added as covariates to logistic regression models predicting mortality. Setting: A Role 3 Combat Surgical Hospital in southern Afghanistan. Patients: A total of 1332 patients were identified from prospectively collected UK and US trauma registries who required 1 U or more of packed red blood cells and composed the following groups: tranexamic acid (n=148), cryoprecipitate (n=168), tranexamic acid/cryoprecipitate (n=258), and no tranexamic acid/cryoprecipitate (n=758). Main Outcome Measure: In-hospital mortality. Results: Injury Severity Scores were highest in the cryoprecipitate (mean [SD], 28.3 [15.7]) and tranexamic acid/cryoprecipitate (mean [SD], 26 [14.9]) groups compared with the tranexamic acid (mean [SD], 23.0 [19.2]) and no tranexamic acid/cryoprecipitate (mean [SD], 21.2 [18.5]) (P < .001) groups. Despite greater Injury Severity Scores and packed red blood cell requirements, mortality was lowest in the tranexamic acid/cryoprecipitate (11.6%) and tranexamic acid (18.2%) groups compared with the cryoprecipitate (21.4%) and no tranexamic acid/cryoprecipitate (23.6%) groups. Tranexamic acid and cryoprecipitate were independently associated with a similarly reduced mortality (odds ratio, 0.61; 95% CI, 0.420.89; P=.01 and odds ratio, 0.61; 95% CI, 0.40-0.94; P=.02, respectively). The combined tranexamic acid and cryoprecipitate effect vs neither in a synergy model had an odds ratio of 0.34 (95% CI, 0.20-0.58; P < .001), reflecting nonsignificant interaction (P=.21). Conclusions: Cryoprecipitate may independently add to the survival benefit of tranexamic acid in the seriously injured requiring transfusion. Additional study is necessary to define the role of fibrinogen in resuscitation from hemorrhagic shock. JAMA Surg. 2013; 148(3): 218-225. Published online November 19, 2012. doi: 10.1001/jamasurg.2013.764 C1 [Morrison, Jonathan J.] New Queen Elizabeth Hosp, Natl Inst Hlth Res, Birmingham, W Midlands, England. [Morrison, Jonathan J.; Midwinter, Mark J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Jansen, Jan O.] Med Regiment, Parachute Med Squadron 144, Air Assault 16, Colchester, Essex, England. [Morrison, Jonathan J.; Rasmussen, Todd E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Ross, James D.] Lackland AFB, Med Wing Sci & Technol Off 59, San Antonio, TX USA. [Dubose, Joseph J.] C STARS Baltimore, R Adams Cowley Shock Trauma Ctr, Baltimore, MD USA. [Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. RP Rasmussen, TE (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, San Antonio, TX 78234 USA. EM todd.rasmussen@amedd.army.mil RI Midwinter, Mark/P-6264-2015; OI Midwinter, Mark/0000-0003-1836-7137; Morrison, Jonathan/0000-0001-7462-8456 FU Office of the US Air Force Surgeon General; Air Force Medical Support Agency FX This research was funded by the Office of the US Air Force Surgeon General and created in the performance of a contract with the Air Force Medical Support Agency. The governments of Great Britain and the United States have certain rights to use this work. NR 38 TC 43 Z9 44 U1 0 U2 6 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 2168-6254 J9 JAMA SURG JI JAMA Surg. PD MAR PY 2013 VL 148 IS 3 BP 218 EP 225 DI 10.1001/jamasurg.2013.764 PG 8 WC Surgery SC Surgery GA 113QG UT WOS:000316682000002 PM 23670117 ER PT J AU Bogetti, TA Staniszewski, J Burns, BP Hoppel, CPR Gillespie, JW Tierney, J AF Bogetti, Travis A. Staniszewski, Jeffrey Burns, Bruce P. Hoppel, Christopher P. R. Gillespie, John W., Jr. Tierney, John TI Predicting the nonlinear response and progressive failure of composite laminates under triaxial loading: Correlation with experimental results SO JOURNAL OF COMPOSITE MATERIALS LA English DT Article DE Composite laminate; triaxial loading; progressive ply failure; nonlinear response; envelope ID BIAXIAL COMPRESSION; LAYERED COMPOSITES; CAPABILITIES; EXERCISE; BENCHMARKING AB This article represents our contribution to Part B of the 2nd Worldwide Failure Exercise (WWFE-II), where comparisons between epoxy/lamina/laminate response and failure predictions, based on maximum strain failure criterion, and experimental results are made. Correlations between actual test data and our nonlinear stress-strain response and failure envelope predictions under multi-axial loading for 12 different case studies are presented and discussed. Although our approach to modeling composite failure ranked high when applied to biaxial in-plane loading analysis, the theory does not consistently capture the inherent strengthening mechanisms that can be attributed to triaxial loading and hydrostatic pressure. It is expected that the incorporation of a strain-based ply-level failure criterion that introduces some form of strengthening mechanism under a three-dimensional stress state would significantly improve the accuracy of our predictions. C1 [Bogetti, Travis A.; Staniszewski, Jeffrey; Burns, Bruce P.; Hoppel, Christopher P. R.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Gillespie, John W., Jr.; Tierney, John] Univ Delaware, Ctr Composite Mat, Dept Civil & Environm Engn, Newark, DE 19716 USA. [Gillespie, John W., Jr.] Univ Delaware, Dept Mat Sci & Engn, Newark, DE USA. RP Bogetti, TA (reprint author), USA, Res Lab, RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA. EM travis.a.bogetti.civ@mail.mil NR 21 TC 4 Z9 4 U1 0 U2 14 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0021-9983 J9 J COMPOS MATER JI J. Compos Mater. PD MAR PY 2013 VL 47 IS 6-7 SI SI BP 793 EP 804 DI 10.1177/0021998312462616 PG 12 WC Materials Science, Composites SC Materials Science GA 116XN UT WOS:000316916700010 ER PT J AU Doyle, JD Howard, IL AF Doyle, Jesse D. Howard, Isaac L. TI Thermal Cracking Potential of High RAP-WMA Evaluated With Bending Beam Rheometer Mixture Beam Test SO JOURNAL OF TESTING AND EVALUATION LA English DT Article DE asphalt mixture; flexible pavements; reclaimed asphalt pavement; warm mix asphalt; thermal cracking ID RECLAIMED ASPHALT PAVEMENT; TEMPERATURE AB In recent years, increasing cost of the raw materials for asphalt paving has generated interest in using greater quantities of reclaimed asphalt pavement (RAP). During the same period, development of warm-mix asphalt (WMA) technology has allowed use of lower production temperatures that can reduce the amount of short-term aging of the virgin binder. The reduction in short-term aging can be beneficial in reducing problems associated with increased binder stiffness that are normally encountered when using high percentages of RAP in a mixture. This paper presents the results of an investigation that compared the low-temperature performance of WMA with a high RAP content to the performance of mixtures produced in accordance with current practice, which limits the content of RAP in the mixture to 15% or less. Comparisons were made through a combination of mixture testing with the bending beam rheometer (B BR) and thermal cracking analysis of the BBR data. Emphasis was placed on mixture performance when the mixture is used on the surface of highway pavements. Test results from over 1000 beam specimens tested in the BBR are presented, and the results indicate that low-temperature performance of WMA containing 25% RAP is likely to be comparable to performance of surface mixtures produced in accordance with current practice. The test results also indicate WMA containing 50% RAP may be more susceptible to thermal cracking than surface course mixtures produced by the current practice. C1 [Doyle, Jesse D.] USA, Corps Engineers, Engn Res & Dev Ctr, CEERD GM A, Vicksburg, MS 39180 USA. [Howard, Isaac L.] Mississippi State Univ, Dept Civil & Environm Engn, Mississippi State, MS 39762 USA. RP Doyle, JD (reprint author), USA, Corps Engineers, Engn Res & Dev Ctr, CEERD GM A, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM jesse.d.doyle@erdc.dren.mil FU Mississippi DOT Research Division [SS 212] FX Thanks are due to the Mississippi DOT Research Division (James Watkins) for funding SS 212. Permission to publish this paper was granted by the Director, Geotechnical and Structures Laboratory, U.S. Army Engineer Research and Development Center. NR 21 TC 5 Z9 5 U1 3 U2 15 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 USA SN 0090-3973 EI 1945-7553 J9 J TEST EVAL JI J. Test. Eval. PD MAR PY 2013 VL 41 IS 2 BP 236 EP 246 DI 10.1520/JTE20120034 PG 11 WC Materials Science, Characterization & Testing SC Materials Science GA 115UQ UT WOS:000316837800008 ER PT J AU Wilson, DK Valente, D Nykaza, ET Pettit, CL AF Wilson, D. Keith Valente, Dan Nykaza, Edward T. Pettit, Chris L. TI Information-criterion based selection of models for community noise annoyance SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID EXPOSURE AB Statistical evidence for various models relating day-night sound level (DNL) to community noise annoyance is assessed with the Akaike information criterion. In particular, community-specific adjustments such as the community tolerance level (CTL, the DNL at which 50% of survey respondents are highly annoyed) and community tolerance spread (CTS, the difference between the DNL at which 90% and 10% are highly annoyed) are considered. The results strongly support models characterizing annoyance on a community-by-community basis, rather than with complete pooling and analysis of all available surveys. The most likely model was found to be a 2-parameter logistic model, with CTL and CTS fit independently to survey data from each community. C1 [Wilson, D. Keith] USA, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. [Valente, Dan; Nykaza, Edward T.] USA, Engineer Res & Dev Ctr, Champaign, IL 61826 USA. [Pettit, Chris L.] USN Acad, Dept Aerosp Engn, Annapolis, MD 21402 USA. RP Wilson, DK (reprint author), USA, Engineer Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA. EM d.keith.wilson@usace.army.mil; daniel.p.valente@usace.army.mil; edward.t.nykaza@erdc.dren.mil; pettitcl@usna.edu RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 FU U.S. Army Engineer Research and Development Center (ERDC) Geospatial Research and Engineering business area FX This research was funded by the U.S. Army Engineer Research and Development Center (ERDC) Geospatial Research and Engineering business area. Permission to publish was granted by Director, Cold Regions Research and Engineering Laboratory. Any opinions expressed in this paper are those of the authors, and are not to be construed as official positions of the funding agency or the Department of the Army unless so designated by other authorized documents. NR 10 TC 2 Z9 2 U1 0 U2 8 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD MAR PY 2013 VL 133 IS 3 BP EL195 EP EL201 DI 10.1121/1.4790820 PG 7 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 108NP UT WOS:000316300900008 ER PT J AU Houston, JR AF Houston, James R. TI Global Sea Level Projections to 2100 Using Methodology of the Intergovernmental Panel on Climate Change SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING LA English DT Article DE Sea level; Climates; Forecasting; Coastal environment ID GREENLAND ICE-SHEET; TIDE GAUGES; RISE; ACCELERATION; GLACIERS; 21ST-CENTURY; AUSTRALIA; CAPS AB Forecasts of sea-level rise by 2100 have such a wide range that objective planning is difficult. In 2007, the Intergovernmental Panel on Climate Change (IPCC) forecast a sea-level rise from 1990 to 2100 between 0.18 and 0.59 m, but they did not completely consider contributions from Greenland and Antarctica in determining the upper limit. Recent projections by others have been larger, typically 1-2 m, with Greenland and Antarctica being the greatest contributors. However, these projections are usually maximum possible rises without probabilities of occurrence, whereas the maximum IPCC projection is at the 95% confidence level with a 2.5% probability of being equaled or exceeded. Project planning and design generally require projections with associated probabilities to determine risk. This paper shows what worldwide tide gauge data tell us about sea-level rise trends and accelerations in the twentieth century, and satellite altimeter recordings tell us about the rise since the early 1990s. Using IPCC methodology, sea level projections with associated probabilities are made from 1990 to 2100. Projections of Greenland and Antarctica contributions are estimated based on satellite measurements of current ice-mass-loss trends and accelerations, and then they are added to contributions from thermal expansion and melting of glaciers and ice caps based on the latest information. Sea-level rise projections from 1990 to 2100 are 0.18, 0.48, and 0.82 m at 5, 50, and 95% confidence levels, respectively. DOI: 10.1061/(ASCE)WW.1943-5460.0000158. (C) 2013 American Society of Civil Engineers. C1 USA, Engineer Res & Dev Ctr, Corps Engineers, Vicksburg, MS 39180 USA. RP Houston, JR (reprint author), USA, Engineer Res & Dev Ctr, Corps Engineers, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM james.r.houston@usace.army.mil NR 48 TC 3 Z9 3 U1 6 U2 55 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-950X EI 1943-5460 J9 J WATERW PORT COAST JI J. Waterw. Port Coast. Ocean Eng. PD MAR PY 2013 VL 139 IS 2 BP 82 EP 87 DI 10.1061/(ASCE)WW.1943-5460.0000158 PG 6 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA 116GV UT WOS:000316871900002 ER PT J AU Atkinson, J Smith, JM Bender, C AF Atkinson, John Smith, Jane McKee Bender, Christopher TI Sea-Level Rise Effects on Storm Surge and Nearshore Waves on the Texas Coast: Influence of Landscape and Storm Characteristics SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING LA English DT Article DE Sea-level rise; Storm surge; Waves; Inundation; Land cover; ADCIRC; WAM; STWAVE; Texas; Hurricanes ID SOUTHERN LOUISIANA; POTENTIAL IMPACT; SUBSIDENCE; HURRICANES AB Sea-level rise (SLR) estimates vary broadly, but most estimates predict significant increases in sea levels within the next century. Through the use of validated, coupled wave and hydrodynamic models, this study investigates SLR effects on storm surge and nearshore waves, including variation with coastal landscape type and storm characteristics. Both the wave and hydrodynamic models account for bottom friction based on land-use type, so the modeling procedure accounted for SLR-related changes to land cover, in addition to higher mean sea levels. Simulation of storms with similar meteorological characteristics and track but with landfall in the northeastern and southwestern coastal areas allowed examination of how the coastal features influenced the storm surge and wave response to increased sea levels. The simulation results analyzed here demonstrate that the relationship between storm surge and relative SLR (RSLR) varies between geographic region and storm scenario. The increase in an inundated area is linear in the north, and in the south, the inundated area approaches the northern values for similar storms asymptotically. Nearshore wave results indicate, as expected, that larger water depths created by positive RSLR and amplified surge allow larger waves to propagate into inland areas. For the Texas simulations, it was found that an increase in hurricane wind speeds of 25% is approximately equivalent to a RSLR of 0.5 m in terms of increased area of inundation impact. Because of the complexities of storm-surge dependency on storm strength, track, and local topography, there is no one-size-fits-all response to RSLR descriptive of all locations. Site-specific computer modeling should be used to evaluate the risk facing coastal communities. DOI: 10.1061/(ASCE)WW.1943-5460.0000187. (C) 2013 American Society of Civil Engineers. C1 [Atkinson, John] ARCADIS US Inc, Boulder, CO 80301 USA. [Smith, Jane McKee] USA, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Corps Engineers, Vicksburg, MS 39180 USA. [Bender, Christopher] Taylor Engn Inc, Jacksonville, FL 32256 USA. RP Bender, C (reprint author), Taylor Engn Inc, 10151 Deerwood Pk Blvd,Suite 300,Bldg 300, Jacksonville, FL 32256 USA. EM john.atkinson@arcadis-us.com; Jane.M.Smith@usace.army.mil; cbender@taylorengineering.com NR 36 TC 14 Z9 14 U1 1 U2 31 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-950X J9 J WATERW PORT C JI J. Waterw. Port Coast. Ocean Eng. PD MAR PY 2013 VL 139 IS 2 BP 98 EP 117 DI 10.1061/(ASCE)WW.1943-5460.0000187 PG 20 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA 116GV UT WOS:000316871900004 ER PT J AU Flick, RE Knuuti, K Gill, SK AF Flick, Reinhard E. Knuuti, Kevin Gill, Stephen K. TI Matching Mean Sea Level Rise Projections to Local Elevation Datums SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING LA English DT Article DE Sea level; Sea level rise projections; Sea level rise scenarios; Geodetic datums; Tidal datums ID TIDES AB A method is presented to consistently tie future mean sea level rise (MSLR) scenario projections to local geodetic and tidal datums. This extends the U. S. Army Corps of Engineer (USACE) guidance for incorporating the effects of future MSLR into coastal projects. While USACE relies on the National Oceanic and Atmospheric Administration (NOAA) 19-year National Tidal Datum Epoch (NTDE) for its datum relationships, the approach proposed herein generalizes this guidance by choosing the appropriate 19-year epoch centered on the start year of the MSLR scenario under consideration. The procedure takes into account the local annual sea level variability, which confounds the matching to any given single year while generalizing and preserving the 19-year averaging long used by NOAA to calculate the NTDE. Examples of the MSLR scenario matching procedure are given using actual data and projections for La Jolla, California, and Sewells Point (Hampton Roads), Virginia. DOI: 10.1061/(ASCE)WW.1943-5460.0000145. (C) 2013 American Society of Civil Engineers. C1 [Flick, Reinhard E.] TerraCosta Consulting Grp, San Diego, CA 92123 USA. [Flick, Reinhard E.] Univ Calif San Diego, Scripps Inst Oceanog, Calif Dept Boating & Waterways, La Jolla, CA 92093 USA. [Knuuti, Kevin] USA, Corps Engineers, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Gill, Stephen K.] NOAA, Natl Ocean Serv, Ctr Operat Oceanog Prod & Serv, Silver Spring, MD 20910 USA. RP Flick, RE (reprint author), TerraCosta Consulting Grp, 3890 Murphy Canyon Rd,Suite 200, San Diego, CA 92123 USA. EM rflick@ucsd.edu FU SPAWAR Systems Center Pacific from the Strategic Environmental Research and Development Program (SERDP) [SI-1703] FX This study was conducted in collaboration with SPAWAR Systems Center Pacific under Grant No. SI-1703 from the Strategic Environmental Research and Development Program (SERDP). This paper was markedly improved owing to the constructive criticism from the three anonymous reviewers to whom the authors are grateful. The contribution of SERDP Program Manager Dr. John Hall is especially acknowledged, who asked the key question, "Sea level rise relative to what?" NR 21 TC 1 Z9 1 U1 1 U2 8 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-950X EI 1943-5460 J9 J WATERW PORT COAST JI J. Waterw. Port Coast. Ocean Eng. PD MAR PY 2013 VL 139 IS 2 BP 142 EP 146 DI 10.1061/(ASCE)WW.1943-5460.0000145 PG 5 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA 116GV UT WOS:000316871900008 ER PT J AU Pelin, M Boscolo, S Poli, M Sosa, S Tubaro, A Florio, C AF Pelin, Marco Boscolo, Sabrina Poli, Mark Sosa, Silvio Tubaro, Aurelia Florio, Chiara TI Characterization of Palytoxin Binding to HaCaT Cells Using a Monoclonal Anti-Palytoxin Antibody SO MARINE DRUGS LA English DT Article DE palytoxin; ouabain; binding; ELISA; HaCaT cells ID CARDIAC-GLYCOSIDES; PUTATIVE PALYTOXIN; MASS-SPECTROMETRY; OSTREOPSIS-OVATA; 1ST EVIDENCE; RED-CELLS; OUABAIN; ERYTHROCYTES; ANALOGS; ATPASE AB Palytoxin (PLTX) is the reference compound for a group of potent marine biotoxins, for which the molecular target is Na+/K+-ATPase. Indeed, ouabain (OUA), a potent blocker of the pump, is used to inhibit some PLTX effects in vitro. However, in an effort to explain incomplete inhibition of PLTX cytotoxicity, some studies suggest the possibility of two different binding sites on Na+/K+-ATPase. Hence, this study was performed to characterize PLTX binding to intact HaCaT keratinocytes and to investigate the ability of OUA to compete for this binding. PLTX binding to HaCaT cells was demonstrated by immunocytochemical analysis after 10 min exposure. An anti-PLTX monoclonal antibody-based ELISA showed that the binding was saturable and reversible, with a K-d of 3 x 10(-10) M. However, kinetic experiments revealed that PLTX binding dissociation was incomplete, suggesting an additional, OUA-insensitive, PLTX binding site. Competitive experiments suggested that OUA acts as a negative allosteric modulator against high PLTX concentrations (0.3-1.0 x 10(-7) M) and possibly as a non-competitive antagonist against low PLTX concentrations (0.1-3.0 x 10(-9) M). Antagonism was supported by PLTX cytotoxicity inhibition at OUA concentrations that displaced PLTX binding (1 x 10(-5) M). However, this inhibition was incomplete, supporting the existence of both OUA-sensitive and -insensitive PLTX binding sites. C1 [Pelin, Marco; Boscolo, Sabrina; Sosa, Silvio; Tubaro, Aurelia; Florio, Chiara] Univ Trieste, Dept Life Sci, I-34127 Trieste, Italy. [Poli, Mark] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21701 USA. RP Tubaro, A (reprint author), Univ Trieste, Dept Life Sci, Via A Valerio 6, I-34127 Trieste, Italy. EM marco.pelin@hotmail.it; sabribos@hotmail.com; mark.poli@us.army.mil; silvio.sosa@econ.units.it; tubaro@units.it; florioc@units.it FU Regione Friuli Venezia-Giulia, Direzione Risorse Rurali, Agroalimentari e Forestali (Progetto "Kit e biosensori di elevata sensibilta per la determinazione delle tossine di alghe nelle acque e nei prodotti ittici del Friuli Venezia Giulia-Senstox"); Italian Ministry of Education University and Research [PRIN 2009JS5YX9_002] FX This work was supported by Regione Friuli Venezia-Giulia, Direzione Risorse Rurali, Agroalimentari e Forestali (Progetto "Kit e biosensori di elevata sensibilta per la determinazione delle tossine di alghe nelle acque e nei prodotti ittici del Friuli Venezia Giulia-Senstox") and the Italian Ministry of Education University and Research (PRIN 2009JS5YX9_002). NR 37 TC 12 Z9 12 U1 0 U2 13 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1660-3397 J9 MAR DRUGS JI Mar. Drugs PD MAR PY 2013 VL 11 IS 3 BP 584 EP 598 DI 10.3390/md11030584 PG 15 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 112QP UT WOS:000316607800002 PM 23442788 ER PT J AU Olliaro, P Vaillant, M Arana, B Grogl, M Modabber, F Magill, A Lapujade, O Buffet, P Alvar, J AF Olliaro, Piero Vaillant, Michel Arana, Byron Grogl, Max Modabber, Farrokh Magill, Alan Lapujade, Olivier Buffet, Pierre Alvar, Jorge TI Methodology of Clinical Trials Aimed at Assessing Interventions for Cutaneous Leishmaniasis SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID INTENT-TO-TREAT; NON-INFERIORITY TRIALS; MEGLUMINE ANTIMONATE; TREATMENT FAILURE; PLACEBO; GUATEMALA; EQUIVALENCE; DIAGNOSIS; KETOCONAZOLE; MILTEFOSINE AB The current evidence-base for recommendations on the treatment of cutaneous leishmaniasis (CL) is generally weak. Systematic reviews have pointed to a general lack of standardization of methods for the conduct and analysis of clinical trials of CL, compounded with poor overall quality of several trials. For CL, there is a specific need for methodologies which can be applied generally, while allowing the flexibility needed to cover the diverse forms of the disease. This paper intends to provide clinical investigators with guidance for the design, conduct, analysis and report of clinical trials of treatments for CL, including the definition of measurable, reproducible and clinically-meaningful outcomes. Having unified criteria will help strengthen evidence, optimize investments, and enhance the capacity for high-quality trials. The limited resources available for CL have to be concentrated in clinical studies of excellence that meet international quality standards. C1 [Olliaro, Piero; Arana, Byron; Lapujade, Olivier] WHO Special Programme Res & Training Trop Dis WHO, UNICEF, UNDP, World Bank, Geneva, Switzerland. [Olliaro, Piero] Univ Oxford, Ctr Trop Med & Vaccinol, Nuffield Dept Med, Churchill Hosp, Oxford, England. [Vaillant, Michel] CRP Sante, Competence Ctr Methodol & Stat, Luxembourg, Grand Duchy Lux, Luxembourg. [Grogl, Max; Magill, Alan] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. [Modabber, Farrokh] DNDi, Geneva, Switzerland. [Buffet, Pierre] Univ Paris 06, UMR945, Paris, France. [Buffet, Pierre] Hop La Pitie Salpetriere, APHP, Dept Parasitol, Paris, France. [Alvar, Jorge] WHO NTD, Geneva, Switzerland. RP Olliaro, P (reprint author), WHO Special Programme Res & Training Trop Dis WHO, UNICEF, UNDP, World Bank, Geneva, Switzerland. EM olliarop@who.int NR 66 TC 19 Z9 19 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD MAR PY 2013 VL 7 IS 3 AR e2130 DI 10.1371/journal.pntd.0002130 PG 19 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 117HI UT WOS:000316943800043 PM 23556016 ER PT J AU Robins, JG Jensen, KB Jones, TA Waldron, BL Peel, MD Rigby, CW Vogel, KP Mitchell, RB Palazzo, AJ Cary, TJ AF Robins, Joseph G. Jensen, Kevin B. Jones, Thomas A. Waldron, Blair L. Peel, Michael D. Rigby, Craig W. Vogel, Kenneth P. Mitchell, Robert B. Palazzo, Antonio J. Cary, Timothy J. TI Stand Establishment and Persistence of Perennial Cool-Season Grasses in the Intermountain West and the Central and Northern Great Plains SO RANGELAND ECOLOGY & MANAGEMENT LA English DT Article DE environmental conditions; grass species; precipitation; revegetation ID RUSSIAN WILD RYEGRASS; SEMIARID RANGELANDS; TRITICEAE GRASSES; BROMUS-TECTORUM; SEEDLING VIGOR; CHEATGRASS; COMMUNITIES; VARIETIES AB The choice of plant materials is an important component of revegetation following disturbance. To determine the utility and effectiveness of various perennial grass species for revegetation on varied landscapes, a meta analysis was used to evaluate the stand establishment and persistence of 18 perennial cool-season grass species in 34 field studies in the Intermountain and Great Plains regions of the United States under monoculture conditions. Combined across the 34 studies, stand establishment values ranged from 79% to 43% and stand persistence values ranged from 70% to 0%. Intermediate wheatgrass (Thinopyrum intermedium [Host] Barkworth & D. R. Dewey), tall wheatgrass (Thinopyrum ponticum [Podp.] Z.-W. Liu & R.-C. Wang), crested wheatgrass (Agropyron spp.), Siberian wheatgrass (Agropyron fragile [Roth] P. Candargy), and meadow brome (Bromus riparius Rehmann) possessed the highest stand establishment (>= 69%). There were no significant differences among the 12 species with the largest stand persistence values. Basin wildrye (Leymus cinereus (Scribn. & Merr.) A. Love), Altai wildrye (Leymus angustus [Trin.] Pilg.), slender wheatgrass (Elymus trachycaulus [Link] Gould ex Shinners), squirreltail (Elymus spp.), and Indian ricegrass (Achnatherum hymenoides [Roem. & Schult.] Barkworth) possessed lower stand persistence (<= 32%) than the majority of the other species, and Indian ricegrass (0%) possessed the lowest stand persistence of any of the species. Correlations between environmental conditions and stand establishment and persistence showed mean annual study precipitation to have the most consistent, although moderate effect (r=similar to 0.40) for establishment and persistence. This relationship was shown by the relatively poor stand establishment and persistence of most species at sites receiving less than 310 mm of annual precipitation. These results will be a tool for land managers to make decisions concerning the importance of stand establishment, stand persistence, and annual precipitation for revegetation projects on disturbed sites. C1 [Robins, Joseph G.; Jensen, Kevin B.; Jones, Thomas A.; Waldron, Blair L.; Peel, Michael D.; Rigby, Craig W.] ARS, USDA, Forage & Range Res Lab, Logan, UT 84322 USA. [Vogel, Kenneth P.; Mitchell, Robert B.] ARS, USDA, Grain Forage & Bioenergy Res Unit, Lincoln, NE 68583 USA. [Palazzo, Antonio J.; Cary, Timothy J.] USACE Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Robins, JG (reprint author), ARS, USDA, Forage & Range Res Lab, 6300 Old Main Hill, Logan, UT 84322 USA. EM Joseph.Robins@ars.usda.gov NR 27 TC 5 Z9 6 U1 1 U2 21 PU SOC RANGE MANAGEMENT PI LAKEWOOD PA 445 UNION BLVD, STE 230, LAKEWOOD, CO 80228-1259 USA SN 1550-7424 J9 RANGELAND ECOL MANAG JI Rangel. Ecol. Manag. PD MAR PY 2013 VL 66 IS 2 BP 181 EP 190 DI 10.2111/REM-D-11-00022.1 PG 10 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA 113CE UT WOS:000316643000009 ER PT J AU Park, J Seager, TP Rao, PSC Convertino, M Linkov, I AF Park, J. Seager, T. P. Rao, P. S. C. Convertino, M. Linkov, I. TI Integrating Risk and Resilience Approaches to Catastrophe Management in Engineering Systems SO RISK ANALYSIS LA English DT Article DE Adaptive management; disaster recovery; floodplain management; resiliency ID UNCERTAINTY; LESSONS; SCIENCE; REGIME; DESIGN; FLOOD AB Recent natural and man-made catastrophes, such as the Fukushima nuclear power plant, flooding caused by Hurricane Katrina, the Deepwater Horizon oil spill, the Haiti earthquake, and the mortgage derivatives crisis, have renewed interest in the concept of resilience, especially as it relates to complex systems vulnerable to multiple or cascading failures. Although the meaning of resilience is contested in different contexts, in general resilience is understood to mean the capacity to adapt to changing conditions without catastrophic loss of form or function. In the context of engineering systems, this has sometimes been interpreted as the probability that system conditions might exceed an irrevocable tipping point. However, we argue that this approach improperly conflates resilience and risk perspectives by expressing resilience exclusively in risk terms. In contrast, we describe resilience as an emergent property of what an engineering system does, rather than a static property the system has. Therefore, resilience cannot be measured at the systems scale solely from examination of component parts. Instead, resilience is better understood as the outcome of a recursive process that includes: sensing, anticipation, learning, and adaptation. In this approach, resilience analysis can be understood as differentiable from, but complementary to, risk analysis, with important implications for the adaptive management of complex, coupled engineering systems. Management of the 2011 flooding in the Mississippi River Basin is discussed as an example of the successes and challenges of resilience-based management of complex natural systems that have been extensively altered by engineered structures. C1 [Park, J.; Rao, P. S. C.] Purdue Univ, Sch Civil Engn, W Lafayette, IN 47907 USA. [Seager, T. P.] Arizona State Univ, Ira A Fulton Sch Engn, Tempe, AZ USA. [Linkov, I.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. [Convertino, M.] Univ Florida, Dept Agr & Biol Engn, Gainesville, FL USA. RP Linkov, I (reprint author), USA Corps Engineers, 696 Virginia Rd, Concord, MA 01742 USA. EM Igor.Linkov@usace.army.mil RI yu, jian/C-1280-2009 FU Lee A. Reith Endowment at Purdue University; Environmental Quality Research Program of the U.S. Army Engineer Research and Development Center FX The authors would like to thank Dr. Martin Schultz and Paul Welle for valuable discussions. Work completed by PSCR and JP was supported by the Lee A. Reith Endowment at Purdue University. MC and IL would like to acknowledge the funding from the Environmental Quality Research Program of the U.S. Army Engineer Research and Development Center. The authors thank E. Ferguson, the manager of this program. Permission was granted by the USACE Chief of Engineers to publish this material. The views and opinions expressed in this article are those of the individual authors and not those of the U.S. Army, or other sponsor organizations. NR 64 TC 46 Z9 57 U1 13 U2 150 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0272-4332 J9 RISK ANAL JI Risk Anal. PD MAR PY 2013 VL 33 IS 3 BP 356 EP 367 DI 10.1111/j.1539-6924.2012.01885.x PG 12 WC Public, Environmental & Occupational Health; Mathematics, Interdisciplinary Applications; Social Sciences, Mathematical Methods SC Public, Environmental & Occupational Health; Mathematics; Mathematical Methods In Social Sciences GA 109BJ UT WOS:000316339800004 PM 22967095 ER PT J AU Ryan, KL AF Ryan, Kathy L. TI APS at 125: a look back at the founding of the American Physiological Society SO ADVANCES IN PHYSIOLOGY EDUCATION LA English DT Editorial Material DE history; biomedical science; research ethic; American Physiological Society AB Ryan KL. APS at 125: a look back at the founding of the American Physiological Society. Adv Physiol Educ 37: 10-14, 2013; doi:10.1152/advan.00143.2012.-Early efforts in physiological research in the United States were produced by lone investigators working in laboratories funded by their own medical practices. In Europe, however, Claude Bernard and Carl Ludwig produced a new model of scientific research laboratories funded by the state that sought to develop the pursuit of biomedical research as an occupation. American physicians such as Henry Pickering Bowditch and S. Weir Mitchell were exposed to this new "research ethic" during their international studies and brought this new perspective home to America. Along with H. Newell Martin, these men began training professional physiologists who would assume new research positions in academic institutions. In 1887, Bowditch, Mitchell, and H. Newell Martin proposed the formation of a new society for these professional physiologists, the American Physiological Society (APS). Seventeen of the original twenty-eight members met on December 30, 1887, in New York City, NY, to establish APS. From these humble beginnings, APS evolved to become a force for change in American biomedical science. C1 [Ryan, Kathy L.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Ryan, KL (reprint author), USA, Inst Surg Res, Regulatory Compliance Div, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM Kathy.ryan@amedd.army.mil NR 22 TC 1 Z9 1 U1 1 U2 1 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 1043-4046 J9 ADV PHYSIOL EDUC JI Adv. Physiol. Educ. PD MAR PY 2013 VL 37 IS 1 BP 10 EP 14 DI 10.1152/advan.00143.2012 PG 5 WC Education, Scientific Disciplines; Physiology SC Education & Educational Research; Physiology GA 103YG UT WOS:000315954800002 PM 23471243 ER PT J AU Upreti, SR Janusz, KB Schluter, WW Bichha, RP Shakya, G Biggerstaff, BJ Shrestha, MM Sedai, TR Fischer, M Gibbons, RV Shrestha, SK Hills, SL AF Upreti, Shyam Raj Janusz, Kristen B. Schluter, W. William Bichha, Ram Padarath Shakya, Geeta Biggerstaff, Brad J. Shrestha, Murari Man Sedai, Tika Ram Fischer, Marc Gibbons, Robert V. Shrestha, Sanjaya K. Hills, Susan L. TI Estimation of the Impact of a Japanese Encephalitis Immunization Program with Live, Attenuated SA 14-14-2 Vaccine in Nepal SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID KATHMANDU; VIRUS AB Wider availability of the live, attenuated SA 14-14-2 Japanese encephalitis (JE) vaccine has facilitated introduction or expansion of immunization programs in many countries. However, information on their impact is limited. In 2006, Nepal launched a JE immunization program, and by 2009, mass campaigns had been implemented in 23 districts. To describe the impact, we analyzed surveillance data from 2004 to 2009 on laboratory-confirmed JE and clinical acute encephalitis syndrome (AES) cases. The post-campaign JE incidence rate of 1.3 per 100,000 population was 72% lower than expected if no campaigns had occurred, and an estimated 891 JE cases were prevented. In addition, AES incidence was 58% lower, with an estimated 2,787 AES cases prevented, suggesting that three times as many disease cases may have been prevented than indicated by the laboratory-confirmed JE cases alone. These results provide useful information on preventable JE disease burden and the potential value of JE immunization programs. C1 [Upreti, Shyam Raj] Minist Hlth & Populat, Child Hlth Div, Kathmandu, Nepal. [Janusz, Kristen B.; Fischer, Marc; Hills, Susan L.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Arboviral Dis Branch, Ft Collins, CO 80521 USA. [Schluter, W. William; Shrestha, Murari Man; Sedai, Tika Ram] WHO, Programme Immunizat Preventable Dis, Kathmandu, Nepal. [Bichha, Ram Padarath] Kanti Childrens Hosp, Kathmandu, Nepal. [Shakya, Geeta] Natl Publ Hlth Lab, Kathmandu, Nepal. [Biggerstaff, Brad J.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Off Director, Ft Collins, CO 80521 USA. [Gibbons, Robert V.] Armed Forces Res Inst Med Sci, US Army Med Component, Bangkok 10400, Thailand. RP Hills, SL (reprint author), Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div Vector Borne Dis, Arboviral Dis Branch, 3156 Rampart Rd, Ft Collins, CO 80521 USA. EM drshyam@hotmail.com; kbjanusz@aol.com; schluterw@wpro.who.int; drrpbichha@gmail.com; geetanphl@yahoo.com; bbiggerstaff@cdc.gov; Shresthamu@searo.who.int; Sedait@searo.who.int; mfischer@cdc.gov; Robert.Gibbons@afrims.org; shresthask@afrims.org; shills@cdc.gov FU Bill & Melinda Gates Foundation through the US Centers for Disease Control and Prevention FX The Bill & Melinda Gates Foundation provided financial support for this evaluation through a grant to the US Centers for Disease Control and Prevention. NR 20 TC 11 Z9 11 U1 0 U2 6 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAR PY 2013 VL 88 IS 3 BP 464 EP 468 DI 10.4269/ajtmh.12-0196 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 106QC UT WOS:000316158800012 PM 23358643 ER PT J AU Resnik, L Adams, L Borgia, M Delikat, J Disla, R Ebner, C Walters, LS AF Resnik, Linda Adams, Laurel Borgia, Matthew Delikat, Jemy Disla, Roxanne Ebner, Christopher Walters, Lisa Smurr TI Development and Evaluation of the Activities Measure for Upper Limb Amputees SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Article DE Amputation; Disability evaluation; Psychometrics; Rehabilitation; Upper extremity ID MYOELECTRIC CONTROL; AMPUTATION; ORTHOTICS; CAPACITY; HEALTH; ARM AB Objectives: (1) To develop a measure of activities for adults with upper limb amputation: the Activities Measure for Upper Limb Amputees (AM-ULA); and (2) to conduct initial psychometric evaluation of the measure. Design: This was a cohort study where the prototype measure was administered twice within 1 week. Tests were videotaped and graded by 2 independent raters. Interrater reliability, test-retest reliability, internal consistency, and minimal detectable change were estimated. Known group validity was examined using analyses of variance comparing scores of transradial, transhumeral, and shoulder level amputees. Convergent validity was examined by correlating AM-ULA scores with dexterity tests and self-reported function. Setting: Hospital outpatient. Participants: Subjects (N = 52) with upper limb amputation. Interventions: Not applicable. Main Outcome Measures: Not applicable. Results: Intraclass correlation coefficients (ICCs) for test-retest reliability were .88 to .91. ICCs for interraterreliability were .84 to .89. Cronbach alphas were .89 to .91. The minimal detectable change at the 90% confidence interval was 3.7 points. Subjects with more distal levels of limb loss had better scores than those with more proximal levels (P<.01). The AM-ULA was moderately correlated with most dexterity tests and self-reported function. Conclusions: The AM-ULA is a new measure of activity performance for adults with upper limb amputation that considers task completion, speed, movement quality, skillfulness of prosthetic use, and independence in its rating system. It has good interrater reliability, test-retest reliability, and demonstrated known group validity. Archives of Physical Medicine and Rehabilitation 2013;94:488-94 (C) 2013 by the American Congress of Rehabilitation Medicine C1 [Resnik, Linda; Borgia, Matthew] Providence VA Med Ctr, Providence, RI 02908 USA. [Resnik, Linda] Brown Univ, Providence, RI 02912 USA. [Adams, Laurel; Delikat, Jemy] James A Haley Vet Hosp, Rehabil Res & Dev Ctr Excellence, Tampa, FL 33612 USA. [Disla, Roxanne] New York Harbor Healthcare Syst, Manhattan Vet Adm, New York, NY USA. [Ebner, Christopher; Walters, Lisa Smurr] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. RP Resnik, L (reprint author), Providence VA Med Ctr, 830 Chalkstone Ave, Providence, RI 02908 USA. EM Linda.Resnik@va.gov FU Office of Research and Development Rehabilitation Research and Development Service, Department of Veterans Affairs [A6780I] FX Supported by the Office of Research and Development Rehabilitation Research and Development Service, Department of Veterans Affairs (grant no. A6780I). NR 24 TC 7 Z9 7 U1 1 U2 13 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0003-9993 J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD MAR PY 2013 VL 94 IS 3 BP 488 EP 494 DI 10.1016/j.apmr.2012.10.004 PG 7 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 106PZ UT WOS:000316158500012 PM 23085376 ER PT J AU DeLellis, SM Anderson, SE Lynch, JH Kratz, K AF DeLellis, Stephen M. Anderson, Steven E. Lynch, James H. Kratz, Kris TI Acute Mountain Sickness Prophylaxis: A High-Altitude Perspective SO CURRENT SPORTS MEDICINE REPORTS LA English DT Review ID PLACEBO-CONTROLLED TRIAL; GINKGO-BILOBA; PULMONARY-EDEMA; PREVENTION; ILLNESS; ACETAZOLAMIDE; SILDENAFIL AB Acute mountain sickness (AMS) is the most common form of altitude illness affecting athletes and adventurists who work or play at elevations greater than 10,000 ft above mean sea level. Considerable research has been conducted to mitigate risk for those who work or play in environmental extremes. This article describes the experiences of a group of U. S. Army Special Operations soldiers who tested recommended doses of acetazolamide prophylaxis for AMS during six expeditions to elevations between 19,000 and 23,000 ft. In addition, we briefly review the literature as it pertains to prophylaxis of AMS. In our experience, prophylaxis with the recommended doses of acetazolamide resulted in fewer AMS symptoms and seemed to confer a higher likelihood of successfully summiting each peak. We conclude that acetazolamide is an acceptable choice for AMS prevention along with a slow, controlled ascent and proper fitness, nutrition, clothing, and gear. C1 [DeLellis, Stephen M.; Anderson, Steven E.; Lynch, James H.; Kratz, Kris] Womack Family Med Clin, Womack Army Med Ctr, Dept Army, Ft Bragg, NC 28310 USA. RP DeLellis, SM (reprint author), Womack Family Med Clin, Womack Army Med Ctr, Dept Army, Ft Bragg, NC 28310 USA. EM delelliss@aosa.army.mil NR 26 TC 3 Z9 4 U1 1 U2 26 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1537-890X J9 CURR SPORT MED REP JI Curr. Sport. Med. Rep. PD MAR-APR PY 2013 VL 12 IS 2 BP 110 EP 114 DI 10.1249/JSR.0b013e3182874d0f PG 5 WC Sport Sciences SC Sport Sciences GA 106DF UT WOS:000316121400013 PM 23478562 ER PT J AU Ingram, BJ Raymond, TJ AF Ingram, Benjamin J. Raymond, Tyler J. TI Recognition and Treatment of Freezing and Nonfreezing Cold Injuries SO CURRENT SPORTS MEDICINE REPORTS LA English DT Review ID SOCIETY PRACTICE GUIDELINES; SEVERE FROSTBITE; PREVENTION; CHILBLAINS; EXTREMITIES; MANAGEMENT; AMPUTATION; THERAPY; TRIAL AB This article reviews recent medical literature to provide an overview of the recognition and treatment of the two broad categories of cold injuries, freezing and nonfreezing. Frostbite, a freezing cold injury, is treated traditionally with rapid rewarming followed by tissue care and surgical debridement of necrotic tissue. Recently, newer therapies aimed at prevention of tissue necrosis have shown improved outcomes compared with more traditional therapies. These newer treatment regimens for frostbite include the use of various drugs such as ibuprofen, aspirin, warfarin, tissue plasminogen activator, and prostacyclin. The use of Tc-99m bone scans, magnetic resonance imaging arthrogram, or angiography may have prognostic value for early determination of the extent of tissue loss. The more common nonfreezing cold injuries, though less severe than frostbite, may lead to short- and long-term complications requiring treatment and are discussed also. C1 [Ingram, Benjamin J.; Raymond, Tyler J.] Womack Army Med Ctr, Ft Bragg, NC 28307 USA. RP Ingram, BJ (reprint author), Womack Army Med Ctr, 2817 Reilly Rd,Stop A, Ft Bragg, NC 28307 USA. EM Benjamin.James.Ingram@us.army.mil NR 32 TC 8 Z9 8 U1 0 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1537-890X J9 CURR SPORT MED REP JI Curr. Sport. Med. Rep. PD MAR-APR PY 2013 VL 12 IS 2 BP 125 EP 130 DI 10.1249/JSR.0b013e3182877454 PG 6 WC Sport Sciences SC Sport Sciences GA 106DF UT WOS:000316121400016 PM 23478565 ER PT J AU Sulkowski, MS Poordad, F Manns, MP Bronowicki, JP Reddy, KR Harrison, SA Afdhal, NH Sings, HL Pedicone, LD Koury, KJ Sniukiene, V Burroughs, MH Albrecht, JK Brass, CA Jacobson, IM AF Sulkowski, Mark S. Poordad, Fred Manns, Michael P. Bronowicki, Jean-Pierre Reddy, K. Rajender Harrison, Stephen A. Afdhal, Nezam H. Sings, Heather L. Pedicone, Lisa D. Koury, Kenneth J. Sniukiene, Vilma Burroughs, Margaret H. Albrecht, Janice K. Brass, Clifford A. Jacobson, Ira M. CA SPRINT-2 Trial Investigators TI Anemia during treatment with peginterferon Alfa-2b/ribavirin and boceprevir: Analysis from the serine protease inhibitor therapy 2 (SPRINT-2) trial SO HEPATOLOGY LA English DT Article ID CHRONIC HEPATITIS-C; GENOTYPE 1 INFECTION; INTERFERON-ALPHA-2B PLUS RIBAVIRIN; VIRUS-INFECTION; COMBINATION THERAPY; TELAPREVIR; ALPHA-2A AB Boceprevir (BOC) added to peginterferon alfa-2b (PegIFN) and ribavirin (RBV) significantly increases sustained virologic response (SVR) rates over PegIFN/RBV alone in previously untreated adults with chronic hepatitis C genotype 1. We evaluate the relationship of incident anemia with triple therapy. A total of 1,097 patients received a 4-week lead-in of PegIFN/RBV followed by: (1) placebo plus PegIFN/RBV for 44 weeks (PR48); (2) BOC plus PegIFN/RBV using response-guided therapy (BOC/RGT); and (3) BOC plus PegIFN/RBV for 44 weeks (BOC/PR48). The management of anemia (hemoglobin [Hb] <10 g/dL) included RBV dose reduction and/or erythropoietin (EPO) use. A total of 1,080 patients had 1 Hb measurement during treatment. The incidence of anemia was 50% in the BOC arms combined (363/726) and 31% in the PR48 arm (108/354, P < 0.001). Among BOC recipients, lower baseline Hb and creatinine clearance were associated with incident anemia. In the BOC-containing arms, anemia was managed by the site investigators as follows: EPO without RBV dose reduction, 38%; RBV dose reduction without EPO, 8%; EPO with RBV dose reduction, 40%; and neither RBV dose reduction nor EPO, 14%. SVR rates were not significantly affected by management strategy (70%-74%), and overall patients with anemia had higher rates of SVR than those who did not develop anemia (58%). Serious and life-threatening adverse events (AEs) and discontinuations due to AEs among BOC-treated patients did not differ by EPO use. Conclusion: With BOC/PR therapy, SVR rates in patients with incident anemia were higher than nonanemic patients and did not vary significantly according to the investigator-selected approach for anemia management. Prospective studies are needed to confirm this observation. (HEPATOLOGY 2013) C1 [Sulkowski, Mark S.] Johns Hopkins Univ, Sch Med, Baltimore, MD 21287 USA. [Poordad, Fred] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA. [Manns, Michael P.] Hannover Med Sch, Hannover, Germany. [Bronowicki, Jean-Pierre] Univ Lorraine, Ctr Hosp Univ Nancy, INSERM, U954, Nancy, France. [Reddy, K. Rajender] Univ Penn, Philadelphia, PA 19104 USA. [Harrison, Stephen A.] Brooke Army Med Ctr, San Antonio, TX USA. [Afdhal, Nezam H.] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. [Sings, Heather L.; Pedicone, Lisa D.; Koury, Kenneth J.; Sniukiene, Vilma; Burroughs, Margaret H.; Albrecht, Janice K.; Brass, Clifford A.] Merck Sharp & Dohme Corp, Whitehouse Stn, NJ USA. [Jacobson, Ira M.] Weill Cornell Med Coll, New York, NY USA. RP Sulkowski, MS (reprint author), Johns Hopkins Univ, Sch Med, 600 North Wolfe St,1830,Bldg,Suite 445, Baltimore, MD 21287 USA. EM msulkowski@jhmi.edu RI Bowlus, Christopher/N-9276-2016; OI Bowlus, Christopher/0000-0002-3906-6811; Vargas, Hugo/0000-0002-7802-688X FU Schering-Plough; Abbott; Bristol-Myers Squibb; BoehringerIngelheim; Gilead; Janssen; Merck; Novartis; Pfizer; Vertex; Achillion; Genentech; Salix; Idenix; Tibotec; GlaxoSmithKline FX Sponsored by Schering-Plough (now part of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Whitehouse Station, NJ).; Mark S. Sulkowski has received consultancy fees and has grants/grants pending from Abbott, Bristol-Myers Squibb, BoehringerIngelheim, Gilead, Janssen, Merck, Novartis, Pfizer, and Vertex. Fred Poordad has received consultancy fees from Merck, Vertex, Abbott, Gilead, Achillion, Genentech, and Tibotec; has grants/grants pending from Merck; and has received payment for development of educational presentations and speaker fees from Merck, Genentech, Salix, and Gilead. Michael P. Manns has received consultancy fees from Achillion, Schering-Plough (now part of Merck), Roche, Bristol-Myers Squibb, Gilead, Boehringer-Ingelheim, Novartis, Idenix, Tibotec, Vertex, GlaxoSmithKline, and Merck; has grants/grants pending from Schering-Plough (now part of Merck), Roche, Gilead, Novartis, Boehringer-Ingelheim, and Bristol-Myers Squibb; and has received payment for development of educational presentations from Schering-Plough (now part of Merck), Roche, Bristol-Myers Squibb, GlaxoSmithKline, and Gilead. Jean-Pierre Bronowicki has received consultancy fees from Schering-Plough (now part of Merck), Roche, Gilead, Bristol-Myers Squibb, Janssen, Boehringer Ingelheim, Novartis, and Bayer; payment for lectures including service on speakers bureaus for Schering-Plough (now part of Merck), Roche, Bayer, and Bristol-Myers Squibb and travel/accommodations/meeting expenses unrelated to activities listed from Roche. K. Rajender Reddy has received consultancy fees from Roche, Merck, Salix, Vertex, Tibotec, and Human Genome Science; has grants/grants pending from Roche, Vertex, Tibotec, Bristol-Myers Squibb, and Gilead; and payment for development of educational presentations from ViralEd. Stephen A. Harrison has received grant support from Merck, is an advisory board member for Merck and Vertex; has grants/grants pending from Genentech and Bristol-Myers Squibb; and has received payment for lectures, including service on speakers bureaus for Merck. Nezam H. Afdhal has received grant support from Merck, Gilead, Vertex, GSK, Abbott, BMS, and Pharmasett. He has been a scientific advisor or consultant for Gilead, Vertex, Merck, Novartis, Tibotec, Johnson and Johnson, Medgenics, and Springbank. Heather L. Sings, Kenneth Koury, and Margaret H. Burroughs are employees of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., and hold stock and/or stock options. Vilma Sniukiene, Janice K. Albrecht, Clifford A. Brass and Lisa D Pedicone are former employees of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., and hold stock and/or stock options. Ira M. Jacobson has received consultancy fees from Bristol-Myers Squibb, Novartis, Gilead, Merck, Pfizer, Vertex, GlobeImmune, Boehringer-Ingelheim, Pharmasset, Tibotec, Abbott, Roche/Genentech, and Tibotec; Achillion, and GlaxoSmithKline; has grants/grants pending from Abbott, Merck, Tibotec, Roche/Genentech, Pharmasset, Boehringer Ingelheim, Novartis, Gilead, Vertex, GlobeImmune, Human Genome Sciences, Pfizer, and Bristol-Myers Squibb; payment for lectures including service on speakers bureaus from Merck, Vertex, Gilead, Bristol-Myers Squibb, Roche/Genentech, and Vertex; and payment for development of educational presentations from Bristol-Myers Squibb, Gilead, and Vertex. NR 22 TC 47 Z9 48 U1 0 U2 18 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD MAR PY 2013 VL 57 IS 3 BP 974 EP 984 DI 10.1002/hep.26096 PG 11 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 099TG UT WOS:000315644200018 PM 23081753 ER PT J AU Veliadis, V Steiner, B Lawson, K Bayne, SB Urciuoli, D Ha, HC El-Hinnawy, N Gupta, S Borodulin, P Howell, RS Scozzie, C AF Veliadis, V. Steiner, B. Lawson, K. Bayne, S. B. Urciuoli, D. Ha, H. C. El-Hinnawy, N. Gupta, S. Borodulin, P. Howell, R. S. Scozzie, C. TI Reliable Operation of SiC JFET Subjected to Over 2.4 Million 1200-V/115-A Hard Switching Events at 150 degrees C SO IEEE ELECTRON DEVICE LETTERS LA English DT Article DE Bidirectional; fault isolation; four quadrants; hard switching; high temperature; high voltage; JFET; normally ON (N-ON); pulsing; reliability; SiC; solid-state circuit breaker (SSCB); 1200 V AB A requirement for the commercialization of power SiC transistors is their long-term reliable operation under hard switching conditions and high temperatures encountered in the field. Normally ON 1200-V vertical-channel implanted-gate SiC JFETs, designed for high-power bidirectional (four-quadrant) solid-state circuit breaker applications, were repetitively pulsed hard switched at 150 degrees C from a 1200-V blocking state to an ON-state current of 115 A, which is in excess of 13 times the JFET's 250-W/cm(2) rated current at 150 degrees C. The JFETs were fabricated in seven photolithographic levels with a single masked ion implantation forming the p(+) gates and guard rings and with no epitaxial regrowth. The pulsed testing was performed using a low-inductance RLC circuit. In this circuit, the energy initially stored in a capacitor is discharged in a load resistor through the JFET under test. The JFET hard switch stressing included over 2.4 million 1200-V/115-A hard switch events at 150 degrees C and at a repetition rate of 10 Hz. The peak energies and powers dissipated by the JFET at each hard switch event were 73.2 mJ and 68.2 kW, respectively. The current rise rate was 166 A/mu s, and the pulse FWHM was 1.8 mu s. After over 2.4 million hard switch events at 150 degrees C, the JFET blocking voltage characteristics remained unchanged while the ON-state current conduction slightly improved, which indicate reliable operation. C1 [Veliadis, V.; Ha, H. C.; El-Hinnawy, N.; Gupta, S.; Borodulin, P.; Howell, R. S.] Northrop Grumman Elect Syst, Linthicum, MD 21090 USA. [Steiner, B.; Lawson, K.; Bayne, S. B.] Texas Tech Univ, Lubbock, TX 79409 USA. [Urciuoli, D.; Scozzie, C.] USA, Res Lab, Adelphi, MD 20783 USA. RP Veliadis, V (reprint author), Northrop Grumman Elect Syst, Linthicum, MD 21090 USA. EM victor.veliadis@ngc.com FU U.S. Army Research Laboratory FX Manuscript received November 28, 2012; revised January 11, 2013; accepted January 16, 2013. Date of publication February 11, 2013; date of current version February 20, 2013. This work was supported by the U.S. Army Research Laboratory. The review of this letter was arranged by Editor C. P. Yue. NR 9 TC 10 Z9 10 U1 1 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0741-3106 EI 1558-0563 J9 IEEE ELECTR DEVICE L JI IEEE Electron Device Lett. PD MAR PY 2013 VL 34 IS 3 BP 384 EP 386 DI 10.1109/LED.2013.2241724 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA 100SP UT WOS:000315723000018 ER PT J AU Elbadry, M Sadhu, B Qiu, JX Harjani, R AF Elbadry, Mohammad Sadhu, Bodhisatwa Qiu, Joe X. Harjani, Ramesh TI Dual-Channel Injection-Locked Quadrature LO Generation for a 4-GHz Instantaneous Bandwidth Receiver at 21-GHz Center Frequency SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Article; Proceedings Paper CT IEEE Radio Frequency Integrated Circuits (RFIC) Symposium in Conjunction with the IEEE MTT-S International Microwave Symposium (IMS) / Microwave Week CY JUN 17-19, 2012 CL Montreal, CANADA SP IEEE, IEEE MTT S DE Channelized receiver; divider; injection-locked frequency divider (ILFD); injection-locked frequency multiplier (ILFM); injection locking; instantaneous wideband; multiplier injection-locked oscillator (ILO); oscillator; quadrature; quadrature voltage-controlled oscillator (QVCO); voltage-controlled oscillator (VCO) ID SPIRAL INDUCTORS; CMOS; TRANSCEIVER; AMPLITUDE; DESIGN; VCO AB This paper presents a local oscillator (LO) generation scheme for a 21-GHz center-frequency 4-GHz instantaneous bandwidth channelized receiver. A single 1.33-GHz reference source is used to simultaneously generate 20- and 22-GHz LOs with quadrature outputs. Injection locking is used instead of conventional phase-locked loop techniques allowing low-power quadrature generation. A harmonic-rich signal, containing both even and odd harmonics of the input reference signal, is generated using a digital pulse slimmer. Two injection-locked oscillator chains are used to lock on to the 10th and 11th harmonics of the reference signal generating the 20- and 22-GHz quadrature LOs, respectively. The prototype design is implemented in IBM's 130-nm CMOS process, draws 110 mA from a 1.2-V supply, and occupies an active area of 1.8 mm.(2) C1 [Elbadry, Mohammad; Sadhu, Bodhisatwa; Harjani, Ramesh] Univ Minnesota, Dept Elect & Comp Engn, Minneapolis, MN 55455 USA. [Qiu, Joe X.] USA, Res Lab, Adelphi, MD 20783 USA. RP Elbadry, M (reprint author), Univ Minnesota, Dept Elect & Comp Engn, Minneapolis, MN 55455 USA. EM elbadry@umn.edu; sadhu002@umn.edu; joe.qiu@us.army.mil; harjani@umn.edu RI Sadhu, Bodhisatwa/K-7176-2014 OI Sadhu, Bodhisatwa/0000-0002-5849-9006 NR 28 TC 6 Z9 6 U1 2 U2 11 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9480 EI 1557-9670 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD MAR PY 2013 VL 61 IS 3 SI SI BP 1186 EP 1199 DI 10.1109/TMTT.2013.2241784 PG 14 WC Engineering, Electrical & Electronic SC Engineering GA 104AM UT WOS:000315961300019 ER PT J AU Kastenmuller, K Espinosa, DA Trager, L Stoyanov, C Salazar, AM Pokalwar, S Singh, S Dutta, S Ockenhouse, CF Zavala, F Seder, RA AF Kastenmueller, Kathrin Espinosa, Diego A. Trager, Lauren Stoyanov, Cristina Salazar, Andres M. Pokalwar, Santosh Singh, Sanjay Dutta, Sheetij Ockenhouse, Christian F. Zavala, Fidel Seder, Robert A. TI Full-Length Plasmodium falciparum Circumsporozoite Protein Administered with Long-Chain Poly(I.C) or the Toll-Like Receptor 4 Agonist Glucopyranosyl Lipid Adjuvant-Stable Emulsion Elicits Potent Antibody and CD4(+) T Cell Immunity and Protection in Mice SO INFECTION AND IMMUNITY LA English DT Article ID MALARIA VACCINE RTS,S/AS02A; STRANDED-RNA POLY(I-C); MURINE MALARIA; SPOROZOITE VACCINE; CONFERS PROTECTION; GAMMA-INTERFERON; STAGE MALARIA; PHASE-3 TRIAL; CUTTING EDGE; NAIVE ADULTS AB The Plasmodium falciparum circumsporozoite (CS) protein (CSP) is a major vaccine target for preventing malaria infection. Thus, developing strong and durable antibody and T cell responses against CSP with novel immunogens and potent adjuvants may improve upon the success of current approaches. Here, we compare four distinct full-length P. falciparum CS proteins expressed in Escherichia coli or Pichia pastoris for their ability to induce immunity and protection in mice when administered with long-chain poly(I.C) [poly(I.C) LC] as an adjuvant. CS proteins expressed in E. coli induced high-titer antibody responses against the NANP repeat region and potent CSP-specific CD4(+) T cell responses. Moreover, E. coli-derived CS proteins in combination with poly(I.C) LC induced potent multifunctional (interleukin 2-positive [IL-2(+)], tumor necrosis factor alpha-positive [TNF-alpha(+)], gamma interferon-positive [IFN-gamma(+)]) CD4(+) effector T cell responses in blood, in spleen, and particularly in liver. Using transgenic Plasmodium berghei expressing the repeat region of P. falciparum CSP [Pb-CS(Pf)], we showed that there was a 1- to 4-log decrease in malaria rRNA in the liver following a high-dose challenge and similar to 50% sterilizing protection with a low-dose challenge compared to control levels. Protection was directly correlated with high-level antibody titers but not CD4(+) T cell responses. Finally, protective immunity was also induced using the Toll-like receptor 4 agonist glucopyranosyl lipid adjuvant-stable emulsion (GLA-SE) as the adjuvant, which also correlated with high antibody titers yet CD4(+) T cell immunity that was significantly less potent than that with poly(I.C) LC. Overall, these data suggest that full-length CS proteins and poly(I.C) LC or GLA-SE offer a simple vaccine formulation to be used alone or in combination with other vaccines for preventing malaria infection. C1 [Kastenmueller, Kathrin; Trager, Lauren; Stoyanov, Cristina; Seder, Robert A.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [Kastenmueller, Kathrin; Trager, Lauren; Stoyanov, Cristina; Seder, Robert A.] NIAID, Cellular Immunol Sect, NIH, Bethesda, MD 20892 USA. [Espinosa, Diego A.; Stoyanov, Cristina; Zavala, Fidel] Johns Hopkins Univ, Dept Mol Microbiol & Immunol, Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Salazar, Andres M.] Oncovir, Washington, DC USA. [Pokalwar, Santosh; Singh, Sanjay] Gennova Biopharmaceut Ltd, Pune, Maharashtra, India. [Dutta, Sheetij; Ockenhouse, Christian F.] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. [Trager, Lauren] Virginia Polytech Inst & State Univ, Virginia Maryland Reg Coll Vet Med, Blacksburg, VA 24061 USA. RP Seder, RA (reprint author), NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. EM rseder@mail.nih.gov FU MVI FX We thank MVI for funding and facilitating this comparative study by identifying and accessing the proteins and ensuring agreement of all partners on the final study design. We thank Gennova Biopharmaceuticals and WRAIR for providing the proteins CSP1 and CSP2, respectively. NR 71 TC 13 Z9 14 U1 0 U2 17 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD MAR PY 2013 VL 81 IS 3 BP 789 EP 800 DI 10.1128/IAI.01108-12 PG 12 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 108RH UT WOS:000316313200020 PM 23275094 ER PT J AU Edwards, E Belard, JL Glowa, J Khalsa, P Weber, W Huntley, K AF Edwards, Emmeline Belard, Jean Louis Glowa, John Khalsa, Partap Weber, Wendy Huntley, Kristen TI DoD-NCCAM/NIH Workshop on Acupuncture for Treatment of Acute Pain SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE LA English DT Article ID DOUBLE-BLINDED TRIAL; RANDOMIZED CONTROLLED-TRIAL; PREHOSPITAL ANALGESIA; ACUPRESSURE; COMPLEMENTARY; MEDICINE; TRAUMA; CARE; TOOL AB The Department of Defense (DoD) and the National Center for Complementary and Alternative Medicine (NCCAM) at the National Institutes of Health (NIH) cosponsored a workshop that explored the possible benefits of acupuncture treatment for acute pain. One goal of the workshop was to establish a roadmap to building an evidence base on that would indicate whether acupuncture is helpful for treating active-duty military personnel experiencing acute pain. The workshop highlighted brief presentations on the most current research on acupuncture and acute pain mechanisms. The impact of various modifiers (stress, genetics, population, phenotypes, etc.) on acute pain pathways and response to acupuncture treatment was discussed. Additional presentations focused on common neural mechanisms, an overview of real-world experience with using acupuncture to treat traumatic acute pain, and best tools and methods specific for acupuncture studies. Three breakout groups addressed the gaps, opportunities, and barriers to acupuncture use for acute pain in military and trauma settings. Different models of effectiveness research and optimal research designs for conducting trials in acute traumatic pain were also discussed. C1 [Edwards, Emmeline; Glowa, John; Khalsa, Partap; Weber, Wendy; Huntley, Kristen] NCCAM, Div Extramural Res, Bethesda, MD 20892 USA. [Belard, Jean Louis] USA, Henry M Jackson Fdn, Telemed & Adv Technol Res Ctr, MCMR TT,Med Res & Mat Command, Ft Detrick, MD USA. RP Edwards, E (reprint author), NCCAM, Div Extramural Res, Courier Serv 20817, 6707 Democracy Blvd 2,Suite 401, Bethesda, MD 20892 USA. EM edwardse@mail.nih.gov NR 36 TC 1 Z9 2 U1 0 U2 6 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1075-5535 J9 J ALTERN COMPLEM MED JI J. Altern. Complement Med. PD MAR PY 2013 VL 19 IS 3 BP 266 EP 279 DI 10.1089/acm.2012.9229.dod PG 14 WC Integrative & Complementary Medicine SC Integrative & Complementary Medicine GA 110RW UT WOS:000316464200014 PM 23020611 ER PT J AU Carlson, DW Pearson, RD Haggerty, PF Strilka, RJ Abella, BS Gourley, PE AF Carlson, Daniel W. Pearson, Ryan D. Haggerty, Paul F. Strilka, Richard J. Abella, Benjamin S. Gourley, Paul E. TI COMMOTIO CORDIS, THERAPEUTIC HYPOTHERMIA, AND EVACUATION FROM A UNITED STATES MILITARY BASE IN IRAQ SO JOURNAL OF EMERGENCY MEDICINE LA English DT Article DE commotio cordis; cardiac arrest; therapeutic hypothermia; cardiopulmonary resuscitation ID CARDIAC-ARREST; TASK-FORCE; RESUSCITATION; TRAUMA; GUIDELINES; COMMITTEE; ADULTS; DEATH AB Background: Therapeutic hypothermia (TH) has been demonstrated to improve clinical outcomes after out-of-hospital ventricular fibrillation (VF) cardiac arrest. It remains unclear if TH can be safely and effectively used in the setting of traumatic arrest. Furthermore, the use of TH methods in the pre-hospital and transport environments remain poorly established and a domain of active investigation. Objectives: To describe a case of successful TH utilization after blunt trauma with commotio cordis and pulmonary contusion, and to describe the continuation of TH during international fixed-wing aeromedical transport. Case Report: A 33-year-old active duty soldier suffered blunt chest trauma and immediate VF arrest. He was successfully resuscitated with cardiopulmonary resuscitation and defibrillation attempts. Given his ensuing comatose post-arrest state, he was therapeutically cooled and subsequently evacuated from Iraq to Germany, with cooling maintenance established in flight without the availability of training or commercial cooling equipment. The patient exhibited an eventual excellent neurologic recovery. To utilize TH for this patient, military physicians with limited local resources employed a telemedical approach to obtain a hypothermia protocol to develop a successful treatment plan. Conclusions: The patient's successful resuscitation suggests that care should not be withheld for blunt trauma patients without vital signs in the field if VF is present, until the differential diagnosis of commotio cordis has been considered. (C) 2013 Elsevier Inc. C1 [Carlson, Daniel W.] Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. [Pearson, Ryan D.] Dept Family Med, Travis AFB, CA USA. [Haggerty, Paul F.] Dept Internal Med, Wright Patterson AFB, OH USA. [Strilka, Richard J.] Royal AF Lakenheath, Brandon, Suffolk, England. [Abella, Benjamin S.] Univ Penn, Ctr Resuscitat Sci, Philadelphia, PA 19104 USA. [Gourley, Paul E.] Langley AFB, Hampton, VA USA. RP Abella, BS (reprint author), Univ Penn, Ctr Resuscitat Sci, 3400 Spruce St, Philadelphia, PA 19104 USA. OI Abella, Benjamin/0000-0003-2521-0891 FU Philips Healthcare FX Dr. Abella has received honoraria from Medivance Corporation and unrestricted research funding from Philips Healthcare. The other authors declare no relevant disclosures. NR 17 TC 2 Z9 2 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0736-4679 J9 J EMERG MED JI J. Emerg. Med. PD MAR PY 2013 VL 44 IS 3 BP 620 EP 624 DI 10.1016/j.jemermed.2012.08.014 PG 5 WC Emergency Medicine SC Emergency Medicine GA 103VF UT WOS:000315946900015 PM 23079150 ER PT J AU VanDeMark, TF Johnson, LB Pitarka, A Bennett, HH Simms, JE Yule, DE AF VanDeMark, Thomas F. Johnson, Lars B. Pitarka, Arben Bennett, Hollis H., Jr. Simms, Janet E. Yule, Don E. TI Evaluation of Seismic-Acoustic Analysis Methods for a Real-time UXO Monitoring System SO JOURNAL OF ENVIRONMENTAL AND ENGINEERING GEOPHYSICS LA English DT Article AB The Department of Defense (DoD) uses over two million rounds of high-explosive (HE) munitions per year (Defense Science Board Task Force, 2003). A small percentage does not explode, thus generating unexploded ordnance (UXO) in current range areas at a substantial rate. As these ranges are closed, the DoD becomes responsible for the environmental restoration of the affected properties. Current methods of UXO remediation are costly because of high false alarm rates. Our current research is to develop a complementary technology that will alleviate false alarm rate by detecting, classifying, and locating UXO in near real time (less than 1 minute) as a munition impacts the range. This technology will utilize an array of buried seismic sensors in a calibrated range area, along with a set of algorithms based on theoretical and applied seismology and statistical analysis. Initial field tests at three sites focused on developing concepts of the seismic and acoustic location of ordnance impacts. Our research program developed from these initial field tests has four primary objectives: 1) fully implement a wired seismic-acoustic ordnance impact location system for live fire ranges; 2) develop a system capability to discriminate high-order (HE), low-order (partially exploded), and zero-order (UXO) events; 3) reduce location error to a stringent program metric of 1-2 m; and 4) investigate the feasibility of developing a wireless implementation of the technology. This paper describes the procedures and results from follow-on tests that were conducted in two locations at the U.S. Army Aberdeen Proving Ground (APG), Maryland. These tests were used to evaluate potential seismic-acoustic methods and system configurations for a Seismic-Acoustic Impact Monitoring Assessment (SAIMA) system for mitigating UXO hazards. Significant results from this work include: 1) seismic impulses from low-order impacts were detected at distances up to 1,000 meters; 2) classification features based on measurements of the amplitude of acoustic and seismic phases produce clear discrimination between HE and UXO impacts; 3) calculated location solutions for HE and UXO impacts yield an average location error of 10-20 meters; and 4) empirical observation and waveform modeling demonstrated that surface waves dominate the signal at all distances and therefore should be the primary phase used for all components of analysis. Furthermore, these tests demonstrated the current system design, allowing further enhancements, is capable of meeting the initial research objectives (1) and (2). Future research will focus on improving system performance with refinement of the sensor-layout geometry and the detection and location algorithms through system error analyses and follow-on field testing. C1 [VanDeMark, Thomas F.; Johnson, Lars B.; Pitarka, Arben] Quantum Technol Sci Inc, Cocoa Beach, FL 32931 USA. [Bennett, Hollis H., Jr.; Simms, Janet E.; Yule, Don E.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP VanDeMark, TF (reprint author), USAF, Tech Applicat Ctr, 1030 S Highway A1A,Bldg 989, Patrick AFB, FL 32925 USA. RI pitarka, arben/K-5491-2014 NR 16 TC 1 Z9 1 U1 0 U2 10 PU ENVIRONMENTAL ENGINEERING GEOPHYSICAL SOC PI DENVER PA 1720 SOUTH BELLAIRE, STE 110, DENVER, CO 80222-433 USA SN 1083-1363 J9 J ENVIRON ENG GEOPH JI J. Environ. Eng. Geophys. PD MAR PY 2013 VL 18 IS 1 BP 71 EP 85 DI 10.2113/JEEG18.1.71 PG 15 WC Geochemistry & Geophysics; Engineering, Geological SC Geochemistry & Geophysics; Engineering GA 106RZ UT WOS:000316163700005 ER PT J AU Samberg, ME Tan, Z Monteiro-Riviere, NA Orndorff, PE Shirwaiker, RA AF Samberg, Meghan E. Tan, Zhuo Monteiro-Riviere, Nancy A. Orndorff, Paul E. Shirwaiker, Rohan A. TI Biocompatibility analysis of an electrically-activated silver-based antibacterial surface system for medical device applications SO JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE LA English DT Article ID NANOPARTICLES; INFECTION; TOXICITY; METALS; CELLS AB The costs associated with the treatment of medical device and surgical site infections are a major cause of concern in the global healthcare system. To prevent transmission of such infections, a prophylactic surface system that provides protracted release of antibacterial silver ions using low intensity direct electric current (LIDC; 28 mu A system current at 6 V) activation has been recently developed. To ensure the safety for future in vivo studies and potential clinical applications, this study assessed the biocompatibility of the LIDC-activated interdigitated silver electrodes-based surface system; in vitro toxicity to human epidermal keratinocytes, human dermal fibroblasts, and normal human osteoblasts, and antibacterial efficacy against Staphylococcus aureus and Escherichia coli was evaluated. The study concluded that the technological applications of the surface system for medical devices and surgical tools, which contact human tissues for less than 1.5 h, are expected to be self-sterilizing without causing toxicity in vivo. C1 [Samberg, Meghan E.; Monteiro-Riviere, Nancy A.] N Carolina State Univ, Ctr Chem Toxicol Res & Pharmacokinet, Raleigh, NC 27607 USA. [Samberg, Meghan E.; Tan, Zhuo; Shirwaiker, Rohan A.] Edward P Fitts Dept Ind Syst & Engn, Raleigh, NC 27695 USA. [Samberg, Meghan E.; Monteiro-Riviere, Nancy A.; Shirwaiker, Rohan A.] N Carolina State Univ, Joint Dept Biomed Engn, Raleigh, NC 27607 USA. [Samberg, Meghan E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Monteiro-Riviere, Nancy A.] Kansas State Univ, Dept Anat & Physiol, Manhattan, KS 66506 USA. [Orndorff, Paul E.] N Carolina State Univ, Dept Populat Hlth & Pathobiol, Raleigh, NC 27607 USA. RP Shirwaiker, RA (reprint author), Edward P Fitts Dept Ind Syst & Engn, 400 Daniels Hall, Raleigh, NC 27695 USA. EM rashirwaiker@ncsu.edu FU ArgentumCidalElectrics, Inc., Pittsburgh, PA; North Carolina State University's Research and Innovation Seeding Funding (RISF) Program FX The cytotoxicity evaluation experiments were supported by a research Grant from ArgentumCidalElectrics, Inc., Pittsburgh, PA. The antimicrobial efficacy testing experiments were supported by a research Grant from North Carolina State University's Research and Innovation Seeding Funding (RISF) Program. NR 23 TC 9 Z9 9 U1 0 U2 16 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0957-4530 J9 J MATER SCI-MATER M JI J. Mater. Sci.-Mater. Med. PD MAR PY 2013 VL 24 IS 3 BP 755 EP 760 DI 10.1007/s10856-012-4838-5 PG 6 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA 104TR UT WOS:000316018700018 PM 23242768 ER PT J AU Closmann, JJ Eliot, CA Foss, RD AF Closmann, James J. Eliot, Colin A. Foss, Robert D. TI Ectomesenchymal Chondromyxoid Tumor: Report of a Case With Description of Histologic and Immunohistochemical Findings SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Article ID ANTERIOR TONGUE C1 [Closmann, James J.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Eliot, Colin A.] Joint Base Pearl Harbor Hickam, Joint POW MIA Accounting Command, Cent Identificat Lab, Honolulu, HI USA. [Foss, Robert D.] USN, Dept Oral & Maxillofacial Pathol, Sch Postgrad Dent, Rockville, MD USA. RP Closmann, JJ (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM armyjawbreaker@gmail.com NR 14 TC 2 Z9 2 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD MAR PY 2013 VL 71 IS 3 BP 545 EP 549 DI 10.1016/j.joms.2012.08.003 PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 107YM UT WOS:000316256900015 PM 23043966 ER PT J AU Martini, WZ Dubick, MA Blackbourne, LH AF Martini, Wenjun Z. Dubick, Michael A. Blackbourne, Lorne H. TI Comparisons of lactated Ringer's and Hextend resuscitation on hemodynamics and coagulation following femur injury and severe hemorrhage in pigs SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article; Proceedings Paper CT 71st Annual Meeting of the American-Association-for-the-Surgery-of-Trauma CY SEP 12-15, 2012 CL Kauai, HI SP Amer Assoc Surg Trauma DE Hemorrhagic shock; Hextend; lactated Ringer's (LR) solution; thrombelastography; pig ID CARDIAC-SURGERY PATIENTS; NATURAL COLLOID RESUSCITATION; HYDROXYETHYL STARCH 130/0.4; SEVERE LIVER-INJURY; FLUID RESUSCITATION; ATTENUATES HYPERCOAGULABILITY; DILUTIONAL COAGULOPATHY; INCREASING HEMORRHAGE; REPLACEMENT THERAPY; BLOOD-COAGULATION AB BACKGROUND: This study compared coagulation function after resuscitation with Hextend and lactated Ringer's (LR) solution in pigs with tissue injury and hemorrhagic shock. METHODS: Pigs were randomized into control (n = 7 each), LR, and Hextend groups. Femur fracture was induced using the captive bolt stunner at midshaft of the pigs' left legs, followed by hemorrhage of 60% total blood volume and resuscitation with either Hextend (equal to bled volume) or LR to reach the same mean arterial pressure. Pigs in the control group were not bled or resuscitated. Hemodynamics was monitored hourly for 6 hours. Blood samples were taken at baseline (BL), after hemorrhage, 15 minutes, 3 hours, and 6 hours after resuscitation for blood and coagulation measurements. RESULTS: Mean arterial pressure decreased to 50% of BL by the 60% hemorrhage but returned to near BL within 1 hour after LR or Hextend resuscitation. Heart rate was increased (from 91 +/- 4 beats per minute to 214 +/- 20 beats per minute) by hemorrhage and decreased after resuscitation but remained elevated above BL in both groups. Resuscitation with Hextend (42 mL/kg) or LR (118 +/- 3 mL/kg) reduced hematocrit, total protein, fibrinogen, and platelet counts, with greater decreases shown in the Hextend group. Clot strengthwas lower but returned to BL by 3 hours in the LR group, whereas it remained reduced for the 6-hour period after Hextend. The overall clotting capacity after LR was decreased after hemorrhage and resuscitation but returned to BL by 3 hours, whereas it remained low after Hextend for the 6-hour experiment period. CONCLUSION: After traumatic hemorrhage, coagulation function was restored within 6 hours with LR resuscitation but not with Hextend. The lack of recovery after Hextend is likely caused by greater hemodilution and possible effects of starches on coagulation substrates and further documents the need to restrict the use of high-molecular-weight starch in resuscitation fluids for bleeding casualties. (J Trauma Acute Care Surg. 2013; 74: 732-740. Copyright (C) 2013 by Lippincott Williams & Wilkins) C1 [Martini, Wenjun Z.; Dubick, Michael A.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Martini, WZ (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM wenjun.martini@amedd.army.mil NR 42 TC 10 Z9 10 U1 2 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD MAR PY 2013 VL 74 IS 3 BP 732 EP 739 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 108UO UT WOS:000316321900006 PM 23425729 ER PT J AU Greer, LT Kuehn, RB Gillespie, DL White, PW Bell, RS Armonda, RA Fox, CJ AF Greer, Lauren T. Kuehn, Reed B. Gillespie, David L. White, Paul W. Bell, Randy S. Armonda, Rocco A. Fox, Charles J. TI Contemporary management of combat-related vertebral artery injuries SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Vascular trauma; management; vertebral artery; combat; military trauma ID BLUNT CEREBROVASCULAR INJURIES; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; ENDOVASCULAR MANAGEMENT; ARTERIOVENOUS-FISTULAS; TRAUMATIC ANEURYSMS; VASCULAR INJURY; NECK TRAUMA; DIAGNOSIS; OUTCOMES; ASSOCIATION AB BACKGROUND: Vertebral artery injuries (VAIs) following cervical trauma are uncommon. Advances in imaging technology and emerging endovascular therapies have allowed for the improved diagnosis and treatment of VAIs. We aimed to examine the contemporary management of combat-related penetrating VAIs during current US military operations. METHODS: A retrospective review was performed on US casualties with combat-related VAIs evacuated to a single military institution in the US from September 2001 to 2010 for definitive management. Casualty demographics, mechanism of injury, location and type of VAI, neurologic sequela, associated injuries, method of diagnosis, and therapeutic management were collected. RESULTS: Eleven casualties with a mean age of 26 years (mean [SD] ISS, 18 [7.0]) were found to have VAIs from gunshot wounds (6, 55%) or blast fragments (5, 45%). Cervical spine fractures (8, 72%), facial fractures (5, 45%), and spinal cord injury (3, 27%) were not uncommon. One casualty experienced a posterior cerebellar and parietal infarcts. All injuries were evaluated with digital subtraction angiography, 64-slice multidetector row computed tomography, or both. Casualties were noted to have vertebral artery occlusion (4, 36%), pseudoaneurysms (5, 45%), dissection (1, 9%), or arteriovenous fistula (1, 9%), with most injuries occurring in the V2 segment (6, 55%). Pseudoaneurysms were treated with coiling or stent-assisted coiling. Of 11 casualties, 6 were managed nonoperatively, half of whom with anticoagulation or antiplatelet therapy. CONCLUSION: VAIs are infrequent in modern combat operations, occurring in only 3% of casualties experiencing arterial injuries and are often incidentally discovered during the delayed secondary evaluation of penetrating face and neck injuries at higher echelons of care. One should have a high index of suspicious for a VAI in a casualty with concurrent cervical spine fractures. Endovascular therapies using coils and covered stents have expanded the management options and simplified the treatment of combat-related VAIs. (J Trauma Acute Care Surg. 2013;74: 818-824. Copyright (c) 2013 by Lippincott Williams & Wilkins) C1 [Greer, Lauren T.] Walter Reed Natl Mil Med Ctr, Gen Surg Serv, Bethesda, MD 20889 USA. [Bell, Randy S.; Armonda, Rocco A.] Walter Reed Natl Mil Med Ctr, Neurosurg Serv, Bethesda, MD 20889 USA. [Fox, Charles J.] Walter Reed Natl Mil Med Ctr, Vasc Surg Serv, Dept Surg, Bethesda, MD 20889 USA. [Fox, Charles J.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Div Vasc Surg, Bethesda, MD 20814 USA. [Kuehn, Reed B.] Womack Army Med Ctr, Dept Surg, Ft Bragg, NC USA. [Gillespie, David L.] Univ Rochester, Div Vasc Surg, Rochester, NY USA. [White, Paul W.] Eisenhower Army Med Ctr, Dept Vasc Surg, Augusta, GA USA. RP Fox, CJ (reprint author), Walter Reed Natl Mil Med Ctr, Div Vasc Surg, 8901 Rockville Pike, Bethesda, MD 20889 USA. EM Foxvascular@gmail.com OI Gillespie, David/0000-0002-4378-9465 FU New York Institute for Vascular Studies FX This work was supported by Dr. Frank J. Veith, MD and a grant from the New York Institute for Vascular Studies to honor military surgery and support the Walter Reed Vascular Registry. NR 40 TC 3 Z9 5 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD MAR PY 2013 VL 74 IS 3 BP 818 EP 824 DI 10.1097/TA.0b013e31827a08a8 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 108UO UT WOS:000316321900023 PM 23425741 ER PT J AU Morrison, JJ Poon, H Rasmussen, TE Khan, MA Midwinter, MJ Blackbourne, LH Garner, JP AF Morrison, Jonathan J. Poon, Henrietta Rasmussen, Todd E. Khan, Mansoor A. Midwinter, Mark J. Blackbourne, Lorne H. Garner, Jeffery P. TI Resuscitative thoracotomy following wartime injury SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article; Proceedings Paper CT 71st Annual Meeting of the American-Association-for-the-Surgery-of-Trauma CY SEP 12-15, 2012 CL Kauai, HI SP Amer Assoc Surg Trauma DE Resuscitative thoracotomy; war surgery; trauma surgery; damage-control surgery ID EMERGENCY-DEPARTMENT THORACOTOMY; TRAUMA CENTER; MORTALITY; OUTCOMES; SCORE AB BACKGROUND: The evidence for resuscitative thoracotomy (RT) in trauma patients following wartime injury is limited; its indications and timings are less defined in battle injury. The aim of this study was to analyze survival as well as the causes and times of death in patients undergoing RT within the context of modern battlefield resuscitation. METHODS: A retrospective cohort study was performed on consecutive admissions to a Field Hospital in Southern Afghanistan. All patients undergoing RT were identified using the UK Joint Theatre Trauma Registry. The primary outcome was 30-day mortality, and secondary outcomes included location of cardiac arrest, time from arrest to thoracotomy, and proportion achieving a return of spontaneous circulation. RESULTS: Between April 2006 to March 2011, 65 patients underwent RT with 14 survivors (21.5%). Ten patients (15.4%) had an arrest in the field with no survivors, 29 (44.6%) had an arrest en route with 3 survivors, and 26 (40.0%) had an arrest in the emergency department with 11 survivors. There was no difference in Injury Severity Scores (ISSs) between survivors and fatalities (27.3 [7.6] vs. 36.0 [22.1], p = 0.636). Survivors had a significantly shorter time to thoracotomy than did fatalities (6.15 [5.8] minutes vs. 17.7 [12.63] minutes, p < 0.001). CONCLUSION: RT following combat injury will yield survivors. Best outcomes are in patients who have an arrest in the emergency department or on admission to the hospital. (J Trauma Acute Care Surg. 2013;74: 825-829. Copyright (c) 2013 by Lippincott Williams & Wilkins) C1 [Morrison, Jonathan J.; Poon, Henrietta; Rasmussen, Todd E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Khan, Mansoor A.] Univ Maryland, R Adams Cowley Shock Trauma Ctr, Baltimore, MD 21201 USA. [Morrison, Jonathan J.; Khan, Mansoor A.; Midwinter, Mark J.] Royal Ctr Def Med, Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Garner, Jeffery P.] Rotterham NHS Fdn Trust, Rotterham, England. RP Morrison, JJ (reprint author), Joint Med Command, Acad Dept Mil Surg & Trauma, Royal Ctr Def Med, Vincent Dr, Birmingham B15 2SQ, AL, England. EM jjmorrison@outlook.com RI Midwinter, Mark/P-6264-2015; OI Midwinter, Mark/0000-0003-1836-7137; Morrison, Jonathan/0000-0001-7462-8456 NR 28 TC 16 Z9 17 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD MAR PY 2013 VL 74 IS 3 BP 825 EP 829 DI 10.1097/TA.0b013e31827e1d26 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 108UO UT WOS:000316321900024 PM 23425742 ER PT J AU Stannard, A Morrison, JJ Scott, DJ Ivatury, RA Ross, JD Rasmussen, TE AF Stannard, Adam Morrison, Jonathan J. Scott, Daniel J. Ivatury, Rebecca A. Ross, James D. Rasmussen, Todd E. TI The epidemiology of noncompressible torso hemorrhage in the wars in Iraq and Afghanistan SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article; Proceedings Paper CT 71st Annual Meeting of the American-Association-for-the-Surgery-of-Trauma CY SEP 12-15, 2012 CL Kauai, HI SP Amer Assoc Surg Trauma DE Wartime injury; noncompressible torso hemorrhage; vascular trauma ID COMBAT CASUALTY CARE; MAJOR LIMB TRAUMA; INJURY; MANAGEMENT; DEATH; BATTLEFIELD; MORTALITY; US AB BACKGROUND: Noncompressible torso hemorrhage (NCTH) is the leading cause of potentially survivable trauma in the battlefield and has recently been defined using anatomic and physiologic criteria. The objective of this study was to characterize the frequency and mortality in combat of NCTH using a contemporary definition. METHODS: Four categories of torso injury, each based on vascular disruption, were identified in US military casualties from the Department of Defense Trauma Registry (2002-2010): (1) thoracic, including lung; (2) solid organ (high-grade spleen, liver, and kidney); (3) named axial vessel; and (4) pelvic fracture with ring disruption. Injuries within these categories were evaluated in the context of physiologic indicator of shock and/or the need for operative hemorrhage control. RESULTS: Of 15,209 battle injuries sustained during the study period, 12.7% (n = 1,936) had sustained one or more categories of torso injury. Of these, 331 (17.1%) had evidence of shock or the need for urgent hemorrhage control, with a mean (SD) Injury Severity Score (ISS) and mortality rate of 30 (13) and 18.7%, respectively. Pulmonary injuries were most numerous (41.7%), followed by solid-organ (29.3%), vascular (25.7%), and pelvic (15.1%) injuries. Following multivariate analysis, the most mortal injury complexes were identified as major arterial injury (odds ratio, 3.38; 95% confidence interval, 1.17-9.74) and pulmonary injury (odds ratio, 2.23; 95% confidence interval, 1.23-4.98). CONCLUSION: NCTH can be defined using anatomic parameters combined with physiologic and operative interventions suggestive of hemorrhage. Major arterial and pulmonary injuries contribute most significantly to the mortality burden. (J Trauma Acute Care Surg. 2013;74: 830-834. Copyright (c) 2013 by Lippincott Williams & Wilkins) C1 [Stannard, Adam; Morrison, Jonathan J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Morrison, Jonathan J.; Scott, Daniel J.; Ivatury, Rebecca A.; Rasmussen, Todd E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Scott, Daniel J.; Ross, James D.; Rasmussen, Todd E.] Lackland AFB, Sci & Technol Sect, San Antonio, TX USA. [Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. RP Rasmussen, TE (reprint author), USA, Inst Surg Res, San Antonio, TX 78234 USA. EM todd.rasmussen@amedd.army.mil OI Morrison, Jonathan/0000-0001-7462-8456 NR 20 TC 28 Z9 29 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD MAR PY 2013 VL 74 IS 3 BP 830 EP 834 DI 10.1097/TA.0b013e31827a3704 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 108UO UT WOS:000316321900025 PM 23425743 ER PT J AU Gerlach, RC Dixon, DR Goksel, T Castle, JT Henry, WA AF Gerlach, Robert C. Dixon, Douglas R. Goksel, Tamer Castle, James T. Henry, Walter A. TI Case presentation of florid cemento-osseous dysplasia with concomitant cemento-ossifying fibroma discovered during implant explantation SO ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY LA English DT Article ID SIMPLE BONE-CYST; JAWS; FEATURES AB A 39-year-old African American woman presented for treatment of a symptomatic mandibular right first molar with a large, periapical radiolucency. After initial attempts at endodontic therapy, this tooth was ultimately extracted owing to unabated symptoms. The extraction site underwent ridge preservation grafting, implant placement, and restoration. After 26 months of implant function, the patient returned with clinical symptoms of pain, buccal swelling, and the sensation of a "loose" implant. This case report details a diagnosis of 2 distinct disease entities associated with the implant site, a cemento-ossifying fibroma and florid cemento-osseous dysplasia of the mandible. This diagnosis was determined from clinical, surgical, radiographic, and histopathologic evidence after biopsy and removal of the previously osseointegrated implant following postinsertion failure by fibrous encapsulation. Before implant therapy, it is essential to conduct a thorough radiographic evaluation of any dental arch with suspected bony lesions to prevent implant failure. (Oral Surg Oral Med Oral Pathol Oral Radiol 2013;115:e44-e52) C1 [Gerlach, Robert C.] USA, Adv Educ Program Periodont, Ft Gordon, GA 30905 USA. [Gerlach, Robert C.] USA, Adv Educ Program Oral Surg, Ft Gordon, GA 30905 USA. [Gerlach, Robert C.] USA, Adv Educ Program Oral Pathol, Ft Gordon, GA 30905 USA. [Goksel, Tamer] Oral & Maxillofacial Surg Residency Program, Ft Gordon, GA USA. [Henry, Walter A.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. RP Gerlach, RC (reprint author), USA, Adv Educ Program Periodont, Tingay Dent Clin, Bldg 278,320 E Hosp St, Ft Gordon, GA 30905 USA. EM robert.campbell.gerlach@us.army.mil NR 28 TC 2 Z9 2 U1 0 U2 9 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 2212-4403 J9 OR SURG OR MED OR PA JI Oral Surg. Oral Med. Oral Pathol. Oral Radiol. PD MAR PY 2013 VL 115 IS 3 BP E44 EP E52 DI 10.1016/j.oooo.2012.05.020 PG 9 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 109DJ UT WOS:000316345500008 PM 22858018 ER PT J AU Maynard, EE Brewer, JS AF Maynard, Erynn E. Brewer, J. Stephen TI Restoring Perennial Warm-Season Grasses as a Means of Reversing Mesophication of Oak Woodlands in Northern Mississippi SO RESTORATION ECOLOGY LA English DT Article DE Andropogon virginicus; fire; leaf litter; Schizachyrium scoparium; thinning ID PRESCRIBED FIRE; UPLAND FORESTS; REGENERATION; RESTORATION; STANDS; SITES AB Fire suppression has removed an important ecological force previously responsible for shaping many plant communities throughout the world. Upland areas of north-central Mississippi that have been protected from fire are now closed-canopy forests including species known to be uncommon as bearing/witness trees in upland portions of the landscape (historically off-site species) and sparse ground cover vegetation. Anecdotal evidence suggests that warm-season grasses were prevalent in the understory of these communities, which could have provided more consistent fuel. We corroborate the historic presence of these grasses by looking at their natural co-occurrence with oak regeneration (a requisite of self-replacing stands of oaks found historically). Restoration of these communities has typically focused on burning and off-site tree thinning. Utilizing a restoration experiment implementing these treatments, we found significantly reduced understory leaf litter in treatment areas. To test which variables associated with restoration treatments were most important for the survival of these grasses, we measured the effect of leaf litter removal and its interaction with environmental conditions on the survival of transplanted shoots. Survival of little bluestem increased with decreasing canopy density and decreasing leaf litter. Leaf-litter removal did not increase survival, nor did it interact with either pre-treatment leaf litter depth or canopy density. These results show that little bluestem benefits from conditions expected historically: increased light and possibly fire. C1 [Maynard, Erynn E.] USACE ERDC Environm Lab, Vicksburg, MS 39180 USA. [Brewer, J. Stephen] Univ Mississippi, Dept Biol, University, MS 38677 USA. RP Brewer, JS (reprint author), Univ Mississippi, Dept Biol, POB 1848, University, MS 38677 USA. EM jbrewer@olemiss.edu RI Clark, Stacy/I-3410-2015 FU U.S.D.A. Food and Agricultural Sciences National Needs Graduate and Postdoctoral Fellowship Grants Program; National Audubon Society, Inc.,; Sigma Xi Grants-in-Aid of Research Program FX The authors thank the first author's graduate thesis committee, J. Hoeksema and D. Reed, for their comments. Support was from a U.S.D.A. Food and Agricultural Sciences National Needs Graduate and Postdoctoral Fellowship Grants Program. We also received funding from the National Audubon Society, Inc., and the Sigma Xi Grants-in-Aid of Research Program. NR 34 TC 0 Z9 0 U1 3 U2 21 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1061-2971 J9 RESTOR ECOL JI Restor. Ecol. PD MAR PY 2013 VL 21 IS 2 BP 242 EP 249 DI 10.1111/j.1526-100X.2012.00871.x PG 8 WC Ecology SC Environmental Sciences & Ecology GA 105MN UT WOS:000316075000017 ER PT J AU Bruscino, T AF Bruscino, Thomas TI State of War: The Political Economy of American Warfare, 1945-2011 SO SOCIAL SCIENCE JOURNAL LA English DT Book Review C1 [Bruscino, Thomas] USA, Sch Adv Mil Studies, Ft Leavenworth, KS USA. RP Bruscino, T (reprint author), USA, Sch Adv Mil Studies, Ft Leavenworth, KS USA. EM tom.bruscino@gmail.com NR 1 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0362-3319 J9 SOC SCI J JI Soc. Sci. J. PD MAR PY 2013 VL 50 IS 1 BP 129 EP 130 DI 10.1016/j.soscij.2013.01.001 PG 2 WC Social Sciences, Interdisciplinary SC Social Sciences - Other Topics GA 110EL UT WOS:000316425300015 ER PT J AU Jensen, P Roman, J Shaft, B Wrisberg, C AF Jensen, Peter Roman, Jorge Shaft, Barrett Wrisberg, Craig TI In the Cage: MMA Fighters' Experience of Competition SO SPORT PSYCHOLOGIST LA English DT Article ID MIXED MARTIAL ARTS; TAE-KWON-DO; SELF-CONFIDENCE; SPORT; PERFORMANCE; ANXIETY; STRESS; PERCEPTIONS; PSYCHOLOGY; INJURY AB Mixed Martial Arts (MMA) is a relatively new and rapidly growing sport within contemporary athletics yet, to date, it has received relatively little attention in the sport psychology literature. To shed more light on the sport, the aim of the current study was to examine the experiences of MMA fighters during sanctioned competitions. Audio-recorded phenomenological interviews were conducted with seven participants and the transcripts were qualitatively analyzed to identify emerging themes. The findings revealed that the most important aspect of fighters' experience was the chaotic nature of MMA fights, which participants characterized as "cage reality." The results also suggested that fighters' arousal regulation skills are at least as important as their technical skills for performance success. Taken together, the present findings extend previous research on MMA and suggest several implications for sport psychology consultants interested in working with fighters. C1 [Jensen, Peter; Roman, Jorge; Shaft, Barrett; Wrisberg, Craig] Univ Tennessee, Dept Kinesiol Recreat & Sport Studies, Knoxville, TN USA. RP Jensen, P (reprint author), US Mil Acad, Ctr Enhanced Performance, West Point, NY 10996 USA. NR 48 TC 7 Z9 8 U1 2 U2 28 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 0888-4781 J9 SPORT PSYCHOL JI Sport Psychol. PD MAR PY 2013 VL 27 IS 1 BP 1 EP 12 PG 12 WC Hospitality, Leisure, Sport & Tourism; Psychology, Applied; Psychology; Sport Sciences SC Social Sciences - Other Topics; Psychology; Sport Sciences GA 111QR UT WOS:000316536300002 ER PT J AU O'Connell, RJ Gates, RG Bautista, CT Imbach, M Eggleston, JC Beardsley, SG Manak, MM Gonzales, R Rentas, FJ Macdonald, VW Cardo, LJ Reiber, DT Stramer, SL Michael, NL Peel, SA AF O'Connell, Robert J. Gates, Robert G. Bautista, Christian T. Imbach, Michelle Eggleston, John C. Beardsley, Stephen G. Manak, Mark M. Gonzales, Richard Rentas, Francisco J. Macdonald, Victor W. Cardo, Lisa J. Reiber, David T. Stramer, Susan L. Michael, Nelson L. Peel, Sheila A. TI Laboratory evaluation of rapid test kits to detect hepatitis C antibody for use in predonation screening in emergency settings SO TRANSFUSION LA English DT Article ID FRESH WHOLE-BLOOD; HUMAN-IMMUNODEFICIENCY-VIRUS; OPERATION ENDURING FREEDOM; UNITED-STATES; RESIDUAL RISK; IRAQI FREEDOM; TRANSFUSION; MILITARY; INFECTIONS; PREVALENCE AB BACKGROUND: Emergency whole blood transfusion is a lifesaving procedure employed on modern battlefields. Rapid device tests (RDTs) are frequently used to mitigate transfusion-transmitted infection risks. STUDY DESIGN AND METHODS: A limited evaluation of the RDT formerly used on battlefields was performed using 50 donor plasma samples and commercially available panels. Five hepatitisC virus (HCV) RDTs with sufficient stated sensitivity and thermostability were assessed using 335 HCV-positive and 339 HCV-negative donor plasma samples, 54 seroconversion panel plasma samples, and 84 HCV-positive and 84 HCV-negative spiked whole blood under normal, hot, and cold storage conditions and normal and hot test conditions, plus an ease-of-use survey. RESULTS: BioRapid HCV test sensitivity on donor plasma was 84% (95% confidence interval [CI], 70.9%-92.8%). Using all positive plasma samples, OraQuick HCV sensitivity exceeded all comparators (99.4%, 95% CI, 98.0%-99.9%, p<0.05). Specificity was consistently high, led by OraQuick HCV at 99.7% (95% CI, 98.6%-100%), statistically superior only to Axiom HCV (p<0.05). Using seroconversion panels, only OraQuick HCV showed equivalent or earlier HCV detection compared to the gold standard. Using spiked whole blood, specificity was consistently high, and sensitivity ranged significantly from 34.5% (95% CI, 25.0%-45.1%) for CORE HCV to 98.8% (95% CI, 94.3%-99.9%) for OraQuick HCV. All comparator RDTs were significantly less sensitive than OraQuick HCV at one or more stress condition. CONCLUSION: This HCV RDT comparison identified significant sensitivity differences, particularly using whole blood under extreme storage and testing conditions. These data support OraQuick HCV superiority and illustrate the value of RDT evaluation under simulated field conditions. C1 Walter Reed Army Inst Res, Silver Spring, MD USA. US Mil HIV Res Program, Ft Gordon, GA USA. US Army Blood Program, Falls Church, VA USA. US Army Med Dept Ctr & Sch, San Antonio, TX USA. US Armed Serv Blood Program, Falls Church, VA USA. Robertson Blood Ctr, Dept Blood Res, Ft Hood, TX USA. Amer Red Cross, Gaithersburg, MD USA. RP O'Connell, RJ (reprint author), Walter Reed Army Inst Res, Mil HIV Res Program, 6720-A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA. EM roconnell@hivresearch.org OI Manak, Mark /0000-0002-9217-9129 FU US Army Blood Program; Henry Jackson Foundation for the Advancement of Military Medicine in collaboration [W81XWH-07-2-0067]; US Army [W81XWH-07-2-0067] FX This work was supported in part by funding from the US Army Blood Program and by Cooperative Agreement W81XWH-07-2-0067 between the Henry Jackson Foundation for the Advancement of Military Medicine in collaboration and the US Army. NR 41 TC 12 Z9 12 U1 0 U2 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD MAR PY 2013 VL 53 IS 3 BP 505 EP 517 DI 10.1111/j.1537-2995.2012.03770.x PG 13 WC Hematology SC Hematology GA 104DF UT WOS:000315969500008 PM 22823283 ER PT J AU Strandenes, G Skogrand, H Spinella, PC Hervig, T Rein, EB AF Strandenes, Geir Skogrand, Hakon Spinella, Philip C. Hervig, Tor Rein, Erling B. TI Donor performance of combat readiness skills of special forces soldiers are maintained immediately after whole blood donation A study to support the development of a prehospital fresh whole blood transfusion program SO TRANSFUSION LA English DT Article ID INTENSITY CYCLE EXERCISE; MASSIVE TRANSFUSION; TRAUMA PATIENTS; CASUALTY CARE; COAGULOPATHY; SURVIVAL; INJURIES; KINETICS; IMPACT AB BACKGROUND: Bleeding is a major cause of death in combat settings, and combat casualties in shock may benefit from fresh whole blood (FWB) transfusion. Buddy transfusion is a well-known lifesaving intervention, but little is known about donor combat safety aspects immediately after blood donation. The objectives of this study were to explore the effects of donation of 1unit of blood on physical and combat-related performance among active duty soldiers. We also investigated the feasibility of a short training program to teach nonmedics buddy transfusion. STUDY DESIGN AND METHODS: Twenty-five fit male soldiers from a special forces unit were divided into three groups and tested on 1) a Bruce protocol treadmill stress test, push-ups, and pull-ups; 2) a 50-round rapid pistol shooting test; and 3) an uphill hiking exercise carrying a 20-kg backpack. After baseline testing, the soldiers performed the tests again (2-6min) after donating 450mL of blood. The training program included blood collection and reinfusion procedures and we measured success rate of venipuncture, time for blood collection, and success in placing sternal intraosseous needle and reinfusing 1 unit of autologous blood. RESULTS: We did not find any significant decrease in performance either in physical or in shooting performance after donating blood. Nonmedic soldiers had a 100% success rate in blood collection and also infusion on fellow soldiers after a short introduction to the procedures. CONCLUSION: This study supports the fact that buddy transfusion may be feasible for healthy well-trained soldiers and does not decrease donor combat performance under ideal circumstances. C1 [Strandenes, Geir] Norwegian Naval Special Operat Commando, N-5886 Bergen, Norway. Washington Univ, Dept Pediat, Div Crit Care, St Louis, MO 63130 USA. USA, Inst Surg Res, San Antonio, TX USA. Univ Bergen, Dept Immunol & Transfus Med, Haukeland Univ Hosp, Bergen, Norway. Univ Bergen, Gade Inst, Bergen, Norway. Univ Oslo, Inst Basic Med Sci, Dept Physiol, Oslo, Norway. Norwegian Army Special Operat Commando, Rena, Norway. RP Strandenes, G (reprint author), Norwegian Naval Special Operat Commando, Postboks 1 Haakonsvern, N-5886 Bergen, Norway. EM geir@docfish.no NR 19 TC 14 Z9 14 U1 1 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD MAR PY 2013 VL 53 IS 3 BP 526 EP 530 DI 10.1111/j.1537-2995.2012.03767.x PG 5 WC Hematology SC Hematology GA 104DF UT WOS:000315969500010 PM 22738468 ER PT J AU Christova, I Younan, R Taseva, E Gladnishka, T Trifonova, I Ivanova, V Spik, K Schmaljohn, C Mohareb, E AF Christova, Iva Younan, Rasha Taseva, Evgenia Gladnishka, Teodora Trifonova, Iva Ivanova, Vladislava Spik, Kristin Schmaljohn, Connie Mohareb, Emad TI Hemorrhagic Fever with Renal Syndrome and Crimean-Congo Hemorrhagic Fever as Causes of Acute Undifferentiated Febrile Illness in Bulgaria SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Hantaviruses; Crimean-Congo hemorrhagic fever virus; Acute febrile illness ID GENETIC DETECTION; DOBRAVA/BELGRADE VIRUS; HANTAVIRUS INFECTIONS; HANTAAN-VIRUS; DNA VACCINES; PUUMALA; GREECE; IMMUNOGENICITY; ALBANIA; DOBRAVA AB Hemorrhagic fever with renal syndrome (HFRS) and Crimean-Congo hemorrhagic fever (CCHF) are the 2 widespread viral hemorrhagic fevers occurring in Europe. HFRS is distributed throughout Europe, and CCHF has been reported mainly on the Balkan Peninsula and Russia. Both hemorrhagic fevers are endemic in Bulgaria. We investigated to what extent acute undifferentiated febrile illness in Bulgaria could be due to hantaviruses or to CCHF virus. Using enzyme-linked immunosorbent assays (ELISAs), we tested serum samples from 527 patients with acute febrile illness for antibodies against hantaviruses and CCHF virus. Immunoglobulin M (IgM) antibodies against hantaviruses were detected in 15 (2.8%) of the patients. Of the 15 hantavirus-positive patients, 8 (1.5%) were positive for Dobrava virus (DOBV), 5 (0.9%) were positive for Puumala virus (PUUV), and the remaining 2 were positive for both hantaviruses. A plaque reduction neutralization test (PRNT) confirmed 4 of the 10 DOBV-positive samples. PRNT was negative for all PUUV-positive samples. Serologic evidence of recent CCHF virus infection was found in 13 (2.5%) of the patients. Interestingly, HFRS and CCHF were not only detected in well-known endemic areas of Bulgaria but also in nonendemic regions. Our results suggested that in endemic countries, CCHF and/or HFRS might appear as a nonspecific febrile illness in a certain proportion of patients. Physicians must be aware of possible viral hemorrhagic fever cases, even if hemorrhages or renal impairment are not manifested. C1 [Christova, Iva; Taseva, Evgenia; Gladnishka, Teodora; Trifonova, Iva; Ivanova, Vladislava] Natl Ctr Infect & Parasit Dis, Natl Reference Tick Borne Infect Lab, Sofia 1504, Bulgaria. [Younan, Rasha; Mohareb, Emad] US Naval Med Res Unit 3 NAMRU 3, Cairo, Egypt. [Spik, Kristin; Schmaljohn, Connie] USA, Med Res Inst Infect Dis, Frederick, MD USA. RP Christova, I (reprint author), Natl Ctr Infect & Parasit Dis, Natl Reference Tick Borne Infect Lab, Blvd Yanko Sakazov 26, Sofia 1504, Bulgaria. EM iva_christova@yahoo.com FU Global Emerging Infections Surveillance Response System (GIES) funds work unit [847705.82000.25GB.E0018] FX This work was supported by the Global Emerging Infections Surveillance Response System (GIES) funds work unit # 847705.82000.25GB.E0018. This study protocol was approved by the Institute Review Board (IRB DoD# NAMRU-3.2008.003) in compliance with federal regulations governing the protection of human subjects. We are thankful to Mr. Mohamed Abdel Moemen for excellent technical assistance. NR 32 TC 6 Z9 6 U1 0 U2 3 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD MAR PY 2013 VL 13 IS 3 BP 188 EP 192 DI 10.1089/vbz.2011.0938 PG 5 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 107AH UT WOS:000316186500008 PM 23421884 ER PT J AU Hong, S Jia, S Xie, P Xu, W Leung, KP Mustoe, TA Galiano, RD AF Hong, S. Jia, S. Xie, P. Xu, W. Leung, K. P. Mustoe, T. A. Galiano, R. D. TI USE OF MESENCHYMAL STEM CELLS TO ENHANCE WOUND HEALING AND REDUCE HYPERTROPHIC SCARS SO WOUND REPAIR AND REGENERATION LA English DT Meeting Abstract C1 [Hong, S.; Jia, S.; Xie, P.; Xu, W.; Mustoe, T. A.; Galiano, R. D.] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA. [Leung, K. P.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1067-1927 J9 WOUND REPAIR REGEN JI Wound Repair Regen. PD MAR-APR PY 2013 VL 21 IS 2 BP A26 EP A26 PG 1 WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery GA 103KI UT WOS:000315914400054 ER PT J AU Cao, XY Birdwell, JE Chappell, MA Li, Y Pignatello, JJ Mao, JD AF Cao, Xiaoyan Birdwell, Justin E. Chappell, Mark A. Li, Yuan Pignatello, Joseph J. Mao, Jingdong TI Characterization of oil shale, isolated kerogen, and postpyrolysis residues using advanced C-13 solid-state nuclear magnetic resonance spectroscopy SO AAPG BULLETIN LA English DT Article ID NMR-SPECTROSCOPY; THERMAL MATURATION; HUMIC SUBSTANCES; MAS NMR; PYROLYSIS; CARBON; DEGRADATION; MATTER AB Characterization of oil shale kerogen and organic residues remaining in postpyrolysis spent shale is critical to the understanding of the oil generation process and approaches to dealing with issues related to spent shale. The chemical structure of organic matter in raw oil shale and spent shale samples was examined in this study using advanced solid-state C-13 nuclear magnetic resonance (NMR) spectroscopy. Oil shale was collected from Mahogany zone outcrops in the Piceance Basin. Five samples were analyzed: (1) raw oil shale, (2) isolated kerogen, (3) oil shale extracted with chloroform, (4) oil shale retorted in an open system at 500 degrees C to mimic surface retorting, and (5) oil shale retorted in a closed system at 360 degrees C to simulate in-situ retorting. The NMR methods applied included quantitative direct polarization with magic-angle spinning at 13 kHz, cross polarization with total sideband suppression, dipolar dephasing, CHn selection, C-13 chemical shift anisotropy filtering, and H-1-C-13 long-range recoupled dipolar dephasing. The NMR results showed that, relative to the raw oil shale, (1) bitumen extraction and kerogen isolation by demineralization removed some oxygen-containing and alkyl moieties; (2) unpyrolyzed samples had low aromatic condensation; (3) oil shale pyrolysis removed aliphatic moieties, leaving behind residues enriched in aromatic carbon; and (4) oil shale retorted in an open system at 500 degrees C contained larger aromatic clusters and more protonated aromatic moieties than oil shale retorted in a closed system at 360 degrees C, which contained more total aromatic carbon with a wide range of cluster sizes. C1 [Cao, Xiaoyan; Li, Yuan; Mao, Jingdong] Old Dominion Univ, Dept Chem & Biochem, Norfolk, VA 23529 USA. [Birdwell, Justin E.] US Geol Survey, Denver Fed Ctr, Denver, CO 80225 USA. [Chappell, Mark A.] USA, Environm Lab, Corps Engineers, Vicksburg, MS USA. [Pignatello, Joseph J.] Connecticut Agr Expt Stn, Dept Environm Sci, New Haven, CT 06504 USA. RP Cao, XY (reprint author), Old Dominion Univ, Dept Chem & Biochem, Norfolk, VA 23529 USA. EM xcao@odu.edu; jbirdwell@usgs.gov; mark.a.chappell@usace.army.mil; yxxli001@odu.edu; joseph.pignatello@ct.gov; jmao@odu.edu RI Cao, Xiaoyan/E-3492-2012; OI Cao, Xiaoyan/0000-0001-7571-6482; Birdwell, Justin/0000-0001-8263-1452 FU National Science Foundation [CBET-0853950, CBET-0853682] FX We thank the National Science Foundation (CBET-0853950 and CBET-0853682) for financial support. We also thank the following colleagues for their assistance with the various experimental aspects of this work: Mike Lewan (ISS pyrolysis experiments, kerogen isolation, and sample collection) and Ron Hill (sample collection). The results presented in the manuscript were first publicized at the 28th Annual Meeting of The Society for Organic Petrology held in Halifax, Nova Scotia, Canada, July 31 to August 4, 2011. Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. Government. NR 33 TC 9 Z9 9 U1 0 U2 50 PU AMER ASSOC PETROLEUM GEOLOGIST PI TULSA PA 1444 S BOULDER AVE, PO BOX 979, TULSA, OK 74119-3604 USA SN 0149-1423 J9 AAPG BULL JI AAPG Bull. PD MAR PY 2013 VL 97 IS 3 BP 421 EP 436 DI 10.1306/09101211189 PG 16 WC Geosciences, Multidisciplinary SC Geology GA 100ZS UT WOS:000315745100004 ER PT J AU Munger, KL Levin, LI Massa, J Horst, R Orban, T Ascherio, A AF Munger, Kassandra L. Levin, Lynn I. Massa, Jennifer Horst, Ronald Orban, Tihamer Ascherio, Alberto TI Preclinical Serum 25-Hydroxyvitamin D Levels and Risk of Type 1 Diabetes in a Cohort of US Military Personnel SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Article DE nested case-control study; type 1 diabetes; vitamin D ID REGULATORY T-CELLS; VITAMIN-D LEVELS; COD-LIVER OIL; 1,25-DIHYDROXYVITAMIN D-3; MULTIPLE-SCLEROSIS; AUTOIMMUNE-DISEASES; PANCREATIC-ISLETS; NOD MICE; PREVENTION; MELLITUS AB To determine whether serum levels of 25-hydroxyvitamin D (25(OH)D) in young adults are associated with risk of type 1 diabetes mellitus (T1D), we conducted a prospective, nested case-control study among US activeduty military personnel with serum in the US Department of Defense Serum Repository, identifying 310 T1D cases diagnosed between 1997 and 2009 with at least 2 serum samples collected before disease onset and 613 controls matched to cases on age, sex, race/ethnicity, branch of military service, and dates of serum collection. Conditional logistic regression was used to estimate rate ratios and 95% confidence intervals. Among non-Hispanic whites, those with average 25(OH)D levels of >= 100 nmol/L had a 44% lower risk of developing T1D than those with average 25(OH)D levels <75 nmol/L (rate ratio = 0.56, 95% confidence interval: 0.35, 0.90, P for trend = 0.03) over an average follow-up of 5.4 years. In quintile analyses, T1D risk was highest among individuals whose 25(OH)D levels were in the lowest 20% of those measured. There was no association between 25(OH)D levels and risk of T1D among non-Hispanic blacks or Hispanics. Low 25(OH)D levels may predispose healthy, young, non-Hispanic white adults to the development of T1D. C1 [Munger, Kassandra L.; Massa, Jennifer; Ascherio, Alberto] Harvard Univ, Harvard Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. [Levin, Lynn I.] Walter Reed Army Inst Res, Dept Epidemiol, Div Prevent Med, Silver Spring, MD USA. [Massa, Jennifer; Ascherio, Alberto] Harvard Univ, Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Horst, Ronald] Heartland Assays, Ames, IA USA. [Orban, Tihamer] Orban Biotech LLC, Boston, MA USA. [Ascherio, Alberto] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA. [Ascherio, Alberto] Harvard Univ, Harvard Med Sch, Boston, MA 02115 USA. RP Munger, KL (reprint author), Harvard Univ, Sch Publ Hlth, 665 Huntington Ave,Bldg 2,3rd Floor, Boston, MA 02115 USA. EM kgorham@hsph.harvard.edu FU National Institute of Neurological Disorders and Stroke [NS046635] FX This study was funded by the National Institute of Neurological Disorders and Stroke (grant NS046635). NR 43 TC 24 Z9 25 U1 0 U2 10 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD MAR 1 PY 2013 VL 177 IS 5 BP 411 EP 419 DI 10.1093/aje/kws243 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 100LV UT WOS:000315703600006 PM 23380046 ER PT J AU Ji, MK Kim, HC Sapireddy, VR Yun, HS Abou-Shanab, RAI Choi, J Lee, W Timmes, TC Inamuddin Jeon, BH AF Ji, Min-Kyu Kim, Hyun-Chul Sapireddy, Veer Raghavulu Yun, Hyun-Shik Abou-Shanab, Reda A. I. Choi, Jaeyoung Lee, Wontae Timmes, Thomas C. Inamuddin Jeon, Byong-Hun TI Simultaneous nutrient removal and lipid production from pretreated piggery wastewater by Chlorella vulgaris YSW-04 SO APPLIED MICROBIOLOGY AND BIOTECHNOLOGY LA English DT Article DE Piggery effluent; Microalgae; Nitrogen species; Phosphorus; Lipids; Fatty acids ID STRUVITE PRECIPITATION; SCENEDESMUS-OBLIQUUS; AZOSPIRILLUM-BRASILENSE; ANAEROBIC-DIGESTION; PHOSPHORUS REMOVAL; GROWTH; MICROALGAE; NITROGEN; PURIFICATION; EXTRACTION AB The feasibility of using a microalga Chlorella vulgaris YSW-04 was investigated for removal of nutrients from piggery wastewater effluent. The consequent lipid production by the microalga was also identified and quantitatively determined. The wastewater effluent was diluted to different concentrations ranging from 20 to 80 % of the original using either synthetic media or distilled water. The dilution effect on both lipid production and nutrient removal was evaluated, and growth rate of C. vulgaris was also monitored. Dilution of the wastewater effluent improved microalgal growth, lipid productivity, and nutrient removal. The growth rate of C. vulgaris was increased with decreased concentration of piggery wastewater in the culture media regardless of the diluent type. Lipid production was relatively higher when using synthetic media than using distilled water for dilution of wastewater. The composition of fatty acids accumulated in microalgal biomass was dependent upon both dilution ratio and diluent type. The microalga grown on a 20 % concentration of wastewater effluent diluted with distilled water was more promising for generating high-efficient biodiesel compared to the other culture conditions. The highest removal of inorganic nutrients was also achieved at the same dilution condition. Our results revealed the optimal pretreatment condition for the biodegradation of piggery wastewater with microalgae for subsequent production of high-efficient biodiesel. C1 [Ji, Min-Kyu; Sapireddy, Veer Raghavulu; Yun, Hyun-Shik; Jeon, Byong-Hun] Yonsei Univ, Dept Environm Engn, Wonju 220710, South Korea. [Kim, Hyun-Chul] Penn State Univ, Dept Civil & Environm Engn, University Pk, PA 16802 USA. [Abou-Shanab, Reda A. I.] City Sci Res & Technol Applicat, Dept Environm Biotechnol, Alexandria 21934, Egypt. [Choi, Jaeyoung] Korea Inst Sci & Technol KIST, Gangneung Inst, Kangnung 210340, South Korea. [Lee, Wontae] Kumoh Natl Inst Technol, Sch Civil & Environm Engn, Gumi 730701, South Korea. [Timmes, Thomas C.] US Mil Acad, Dept Geog & Environm Engn, West Point, NY 10996 USA. [Inamuddin] Aligarh Muslim Univ, Fac Engn & Technol, Dept Appl Chem, Aligarh 202002, Uttar Pradesh, India. RP Jeon, BH (reprint author), Yonsei Univ, Dept Environm Engn, Wonju 220710, South Korea. EM bhjeon@yonsei.ac.kr RI City for Scientific , and Research/E-6802-2017; OI Jeon, Byong-Hun/0000-0002-5478-765X; Abou-Shanab, Reda/0000-0002-3338-8094 FU Korea Institute of Energy Research; Senior Researchers program (the National Research Foundation of Korea) [2010-0026904]; Eco-Innovation project (Global-Top project) of the Korea Ministry of Environment; Brain Korea-21 (BK-21) program of the Korea Ministry of Education, Science & Technology (MEST) FX This work was supported by the Korea Institute of Energy Research, the Senior Researchers program (the National Research Foundation of Korea, 2010-0026904), the Eco-Innovation project (Global-Top project) of the Korea Ministry of Environment, and the Brain Korea-21 (BK-21) program of the Korea Ministry of Education, Science & Technology (MEST). NR 35 TC 33 Z9 36 U1 2 U2 80 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0175-7598 J9 APPL MICROBIOL BIOT JI Appl. Microbiol. Biotechnol. PD MAR PY 2013 VL 97 IS 6 BP 2701 EP 2710 DI 10.1007/s00253-012-4097-x PG 10 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 099VF UT WOS:000315650100039 PM 22569638 ER PT J AU Grandusky, JR Chen, JF Gibb, SR Mendrick, MC Moe, CG Rodak, L Garrett, GA Wraback, M Schowalter, LJ AF Grandusky, James R. Chen, Jianfeng Gibb, Shawn R. Mendrick, Mark C. Moe, Craig G. Rodak, Lee Garrett, Gregory A. Wraback, Michael Schowalter, Leo J. TI 270 nm Pseudomorphic Ultraviolet Light-Emitting Diodes with Over 60 mW Continuous Wave Output Power SO APPLIED PHYSICS EXPRESS LA English DT Article ID ALN AB In this letter, the achievement of over 60 mW output power from pseudomorphic ultraviolet light-emitting diodes in continuous wave operation is reported. Die thinning and encapsulation improved the photon extraction efficiency to over 15%. Improved thermal management and a high characteristic temperature resulted in a low thermal rolloff up to 300 mA injection current with an output power of 67 mW, an external quantum efficiency (EQE) of 4.9%, and a wall plug efficiency (WPE) of 2.5% for a single-chip device emitting at 271 nm in continuous wave operation. (C) 2013 The Japan Society of Applied Physics C1 [Grandusky, James R.; Chen, Jianfeng; Gibb, Shawn R.; Mendrick, Mark C.; Moe, Craig G.; Schowalter, Leo J.] Crystal IS Inc, Green Isl, NY 12183 USA. [Rodak, Lee; Garrett, Gregory A.; Wraback, Michael] USA, Res Lab, RDRL SEE M, Adelphi, MD 20783 USA. RP Grandusky, JR (reprint author), Crystal IS Inc, 70 Cohoes Ave, Green Isl, NY 12183 USA. EM grandusky@crystal-is.com FU Defense Advanced Research Projects Agency (DARPA); Army Research Laboratory (ARL) [W911NF-09-2-0068] FX This material is based on work partially supported by the Defense Advanced Research Projects Agency (DARPA) under the Compact Mid-Ultraviolet Technology program and a Cooperative Agreement (Number W911NF-09-2-0068) with the Army Research Laboratory (ARL). NR 12 TC 50 Z9 51 U1 7 U2 43 PU JAPAN SOC APPLIED PHYSICS PI TOKYO PA KUDAN-KITA BUILDING 5TH FLOOR, 1-12-3 KUDAN-KITA, CHIYODA-KU, TOKYO, 102-0073, JAPAN SN 1882-0778 J9 APPL PHYS EXPRESS JI Appl. Phys. Express PD MAR PY 2013 VL 6 IS 3 AR 032101 DI 10.7567/APEX.6.032101 PG 3 WC Physics, Applied SC Physics GA 103SB UT WOS:000315938100003 ER PT J AU Dzialowski, AR Bonneau, JL Gemeinhardt, TR AF Dzialowski, Andrew R. Bonneau, Joseph L. Gemeinhardt, Todd R. TI Comparisons of zooplankton and phytoplankton in created shallow water habitats of the lower Missouri River: implications for native fish SO AQUATIC ECOLOGY LA English DT Article DE Backwater; Chute; River restoration; Great rivers; Shallow water habitat ID FLOW REGULATION; FLOODPLAIN RIVER; LOWLAND RIVER; MAIN CHANNEL; DYNAMICS; COMMUNITY; CONNECTIVITY; IMPOUNDMENTS; ECOSYSTEMS; ABUNDANCE AB Shallow water habitat (SWH) is important for riverine fish and their invertebrate prey, yet the availability of SWH has declined in many systems due to human impacts. We evaluated the potential ecological benefits of restoring SWH by comparing zooplankton and phytoplankton from created backwaters (a floodplain feature connected to the river on the downstream end but disconnected at the upstream end) and chutes (a side channel of the river that diverts flow from the main channel through the chute and back into the main channel) on the lower Missouri River. We tested the hypothesis that backwaters support higher abundances of zooplankton and phytoplankton than chutes using data that were collected during the summer of 2010. As predicted, backwaters had more diverse cladoceran communities and greater abundances of rotifers, copepod nauplii, adult copepods, and cladocerans than chutes. Total algal biovolume was the same in chutes and backwaters; however, phytoplankton taxa richness was higher in backwaters, and there was a greater biovolume of green algae (Chlorophyta), Crypotophyta, cyanobacteria, and Euglenophyta in backwaters than in chutes. Differences in zooplankton and phytoplankton between backwaters and chutes appeared to be related to slower current velocities, longer retention times, and lower levels of turbidity and total suspended solids in backwaters. While chutes have the potential to provide greater habitat diversity than the mainstem, there were no differences in water quality or phytoplankton abundance, community structure, or diversity between these two habitats. Combined, our results suggest that created backwaters initially provide a greater potential food resource for native fishes. However, additional research is needed to determine whether chutes can also develop beneficial shallow water features over a longer period of time. C1 [Dzialowski, Andrew R.] Oklahoma State Univ, Dept Zool, Stillwater, OK 74074 USA. [Bonneau, Joseph L.] US Army Corps Engineers, Threatened & Endangered Species Sect, Yankton, SD USA. [Gemeinhardt, Todd R.] US Army Corps Engineers, Environm Resources Sect, Kansas City, MO 64106 USA. RP Dzialowski, AR (reprint author), Oklahoma State Univ, Dept Zool, Stillwater, OK 74074 USA. EM andy.dzialowski@okstate.edu; Joseph.L.Bonneau@usace.army.mil; Todd.R.Gemeinhardt@usace.army.mil NR 55 TC 3 Z9 3 U1 5 U2 47 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1386-2588 EI 1573-5125 J9 AQUAT ECOL JI Aquat. Ecol. PD MAR PY 2013 VL 47 IS 1 BP 13 EP 24 DI 10.1007/s10452-012-9421-0 PG 12 WC Ecology; Limnology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA 104QM UT WOS:000316009500002 ER PT J AU Keshtpoor, M Puleo, JA Gebert, J Plant, NG AF Keshtpoor, Mohammad Puleo, Jack A. Gebert, Jeffrey Plant, Nathaniel G. TI Beach response to a fixed sand bypassing system SO COASTAL ENGINEERING LA English DT Article ID ORTHOGONAL FUNCTION-ANALYSIS; SEDIMENT TRANSPORT; SHORELINE VARIABILITY; DOWNDRIFT EROSION; INLET; EVOLUTION AB Indian River Inlet is located at roughly the mid-point of the Atlantic coast of Delaware and connects the ocean to two Delaware inland bays. jetties constructed in 1940 have maintained the inlet for navigation purposes but have also acted as a barrier to net northerly alongshore sediment transport causing downdrift erosion. A mobile, land-based bypassing system was initiated in 1990 in an effort to counteract this erosion. Beach profile data from 1985 (pre-bypassing) until 2008 are used to investigate the effect of the sand bypassing system on beaches adjacent to the inlet. The downdrift beach experienced horizontal shoreline erosion between 10 and 60 m during the pre-bypassing period but accreted 10-20 m during the bypassing period. The mean shoreline location on the updrift beach during bypassing is 10-20 m landward (erosion) of its position during the pre-bypassing period. Empirical orthogonal function (EOF) amplitudes from analyses performed on mean-removed elevation surfaces during the periods of highest bypassed volume (average of 83% of design rate) showed that the influence of the bypassing system on the downdrift beach extends to about 1500 m of the inlet. An EOF analysis showed that different morphologic responses were evident following the initiation of bypass operations. Temporal variations of shoreline and beach morphology were correlated to the temporal variations in bypassing rates on the downdrift beach only. The downdrift beach response was greatest near the inlet for larger bypassing volumes. Correlation in these instances occurred with a roughly 1-year time lag suggesting that the beach quickly redistributes the bypassed sand. EOF amplitude and shoreline response are weakly correlated to bypassed volumes when the system bypassed smaller volumes (average of 56% of design rate) of sand suggesting that there is a minimum bypassing rate, regardless of yearly variability, below which the effect on the downdrift beach is obscured. (C) 2012 Elsevier B.V. All rights reserved. C1 [Keshtpoor, Mohammad; Puleo, Jack A.] Univ Delaware, Ctr Appl Coastal Res, Dept Civil & Environm Engn, Newark, DE 19716 USA. [Gebert, Jeffrey] USA, Corps Engineers, Coastal Planning Sect, Philadelphia, PA 19107 USA. [Plant, Nathaniel G.] US Geol Survey, St Petersburg Coastal & Marine Sci Ctr, St Petersburg, FL 33701 USA. RP Keshtpoor, M (reprint author), Univ Delaware, Ctr Appl Coastal Res, Dept Civil & Environm Engn, Newark, DE 19716 USA. EM mkesht@udel.edu; jpuleo@udel.edu; Jeffrey.A.Gebert@usace.army.mil; nplant@usgs.gov OI Plant, Nathaniel/0000-0002-5703-5672 FU Delaware Department of Transportation, Delaware Department of Natural Resources and Environmental Control; University of Delaware; National Oceanic and Atmospheric Administration US Department of Commerce [R/ETE-14] FX This work was funded by the Delaware Department of Transportation, Delaware Department of Natural Resources and Environmental Control and the University of Delaware. Additional funds were provided by the National Oceanic and Atmospheric Administration US Department of Commerce under award number R/ETE-14. The statements, findings, conclusions, and recommendations are those of the author(s) and do not necessarily reflect the views of the National Oceanic and Atmospheric Administration or the Department of Commerce. We thank two reviewers that provided detailed comments to improve the clarity of this paper. NR 53 TC 4 Z9 4 U1 2 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3839 J9 COAST ENG JI Coast. Eng. PD MAR PY 2013 VL 73 BP 28 EP 42 DI 10.1016/j.coastaleng.2012.09.006 PG 15 WC Engineering, Civil; Engineering, Ocean SC Engineering GA 099IO UT WOS:000315614900004 ER PT J AU Bender, C Smith, JM Kennedy, A Jensen, R AF Bender, Christopher Smith, Jane McKee Kennedy, Andrew Jensen, Robert TI STWAVE simulation of Hurricane Ike: Model results and comparison to data SO COASTAL ENGINEERING LA English DT Article DE Waves; Hurricanes; Wave measurement; Bottom friction AB Hurricane Ike (2008), with its associated storm surge, caused extensive damage across parts of the northwestern Gulf Coast when it made landfall in the late hours of September 12, 2008 along the upper Texas coast at the upper end of Category 2 intensity. An extensive instrumentation effort allowed the collection of both nearshore and inland wave and water level data as Hurricane Ike passed the Louisiana coast and made landfall in Texas. This article presents the results of a validation effort for the STWAVE model and the bottom friction coefficients applied in the model with comparisons to the Hurricane Ike measured wave data. Examination of STWAVE model results as contour plots and time series of wave height and period; wave spectra at selected time steps and scatter plots of simulated versus modeled wave results allow evaluation of the model performance. STWAVE model results indicate good agreement with the measured nearshore wave data for an open water Manning 'n' bottom friction coefficient equal to 0.03 s/m(0.33). STWAVE model results indicate good agreement with the measured inshore wave data with Manning bottom friction coefficients equal to values derived from land classification data and applied in the ADCIRC model. (C) 2012 Elsevier B.V. All rights reserved. C1 [Bender, Christopher] Taylor Engn Inc, Jacksonville, FL 32259 USA. [Smith, Jane McKee; Jensen, Robert] Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. [Kennedy, Andrew] Univ Notre Dame, Dept Civil Engn & Geol Sci, South Bend, IN 46556 USA. RP Bender, C (reprint author), Taylor Engn Inc, 10510 Deerwood Pk Blvd,Bldg 300,Suite 300, Jacksonville, FL 32259 USA. EM cbender@taylorengineering.com; Jane.M.Smith@usace.army.mil; andrew.kennedy@nd.edu; Robert.E.Jensen@usace.army.mil RI Kennedy, Andrew/E-4746-2011 OI Kennedy, Andrew/0000-0002-7254-1346 FU Flood and Coastal Systems RD Program FX Permission to publish this work was granted by the Chief of Engineers, U.S. Army Corps of Engineers. Partial support was provided by the Flood and Coastal Systems R&D Program. The Notre Dame-University of Florida team members Uriah Gravois and Brian Zachry are acknowledged for collection and analysis of the ND-UF Hurricane Ike data. NR 20 TC 4 Z9 4 U1 0 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3839 J9 COAST ENG JI Coast. Eng. PD MAR PY 2013 VL 73 BP 58 EP 70 DI 10.1016/j.coastaleng.2012.10.003 PG 13 WC Engineering, Civil; Engineering, Ocean SC Engineering GA 099IO UT WOS:000315614900006 ER PT J AU Chesnut, G Taylor, S Belin, E AF Chesnut, Gregory Taylor, Sarah Belin, Eric TI What Is Your Diagnosis? SO CUTIS LA English DT Editorial Material ID MEES LINES; CHEMOTHERAPY C1 Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Taylor, Sarah] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. [Belin, Eric] Natl Naval Ctr, Bethesda, MD USA. RP Taylor, S (reprint author), 428 Southwest Dr, Silver Spring, MD 20901 USA. EM sktaylor1@yahoo.com NR 5 TC 0 Z9 0 U1 0 U2 0 PU QUADRANT HEALTHCOM INC PI PARSIPPANY PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA SN 0011-4162 J9 CUTIS JI Cutis PD MAR PY 2013 VL 91 IS 3 BP 147 EP + PG 3 WC Dermatology SC Dermatology GA 105AQ UT WOS:000316038400011 PM 23617087 ER PT J AU Knapik, JJ Harman, EA AF Knapik, Joseph J. Harman, Everett A. TI Untitled Reply SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Letter C1 [Knapik, Joseph J.] USA, Inst Publ Hlth, Injury Prevent Program, Aberdeen Proving Ground, MD USA. RP Knapik, JJ (reprint author), USA, Inst Publ Hlth, Injury Prevent Program, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1064-8011 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD MAR PY 2013 VL 27 IS 3 BP E1 EP E2 DI 10.1097/01.JSC.0000428152.41604.df PG 3 WC Sport Sciences SC Sport Sciences GA 099CI UT WOS:000315596500002 PM 23565543 ER PT J AU Taflanidis, AA Jia, GF Kennedy, AB Smith, JM AF Taflanidis, Alexandros A. Jia, Gaofeng Kennedy, Andrew B. Smith, Jane M. TI Implementation/optimization of moving least squares response surfaces for approximation of hurricane/storm surge and wave responses SO NATURAL HAZARDS LA English DT Article DE Hurricane wave and surge; Coastal hazard; Storm surge; Tropical cyclones; Response surface approximations; Surrogate modelling optimization; Risk assessment ID HAZARD; OPTIMIZATION AB One of the important recent advances in the field of hurricane/storm modelling has been the development of high-fidelity numerical simulation models for reliable and accurate prediction of wave and surge responses. The computational cost associated with these models has simultaneously created an incentive for researchers to investigate surrogate modelling (i.e. metamodeling) and interpolation/regression methodologies to efficiently approximate hurricane/storm responses exploiting existing databases of high-fidelity simulations. Moving least squares (MLS) response surfaces were recently proposed as such an approximation methodology, providing the ability to efficiently describe different responses of interest (such as surge and wave heights) in a large coastal region that may involve thousands of points for which the hurricane impact needs to be estimated. This paper discusses further implementation details and focuses on optimization characteristics of this surrogate modelling approach. The approximation of different response characteristics is considered, and special attention is given to predicting the storm surge for inland locations, for which the possibility of the location remaining dry needs to be additionally addressed. The optimal selection of the basis functions for the response surface and of the parameters of the MLS character of the approximation is discussed in detail, and the impact of the number of high-fidelity simulations informing the surrogate model is also investigated. Different normalizations of the response as well as choices for the objective function for the optimization problem are considered, and their impact on the accuracy of the resultant (under these choices) surrogate model is examined. Details for implementation of the methodology for efficient coastal risk assessment are reviewed, and the influence in the analysis of the model prediction error introduced through the surrogate modelling is discussed. A case study is provided, utilizing a recently developed database of high-fidelity simulations for the Hawaiian Islands. C1 [Taflanidis, Alexandros A.; Jia, Gaofeng; Kennedy, Andrew B.] Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, Notre Dame, IN 46556 USA. [Smith, Jane M.] USA, Corps Engineers, Ctr Res & Dev, Vicksburg, MS 39180 USA. RP Taflanidis, AA (reprint author), Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, 156 Fitzpatrick Hall, Notre Dame, IN 46556 USA. EM a.taflanidis@nd.edu RI Kennedy, Andrew/E-4746-2011; Jia, Gaofeng/M-8369-2014; OI Kennedy, Andrew/0000-0002-7254-1346; Jia, Gaofeng/0000-0001-9419-8481; Taflanidis, Alexandros/0000-0002-9784-7480 FU US Army Corps of Engineering [W912HZ-09-C-0086] FX This research effort is partially supported by US Army Corps of Engineering grant W912HZ-09-C-0086 under the Surge and Wave Island Modeling Studies, Coastal Field Data Collection Program. This support is greatly appreciated. Permission to publish this work was granted by the Chief of Engineers, US Army Corps of Engineers. Also the contribution of Professor Joannes Westerink and graduate student Mark Hope, both at the University of Notre Dame, in developing and performing the high-fidelity simulations for the illustrative example is greatly appreciated. NR 32 TC 4 Z9 4 U1 1 U2 15 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0921-030X EI 1573-0840 J9 NAT HAZARDS JI Nat. Hazards PD MAR PY 2013 VL 66 IS 2 BP 955 EP 983 DI 10.1007/s11069-012-0520-y PG 29 WC Geosciences, Multidisciplinary; Meteorology & Atmospheric Sciences; Water Resources SC Geology; Meteorology & Atmospheric Sciences; Water Resources GA 093BG UT WOS:000315166100043 ER PT J AU Agazio, J Coe, TR Goodman, P McNeil, P Nayback, A Padden, D Steffan, N Throop, M AF Agazio, Janice Coe, Thomas Ray Goodman, Petra McNeil, Peggy Nayback, Ann Padden, Diane Steffan, Nancy Throop, Meryia TI Management of Ethical Issues by Military Nurses in Wartime SO NURSING RESEARCH LA English DT Meeting Abstract C1 [Agazio, Janice; Steffan, Nancy] Catholic Univ Amer, Washington, DC 20064 USA. [Goodman, Petra; McNeil, Peggy; Throop, Meryia] Walter Reed Natl Mil Med Ctr, Silver Spring, MD USA. [Nayback, Ann] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Padden, Diane] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-6562 J9 NURS RES JI Nurs. Res. PD MAR-APR PY 2013 VL 62 IS 2 BP E15 EP E15 PG 1 WC Nursing SC Nursing GA 103WX UT WOS:000315951300042 ER PT J AU Altieri, M Jindal, TR Patel, M Oliver, DK Falta, EM Elster, EA Doyle, A Guy, SR Womble, AL Jindal, RM AF Altieri, Maria Jindal, Tarun R. Patel, Mayur Oliver, David K. Falta, Edward M. Elster, Eric A. Doyle, Alden Guy, Stephen R. Womble, Arthur L. Jindal, Rahul M. TI REPORT OF THE FIRST PERITONEAL DIALYSIS PROGRAM IN GUYANA, SOUTH AMERICA SO PERITONEAL DIALYSIS INTERNATIONAL LA English DT Article DE Developing countries; Guyana; South America; outcomes; infection; kidney transplantation; logistics of peritoneal dialysis; supply of dialysis fluids ID CHRONIC KIDNEY-DISEASE; STAGE RENAL-DISEASE; HEMODIALYSIS; SURVIVAL; COST; MORTALITY; MODALITY; WORLD; CARE AB Introduction: In 2008, we initiated the first Guyanese comprehensive kidney replacement program, comprising hemodialysis (HD), peritoneal dialysis (PD), vascular access procedures, and living-donor kidney transplantation. The government of Guyana, US-based philanthropists, US-based physicians, and Guyanese caregivers teamed up to form a public-private partnership. This pilot program was free of cost to the patients. Methods: From July 2010 to the time of writing, we placed 17 patients with end-stage kidney disease on PD, which was used as a bridge to living-donor kidney transplantation. During the same period, we placed 12 primary arteriovenous fistulae. Results: The 17 patients who received a PD catheter had a mean age of 43.6 years and a mean follow-up of 5.3 months. In that group, 2 deaths occurred (from multi-organ failure) within 2 weeks of catheter placement, and 2 patients were switched to HD because of inadequate clearance. Technical issues were noted in 2 patients, and 3 patients developed peritonitis (treated with intravenous antibiotics). An exit-site abscess in 1 patient was drained under local anesthesia. The peritonitis rate was 0.36 episodes per patient-year. Of the 17 patients who received PD, 4 underwent living-donor kidney transplantation. Conclusions: In Guyana, PD is a safe and cost-effective option; it may be equally suitable for similar developing countries. In Guyana, PD was used as a bridge to living-donor kidney transplantation. We have been able to sustain this program since 2008 by making incremental gains and nurturing the ongoing public-private partnership. Perit Dial Int 2013; 33(2): 116-123 www.PDIConnect.com doi:10.3747/pdi.2012.00001 C1 [Altieri, Maria] Stony Brook Univ Hosp, Long Isl City, NY USA. [Jindal, Tarun R.] Indiana Univ Sch Med, Indianapolis, IL USA. [Patel, Mayur] Rutgers State Univ, Piscataway, NJ 08855 USA. [Oliver, David K.; Falta, Edward M.; Elster, Eric A.; Jindal, Rahul M.] Uniformed Serv Univ Hlth Sci, Bethesda, MD USA. [Doyle, Alden; Guy, Stephen R.] Drexel Univ, Sch Med, Philadelphia, PA 19104 USA. [Falta, Edward M.; Elster, Eric A.; Jindal, Rahul M.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. [Womble, Arthur L.] Southeastern Pain Management, Gadsden, AL USA. [Womble, Arthur L.] US Army Reserve, Med Brigade 5, Birmingham, AL USA. [Jindal, Rahul M.] George Washington Univ, Washington, DC USA. RP Jindal, RM (reprint author), Walter Reed NMMC, Dept Transplantat, Bethesda, MD USA. EM jindalr@msn.com FU Zara Realty, Queens, New York FX The authors thank Mr. George Subraj, philanthropist and president of Zara Realty (http://www.zararealty.com), Queens, New York, who funded the program; the Government of Guyana for the use of hospital space and medications; the staff of Balwant Singh Hospital, Georgetown, Guyana, where transplantation and related surgeries are performed; the department of Pathology at Drexel University, Philadelphia, and the Immunology Laboratory at Walter Reed National Military Medical Center. NR 28 TC 0 Z9 0 U1 0 U2 3 PU MULTIMED INC PI TORONTO PA 66 MARTIN ST, TORONTO, ON L9T 2R2, CANADA SN 0896-8608 J9 PERITON DIALYSIS INT JI Perit. Dial. Int. PD MAR-APR PY 2013 VL 33 IS 2 BP 116 EP 123 DI 10.3747/pdi.2012.00001 PG 8 WC Urology & Nephrology SC Urology & Nephrology GA 104LR UT WOS:000315995000003 PM 23478372 ER PT J AU Cheuvront, SN Kenefick, RW Charkoudian, N Sawka, MN AF Cheuvront, Samuel N. Kenefick, Robert W. Charkoudian, Nisha Sawka, Michael N. TI Physiologic basis for understanding quantitative dehydration assessment SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article ID PROGRESSIVE ACUTE DEHYDRATION; CEREBRAL-BLOOD-FLOW; HYDRATION STATUS; PLASMA VASOPRESSIN; HEAT-STRESS; CLINICAL APPLICATION; WATER; OSMOLALITY; EXERCISE; VOLUME AB Dehydration (body water deficit) is a physiologic state that can have profound implications for human health and performance. Unfortunately, dehydration can be difficult to assess, and there is no single, universal gold standard for decision making. In this article, we review the physiologic basis for understanding quantitative dehydration assessment. We highlight how phenomenologic interpretations of dehydration depend critically on the type (dehydration compared with volume depletion) and magnitude (moderate compared with severe) of dehydration, which in turn influence the osmotic (plasma osmolality) and blood volume dependent compensatory thresholds for antidiuretic and thirst responses. In particular, we review new findings regarding the biological variation in osmotic responses to dehydration and discuss how this variation can help provide a quantitative and clinically relevant link between the physiology and phenomenology of dehydration. Practical measures with empirical thresholds are provided as a starting point for improving the practice of dehydration assessment. Am J Clin Nutr 2013;97:455-62. C1 [Cheuvront, Samuel N.; Kenefick, Robert W.; Charkoudian, Nisha; Sawka, Michael N.] USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Cheuvront, SN (reprint author), USA, Thermal & Mt Med Div, Environm Med Res Inst, Kansas St,Bldg 42, Natick, MA 01760 USA. EM samuel.n.cheuvront@us.army.mil FU United States Army Medical Research and Materiel Command FX Supported by the United States Army Medical Research and Materiel Command. NR 97 TC 41 Z9 41 U1 1 U2 42 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0002-9165 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD MAR PY 2013 VL 97 IS 3 BP 455 EP 462 DI 10.3945/ajcn.112.044172 PG 8 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 096UV UT WOS:000315431000003 PM 23343973 ER PT J AU Li, BC Hogue, J Eilers, M Mehrotra, P Hyland, J Holm, T Prosen, T Slavotinek, AM AF Li, Ben C. Hogue, Jacob Eilers, Meg Mehrotra, Pavni Hyland, James Holm, Tara Prosen, Tracy Slavotinek, Anne M. TI Clinical report: Two patients with atelosteogenesis type I caused by missense mutations affecting the same FLNB residue SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A LA English DT Article DE atelosteogenesis type I; FLNB ID SKELETAL DYSPLASIA; PRENATAL-DIAGNOSIS; FEATURES AB We present two patients with Atelosteogenesis Type I (AO type I) caused by two novel Filamin B (FLNB) mutations affecting the same FLNB residue: c.542G>A, predicting p.Gly181Asp and c.542G>C, predicting p.Gly181Arg. Both children had typical manifestations of AO type I, with severe rhizomelic shortening of the extremities, limited elbow and knee extension with mild webbing, pectus excavatum, broad thumbs with brachydactyly that was most marked for digits 35, dislocated hips and bilateral talipes equinovarus. Facial features included proptosis, hypertelorism, downslanting palpebral fissures, cleft palate, and retromicrognathia. The clinical course of one child was influenced by airway instability and bronchopulmonary dysplasia that complicated intubation and prevented separation from ventilator support. Respiratory insufficiency with tracheal hypoplasia, laryngeal stenosis, and pulmonary hypoplasia have all been described in patients with AO type I and we conclude that compromised pulmonary function is a major contributor to morbidity and mortality in this condition. (c) 2013 Wiley Periodicals, Inc. C1 [Li, Ben C.; Mehrotra, Pavni; Slavotinek, Anne M.] Univ Calif San Francisco, Div Genet, Dept Pediat, San Francisco, CA 94143 USA. [Hogue, Jacob] Brooke Army Med Ctr, Div Genet, Dept Pediat, Ft Sam Houston, TX 78234 USA. [Eilers, Meg; Holm, Tara; Prosen, Tracy] Univ Minnesota, Dept Obstet Gynecol & Womens Hlth, Div Maternal Fetal Med, Dept Diagnost Radiol, Minneapolis, MN USA. [Hyland, James] Connect Tissue Gene Tests, Allentown, PA USA. RP Slavotinek, AM (reprint author), Univ Calif San Francisco, Div Genet, Dept Pediat, 533 Parnassus St,Room U585P, San Francisco, CA 94143 USA. EM slavotia@peds.ucsf.edu NR 13 TC 2 Z9 2 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1552-4825 J9 AM J MED GENET A JI Am. J. Med. Genet. A PD MAR PY 2013 VL 161A IS 3 BP 619 EP 625 DI 10.1002/ajmg.a.35792 PG 7 WC Genetics & Heredity SC Genetics & Heredity GA 095NQ UT WOS:000315341700031 PM 23401428 ER PT J AU Cameron, KL Thompson, BS Peck, KY Owens, BD Marshall, SW Svoboda, SJ AF Cameron, Kenneth L. Thompson, Brandon S. Peck, Karen Y. Owens, Brett D. Marshall, Stephen W. Svoboda, Steven J. TI Normative Values for the KOOS and WOMAC in a Young Athletic Population History of Knee Ligament Injury Is Associated With Lower Scores SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE KOOS; WOMAC; norms; reference values; sex; injury history ID OSTEOARTHRITIS INDEX WOMAC; ANTERIOR CRUCIATE LIGAMENT; WESTERN-ONTARIO-UNIVERSITY; CROSS-CULTURAL ADAPTATION; OF-LIFE INSTRUMENTS; RATING-SCALES; VALIDATION; VERSION; PAIN AB Background: The use of patient-reported outcome measures to assess clinical outcomes after injury and surgery has become common in treating young athletes with orthopaedic injuries; however, normative data for these measures are limited and often include a wide range of ages and activity levels. Purpose: To provide normative data for the Knee Injury and Osteoarthritis Outcome Score (KOOS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) in a young and athletic population, and to compare scores between participants with a history of knee ligament injury and those with no history. Study Design: Cross-sectional study; Level of evidence, 3. Methods: We administered the KOOS and WOMAC to 1177 college freshmen entering the United States Military Academy in June 2011. All participants were healthy and had been medically screened to meet the physical induction standards for military service. We calculated means, standard deviations, percentiles, ranges, and interquartile ranges for the KOOS and WOMAC by sex and injury history. We also compared median scale scores for those with a history of knee ligament injury with those with no history using the Kruskal-Wallis test. Results: Among the 1177 participants, 971 were male (age, 18.8 +/- 0.9 years), and the remaining 206 were female (age, 18.7 +/- 0.8 years). Normative median values and interquartile ranges (IQRs) for the KOOS scale scores among men with no history of knee ligament injury were the following: Symptoms (96.4; IQR, 10.7), Pain (100; IQR, 2.8), Functional Activities of Daily Living (ADL) (100; IQR, 0.0), Sports and Recreation Function (100; IQR, 5.0), and Knee-Related Quality of Life (QOL) (100; IQR, 12.5). For women with no history of knee ligament injury, the KOOS scale scores were the following: Symptoms (92.9; IQR, 14.3), Pain (100; IQR, 5.6), Functional ADL (100; IQR, 2.9), Sports and Recreation Function (100; IQR, 10.0), and Knee-Related QOL (93.8; IQR, 18.8). Among the men, 139 (14%) reported a history of knee ligament injury, while 33 (16%) women also reported a history of injury. All KOOS scale scores and the WOMAC Stiffness and Function scale scores were significantly lower (P < .05) for men who reported a history of knee ligament injury. Similarly, Symptoms, Pain, and Knee-Related QOL on the KOOS and Pain on the WOMAC were significantly lower among women with a history of knee ligament injury. Conclusion: Normative values for all KOOS scales suggest a high level of functioning among participants with no history of knee ligament injury. Despite meeting the medical standards for military service, participants with a history of knee ligament injury had significantly lower KOOS and WOMAC scores upon entry to military service. C1 [Cameron, Kenneth L.; Thompson, Brandon S.; Peck, Karen Y.; Owens, Brett D.; Marshall, Stephen W.; Svoboda, Steven J.] US Mil Acad, Keller Army Hosp, West Point, NY 10996 USA. RP Cameron, KL (reprint author), Keller Army Community Hosp, 900 Washington Rd, West Point, NY 10996 USA. EM kenneth.cameron@amedd.army.mil OI Marshall, Stephen/0000-0002-2664-9233; Cameron, Kenneth/0000-0002-6276-4482 NR 25 TC 11 Z9 11 U1 0 U2 8 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD MAR PY 2013 VL 41 IS 3 BP 582 EP 589 DI 10.1177/0363546512472330 PG 8 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 098QG UT WOS:000315563200014 PM 23328737 ER PT J AU Owens, BD Burns, TC Campbell, SE Svoboda, SJ Cameron, KL AF Owens, Brett D. Burns, Travis C. Campbell, Scot E. Svoboda, Steven J. Cameron, Kenneth L. TI Simple Method of Glenoid Bone Loss Calculation Using Ipsilateral Magnetic Resonance Imaging SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE shoulder instability; bone loss; MRI; surgery ID ANTERIOR SHOULDER INSTABILITY; DEFECTS; HISTORY AB Background: Current methods for estimating glenoid bone loss in patients with chronic shoulder instability include computed tomography imaging with 3-dimensional reconstruction, specialized computer software, and imaging of the contralateral shoulder. An ideal method of glenoid measurement would require only magnetic resonance imaging (MRI) of the injured shoulder. Purpose: To determine whether MRI measurement of glenoid height, as well as sex, could be used to estimate glenoid width in healthy subjects with no history of shoulder instability. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Bilateral shoulder MRIs were obtained in a healthy cohort of young athletes as part of the baseline assessment in a prospective cohort study. A musculoskeletal radiologist measured glenoid height and width using the sagittal MRI cuts. Univariate and multivariate regression analyses were performed to determine whether demographic and MRI measurements of the glenoid could be used to estimate glenoid width. Results: Of the 1264 shoulder MRIs evaluated, the mean glenoid width was 26.67 mm (+/- 2.49 mm), and the mean glenoid height was 42.15 mm (+/- 3.00 mm). There were significant differences between the 129 female glenoids and the 1035 male glenoids for both width (23.1 mm, 27.1 mm, respectively, P < .0001) and height (37.9 mm, 42.7 mm, respectively, P < .0001); however, the relationship between glenoid height and width was similar for both men and women. The glenoid width was found to correlate with the height measurement (r = 0.56) for the entire cohort. Based on the results of linear regression analysis, controlling for the influence of sex, a formula was created that represents the relationship between these variables for male subjects: GlenoidWidth = (1/3 Height) + 15 mm. Female patients are estimated with a formula that represents the same slope but a different intercept: W = 1/3 H + 13 mm. Conclusion: Significant differences in glenoid height and width were found by sex; however, the relationship between height and width was similar. These variables are correlated, and the resultant formula can be used to estimate the expected glenoid width in a patient with bone loss. This formula allows for easy calculation of the amount of glenoid bone loss with only a ruler and an MRI of the injured shoulder. C1 [Owens, Brett D.; Burns, Travis C.; Campbell, Scot E.; Svoboda, Steven J.; Cameron, Kenneth L.] US Mil Acad, Keller Army Hosp, West Point, NY 10996 USA. RP Owens, BD (reprint author), Keller Army Hosp, West Point, NY 10996 USA. EM b.owens@us.army.mil OI Cameron, Kenneth/0000-0002-6276-4482 FU Orthopaedic Research and Education Foundation FX One or more of the authors has declared the following potential conflict of interest or source of funding: This study was supported by a prospective research grant from the Orthopaedic Research and Education Foundation. NR 11 TC 6 Z9 7 U1 0 U2 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD MAR PY 2013 VL 41 IS 3 BP 622 EP 624 DI 10.1177/0363546512472325 PG 3 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 098QG UT WOS:000315563200020 PM 23339835 ER PT J AU Dees, RA Nestler, ST Kewley, R AF Dees, Robert A. Nestler, Scott T. Kewley, Robert TI WholeSoldier Performance Appraisal to Support Mentoring and Personnel Decisions SO DECISION ANALYSIS LA English DT Article DE value-focused thinking; performance appraisal; mentoring; personnel decisions; applications: military; practice ID BALANCED SCORECARD AB We present a multiattribute model called Whole Soldier Performance that measures the performance of junior enlisted soldiers in the U.S. Army; currently there is no formal performance appraisal system in place. The application is unique to decision analysis in that we utilize a common constructed scale and single-dimensional value function for all attributes to match the natural framework of model users and based on operability concerns. Additionally, we discuss model validation in both the terms of decision analysis and psychometrics in models that are used for repeated or routine assessments and thus generate significant quantities of data. We highlight visualization of data for use to support mentoring and personnel decisions to better train, assign, retain, promote, and separate current personnel. Last, we address common cultural concerns related to performance appraisals in organizations by offering a method to standardize ratings and hold raters accountable for their responsibility to mentor subordinates as well as identify their performance to the larger organization. C1 [Dees, Robert A.] Univ Texas Austin, McCombs Sch Business, Austin, TX 78712 USA. [Nestler, Scott T.] USN, Postgrad Sch, Dept Operat Res, Monterey, CA 93943 USA. [Kewley, Robert] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. RP Dees, RA (reprint author), Univ Texas Austin, McCombs Sch Business, Austin, TX 78712 USA. EM rob.dees@utexas.edu; scott.nestler@gmail.com; robert.kewley@usma.edu NR 29 TC 2 Z9 2 U1 1 U2 18 PU INFORMS PI HANOVER PA 7240 PARKWAY DR, STE 310, HANOVER, MD 21076-1344 USA SN 1545-8490 J9 DECIS ANAL JI Decis. Anal. PD MAR PY 2013 VL 10 IS 1 BP 82 EP 97 DI 10.1287/deca.1120.0263 PG 16 WC Management SC Business & Economics GA 098HJ UT WOS:000315539600006 ER PT J AU Shen-Gunther, J Rebeles, J AF Shen-Gunther, Jane Rebeles, Jennifer TI Genotyping human papillomaviruses: Development and evaluation of a comprehensive DNA microarray SO GYNECOLOGIC ONCOLOGY LA English DT Article DE HPV; HPV genotyping; HPV microarray; HPV molecular detection; DNA microarray ID SPECIMENS AB Goals. To define the analytical and clinical performance of a human papillomavirus (HPV) custom-designed microarray targeting the HPV L1 gene for viral genotyping. Methods. Microarray probes were designed by cataloging the genome sequence of all 120 known HPV types to generate tiling probes using eArray (R) software against the unique L1 capsid gene segments targeted by MY09/11 and FAP59/64 primers. The microarray (1 slide x 8 arrays x 60 K features) synthesized in situ by inkjet printing was tested using synthetic type-specific HPV DNA and existing HPV DNA from cervical cytology. The synthetic HPV L1 segments (genotypes 6, 11, 16, 18, 31, 33, 35, 45, 53, 58, 66, 73, 83) were manufactured from sequences stored in the NCBI taxonomy database. Using the hybridization patterns of the synthetic HPV DNA as the Support Vector Machine classifier, HPV DNA from patient samples were genotyped and compared to antecedent DNA sequencing/BLAST (R) results for concordance. Results. 16 cytology-derived HPV DNA samples and 13 synthetic type-specific HPV DNA samples were tested singly, in duplicate, or in combination on 40 arrays. The synthetic HPV DNA hybridization patterns were found to be uniquely distinctive to serve well as a classifier of unknown HPV-containing specimens. For the 16 HPV DNA+ samples classified, 15 were concordant with DNA sequencing results. In 6/16 (38%) samples, the microarray hybridization pattern revealed >= 2 concurrent HPV infections. Conclusion. The novel "HPV Array" was sensitive and specific for detecting single and multiple infections. This proof-of-principle project demonstrated the accuracy and advantages of microarray technology for HPV genotyping. Published by Elsevier Inc. C1 [Shen-Gunther, Jane] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. [Rebeles, Jennifer] Greehey Childrens Canc Res Inst, San Antonio, TX 78228 USA. RP Shen-Gunther, J (reprint author), Brooke Army Med Ctr, Dept Clin Invest, ATTN MCHE CI, 3400 Rawley E Chambers Ave,Ste A, Ft Sam Houston, TX 78234 USA. EM jane.shengunther@us.army.mil; rebeles@live.unc.edu FU CTSA grant [UL1TR000149]; CTSA grant from the University of Texas Health Sciences Center at San Antonio, San Antonio, Texas [UL1TR000149]; National Institute on Minority Health and Health Disparities from the National Institutes of Health [G12MD007591] FX This study was supported in part by a CTSA grant (UL1TR000149).; This work was supported in part by a CTSA grant (UL1TR000149) from the University of Texas Health Sciences Center at San Antonio, San Antonio, Texas. Agilent Technologies provided 3 microarrays via a Material Transfer Agreement. GeneSpring GX software support was provided by the Computational System Biology Core at University of Texas at San Antonio, funded by the National Institute on Minority Health and Health Disparities (G12MD007591) from the National Institutes of Health. NR 24 TC 5 Z9 5 U1 0 U2 13 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD MAR PY 2013 VL 128 IS 3 BP 433 EP 441 DI 10.1016/j.ygyno.2012.11.028 PG 9 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 095FU UT WOS:000315320900006 PM 23200917 ER PT J AU Taylor, KF Lanzi, JT Cage, JM Drake, ML AF Taylor, Kenneth F. Lanzi, Joseph T. Cage, J. Matthew Drake, Matthew L. TI Radial Collateral Ligament Injuries of the Thumb Metacarpophalangeal Joint: Epidemiology in a Military Population SO JOURNAL OF HAND SURGERY-AMERICAN VOLUME LA English DT Article DE Radial collateral ligament; thumb; instability ID INSTABILITY; ANCHOR; REPAIR AB Purpose The reasons for variation in the reported incidence rates between thumb metacarpophalangeal joint radial collateral ligament (RCL) and ulnar collateral ligament (UCL) injuries are unclear. Delay in diagnosis of injury to the RCL leads to greater time of patient disability. The purpose of this study was to define the demographics and presentation of patients with RCL injuries in a military health care system. Methods We performed a retrospective review of electronic medical records over a 5-year period to determine the incidence and epidemiology related to patients with instability of the thumb metacarpophalangeal joint resulting from injury of the radial or ulnar collateral ligaments. Results A total of 56 patients presented with thumb metacarpophalangeal joint instability. Of these, 18 (32%) had an RCL injury. Patients with an RCL injury were, on average, younger than those with UCL injuries. Those with RCL injuries were more likely to require surgery than were those with UCL injuries (67% vs 40%). With regard to time to presentation, most patients with UCL injuries presented 2 to 10 weeks after injury, whereas nearly all patients with RCL injuries presented greater than 10 weeks after injury. Radial collateral ligament injuries were more likely than UCL injuries to have resulted from an axial load (56% vs 16%), whereas UCL injuries were more likely to have been caused by an abduction-adduction moment (50% vs 22%). Conclusions In this series, patients sustaining injuries to the RCL were younger and presented later than their counterparts with UCL instability. Close attention to subtle or frank instability presenting as pain in younger patients with axial loading injury mechanisms may allow early diagnosis and appropriate treatment of this injury. (J Hand Surg 2013;38A:532-536. Copyright (C) 2013 by the American Society for Surgery of the Hand. All rights reserved.) C1 [Taylor, Kenneth F.; Lanzi, Joseph T.; Cage, J. Matthew; Drake, Matthew L.] Tripler Army Med Ctr, Orthopaed Surg Serv, Honolulu, HI 96859 USA. RP Taylor, KF (reprint author), Penn State Milton S Hershey Med Ctr, Dept Orthopaed & Rehabil, 30 Hope Dr, Hershey, PA 17033 USA. EM ktaylor3@hmc.psu.edu NR 20 TC 3 Z9 4 U1 0 U2 4 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0363-5023 J9 J HAND SURG-AM JI J. Hand Surg.-Am. Vol. PD MAR PY 2013 VL 38A IS 3 BP 532 EP 536 DI 10.1016/j.jhsa.2012.12.003 PG 5 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 099XW UT WOS:000315660200015 PM 23375785 ER PT J AU Aslan, M Concato, J Peduzzi, PN Proctor, SP Schnurr, PP Marx, BP McFall, M Gleason, T Huang, GD Vasterling, JJ AF Aslan, Mihaela Concato, John Peduzzi, Peter N. Proctor, Susan P. Schnurr, Paula P. Marx, Brian P. McFall, Miles Gleason, Theresa Huang, Grant D. Vasterling, Jennifer J. TI Design of "Neuropsychological and Mental Health Outcomes of Operation Iraqi Freedom: A Longitudinal Cohort Study'' SO JOURNAL OF INVESTIGATIVE MEDICINE LA English DT Article DE posttraumatic stress disorders; brain injuries; traumatic; neuropsychological tests; closed cohort studies; methods ID ADMINISTERED PTSD SCALE; CES-D; DEPLOYMENT; PERSONNEL; VETERANS; WAR AB Objective: This study aimed to describe methodological challenges encountered in designing a follow-up assessment of US Army Soldiers who served in Operation Iraqi Freedom. Study Design and Setting: The Neurocognition Deployment Health Study (NDHS) enrolled 1595 soldiers at 2 military installations, starting in 2003. Prior work compared predeployment and postdeployment assessments among Iraq-deployed and nondeployed soldiers. The current phase, as VA Cooperative Studies Program #566, is collecting follow-up data on participants who were deployed to Iraq or Afghanistan. Specific aims include evaluating the prevalence and course of posttraumatic stress disorder (PTSD), the persistence of previously observed neuropsychological changes, and the relationship of these changes-and traumatic brain injury-to subsequent PTSD. The target sample size is 817 participants, with 200 participants also receiving performance-based neuropsychological assessments. Results: We describe 6 methodological challenges and their implications for longitudinal research among a "closed,'' young, mobile study population: transitioning from cluster-based (battalion) sampling to individual-level sampling; overcoming practical barriers (such as location searches); selecting exposure and outcome measures that combine previously collected and current study data; accounting for loss of an exposed (deployed) versus (nonexposed) nondeployed comparison; determining timing of assessments; and developing a complex statistical analysis plan. Enrollment is ongoing. Conclusions: The study provides unique insights regarding elements of study design and analysis that are relevant to longitudinal research. In particular, the dynamic "real-life'' context of military deployment provides a basis for applying observational methodology to characterize mental health disorders associated with exposure to war-zone deployment and other contexts associated with exposure to extreme stress. C1 [Aslan, Mihaela; Concato, John] VA Connecticut Healthcare Syst, Clin Epidemiol Res Ctr, West Haven, CT 06516 USA. [Aslan, Mihaela; Concato, John] Yale Univ, Sch Med, Dept Med, New Haven, CT 06510 USA. [Peduzzi, Peter N.] Yale Univ, Yale Ctr Analyt Sci, New Haven, CT USA. [Peduzzi, Peter N.] Yale Univ, Sch Publ Hlth, New Haven, CT USA. [Proctor, Susan P.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. [Proctor, Susan P.] VA Boston Healthcare Syst, Res Serv, Boston, MA USA. [Proctor, Susan P.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Schnurr, Paula P.] Geisel Sch Med Dartmouth, Dept Psychiat, Hanover, NH USA. [Schnurr, Paula P.] White River Junction VA Med Ctr, VA Natl Ctr Posttraumat Stress Disorder PTSD, White River Jct, VT USA. [Marx, Brian P.; Vasterling, Jennifer J.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA. [Marx, Brian P.; Vasterling, Jennifer J.] VA Boston Healthcare Syst, Psychol Serv, Boston, MA USA. [Marx, Brian P.; Vasterling, Jennifer J.] VA Boston Healthcare Syst, Natl Ctr PTSD, Boston, MA USA. [McFall, Miles] Univ Washington, Sch Med, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [McFall, Miles] VA Puget Sound Healthcare Syst, Seattle, WA USA. [Gleason, Theresa; Huang, Grant D.] US Dept Vet Affairs, Off Res & Dev, NW, Washington, DC USA. RP Aslan, M (reprint author), VA Connecticut Healthcare Syst, Clin Epidemiol Res Ctr, 950 Campbell Ave,Mailcode 151B, West Haven, CT 06516 USA. EM mihaela.aslan@va.gov FU Department of Veterans Affairs Cooperative Studies Program; Abt SRBI, Inc. FX Supported by the Department of Veterans Affairs Cooperative Studies Program.; The authors thank all the participants in this study. Participants are enrolled by staff at sites in Boston and Seattle, with specific services provided via a contract with Abt SRBI, Inc. The study is managed by the CSP #566 Chair's office at the Boston VA Healthcare System, the VA Clinical Epidemiology Research Center (CERC) at VA Connecticut Healthcare System in West Haven, an Executive Committee, and a Data Monitoring Committee; the entire initiative is overseen by VA Office of Research and Development. In addition to the authors of the paper, the following persons have provided expertise or assistance in the conduct of the study. Boston site: Fabiana Cabral, Meredith Charney, May Chen, Kaitlyn Gorman, Sohyun Han, Darren Holowaka, Heather Kapson, Amy Lawrence, Mary Alice Mills, Nicole Rodier, Paola Rodriguez, and Erin Ulloa. Seattle site: Kate Hoerster, Matthew Jakupcak, David Slagle, David Tice, and Ollie (Richie) Yarbrough. Chair's Office: Molly Franz, Anna Graefe, and Helen MacDonald. West Haven CERC and CSP Coordinating Center: Margaret Antonelli, Donna Cavaliere, Patricia Crutchfield, Maria deAsis, Peter Guarino, Adrienne Hoey, John Ko, Kathy Newvine, Susan O'Neil, Diane Orlando, Thomas Roy, and Joseph Turner. Executive Committee members: Paul Amoroso, Paul Bliese, Charles Hoge, and Theresa O'Connor. Data Monitoring Committee: Haiqun Lin, Scott Orr, Margaret Ryan, Karen Schwab, and Ayumi Shintani. VA Central Office: Timothy O'Leary. CSP Clinical Research Pharmacy Coordinating Center (CSPCRPCC): Clair Haakenson, Darlene Krueger, Amanda Snodgrass, and Kathleen Swanson [Site Monitoring, Auditing and Review Team (SMART)]. NR 28 TC 1 Z9 1 U1 1 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1081-5589 J9 J INVEST MED JI J. Invest. Med. PD MAR PY 2013 VL 61 IS 3 BP 569 EP 577 DI 10.231/JIM.0b013e31828407ff PG 9 WC Medicine, General & Internal; Medicine, Research & Experimental SC General & Internal Medicine; Research & Experimental Medicine GA 097GU UT WOS:000315462800012 PM 23392054 ER PT J AU Ahmed, SI Burns, TC Landt, C Hayda, R AF Ahmed, Syed I. Burns, Travis C. Landt, Cristy Hayda, Roman TI Heterotopic Ossification in High-Grade Open Fractures Sustained in Combat: Risk Factors and Prevalence SO JOURNAL OF ORTHOPAEDIC TRAUMA LA English DT Article DE heterotopic ossification; open fracture; war; combat ID TRAUMATIC BRAIN-INJURY; TOTAL HIP-ARTHROPLASTY; BONE-FORMATION; ECTOPIC OSSIFICATION; ORTHOPEDIC INJURIES; OPERATIVE TREATMENT; KNEE DISLOCATION; PROGENITOR CELLS; CALLUS FORMATION; SEVERITY SCORE AB Objectives: To determine the prevalence and identify the risk factors for heterotopic ossification (HO) formation in high-grade open fractures sustained during combat and to report on the results of HO excision. Design: Retrospective. Setting: United States Army level-1 trauma center. Patients/Participants: Seventy-six consecutive patients with 91 combat-related open Gustilo and Anderson type II and higher fractures were identified from March 1, 2003, through January 30, 2005. Fifty-nine patients with 71 fractures met criteria for study inclusion. Main Outcome Measurements: Fractures were categorized into HO-present and HO-absent groups based on radiographic imaging. Risk factors such as injury mechanism, injury severity score (ISS), Gustilo and Anderson type, injury location, closed head injury, burn, and infection were compared between the groups. Results: HO was present in 27 of 71 open fractures (38.1%). Variables associated with HO formation included ISS (p = 0.02) and injury location although infection and use of negative pressure therapy were not. Ten of 27 fractures with HO underwent excision. HO did not occur or was mild in 25 tibiae. Conclusions: HO is a common sequela of high-grade open fractures sustained in combat. High ISS and injury location to the shoulder, hip, and femur are risk factors for HO formation. The most common regions for HO excision were the elbow, forearm, and hip with mixed results. Importantly, HO did not seem to be a complication of open high-grade tibia fractures. C1 [Ahmed, Syed I.] Landstuhl Reg Med Ctr, Dept Orthopaed Surg, Landstuhl, Germany. [Burns, Travis C.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. [Landt, Cristy] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. [Hayda, Roman] Brown Univ, Rhode Isl Hosp, Warren Alpert Sch Med, Div Orthoped Trauma, Providence, RI 02903 USA. RP Ahmed, SI (reprint author), Med Corps, CMR 402 Box 636, Apo, AE 09180 USA. EM ahmedi01@yahoo.com NR 60 TC 3 Z9 4 U1 1 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0890-5339 J9 J ORTHOP TRAUMA JI J. Orthop. Trauma PD MAR PY 2013 VL 27 IS 3 BP 162 EP 169 DI 10.1097/BOT.0b013e31825cf742 PG 8 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 098CD UT WOS:000315521400013 PM 22584683 ER PT J AU Palacios, G Savji, N da Rosa, AT Guzman, H Yu, XJ Desai, A Rosen, GE Hutchison, S Lipkin, WI Tesh, R AF Palacios, Gustavo Savji, Nazir da Rosa, Amelia Travassos Guzman, Hilda Yu, Xuejie Desai, Aaloki Rosen, Gail Emilia Hutchison, Stephen Lipkin, W. Ian Tesh, Robert TI Characterization of the Uukuniemi Virus Group (Phlebovirus: Bunyaviridae): Evidence for Seven Distinct Species SO JOURNAL OF VIROLOGY LA English DT Article ID VALLEY FEVER VIRUS; HANTAVIRUS-PULMONARY-SYNDROME; M-SEGMENT REASSORTMENT; HIDDEN MARKOV MODEL; GENETIC-CHARACTERIZATION; MOLECULAR EPIDEMIOLOGY; FAMILY BUNYAVIRIDAE; COMPLETE GENOMES; OROPOUCHE VIRUS; NSM PROTEINS AB Evolutionary insights into the phleboviruses are limited because of an imprecise classification scheme based on partial nucleotide sequences and scattered antigenic relationships. In this report, the serologic and phylogenetic relationships of the Uukuniemi group viruses and their relationships with other recently characterized tick-borne phleboviruses are described using full-length genome sequences. We propose that the viruses currently included in the Uukuniemi virus group be assigned to five different species as follows: Uukuniemi virus, EgAn 1825-61 virus, Fin V707 virus, Chize virus, and Zaliv Terpenia virus would be classified into the Uukuniemi species; Murre virus, RML-105-105355 virus, and Sunday Canyon virus would be classified into a Murre virus species; and Grand Arbaud virus, Precarious Point virus, and Manawa virus would each be given individual species status. Although limited sequence similarity was detected between current members of the Uukuniemi group and Severe fever with thrombocytopenia syndrome virus (SFTSV) and Heartland virus, a clear serological reaction was observed between some of them, indicating that SFTSV and Heartland virus should be considered part of the Uukuniemi virus group. Moreover, based on the genomic diversity of the phleboviruses and given the low correlation observed between complement fixation titers and genetic distance, we propose a system for classification of the Bunyaviridae based on genetic as well as serological data. Finally, the recent descriptions of SFTSV and Heartland virus also indicate that the public health importance of the Uukuniemi group viruses must be reevaluated. C1 [Palacios, Gustavo] USA, Med Res Inst Infect Dis, Ctr Genom Sci, Frederick, MD USA. [Savji, Nazir; Desai, Aaloki; Rosen, Gail Emilia; Lipkin, W. Ian] Columbia Univ, Mailman Sch Publ Hlth, Ctr Infect & Immun, New York, NY USA. [da Rosa, Amelia Travassos; Guzman, Hilda; Yu, Xuejie; Tesh, Robert] Univ Texas Med Branch, Dept Pathol, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 USA. [Hutchison, Stephen] 454 Roche Life Sci, Branford, CT USA. RP Palacios, G (reprint author), USA, Med Res Inst Infect Dis, Ctr Genom Sci, Frederick, MD USA. EM gustavo.f.palacios.ctr@us.army.mil RI Palacios, Gustavo/I-7773-2015 OI Palacios, Gustavo/0000-0001-5062-1938 FU Google.org; National Institutes of Health [AI57158]; USAID PREDICT [07-301-7119-52258]; Defense Threat Reduction Agency; U.S. Department of Defense; NIH [HHSN272201000040I/HHSN27200004/DO4] FX This work was supported by Google.org, National Institutes of Health award AI57158 (Northeast Biodefense Center-Lipkin), USAID PREDICT funding source code 07-301-7119-52258 (Center for Infection and Immunity), the Defense Threat Reduction Agency, and the U.S. Department of Defense. R.T., A.T.D.R., X.Y., and H.G. were supported by NIH contract HHSN272201000040I/HHSN27200004/DO4. NR 69 TC 29 Z9 36 U1 0 U2 15 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD MAR PY 2013 VL 87 IS 6 BP 3187 EP 3195 DI 10.1128/JVI.02719-12 PG 9 WC Virology SC Virology GA 095QD UT WOS:000315348500019 PM 23283959 ER PT J AU Singh, J Im, J Watters, EJ Whitten, JE Soares, JW Steeves, DM AF Singh, Jagdeep Im, Jisun Watters, Evan J. Whitten, James E. Soares, Jason W. Steeves, Diane M. TI Thiol dosing of ZnO single crystals and nanorods: Surface chemistry and photoluminescence SO SURFACE SCIENCE LA English DT Article DE Adsorption; Photoemission; Photoluminescence; Raman spectroscopy; Thiol; Work function; Zinc oxide ID ZINC-OXIDE SURFACES; WORK FUNCTION; ADSORPTION; (CH3)(2)S-2; CH3SH; GOLD AB Adsorption of thiols on ZnO(0001) and ZnO nanorods has been investigated using X-ray and ultraviolet photoelectron spectroscopies (XPS and UPS). Ultrahigh vacuum (UHV) dosing of sputter-cleaned ZnO(0001) with methanethiol (MT), 1-dodecanethiol (DDT), and 3-mercaptopropyltrimethoxysilane (MPTMS) leads to S2p peaks with a binding energy of 163.3 eV. Similar results for MPTMS are obtained for sputter-cleaned ZnO(0001) that is pre-dosed with water to form hydroxyl groups. In all cases, the absence of a free thiol S2p peak at 164.2 eV indicates that bonding to the surface occurs via the thiol end of the molecule. A DDT-dosed ZnO(0001) sample stored for 10 days in UHV and heated to temperatures as high as 150 degrees C exhibits minimal changes in its S/Zn atomic ratio, confirming chemisorption and the presence of a strong bond to the surface. UPS shows that MT adsorption on sputtered ZnO(0001) leads to a 0.7 eV increase in work function and perturbation of the MT molecular orbitals, again consistent with chemisorption. Dry ZnO nanorods have been exposed to MT while monitoring their photoluminescence. XPS and Raman spectroscopy confirm thiol adsorption. Relative to thy ZnO, adsorption causes a decrease in intensity of the visible emission peak, but the UV peak remains unchanged. These results indicate that Zn-S bond formation quenches radiative decay to the valence band from defect states, possibly by methanethiolate adsorption filling oxygen vacancies. (C) 2012 Elsevier B.V. All rights reserved. C1 [Singh, Jagdeep; Im, Jisun; Watters, Evan J.; Whitten, James E.] Univ Massachusetts Lowell, Dept Chem, Lowell, MA 01854 USA. [Singh, Jagdeep; Im, Jisun; Watters, Evan J.; Whitten, James E.] Univ Massachusetts Lowell, Ctr Adv Mat, Lowell, MA 01854 USA. [Singh, Jagdeep; Im, Jisun; Watters, Evan J.; Whitten, James E.] Univ Massachusetts Lowell, Ctr High Rate Nanomfg, Lowell, MA 01854 USA. [Soares, Jason W.; Steeves, Diane M.] USA, Natick Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Whitten, JE (reprint author), Univ Massachusetts Lowell, Dept Chem, Lowell, MA 01854 USA. EM james_Whitten@uml.edu; diane.m.steeves.civ@mail.mil FU US Army Natick Soldier Research, Development and Engineering Center [W911QY-10-2-0001] FX This work was supported by the US Army Natick Soldier Research, Development and Engineering Center under contract # W911QY-10-2-0001. This document has been approved for unlimited distribution. NR 25 TC 13 Z9 13 U1 4 U2 61 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0039-6028 J9 SURF SCI JI Surf. Sci. PD MAR PY 2013 VL 609 BP 183 EP 189 DI 10.1016/j.susc.2012.12.006 PG 7 WC Chemistry, Physical; Physics, Condensed Matter SC Chemistry; Physics GA 099GJ UT WOS:000315609200030 ER PT J AU Harris, RD Javitt, MC Glanc, P Brown, DL Dubinsky, T Harisinghani, MG Khati, NJ Kim, YB Mitchell, DG Pandharipande, PV Pannu, HK Podrasky, AE Royal, HD Shipp, TD Siegel, CL Simpson, L Wall, DJ Wong-You-Cheong, JJ Zelop, CM AF Harris, Robert D. Javitt, Marcia C. Glanc, Phyllis Brown, Douglas L. Dubinsky, Theodore Harisinghani, Mukesh G. Khati, Nadia J. Kim, Young Bae Mitchell, Donald G. Pandharipande, Pari V. Pannu, Harpreet K. Podrasky, Ann E. Royal, Henry D. Shipp, Thomas D. Siegel, Cary Lynn Simpson, Lynn Wall, Darci J. Wong-You-Cheong, Jade J. Zelop, Carolyn M. TI ACR Appropriateness Criteria (R) Clinically Suspected Adnexal Mass SO ULTRASOUND QUARTERLY LA English DT Article DE appropriateness criteria; color doppler sonography; transvaginal ultrasound; adnexal masses; ovarian cysts; ovarian malignancy ID 3-DIMENSIONAL POWER DOPPLER; LOGISTIC-REGRESSION MODELS; OVARIAN-CANCER; POSTMENOPAUSAL WOMEN; DIFFERENTIAL-DIAGNOSIS; SONOGRAPHIC FINDINGS; PELVIC MASSES; GRAY-SCALE; CA 125; ULTRASOUND AB Adnexal masses are a common problem clinically and imaging-wise, and transvaginal US (TVUS) is the first-line imaging modality for assessing them in the vast majority of patients. The findings of US, however, should be correlated with the history and laboratory tests, as well as any patient symptoms. Simple cysts are uniformly benign, and most warrant no further interrogation or treatment. Complex cysts carry more significant implications, and usually engender serial ultrasound(s), with a minority of cases warranting a pelvic MRI. Morphological analysis of adnexal masses with gray-scale US can help narrow the differential diagnosis. Spectral Doppler analysis has not proven useful in most well-performed studies. However, the use of color Doppler sonography adds significant contributions to differentiating between benign and malignant masses and is recommended in all cases of complex masses. Malignant masses generally demonstrate neovascularity, with abnormal branching vessel morphology. Optimal sonographic evaluation is achieved by using a combination of gray-scale morphologic assessment and color or power Doppler imaging to detect flow within any solid areas. The ACR Appropriateness Criteria (R) are evidence-based guidelines for specific clinical conditions that are reviewed every two years by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current medical literature from peer reviewed journals and the application of a well-established consensus methodology (modified Delphi) to rate the appropriateness of imaging and treatment procedures by the panel. In those instances where evidence is lacking or not definitive, expert opinion may be used to recommend imaging or treatment. C1 [Harris, Robert D.] Dartmouth Hitchcock Med Ctr, Lebanon, NH 03766 USA. [Javitt, Marcia C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Glanc, Phyllis] Sunnybrook Hlth Sci Ctr, Toronto, ON M4N 3M5, Canada. [Brown, Douglas L.; Wall, Darci J.] Mayo Clin, Rochester, MN USA. [Dubinsky, Theodore] Univ Washington, Sch Med, Seattle, WA USA. [Harisinghani, Mukesh G.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Khati, Nadia J.] George Washington Univ Hosp, Washington, DC USA. [Kim, Young Bae] Tufts Med Ctr, Boston, MA USA. [Kim, Young Bae] Soc Gynecol Oncologists, Chicago, IL USA. [Mitchell, Donald G.] Thomas Jefferson Univ Hosp, Philadelphia, PA 19107 USA. [Pandharipande, Pari V.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Pannu, Harpreet K.] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. [Podrasky, Ann E.] Baptist Hosp Miami, South Miami Ctr Women & Infants, Miami, FL USA. [Royal, Henry D.; Siegel, Cary Lynn] Washington Univ, Med Ctr, Mallinckrodt Inst Radiol, St Louis, MO 63110 USA. [Royal, Henry D.] Soc Nucl Med, Reston, VA 20190 USA. [Shipp, Thomas D.] Brigham & Womens Hosp, Boston, MA 02115 USA. [Shipp, Thomas D.; Simpson, Lynn; Zelop, Carolyn M.] Amer Coll Obstetricians & Gynecologists, Boston, MA USA. [Simpson, Lynn] Columbia Univ, New York, NY USA. [Wong-You-Cheong, Jade J.] Univ Maryland, Sch Med, Baltimore, MD 21201 USA. [Zelop, Carolyn M.] Valley Hosp, Ridgewood, NJ USA. RP Harris, RD (reprint author), Dartmouth Hitchcock Clin, Dept Radiol, 1 Med Ctr Dr, Lebanon, NH 03756 USA. EM rdh@hitchcock.org NR 45 TC 5 Z9 5 U1 1 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0894-8771 J9 ULTRASOUND Q JI Ultrasound Q. PD MAR PY 2013 VL 29 IS 1 BP 79 EP 86 DI 10.1097/RUQ.0b013e3182814d9b PG 8 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 097BQ UT WOS:000315449400010 PM 23358212 ER PT J AU Indest, KJ Hancock, DE Jung, CM Eberly, JO Mohn, WW Eltis, LD Crocker, FH AF Indest, Karl J. Hancock, Dawn E. Jung, Carina M. Eberly, Jed O. Mohn, William W. Eltis, Lindsay D. Crocker, Fiona H. TI Role of Nitrogen Limitation in Transformation of RDX (Hexahydro-1,3,5-Trinitro-1,3,5-Triazine) by Gordonia sp Strain KTR9 SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID ANAEROBIC BIODEGRADATION; DEGRADATION; EXPRESSION; GLNR; METABOLISM; BACTERIA; INSIGHTS; HYDROGEN; REGULON; GENES AB The transcriptome of RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine)-degrading strain Gordonia sp. strain KTR9 and its glnR mutant were studied as a function of nitrogen availability to further investigate the observed ammonium- mediated inhibition of RDX degradation. The results indicate that nitrogen availability is a major determinant of RDX degradation and xplA gene expression in KTR9. C1 [Indest, Karl J.; Hancock, Dawn E.; Jung, Carina M.; Eberly, Jed O.; Crocker, Fiona H.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. [Mohn, William W.; Eltis, Lindsay D.] Univ British Columbia, Dept Microbiol & Immunol, Inst Life Sci, Vancouver, BC V5Z 1M9, Canada. RP Indest, KJ (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. EM Karl.J.Indest@usace.army.mil RI Eltis, Lindsay/J-8272-2015 OI Eltis, Lindsay/0000-0002-6774-8158 FU U.S. Army Corps of Engineers Environmental Quality Research Program; Strategic Environmental Research and Development Program [ER-1609]; Genome BC FX This research was funded in part by the U.S. Army Corps of Engineers Environmental Quality Research Program, the Strategic Environmental Research and Development Program (Project ER-1609), and Genome BC. NR 32 TC 8 Z9 9 U1 2 U2 12 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD MAR PY 2013 VL 79 IS 5 BP 1746 EP 1750 DI 10.1128/AEM.03905-12 PG 5 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 089ES UT WOS:000314893300041 PM 23275513 ER PT J AU Walter, TR Subhash, G Sankar, BV Song, MC Yen, CF AF Walter, T. R. Subhash, G. Sankar, B. V. Song, M. C. Yen, C. F. TI A Novel Method for Dynamic Short-Beam Shear Testing of 3D Woven Composites SO EXPERIMENTAL MECHANICS LA English DT Article DE High strain rate testing; Hopkinson pressure bar; 3D woven composites; Interlaminar shear strength; Short beam shear ID VELOCITY IMPACT DAMAGE; WEAVE GRAPHITE/EPOXY COMPOSITES; ELEVATED-TEMPERATURES; INTERLAMINAR FRACTURE; INDENTATION RESPONSE; BEHAVIOR; DELAMINATION; COMPRESSION; CERAMICS; STRENGTH AB A new test method for performing dynamic short-beam shear tests using a momentum trapped Hopkinson pressure bar is proposed. Angle-interlock 3D woven composite specimens were tested under quasi-static and dynamic loading conditions to determine the effect of loading rate on damage evolution. The equilibrium condition in the composite specimen under dynamic loads was verified using finite element analysis of the experiment. A high speed camera was used to capture delamination initiation and propagation during both quasi-static and dynamic experiments. Analysis of the load-deflection curves and the high speed images revealed a good correlation between the modes of damage initiation and propagation with the features in the loading response. The apparent inter-laminar shear strength and the bending stiffness increased with rate of loading. While the damage was observed to propagate at a relative steady rate during quasi-static loading, the high rate of energy input during dynamic loading resulted in a rapid propagation of damage and a subsequent loss of stiffness in the composite as noted in the load-deflection curve. C1 [Walter, T. R.; Subhash, G.; Sankar, B. V.; Song, M. C.] Univ Florida, Gainesville, FL 32611 USA. [Yen, C. F.] USA, Res Lab RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA. RP Subhash, G (reprint author), Univ Florida, Gainesville, FL 32611 USA. EM subhash@ufl.edu RI Walter, Thomas/K-4857-2015; OI Sankar, Bhavani/0000-0002-4556-1982 FU United States Army Research Office [W911NF-08-1-0120] FX The authors sincerely acknowledge the United States Army Research Office for providing funding for this work (grant number W911NF-08-1-0120). The authors also acknowledge the US Army Research Laboratory for supplying the composite test panels. NR 38 TC 2 Z9 2 U1 1 U2 27 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0014-4851 J9 EXP MECH JI Exp. Mech. PD MAR PY 2013 VL 53 IS 3 BP 493 EP 503 DI 10.1007/s11340-012-9659-4 PG 11 WC Materials Science, Multidisciplinary; Mechanics; Materials Science, Characterization & Testing SC Materials Science; Mechanics GA 094VH UT WOS:000315292000015 ER PT J AU Beaver, JR Jensen, DE Casamatta, DA Tausz, CE Scotese, KC Buccier, KM Teacher, CE Rosati, TC Minerovic, AD Renicker, TR AF Beaver, John R. Jensen, David E. Casamatta, Dale A. Tausz, Claudia E. Scotese, Kyle C. Buccier, Kristen M. Teacher, Catherine E. Rosati, Teodoro C. Minerovic, Alison D. Renicker, Thomas R. TI Response of phytoplankton and zooplankton communities in six reservoirs of the middle Missouri River (USA) to drought conditions and a major flood event SO HYDROBIOLOGIA LA English DT Article DE Drought; Flood; Meroplankton; Phytoplankton; Zooplankton; Reservoirs; Missouri River; Water residence time ID FRESH-WATER PHYTOPLANKTON; LOWLAND RIVER; SUBTROPICAL RESERVOIR; SEASONAL DYNAMICS; LAKE-ERIE; FOOD-WEB; BIOMASS; PLANKTON; GROWTH; MEUSE AB We assessed if the qualitative and quantitative aspects of plankton composition in reservoirs of the middle Missouri River were influenced by hydrologic variability. Phytoplankton and zooplankton communities in six reservoirs of this highly regulated system were sampled between 2004 and 2011 during historic drought, subsequent recovery, and a 100-year flood event. The reservoir system encompasses a broad latitudinal gradient of decreasing depth, decreasing water residence time and increasing trophic state. Phytoplankton communities of the upper three reservoirs were co-dominated by planktonic and meroplanktonic diatoms during the drought, recovery, and flood periods, but the proportion of more silicified meroplanktonic diatoms increased in the lower three reservoirs as water residence time decreased. Peak phytoplankton biovolume usually occurred during spring/early summer and was associated with increased hydrologic inflows and outflows. Zooplankton biomass of the reservoir system was dominated by Daphnia spp., but all zooplankton groups decreased as inflows and outflows accelerated during the recovery and flood periods. Rotifer abundances were higher under turbulent conditions associated with dam operations. Canonical correlation analyses suggested that temperature, water residence time, station depth, and water clarity explained more variance in the structures of phytoplankton and zooplankton communities than bioavailable nutrient parameters. C1 [Beaver, John R.; Tausz, Claudia E.; Scotese, Kyle C.; Buccier, Kristen M.; Teacher, Catherine E.; Rosati, Teodoro C.; Minerovic, Alison D.; Renicker, Thomas R.] BSA Environm Serv Inc, Beachwood, OH USA. [Jensen, David E.] USA, Corps Engineers, Omaha, NE USA. [Casamatta, Dale A.] Univ N Florida, Dept Biol, Jacksonville, FL USA. RP Beaver, JR (reprint author), BSA Environm Serv Inc, Beachwood, OH USA. EM j.beaver@bsaenv.com NR 84 TC 8 Z9 12 U1 7 U2 88 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0018-8158 J9 HYDROBIOLOGIA JI Hydrobiologia PD MAR PY 2013 VL 705 IS 1 BP 173 EP 189 DI 10.1007/s10750-012-1397-1 PG 17 WC Marine & Freshwater Biology SC Marine & Freshwater Biology GA 089BW UT WOS:000314884800014 ER PT J AU Knuth, MA Courville, ZR AF Knuth, Margaret A. Courville, Zoe R. TI Proof of Concept: Firn Air Facility Cooling at Summit Station, Greenland SO JOURNAL OF COLD REGIONS ENGINEERING LA English DT Article DE Greenland; firn; refrigeration AB A firn air cooling system that utilized the natural reservoir of cool air at depth in polar ice sheets was tested at Summit Station, Greenland during the summer of 2010. Cooling is required on station to meet the requirements for food safety and scientific core storage. Firn air cooling is a potential replacement for traditional mechanical cooling systems. The system design, installation, and results of several experiments are presented. The system cooled a 27 m(3) enclosed, insulated structure from -20 to -25 degrees C using a 10-m borehole and a fan pumping the naturally cool air. The system was easy to install in a short time frame and was low cost from an equipment and operating perspective. DOI: 10.1061/(ASCE)CR.1943-5495.0000049. (C) 2013 American Society of Civil Engineers. C1 [Knuth, Margaret A.; Courville, Zoe R.] USA, Erdc, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Knuth, MA (reprint author), USA, Erdc, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM margaret.a.knuth@usace.army.mil; zoe.r.courville@usace.army.mil FU National Science Foundation, Office of Polar Programs-Arctic Research Support and Logistics FX This work was funded by the National Science Foundation, Office of Polar Programs-Arctic Research Support and Logistics. This work could not have been completed without the outstanding assistance received from many CH2M Hill Polar Services (CPS)/Polar Field Services (PFS) staff and drilling support from Ice Core Drilling Services. NR 6 TC 0 Z9 0 U1 1 U2 9 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0887-381X J9 J COLD REG ENG JI J. Cold Reg. Eng. PD MAR PY 2013 VL 27 IS 1 BP 16 EP 28 DI 10.1061/(ASCE)CR.1943-5495.0000049 PG 13 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA 097ID UT WOS:000315466300002 ER PT J AU Aguilar, A Douglas, RB Gordon, E Baumsteiger, J Goldsworthy, MO AF Aguilar, Andres Douglas, Robert B. Gordon, Eric Baumsteiger, Jason Goldsworthy, Matthew O. TI Elevated Genetic Structure in the Coastal Tailed Frog (Ascaphus truei) in Managed Redwood Forests SO JOURNAL OF HEREDITY LA English DT Article DE conservation; landscape; microsatellites; timberlands ID MULTILOCUS GENOTYPE DATA; ALLELE FREQUENCY DATA; POPULATION-STRUCTURE; LANDSCAPE GENETICS; STREAM AMPHIBIANS; NORTHWESTERN CALIFORNIA; DIFFERENTIATION MEASURE; HABITAT FRAGMENTATION; NORTHERN CALIFORNIA; INCIDENT RADIATION AB Landscape alterations have dramatic impacts on the distribution of genetic variation within and among populations and understanding these effects can guide contemporary and future conservation strategies. We initiated a landscape-scale genetic study of the coastal tailed frog (Ascaphus truei) on commercial timberlands within the southern range of the species in Mendocino County (CA, USA). In total, 294 individuals from 13 populations were analyzed at 9 microsatellite loci. None of the sampled populations departed from mutationdrift equilibrium, indicating recent population bottlenecks were not detected in contemporary samples. Fine-scale analysis indicated sampled populations were structured at the watershed level (mean F-ST 0.077 and mean G(ST) 0.425). Landscape analyses suggested wet and moist areas may serve as significant corridors for gene flow within watersheds in this region (r(2) 0.320.54 for moisture-related features). Results indicate populations of frogs may have persisted at this scale through intense periods of timber harvest, making southern range edge populations of coastal tailed frogs resilient to past land use practices. C1 [Aguilar, Andres; Baumsteiger, Jason] Univ Calif Merced, Sch Nat Sci, Merced, CA 95344 USA. [Aguilar, Andres; Baumsteiger, Jason] Univ Calif Merced, Sierra Nevada Res Inst, Merced, CA 95344 USA. [Douglas, Robert B.; Goldsworthy, Matthew O.] Mendocino Redwood Co, Ft Bragg, CA 95437 USA. [Gordon, Eric] Mendocino Redwood Co, Ukiah, CA 95482 USA. RP Aguilar, A (reprint author), Univ Calif Merced, Sch Nat Sci, 5200 N Lake Rd, Merced, CA 95344 USA. EM aaguilar2@ucmerced.edu FU United States Department of Agriculture [2007-35101-18171] FX United States Department of Agriculture(2007-35101-18171) to A.A. NR 98 TC 1 Z9 1 U1 3 U2 57 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1503 J9 J HERED JI J. Hered. PD MAR-APR PY 2013 VL 104 IS 2 BP 202 EP 216 DI 10.1093/jhered/ess138 PG 15 WC Evolutionary Biology; Genetics & Heredity SC Evolutionary Biology; Genetics & Heredity GA 092XI UT WOS:000315155900005 PM 23325865 ER PT J AU Grujicic, M Pandurangan, B Snipes, JS Yen, CF Cheeseman, BA AF Grujicic, M. Pandurangan, B. Snipes, J. S. Yen, C. -F. Cheeseman, B. A. TI Multi-Length Scale-Enriched Continuum-Level Material Model for Kevlar(A (R))-Fiber-Reinforced Polymer-Matrix Composites SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE ballistics; composites; Kevlar; material models; microstructural defects ID LAMINATED COMPOSITES; FIBER-COMPOSITES; DAMAGE; IMPACT AB Fiber-reinforced polymer matrix composite materials display quite complex deformation and failure behavior under ballistic/blast impact loading conditions. This complexity is generally attributed to a number of factors such as (a) hierarchical/multi-length scale architecture of the material microstructure; (b) nonlinear, rate-dependent and often pressure-sensitive mechanical response; and (c) the interplay of various intrinsic phenomena and processes such as fiber twisting, interfiber friction/sliding, etc. Material models currently employed in the computational engineering analyses of ballistic/blast impact protective structures made of this type of material do not generally include many of the aforementioned aspects of the material dynamic behavior. Consequently, discrepancies are often observed between computational predictions and their experimental counterparts. To address this problem, the results of an extensive set of molecular-level computational analyses regarding the role of various microstructural/morphological defects on the Kevlar(A (R)) fiber mechanical properties are used to upgrade one of the existing continuum-level material models for fiber-reinforced composites. The results obtained show that the response of the material is significantly affected as a result of the incorporation of microstructural effects both under quasi-static simple mechanical testing condition and under dynamic ballistic-impact conditions. C1 [Grujicic, M.; Pandurangan, B.; Snipes, J. S.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. [Yen, C. -F.; Cheeseman, B. A.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM gmica@clemson.edu FU Army Research Office (ARO) [W911NF-09-1-0513]; Army Research Laboratory (ARL) [W911NF-06-2-0042] FX The material presented in this article is based on research supported by the Army Research Office (ARO) research contract entitled "Multi-length-scale Material Model Development for Armor-grade Composites" (Contract Number W911NF-09-1-0513) and the Army Research Laboratory (ARL) research contract entitled "Computational Analysis and Modeling of Various Phenomena Accompanying Detonation Explosives Shallow-Buried in Soil" (Contract Number W911NF-06-2-0042). The authors are indebted to Dr. Larry Russell of ARO for his continuous support and interest during the above study. NR 22 TC 12 Z9 12 U1 4 U2 34 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD MAR PY 2013 VL 22 IS 3 BP 681 EP 695 DI 10.1007/s11665-012-0329-6 PG 15 WC Materials Science, Multidisciplinary SC Materials Science GA 089GU UT WOS:000314899800005 ER PT J AU Gregory, SM Spiering, BA Alemany, JA Tuckow, AP Rarick, KR Staab, JS Hatfield, DL Kraemer, WJ Maresh, CM Nindl, BC AF Gregory, Sara M. Spiering, Barry A. Alemany, Joseph A. Tuckow, Alexander P. Rarick, Kevin R. Staab, Jeffery S. Hatfield, Disa L. Kraemer, William J. Maresh, Carl M. Nindl, Bradley C. TI Exercise-Induced Insulin-Like Growth Factor I System Concentrations after Training in Women SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE ENDOCRINE; FREE INSULIN-LIKE GROWTH FACTOR I; GROWTH HORMONE; ENDURANCE TRAINING; RESISTANCE TRAINING; IGF BINDING PROTEINS ID HEAVY-RESISTANCE EXERCISE; BONE-MINERAL DENSITY; IGF-I; SKELETAL-MUSCLE; BINDING-PROTEIN; PHYSICAL CAPACITY; HORMONE; RESPONSES; DIFFERENTIATION; SERUM AB GREGORY, S. M., B. A. SPIERING, J. A. ALEMANY, A. P. TUCKOW, K. R. RARICK, J. S. STAAB, D. L. HATFIELD, W. J. KRAEMER, C. M. MARESH, and B. C. NINDL. Exercise-Induced Insulin-Like Growth Factor I System Concentrations after Training in Women. Med. Sci. Sports Exerc., Vol. 45, No. 3, pp. 420-428, 2013. Introduction: This study examined the effects of short-term physical training on the acute hormonal response (i.e., growth hormone, total and free insulin-like growth factor I [IGF-I], and IGF binding proteins [IGFBP]-1, IGFBP-2, and IGFBP-3) to resistance exercise (RE) in women. Methods: Forty-six women (20.3 +/- 0.3 yr, mass = 64.1 +/- 7.3 kg, height = 165.7 +/- 1.0 cm) were randomly assigned to an endurance training (E), resistance training (R), combined training (R + E), or control (C) group for 8 wk. Subjects completed a standardized bout of RE (six sets of back squats at 10 repetition maximum) before and after training. Blood samples were obtained at rest (PRE), after the third set, immediately postexercise (POST), and at 15 min and 30 min after exercise. Results: Acute RE significantly increased (P < 0.05) serum growth hormone (mean +/- SD; change from PRE to POST = +10.9 +/- 7.5 mu g.L-1), total IGF-I (+66.1 +/- 25.4 mu g.L-1), IGFBP-1 (+2.5 +/- 3.1 mu g.L-1), IGFBP-2 (+86.0 +/- 86.8 mu g.L-1), and IGFBP-3 (+0.69 +/- 0.25 mg.L-1) concentrations and decreased free IGF-I concentrations (-0.14 +/- 0.21 mu g.L-1). After 8 wk of training, total IGF-I concentrations were significantly increased (change in POST concentrations from week 0 to week 8 = +82.5 +/- 120.8 mu g.L-1), and IGFBP-1 concentrations were significantly decreased (-6.7 +/- 13.6 mu g.L-1) during exercise in groups that participated in resistance training (R and R + E); no significant changes were seen after E or C. Conclusions: Participation in resistance training increased total IGF-I and reduced IGFBP-1 concentrations during acute RE, indicating exercise mode-specific adaptations in the circulating IGF-I system. C1 [Gregory, Sara M.; Spiering, Barry A.; Alemany, Joseph A.; Tuckow, Alexander P.; Rarick, Kevin R.; Staab, Jeffery S.; Nindl, Bradley C.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Gregory, Sara M.] Springfield Coll, Dept Exercise & Sports Studies, Springfield, MA USA. [Spiering, Barry A.; Hatfield, Disa L.; Kraemer, William J.; Maresh, Carl M.] Univ Connecticut, Dept Kinesiol, Storrs, CT USA. [Alemany, Joseph A.] Univ S Carolina, Dept Exercise Sci, Columbia, SC 29208 USA. [Hatfield, Disa L.] Univ Rhode Isl, Dept Kinesiol, Kingston, RI 02881 USA. RP Nindl, BC (reprint author), USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. EM Bradley.nindl@us.army.mil FU U.S. Army Medical Research and Materiel Command Bone Health and Military Medical Readiness Research Program FX This research was supported by a grant from the U.S. Army Medical Research and Materiel Command Bone Health and Military Medical Readiness Research Program to BCN. NR 40 TC 18 Z9 18 U1 0 U2 19 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAR PY 2013 VL 45 IS 3 BP 420 EP 428 DI 10.1249/MSS.0b013e3182750bd4 PG 9 WC Sport Sciences SC Sport Sciences GA 094MT UT WOS:000315268700004 PM 23034644 ER PT J AU Hakre, S Arteaga, G Nunez, AE Bautista, CT Bolen, A Villarroel, M Peel, SA Paz-Bailey, G Scott, PT Pascale, JM AF Hakre, Shilpa Arteaga, Griselda Nunez, Aurelio E. Bautista, Christian T. Bolen, Aimee Villarroel, Maria Peel, Sheila A. Paz-Bailey, Gabriela Scott, Paul T. Pascale, Juan M. CA Panama HIV EPI Grp TI Prevalence of HIV and other sexually transmitted infections and factors associated with syphilis among female sex workers in Panama SO SEXUALLY TRANSMITTED INFECTIONS LA English DT Article ID SURVEILLANCE; POPULATIONS; PREVENTION; VIOLENCE; CLIENTS; MEXICO AB Objectives Biological and behavioural surveillance of HIV and sexually transmitted infections (STIs) among populations at highest risk have been used to monitor trends in prevalence and in risk behaviours. Sex work in Panama is regulated through registration with the Social Hygiene Programme, Ministry of Health. We estimated prevalence of HIV and STIs, and factors associated with active syphilis among female sex workers (FSWs). Methods A cross-sectional study using venue-based, time-space sampling was conducted among FSWs in Panama from 2009 to 2010. FSWs were interviewed about sociodemographic characteristics, sexual risk behaviour, health history and drug use using an anonymous structured questionnaire. Blood was collected for serological testing of HIV and other STIs. Factors associated with active syphilis were studied using logistic regression analysis. Results The overall HIV-1 prevalence of 0.7% varied by FSW category; 1.6% in 379 unregistered, and 0.2% in 620 registered FSWs. Overall prevalence (and 95% CI) of STIs were: syphilis antibody, 3.8% (2.7% to 5.2%); herpes simplex virus type 2 antibody (anti-HSV-2), 74.2% (71.4% to 76.9%); hepatitis B surface antigen, 0.6% (0.2% to 1.3%); hepatitis B core antibody, 8.7% (7.0% to 10.6%); and hepatitis C antibody, 0.2% (0.0% to 0.7%). In multivariate analysis, registration (adjusted OR (AOR) =0.35; 95% CI 0.16 to 0.74), having a history of STI (AOR=2.37; 95% CI 1.01 to 5.58), forced sex (AOR=2.47; 95% CI 1.11 to 5.48), and anti-HSV-2 (AOR=10.05; 95% CI 1.36 to 74.38) were associated with active syphilis. Conclusions Although HIV prevalence is low among FSWs in Panama, unregistered FSWs bear a higher burden of HIV and STIs than registered FSWs. Programmes aimed at overcoming obstacles to registration, and HIV, STI and harm reduction among unregistered FSWs is warranted to prevent HIV transmission, and to improve their sexual and reproductive health. C1 [Hakre, Shilpa; Bolen, Aimee; Villarroel, Maria] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Dept Epidemiol & Threat Assessment, Bethesda, MD USA. [Arteaga, Griselda; Pascale, Juan M.] Inst Conmemorat Gorgas Estudios Salud, Panama City, Panama. [Nunez, Aurelio E.] Minist Hlth, Natl HIV AIDS Control Program, Panama City, Panama. [Bautista, Christian T.] Walter Reed Army Inst Res, Dept Prevent Med, Silver Spring, MD USA. [Peel, Sheila A.; Scott, Paul T.] Walter Reed Army Inst Res, US Mil HIV Res Program, Rockville, MD USA. [Paz-Bailey, Gabriela] Del Valle Univ Guatemala, Ctr Estudios Salud, Guatemala City, Guatemala. RP Hakre, S (reprint author), US Mil HIV Res Program, Dept Epidemiol & Threat Assessment, 6720-A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA. EM shakre@hivresearch.org FU Military Infectious Disease Research Program; Republic of Panama; Pan American Health Organization; Global Funds; Centers for Disease Control and Prevention; Panama National Program of HIV FX This work was supported by funds from the Military Infectious Disease Research Program, Secretary of Science and Technology of the Republic of Panama, Pan American Health Organization, Global Funds, Centers for Disease Control and Prevention, Panama National Program of HIV. NR 22 TC 4 Z9 4 U1 1 U2 6 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1368-4973 J9 SEX TRANSM INFECT JI Sex. Transm. Infect. PD MAR PY 2013 VL 89 IS 2 BP 156 EP 164 DI 10.1136/sextrans-2012-050557 PG 9 WC Infectious Diseases SC Infectious Diseases GA 093QZ UT WOS:000315207800021 PM 23002191 ER PT J AU Rosado, JI Johnson, SB McGinnity, KA Cuevas, JP AF Rosado, Javier I. Johnson, Suzanne Bennett McGinnity, Kelly A. Cuevas, Jordan P. TI Obesity Among Latino Children Within a Migrant Farmworker Community SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID BODY-MASS INDEX; US CHILDREN; MOTHERS PERCEPTIONS; PHYSICAL-ACTIVITY; SCHOOL-CHILDREN; YOUNG-CHILDREN; PRIMARY-CARE; ADOLESCENTS; PREVALENCE; OVERWEIGHT AB Background: Childhood obesity has increased substantially among Latino children, placing them at risk for its related health consequences. Limited attention has been given to childhood obesity among Latino migrant farm-working communities. Purpose: To examine, within a migrant farm-working community, (1) the prevalence of obesity among Latino children and parents and (2) parent perceptions of children's weight status and intentions to take corrective action. Methods: Structured interviews were completed with the parents of 495 children seen for well-child office visits in the pediatric department of a community health center during a 15-month period between 2010 and 2011. Medical chart reviews were completed for each child participant. Results: Forty-seven percent of the children were overweight (20%) or obese (27%). In comparison to preschool-aged children, those in elementary and middle school were more likely to be obese. In elementary school, girls were more likely than boys to be overweight or obese. Child obesity was associated with parent obesity. Parental concern about their child's weight was associated with child obesity but not with child overweight. Parental concern was associated with parent intention to address the child's weight, particularly in older children. Analysis was completed in 2012. Conclusions: Interventions are needed that address both childhood obesity and parent weight status among Latino migrant farmworkers. Prevention programs that address the weight status of Latino children who are overweight, but not necessarily obese, are also needed, as their parents tend to be no more concerned about a child who is overweight than one who is normal weight. (Am J Prev Med 2013;44(3S3):S274-S281) (c) 2013 American Journal of Preventive Medicine C1 [Johnson, Suzanne Bennett] Florida State Univ, Coll Med, Tallahassee, FL 32306 USA. [McGinnity, Kelly A.] Florida State Univ, Dept Stat, Tallahassee, FL 32306 USA. [Cuevas, Jordan P.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. RP Rosado, JI (reprint author), 1441 Heritage Blvd, Immokalee, FL 34142 USA. EM javier.rosado@med.fsu.edu FU Robert Wood Johnson Foundation; Robert Wood Johnson Foundation through its national program, Salud America! The RWJF Research Network to Prevent Obesity Among Latino Children FX Publication of this article was supported by the Robert Wood Johnson Foundation.; This study was funded by the Robert Wood Johnson Foundation through its national program, Salud America! The RWJF Research Network to Prevent Obesity Among Latino Children (www.salud-america.org). Salud America!, led by the Institute for Health Promotion Research at The University of Texas Health Science Center at San Antonio, Texas, unites Latino researchers and advocates seeking environmental and policy solutions to the epidemic. NR 37 TC 11 Z9 11 U1 0 U2 13 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD MAR PY 2013 VL 44 IS 3 SU 3 BP S274 EP S281 DI 10.1016/j.amepre.2012.11.019 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 090FD UT WOS:000314963700015 PM 23415193 ER PT J AU Dai, TH Gupta, A Huang, YY Yin, R Murray, CK Vrahas, MS Sherwood, ME Tegos, GP Hamblin, MR AF Dai, Tianhong Gupta, Asheesh Huang, Ying-Ying Yin, Rui Murray, Clinton K. Vrahas, Mark S. Sherwood, Margaret E. Tegos, George P. Hamblin, Michael R. TI Blue Light Rescues Mice from Potentially Fatal Pseudomonas aeruginosa Burn Infection: Efficacy, Safety, and Mechanism of Action SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID ANTIMICROBIAL PHOTODYNAMIC THERAPY; MRSA IN-VITRO; WOUND INFECTIONS; HELICOBACTER-PYLORI; ULTRAVIOLET-LIGHT; VISIBLE-LIGHT; INACTIVATION; BACTERIA; MODEL; RESISTANCE AB Blue light has attracted increasing attention due to its intrinsic antimicrobial effect without the addition of exogenous photosensitizers. However, the use of blue light for wound infections has not been established yet. In this study, we demonstrated the efficacy of blue light at 415 nm for the treatment of acute, potentially lethal Pseudomonas aeruginosa burn infections in mice. Our in vitro studies demonstrated that the inactivation rate of P. aeruginosa cells by blue light was approximately 35-fold higher than that of keratinocytes (P = 0.0014). Transmission electron microscopy revealed blue light-mediated intracellular damage to P. aeruginosa cells. Fluorescence spectroscopy suggested that coproporphyrin III and/or uroporphyrin III are possibly the intracellular photosensitive chromophores associated with the blue light inactivation of P. aeruginosa. In vivo studies using an in vivo bioluminescence imaging technique and an area-under-the-bioluminescence-time-curve (AUBC) analysis showed that a single exposure of blue light at 55.8 J/cm(2), applied 30 min after bacterial inoculation to the infected mouse burns, reduced the AUBC by approximately 100-fold in comparison with untreated and infected mouse burns (P < 0.0001). Histological analyses and terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling (TUNEL) assays indicated no significant damage in the mouse skin exposed to blue light at the effective antimicrobial dose. Survival analyses revealed that blue light increased the survival rate of the infected mice from 18.2% to 100% (P < 0.0001). In conclusion, blue light therapy might offer an effective and safe alternative to conventional antimicrobial therapy for P. aeruginosa burn infections. C1 [Dai, Tianhong; Gupta, Asheesh; Huang, Ying-Ying; Yin, Rui; Sherwood, Margaret E.; Tegos, George P.; Hamblin, Michael R.] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA. [Dai, Tianhong; Gupta, Asheesh; Huang, Ying-Ying; Yin, Rui; Tegos, George P.; Hamblin, Michael R.] Harvard Univ, Sch Med, Dept Dermatol, Boston, MA 02115 USA. [Gupta, Asheesh] Def Inst Physiol & Allied Sci, Delhi, India. [Huang, Ying-Ying] Guangxi Med Univ, Dept Pathol, Nanning, Guangxi, Peoples R China. [Gupta, Asheesh] Third Mil Med Univ, Southwest Hosp, Dept Dermatol, Chongqing, Peoples R China. [Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Vrahas, Mark S.] Massachusetts Gen Hosp, Dept Orthopaed Surg, Boston, MA 02114 USA. [Tegos, George P.] Univ New Mexico, Sch Med, Dept Pathol, Albuquerque, NM 87131 USA. [Hamblin, Michael R.] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA. RP Hamblin, MR (reprint author), Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA. EM hamblin@helix.mgh.harvard.edu RI Huang, Ying-ying/G-3153-2011; OI Huang, Ying-ying/0000-0003-3066-6981; Hamblin, Michael/0000-0001-6431-4605 FU Airlift Research Foundation [109421]; COTA/Smith Nephew grant [2012-16]; CIMIT Innovation grant [13-1033]; NIH [RO1AI050875] FX This study was supported in part by Airlift Research Foundation Extremity Trauma Research grant 109421 (to T. D.), COTA/Smith & Nephew grant 2012-16 (to T. D.), CIMIT Innovation grant 13-1033 (to T. D.), and NIH grant RO1AI050875 (to M. R. H.). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 50 TC 27 Z9 32 U1 2 U2 29 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD MAR PY 2013 VL 57 IS 3 BP 1238 EP 1245 DI 10.1128/AAC.01652-12 PG 8 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 090GU UT WOS:000314968100018 PM 23262998 ER PT J AU Gunosewoyo, H Tipparaju, SK Pieroni, M Wang, Y Doctor, BP Nambiar, MP Kozikowski, AP AF Gunosewoyo, Hendra Tipparaju, Suresh K. Pieroni, Marco Wang, Ying Doctor, Bhupendra P. Nambiar, Madhusoodana P. Kozikowski, Alan P. TI Structural analogs of huperzine A improve survival in guinea pigs exposed to soman SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS LA English DT Article DE Huperzine A analogs; Neuroprotection; Nerve agent; Soman; Acetylcholinesterase ID NOOTROPIC AGENT HUPERZINE; INDUCED OXIDATIVE INJURY; RAT CORTICAL-NEURONS; ANTICHOLINESTERASE ACTIVITY; INDUCED SEIZURES; NERVE AGENTS; TOXICITY; EFFICACY; CHOLINESTERASES; PRETREATMENTS AB Chemical warfare nerve agents such as soman exert their toxic effects through an irreversible inhibition of acetylcholinesterase (AChE) and subsequently glutamatergic function, leading to uncontrolled seizures. The natural alkaloid (-)-huperzine A is a potent inhibitor of AChE and has been demonstrated to exert neuroprotection at an appropriate dose. It is hypothesized that analogs of both (+)- and (-)-huperzine A with an improved ability to interact with NMDA receptors together with reduced AChE inhibition will exhibit more effective neuroprotection against nerve agents. In this manuscript, the tested huperzine A analogs 2 and 3 were demonstrated to improve survival of guinea pigs exposed to soman at either 1.2 or 2 x LD50. (c) 2012 Elsevier Ltd. All rights reserved. C1 [Gunosewoyo, Hendra; Tipparaju, Suresh K.; Pieroni, Marco; Kozikowski, Alan P.] Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA. [Wang, Ying; Doctor, Bhupendra P.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Kozikowski, AP (reprint author), Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, 833 S Wood St, Chicago, IL 60612 USA. EM kozikowa@uic.edu OI Gunosewoyo, Hendra/0000-0003-3897-1948; Pieroni, Marco/0000-0001-9190-3712 FU US Army Medical Research and Material Command [W81XWH-08-1-0201] FX This work was supported by the US Army Medical Research and Material Command (Contract number W81XWH-08-1-0201). H.G. would like to thank Dr. Werner Tuckmantel for his critical proofreading of the manuscript. NR 32 TC 5 Z9 5 U1 2 U2 23 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0960-894X J9 BIOORG MED CHEM LETT JI Bioorg. Med. Chem. Lett. PD MAR 1 PY 2013 VL 23 IS 5 BP 1544 EP 1547 DI 10.1016/j.bmcl.2012.11.083 PG 4 WC Chemistry, Medicinal; Chemistry, Organic SC Pharmacology & Pharmacy; Chemistry GA 086NZ UT WOS:000314693400077 PM 23395652 ER PT J AU Hogan, M Bahta, M Cherry, S Lountos, GT Tropea, JE Zhao, BM Burke, TR Waugh, DS Ulrich, RG AF Hogan, Megan Bahta, Medhanit Cherry, Scott Lountos, George T. Tropea, Joseph E. Zhao, Bryan M. Burke, Terrence R., Jr. Waugh, David S. Ulrich, Robert G. TI Biomolecular Interactions of Small-molecule Inhibitors Affecting the YopH Protein Tyrosine Phosphatase SO CHEMICAL BIOLOGY & DRUG DESIGN LA English DT Article DE affinity screening; competitive binding assay; high-throughput screening; peptide microarray; phosphopeptide; protein tyrosine phosphatase; surface plasmon resonance; Yersinia pestis outer protein H ID SUBSTRATE-TRAPPING MUTANTS; YERSINIA-PESTIS; SH2 DOMAINS; BINDING; LIBRARY; DEPHOSPHORYLATION; IDENTIFICATION; SPECIFICITY; MECHANISM; DISCOVERY AB We have developed competitive and direct binding methods to examine small-molecule inhibitors of protein tyrosine phosphatase activity. Focusing on the Yersinia pestis outer protein H, a potent bacterial protein tyrosine phosphatase, we describe how an understanding of the kinetic interactions involving Yersinia pestis outer protein H, peptide substrates, and small-molecule inhibitors of protein tyrosine phosphatase activity can be beneficial for inhibitor screening, and we further translate these results into a microarray assay for high-throughput screening. C1 [Hogan, Megan; Zhao, Bryan M.; Ulrich, Robert G.] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Bahta, Medhanit; Burke, Terrence R., Jr.] NCI, Biol Chem Lab, Ctr Canc Res, NIH,Frederick Natl Lab Canc Res, Ft Detrick, MD 21702 USA. [Cherry, Scott; Lountos, George T.; Tropea, Joseph E.; Waugh, David S.] NCI, Macromol Crystallog Lab, Ctr Canc Res, NIH,Frederick Natl Lab, Ft Detrick, MD 21702 USA. [Lountos, George T.] SAIC Frederick Inc, Frederick Natl Lab, Basic Sci Program, Frederick, MD 21702 USA. RP Ulrich, RG (reprint author), USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. EM rulrich@bhsai.org RI Burke, Terrence/N-2601-2014; Lountos, George/B-3983-2015 FU Department of Defense; Joint Science and Technology Office; Frederick National Laboratory for Cancer Research; National Institutes of Health [HHSN261200800001E]; Intramural Research Program of the NIH; National Cancer Institute; Center for Cancer Research FX This project was supported in part by an appointment of MH to the Research Participation Program for the U.S. Army Medical Research and Materiel Command, administered by the Oak Ridge Institute for Science and Education through an agreement between the U.S. Department of Energy and the USAMRMC and by funding from: the Department of Defense, Joint Science and Technology Office; federal funds from the Frederick National Laboratory for Cancer Research, National Institutes of Health, under contract HHSN261200800001E; and the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does the mention of trade names, commercial products or organizations imply endorsement by the U.S. Government. NR 31 TC 2 Z9 2 U1 0 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1747-0277 J9 CHEM BIOL DRUG DES JI Chem. Biol. Drug Des. PD MAR PY 2013 VL 81 IS 3 BP 323 EP 333 DI 10.1111/cbdd.12097 PG 11 WC Biochemistry & Molecular Biology; Chemistry, Medicinal SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy GA 090NM UT WOS:000314985900002 PM 23241354 ER PT J AU Funari, T AF Funari, T. TI A Clinical Nurse Specialist's Role in Developing Strategies to Facilitate Early Transfer of Cardiothoracic Patients to the Intermediate Care Unit SO CLINICAL NURSE SPECIALIST LA English DT Meeting Abstract C1 [Funari, T.] Brooke Army Med Ctr, St Hedwig, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0887-6274 J9 CLIN NURSE SPEC JI Clin. Nurse Spec. PD MAR-APR PY 2013 VL 27 IS 2 BP E9 EP E10 PG 2 WC Nursing SC Nursing GA 088YK UT WOS:000314873600023 ER PT J AU Mittelsteadt, PB Hayes, E Mann-Salinas, E Phillips, S Robbins, J Serio-Melvin, ML Shingleton, SK Tubera, D AF Mittelsteadt, P. B. Hayes, E. Mann-Salinas, E. Phillips, S. Robbins, J. Serio-Melvin, M. L. Shingleton, S. K. Tubera, D. TI SESSION C5: PILLARS OF CARE WITHIN A REGIONAL MILITARY BURN CENTER SO CLINICAL NURSE SPECIALIST LA English DT Meeting Abstract C1 [Mittelsteadt, P. B.; Hayes, E.; Mann-Salinas, E.; Phillips, S.; Robbins, J.; Serio-Melvin, M. L.; Shingleton, S. K.; Tubera, D.] USA, Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0887-6274 J9 CLIN NURSE SPEC JI Clin. Nurse Spec. PD MAR-APR PY 2013 VL 27 IS 2 BP E64 EP E64 PG 1 WC Nursing SC Nursing GA 088YK UT WOS:000314873600165 ER PT J AU Mittelsteadt, PB Marchok, D Vanek, A AF Mittelsteadt, P. B. Marchok, D. Vanek, A. TI Individual Perceptions of Collective Teamwork Among Army Forward Surgical Teams SO CLINICAL NURSE SPECIALIST LA English DT Meeting Abstract C1 [Mittelsteadt, P. B.] USA, Inst Surg Res, San Antonio, TX USA. [Marchok, D.] USA, Heidelberg APO, AE USA. [Vanek, A.] USA, Honolulu, HI USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0887-6274 J9 CLIN NURSE SPEC JI Clin. Nurse Spec. PD MAR-APR PY 2013 VL 27 IS 2 BP E35 EP E35 PG 1 WC Nursing SC Nursing GA 088YK UT WOS:000314873600089 ER PT J AU Phillips, S Mann-Salinas, E Mittelsteadt, P Robbins, J Serio-Melvin, ML Shingleton, SK Tubera, D AF Phillips, S. Mann-Salinas, E. Mittelsteadt, P. Robbins, J. Serio-Melvin, M. L. Shingleton, S. K. Tubera, D. TI Education Pillar: Teach, Coach, Mentor, Communicate, Coordinate SO CLINICAL NURSE SPECIALIST LA English DT Meeting Abstract C1 [Phillips, S.] USA, Inst Surg Res, San Antonio, TX USA. [Mann-Salinas, E.; Mittelsteadt, P.; Robbins, J.; Serio-Melvin, M. L.; Shingleton, S. K.; Tubera, D.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0887-6274 J9 CLIN NURSE SPEC JI Clin. Nurse Spec. PD MAR-APR PY 2013 VL 27 IS 2 BP E64 EP E65 PG 2 WC Nursing SC Nursing GA 088YK UT WOS:000314873600167 ER PT J AU Robbins, J Mann-Salinas, E Mittelsteadt, P Phillips, S Serio-Melvin, ML Shingleton, SK Tubera, D AF Robbins, J. Mann-Salinas, E. Mittelsteadt, P. Phillips, S. Serio-Melvin, M. L. Shingleton, S. K. Tubera, D. TI Expert Practitioner as Change Agent: Translating and Implementing Evidence Into Practice SO CLINICAL NURSE SPECIALIST LA English DT Meeting Abstract C1 [Robbins, J.] USA, Inst Surg Res, San Antonio, TX USA. [Mann-Salinas, E.; Mittelsteadt, P.; Phillips, S.; Serio-Melvin, M. L.; Shingleton, S. K.; Tubera, D.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0887-6274 J9 CLIN NURSE SPEC JI Clin. Nurse Spec. PD MAR-APR PY 2013 VL 27 IS 2 BP E64 EP E64 PG 1 WC Nursing SC Nursing GA 088YK UT WOS:000314873600166 ER PT J AU Robbins, JR Allen, DA Mann-Salinas, E Serio-Melvin, ML AF Robbins, J. R. Allen, D. A. Mann-Salinas, E. Serio-Melvin, M. L. TI A Comparison of 3 Burn Resuscitation Formulas: The Clinical Nurse Specialist Role SO CLINICAL NURSE SPECIALIST LA English DT Meeting Abstract C1 [Robbins, J. R.; Allen, D. A.] USA, Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0887-6274 J9 CLIN NURSE SPEC JI Clin. Nurse Spec. PD MAR-APR PY 2013 VL 27 IS 2 BP E14 EP E15 PG 2 WC Nursing SC Nursing GA 088YK UT WOS:000314873600037 ER PT J AU Rose, T AF Rose, T. TI Track and Trigger: Implementing an Early Warning Scoring System in the Intermediate Care Unit SO CLINICAL NURSE SPECIALIST LA English DT Meeting Abstract C1 [Rose, T.] USA, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0887-6274 J9 CLIN NURSE SPEC JI Clin. Nurse Spec. PD MAR-APR PY 2013 VL 27 IS 2 BP E51 EP E52 PG 2 WC Nursing SC Nursing GA 088YK UT WOS:000314873600132 ER PT J AU Shingleton, S Mann-Salinas, E Phillips, S Robbins, J Seriomelvin, ML Tubera, D AF Shingleton, S. Mann-Salinas, E. Phillips, S. Robbins, J. Seriomelvin, M. L. Tubera, D. TI Wounds, Wounds, Wounds: The Clinical Nurse Specialist's Role in a Burn Center SO CLINICAL NURSE SPECIALIST LA English DT Meeting Abstract C1 [Shingleton, S.] USA, Inst Surg Res, San Antonio, TX USA. [Mann-Salinas, E.; Phillips, S.; Robbins, J.; Seriomelvin, M. L.; Tubera, D.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0887-6274 J9 CLIN NURSE SPEC JI Clin. Nurse Spec. PD MAR-APR PY 2013 VL 27 IS 2 BP E65 EP E65 PG 1 WC Nursing SC Nursing GA 088YK UT WOS:000314873600168 ER PT J AU Tubera, D Savell, K AF Tubera, D. Savell, K. TI Burn Care Program: Building Clinical Competency for Air Force Critical Care/Emergency Nursing Fellows SO CLINICAL NURSE SPECIALIST LA English DT Meeting Abstract C1 [Tubera, D.] USA, Inst Surg Res, San Antonio, TX USA. [Savell, K.] USAF, Lackland AFB, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0887-6274 J9 CLIN NURSE SPEC JI Clin. Nurse Spec. PD MAR-APR PY 2013 VL 27 IS 2 BP E5 EP E6 PG 2 WC Nursing SC Nursing GA 088YK UT WOS:000314873600014 ER PT J AU Quinn, MJ Hanna, TL Shiflett, AA McFarland, CA Cook, ME Johnson, MS Gust, KA Perkins, EJ AF Quinn, Michael J. Hanna, Terry L. Shiflett, Alicia A. McFarland, Craig A. Cook, Michelle E. Johnson, Mark S. Gust, Kurt A. Perkins, Edward J. TI Interspecific effects of 4A-DNT (4-amino-2,6-dinitrotoluene) and RDX (1,3,5-trinitro-1,3,5-triazine) in Japanese quail, Northern bobwhite, and Zebra finch SO ECOTOXICOLOGY LA English DT Article DE Interspecies; Munitions; Explosive; Avian; Ecotoxicology ID COLINUS-VIRGINIANUS; EXPOSURE; GENOMICS; SONGBIRD; BRAIN AB The purpose of this study was to assess the toxicological effects of two munition compounds, 4-amino-2,6-dinitrotoluene (4A-DNT) and 1,3,5-trinitro-1,3,5-triazine (RDX), on three different bird species: two common toxicological model species-the Northern Bobwhite (Colinus virginianus) and the Japanese Quail (Coturnix japonica), and a representative passerine-the Zebra Finch (Taeniopygia guttata). Bobwhite were exposed to 4A-DNT at 0, 8, 15, 30, 60, or 150 mg/kg body weight (bw) d by oral gavage for seven days; because the high dose of 4A-DNT was lethal to bobwhite, the maximum dose was changed to 100 mg/kg bw d for Japanese quail and finches to ensure tissue could be used for future toxicogenomic work. RDX was similarly administered at 0, 0.5, 1.5, 3, 6, or 12 mg/kg bw d. Blood was drawn prior to euthanasia for blood cellularity and chemistry analyses. Finches were clearly least affected by 4A-DNT as evidenced by a lack of observable effects. Bobwhite appeared to be the most sensitive species to 4A-DNT as observed through changes in blood cellularity and plasma chemistry effects. Bobwhite appeared to be more sensitive to RDX than Japanese Quail due to increased effects on measures of plasma chemistries. Finches exhibited the greatest sensitivity to RDX through increased mortality and seizure activity. This study suggests that sensitivity among species is chemical-specific and provides data that could be used to refine current avian sensitivity models used in ecological risk assessments. C1 [Quinn, Michael J.; Hanna, Terry L.; Shiflett, Alicia A.; McFarland, Craig A.; Johnson, Mark S.] USA, Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. [Cook, Michelle E.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37830 USA. [Gust, Kurt A.; Perkins, Edward J.] US Army Corps Engineers, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Quinn, MJ (reprint author), USA, Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. EM michael.james.quinn@us.army.mil FU US Army 6.2 Research Program, Focus Area: Impact of Munitions Constituents on Biological Networks FX This study was funded by US Army 6.2 Research Program, Focus Area: Impact of Munitions Constituents on Biological Networks NR 33 TC 2 Z9 2 U1 0 U2 23 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0963-9292 J9 ECOTOXICOLOGY JI Ecotoxicology PD MAR PY 2013 VL 22 IS 2 BP 231 EP 239 DI 10.1007/s10646-012-1019-8 PG 9 WC Ecology; Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 089GF UT WOS:000314898100003 PM 23161369 ER PT J AU O'Brien, C Cadarette, BS AF O'Brien, Catherine Cadarette, Bruce S. TI Quantification of head sweating during rest and exercise in the heat SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE Evaporation; Heat loss; Helmet ID INDUSTRIAL SAFETY HELMETS; REGIONAL DIFFERENCES; HUMID HEAT; BODY; TEMPERATURE; SECRETION; HYPERTHERMIA; ACCLIMATION; EVAPORATION; RESPONSES AB The head's capacity for evaporative heat loss is important for design of protective helmets for use in hot environments. This study quantified head sweating rate (m (sw)) in eight males during rest and exercise at three metabolic rates (338 +/- A 36, 481 +/- A 24, 622 +/- A 28 W) in hot-dry (HD: 45 A degrees C, 21 % RH) and hot-wet (HW: 35 A degrees C, 69 % RH) conditions (matched at 31.6 A degrees C WBGT), which were counterbalanced. Heads were shaved, and surface area was (458 +/- A 61 cm(2)) measured by 3D scanner. For measurement of head m (sw), dry air was passed through a sealed helmet, whereas for forearm m (sw) a capsule (15.9 cm(2)) was ventilated with ambient air. Evaporation rate was determined from the increase in vapor pressure in the exiting air. Whole-body sweat loss was calculated from the change in nude weight plus fluid intake and corrected for respiratory fluid losses. Head m (sw) increased (p = 0.001) with metabolic rate, and was lower (p = 0.018) in HD (0.4 +/- A 0.2 mg cm(-2) min(-1) at rest to 1.1 +/- A 0.6 mg cm(-2) min(-1) at 622 W), compared to HW (0.5 +/- A 0.3-1.4 +/- A 0.8 mg cm(-2) min(-1)). Forearm m (sw) increased (p < 0.001) with metabolic rate, but was higher (p = 0.002) in HD (0.4 +/- A 0.3-1.4 +/- A 0.7 mg cm(-2) min(-1)) than HW (0.1 +/- A 0.1-1.1 +/- A 0.3 mg cm(-2) min(-1)). Whole-body sweat loss was not significantly different (p = 0.06) between HD (647 +/- A 139 g m(-2) h(-1)) and HW (528 +/- A 189 g m(-2) h(-1)). This study demonstrates the importance of the head for evaporative heat loss, particularly for populations who wear protective clothing which can impair vapor transfer from the skin. C1 [O'Brien, Catherine; Cadarette, Bruce S.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP O'Brien, C (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM kate.obrien@us.army.mil NR 36 TC 2 Z9 2 U1 0 U2 13 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1439-6319 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD MAR PY 2013 VL 113 IS 3 BP 735 EP 741 DI 10.1007/s00421-012-2482-x PG 7 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 087PF UT WOS:000314773500020 PM 22941031 ER PT J AU Harrison, SA Abdurakhmanov, D Shiffman, ML Bakulin, I Mazur, W Rodriguez-Torres, M Silva, GF Cheinquer, H Messinger, D Connell, EV McKenna, M Tatsch, F Reddy, KR AF Harrison, Stephen A. Abdurakhmanov, Djamal Shiffman, Mitchell L. Bakulin, Igor Mazur, Wlodzimierz Rodriguez-Torres, Maribel Silva, Giovanni Faria Cheinquer, Hugo Messinger, Diethelm Connell, Edward V. McKenna, Michael Tatsch, Fernando Reddy, K. Rajender CA PROGRESS Investigators TI Intensified Peginterferon alpha-2a Dosing Increases Sustained Virologic Response Rates in Heavy, High Viral Load Hepatitis C Genotype 1 Patients With High Low-density Lipoprotein SO JOURNAL OF CLINICAL GASTROENTEROLOGY LA English DT Article DE chronic hepatitis C; low-density lipoprotein; pegylated interferon; ribavirin; sustained virologic response ID VIRUS-INFECTION; PLUS RIBAVIRIN; CHOLESTEROL LEVELS; SERUM-CHOLESTEROL; VERY-LOW; THERAPY; TELAPREVIR; STEATOSIS; RECEPTOR; TRIAL AB Background and Goal: Patients infected with hepatitis C virus (HCV) with elevated low-density lipoprotein (LDL) levels achieve higher sustained virologic response (SVR) rates after peginterferon (PegIFN)/ribavirin treatment versus patients with lower LDL. Our aim was to determine whether SVR rates in patients with low/elevated LDL can be improved by dose intensification. Study: In PROGRESS, genotype 1 patients with baseline HCV RNA >= 400,000 IU/mL and body weight >= 85 kg were randomized to 48 weeks of 180 mu g/wk PegIFN alpha-2a (40 kDa) plus ribavirin (A: 1200 mg/d; B: 1400/1600 mg/d) or 12 weeks of 360 mu g/wk PegIFN alpha-2a followed by 36 weeks of 180 mu g/wk, plus ribavirin (C: 1200 mg/d; D: 1400/1600 mg/d). This retrospective analysis assessed SVR rates among patients with low (< 100 mg/dL) or elevated (>= 100 mg/dL) LDL. Patients with high LDL (n = 256) had higher baseline HCV RNA (5.86 x 10(6) IU/mL) versus patients with low LDL (n = 262; 4.02 x 10(6) IU/mL; P = 0.0003). Results: Multiple logistic regression analysis identified a significant interaction between PegIFN alpha-2a dose and LDL levels on SVR (P = 0.0193). The only treatment-related SVR predictor in the nested multiple logistic regression was PegIFN alpha-2a dose among patients with elevated LDL (P = 0.0074); therefore, data from the standard (A + B) and induction (C + D) dose arms were pooled. Among patients with low LDL, SVR rates were 40% and 35% in the standard and induction-dose groups, respectively; SVR rates in patients with high LDL were 44% and 60% (P = 0.014), respectively. Conclusions: Intensified dosing of PegIFN alpha-2a increases SVR rates in patients with elevated LDL even with the difficult-to-cure characteristics of genotype 1, high baseline viral load, and high body weight. C1 [Harrison, Stephen A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Shiffman, Mitchell L.] Bon Secours Hlth Syst, Liver Inst Virginia, Newport News, VA USA. [Abdurakhmanov, Djamal] Moscow Med Acad, Moscow, Russia. [Bakulin, Igor] Minist Def Russian Federat, State Postgrad Med Inst, Moscow, Russia. [Mazur, Wlodzimierz] Med Univ Silesia, Chorzow, Poland. [Rodriguez-Torres, Maribel] Fdn Invest Diego Santurce, Santurce, PR USA. [Silva, Giovanni Faria] Botucatu Sch Med, Botucatu, SP, Brazil. [Cheinquer, Hugo] Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil. [Messinger, Diethelm] IST GmbH, Mannheim, Germany. [Connell, Edward V.] Roche, Nutley, NJ USA. [McKenna, Michael] Roche, Welwyn Garden City, England. [Tatsch, Fernando] Roche, Basel, Switzerland. [Reddy, K. Rajender] Univ Penn, Philadelphia, PA 19104 USA. RP Harrison, SA (reprint author), Brooke Army Med Ctr, Div Gastroenterol & Hepatol, Ft Sam Houston, TX 78234 USA. EM stephen.a.harrison@us.army.mil RI Bakulin, I. G./P-4453-2014 OI Bakulin, I. G./0000-0002-6151-2021 FU Roche, Basel, Switzerland; Merck; Pfizer; Genentech; Biolex; Celera Diagnostics, LLC; Conatus Pharmaceuticals; Exalenz; Gilead Sciences Inc.; GlaxoSmithKline; GlobeImmune Inc.; Human Genome Sciences Inc.; Idenix Pharmaceuticals; Johnson & Johnson/Tibotec; Pharmasset Inc.; Roche; Romark Laboratories, LC; Schering-Plough; Valeant; Vertex Pharmaceuticals; Wyeth; ZymoGenetics; Anadys; Vertex; Hoffman La Roche; Genetech; Glaxo Smith Kline; Novartis; Bristol-Myers Squibb; Vertex Pharm; Idera; Pharmasset; Sanofi-Aventis; Abbott Labs; Human Genome Sciences; Gilead; Johnson Johnson; Akros; Scynexis; Santaris; Mochida; Boehringer Ingelheim; Inhibitex; Idenix; Siemens; Roche-Genentech; Tibotec FX Supported by Roche, Basel, Switzerland. Support for third-party writing assistance for this manuscript was provided by F. Hoffmann-La Roche Ltd. The view(s) expressed herein are those of the author(s) and do not reflect the official policy or position of Brooke Army Medical Center, the U.S. Army Medical Department, the U.S. Army Office of the Surgeon General, the Department of the Army, Department of Defense, or the U.S. Government.; S.A.H. is a consultant for Merck; has served on advisory boards for Merck and Bristol-Myers Squibb; has served on speakers' bureaux for Merck and Bristol-Myers Squibb; and has received research grants/contracts from Merck, Pfizer, and Genentech. M. L. S. has served on advisory committees or review panels for Anadys Pharmaceuticals Inc., Bayer, Biolex, Bristol-Myers Squibb, Celera Diagnostics, LLC, Conatus Pharmaceuticals, Echosense, Exalenz, Gilead Sciences Inc., Human Genome Sciences Inc., Merck & Co Inc., Schering-Plough, Pfizer Inc., Roche, Romark Laboratories, LC, Salix Pharmaceuticals, Valeant, Vertex Pharmaceuticals, and ZymoGenetics; has served as a consultant for Celera Diagnostics, LLC, Conatus Pharmaceuticals, Exalenz, Human Genome Sciences Inc., Pfizer Inc., and Roche; has received research grant support from Biolex, Celera Diagnostics, LLC, Conatus Pharmaceuticals, Exalenz, Gilead Sciences Inc., GlaxoSmithKline, GlobeImmune Inc., Human Genome Sciences Inc., Idenix Pharmaceuticals, Johnson & Johnson/Tibotec, Pharmasset Inc., Roche, Romark Laboratories, LC, Schering-Plough, Valeant, Vertex Pharmaceuticals, Wyeth, and ZymoGenetics; has served on the speakers' bureaux for Bayer, Bristol-Myers Squibb, Gilead Sciences Inc., Roche, and Schering-Plough; has served on the data monitoring board for Abbott Laboratories and Anadys Pharmaceuticals Inc.; and holds stock options for Exalenz. I. B. is a consultant for MSD, Roche, and Bristol-Myers Squibb; and has served on speakers' bureaux for MSD, Roche, and Bristol-Myers Squibb. W. M. has served on advisory committees for Bristol-Myers Squibb and has served on speakers' bureaux for Roche and Bristol-Myers Squibb. He has obtained travel accommodations/meeting expenses from Bristol-Myers Squibb, Roche, and Gilead. M.R.-T. has served as a consultant for Genentech Inc./Hoffmann-La Roche Ltd., Abbott Labs, Pharmasset, Akros, Genentech, Bristol-Myers Squibb, Novartis, Merck, Inhibitex, Santaris and Glaxo Smith Kline; has received grants/research support from Vertex, Anadys, Hoffman La Roche, Genetech, Glaxo Smith Kline, Novartis, Bristol-Myers Squibb, Vertex Pharm, Idera, Pharmasset, Sanofi-Aventis, Merck, Abbott Labs, Pfizer, Human Genome Sciences, Gilead, Johnson & Johnson, Zymogenetics, Akros, Pfizer, Merck, Scynexis, Santaris, Mochida, Boehringer Ingelheim, Inhibitex, Idenix, and Siemens. G. F. S. has served on speakers' bureaux for Roche and Merck; has received research grants/contracts from Roche and Merck; has received travel grants from Roche and Merck. H. C. has served on advisory boards for Roche; has served on speakers' bureaux for Roche and Bristol-Myers Squibb; has received research grants/contracts from Roche and Bristol-Myers Squibb; and has received travel grants from Roche. D. M. is an employee of IST, which contracts with Roche to provide services including statistical support. E. V. C., M. M., and F. T. are employees of F. Hoffmann-La Roche Ltd. K. R. R. has served on advisory boards for Roche-Genentech, Gilead, Merck, Tibotec, and Vertex; has received research grants/contracts from Roche-Genentech, Gilead, Merck, Tibotec, and Vertex. D. A. declares that there is nothing to disclose. NR 43 TC 2 Z9 2 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0192-0790 J9 J CLIN GASTROENTEROL JI J. Clin. Gastroenterol. PD MAR PY 2013 VL 47 IS 3 BP 271 EP 279 DI 10.1097/MCG.0b013e31826102eb PG 9 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 088UY UT WOS:000314863800017 PM 22951527 ER PT J AU Jacobs, RN Benson, JD Stoltz, AJ Almeida, LA Farrell, S Brill, G Salmon, M Newell, A AF Jacobs, R. N. Benson, J. D. Stoltz, A. J. Almeida, L. A. Farrell, S. Brill, G. Salmon, M. Newell, A. TI Analysis of thermal cycle-induced dislocation reduction in HgCdTe/CdTe/Si(211) by scanning transmission electron microscopy SO JOURNAL OF CRYSTAL GROWTH LA English DT Article DE Characterization; Defects; Molecular beam epitaxy; Semiconducting II-VI materials; Semiconducting mercury compounds; Infrared devices ID MOLECULAR-BEAM EPITAXY; (112)B HGCDTE/CDTE/SI; CDTE HETEROEPITAXY; HGCDTE; SI; DENSITY AB High threading dislocation densities limit the operability of infrared focal plane arrays based on large lattice-mismatched heterostructures such as HgCdTe/CdTe/Si. Recently it has been shown that post-growth thermal cycle annealing can routinely reduce the surface etch pit density from >5 x 10(6) cm(-2) to as low as 9 x 10(5) cm(-2). To fully exploit the procedure, a deeper understanding of the inherent dislocation dynamics is needed. In this work, we employ scanning transmission electron microscopy to analyze cross-sectional samples of HgCdTe/CdTe/Si prepared using site-specific focused ion beam milling. A key factor in this work is the use of defect decorated samples, which has allowed for a correlation of surface etch pits to dislocation segments observed in cross-section images. We have observed that the previously reported oval-shaped etch pits are likely associated with Shockley partial type dislocations, and that triangular etch pits are associated with perfect dislocations. This suggests the likelihood that interaction between mobile Shockley partial and other dislocation types are responsible in part for the observed reduction in top surface etch pit density. These studies provide a deeper understanding of dislocation reduction processes which are critical for the realization of high performance infrared detectors based on low-cost, lattice-mismatched substrates. Published by Elsevier B.V. C1 [Jacobs, R. N.; Benson, J. D.; Stoltz, A. J.; Almeida, L. A.] USA, RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. [Farrell, S.; Brill, G.] USA, Res Lab, Ft Belvoir, VA 22060 USA. RP Jacobs, RN (reprint author), USA, RDECOM, CERDEC Night Vis & Elect Sensors Directorate, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. EM info@army.nvl.mil RI Brill, Gregory/G-4877-2013 NR 20 TC 4 Z9 4 U1 0 U2 16 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0248 J9 J CRYST GROWTH JI J. Cryst. Growth PD MAR 1 PY 2013 VL 366 BP 88 EP 94 DI 10.1016/j.jcrysgro.2012.12.007 PG 7 WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied SC Crystallography; Materials Science; Physics GA 088HN UT WOS:000314824800017 ER PT J AU Lever, JH Delaney, AJ Ray, LE Trautmann, E Barna, LA Burzynski, AM AF Lever, J. H. Delaney, A. J. Ray, L. E. Trautmann, E. Barna, L. A. Burzynski, A. M. TI Autonomous GPR Surveys using the Polar Rover Yeti SO JOURNAL OF FIELD ROBOTICS LA English DT Article ID COOL-ROBOT AB The National Science Foundation operates stations on the ice sheets of Antarctica and Greenland to investigate Earth's climate history, life in extreme environments, and the evolution of the cosmos. Understandably, logistics costs predominate budgets due to the remote locations and harsh environments involved. Currently, manual ground-penetrating radar (GPR) surveys must preceed vehicle travel across polar ice sheets to detect subsurface crevasses or other voids. This exposes the crew to the risks of undetected hazards. We have developed an autonomous rover, Yeti, specifically to conduct GPR surveys across polar ice sheets. It is a simple four-wheel-drive, battery-powered vehicle that executes autonomous surveys via GPS waypoint following. We describe here three recent Yeti deployments, two in Antarctica and one in Greenland. Our key objective was to demonstrate the operational value of a rover to locate subsurface hazards. Yeti operated reliably at 30 degrees C, and it has has good oversnow mobility and adequate GPS accuracy for waypoint-following and hazard georeferencing. It has acquired data on hundreds of crevasse encounters to improve our understanding of heavily crevassed traverse routes and to develop automated crevasse-detection algorithms. Importantly, it helped to locate a previously undetected buried building at the South Pole. Yeti can improve safety by decoupling survey personnel from the consequences of undetected hazards. It also enables higher-quality systematic surveys to improve hazard-detection probabilities, increase assessment confidence, and build datasets to understand the evolution of these regions. Yeti has demonstrated that autonomous vehicles have great potential to improve the safety and efficiency of polar logistics. (c) 2012 Wiley Periodicals, Inc. C1 [Lever, J. H.; Delaney, A. J.; Barna, L. A.; Burzynski, A. M.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Ray, L. E.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. [Trautmann, E.] Stanford Univ, Neurosci Program, Stanford, CA 94305 USA. RP Lever, JH (reprint author), USA, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM james.lever@us.army.mil; laura.e.ray@dartmouth.edu FU NASA's Jet Propulsion Laboratory [RSA 1310519]; NSF-OPP divisions of Antarctic Infrastructure and Logistics and Arctic Research Support and Logistics FX Field deployments were sponsored by NSF-OPP divisions of Antarctic Infrastructure and Logistics and Arctic Research Support and Logistics, and the authors sincerely thank George Blaisdell and Pat Haggerty for their commitments to advancing autonomous GPR surveys. These deployments would not have been possible without the help of field personnel, including Paul Thur and Terry Billings (SPoT), Jay Burnside, Geoff Phillips, and Jake MacArthur (GrIT), and Martin Lewis and Andy Martinez (Old Pole). We also thank CRREL's Steve Arcone and Zoe Courville for advice, the loan of GPR equipment, and manual GPR support, and Doug Punt for tireless troubleshooting and upgrades to Yeti's electronics. Funding to build Yeti was provided by NASA's Jet Propulsion Laboratory through RSA 1310519 and supported in part by an appointment to the Postgraduate Research Participation Program administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and CRREL. NR 29 TC 8 Z9 8 U1 5 U2 23 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1556-4959 J9 J FIELD ROBOT JI J. Field Robot. PD MAR-APR PY 2013 VL 30 IS 2 BP 194 EP 215 DI 10.1002/rob.21445 PG 22 WC Robotics SC Robotics GA 087JM UT WOS:000314757600002 ER PT J AU Sun, W Eckels, KH Putnak, JR Lyons, AG Thomas, SJ Vaughn, DW Gibbons, RV Fernandez, S Gunther, VJ Mammen, MP Statler, JD Innis, BL AF Sun, Wellington Eckels, Kenneth H. Putnak, J. Robert Lyons, Arthur G. Thomas, Stephen J. Vaughn, David W. Gibbons, Robert V. Fernandez, Stefan Gunther, Vicky J. Mammen, Mammen P., Jr. Statler, John D. Innis, Bruce L. TI Experimental Dengue Virus Challenge of Human Subjects Previously Vaccinated With Live Attenuated Tetravalent Dengue Vaccines SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE dengue; tetravalent vaccine; live virus challenge ID FLAVIVIRUS-NAIVE ADULTS; PHASE-I TRIAL; HUMAN VOLUNTEERS; CANDIDATE VACCINES; RHESUS-MONKEYS; 4 SEROTYPES; IMMUNOGENICITY; INFECTION; SAFETY; FORMULATIONS AB Background. Protection against dengue requires immunity against all 4 serotypes of dengue virus (DENV). Experimental challenge may be useful in evaluating vaccine-induced immunity. Methods. Ten subjects previously vaccinated with a live attenuated tetravalent dengue vaccine (TDV) and 4 DENV-naive control subjects were challenged by subcutaneous inoculation of either 10(3) plaque-forming units (PFU) of DENV-1 or 10(5) PFU of DENV-3. Two additional subjects who did not develop DENV-3 neutralizing antibody (NAb) from TDV were revaccinated with 104 PFU of live attenuated DENV-3 vaccine to evaluate memory response. Results. All 5 TDV recipients were protected against DENV-1 challenge. Of the 5 TDV recipients challenged with DENV-3, 2 were protected. All DENV-3-challenge subjects who developed viremia also developed elevated liver enzyme levels, and 2 had values that were >10 times greater than normal. Of the 2 subjects revaccinated with DENV-3 vaccine, 1 showed a secondary response to DENV-2, while neither showed such response to DENV-3. All 4 control subjects developed dengue fever from challenge. Protection was associated with presence of NAb, although 1 subject was protected despite a lack of measurable NAb at the time of DENV-1 challenge. Conclusions. Vaccination with TDV induced variable protection against subcutaneous challenge. DENV-3 experimental challenge was associated with transient but marked elevations of transaminases. C1 [Sun, Wellington; Putnak, J. Robert; Lyons, Arthur G.; Thomas, Stephen J.; Vaughn, David W.; Gibbons, Robert V.; Fernandez, Stefan; Gunther, Vicky J.] Walter Reed Army Inst Res, Dept Virus Dis, Silver Spring, MD USA. [Eckels, Kenneth H.] Walter Reed Army Inst Res, Pilot Bioprod Facil, Silver Spring, MD USA. [Statler, John D.] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. [Innis, Bruce L.] GlaxoSmithKline, Vaccine Discovery & Dev, King Of Prussia, PA USA. [Mammen, Mammen P., Jr.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. RP Sun, W (reprint author), CBER, Div Vaccines & Related Prod Applicat, Off Vaccine Res & Review, 1451 Rock Ville Pike,Rm 2302, Rockville, MD 20852 USA. EM wellington.sun@fda.hhs.gov RI Lyons, Arthur/B-8923-2011 FU US Army Medical Research and Materiel Command FX This work was supported by the US Army Medical Research and Materiel Command. NR 41 TC 41 Z9 42 U1 0 U2 13 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD MAR 1 PY 2013 VL 207 IS 5 BP 700 EP 708 DI 10.1093/infdis/jis744 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 089FD UT WOS:000314894600002 PM 23225894 ER PT J AU Debboun, M Strickman, D AF Debboun, M. Strickman, D. TI Insect repellents and associated personal protection for a reduction in human disease SO MEDICAL AND VETERINARY ENTOMOLOGY LA English DT Review DE Individual prevention; insecticide-treated bednet; integrated pest management; malaria; mosquito; mosquito coil; public health; repellent; vector-borne disease ID DEET MOSQUITO REPELLENT; MALARIA CONTROL; AEDES-AEGYPTI; TREATED NETS; BED NETS; PREVENTION; VECTORS; EFFICACY; TRIAL; LEISHMANIASIS AB Personal protection measures against biting arthropods include topical insect repellents, area repellents, insecticide-treated bednets and treated clothing. The literature on the effectiveness of personal protection products against arthropods is mainly limited to studies of prevention of bites, rather than prevention of disease. Tungiasis was successfully controlled by application of topical repellents and scrub typhus was reduced through the use of treated clothing. Successful reduction of leishmaniasis was achieved through the use of topical repellents, treated bednets and treated clothing in individual studies. Malaria has been reduced by the use of insecticide-treated bednets (ITN), certain campaigns involving topical repellents, and the combination of treated bednets and topical repellents. Although area repellents such as mosquito coils are used extensively, their ability to protect humans from vector-transmitted pathogens has not been proven. Taken together, the literature indicates that personal protection measures must be used correctly to be effective. A study that showed successful control of malaria by combining treated bednets and topical repellents suggests that combinations of personal protection measures are likely to be more effective than single methods. Implementation of successful programmes based on personal protection will require a level of cooperation commonly associated with other basic societal functions, such as education and food safety. C1 [Debboun, M.] USA, Dept Prevent Hlth Serv, Acad Hlth Sci, Med Dept Ctr, Ft Sam Houston, TX USA. [Strickman, D.] ARS, Off Natl Programs, USDA, Beltsville, MD USA. RP Strickman, D (reprint author), ARS, USDA, Natl Program Staff, Room 4-2112,5601 Sunnyside Ave, Beltsville, MD 20705 USA. EM daniel.strickman@ars.usda.gov NR 61 TC 28 Z9 29 U1 1 U2 51 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0269-283X J9 MED VET ENTOMOL JI Med. Vet. Entomol. PD MAR PY 2013 VL 27 IS 1 BP 1 EP 9 DI 10.1111/j.1365-2915.2012.01020.x PG 9 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 091EU UT WOS:000315033000001 PM 22624654 ER PT J AU Jatapai, A Sirivongrangson, P Lokpichat, S Chuenchitra, T Nelson, KE Rangsin, R AF Jatapai, Anchalee Sirivongrangson, Pachara Lokpichat, Somchai Chuenchitra, Thippawan Nelson, Kenrad E. Rangsin, Ram TI Prevalence and Risk Factors for Chlamydia trachomatis Infection Among Young Thai Men in 2008-2009 SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID SEXUALLY-TRANSMITTED-DISEASES; NORTHERN THAILAND; HIV-INFECTION; BEHAVIOR; WOMEN; EPIDEMIOLOGY; TRANSMISSION; ADOLESCENTS; CONTEXT; ADULTS AB Background: Asymptomatic Chlamydia trachomatis (CT) infection and other sexually transmitted infections in men potentially contribute significantly in sustaining the spread of the infection. To describe the distribution and related sexual behaviors, we conducted a cross-sectional study among young Thai men using a (1: 30) systematic sampling of all newly inducted military conscripts in Thailand. Methods: In November 2008 and May 2009, participants' urine and serum samples were tested for CT and Neisseria gonorrhoeae, using a multiplex polymerase chain reaction technique, and serologic testing for Treponema pallidum and HIV-1 was done. Information on demographic data and risk behaviors was obtained by a self-administered questionnaire. Results: The overall prevalence rates of CT, N. gonorrhoeae, HIV-1, and syphilis infection were 7.9%, 0.9%, 0.5%, 0.05%, respectively. The risk factors for CT infection were living in the upper north region (adjusted rate ratios [95% confidence interval], 2.13 [1.39-3.26]), having had 4 or more sexual partners (2.14 [1.48-3.09]), graduation from a vocational school (1.66 [1.14-2.41]), inconsistent condom use (1.48 [1.05-2.08]), unemployment (1.82 [1.06-3.12]), and age 21 years or younger (1.63 [1.01-2.63]). Conclusions: The prevalence of CT infection among young male military conscripts was high, especially among men from upper northern Thailand. Multiple sexual partners, graduation from a vocational school, inconsistent condom use, unemployment before the military induction, and younger age were independently associated with the CT infection among young Thai men. These data will be useful to develop more effective public health interventions to prevent, detect, and treat sexually transmitted infections among young men in Thailand. C1 [Jatapai, Anchalee] Phramongkutklao Coll Med, Off Res & Dev, Bangkok 10400, Thailand. [Sirivongrangson, Pachara; Lokpichat, Somchai] Minist Publ Hlth, Dept Dis Control, Bur AIDS TB STIs, Bangkok, Thailand. [Chuenchitra, Thippawan] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Nelson, Kenrad E.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. [Rangsin, Ram] Phramongkutklao Coll Med, Dept Mil & Community Med, Bangkok 10400, Thailand. RP Rangsin, R (reprint author), Phramongkutklao Coll Med, Dept Mil & Community Med, 315 Ratchawithi Rd, Bangkok 10400, Thailand. EM rrangsin@pmk.ac.th FU National Institute of Health [5R01TW006972-04]; Ministry of Public Health, Thailand FX Supported by the National Institute of Health (No. 5R01TW006972-04) and Ministry of Public Health, Thailand. NR 27 TC 1 Z9 3 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD MAR PY 2013 VL 40 IS 3 BP 241 EP 246 DI 10.1097/OLQ.0b013e31827e8de4 PG 6 WC Infectious Diseases SC Infectious Diseases GA 089KY UT WOS:000314910600012 PM 23407469 ER PT J AU Convertino, M Baker, KM Vogel, JT Lu, C Suedel, B Linkov, I AF Convertino, M. Baker, K. M. Vogel, J. T. Lu, C. Suedel, B. Linkov, I. TI Multi-criteria decision analysis to select metrics for design and monitoring of sustainable ecosystem restorations SO ECOLOGICAL INDICATORS LA English DT Article DE Multi-criteria decision analysis; Environmental metrics; Ecosystem restoration; Monitoring; Stakeholder preferences, utility ID NETHERLANDS; FRAMEWORK; SCIENCE; WORLD; MODEL; RISK; ART AB The selection of metrics for ecosystem restoration programs is critical for improving the quality and utility of design and monitoring programs, informing adaptive management actions, and characterizing project success. The metrics selection process, that in practice is left to the subjective judgment of stakeholders, is often complex and should simultaneously take into account monitoring data, environmental models, socio-economic considerations, and stakeholder interests. With limited funding, it is often very difficult to balance the importance of multiple metrics, often competing, intended to measure different environmental, social, and economic aspects of the system. To help restoration planners and practitioners develop the most useful and informative design and monitoring programs, we propose the use of multi-criteria decision analysis (MCDA) methods, broadly defined, to select optimal ecosystem restoration metric sets. In this paper, we apply and compare two MCDA methods, multi-attribute utility theory (MAUT), and probabilistic multi-criteria acceptability analysis (ProMAA), for a hypothetical river restoration case study involving multiple stakeholders with competing interests. Overall, the MCDA results in a systematic, quantitative, and transparent evaluation and comparison of potential metrics that provides planners and practitioners with a clear basis for selecting the optimal set of metrics to evaluate restoration alternatives and to inform restoration design and monitoring. In our case study, the two MCDA methods provide comparable results in terms of selected metrics. However, because ProMAA can consider probability distributions for weights and utility values of metrics for each criterion, it is most likely the best option for projects with highly uncertain data and significant stakeholder involvement. Despite the increase in complexity in the metrics selection process, MCDA improves upon the current, commonly-used ad-hoc decision practice based on consultations with stakeholders by applying and presenting quantitative aggregation of data and judgment, thereby increasing the effectiveness of environmental design and monitoring and the transparency of decision making in restoration projects. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Convertino, M.] Univ Florida, Dept Agr & Biol Engn, Gainesville, FL USA. [Convertino, M.] Univ Florida, Florida Climate Inst, Gainesville, FL USA. [Baker, K. M.; Vogel, J. T.] USA, Corps Engineers, Risk & Decis Sci Team, Environm Lab,ERDC, Concord, MA USA. [Lu, C.] MIT, Dept Civil & Environm Engn, Environm & Water Qual Program, Cambridge, MA 02139 USA. [Suedel, B.; Linkov, I.] USA, Corps Engineers, Risk & Decis Sci Team, Environm Lab,ERDC, Vicksburg, MS 39180 USA. [Linkov, I.] Carnegie Mellon Univ, Dept Engn & Publ Policy, Pittsburgh, PA 15213 USA. RP Convertino, M (reprint author), Dept Agr & Biol Engn, Frazier Rogers Hall,Museum Rd,POB 110570, Gainesville, FL 32611 USA. EM mconvertino@ufl.edu FU Environmental Benefit Analysis Program of the U.S. Army Corps of Engineers; DECERNS-SDSS; Engineering Research and Development Center, U.S. Army Corps of Engineers, in Concord, MA, USA FX The authors acknowledge the support of the Environmental Benefit Analysis Program of the U.S. Army Corps of Engineers (http://cw-environment.usace.army.mil/eba/). Dr. B. Yatsalo is acknowledged for making a demonstration version of DECERNS-SDSS available. D. Dokukin, and J.M. Keisler are kindly acknowledged for their support with DECERNS-SDSS and for the basis of the theoretical framework respectively. The Editor, Dr. F. Muller and two anonymous reviewers are gratefully acknowledged for their constructive comments. M.C. acknowledges the funding of project "Decision and Risk Analysis Applications Environmental Assessment and Supply Chain Risks" for his research at the Risk and Decision Science Team, Engineering Research and Development Center, U.S. Army Corps of Engineers, in Concord, MA, USA. C. Lu was BSc and MSc student at Massachusetts Institute of Technology, and research intern at the Risk and Decision Science Group when this research was performed. C. Lu is currently at AMEC Environment & Infrastructure, Oakland, CA. Permission was granted by the U.S. Army Corps of Engineers - Chief of Engineers to publish this material. The views and opinions expressed in this paper are those of the individual authors and not those of the U.S. Army, or other sponsoring organizations. NR 56 TC 19 Z9 20 U1 3 U2 85 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1470-160X EI 1872-7034 J9 ECOL INDIC JI Ecol. Indic. PD MAR PY 2013 VL 26 BP 76 EP 86 DI 10.1016/j.ecolind.2012.10.005 PG 11 WC Biodiversity Conservation; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 083RP UT WOS:000314483200009 ER PT J AU Goswami, R Holtz, RL AF Goswami, Ramasis Holtz, Ronald L. TI Transmission Electron Microscopic Investigations of Grain Boundary Beta Phase Precipitation in Al 5083 Aged at 373 K (100 degrees C) SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE LA English DT Article; Proceedings Paper CT International Symposium on the Environmental Damage under Static and Cyclic Loads in Structural Materials at Ambient Temperatures-II CY AUG 14-19, 2011 CL Krakow, POLAND ID STRESS-CORROSION CRACKING; SENSITIZED AA5083 AL-4.5MG-1.0MN; MG ALLOY; ALUMINUM-ALLOYS; STRENGTHENING MECHANISMS; INTERGRANULAR CORROSION; SEGREGATION; DIFFUSION; PARTICLES AB The fine-scale microstructure of an Al 5083 alloy sensitized at 373 K (100 A degrees C) for 3, 7, 14, 30, 45, and 90 days has been investigated using transmission electron microscopy (TEM) to study the evolution of the beta phase (Al3Mg2) at grain boundaries. In fully sensitized Al 5083, the beta phase (Al3Mg2) mostly forms heterogeneously at grain boundaries. TEM observations showed that the grain boundary precipitation of beta phase was discrete up to 14 days of aging, and grain boundaries were fully covered by the beta phase after 30 to 45 days of aging. The early stages of beta growth on the grain boundaries are consistent with the collector-plate mechanism. We find no evidence of either Mg depletion or segregation at the grain boundaries. The initial growth rates as well as the thicknesses after long aging times are greater than can be accounted for by bulk diffusion of Mg to the grain boundaries. We suggest that dislocation pipe diffusion is necessary to account for the beta growth rates. C1 [Goswami, Ramasis; Holtz, Ronald L.] USA, Res Lab, Washington, DC 20375 USA. RP Goswami, R (reprint author), USA, Res Lab, Code 6351,4555 Overlook Ave SW, Washington, DC 20375 USA. EM Ramasis.goswami@nrl.navy.mil NR 48 TC 26 Z9 28 U1 3 U2 34 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1073-5623 EI 1543-1940 J9 METALL MATER TRANS A JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci. PD MAR PY 2013 VL 44A IS 3 BP 1279 EP 1289 DI 10.1007/s11661-012-1166-9 PG 11 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 082BK UT WOS:000314366500013 ER PT J AU Collins, PC Koduri, S Welk, B Tiley, J Fraser, HL AF Collins, Peter C. Koduri, Santhosh Welk, Brian Tiley, Jaimie Fraser, Hamish L. TI Neural Networks Relating Alloy Composition, Microstructure, and Tensile Properties of alpha/beta-Processed TIMETAL 6-4 SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE LA English DT Article; Proceedings Paper CT International Symposium on the Environmental Damage under Static and Cyclic Loads in Structural Materials at Ambient Temperatures-II CY AUG 14-19, 2011 CL Krakow, POLAND ID TITANIUM-ALLOYS; MECHANICAL-PROPERTIES; STRENGTH; GROWTH; STEELS; EQUILIBRIUM; TI-6AL-4V; WELDS AB Bayesian neural networks have been developed, which relate composition, microstructure, and tensile properties of the alloy TIMETAL 6-4 (nominal composition: Ti-6Al-4V (wt pct) after thermomechanical processing (TMP) in the two-phase (alpha + beta)-phase field. The developed networks are able to make interpolative predictions of properties within the ranges of composition and microstructural features that are in the population of the database used for training and testing of the networks. In addition, the neural networks have been used to conduct virtual experiments which permit the functional dependencies of properties on composition and microstructural features to be determined. In this way, it is shown that in the microstructural condition resulting from TMP in the two-phase (alpha + beta) phase field, the most significant contribution to strength is from solid solution strengthening, with microstructural features apparently influencing the balance of a number of properties. C1 [Collins, Peter C.; Koduri, Santhosh; Welk, Brian; Fraser, Hamish L.] Ohio State Univ, Dept Mat Sci & Engn, Columbus, OH 43210 USA. [Tiley, Jaimie] USA, Mat & Mfg Directorate, Res Lab, Dayton, OH USA. RP Collins, PC (reprint author), Univ N Texas, Dept Mat Sci & Engn, Denton, TX 76203 USA. EM Peter.Collins@unt.edu RI Collins, Peter/A-4961-2016 OI Collins, Peter/0000-0002-3441-2981 FU Air Force Research Laboratory; Office of Naval Research; Metals Affordability Initiative ("Microstructural and Mechanical Property Model Development for Wrought Titanium Alloys"); ONR/DARPA D-3D Program [N00014-05-1-0504] FX The authors of this article would like to express their thanks to the Air Force Research Laboratory and the Office of Naval Research for their funding of the research programs which supported the current research, including specifically the Metals Affordability Initiative ("Microstructural and Mechanical Property Model Development for Wrought Titanium Alloys") and the ONR/DARPA D-3D Program ("Experimental and computational tools for the digital representation and prediction of microstructure and its incorporation in the designer's knowledge base," N00014-05-1-0504) which have led to the development of these databases and neural networks. The authors would also like to thank the many graduate students associated with the Center for the Accelerated Maturation of Materials (CAMM) who characterized the material which has been included in the databases. NR 39 TC 11 Z9 11 U1 2 U2 28 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1073-5623 EI 1543-1940 J9 METALL MATER TRANS A JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci. PD MAR PY 2013 VL 44A IS 3 BP 1441 EP 1453 DI 10.1007/s11661-012-1498-5 PG 13 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 082BK UT WOS:000314366500028 ER PT J AU Olson, MA Lee, MS AF Olson, Mark A. Lee, Michael S. TI Structure refinement of protein model decoys requires accurate side-chain placement SO PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS LA English DT Article DE protein structure prediction; conformational sampling; Langevin dynamics; molecular dynamics; statistical potential; structure recognition ID MOLECULAR-DYNAMICS SIMULATIONS; GUIDED LANGEVIN DYNAMICS; HIGH-RESOLUTION REFINEMENT; I-TASSER; REPLICA-EXCHANGE; STATISTICAL POTENTIALS; STRUCTURE PREDICTION; HOMOLOGY MODELS; FORCE; CASP9 AB In this study, the application of temperature-based replica-exchange (T-ReX) simulations for structure refinement of decoys taken from the I-TASSER dataset was examined. A set of eight nonredundant proteins was investigated using self-guided Langevin dynamics (SGLD) with a generalized Born implicit solvent model to sample conformational space. For two of the protein test cases, a comparison of the SGLD/T-ReX method with that of a hybrid explicit/implicit solvent molecular dynamics T-ReX simulation model is provided. Additionally, the effect of side-chain placement among the starting decoy structures, using alternative rotamer conformations taken from the SCWRL4 modeling program, was investigated. The simulation results showed that, despite having near-native backbone conformations among the starting decoys, the determinant of their refinement is side-chain packing to a level that satisfies a minimum threshold of native contacts to allow efficient excursions toward the downhill refinement regime on the energy landscape. By repacking using SCWRL4 and by applying the RWplus statistical potential for structure identification, the SGLD/T-ReX simulations achieved refinement to an average of 38% increase in the number of native contacts relative to the original I-TASSER decoy sets and a 25% reduction in values of Ca root-mean-square deviation. The hybrid model succeeded in obtaining a sharper funnel to low-energy states for a modeled target than the implicit solvent SGLD model; yet, structure identification remained roughly the same. Without meeting a threshold of near-native packing of side chains, the T-ReX simulations degrade the accuracy of the decoys, and subsequently, refinement becomes tantamount to the protein folding problem. Proteins 2013. 2012 Published by Wiley Periodicals, Inc. C1 [Olson, Mark A.; Lee, Michael S.] USAMRIID, Dept Cell Biol & Biochem, Frederick, MD 21702 USA. [Lee, Michael S.] USAMRIID, Ctr Genome Sci, Frederick, MD 21702 USA. [Lee, Michael S.] USA, Computat Sci & Engn Branch, Res Lab, Aberdeen, MD 21005 USA. RP Olson, MA (reprint author), USAMRIID, Dept Cell Biol & Biochem, Frederick, MD 21702 USA. EM molson@compbiophys.org FU U.S. Department of Defense Threat Reduction Agency [TMTI0004_09_714_BH_T, CBCALL12-LS6-2-0036] FX Grant sponsor: U.S. Department of Defense Threat Reduction Agency; Grant numbers: TMTI0004_09_714_BH_T, CBCALL12-LS6-2-0036 NR 35 TC 8 Z9 8 U1 0 U2 17 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0887-3585 J9 PROTEINS JI Proteins PD MAR PY 2013 VL 81 IS 3 BP 469 EP 478 DI 10.1002/prot.24204 PG 10 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 079OI UT WOS:000314179600010 PM 23070940 ER PT J AU Webb, CM Estrada, A Athy, JR AF Webb, Catherine M. Estrada, Arthur Athy, Jeremy R. TI Motion Sickness Prevention by an 8-Hz Stroboscopic Environment During Air Transport SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE Motion sickness; stroboscopic; airsickness; retinal slip ID SLEEP-DEPRIVATION; EXPOSURE; VISION AB Introduction: Previous research has shown that retinal slip can be a significant factor in causing motion sickness. Stroboscopic illumination may prevent retinal slip by providing snapshots of the visual environment that are brief enough so each image is stationary on the retina. Methods: The purpose of this study was to determine the effectiveness of an 8-Hz stroboscopic environment as a motion sickness countermeasure for passengers during a nauseogenic flight in a helicopter. The study population was comprised of 18 motion sickness susceptible subjects. Subjects completed a motion sickness symptom questionnaire, a psychomotor vigilance test, weapons utilization tasks, a time estimation task, and a sustained attention task after nauseogenic flights with and without 8-Hz stroboscopic illumination in the cabin. Results: Baseline-corrected scores of self-reported nausea were significantly lower after the stroboscopic condition (M = 36.57 +/- 6.95) than the nonstroboscopic condition (M = 50.88 +/- 7.36). Furthermore, the stroboscopic condition resulted in significantly better performance on the vigilance task than the nonstroboscopic condition. However, baseline-corrected scores of oculomotor symptoms were greater after the stroboscopic condition (M = 33.27 +/- 5.52) than the nonstroboscopic condition (M = 24.85 +/- 4.10). Discussion: These results support the use of stroboscopic illumination as a nonpharmacologic countermeasure for motion sickness related to retinal slip. However, due to the uncontrolled nature of the flights, the possibility that these results could have been influenced by differences in motion between flights cannot be excluded. This technology should be investigated in other forms of transportation (i.e., ground vehicles). C1 [Webb, Catherine M.; Estrada, Arthur; Athy, Jeremy R.] US Army, Aeromed Res Lab, Fort Rucker, AL 36362 USA. RP Webb, CM (reprint author), US Army, Aeromed Res Lab, POB 620577, Fort Rucker, AL 36362 USA. EM catherine.webb@us.army.mil FU Army Medical Department Advanced Medical Technology Initiative (AAMTI) from the Telemedicine and Advanced Technology Research Center (TATRC) FX This study was funded by the Army Medical Department Advanced Medical Technology Initiative (AAMTI) from the Telemedicine and Advanced Technology Research Center (TATRC). The opinions, interpretations, conclusions, and recommendations contained in this report are those of the authors and should not be construed as an official Department of the Army position, policy, or decision, unless so designated by other official documentation. Citation of trade names in this report does not constitute an official Department of the Army endorsement or approval of the use of such commercial items. NR 23 TC 3 Z9 4 U1 0 U2 5 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 EI 1943-4448 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD MAR PY 2013 VL 84 IS 3 BP 177 EP 183 DI 10.3357/ASEM.3342.2013 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA AD1LP UT WOS:000332995800001 PM 23513277 ER PT J AU Jennings, NA AF Jennings, Nathan A. TI Riding into Controversy: A Study in Contrasting Views of the Texas Rangers SO JOURNAL OF THE WEST LA English DT Article RP Jennings, NA (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 39 TC 0 Z9 0 U1 0 U2 0 PU ABC-CLIO PI SANTA BARBARA PA 130 CREMONA DR, SANTA BARBARA, CA 93117 USA SN 0022-5169 EI 1930-0115 J9 J WEST JI J. West PD SPR PY 2013 VL 52 IS 2 BP 42 EP 52 PG 11 WC History SC History GA V39AM UT WOS:000209383900006 ER PT J AU Dai, TH Gupta, A Huang, YY Yin, R Murray, C Vrahas, M Kielian, T Hamblin, M AF Dai, Tianhong Gupta, Asheesh Huang, Yingying Yin, Rui Murray, Clinton Vrahas, Mark Kielian, Tammy Hamblin, Michael TI BLUE LIGHT ELIMINATES COMMUNITY-ACQUIRED METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS IN INFECTED MOUSE SKIN ABRASIONS SO LASERS IN SURGERY AND MEDICINE LA English DT Meeting Abstract C1 Harvard Univ, Massachusetts Gen Hosp, Sch Med, Wellman Ctr Photomed, Boston, MA USA. Brooke Army Med Ctr, Infect Dis Serv, Houston, TX USA. Univ Nebraska Med Ctr, Omaha, NE USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0196-8092 EI 1096-9101 J9 LASER SURG MED JI Lasers Surg. Med. PD MAR PY 2013 VL 45 SU 25 MA 121 BP 41 EP 41 PG 1 WC Dermatology; Surgery SC Dermatology; Surgery GA V38YX UT WOS:000209379800116 ER PT J AU Terrill, WA AF Terrill, W. Andrew TI A Quietist Jihadi: The Ideology and Influence of Abu Muhammad al-Maqdisi SO MIDDLE EAST JOURNAL LA English DT Book Review C1 [Terrill, W. Andrew] US Army War Coll, Strateg Studies Inst, Carlisle, PA USA. RP Terrill, WA (reprint author), US Army War Coll, Strateg Studies Inst, Carlisle, PA USA. NR 1 TC 0 Z9 0 U1 1 U2 1 PU MIDDLE EAST INST PI WASHINGTON PA 1761 N ST NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 USA SN 0026-3141 J9 MIDDLE EAST J JI Middle East J. PD SPR PY 2013 VL 67 IS 2 BP 332 EP 333 PG 2 WC Area Studies SC Area Studies GA AG2UT UT WOS:000335273300024 ER PT J AU Radomski, MV Weightman, MM Davidson, LF Finkelstein, M Goldman, S McCulloch, K Roy, TC Scherer, M Stern, EB AF Radomski, Mary Vining Weightman, Margaret M. Davidson, Leslie Freeman Finkelstein, Marsha Goldman, Sarah McCulloch, Karen Roy, Tanja C. Scherer, Matthew Stern, Erica B. TI Development of a Measure to Inform Return-to-Duty Decision Making After Mild Traumatic Brain Injury SO MILITARY MEDICINE LA English DT Article ID ECOLOGICAL VALIDITY; POSTURAL STABILITY; COGNITIVE TASKS; CONCUSSION; GAIT; PERFORMANCE; ATTENTION; RECOVERY; DEFICITS; INTERFERENCE AB Mild traumatic brain injury (mTBI), a principal injury of the wars in Iraq and Afghanistan, can result in significant morbidity. To make accurate return-to-duty decisions for soldiers with mTBI, military medical personnel require sensitive, objective, and duty-relevant data to characterize subtle cognitive and sensorimotor injury sequelae. A military-civilian research team reviewed existing literature and obtained input from stakeholders, end users, and experts to specify the concept and develop a preliminary assessment protocol to address this need. Results of the literature review suggested the potential utility of a test based on dual-task and multitask assessment methods. Thirty-three individuals representing a variety of military and civilian stakeholders/experts participated in interviews. Interview data suggested that reliability/validity, clinical feasibility, usability across treatment facilities, military face validity, and capacity to challenge mission-critical mTBI vulnerabilities were important to ultimate adoption. The research team developed the Assessment of Military Multitasking Performance, a tool composed of eight dual and multitasking test-tasks. A concept test session with 10 subjects indicated preliminary face validity and informed modifications to scoring and design. Further validation is needed. The Assessment of Military Multitasking Performance may fill a gap identified by stakeholders for complex cognitive/motor testing to assist return-to-duty decisions for service members with mTBI. C1 [Radomski, Mary Vining; Weightman, Margaret M.; Finkelstein, Marsha] Sister Kenny Res Ctr, Minneapolis, MN 55407 USA. [Davidson, Leslie Freeman] Shenandoah Univ, Div Occupat Therapy, Winchester, VA 22601 USA. [Goldman, Sarah; Roy, Tanja C.; Scherer, Matthew] US Army Res Inst Environm Med, Natick, MA 01760 USA. [McCulloch, Karen] Univ N Carolina, Sch Med, Div Phys Therapy, Chapel Hill, NC 27599 USA. [Stern, Erica B.] Univ Minnesota, Ctr Allied Hlth Programs, Program Occupat Therapy, Minneapolis, MN 55455 USA. RP Radomski, MV (reprint author), Sister Kenny Res Ctr, 800 East 28th St & Chicago Ave, Minneapolis, MN 55407 USA. FU U.S. Army Medical Research and Materiel Command [W81XWH-09-2-0149] FX The research team acknowledges the contribution of those interviewed and the following partners and experts who have helped to shape the AMMP protocol: Amanda Antczalc, MS; Kristin Heaton, PhD; Val Kelly PT, PhD; Lynne M. Lowe, PT, DPT, OCS; Tracy Morrison, OTD, OTR/L; Lars Oddsson, PhD; John Whyte, MD, PhD; and Tim Wolf, OTD, MSCI, OTR/L. This project was funded by the U.S. Army Medical Research and Materiel Command (award number W81XWH-09-2-0149). NR 48 TC 6 Z9 6 U1 2 U2 7 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2013 VL 178 IS 3 BP 246 EP 253 DI 10.7205/MILMED-D-12-00144 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA AN7TX UT WOS:000340805000003 PM 23707109 ER PT J AU Gallaway, MS Bell, MR Lagana-Riordan, C Fink, DS Meyer, CE Millikan, AM AF Gallaway, M. Shayne Bell, Michael R. Lagana-Riordan, Christine Fink, David S. Meyer, Charles E. Millikan, Amy M. TI The Association Between US Army Enlistment Waivers and Subsequent Behavioral and Social Health Outcomes and Attrition From Service SO MILITARY MEDICINE LA English DT Article AB Soldiers granted enlistment waivers for medical concerns, misconduct, or positive alcohol/drug tests may or may not be associated with an increased likelihood of negative behavioral outcomes. Soldiers in the population examined (n = 8,943) who were granted enlistment waivers from 2003 to 2008 were significantly more likely to subsequently be screened for alcohol/substance abuse, test positive for illicit substances, or receive an Army separation for behavioral misconduct. These associations were highest among Soldiers granted waivers for nonlawful alcohol/drug violations. Soldiers granted waivers for felony offenses and serious nontraffic violations were significantly less likely to separate from the Army compared with Soldiers not granted enlistment waivers. C1 [Gallaway, M. Shayne; Lagana-Riordan, Christine; Fink, David S.; Meyer, Charles E.; Millikan, Amy M.] US Army, Inst Publ Hlth, Behav & Social Hlth Outcomes Program, Aberdeen Proving Ground, MD 21010 USA. [Bell, Michael R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Gallaway, MS (reprint author), US Army, Inst Publ Hlth, Behav & Social Hlth Outcomes Program, 5158 Blacichawk Rd,Bldg E-1570, Aberdeen Proving Ground, MD 21010 USA. OI Fink, David/0000-0003-1531-1525 NR 20 TC 4 Z9 4 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2013 VL 178 IS 3 BP 261 EP 266 DI 10.7205/MILMED-D-12-00316 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA AN7TX UT WOS:000340805000005 PM 23707111 ER PT J AU Moore, AD Hamilton, JB Pierre-Louis, BJ Jennings, BM AF Moore, Angelo D. Hamilton, Jill B. Pierre-Louis, Bosny J. Jennings, Bonnie M. TI Increasing Access to Care and Reducing Mistrust: Important Considerations When Implementing the Patient-Centered Medical Home in Army Health Clinics SO MILITARY MEDICINE LA English DT Article ID MENTAL-HEALTH; SATISFACTION; VETERANS; DISCRIMINATION; RELIGION; BELIEFS; SUPPORT; RACISM; MODEL AB Objective: To determine which individual characteristics (religious participation, mistrust, racism/discrimination, spirituality, perceived access to care, and continuity of care) were predictors of patient outcomes (patient satisfaction, physical health, and mental health status) for an Army health care clinic transitioning to the Patient-Centered Medical Home (PCMH). Method: A descriptive, correlational design using stepwise multivariate regression analyses to assess the effect of individual characteristics on patient outcomes for 200 Army Soldiers and family members receiving health care services. Results: Perceived access to care was positively and mistrust was negatively related to patient satisfaction (p < 0.001 for both variables). Participants who reported more support from God and more mistrust also reported poorer physical health status (p < 0.008 and p < 0.003, respectively). Perceived access to care was the only individual characteristic that showed a significant (p < 0.019) positive association with a better mental health status. Conclusion: This study suggests that better access to care improves patient satisfaction and mental health status; however, those with higher levels of mistrust tend to have lower patient satisfaction and poorer health. Participants with poorer health also tend to rely on more support from God. These important individual characteristics should be the considered when implementing the PCMH. C1 [Moore, Angelo D.] Tripler Army Med Ctr, Ctr Nursing Sci & Clin Inquiry, Honolulu, HI 96859 USA. [Hamilton, Jill B.] Univ N Carolina, Sch Nursing, Chapel Hill, NC 27599 USA. [Pierre-Louis, Bosny J.] Nov Analyt, Durham, NC 27713 USA. [Jennings, Bonnie M.] Emory Univ, Nell Hodgson Woodruff Sch Nursing, Atlanta, GA 30322 USA. RP Moore, AD (reprint author), Tripler Army Med Ctr, Ctr Nursing Sci & Clin Inquiry, 1 Jarrett White Rd, Honolulu, HI 96859 USA. FU TriService Nursing Research Program, Uniformed Services University of the Health Sciences [N11-P05] FX We thank Jessica L. Krusel for her assistance in this research project. We also thank the leadership and staff at the clinic and Exchange (formally Army Air Force Exchange Services) for assisting with obtaining all necessary approvals and accommodating sites needed for recruiting participants for this research study. This research study was funded by the TriService Nursing Research Program (grant N11-P05), Uniformed Services University of the Health Sciences. NR 42 TC 5 Z9 5 U1 2 U2 6 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2013 VL 178 IS 3 BP 291 EP 298 DI 10.7205/MILMED-D-12-00443 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA AN7TX UT WOS:000340805000010 PM 23707116 ER PT J AU Bastian, ND Brown, D Fulton, LV Mitchell, R Pollard, W Robinson, M Wilson, R AF Bastian, Nathaniel D. Brown, David Fulton, Lawrence V. Mitchell, Robert Pollard, Wayne Robinson, Mark Wilson, Ronald TI Analyzing the Future of Army Aeromedical Evacuation Units and Equipment: A Mixed Methods, Requirements-Based Approach SO MILITARY MEDICINE LA English DT Article AB We utilize a mixed methods approach to provide three new, separate analyses as part of the development of the next aeromedical evacuation (MEDEVAC) platform of the Future of Vertical Lift (FVL) program. The research questions follow: RQ1) What are the optimal capabilities of a FVL MEDEVAC platform given an Afghanistan-like scenario and parameters associated with the treatment/ground evacuation capabilities in that theater?; RQ2) What are the MEDEVAC trade-off considerations associated with different aircraft engines operating under variable conditions?; RQ3) How does the additional weight of weaponizing the current MEDEVAC fleet affect range, coverage radius, and response time? We address RQ1 using discrete-event simulation based partially on qualitative assessments from the field, while RQ2 and RQ3 are based on deterministic analysis. Our results confirm previous findings that travel speeds in excess of 250 knots and ranges in excess of 300 nautical miles are advisable for the FVL platform design, thereby reducing the medical footprint in stability operations. We recommend a specific course of action regarding a potential engine bridging strategy based on deterministic analysis of endurance and altitude, and we suggest that the weaponization of the FVL MEDEVAC aircraft will have an adverse effect on coverage capability. C1 [Bastian, Nathaniel D.] US Army Med Dept Ctr & Sch, Ctr AMEDD Strateg Studies, Med Capabil Integrat Ctr, Ft Sam Houston, TX 78234 USA. [Brown, David; Pollard, Wayne; Wilson, Ronald] Navigator Dev Grp Inc, Enterprise, AL 36330 USA. [Fulton, Lawrence V.] Texas State Univ, McCoy Coll Business Adm, Dept Comp Informat Syst & Quantitat Methods, San Marcos, TX 78666 USA. [Robinson, Mark] US Army Med Dept Ctr & Sch, Med Capabil Integrat Ctr, Med Evacuat Proponency Directorate, Ft Rucker, AL 36362 USA. RP Bastian, ND (reprint author), US Army Med Dept Ctr & Sch, Ctr AMEDD Strateg Studies, Med Capabil Integrat Ctr, 1608 Stanley Rd, Ft Sam Houston, TX 78234 USA. FU Medical Evacuation Proponency Directorate of the Medical Capabilities Integration Center of the U.S. Army Medical Department Center School FX We thank the Medical Evacuation Proponency Directorate of the Medical Capabilities Integration Center of the U.S. Army Medical Department Center & School who funded the research and analysis of this study. NR 14 TC 5 Z9 5 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2013 VL 178 IS 3 BP 321 EP 329 DI 10.7205/MILMED-D-12-00370 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA AN7TX UT WOS:000340805000014 PM 23707120 ER PT J AU Aaron, CL Fotinos, MJ West, KB Goodwin, DJ Mancuso, JD AF Aaron, Christopher L. Fotinos, Meletios J. West, Kevin B. Goodwin, Donald J. Mancuso, James D. TI Tuberculosis Among Nonimmigrant Visitors to US Military Installations SO MILITARY MEDICINE LA English DT Article ID FOREIGN-BORN PERSONS; UNITED-STATES AB Background: Nonimmigrant visitors are not required to be evaluated for tuberculosis (TB) before entering the country. Little literature exists describing the challenges of TB control among this demographic. This report reviews the challenges in managing TB in this population on U.S. military installations. Methods: Six cases were identified from reportable medical event reports. Information was obtained from public health personnel via phone interviews. Verified cases from 2004 to 2011 were included. Results: Challenges were congruent among locations including: lack of procedures to screen for infection and disease among individuals at time of entry allowing one case to be admitted with acquired immunodeficiency syndrome and another concurrently on treatment for active TB; delays in the diagnosis of active TB as median time from entry to diagnosis was 62 days; and the need to conduct an effective contact investigation as the mean contact index was 77 including 1 secondary case of active TB. Conclusions: These cases emphasize the, need for screening for TB in visitors from high-risk countries at time of entry, prompt diagnosis and treatment if found, procedures for evaluation of contacts, and interjurisdictional cooperation in large contact investigations. These challenges are common to nonimmigrants in both military and civilian settings. C1 [Aaron, Christopher L.] Walter Reed Army Inst Res, Prevent Med Branch, Silver Spring, MD 20910 USA. [Fotinos, Meletios J.] Global Hlth Engagement Branch AFMSA SGXI, Lackland AFB, TX 78236 USA. [West, Kevin B.] Wilford Hall USAF Med Ctr, Reid Clin, Lackland AFB, TX 78236 USA. [Goodwin, Donald J.] USAF Sch Aerosp Med, Wright Patterson AFB, OH 45433 USA. [Mancuso, James D.] Walter Reed Army Inst Res, Prevent Med Branch, Silver Spring, MD 20910 USA. RP Aaron, CL (reprint author), Walter Reed Army Inst Res, Prevent Med Branch, 2460 Linden Lane,Bldg 509,Off 110, Silver Spring, MD 20910 USA. FU Preventive Medicine Residency [11]; Walter Reed Army Institute of Research, Silver Spring, Maryland FX This study was funded by Preventive Medicine Residency, Program 11, Walter Reed Army Institute of Research, Silver Spring, Maryland. NR 13 TC 2 Z9 2 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2013 VL 178 IS 3 BP 346 EP 352 DI 10.7205/MILMED-D-12-00297 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA AN7TX UT WOS:000340805000018 PM 23707124 ER PT J AU Smith, R AF Smith, Roger TI Wild West Innovation SO RESEARCH-TECHNOLOGY MANAGEMENT LA English DT Editorial Material C1 [Smith, Roger] Florida Hosp, Nicholson Ctr Surg Adv, Orlando, FL 32803 USA. [Smith, Roger] US Army Simulat, Orlando, FL USA. [Smith, Roger] Titan Corp, San Diego, CA USA. [Smith, Roger] BTG Inc, Jacksonville, FL USA. RP Smith, R (reprint author), Florida Hosp, Nicholson Ctr Surg Adv, Orlando, FL 32803 USA. EM roger.smith@flhosp.org NR 1 TC 0 Z9 0 U1 0 U2 0 PU INDUSTRIAL RESEARCH INST, INC PI ARLINGTON PA 2200 CLARENDON BLVD, STE 1102, ARLINGTON, VA 22201 USA SN 0895-6308 EI 1930-0166 J9 RES TECHNOL MANAGE JI Res.-Technol. Manage. PD MAR-APR PY 2013 VL 56 IS 2 BP 56 EP 57 DI 10.5437/08956308X5602007 PG 2 WC Business; Engineering, Industrial; Management SC Business & Economics; Engineering GA AI8XO UT WOS:000337210500012 ER PT J AU Burns, DS Cory, MG Taylor, DE Bunte, SW Runge, K Vasey, JL AF Burns, Douglas S. Cory, Marshall G. Taylor, Decarlos E. Bunte, Steven W. Runge, Keith Vasey, Joseph L. TI A Comparison of Primary and Secondary Hydrogen Abstraction from Organophosphates by Hydroxyl Radical SO INTERNATIONAL JOURNAL OF CHEMICAL KINETICS LA English DT Article ID GAS-PHASE REACTIONS; DIRECT DYNAMICS CALCULATIONS; MOLECULAR-ORBITAL METHODS; ATMOSPHERIC CHEMISTRY; TRIETHYL PHOSPHATE; RATE CONSTANTS; OH RADICALS; METHYLPHOSPHONATE; SURFACES; KINETICS AB To compare the effect of primary and secondary C?H bonds on hydrogen?atom abstraction by hydroxyl radical, rate constants for the reactions of OH radicals with trimethyl phosphate [TMPO, (CH3O)3P(O)] and triethyl phosphate [TEPO, (CH3CH2O)3P(O)] have been calculated using the semiclassical fluxflux autocorrelation function (SCFFAF) method and compared with experimental measurements over the temperature range 250350K. SCFFAF specifies that structures be obtained at the CCSD/6?31++G** level of chemical theory and the height of the activation barrier be determined using an energy extrapolation, here a variant of the G2MP2 method. Dynamics are generated in the SCFFAF method from forces computed with a transfer Hamiltonian, which provides information about the curvature of the potential energy surface in the neighborhood of the transition state (TS), as well as the required internal forces. The temperature?dependent reaction rate constants are calculated for the various possible abstraction pathways, primary hydrogen atom abstraction in the case of TMPO, and primary and secondary in the case of TEPO. Since two energetically favorable parent structures for each system are included in the model, the activation energy is calculated with respect to the conformer that connects to a given TS and the total rate constant at a given temperature is Boltzmann weighted with respect to the parent conformer. The computed temperature?dependent rate curves are consistent with published experimental data in both magnitude and temperature dependence. (C) 2013 Wiley Periodicals, Inc. Int J Chem Kinet 45: 187201, 2013 C1 [Burns, Douglas S.; Cory, Marshall G.; Vasey, Joseph L.] ENSCO Inc, Melbourne, FL 32940 USA. [Taylor, Decarlos E.; Bunte, Steven W.] USA, Res Lab, Weap & Mat Res Directorate, RDRL WMB D, Aberdeen Proving Ground, MD 21005 USA. [Runge, Keith] BWD Associates LLC, Gainesville, FL 32653 USA. RP Burns, DS (reprint author), ENSCO Inc, Melbourne, FL 32940 USA. EM burns.douglas@ensco.com FU U.S. Air Force FX This work was supported by the U.S. Air Force. NR 36 TC 3 Z9 3 U1 0 U2 28 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0538-8066 EI 1097-4601 J9 INT J CHEM KINET JI Int. J. Chem. Kinet. PD MAR PY 2013 VL 45 IS 3 BP 187 EP 201 DI 10.1002/kin.20755 PG 15 WC Chemistry, Physical SC Chemistry GA 076WY UT WOS:000313991100006 ER PT J AU Nie, X Sanborn, B Weerasooriya, T Chen, WN AF Nie, Xu Sanborn, Brett Weerasooriya, Tusit Chen, Weinong TI High-rate bulk and shear responses of bovine brain tissue SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Brain tissue; High strain rate; Shear response; Rate effects; Kolsky bar ID ELASTOHYDRODYNAMIC LUBRICANTS; MECHANICAL-BEHAVIOR; SOFT MATERIALS; COMPRESSIBILITY; INERTIA; TIME AB This experimental study systematically investigates the dynamic response of bovine brain tissue under uniaxial strain and pure shear loading conditions. The combination of such stress states and strain rates are representative in the brain under blast loading in which both bulk and shear deformation may be involved. The dynamic uniaxial strain experiments (bulk response) were conducted on a modified Kolsky compression bar with an aluminum confinement collar. Bovine brain samples were sealed in the collar and loaded by the Kolsky bars so that the specimen only deformed in the axial direction. The resultant stress-strain curves reflected the pressure-volume relations from which the bulk modulus were obtained. The dynamic shear response was determined by using a recently developed Kolsky torsion bar technique for tissue materials characterization. Quasi-static torsion experiments were also conducted on an MTS system to construct a full set of shear stress-strain curves over a wide range of shear strain rates (0.01-700 s(-1)). The experimental results show that the dynamic bulk modulus of brain is in the range of 1.68-2.33 GPa which is close to the low rate values reported in the literature, while the shear responses show significant rate sensitivity over the tested strain rate range. (c) 2012 Elsevier Ltd. All rights reserved. C1 [Nie, Xu] Univ N Texas, Dept Mech & Energy Engn, Denton, TX 76203 USA. [Chen, Weinong] Purdue Univ, Sch Aeronaut Astronaut & Mat Engn, W Lafayette, IN 47907 USA. [Sanborn, Brett; Weerasooriya, Tusit] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Chen, WN (reprint author), Purdue Univ, Sch Aeronaut Astronaut & Mat Engn, W Lafayette, IN 47907 USA. EM wchen@purdue.edu NR 31 TC 4 Z9 5 U1 0 U2 22 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD MAR PY 2013 VL 53 SI SI BP 56 EP 61 DI 10.1016/j.ijimpeng.2012.07.012 PG 6 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 077FD UT WOS:000314012400007 ER PT J AU Kotan, H Darling, KA Saber, M Scattergood, RO Koch, CC AF Kotan, Hasan Darling, Kris A. Saber, Mostafa Scattergood, Ronald O. Koch, Carl C. TI An in situ experimental study of grain growth in a nanocrystalline Fe91Ni8Zr1 alloy SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID THERMAL-STABILITY; SOLUTE SEGREGATION; STABILIZATION; STEEL AB Grain growth and microstructural evolution of thermally stabilized Fe91Ni8Zr1 were investigated by in situ and ex situ studies. Our investigations suggest that the microstructural evolution is fairly slow and the microstructure shows stabilization up to about 700 A degrees C. Above this temperature, a certain fraction of grains grow abnormally into the nanocrystalline matrix, resulting in a bimodal microstructure and causing the complete loss of thermal stability. The reason for abnormal grain growth and the loss of thermal stability is identified as the appearance of the fcc gamma-phase and consequent reduction in the total area of grain boundaries and the overall stored energy. C1 [Kotan, Hasan; Saber, Mostafa; Scattergood, Ronald O.; Koch, Carl C.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Darling, Kris A.] USA, Res Lab, Weap & Mat Res Directorate, RDRL WMM F, Aberdeen, MD 21005 USA. RP Kotan, H (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, 911 Partners Way,Room 3002, Raleigh, NC 27695 USA. EM hkotan@ncsu.edu OI Saber, Mostafa/0000-0002-6763-8637 FU NSF-DMR [1005677] FX The research reported in this paper was supported by NSF-DMR under grant number 1005677. NR 30 TC 12 Z9 12 U1 2 U2 38 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD MAR PY 2013 VL 48 IS 5 BP 2251 EP 2257 DI 10.1007/s10853-012-7002-1 PG 7 WC Materials Science, Multidisciplinary SC Materials Science GA 062GC UT WOS:000312906400045 ER PT J AU Guo, JS Zhou, J Chu, D Chen, RR AF Guo, Junsong Zhou, Jie Chu, Deryn Chen, Rongrong TI Tuning the Electrochemical Interface of Ag/C Electrodes in Alkaline Media with Metallophthalocyanine Molecules SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID MEMBRANE FUEL-CELLS; ANION-EXCHANGE MEMBRANE; OXYGEN REDUCTION REACTION; DENSITY-FUNCTIONAL THEORY; PERFORMANCE; CATALYSTS; PLATINUM; SURFACES; ELECTROCATALYSIS; NANOPARTICLES AB Transition metal phthalocyanine (MPc) molecules were shown to be able to modify the electrochemical interface of the Ag catalyst in the alkaline electrolyte. Depending on the binding strength of the MPc (M = Fe, Co, Ni, and Mn) molecules with the OH- species, the electrochemically active sites of the Ag electrode surfaces can be altered accordingly. A structural model for illustrating the electrochemical interface of the Ag/C catalysts modified by the MPc molecules in alkaline media is proposed, which can be used to elucidate the ORR kinetics observed on various MPc@Ag/C catalysts in AEMFCs. The optimal CoPc-OH and Ag-CoPc interactions resulted in the highest kinetic current density and power density (536 mW cm(-2) at 50 degrees C) observed with the AEMFCs using Co Pc modified Ag/C cathode catalysts in comparison with the Ag/C and other MPc (M = Fe, Ni, and Mn) modified Ag/C catalysts C1 [Guo, Junsong; Zhou, Jie; Chen, Rongrong] Indiana Univ Purdue Univ, Richard G Lugar Ctr Renewable Energy, Indianapolis, IN 46202 USA. [Chu, Deryn] USA, Res Lab, Adelphi, MD 20783 USA. RP Chen, RR (reprint author), Indiana Univ Purdue Univ, Richard G Lugar Ctr Renewable Energy, Indianapolis, IN 46202 USA. EM rochen@iupui.edu FU U.S. Army Research Lab [W911NF-10-2-0075] FX This work was supported by the U.S. Army Research Lab (W911NF-10-2-0075). NR 39 TC 8 Z9 9 U1 2 U2 56 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD FEB 28 PY 2013 VL 117 IS 8 BP 4006 EP 4017 DI 10.1021/jp310655y PG 12 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 134LN UT WOS:000318211800036 ER PT J AU Valiyaveettil, M Alamneh, Y Wang, Y Arun, P Oguntayo, S Wei, YL Long, JB Nambiar, MP AF Valiyaveettil, Manojkumar Alamneh, Yonas Wang, Ying Arun, Peethambaran Oguntayo, Samuel Wei, Yanling Long, Joseph B. Nambiar, Madhusoodana P. TI Contribution of systemic factors in the pathophysiology of repeated blast-induced neurotrauma SO NEUROSCIENCE LETTERS LA English DT Article DE Repeated blast exposure; Platelets; Leukocytes; Systemic factors; Traumatic brain injury ID TRAUMATIC BRAIN-INJURY; LYSOPHOSPHATIDIC ACID; SUICIDAL-BEHAVIOR; INTRACRANIAL-PRESSURE; NERVOUS-SYSTEM; SEROTONIN; MYELOPEROXIDASE; PLATELETS; MODEL; OVERPRESSURE AB Blast-induced traumatic brain injury is complex and involves multiple factors including systemic pathphysiological factors in addition to direct brain injuries. We hypothesize that systemic activation of platelets/leukocytes plays a major role in the development and exacerbation of brain injury after blast exposure. A mouse model of repeated blast exposure that results in significant neuropathology, neurobehavioral changes and regional specific alterations in various biomolecules in the brain was used for the proposed study. Activation of platelets was evaluated by flow cytometry and serotonin content was analyzed by ELISA. Expression of myeloperoxidase was analyzed by Western blotting. Histopathology of the brain was used to assess blast-induced cerebral vasoconstriction. The data showed an increase in the activation of platelets at 4 h after repeated blast exposures, indicating changes in platelet phenotype in blast neurotrauma. Platelet serotonin concentration showed a significant decrease at 4 h after blast with a concurrent increase in the plasma serotonin levels, confirming the early onset of platelet activation after repeated blast exposures. Blood, plasma and brain myeloperoxidase enzyme activity and expression was increased in repeated blast exposed mice at multiple time points. Histopathological analysis of the brains of blast exposed mice showed constriction of blood vessels compared to the respective controls, a phenomenon similar to the reported cerebral vasoconstriction in blast affected victims. These results suggest that repeated blast exposure leads to acute activation of platelets/leukocytes which can augment the pathological effects of brain injury. Platelet/leukocyte targeted therapies can be evaluated as potential acute treatment strategies to mitigate blast-induced neurotrauma. (C) 2013 Elsevier Ireland Ltd. All rights reserved. C1 [Valiyaveettil, Manojkumar; Alamneh, Yonas; Wang, Ying; Arun, Peethambaran; Oguntayo, Samuel; Wei, Yanling; Long, Joseph B.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Blast Induced Neurotrauma Branch, Silver Spring, MD 20910 USA. RP Valiyaveettil, M (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Blast Induced Neurotrauma Branch, Silver Spring, MD 20910 USA. EM m.valiyaveettil@us.army.mil; madhunambiar1@gmail.com NR 31 TC 8 Z9 8 U1 0 U2 6 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0304-3940 J9 NEUROSCI LETT JI Neurosci. Lett. PD FEB 28 PY 2013 VL 539 BP 1 EP 6 DI 10.1016/j.neulet.2013.01.028 PG 6 WC Neurosciences SC Neurosciences & Neurology GA 120FJ UT WOS:000317155900001 PM 23370286 ER PT J AU Underwood, T Roy, S Glaz, B AF Underwood, Thomas Roy, Subrata Glaz, Bryan TI Physics based lumped element circuit model for nanosecond pulsed dielectric barrier discharges SO JOURNAL OF APPLIED PHYSICS LA English DT Article AB This work presents a physics based circuit model for calculating the total energy dissipated into neutral species for nanosecond pulsed direct current (DC) dielectric barrier discharge (DBD) plasmas. Based on experimental observations, it is assumed that the nanosecond pulsed DBD's which have been proposed for aerodynamic flow control can be approximated by two independent regions of homogeneous electric field. An equivalent circuit model is developed for both homogeneous regions based on a combination of a resistor, capacitors, and a zener diode. Instead of fitting the resistance to an experimental data set, a formula is established for approximating the resistance by modeling plasmas as a conductor with DC voltage applied to it. Various assumptions are then applied to the governing Boltzmann equation to approximate electrical conductivity values for weakly ionized plasmas. The developed model is then validated with experimental data of the total power dissipated by plasmas. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4792665] C1 [Underwood, Thomas; Roy, Subrata] Univ Florida, Appl Phys Res Grp, Dept Mech & Aerosp Engn, Gainesville, FL 32611 USA. [Glaz, Bryan] USA, Vehicle Technol Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Underwood, T (reprint author), Univ Florida, Appl Phys Res Grp, Dept Mech & Aerosp Engn, Gainesville, FL 32611 USA. EM roy@ufl.edu RI Roy, Subrata/A-7493-2009 FU US Army Research Laboratory FX The first author's work was partially supported by an undergraduate internship at the US Army Research Laboratory. NR 12 TC 2 Z9 4 U1 1 U2 16 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD FEB 28 PY 2013 VL 113 IS 8 AR 083301 DI 10.1063/1.4792665 PG 11 WC Physics, Applied SC Physics GA 100AQ UT WOS:000315667500007 ER PT J AU Behler, KD Ciezak-Jenkins, JA Sausa, RC AF Behler, K. D. Ciezak-Jenkins, J. A. Sausa, R. C. TI High-Pressure Characterization of Nitrogen-Rich Bis-triaminoguanidinium Azotetrazolate (TAGzT) by In Situ Raman Spectroscopy SO JOURNAL OF PHYSICAL CHEMISTRY A LA English DT Article ID DIAMOND-ANVIL CELL; ENERGETIC MATERIALS; SALTS; CALIBRATION; PROPELLANT; MOLECULES; COMPOUND AB Compounds rich in nitrogen are attracting significant interest not only because of their high energy content but also because they are potentially more environmentally benign in comparison to conventional energetic materials. Given this interest, it is desirable to understand their molecular composition and structural variations with pressure to derive their stability and determine the conditions in which they transform physically or chemically. In this study, we examine the room-temperature isothermal compression behavior of bis-triaminoguanidinium azotetrazolate (TAGzT) by in situ Raman spectroscopy to pressures near 17 GPa. We assign the characteristic vibrational bands and report the effects of pressure on band intensity, line width, and frequency shift Two prominent peaks near 1370 and 1470 cm(-1) arise from the C-N and N=N symmetric stretches, respectively. Overall, the intensity of these bands and others diminishes with pressure, and their spectral linewidths increase monotonically upon compression. The vibrational frequency modes blue shift linearly upon compression, indicating a generalized stiffening of the bonds as the pressure increases. These results, together with micro Raman spectroscopic analyses of the recovered, decompressed samples, suggest that TAGzT does not undergo any phase transitions within this pressure range. We estimate and report the C-N and N=N intermolecular bond lengths under compression. C1 [Behler, K. D.] USA, Res Lab, RDRL WMM A, Aberdeen Proving Ground, MD 21005 USA. [Ciezak-Jenkins, J. A.; Sausa, R. C.] USA, Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. RP Sausa, RC (reprint author), USA, Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. EM rosario.c.sausa.civ@mail.mil FU ARL-BST Program FX We thank Dr. E. Byrd of the Army Research Laboratory (ARL) for the quantum mechanical bond energy calculations of TAGzT and Dr. J. Sloan and Ms. J. Leadore of ARL for helpful discussions regarding the micro Raman spectrometer. Also, we thank Dr. T. Jenkins of ARL for assistance with the Raman apparatus used in the high-pressure measurements and Dr. C. Michienzi of the Naval Surface Warfare Center for providing us with polycrystalline TAGzT. Dr. K. Behler is a Bowhead Science and Technology (BST) Senior Scientist at ARL and he gratefully acknowledges support from the ARL-BST Program. NR 38 TC 6 Z9 6 U1 2 U2 25 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1089-5639 J9 J PHYS CHEM A JI J. Phys. Chem. A PD FEB 28 PY 2013 VL 117 IS 8 BP 1737 EP 1743 DI 10.1021/jp311463g PG 7 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 100NL UT WOS:000315707800007 PM 23343336 ER PT J AU Wang, S Bromberg, L Schreuder-Gibson, H Hatton, TA AF Wang, Sa Bromberg, Lev Schreuder-Gibson, Heidi Hatton, T. Alan TI Organophophorous Ester Degradation by Chromium(III) Terephthalate Metal-Organic Framework (MIL-101) Chelated to N,N-Dimethylaminopyridine and Related Aminopyridines SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE metal-organic framework; aminopyridines; catalysis; organophosphorous ester hydrolysis; paraoxon ID LEWIS-BASE ACTIVATION; CATALYTIC-PROPERTIES; CARBON-DIOXIDE; REACTIVITY; CENTERS; ENCAPSULATION; COMPOSITES; HYDROLYSIS; STABILITY; EFFICIENT AB Porous materials based on chromium(III) terephthalate metal organic frameworks (MOF) MIL-101(Cr) and their complexes with dialkylaminopyridines (DAAP) were synthesized via a DAAP-MOF complexation, and tested for hydrolytic degradation of organophosphorous esters such as diethyl 4-nitrophenyl phosphate (paraoxon). Elemental analysis, TGA, XRD, FT-IR, TEM, SEM, and nitrogen adsorption measurements indicated that the DAAP units were incorporated into MIL-101 pores by complexation, keeping the parent framework intact. The DAAP-MOF enabled facile paraoxon hydrolysis in water/acetonitrile mixtures under ambient conditions (100% conversion after 24 h at pH 10). The MOF-DAAP complexes showed synergistic effects, being 7-fold and 47-fold more active than the parent MIL-101 or DAAP materials, respectively. The high hydrolysis reaction turnover was realized by simultaneous action of the Lewis acid Cr(III) center of the MOF as well as the electron-rich nucleophile, DAAP. This study demonstrates a simple and efficient method of generating catalytically active MOP materials for environmental detoxification as well as defensive applications. C1 [Wang, Sa; Bromberg, Lev; Hatton, T. Alan] MIT, Dept Chem Engn, Cambridge, MA 02139 USA. [Schreuder-Gibson, Heidi] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Hatton, TA (reprint author), MIT, Dept Chem Engn, Cambridge, MA 02139 USA. EM tahatton@mit.edu FU Defense Threat Reduction Agency [HDTR1-09-1-0012] FX The authors acknowledge the financial support from the Defense Threat Reduction Agency grant HDTR1-09-1-0012. The authors are grateful to Dr. Scott. A. Speakman for help with XRD results interpretation. NR 63 TC 24 Z9 24 U1 6 U2 120 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD FEB 27 PY 2013 VL 5 IS 4 BP 1269 EP 1278 DI 10.1021/am302359b PG 10 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA 099KE UT WOS:000315619100014 PM 23339453 ER PT J AU Lee, SY Walsh, GF Dal Negro, L AF Lee, Sylvanus Y. Walsh, Gary F. Dal Negro, Luca TI Microfluidics integration of aperiodic plasmonic arrays for spatial-spectral optical detection SO OPTICS EXPRESS LA English DT Article ID IMAGE CORRELATION SPECTROSCOPY; HIGH-DENSITY NANOSTRUCTURES; METAL NANOPARTICLES; CRITICAL MODES; SILK FILMS; FABRICATION; BIOSENSORS; LITHOGRAPHY; SCATTERING; SURFACES AB We demonstrate successful integration of aperiodic arrays of metal nanoparticles with microfluidics technology for optical sensing using the spectral-colorimetric responses of nanostructured arrays to refractive index variations. Different aperiodic arrays of gold (Au) nanoparticles with varying interparticle separations and Fourier spectral properties are fabricated using Electron Beam Lithography (EBL) and integrated with polydimethylsiloxane (PDMS) microfluidics structures by soft-lithographic micro-imprint techniques. The spectral shifts of scattering spectra and the distinctive modifications of structural color patterns induced by refractive index variations were simultaneously measured inside microfluidic flow cells by dark-field spectroscopy and image correlation analysis in the visible spectral range. The integration of engineered aperiodic arrays of Au nanoparticles with microfluidics devices provides a novel sensing platform with multiplexed spatial-spectral responses for opto-fluidics applications and lab-on-a-chip optical biosensing. (C) 2013 Optical Society of America C1 [Lee, Sylvanus Y.; Walsh, Gary F.; Dal Negro, Luca] Boston Univ, Dept Elect & Comp Engn, Boston, MA 02215 USA. [Lee, Sylvanus Y.; Walsh, Gary F.; Dal Negro, Luca] Boston Univ, Photon Ctr, Boston, MA 02215 USA. [Lee, Sylvanus Y.] Boston Univ, Dept Mech Engn, Boston, MA 02215 USA. [Walsh, Gary F.] USA, NSRDEC, Nanomat Sci Team, Natick, MA 01760 USA. [Dal Negro, Luca] Div Mat Sci & Engn, Boston, MA 02215 USA. RP Lee, SY (reprint author), Boston Univ, Dept Elect & Comp Engn, 8 St Marys St, Boston, MA 02215 USA. EM dalnegro@bu.edu FU AFOSR program "Deterministic Aperiodic Structures for On-chip Nanophotonic and Nanoplasmonic Device Applications" [FA9550-10-1-0019]; U.S. Army NSRDEC PAO [U12-491]; SMART Scholarship Program; APIC Corporation; PhotonIC Corporation FX The work was supported by the AFOSR program "Deterministic Aperiodic Structures for On-chip Nanophotonic and Nanoplasmonic Device Applications" under Award FA9550-10-1-0019, the U.S. Army NSRDEC PAO # U12-491, the SMART Scholarship Program, APIC Corporation and by PhotonIC Corporation. NR 60 TC 7 Z9 7 U1 2 U2 51 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD FEB 25 PY 2013 VL 21 IS 4 BP 4945 EP 4957 DI 10.1364/OE.21.004945 PG 13 WC Optics SC Optics GA 104KU UT WOS:000315992600100 PM 23482027 ER PT J AU Ngo-Duc, TT Gacusan, J Kobayashi, NP Sanghadasa, M Meyyappan, M Oye, MM AF Tam-Triet Ngo-Duc Gacusan, Jovi Kobayashi, Nobuhiko P. Sanghadasa, Mohan Meyyappan, M. Oye, Michael M. TI Controlled growth of vertical ZnO nanowires on copper substrate SO APPLIED PHYSICS LETTERS LA English DT Article ID MOLECULAR-BEAM EPITAXY; NANOSTRUCTURES; NANORODS; ARRAYS; MOCVD AB We present an approach for diameter control of vertically aligned ZnO nanowires (NWs) grown directly on copper substrates. Vapor-solid growth was done at 550 degrees C with solid Zn precursor under Ar/O-2 flow, and the resulting nanowires with in situ-controllable diameters ranged between 50 to 500 nm. The nanowires were observed to elongate in tip growth and diameters were directly controlled by varying the oxygen concentration. Direct growth of vertical wires on metal substrates is expected to be useful to construct piezoelectric devices and applications involving sensors and detectors. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4793758] C1 [Tam-Triet Ngo-Duc; Gacusan, Jovi; Meyyappan, M.; Oye, Michael M.] NASA, Ames Res Ctr, Ctr Nanotechnol, Moffett Field, CA 94035 USA. [Tam-Triet Ngo-Duc; Gacusan, Jovi; Oye, Michael M.] NASA, Ames Res Ctr, ELORET Corp, Moffett Field, CA 94035 USA. [Tam-Triet Ngo-Duc; Gacusan, Jovi; Kobayashi, Nobuhiko P.; Oye, Michael M.] NASA, Ames Res Ctr, UCSC NASA ARC Adv Studies Labs, Moffett Field, CA 94035 USA. [Kobayashi, Nobuhiko P.; Oye, Michael M.] Univ Calif Santa Cruz, Dept Elect Engn, Santa Cruz, CA 95064 USA. [Sanghadasa, Mohan] USA, Weap Sci Directorate, Aviat & Missile RDEC, RDECOM, Redstone Arsenal, AL 35898 USA. RP Oye, MM (reprint author), NASA, Ames Res Ctr, Ctr Nanotechnol, Moffett Field, CA 94035 USA. EM Michael.M.Oye@nasa.gov RI Kobayashi, Nobuhiko/E-3834-2012 FU DARPA [W31P4Q-11-c-0230]; NASA [NNX09AQ44A] FX This work was partially supported by DARPA contract W31P4Q-11-c-0230 to ELORET Corp. A NASA grant NNX09AQ44A to University of California Santa Cruz is acknowledged for instruments in the UCSC MACS Facility within the UCSC/NASA-ARC ASL. NR 23 TC 9 Z9 9 U1 1 U2 64 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD FEB 25 PY 2013 VL 102 IS 8 AR 083105 DI 10.1063/1.4793758 PG 4 WC Physics, Applied SC Physics GA 099CN UT WOS:000315597000066 ER PT J AU Kotan, H Darling, KA Saber, M Koch, CC Scattergood, RO AF Kotan, Hasan Darling, Kris A. Saber, Mostafa Koch, Carl C. Scattergood, Ronald O. TI Effect of zirconium on grain growth and mechanical properties of a ball-milled nanocrystalline FeNi alloy SO JOURNAL OF ALLOYS AND COMPOUNDS LA English DT Article DE Nanocrystalline materials; Thermal stabilization; Grain growth; Shear-punch test; Mechanical properties ID VACANCY FORMATION ENERGIES; THERMAL-STABILITY; SOLUTE SEGREGATION; NI ALLOYS; NANOSTRUCTURED MATERIALS; PRECIPITATE PARTICLES; DISLOCATION LINE; BOUNDARY; HARDNESS; METALS AB Grain growth of ball-milled pure Fe, Fe92Ni8, and Fe91Ni8Zr1 alloys has been studied using X-ray diffractometry (XRD), focused ion beam (FIB) microscopy and transmission electron microscopy (TEM). Mechanical properties with respect to compositional changes and annealing temperatures have been investigated using microhardness and shear punch tests. We found the rate of grain growth of the Fe91Ni8Zr1 alloy to be much less than that of pure Fe and the Fe92Ni8 alloy at elevated temperatures. The microstructure of the ternary Fe91Ni8Zr1 alloy remains nanoscale up to 700 degrees C where only a few grains grow abnormally whereas annealing of pure iron and the Fe92Ni8 alloy leads to extensive grain growth. The grain growth of the ternary alloy at high annealing temperatures is coupled with precipitation of Fe2Zr. A fine dispersion of precipitated second phase is found to promote the microstructural stability at high annealing temperatures and to increase the hardness and ultimate shear strength of ternary Fe91Ni8Zr1 alloy drastically when the grain size is above nanoscale. (C) 2012 Elsevier B.V. All rights reserved. C1 [Kotan, Hasan; Saber, Mostafa; Koch, Carl C.; Scattergood, Ronald O.] NC State Univ, Dept Mat Sci & Engn, Raleigh, NC 27606 USA. [Darling, Kris A.] USA, Res Lab, Weap & Mat Res Directorate, RDRL WMM F, Aberdeen Proving Ground, MD 21005 USA. RP Kotan, H (reprint author), NC State Univ, Dept Mat Sci & Engn, 911 Partners Way,Room 3078, Raleigh, NC 27606 USA. EM hkotan@ncsu.edu FU NSF-DMR [1005677] FX The research reported in this paper was supported by NSF-DMR under grant number 1005677. NR 59 TC 11 Z9 11 U1 6 U2 74 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0925-8388 EI 1873-4669 J9 J ALLOY COMPD JI J. Alloy. Compd. PD FEB 25 PY 2013 VL 551 BP 621 EP 629 DI 10.1016/j.jallcom.2012.10.179 PG 9 WC Chemistry, Physical; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Chemistry; Materials Science; Metallurgy & Metallurgical Engineering GA 072EI UT WOS:000313651600104 ER PT J AU Moreno, M Bickersmith, S Harlow, W Hildebrandt, J McKeon, SN Silva-do-Nascimento, TF Loaiza, JR Ruiz, F Lourenco-de-Oliveira, R Sallum, MAM Bergo, ES Fritz, GN Wilkerson, RC Linton, YM Juri, MJD Rangel, Y Povoa, MM Gutierrez-Builes, LA Correa, MM Conn, JE AF Moreno, Marta Bickersmith, Sara Harlow, Wesley Hildebrandt, Jessica McKeon, Sascha N. Silva-do-Nascimento, Teresa Fernandes Loaiza, Jose R. Ruiz, Freddy Lourenco-de-Oliveira, Ricardo Sallum, Maria A. M. Bergo, Eduardo S. Fritz, Gary N. Wilkerson, Richard C. Linton, Yvonne M. Dantur Juri, Maria J. Rangel, Yadira Povoa, Marinete M. Gutierrez-Builes, Lina A. Correa, Margarita M. Conn, Jan E. TI Phylogeography of the neotropical Anopheles triannulatus complex (Diptera: Culicidae) supports deep structure and complex patterns SO PARASITES & VECTORS LA English DT Article DE Anopheles triannulatus s.s.; Anopheles halophylus; Anopheles triannulatus C; phylogeography; COI gene; White gene; ITS2 ID MITOCHONDRIAL-DNA; MALARIA VECTOR; PHYLOGENETIC-RELATIONSHIPS; POPULATION-STRUCTURE; GENETIC-STRUCTURE; BRAZILIAN AMAZON; MOLECULAR PHYLOGENETICS; SPECIES DIPTERA; CENTRAL-AMERICA; SOUTH-AMERICA AB Background: The molecular phylogenetic relationships and population structure of the species of the Anopheles triannulatus complex: Anopheles triannulatus s.s., Anopheles halophylus and the putative species Anopheles triannulatus C were investigated. Methods: The mitochondrial COI gene, the nuclear white gene and rDNA ITS2 of samples that include the known geographic distribution of these taxa were analyzed. Phylogenetic analyses were performed using Bayesian inference, Maximum parsimony and Maximum likelihood approaches. Results: Each data set analyzed separately yielded a different topology but none provided evidence for the separation of An. halophylus and An. triannulatus C, consistent with the hypothesis that the two are undergoing incipient speciation. The phylogenetic analyses of the white gene found three main clades, whereas the statistical parsimony network detected only a single metapopulation of Anopheles triannulatus s. l. Seven COI lineages were detected by phylogenetic and network analysis. In contrast, the network, but not the phylogenetic analyses, strongly supported three ITS2 groups. Combined data analyses provided the best resolution of the trees, with two major clades, Amazonian (clade I) and trans-Andean + Amazon Delta (clade II). Clade I consists of multiple subclades: An. halophylus + An. triannulatus C; trans-Andean Venezuela; central Amazonia + central Bolivia; Atlantic coastal lowland; and Amazon delta. Clade II includes three subclades: Panama; cis-Andean Colombia; and cis-Venezuela. The Amazon delta specimens are in both clades, likely indicating local sympatry. Spatial and molecular variance analyses detected nine groups, corroborating some of subclades obtained in the combined data analysis. Conclusion: Combination of the three molecular markers provided the best resolution for differentiation within An. triannulatus s. s. and An. halophylus and C. The latest two species seem to be very closely related and the analyses performed were not conclusive regarding species differentiation. Further studies including new molecular markers would be desirable to solve this species status question. Besides, results of the study indicate a trans-Andean origin for An. triannulatus s. l. The potential implications for malaria epidemiology remain to be investigated. C1 [Moreno, Marta; Bickersmith, Sara; Harlow, Wesley; Hildebrandt, Jessica; McKeon, Sascha N.; Conn, Jan E.] New York State Dept Hlth, Wadsworth Ctr, Griffin Lab, Albany, NY USA. [McKeon, Sascha N.; Conn, Jan E.] SUNY Albany, Sch Publ Hlth, Dept Biomed Sci, Albany, NY USA. [Silva-do-Nascimento, Teresa Fernandes; Lourenco-de-Oliveira, Ricardo] Inst Oswaldo Cruz Fiocruz, Dept Entomol, Rio De Janeiro, Brazil. [Loaiza, Jose R.] Inst Invest Cient & Serv Alta Tecnol, Clayton, Panama. [Ruiz, Freddy; Wilkerson, Richard C.; Linton, Yvonne M.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD USA. [Sallum, Maria A. M.] Univ Sao Paulo, Fac Saude Publ, Dept Epidemiol, BR-01255 Sao Paulo, Brazil. [Bergo, Eduardo S.] SUCEN, Superintendencia Controle Endemias, Sao Paulo, Brazil. [Fritz, Gary N.] Eastern Illinois Univ, Dept Biol Sci, Charleston, IL 61920 USA. [Dantur Juri, Maria J.] Univ Nacl Tucuman, Inst Super Entomol Dr Abraham Willink, Fac Ciencias Nat & Inst Miguel Lillo, San Miguel De Tucuman, Argentina. [Rangel, Yadira] Cent Univ Venezuela, Lab Biol Vectores, Inst Zool & Ecol Trop, Caracas, Venezuela. [Povoa, Marinete M.] Inst Evandro Chagas, Seccao Parasitol, Belem, Para, Brazil. [Gutierrez-Builes, Lina A.; Correa, Margarita M.] Univ Antioquia, Escuela Microbiol, Grp Microbiol Mol, Medellin, Colombia. RP Moreno, M (reprint author), Univ Calif San Diego, Sch Med, Div Infect Dis, George Palade Labs, 9500 Gilman Dr,MC 0741, La Jolla, CA 92093 USA. EM mmorenoleirana@ucsd.edu RI Sallum, Maria/B-8537-2012; OI Conn, Jan/0000-0002-5301-7020; BERGO, EDUARDO/0000-0003-4928-0368; Gutierrez Builes, Lina Andrea/0000-0002-5336-6984 FU NIH [AI ROI 54139-02]; PAPES IV Fiocruz-CNPq; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, FAPESP [2011/20397-7]; CNPq [301666/2011-3] FX This project has been financially supported by NIH grant AI ROI 54139-02 to JE Conn, PAPES IV Fiocruz-CNPq to RLO, and from the Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, FAPESP (Grant 2011/20397-7 to MAMS), CNPq (BPP no. 301666/2011-3 to MAMS). NR 90 TC 7 Z9 7 U1 0 U2 18 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1756-3305 J9 PARASITE VECTOR JI Parasites Vectors PD FEB 22 PY 2013 VL 6 AR 47 DI 10.1186/1756-3305-6-47 PG 17 WC Parasitology SC Parasitology GA 114TN UT WOS:000316765600001 PM 23433428 ER PT J AU Moncunill, G Mayor, A Jimenez, A Nhabomba, A Puyol, L Manaca, MN Barrios, D Cistero, P Guinovart, C Aguilar, R Bardaji, A Pinazo, MJ Angov, E Dutta, S Chitnis, CE Munoz, J Gascon, J Dobano, C AF Moncunill, Gemma Mayor, Alfredo Jimenez, Alfons Nhabomba, Augusto Puyol, Laura Manaca, Maria N. Barrios, Diana Cistero, Pau Guinovart, Caterina Aguilar, Ruth Bardaji, Azucena Pinazo, Maria-Jesus Angov, Evelina Dutta, Sheetij Chitnis, Chetan E. Munoz, Jose Gascon, Joaquim Dobano, Carlota TI Cytokine and Antibody Responses to Plasmodium falciparum in Naive Individuals during a First Malaria Episode: Effect of Age and Malaria Exposure SO PLOS ONE LA English DT Article ID ERYTHROCYTE-MEMBRANE PROTEIN-1; VARIANT SURFACE-ANTIGENS; INFECTED ERYTHROCYTES; MOZAMBICAN CHILDREN; ACQUIRED-IMMUNITY; CLINICAL MALARIA; PREGNANT-WOMEN; BLOOD-STAGE; PROTECTION; INTERLEUKIN-12 AB Age- and exposure-dependent immune responses during a malaria episode may be key to understanding the role of these factors in the acquisition of immunity to malaria. Plasma/serum samples collected from naive Mozambican children (n = 48), European adults (naive travelers, n = 22; expatriates with few prior malaria exposures, n = 15) and Mozambican adults with long-life malaria exposure (n = 99) during and after a malaria episode were analyzed for IgG against merozoite proteins by Luminex and against infected erythrocytes by flow cytometry. Cytokines and chemokines were analyzed in plasmas/sera by suspension array technology. No differences were detected between children and adults with a primary infection, with the exception of higher IgG levels against 3D7 MSP-1(42) (P = 0.030) and a P. falciparum isolate (P = 0.002), as well as higher IL-12 (P = 0.020) in children compared to other groups. Compared to malaria-exposed adults, children, travelers and expatriates had higher concentrations of IFN-gamma (P <= 0.0090), IL-2 (P <= 0.0379) and IL-8 (P <= 0.0233). Children also had higher IL-12 (P = 0.0001), IL-4 (P = 0.003), IL-1 beta (P = 0.024) and TNF (P = 0.006) levels compared to malaria-exposed adults. Although IL-12 was elevated in children, overall the data do not support a role of age in immune responses to a first malaria episode. A T(H)1/pro-inflammatory response was the hallmark of non-immune subjects. C1 [Moncunill, Gemma; Mayor, Alfredo; Jimenez, Alfons; Puyol, Laura; Barrios, Diana; Cistero, Pau; Guinovart, Caterina; Aguilar, Ruth; Bardaji, Azucena; Pinazo, Maria-Jesus; Munoz, Jose; Gascon, Joaquim; Dobano, Carlota] Univ Barcelona, Barcelona Ctr Int Hlth Res, Hosp Clin, CRESIB, Barcelona, Spain. [Mayor, Alfredo; Nhabomba, Augusto; Manaca, Maria N.; Guinovart, Caterina; Aguilar, Ruth; Dobano, Carlota] Ctr Invest Saude Manhica, Maputo, Mozambique. [Angov, Evelina; Dutta, Sheetij] Walter Reed Army Inst Res, Silver Spring, MD USA. [Chitnis, Chetan E.] Int Ctr Genet Engn & Biotechnol, New Delhi, India. RP Moncunill, G (reprint author), Univ Barcelona, Barcelona Ctr Int Hlth Res, Hosp Clin, CRESIB, Barcelona, Spain. EM gemma.moncunil@cresib.cat RI Gascon, Joaquim/M-3598-2015; Dobano, Carlota/N-4119-2014; OI Gascon, Joaquim/0000-0002-5045-1585; Dobano, Carlota/0000-0002-6751-4060; Moncunill, Gemma/0000-0001-5105-9836 FU Ministerio de Ciencia e Innovacion [SAF2008-00743, SAF2005-25642-E, RYC-2008-02631]; Instituto de Salud Carlos III [PI050275, A107190024, PS0901113, CD10/00156, CP-4/00220, CM04/00028]; EU FP6 [LSHP-CT-2005-18902]; Fundacion Ramon Areces FX The study received financial support from the Ministerio de Ciencia e Innovacion (SAF2008-00743, SAF2005-25642-E, salary support RYC-2008-02631 to CD); the Instituto de Salud Carlos III (PI050275, A107190024, PS0901113, salary support CD10/00156 to GM, CP-4/00220 to AM, and CM04/00028 to CG), the EU FP6 (LSHP-CT-2005-18902), and the Fundacion Ramon Areces. The Centro de Investigacao em Saude de Manhica receives core support from the Spanish Agency for International Cooperation and Development (AECID). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 57 TC 8 Z9 9 U1 2 U2 17 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 21 PY 2013 VL 8 IS 2 AR e55756 DI 10.1371/journal.pone.0055756 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 093IT UT WOS:000315186000008 PM 23437061 ER PT J AU Kraczek, B Chung, PW AF Kraczek, B. Chung, P. W. TI Investigation of direct and indirect phonon-mediated bond excitation in alpha-RDX SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID ENERGY-TRANSFER RATES; WAVE INDUCED DECOMPOSITION; HOT-SPOT FORMATION; MOLECULAR-CRYSTALS; IMPACT SENSITIVITIES; FORCE-FIELD; EXPLOSIVES; DYNAMICS; CHEMISTRY; SOLIDS AB We evaluate whether lattice or internal phonons dominate the thermal excitation of the N-N bonds in alpha-cyclotrimethylene trinitramine (alpha-RDX) by computing the fractional contributions of phonon modes to the excitation of all atomic interactions. We derive a method to compute these contributions, which we call mode energy fractions, from the phonon eigenvectors and a splitting of the dynamical matrix. This enables identification of phonon modes that most strongly excite the N-N bonds that play a key role in molecular decomposition of alpha-RDX. Correlating these fractions with the mode populations and contributions to the specific heat and thermal conductivity, we analyze how thermal energy is distributed by phonons following a passing shock. Contrary to the common explanation that thermal energy is transferred to the N-N bonds indirectly, by internal phonons, we find that lattice phonons dominate this thermal energy transfer, implying that energy flow follows a direct route. We also comment on implications of these results for non-shock decomposition of alpha-RDX. [http://dx.doi.org/10.1063/1.4790637] C1 [Kraczek, B.; Chung, P. W.] USA, Computat & Informat Sci Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Kraczek, B (reprint author), USA, Computat & Informat Sci Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM brent.kraczek@us.army.mil; peter.w.chung@us.army.mil FU Department of the Army Program [0601102A H44 06]; Department of Defense/Army High Performance Computing Modernization Program for Multi-scale Reactive Modeling of Insensitive Munitions Software Applications Institute; Oak Ridge Affiliated Universities (ORAU) in Maryland .U.S. [W911QX-04-C-0129] FX This work was supported in part by the Department of the Army Program Element 0601102A H44 06 for Defense Research Sciences, the Department of Defense/Army High Performance Computing Modernization Program for Multi-scale Reactive Modeling of Insensitive Munitions Software Applications Institute, and Oak Ridge Affiliated Universities (ORAU) in Maryland under the Contract No. W911QX-04-C-0129 at the U.S. Army Research Laboratory. The authors wish to thank Jennifer Ciezak-Jenkins for helpful discussions. NR 49 TC 7 Z9 7 U1 1 U2 14 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-9606 EI 1089-7690 J9 J CHEM PHYS JI J. Chem. Phys. PD FEB 21 PY 2013 VL 138 IS 7 AR 074505 DI 10.1063/1.4790637 PG 10 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 094LE UT WOS:000315263500037 PM 23445022 ER PT J AU Wu, DR Lance, BJ Parsons, TD AF Wu, Dongrui Lance, Brent J. Parsons, Thomas D. TI Collaborative Filtering for Brain-Computer Interaction Using Transfer Learning and Active Class Selection SO PLOS ONE LA English DT Article ID PERFORMANCE ASSESSMENT TEST; VIRTUAL-REALITY; INTERFACES AB Brain-computer interaction (BCI) and physiological computing are terms that refer to using processed neural or physiological signals to influence human interaction with computers, environment, and each other. A major challenge in developing these systems arises from the large individual differences typically seen in the neural/physiological responses. As a result, many researchers use individually-trained recognition algorithms to process this data. In order to minimize time, cost, and barriers to use, there is a need to minimize the amount of individual training data required, or equivalently, to increase the recognition accuracy without increasing the number of user-specific training samples. One promising method for achieving this is collaborative filtering, which combines training data from the individual subject with additional training data from other, similar subjects. This paper describes a successful application of a collaborative filtering approach intended for a BCI system. This approach is based on transfer learning (TL), active class selection (ACS), and a mean squared difference user-similarity heuristic. The resulting BCI system uses neural and physiological signals for automatic task difficulty recognition. TL improves the learning performance by combining a small number of user-specific training samples with a large number of auxiliary training samples from other similar subjects. ACS optimally selects the classes to generate user-specific training samples. Experimental results on 18 subjects, using both k nearest neighbors and support vector machine classifiers, demonstrate that the proposed approach can significantly reduce the number of user-specific training data samples. This collaborative filtering approach will also be generalizable to handling individual differences in many other applications that involve human neural or physiological data, such as affective computing. C1 [Wu, Dongrui] GE Global Res, Machine Learning Lab, Niskayuna, NY USA. [Lance, Brent J.] USA, Res Lab, Aberdeen, MD USA. [Parsons, Thomas D.] Univ N Texas, Dept Psychol, Denton, TX 76203 USA. RP Wu, DR (reprint author), GE Global Res, Machine Learning Lab, Niskayuna, NY USA. EM drwu09@gmail.com NR 65 TC 9 Z9 9 U1 0 U2 19 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 21 PY 2013 VL 8 IS 2 AR e56624 DI 10.1371/journal.pone.0056624 PG 18 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 093IT UT WOS:000315186000035 PM 23437188 ER PT J AU Ramakrishnan, S Rajaraman, S Laxminarayan, S Wesensten, NJ Kamimori, GH Balkin, TJ Reifman, J AF Ramakrishnan, Sridhar Rajaraman, Srinivasan Laxminarayan, Srinivas Wesensten, Nancy J. Kamimori, Gary H. Balkin, Thomas J. Reifman, Jaques TI A biomathematical model of the restoring effects of caffeine on cognitive performance during sleep deprivation SO JOURNAL OF THEORETICAL BIOLOGY LA English DT Article DE Caffeine model; Sleep loss; PVT; Individualized modeling; Pharmacokinetic-pharmacodynamic model ID NORMAL HEALTHY-VOLUNTEERS; PROLONGED WAKEFULNESS; DEPRIVED INDIVIDUALS; 2-PROCESS MODEL; CHEWING GUM; FATIGUE; PLASMA; PHARMACOKINETICS; VIGILANCE; COUNTERMEASURES AB Rationale: While caffeine is widely used as a countermeasure to sleep loss, mathematical models are lacking. Objective: Develop a biomathematical model for the performance-restoring effects of caffeine in sleep-deprived subjects. Methods: We hypothesized that caffeine has a multiplicative effect on performance during sleep loss. Accordingly, we first used a phenomenological two-process model of sleep regulation to estimate performance in the absence of caffeine, and then multiplied a caffeine-effect factor, which relates the pharmacokinetic-pharmacodynamic effects through the Hill equation, to estimate the performance-restoring effects of caffeine. Results: We validated the model on psychomotor vigilance test data from two studies involving 12 subjects each: (1) single caffeine dose of 600 mg after 64.5 h of wakefulness and (2) repeated doses of 200 mg after 20, 22, and 24 h of wakefulness. Individualized caffeine models produced overall errors that were 19% and 42% lower than their population-average counterparts for the two studies. Had we not accounted for the effects of caffeine, the individualized model errors would have been 117% and 201% larger, respectively. Conclusions: The presented model captured the performance-enhancing effects of caffeine for most subjects in the single- and repeated-dose studies, suggesting that the proposed multiplicative factor is a feasible solution. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Ramakrishnan, Sridhar; Rajaraman, Srinivasan; Laxminarayan, Srinivas; Reifman, Jaques] USA, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, DoD Biotechnol High Performance Comp Software App, Frederick, MD 21702 USA. [Wesensten, Nancy J.; Kamimori, Gary H.; Balkin, Thomas J.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD 20910 USA. RP Reifman, J (reprint author), USA, Med Res & Mat Command, ATTN MCMR TT,Telemed & Adv Technol Res Ctr, DoD Biotechnol High Performance Comp Software App, 504 Scott St, Ft Detrick, MD 21702 USA. EM jaques.reifman@us.army.mil FU Military Operational Medicine Research Area Directorate of the U.S. Army Medical Research and Materiel Command, Ft. Detrick, MD; U.S. Department of Defense Medical Research and Development Program [DMRDP_13200] FX This work was sponsored by the Military Operational Medicine Research Area Directorate of the U.S. Army Medical Research and Materiel Command, Ft. Detrick, MD, and by the U.S. Department of Defense Medical Research and Development Program (Grant No. DMRDP_13200). NR 46 TC 4 Z9 4 U1 0 U2 31 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0022-5193 J9 J THEOR BIOL JI J. Theor. Biol. PD FEB 21 PY 2013 VL 319 BP 23 EP 33 DI 10.1016/j.jtbi.2012.11.015 PG 11 WC Biology; Mathematical & Computational Biology SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational Biology GA 084QA UT WOS:000314553000003 PM 23182694 ER PT J AU Zou, XT Wu, N Tian, Y Zhang, Y Fitek, J Maffeo, M Niezrecki, C Chen, J Wang, XW AF Zou, Xiaotian Wu, Nan Tian, Ye Zhang, Yang Fitek, John Maffeo, Michael Niezrecki, Christopher Chen, Julie Wang, Xingwei TI Ultrafast Fabry-Perot fiber-optic pressure sensors for multimedia blast event measurements SO APPLIED OPTICS LA English DT Article ID SHOCK-WAVE; INJURIES AB A shock wave (SW) is characterized as a large pressure fluctuation that typically lasts only a few milliseconds. On the battlefield, SWs pose a serious threat to soldiers who are exposed to explosions, which may lead to blast-induced traumatic brain injuries. SWs can also be used beneficially and have been applied to a variety of medical treatments due to their unique interaction with tissues and cells. Consequently, it is important to have sensors that can quantify SW dynamics in order to better understand the physical interaction between body tissue and the incident acoustic wave. In this paper, the ultrafast fiber-optic sensor based on the Fabry-Perot interferometric principle was designed and four such sensors were fabricated to quantify a blast event within different media, simultaneously. The compact design of the fiber-optic sensor allows for a high degree of spatial resolution when capturing the wavefront of the traveling SW. Several blast event experiments were conducted within different media (e. g., air, rubber membrane, and water) to evaluate the sensor's performance. This research revealed valuable knowledge for further study of SW behavior and SW-related applications. (C) 2013 Optical Society of America C1 [Zou, Xiaotian; Wang, Xingwei] Univ Massachusetts Lowell, Dept Biomed Engn & Biotechnol, Lowell, MA 01854 USA. [Wu, Nan; Tian, Ye; Zhang, Yang; Wang, Xingwei] Univ Massachusetts Lowell, Dept Elect & Comp Engn, Lowell, MA 01854 USA. [Fitek, John; Maffeo, Michael] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. [Niezrecki, Christopher; Chen, Julie] Univ Massachusetts Lowell, Dept Mech Engn, Lowell, MA 01854 USA. RP Wang, XW (reprint author), Univ Massachusetts Lowell, Dept Biomed Engn & Biotechnol, 1 Univ Ave, Lowell, MA 01854 USA. EM xingwei_wang@uml.edu RI Tian, Ye/A-1090-2014; Zou, Xiaotian/J-8657-2013 OI Tian, Ye/0000-0002-0785-1145; FU Army Research Laboratory [W911NF-07-2-0081] FX The authors are grateful for the collaboration with Natick Soldier Research, Development and Engineering Center for sharing the shock tube and the reference pressure sensors. The authors also appreciate the Army Research Laboratory for sponsoring this work (Nanomanufacturing of Multifunctional Sensors Award Number W911NF-07-2-0081). NR 20 TC 5 Z9 5 U1 2 U2 30 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD FEB 20 PY 2013 VL 52 IS 6 BP 1248 EP 1254 DI 10.1364/AO.52.001248 PG 7 WC Optics SC Optics GA 094TM UT WOS:000315286700018 PM 23434996 ER PT J AU Barrett, A Ndou, T Hughey, CA Straut, C Howell, A Dai, ZF Kaletunc, G AF Barrett, Ann Ndou, Tshinanne Hughey, Christine A. Straut, Christine Howell, Amy Dai, Zifei Kaletunc, Gonul TI Inhibition of alpha-Amylase and Glucoamylase by Tannins Extracted from Cocoa, Pomegranates, Cranberries, and Grapes SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY LA English DT Article DE condensed tannins; proanthocyanidins; alpha-amylase inhibition; glucoamylase inhibition; pomegranate; cocoa; cranberry; grape; LC/MS; NMR; DSC ID FIMBRIATED ESCHERICHIA-COLI; MASS-SPECTROMETRY; A-TYPE; POLYMERIC PROCYANIDINS; PLASMA-GLUCOSE; PROANTHOCYANIDINS; POLYPHENOLS; ADHERENCE; JUICE; BLUEBERRY AB Proanthocyanidins and ellagitannins, referred to as "tannins", exist in many plant sources. These compounds interact with proteins due to their numerous hydroxyl groups, which are suitable for hydrophobic associations. It was hypothesized that tannins could bind to the digestive enzymes a-amylase and glucoamylase, thereby inhibiting starch hydrolysis. Slowed starch digestion can theoretically increase satiety by modulating glucose "spiking" and depletion that occurs after carbohydrate-rich meals. Tannins were isolated from extracts of pomegranate, cranberry, grape, and cocoa and these isolates tested for effectiveness to inhibit the activity of a-amylase and glucoamylase in vitro. The compositions of the isolates were confirmed by NMR and LC/MS analysis, and tannin protein interactions were investigated using relevant enzyme assays and differential scanning calorimetry (DSC). The results demonstrated inhibition of each enzyme by each tannin, but with variation in magnitude. In general, larger and more complex tannins, such as those in pomegranate and cranberry, more effectively inhibited the enzymes than did less polyrnerized cocoa tannins. Interaction of the tannins with the enzymes was confirmed through calorimetric measurements of changes in enzyme thermal stability. C1 [Barrett, Ann; Ndou, Tshinanne] USA, PORT Combat Feeding Directorate, NSRDEC, Natick, MA 01760 USA. [Hughey, Christine A.] James Madison Univ, Dept Chem & Biochem, Harrisonburg, VA 22807 USA. [Hughey, Christine A.] USA, Batelle Warfighter Sci Technol & Res Directorate, NSRDEC, Natick, MA 01760 USA. [Howell, Amy] Rutgers State Univ, Marucci Ctr Blueberry Cranberry Res, Chatsworth, NJ 08019 USA. [Dai, Zifei; Kaletunc, Gonul] Ohio State Univ, Dept Food Agr & Biol Engn, Columbus, OH 43210 USA. RP Barrett, A (reprint author), USA, PORT Combat Feeding Directorate, NSRDEC, Natick, MA 01760 USA. EM ann.h.barrett.civ@mail.mil FU National Science Foundation [NSF MRI CHE-0922935, CHE-1046630] FX This material is partially based upon work supported by the National Science Foundation under Grants NSF MRI CHE-0922935 and CHE-1046630. NR 44 TC 26 Z9 27 U1 9 U2 95 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0021-8561 J9 J AGR FOOD CHEM JI J. Agric. Food Chem. PD FEB 20 PY 2013 VL 61 IS 7 BP 1477 EP 1486 DI 10.1021/jf304876g PG 10 WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science & Technology SC Agriculture; Chemistry; Food Science & Technology GA 095HV UT WOS:000315326200009 PM 23289516 ER PT J AU Manocchi, AK Baker, DR Pendley, SS Nguyen, K Hurley, MM Bruce, BD Sumner, JJ Lundgren, CA AF Manocchi, Amy K. Baker, David R. Pendley, Scott S. Khoa Nguyen Hurley, Margaret M. Bruce, Barry D. Sumner, James J. Lundgren, Cynthia A. TI Photocurrent Generation from Surface Assembled Photosystem I on Alkanethiol Modified Electrodes SO LANGMUIR LA English DT Article ID PHOTOSYNTHETIC REACTION CENTERS; HARVESTING CORE COMPLEXES; REACTION-CENTER PROTEIN; ANGSTROM RESOLUTION; MONOLAYERS; GOLD; ELECTROCHEMISTRY; FABRICATION; BACTERIA; GLUCOSE AB Photosystem I (PSI) is a key component of oxygenic photosynthetic electron transport because of its light-induced electron transfer to the soluble electron acceptor ferredoxin. This work demonstrates the incorporation of surface assembled cyanobacterial trimeric PSI complexes into a biohybrid system for light-driven current generation. Specifically, this work demonstrates the improved assembly of PSI via electrophoretic deposition, with controllable surface assembled PSI density, on different self-assembled alkanethiol monolayers. Using artificial electron donors and acceptors (Os(bpy)(2)Cl-2 and methyl viologen) we demonstrate photocurrent generation from a single PSI layer, which remains photoactive for at least three hours of intermittent illumination. Photoelectrochemical comparison of the biohybrid systems assembled from different alkanethiols (hexanethiol, aminohexanethiol, mercaptohexanol, and mercaptohexanoic acid) reveals that the PSI generated photocurrent is enhanced by almost 5 times on negatively charged SAM surfaces as compared to positively charged surfaces. These results are discussed in light of how PSI is oriented upon electrodeposition on a SAM. C1 [Manocchi, Amy K.; Baker, David R.; Sumner, James J.; Lundgren, Cynthia A.] USA, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA. [Pendley, Scott S.; Hurley, Margaret M.] USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Khoa Nguyen; Bruce, Barry D.] Univ Tennessee, Biochem Cellular & Mol Biol Dept, Knoxville, TN 37996 USA. [Bruce, Barry D.] Univ Tennessee, Chem & Biomol Engn Dept, Knoxville, TN 37996 USA. RP Lundgren, CA (reprint author), USA, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA. EM cynthia.a.lundgren2.civ@mail.mil FU U.S. Department of the Army; U.S. Army Materiel Command; U.S. Army Research Laboratory; NSF [EPS-1004083] FX Financial support from the U.S. Department of the Army and U.S. Army Materiel Command are gratefully acknowledged. Research was supported, in part, by a contractual appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities (A.(M., D.R.B., S.S.P.). B.D.B. was partially supported by a NSF grant, EPS-1004083. NR 36 TC 25 Z9 25 U1 2 U2 89 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD FEB 19 PY 2013 VL 29 IS 7 BP 2412 EP 2419 DI 10.1021/la304477u PG 8 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 121RA UT WOS:000317260700037 PM 23379304 ER PT J AU Boscolo, S Pelin, M De Bortoli, M Fontanive, G Barreras, A Berti, F Sosa, S Chaloin, O Bianco, A Yasumoto, T Prato, M Poli, M Tubaro, A AF Boscolo, S. Pelin, M. De Bortoli, M. Fontanive, G. Barreras, A. Berti, F. Sosa, S. Chaloin, O. Bianco, A. Yasumoto, T. Prato, M. Poli, M. Tubaro, A. TI Sandwich ELISA Assay for the Quantitation of Palytoxin and Its Analogs in Natural Samples SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID OF-THE-ART; CROSS-LINKING; ENZYME-IMMUNOASSAY; PUTATIVE PALYTOXIN; OSTREOPSIS-OVATA; ANTIBODIES; OVATOXINS; STATE; IDENTIFICATION; SPECTROMETRY AB Palytoxins are potent marine biotoxins that have recently become endemic to the Mediterranean Sea, and are becoming more frequently associated with seafood. Due to their high toxicity, suitable methods to quantify palytoxins are needed. Thus, we developed an indirect sandwich ELISA for palytoxin and 42-hydroxy-palytoxin. An intra-laboratory study demonstrated sensitivity (limit of detection, LOD = 1.1 ng/mL; limit of quantitation, LOQ = 2.2 ng/mL), accuracy (bias of 2.1%), repeatability (RSDr = 6% and 9% for intra- and interassay variability, respectively) and specificity: other common marine toxins (okadaic acid, domoic acid, saxitoxin, brevetoxin-3, and yessotoxin) do not cross-react in this assay. It performed well in three different matrices: observed LOQs were 11.0, 9.6, and 2.4 ng/mL for mussel extracts, algal net samples and seawater, respectively, with good accuracy and precision. The LOQ in seafood is 11 mu g palytoxin/kg mussel meat, lower than that of the most common detection technique, LC-MS/MS. C1 [Boscolo, S.; Tubaro, A.] Univ Trieste, Dept Life Sci, I-34127 Trieste, Italy. [Pelin, M.; De Bortoli, M.; Barreras, A.; Sosa, S.] Univ Trieste, Dept Life Sci, I-34127 Trieste, Italy. [Fontanive, G.; Berti, F.] Univ Trieste, Dept Chem & Pharmaceut Sci, I-34127 Trieste, Italy. [Chaloin, O.; Bianco, A.] CNRS, Inst Biol Mol & Cellulaire, Lab Immunol & Chim Therapeut, F-67000 Strasbourg, France. [Yasumoto, T.] Tama Lab, Japan Food Res Labs, Tama, Tokyo 2060025, Japan. [Prato, M.] Univ Trieste, Dept Chem & Pharmaceut Sci, I-34127 Trieste, Italy. [Poli, M.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21701 USA. RP Tubaro, A (reprint author), Univ Trieste, Dept Life Sci, Via L Giorgieri 10, I-34127 Trieste, Italy. EM tubaro@units.it RI Prato, Maurizio/G-7067-2012 OI Prato, Maurizio/0000-0002-8869-8612 FU Regione Autonoma Friuli-Venezia Giulia, Direzione Risorse Rurali, Agroalimentari e Forestali FX This work was supported by Regione Autonoma Friuli-Venezia Giulia, Direzione Risorse Rurali, Agroalimentari e Forestali. M.P. is grateful to the Italian Ministry of Education (cofin Prot. 20085M27SS). A.B and O.C. are grateful to the Centre National de la Recherche Scientifique (France). WE are grateful to Prof. G. Honsell (University of Udine, Italy) for providing and characterization of algal samples and to Dr. E. D'Orlando (University of Trieste, Italy) for her assistance. NR 42 TC 12 Z9 12 U1 1 U2 59 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD FEB 19 PY 2013 VL 47 IS 4 BP 2034 EP 2042 DI 10.1021/es304222t PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 095IA UT WOS:000315326700032 PM 23339823 ER PT J AU Hairston, WD Letowski, TR McDowell, K AF Hairston, W. David Letowski, Tomasz R. McDowell, Kaleb TI Task-Related Suppression of the Brainstem Frequency following Response SO PLOS ONE LA English DT Article ID AUDITORY SELECTIVE ATTENTION; EVOKED-POTENTIALS; INFERIOR COLLICULUS; MUSICAL EXPERIENCE; VISUAL-CORTEX; SPEECH; MODULATION; PITCH; STIMULI; DEACTIVATION AB Recent evidence has shown top-down modulation of the brainstem frequency following response (FFR), generally in the form of signal enhancement from concurrent stimuli or from switching between attention-demanding task stimuli. However, it is also possible that the opposite may be true - the addition of a task, instead of a resting, passive state may suppress the FFR. Here we examined the influence of a subsequent task, and the relevance of the task modality, on signal clarity within the FFR. Participants performed visual and auditory discrimination tasks in the presence of an irrelevant background sound, as well as a baseline consisting of the same background stimuli in the absence of a task. FFR pitch strength and amplitude of the primary frequency response were assessed within non-task stimulus periods in order to examine influences due solely to general cognitive state, independent of stimulus-driven effects. Results show decreased signal clarity with the addition of a task, especially within the auditory modality. We additionally found consistent relationships between the extent of this suppressive effect and perceptual measures such as response time and proclivity towards one sensory modality. Together these results suggest that the current focus of attention can have a global, top-down effect on the quality of encoding early in the auditory pathway. C1 [Hairston, W. David; Letowski, Tomasz R.; McDowell, Kaleb] USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA. RP Hairston, WD (reprint author), USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA. EM William.d.hairston4.civ@mail.mil OI Hairston, W. David/0000-0003-4432-8430 NR 60 TC 15 Z9 15 U1 2 U2 11 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 18 PY 2013 VL 8 IS 2 AR e55215 DI 10.1371/journal.pone.0055215 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 092YP UT WOS:000315159200008 PM 23441150 ER PT J AU Shoemaker, CJ Schornberg, KL Delos, SE Scully, C Pajouhesh, H Olinger, GG Johansen, LM White, JM AF Shoemaker, Charles J. Schornberg, Kathryn L. Delos, Sue E. Scully, Corinne Pajouhesh, Hassan Olinger, Gene G. Johansen, Lisa M. White, Judith M. TI Multiple Cationic Amphiphiles Induce a Niemann-Pick C Phenotype and Inhibit Ebola Virus Entry and Infection SO PLOS ONE LA English DT Article ID ATOMIC PHYSICOCHEMICAL PARAMETERS; SMALL-MOLECULE INHIBITORS; ACID SPHINGOMYELINASE; QUANTITATIVE STRUCTURE; CATHEPSIN-L; LOG-P; GLYCOPROTEIN; PROTEIN; CELLS; CHOLESTEROL AB Ebola virus (EBOV) is an enveloped RNA virus that causes hemorrhagic fever in humans and non-human primates. Infection requires internalization from the cell surface and trafficking to a late endocytic compartment, where viral fusion occurs, providing a conduit for the viral genome to enter the cytoplasm and initiate replication. In a concurrent study, we identified clomiphene as a potent inhibitor of EBOV entry. Here, we screened eleven inhibitors that target the same biosynthetic pathway as clomiphene. From this screen we identified six compounds, including U18666A, that block EBOV infection (IC50 1.6 to 8.0 mu M) at a late stage of entry. Intriguingly, all six are cationic amphiphiles that share additional chemical features. U18666A induces phenotypes, including cholesterol accumulation in endosomes, associated with defects in Niemann-Pick C1 protein (NPC1), a late endosomal and lysosomal protein required for EBOV entry. We tested and found that all six EBOV entry inhibitors from our screen induced cholesterol accumulation. We further showed that higher concentrations of cationic amphiphiles are required to inhibit EBOV entry into cells that overexpress NPC1 than parental cells, supporting the contention that they inhibit EBOV entry in an NPC1-dependent manner. A previously reported inhibitor, compound 3.47, inhibits EBOV entry by blocking binding of the EBOV glycoprotein to NPC1. None of the cationic amphiphiles tested had this effect. Hence, multiple cationic amphiphiles (including several FDA approved agents) inhibit EBOV entry in an NPC1-dependent fashion, but by a mechanism distinct from that of compound 3.47. Our findings suggest that there are minimally two ways of perturbing NPC1-dependent pathways that can block EBOV entry, increasing the attractiveness of NPC1 as an anti-filoviral therapeutic target. C1 [Shoemaker, Charles J.; Schornberg, Kathryn L.; Delos, Sue E.; White, Judith M.] Univ Virginia, Dept Cell Biol, Charlottesville, VA 22903 USA. [Scully, Corinne; Olinger, Gene G.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Pajouhesh, Hassan; Johansen, Lisa M.] Zalicus Inc, Cambridge, MA USA. [White, Judith M.] Univ Virginia, Dept Microbiol, Charlottesville, VA 22908 USA. RP White, JM (reprint author), Univ Virginia, Dept Cell Biol, Charlottesville, VA 22903 USA. EM jw7g@virginia.edu OI Olinger, Gene/0000-0001-7338-0292 FU DTRA [4.10007_08_RD_B, W81XWH-08-0051, W81XWH-12-P-0007]; National Institutes of Health [U54 AI057168] FX Work was supported by: DTRA project 4.10007_08_RD_B (G.G.O) and subcontracts W81XWH-08-0051 (L.M.J) and W81XWH-12-P-0007(JMW) as well as a grant from the National Institutes of Health: U54 AI057168 (J.M.W). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 63 TC 41 Z9 42 U1 2 U2 31 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 18 PY 2013 VL 8 IS 2 AR e56265 DI 10.1371/journal.pone.0056265 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 092YP UT WOS:000315159200028 PM 23441171 ER PT J AU Okusaga, O Cahill, JP Docherty, A Menyuk, CR Zhou, WM AF Okusaga, Olukayode Cahill, James P. Docherty, Andrew Menyuk, Curtis R. Zhou, Weimin TI Spontaneous inelastic Rayleigh scattering in optical fibers SO OPTICS LETTERS LA English DT Article AB Rayleigh scattering (RS) adds noise to signals that are transmitted over optical fibers and other optical waveguides. This noise can be the dominant noise source in a range between 10 Hz and 100 kHz from the carrier and can seriously degrade the performance of optical systems that require low close-in noise. Using heterodyne techniques, we demonstrate that the backscattered close-in noise spectrum in optical fibers is symmetric about the carrier and grows linearly with both input power and fiber length. These results indicate that the RS is spontaneous and is due to finite-lifetime thermal fluctuations in the glass. (c) 2013 Optical Society of America C1 [Okusaga, Olukayode; Cahill, James P.; Zhou, Weimin] USA, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. [Cahill, James P.; Docherty, Andrew; Menyuk, Curtis R.] Univ Maryland Baltimore Cty, Comp Sci & Elect Engn Dept, Baltimore, MD 21250 USA. RP Okusaga, O (reprint author), USA, Res Lab, Sensors & Elect Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM olukayode.k.okusaga.civ@mail.mil FU DARPA; ARL; MPCA FX The authors thank Dr. James Hanssen and Dr. Christopher Ekstrom of the U.S. Naval Observatory for their invaluable assistance in developing the heterodyne optical interferometer. Work at UMBC was supported by DARPA, ARL, and MPCA. NR 10 TC 8 Z9 8 U1 1 U2 12 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD FEB 15 PY 2013 VL 38 IS 4 BP 549 EP 551 PG 3 WC Optics SC Optics GA 099EB UT WOS:000315601700055 PM 23455132 ER PT J AU Boylan, GL Goethals, PL Cho, BR AF Boylan, Gregory L. Goethals, Paul L. Cho, Byung Rae TI Robust parameter design in resource-constrained environments: An investigation of trade-offs between costs and precision within variable processes SO APPLIED MATHEMATICAL MODELLING LA English DT Article DE Robust parameter design; Optimal design; Design of experiments; Monte Carlo simulation; Nonlinear optimization ID RESPONSE-SURFACE OPTIMIZATION; MODEL; OPTIMALITY; TAGUCHI; SYSTEMS AB Engineers and scientists often identify robust parameter design as one of the most important process and quality improvement methods. Focused on statistical modeling and numerical optimization strategies, most researchers typically assume a process with reasonably small variability. Realistically, however, industrial processes often exhibit larger variability, particularly in mass production lines. In such cases, many of the modeling assumptions behind the robust parameter design models available in the literature do not hold. Accordingly, the results and recommendations provided to decision makers could generate suboptimal modifications to processes and products. As manufacturers seek improved methods for ensuring quality in resource-constrained environments, experimenters should examine trade-offs to achieve the levels of precision that best support their decision making. In contrast to previous research, this paper proposes a trade-off analysis between the cost of replication and the desired precision of generated solutions. We consider several techniques in the early stages of experimental design, using Monte Carlo simulation as a tool, for revealing potential options to the decision maker. This is perhaps the first study to show the avenue which may lead to more effective robust parameter design models with the optimal combination of cost constraints and desired precision of solutions. (C) 2012 Elsevier Inc. All rights reserved. C1 [Boylan, Gregory L.; Cho, Byung Rae] Clemson Univ, Dept Ind Engn, Adv Qual Engn Lab, Clemson, SC 29634 USA. [Goethals, Paul L.] US Mil Acad, Dept Math Sci, West Point, NY 10997 USA. RP Boylan, GL (reprint author), Clemson Univ, Dept Ind Engn, Adv Qual Engn Lab, Room 150,Freeman Hall, Clemson, SC 29634 USA. EM gboylan@clemson.edu; paul.goethals@usma.edu; bcho@clemson.edu NR 50 TC 2 Z9 2 U1 0 U2 9 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0307-904X J9 APPL MATH MODEL JI Appl. Math. Model. PD FEB 15 PY 2013 VL 37 IS 4 BP 2394 EP 2416 DI 10.1016/j.apm.2012.05.017 PG 23 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications; Mechanics SC Engineering; Mathematics; Mechanics GA 073SW UT WOS:000313763800064 ER PT J AU Luong, DD Strbik, OM Hammond, VH Gupta, N Cho, K AF Luong, Dung D. Strbik, Oliver M., III Hammond, Vincent H. Gupta, Nikhil Cho, Kyu TI Development of high performance lightweight aluminum alloy/SiC hollow sphere syntactic foams and compressive characterization at quasi-static and high strain rates SO JOURNAL OF ALLOYS AND COMPOUNDS LA English DT Article DE Metal-matrix composites (MMCs); Mechanical properties; Porosity; Metallography ID ASH CENOSPHERE COMPOSITES; DEFORMATION-BEHAVIOR; ENERGY-ABSORPTION; MICROSTRUCTURE; MICROSPHERES; PROPERTY; IRON AB Aluminum alloy A356 filled with silicon carbide hollow spheres (SiCHS) is investigated for quasi-static (10(-3) s(-1)) and high strain rate (up to 1520 s(-1)) compressive properties. Such closed cell composite foams, called syntactic foams, are of interest in weight sensitive structural applications. The present work is focused on understanding the compressive failure mechanism and relating them with the material microstructure. The compressive and plateau strengths of syntactic foams with SiCHS are found to be 163 and 110 MPa, respectively. The measured properties are considerably higher than the existing fly ash cenosphere filled aluminum matrix syntactic foams. Compressive failure mechanisms are studied for A356/SiCHS syntactic foams and direct evidence of hollow sphere crushing at the end of the elastic regions is obtained. The predictions of compressive strength obtained from an existing model are validated with the experimental results. Extensive analysis of data on open and closed cell foams containing gas porosity and syntactic foams is presented. A clear advantage in terms of low density and high yield strength is observed in A356/SiCHS syntactic foams compared to other foams. Yield strength of aluminum foams may be different at high strain rate compression compared to quasi-static values but most of the foams do not show strong evidence of strain rate sensitivity within the high strain rate regime. (C) 2012 Elsevier B.V. All rights reserved. C1 [Luong, Dung D.; Gupta, Nikhil] NYU, Polytech Inst, Dept Mech & Aerosp Engn, Composite Mat & Mech Lab, Brooklyn, NY 11201 USA. [Strbik, Oliver M., III] Deep Springs Technol LLC, Toledo, OH 43615 USA. [Hammond, Vincent H.; Cho, Kyu] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Gupta, N (reprint author), NYU, Polytech Inst, Dept Mech & Aerosp Engn, Composite Mat & Mech Lab, Brooklyn, NY 11201 USA. EM ngupta@poly.edu FU U.S. Army Research Laboratory [W911NF-10-2-0084]; DST FX Portions of the research reported in this paper were performed in connection with U.S. Army Research Laboratory contract W911NF-10-2-0084 with DST and Cooperative Working Agreement W911NF-11-2-0096 with NYU-Poly. The views and conclusions contained in this presentation are those of the authors and should not be interpreted as presenting the official policies or position, either expressed or implied, of the ARL or the U.S. Government unless so designated by other authorized documents. Citation of manufacturers' or trade names does not constitute an official endorsement or approval of the use notwithstanding any copyright notation hereon. NR 55 TC 41 Z9 41 U1 6 U2 95 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0925-8388 J9 J ALLOY COMPD JI J. Alloy. Compd. PD FEB 15 PY 2013 VL 550 BP 412 EP 422 DI 10.1016/j.jallcom.2012.10.171 PG 11 WC Chemistry, Physical; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Chemistry; Materials Science; Metallurgy & Metallurgical Engineering GA 051TG UT WOS:000312149700068 ER PT J AU Chuang, I Sedegah, M Cicatelli, S Spring, M Polhemus, M Tamminga, C Patterson, N Guerrero, M Bennett, JW McGrath, S Ganeshan, H Belmonte, M Farooq, F Abot, E Banania, JG Huang, J Newcomer, R Rein, L Litilit, D Richie, NO Wood, C Murphy, J Sauerwein, R Hermsen, CC McCoy, AJ Kamau, E Cummings, J Komisar, J Sutamihardja, A Shi, M Epstein, JE Maiolatesi, S Tosh, D Limbach, K Angov, E Bergmann-Leitner, E Bruder, JT Doolan, DL King, CR Carucci, D Dutta, S Soisson, L Diggs, C Hollingdale, MR Ockenhouse, CF Richie, TL AF Chuang, Ilin Sedegah, Martha Cicatelli, Susan Spring, Michele Polhemus, Mark Tamminga, Cindy Patterson, Noelle Guerrero, Melanie Bennett, Jason W. McGrath, Shannon Ganeshan, Harini Belmonte, Maria Farooq, Fouzia Abot, Esteban Banania, Jo Glenna Huang, Jun Newcomer, Rhonda Rein, Lisa Litilit, Dianne Richie, Nancy O. Wood, Chloe Murphy, Jittawadee Sauerwein, Robert Hermsen, Cornelus C. McCoy, Andrea J. Kamau, Edwin Cummings, James Komisar, Jack Sutamihardja, Awalludin Shi, Meng Epstein, Judith E. Maiolatesi, Santina Tosh, Donna Limbach, Keith Angov, Evelina Bergmann-Leitner, Elke Bruder, Joseph T. Doolan, Denise L. King, C. Richter Carucci, Daniel Dutta, Sheetij Soisson, Lorraine Diggs, Carter Hollingdale, Michael R. Ockenhouse, Christian F. Richie, Thomas L. TI DNA Prime/Adenovirus Boost Malaria Vaccine Encoding P-falciparum CSP and AMA1 Induces Sterile Protection Associated with Cell-Mediated Immunity SO PLOS ONE LA English DT Article ID APICAL MEMBRANE ANTIGEN-1; CYTOTOXIC T-LYMPHOCYTES; PHASE 2A TRIAL; NAIVE ADULTS; CIRCUMSPOROZOITE PROTEIN; NEUTRALIZING ANTIBODIES; SPOROZOITE INOCULATION; VIRUS ANKARA; DOUBLE-BLIND; IMMUNIZATION AB Background: Gene-based vaccination using prime/boost regimens protects animals and humans against malaria, inducing cell-mediated responses that in animal models target liver stage malaria parasites. We tested a DNA prime/adenovirus boost malaria vaccine in a Phase 1 clinical trial with controlled human malaria infection. Methodology/Principal Findings: The vaccine regimen was three monthly doses of two DNA plasmids (DNA) followed four months later by a single boost with two non-replicating human serotype 5 adenovirus vectors (Ad). The constructs encoded genes expressing P. falciparum circumsporozoite protein (CSP) and apical membrane antigen-1 (AMA1). The regimen was safe and well-tolerated, with mostly mild adverse events that occurred at the site of injection. Only one AE (diarrhea), possibly related to immunization, was severe (Grade 3), preventing daily activities. Four weeks after the Ad boost, 15 study subjects were challenged with P. falciparum sporozoites by mosquito bite, and four (27%) were sterilely protected. Antibody responses by ELISA rose after Ad boost but were low (CSP geometric mean titer 210, range 44-817; AMA1 geometric mean micrograms/milliliter 11.9, range 1.5-102) and were not associated with protection. Ex vivo IFN-gamma ELISpot responses after Ad boost were modest (CSP geometric mean spot forming cells/million peripheral blood mononuclear cells 86, range 13-408; AMA1 348, range 88-1270) and were highest in three protected subjects. ELISpot responses to AMA1 were significantly associated with protection (p = 0.019). Flow cytometry identified predominant IFN-gamma mono-secreting CD8+ T cell responses in three protected subjects. No subjects with high pre-existing anti-Ad5 neutralizing antibodies were protected but the association was not statistically significant. Significance: The DNA/Ad regimen provided the highest sterile immunity achieved against malaria following immunization with a gene-based subunit vaccine (27%). Protection was associated with cell-mediated immunity to AMA1, with CSP probably contributing. Substituting a low seroprevalence vector for Ad5 and supplementing CSP/AMA1 with additional antigens may improve protection. C1 [Chuang, Ilin; Sedegah, Martha; Tamminga, Cindy; Patterson, Noelle; McGrath, Shannon; Ganeshan, Harini; Belmonte, Maria; Farooq, Fouzia; Abot, Esteban; Banania, Jo Glenna; Huang, Jun; Litilit, Dianne; McCoy, Andrea J.; Sutamihardja, Awalludin; Epstein, Judith E.; Maiolatesi, Santina; Limbach, Keith; Doolan, Denise L.; Carucci, Daniel; Hollingdale, Michael R.; Richie, Thomas L.] USN, US Mil Malaria Vaccine Program, Med Res Ctr, Silver Spring, MD USA. [Cicatelli, Susan; Spring, Michele; Polhemus, Mark; Guerrero, Melanie; Bennett, Jason W.; Newcomer, Rhonda; Rein, Lisa; Richie, Nancy O.; Wood, Chloe; Murphy, Jittawadee; Kamau, Edwin; Cummings, James; Komisar, Jack; Shi, Meng; Tosh, Donna; Angov, Evelina; Bergmann-Leitner, Elke; Dutta, Sheetij; Ockenhouse, Christian F.] Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD USA. [Sauerwein, Robert; Hermsen, Cornelus C.] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands. [Bruder, Joseph T.; King, C. Richter] GenVec Inc, Gaithersburg, MD USA. [Soisson, Lorraine; Diggs, Carter] USAID, Washington, DC USA. RP Richie, TL (reprint author), USN, US Mil Malaria Vaccine Program, Med Res Ctr, Silver Spring, MD USA. EM thomas.richie@med.navy.mil RI Sauerwein, Robert/C-8519-2013; Bennett, Jason/B-3547-2011; Bergmann-Leitner, Elke/B-3548-2011; Doolan, Denise/F-1969-2015; Hermsen, C.C./L-4368-2015; OI Bergmann-Leitner, Elke/0000-0002-8571-8956; Richie, Thomas/0000-0002-2946-5456 FU USAID "Development of Adenovirus-Vectored Malaria Vaccines" [GHA-P-00-03-00006-01, 936-3118]; Congressionally Directed Medical Research Program "Development of Recombinant Adenoviral-based Vaccines against Malaria" [W81XWH-05-2-0041]; Military Infectious Research Program "Phase 1/2a clinical trials assessing the safety, tolerability, immunogenicity protective efficacy of Ad5-CA, a two-antigen, adenovirus-vectored Plasmodium falciparum malaria vaccine, in healthy, malaria-nave adults" [62787A 870 F 1432] FX This work was supported by USAID "Development of Adenovirus-Vectored Malaria Vaccines" Grant #: GHA-P-00-03-00006-01, Project Number 936-3118; and the Congressionally Directed Medical Research Program "Development of Recombinant Adenoviral-based Vaccines against Malaria" Grant #: W81XWH-05-2-0041.. Website: https://cdmrp.org. Military Infectious Research Program "Phase 1/2a clinical trials assessing the safety, tolerability, immunogenicity & protective efficacy of Ad5-CA, a two-antigen, adenovirus-vectored Plasmodium falciparum malaria vaccine, in healthy, malaria-nave adults", work unit number 62787A 870 F 1432. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 52 TC 57 Z9 60 U1 0 U2 18 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 14 PY 2013 VL 8 IS 2 AR e55571 DI 10.1371/journal.pone.0055571 PG 15 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 099EJ UT WOS:000315602700019 PM 23457473 ER PT J AU Sirk, TW Moore, S Brown, EF AF Sirk, Timothy W. Moore, Stan Brown, Eugene F. TI Characteristics of thermal conductivity in classical water models SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID NONEQUILIBRIUM MOLECULAR-DYNAMICS; LIQUID WATER; COULOMBIC SYSTEMS; METHANE HYDRATE; EWALD METHOD; SIMULATION; MESH; POTENTIALS; EQUATIONS; SUMMATION AB The thermal conductivities of common water models are compared using equilibrium (EMD) and non-equilibrium molecular dynamics (NEMD) simulation. A complete accounting for electrostatic contributions to the heat flux was found to resolve the previously reported differing results of NEMD and EMD Green-Kubo measurements for the extended simple point-charge (SPC/E) model. Accordingly, we demonstrate the influence of long-range electrostatics on the thermal conductivity with a simple coulomb cutoff, Ewald summation, and by an extended particle-particle particle-mesh method. For each water model, the thermal conductivity is computed and decomposed in terms of frequency-dependent thermodynamic and topological contributions. The rigid, three-site SPC, SPC/E, and transferable intermolecular potential (TIP3P-Ew) water models are shown to have similar thermal conductivity values at standard conditions, whereas models that include bond stretching and angle bending have higher thermal conductivities. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4789961] C1 [Sirk, Timothy W.] USA, Macromol Sci & Technol Branch, Res Lab, Aberdeen, MD 21005 USA. [Moore, Stan] Sandia Natl Labs, Scalable Algorithms Dept, Albuquerque, NM 87185 USA. [Brown, Eugene F.] Virginia Polytech Inst & State Univ, Dept Mech Engn, Blacksburg, VA 24061 USA. RP Sirk, TW (reprint author), USA, Macromol Sci & Technol Branch, Res Lab, Aberdeen, MD 21005 USA. EM tim.sirk@us.army.mil RI Brown, Eugene/F-2017-2014 FU AREVA, Inc., North America of Lynchburg, Virginia; Center for Advanced Engineering and Research, Forest, Virginia FX The authors thank Steve Plimpton (Sandia National Laboratories) for contributions to the LAMMPS implementation and Jan-Michael Carrillo (University of Connecticut), for example Madelung calculations. Partial support is acknowledged from an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the USARL. Partial support is acknowledged from AREVA, Inc., North America of Lynchburg, Virginia and the Center for Advanced Engineering and Research, Forest, Virginia. NR 53 TC 31 Z9 31 U1 7 U2 73 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD FEB 14 PY 2013 VL 138 IS 6 AR 064505 DI 10.1063/1.4789961 PG 11 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 091MS UT WOS:000315054400027 PM 23425477 ER PT J AU Taylor, DE Runge, K Cory, MG Burns, DS Vasey, JL Hearn, JD Griffith, K Henley, MV AF Taylor, DeCarlos E. Runge, Keith Cory, Marshall G. Burns, Douglas S. Vasey, Joseph L. Hearn, John D. Griffith, Kara Henley, Michael V. TI Surface Binding of Organophosphates on Silica: Comparing Experiment and Theory SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID DIMETHYL METHYLPHOSPHONATE; ADSORBED ORGANOPHOSPHONATES; MOLECULAR-DYNAMICS; AMORPHOUS SILICA; AB-INITIO; ADSORPTION; SENSORS; SIO2; ENERGIES; VAPOR AB A consistent embedding hierarchy is applied to the calculation of binding enthalpies for organophosphate molecules to a silica surface and compared to experiment. The interaction of four probe molecules, dimethyl methylphosphonate (DMMP), diisopropyl methylphosphonate (DIMP), diisopropyl fluorophosphate (DFP), and sarin, with the silica surface is examined. Quantum chemical methods are employed to compute binding enthalpies and vibrational spectra for all interactions between probe molecules and silanol sites on the silica surface. Comparison with experimentally measured infrared shifts indicates that the theoretically modeled adsorption sites are similar to those found in experiment. The calculated binding enthalpies agree well with experiment for sarin, Delta H-ads,H-443K = -22.0 kcal/mol (calculated) vs -18.8 +/- 5,5 kcal/mol (measured, 433 K < T-expt < 453 K), and DIMP, Delta H-ads,H-463K = -26.9 kcal/mol (calculated) vs -29.3 +/- 0.9 kcal/mol (measured, 453 K < T-expt < 473 K). Agreement with experiment is less good for DMMP, Delta H-ads,H-463K = -19.7 kcal/mol (calculated) vs -26.1 +/- 1.5 kcal/mol (measured, 453 K < T-expt < 473 K), and DFP, Delta H-ads,H-423K = -20.4 kcal/mol (calculated) vs -27.5 +/- 3.1, kcal/mol (measured, 413 K < T-expt < 433 K). C1 [Taylor, DeCarlos E.] USA, Res Lab, Weap & Mat Res Directorate, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. [Runge, Keith] BWD Associates LLC, Gainesville, FL 32653 USA. [Cory, Marshall G.; Burns, Douglas S.; Vasey, Joseph L.] ENSCO Inc, Melbourne, FL 32940 USA. [Hearn, John D.; Henley, Michael V.] US AFRL RXQL, Tyndall AFB, FL 32403 USA. [Griffith, Kara] UTC Inc, Tyndall AFB, FL 32403 USA. RP Runge, K (reprint author), BWD Associates LLC, 2901 Northwest 54th Ave, Gainesville, FL 32653 USA. EM krunge@bellsouth.net FU Defense Threat Reduction Agency (DTRA) [HDTRA1-10-C-0015] FX This work was supported by the Defense Threat Reduction Agency (DTRA) (Contract #: HDTRA1-10-C-0015). While this research has been funded by the agency, the results and content of this publication do not necessarily reflect the views and opinions of the funding agency. NR 27 TC 7 Z9 7 U1 0 U2 52 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD FEB 14 PY 2013 VL 117 IS 6 BP 2699 EP 2708 DI 10.1021/jp306713d PG 10 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 093HH UT WOS:000315181800038 ER PT J AU Hu, HT Nau, M Ehrenberg, P Chenine, AL Macedo, C Zhou, Y Daye, ZJ Wei, Z Vahey, M Michael, NL Kim, JH Marovich, M Ratto-Kim, S AF Hu, Haitao Nau, Martin Ehrenberg, Phil Chenine, Agnes-Laurence Macedo, Camila Zhou, Yu Daye, Z. John Wei, Zhi Vahey, Maryanne Michael, Nelson L. Kim, Jerome H. Marovich, Mary Ratto-Kim, Silvia TI Distinct gene-expression profiles associated with the susceptibility of pathogen-specific CD4 T cells to HIV-1 infection SO BLOOD LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; PERIPHERAL-BLOOD; MYCOBACTERIUM-TUBERCULOSIS; CYTOMEGALOVIRUS RETINITIS; REPLICATION; RISK; INDIVIDUALS; ACTIVATION; DEPLETION; PROTEIN AB In HIV infection, CD4 responses to opportunistic pathogens such as Candida albicans are lost early, but CMV-specific CD4 response persists. Little is currently known about HIV infection of CD4 T cells of different pathogen/antigen specificities. CFSE-labeled PBMCs were stimulated with CMV, tetanus toxoid (TT), and C albicans antigens and subsequently exposed to HIV. HIV infection was monitored by intracellular p24 in CFSElow population. We found that although TT- and C albicans-specific CD4 T cells were permissive, CMV-specific CD4 T cells were highly resistant to both R5 and X4 HIV. Quantification of HIV DNA in CFSElow cells showed a reduction of strong-stop and full-length DNA in CMV-specific cells compared with TT- and C albicans-specific cells. beta-Chemokine neutralization enhanced HIV infection in TT- and C albicans-specific cells, whereas HIV infection in CMV-specific cells remained low despite increased entry by beta-chemokine neutralization, suggesting postentry HIV restriction by CMV-specific cells. Microarray analysis (Gene Expression Omnibus accession number: GSE42853) revealed distinct transcriptional profiles that involved selective up-regulation of comprehensive innate antiviral genes in CMV-specific cells, whereas TT- and C albicans-specific cells mainly up-regulated Th17 inflammatory response. Our data suggest a mechanism for the persistence of CMV-specific CD4 response and earlier loss of mucosal Th17-associated TT- and C albicans-specific CD4 response in AIDS. (Blood. 2013; 121(7): 1136-1144) C1 [Hu, Haitao; Nau, Martin; Ehrenberg, Phil; Chenine, Agnes-Laurence; Macedo, Camila; Vahey, Maryanne; Michael, Nelson L.; Kim, Jerome H.; Marovich, Mary; Ratto-Kim, Silvia] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Zhou, Yu] Temple Univ, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19122 USA. [Daye, Z. John] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Div Epidemiol & Biostat, Tucson, AZ USA. [Wei, Zhi] New Jersey Inst Technol, Dept Comp Sci, Newark, NJ 07102 USA. RP Hu, HT (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM hhu@hivresearch.org FU Henry M. Jackson Foundation [W81XWH-07-2-0067]; US Department of Defense FX The work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation and the US Department of Defense. NR 49 TC 17 Z9 17 U1 0 U2 9 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD FEB 14 PY 2013 VL 121 IS 7 BP 1136 EP 1144 DI 10.1182/blood-2012-07-446278 PG 9 WC Hematology SC Hematology GA 088XH UT WOS:000314870700017 PM 23258923 ER PT J AU Zhang, BG Li, YJ Liu, R Pritchett, TM Haley, JE Sun, WF AF Zhang, Bingguang Li, Yunjing Liu, Rui Pritchett, Timothy M. Haley, Joy E. Sun, Wenfang TI Extending the Bandwidth of Reverse Saturable Absorption in Platinum Complexes Using Two-Photon-Initiated Excited-State Absorption SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE platinum(II) terpyridine complex; photophysics; excited-state absorption; two-photon absorption; reverse saturable absorption; nonlinear absorbing materials ID PT-ETHYNYL COMPOUND; 2-PHOTON ABSORPTION; CROSS-SECTION; OPTICAL NONLINEARITIES; ORGANIC-MOLECULES; PORPHYRIN DIMERS; PHOTOPHYSICS; DERIVATIVES; DYES; PHTHALOCYANINES AB Pt(II) complexes bearing 4-(7-(benzothiazol-2'-yl)-9,9-diethylfluoren-2-yl)-2,2':6',2 ''-terpyridine or 4-(7-(benzothiazol-2'-yl)-9,9-diethylfluoren-2-yl)ethynyl-2,2':6',2 ''-terpyridine ligand exhibit strong reverse saturable absorption in the visible spectral region and large two-photon initiated excited-state absorption in the near-IR region. They are promising broadband nonlinear absorbing materials from the visible to the near-IR region. The extended pi-conjugation in complex 2 that has a C C linker between the terpyridine ligand and the 4-(7-(benzothiazol-2'-yl)-9,9-diethylfluoren-2-yl) substituent significantly increases the two-photon absorption cross sections (sigma(2)), making it among the strongest of two-photon absorbing Pt(II) complexes. C1 [Zhang, Bingguang; Li, Yunjing; Liu, Rui; Sun, Wenfang] N Dakota State Univ, Dept Chem & Biochem, Fargo, ND 58108 USA. [Pritchett, Timothy M.] USA, Res Lab, AMSRD SEE M, Adelphi, MD 20783 USA. [Haley, Joy E.] USAF, Mat & Mfg Directorate, Res Lab, Dayton, OH 45433 USA. RP Sun, WF (reprint author), N Dakota State Univ, Dept Chem & Biochem, Fargo, ND 58108 USA. EM Wenfang.Sun@ndsu.edu RI Liu, Rui/G-3772-2014 FU Army Research Laboratory [W911NF-06-2-0032, W911NF-10-2-0055]; National Science Foundation [CHE-0449598] FX This work is partially supported by the Army Research Laboratory (Grants W911NF-06-2-0032 and W911NF-10-2-0055). We also acknowledge the support from the National Science Foundation (Grant CAREER CHE-0449598) for partial support. NR 43 TC 17 Z9 17 U1 4 U2 41 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD FEB 13 PY 2013 VL 5 IS 3 BP 565 EP 572 DI 10.1021/am3018724 PG 8 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA 091WE UT WOS:000315079700015 PM 23273050 ER PT J AU Peterson, AM Jensen, RE Palmese, GR AF Peterson, Amy M. Jensen, Robert E. Palmese, Giuseppe R. TI Kinetic Considerations for Strength Recovery at the Fiber-Matrix Interface Based on the Diels-Alder Reaction SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE Diels-Alder reaction; self-healing polymer; fiber-reinforced polymer composite; fiber-matrix interface; thermoset; glass transition temperature ID SHEAR-STRENGTH; POLYMER; EPOXY; COMPOSITES; PERFORMANCE; THERMOSETS; LINKERS; AGENTS; GELS AB The Diels-Alder reaction was used to yield thermal reversibility of the bonding between a partially furan-functionalized epoxy thermosetting matrix and a maleimide-treated glass fiber. Under ambient temperature conditions, the covalent bond forming product reaction dominates, but this reaction reverses at elevated temperatures to allow for interfacial healing. Single-fiber microdroplet pull-out testing was used to characterize the coupled effects of healing temperature and the glass transition temperature (T-g) of the epoxy on interfacial strength recovery. In particular, the roles of mobility and reaction kinetics were independently varied to understand the individual effects of both. C1 [Peterson, Amy M.; Palmese, Giuseppe R.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. [Jensen, Robert E.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Palmese, GR (reprint author), Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. EM palmese@coe.drexel.edu RI Peterson, Amy/A-2945-2012 OI Peterson, Amy/0000-0002-4612-0062 FU U.S. Army Research Laboratory under the Army Materials Center of Excellence Program [W911NF-06-2-0013]; National Science Foundation Graduate Research Fellowship FX This research was supported by the U.S. Army Research Laboratory under the Army Materials Center of Excellence Program, Contract W911NF-06-2-0013. Amy Peterson was supported in part by a National Science Foundation Graduate Research Fellowship. The authors thank the U.S. Army Research Laboratory for use of the single-fiber microdroplet pull-out testing apparatus as well as Daphne Pappas at the US Army Research Laboratory for XPS analysis. NR 30 TC 9 Z9 12 U1 6 U2 61 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD FEB 13 PY 2013 VL 5 IS 3 BP 815 EP 821 DI 10.1021/am302383v PG 7 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA 091WE UT WOS:000315079700047 PM 23317573 ER PT J AU Kumar, R Sides, SW Goswami, M Sumpter, BG Hong, KL Wu, XD Russell, TP Gido, SP Misichronis, K Rangou, S Avgeropoulos, A Tsoukatos, T Hadjichristidis, N Beyer, FL Mays, JW AF Kumar, Rajeev Sides, Scott W. Goswami, Monojoy Sumpter, Bobby G. Hong, Kunlun Wu, Xiaodong Russell, Thomas P. Gido, Samuel P. Misichronis, Konstantinos Rangou, Sofia Avgeropoulos, Apostolos Tsoukatos, Thodoris Hadjichristidis, Nikos Beyer, Frederick L. Mays, Jimmy W. TI Morphologies of ABC Triblock Terpolymer Melts Containing Poly(Cyclohexadiene): Effects of Conformational Asymmetry SO LANGMUIR LA English DT Article ID BLOCK-COPOLYMER MELTS; LIVING ANIONIC-POLYMERIZATION; CONSISTENT-FIELD THEORY; DIBLOCK COPOLYMERS; PHASE-BEHAVIOR; NETWORK PHASES; N-BUTYLLITHIUM/N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE SYSTEM; 1,3-CYCLOHEXADIENE POLYMERS; MICROPHASE SEPARATION; MULTIPHASE MORPHOLOGY AB We have synthesized linear ABC triblock terpolymers containing poly(1,3-cyclohexadiene), PCHD, as an end block and characterized their morphologies in the melt. Specifically, we have studied terpolymers containing polystyrene (PS), polybutadiene (PB), and polyisoprene (PI) as the other blocks. Systematically varying the ratio of 1,2- /1,4-microstructures of poly(1,3-cyclohexadiene), we have studied the effects of conformational asymmetry among the three blocks on the morphologies using transmission electron microscopy (TEM), small-angle X-ray scattering (SAXS), and self-consistent field theory (SCFT) performed with PolySwift++. Our work reveals that the triblock terpolymer melts containing a high percentage of 1,2-microstructures in the PCHD block are disordered at 110 degrees C for all the samples, independent of sequence and volume fraction of the blocks. In contrast, the triblock terpolymer melts containing a high percentage of 1,4-microstructure form regular morphologies known from the literature. The accuracy of the SCFT calculations depends on calculating the chi parameters that quantify the repulsive interactions between different monomers. Simulations using chi values obtained from solubility parameters and group contribution methods are unable to reproduce the morphologies as seen in the experiments. However, SCFT calculations accounting for the enhancement of the chi parameter with an increase in the conformational asymmetry lead to an excellent agreement between theory and experiments. These results highlight the importance of conformational asymmetry in tuning the chi parameter and, in turn, morphologies in block copolymers. C1 [Kumar, Rajeev] Oak Ridge Natl Lab, Natl Ctr Computat Sci, Oak Ridge, TN 37831 USA. [Sides, Scott W.] Tech X Corp, Boulder, CO 80303 USA. [Goswami, Monojoy] Oak Ridge Natl Lab, Comp Sci & Math Div, Oak Ridge, TN 37831 USA. [Sumpter, Bobby G.; Hong, Kunlun] Oak Ridge Natl Lab, Ctr Nanophase Mat Sci, Oak Ridge, TN 37831 USA. [Wu, Xiaodong; Russell, Thomas P.; Gido, Samuel P.] Univ Massachusetts, Polymer Sci & Engn Dept, Amherst, MA 01003 USA. [Misichronis, Konstantinos; Rangou, Sofia; Avgeropoulos, Apostolos] Univ Ioannina, Dept Mat Sci & Engn, GR-45110 Ioannina, Greece. [Tsoukatos, Thodoris; Hadjichristidis, Nikos] Univ Athens Panepistimiopolis, Dept Chem, Athens 15771, Greece. [Beyer, Frederick L.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Mays, Jimmy W.] Univ Tennessee, Dept Chem, Knoxville, TN 37996 USA. RP Kumar, R (reprint author), Oak Ridge Natl Lab, Natl Ctr Computat Sci, Oak Ridge, TN 37831 USA. EM kumarr@ornl.gov RI Sumpter, Bobby/C-9459-2013; Goswami, Monojoy/G-7943-2012; Hong, Kunlun/E-9787-2015; KUMAR, RAJEEV/D-2562-2010; Avgeropoulos, Apostolos/I-5772-2012; Kumar, Rajeev/Q-2255-2015 OI Sumpter, Bobby/0000-0001-6341-0355; Goswami, Monojoy/0000-0002-4473-4888; Hong, Kunlun/0000-0002-2852-5111; Misichronis, Konstantinos/0000-0002-2620-1738; Kumar, Rajeev/0000-0001-9494-3488 FU Materials Science and Engineering Division, U.S. Department of Energy (DoE), Office of Basic Energy Sciences (BES) [DEAC05-00OR22725]; UT-Battelle, LLC, at Oak Ridge National Laboratory (ORNL); Scientific User Facilities Division of DOE FX This work was supported by the Materials Science and Engineering Division, U.S. Department of Energy (DoE), Office of Basic Energy Sciences (BES) under Contract No. DEAC05-00OR22725 with UT-Battelle, LLC, at Oak Ridge National Laboratory (ORNL). Part of the research was done at the Center for Nanophase Materials Sciences, which is sponsored by the Scientific User Facilities Division of DOE. This research used resources of the Oak Ridge Leadership Computing Facility at the ORNL. NR 73 TC 8 Z9 8 U1 5 U2 112 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD FEB 12 PY 2013 VL 29 IS 6 BP 1995 EP 2006 DI 10.1021/la304576c PG 12 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 090ZJ UT WOS:000315018200034 PM 23259866 ER PT J AU Yerry, J Lewis, S Finkel, A AF Yerry, Juanita Lewis, Steven Finkel, Alan TI Safety of Onabotulinum Toxin A for the Treatment of Chronic Post-Traumatic Headache in Service Members with a History of Mild Traumatic Brain Injury SO NEUROLOGY LA English DT Meeting Abstract CT 65th Annual Meeting of the American-Academy-of-Neurology (AAN) CY MAR 16-23, 2013 CL San Diego, CA SP Amer Acad Neurol C1 [Yerry, Juanita; Lewis, Steven] Womack Army Med Ctr, Concuss Care Clin, Ft Bragg, NC USA. [Finkel, Alan] Def & Vet Brain Injury Ctr, Concuss Care Clin, Ft Bragg, NC USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0028-3878 EI 1526-632X J9 NEUROLOGY JI Neurology PD FEB 12 PY 2013 VL 80 SU S MA P01076 PG 1 WC Clinical Neurology SC Neurosciences & Neurology GA AB8VR UT WOS:000332068600233 ER PT J AU Yurek, S DeAngelis, DL Trexler, JC Jopp, F Donalson, DD AF Yurek, Simeon DeAngelis, Donald L. Trexler, Joel C. Jopp, Fred Donalson, Douglas D. TI Simulating mechanisms for dispersal, production and stranding of small forage fish in temporary wetland habitats SO ECOLOGICAL MODELLING LA English DT Article DE Spatially explicit model; Fish movement strategies; Small fish community; Ephemeral habitats; Dynamic biomass distributions; Trophic web structure ID FRESH-WATER MARSH; FLORIDA-EVERGLADES; COMMUNITY STRUCTURE; SPATIOTEMPORAL PATTERNS; OLIGOTROPHIC WETLAND; TROPHIC INTERACTIONS; WADING BIRDS; ECOSYSTEM; RESTORATION; DISTURBANCE AB Movement strategies of small forage fish (<8 cm total length) between temporary and permanent wetland habitats affect their overall population growth and biomass concentrations, i.e., availability to predators. These fish are often the key energy link between primary producers and top predators, such as wading birds, which require high concentrations of stranded fish in accessible depths. Expansion and contraction of seasonal wetlands induce a sequential alternation between rapid biomass growth and concentration, creating the conditions for local stranding of small fish as they move in response to varying water levels. To better understand how landscape topography, hydrology, and fish behavior interact to create high densities of stranded fish, we first simulated population dynamics of small fish, within a dynamic food web, with different traits for movement strategy and growth rate, across an artificial, spatially explicit, heterogeneous, two-dimensional marsh slough landscape, using hydrologic variability as the driver for movement. Model output showed that fish with the highest tendency to invade newly flooded marsh areas built up the largest populations over long time periods with stable hydrologic patterns. A higher probability to become stranded had negative effects on long-term population size, and offset the contribution of that species to stranded biomass. The model was next applied to the topography of a 10 km x 10 km area of Everglades landscape. The details of the topography were highly important in channeling fish movements and creating spatiotemporal patterns of fish movement and stranding. This output provides data that can be compared in the future with observed locations of fish biomass concentrations, or such surrogates as phosphorus 'hotspots' in the marsh. Published by Elsevier B.V. C1 [Yurek, Simeon; DeAngelis, Donald L.] Univ Miami, Dept Biol, Cox Sci Ctr, Coral Gables, FL 33124 USA. [DeAngelis, Donald L.] Univ Miami, US Geol Survey, Southeast Ecol Sci Ctr, Coral Gables, FL 33124 USA. [Trexler, Joel C.] Florida Int Univ, Dept Biol Sci, North Miami, FL 33181 USA. [Donalson, Douglas D.] USA, Corps Engineers, Jacksonville, FL 32202 USA. [Jopp, Fred] Univ Giessen, Dept Anim Ecol, IFZ, D-35392 Giessen, Germany. RP Yurek, S (reprint author), Univ Miami, Dept Biol, Cox Sci Ctr, 1301 Mem Dr, Coral Gables, FL 33124 USA. EM syurek@bio.miami.edu; don_deangelis@usgs.gov; trexlerj@fiu.edu; fred.jopp@gmail.com; douglas.d.donalson@usace.army.mil FU USGS Greater Everglades Priority Ecosystem Science Program; USGS Future Impacts of Sea Level Rise on Coastal Habitats and Species project; Department of the Army [W912HZ-10-2-0033]; U.S. Army Engineer Research and Development Center (ERDC) [W912HZ-10-2-0033]; Florida International University [W912HZ-10-2-0033]; National Science Foundation [DEB-9910514] FX We thank William F. Loftus, Joseph Serafy, and two anonymous reviewers for useful comments and suggestions. S. Yurek was supported by the USGS Greater Everglades Priority Ecosystem Science Program and by the USGS Future Impacts of Sea Level Rise on Coastal Habitats and Species project. J.C. Trexler was supported by cooperative agreement W912HZ-10-2-0033 between the Department of the Army, U.S. Army Engineer Research and Development Center (ERDC) and Florida International University while working on this project. This material was developed in collaboration with the Florida Coastal Everglades Long-Term Ecological Research program under National Science Foundation Grant No. DEB-9910514. Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U. S. Government. NR 57 TC 7 Z9 8 U1 3 U2 41 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3800 J9 ECOL MODEL JI Ecol. Model. PD FEB 10 PY 2013 VL 250 BP 391 EP 401 DI 10.1016/j.ecolmodel.2012.11.001 PG 11 WC Ecology SC Environmental Sciences & Ecology GA 094EP UT WOS:000315246100037 ER PT J AU Salemi, S Goldsman, N Ettisserry, DP Akturk, A Lelis, A AF Salemi, S. Goldsman, N. Ettisserry, D. P. Akturk, A. Lelis, A. TI The effect of defects and their passivation on the density of states of the 4H-silicon-carbide/silicon-dioxide interface SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID SIC/SIO2 INTERFACE; NITRIDATION; N2O AB The 4H-SiC(0001)/SiO2 interface has a variety of likely defects as reported in the literature. We investigate the defects at the SiC side of the interface using density functional theory. We also investigate the effects of passivating these states. The defects studied include a single carbon interstitial, a carbon pair interstitial, and a silicon vacancy at the interface. Density functional theory has been employed to calculate the total and projected density of states (pDOS) and the energy levels of the defects. The results of our calculations indicate that a carbon interstitial and a pair of carbons give rise to traps near the conduction band and valence band. The silicon vacancy gives rise to traps that are closer to the valence band. The effects of hydrogen and nitrogen passivation on the defect energy levels have been investigated. Our studies indicate that hydrogen and nitrogen passivation can eliminate states near the conduction and valence bands, although in some cases they may introduce levels in the midgap. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4789615] C1 [Salemi, S.] Univ Maryland, Dept Reliabil Engn, College Pk, MD 20742 USA. [Goldsman, N.; Ettisserry, D. P.; Akturk, A.] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. [Lelis, A.] USA, Res Lab, Adelphi, MD 20783 USA. RP Goldsman, N (reprint author), Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. EM neil@umd.edu OI Ettisserry, Devanarayanan/0000-0002-4214-2141 NR 21 TC 8 Z9 8 U1 1 U2 43 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD FEB 7 PY 2013 VL 113 IS 5 AR 053703 DI 10.1063/1.4789615 PG 6 WC Physics, Applied SC Physics GA 087FH UT WOS:000314746200032 ER PT J AU Barault, L Ellsworth, RE Harris, HR Valente, AL Shriver, CD Michels, KB AF Barault, Ludovic Ellsworth, Rachel E. Harris, Holly R. Valente, Allyson L. Shriver, Craig D. Michels, Karin B. TI Leukocyte DNA as Surrogate for the Evaluation of Imprinted Loci Methylation in Mammary Tissue DNA SO PLOS ONE LA English DT Article ID GROWTH-FACTOR-II; COLORECTAL-CANCER; BREAST-CANCER; IGF2 GENE; EXPRESSION; H19; HYPOMETHYLATION; STABILITY; PATTERNS; DISEASE AB There is growing interest in identifying surrogate tissues to identify epimutations in cancer patients since primary target tissues are often difficult to obtain. Methylation patterns at imprinted loci are established during gametogenesis and post fertilization and their alterations have been associated with elevated risk of cancer. Methylation at several imprinted differentially methylated regions (GRB10 ICR, H19 ICR, KvDMR, SNRPN/SNURF ICR, IGF2 DMR0, and IGF2 DMR2) were analyzed in DNA from leukocytes and mammary tissue (normal, benign diseases, or malignant tumors) from 87 women with and without breast cancer (average age of cancer patients: 53; range: 31-77). Correlations between genomic variants and DNA methylation at the studied loci could not be assessed, making it impossible to exclude such effects. Methylation levels observed in leukocyte and mammary tissue DNA were close to the 50% expected for monoallellic methylation. While no correlation was observed between leukocyte and mammary tissue DNA methylation for most of the analyzed imprinted genes, Spearman's correlations were statistically significant for IGF2 DMR0 and IGF2 DMR2, although absolute methylation levels differed. Leukocyte DNA methylation levels of selected imprinted genes may therefore serve as surrogate markers of DNA methylation in cancer tissue. C1 [Barault, Ludovic; Harris, Holly R.; Michels, Karin B.] Harvard Univ, Brigham & Womens Hosp, Obstet & Gynecol Epidemiol Ctr, Sch Med,Dept Obstet Gynecol & Reprod Biol, Boston, MA 02115 USA. [Ellsworth, Rachel E.] Henry M Jackson Fdn Adv Mil Med, Clin Breast Care Project, Windber, PA USA. [Valente, Allyson L.] Windber Res Inst, Clin Breast Care Project, Windber, PA USA. [Shriver, Craig D.] Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC 20307 USA. [Michels, Karin B.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. RP Barault, L (reprint author), Harvard Univ, Brigham & Womens Hosp, Obstet & Gynecol Epidemiol Ctr, Sch Med,Dept Obstet Gynecol & Reprod Biol, Boston, MA 02115 USA. EM Ludovic.barault@ircc.it RI Barault, Ludovic/J-2472-2016 OI Barault, Ludovic/0000-0001-5227-5047 FU National Cancer Institute, National Institutes of Health, Department of Health and Human Services [R03CA143967]; Breast Cancer Research Foundation FX This work was supported by a research grant from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services [R03CA143967 to KBM]; and the Breast Cancer Research Foundation (to KBM). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 36 TC 6 Z9 6 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 7 PY 2013 VL 8 IS 2 AR e55896 DI 10.1371/journal.pone.0055896 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 092XV UT WOS:000315157200084 PM 23409079 ER PT J AU Mac Donald, C Johnson, A Cooper, D Malone, T Sorrell, J Shimony, J Parsons, M Snyder, A Raichle, M Fang, R Flaherty, S Russell, M Brody, DL AF Mac Donald, Christine Johnson, Ann Cooper, Dana Malone, Thomas Sorrell, James Shimony, Joshua Parsons, Matthew Snyder, Abraham Raichle, Marcus Fang, Raymond Flaherty, Stephen Russell, Michael Brody, David L. TI Cerebellar White Matter Abnormalities following Primary Blast Injury in US Military Personnel SO PLOS ONE LA English DT Article ID TRAUMATIC BRAIN-INJURY; POSTTRAUMATIC-STRESS-DISORDER; EXPLOSIVE BLAST; WAR VETERANS; HEAD-INJURY; EXPOSURE; SEQUELAE; COMBAT; SCALE; IRAQI AB Little is known about the effects of blast exposure on the human brain in the absence of head impact. Clinical reports, experimental animal studies, and computational modeling of blast exposure have suggested effects on the cerebellum and brainstem. In US military personnel with isolated, primary blast-related 'mild' traumatic brain injury and no other known insult, we found diffusion tensor MRI abnormalities consistent with cerebellar white matter injury in 3 of 4 subjects. No abnormalities in other brain regions were detected. These findings add to the evidence supporting the hypothesis that primary blast exposure contributes to brain injury in the absence of head impact and that the cerebellum may be particularly vulnerable. However, the clinical effects of these abnormalities cannot be determined with certainty; none of the subjects had ataxia or other detected evidence of cerebellar dysfunction. The details of the blast events themselves cannot be disclosed at this time, thus additional animal and computational modeling will be required to dissect the mechanisms underlying primary blast-related traumatic brain injury. Furthermore, the effects of possible subconcussive impacts and other military-related exposures cannot be determined from the data presented. Thus many aspects of topic will require further investigation. C1 [Mac Donald, Christine; Johnson, Ann; Cooper, Dana; Malone, Thomas; Sorrell, James; Brody, David L.] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA. [Shimony, Joshua; Parsons, Matthew; Snyder, Abraham; Raichle, Marcus] Washington Univ, Sch Med, Dept Radiol, St Louis, MO 63110 USA. [Fang, Raymond; Flaherty, Stephen] Landstuhl Reg Med Ctr, Dept Trauma Surg, Landstuhl, Germany. [Russell, Michael] USA, Rehabil & Reintegrat Div, San Antonio, TX USA. RP Brody, DL (reprint author), Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA. EM brodyd@neuro.wustl.edu FU Congressionally Directed Medical Research Program [W81XWH-08-2-0061]; United States National Institutes of Health [F32NS062529, 5K23HD053212, P30NS048056, P50NS06833, 5K08NS49237]; U.S. Army Medical Research Acquisition Activity [W81XWH-09-2-0057] FX The study was supported by grants from the Congressionally Directed Medical Research Program (W81XWH-08-2-0061, to Dr. Brody), the United States National Institutes of Health (F32NS062529, to Dr. Mac Donald; 5K23HD053212, to Dr. Shimony; P30NS048056, to Dr. Snyder; P50NS06833, to Drs. Raichle and Snyder; and 5K08NS49237, to Dr. Brody) and U.S. Army Medical Research Acquisition Activity (W81XWH-09-2-0057) to Dr. Russell, under a protocol approved by Brooke Army Medical Center, San Antonio, TX. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 53 TC 20 Z9 20 U1 1 U2 15 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 7 PY 2013 VL 8 IS 2 AR e55823 DI 10.1371/journal.pone.0055823 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 092XV UT WOS:000315157200070 PM 23409052 ER PT J AU Beaudet, TD Mattson, WD Rice, BM AF Beaudet, Todd D. Mattson, William D. Rice, Betsy M. TI New form of polymeric nitrogen from dynamic shock simulation SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID SPACE GAUSSIAN PSEUDOPOTENTIALS; SOLID MOLECULAR NITROGEN; VIBRATIONAL DYNAMICS; HIGH-PRESSURES; PHASE; GPA; TRANSFORMATION; CRYSTALLINE; MBAR AB For many years there has been significant interest in polymeric phases of nitrogen at low pressure for potential application as an energetic material. This was the result of years of theoretical work indicating potentially meta-stable polymeric nitrogen. Experimental evidence of both an amorphous phase and a cubic-gauche phase has added greatly to this interest [A. F. Goncharov, E. A. Gregoryanz, H. K. Mao, Z. Liu, and R. J. Hemley, Phys. Rev. Lett. 85, 1262 (2000); M. I. Eremets, R. J. Hemley, H. K. Mao, and E. Gregoryanz, Nature (London) 411, 170 (2001)]. While most of the theoretical work has been done on the many crystal phases of nitrogen, little work has been done on simulating amorphous polymeric nitrogen. The original goal of this work was to simulate amorphous polymeric nitrogen at low pressure; however, we unexpectedly found a new form of polymeric nitrogen. Starting from first principles dynamic shock simulation of cubic-gauche nitrogen [W. D. Mattson and R. Balu, Phys. Rev. B 83, 174105 (2011)] we demonstrate a new low pressure porous form that exhibits stability at low temperatures. We describe the detailed procedure of obtaining this structure as well as some of its physical characteristics. Finally, we explore composite structures of this new form of polymeric nitrogen and their possible relationship to an amorphous form. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4789307] C1 [Beaudet, Todd D.; Mattson, William D.; Rice, Betsy M.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Beaudet, TD (reprint author), USA, Res Lab, RDRL WMM E Bldg 4600, Aberdeen Proving Ground, MD 21005 USA. FU U.S. Army Research Laboratory FX Calculations were performed using the DOD Supercomputing Resource Centers (DSRCs) located at the U.S. Army Research Laboratory and the Air Force Research Laboratory administered by the DOD High Performance Computing Modernization Program. This research was supported in part by an appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a contract with the U.S. Army Research Laboratory. The authors thank Dr. Edward F. C. Byrd, Dr. DeCarlos Taylor, and Dr. Tanya Chantawansri of the Army Research Laboratory for helpful discussions. NR 61 TC 7 Z9 8 U1 3 U2 53 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-9606 EI 1089-7690 J9 J CHEM PHYS JI J. Chem. Phys. PD FEB 7 PY 2013 VL 138 IS 5 AR 054503 DI 10.1063/1.4789307 PG 8 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 087FJ UT WOS:000314746400040 PM 23406129 ER PT J AU Ben Salah, A Ben Messaoud, N Guedri, E Zaatour, A Ben Alaya, N Bettaieb, J Gharbi, A Hamida, NB Boukthir, A Chlif, S Abdelhamid, K El Ahmadi, Z Louzir, H Mokni, M Morizot, G Buffet, P Smith, PL Kopydlowski, KM Kreishman-Deitrick, M Smith, KS Nielsen, CJ Ullman, DR Norwood, JA Thorne, GD McCarthy, WF Adams, RC Rice, RM Tang, D Berman, J Ransom, J Magill, AJ Grogl, M AF Ben Salah, Afif Ben Messaoud, Nathalie Guedri, Evelyn Zaatour, Amor Ben Alaya, Nissaf Bettaieb, Jihene Gharbi, Adel Hamida, Nabil Belhadj Boukthir, Aicha Chlif, Sadok Abdelhamid, Kidar El Ahmadi, Zaher Louzir, Hechmi Mokni, Mourad Morizot, Gloria Buffet, Pierre Smith, Philip L. Kopydlowski, Karen M. Kreishman-Deitrick, Mara Smith, Kirsten S. Nielsen, Carl J. Ullman, Diane R. Norwood, Jeanne A. Thorne, George D. McCarthy, William F. Adams, Ryan C. Rice, Robert M. Tang, Douglas Berman, Jonathan Ransom, Janet Magill, Alan J. Grogl, Max TI Topical Paromomycin with or without Gentamicin for Cutaneous Leishmaniasis SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; AMINOSIDINE PAROMOMYCIN; OINTMENT; THERAPY AB Background There is a need for a simple and efficacious treatment for cutaneous leishmaniasis with an acceptable side-effect profile. Methods We conducted a randomized, vehicle-controlled phase 3 trial of topical treatments containing 15% paromomycin, with and without 0.5% gentamicin, for cutaneous leishmaniasis caused by Leishmania major in Tunisia. We randomly assigned 375 patients with one to five ulcerative lesions from cutaneous leishmaniasis to receive a cream containing 15% paromomycin-0.5% gentamicin (called WR 279,396), 15% paromomycin alone, or vehicle control (with the same base as the other two creams but containing neither paromomycin nor gentamicin). Each lesion was treated once daily for 20 days. The primary end point was the cure of the index lesion. Cure was defined as at least 50% reduction in the size of the index lesion by 42 days, complete reepithelialization by 98 days, and absence of relapse by the end of the trial (168 days). Any withdrawal from the trial was considered a treatment failure. Results The rate of cure of the index lesion was 81% (95% confidence interval [CI], 73 to 87) for paromomycin-gentamicin, 82% (95% CI, 74 to 87) for paromomycin alone, and 58% (95% CI, 50 to 67) for vehicle control (P<0.001 for each treatment group vs. the vehicle-control group). Cure of the index lesion was accompanied by cure of all other lesions except in five patients, one in each of the paromomycin groups and three in the vehicle-control group. Mild-to-moderate application-site reactions were more frequent in the paromomycin groups than in the vehicle-control group. Conclusions This trial provides evidence of the efficacy of paromomycin-gentamicin and paromomycin alone for ulcerative L. major disease. (Funded by the Department of the Army; ClinicalTrials.gov number, NCT00606580.) C1 [Ben Salah, Afif; Ben Messaoud, Nathalie; Guedri, Evelyn; Zaatour, Amor; Ben Alaya, Nissaf; Bettaieb, Jihene; Gharbi, Adel; Hamida, Nabil Belhadj; Boukthir, Aicha; Chlif, Sadok; Louzir, Hechmi] Inst Pasteur Tunis, Tunis, Tunisia. [Mokni, Mourad] Univ Hosp la Rabta, Dept Dermatol, Tunis, Tunisia. [Abdelhamid, Kidar] Reg Hosp Gafsa, Gafsa, Tunisia. [El Ahmadi, Zaher] Reg Directorate Hlth, Sidi Bouzid, Tunisia. [Morizot, Gloria; Buffet, Pierre] Inst Pasteur, Paris, France. [Buffet, Pierre] Univ Paris 06, INSERM, Unite Mixte Rech S 945, Paris, France. [Smith, Philip L.; Kopydlowski, Karen M.; Kreishman-Deitrick, Mara; Smith, Kirsten S.; Nielsen, Carl J.; Ullman, Diane R.; Norwood, Jeanne A.; Thorne, George D.; McCarthy, William F.; Adams, Ryan C.; Rice, Robert M.] USA, Ft Detrick, MD USA. [Tang, Douglas; Berman, Jonathan; Ransom, Janet] Fast Track Drugs & Biol, N Potomac, MD USA. [Magill, Alan J.; Grogl, Max] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Grogl, M (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM max.grogl@amedd.army.mil FU Department of the Army; U.S.-French-Tunisia collaboration; U.S. Army Medical Materiel Development Activity; Institut Pasteur, Paris; U.S. Army Medical Research and Materiel Command; Walter Reed Army Institute of Research FX Supported by the Department of the Army. The investigators have adhered to the policies for protection of human subjects as prescribed in Army Regulation 70-25.; We thank the Regional Directorates of Health of Sidi Bouzid, Kairouan, and Gafsa, Tunisia; Farhat Mighri, Primary Health Center, El Mnara, Tunisia; the World Health Organization Reference Laboratory, Montpellier, France, for characterization of all isolated leishmania parasites; Prof. Dellagi Koussay, M. D., for his support of the U.S.-French-Tunisia collaboration; the Institut Pasteur, Paris, for management of the Cooperative Agreement between the U.S. Army Medical Materiel Development Activity and the Institut Pasteur; William Ellis, for ensuring investigational product transport and import in accordance with current Good Manufacturing Practice guidelines; Shirley Roach and Denise McKinney for clinical monitoring; senior leaders of the U.S. Army Medical Materiel Development Activity, U.S. Army Medical Research and Materiel Command, and Walter Reed Army Institute of Research for their support; and the volunteers for their participation and the parents who allowed their children to participate in the study. NR 29 TC 54 Z9 54 U1 3 U2 26 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD FEB 7 PY 2013 VL 368 IS 6 BP 524 EP 532 DI 10.1056/NEJMoa1202657 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA 083VU UT WOS:000314494100003 PM 23388004 ER PT J AU Vento, TJ Cole, DW Mende, K Calvano, TP Rini, EA Tully, CC Zera, WC Guymon, CH Yu, X Cheatle, KA Akers, KS Beckius, ML Landrum, ML Murray, CK AF Vento, Todd J. Cole, David W. Mende, Katrin Calvano, Tatjana P. Rini, Elizabeth A. Tully, Charla C. Zera, Wendy C. Guymon, Charles H. Yu, Xin Cheatle, Kristelle A. Akers, Kevin S. Beckius, Miriam L. Landrum, Michael L. Murray, Clinton K. TI Multidrug-resistant gram-negative bacteria colonization of healthy US military personnel in the US and Afghanistan SO BMC INFECTIOUS DISEASES LA English DT Article DE Deployment; Malaria chemoprophylaxis; Environment exposure; ESBL-production; Escherichia coli ID INFECTIOUS-DISEASES SOCIETY; SPECTRUM BETA-LACTAMASES; COMBAT-RELATED INJURIES; ESCHERICHIA-COLI; FECAL FLORA; KLEBSIELLA-PNEUMONIAE; HOSPITALIZED-PATIENTS; RISK-FACTORS; TETRACYCLINE; DOXYCYCLINE AB Background: The US military has seen steady increases in multidrug-resistant (MDR) gram-negative bacteria (GNB) infections in casualties from Iraq and Afghanistan. This study evaluates the prevalence of MDR GNB colonization in US military personnel. Methods: GNB colonization surveillance of healthy, asymptomatic military personnel (101 in the US and 100 in Afghanistan) was performed by swabbing 7 anatomical sites. US-based personnel had received no antibiotics within 30 days of specimen collection, and Afghanistan-based personnel were receiving doxycycline for malaria chemoprophylaxis at time of specimen collection. Isolates underwent genotypic and phenotypic characterization. Results: The only colonizing MDR GNB recovered in both populations was Escherichia coli (p=0.01), which was seen in 2% of US-based personnel (all perirectal) and 11% of Afghanistan-based personnel (10 perirectal, 1 foot+groin). Individuals with higher off-base exposures in Afghanistan did not show a difference in overall GNB colonization or MDR E. coli colonization, compared with those with limited off-base exposures. Conclusion: Healthy US- and Afghanistan-based military personnel have community onset-MDR E. coli colonization, with Afghanistan-based personnel showing a 5.5-fold higher prevalence. The association of doxycycline prophylaxis or other exposures with antimicrobial resistance and increased rates of MDR E. coli colonization needs further evaluation. C1 [Vento, Todd J.; Mende, Katrin; Calvano, Tatjana P.; Rini, Elizabeth A.; Tully, Charla C.; Zera, Wendy C.; Yu, Xin; Cheatle, Kristelle A.; Akers, Kevin S.; Beckius, Miriam L.; Landrum, Michael L.; Murray, Clinton K.] San Antonio Mil Med Ctr, Brooke Army Med Ctr, Ft Sam Houston, TX USA. [Vento, Todd J.; Akers, Kevin S.; Murray, Clinton K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Cole, David W.] Blanchfield Army Community Hosp, Ft Campbell, KY USA. [Mende, Katrin; Zera, Wendy C.; Landrum, Michael L.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Guymon, Charles H.; Akers, Kevin S.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Murray, CK (reprint author), San Antonio Mil Med Ctr, Brooke Army Med Ctr, Ft Sam Houston, TX USA. EM clinton.murray@us.army.mil RI Valle, Ruben/A-7512-2013 FU Armed Forces Health Surveillance Center; Global Emerging Infectious System FX The views expressed herein are those of the authors and do not reflect the official policy or position of the Department of the Army, Department of the Air Force, Department of Defense, or the US Government. The authors are employees of the US government. This work was prepared as part of their official duties and, as such, there is no copyright to be transferred. This work was supported by the Armed Forces Health Surveillance Center including the Global Emerging Infectious System. NR 34 TC 16 Z9 16 U1 2 U2 7 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD FEB 5 PY 2013 VL 13 AR 68 DI 10.1186/1471-2334-13-68 PG 11 WC Infectious Diseases SC Infectious Diseases GA 113SL UT WOS:000316688600001 PM 23384348 ER PT J AU Jiang, HB Holtz, LR Bauer, I Franz, CJ Zhao, GY Bodhidatta, L Shrestha, SK Kang, G Wang, D AF Jiang, Hongbing Holtz, Lori R. Bauer, Irma Franz, Carl J. Zhao, Guoyan Bodhidatta, Ladaporn Shrestha, Sanjaya K. Kang, Gagandeep Wang, David TI Comparison of novel MLB-clade, VA-clade and classic human astroviruses highlights constrained evolution of the classic human astrovirus nonstructural genes SO VIROLOGY LA English DT Article DE Astrovirus discovery; Diarrhea; Nonstructural genes; Constrained evolution ID MOLECULAR CHARACTERIZATION; MAXIMUM-LIKELIHOOD; CHILDREN; GASTROENTERITIS; DIVERSITY; DIARRHEA AB Eight serotypes of human astroviruses (the classic human astroviruses) are causative agents of diarrhea. Recently, five additional astroviruses belonging to two distinct clades have been described in human stool, including astroviruses MLB1, MLB2, VA1, VA2 and VA3. We report the discovery in human stool of two novel astroviruses, astroviruses MLB3 and VA4. The complete genomes of these two viruses and the previously described astroviruses VA2 and VA3 were sequenced, affording seven complete genomes from the MLB and VA clades for comparative analysis to the classic human astroviruses. Comparison of the genetic distance, number of synonymous mutations per synonymous site (dS), number of non-synonymous mutations per non-synonymous site (dN) and the dN/dS ratio in the protease, polymerase and capsid of the classic human, MLB and VA clades suggests that the protease and polymerase of the classic human astroviruses are under distinct selective pressure. (C) 2012 Elsevier Inc. All rights reserved. C1 [Jiang, Hongbing; Bauer, Irma; Franz, Carl J.; Zhao, Guoyan; Wang, David] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA. [Holtz, Lori R.] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA. [Bodhidatta, Ladaporn] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand. [Shrestha, Sanjaya K.] Walter Reed AFRIMS Res Unit Nepal, Kathmandu, Nepal. [Kang, Gagandeep] Christian Med Coll & Hosp, Dept Gastrointestinal Sci, Vellore, Tamil Nadu, India. RP Wang, D (reprint author), Washington Univ, Sch Med, Dept Mol Microbiol, 660 S Euclid Ave, St Louis, MO 63110 USA. EM davewang@borcim.wustl.edu RI Valle, Ruben/A-7512-2013; OI Kang, Gagandeep/0000-0002-3656-564X; Holtz, Lori/0000-0002-5591-7794 FU NIH [U54 AI057160, R21 AI090199]; Burroughs Wellcome Fund; NIH-National Center for Advancing Translational Sciences [UL1 TR000448, KL2 TR000450] FX This work was supported in part by NIH grant U54 AI057160 to the Midwest Regional Center of Excellence for Biodefense and Emerging Infectious Disease Research and NIH grant R21 AI090199. D.W. holds an Investigator in the Pathogenesis of Infectious Disease Award from the Burroughs Wellcome Fund. LRH is supported by UL1 TR000448 sub award KL2 TR000450 from the NIH-National Center for Advancing Translational Sciences. NR 27 TC 25 Z9 25 U1 0 U2 5 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD FEB 5 PY 2013 VL 436 IS 1 BP 8 EP 14 DI 10.1016/j.virol.2012.09.040 PG 7 WC Virology SC Virology GA 077BV UT WOS:000314003800002 PM 23084422 ER PT J AU La Scala, J Wool, RP AF La Scala, John Wool, Richard P. TI Fundamental thermo-mechanical property modeling of triglyceride-based thermosetting resins SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article DE crosslinking; glass transition; thermosets; renewable resources; relaxation ID DIELECTRIC RELAXATION BEHAVIOUR; EMPIRICAL DECAY FUNCTION; FATTY-ACID COMPOSITION; VINYL-ESTER; MECHANICAL-PROPERTIES; SEGMENTAL RELAXATION; CURE KINETICS; POLYMERS; TEMPERATURE; NETWORKS AB The glass transition temperature (T-g) of acrylated triglycerides was clearly a function of the level of acrylation of triglyceride-based polymers and was modeled using simple empirical relationships. We began by calculating the distribution of unsaturation sites in plant oils. We assumed a binomial distribution of chemical functionality that was added to these unsaturation sites to calculate the distribution of epoxides, acrylates, and reacted acrylates to predict the crosslink density, thermal softening, and dynamic mechanical behavior. The glass transition temperatures of n-acrylated triglycerides were used as the relaxation temperatures of acrylated oils with a broad distribution of functionality for prediction of the modulus as a function of temperature. Essentially, the percent drop in the elastic modulus is equal to the percentage of n-acrylated triglycerides in the acrylated oil with T-g less than that of the ambient temperature. The tan (delta) was also accurately predicted based on the percentage change of n-functional triglycerides as the temperature changes from one relaxation temperature to the next. (c) 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 127: 1812-1826, 2013 C1 [La Scala, John] USA, Res Lab, RDRL WMM C, Dept Army, Aberdeen Proving Ground, MD 21005 USA. [La Scala, John; Wool, Richard P.] Univ Delaware, Dept Chem Engn, Newark, DE 19716 USA. RP La Scala, J (reprint author), USA, Res Lab, RDRL WMM C, Dept Army, Aberdeen Proving Ground, MD 21005 USA. EM john.j.lascala.civ@mail.mil FU Army Research Laboratory; University of Delaware Army Materials Center of Excellence; NSF; EPA; DoE FX This work was supported by Army Research Laboratory, the University of Delaware Army Materials Center of Excellence, NSF, EPA, and DoE for funding. The authors thank DuPont for providing the genetically engineered high oleic soybean oil and the ACRES group at the University of Delaware for helpful discussions. NR 39 TC 8 Z9 8 U1 2 U2 27 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0021-8995 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD FEB 5 PY 2013 VL 127 IS 3 BP 1812 EP 1826 DI 10.1002/app.37927 PG 15 WC Polymer Science SC Polymer Science GA 030XJ UT WOS:000310603100048 ER PT J AU Thellen, C Cheney, S Ratto, JA AF Thellen, Christopher Cheney, Sarah Ratto, Jo Ann TI Melt processing and characterization of polyvinyl alcohol and polyhydroxyalkanoate multilayer films SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article DE polyvinyl alcohol; polyhydroxyalkanoate; barrier; coextrusion; multilayer films; permeation ID BIODEGRADATION; POLY(3-HYDROXYBUTYRATE); PERMEATION AB Multilayer films for food packaging applications composed of polyvinyl alcohol (PVOH) as the core layer and polyhydroxyalkanoate (PHA) as the outer skin layers were produced by the co-extrusion process. Rheological properties of PVOH and PHA were performed and analyzed before co-extruding into a cast film. Analysis of the rheological data indicated the processing temperatures and grades of the PVOH and PHA polymers that would produce similar viscosity and melt flow properties. To improve adhesion of the layers, PHA was grafted with maleic anhydride using a dicumyl peroxide initiator to provide a tie layer material, which improved the peel strength of the PHA and PVOH layers by over 2x. Oxygen transmission rate (OTR) testing showed that the multilayer sample provided an OTR of 27 cc/m(2)-day at 0% relative humidity (RH) and rates of 41 and 52 cc/m(2)-day at relative humidity values of 60% and 90% RH, respectively. This indicates significant barrier performance enhancement over monolayer PVOH that provided an OTR of 60 cc/m(2)-day at 0% RH and 999 cc/m(2)-day at 60% RH. Biodegradation testing of the films in the marine environment showed that both the unmodified and maleated PHA polymers displayed high levels of mineralization, whereas the PVOH material did not. (c) 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013 C1 [Thellen, Christopher; Cheney, Sarah; Ratto, Jo Ann] USA, Combat Feeding Directorate, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Thellen, C (reprint author), USA, Combat Feeding Directorate, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. EM christopher.t.thellen.civ@mail.mil FU U.S. Navy Waste Reduction Afloat Protects the Sea (WRAPS) program FX The authors thank the U.S. Navy Waste Reduction Afloat Protects the Sea (WRAPS) program, especially Mr. Jeff Whitman, Mr. John Bendick, and Mr. Trey Kunkel, for funding the research discussed in this article. A special acknowledgement goes to Dr. Robert Whitehouse of Metabolix Inc., Professor Daniel Schmidt, and Professor Stephen McCarthy of the University of Massachusetts Lowell for working with the NSRDEC on this project and supplying their knowledge and expertise in the area of PHA polymers. Heather Scaglione of A. Schulman, Ken Kumaki of Kuraray, and Terrence Cooper are also acknowledged for providing PVOH sample materials along with their experience in the area of PVOH films and processing. They also thank Dr. Joel Carlson and Ms. Diane Steeves for their FTIR and NMR expertise, as well as Ms. Danielle Froio, Mr. Matthew Bernasconi, Mr. Christopher Hope, and Ms. Jeanne Lucciarini of the NSRDEC for all of their efforts in relation to this research. This research could not have been accomplished without their efforts. NR 40 TC 9 Z9 9 U1 5 U2 61 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0021-8995 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD FEB 5 PY 2013 VL 127 IS 3 BP 2314 EP 2324 DI 10.1002/app.37850 PG 11 WC Polymer Science SC Polymer Science GA 030XJ UT WOS:000310603100106 ER PT J AU Shoop, SA Sandu, C Ayers, P AF Shoop, Sally A. Sandu, Corina Ayers, Paul TI Introduction: Best papers from the 50th Anniversary ISTVS Conference SO JOURNAL OF TERRAMECHANICS LA English DT Editorial Material C1 [Shoop, Sally A.] Erdc, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Sandu, Corina] Virginia Tech, Blacksburg, VA USA. [Ayers, Paul] Univ Tennessee, Knoxville, TN USA. RP Shoop, SA (reprint author), Erdc, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Sally.a.shoop@usace.army.mil; csandu@vt.edu; ayers@utk.edu NR 10 TC 0 Z9 0 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 J9 J TERRAMECHANICS JI J. Terramech. PD FEB PY 2013 VL 50 IS 1 SI SI BP 3 EP 4 DI 10.1016/j.jterra.2013.03.002 PG 2 WC Engineering, Environmental SC Engineering GA 146LL UT WOS:000319092500001 ER PT J AU Shoop, S Knuth, M Wieder, W AF Shoop, S. Knuth, M. Wieder, W. TI Measuring vehicle impacts on snow roads SO JOURNAL OF TERRAMECHANICS LA English DT Article DE Strength; Disturbance; Rut; Rammsonde; Clegg; Maneuver; Turning; Corner; Speed AB The snow roads at McMurdo Station are the primary transport corridors to move personnel and material from the airfields servicing intra- and inter-continental air traffic for resupply. Thus, they are a critical transportation component and are particularly susceptible to deterioration during the warmest parts of the austral summer when above-freezing temperatures can occur for several days at a time. This study served to explore methodology that could quantify the impact of various vehicles, tires, driving speeds and maneuvers on the snow road conditions. Basic maneuvers were used to isolate the impact of turning, acceleration, braking and speed using spirals, circles, and straight-line testing on a flat, smooth snow pavement. In addition, a road course was set up to include corners and roughness using portions of the active snow roads for more realistic conditions. Measurements included snow surface strength both in and between tire tracks, tire track rut depth and width, and the height and width of the resulting snow piles adjacent to the tire tracks. Results indicate the impacts of driving speed and vehicle type including the importance of the tire and suspension components for preserving the road surfaces through the melt season. Since this type of testing had not been done on snow before, or using these vehicle types, the experiments yielded valuable guidance regarding what types of maneuvers, test surfaces, and measurements could most easily differentiate performance. Published by Elsevier Ltd. on behalf of ISTVS. C1 [Shoop, S.; Knuth, M.] USA, Cold Reg Res & Engn Lab, Engn Res & Dev Ctr, Hanover, NH 03755 USA. [Wieder, W.] Sci & Technol Corp, Hampton, VA 23666 USA. RP Shoop, S (reprint author), USA, Cold Reg Res & Engn Lab, Engn Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA. EM Sally.a.shoop@usace.army.mil FU National Science Foundation Office of Polar Programs; CRREL; Fleet Operations Ice Shelf Crew; Shuttle Transportation Crew of Raytheon Polar Service Corp. FX The authors thanks the following personnel for their extra efforts and assistance with the funding, preparations, testing and measurements: Mr. George Blaisdell of the National Science Foundation Office of Polar Programs; Ms. Rosa Affleck of CRREL; Mr. Christopher Tomac, Mr. Alan Shaw, Ms. Julia Uberuaga, and Mr. William Sundee, from the Fleet Operations Ice Shelf Crew and the Shuttle Transportation Crew of Raytheon Polar Service Corp. NR 12 TC 2 Z9 2 U1 1 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 J9 J TERRAMECHANICS JI J. Terramech. PD FEB PY 2013 VL 50 IS 1 SI SI BP 63 EP 71 DI 10.1016/j.jterra.2013.01.004 PG 9 WC Engineering, Environmental SC Engineering GA 146LL UT WOS:000319092500007 ER PT J AU Newman, RA Kamimori, GH Wesensten, NJ Picchioni, D Balkin, TJ AF Newman, Rachel A. Kamimori, Gary H. Wesensten, Nancy J. Picchioni, Dante Balkin, Thomas J. TI CAFFEINE GUM MINIMIZES SLEEP INERTIA SO PERCEPTUAL AND MOTOR SKILLS LA English DT Article ID HUMAN-PERFORMANCE; ALERTNESS; ADENOSINE; VIGILANCE; RESTRICTION; DEPRIVATION; DISRUPTION; AWAKENINGS; OPERATIONS; PLACEMENT AB Naps are an effective strategy for maintaining alertness and cognitive performance; however, upon abrupt wakening from naps, sleep inertia (temporary performance degradation) may ensue. In the present study, attenuation of post-nap sleep inertia was attempted by administration of caffeine gum. Using a double-blind, placebo-controlled crossover design, 15 healthy, non-smoking adults were awakened at 1 hr. and again at 6 hr. after lights out (0100 and 0600, respectively) and were immediately administered a gum pellet containing 100 mg of caffeine or placebo. A 5-min. psychomotor vigilance task was administered at 0 min., 6 min., 12 min., and 18 min. post-awakening. At 0100, response speed with caffeine was significantly better at 12 min. and 18 min. post-awakening compared to placebo; at 0600, caffeine's effects were evident at 18 min. post-awakening. Caffeinated gum is a viable means of rapidly attenuating sleep inertia, suggesting that the adenosine receptor system is involved in sleep maintenance. C1 [Newman, Rachel A.; Kamimori, Gary H.; Wesensten, Nancy J.; Picchioni, Dante; Balkin, Thomas J.] Walter Reed Army Inst Res, Dept Behav Biol, Ctr Mil Psychiat & Neurosci Res, Silver Spring, MD USA. RP Newman, RA (reprint author), WRAIR 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Rachel.Newman@us.army.mil NR 32 TC 9 Z9 9 U1 3 U2 12 PU AMMONS SCIENTIFIC, LTD PI MISSOULA PA PO BOX 9229, MISSOULA, MT 59807-9229 USA SN 0031-5125 J9 PERCEPT MOTOR SKILL JI Percept. Mot. Skills PD FEB PY 2013 VL 116 IS 1 BP 280 EP 293 DI 10.2466/29.22.25.PMS.116.1.280-293 PG 14 WC Psychology, Experimental SC Psychology GA 142IS UT WOS:000318791400026 PM 23829154 ER PT J AU Chang, MP Fok, M Hofmaier, A Prucnal, PR AF Chang, Matthew P. Fok, Mable Hofmaier, Andrew Prucnal, Paul R. TI Optical Analog Self-Interference Cancellation Using Electro-Absorption Modulators SO IEEE MICROWAVE AND WIRELESS COMPONENTS LETTERS LA English DT Article DE Electro-absorption modulators (EAMs); microwave photonics; self-interference cancellation (SIC) AB An optical analog self-interference cancellation system for radio-frequency communications is proposed and experimentally demonstrated. The system uses two electro-absorption modulators, an optical attenuator and delay, and a balanced photodetector to subtract strong self-interference from a corrupted received signal and recover a weak signal of interest. The system achieves > 65 dB narrowband cancellation and > 30 dB broadband cancellation across more than 40 MHz bandwidth for interference in both the 900 MHz and 2.4GHz bands. Both narrowband and broadband cancellation are frequency tunable, and can be combined with other forms of interference cancellation to achieve even higher levels of cancellation. C1 [Chang, Matthew P.; Prucnal, Paul R.] Princeton Univ, Dept Elect Engn, Princeton, NJ 08544 USA. [Fok, Mable] Univ Georgia, Coll Engn, Athens, GA 30602 USA. [Hofmaier, Andrew] USA, CERDEC, Aberdeen Proving Ground, MD 21005 USA. RP Chang, MP (reprint author), Princeton Univ, Dept Elect Engn, Princeton, NJ 08544 USA. EM mpchang@princeton.edu; mfok@uga.edu; andrew.p.hofmaier.civ@mail.mil FU National Security Agency FX This work was supported in part by the National Security Agency. NR 9 TC 19 Z9 19 U1 0 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1531-1309 J9 IEEE MICROW WIREL CO JI IEEE Microw. Wirel. Compon. Lett. PD FEB PY 2013 VL 23 IS 2 BP 99 EP 101 DI 10.1109/LMWC.2013.2240288 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA 138IE UT WOS:000318501400015 ER PT J AU Lee, BB Baumgartner, I Berlien, HP Bianchini, G Burrows, P Do, YS Ivancev, K Kool, LS Laredo, J Loose, DA Lopez-Gutierrez, JC Mattassi, R Parsi, K Rimon, U Rosenblatt, M Shortell, C Simkin, R Stillo, F Villavicencio, L Yakes, W AF Lee, B. B. Baumgartner, I. Berlien, H. P. Bianchini, G. Burrows, P. Do, Y. S. Ivancev, K. Kool, L. S. Laredo, J. Loose, D. A. Lopez-Gutierrez, J. C. Mattassi, R. Parsi, K. Rimon, U. Rosenblatt, M. Shortell, C. Simkin, R. Stillo, F. Villavicencio, L. Yakes, W. TI Consensus Document of the International Union of Angiology (IUA)-2013 Current concepts on the management of arterio-venous malformations SO INTERNATIONAL ANGIOLOGY LA English DT Article DE Arteriovenous malformations; Central nervous system vascular malformations; Classffication; Angiography; Sclerotherapy ID CONGENITAL VASCULAR MALFORMATIONS; HEREDITARY HEMORRHAGIC TELANGIECTASIA; N-BUTYL CYANOACRYLATE; PULMONARY ARTERIAL-PRESSURE; SINGLE-CENTER EXPERIENCE; BLOOD-POOL SCINTIGRAPHY; FOLLOW-UP ASSESSMENT; PORT-WINE STAINS; VENOUS MALFORMATIONS; SOFT-TISSUE AB Arterio-venous malformations (AVMs) are congenital vascular malformations (CVMs) that result from birth defects involving the vessels of both arterial and venous origins, resulting in direct communications between the different size vessels or a meshwork of primitive reticular networks of dysplastic minute vessels which have failed to mature to become 'capillary' vessels termed "nidus". These lesions are defined by shunting of high velocity, low resistance flow from the arterial vasculature into the venous system in a variety of fistulous conditions. A systematic classification system developed by various groups of experts (Hamburg classification, ISSVA classification, Schobinger classification, angiographic classification of AVMs,) has resulted in a better understanding of the biology and natural history of these lesions and improved management of CVMs and AVMs. The Hamburg classification, based on the embryological differentiation between extratruncular and truncular type of lesions, allows the determination of the potential of progression and recurrence of these lesions. The majority of all AVMs are extra-truncular lesions with persistent proliferative potential, whereas truncular AVM lesions are exceedingly rare. Regardless of the type, AV shunting may ultimately result in significant anatomical, pathophysiological and hemodynamic consequences. Therefore, despite their relative rarity (10-20% of all CVMs), AVMs remain the most challenging and potentially limb or life-threatening form of vascular anomalies. The initial diagnosis and assessment may be facilitated by non- to minimally invasive investigations such as duplex ultrasound, magnetic resonance imaging (MRI), MR angiography (MRA), computerized tomography (CT) and CT angiography (CTA). Arteriography remains the diagnostic gold standard, and is required for planning subsequent treatment. A multidisciplinary team approach should be utilized to integrate surgical and non-surgical interventions for optimum care. Currently available treatments are associated with significant risk of complications and morbidity. However, an early aggressive approach to elimiate the nidus (if present) may be undertaken if the benefits exceed the risks. Trans-arterial coil embolization or ligation of feeding arteries where the nidus is left intact, are incorrect approaches and may result in proliferation of the lesion. Furthermore, such procedures would prevent future endovascular access to the lesions via the arterial route. Surgically inaccessible, infiltrating, extra-truncular AVMs can be treated with endovascular therapy as an independent modality. Among various embolo-sclerotherapy agents, ethanol sclerotherapy produces the best long term outcomes with minimum recurrence. However, this procedure requires extensive training and sufficient experience to minimize complications and associated morbidity For the surgically accessible lesions, surgical resection may be the treatment of choice with a chance of optimal control. Preoperative sclerotherapy or embolization may supplement the subsequent surgical excision by reducing the morbidity (e.g. operative bleeding) and defining the lesion borders. Such a combined approach may provide an excellent potential for a curative result. Conclusion. AVMs are high flow congenital vascular malformations that may occur in any part of the body. The clinical presentation depends on the extent and size of the lesion and can range from an asymptomatic birthmark to congestive heart failure. Detailed investigations including duplex ultrasound, MRI/MRA and CT/CTA are required to develop an appropriate treatment plan. Appropriate management is best achieved via a multi-disciplinary approach and interventions should be undertaken by appropriately trained physicians. [Int Angiol 2013;32:9-36] C1 [Lee, B. B.] George Washington Univ, Div Vasc Surg, Dept Surg, Ctr Vasc Malformat & Lymphedema,Sch Med, Washington, DC 20037 USA. [Baumgartner, I.] Univ Hosp Bern, Dept Internal Med Director Clin & Intervent Angio, Swiss Cardiovasc Ctr, CH-3010 Bern, Switzerland. [Berlien, H. P.] Evangel Elisabeth Klin, Dept Laser Med, Berlin, Germany. [Bianchini, G.] IDI Hosp, Div Vasc Surg, Ctr Vasc Anomalies, Rome, Italy. [Burrows, P.] Med Coll Wisconsin, Childrens Hosp Wisconsin, Dept Radiol, Milwaukee, WI 53226 USA. [Do, Y. S.] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Seoul, South Korea. [Do, Y. S.] Sungkyunkwan Univ, Sch Med, Seoul, South Korea. [Ivancev, K.] Royal Free Hosp, Dept Intervent Radiol, Complex EVAR Programme, London NW3 2QG, England. [Kool, L. S.] Radboud Univ Nijmegen, Dept Intervent Radiol, Med Ctr, NL-6525 ED Nijmegen, Netherlands. [Laredo, J.] George Washington Univ, Div Vasc Surg, Dept Surg, Ctr Vein Lymphat & Vasc Malformat,Sch Med, Washington, DC 20037 USA. [Loose, D. A.] Die Facharztklin Hamburg, Dept Vasc Surg, European Ctr Diag & Treatment Vasc Malformat, Hamburg, Germany. [Lopez-Gutierrez, J. C.] La Paz Children Hosp, Vasc Anomalies Ctr, Dept Surg, Madrid, Spain. [Mattassi, R.] Clin Inst Humanitas Mater Domini, Dept Vasc Surg, Ctr Vasc Malformat Stefan Belov, Castellanza, Varese, Italy. [Parsi, K.] Univ New S Wales, Dept Dermatol, St Vincents Hosp, Sydney, NSW, Australia. [Rimon, U.] Tel Aviv Univ, Sackler Sch Med, Dept Intervent Radiol, Sheba Med Ctr, IL-69978 Tel Aviv, Israel. [Rosenblatt, M.] Connecticut Image Guided Surg, Fairfield, CT USA. [Shortell, C.] Duke Univ, Med Ctr, Dept Surg, Div Vasc Surg, Durham, NC 27710 USA. [Shortell, C.] Duke Univ, Med Ctr, Dept Surg, Fac Affairs, Durham, NC 27710 USA. [Simkin, R.] Univ Buenos Aires, Fac Med, Dept Surg, Buenos Aires, DF, Argentina. [Stillo, F.] IDI Hosp, Dept Vasc Surg, Ctr Vasc Anomalies, Rome, Italy. [Villavicencio, L.] Uniformed Serv Univ Hlth Sci, Dept Surg, Sch Med, Walter Reed Army Med Ctr, Bethesda, MD USA. [Yakes, W.] Univ Colorado, Hlth Sci Ctr, Vasc Malformat Ctr, Englewood, CO USA. RP Lee, BB (reprint author), George Washington Univ, Div Vasc Surg, Dept Surg, Med Ctr, 22nd & 1 St,NW,6th Floor, Washington, DC 20037 USA. EM bblee@mfa.gwu.edu NR 228 TC 26 Z9 29 U1 0 U2 10 PU EDIZIONI MINERVA MEDICA PI TURIN PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY SN 0392-9590 J9 INT ANGIOL JI Int. Angiol. PD FEB PY 2013 VL 32 IS 1 BP 9 EP 36 PG 28 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 135CI UT WOS:000318263200002 PM 23435389 ER PT J AU Berry, JS Trappey, AF Vreeland, T Clifton, G Sears, A Clive, K Ferrise, S Saenger, JS Kirkpatrick, AD Lallemand, M Peoples, GE AF Berry, J. S. Trappey, A. F. Vreeland, T. Clifton, G. Sears, A. Clive, K. Ferrise, S. Saenger, J. S. Kirkpatrick, A. D. Lallemand, M. Peoples, G. E. TI Pure Flat Epithelial Atypia (PFEA): Excise or Observe SO ANNALS OF SURGICAL ONCOLOGY LA English DT Meeting Abstract CT 66th Annual Cancer Symposium of the Society-of-Surgical-Oncology (SSO) CY MAR 06-09, 2013 CL National Harbor, MD SP Soc Surg Oncol (SSO) C1 [Berry, J. S.; Trappey, A. F.; Vreeland, T.; Sears, A.; Clive, K.; Ferrise, S.; Saenger, J. S.; Kirkpatrick, A. D.; Peoples, G. E.] Brooke Army Med Ctr, San Antonio, TX USA. [Clifton, G.] Blanchfield Army Community Hosp, Ft Campbell, KY USA. [Lallemand, M.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD FEB PY 2013 VL 20 SU 1 BP S45 EP S46 PG 2 WC Oncology; Surgery SC Oncology; Surgery GA 133XR UT WOS:000318174700115 ER PT J AU Trappey, AF Berry, J Vreeland, T Hale, D Sears, A Dabney, RS Ponniah, S Perez, SA Clifton, GT Hintz, C Covelli, JD Papamichail, M Peoples, GE Mittendorf, EA AF Trappey, A. F. Berry, J. Vreeland, T. Hale, D. Sears, A. Dabney, R. S. Ponniah, S. Perez, S. A. Clifton, G. T. Hintz, C. Covelli, J. D. Papamichail, M. Peoples, G. E. Mittendorf, E. A. TI Factors Associated with Recurrence in Breast Cancer Patients Vaccinated with the HER2-Derived GP2 Vaccine SO ANNALS OF SURGICAL ONCOLOGY LA English DT Meeting Abstract CT 66th Annual Cancer Symposium of the Society-of-Surgical-Oncology (SSO) CY MAR 06-09, 2013 CL National Harbor, MD SP Soc Surg Oncol (SSO) C1 [Trappey, A. F.; Berry, J.; Vreeland, T.; Hale, D.; Sears, A.; Dabney, R. S.; Clifton, G. T.; Peoples, G. E.] Brooke Army Med Ctr, San Antonio, TX USA. [Ponniah, S.; Hintz, C.; Covelli, J. D.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Perez, S. A.; Papamichail, M.] St Savas Canc Hosp, Canc Immunol & Immunotherapy Ctr, Athens, Greece. [Mittendorf, E. A.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD FEB PY 2013 VL 20 SU 1 BP S59 EP S59 PG 1 WC Oncology; Surgery SC Oncology; Surgery GA 133XR UT WOS:000318174700155 ER PT J AU Vreeland, TJ Berry, JS Trappey, AF Hale, D Clifton, GT Sears, A Shumway, NM Holmes, JP Ponniah, S Mittendorf, EA Ioannides, CG Peoples, GE AF Vreeland, T. J. Berry, J. S. Trappey, A. F. Hale, D. Clifton, G. T. Sears, A. Shumway, N. M. Holmes, J. P. Ponniah, S. Mittendorf, E. A. Ioannides, C. G. Peoples, G. E. TI Use of an Attenuated Version of a Strongly Immunogenic, Peptide-based Vaccine to Enhance an Anti-cancer Immune Response against Folate Receptor-alpha (FR alpha) SO ANNALS OF SURGICAL ONCOLOGY LA English DT Meeting Abstract CT 66th Annual Cancer Symposium of the Society-of-Surgical-Oncology (SSO) CY MAR 06-09, 2013 CL National Harbor, MD SP Soc Surg Oncol (SSO) C1 [Vreeland, T. J.; Berry, J. S.; Trappey, A. F.; Hale, D.; Clifton, G. T.; Sears, A.; Shumway, N. M.; Peoples, G. E.] Brooke Army Med Ctr, San Antonio, TX USA. [Mittendorf, E. A.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Ponniah, S.; Ioannides, C. G.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Holmes, J. P.] USN, Dept Hematol & Med Oncol, San Diego Med Ctr, San Diego, CA 92152 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD FEB PY 2013 VL 20 SU 1 BP S59 EP S59 PG 1 WC Oncology; Surgery SC Oncology; Surgery GA 133XR UT WOS:000318174700156 ER PT J AU Niu, N Yang, FB Cheng, JRC Reddivari, S AF Niu, Nan Yang, Fangbo Cheng, Jing-Ru C. Reddivari, Sandeep TI Conflict resolution support for parallel software development SO IET SOFTWARE LA English DT Article ID CONFIGURATION MANAGEMENT AB Parallel changes, in which separate lines of development are carried out by different developments, are a basic fact of developing and maintaining large-scale software systems. Merging parallel versions and variants of source code is a common and essential software engineering activity. When a non-trivial number of conflicts is detected, there is a need to support the maintainer in investigating and resolving these conflicts. In this study, the authors present software conflict resolution recommender (scoreRec), a cost-benefit approach to ranking the conflicting software entities. The contributions of scoreRec lie in the leverage of both structural and semantic information of the source code to generate conflict resolution recommendations, as well as the hierarchical presentation of the recommendations with detailed explanations. The authors evaluate scoreRec through an industrial-strength legacy system developed by computational scientists. The results show that scoreRec offers relevant and insightful information and sound engineering support for conflict resolution. The authors' work also sheds light on the future development of recommendation systems in the context of software merging. C1 [Niu, Nan; Yang, Fangbo; Reddivari, Sandeep] Mississippi State Univ, Dept Comp Sci & Engn, Mississippi State, MS 39762 USA. [Cheng, Jing-Ru C.] USA, Informat Technol Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Niu, N (reprint author), Mississippi State Univ, Dept Comp Sci & Engn, POB 9637, Mississippi State, MS 39762 USA. EM niu@cse.msstate.edu FU US Army Engineer Research & Development Center [W912HZ-10-C-0101] FX The work is supported by the US Army Engineer Research & Development Center (Award W912HZ-10-C-0101). Any opinions, findings, and conclusions expressed herein are the authors' and do not necessarily reflect those of the sponsor. NR 33 TC 2 Z9 2 U1 0 U2 4 PU INST ENGINEERING TECHNOLOGY-IET PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 1751-8806 EI 1751-8814 J9 IET SOFTW JI IET Softw. PD FEB PY 2013 VL 7 IS 1 BP 1 EP 11 DI 10.1049/iet-sen.2012.0089 PG 11 WC Computer Science, Software Engineering SC Computer Science GA 134QZ UT WOS:000318230600001 ER PT J AU Linkov, I Bates, ME Trump, BD Seager, TP Chappell, MA Keisler, JM AF Linkov, Igor Bates, Matthew E. Trump, Benjamin D. Seager, Thomas P. Chappell, Mark A. Keisler, Jeffrey M. TI For nanotechnology decisions, use decision analysis SO NANO TODAY LA English DT Article DE Risk; Decision analysis; Health and safety; Green nano manufacturing ID NANOMATERIALS AB Management of nanotechnology is rife with complicated, contentious, and risky decisions. These decisions involve significant uncertainty, multiple stakeholder groups, competing objectives, and dynamic, non-linear interdependencies which test the limits of unaided human judgment. In the past, formal methods of risk analysis have been used to evaluate new technologies, but these methods ignore decision-relevant qualitative information and rely on a volume of quantitative engineering and scientific data that simply does not exist for many nanomaterials. Yet, we know that robust production decisions need to be holistic and based on all available information if we are to minimize negative externalities to society, human health, and the environment. We discuss how the use of decision analytical methods such as Multi-Criteria Decision Analysis and value of information analysis can help to fill existing gaps in nanomaterial risk management to make the best use of all available qualitative and quantitative information and prioritize future research based on expected decision relevance. This will help nanoparticle scientists and manufacturers to better develop and identify optimal materials and production methods in the midst of high uncertainty. Published by Elsevier Ltd. C1 [Linkov, Igor; Bates, Matthew E.; Chappell, Mark A.] USA, Corps Engineers, Engn Res & Dev Ctr, Concord, MA 01742 USA. [Trump, Benjamin D.] Univ Michigan, Hlth Management & Policy Program, Ann Arbor, MI 48109 USA. [Seager, Thomas P.] Arizona State Univ, Sch Sustainable Engn & Built Environm, Tempe, AZ 85287 USA. [Keisler, Jeffrey M.] Univ Massachusetts, Boston, MA 02125 USA. RP Linkov, I (reprint author), USA, Corps Engineers, Engn Res & Dev Ctr, Environm Lab, 696 Virginia Rd, Concord, MA 01742 USA. EM Igor.Linkov@usace.army.mil NR 24 TC 5 Z9 7 U1 3 U2 34 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1748-0132 J9 NANO TODAY JI Nano Today PD FEB PY 2013 VL 8 IS 1 BP 5 EP 10 DI 10.1016/j.nantod.2012.10.002 PG 6 WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 132EL UT WOS:000318050600004 ER PT J AU Shakarian, P Roos, P Moores, G AF Shakarian, Paulo Roos, Patrick Moores, Geoffrey TI A novel analytical method for evolutionary graph theory problems SO BIOSYSTEMS LA English DT Article DE Evolutionary dynamics; Moran process; Complex networks ID DYNAMICS; NETWORKS; GAME AB Evolutionary graph theory studies the evolutionary dynamics of populations structured on graphs. A central problem is determining the probability that a small number of mutants overtake a population. Currently, Monte Carlo simulations are used for estimating such fixation probabilities on general directed graphs, since no good analytical methods exist. In this paper, we introduce a novel deterministic framework for computing fixation probabilities for strongly connected, directed, weighted evolutionary graphs under neutral drift. We show how this framework can also be used to calculate the expected number of mutants at a given time step (even if we relax the assumption that the graph is strongly connected), how it can extend to other related models (e.g. voter model), how our framework can provide non-trivial bounds for fixation probability in the case of an advantageous mutant, and how it can be used to find a non-trivial lower bound on the mean time to fixation. We provide various experimental results determining fixation probabilities and expected number of mutants on different graphs. Among these, we show that our method consistently outperforms Monte Carlo simulations in speed by several orders of magnitude. Finally we show how our approach can provide insight into synaptic competition in neurology. Published by Elsevier Ireland Ltd. C1 [Shakarian, Paulo; Moores, Geoffrey] US Mil Acad, Network Sci Ctr, West Point, NY 10996 USA. [Shakarian, Paulo; Moores, Geoffrey] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. [Roos, Patrick] Univ Maryland, Dept Comp Sci, College Pk, MD 20740 USA. RP Shakarian, P (reprint author), US Mil Acad, Network Sci Ctr, West Point, NY 10996 USA. EM paulo@shakarian.net FU ARO [611102B74F, 2GDATXR042]; OSD [F1AF262025G01]; ONR [W911NF0810144] FX P.S. is supported by ARO projects 611102B74F and 2GDATXR042 as well as OSD project F1AF262025G01. P.R. is supported by ONR grant W911NF0810144. P.S. would like to thank Stephen Turney (Harvard University) for several discussions concerning his work. The opinions in this paper are those of the authors and do not necessarily reflect the opinions of the funders, the U.S. Military Academy, the U.S. Army, or the U.S. Navy. NR 27 TC 5 Z9 5 U1 0 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0303-2647 J9 BIOSYSTEMS JI Biosystems PD FEB PY 2013 VL 111 IS 2 BP 136 EP 144 DI 10.1016/j.biosystems.2013.01.006 PG 9 WC Biology; Mathematical & Computational Biology SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational Biology GA 121OP UT WOS:000317254400007 PM 23353025 ER PT J AU Smits, KM Sakaki, T Howington, SE Peters, JF Illangasekare, TH AF Smits, Kathleen M. Sakaki, Toshihiro Howington, Stacy E. Peters, John F. Illangasekare, Tissa H. TI Temperature Dependence of Thermal Properties of Sands across a Wide Range of Temperatures (30-70 degrees C) SO VADOSE ZONE JOURNAL LA English DT Article ID REDUCED AIR-PRESSURE; WATER-CONTENT; POROUS-MEDIA; CONDUCTIVITY MODEL; SOIL; HEAT; MOISTURE; DENSITY; ENHANCEMENT; DIFFUSIVITY AB Due to the dynamic nature of the shallow subsurface, knowledge of soil thermal properties across a wide range of soil moisture and temperature conditions is necessary to accurately describe heat transport in many settings. Soil thermal properties are difficult to measure at high temperatures, however, due to the lack of suitable measurement devices and the potential for measurement-induced changes. Therefore, thermal property data are often scarce and incomplete and very often limited to specific soils. Due to this scarcity of accurate experimental data, empirical relationships often do not accurately predict the thermal properties of soils as a function of both soil moisture and temperature. In this study, thermal conductivity and diffusivity were measured for silica sands under loose and tight packing conditions and a field sand under varied water saturation and temperature. Several recent sensor-based technologies were integrated into a small cell modified to have a network of sampling ports, continuously monitoring water saturation, temperature, and soil thermal properties. For the test sands studied, data showed that the thermal conductivity and diffusivity increased noticeably for sample temperatures >50 degrees C. At sample temperatures between 30 and 50 degrees C, any change in thermal properties with temperature was small. Thermal conductivities measured in this study were compared with independent estimates made using empirical models from the literature. In general, good agreement was observed for most thermal conductivity data when proper fitting parameters were established, except at intermediate saturation values. C1 [Smits, Kathleen M.; Sakaki, Toshihiro; Illangasekare, Tissa H.] Colorado Sch Mines, Ctr Expt Study Subsurface Environm Proc CESEP, Dep Civil & Environm Engn, Golden, CO 80401 USA. [Howington, Stacy E.; Peters, John F.] USA, Corps Engineers, Ctr Res & Dev, Vicksburg, MS 39180 USA. RP Smits, KM (reprint author), Colorado Sch Mines, Ctr Expt Study Subsurface Environm Proc CESEP, Dep Civil & Environm Engn, Golden, CO 80401 USA. EM ksmits@mines.edu RI Smits, Kathleen/F-8465-2014 NR 43 TC 18 Z9 18 U1 2 U2 21 PU SOIL SCI SOC AMER PI MADISON PA 677 SOUTH SEGOE ROAD, MADISON, WI 53711 USA SN 1539-1663 J9 VADOSE ZONE J JI Vadose Zone J. PD FEB PY 2013 VL 12 IS 1 DI 10.2136/vzj2012.0033 PG 8 WC Environmental Sciences; Soil Science; Water Resources SC Environmental Sciences & Ecology; Agriculture; Water Resources GA 127QK UT WOS:000317713300009 ER PT J AU Stevens, GD AF Stevens, Geoffrey D. TI Controlling Munitions Stockpiles: How to Stop the Inadvertent Arming of Insurgencies SO GLOBAL POLICY LA English DT Article C1 USA, Pacifics Asia Pacific Counter IED Fus Ctr, Ft Shafter, HI USA. RP Stevens, GD (reprint author), USA, Pacifics Asia Pacific Counter IED Fus Ctr, Ft Shafter, HI USA. NR 15 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1758-5880 J9 GLOB POLICY JI Glob. Policy PD FEB PY 2013 VL 4 IS 1 BP 118 EP 121 DI 10.1111/j.1758-5899.2012.00189.x PG 4 WC International Relations; Political Science SC International Relations; Government & Law GA 116WN UT WOS:000316914100018 ER PT J AU Holcomb, JB del Junco, DJ Fox, EE Wade, CE Cohen, MJ Schreiber, MA Alarcon, LH Bai, Y Brasel, KJ Bulger, EM Cotton, BA Matijevic, N Muskat, P Myers, JG Phelan, HA White, CE Zhang, JJ Rahbar, MH AF Holcomb, John B. del Junco, Deborah J. Fox, Erin E. Wade, Charles E. Cohen, Mitchell J. Schreiber, Martin A. Alarcon, Louis H. Bai, Yu Brasel, Karen J. Bulger, Eileen M. Cotton, Bryan A. Matijevic, Nena Muskat, Peter Myers, John G. Phelan, Herb A. White, Christopher E. Zhang, Jiajie Rahbar, Mohammad H. CA PROMMTT Study Grp TI The Prospective, Observational, Multicenter, Major Trauma Transfusion (PROMMTT) Study Comparative Effectiveness of a Time-Varying Treatment With Competing Risks SO JAMA SURGERY LA English DT Article ID DAMAGE CONTROL RESUSCITATION; FRESH-FROZEN PLASMA; RED-BLOOD-CELL; REQUIRING MASSIVE TRANSFUSION; LIFE-THREATENING HEMORRHAGE; IMPROVED SURVIVAL; HEMOSTATIC RESUSCITATION; EMERGENCY-DEPARTMENT; CONTROL LAPAROTOMY; COMBAT CASUALTIES AB Objective: To relate in-hospital mortality to early transfusion of plasma and/or platelets and to time-varying plasma: red blood cell (RBC) and platelet: RBC ratios. Design: Prospective cohort study documenting the timing of transfusions during active resuscitation and patient outcomes. Data were analyzed using time-dependent proportional hazards models. Setting: Ten US level I trauma centers. Patients: Adult trauma patients surviving for 30 minutes after admission who received a transfusion of at least 1 unit of RBCs within 6 hours of admission (n = 1245, the original study group) and at least 3 total units (of RBCs, plasma, or platelets) within 24 hours (n = 905, the analysis group). Main Outcome Measure: In-hospital mortality. Results: Plasma: RBC and platelet: RBC ratios were not constant during the first 24 hours (P < .001 for both). In a multivariable time-dependent Cox model, increased ratios of plasma: RBCs (adjusted hazard ratio = 0.31; 95% CI, 0.16-0.58) and platelets: RBCs (adjusted hazard ratio = 0.55; 95% CI, 0.31-0.98) were independently associated with decreased 6-hour mortality, when hemorrhagic death predominated. In the first 6 hours, patients with ratios less than 1: 2 were 3 to 4 times more likely to die than patients with ratios of 1: 1 or higher. After 24 hours, plasma and platelet ratios were unassociated with mortality, when competing risks from non-hemorrhagic causes prevailed. Conclusions: Higher plasma and platelet ratios early in resuscitation were associated with decreased mortality in patients who received transfusions of at least 3 units of blood products during the first 24 hours after admission. Among survivors at 24 hours, the subsequent risk of death by day 30 was not associated with plasma or platelet ratios. JAMA Surg. 2013; 148(2): 127-136. Published online October 15, 2012. doi:10.1001/2013.jamasurg.387 C1 [Holcomb, John B.; del Junco, Deborah J.; Wade, Charles E.; Cohen, Mitchell J.; Matijevic, Nena] Univ Texas Hlth Sci Ctr Houston, Dept Surg, Div Acute Care Surg, Ctr Translat Injury Res, Houston, TX 77030 USA. [Bai, Yu] Univ Texas Hlth Sci Ctr Houston, Dept Pathol & Lab Med, Houston, TX 77030 USA. [del Junco, Deborah J.; Fox, Erin E.; Rahbar, Mohammad H.] Univ Texas Hlth Sci Ctr Houston, Sch Med, Biostat Epidemiol Res Design Core, Ctr Clin & Translat Sci, Houston, TX 77030 USA. [Zhang, Jiajie] Univ Texas Hlth Sci Ctr Houston, Sch Biomed Informat, Houston, TX 77030 USA. [Rahbar, Mohammad H.] Univ Texas Hlth Sci Ctr Houston, Div Epidemiol Human Genet & Environm Sci, Sch Publ Hlth, Houston, TX 77030 USA. [Cohen, Mitchell J.] Univ Calif San Francisco, Sch Med, Dept Surg, Div Gen Surg, San Francisco, CA 94143 USA. [Schreiber, Martin A.] Oregon Hlth & Sci Univ, Div Trauma Crit Care & Acute Care Surg, Portland, OR 97201 USA. [Alarcon, Louis H.] Univ Pittsburgh, Sch Med, Dept Surg, Div Trauma & Gen Surg, Pittsburgh, PA USA. [Brasel, Karen J.] Med Coll Wisconsin, Div Trauma & Crit Care, Milwaukee, WI 53226 USA. [Bulger, Eileen M.] Univ Washington, Sch Med, Dept Surg, Div Trauma & Crit Care, Seattle, WA 98195 USA. [Muskat, Peter] Univ Cincinnati, Coll Med, Dept Surg, Div Trauma Crit Care, Cincinnati, OH 45267 USA. [Myers, John G.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, Sch Med, Div Trauma, San Antonio, TX 78229 USA. [White, Christopher E.] Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, San Antonio, TX USA. [Phelan, Herb A.] Univ Texas SW Med Ctr Dallas, Dept Surg, Sch Med, Div Burn Trauma Crit Care, Dallas, TX USA. RP Holcomb, JB (reprint author), Univ Texas Hlth Sci Ctr Houston, Dept Surg, Div Acute Care Surg, Ctr Translat Injury Res, 6410 Fannin,Ste 1100, Houston, TX 77030 USA. EM john.holcomb@uth.tmc.edu FU Haemonetics Corp; KCI USA, Inc; Winkenwerder Co; US Army Medical Research and Materiel Command [W81XWH-08-C-0712]; Clinical and Translational Science Awards funds of grant from the National Institutes of Health [UL1 RR024148] FX Dr Holcomb has served on the board for Tenaxis, the Regional Advisory Council for Trauma, and the National Trauma Institute; has provided expert testimony for the Department of Justice; and has received grants funded by Haemonetics Corp and KCI USA, Inc and consultant fees from The Winkenwerder Co. Dr Wade has served on the science board for Resuscitation Products, Inc and the advisory board for AstraZeneca.; This work was supported by subcontract W81XWH-08-C-0712 from the US Army Medical Research and Materiel Command. Infrastructure for the Data Coordinating Center was supported by Clinical and Translational Science Awards funds of grant UL1 RR024148 from the National Institutes of Health. NR 69 TC 187 Z9 193 U1 1 U2 18 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 2168-6254 J9 JAMA SURG JI JAMA Surg. PD FEB PY 2013 VL 148 IS 2 BP 127 EP 136 DI 10.1001/2013.jamasurg.387 PG 10 WC Surgery SC Surgery GA 113PZ UT WOS:000316681300004 PM 23560283 ER PT J AU Pathak, CS AF Pathak, Chandra S. TI Special Issue on Radar Rainfall Data Analyses and Applications SO JOURNAL OF HYDROLOGIC ENGINEERING LA English DT Editorial Material C1 USA, Corps Engineers, Washington, DC 20314 USA. RP Pathak, CS (reprint author), USA, Corps Engineers, Washington, DC 20314 USA. EM chandra.s.pathak@usace.army.mil NR 0 TC 1 Z9 1 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1084-0699 J9 J HYDROL ENG JI J. Hydrol. Eng. PD FEB PY 2013 VL 18 IS 2 SI SI BP 131 EP 132 DI 10.1061/(ASCE)HE.1943-5584.0000738 PG 2 WC Engineering, Civil; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA 111ZK UT WOS:000316560700001 ER PT J AU Anagnostou, EN Pathak, CS Morales, CA AF Anagnostou, Emmanouil N. Pathak, Chandra S. Morales, Carlos A. TI Use of Storm Life Cycle Information and Lightning Data in Radar-Rainfall Estimation SO JOURNAL OF HYDROLOGIC ENGINEERING LA English DT Article DE Radar rainfall; Rain gauge; Bias; Lightning; Storm tracking ID CONVECTIVE SYSTEMS; UNITED-STATES; GAUGE DATA; PRECIPITATION; CLOUD; BIAS; CALIBRATION; ERROR AB Correcting real-time radar-rainfall estimates for mean field systematic errors (bias) is normally accomplished through gauge-based adjustment procedures. This study explores two auxiliary data sources derived from cloud-to-ground (CG) lightning measurements and storm tracking applied on radar images in terms of providing microphysical information useful for improving the efficiency of gauge-based bias adjustment techniques. The CG information is used to classify storms into thunderstorms (T-storms) versus showers (i.e., storms without lightning) and the tracking algorithm is used to classify storms according to their stage of maturity (i.e., growing, maturing, and decaying). Data for this study are based on high-resolution radar-rainfall estimates (2-km spatial grid resolution at 15-min intervals) available over the South Florida Water Management District for a period of 11 months, along with corresponding rain gauge measurements from 120 gauges and CG occurrences from the National Lightning Detection Network. The radar error analysis for T-storms versus showers and for the different storm maturity stages indicate that storm tracking and CG contain significant microphysical information that can improve radar-rainfall estimation. It is shown that radar rain estimates tend to underestimate convective rainfall, primarily associated with the growing stage of the storms or the occurrences of CG lightning; showers and storms at mature or decay stages are shown to be better represented by the standard reflectivity-rainfall (Z-R) relationship used for convective and tropical storms in Florida. Results from this study indicate that information regarding storm maturity stage derived from tracking radar images, and to a lesser extent, CG observations, can be used to reduce variability in the Z-R conversion and consequently improve accuracy in real-time radar-rainfall estimation. DOI: 10.1061/(ASCE)HE.1943-5584.0000557. (C) 2013 American Society of Civil Engineers. C1 [Anagnostou, Emmanouil N.] Univ Connecticut, Dept Civil & Environm Engn, Storrs, CT 06269 USA. [Pathak, Chandra S.] USA, Corps Engineers, Washington, DC 20314 USA. [Pathak, Chandra S.] South Florida Water Management Dist, W Palm Beach, FL USA. [Morales, Carlos A.] Univ Sao Paulo, Dept Atmospher Sci, Sao Paulo, Brazil. RP Anagnostou, EN (reprint author), Univ Connecticut, Dept Civil & Environm Engn, Storrs, CT 06269 USA. EM manos@engr.uconn.edu FU South Florida Water Management District FX This study was supported by the South Florida Water Management District. Radar and rain gauge rainfall data were provided by the district. The NLDN lightning data were acquired from NASA's Global Hydrology and Climate Center. NR 25 TC 1 Z9 1 U1 1 U2 5 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1084-0699 J9 J HYDROL ENG JI J. Hydrol. Eng. PD FEB PY 2013 VL 18 IS 2 SI SI BP 168 EP 174 DI 10.1061/(ASCE)HE.1943-5584.0000557 PG 7 WC Engineering, Civil; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA 111ZK UT WOS:000316560700005 ER PT J AU Malusis, MA McKeehan, MD AF Malusis, Michael A. McKeehan, Matthew D. TI Chemical Compatibility of Model Soil-Bentonite Backfill Containing Multiswellable Bentonite SO JOURNAL OF GEOTECHNICAL AND GEOENVIRONMENTAL ENGINEERING LA English DT Article DE Backfill; Bentonite; Chemical Compatibility; Cutoff wall; Hydraulic Conductivity; Vertical barrier ID CALCIUM-CHLORIDE SOLUTIONS; GEOSYNTHETIC CLAY LINERS; HYDRAULIC CONDUCTIVITY; BREAKTHROUGH CURVES; SALT-SOLUTIONS; COMPRESSIBILITY; PERFORMANCE AB The objective of this study was to evaluate the chemical compatibility of model soil-bentonite backfills containing multiswellable bentonite (MSB) relative to that of similar backfills containing untreated sodium (Na) bentonite or a commercially available, contaminant-resistant bentonite (SW101). Flexible-wall tests were conducted on consolidated backfill specimens (effective stress = 34.5 kPa) containing clean sand and 4.5-5.7% bentonite (by dry weight) using tap water and calcium chloride (CaCl2) solutions (10-1,000 mM) as the permeant liquids. Final values of hydraulic conductivity (k) and intrinsic permeability (K) to the CaCl2 solutions were determined after achieving both short-term termination criteria as defined by ASTM D5084 and long-term termination criteria for chemical equilibrium between the influent and effluent. Specimens containing MSB exhibited the smallest increases in k and K upon permeation with a given CaCl2 solution relative to specimens containing untreated Na bentonite or SW101. However, none of the specimens exhibited more than a fivefold increase in k or K, regardless of CaCl2 concentration or bentonite type. Final k values for specimens permeated with a given CaCl2 solution after permeation with tap water were similar to those for specimens of the same backfill permeated with only the CaCl2 solution, indicating that the order of permeation had no significant effect on k. Also, final k values for all specimens were within a factor of two of the k measured after achieving the ASTM D5084 termination criteria. Thus, use of only the ASTM D5084 criteria would have been sufficient to obtain reasonable estimates of long-term hydraulic conductivity for the specimens in this study. DOI: 10.1061/(ASCE)GT.1943-5606.0000729. (C) 2013 American Society of Civil Engineers. C1 [Malusis, Michael A.; McKeehan, Matthew D.] Bucknell Univ, Dept Civil & Environm Engn, Lewisburg, PA 17837 USA. [McKeehan, Matthew D.] USA, Corps Engineers, Ft Carson, CO 80913 USA. RP Malusis, MA (reprint author), Bucknell Univ, Dept Civil & Environm Engn, Lewisburg, PA 17837 USA. EM michael.malusis@bucknell.edu NR 39 TC 12 Z9 13 U1 1 U2 9 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1090-0241 J9 J GEOTECH GEOENVIRON JI J. Geotech. Geoenviron. Eng. PD FEB PY 2013 VL 139 IS 2 BP 189 EP 198 DI 10.1061/(ASCE)GT.1943-5606.0000729 PG 10 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 111XX UT WOS:000316556400001 ER PT J AU Bianchini, A AF Bianchini, Alessandra TI Evaluation of Temperature-Induced Curling in Concrete Slabs Using Deflection Difference Analysis SO JOURNAL OF TRANSPORTATION ENGINEERING-ASCE LA English DT Article DE Heavy-weight deflectometer; Deflection; Slab curling; Impulse stiffness modulus ID PAVEMENTS AB The curling and warping of rigid pavements are the results of temperature and moisture gradients varying with depth, creep, and other factors, including construction. The indicators commonly used to evaluate slab deformation include a combination of deflections derived from a heavy-weight deflectometer (HWD) that are measured at specific locations on pavement slabs. Indicators comprise the sum of deflections (SD) across the joints and the impulse stiffness modulus (ISM) deflection ratio. The objective of this study was to identify the best indicator that can be employed for assessing the slab curling level relationship to temperature. The study was included in a project developed by the U.S. Army Engineer Research and Development Center (ERDC) and sponsored by the Federal Aviation Administration (FAA). At selected military bases, HWD testing on concrete slabs was executed on two different occasions toward the end of summer and in winter. These tests were conducted to monitor slab deflections under different temperature conditions to quantify a correlation between measured deflections and temperature. The analysis showed that the SD rather than the ISM ratio could be adopted as an indicator to determine the relative degree of slab curling. The proposed approach to analyze deflection parameters showed promising results, and with a dedicated database and intensive testing, it is believed possible to refine the regression analysis and increase its level of determination. The proposed methodology for analyzing SD and temperature differences can be adopted in those cases intended to evaluate curling trend relationships to construction or curing techniques. DOI:10.1061/(ASCE)TE.1943-5436.0000490. (C) 2013 American Society of Civil Engineers. C1 USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Bianchini, A (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM alessandra.bianchini@usace.army.mil FU Airport Technology Research and Development Branch of the Federal Aviation Administration FX The work described in this paper was supported by the Airport Technology Research and Development Branch of the Federal Aviation Administration managed by Dr. Satish K. Agrawal. The contents of the paper reflect the views of the author, who is responsible for the facts and accuracy of the data presented. The contents do not necessarily reflect the official views and policies of the Federal Aviation Administration or the U.S. Army Engineer Research and Development Center. The paper does not constitute a standard, specification, or regulation. Permission to publish was granted by the Director of the Geotechnical and Structures Laboratory. NR 18 TC 0 Z9 1 U1 1 U2 9 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-947X J9 J TRANSP ENG-ASCE JI J. Transp. Eng.-ASCE PD FEB PY 2013 VL 139 IS 2 BP 130 EP 137 DI 10.1061/(ASCE)TE.1943-5436.0000490 PG 8 WC Engineering, Civil; Transportation Science & Technology SC Engineering; Transportation GA 110XE UT WOS:000316480000003 ER PT J AU Masini, BD Owens, BD AF Masini, Brendan D. Owens, Brett D. TI Current Recommendations for Anterior Cruciate Ligament Bracing: When to Use SO PHYSICIAN AND SPORTSMEDICINE LA English DT Article DE anterior cruciate ligament; prophylactic bracing; postoperative bracing; functional bracing ID FUNCTIONAL KNEE BRACE; RECONSTRUCTION; EXTENSION; FOOTBALL; INJURY AB Braces are often used during various stages of recovery from an anterior cruciate ligament tear despite there being sparse definitive research supporting their use. This article reviews the literature on brace use for patients with anterior cruciate ligament tears in order to provide a guide for clinicians. There is evidence to support immediate postoperative bracing, with the goals of maintaining full extension and decreasing effusion. There may be a psychological benefit for its use in return to sport; however, this should be weighed against decreased performance. In the context of modern graft-fixation techniques and early mobilization protocols, empiric functional brace prescription is not required for successful long-term clinical outcomes and return to sport. C1 [Masini, Brendan D.; Owens, Brett D.] Keller Army Community Hosp, West Point, NY 10996 USA. RP Masini, BD (reprint author), Keller Army Community Hosp, 900 Washington Rd, West Point, NY 10996 USA. EM brendan.masini@amedd.army.mil NR 25 TC 0 Z9 0 U1 2 U2 22 PU JTE MULTIMEDIA PI BERWYN PA 1235 WESTLAKES DR, STE 220, BERWYN, PA 19312 USA SN 0091-3847 J9 PHYSICIAN SPORTSMED JI Physician Sportsmed. PD FEB PY 2013 VL 41 IS 1 BP 35 EP 39 DI 10.3810/psm.2013.02.1997 PG 5 WC Primary Health Care; Orthopedics; Sport Sciences SC General & Internal Medicine; Orthopedics; Sport Sciences GA 107ES UT WOS:000316198200004 PM 23445858 ER PT J AU Britt, TW Adler, AB Bliese, PD Moore, D AF Britt, Thomas W. Adler, Amy B. Bliese, Paul D. Moore, DeWayne TI Morale as a Moderator of the Combat Exposure-PTSD Symptom Relationship SO JOURNAL OF TRAUMATIC STRESS LA English DT Article ID PERCEIVED ORGANIZATIONAL SUPPORT; POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; IRAQ; INVOLVEMENT; CONSEQUENCES; PERSONALITY; AFGHANISTAN; DEPRESSION; PSYCHOLOGY AB We examined morale as a moderator of the relationship between combat exposure and posttraumatic stress disorder (PTSD) symptoms in a longitudinal study of U. S. soldiers who had participated in a deployment to Iraq. Soldiers (N = 636) completed assessments at 4 (Time 1) and 10 (Time 2) months following their combat deployment. Combat exposure (both breadth and perceived stressfulness), morale, and PTSD symptoms were assessed at Time 1, and PTSD symptoms were assessed again at Time 2. Results of multivariate multiple regressions revealed that morale at Time 1 interacted with both the breadth and stressfulness of combat exposure to predict PTSD symptoms at both Time 1 and Time 2, even when partialling out the effect of unit support. The slope of the given combat exposure and PTSD symptoms relationship was weaker when reports of morale were higher (with the effect size of the interaction ranging from .01 to .04). The results suggest that morale may buffer soldiers from the negative consequences of combat stressors. C1 [Britt, Thomas W.; Bliese, Paul D.] Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD USA. [Britt, Thomas W.; Adler, Amy B.] Walter Reed Army Inst Res, US Army Med Res Unit Europe, Heidelberg, Germany. [Britt, Thomas W.; Moore, DeWayne] Clemson Univ, Clemson, SC 29634 USA. RP Britt, TW (reprint author), Clemson Univ, Dept Psychol, Clemson, SC 29634 USA. EM twbritt@clemson.edu NR 44 TC 11 Z9 13 U1 1 U2 16 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0894-9867 J9 J TRAUMA STRESS JI J. Trauma Stress PD FEB PY 2013 VL 26 IS 1 BP 94 EP 101 DI 10.1002/jts.21775 PG 8 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 092CH UT WOS:000315095900012 PM 23371305 ER PT J AU Kerubo, LO Midiwo, JO Derese, S Langat, MK Akala, HM Waters, NC Peter, M Heydenreich, M AF Kerubo, Leonidah Omosa Midiwo, Jacob Ogweno Derese, Solomon Langat, Moses K. Akala, Hosea M. Waters, Norman C. Peter, Martin Heydenreich, Matthias TI Antiplasmodial Activity of Compounds from the Surface Exudates of Senecio roseiflorus SO NATURAL PRODUCT COMMUNICATIONS LA English DT Article DE Senecio roseiflorus; Asteraceae; Surface exudates; Antiplasmodial activity ID FLAVONOIDS; VISCOSA; GROWTH AB From the surface exudates of Senecio roseiflorus fourteen known methylated flavonoids and one phenol were isolated and characterized. The structures of these compounds were determined on the basis of their spectroscopic analysis. The surface exudate and the flavonoids isolated showed moderate to good antiplasmodial activity with 5,4'-dihydroxy-7-dimethoxyflavanone having the highest activity against chloroquine-sensitive (D6) and resistant (W2) strains of Plasmodium falciparum, with IC50 values of 3.2 +/- 0.8 and 4.4 +/- 0.01 mu g/mL respectively. C1 [Kerubo, Leonidah Omosa; Midiwo, Jacob Ogweno; Derese, Solomon] Univ Nairobi, Dept Chem, Nairobi, Kenya. [Langat, Moses K.] Univ Surrey, FEPS, Dept Chem, Guildford GU2 7XH, Surrey, England. [Akala, Hosea M.; Waters, Norman C.] USA, Med Res Unit Kenya, Walter Reed Project, APO, AE 09831 USA. [Peter, Martin; Heydenreich, Matthias] Univ Potsdam, Inst Chem, D-14415 Potsdam, Germany. RP Langat, MK (reprint author), Univ Surrey, FEPS, Dept Chem, Guildford GU2 7XH, Surrey, England. EM m.langat@surrey.ac.uk RI Derese, Solomon/H-5957-2016; OI Derese, Solomon/0000-0002-2640-3583; Heydenreich, Matthias/0000-0003-1639-4959 FU German Academic Exchange Service (DAAD); Deutsche Forschungsgemeinschaft, Germany [Pe 264/ 14-5]; Bundesministerium fur Zusammenarbeit [Pe-254/14-6] FX The authors are grateful to Mr Simon Mathenge for collection and identification of the plant material. LKO would like to thank sincerely the German Academic Exchange Service (DAAD) for a PhD scholarship. A grant for this research was also provided by the Deutsche Forschungsgemeinschaft, Germany, Grant No. Pe 264/ 14-5 and by the Bundesministerium fur Zusammenarbeit, Grant No. Pe-254/14-6. NR 17 TC 1 Z9 2 U1 0 U2 4 PU NATURAL PRODUCTS INC PI WESTERVILLE PA 7963 ANDERSON PARK LN, WESTERVILLE, OH 43081 USA SN 1934-578X J9 NAT PROD COMMUN JI Nat. Prod. Commun. PD FEB PY 2013 VL 8 IS 2 BP 175 EP 176 PG 2 WC Chemistry, Medicinal; Food Science & Technology SC Pharmacology & Pharmacy; Food Science & Technology GA 095XT UT WOS:000315369000010 PM 23513721 ER PT J AU Walker, JA Rossini, G Thompson, ME Wenke, JC Baer, DG AF Walker, John A. Rossini, Gianni Thompson, Michelle E. Wenke, Joseph C. Baer, David G. TI Effect of Proteasome Inhibitor 1 on Wound Healing: A Potential Scar Prevention Therapy SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE LA English DT Article ID GROWTH-FACTOR-BETA; MATRIX METALLOPROTEINASES; HYPERTROPHIC SCARS; FIBROSIS; SKIN; FETAL; FIBROBLASTS; EXPRESSION; COLLAGEN; REPAIR AB In vitro and in vivo assessments suggest that proteasome inhibitors may be useful for modulating wound healing. Methods. Proteasome Inhibitor I was used to assess the potential utility of proteasome inhibitors in improving wound healing in a standard rat model. Bilateral, 6 cm incisions were made 1 cm lateral to the spine of adult male Sprague Dawley rats. Animals were randomly assigned to 1 of 3 groups: no treatment (n = 15), low concentration (1% w/v, n = 15), or high concentration (5% w/v, n = 15). Treatments were applied to the left side incision at 0 hours, 24 hours, and 48 hours. Right-side incisions received a vehicle, dimethyl sulfoxide, alone and independent of the assigned group, serving as both external and internal controls. Rats were sacrificed at days 7, 14, and 28 (n = 5 per group) and wounds subjected to mechanical testing and histology. Results. No significant intergroup difference existed at 7 and 14 days. On day 28, a dose-dependent increase in tensile strength with increasing Proteasome Inhibitor I was, observed. Conclusion. Results suggest dimethyl sulfoxide was not the ideal vehicle and additional improvement may be realized by optimizing the delivery method. C1 [Walker, John A.] Univ Texas Hlth Sci Ctr San Antonio, Sch Med, Dept Radiol, San Antonio, TX 78229 USA. [Rossini, Gianni] SW Res Inst, Dept Biochem & Biomat, San Antonio, TX USA. [Thompson, Michelle E.] Tri Serv Res Lab, Dept Pathol, San Antonio, TX USA. [Wenke, Joseph C.; Baer, David G.] USA, Inst Surg Res, Regenerat Med Task Area, San Antonio, TX USA. RP Walker, JA (reprint author), 7703 Floyd Curl Dr,MS 7800, San Antonio, TX 78229 USA. EM walkerja@livemail.uthscsa.edu FU United States Department of Defense funds (USAMRMC) [W81XWH-07-1-0717] FX This study has been conducted in compliance with the Animal Welfare Act, the implementing Animal Welfare Regulations, and the principles of the Guide for the Care and Use of Laboratory Animals. This study was supported in part by the United States Department of Defense funds (USAMRMC # W81XWH-07-1-0717). NR 26 TC 0 Z9 0 U1 0 U2 1 PU H M P COMMUNICATIONS PI MALVERN PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA SN 1044-7946 J9 WOUNDS JI Wounds-Compend. Clin. Res. Pract. PD FEB PY 2013 VL 25 IS 2 BP 28 EP 33 PG 6 WC Dermatology; Surgery SC Dermatology; Surgery GA 096UM UT WOS:000315430100003 PM 25867804 ER PT J AU Allison, PG Chandler, MQ Rodriguez, RI Williams, BA Moser, RD Weiss, CA Poda, AR Lafferty, BJ Kennedy, AJ Seiter, JM Hodo, WD Cook, RF AF Allison, P. G. Chandler, M. Q. Rodriguez, R. I. Williams, B. A. Moser, R. D. Weiss, C. A., Jr. Poda, A. R. Lafferty, B. J. Kennedy, A. J. Seiter, J. M. Hodo, W. D. Cook, R. F. TI Mechanical properties and structure of the biological multilayered material system, Atractosteus spatula scales SO ACTA BIOMATERIALIA LA English DT Article DE Atractosteus spatula; Scale; Indentation; Structure; Mechanical properties ID DESIGN; NACRE; LEPISOSTEUS; FRACTURE; MOTHER; PEARL; ARMOR AB During recent decades, research on biological systems such as abalone shell and fish armor has revealed that these biological systems employ carefully arranged hierarchical multilayered structures to achieve properties of high strength, high ductility and light weight. Knowledge of such structures may enable pathways to design bio-inspired materials for various applications. This study was conducted to investigate the spatial distribution of structure, chemical composition and mechanical properties in mineralized fish scales of the species Atractosteus spatula. Microindentation tests were conducted, and cracking patterns and damage sites in the scales were examined to investigate the underlying protective mechanisms of fish scales under impact and penetration loads. A difference in nanomechanical properties was observed, with a thinner, stiffer and harder outer layer (indentation modulus similar to 69 GPa and hardness similar to 3.3 GPa) on a more compliant and thicker inner layer (indentation modulus similar to 14.3 GPa and hardness similar to 0.5 GPa). High-resolution scanning electron microscopy imaging of a fracture surface revealed that the outer layer contained oriented nanorods embedded in a matrix, and that the nanostructure of the inner layer contained fiber-like structures organized in a complex layered pattern. Damage patterns formed during microindentation show complex deformation mechanisms. Images of cracks identify growth through the outer layer, then deflection along the interface before growing and arresting in the inner layer. High-magnification images of the crack tip in the inner layer show void-linking and fiber-bridging exhibiting inelastic behavior. The observed difference in mechanical properties and unique nanostructures of different layers may have contributed to the resistance of fish scales to failure by impact and penetration loading. Published by Elsevier Ltd. on behalf of Acta Materialia Inc. C1 [Allison, P. G.; Chandler, M. Q.; Williams, B. A.; Moser, R. D.; Weiss, C. A., Jr.; Hodo, W. D.] USA, Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. [Rodriguez, R. I.] Univ Puerto Rico, Dept Mech Engn, Mayaguez, PR 00681 USA. [Poda, A. R.; Lafferty, B. J.; Kennedy, A. J.; Seiter, J. M.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Cook, R. F.] NIST, Div Ceram, Gaithersburg, MD 20899 USA. RP Allison, PG (reprint author), USA, Engineer Res & Dev Ctr, Geotech & Struct Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Paul.G.Allison@usace.army.mil RI Poda, Aimee/K-1905-2012; OI Allison, Paul/0000-0002-9041-237X FU US Army ERDC Military Engineering 6.1 Basic Research Program; ERDC Center for Directed Research Program FX The authors acknowledge the financial support for this work provided by the US Army ERDC Military Engineering 6.1 Basic Research Program and the ERDC Center for Directed Research Program. Discussions about this research with Drs. Mark Horstemeyer (MSU), Hongjoo Rhee (MSU), Christine Ortiz (MIT), Mark Myers (UCSD) and many others are gratefully acknowledged. The authors thank the staff and facilities of the ERDC Geotechnical and Structural Laboratory's Concrete and Materials Branch for supporting the experimental work. Permission to publish was granted by the Director, Geotechnical and Structures Laboratory, US Army Engineer Research and Development Center. NR 25 TC 12 Z9 13 U1 3 U2 62 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1742-7061 EI 1878-7568 J9 ACTA BIOMATER JI Acta Biomater. PD FEB PY 2013 VL 9 IS 2 BP 5289 EP 5296 DI 10.1016/j.actbio.2012.11.005 PG 8 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA 093DB UT WOS:000315170800037 PM 23149253 ER PT J AU Westbrook, CJ Veatch, W Morrison, A AF Westbrook, Cherie J. Veatch, William Morrison, Alasdair TI Ecohydrology Bearings - Invited Commentary Is ecohydrology missing much of the zoo? SO ECOHYDROLOGY LA English DT Article ID WATER-CONTROLLED ECOSYSTEMS; LANDFILL COVERS; NATIONAL-PARK; PRAIRIE DOG; PLANT; HERBIVORY; EROSION; ORGANISMS; ENGINEERS; HYDROLOGY AB Ecohydrology is now recognized as an interdisciplinary field, and as it grows, there needs to be greater awareness and dialogue on its focus and future direction. To take a bearings' on where we are, 339 ecohydrological articles published between January 2000 and December 2011 in two databases were surveyed. We found that 72% of the studies address questions at the interface of plant ecology and hydrology. The scarcity of studies of animals as drivers of hydrological patterns and processes led us to question the reasons behind plant-based ecologists embracing the term ecohydrology to a greater extent than animal-based ecologists. Following that discussion are current examples of synergies between animal ecologists and hydrologists that have led to a greater understanding of ecosystem processes and a way for ecohydrologists to factor in faunal interactions in their future research. We end by suggesting that ecohydrology form its own scientific society so it can more purposely advance knowledge and understanding of coupled ecological and hydrological system functions. Copyright (c) 2013 John Wiley & Sons, Ltd. C1 [Westbrook, Cherie J.; Morrison, Alasdair] Univ Saskatchewan, Ctr Hydrol, Saskatoon, SK S7N 5C8, Canada. [Westbrook, Cherie J.; Morrison, Alasdair] Univ Saskatchewan, Dept Geog & Planning, Saskatoon, SK S7N 5C8, Canada. [Veatch, William] USA, Corps Engineers, CEMVN ED H, New Orleans, LA USA. RP Westbrook, CJ (reprint author), Univ Saskatchewan, Ctr Hydrol, Saskatoon, SK S7N 5C8, Canada. EM cherie.westbrook@usask.ca FU Natural Science and Engineering Research Council of Canada (NSERC); Global Institute for Water Security FX The idea for this manuscript was inspired by separate discussions in graduate ecohydrology at the universities of Saskatchewan and Arizona. We thank David Eldridge and Paul Whitfield for insightful comments that challenged us and considerably strengthened the paper. The Natural Science and Engineering Research Council of Canada (NSERC) and the Global Institute for Water Security supported this research. NR 61 TC 3 Z9 3 U1 0 U2 39 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1936-0584 J9 ECOHYDROLOGY JI Ecohydrology PD FEB PY 2013 VL 6 IS 1 BP 1 EP 7 DI 10.1002/eco.1365 PG 7 WC Ecology; Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA 092HL UT WOS:000315110900002 ER PT J AU Rogers, CJ AF Rogers, Clifford J. TI Bloodied Banners: Martial Display on the Medieval Battlefield SO ENGLISH HISTORICAL REVIEW LA English DT Book Review C1 [Rogers, Clifford J.] US Mil Acad W Point, West Point, NY USA. RP Rogers, CJ (reprint author), US Mil Acad W Point, West Point, NY USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0013-8266 J9 ENGL HIST REV JI Engl. Hist. Rev. PD FEB PY 2013 VL 128 IS 530 BP 131 EP 133 DI 10.1093/ehr/ces350 PG 4 WC History SC History GA 089DV UT WOS:000314890500018 ER PT J AU Foster, N Guha, A Reitblatt, M Story, A Freedman, MJ Katta, NP Monsanto, C Reich, J Rexford, J Schlesinger, C Walker, D Harrison, MR AF Foster, Nate Guha, Arjun Reitblatt, Mark Story, Alec Freedman, Michael J. Katta, Naga Praveen Monsanto, Christopher Reich, Joshua Rexford, Jennifer Schlesinger, Cole Walker, David Harrison, Major Robert TI Languages for Software-Defined Networks SO IEEE COMMUNICATIONS MAGAZINE LA English DT Article AB Modern computer networks perform a bewildering array of tasks, from routing and traffic monitoring, to access control and server load balancing. However, managing these networks is unnecessarily complicated and error-prone, due to a heterogeneous mix of devices (e.g., routers, switches, firewalls, and middleboxes) with closed and proprietary configuration interfaces. Software-defined networks are poised to change this by offering a clean and open interface between networking devices and the software that controls them. In particular, many commercial switches support the OpenFlow protocol, and a number of campus, data center, and backbone networks have deployed the new technology. However, while SDNs make it possible to program the network, they does not make it easy. Today's OpenFlow controllers offer low-level APIs that mimic the underlying switch hardware. To reach SDNs' full potential, we need to identify the right higher-level abstractions for creating (and composing) applications. In the Frenetic project, we are designing simple and intuitive abstractions for programming the three main stages of network management: monitoring network traffic, specifying and composing packet forwarding policies, and updating policies in a consistent way. Overall, these abstractions make it dramatically easier for programmers to write and reason about SDN applications. C1 [Foster, Nate; Guha, Arjun; Reitblatt, Mark; Story, Alec] Cornell Univ, Ithaca, NY 14853 USA. [Freedman, Michael J.; Katta, Naga Praveen; Monsanto, Christopher; Reich, Joshua; Rexford, Jennifer; Schlesinger, Cole; Walker, David] Princeton Univ, Princeton, NJ 08544 USA. [Harrison, Major Robert] US Mil Acad, West Point, NY USA. RP Foster, N (reprint author), Cornell Univ, Ithaca, NY 14853 USA. EM princedpw@gmail.com FU ONR [N00014-09-1-0770, N00014-09-1-0652]; NSF [CNS-1111698, CNS-1111520]; TRUST FX Our work is supported in part by ONR grants N00014-09-1-0770 and N00014-09-1-0652, NSF grants CNS-1111698 and CNS-1111520, TRUST, and gifts from Dell, Intel, and Google. Any opinions, findings, and recommendations are those of the authors and do not necessarily reflect the views of the ONR or NSF. NR 17 TC 37 Z9 39 U1 6 U2 85 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0163-6804 EI 1558-1896 J9 IEEE COMMUN MAG JI IEEE Commun. Mag. PD FEB PY 2013 VL 51 IS 2 BP 128 EP 134 PG 7 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 092LF UT WOS:000315122400018 ER PT J AU Walsh, GF Dal Negro, L AF Walsh, Gary F. Dal Negro, Luca TI Engineering Plasmon-Enhanced Au Light Emission with Planar Arrays of Nanoparticles SO NANO LETTERS LA English DT Article DE Plasmonics; photoluminescence; optical sensor; efficiency; radiative engineering; plasmon decay ID SILVER NANOPARTICLES; GOLD NANORODS; NOBLE-METALS; SPECTROSCOPY; DIMERS; PHOTOLUMINESCENCE; RESONANCE; CELLS AB By systematically investigating the light emission and scattering properties of arrays of Au nanoparticles with varying size and separation, we demonstrate tunability and control of metal photoluminescence and unveil the critical role of near-field plasmonic coupling for the engineering of active metal nanostructures. We show that the decay of photoexcited electron-hole pairs into localized surface plasmons (LSPs) dramatically modifies the Au emission wavelength, line shape, and quantum efficiency depending both on particles size and separation. In particular, in arrays with near-field coupled nanoparticles we demonstrate broad light scattering and emission spectra that scale differently with respect to nanoparticle size due to the enhanced LSP nonradiative decay caused by near-field interparticle coupling. Our experimental results are fully supported by semianalytical extinction simulations based on rigorous coupled wave analysis, which demonstrate the importance of tuning plasmonic near-field coupling for the engineering of active devices based on light emitting arrays of metallic nanoparticles. C1 [Walsh, Gary F.; Dal Negro, Luca] Boston Univ, Dept Elect & Comp Engn, Boston, MA 02215 USA. [Walsh, Gary F.; Dal Negro, Luca] Boston Univ, Photon Ctr, Boston, MA 02215 USA. [Walsh, Gary F.] USA, NSRDEC, Nanomat Sci Team, Natick, MA 01760 USA. [Dal Negro, Luca] Boston Univ, Div Mat Sci & Engn, Brookline, MA 02446 USA. RP Dal Negro, L (reprint author), Boston Univ, Dept Elect & Comp Engn, 8 St Marys St, Boston, MA 02215 USA. EM dalnegro@bu.edu FU U.S. Army Natick Soldier Research, Development, and Engineering Center; SMART Scholarship Program. NSRDEC PAO [U12-550] FX This work was supported by the U.S. Army Natick Soldier Research, Development, and Engineering Center, and the SMART Scholarship Program. NSRDEC PAO# U12-550. All authors have given approval to the final version of the manuscript. NR 37 TC 26 Z9 27 U1 0 U2 113 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 EI 1530-6992 J9 NANO LETT JI Nano Lett. PD FEB PY 2013 VL 13 IS 2 BP 786 EP 792 DI 10.1021/nl304523v PG 7 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 091WC UT WOS:000315079500077 PM 23339774 ER PT J AU Wachs, JJ Wilson, GT AF Wachs, John J. Wilson, Gerald T. TI United States army tactical high-energy laser program SO OPTICAL ENGINEERING LA English DT Article DE high energy laser; deuterium fluoride laser; beam control; counter rocket AB The tactical high energy laser (THEL) program, conducted from 1996 to 2005, successfully demonstrated the capability of a high-energy laser to counter rockets, artillery, and mortars. The program was a US/Israeli cooperative research and development effort that was designated by the Secretary of Defense as an advanced concept technology demonstration with Presidential interest. The THEL system was designed and built under an SMDC/ARSTART prime contract awarded to TRW (now, Northrop Grumman Corporation), jointly managed by the Israel Ministry of Defence Directorate of Defence Research & Development. We summarize the effort and highlight some of the "firsts" of the THEL program. (c) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.OE.52.2.021009] C1 [Wachs, John J.] USA, Space & Missile Def Command, Army Forces Strateg Command USASMDC ARSTRAT, Ctr Tech,SMDC TC ED, Redstone Arsenal, AL 35898 USA. [Wilson, Gerald T.] SFAE MSLS CMDS SE, PEO M&S, Redstone Arsenal, AL 35898 USA. RP Wachs, JJ (reprint author), USA, Space & Missile Def Command, Army Forces Strateg Command USASMDC ARSTRAT, Ctr Tech,SMDC TC ED, Bldg 5220, Redstone Arsenal, AL 35898 USA. EM john.j.wachs.civ@mail.mil NR 2 TC 0 Z9 0 U1 1 U2 12 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 EI 1560-2303 J9 OPT ENG JI Opt. Eng. PD FEB PY 2013 VL 52 IS 2 AR 021009 DI 10.1117/1.OE.52.2.021009 PG 4 WC Optics SC Optics GA 092WX UT WOS:000315154800013 ER PT J AU Wolf, JM Cameron, KL Clifton, KB Owens, BD AF Wolf, Jennifer Moriatis Cameron, Kenneth L. Clifton, Kari B. Owens, Brett D. TI Serum Relaxin Levels in Young Athletic Men Are Comparable With Those in Women SO ORTHOPEDICS LA English DT Article ID ANTERIOR CRUCIATE LIGAMENT; MENSTRUAL-CYCLE; DISEASE; PREGNANCY; RECEPTORS; PROSTATE; FIBROSIS; BINDING AB Relaxin was originally described as a reproductive hormone that mediated joint laxity in pregnant women and has been minimally studied in men. The purpose of this descriptive laboratory and clinical study was to evaluate serum relaxin in a young, primarily male population and compare levels between the sexes. In addition, the authors evaluated the relationship between relaxin and generalized laxity. C1 [Wolf, Jennifer Moriatis; Clifton, Kari B.] Univ Connecticut, Ctr Hlth, Dept Orthopaed Surg, Farmington, CT 06030 USA. [Cameron, Kenneth L.; Owens, Brett D.] United States Mil Acad, Keller Army Hosp, West Point, NY USA. RP Wolf, JM (reprint author), Univ Connecticut, Ctr Hlth, Dept Orthopaed Surg, 263 Farmington Ave, Farmington, CT 06030 USA. EM jmwolf@uchc.edu OI Cameron, Kenneth/0000-0002-6276-4482 FU Prospective Research Grant from the Orthopaedic Research and Education Foundation; Connecticut Institute of Clinical and Translational Science (Clinical Research Center Grant) [M01RR006192] FX This study was supported by a Prospective Research Grant from the Orthopaedic Research and Education Foundation (BDO) and pilot funding from the Connecticut Institute of Clinical and Translational Science (Clinical Research Center Grant #M01RR006192) (JMW). NR 21 TC 6 Z9 7 U1 0 U2 4 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0147-7447 J9 ORTHOPEDICS JI Orthopedics PD FEB PY 2013 VL 36 IS 2 BP 128 EP 131 DI 10.3928/01477447-20130122-06 PG 4 WC Orthopedics SC Orthopedics GA 093PW UT WOS:000315204800030 PM 23379736 ER PT J AU Janosi, L Compton, JR Legler, PM Steele, KE Davis, JM Matyas, GR Millard, CB AF Janosi, Laszlo Compton, Jaimee R. Legler, Patricia M. Steele, Keith E. Davis, Jon M. Matyas, Gary R. Millard, Charles B. TI Disruption of the Putative Vascular Leak Peptide Sequence in the Stabilized Ricin Vaccine Candidate RTA1-33/44-198 SO TOXINS LA English DT Article DE ricin; recombinant vaccines; vascular leak peptide; amino acid substitutions; BALB/c mice; D75N/R48C/T77C; RTA1-33/44-198 ID A-CHAIN; MOLECULAR-GRAPHICS; PROTEIN VACCINE; MICE; INHALATION; PROTECTION; ANTIBODIES; EFFICACY; AEROSOL; BINDING AB Vitetta and colleagues identified and characterized a putative vascular leak peptide (VLP) consensus sequence in recombinant ricin toxin A-chain (RTA) that contributed to dose-limiting human toxicity when RTA was administered intravenously in large quantities during chemotherapy. We disrupted this potentially toxic site within the more stable RTA1-33/44-198 vaccine immunogen and determined the impact of these mutations on protein stability, structure and protective immunogenicity using an experimental intranasal ricin challenge model in BALB/c mice to determine if the mutations were compatible. Single amino acid substitutions at the positions corresponding with RTA D75 (to A, or N) and V76 (to I, or M) had minor effects on the apparent protein melting temperature of RTA1-33/44-198 but all four variants retained greater apparent stability than the parent RTA. Moreover, each VLP(-) variant tested provided protection comparable with that of RTA1-33/44-198 against supralethal intranasal ricin challenge as judged by animal survival and several biomarkers. To understand better how VLP substitutions and mutations near the VLP site impact epitope structure, we introduced a previously described thermal stabilizing disulfide bond (R48C/T77C) along with the D75N or V76I substitutions in RTA1-33/44-198. The D75N mutation was compatible with the adjacent stabilizing R48C/T77C disulfide bond and the T-m was unaffected, whereas the V76I mutation was less compatible with the adjacent disulfide bond involving C77. A crystal structure of the RTA1-33/44-198 R48C/T77C/D75N variant showed that the structural integrity of the immunogen was largely conserved and that a stable immunogen could be produced from E. coli. We conclude that it is feasible to disrupt the VLP site in RTA1-33/44-198 with little or no impact on apparent protein stability or protective efficacy in mice and such variants can be stabilized further by introduction of a disulfide bond. C1 [Janosi, Laszlo; Steele, Keith E.; Matyas, Gary R.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Compton, Jaimee R.] NOVA Res Inc, Alexandria, VA 22308 USA. [Legler, Patricia M.] USN, Res Labs, Washington, DC 20375 USA. [Davis, Jon M.] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Millard, Charles B.] USA, Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP Legler, PM (reprint author), USN, Res Labs, 4555 Overlook Ave, Washington, DC 20375 USA. EM lacipaci@yahoo.com; jaimee.compton.ctr@nrl.navy.mil; patricia.legler@nrl.navy.mil; steeleK@medImmune.com; jon.davis@osd.mil; gmatyas@hivresearch.org; charles.b.millard@us.army.mil OI Matyas, Gary/0000-0002-2074-2373 FU U.S. Army; Defense Threat Reduction Agency (DTRA) Joint Science & Technology Office award [S.S.0003_06_WR_B]; National Institutes of Health (NIH) [5U01AI082120-04] FX We would like to thank Paul Facemire for providing photographs of healthy lung tissue. This work was supported by the U.S. Army and a Defense Threat Reduction Agency (DTRA) Joint Science & Technology Office award S.S.0003_06_WR_B (to CBM) and National Institutes of Health (NIH) sub-award 5U01AI082120-04 (to PML). The opinions or assertions contained herein belong to the authors and are not necessarily the official views of the U.S. Army, U.S. Navy, the U.S. Department of Defense, or the NIH. NR 31 TC 1 Z9 2 U1 1 U2 6 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2072-6651 J9 TOXINS JI Toxins PD FEB PY 2013 VL 5 IS 2 BP 224 EP 248 DI 10.3390/toxins5020224 PG 25 WC Toxicology SC Toxicology GA 096MJ UT WOS:000315408000002 PM 23364220 ER PT J AU Swierczewski, BE Odundo, EA Koech, MC Ndonye, JN Kirera, RK Odhiambo, CP Cheruiyot, EK Wu, MT Lee, JE Zhang, CL Oaks, EV AF Swierczewski, Brett E. Odundo, Elizabeth A. Koech, Margaret C. Ndonye, Janet N. Kirera, Ronald K. Odhiambo, Cliff P. Cheruiyot, Erick K. Wu, Max T. Lee, James E. Zhang, Chunlin Oaks, Edwin V. TI Surveillance for enteric pathogens in a case-control study of acute diarrhea in Western Kenya SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article DE Gastroenteritis; Protozoa; Rotavirus; Shigella; Escherichia coli; Antimicrobial resistance ID SPECTRUM BETA-LACTAMASE; ESCHERICHIA-COLI; CHILDHOOD DIARRHEA; GIARDIA-LAMBLIA; ANTIMICROBIAL RESISTANCE; DEVELOPING-COUNTRIES; PERSISTENT DIARRHEA; BACTERIAL DIARRHEA; FECAL SPECIMENS; HIGH PREVALENCE AB Background: Acute diarrhea remains a major public health problem in East African nations such as Kenya. Surveillance for a broad range of enteric pathogens is necessary to accurately predict the frequency of pathogens and potential changes in antibiotic resistance patterns. Method: Stool samples were collected from September 2009 to September 2011; 193 and 239 samples, from age-matched cases and asymptomatic controls, were collected, respectively, from Kericho and Kisumu District Hospitals in western Kenya. Bacterial pathogens were identified by conventional microbiological methods; antibiotic susceptibility of bacterial isolates was ascertained using the Micro Scan Walk Away 40 Plus. An enzyme immunoassay kit was used to detect rotavirus, and ova and parasite examination was conducted by microscopy and an enzyme immunoassay. Results: Rotavirus (10.2% and 10.5%) and Shigella (11% and 8%) were isolated significantly more often in the cases than the controls from Kericho and Kisumu District Hospitals respectively. The diarrheagenic Escherichia coli, Campylobacter jejuni and Salmonella were found most often in the cases while Giardia lamblia and Entamoeba histolytica/E. dispar were found more often in the controls. Most pathogens were isolated from children under 5 years old. More than 50% of the Shigella, Salmonella and diarrheagenic E. coli isolates were multidrug resistant to ampicillin, tetracycline and trimethoprim/sulfamethoxazole with several enteroaggregative and enterotoxigenic E. coli isolates producing extended-spectrum beta-lactamases. Conclusion: Accurate epidemiologic information on acute diarrheal illness in Kenya will be critical for augmenting existing diarrhea management policies in terms of treatment and to strengthen future community awareness and health promotion programs. C1 [Swierczewski, Brett E.; Odundo, Elizabeth A.; Koech, Margaret C.; Ndonye, Janet N.; Kirera, Ronald K.; Odhiambo, Cliff P.; Cheruiyot, Erick K.] US Army Med Res Unit Kenya, Kericho Field Stn, Chilung 20220, Taiwan. [Wu, Max T.; Lee, James E.; Zhang, Chunlin; Oaks, Edwin V.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD USA. RP Swierczewski, BE (reprint author), US Army Med Res Unit Kenya, Kericho Field Stn, POB 1357,Hosp Rd, Chilung 20220, Taiwan. EM brett.swierczewski@us.army.mil RI Valle, Ruben/A-7512-2013 FU Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance and Response Systems, Silver Spring, MD, USA FX This study was funded by the Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance and Response Systems, Silver Spring, MD, USA. NR 54 TC 9 Z9 10 U1 0 U2 17 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD FEB PY 2013 VL 107 IS 2 BP 83 EP 90 DI 10.1093/trstmh/trs022 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 095EX UT WOS:000315318600003 PM 23222955 ER PT J AU Ferguson, BK Ferguson, BK Mickalonis, O AF Ferguson, Bruce K. Ferguson, Benjamin K. Mickalonis, Olivia TI Aggregate selection and cost for impervious surface reduction SO URBAN WATER JOURNAL LA English DT Article DE permeable surfaces; aggregate; pervious surface; cost ID HYDRAULIC CONDUCTIVITY; KOZENY-CARMAN AB This paper investigates the possibility that some aggregate gradations could be considered functionally pervious', based on comparison of an aggregate's permeability with either natural soil permeabilities or local rainfall intensities. Permeability was estimated by calculation for 27 American standard gradations, based on their porosity, coefficient of uniformity and effective particle size. In addition aggregate's cost relative to other urban surfaces was estimated. The results show that gradations of ASTM D448 No. 9, 89 and larger have high permeabilities relative to both the most permeable soil and the most intense rainfall in the central and eastern United States and so could be considered pervious surfaces in that large region. Denser gradations have lower permeabilities and less claim to be considered pervious. Properly selected aggregate's combination of high permeability and low cost make it an attractive option for reducing impervious cover, under the detailed traffic types for which it is suited. C1 [Ferguson, Bruce K.] Univ Georgia, Coll Environm & Design, Athens, GA 30602 USA. [Ferguson, Benjamin K.] Paul C Rizzo Associates, Pittsburgh, PA USA. [Mickalonis, Olivia] USA, Directorate Publ Works, Ft Stewart, GA USA. RP Ferguson, BK (reprint author), Univ Georgia, Coll Environm & Design, Athens, GA 30602 USA. EM bfergus@uga.edu NR 28 TC 0 Z9 0 U1 2 U2 7 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1573-062X J9 URBAN WATER J JI Urban Water J. PD FEB 1 PY 2013 VL 10 IS 1 BP 62 EP 69 DI 10.1080/1573062X.2012.682592 PG 8 WC Water Resources SC Water Resources GA 093LM UT WOS:000315193400005 ER PT J AU Gottfried, JL AF Gottfried, Jennifer L. TI Influence of metal substrates on the detection of explosive residues with laser-induced breakdown spectroscopy SO APPLIED OPTICS LA English DT Article ID ORGANIC-COMPOUNDS; CLASSIFICATION; ABLATION; PLASMA; DISCRIMINATION; SPECTRA; RDX AB Laser-induced breakdown spectroscopy is a promising approach for explosive residue detection, but several limitations to its widespread use remain. One issue is that the emission spectra of the residues are dependent on the substrate composition because some of the substrate is usually entrained in the laser-induced plasma and the laser-material interaction can be significantly affected by the substrate type. Here, we have demonstrated that despite the strong spectral variation in cyclotrimethylenetrinitramine (RDX) residues applied to various metal substrates, classification of the RDX residue independent of substrate type is feasible. Several approaches to improving the chemometric models based on partial least squares discriminant analysis (PLS-DA) have been described: classifying the RDX residue spectra together in one class independent of substrate, using selected emission intensities and ratios to increase the true positive rate (TPR) and decrease the false positive rate (FPR), and fusing the results from two PLS-DA models generated using the full broadband spectra and selected intensities and ratios. The combination of these approaches resulted in a TPR of 97.5% and a FPR of 1.0% for RDX classification on metal substrates. C1 USA, Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. RP Gottfried, JL (reprint author), USA, Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. EM jennifer.gottfried@us.army.mil RI Gottfried, Jennifer/G-6333-2010 NR 31 TC 12 Z9 13 U1 2 U2 31 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD FEB 1 PY 2013 VL 52 IS 4 BP B10 EP B19 DI 10.1364/AO.52.000B10 PG 10 WC Optics SC Optics GA 086LH UT WOS:000314684600003 PM 23385936 ER PT J AU McLurkin, J Rykowski, J John, M Kaseman, Q Lynch, AJ AF McLurkin, James Rykowski, Joshua John, Meagan Kaseman, Quillan Lynch, Andrew J. TI Using Multi-Robot Systems for Engineering Education: Teaching and Outreach With Large Numbers of an Advanced, Low-Cost Robot SO IEEE TRANSACTIONS ON EDUCATION LA English DT Article DE Engineering; multi-robot systems; problem-based learning; outreach; robotics education AB This paper describes the experiences of using an advanced, low-cost robot in science, technology, engineering, and mathematics (STEM) education. It presents three innovations: It is a powerful, cheap, robust, and small advanced personal robot; it forms the foundation of a problem-based learning curriculum; and it enables a novel multi-robot curriculum while fostering collaborative team work on assignments. The robot design has many features specific to educators: It is advanced enough for academic research, has a broad feature set to support a wide range of curricula, and is inexpensive enough to be an effective outreach tool. The low cost allows each student to have their own robot for the semester, so they can work on activities outside the classroom. This robot was used in three different classes in which it was the foundation for an innovative problem-based learning curriculum. In particular, the robot has specialized sensors and a communications system that supports novel multi-robot curricula, which encourage student interaction in new ways. The results are promising; the robot was a big success in graduate, undergraduate, and outreach activities. Finally, student assessments indicate a greater interest and understanding of engineering and other STEM majors, and class evaluations were consistently above average. C1 [McLurkin, James; John, Meagan; Kaseman, Quillan; Lynch, Andrew J.] Rice Univ, Dept Comp Sci, Houston, TX 77005 USA. [Rykowski, Joshua] US Mil Acad, Dept Comp Sci, West Point, NY 10996 USA. RP McLurkin, J (reprint author), Rice Univ, Dept Comp Sci, Houston, TX 77005 USA. EM jmclurkin@rice.edu; joshua.rykowski@usma.edu; maj5@rice.edu; quillan.t.kaseman@rice.edu; lyncas@gmail.com NR 35 TC 22 Z9 22 U1 8 U2 59 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9359 J9 IEEE T EDUC JI IEEE Trans. Educ. PD FEB PY 2013 VL 56 IS 1 SI SI BP 24 EP 33 DI 10.1109/TE.2012.2222646 PG 10 WC Education, Scientific Disciplines; Engineering, Electrical & Electronic SC Education & Educational Research; Engineering GA 088JI UT WOS:000314829800005 ER PT J AU Gonzalez, RR Kenefick, RW Muza, SR Hamilton, SW Sawka, MN AF Gonzalez, Richard R. Kenefick, Robert W. Muza, Stephen R. Hamilton, Scott W. Sawka, Michael N. TI Sweat rate and prediction validation during high-altitude treks on Mount Kilimanjaro SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE solar load; hypobaric environments; water requirements; modeling prediction analyses ID HEAT-STRESS; EXERCISE PERFORMANCE; ENERGY-EXPENDITURE; WATER NEEDS; TEMPERATURE; MECHANISMS; EXPOSURE; HYPOHYDRATION; ENVIRONMENTS; DEHYDRATION AB Gonzalez RR, Kenefick RW, Muza SR, Hamilton SW, Sawka MN. Sweat rate and prediction validation during high-altitude treks on Mount Kilimanjaro. J Appl Physiol 114: 436-443, 2013. First published December 27, 2012; doi: 10.1152/japplphysiol.01176.2012.This study measured sweat rates (m(sw)) during high-altitude summer treks on Mt. Kilimanjaro to evaluate the efficacy of a recently developed fuzzy piecewise sweat prediction equation ((P) over dotw,sol) for application to high-altitude conditions. We hypothesized that the (P) over dotw,sol equation, adjusted for the barometric pressure (P-B) decreasing steadily at high altitude ((P) over dotw,sol + Alt), would allow for a more accurate prediction of msw than (P) over dotw,sol unadjusted for altitude ((P) over dotw,sol(SL)). Fifteen men (43 +/- 16 yr; 80 +/- 22 kg) and seven women (46 +/- 16 yr; 77 +/- 18 kg) wearing hiking clothes (clo similar to 1.15; clothing evaporative potential = 0.27) and carrying light loads (9 +/- 2 kg), were studied during morning and afternoon treks (similar to 2-3 h) while ascending from 2,829 m to 3,505 m. After each trek, msw was measured with specific biophysical parameters at 15-min intervals. During the trek day, P-B progressively declined (530 to 504 Torr), as solar radiation and ambient temperature (degrees C) rose transiently. During all treks, msw ranged from 68 to 393 g.m(-2).h(-1) (0.14 to 0.79 l/h). For each subject, derived (P) over dotw,sol(SL) and (P) over dotw,sol+Alt model outputs accurately predicted the morning and afternoon average m(sw) within a root mean square error of 0.145 l/h. No differences were found between (P) over dotw, sol(SL) and (P) over dotw,sol+Alt values. In conclusion, we report the first msw measured during outdoor high-altitude activities and determined that (P) over dotw,sol(SL) equation can be used to predict fluid needs during high-altitude activities without alterations for lower P-B. This model prediction provides a valid water planning tool for outdoor activities at high altitude up to 3,500 m. C1 [Gonzalez, Richard R.] New Mexico State Univ, Dept Biol, Las Cruces, NM 88003 USA. [Kenefick, Robert W.; Muza, Stephen R.; Hamilton, Scott W.; Sawka, Michael N.] USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Kenefick, RW (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St, Natick, MA 01760 USA. EM robert.kenefick@us.army.mil FU US Army Medical Research and Material Command FX This study was a flag expedition of The Explorers Club, New York City, NY, and funding was provided by the US Army Medical Research and Material Command. NR 36 TC 3 Z9 3 U1 1 U2 19 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD FEB PY 2013 VL 114 IS 4 BP 436 EP 443 DI 10.1152/japplphysiol.01176.2012 PG 8 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 092KA UT WOS:000315118300002 PM 23271696 ER PT J AU Estrada, AX Dirosa, GA Decostanza, AH AF Estrada, Armando X. Dirosa, Gia A. Decostanza, Arwen H. TI Gays in the U.S. Military: Reviewing the Research and Conceptualizing a Way Forward SO JOURNAL OF HOMOSEXUALITY LA English DT Article DE gays; sexual orientation; military service; Don't Ask Don't Tell; DADT ID WORKPLACE SEXUAL-HARASSMENT; INTERGROUP CONTACT; BENEVOLENT SEXISM; MERE EXPOSURE; HETEROSEXUALS ATTITUDES; WOMEN; METAANALYSIS; PERFORMANCE; DISCLOSURE; PERSONNEL AB This article contributes to ongoing discussions related to the challenges and opportunities associated with the participation and inclusion of openly gay service personnel within the U.S. military. The article reviews research related to sexual orientation and military service and outlines a theory of the antecedents and outcomes of open integration of gays in the military environment. We discuss implications of this theory for future research in this area. C1 [Estrada, Armando X.; Dirosa, Gia A.; Decostanza, Arwen H.] USA, Res Inst Behav & Social Sci, Aberdeen Proving Ground, MD 21005 USA. RP Estrada, AX (reprint author), USA, Res Inst, Fdn Sci Res Unit DAPE ARI FS, 6010 Frankford St,Off 221, Aberdeen Proving Ground, MD 21005 USA. EM aestrada1@vancouver.wsu.edu NR 103 TC 2 Z9 2 U1 2 U2 14 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0091-8369 J9 J HOMOSEXUAL JI J. Homosex. PD FEB 1 PY 2013 VL 60 IS 2-3 SI SI BP 327 EP 355 DI 10.1080/00918369.2013.744676 PG 29 WC Psychology, Multidisciplinary; Social Sciences, Interdisciplinary SC Psychology; Social Sciences - Other Topics GA 089NL UT WOS:000314917200011 PM 23414276 ER PT J AU Poret, JC Shaw, AP Csernica, CM Oyler, KD Estes, DP AF Poret, Jay C. Shaw, Anthony P. Csernica, Christopher M. Oyler, Karl D. Estes, Deven P. TI Development and Performance of the W/Sb2O3/KIO4/Lubricant Pyrotechnic Delay in the US Army Hand-Held Signal SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Pyrotechnic delays; Tungsten; Periodate; Hand-held signal AB Gassy pyrotechnic delays composed of tungsten, antimony(III) oxide, potassium periodate, and various lubricants have been developed for use in the US Army hand-held signal. The new compositions were developed to replace the current formulation, which contains potassium perchlorate and barium chromate, chemicals that are facing increasing scrutiny due to environmental regulation. The hand-held signal delay housing was used to demonstrate the burning rate tunability of the new compositions. The addition of 15% of waxy lubricants (stearic acid or calcium stearate) was found to have a profound effect on burning rate. The effect of tungsten content and the Sb2O3/KIO4 ratio on burning rate was also probed. A wide range of inverse burning rates (2 to 15scm1) were demonstrated, which encompasses the 7 to 8.5scm1 range required by the hand-held signal. The W/KIO4 reaction produces I2, which was observed by visible spectroscopy in the vapor above a sample of combustion residue. C1 [Poret, Jay C.; Shaw, Anthony P.; Csernica, Christopher M.] US Army, RDECOM ARDEC, Pyrotech Technol & Prototyping Div, Picatinny Arsenal, NJ 07806 USA. [Oyler, Karl D.] US Army, RDECOM ARDEC, Explos Technol & Prototyping Div, Picatinny Arsenal, NJ 07806 USA. [Estes, Deven P.] Columbia Univ, Dept Chem, New York, NY 10027 USA. RP Poret, JC (reprint author), US Army, RDECOM ARDEC, Pyrotech Technol & Prototyping Div, Picatinny Arsenal, NJ 07806 USA. EM anthony.p.shaw.civ@mail.mil FU US Army through the Environmental Quality Technology (EQT) Program FX The authors thank the US Army for funding this project through the Environmental Quality Technology (EQT) Program. NR 25 TC 12 Z9 12 U1 0 U2 7 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 0721-3115 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD FEB PY 2013 VL 38 IS 1 BP 35 EP 40 DI 10.1002/prep.201200109 PG 6 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA 090QO UT WOS:000314994200005 ER PT J AU Ioannou, A Lieberman, LA Lucca, JJD Tsokos, GC AF Ioannou, Antonis Lieberman, Linda A. Lucca, Jurandir J. Dalle Tsokos, George C. TI Complement depletion protects lupus-prone mice from ischemia-reperfusion-initiated organ injury SO AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY LA English DT Article DE ischemia-reperfusion injury; intestine; complement; systemic lupus erythematosus ID ISCHEMIA/REPERFUSION-INDUCED INJURY; LUNG-TISSUE DAMAGE; COBRA VENOM FACTOR; MYOCARDIAL-ISCHEMIA; BINDING LECTIN; 2 PARTS; C5A; ERYTHEMATOSUS; ACTIVATION; HEMORRHAGE AB Ioannou A, Lieberman LA, Dalle Lucca JJ, Tsokos GC. Complement depletion protects lupus-prone mice from ischemia-reperfusion-initiated organ injury. Am J Physiol Gastrointest Liver Physiol 304: G283-G292, 2013. First published October 25, 2012; doi:10.1152/ajpgi.00371.2012.-Ischemia-reperfusion (IR) injury causes a vigorous immune response that is amplified by complement activation, leading to local and remote tissue damage. Using MRL/lpr mice, which are known to experience accelerated tissue damage after mesenteric IR injury, we sought to evaluate whether complement inhibition mitigates organ damage. We found that complement depletion with cobra venom factor protected mice from local and remote lung tissue damage. Protection from injury was associated with less complement (C3) and membrane attack complex deposition, less neutrophil infiltration, and lower levels of local proinflammatory cytokine production. In addition, complement depletion was able to decrease the level of oxidative stress as measured by glutathione peroxidase 1 mRNA levels and superoxide dismutase activity. Furthermore, blockage of C5a receptor protected MRL/lpr mice from local tissue damage, but not from remote lung tissue damage. In conclusion, although treatments with cobra venom factor and C5a receptor antagonist were able to protect mice from local tissue damage, treatment with C5a receptor antagonist was not able to protect mice from remote lung tissue damage, implying that more factors contribute to the development of remote tissue damage after IR injury. These data also suggest that complement inhibition at earlier, rather than late, stages can have clinical benefit in conditions that are complicated with IR injury. C1 [Ioannou, Antonis; Lieberman, Linda A.; Tsokos, George C.] Beth Israel Deaconess Med Ctr, Div Rheumatol, Boston, MA 02215 USA. [Ioannou, Antonis; Lieberman, Linda A.; Tsokos, George C.] Harvard Univ, Sch Med, Boston, MA 02115 USA. [Lucca, Jurandir J. Dalle] USA, Inst Surg Res, San Antonio, TX USA. [Ioannou, Antonis] Univ Crete, Sch Med, Dept Basic Sci, Iraklion, Crete, Greece. RP Ioannou, A (reprint author), Harvard Univ, Beth Israel Deaconess Med Ctr, Dept Med, Div Rheumatol,Med Sch, 330 Brookline Ave,CLS 928, Boston, MA 02115 USA. EM aioannou@bidmc.harvard.edu FU US Army Medical Research and Material Command [W81XWH-09-1-0530, W81XWH-09-1-0536] FX The research presented here was supported by US Army Medical Research and Material Command Grants W81XWH-09-1-0530 and W81XWH-09-1-0536. NR 57 TC 3 Z9 3 U1 0 U2 6 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0193-1857 J9 AM J PHYSIOL-GASTR L JI Am. J. Physiol.-Gastroint. Liver Physiol. PD FEB PY 2013 VL 304 IS 3 BP G283 EP G292 DI 10.1152/ajpgi.00371.2012 PG 10 WC Gastroenterology & Hepatology; Physiology SC Gastroenterology & Hepatology; Physiology GA 085WI UT WOS:000314644600007 PM 23104558 ER PT J AU Grogl, M Hickman, M Ellis, W Hudson, T Lazo, JS Sharlow, ER Johnson, J Berman, J Sciotti, RJ AF Grogl, Max Hickman, Mark Ellis, William Hudson, Thomas Lazo, John S. Sharlow, Elizabeth R. Johnson, Jacob Berman, Jonathan Sciotti, Richard J. TI Review: Drug Discovery Algorithm for Cutaneous Leishmaniasis SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Review ID HIGH-THROUGHPUT; IDENTIFICATION; AMASTIGOTES; DISEASE; SCREEN AB Cutaneous leishmaniasis is clinically widespread but lacks treatments that are effective and well tolerated. Because all present drugs have been grandfathered into clinical use, there are no examples of a pre-clinical product evaluation scheme that lead to new candidates for formal development. To provide oral agents for development targeting cutaneous leishmaniasis, we have implemented a discovery scheme that incorporates in vitro and in vivo testing of efficacy, toxicity, and pharmacokinetics/metabolism. Particular emphasis is placed on in vivo testing, progression from higher-throughput models to those with most clinical relevance, and efficient use of resources. C1 [Grogl, Max; Hickman, Mark; Ellis, William; Hudson, Thomas; Johnson, Jacob; Berman, Jonathan; Sciotti, Richard J.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. Univ Pittsburgh, Dept Pharmacol & Chem Biol, Pittsburgh, PA USA. Univ Virginia, Dept Pharmacol & Chem, Charlottesville, VA USA. RP Sciotti, RJ (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. EM max.grogll@us.army.mil; mark.r.hickman@us.army.mil; bill.ellis@us.army.mil; thomas.hudson@us.army.mil; jjohnson@wrp-ksm.org; ers7g@virginia.edu; jsl8f@hscmail.mcc.virginia.edu; jbe9320457@aol.com; richard.sciotti@us.army.mil RI Sciotti, Richard/A-9069-2011; Hudson, Thomas/A-9152-2011 NR 19 TC 11 Z9 12 U1 1 U2 14 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 2013 VL 88 IS 2 BP 216 EP 221 DI 10.4269/ajtmh.11-0812 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 082ZG UT WOS:000314431900003 PM 23390221 ER PT J AU Grubaugh, ND Petz, LN Melanson, VR McMenamy, SS Turell, MJ Long, LS Pisarcik, SE Kengluecha, A Jaichapor, B O'Guinn, ML Lee, JS AF Grubaugh, Nathan D. Petz, Lawrence N. Melanson, Vanessa R. McMenamy, Scott S. Turell, Michael J. Long, Lewis S. Pisarcik, Sarah E. Kengluecha, Ampornpan Jaichapor, Boonsong O'Guinn, Monica L. Lee, John S. TI Evaluation of a Field-Portable DNA Microarray Platform and Nucleic Acid Amplification Strategies for the Detection of Arboviruses, Arthropods, and Bloodmeals SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID ELECTROCHEMICAL DETECTION; MOLECULAR-IDENTIFICATION; VIRUS IDENTIFICATION; PCR; MOSQUITOS; FLAVIVIRUSES; PATHOGENS; TRANSMISSION; CULICIDAE; INFLUENZA AB Highly multiplexed assays, such as microarrays, can benefit arbovirus surveillance by allowing researchers to screen for hundreds of targets at once. We evaluated amplification strategies and the practicality of a portable DNA microarray platform to analyze virus-infected mosquitoes. The prototype microarray design used here targeted the nonstructural protein 5, ribosomal RNA, and cytochrome b genes for the detection of flaviviruses, mosquitoes, and bloodmeals, respectively. We identified 13 of 14 flaviviruses from virus inoculated mosquitoes and cultured cells. Additionally, we differentiated between four mosquito genera and eight whole blood samples. The microarray platform was field evaluated in Thailand and successfully identified flaviviruses (Culex flavivirus, dengue-3, and Japanese encephalitis viruses), differentiated between mosquito genera (Aedes, Armigeres, Culex, and Mansonia), and detected mammalian bloodmeals (human and dog). We showed that the microarray platform and amplification strategies described here can be used to discern specific information on a wide variety of viruses and their vectors. C1 USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA. [Kengluecha, Ampornpan; Jaichapor, Boonsong] US Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok, Thailand. RP Lee, JS (reprint author), USA, Med Res & Mat Command, Mil Infect Dis Res Program, Bldg 722,504 Scott Ave, Frederick, MD 21702 USA. EM nathan.grubaugh@colostate.edu; lawrence.petz@us.army.mil; vanessa.melanson@us.army.mil; scott.mcmenamy@us.army.mil; michael.j.turell@us.army.mil; lewis.s.long@us.army.mil; sarah.pisarcik@us.army.mil; ampornpank@afrims.org; boonsongj@afrims.org; monica.oguinn@us.amiy.mil; john.s.lee@us.army.mil FU Military Infectious Disease Research Program project [U0176_09_RD] FX This research was funded by the Military Infectious Disease Research Program project no. U0176_09_RD and supported in part by an appointment to the Postgraduate Research Participation Program at USAMRIID administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and U.S. Army Medical Research and Material Command. NR 35 TC 6 Z9 6 U1 0 U2 29 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 2013 VL 88 IS 2 BP 245 EP 253 DI 10.4269/ajtmh.2012.12-0048 PG 9 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 082ZG UT WOS:000314431900009 PM 23249687 ER PT J AU Butler, LK Ries, L Bisson, IA Hayden, TJ Wikelski, MM Romero, LM AF Butler, L. K. Ries, L. Bisson, I. -A. Hayden, T. J. Wikelski, M. M. Romero, L. M. TI Opposite but analogous effects of road density on songbirds with contrasting habitat preferences SO ANIMAL CONSERVATION LA English DT Article DE edge effects; glucocorticoids; habitat fragmentation; roads; stress ID CORTICOSTERONE LEVELS; PIED FLYCATCHER; BEHAVIORAL NEUROENDOCRINOLOGY; ADRENOCORTICAL-RESPONSE; TERRITORIAL BEHAVIOR; REPRODUCTIVE SUCCESS; PHYSIOLOGICAL STRESS; HORMONAL RESPONSES; SEASONAL-CHANGES; FOREST AB Roads are a widespread and growing form of habitat alteration, making their effects on wildlife a major conservation concern. We investigated effects of roads on occupancy patterns and stress physiology of the golden-cheeked warbler Setophaga chrysoparia, an endangered songbird that depends on large tracts of old-growth forest for breeding. We compared those effects in the white-eyed vireo Vireo griseus, a common songbird that prefers to breed in scrubby habitat that is common along forest roads. In warblers, older, socially dominant males were more likely to occupy territories, but had higher baseline plasma concentrations of corticosterone, in less-roaded habitats. In vireos, older males were equally likely to occupy territories, but, opposite to warblers, had lower baseline corticosterone concentrations, in less-roaded habitats. In both species, the corticosterone response to acute stress was unrelated to road density, and body condition and fat stores either increased or were sustained across road density groups during the breeding season, suggesting that breeding near roads did not cause chronic stress. Our results suggest that roads can cause increased malemale competition for territories in nearby roadless habitat, and may result in higher corticosterone concentrations in dominant individuals defending preferred sites near or far from edge, depending on species habitat preferences. Increased competition and chronically elevated corticosterone levels may be of concern if they alter parental care or immunity of individuals breeding in the best habitat. C1 [Butler, L. K.; Romero, L. M.] Coll New Jersey, Dept Biol, Ewing, NJ 08628 USA. [Ries, L.] Univ Maryland, Dept Biol, College Pk, MD 20742 USA. [Bisson, I. -A.; Wikelski, M. M.] Princeton Univ, Dept Ecol & Evolutionary Biol, Princeton, NJ 08544 USA. [Hayden, T. J.] Engn Res & Dev Ctr, Champaign, IL USA. RP Butler, LK (reprint author), Coll New Jersey, Dept Biol, 2000 Pennington Rd, Ewing, NJ 08628 USA. EM lbutler@tcnj.edu FU Strategic Environmental Research and Development Program [SI-1396, SI-1597] FX Funding was provided by the Strategic Environmental Research and Development Program (SI-1396 and SI-1597), but does not necessarily reflect the position or views of the US government. Roads and trails were digitized by A. Doherty. Imagery was received from M. Noble of The Nature Conservancy at Ft. Hood. E. Gill made distinguished contributions to the field work. L. Glassman, J. Ferrer, M. Vinson, and A. Whitley also assisted with field experiments. M. Dickens and N. Cyr assisted with assays, and J. Reed assisted with statistics. Two anonymous reviewers made suggestions that improved the manuscript. NR 60 TC 2 Z9 2 U1 3 U2 53 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1367-9430 J9 ANIM CONSERV JI Anim. Conserv. PD FEB PY 2013 VL 16 IS 1 BP 77 EP 85 DI 10.1111/j.1469-1795.2012.00576.x PG 9 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 079LJ UT WOS:000314171600011 ER PT J AU Drezner, JA Ackerman, MJ Anderson, J Ashley, E Asplund, CA Baggish, AL Borjesson, M Cannon, BC Corrado, D DiFiori, JP Fischbach, P Froelicher, V Harmon, KG Heidbuchel, H Marek, J Owens, DS Paul, S Pelliccia, A Prutkin, JM Salerno, JC Schmied, CM Sharma, S Stein, R Vetter, VL Wilson, MG AF Drezner, Jonathan A. Ackerman, Michael John Anderson, Jeffrey Ashley, Euan Asplund, Chad A. Baggish, Aaron L. Borjesson, Mats Cannon, Bryan C. Corrado, Domenico DiFiori, John P. Fischbach, Peter Froelicher, Victor Harmon, Kimberly G. Heidbuchel, Hein Marek, Joseph Owens, David S. Paul, Stephen Pelliccia, Antonio Prutkin, Jordan M. Salerno, Jack C. Schmied, Christian M. Sharma, Sanjay Stein, Ricardo Vetter, Victoria L. Wilson, Mathew G. TI Electrocardiographic interpretation in athletes: the 'Seattle Criteria' SO BRITISH JOURNAL OF SPORTS MEDICINE LA English DT Article ID ECG INTERPRETATION; ACCURACY AB Sudden cardiac death (SCD) is the leading cause of death in athletes during sport. Whether obtained for screening or diagnostic purposes, an ECG increases the ability to detect underlying cardiovascular conditions that may increase the risk for SCD. In most countries, there is a shortage of physician expertise in the interpretation of an athlete's ECG. A critical need exists for physician education in modern ECG interpretation that distinguishes normal physiological adaptations in athletes from abnormal findings suggestive of pathology. On 13-14 February 2012, an international group of experts in sports cardiology and sports medicine convened in Seattle, Washington, to define contemporary standards for ECG interpretation in athletes. The objective of the meeting was to develop a comprehensive training resource to help physicians distinguish normal ECG alterations in athletes from abnormal ECG findings that require additional evaluation for conditions associated with SCD. C1 [Drezner, Jonathan A.; Harmon, Kimberly G.] Univ Washington, Dept Family Med, Seattle, WA 98195 USA. [Ackerman, Michael John] Mayo Clin, Dept Med, Div Cardiovasc Dis, Rochester, MN USA. [Ackerman, Michael John] Mayo Clin, Dept Pediat, Div Cardiovasc Dis, Rochester, MN USA. [Ackerman, Michael John] Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Div Cardiovasc Dis, Rochester, MN USA. [Ackerman, Michael John] Mayo Clin, Div Pediat Cardiol, Rochester, MN USA. [Anderson, Jeffrey] Univ Connecticut, Dept Athlet, Storrs, CT USA. [Ashley, Euan; Froelicher, Victor] Stanford Univ, Sch Med, Div Cardiovasc Med, Palo Alto, CA 94304 USA. [Asplund, Chad A.] Eisenhower Army Med Ctr, Dept Family Med, Ft Gordon, GA USA. [Baggish, Aaron L.] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA. [Borjesson, Mats] Karolinska Univ Hosp, Swedish Sch Sports & Hlth Sci, Dept Cardiol, Stockholm, Sweden. [Cannon, Bryan C.] Mayo Clin, Div Cardiovasc Dis, Rochester, MN USA. [Corrado, Domenico] Univ Padua, Dept Cardiac Thorac & Vasc Sci, Padua, Italy. [DiFiori, John P.] Univ Calif Los Angeles, Dept Family Med, Div Sports Med, Los Angeles, CA USA. [Fischbach, Peter] Emory Univ, Sch Med, Dept Pediat, Childrens Healthcare Atlanta, Atlanta, GA USA. [Heidbuchel, Hein] Univ Louvain, Dept Cardiovasc Sci, Louvain, Belgium. [Marek, Joseph] Midwest Heart Fdn, Oak Brook Terrace, IL USA. [Owens, David S.; Prutkin, Jordan M.] Univ Washington, Div Cardiol, Seattle, WA 98195 USA. [Paul, Stephen] Univ Arizona, Dept Family & Community Med, Tucson, AZ USA. [Pelliccia, Antonio] Inst Sport Med & Sci, Dept Med, Rome, Italy. [Salerno, Jack C.] Seattle Childrens Hosp, Div Cardiol, Seattle, WA USA. [Schmied, Christian M.] Univ Zurich Hosp, Ctr Cardiovasc, Div Cardiol, CH-8091 Zurich, Switzerland. [Sharma, Sanjay] St Georges Univ London, Dept Cardivasc Sci, London, England. [Stein, Ricardo] Hosp Clin Porto Alegre, Dept Cardiol, Porto Alegre, RS, Brazil. [Vetter, Victoria L.] Childrens Hosp Philadelphia, Div Cardiol, Philadelphia, PA 19104 USA. [Wilson, Mathew G.] Qatar Orthoped & Sports Med Hosp, ASPETAR, Dept Sports Med, Doha, Qatar. RP Drezner, JA (reprint author), Univ Washington, Dept Family Med, 1959 NE Pacific St,Box 356390, Seattle, WA 98195 USA. EM jdrezner@uw.edu OI Borjesson, Mats/0000-0002-8786-0438; Owens, David/0000-0002-7293-9688 NR 11 TC 166 Z9 169 U1 4 U2 34 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0306-3674 J9 BRIT J SPORT MED JI Br. J. Sports Med. PD FEB PY 2013 VL 47 IS 3 BP 122 EP 124 DI 10.1136/bjsports-2012-092067 PG 3 WC Sport Sciences SC Sport Sciences GA 081VE UT WOS:000314349700002 PM 23303758 ER PT J AU Drezner, JA Fischbach, P Froelicher, V Marek, J Pelliccia, A Prutkin, JM Schmied, CM Sharma, S Wilson, MG Ackerman, MJ Anderson, J Ashley, E Asplund, CA Baggish, AL Borjesson, M Cannon, BC Corrado, D DiFiori, JP Harmon, KG Heidbuchel, H Owens, DS Paul, S Salerno, JC Stein, R Vetter, VL AF Drezner, Jonathan A. Fischbach, Peter Froelicher, Victor Marek, Joseph Pelliccia, Antonio Prutkin, Jordan M. Schmied, Christian M. Sharma, Sanjay Wilson, Mathew G. Ackerman, Michael John Anderson, Jeffrey Ashley, Euan Asplund, Chad A. Baggish, Aaron L. Borjesson, Mats Cannon, Bryan C. Corrado, Domenico DiFiori, John P. Harmon, Kimberly G. Heidbuchel, Hein Owens, David S. Paul, Stephen Salerno, Jack C. Stein, Ricardo Vetter, Victoria L. TI Normal electrocardiographic findings: recognising physiological adaptations in athletes SO BRITISH JOURNAL OF SPORTS MEDICINE LA English DT Article ID EARLY REPOLARIZATION PATTERN; HYPERTROPHIC CARDIOMYOPATHY; CLINICAL-SIGNIFICANCE; ECG; PREVALENCE; HEART; CRITERIA; POPULATION; CARDIOLOGY; CONDUCTION AB Electrocardiographic changes in athletes are common and usually reflect benign structural and electrical remodelling of the heart as a physiological adaptation to regular and sustained physical training (athlete's heart). The ability to identify an abnormality on the 12-lead ECG, suggestive of underlying cardiac disease associated with sudden cardiac death (SCD), is based on a sound working knowledge of the normal ECG characteristics within the athletic population. This document will assist physicians in identifying normal ECG patterns commonly found in athletes. The ECG findings presented as normal in athletes were established by an international consensus panel of experts in sports cardiology and sports medicine. C1 [Drezner, Jonathan A.; Fischbach, Peter; Harmon, Kimberly G.] Univ Washington, Dept Family Med, Seattle, WA 98195 USA. [Fischbach, Peter] Emory Univ, Sch Med, Dept Pediat, Childrens Healthcare Atlanta, Atlanta, GA USA. [Froelicher, Victor; Ashley, Euan] Stanford Univ, Sch Med, Div Cardiovasc Med, Palo Alto, CA 94304 USA. [Marek, Joseph] Midwest Heart Fdn, Oak Brook Terrace, IL USA. [Pelliccia, Antonio] Inst Sport Med & Sci, Dept Med, Rome, Italy. [Prutkin, Jordan M.; Owens, David S.] Univ Washington, Div Cardiol, Seattle, WA 98195 USA. [Schmied, Christian M.] Univ Zurich Hosp, Div Cardiol, CH-8091 Zurich, Switzerland. [Sharma, Sanjay] St Georges Univ London, Dept Cardivasc Sci, London, England. [Wilson, Mathew G.] Qatar Orthoped & Sports Med Hosp, ASPETAR, Dept Sports Med, Doha, Qatar. [Ackerman, Michael John] Mayo Clin, Dept Med, Div Cardiovasc Dis, Rochester, MN USA. [Ackerman, Michael John] Mayo Clin, Dept Med, Dept Pediat Cardiol, Rochester, MN USA. [Ackerman, Michael John] Mayo Clin, Dept Pediat, Rochester, MN USA. [Ackerman, Michael John] Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN USA. [Anderson, Jeffrey] Univ Connecticut, Dept Athlet, Storrs, CT USA. [Asplund, Chad A.] Eisenhower Army Med Ctr, Dept Family Med, Ft Gordon, GA USA. [Baggish, Aaron L.] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA. [Borjesson, Mats] Karolinska Univ Hosp, Swedish Sch Sports & Hlth Sci, Dept Cardiol, Stockholm, Sweden. [Cannon, Bryan C.] Mayo Clin, Div Cardiovasc Dis, Rochester, MN USA. [Corrado, Domenico] Univ Padua, Dept Cardiac Thorac & Vasc Sci, Padua, Italy. [DiFiori, John P.] Univ Calif Los Angeles, Div Sports Med, Los Angeles, CA USA. [Heidbuchel, Hein] Univ Louvain, Dept Cardiovasc Sci, Louvain, Belgium. [Paul, Stephen] Univ Arizona, Dept Family & Community Med, Tucson, AZ USA. [Salerno, Jack C.] Seattle Childrens Hosp, Div Cardiol, Seattle, WA USA. [Stein, Ricardo] Hosp Clin Porto Alegre, Dept Cardiol, Porto Alegre, RS, Brazil. [Vetter, Victoria L.] Childrens Hosp Philadelphia, Div Cardiol, Philadelphia, PA 19104 USA. RP Drezner, JA (reprint author), Univ Washington, Dept Family Med, 1959 NE Pacific St,Box 356390, Seattle, WA 98195 USA. EM jdrezner@uw.edu OI Borjesson, Mats/0000-0002-8786-0438; Owens, David/0000-0002-7293-9688 NR 35 TC 48 Z9 50 U1 0 U2 19 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0306-3674 J9 BRIT J SPORT MED JI Br. J. Sports Med. PD FEB PY 2013 VL 47 IS 3 BP 125 EP + DI 10.1136/bjsports-2012-092068 PG 13 WC Sport Sciences SC Sport Sciences GA 081VE UT WOS:000314349700003 PM 23303759 ER PT J AU Drezner, JA Ashley, E Baggish, AL Borjesson, M Corrado, D Owens, DS Patel, A Pelliccia, A Vetter, VL Ackerman, MJ Anderson, J Asplund, CA Cannon, BC DiFiori, J Fischbach, P Froelicher, V Harmon, KG Heidbuchel, H Marek, J Paul, S Prutkin, JM Salerno, JC Schmied, CM Sharma, S Stein, R Wilson, M AF Drezner, Jonathan A. Ashley, Euan Baggish, Aaron L. Borjesson, Mats Corrado, Domenico Owens, David S. Patel, Akash Pelliccia, Antonio Vetter, Victoria L. Ackerman, Michael J. Anderson, Jeff Asplund, Chad A. Cannon, Bryan C. DiFiori, John Fischbach, Peter Froelicher, Victor Harmon, Kimberly G. Heidbuchel, Hein Marek, Joseph Paul, Stephen Prutkin, Jordan M. Salerno, Jack C. Schmied, Christian M. Sharma, Sanjay Stein, Ricardo Wilson, Mathew TI Abnormal electrocardiographic findings in athletes: recognising changes suggestive of cardiomyopathy SO BRITISH JOURNAL OF SPORTS MEDICINE LA English DT Article ID LEFT-VENTRICULAR NONCOMPACTION; PRIMARY PULMONARY-HYPERTENSION; BUNDLE-BRANCH BLOCK; DISTINGUISHING HYPERTROPHIC CARDIOMYOPATHY; CARDIOVASCULAR MAGNETIC-RESONANCE; FAMILIAL DILATED CARDIOMYOPATHY; ST-SEGMENT ELEVATION; SUDDEN-DEATH; NON-COMPACTION; SYSTOLIC DYSFUNCTION AB Cardiomyopathies are a heterogeneous group of heart muscle diseases and collectively are the leading cause of sudden cardiac death (SCD) in young athletes. The 12-lead ECG is utilised as both a screening and diagnostic tool for detecting conditions associated with SCD. Fundamental to the appropriate evaluation of athletes undergoing ECG is an understanding of the ECG findings that may indicate the presence of an underlying pathological cardiac disorder. This article describes ECG findings present in cardiomyopathies afflicting young athletes and outlines appropriate steps for further evaluation of these ECG abnormalities. The ECG findings defined as abnormal in athletes were established by an international consensus panel of experts in sports cardiology and sports medicine. C1 [Drezner, Jonathan A.; Harmon, Kimberly G.] Univ Washington, Dept Family Med, Seattle, WA 98195 USA. [Ashley, Euan; Froelicher, Victor] Stanford Univ, Sch Med, Div Cardiovasc Med, Palo Alto, CA 94304 USA. [Baggish, Aaron L.] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA. [Borjesson, Mats] Karolinska Univ Hosp, Swedish Sch Sports & Hlth Sci, Dept Cardiol, Stockholm, Sweden. [Corrado, Domenico] Univ Padua, Dept Cardiac Thorac & Vasc Sci, Padua, Italy. [Owens, David S.; Prutkin, Jordan M.] Univ Washington, Div Cardiol, Seattle, WA 98195 USA. [Patel, Akash; Vetter, Victoria L.] Childrens Hosp Philadelphia, Div Cardiol, Philadelphia, PA 19104 USA. [Pelliccia, Antonio] Inst Sport Med & Sci, Dept Med, Rome, Italy. [Ackerman, Michael J.] Mayo Clin, Dept Med, Rochester, MN USA. [Ackerman, Michael J.] Mayo Clin, Dept Pediat, Rochester, MN USA. [Ackerman, Michael J.] Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN USA. [Ackerman, Michael J.; Cannon, Bryan C.] Mayo Clin, Div Cardiovasc Dis, Rochester, MN USA. [Ackerman, Michael J.] Mayo Clin, Div Pediat Cardiol, Rochester, MN USA. [Anderson, Jeff] Univ Connecticut, Dept Athlet, Storrs, CT USA. [Asplund, Chad A.] Eisenhower Army Med Ctr, Dept Family Med, Ft Gordon, GA USA. [DiFiori, John] Univ Calif Los Angeles, Div Sports Med, Los Angeles, CA USA. [Fischbach, Peter] Emory Univ, Sch Med, Dept Pediat, Childrens Healthcare Atlanta, Atlanta, GA USA. [Heidbuchel, Hein] Univ Louvain, Dept Cardiovasc Sci, Louvain, Belgium. [Marek, Joseph] Midwest Heart Fdn, Oak Brook Terrace, IL USA. [Paul, Stephen] Univ Arizona, Dept Family & Community Med, Tucson, AZ USA. [Salerno, Jack C.] Seattle Childrens Hosp, Div Cardiol, Seattle, WA USA. [Schmied, Christian M.] Univ Zurich Hosp, Div Cardiol, CH-8091 Zurich, Switzerland. [Sharma, Sanjay] St Georges Univ London, Dept Cardiovasc Sci, London, England. [Stein, Ricardo] Hosp Clin Porto Alegre, Dept Cardiol, Porto Alegre, RS, Brazil. [Wilson, Mathew] Qatar Orthoped & Sports Med Hosp, ASPETAR, Dept Sports Med, Doha, Qatar. RP Drezner, JA (reprint author), Univ Washington, Dept Family Med, 1959 NE Pacific St,Box 356390, Seattle, WA 98195 USA. EM jdrezner@uw.edu OI Borjesson, Mats/0000-0002-8786-0438; Owens, David/0000-0002-7293-9688 NR 91 TC 46 Z9 46 U1 0 U2 22 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0306-3674 J9 BRIT J SPORT MED JI Br. J. Sports Med. PD FEB PY 2013 VL 47 IS 3 BP 137 EP + DI 10.1136/bjsports-2012-092069 PG 18 WC Sport Sciences SC Sport Sciences GA 081VE UT WOS:000314349700004 PM 23303760 ER PT J AU Drezner, JA Ackerman, MJ Cannon, BC Corrado, D Heidbuchel, H Prutkin, JM Salerno, JC Anderson, J Ashley, E Asplund, CA Baggish, AL Borjesson, M DiFiori, JP Fischbach, P Froelicher, V Harmon, KG Marek, J Owens, DS Paul, S Pelliccia, A Schmied, CM Sharma, S Stein, R Vetter, VL Wilson, MG AF Drezner, Jonathan A. Ackerman, Michael J. Cannon, Bryan C. Corrado, Domenico Heidbuchel, Hein Prutkin, Jordan M. Salerno, Jack C. Anderson, Jeffrey Ashley, Euan Asplund, Chad A. Baggish, Aaron L. Borjesson, Mats DiFiori, John P. Fischbach, Peter Froelicher, Victor Harmon, Kimberly G. Marek, Joseph Owens, David S. Paul, Stephen Pelliccia, Antonio Schmied, Christian M. Sharma, Sanjay Stein, Ricardo Vetter, Victoria L. Wilson, Mathew G. TI Abnormal electrocardiographic findings in athletes: recognising changes suggestive of primary electrical disease SO BRITISH JOURNAL OF SPORTS MEDICINE LA English DT Article ID LONG-QT-SYNDROME; PARKINSON-WHITE-SYNDROME; POLYMORPHIC VENTRICULAR-TACHYCARDIA; SUDDEN UNEXPLAINED DEATH; HEART-RHYTHM-SOCIETY; PROPOSED DIAGNOSTIC-CRITERIA; EXPERT CONSENSUS STATEMENT; OF-CARDIOLOGY FOUNDATION; BRUGADA-SYNDROME; CARDIAC DEATH AB Cardiac channelopathies are potentially lethal inherited arrhythmia syndromes and an important cause of sudden cardiac death (SCD) in young athletes. Other cardiac rhythm and conduction disturbances also may indicate the presence of an underlying cardiac disorder. The 12-lead ECG is utilised as both a screening and a diagnostic tool for detecting conditions associated with SCD. Fundamental to the appropriate evaluation of athletes undergoing ECG is an understanding of the ECG findings that may indicate the presence of a pathological cardiac disease. This article describes ECG findings present in primary electrical diseases afflicting young athletes and outlines appropriate steps for further evaluation of these ECG abnormalities. The ECG findings defined as abnormal in athletes were established by an international consensus panel of experts in sports cardiology and sports medicine. C1 [Drezner, Jonathan A.; Harmon, Kimberly G.] Univ Washington, Dept Family Med, Seattle, WA 98195 USA. [Ackerman, Michael J.] Mayo Clin, Dept Med, Rochester, MN USA. [Ackerman, Michael J.] Mayo Clin, Dept Pediat, Rochester, MN USA. [Ackerman, Michael J.] Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN USA. [Ackerman, Michael J.; Cannon, Bryan C.] Mayo Clin, Div Cardiovasc Dis, Rochester, MN USA. [Ackerman, Michael J.] Mayo Clin, Div Pediat Cardiol, Rochester, MN USA. [Corrado, Domenico] Univ Padua, Dept Cardiac Thorac & Vasc Sci, Padua, Italy. [Heidbuchel, Hein] Univ Louvain, Dept Cardiovasc Sci, Louvain, Belgium. [Prutkin, Jordan M.; Owens, David S.] Univ Washington, Div Cardiol, Seattle, WA 98195 USA. [Salerno, Jack C.] Seattle Childrens Hosp, Div Cardiol, Seattle, WA USA. [Anderson, Jeffrey] Univ Connecticut, Dept Athlet, Storrs, CT USA. [Ashley, Euan; Froelicher, Victor] Stanford Univ, Sch Med, Div Cardiovasc Med, Palo Alto, CA 94304 USA. [Asplund, Chad A.] Eisenhower Army Med Ctr, Dept Family Med, Ft Gordon, GA USA. [Baggish, Aaron L.] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA. [Borjesson, Mats] Karolinska Univ Hosp, Swedish Sch Sports & Hlth Sci, Stockholm, Sweden. [Borjesson, Mats] Karolinska Univ Hosp, Dept Cardiol, Stockholm, Sweden. [DiFiori, John P.] Univ Calif Los Angeles, Div Sports Med, Los Angeles, CA USA. [Fischbach, Peter] Emory Univ, Sch Med, Dept Pediat, Childrens Healthcare Atlanta, Atlanta, GA USA. [Marek, Joseph] Midwest Heart Fdn, Oak Brook Terrace, IL USA. [Paul, Stephen] Univ Arizona, Dept Family & Community Med, Tucson, AZ USA. [Pelliccia, Antonio] Inst Sport Med & Sci, Dept Med, Rome, Italy. [Schmied, Christian M.] Univ Zurich Hosp, Div Cardiol, CH-8091 Zurich, Switzerland. [Sharma, Sanjay] St Georges Univ London, Dept Cardiovasc Sci, London, England. [Stein, Ricardo] Hosp Clin Porto Alegre, Dept Cardiol, Porto Alegre, RS, Brazil. [Vetter, Victoria L.] Childrens Hosp Philadelphia, Div Cardiol, Philadelphia, PA 19104 USA. [Wilson, Mathew G.] Qatar Orthoped & Sports Med Hosp, ASPETAR, Dept Sports Med, Doha, Qatar. RP Drezner, JA (reprint author), Univ Washington, Dept Family Med, 1959 NE Pacific St,Box 356930, Seattle, WA 98195 USA. EM jdrezner@uw.edu OI Borjesson, Mats/0000-0002-8786-0438; Owens, David/0000-0002-7293-9688 NR 67 TC 42 Z9 43 U1 0 U2 14 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0306-3674 J9 BRIT J SPORT MED JI Br. J. Sports Med. PD FEB PY 2013 VL 47 IS 3 BP 153 EP + DI 10.1136/bjsports-2012-092070 PG 17 WC Sport Sciences SC Sport Sciences GA 081VE UT WOS:000314349700005 PM 23303761 ER PT J AU de Mel, G Sensoy, M Vasconcelos, W Norman, TJ AF de Mel, Geeth Sensoy, Murat Vasconcelos, Wamberto Norman, Timothy J. TI A hybrid reasoning mechanism for effective sensor selection for tasks SO ENGINEERING APPLICATIONS OF ARTIFICIAL INTELLIGENCE LA English DT Article DE Logic Programming; Semantic web; Knowledge-based resource selection ID OWL-DL; RULES; ASSIGNMENT AB In this paper, we present Ontological Logic Programming (OLP), a novel approach that combines logic programming with ontological reasoning. OLP enables the use of ontological terms (i.e., individuals, classes and properties) directly within logic programmes. The interpretation of these terms is delegated to an ontology reasoner during the interpretation of the programme. Unlike similar approaches, OLP makes use of the full capacity of both ontological reasoning and logic programming. We evaluate the computational properties of OLP in different settings and show that its performance can be significantly improved using caching mechanisms. We then introduce a comprehensive sensor-task selection solution based on OLP and discuss the benefits one can obtain by using OLP. The solution is based on a set of interlinking ontologies that capture the crucial domain knowledge of sensor networks. We then make use of OLP to create and manage complex concepts in the domain as well as to implement effective resource-task assignment algorithms, which compute appropriate resources for tasks such that they sufficiently cover the tasks needs. We compare the advantages of OLP with a knowledge-based set-covering mechanism for resource-task selection. (C) 2012 Elsevier Ltd. All rights reserved. C1 [de Mel, Geeth; Sensoy, Murat; Vasconcelos, Wamberto; Norman, Timothy J.] Univ Aberdeen, Dept Comp Sci, Aberdeen AB24 3UE, Scotland. [de Mel, Geeth] USA, Res Lab, Adelphi, MD 20783 USA. [de Mel, Geeth] IBM Corp, Thomas J Watson Res Ctr, Yorktown Hts, NY 10598 USA. [Sensoy, Murat] Ozyegin Univ, Dept Comp Sci, Istanbul, Turkey. RP de Mel, G (reprint author), IBM Corp, Thomas J Watson Res Ctr, Yorktown Hts, NY 10598 USA. EM grdemel@us.ibm.com; m.sensoy@abdn.ac.uk; w.w.vasconcelos@abdn.ac.uk; t.j.norman@abdn.ac.uk FU U.S. Army Research Laboratory [W911NF-06-3-0001]; U.K. Ministry of Defence [W911NF-06-3-0001] FX This research was sponsored by the U.S. Army Research Laboratory and the U.K. Ministry of Defence and was accomplished under Agreement Number W911NF-06-3-0001. The views and conclusions in this document are those of the author(s) and should not be interpreted as representing the official policies, either expressed or implied, of the U.S. Army Research Laboratory, the U.S. Government, the U.K. Ministry of Defence or the U.K. Government. The U.S. and U.K. Governments are authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. NR 39 TC 0 Z9 0 U1 1 U2 18 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0952-1976 J9 ENG APPL ARTIF INTEL JI Eng. Appl. Artif. Intell. PD FEB PY 2013 VL 26 IS 2 BP 873 EP 887 DI 10.1016/j.engappai.2012.12.003 PG 15 WC Automation & Control Systems; Computer Science, Artificial Intelligence; Engineering, Multidisciplinary; Engineering, Electrical & Electronic SC Automation & Control Systems; Computer Science; Engineering GA 086GP UT WOS:000314672400018 ER PT J AU Warr, BJ Scofield, DE Spiering, BA Alvar, BA AF Warr, Bradley J. Scofield, Dennis E. Spiering, Barry A. Alvar, Brent A. TI INFLUENCE OF TRAINING FREQUENCY ON FITNESS LEVELS AND PERCEIVED HEALTH STATUS IN DEPLOYED NATIONAL GUARD SOLDIERS SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE soldiers; deployment; training frequency; perceived health; fitness ID PHYSICAL-FITNESS; BODY-COMPOSITION AB Warr BJ, Scofield DE, Spiering BA, and Alvar BA. Influence of training frequency on fitness levels and perceived health status in deployed National Guard Soldiers. J Strength Cond Res 27 (2): 315-322, 2013-While studies have examined changes in body composition, fitness, and other measures pre- and post-deployment, it is more difficult to characterize physical training practices during deployment. The purpose of this study was to evaluate the association between training frequency during deployment and changes in physical performance, body composition, and perceived health. Eighty-eight Soldiers (men, 76 and women, 12) from the National Guard performed 1 repetition maximum (1RM) bench press, 1RM back squat, and (V) over dotO(2)peak testing within 30 days before and 10 days after deployment to Iraq or Afghanistan. Soldiers completed a questionnaire pertaining to aerobic and strength training frequency, as well as perceived changes to health. Soldiers experienced significant (p <= 0.05) improvements in upper (11%) and lower body strength (14%), declines in body fat percent (-16%), but no change in (V) over dotO(2)peak. About 57% of Soldiers reportedly performed aerobic training >= 3 times per week, whereas 67% performed strength training >= 3 times per week. Soldiers performing aerobic training >= 3 times per week responded differently than those who conducted aerobic training <3 times per week in (V) over dotO(2)peak values (2 vs. -8%, p = 0.016). About 42% of Soldiers reported that their health improved, 36% reported no change to their health, and 22% reported that their health had declined. There was a significant association between training frequency and perceived health. About 50-58% of Soldiers who trained >= 3 times per week reported improvements in health during deployment, whereas only 21-24% of Soldiers who trained <3 times per week reported improvements in health for the same period of time. It seems that Soldiers who train >= 3 times per week experience a more advantageous response in terms of fitness levels and perceived health during deployments. C1 [Warr, Bradley J.; Scofield, Dennis E.; Spiering, Barry A.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Alvar, Brent A.] Rocky Mt Univ Hlth Profess, Provo, UT USA. RP Warr, BJ (reprint author), USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. EM bradley.warr@us.army.mil RI SCOFIELD, DENNIS/F-3636-2015 FU Arizona National Guard; American College of Sports Medicine; United States Army Research Institute of Environmental Medicine FX The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Army or the Department of Defense. The authors thank the Arizona National Guard for their support and participation in this study. The authors have no conflicts of interest related to the contents of this manuscript. This study was financially supported by a Doctoral Student Research Grant from the American College of Sports Medicine and the United States Army Research Institute of Environmental Medicine. NR 15 TC 2 Z9 2 U1 0 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1064-8011 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD FEB PY 2013 VL 27 IS 2 BP 315 EP 322 PG 8 WC Sport Sciences SC Sport Sciences GA 086WB UT WOS:000314718600006 PM 23222077 ER PT J AU Manfredi, TG Monteiro, MA Lamont, LS Singh, MF Foldvari, M White, S Cosmas, AC Urso, ML AF Manfredi, Thomas G. Monteiro, Michael A. Lamont, Linda S. Singh, Maria F. Foldvari, Mona White, Sebrina Cosmas, Arthur C. Urso, Maria L. TI POSTMENOPAUSAL EFFECTS OF RESISTANCE TRAINING ON MUSCLE DAMAGE AND MITOCHONDRIA SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE aging; exercise training; strength; muscle adaptation ID SKELETAL-MUSCLE; OXIDATIVE STRESS; ENZYME-ACTIVITY; HEART-FAILURE; FRAIL ELDERS; OLDER MEN; EXERCISE; WOMEN; STRENGTH; DISEASE AB Manfredi, TG, Monteiro, MA, Lamont, LS, Singh, MF, Foldvari, M, White, S, Cosmas, AC, and Urso, ML. Postmenopausal effects of resistance training on muscle damage and mitochondria. J Strength Cond Res 27(2): 556-561, 2013-The purpose of this study was to measure the effects of a 12-month progressive resistance training intervention on muscle morphology and strength gains in postmenopausal women. Skeletal muscle biopsies were obtained from the vastus lateralis of 5 independent community-dwelling women (mean age: 75.6 +/- 4.28 years; mean height: 163 +/- 5.34 cm; mean weight: 72 +/- 17.5 kg) before 6 months and 12 months after progressive resistance training. Muscle strength (1 repetition maximum) was measured at the same time points. After 6 months of training, morphological analysis revealed evidence of increased proteolysis and tissue repair, and rudimentary fiber development. The percent of Z-bands with mild Z-band disruption increased from 43.9% at baseline to 66.7% after 6 months of training (p < 0.01). Mitochondrial volume also increased (percent of mitochondria = 0.86% at baseline, 1.19% at 6 months, and 1.04% at 12 months, p < 0.05), and there was a shift to larger sized mitochondria. The training did not result in statistically significant increases in muscle leg strength (p < 0.18). It appears that mild Z-band disruption acts as a precursor for increased protein synthesis and stimulates an increase in mitochondrial mass. Therefore, although a progressive resistance training program in this population did not increase muscle strength, it did demonstrate clinical applications that lend support to the importance of resistance training in older adults. C1 [Manfredi, Thomas G.; Monteiro, Michael A.; Lamont, Linda S.; White, Sebrina; Cosmas, Arthur C.] Univ Rhode Isl, Energy Metab Lab, Kingston, RI 02881 USA. [Manfredi, Thomas G.; Monteiro, Michael A.; Lamont, Linda S.; White, Sebrina; Cosmas, Arthur C.] Univ Rhode Isl, Dept Kinesiol, Kingston, RI 02881 USA. [Singh, Maria F.; Foldvari, Mona] Tufts Univ, Nutr Exercise Physiol & Sarcopenia Lab, Jean Mayer USDA, Human Nutr Res Ctr Aging, Boston, MA 02111 USA. [Singh, Maria F.] Univ Sydney, Sch Exercise & Sport Sci, Lidcombe, NSW, Australia. [Cosmas, Arthur C.] Select Med Sports Med & Outpatient Rehabil, Hartford, CT USA. [Urso, Maria L.] USA, Mil Performance Div, Inst Environm Med USARIEM, Natick, MA 01760 USA. RP Urso, ML (reprint author), USA, Mil Performance Div, Inst Environm Med USARIEM, Natick, MA 01760 USA. EM maria.urso@us.army.mil FU National Institutes of Health, Institute of General Medical Sciences, Bridges to the Future [R25 GM51780-02]; University of Rhode Island FX M. Monteiro was supported by a grant from the National Institutes of Health, Institute of General Medical Sciences, Bridges to the Future Grant R25 GM51780-02 awarded to the Kinesiology department (L. S. Lamont), University of Rhode Island. Disclaimer: The opinions or assertions contained herein are the private views of the author(s) and are not to be construed as official or as reflecting the views of the Army or the Department of Defense. NR 29 TC 1 Z9 1 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1064-8011 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD FEB PY 2013 VL 27 IS 2 BP 556 EP 561 PG 6 WC Sport Sciences SC Sport Sciences GA 086WB UT WOS:000314718600037 PM 23090317 ER PT J AU Goldman, GH AF Goldman, Geoffrey H. TI Doppler-based motion compensation algorithm for focusing the signature of a rotorcraft SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID TRACKING; AIRCRAFT; SENSOR AB A computationally efficient algorithm was developed and tested to compensate for the effects of motion on the acoustic signature of a rotorcraft. For target signatures with large spectral peaks that vary slowly in amplitude and have near constant frequency, the time-varying Doppler shift can be tracked and then removed from the data. The algorithm can be used to preprocess data for classification, tracking, and nulling algorithms. The algorithm was tested on rotorcraft data. The average instantaneous frequency of the first harmonic of a rotorcraft was tracked with a fixed-lag smoother. Then, state space estimates of the frequency were used to calculate a time warping that removed the effect of a time-varying Doppler shift from the data. The algorithm was evaluated by analyzing the increase in the amplitude of the harmonics in the spectrum of a rotorcraft. The results depended upon the frequency of the harmonics and the processing interval duration. Under good conditions, the results for the fundamental frequency of the target (similar to 11 Hz) almost achieved an estimated upper bound. The results for higher frequency harmonics had larger increases in the amplitude of the peaks, but significantly lower than the estimated upper bounds. [http://dx.doi.org/10.1121/1.4773273] C1 USA, Res Lab, ATTN RDRL SES P, Adelphi, MD 20783 USA. RP Goldman, GH (reprint author), USA, Res Lab, ATTN RDRL SES P, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM geoffrey.h.goldman.civ@mail.mil NR 28 TC 1 Z9 1 U1 0 U2 7 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD FEB PY 2013 VL 133 IS 2 BP 688 EP 696 DI 10.1121/1.4773273 PG 9 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 080TW UT WOS:000314267200018 PM 23363088 ER PT J AU Pollard, KA Tran, PK Letowski, TR AF Pollard, Kimberly A. Tran, Phuong K. Letowski, Tomasz R. TI A free-field method to calibrate bone conduction transducers SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID ACQUISITION TEST CAT; SPEECH-INTELLIGIBILITY; HEARING PROTECTOR; BACKGROUND-NOISE; VIBRATORS; EAR; EARPHONES; SOUND; TRANSMISSION; CANCELLATION AB Bone conduction communication systems employ a variety of transducers with different physical and electroacoustic properties, and these transducers may be worn at various skull locations. Testing these systems thus requires a reliable means of transducer calibration that can be implemented across different devices, skull locations, and settings. Unfortunately, existing calibration standards do not meet these criteria. Audiometric bone conduction standards focus on only one device model and on limited skull locations. Furthermore, while mechanical couplers may be used for calibration, the general human validity of their results is suspect. To address the need for more flexible, human-centered calibration methods, the authors investigated a procedure for bone transducer calibration, analogous to free-field methods for calibrating air conduction headphones. Participants listened to1s third-octave noise bands (125-12 500 Hz) alternating between a bone transducer and a loudspeaker and adjusted the bone transducer to match the perceived loudness of the loudspeaker at each test frequency. Participants tested two transducer models and two skull locations. Intra-and inter-subject reliability was high, and the resulting data differed by transducer, by location, and from the mechanical coupler. The described procedure is flexible to transducer model and skull location, requires only basic equipment, and directly yields perceptual data. [http://dx.doi.org/10.1121/1.4774273] C1 [Pollard, Kimberly A.; Tran, Phuong K.; Letowski, Tomasz R.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Pollard, KA (reprint author), USA, Res Lab, 520 Mulberry Point Rd, Aberdeen Proving Ground, MD 21005 USA. EM kpollard@ucla.edu FU Oak Ridge Associated Universities postdoctoral fellowship FX The authors would like to thank all our subjects for participating in this research. We also thank Paula Henry and Ashley Foots of ARL for advice and for performing hearing tests on our participants, Walter Piroth of Sensory Devices for advice and assistance during the study, and Diana Emanuel of Towson University for allowing us to use their mechanical coupler. This research was conducted under an Oak Ridge Associated Universities postdoctoral fellowship to KAP. NR 50 TC 3 Z9 3 U1 0 U2 15 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD FEB PY 2013 VL 133 IS 2 BP 858 EP 865 DI 10.1121/1.4774273 PG 8 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 080TW UT WOS:000314267200034 PM 23363104 ER PT J AU Corona, BT Ingalls, CP AF Corona, Benjamin T. Ingalls, Christopher P. TI Immediate force loss after eccentric contractions is increased with l-name administration, a nitric oxide synthase inhibitor SO MUSCLE & NERVE LA English DT Article DE eccentric contractions; force; L-NAME; muscle injury; nitric oxide synthase ID SKELETAL-MUSCLE CELLS; MOUSE SOLEUS MUSCLE; INDUCED INJURY; COUPLING FAILURE; EDL MUSCLE; EXERCISE; CALCIUM; STRETCH; DAMAGE AB Introduction Nitric oxide (NO) signaling regulates many biological processes in skeletal muscle, wherein aberrant signaling contributes to myopathic conditions (e.g., Duchenne muscular dystrophy). NO has been shown to play a role in muscle regeneration after injury. However, less is known about its role during injury. In this study we aimed to determine whether NO synthase (NOS) inhibition exacerbates functional deficits immediately after the performance of eccentric contractions. Methods Wild-type mouse extensor digitorum longus (EDL) muscles underwent in vitro functional testing in the presence or absence of a non-specific NOS inhibitor (L-NAME, 10 mM) before and after performance of 10 eccentric contractions. Results After eccentric contractions, Po was reduced by ?25% for muscle in regular physiological solution but by ?50% with the addition of L-NAME (P = 0.009). Conclusions Non-specific blockade of NOS exacerbates functional deficits immediately after eccentric contractions, suggesting that NO signaling protects skeletal muscle from excessive injury in healthy muscle. Muscle Nerve 47: 271-273, 2013 C1 [Corona, Benjamin T.; Ingalls, Christopher P.] Georgia State Univ, Muscle Biol Lab, Dept Kinesiol & Hlth, Atlanta, GA 30303 USA. RP Corona, BT (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM benjamin.t.corona.ctr@us.army.mil FU National Institute of Arthritis and Musculoskeletal and Skin Diseases [AR-41802] FX Supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases Grant AR-41802. NR 25 TC 1 Z9 3 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0148-639X J9 MUSCLE NERVE JI Muscle Nerve PD FEB PY 2013 VL 47 IS 2 BP 271 EP 273 DI 10.1002/mus.23655 PG 3 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 078VS UT WOS:000314128700016 PM 23349083 ER PT J AU Streeck, H D'Souza, MP Littman, DR Crotty, S AF Streeck, Hendrik D'Souza, M. Patricia Littman, Dan R. Crotty, Shane TI Harnessing CD4(+) T cell responses in HIV vaccine development SO NATURE MEDICINE LA English DT Article ID SIMIAN IMMUNODEFICIENCY VIRUS; FOLLICULAR HELPER-CELLS; CHRONIC VIRAL-INFECTION; MEMORY B-CELLS; GERMINAL CENTER FORMATION; LIVED PLASMA-CELLS; NEUTRALIZING ANTIBODIES; SIV INFECTION; CUTTING EDGE; POTENT NEUTRALIZATION AB CD4(+) T cells can perform a panoply of tasks to shape an effective response against a pathogen. Limited attention has been paid to the potential importance of functional CD4(+) T cell responses in the context of the development of next-generation vaccines, including HIV vaccines. Many CD4(+) T cell functions are newly appreciated and only partially understood. A workshop was held as a forum to bring together a small group of experts to exchange ideas on the role of CD4(+) T cells in developing durable functional antibody responses, via follicular helper T cells, as well as on the roles of CD4(+) T cells in other aspects of protective immunity. Here we discuss whether CD4(+) T cell responses may represent a beneficial component of an efficacious HIV vaccine. C1 [Streeck, Hendrik] Walter Reed Army Inst Res, Henry M Jackson Fdn, US Mil HIV Res Program, Silver Spring, MD USA. [D'Souza, M. Patricia] US Natl Inst Allergy & Infect Dis, Vaccine Clin Res Branch, Div Aids, Bethesda, MD USA. [Littman, Dan R.] New York Univ Sch Med, Kimmel Ctr Biol & Med, Skirball Inst, Mol Pathogenesis Program, New York, NY USA. [Littman, Dan R.] New York Univ Sch Med, Howard Hughes Med Inst, New York, NY USA. [Crotty, Shane] La Jolla Inst Allergy & Immunol, Div Vaccine Discovery, La Jolla, CA USA. [Crotty, Shane] Univ Calif San Diego Sch Med, Dept Med, La Jolla, CA USA. [Crotty, Shane] Ctr HIV AIDS Vaccine Immunol & Immunogen Discover, La Jolla, CA USA. RP Streeck, H (reprint author), Walter Reed Army Inst Res, Henry M Jackson Fdn, US Mil HIV Res Program, Silver Spring, MD USA. EM hstreeck@hivresearch.org; shane@liai.org FU Division of AIDS of the National Institute of Allergy and Infectious Diseases of the US National Institutes of Health (NIH); Ragon Institute; Center for HIV/AIDS Immunology and Immunogen Discovery; NIH [U19AI090970, P01AI096187]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; US Department of Defense; [R01AI094602-01]; [R01 AI091450-01] FX The organizers thank all of the workshop speakers and participants. The speakers were R. Amara, D. Brooks, M. Cancro, S.C., A. Iwasaki, J. Kolls, R. Koup, D.R.L., J. Mascola, H.S., J. Wherry and E. Zuniga. This work was supported by the Division of AIDS of the National Institute of Allergy and Infectious Diseases of the US National Institutes of Health (NIH) and the Ragon Institute. S.C. was supported by the Center for HIV/AIDS Immunology and Immunogen Discovery and NIH U19AI090970 and NIH P01AI096187. H.S. is supported by R01AI094602-01, R01 AI091450-01 and by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the US Department of Defense. NR 99 TC 49 Z9 50 U1 1 U2 29 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1078-8956 J9 NAT MED JI Nat. Med. PD FEB PY 2013 VL 19 IS 2 BP 143 EP 149 DI 10.1038/nm.3054 PG 7 WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental Medicine GA 086HY UT WOS:000314675900022 PM 23389614 ER PT J AU Stone, MC Chen, L Mckay, SK Goreham, J Acharya, K Fischenich, C Stone, AB AF Stone, Mark C. Chen, Li Mckay, S. Kyle Goreham, John Acharya, Kumud Fischenich, Craig Stone, Asako B. TI BENDING OF SUBMERGED WOODY RIPARIAN VEGETATION AS A FUNCTION OF HYDRAULIC FLOW CONDITIONS SO RIVER RESEARCH AND APPLICATIONS LA English DT Article DE riparian vegetation; hydraulic roughness; flood hydraulics; stream restoration; arid hydrology ID WIND-TUNNEL MEASUREMENTS; FLEXIBLE VEGETATION; DRAG RELATIONSHIPS; CONIFEROUS TREES; CHANNEL LININGS; RESISTANCE; STREAMS; GRASS AB Woody riparian vegetation provides numerous ecological benefits such as stabilizing streambanks, storing and cycling nutrients, shading streams and providing habitat for wildlife. However, vegetation also increases hydraulic roughness and reduces the effective flow area, resulting in an increased water surface elevation for a given streamflow. Balancing the desire to preserve woody vegetation in stream corridors with the need to manage flood risks requires accurate techniques for predicting the influence of vegetation on stream hydraulics. However, this is a challenging problem because woody vegetation responds to the flow field itself by bending and streamlining in response to hydraulic forces. The goal of this study was to predict the bending behaviour of woody riparian vegetation as a function of hydraulic flow conditions. Field tests were performed to elucidate tree biomechanical properties for select riparian taxa of the southwestern USA. Biomechanical results served as input parameters for a numerical algorithm designed to predict tree bending for water velocities likely to be encountered during flood events. Bending simulations revealed appreciable variability in bent tree heights. Variability was likely a manifestation of the extensive variance in plant characteristics and properties inherent in biological specimens. However, no trees were expected to bend to a height lower than approximately 42% of their original height, even in water moving at 2.5m center dot s-1. The results of this work provide an important first step in an effort to predict a dynamic hydraulic roughness for vegetated channels and floodplains under flood conditions. Copyright (c) 2011 John Wiley & Sons, Ltd. C1 [Stone, Mark C.] Univ New Mexico, Dept Civil Engn, Albuquerque, NM 87131 USA. [Chen, Li; Acharya, Kumud] Desert Res Inst, Div Hydrol Sci, Las Vegas, NV USA. [Mckay, S. Kyle] USA, Corps Engineers, Engn Res & Dev Ctr, Athens, GA USA. [Goreham, John] Matson & Associates, State Coll, PA USA. [Fischenich, Craig] USA, Corps Engineers, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Stone, Asako B.] Cent New Mexico Community Coll, Albuquerque, NM USA. RP Stone, MC (reprint author), Univ New Mexico, Dept Civil Engn, Albuquerque, NM 87131 USA. EM stone@unm.edu RI Chen, Li/E-3771-2013 OI Chen, Li/0000-0001-9131-1688 NR 36 TC 11 Z9 11 U1 1 U2 44 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1535-1459 J9 RIVER RES APPL JI River Res. Appl. PD FEB PY 2013 VL 29 IS 2 BP 195 EP 205 DI 10.1002/rra.1592 PG 11 WC Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA 086UI UT WOS:000314712700006 ER PT J AU Tretyakova, I Lukashevich, IS Glass, P Wang, EY Weaver, S Pushko, P AF Tretyakova, Irina Lukashevich, Igor S. Glass, Pamela Wang, Eryu Weaver, Scott Pushko, Peter TI Novel vaccine against Venezuelan equine encephalitis combines advantages of DNA immunization and a live attenuated vaccine SO VACCINE LA English DT Article DE DNA vaccine; Live attenuated virus; Infectious DNA; Venezuelan equine encephalitis; VEE; TC-83 ID CULEX MELANOCONION TAENIOPUS; E2 ENVELOPE GLYCOPROTEIN; VIRUS SUBTYPE IAB; NEUTRALIZING ANTIBODIES; ENCEPHALOMYELITIS VIRUS; AEROSOL CHALLENGE; NONHUMAN-PRIMATES; VECTOR COMPETENCE; IMMUNOGENICITY; EFFICACY AB DNA vaccines combine remarkable genetic and chemical stability with proven safety and efficacy in animal models, while remaining less immunogenic in humans. In contrast, live-attenuated vaccines have the advantage of inducing rapid, robust, long-term immunity after a single-dose vaccination. Here we describe novel iDNA vaccine technology that is based on an infectious DNA platform and combines advantages of DNA and live attenuated vaccines. We applied this technology for vaccination against infection with Venezuelan equine encephalitis virus (VEEV), an alphavirus from the Togaviridae family. The iDNA vaccine is based on transcription of the full-length genomic RNA of the TC-83 live-attenuated virus from plasmid DNA in vivo. The in vivo-generated viral RNA initiates limited replication of the vaccine virus, which in turn leads to efficient immunization. This technology allows the plasmid DNA to launch a live-attenuated vaccine in vitro or in vivo. Less than 10 ng of pTC83 iDNA encoding the full-length genomic RNA of the TC-83 vaccine strain initiated replication of the vaccine virus in vitro. In order to evaluate this approach in vivo, BALB/c mice were vaccinated with a single dose of pTC83 iDNA. After vaccination, all mice seroconverted with no adverse reactions. Four weeks after immunization, animals were challenged with the lethal epidemic strain of VEEV. All iDNA-vaccinated mice were protected from fatal disease, while all unvaccinated controls succumbed to infection and died. To our knowledge, this is the first example of launching a clinical live-attenuated vaccine from recombinant plasmid DNA in vivo. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Tretyakova, Irina; Pushko, Peter] Medigen Inc, Frederick, MD 21704 USA. [Lukashevich, Igor S.] Univ Louisville, Louisville, KY 40202 USA. [Glass, Pamela] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Wang, Eryu; Weaver, Scott] Univ Texas Med Branch, Inst Human Infect & Immun, Sealy Ctr Vaccine Dev, GNL, Galveston, TX 77555 USA. [Wang, Eryu; Weaver, Scott] Univ Texas Med Branch, Dept Pathol, GNL, Galveston, TX 77555 USA. RP Pushko, P (reprint author), Medigen Inc, 4539 Metropolitan Court, Frederick, MD 21704 USA. EM ppushko@medigen-usa.com FU National Institute of Allergy and Infectious Diseases of the National Institutes of Health [R43AI094863] FX Authors thank Michael Parker, Elena Klyushnenkova, Marco Goicochea, Ruth Florese, Rachmat Hidajat, Brian Nickols, Jason Hearn, and Noble Life Sciences Inc. for their contributions to this study. The authors declare that they have no competing financial interests. Research reported in this publication was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under Award Number R43AI094863. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agency. NR 52 TC 17 Z9 18 U1 1 U2 21 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD FEB PY 2013 VL 31 IS 7 BP 1019 EP 1025 DI 10.1016/j.vaccine.2012.12.050 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 083TA UT WOS:000314486900003 PM 23287629 ER PT J AU Kaldy, JE Shafer, DJ AF Kaldy, James E. Shafer, Deborah J. TI Effects of salinity on survival of the exotic seagrass Zostera japonica subjected to extreme high temperature stress SO BOTANICA MARINA LA English DT Article DE mortality; non-indigenous seagrass; thermal threshold; Zostera japonica ID CLIMATE-CHANGE; INTRODUCED SEAGRASS; HALOPHILA-OVALIS; NORTH-AMERICA; BAY; USA; ECOSYSTEMS; ESTUARY; LIGHT; WASHINGTON AB Zostera japonica is a non-indigenous seagrass that is expanding along the Pacific Coast of North America. The ecophysiology of this seagrass is poorly studied and management of the species is fragmented. This split-plot mesocosm experiment was designed to evaluate the response of Z. japonica to chronic, extreme temperature and salinity stress to facilitate development of models to predict potential Z. japonica colonization. We collected Z. japonica plants from Padilla Bay, Washington and Yaquina Bay and Coos Bay, Oregon and exposed them to a constant water temperature of 15 degrees C or 35 degrees C at three different salinities (5, 20 and 35). After 7 days exposure, shoot survival ranged between 6% and 42%; after 9 days exposure, only a few plants from the Yaquina Bay population survived. At a ambient temperature (15 degrees C), no differences were detected among the three salinity treatments. However, at a temperature of 35 degrees C, the survival of plants grown at a salinity of 5 was significantly lower than at higher salinities (20 and 35). Although the effect of population was weak, the northern population appeared to be more susceptible to the combined effects of heat stress and low salinity than the southern populations. We suggest that Z. japonica will continue to spread southward along the Pacific coast of North America until it reaches systems that regularly exceed the temperature tolerances of this non-indigenous seagrass. C1 [Kaldy, James E.] US EPA, Western Ecol Div, Newport, OR 97365 USA. [Shafer, Deborah J.] USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Kaldy, JE (reprint author), US EPA, Western Ecol Div, 2111 SE Marine Sci Dr, Newport, OR 97365 USA. EM kaldy.jim@epa.gov NR 47 TC 5 Z9 5 U1 5 U2 64 PU WALTER DE GRUYTER & CO PI BERLIN PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY SN 0006-8055 J9 BOT MAR JI Bot. Marina PD FEB PY 2013 VL 56 IS 1 BP 75 EP 82 DI 10.1515/bot-2012-0144 PG 8 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA 081XY UT WOS:000314357200008 ER PT J AU Zhivov, A Liesen, RJ Richter, S Jank, R Underwood, DM Neth, D Woody, A Bjork, C AF Zhivov, Alexander Liesen, Richard J. Richter, Stephan Jank, Reinhard Underwood, David M. Neth, Dieter Woody, Alfred Bjork, Curt TI Energy performance optimization for Army installations SO BUILDING SERVICES ENGINEERING RESEARCH & TECHNOLOGY LA English DT Article DE Energy performance; energy optimization; army installation; building cluster; renewable energy; building renovation AB Buildings contribute to a large fraction of energy usage worldwide. In the United States alone, buildings consume about 40% of total energy expenditure, including 71% of electricity and 54% of natural gas.(1) The Army alone spends more than US $1 billion for building-related energy expenses. The 2005 Energy Policy Act(2) requires that Federal facilities be built to achieve at least a 30% energy savings over the 2004 International Energy Code or ASHRAE Standard 90.1-2004, as appropriate, and that energy efficient designs must be life-cycle cost effective. According to the Energy Independence and Security Act (EISA 2007),(3) new buildings and buildings undergoing major renovations shall be designed to reduce consumption of energy generated off-site or on-site using fossil fuels, as compared with such energy consumption by a similar building in fiscal year 2003 (FY03) as measured by Commercial Buildings Energy Consumption Survey (CBECS) or Residential Energy Consumption Survey (RECS) data from the Energy Information Agency, by 55% in 2010, 80% by 2020, and 100% by 2030. Current US research efforts focus on renewable energy sources and single-building energy efficiency, and pay little attention to integration and minimization of energy use in building communities, i.e. Army installations and university campuses. There is no over arching 'power delivery/energy storage/demand' architecture and methodology to accomplish this. C1 [Zhivov, Alexander; Liesen, Richard J.; Underwood, David M.] USA, Engineer Res & Dev Ctr, Champaign, IL 61824 USA. RP Zhivov, A (reprint author), USA, Engineer Res & Dev Ctr, Champaign, IL 61824 USA. EM Alexander.M.Zhivov@usace.army.mil FU Installation Management Command (IMCOM); US Army Corps of Engineers FX Funding for this research was provided by the Installation Management Command (IMCOM) and the US Army Corps of Engineers. NR 18 TC 0 Z9 0 U1 0 U2 13 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0143-6244 J9 BUILD SERV ENG RES T JI Build Serv. Eng. Res. Technol. PD FEB PY 2013 VL 34 IS 1 SI SI BP 87 EP 101 DI 10.1177/0143624412462907 PG 15 WC Construction & Building Technology SC Construction & Building Technology GA 077ZE UT WOS:000314067100007 ER PT J AU Brocato, RL Josleyn, MJ Wahl-Jensen, V Schmaljohn, CS Hooper, JW AF Brocato, R. L. Josleyn, M. J. Wahl-Jensen, V. Schmaljohn, C. S. Hooper, J. W. TI Construction and Nonclinical Testing of a Puumala Virus Synthetic M Gene-Based DNA Vaccine SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID NEUTRALIZING ANTIBODY-RESPONSE; HANTAVIRUS PULMONARY SYNDROME; ANDES VIRUS; HANTAAN-VIRUS; CYNOMOLGUS MACAQUES; HEMORRHAGIC-FEVER; PROTECTS HAMSTERS; NEPHROPATHIA-EPIDEMICA; NUCLEOCAPSID PROTEINS; NONHUMAN-PRIMATES AB Puumala virus (PUUV) is a causative agent of hemorrhagic fever with renal syndrome (HFRS). Although PUUV-associated HFRS does not result in high case-fatality rates, the social and economic impact is considerable. There is no licensed vaccine or specific therapeutic to prevent or treat HFRS. Here we report the synthesis of a codon-optimized, full-lengthMsegment open reading frame and its cloning into a DNA vaccine vector to produce the plasmid pWRG/PUU-M(s2). pWRG/PUU-M(s2) delivered by gene gun produced high-titer neutralizing antibodies in hamsters and nonhuman primates. Vaccination with pWRG/ PUU-M(s2) protected hamsters against infection with PUUV but not against infection by related HFRS-associated hantaviruses. Unexpectedly, vaccination protected hamsters in a lethal disease model of Andes virus (ANDV) in the absence of ANDV cross-neutralizing antibodies. This is the first evidence that an experimental DNA vaccine for HFRS can provide protection in a hantavirus lethal disease model. C1 [Brocato, R. L.; Josleyn, M. J.; Wahl-Jensen, V.; Hooper, J. W.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Wahl-Jensen, V.] NIAID, Integrated Res Facil Ft Detrick, Div Clin Res, NIH, Ft Detrick, MD USA. RP Hooper, JW (reprint author), USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. EM Jay.Hooper@amedd.army.mil OI Hooper, Jay/0000-0002-4475-0415 FU Military Infectious Disease Research Program (MIDRP); NIAID [HHSN272200200016I] FX This work was funded by the Military Infectious Disease Research Program (MIDRP), Program Area T. R. L. B. and V.W.-J. performed this work as participants in the National Research Council Associate Program. V.W.-J. also performed part of this work as an employee of Tunnell Consulting, Inc., a subcontractor to Battelle Memorial Institute under its prime contract with NIAID, under contract HHSN272200200016I. NR 45 TC 13 Z9 13 U1 1 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 EI 1556-679X J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD FEB PY 2013 VL 20 IS 2 BP 218 EP 226 DI 10.1128/CVI.00546-12 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 079JI UT WOS:000314166000013 PM 23239797 ER PT J AU Porter, CK Thura, N Ranallo, RT Riddle, MS AF Porter, C. K. Thura, N. Ranallo, R. T. Riddle, M. S. TI The Shigella human challenge model SO EPIDEMIOLOGY AND INFECTION LA English DT Review DE Gastrointestinal infections; Shigella; travellers' infection ID IRRITABLE-BOWEL-SYNDROME; FLEXNERI 2A; CLINICAL-TRIALS; SONNEI VACCINE; INFECTION; METAANALYSIS; VOLUNTEERS; EFFICACY; IMMUNOGENICITY; IMMUNIZATION AB Shigella is an important bacterial cause of infectious diarrhoea globally. The Shigella human challenge model has been used since 1946 for a variety of objectives including understanding disease pathogenesis, human immune responses and allowing for an early assessment of vaccine efficacy. A systematic review of the literature regarding experimental shigellosis in human subjects was conducted. Summative estimates were calculated by strain and dose. While a total of 19 studies evaluating nine strains at doses ranging from 10 to 1 x 10(10) colony-founing units were identified, most studies utilized the S. sonnei strain 53G and the S. flexneri strain 2457T. Inoculum solution and pre-inoculation buffering has varied over time although diarrhoea attack rates do not appear to increase above 75-80%, and dysentery rates remain fairly constant, highlighting the need for additional dose-ranging studies. Expansion of the model to include additional strains from different serotypes will elucidate serotype and strain-specific outcome variability. C1 [Porter, C. K.] USN, Enter Dis Dept, Infect Dis Directorate, Med Res Ctr, Silver Spring, MD 20910 USA. [Ranallo, R. T.] Walter Reed Army Inst Res, Dept Live Attenuated Shigella Vaccines, Bacterial Dis Branch, Silver Spring, MD USA. RP Porter, CK (reprint author), USN, Enter Dis Dept, Infect Dis Directorate, Med Res Ctr, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM chad.porter@med.navy.mil FU Military Infectious Disease Research Program funding FX This study was conducted under support of Military Infectious Disease Research Program funding. The opinions and assertions herein should not be construed as official or representing the views of the Department of the Navy, Department of the Army, the Department of Defense, or the U.S. Government. This is a U.S. Government work. There are no restrictions on its use. NR 32 TC 6 Z9 7 U1 1 U2 25 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0950-2688 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD FEB PY 2013 VL 141 IS 2 BP 223 EP 232 DI 10.1017/S0950268812001677 PG 10 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 077FN UT WOS:000314013400001 PM 22906296 ER PT J AU Gurram, P Kwon, H AF Gurram, Prudhvi Kwon, Heesung TI Sparse Kernel-Based Ensemble Learning With Fully Optimized Kernel Parameters for Hyperspectral Classification Problems SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE Chemical plume detection; ensemble learning; kernel parameter optimization; sparse kernel learning; support vector machine (SVM) ID SUPPORT VECTOR MACHINES; PATTERN-RECOGNITION AB Recently, a kernel-based ensemble learning technique for hyperspectral detection/classification problems has been introduced by the authors, to provide robust classification over hyperspectral data with relatively high level of noise and background clutter. The kernel-based ensemble technique first randomly selects spectral feature subspaces from the input data. Each individual classifier, which is in fact a support vector machine (SVM), then independently conducts its own learning within its corresponding spectral feature subspace and hence constitutes a weak classifier. The decisions from these weak classifiers are equally or adaptively combined to generate the final ensemble decision. However, in such ensemble learning, little attempt has been previously made to jointly optimize the weak classifiers and the aggregating process for combining the subdecisions. The main goal of this paper is to achieve an optimal sparse combination of the subdecisions by jointly optimizing the separating hyperplane obtained by optimally combining the kernel matrices of the SVM classifiers and the corresponding weights of the subdecisions required for the aggregation process. Sparsity is induced by applying an l1 norm constraint on the weighting coefficients. Consequently, the weights of most of the subclassifiers become zero after the optimization, and only a few of the subclassifiers with non-zero weights contribute to the final ensemble decision. Moreover, in this paper, an algorithm to determine the optimal full-diagonal bandwidth parameters of the Gaussian kernels of the individual SVMs is also presented by minimizing the radius-margin bound. The optimized full-diagonal bandwidth Gaussian kernels are used by the sparse SVM ensemble to perform binary classification. The performance of the proposed technique with optimized kernel parameters is compared to that of the one with single-bandwidth parameter obtained using cross-validation by testing them on various data sets. On an average, the proposed sparse kernel-based ensemble learning algorithm with optimized full-diagonal bandwidth parameters shows an improvement of 20% over the existing ensemble learning techniques. C1 [Gurram, Prudhvi; Kwon, Heesung] USA, Res Lab, Adelphi, MD 20783 USA. RP Gurram, P (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM pkgurram@gmail.com; heesung.kwon@us.army.mil NR 33 TC 16 Z9 16 U1 1 U2 25 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD FEB PY 2013 VL 51 IS 2 BP 787 EP 802 DI 10.1109/TGRS.2012.2203603 PG 16 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 077HW UT WOS:000314019500007 ER PT J AU Wright, L Crews, L Hundley, G AF Wright, L. Crews, L. Hundley, G. TI 4 YO WITH ATAXIA LAURA A. WRIGHT MD, LADONNA CREWS MD, GRACE HUNDLEY MD SO JOURNAL OF INVESTIGATIVE MEDICINE LA English DT Meeting Abstract CT Southern Regional Meeting of the American-Federation-for-Medical-Research CY FEB 21-23, 2013 CL New Orleans, LA SP Amer Federat Med Res, So Reg C1 [Wright, L.; Crews, L.] USA, Mobile, AL USA. [Hundley, G.] Univ S Alabama, Mobile, AL 36688 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1081-5589 J9 J INVEST MED JI J. Invest. Med. PD FEB PY 2013 VL 61 IS 2 MA 25 BP 379 EP 380 PG 2 WC Medicine, General & Internal; Medicine, Research & Experimental SC General & Internal Medicine; Research & Experimental Medicine GA 079FO UT WOS:000314156100039 ER PT J AU Wright, L Richerson, J AF Wright, L. Richerson, J. TI RARE BRAIN TUMOR DISGUISED AS ATAXIA IN A 23 MONTH OLD MALE SO JOURNAL OF INVESTIGATIVE MEDICINE LA English DT Meeting Abstract CT Southern Regional Meeting of the American-Federation-for-Medical-Research CY FEB 21-23, 2013 CL New Orleans, LA SP Amer Federat Med Res, So Reg C1 [Wright, L.; Richerson, J.] USA, Mobile, AL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1081-5589 J9 J INVEST MED JI J. Invest. Med. PD FEB PY 2013 VL 61 IS 2 MA 192 BP 426 EP 427 PG 2 WC Medicine, General & Internal; Medicine, Research & Experimental SC General & Internal Medicine; Research & Experimental Medicine GA 079FO UT WOS:000314156100207 ER PT J AU D'Souza, AJM Mar, KD Huang, J Majumdar, S Ford, BM Dyas, B Ulrich, RG Sullivan, VJ AF D'Souza, Ajit Joseph M. Mar, Kevin D. Huang, Joanne Majumdar, Sumit Ford, Brandi M. Dyas, Beverly Ulrich, Robert G. Sullivan, Vincent J. TI Rapid deamidation of recombinant protective antigen when adsorbed on aluminum hydroxide gel correlates with reduced potency of vaccine SO JOURNAL OF PHARMACEUTICAL SCIENCES LA English DT Article DE vaccines; deamidation; biotechnology; chemical stability; protein; formulation ID IN-VITRO CORRELATE; INHALATIONAL ANTHRAX; ASPARAGINE DEAMIDATION; MONOCLONAL-ANTIBODIES; RECEPTOR-BINDING; IMMUNITY; STABILITY; ADJUVANT; DOMAINS; RABBITS AB Deamidation of the recombinant protective antigen (rPA) correlates with decreased effectiveness of the vaccine in protecting against infection by Bacillus anthracis. We present data demonstrating dramatic deamidation of amino acid positions 713 and 719 of rPA adsorbed onto aluminum hydroxide gel, an adjuvant, relative to rPA stored in solution without adjuvant. Although deamidation did not impact total levels of rPA-specific antibodies in a mouse model, it did correlate with a decrease in toxin-neutralizing antibodies. On the basis of these data, we hypothesize that interactions of rPA with aluminum hydroxide gel are destabilizing and are the direct cause of reduced vaccine efficacy. (C) 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 102:454461, 2013 C1 [D'Souza, Ajit Joseph M.; Mar, Kevin D.; Huang, Joanne; Majumdar, Sumit; Ford, Brandi M.; Sullivan, Vincent J.] BD Technol, Res Triangle Pk, NC 27709 USA. [Dyas, Beverly; Ulrich, Robert G.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP D'Souza, AJM (reprint author), BD Technol, Res Triangle Pk, NC 27709 USA. EM ajit_dsouza@bd.com FU US Department of Defense [DAMD 17-03-2-0037] FX This work was funded in part by a grant from the US Department of Defense (award number DAMD 17-03-2-0037). NR 29 TC 10 Z9 10 U1 0 U2 19 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-3549 J9 J PHARM SCI-US JI J. Pharm. Sci. PD FEB PY 2013 VL 102 IS 2 BP 454 EP 461 DI 10.1002/jps.23422 PG 8 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology & Pharmacy SC Pharmacology & Pharmacy; Chemistry GA 074CO UT WOS:000313790100018 PM 23242822 ER PT J AU Shkuratov, Y Kaydash, V Korokhin, V Velikodsky, Y Petrov, D Zubko, E Stankevich, D Videen, G AF Shkuratov, Y. Kaydash, V. Korokhin, V. Velikodsky, Y. Petrov, D. Zubko, E. Stankevich, D. Videen, G. TI Response to the comment by B. Hapke on "A critical assessment of the Hapke photometric model" SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article DE Reflectance; Regolith; Photometry ID BIDIRECTIONAL REFLECTANCE SPECTROSCOPY; ASYMMETRY PARAMETERS; PHASE FUNCTION; SCATTERING; PARTICLES; SURFACES; LIGHT AB In this note we address critical comments given by Hapke (in this issue) [1] on our paper "A critical assessment of the Hapke photometric model" (Shkuratov et al., 2012 121) elaborating further on weak points of this model. One of the main problems of the H-model is the too free juggling with formulas, leading, in particular, to violation of energy conservation. The model is filled with ungrounded approximations and unsupported conclusions. Some of the model assumptions are mutually contradictory, e.g., it considers anisotropic single-particle phase functions to describe incoherent multiple scattering and simultaneously uses the isotropic function in order to calculate coherent backscattering. Another well-known problem of the H-model is that some of the model parameters have similar effects on the reflectance, which makes it difficult to retrieve unique parameter values. The model uses empirical parameters and, hence, is empirical. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Shkuratov, Y.; Kaydash, V.; Korokhin, V.; Velikodsky, Y.; Petrov, D.; Zubko, E.; Stankevich, D.] Kharkov VN Karazin Natl Univ, Astron Inst, UA-61022 Kharkov, Ukraine. [Shkuratov, Y.] Inst Radio Astron NASU, UA-61022 Kharkov, Ukraine. [Zubko, E.] Univ Helsinki, Dept Phys, FI-00014 Helsinki, Finland. [Videen, G.] Space Sci Inst, Boulder, CO 80301 USA. [Videen, G.] USA, Res Lab, Adelphi, MD 20783 USA. RP Shkuratov, Y (reprint author), Kharkov VN Karazin Natl Univ, Astron Inst, Sumskaya 35, UA-61022 Kharkov, Ukraine. EM yuriy.shkuratov@gmail.com OI Korokhin, Viktor/0000-0002-1911-3422; Velikodsky, Yuri/0000-0002-8219-128X NR 23 TC 6 Z9 6 U1 0 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD FEB PY 2013 VL 116 BP 191 EP 195 DI 10.1016/j.jqsrt.2012.11.004 PG 5 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 082YR UT WOS:000314430400019 ER PT J AU Duncan, DD Vogler, AJ Wolcott, MJ Li, F Sarovich, DS Birdsell, DN Watson, LM Hall, TA Sampath, R Housley, R Blyn, LB Hofstadler, SA Ecker, DJ Keim, P Wagner, DM Eshoo, MW AF Duncan, D. D. Vogler, A. J. Wolcott, M. J. Li, F. Sarovich, D. S. Birdsell, D. N. Watson, L. M. Hall, T. A. Sampath, R. Housley, R. Blyn, L. B. Hofstadler, S. A. Ecker, D. J. Keim, P. Wagner, D. M. Eshoo, M. W. TI Identification and typing of Francisella tularensis with a highly automated genotyping assay SO LETTERS IN APPLIED MICROBIOLOGY LA English DT Article DE biosurveillance; Francisella; microbial forensics; tularaemia ID TANDEM REPEAT ANALYSIS; REAL-TIME PCR; UNIVERSAL BIOSENSOR; MASS-SPECTROMETRY; MULTIPLE-LOCUS; TICKS; ENDOSYMBIONTS; POLYMERASE; TULAREMIA; SEQUENCE AB A PCR assay was developed to genotypically characterize Francisella tularensis and F. novicida. An integrated and partially redundant set of markers was selected to provide positive identification of these species, identify subspecies of F. tularensis and genotype 14 variable number tandem repeat (VNTR) markers. Assay performance was evaluated with 117 Francisella samples. Sample DNA was amplified, and the masses of the PCR products were determined with electrospray ionization/time of flight mass spectrometry (ESI-MS). The base compositions of the PCR amplicons were derived from these high-accuracy mass measurements and contrasted with databased information associated with each of the 25 assay markers. Species and subspecies determinations for all samples were fully concordant with results from established typing methods, and VNTR markers provided additional discrimination among samples. Sequence variants were observed with a number of assay markers, but these did not interfere with sample characterization, and served to increase the genetic diversity detected by the assay. Significance and Impact of the Study Molecular characterization of pathogenic subspecies of Francisella tularensis can be obscured by their near neighbours, which can be prevalent in environmental samples. This study describes a multilocus PCR assay for characterizing key species and subspecies of Francisella at multiple levels of resolution, using stable markers defining phylogenetic groups, together with more variable strain-defining markers. Target loci were selected to form an integrated and semi-redundant panel enabling robust identification of samples, including unique samples showing novel assay signatures. Analyses of environmental isolates and a diverse panel of curated samples exemplified the applications of this approach in surveillance and outbreak studies. C1 [Duncan, D. D.; Li, F.; Hall, T. A.; Sampath, R.; Housley, R.; Blyn, L. B.; Hofstadler, S. A.; Ecker, D. J.; Eshoo, M. W.] Ibis Biosci, Carlsbad, CA 92008 USA. [Vogler, A. J.; Sarovich, D. S.; Birdsell, D. N.; Watson, L. M.; Keim, P.; Wagner, D. M.] No Arizona Univ, Ctr Microbial Genet & Genom, Flagstaff, AZ 86011 USA. [Wolcott, M. J.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Duncan, DD (reprint author), Ibis Biosci, 2251 Faraday Ave,Suite 150, Carlsbad, CA 92008 USA. EM david.duncan@abbott.com OI Sarovich, Derek/0000-0002-6944-3980 FU Department of Homeland Security [NBCHC070041]; Joint Programme Executive Office - Chemical and Biological Defense - Critical Reagents Programme (JPEO-CBD-CRP) FX The technical assistance of D. Bedwell, W. Dorman, A. Shea, J. Carpenter, and H. Miner is gratefully acknowledged. This work was funded by the Department of Homeland Security contract NBCHC070041 and sponsored in part by the Joint Programme Executive Office - Chemical and Biological Defense - Critical Reagents Programme (JPEO-CBD-CRP). The interpretations and conclusions expressed in this paper are the private views of the authors and are not necessarily endorsed by the U.S. Army, the Department of Defense, or the Department of Homeland Security. NR 34 TC 6 Z9 6 U1 0 U2 15 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0266-8254 J9 LETT APPL MICROBIOL JI Lett. Appl. Microbiol. PD FEB PY 2013 VL 56 IS 2 BP 128 EP 134 DI 10.1111/lam.12022 PG 7 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 072XR UT WOS:000313707600008 PM 23121644 ER PT J AU Henning, PC Scofield, DE Rarick, KR Pierce, JR Staab, JS Lieberman, HR Nindl, BC AF Henning, Paul C. Scofield, Dennis E. Rarick, Kevin R. Pierce, Joseph R. Staab, Jeffery S. Lieberman, Harris R. Nindl, Bradley C. TI Effects of acute caloric restriction compared to caloric balance on the temporal response of the IGF-I system SO METABOLISM-CLINICAL AND EXPERIMENTAL LA English DT Article DE Insulin-like growth factor; Physiological status; Sustained Operations; Isocaloric ID GROWTH-FACTOR-I; FACTOR-BINDING PROTEIN-1; ACID-LABILE SUBUNIT; PHYSICAL-ACTIVITY; BODY-COMPOSITION; ENERGY DEFICIT; INSULIN; MEN; CONSEQUENCES; PROTEOLYSIS AB Objective. Insulin-like growth factor-I (IGF-I) is a key regulator of metabolism during altered energy states. The IGF-I system components respond to prolonged caloric restriction but it is not clear if this system responds similarly to acute caloric restriction. The purpose of this study was to characterize the IGF-I system response to acute caloric restriction with a secondary purpose of determining if two isocaloric diets with different ratios of carbohydrate to fat alter the IGF-I system under conditions of caloric balance. Materials/Methods. A double-blind, placebo-controlled crossover design was used in which 27 subjects underwent three, 48-h experimental treatments: 1) caloric restriction 2) carbohydrate and 3) carbohydrate/fat. Blood was sampled periodically (6 time points total) for IGF-I (total and free), IGFBP51-4, insulin and glucose. ANOVAs were used with significance set at P<0.05. Results. Total IGF-I decreased 7% during CR (P=0.051) and remained stable during CHO and CHO/F. Free IGF-I decreased 43% during CR (P<0.05) and remained stable during CHO and CHO/F. IGFBP-1 increased by 445% during CR (P<0.05) compared to CHO and CHO/F with no changes for IGFBP-2, IGFBP-3 and IGFBP-4. There was no change in glucose or insulin during CR over the course of the study. Insulin and glucose increased (P<0.05) after a meal in both the CHO and CHO/F groups with no difference between these two groups. Conclusion. Our findings indicate that free IGF-I decreases and IGFBP-1 increases during caloric restriction, but they are not altered with diets differing in carbohydrate and fat content. Changes in free IGF-I and IGFBP-1 are sensitive to caloric restriction, and their measurement may be valuable in monitoring the physiological response to refeeding in those consuming suboptimal calories. Published by Elsevier Inc. C1 [Henning, Paul C.; Scofield, Dennis E.; Rarick, Kevin R.; Pierce, Joseph R.; Staab, Jeffery S.; Nindl, Bradley C.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Lieberman, Harris R.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. RP Henning, PC (reprint author), USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. EM paul.c.henning@us.army.mil RI SCOFIELD, DENNIS/F-3636-2015 FU U.S. Army Medical Research and Material Command FX The authors would like to acknowledge Paul Maguire and Holly McClung for the development and preparation of the hydrocolloid-based gels, the technical assistance of Irene Potter, as well as the efforts of the staff and volunteers that made the data collection possible. This work was supported by the U.S. Army Medical Research and Material Command. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Army or the Department of Defense. Any citations of commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement of approval of the products or services of these organizations. NR 37 TC 5 Z9 5 U1 0 U2 11 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0026-0495 EI 1532-8600 J9 METABOLISM JI Metab.-Clin. Exp. PD FEB PY 2013 VL 62 IS 2 BP 179 EP 187 DI 10.1016/j.metabol.2012.07.004 PG 9 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 083AY UT WOS:000314436300002 PM 22906764 ER PT J AU Pusateri, AE Weiskopf, RB Bebarta, V Butler, F Cestero, RF Chaudry, IH Deal, V Dorlac, WC Gerhardt, RT Given, MB Hansen, DR Hoots, WK Klein, HG Macdonald, VW Mattox, KL Michael, RA Mogford, J Montcalm-Smith, EA Niemeyer, DM Prusaczyk, WK Rappold, JF Rassmussen, T Rentas, F Ross, J Thompson, C Tucker, LD AF Pusateri, Anthony E. Weiskopf, Richard B. Bebarta, Vikhyat Butler, Frank Cestero, Ramon F. Chaudry, Irshad H. Deal, Virgil Dorlac, Warren C. Gerhardt, Robert T. Given, Michael B. Hansen, Dan R. Hoots, W. Keith Klein, Harvey G. Macdonald, Victor W. Mattox, Kenneth L. Michael, Rodney A. Mogford, Jon Montcalm-Smith, Elizabeth A. Niemeyer, Debra M. Prusaczyk, W. Keith Rappold, Joseph F. Rassmussen, Todd Rentas, Francisco Ross, James Thompson, Christopher Tucker, Leo D. CA US DoD Hemorrhage Resuscitation Re TI TRANEXAMIC ACID AND TRAUMA: CURRENT STATUS AND KNOWLEDGE GAPS WITH RECOMMENDED RESEARCH PRIORITIES SO SHOCK LA English DT Review DE Tranexamic acid; trauma; efficacy; safety; research requirements ID PLACEBO-CONTROLLED TRIAL; CARDIAC-SURGERY; CARDIOPULMONARY BYPASS; SEIZURES; APROTININ; HEMORRHAGE; TRANSFUSION; CRASH-2; SAFETY AB A recent large civilian randomized controlled trial on the use of tranexamic acid (TXA) for trauma reported important survival benefits. Subsequently, successful use of TXA for combat casualties in Afghanistan was also reported. As a result of these promising studies, there has been growing interest in the use of TXA for trauma. Potential adverse effects of TXA have also been reported. A US Department of Defense committee conducted a review and assessment of knowledge gaps and research requirements regarding the use of TXA for the treatment of casualties that have experienced traumatic hemorrhage. We present identified knowledge gaps and associated research priorities. We believe that important knowledge gaps exist and that a targeted, prioritized research effort will contribute to the refinement of practice guidelines over time. C1 [Pusateri, Anthony E.] USA, Med Res & Mat Command, Ft Detrick, MD 21702 USA. [Weiskopf, Richard B.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Butler, Frank] Def Hlth Board, Comm Tact Combat Casualty Care, Pensacola, FL USA. [Cestero, Ramon F.; Ross, James] USN, Med Res Unit, Ft Sam Houston, TX USA. [Chaudry, Irshad H.] Univ Alabama Birmingham, Birmingham, AL USA. [Deal, Virgil] US Special Operat Command, Macdill AFB, FL USA. [Dorlac, Warren C.] Univ Cincinnati, Ctr Sustainment Trauma & Readiness Skills, Cincinnati, OH USA. [Gerhardt, Robert T.; Rassmussen, Todd] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Given, Michael B.] Off Naval Res, Arlington, VA 22217 USA. [Hoots, W. Keith] NHLBI, Bethesda, MD 20892 USA. [Klein, Harvey G.] NIH, Ctr Clin, Bethesda, MD 20892 USA. [Macdonald, Victor W.; Michael, Rodney A.] US Army Med Mat Dev Act, Ft Detrick, MD USA. [Mattox, Kenneth L.] Baylor Coll Med, Houston, TX 77030 USA. [Mogford, Jon] Def Adv Res Projects Agcy, Arlington, VA USA. [Montcalm-Smith, Elizabeth A.] USN, Med Res Ctr, Silver Spring, MD USA. [Prusaczyk, W. Keith] USN, Med Res & Dev Ctr, Frederick, MD USA. [Rappold, Joseph F.] USN, Med Ctr, San Diego, CA 92152 USA. [Rentas, Francisco] US Armed Serv Blood Program Off, Falls Church, VA USA. [Thompson, Christopher] USN, Undersea Med Inst, Groton, CT USA. [Tucker, Leo D.] USA, Med Ctr & Sch, Ft Sam Houston, TX USA. RP Pusateri, AE (reprint author), USA, DoD Hemorrhage & Resuscitat Res & Dev Program, Combat Casualty Care Res Program, Med Res & Mat Command, Bldg 722, Ft Detrick, MD 21702 USA. EM anthony.pusateri@amedd.army.mil RI bebarta, vikhyat/K-3476-2015 NR 34 TC 39 Z9 39 U1 0 U2 11 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD FEB PY 2013 VL 39 IS 2 BP 121 EP 126 DI 10.1097/SHK.0b013e318280409a PG 6 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 080ZF UT WOS:000314282900002 PM 23222525 ER PT J AU Jaligama, S Kale, VM Wilbanks, MS Perkins, EJ Meyer, SA AF Jaligama, Sridhar Kale, Vijay M. Wilbanks, Mitchell S. Perkins, Edward J. Meyer, Sharon A. TI Delayed myelosuppression with acute exposure to hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and environmental degradation product hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX) in rats SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article DE Munitions; Hematotoxicity; Hematopoiesis; Bone marrow ID HEMATOPOIETIC STEM-CELLS; BONE-MARROW; CYCLOTRIMETHYLENETRINITRAMINE RDX; HEMOLYTIC-ANEMIA; SEIZURE ACTIVITY; COMPOSITION C-4; FLOW-CYTOMETRY; CFU-GM; BENZENE; MICE AB Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), a widely used munitions compound, and hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX), its N-nitroso product of anaerobic microbial nitroreduction, are contaminants of military sites. Previous studies have shown MNX to be the most acutely toxic among the nitroreduced degradation products of RDX and to cause mild anemia at high dose. The present study compares hematotoxicity with acute oral exposure to MNX with parent RDX. Both RDX and MNX caused a modest decrease in blood hemoglobin and similar to 50% loss of granulocytes (NOAELs = 47 mg/kg) in female Sprague-Dawley rats observed 14 days post-exposure. We explored the possibility that blood cell loss observed after 14 days was delayed in onset because of toxicity to bone marrow (BM) progenitors. RDX and MNX decreased granulocyte/macrophage-colony forming cells (GM-CFCs) at 14, but not 7, days (NOAELs = 24 mg/kg). The earliest observed time at which MNX decreased GM-CFCs was 10 days post-exposure. RDX and MNX likewise decreased BM burst-forming units-erythroid (BFU-Es) at 14, but not 7, days. Granulocyte-erythrocyte-monocyte-megakaryocyte (GEMM)-CFCs were unaffected by RDX and MNX at 7 days suggesting precursor depletion did not account for GM-CFC and BFU-E loss. MNX added to the culture media was without effect on GM-CFC formation indicating no direct inhibition. Flow cytometry showed no differential loss of BM multilineage progenitors (Thy1.1(+)) or erythroid (CD71(+)) precursors with MNX suggesting myeloid and erythroid lineages were comparably affected. Collectively, these data indicate that acute exposure to both RDX and MNX caused delayed suppression of myelo- and erythropoiesis with subsequent decrease of peripheral granulocytes and erythrocytes. (C) 2012 Elsevier Inc. All rights reserved. C1 [Jaligama, Sridhar; Kale, Vijay M.; Wilbanks, Mitchell S.; Meyer, Sharon A.] Univ Louisiana Monroe, Dept Toxicol, Coll Pharm, Monroe, LA 71201 USA. [Perkins, Edward J.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Meyer, SA (reprint author), Univ Louisiana Monroe, Dept Toxicol, Coll Pharm, 1800 Bienville Dr, Monroe, LA 71201 USA. EM meyer@ulm.edu RI Jaligama, Sridhar/D-5533-2015 OI Jaligama, Sridhar/0000-0001-6374-3336 FU US Depatment of Defense [W81XWH-05-10537, W912HZ-05-P-0145] FX This study was supported by US Depatment of Defense, grant no. W81XWH-05-10537 and contract no. W912HZ-05-P-0145. NR 61 TC 0 Z9 0 U1 0 U2 10 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0041-008X EI 1096-0333 J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD FEB 1 PY 2013 VL 266 IS 3 BP 443 EP 451 DI 10.1016/j.taap.2012.11.022 PG 9 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 081NN UT WOS:000314329000013 PM 23219714 ER PT J AU Payne, OJ Graham, SJ Dalton, CH Spencer, PM Mansson, R Jenner, J Azeke, J Braue, E AF Payne, O. J. Graham, S. J. Dalton, C. H. Spencer, P. M. Mansson, R. Jenner, J. Azeke, J. Braue, E. TI The effects of sulfur mustard exposure and freezing on transdermal penetration of tritiated water through ex vivo pig skin SO TOXICOLOGY IN VITRO LA English DT Article DE Sulfur mustard; Freezing; Pig skin; Permeation ID VITRO PERCUTANEOUS-ABSORPTION; IN-VITRO; STORAGE-CONDITIONS; PERMEABILITY; DELIVERY; MODELS; BURNS AB The percutaneous absorption of tritiated water ((H2O)-H-3) through sulfur mustard (SM) exposed abdominal pig skin was measured using in vitro Franz-type static diffusion cells. The barrier function to water permeation following exposure to liquid SM for 8 min and excision 3 h later did not change significantly. A small, but statistically significant difference (P < 0.05) in steady state penetration (Jss), permeability coefficient (Kp) and lag time (t(L)) of (H2O)-H-3 was observed between fresh skin and skin stored frozen (-20 degrees C) for up to two weeks. Steady-state penetration and Kp values were significantly higher (P < 0.05) in skin stored frozen compared with fresh skin. Fresh naive skin had an average Kp of 1.65 x 10(-3) cm h(-1), whereas frozen naive skin was 2.04 x 10(-3) cm h(-1). Fresh SM exposed skin had a mean Kp of 1.72 x 10(-3) - cm h(-1), whereas frozen SM exposed skin was 2.31 x 10(-3) cm h(-1). Lag times were also shorter (P < 0.05) in skin that had been stored frozen. Frozen, SM-exposed porcine abdominal skin may be used for in vitro penetration studies, but effects of treatment and storage on the barrier layer should be taken into account. (c) 2012 Elsevier Ltd. All rights reserved. C1 [Payne, O. J.; Graham, S. J.; Dalton, C. H.; Jenner, J.] Def Sci & Technol Lab, Dept Biomed Sci, Salisbury SP4 0JQ, Wilts, England. [Spencer, P. M.; Mansson, R.] Def Sci & Technol Lab, Dept Detect, Salisbury SP4 0JQ, Wilts, England. [Azeke, J.; Braue, E.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Payne, OJ (reprint author), Def Sci & Technol Lab, Dept Biomed Sci, Salisbury SP4 0JQ, Wilts, England. EM opayne@dstl.gov.uk RI Dalton, Christopher/J-5747-2016 OI Dalton, Christopher/0000-0001-7021-781X FU US Army Medical Research and Materiel Command [W81XWH-08-C-0070] FX This work is supported by the US Army Medical Research and Materiel Command under contract No. W81XWH-08-C-0070. The authors would like to thank the technical assistance kindly provided by Rosi Perrott and Stephen Rutter. NR 30 TC 3 Z9 3 U1 1 U2 15 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0887-2333 J9 TOXICOL IN VITRO JI Toxicol. Vitro PD FEB PY 2013 VL 27 IS 1 BP 79 EP 83 DI 10.1016/j.tiv.2012.09.015 PG 5 WC Toxicology SC Toxicology GA 082DD UT WOS:000314371600010 PM 23041075 ER PT J AU Chandrasekaran, L Belinskaya, T Saxena, A AF Chandrasekaran, Lakshmi Belinskaya, Tatyana Saxena, Ashima TI In vitro characterization of organophosphorus compound hydrolysis by native and recombinant human prolidase SO TOXICOLOGY IN VITRO LA English DT Article DE Recombinant; Erythrocytes; Human prolidase; Bioscavenger; OP hydrolysis ID HUMAN-ERYTHROCYTE PROLIDASE; PYROCOCCUS-FURIOSUS; KIDNEY PROLIDASE; PURIFICATION; DEFICIENCY; PROTEINS; ENZYME; ACETYLCHOLINESTERASE; EXPRESSION; PATIENT AB Human prolidase is a binuclear metalloenzyme, which can potentially function as a catalytic bioscavenger for organophosphorus (OP) nerve agents. Although the biochemical properties of native prolidase purified from human erythrocytes, liver, kidney, and fibroblast cells are well known, it is very poorly characterized with regard to its OP hydrolyzing activity. Also, the high cost of purification of large quantities of native enzyme limits its use as a bioscavenger. Thus, recombinant human prolidase with similar biochemical properties to those of native enzyme would be more suitable as a catalytic bioscavenger. In this study, we established an Escherichia coli expression system, which produced a large amount of tagged human liver prolidase that was purified to over 95% purity from the soluble fraction of cell lysate by affinity chromatography on Streptavidin-agarose resin. The catalytic properties of the recombinant enzyme were compared in vitro with those of highly purified prolidase I isolated from human erythrocytes. The catalytic properties of recombinant prolidase overlap with those of the erythrocyte-derived native enzyme. Both enzymes efficiently hydrolyzed diisopropylfluorophosphate, sarin, soman, tabun and cyclosarin, but were much less efficient at hydrolyzing paraoxon and methyl paraoxon. These results suggest that human prolidase expressed in E. coli is suitable for further development as a catalytic bioscavenger for OP nerve agents. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Chandrasekaran, Lakshmi; Belinskaya, Tatyana; Saxena, Ashima] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. RP Saxena, A (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM ashima.saxena@us.army.mil FU Defense Threat Reduction Agency FX The authors wish to thank Dr. Robert diTargiani for conducting OP hydrolysis studies with erythrocyte prolidase, Dr. Neil Jensen and staff at the Collaborative Research Facility at USAMRICD for help in conducting studies with OP nerve agents, and Ms. Amy Michels for assistance in preparation of the manuscript. This research was supported by funding from the Defense Threat Reduction Agency. NR 34 TC 3 Z9 3 U1 1 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0887-2333 J9 TOXICOL IN VITRO JI Toxicol. Vitro PD FEB PY 2013 VL 27 IS 1 BP 499 EP 506 DI 10.1016/j.tiv.2012.05.012 PG 8 WC Toxicology SC Toxicology GA 082DD UT WOS:000314371600060 PM 22677456 ER PT J AU Javitt, MC AF Javitt, Marcia C. TI Section Editor's Notebook: Technical Advances in Women's Imaging and the "Digital Native" SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Editorial Material C1 Uniformed Serv Univ Hlth Sci, Walter Reed Army Med Ctr, Bethesda, MD 20814 USA. RP Javitt, MC (reprint author), Uniformed Serv Univ Hlth Sci, Walter Reed Army Med Ctr, Bethesda, MD 20814 USA. EM femscan@aol.com NR 6 TC 0 Z9 0 U1 0 U2 3 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD FEB PY 2013 VL 200 IS 2 BP 248 EP 248 DI 10.2214/AJR.12.9261 PG 1 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 076LG UT WOS:000313957400021 PM 23345343 ER PT J AU Cohen, SP Galvagno, SM Plunkett, A Harris, D Kurihara, C Turabi, A Rehrig, S Buckenmaier, CC Chelly, JE AF Cohen, Steven P. Galvagno, Samuel M. Plunkett, Anthony Harris, Diamond Kurihara, Connie Turabi, Ali Rehrig, Scott Buckenmaier, Chester C., III Chelly, Jacques E. TI A Multicenter, Randomized, Controlled Study Evaluating Preventive Etanercept on Postoperative Pain After Inguinal Hernia Repair SO ANESTHESIA AND ANALGESIA LA English DT Article ID TUMOR-NECROSIS-FACTOR; CHRONIC CONSTRICTION INJURY; FACTOR-ALPHA; RISK-FACTORS; GROIN HERNIA; THORACIC-SURGERY; NEUROPATHIC PAIN; LIMB AMPUTATION; PHANTOM LIMB; NERVE AB BACKGROUND: Chronic postsurgical pain (CPSP) affects between 5% and 70% of surgical patients, depending on the surgery. There is no reliable treatment for CPSP which has led to an increased emphasis on prevention. In this study, we sought to determine whether preventive etanercept can decrease the magnitude of postoperative pain and reduce the incidence of CPSP METHODS: We performed a multicenter, randomized study in 7:7 patients comparing subcutaneous etanercept 50 mg administered 90 minutes before inguinal hernia surgery with saline. Patients, surgeons, anesthesiologists, the injecting physician, nursing staff, and evaluators were blinded. The primary outcome measure was a 24-hour numerical rating scale pain score. Secondary outcome measures were postanesthesia care unit pain scores, 24-hour opioid requirements, time to first analgesic, and pain scores recorded at 1 month, 3 months, 6 months, and 12 months. RESULTS: Mean 24-hour pain scores were 3.3 (95% confidence interval [CI], 3.2-4.6) in the etanercept and 3.9 (95% Cl, 2.6-4.0) in the control group (P = 0.22). The mean number of analgesic pills used in the first 24 hours was 4.0 (SD, 2.8) in the treatment versus 5.8 (SD, 4.2) in the control group (P = 0.03). At 1 month, 10 patients (29%) in the treatment group reported pain versus 21 (49%) control patients (P = 0,08). The presence of pain at 1 month was significantly associated with pain at 3 months (hazard ratio, 0.74; 99% CI, 0.52-0.97; P = 0.03). CONCLUSION: Although preventive etanercept was superior to saline in reducing postoperative pain on some measures, the effect sizes were small, transient, and not statistically significant. Different dosing regimens in a larger population should be explored in future studies. (Anesth Analg 2013;116:455-62) C1 [Cohen, Steven P.; Kurihara, Connie; Turabi, Ali; Buckenmaier, Chester C., III] Walter Reed Natl Mil Med Ctr, Dept Anesthesiol, Baltimore, MD 21205 USA. [Rehrig, Scott] Walter Reed Natl Mil Med Ctr, Dept Surg, Baltimore, MD 21205 USA. [Cohen, Steven P.] Johns Hopkins Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD USA. [Galvagno, Samuel M.] Univ Maryland, Med Ctr, Dept Anesthesiol, Baltimore, MD 21201 USA. Joint Base Andrews, Andrews AFB, MD USA. [Plunkett, Anthony] Womack Army Med Ctr, Dept Anesthesiol, Ft Bragg, NC USA. [Harris, Diamond; Chelly, Jacques E.] Univ Pittsburgh, Sch Med, Dept Anesthesiol, Pittsburgh, PA 15261 USA. [Buckenmaier, Chester C., III] Def & Vet Ctr Integrat Pain Management, Rockville, MD USA. RP Cohen, SP (reprint author), Walter Reed Natl Mil Med Ctr, Dept Anesthesiol, 550 N Broadway,Suite 301, Baltimore, MD 21205 USA. EM scohen40@jhmi.edu OI rehrig, scott/0000-0002-1287-9708 FU Defense and Veterans Center for Integrative Pain Management, Rockville, MD FX Supported in part by a Congressional Grant from the Defense and Veterans Center for Integrative Pain Management, Rockville, MD. NR 42 TC 13 Z9 14 U1 1 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD FEB PY 2013 VL 116 IS 2 BP 455 EP 462 DI 10.1213/ANE.0b013e318273f71c PG 8 WC Anesthesiology SC Anesthesiology GA 078DJ UT WOS:000314078300030 PM 23302973 ER PT J AU Beltran, MJ Blair, JA Huh, J Kirby, JM Hsu, JR AF Beltran, Michael J. Blair, James A. Huh, Jeannie Kirby, Jess M. Hsu, Joseph R. CA Skeletal Trauma Res Consortium TI Articular exposure with the swashbuckler versus a "Mini-swashbuckler" approach SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED LA English DT Article DE Swashbuckler; Distal femur; Minimally invasive; Articular ID DISTAL FEMORAL FRACTURES; INVASIVE STABILIZATION SYSTEM; INDIRECT REDUCTION; FEMUR FRACTURES; UNSTABLE FRACTURES; INTERNAL-FIXATION; EXPERIENCE; PART AB Objective: To quantify the articular exposure obtained with a Swashbuckler approach to the distal femur and compare this to a "Mini-swashbuckler" approach. Methods: Forty surgical approaches in 20 fresh-frozen hemipelvis specimens were performed using a Mini-swashbuckler approach followed by a traditional Swashbuckler. Key anatomic landmarks, including the posterior femoral condyles, intercondylar notch, and medial articular margin, were either directly visualised or palpated with a tonsil clamp. Calibrated digital photographs were taken from the surgeon's viewing perspective after each approach. The digital images were then analyzed using a computer software programme, ImageJ (NIH, Bethesda, MD), to calculate the articular surface square area exposed. Results: The Mini-swashbuckler exposed 87% of the articular surface compared to the Swashbuckler approach (29.48 cm(2) vs 34.03 cm(2), p < 0.0001). Key anatomic landmarks were directly visualised with both exposures in all subjects, including limbs with severe osteoarthritis. Greater exposure with the Mini-swashbuckler correlated with male gender (p < 0.05) and height (p = 0.03) but not weight or BMI. Conclusions: Although exposure is improved with the use of a Swashbuckler, this difference may not be of clinical importance, since both approaches give either direct visual or tactile access to all critical areas of the distal femur, including the trochlea, entire medial compartment, and both posterior femoral condyles. A less invasive approach allows a smaller surgical dissection without sacrificing the ability to visualise the majority of the articular surface. Published by Elsevier Ltd. C1 [Beltran, Michael J.; Blair, James A.; Huh, Jeannie] San Antonio Mil Med Ctr, Dept Orthopaed & Rehabil, San Antonio, TX 78234 USA. [Kirby, Jess M.] USATTC Ryder Trauma Ctr, Dept Orthopaed, Miami, FL 33136 USA. [Hsu, Joseph R.] USA, Dept Orthopaed & Rehabil, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Beltran, MJ (reprint author), Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. EM Michael.beltran@amedd.army.mil; James.blair@amedd.army.mil; Jeannie.huh@amedd.army.mil; Joseph.Hsu@amedd.army.mil; Jess.Kirby@amedd.army.mil NR 24 TC 5 Z9 5 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0020-1383 J9 INJURY JI Injury-Int. J. Care Inj. PD FEB PY 2013 VL 44 IS 2 BP 189 EP 193 DI 10.1016/j.injury.2012.10.021 PG 5 WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery GA 072VL UT WOS:000313701300007 PM 23237603 ER PT J AU Eberly, JO Ringelberg, DB Indest, KJ AF Eberly, Jed O. Ringelberg, David B. Indest, Karl J. TI Physiological characterization of lipid accumulation and in vivo ester formation in Gordonia sp KTR9 SO JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY LA English DT Article DE Biodiesel; Triacylglcerides; Fatty acid esters; Gordonia ID RHODOCOCCUS-ERYTHROPOLIS; BIOFUEL PRODUCTION; ESCHERICHIA-COLI; TRIACYLGLYCEROL; MICROBES; ALCOHOLS; BACTERIA; BIOLOGY; GROWTH; ADP1 AB Previous work has demonstrated the feasibility of in vivo biodiesel synthesis in Escherichia coli, however, ethyl ester formation was dependent on an external fatty acid feedstock. In contrast to E. coli, actinomycetes may be ideal organisms for direct biodiesel synthesis because of their capacity to synthesize high levels of triacylglcerides (TAGs). In this study, we investigated the physiology and associated TAG accumulation along with the in vivo ability to catalyze ester formation from exogenous short chain alcohol sources in Gordonia sp. KTR9, a strain that possesses a large number of genes dedicated to fatty acid and lipid biosynthesis. Total lipid fatty acids content increased by 75 % and TAG content increased by 50 % under nitrogen starvation conditions in strain KTR9. Strain KTR9 tolerated the exogenous addition of up to 4 % methanol, 4 % ethanol and 2 % propanol in the media. Increasing alcohol concentrations resulted in a decrease in the degree of saturation of recovered fatty acid alcohol esters and a slight increase in the fatty acid chain length. A linear dose dependency in fatty alcohol ester synthesis was observed in the presence of 0.5-2 % methanol and ethanol compared to control KTR9 strains grown in the absence of alcohols. An inspection of the KTR9 genome revealed the presence of several putative wax ester synthase/acyl-coenzyme AaEuroS:aEuroSdiacylglycerol acyltransferase (WS/DGAT) enzymes, encoded by atf gene homologs, that may catalyze the in vivo synthesis of fatty acid esters from short chain alcohols. Collectively, these results indicate that Gordonia sp. KTR9 may be a suitable actinomycete host strain for in vivo biodiesel synthesis. C1 [Eberly, Jed O.; Indest, Karl J.] USA, Environm Lab, CEERD EP P, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Ringelberg, David B.] USA, Cold Reg Res & Engn Lab, Engn Res & Dev Ctr, Hanover, NH 03755 USA. RP Indest, KJ (reprint author), USA, Environm Lab, CEERD EP P, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Karl.J.Indest@usace.army.mil FU U.S. Army Corps of Engineers Environmental Quality Program [10-50] FX This research was funded through the U.S. Army Corps of Engineers Environmental Quality Program (Project 10-50, K. J. Indest). Views, opinions and/or findings contained herein are those of the authors and should not be construed as an official Department of the Army position or decision unless so designated by other official documentation. We thank Dr. Larry Kirk for technical assistance. NR 28 TC 3 Z9 4 U1 3 U2 22 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1367-5435 J9 J IND MICROBIOL BIOT JI J. Ind. Microbiol. Biotechnol. PD FEB PY 2013 VL 40 IS 2 BP 201 EP 208 DI 10.1007/s10295-012-1218-6 PG 8 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 074RI UT WOS:000313830400004 PM 23207981 ER PT J AU Chen, SG Zhang, J Lumley, L Cashman, JR AF Chen, Sigeng Zhang, Jun Lumley, Lucille Cashman, John R. TI Immunodetection of Serum Albumin Adducts as Biomarkers for Organophosphorus Exposure SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS LA English DT Article ID INHIBITION ENZYME-IMMUNOASSAY; TRICHOTHECENE MYCOTOXIN T-2; AGENT FP-BIOTIN; MONOCLONAL-ANTIBODIES; MASS-SPECTROMETRY; SOMAN; ACETYLCHOLINESTERASE; HYDROLYSIS; BUTYRYLCHOLINESTERASE; CHOLINESTERASES AB A major challenge in organophosphate (OP) research has been the identification and utilization of reliable biomarkers for the rapid, sensitive, and efficient detection of OP exposure. Although Tyr 411 OP adducts to human serum albumin (HSA) have been suggested to be one of the most robust biomarkers in the detection of OP exposure, the analysis of HSA-OP adduct detection has been limited to techniques using mass spectrometry. Herein, we describe the procurement of two monoclonal antibodies (mAb-HSA-GD and mAb-HSA-VX) that recognized the HSA Tyr 411 adduct of soman (GD) or S-[2-(diisopropylamino)ethyl]-O-ethyl methylphosphonothioate (VX), respectively, but did not recognize nonphosphonylated HSA. We showed that mAb-HSA-GD was able to detect the HSA Tyr 411 OP adduct at a low level (i.e., human blood plasma treated with 180 nM GD) that could not be detected by mass spectrometry. mAb-HSA-GD and mAb-HSA-VX showed an extremely low-level detection of GD adducted to HSA (on the order of picograms). mAb-HSA-GD could also detect serum albumin OP adducts in blood plasma samples from different animals administered GD, including rats, guinea pigs, and monkeys. The ability of the two antibodies to selectively recognize nerve agents adducted to serum albumin suggests that these antibodies could be used to identify biomarkers of OP exposure and provide a new biologic approach to detect OP exposure in animals. C1 [Chen, Sigeng; Zhang, Jun; Cashman, John R.] Human BioMol Res Inst, San Diego, CA 92121 USA. [Lumley, Lucille] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Cashman, JR (reprint author), Human BioMol Res Inst, 5310 Eastgate Mall, San Diego, CA 92121 USA. EM jcashman@hbri.org RI Chen, Sigeng/G-1678-2014 FU CounterACT Program, National Institutes of Health Office of the Director; National Institutes of Health National Institute of Neurological Disorders and Stroke [UO1 NS058038] FX This work was supported by the CounterACT Program, National Institutes of Health Office of the Director, and National Institutes of Health National Institute of Neurological Disorders and Stroke [Grant UO1 NS058038] (J.R.C). Its contents are solely the responsibility of the authors and do not necessarily represent the official view of the federal government. NR 38 TC 7 Z9 9 U1 1 U2 26 PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA SN 0022-3565 J9 J PHARMACOL EXP THER JI J. Pharmacol. Exp. Ther. PD FEB PY 2013 VL 344 IS 2 BP 531 EP 541 DI 10.1124/jpet.112.201368 PG 11 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 073MA UT WOS:000313745900022 PM 23192655 ER PT J AU Burgess, E AF Burgess, Edwin TI The Year Without Summer: 1816 and the Volcano That Darkened the World and Changed History SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, E (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 3 U2 10 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD FEB 1 PY 2013 VL 138 IS 2 BP 74 EP 74 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 078GD UT WOS:000314085800136 ER PT J AU Busby, RR Stromberger, ME Rodriguez, G Gebhart, DL Paschke, MW AF Busby, Ryan R. Stromberger, Mary E. Rodriguez, Giselle Gebhart, Dick L. Paschke, Mark W. TI Arbuscular mycorrhizal fungal community differs between a coexisting native shrub and introduced annual grass SO MYCORRHIZA LA English DT Article DE Arbuscular mycorrhizal fungi; Artemisia tridentata; Bromus tectorum; Diversity; Ecological restoration; Plant invasion ID INVASIVE PLANT SUPPRESSES; BROMUS-TECTORUM-L; ENDOMYCORRHIZAL FUNGI; TALLGRASS PRAIRIE; EXOTIC GRASSES; SOIL BIOTA; ROOTS; ECOSYSTEMS; DIVERSITY; FIELD AB Arbuscular mycorrhizal fungi (AMF) have been implicated in non-native plant invasion success and persistence. However, few studies have identified the AMF species associating directly with plant invaders, or how these associations differ from those of native plant species. Identifying changes to the AMF community due to plant invasion could yield key plant-AMF interactions necessary for the restoration of native plant communities. This research compared AMF associating with coexisting Bromus tectorum, an invasive annual grass, and Artemisia tridentata, the dominant native shrub in western North America. At three sites, soil and root samples from Bromus and Artemisia were collected. Sporulation was induced using trap cultures, and spores were identified using morphological characteristics. DNA was extracted from root and soil subsamples and amplified. Sequences obtained were aligned and analyzed to compare diversity, composition, and phylogenetic distance between hosts and sites. Richness of AMF species associated with Artemisia in cultures was higher than AMF species associated with Bromus. Gamma diversity was similar and beta diversity was higher in AMF associated with Bromus compared to Artemisia. AMF community composition differed between hosts in both cultures and roots. Two AMF species (Archaeospora trappei and Viscospora viscosum) associated more frequently with Artemisia than Bromus across multiple sites. AMF communities in Bromus roots were more phylogenetically dispersed than in Artemisia roots, indicating a greater competition for resources within the invasive grass. Bromus associated with an AMF community that differed from Artemisia in a number of ways, and these changes could restrict native plant establishment. C1 [Busby, Ryan R.; Stromberger, Mary E.; Paschke, Mark W.] Colorado State Univ, Grad Degree Program Ecol, Ft Collins, CO 80523 USA. [Busby, Ryan R.; Rodriguez, Giselle; Gebhart, Dick L.] USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. [Stromberger, Mary E.] Colorado State Univ, Dept Soil & Crop Sci, Ft Collins, CO 80523 USA. [Paschke, Mark W.] Colorado State Univ, Dept Forest Rangeland & Watershed Stewardship, Ft Collins, CO 80523 USA. RP Busby, RR (reprint author), USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, 2902 Newmark Dr, Champaign, IL 61826 USA. EM Ryan.R.Busby@usace.army.mil RI Stromberger, Mary/C-3070-2013; Paschke, Mark/E-3799-2013 OI Stromberger, Mary/0000-0002-5862-2932; Paschke, Mark/0000-0002-6345-5905 FU United States Army A896 Direct Funded Research Program FX The authors thank H. Varani, B. Wolk, L. Bodistow, A. Broz, and the CSU Sequencing Lab (Colorado State University); J. Morton, R. Bills, S. Purin, and B. Wheeler (INVAM); J. Bever and W. Kaonongbua (Indiana University); and N. Raizen (University of Illinois). This research was funded by the United States Army A896 Direct Funded Research Program. NR 68 TC 12 Z9 13 U1 10 U2 135 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0940-6360 J9 MYCORRHIZA JI Mycorrhiza PD FEB PY 2013 VL 23 IS 2 BP 129 EP 141 DI 10.1007/s00572-012-0455-x PG 13 WC Mycology SC Mycology GA 077VO UT WOS:000314057300005 PM 22864708 ER PT J AU Lee, I Choi, KK Noh, Y Lamb, D AF Lee, Ikjin Choi, K. K. Noh, Yoojeong Lamb, David TI Comparison study between probabilistic and possibilistic methods for problems under a lack of correlated input statistical information SO STRUCTURAL AND MULTIDISCIPLINARY OPTIMIZATION LA English DT Article DE Identification of joint and marginal CDFs; Confidence level; Reliability-based design optimization (RBDO); Possibility-based design optimization (PBDO); Correlated input; Copula ID RELIABILITY-BASED DESIGN; DIMENSION REDUCTION; OPTIMIZATION AB In most industrial applications, only limited statistical information is available to describe the input uncertainty model due to expensive experimental testing costs. It would be unreliable to use the estimated input uncertainty model obtained from insufficient data for the design optimization. Furthermore, when input variables are correlated, we would obtain non-optimum design if we assume that they are independent. In this paper, two methods for problems with a lack of input statistical information-possibility-based design optimization (PBDO) and reliability-based design optimization (RBDO) with confidence level on the input model-are compared using mathematical examples and an Abrams M1A1 tank roadarm example. The comparison study shows that PBDO could provide an unreliable optimum design when the number of samples is very small. In addition, PBDO provides an optimum design that is too conservative when the number of samples is relatively large. Furthermore, the obtained PBDO designs do not converge to the optimum design obtained using the true input distribution as the number of samples increases. On the other hand, RBDO with confidence level on the input model provides a conservative and reliable optimum design in a stable manner. The obtained RBDO designs converge to the optimum design obtained using the true input distribution as the number of samples increases. C1 [Lee, Ikjin] Univ Connecticut, Dept Mech Engn, Storrs, CT 06269 USA. [Choi, K. K.] Univ Iowa, Dept Mech & Ind Engn, Iowa City, IA 52242 USA. [Choi, K. K.] Seoul Natl Univ, Dept Naval Architecture & Ocean Engn, Seoul, South Korea. [Noh, Yoojeong] Keimyung Univ, Dept Mech & Automot Engn, Taegu 704701, South Korea. [Lamb, David] USA, RDECOM TARDEC, Warren, MI 48397 USA. RP Choi, KK (reprint author), Univ Iowa, Dept Mech & Ind Engn, Iowa City, IA 52242 USA. EM ilee@engr.uconn.edu; kkchoi@engineering.uiowa.edu; romana79@kmu.ac.kr; david.lamb@us.army.mil RI Lee, IkJin/I-4722-2013; Choi, Kyung/B-1512-2008; Noh, Yoojeong/E-9833-2015 OI Choi, Kyung/0000-0003-2384-6220; FU Automotive Research Center; U.S. Army Tank Automotive Research, Development and Engineering Center (TARDEC); World Class University Program through the National Research Foundation of Korea (NRF); Ministry of Education, Science and Technology [R32-2008-000-10161-0] FX Research is supported by the Automotive Research Center, which is sponsored by the U.S. Army Tank Automotive Research, Development and Engineering Center (TARDEC). This research was also partially supported by the World Class University Program through the National Research Foundation of Korea (NRF) grant funded by the Ministry of Education, Science and Technology (Grant Number R32-2008-000-10161-0 in 2009). NR 44 TC 3 Z9 3 U1 0 U2 20 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1615-147X J9 STRUCT MULTIDISCIP O JI Struct. Multidiscip. Optim. PD FEB PY 2013 VL 47 IS 2 BP 175 EP 189 DI 10.1007/s00158-012-0833-1 PG 15 WC Computer Science, Interdisciplinary Applications; Engineering, Multidisciplinary; Mechanics SC Computer Science; Engineering; Mechanics GA 074HI UT WOS:000313803100002 ER PT J AU Collins, JL Peng, XQ Lee, R Witriol, A Pierre, Z Sciuto, AM AF Collins, Jennifer L. Peng, Xinqi Lee, Robyn Witriol, Alicia Pierre, Zdenka Sciuto, Alfred M. TI Determination of LCt(50)s in anesthetized rats exposed to aerosolized nerve agents SO TOXICOLOGY MECHANISMS AND METHODS LA English DT Article DE Chemical warfare nerve agents; aerosol; inhalation LCt(50) determination; acetylcholinesterase; anesthetized rodents ID ACETYLCHOLINESTERASE; STAGEWISE; TOXICITY; SOMAN; DRUGS; GB AB Nerve agents pose a threat to the respiratory tract with exposure that could result in acute compromised lung performance and death. The determination of toxicity by inhalation is important for the rational development of timely therapeutic countermeasures. This study was designed to deliver aerosolized dilute nerve agents in a dose-response manner to investigate the extent of lethality of nerve agents: soman, sarin, VX and VR. Male rats (240-270 g) were anesthetized intramuscularly with 10 mg/kg xylazine and 90 mg/kg ketamine. Following anesthesia, rats were intubated with a glass endotracheal tube (ET) and placed in a glove box. The ET was connected to a closed circuit nebulizer system (Aeroneb, Aerogen, Inc.) that delivered a particle size of < 2.0 mu m and was in series between the ventilator and the ET. Nerve agents were delivered by a small animal ventilator set for a volume of 2.5 mL x 60-80 breaths/min. VX or VR were nebulized and delivered in concentrations ranging from 6.25-800 mu g/kg over a 10-min exposure time period. Sarin (GB) or soman (GD), 6.5-1250 mu g/kg, were delivered in a similar manner. Lethality by inhalation occurred either during the 10-min exposure period or less than 15 min after the cessation of exposure. Survivors were euthanized at 24 h postexposure. LCt(50) estimates (+/- 95% confidence intervals [CIs]) were obtained from the sequential stage-wise experiments using the probit analysis. Probit analysis revealed that the LD50 for VX was 110.7 mu g/kg (CI: 73.5-166.7), VR 64.2 mu g/kg (CI: 42.1-97.8); soman (GD), 167 mu g/kg (CI: 90-310), and sarin (GB), 154 mu g/kg (CI: 98-242), respectively. Although VR is a structural isomer of VX, the compounds appear to be markedly different in terms of toxicity when delivered by aerosol. These relationships were converted to actual 10 min LCt(50) equivalents: VX = 632.2, VR = 367, GD = 954.3 and GB = 880 mg.min/m(3). Validation of exposure was verified by the determination of blood levels of acetylcholinesterase (AChE) across doses for the agent VR. C1 [Peng, Xinqi; Lee, Robyn; Witriol, Alicia; Pierre, Zdenka; Sciuto, Alfred M.] USA, Med Toxicol Branch, Analyt Toxicol Div, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Sciuto, AM (reprint author), USA, Med Toxicol Branch, Analyt Toxicol Div, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM alfred.mario.sciuto@us.army.mil FU Department of Defense and the Defense Threat Reduction Agency [3.F0007.RC.C.09] FX This project was supported by the Department of Defense and the Defense Threat Reduction Agency. 3.F0007.RC.C.09. The authors report no declarations of interest. NR 27 TC 3 Z9 5 U1 0 U2 23 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1537-6516 J9 TOXICOL MECH METHOD JI Toxicol. Mech. Methods PD FEB PY 2013 VL 23 IS 2 BP 127 EP 133 DI 10.3109/15376516.2012.730560 PG 7 WC Toxicology SC Toxicology GA 079DC UT WOS:000314149400010 PM 22978758 ER PT J AU Pinnick, RG Fernandez, E Rosen, JM Hill, SC Wang, Y Pan, YL AF Pinnick, R. G. Fernandez, E. Rosen, J. M. Hill, S. C. Wang, Y. Pan, Y. L. TI Fluorescence spectra and elastic scattering characteristics of atmospheric aerosol in Las Cruces, New Mexico, USA: Variability of concentrations and possible constituents and sources of particles in various spectral clusters SO ATMOSPHERIC ENVIRONMENT LA English DT Article DE Atmospheric aerosol particles; Fluorescence spectra; Elastic scattering; Clustered spectra; Integrated spectra; Time resolved ID SOUTHWESTERN UNITED-STATES; BLACK CARBON; SPECTROSCOPY; MATTER AB The UV-excited laser-induced-fluorescence (UV-LIF) spectra of single atmospheric particles and the three-band integrating-nephelometer elastic scattering of atmospheric aerosol were measured during four approximately 24-h periods on May 2007 in Las Cruces, New Mexico, USA. Aerosol scattering measurements in the nephelometer red channel (50-nm band centered at 700-nm) ranged from around 3-10 times the molecular (Rayleigh) scattering background. On average 22.8% of particles with size greater than about 1 gm diameter have fluorescence above a preset fluorescence threshold. A hierarchical cluster analysis indicates that most of the single-particle UV-LIF spectra fall into about 10 categories (spectral clusters) as found previously at other geographic sites (Pinnick et al., 2004; Pan et al., 2007). The clusters include spectra characteristic of various humic/fulvic acids, humic-like-substances (HULIS), chemically aged terpenes, fungal spores, polycyclic aromatic hydrocarbons, bacteria, cellulose/pollens, and mixtures of various organic carbon compounds. By far the most populated cluster category is similar to those of chemically aged terpenes/humic-materials; on average this population comprises about 62% of fluorescent particles. Clusters with spectra similar to that of some HULIS aerosol contain on average 10.0% of particles; those characteristic of some fungal spores (or perhaps mixtures of aromatic organic compounds) 8.4% of particles; bacteria-like spectra 1.6% of particles; and cellulose/pollen-like spectra 0.8% of particles. Measurements of fluorescent particles over relatively short (24 min) periods reveal that the concentrations of particles in the most populated clusters are highly correlated, suggesting that the particles populating them derive from the same region; these particles might be composed of crustal material coated with secondary organic carbon. On the other hand, concentrations of particles having cellulose-like spectra are generally uncorrelated with those in any other cluster. No clear distinction in fluorescent aerosol characteristics can be seen for different air mass trajectories arriving at the sampling site, suggesting that fluorescent aerosol particles are primarily of local origin. Integrations of the single-particle UV-LIF spectra over approximate 24 h time intervals reveal two broad peaks around 350 nm and 450 nm (for 263 nm excitation); the 450 nm peak is somewhat similar to that measured previously for water soluble organic carbon derived from aerosol collections. The 350 nm peak apparently has not been seen before in measurements of aerosol collections and may derive from non-soluble primary biological aerosol particles such as fungal spores. Further measurements are needed to investigate in more detail the generality of these results. Published by Elsevier Ltd. C1 [Pinnick, R. G.; Hill, S. C.; Wang, Y.; Pan, Y. L.] USA, Res Lab, Adelphi, MD 20783 USA. [Pinnick, R. G.; Fernandez, E.; Rosen, J. M.] New Mexico State Univ, Dept Phys, Las Cruces, NM 88003 USA. RP Pan, YL (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM yongle.pan.civ@mail.mil FU Defense Threat Reduction Agency under the Physical Science and Technology Basic Research Program; Army Research Laboratory mission funds FX This research was supported by the Defense Threat Reduction Agency under the Physical Science and Technology Basic Research Program and by Army Research Laboratory mission funds. We thank David L. Bones and Professor Sergey Nizkorodov for supplying their fluorescence spectral data on chemically-aged terpenes. NR 19 TC 15 Z9 15 U1 4 U2 52 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 J9 ATMOS ENVIRON JI Atmos. Environ. PD FEB PY 2013 VL 65 BP 195 EP 204 DI 10.1016/j.atmosenv.2012.09.020 PG 10 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA 074UV UT WOS:000313840500021 ER PT J AU Baer, LA Wu, X Tou, JC Johnson, E Wolf, SE Wade, CE AF Baer, L. A. Wu, X. Tou, J. C. Johnson, E. Wolf, S. E. Wade, C. E. TI Contributions of severe burn and disuse to bone structure and strength in rats SO BONE LA English DT Article DE Hindlimb unloading; Thermal injury; Femur; Mechanical bending; Micro-computed tomography ID SKELETAL-MUSCLE; INSULIN-RESISTANCE; GROWTH-HORMONE; BED REST; INJURY; OSTEOPOROSIS; MARKERS; EXPRESSION; DECREASES; TURNOVER AB Burn and disuse results in metabolic and bone changes associated with substantial and sustained bone loss. Such loss can lead to an increased fracture incidence and osteopenia. We studied the independent effects of burn and disuse on bone morphology, composition and strength, and microstructure of the bone alterations 14 days after injury. Sprague-Dawley rats were randomized into four groups: Sham/Ambulatory (SA), Burn/Ambulatory (BA), Sham/Hindlimb Unloaded (SH) and Burn/Hindlimb Unloaded (BH). Burn groups received a 40% total body surface area full-thickness scald burn. Disuse by hindlimb unloading was initiated immediately following injury. Bone turnover was determined in plasma and urine. Femur biomechanical parameters were measured by three-point bending tests and bone microarchitecture was determined by micro-computed tomography (uCT). On day 14, a significant reduction in body mass was observed as a result of burn, disuse and a combination of both. In terms of bone health, disuse alone and in combination affected femur weight, length and bone mineral content. Bending failure energy, an index of femur strength, was significantly reduced in all groups and maximum bending stress was lower when burn and disuse were combined. Osteocalcin was reduced in BA compared to the other groups, indicating influence of burn. The reductions observed in femur weight, BMC, biomechanical parameters and indices of bone formation are primarily responses to the combination of burn and disuse. These results offer insight into bone degradation following severe injury and disuse. (C) 2012 Elsevier Inc. All rights reserved. C1 [Baer, L. A.; Wu, X.; Wolf, S. E.; Wade, C. E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Baer, L. A.; Wade, C. E.] Univ Texas Hlth Sci Ctr Houston, Dept Surg, Houston, TX 77030 USA. [Baer, L. A.; Wade, C. E.] Ctr Translat Injury Res, Houston, TX 77030 USA. [Tou, J. C.] W Virginia Univ, Morgantown, WV 26506 USA. [Johnson, E.] MD Anderson Small Anim Imaging Facil, Houston, TX 77030 USA. [Wolf, S. E.] Univ Texas SW Med Ctr Dallas, Dept Surg, Dallas, TX 75390 USA. RP Baer, LA (reprint author), Univ Texas Hlth Sci Ctr Houston, Dept Surg, 6431 Fannin St,MSB 5-214, Houston, TX 77030 USA. EM lisa.baer@uth.tmc.edu OI Wolf, Steven/0000-0003-2972-3440 FU National Institutes of Health [1 R01 GM063120-04]; Technologies for Metabolic Monitoring (TMM)/Julia Weaver Fund; Congressionally Directed Program; NASA; Juvenile Diabetes Research Foundation And Combat Casualty Care Division United States Army Medical Research and Materiel Command FX This research was funded by the National Institutes of Health (1 R01 GM063120-04); the Technologies for Metabolic Monitoring (TMM)/Julia Weaver Fund, A Congressionally Directed Program Jointly Managed by the USA MRMC; NIH; NASA and the Juvenile Diabetes Research Foundation And Combat Casualty Care Division United States Army Medical Research and Materiel Command. The funding sources had no involvement in the study design, data collection, analysis, interpretation of the data, writing this manuscript or the decision to submit this article for publication. NR 41 TC 5 Z9 6 U1 0 U2 8 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 8756-3282 J9 BONE JI Bone PD FEB PY 2013 VL 52 IS 2 BP 644 EP 650 DI 10.1016/j.bone.2012.10.032 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 071PW UT WOS:000313607700015 PM 23142361 ER PT J AU Morrison, JJ McConnell, NJ Orman, JA Egan, G Jansen, JO AF Morrison, J. J. McConnell, N. J. Orman, J. A. Egan, G. Jansen, J. O. TI Rural and urban distribution of trauma incidents in Scotland SO BRITISH JOURNAL OF SURGERY LA English DT Article ID INJURED PATIENTS; SYSTEM; OUTCOMES; VOLUME; STATE AB Background: Trauma systems reduce mortality and improve functional outcomes from injury. Regional trauma networks have been established in several European regions to address longstanding deficiencies in trauma care. A perception of the geography and population distribution as challenging has delayed the introduction of a trauma system in Scotland. The characteristics of trauma incidents attended by the Scottish Ambulance Service were analysed, to gain a better understanding of the geospatial characteristics of trauma in Scotland. Methods: Data on trauma incidents collected by the Scottish Ambulance Service between November 2008 and October 2010 were obtained. Incident location was analysed by health board region, rurality and social deprivation. The results are presented as number of patients, average annual incidence rates and relative risks. Results: Of the 141 668 incidents identified, 72.1 per cent occurred in urban regions. The risk of being involved in an incident was similar across the most populous regions, and decreased slightly with increasing rurality. Social deprivation was associated with greater numbers and risk. A total of 53.1 per cent of patients were taken to a large general hospital, and 38.6 per cent to a teaching hospital; the distribution was similar for the subset of incidents involving patients with physiological derangements. Conclusion: The majority of trauma incidents in Scotland occur in urban and deprived areas. A regionalized system of trauma care appears plausible, although the precise configuration of such a system requires further study. Copyright (c) 2012 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. C1 [Morrison, J. J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham B15 2SQ, W Midlands, England. [McConnell, N. J.; Jansen, J. O.] Aberdeen Royal Infirm, Dept Surg, Aberdeen, Scotland. [McConnell, N. J.; Jansen, J. O.] Aberdeen Royal Infirm, Dept Intens Care Med, Aberdeen, Scotland. [Egan, G.] Scottish Ambulance Serv, Edinburgh, Midlothian, Scotland. [Morrison, J. J.; Orman, J. A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Orman, J. A.] Univ Texas Hlth Sci Ctr San Antonio, Dept Epidemiol & Biostat, San Antonio, TX 78229 USA. RP Morrison, JJ (reprint author), Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham B15 2SQ, W Midlands, England. EM jjmorrison@outlook.com OI Morrison, Jonathan/0000-0001-7462-8456 NR 29 TC 10 Z9 10 U1 1 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0007-1323 J9 BRIT J SURG JI Br. J. Surg. PD FEB PY 2013 VL 100 IS 3 BP 351 EP 359 DI 10.1002/bjs.8982 PG 9 WC Surgery SC Surgery GA 070SK UT WOS:000313531100009 PM 23184249 ER PT J AU Hammond, RT AF Hammond, Richard T. TI Electrodynamics and Radiation Reaction SO FOUNDATIONS OF PHYSICS LA English DT Article DE Radiation reaction; Self force ID RUNAWAY SOLUTIONS; FORCE AB The self force of electrodynamics is derived from a scalar field. The resulting equation of motion is free of all of the problems that plague the Lorentz Abraham Dirac equation. The age-old problem of a particle in a constant field is solved and the solution has intuitive appeal. C1 [Hammond, Richard T.] Univ N Carolina, Dept Phys, Chapel Hill, NC 27515 USA. [Hammond, Richard T.] Army Res Off, Res Triangle Pk, NC USA. RP Hammond, RT (reprint author), Univ N Carolina, Dept Phys, Chapel Hill, NC 27515 USA. EM rhammond@email.unc.edu NR 18 TC 6 Z9 6 U1 0 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0015-9018 J9 FOUND PHYS JI Found. Phys. PD FEB PY 2013 VL 43 IS 2 BP 201 EP 209 DI 10.1007/s10701-012-9687-z PG 9 WC Physics, Multidisciplinary SC Physics GA 074HD UT WOS:000313802600001 ER PT J AU Hamilton, JB Sandelowski, M Moore, AD Agarwal, M Koenig, HG AF Hamilton, Jill B. Sandelowski, Margarete Moore, Angelo D. Agarwal, Mansi Koenig, Harold G. TI "You Need a Song to Bring You Through": The Use of Religious Songs to Manage Stressful Life Events SO GERONTOLOGIST LA English DT Article ID QUALITATIVE CONTENT-ANALYSIS; OLDER AFRICAN-AMERICANS; MENTAL-HEALTH; INTEGRATIVE REMINISCENCE; DEPRESSIVE SYMPTOMS; SPIRITUALITY; THERAPY; ADULTS; INTERVENTION; PAIN AB Purpose: To explore in a sample of older African Americans how religious songs were used to cope with stressful life events and to explore the religious beliefs associated with these songs. Design and Methods: Sixty-five African American older adults residing in the Southeastern US participated in a qualitative descriptive study involving criterion sampling, open-ended semi-structured interviews, qualitative content analysis, and descriptive statistics. Results: Religion expressed through song was a coping strategy for participants experiencing stressful life events who described feelings of being comforted, strengthened, able to endure, uplifted, and able to find peace by turning to the types of religious songs described here. Five types of songs were used including those evoking Thanksgiving and Praise, Instructive, Memory of Forefathers, Communication with God, and Life after Death. Implications: Religious songs are an important form of religious expression important to the mental health of older African Americans. The incorporation of religious songs into spiritual care interventions might enhance the cultural relevance of mental health interventions in this population. C1 [Hamilton, Jill B.; Sandelowski, Margarete; Agarwal, Mansi] Univ N Carolina, Chapel Hill Sch Nursing, Chapel Hill, NC 27599 USA. [Moore, Angelo D.] USA, Tripler Army Med Ctr, Honolulu, HI USA. [Koenig, Harold G.] Duke Univ, Med Ctr, Durham, NC USA. RP Hamilton, JB (reprint author), Univ N Carolina, Chapel Hill Sch Nursing, CB 7460, Chapel Hill, NC 27599 USA. EM jhamilto@email.unc.edu RI Koenig, Harold/F-7379-2011 NR 61 TC 12 Z9 12 U1 1 U2 23 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0016-9013 J9 GERONTOLOGIST JI Gerontologist PD FEB PY 2013 VL 53 IS 1 BP 26 EP 38 DI 10.1093/geront/gns064 PG 13 WC Gerontology SC Geriatrics & Gerontology GA 071RV UT WOS:000313612800004 PM 22589023 ER PT J AU Cartagena, CM Schmid, KE Phillips, KL Tortella, FC Dave, JR AF Cartagena, Casandra M. Schmid, Kara E. Phillips, Katie L. Tortella, Frank C. Dave, Jitendra R. TI Changes in Apoptotic Mechanisms Following Penetrating Ballistic-Like Brain Injury SO JOURNAL OF MOLECULAR NEUROSCIENCE LA English DT Article DE Traumatic brain injury; Penetrating brain injury; Apoptosis ID NECROSIS-FACTOR-ALPHA; BCL-2 FAMILY-MEMBER; TRAUMATIC BRAIN; CELL-DEATH; NERVOUS-SYSTEM; RAT MODEL; NEUROPROTECTION; INFLAMMATION; INHIBITION; BARRIER AB We investigated apoptotic pathways in a model of severe traumatic brain injury, penetrating ballistic-like brain injury (PBBI). TUNEL staining identified increasing apoptosis within 24 h. From targeted arrays, 11 genes were identified for temporal mRNA evaluation. In addition, mRNA levels and enzyme activity for caspases 3, 8, and 9 were examined. In the death receptor-mediated apoptosis pathway, the relative quantities (RQs) of mRNA for tnfr1, fas, and tnf were upregulated while trail mRNA was downregulated. In the anti-apoptotic TNF-R2 pathway, tnfr2 and flip were upregulated while xiap was downregulated. These findings indicate that increases in tnf levels following injury are not only pro-apoptotic but may also signal competing anti-apoptotic mechanisms. For the mitochondria-mediated apoptosis pathway, RQs of anti-apoptotic factors bcl2a1d and birc3 were upregulated while both bcl2 and bax were downregulated. RQs for casp 3 and casp 8 increased while casp9 decreased. Enzymatic activity increased for caspases 3, 8, and 9. While multiple mechanisms promoting and inhibiting apoptosis are at play during the first week after a PBBI, the cumulative result remains increased apoptosis. The ability to understand and dissect these events will assist in the development and evaluation of treatments targeting apoptosis following severe brain injury. C1 [Cartagena, Casandra M.; Schmid, Kara E.; Phillips, Katie L.; Tortella, Frank C.; Dave, Jitendra R.] Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Dept Brain Trauma Neuroprotect & Neurorestorat, Silver Spring, MD 20910 USA. RP Cartagena, CM (reprint author), Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Dept Brain Trauma Neuroprotect & Neurorestorat, Silver Spring, MD 20910 USA. EM casandra.cartagena@us.army.mil; kara.schmid@us.army.mil; katie.phillips@amedd.army.mil; frank.c.tortella@us.army.mil; jit.dave@amedd.army.mil RI Dave, Jitendra/A-8940-2011 NR 34 TC 1 Z9 1 U1 0 U2 7 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA SN 0895-8696 J9 J MOL NEUROSCI JI J. Mol. Neurosci. PD FEB PY 2013 VL 49 IS 2 BP 301 EP 311 DI 10.1007/s12031-012-9828-z PG 11 WC Biochemistry & Molecular Biology; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA 070OW UT WOS:000313519900008 PM 22684621 ER PT J AU Alam, SM Liao, HX Tomaras, GD Bonsignori, M Tsao, CY Hwang, KK Chen, HY Lloyd, KE Bowman, C Sutherland, L Jeffries, TL Kozink, DM Stewart, S Anasti, K Jaeger, FH Parks, R Yates, NL Overman, RG Sinangil, F Berman, PW Pitisuttithum, P Kaewkungwal, J Nitayaphan, S Karasavva, N Rerks-Ngarm, S Kim, JH Michael, NL Zolla-Pazner, S Santra, S Letvin, NL Harrison, SC Haynes, BF AF Alam, S. Munir Liao, Hua-Xin Tomaras, Georgia D. Bonsignori, Mattia Tsao, Chun-Yen Hwang, Kwan-Ki Chen, Haiyan Lloyd, Krissey E. Bowman, Cindy Sutherland, Laura Jeffries, Thomas L., Jr. Kozink, Daniel M. Stewart, Shelley Anasti, Kara Jaeger, Frederick H. Parks, Robert Yates, Nicole L. Overman, R. Glenn Sinangil, Faruk Berman, Phillip W. Pitisuttithum, Punnee Kaewkungwal, Jaranit Nitayaphan, Sorachai Karasavva, Nicos Rerks-Ngarm, Supachai Kim, Jerome H. Michael, Nelson L. Zolla-Pazner, Susan Santra, Sampa Letvin, Norman L. Harrison, Stephen C. Haynes, Barton F. TI Antigenicity and Immunogenicity of RV144 Vaccine AIDSVAX Clade E Envelope Immunogen Is Enhanced by a gp120 N-Terminal Deletion SO JOURNAL OF VIROLOGY LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; BROADLY NEUTRALIZING ANTIBODIES; HUMAN MONOCLONAL-ANTIBODIES; PREVENT HIV-1 INFECTION; V1/V2 DOMAIN; BINDING INTERACTIONS; EFFICACY TRIAL; EPITOPES; GLYCOPROTEINS; MEMBRANE AB An immune correlates analysis of the RV144 HIV-1 vaccine trial revealed that antibody responses to the gp120 V1/V2 region correlated inversely with infection risk. The RV144 protein immunogens (A244-rp120 and MN-rgp120) were modified by an N-terminal 11-amino-acid deletion (Delta 11) and addition of a herpes simplex virus (HSV) gD protein-derived tag (gD). We investigated the effects of these modifications on gp120 expression, antigenicity, and immunogenicity by comparing unmodified A244 gp120 with both Delta 11 deletion and gD tag and with Delta 11 only. Analysis of A244 gp120, with or without Delta 11 or gD, demonstrated that the Delta 11 deletion, without the addition of gD, was sufficient for enhanced antigenicity to gp120 C1 region, conformational V2, and V1/V2 gp120 conformational epitopes. RV144 vaccinee serum IgGs bound more avidly to A244 gp120 Delta 11 than to the unmodified gp120, and their binding was blocked by C1, V2, and V1/V2 antibodies. Rhesus macaques immunized with the three different forms of A244 gp120 proteins gave similar levels of gp120 antibody titers, although higher antibody titers developed earlier in A244 Delta 11 gp120-immunized animals. Conformational V1/V2 monoclonal antibodies (MAbs) gave significantly higher levels of blocking of plasma IgG from A244 Delta 11 gp120-immunized animals than IgG from animals immunized with unmodified A244 gp120, thus indicating a qualitative difference in the V1/V2 antibodies induced by A244 Delta 11 gp120. These results demonstrate that deletion of N-terminal residues in the RV144 A244 gp120 immunogen improves both envelope antigenicity and immunogenicity. C1 [Alam, S. Munir; Liao, Hua-Xin; Tomaras, Georgia D.; Bonsignori, Mattia; Tsao, Chun-Yen; Hwang, Kwan-Ki; Chen, Haiyan; Lloyd, Krissey E.; Bowman, Cindy; Sutherland, Laura; Jeffries, Thomas L., Jr.; Kozink, Daniel M.; Stewart, Shelley; Anasti, Kara; Jaeger, Frederick H.; Parks, Robert; Yates, Nicole L.; Overman, R. Glenn; Pitisuttithum, Punnee; Haynes, Barton F.] Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC 27706 USA. [Sinangil, Faruk] Global Solut Infect Dis, San Francisco, CA USA. [Berman, Phillip W.] Univ Calif Santa Cruz, Santa Cruz, CA 95064 USA. [Kaewkungwal, Jaranit] Mahidol Univ, Fac Trop Med, Bangkok, Thailand. [Nitayaphan, Sorachai; Karasavva, Nicos] Armed Forces Res Inst Med Sci, Dept Retrovirol, Bangkok 10400, Thailand. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. [Kim, Jerome H.; Michael, Nelson L.] Walter Reed Army Inst Res, US Mil Res Program, Rockville, MD USA. [Zolla-Pazner, Susan] Vet Affairs New York Harbor Healthcare Syst, New York, NY USA. [Zolla-Pazner, Susan] NYU, Sch Med, Dept Pathol, New York, NY USA. [Santra, Sampa; Letvin, Norman L.] Harvard Univ, Beth Israel Deaconess Med Ctr, Dept Med, Sch Med, Boston, MA 02215 USA. [Harrison, Stephen C.] Harvard Univ, Sch Med, Boston Childrens Hosp, Boston, MA USA. [Harrison, Stephen C.] Howard Hughes Med Inst, Chevy Chase, MD USA. RP Alam, SM (reprint author), Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC 27706 USA. EM alam0004@mc.duke.edu; hayne002@mc.duke.edu RI Tomaras, Georgia/J-5041-2016 FU Bill & Melinda Gates Foundation; National Institutes of Allergy and Infectious Diseases, Division of AIDS, Department of Health and Human Sciences, through a U01-grant from the NIH, NIAID [AI067854]; NIH, NHLBI [HL59725]; Department of Veterans Affairs; U.S. Army Medical Research and Materiel Command [Y1-AI-2642-12]; National Institute of Allergy and Infectious Diseases; Henry M. Jackson Foundation for the Advancement of Military Medicine [W81XWH-07-2-0067]; U.S. Department of Defense [W81XWH-07-2-0067]; Fisher BioServices [FBS50035-15]; NYU [FBS50035-15] FX This study was supported in part by the Bill & Melinda Gates Foundation and Collaboration for AIDS Vaccine Discovery (CAVD) and CAVD-VIMC grants, by the National Institutes of Allergy and Infectious Diseases, Division of AIDS, Department of Health and Human Sciences, through a U01-grant from the NIH, NIAID, AI067854 (the Center for HIV/AIDS Vaccine Immunology), by NIH, NHLBI, HL59725, and by research funds from the Department of Veterans Affairs. This work was also supported in part by an Interagency Agreement (Y1-AI-2642-12) between the U.S. Army Medical Research and Materiel Command and the National Institute of Allergy and Infectious Diseases, by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the U.S. Department of Defense, and by a contract between Fisher BioServices and NYU (FBS50035-15). NR 45 TC 32 Z9 32 U1 1 U2 29 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD FEB PY 2013 VL 87 IS 3 BP 1554 EP 1568 DI 10.1128/JVI.00718-12 PG 15 WC Virology SC Virology GA 071AR UT WOS:000313558100024 PM 23175357 ER PT J AU Pegu, P Vaccari, M Gordon, S Keele, BF Doster, M Guan, YJ Ferrari, G Pal, R Ferrari, MG Whitney, S Hudacik, L Billings, E Rao, M Montefiori, D Tomaras, G Alam, SM Fenizia, C Lifson, JD Stablein, D Tartaglia, J Michael, N Kim, J Venzon, D Franchini, G AF Pegu, Poonam Vaccari, Monica Gordon, Shari Keele, Brandon F. Doster, Melvin Guan, Yongjun Ferrari, Guido Pal, Ranajit Ferrari, Maria Grazia Whitney, Stephen Hudacik, Lauren Billings, Erik Rao, Mangala Montefiori, David Tomaras, Georgia Alam, S. Munir Fenizia, Claudio Lifson, Jeffrey D. Stablein, Donald Tartaglia, Jim Michael, Nelson Kim, Jerome Venzon, David Franchini, Genoveffa TI Antibodies with High Avidity to the gp120 Envelope Protein in Protection from Simian Immunodeficiency Virus SIVmac251 Acquisition in an Immunization Regimen That Mimics the RV-144 Thai Trial SO JOURNAL OF VIROLOGY LA English DT Article ID PREVENT HIV-1 INFECTION; VACCINE EFFICACY TRIAL; RHESUS MACAQUES; INTEGRIN ALPHA(4)BETA(7); GAG/POL/NEF VACCINE; CHALLENGE EXPOSURE; SIV CHALLENGE; DOUBLE-BLIND; T-CELLS; B-CELL AB The recombinant canarypox vector, ALVAC-HIV, together with human immunodeficiency virus (HIV) gp120 envelope glycoprotein, has protected 31.2% of Thai individuals from HIV acquisition in the RV144 HIV vaccine trial. This outcome was unexpected, given the limited ability of the vaccine components to induce CD8(+)T-cell responses or broadly neutralizing antibodies. We vaccinated macaques with an immunization regimen intended to mimic the RV144 trial and exposed them intrarectally to a dose of the simian immunodeficiency virus SIVmac251 that transmits few virus variants, similar to HIV transmission to humans. Vaccination induced anti-envelope antibodies in all vaccinees and CD4(+) and CD8(+)T-cell responses. Three of the 11 macaques vaccinated with ALVAC-SIV/gp120 were protected from SIVmac251 acquisition, but the result was not significant. The remaining vaccinees were infected and progressed to disease. The magnitudes of vaccine-induced SIVmac251-specific T-cell responses and binding antibodies were not significantly different between protected and infected animals. However, sera from protected animals had higher avidity antibodies to gp120, recognized the variable envelope regions V1/V2, and reduced SIVmac251 infectivity in cells that express high levels of alpha(4)beta(7) integrins, suggesting a functional role of antibodies to V2. The current results emphasize the utility of determining the titer of repeated mucosal challenge in the preclinical evaluation of HIV vaccines. C1 [Pegu, Poonam; Vaccari, Monica; Gordon, Shari; Doster, Melvin; Fenizia, Claudio; Franchini, Genoveffa] NCI, Anim Models & Retroviral Vaccine Sect, NIH, Bethesda, MD 20892 USA. [Keele, Brandon F.; Lifson, Jeffrey D.] SAIC Frederick Inc, AIDS & Canc Virus Program, Frederick Natl Lab Canc Res, Frederick, MD USA. [Guan, Yongjun] Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA. [Guan, Yongjun] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA. [Ferrari, Guido; Montefiori, David; Tomaras, Georgia; Alam, S. Munir] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA. [Pal, Ranajit; Ferrari, Maria Grazia; Whitney, Stephen; Hudacik, Lauren] Adv Biosci Labs, Rockville, MD USA. [Billings, Erik; Rao, Mangala] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Stablein, Donald] EMMES Corp, Rockville, MD USA. [Tartaglia, Jim] Sanofi Pasteur Inc, Swiftwater, PA USA. [Venzon, David] NCI, Biostat & Data Management Sect, Bethesda, MD 20892 USA. RP Franchini, G (reprint author), NCI, Anim Models & Retroviral Vaccine Sect, NIH, Bethesda, MD 20892 USA. EM franchig@mail.nih.gov RI Ferrari, Guido/A-6088-2015; Tomaras, Georgia/J-5041-2016 FU NIH; NCI [HHSN2662004000088C] FX This research was supported by the Intramural Research Program of the NIH, NCI, and under NCI contract HHSN2662004000088C. NR 56 TC 51 Z9 51 U1 4 U2 15 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD FEB PY 2013 VL 87 IS 3 BP 1708 EP 1719 DI 10.1128/JVI.02544-12 PG 12 WC Virology SC Virology GA 071AR UT WOS:000313558100037 PM 23175374 ER PT J AU Morrison, JJ Oh, J DuBose, JJ O'Reilly, DJ Russell, RJ Blackbourne, LH Midwinter, MJ Rasmussen, TE AF Morrison, Jonathan J. Oh, John DuBose, Joseph J. O'Reilly, David J. Russell, Robert J. Blackbourne, Lorne H. Midwinter, Mark J. Rasmussen, Todd E. TI En-Route Care Capability From Point of Injury Impacts Mortality After Severe Wartime Injury SO ANNALS OF SURGERY LA English DT Article DE casualty evacuation; combat injury; medical evacuation; trauma; wartime injury ID EMERGENCY MEDICAL-SERVICES; COMBAT CASUALTY CARE; SURVIVAL; TRAUMA; WAR; BATTLEFIELD; AFGHANISTAN; DEATH AB Objective: The objective of this study is to characterize modern point-of-injury (POI) en-route care platforms and to compare mortality among casualties evacuated with conventional military retrieval (CMR) methods to those evacuated with an advanced medical retrieval (AMR) capability. Background: Following a decade of war in Afghanistan, the impact of en-route care capabilities from the POI on mortality is unknown. Methods: Casualties evacuated from POI to one level III facility in Afghanistan (July 2008 March 2012) were identified from UK and US trauma registries. Groups comprised those evacuated by a medically qualified provider-led, AMR and those by a medic-led CMR capability. Outcomes were compared per incremental Injury Severity Score (ISS) bins. Results: Most casualties (n = 1054; 61.2%) were in the low-ISS (1-15) bracket in which there was no difference in en-route care time or mortality between AMR and CMR. Casualties in the mid-ISS bracket (16-50) (n = 583; 33.4%) experienced the same median en-route care time (minutes) on AMR and CMR platforms [78 (58) vs 75 (93); P = 0.542] although those on AMR had shorter time to operation [110 (95) vs 117 (126); P < 0.001]. In this mid-ISS bracket, mortality was lower in the AMR than in the CMR group (12.2% vs 18.2%; P = 0.035). In the high-ISS category (51-75) (n = 75; 4.6%), time to operation was lower in the AMR than the CMR group (66 +/- 77 vs 113 +/- 122; P = 0.013) but there was no difference in mortality. Conclusions: This study characterizes en-route care capabilities from POI in modern combat. Conventional platforms are effective in most casualties with low injury severity. However, a definable injury severity exists for which evacuation with an AMR capability is associated with improved survival. C1 [Morrison, Jonathan J.; Blackbourne, Lorne H.; Rasmussen, Todd E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Morrison, Jonathan J.; O'Reilly, David J.; Midwinter, Mark J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Oh, John] Landstuhl Reg Med Ctr, Landstuhl, Germany. [DuBose, Joseph J.] R Adams Cowley Shock Trauma Ctr, C STARS Baltimore, Baltimore, MD USA. [Russell, Robert J.] Royal Ctr Def Med, Acad Dept Mil Emergency Med, Birmingham, W Midlands, England. [Rasmussen, Todd E.] Sci & Technol Sect, Med Deployment Wing 59, Lackland AFB, TX USA. [Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. RP Rasmussen, TE (reprint author), USA, Inst Surg Res, San Antonio, TX 78234 USA. EM todd.rasmussen@amedd.army.mil RI Midwinter, Mark/P-6264-2015; OI Midwinter, Mark/0000-0003-1836-7137; Morrison, Jonathan/0000-0001-7462-8456 FU Office of the US Air Force Surgeon General FX This work was supported by the Office of the US Air Force Surgeon General and was created in the performance of a contract with the Air Force Medical Support Agency. The viewpoints expressed in this article are those of the authors and do not reflect the official position of the US Department of Defense or the UK Defence Medical Service. NR 24 TC 30 Z9 31 U1 2 U2 11 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-4932 J9 ANN SURG JI Ann. Surg. PD FEB PY 2013 VL 257 IS 2 BP 330 EP 334 DI 10.1097/SLA.0b013e31827eefcf PG 5 WC Surgery SC Surgery GA 068IX UT WOS:000313361300023 PM 23291661 ER PT J AU Ouattara, A Takala-Harrison, S Thera, MA Coulibaly, D Niangaly, A Saye, R Tolo, Y Dutta, S Heppner, DG Soisson, L Diggs, CL Vekemans, J Cohen, J Blackwelder, WC Dube, T Laurens, MB Doumbo, OK Plowe, CV AF Ouattara, Amed Takala-Harrison, Shannon Thera, Mahamadou A. Coulibaly, Drissa Niangaly, Amadou Saye, Renion Tolo, Youssouf Dutta, Sheetij Heppner, D. Gray Soisson, Lorraine Diggs, Carter L. Vekemans, Johan Cohen, Joe Blackwelder, William C. Dube, Tina Laurens, Matthew B. Doumbo, Ogobara K. Plowe, Christopher V. TI Molecular Basis of Allele-Specific Efficacy of a Blood-Stage Malaria Vaccine: Vaccine Development Implications SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE Malaria; Plasmodium falciparum; apical membrane antigen 1; AMA1; vaccine trial; allele-specific efficacy; cluster 1 loop ID APICAL MEMBRANE ANTIGEN-1; PLASMODIUM-FALCIPARUM; ANTIBODY; TRIAL; RESPONSES; POLYMORPHISMS; PROTECTION; DIVERSITY; SELECTION; RESIDUE AB The disappointing efficacy of blood-stage malaria vaccines may be explained in part by allele-specific immune responses that are directed against polymorphic epitopes on blood-stage antigens. FMP2.1/AS02(A), a blood-stage candidate vaccine based on apical membrane antigen 1 (AMA1) from the 3D7 strain of Plasmodium falciparum, had allele-specific efficacy against clinical malaria in a phase II trial in Malian children. We assessed the cross-protective efficacy of the malaria vaccine and inferred which polymorphic amino acid positions in AMA1 were the targets of protective allele-specific immune responses. FMP2.1/AS02(A) had the highest efficacy against AMA1 alleles that were identical to the 3D7 vaccine-type allele at 8 highly polymorphic amino acid positions in the cluster 1 loop (c1L) but differed from 3D7 elsewhere in the molecule. Comparison of the incidence of vaccine-type alleles before and after vaccination in the malaria vaccine and control groups and examination of the patterns of allele change at polymorphic positions in consecutive malaria episodes suggest that the highly polymorphic amino acid position 197 in c1L was the most critical determinant of allele-specific efficacy. These results indicate that a multivalent AMA1 vaccine with broad efficacy could include only a limited set of key alleles of this extremely polymorphic antigen. C1 [Ouattara, Amed; Thera, Mahamadou A.; Coulibaly, Drissa; Niangaly, Amadou; Saye, Renion; Tolo, Youssouf; Doumbo, Ogobara K.] Univ Sci Tech & Technol, Malaria Res & Training Ctr, Bamako, Mali. [Ouattara, Amed; Takala-Harrison, Shannon; Blackwelder, William C.; Laurens, Matthew B.; Plowe, Christopher V.] Univ Maryland, Sch Med, Howard Hughes Med Inst, Ctr Vaccine Dev, Baltimore, MD 21201 USA. [Dutta, Sheetij; Heppner, D. Gray] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. [Dube, Tina] EMMES, Rockville, MD USA. [Soisson, Lorraine; Diggs, Carter L.] US Agcy Int Dev, Malaria Vaccine Dev Program, Washington, DC 20523 USA. [Vekemans, Johan; Cohen, Joe] GlaxoSmithKline Biol, Rixensart, Belgium. RP Plowe, CV (reprint author), Univ Maryland, Sch Med, Howard Hughes Med Inst, Ctr Vaccine Dev, 685 W Baltimore St,HSF1-480, Baltimore, MD 21201 USA. EM cplowe@medicine.umaryland.edu RI Laurens, Matthew/E-7293-2013 OI Laurens, Matthew/0000-0003-3874-581X FU National Institute of Allergy and Infectious Diseases [N01AI85346, U19AI065683]; Fogarty International Center of the National Institutes of Health [D43TW001589]; US Department of Defense [W81XWH-06-1-0427]; US Agency for International Development [W81XWH-06-1-0427]; University of Maryland Multidisciplinary Clinical Research Career Development Program (NIH) [K12RR023250] FX This work was supported by the National Institute of Allergy and Infectious Diseases (contract N01AI85346 and cooperative agreement U19AI065683), the Fogarty International Center of the National Institutes of Health (grant D43TW001589), both the US Department of Defense and US Agency for International Development (contract W81XWH-06-1-0427), the Howard Hughes Medical Institute and the Doris Duke Charitable Foundation (support for training and genetics analysis), and the University of Maryland Multidisciplinary Clinical Research Career Development Program (NIH award K12RR023250 to S. T.-H.). NR 28 TC 32 Z9 33 U1 2 U2 25 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD FEB 1 PY 2013 VL 207 IS 3 BP 511 EP 519 DI 10.1093/infdis/jis709 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 066JH UT WOS:000313216300020 PM 23204168 ER PT J AU Singer, GP Hearn, AR Chapman, ED Peterson, ML LaCivita, PE Brostoff, WN Bremner, A Klimley, AP AF Singer, Gabriel P. Hearn, Alex R. Chapman, Eric D. Peterson, Matthew L. LaCivita, Peter E. Brostoff, William N. Bremner, Allison Klimley, A. P. TI Interannual variation of reach specific migratory success for Sacramento River hatchery yearling late-fall run Chinook salmon (Oncorhynchus tshawytscha) and steelhead trout (Oncorhynchus mykiss) SO ENVIRONMENTAL BIOLOGY OF FISHES LA English DT Article DE Steelhead trout; Chinook salmon; Telemetry; Sacramento River; Migratory success; San Francisco Estuary ID LOWER SNAKE; SURVIVAL; CALIFORNIA; PROBABILITIES; ESTUARY; STOCKS; DELTA; TIME AB The release of hatchery reared salmonid smolts is a common management tool aimed at enhancing depleted wild stocks and maintaining fisheries throughout Northern California and the Pacific Northwest. In the Sacramento River watershed, smolts must migrate through the river, delta and estuary in order to successfully reach the Pacific Ocean. Migration success (success defined as apparent survival from one monitor location to another) may vary between species, year and habitat. We released 500 late-fall run Chinook salmon and 500 steelhead smolts in 2009 and 2010 in the Sacramento River (river kilometer 207). Each smolt was implanted with a coded ultrasonic tag, which was detected by an array of over 300 underwater receiver stations deployed throughout the system. Less than 25 % of fish migrated successfully to the Pacific Ocean in both years. We found that reach specific success was greater in the Delta in 2009 (> 60 %) than in 2010 (< 33 %), whereas this pattern was reversed in the Bay (< 57 % in 2009, > 75 % in 2010). Identifying the location, timing and causes of smolt mortality can lead to improved management of the resource. C1 [Singer, Gabriel P.; Hearn, Alex R.; Chapman, Eric D.; Peterson, Matthew L.; Klimley, A. P.] Univ Calif Davis, Biotelemetry Lab, Dept Wildlife Fish & Conservat Biol, Davis, CA 95616 USA. [LaCivita, Peter E.; Brostoff, William N.; Bremner, Allison] USA, Corps Engineers, San Francisco, CA 94103 USA. RP Singer, GP (reprint author), Univ Calif Davis, Biotelemetry Lab, Dept Wildlife Fish & Conservat Biol, 1 Shields Ave, Davis, CA 95616 USA. EM gsinger@ucdavis.edu FU San Francisco Bay Long Term Management Study through the San Francisco District of the United States Army Corps of Engineers FX Funding for this project was provided by the San Francisco Bay Long Term Management Study through the San Francisco District of the United States Army Corps of Engineers. This project could not have been completed without the help and support of the following people: Ethan Mora, Mike Thomas, Phil Sandstrom, Cyril Michel, Arnold Ammann, Kurtis Brown, Scott Hamelburg, David Woodbury and members of the California Fish Tracking Consortium. NR 36 TC 7 Z9 7 U1 3 U2 17 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0378-1909 J9 ENVIRON BIOL FISH JI Environ. Biol. Fishes PD FEB PY 2013 VL 96 IS 2-3 BP 363 EP 379 DI 10.1007/s10641-012-0037-y PG 17 WC Ecology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA 064FU UT WOS:000313059000019 ER PT J AU Moussa, HM Melanson, MA AF Moussa, Hanna M. Melanson, Mark A. TI TRANSLATION OF DOSE COEFFICIENTS FROM ICRP 53 TO ICRP 80 SO HEALTH PHYSICS LA English DT Article DE P-33; biokinetics; dose equivalent; effective dose; dose; absorbed AB The effective dose coefficients tabulated in Publication 80 of the International Commission on Radiological Protection (ICRP) for the radiopharmaceuticals addressed earlier in ICRP Publication 53 are based on the tissue weighting factors of ICRP Publication 60. Presumably these values are derived from the tissue dose coefficients tabulated in Publication 53; however, no details regarding their derivation are provided. The tissue weighting factors of Publication 60 explicitly address tissue for which no dose coefficients were tabulated in Publication 53; for example, esophagus and a number of tissues comprising the remainder. In the absence of guidance, the authors have defined a set of rules for the translation and have undertaken an effort to derive the effective dose coefficients of Publication 80 starting with the organ/tissue dose coefficient of Publication 53. Health Phys. 104(2): 224-226; 2013 C1 [Moussa, Hanna M.] Texas Tech Univ, Coll Human Sci, Lubbock, TX 79409 USA. [Melanson, Mark A.] USA, Publ Hlth Command, ATTN MCHB TS OHP, Aberdeen Proving Ground, MD 21010 USA. RP Moussa, HM (reprint author), Texas Tech Univ, Coll Human Sci, 1301 Akron,POB 41162, Lubbock, TX 79409 USA. EM hanna.moussa@ttu.edu NR 6 TC 0 Z9 1 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0017-9078 EI 1538-5159 J9 HEALTH PHYS JI Health Phys. PD FEB PY 2013 VL 104 IS 2 BP 224 EP 226 DI 10.1097/HP.0b013e3182758035 PG 3 WC Environmental Sciences; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA 064VV UT WOS:000313104400013 PM 23274826 ER PT J AU Ganesan, A Krantz, EM Hullsiek, KH Riddle, MS Weintrob, AC Lalani, T Okulicz, JF Landrum, M Agan, B Whitman, TJ Ross, MJ Crum-Cianflone, NF AF Ganesan, A. Krantz, E. M. Hullsiek, K. Huppler Riddle, M. S. Weintrob, A. C. Lalani, T. Okulicz, J. F. Landrum, M. Agan, B. Whitman, T. J. Ross, M. J. Crum-Cianflone, N. F. CA Infect Dis Clinical Res Program TI Determinants of incident chronic kidney disease and progression in a cohort of HIV-infected persons with unrestricted access to health care SO HIV MEDICINE LA English DT Article DE baseline CD4 count; ethnicity; highly active antiretroviral therapy; HIV infection; kidney disease; socioeconomic status ID STAGE RENAL-DISEASE; GLOMERULAR-FILTRATION-RATE; ACTIVE ANTIRETROVIRAL THERAPY; ATHEROSCLEROSIS RISK; RACIAL-DIFFERENCES; NEPHROPATHY; SPECTRUM; RECOMMENDATIONS; ASSOCIATION; COMMUNITIES AB Objectives As socioeconomic factors may impact the risk of chronic kidney disease (CKD), we evaluated the incidence and risk factors of incident CKD among an HIV-infected cohort with universal access to health care and minimal injecting drug use (IDU). Methods Incident CKD was defined as an estimated glomerular filteration rate (eGFR) <60?ml/min/1.73?m2 for =?90 days. eGFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Rates were calculated per 1000 person-years (PY). Associations with outcomes were assessed using two separate Cox proportional hazard models, adjusting for baseline and time-updated covariates. Results Among 3360 participants [median age 29 years; 92% male; 44% African American (AA)] contributing 23?091 PY of follow-up, 116 developed incident CKD [5.0/1000 PY; 95% confidence interval (CI) 4.26.0/1000 PY]. The median first eGFR value was 97.0?mL/min/1.73?m2 [interquartile range (IQR) 85.3110.1?mL/min/1.73?m2]. Baseline factors associated with CKD included older age, lower CD4 count at HIV diagnosis [compared with CD4 count =?500 cells/mu L, hazard ratio (HR) 2.1 (95% CI 1.23.8) for CD4 count 350499 cells/mu L; HR 3.6 (95% CI 2.06.3) for CD4 count 201349 cells/mu L; HR 4.3 (95% CI 2.09.4) for CD4 count =?200 cells/mu L], and HIV diagnosis in the pre-highly active antiretroviral therapy (HAART) era. In the time-updated model, low nadir CD4 counts, diabetes, hepatitis B, hypertension and less HAART use were also associated with CKD. AA ethnicity was not associated with incident CKD in either model. Conclusions The low incidence of CKD and the lack of association with ethnicity observed in this study may in part be attributable to unique features of our cohort such as younger age, early HIV diagnosis, minimal IDU, and unrestricted access to care. Lower baseline CD4 counts were significantly associated with incident CKD, suggesting early HIV diagnosis and timely introduction of HAART may reduce the burden of CKD. C1 [Ganesan, A.; Krantz, E. M.; Hullsiek, K. Huppler; Weintrob, A. C.; Lalani, T.; Okulicz, J. F.; Landrum, M.; Agan, B.; Whitman, T. J.; Crum-Cianflone, N. F.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Ganesan, A.] Natl Naval Med Ctr, Div Infect Dis, Bethesda, MD 20889 USA. [Krantz, E. M.; Hullsiek, K. Huppler] Univ Minnesota, Minneapolis, MN USA. [Weintrob, A. C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Lalani, T.] USN, Med Ctr Portsmouth, Portsmouth, VA USA. [Okulicz, J. F.; Landrum, M.] San Antonio Mil Med Ctr, San Antonio, TX USA. [Ross, M. J.] Mt Sinai Sch Med, New York, NY USA. [Crum-Cianflone, N. F.] USN, San Diego Med Ctr, San Diego, CA 92152 USA. [Crum-Cianflone, N. F.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. RP Ganesan, A (reprint author), Natl Naval Med Ctr, Div Infect Dis, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM anuradha.ganesan@med.navy.mil OI Polis, Michael/0000-0002-9151-2268; Agan, Brian/0000-0002-5114-1669 FU Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) programme executed through the Uniformed Services University of the Health Sciences [IDCRP-015]; National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [Y1-AI-5072] FX We would like to thank the participants and their caregivers, without whom none of this work would be possible. We would also like to thank the research coordinators and support staff who have diligently worked on the Department of Defense HIV Natural History Study, as well as the members of the Infectious Disease Clinical Research Program HIV Working Group, listed in the Appendix. Support for this work (IDCRP-015) was provided by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) programme executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. NR 42 TC 8 Z9 8 U1 0 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1464-2662 J9 HIV MED JI HIV Med. PD FEB PY 2013 VL 14 IS 2 BP 65 EP 76 DI 10.1111/j.1468-1293.2012.01036.x PG 12 WC Infectious Diseases SC Infectious Diseases GA 063KV UT WOS:000312998300001 PM 22808988 ER PT J AU Yang, Y Liou, WW Sheng, J Gorsich, D Arepally, S AF Yang, Yang Liou, William W. Sheng, James Gorsich, David Arepally, Sudhakar TI Shock wave impact simulation of a vehicle occupant using fluid/structure/dynamics interactions SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Blast wave; Fluid-structure interactions; Vehicle occupant safety ID PLATES AB Ground vehicles subjected to blast can result in vehicle movements and occupant injuries. The engineering mechanisms involved in such blasts include fluid dynamics, solid dynamics, and multi-body dynamics. This paper describes a parallel computer simulation methodology that can be applied to couple the structural deformation prediction of a ground vehicle system and the associated occupant kinematics during a blast event. Generic box and dummy models were used in the demonstration of this newly-developed methodology. The generic system structure consists of an outer cube representing a vehicle armor structure, and a dummy representing a crew member in a ground vehicle. Simulation results for different cases include free air blast wave propagation, blast on a metal plate and over a hemispherical dome, and blast wave interaction with a vehicle and its occupant inside. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Yang, Yang; Liou, William W.] Western Michigan Univ, Kalamazoo, MI 49008 USA. [Sheng, James; Gorsich, David; Arepally, Sudhakar] USA, RDECOM, TARDEC, Warren, MI 48397 USA. RP Yang, Y (reprint author), Western Michigan Univ, Kalamazoo, MI 49008 USA. EM yang.yang@wmich.edu RI Yang, Yang/A-2499-2011 OI Yang, Yang/0000-0002-7989-2843 FU U.S. Army TACOM Life Cycle Command through Mississippi State University [W56HZV-08-C-0236] FX This material is based upon work supported by the U.S. Army TACOM Life Cycle Command under Contract No. W56HZV-08-C-0236, through a subcontract with Mississippi State University, and was performed for the Simulation Based Reliability and Safety (SimBRS) research program. Any opinions, findings and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the U.S. Army TACOM Life Cycle Command. NR 23 TC 1 Z9 3 U1 0 U2 25 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD FEB PY 2013 VL 52 BP 11 EP 22 DI 10.1016/j.ijimpeng.2012.09.002 PG 12 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 056QK UT WOS:000312506000002 ER PT J AU Ainsworth, CR Pamplin, JC Allen, DA Linfoot, JA Chung, KK AF Ainsworth, Craig R. Pamplin, Jeremy C. Allen, David A. Linfoot, John A. Chung, Kevin K. TI A bedside communication tool did not improve the alignment of a multidisciplinary team's goals for intensive care unit patients SO JOURNAL OF CRITICAL CARE LA English DT Article DE Goals; Multi-disciplinary; Communications; Process improvement; Intensive care ID MEDICAL ERROR; SAFETY; EVENTS AB Purpose: Establishing well-understood daily patient care goals should improve healthcare team (HCT) communication, reduce errors, and improve patient outcomes. The purpose of this study was to test the hypothesis that implementation of a daily goals "Door Communication Card" (DCC) would improve goal alignment between members of the HCT. Methods: As part of a process improvement project, HCT members listed their top care goals for a patient on a given day. After initial data collection, DCCs were placed on patients' doors. Anyone was allowed to write on the card, but the "official" daily goals were recorded during multidisciplinary rounds. One month after introduction of the DCC, HCT members were re-queried about their patients' care goals. Three reviewers independently compared goals and assessed their alignment before and after implementation of the DCC. We collected goals over a 4-month period and selected 5 random days before and after intervention for assessment. Results: The goal alignment among HCT members was low before and did not improve after intervention (Attending-to-Nurse 55% vs 38%, P = .02; Attending-to-Resident 60% vs 54%, P = .43; Attending-to-Primary 35% vs 28%, P = .45; Nurse-to-Attending 52% vs 36%, P = .03; Nurse-to-Resident 55% vs 38%, P = .04; Nurse-to-Primary 37% vs 27%, P = .36; Resident-to-Attending 59% vs 54%, P = .4; Resident-to-Nurse 56% vs 40%, P = .05; Resident-to-Primary 36% vs 24%, P = .16; Primary-to-Attending 34% vs 42%, P = .44; Primary-to-Nurse 42% vs 35%, P = .6; Primary-to-Resident 32% vs 34%, P = .8). Conclusions: Alignment of daily patient care goals among HCT members is low overall and did not improve after implementing a DCC available to all team members. Further study to elucidate the mechanism by which daily goals forms improve patient care is required. Published by Elsevier Inc. C1 [Ainsworth, Craig R.] Walter Reed Natl Mil Med Ctr, Bethesda, MD 20889 USA. [Pamplin, Jeremy C.; Linfoot, John A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Allen, David A.; Chung, Kevin K.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Ainsworth, CR (reprint author), 16573 Sioux Lane, Gaithersburg, MD 20878 USA. NR 16 TC 1 Z9 1 U1 1 U2 10 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0883-9441 J9 J CRIT CARE JI J. Crit. Care PD FEB PY 2013 VL 28 IS 1 AR 112.e7 DI 10.1016/j.jcrc.2012.09.006 PG 7 WC Critical Care Medicine SC General & Internal Medicine GA 062UY UT WOS:000312949700024 PM 23159135 ER PT J AU McAllister, QP Gillespie, JW VanLandingham, MR AF McAllister, Quinn P. Gillespie, John W., Jr. VanLandingham, Mark R. TI The influence of surface microstructure on the scratch characteristics of Kevlar fibers SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID ATOMIC-FORCE MICROSCOPY; POLY(PARA-PHENYLENE TEREPHTHALAMIDE) FIBERS; POLY(P-PHENYLENE TEREPHTHALAMIDE); BIOPOLYMER FIBERS; ARAMID FABRICS; POLYMER; DEFORMATION; RESISTANCE; FRICTION; COATINGS AB In this work, nanoindentation and nanoscratching experiments are combined with atomic force microscopy to investigate the relationships between contact geometry, apparent friction, and deformation modes of two grades of Kevlar (R) (Dupont) fiber-Kevlar KM2 and Kevlar 49. Changes in the relative angle between the scratching probe and the fiber surface, often termed as the attack angle, result in changes in deformation mode, which correlate with the changes in the apparent friction. As attack angle increases, the observed deformation modes of the fiber surface change from a smoothing of the surface, often termed as ironing, to fibrillation, in which the fibrils break and coalesce in front of the progressing probe. A mixture of these two modes occurs at intermediate attack angles. When fibrillation occurs, material pile-up forms in front of the progressing probe. This pile-up introduces an additional component to the frictional response that is largely responsible for an increase in apparent friction with an increasing attack angle and/or scratch length. The level of friction associated with fibrillation is measured to be up to approximately three times higher than previously reported for Kevlar yarn-yarn friction. Fibrillation of Kevlar KM2 occurs at larger attack angles as compared to Kevlar 49, which is believed to be related to a near-surface region of reduced modulus and hardness previously observed in KM2 fibers. A detailed discussion of the measured response is given based on the interactions between the scratching probe and the fibrillar network and the resulting deformation mechanisms. C1 [McAllister, Quinn P.; Gillespie, John W., Jr.] Univ Delaware, Ctr Composite Mat, Dept Mat Sci & Engn, Newark, DE 19716 USA. [VanLandingham, Mark R.] USA, Mat & Mfg Sci Div, Weap & Mat Res Directorate, Res Lab,ATTN RDRL WMM B, Aberdeen, MD 21005 USA. RP Gillespie, JW (reprint author), Univ Delaware, Ctr Composite Mat, Dept Mat Sci & Engn, Newark, DE 19716 USA. EM mcallq@udel.edu; gillespi@udel.edu FU Army Research Laboratory [W911NF-06-2-0011] FX QM and JWG gratefully acknowledge the sponsorship by the Army Research Laboratory under cooperative agreement W911NF-06-2-0011. The views and conclusions contained in this paper should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes not withstanding any copyright notation herein. NR 47 TC 2 Z9 2 U1 3 U2 70 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD FEB PY 2013 VL 48 IS 3 BP 1292 EP 1302 DI 10.1007/s10853-012-6872-6 PG 11 WC Materials Science, Multidisciplinary SC Materials Science GA 062FO UT WOS:000312904900038 ER PT J AU Fernandez, S Cromer, LD Borntrager, C Swopes, R Hanson, RF Davis, JL AF Fernandez, Shantel Cromer, Lisa DeMarni Borntrager, Cameo Swopes, Rachael Hanson, Rochelle F. Davis, Joanne L. TI A Case Series: Cognitive-Behavioral Treatment (Exposure, Relaxation, and Rescripting Therapy) of Trauma-Related Nightmares Experienced by Children SO CLINICAL CASE STUDIES LA English DT Article DE sleep problems; dreams; posttraumatic stress; treatment ID POSTTRAUMATIC-STRESS-DISORDER; RANDOMIZED CLINICAL-TRIAL; SCHOOL-AGED CHILDREN; IMAGERY REHEARSAL; SLEEP DISORDERS; ANXIETY; INSTRUMENT; DEPRESSION; CHILDHOOD; SYMPTOMS AB Two case studies are presented to demonstrate that children who experience trauma-related nightmares may benefit from cognitive-behavioral therapy for this sleep problem. The treatment was adapted from the empirically supported adult treatment for chronic trauma-related nightmares: exposure, relaxation, and rescripting therapy (ERRT). Pretreatment and posttreatment nightmare frequency and severity were measured in addition to subjective nightmare-related distress, behavioral problems, sleep quality and quantity, and symptoms of posttraumatic stress disorder (PTSD), anxiety, and depression. Improvement in nightmare and sleep disturbance frequencies were found as well as reductions in parents' reports of child behavior problems. This study provides preliminary support for the use of ERRT with children. C1 [Fernandez, Shantel] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Cromer, Lisa DeMarni; Swopes, Rachael; Davis, Joanne L.] Univ Tulsa, Tulsa, OK 74104 USA. [Borntrager, Cameo] Univ Montana, Missoula, MT 59812 USA. [Hanson, Rochelle F.] Med Univ S Carolina, Charleston, SC USA. RP Fernandez, S (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM shantel.fernandez@us.army.mil NR 56 TC 2 Z9 2 U1 1 U2 7 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1534-6501 EI 1552-3802 J9 CLIN CASE STUD JI Clin. Case Stud. PD FEB PY 2013 VL 12 IS 1 BP 39 EP 59 DI 10.1177/1534650112462623 PG 21 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA AW9OL UT WOS:000346586800003 ER PT J AU Muramatsu, RS AF Muramatsu, Russ S. TI Untitled SO MILITARY MEDICINE LA English DT Letter C1 Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Muramatsu, RS (reprint author), Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD FEB PY 2013 VL 178 IS 2 BP IV EP IV PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA AN7TW UT WOS:000340804900002 PM 23495453 ER PT J AU Jones, DE Jones, F Suttinger, L Toler, A Hammond, P Medina, S AF Jones, David E. Jones, Franca Suttinger, Laura Toler, Ayessa Hammond, Patricia Medina, Steven TI Placement of Combat Stress Teams in Afghanistan: Reducing Barriers to Care SO MILITARY MEDICINE LA English DT Editorial Material AB This article describes the medical planning process whereby combat stress and mental health clinicians were placed at Forward Operating Bases in southern and western Afghanistan during a period of intensive surge operations in 2009-2010. The distribution plan for the Combat Stress Control teams was based on previously published guidance on ratios of combat stress personnel to troop end-strength, population at-risk data, and kinetic activity associated with current and future combat operations. The article concludes with outcome data that validates the distribution decisions made through the planning process. Through dissemination of this information, it is hoped that future planners and clinicians can improve the processes involved in providing combat stress and mental health services to forward-deployed troops. C1 [Jones, David E.] Naval Med Ctr Portsmouth, Portsmouth, VA 23708 USA. [Jones, Franca] Naval Med Res Ctr, Silver Spring, MD 20910 USA. [Suttinger, Laura] 467th Med Detachment Combat Stress Control, Madison, WI 53715 USA. [Toler, Ayessa] CNO OPNAV, Med Resources Plans & Policy Div N931, Washington, DC 20350 USA. [Hammond, Patricia] US Army John F Kennedy Special Warfare Ctr & Sch, ATTN AOJK GRP, Ft Bragg, NC 28310 USA. [Medina, Steven] NAS JRB, RC Fleet Hosp 15, Ft Worth, TX 76127 USA. RP Jones, DE (reprint author), Naval Med Ctr Portsmouth, 620 John Paul Jones Circle, Portsmouth, VA 23708 USA. NR 4 TC 1 Z9 1 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD FEB PY 2013 VL 178 IS 2 BP 121 EP 125 DI 10.7205/MILMED-D-12-00163 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA AN7TW UT WOS:000340804900003 PM 23495454 ER PT J AU Rivers, FM Gordon, S Speraw, S Reese, S AF Rivers, Felecia M. Gordon, Sandra Speraw, Susan Reese, Sharon TI US Army Nurses' Reintegration and Homecoming Experiences After Iraq and Afghanistan SO MILITARY MEDICINE LA English DT Article ID MILITARY PERSONNEL; FAMILIES; WARTIME; RISK AB Objective: The aim of this study was to understand U.S. Army nurses' reintegration and homecoming experiences after deployment to Iraq or Afghanistan. Method: Employing existential phenomenology and purposive sampling, 22 U.S. Army active duty nurses were recruited from two military posts and participated in single digitally recorded interviews. Results: Five themes emerged: (1) aspects of command support were articulated as "No One Cares"; (2) fulfilling requirements for attendance at pre/postdeployment briefings were described as merely "Check the Blocks"; (3) readjustments from focusing strictly on duty requirements versus multitasking, such as family responsibilities and daily living, led to the "Stress of Being Home"; (4) nurses stated "They Don't Understand" when referring to anyone without deployment experience (family, friends, other soldiers); and (5) when referencing deployment experiences, nurses emphasized that, "It Just Changes You." Discussion: Nurses in this study felt that the current reintegration process was not meeting their needs for a smoother homecoming; new or improved interventions to assist redeploying nurses with the transition to a noncombat environment would be beneficial. Educational programs to help nursing supervisors provide optimal leadership support through all phases of deployment are needed. C1 [Rivers, Felecia M.] Womack Army Med Ctr, Ft Bragg, NC 28310 USA. [Gordon, Sandra] Carl R Darnall Army Med Ctr, Ft Hood, TX 76544 USA. [Speraw, Susan] Univ Tennessee, Coll Nursing, Knoxville, TN 37996 USA. [Reese, Sharon] Baylor Univ, Sch Social Work, Waco, TX 76798 USA. RP Rivers, FM (reprint author), Womack Army Med Ctr, 2817 Reilly Rd, Ft Bragg, NC 28310 USA. FU TriService Nursing Research Program [HU0001-10-1-TS16 (N10-C03)] FX This study was funded by the TriService Nursing Research Program, Grant Number HU0001-10-1-TS16 (N10-C03). NR 20 TC 4 Z9 4 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD FEB PY 2013 VL 178 IS 2 BP 166 EP 173 DI 10.7205/MILMED-D-12-00279 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA AN7TW UT WOS:000340804900011 PM 23495462 ER PT J AU Recupero, A Mahnke, CB Pinsker, JE AF Recupero, Anthony Mahnke, C. Becket Pinsker, Jordan E. TI Emerging Technology in Diabetes Care: The Real-Time Diabetes Monitoring System SO MILITARY MEDICINE LA English DT Article ID SELF-MANAGEMENT; MELLITUS; OUTCOMES; PROJECT AB The majority of telemedicine interventions for diabetes have failed to show objective improvements in outcomes. We describe the Real-Time Diabetes Monitoring System (RT-DMS), which augments our successful telemedicine system for pediatric patients with type 1 diabetes by allowing automated uploads of glucometer readings. The addition of automatic transfer of glucometer readings enables RT-DMS to improve patient compliance and increases monitoring by physicians. The system is scalable for use by both children and adults with all forms of diabetes and has the potential to significantly improve clinic workflow, allowing RT-DMS to serve as a model for managing chronic disease using telemedicine. C1 [Recupero, Anthony] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. [Mahnke, C. Becket; Pinsker, Jordan E.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. RP Recupero, A (reprint author), Uniformed Serv Univ Hlth Sci, Dept Pediat, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. OI Pinsker, Jordan/0000-0003-4080-9034 FU U.S. Army Public Health Command through the Health Promotion and Prevention Initiatives (HPPI) program FX The authors thank Eludrizza Tabisola-Nuesca, RN, CDE and Debora Chan, PharmD for their assistance in setting up the TAMC RT-DMS. Resource support for this project was provided by the U.S. Army Public Health Command (formerly the U.S. Army Center for Health Promotion and Preventive Medicine) through the Health Promotion and Prevention Initiatives (HPPI) program. NR 15 TC 3 Z9 3 U1 1 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD FEB PY 2013 VL 178 IS 2 BP 218 EP 221 DI 10.7205/MILMED-D-12-00317 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA AN7TW UT WOS:000340804900018 PM 23495469 ER PT J AU Tarney, CM Whitecar, P Sewell, M Grubish, L Hope, E AF Tarney, Christopher M. Whitecar, Paul Sewell, Mark Grubish, Lindsay Hope, Erica TI Rupture of an Unscarred Uterus in a Quadruplet Pregnancy SO OBSTETRICS AND GYNECOLOGY LA English DT Article AB BACKGROUND: Uterine rupture of an unscarred uterus is a rare complication in a quadruplet pregnancy. CASE: A 30-year-old woman, gravida 4 para 0030, with a quadruplet pregnancy and no previous uterine surgeries presented with moderate vaginal bleeding at 32 4/7 weeks of gestation. Fetal testing was reassuring, and the cervix showed no signs of preterm labor. A decision was made to proceed with cesarean delivery because of the amount of vaginal bleeding, with surgical findings of uterine rupture superior to the lower uterine segment. CONCLUSION: High-order gestations may be an independent risk factor for uterine rupture. C1 [Tarney, Christopher M.] Womack Army Med Ctr, Dept Obstet & Gynecol, Ft Bragg, NC 28307 USA. Walter Reed Natl Mil Med Ctr, Dept Obstet & Gynecol, Bethesda, MD USA. RP Tarney, CM (reprint author), Womack Army Med Ctr, Dept Obstet & Gynecol, 2817 Reilly Rd, Ft Bragg, NC 28307 USA. EM christopher.tarney@us.army.mil NR 8 TC 3 Z9 4 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 EI 1873-233X J9 OBSTET GYNECOL JI Obstet. Gynecol. PD FEB PY 2013 VL 121 IS 2 BP 483 EP 485 DI 10.1097/AOG.0b013e31827c603c PN 2 PG 4 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 300IZ UT WOS:000330458900024 PM 23344417 ER PT J AU Razumovsky, A Tigno, T Kouperberg, E Bell, R Severson, MV Hochheimer, SM Marshall, SA Aden, J Oppenheimer, SM Ecker, R Armonda, RA AF Razumovsky, Alexander Tigno, Teodore Kouperberg, Efim Bell, Randy Severson, Meryl V. Hochheimer, Sven M. Marshall, Scott A. Aden, James Oppenheimer, Stephen M. Ecker, Robert Armonda, Rocco A. TI Cerebral Hemodynamic Changes in Patients with Wartime Traumatic Brain Unjury SO STROKE LA English DT Meeting Abstract CT American-Heart-Association/American-Stroke-Association International Stroke Conference / Nursing Symposium CY FEB 06-08, 2013 CL Honolulu, HI SP Amer Heart Assoc, Amer Stroke Assoc DE Cerebrovascular circulation; Blood flow; Vasoconstriction; Doppler ultrasound; Patient care C1 [Razumovsky, Alexander; Kouperberg, Efim; Oppenheimer, Stephen M.] Sentient NeuroCare Serv, Hunt Valley, MD USA. [Tigno, Teodore; Bell, Randy; Hochheimer, Sven M.; Armonda, Rocco A.] Walter Reed Natl Mil Med Cntr, Bethesda, MD USA. [Severson, Meryl V.] Walter Reed Natl Mil, Hunt Valley, MD USA. [Marshall, Scott A.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Aden, James] US Army Inst Surg Res, Houston, TX USA. [Ecker, Robert] Maine Med Cntr, Portland, ME USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0039-2499 EI 1524-4628 J9 STROKE JI Stroke PD FEB PY 2013 VL 44 IS 2 SU S PG 1 WC Clinical Neurology; Peripheral Vascular Disease SC Neurosciences & Neurology; Cardiovascular System & Cardiology GA 301NY UT WOS:000330540200054 ER PT J AU Eikenberry, KW AF Eikenberry, Karl W. TI Reassessing the All-Volunteer Force SO WASHINGTON QUARTERLY LA English DT Article C1 [Eikenberry, Karl W.] Stanford Univ, Stanford, CA 94305 USA. [Eikenberry, Karl W.] USA, Washington, DC USA. RP Eikenberry, KW (reprint author), Stanford Univ, Stanford, CA 94305 USA. NR 40 TC 2 Z9 2 U1 0 U2 2 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0163-660X J9 WASH QUART JI Wash. Q. PD FEB 1 PY 2013 VL 36 IS 1 BP 7 EP 24 DI 10.1080/0163660X.2013.751647 PG 18 WC International Relations; Law SC International Relations; Government & Law GA 055YE UT WOS:000312453100001 ER PT J AU Bednar, AJ Poda, AR Mitrano, DM Kennedy, AJ Gray, EP Ranville, JF Hayes, CA Crocker, FH Steevens, JA AF Bednar, A. J. Poda, A. R. Mitrano, D. M. Kennedy, A. J. Gray, E. P. Ranville, J. F. Hayes, C. A. Crocker, F. H. Steevens, J. A. TI Comparison of on-line detectors for field flow fractionation analysis of nanomaterials SO TALANTA LA English DT Article DE Nanomaterials; Detection; Sizing; Field flow fractionation; ICP-MS; ICP-AES ID PLASMA-MASS-SPECTROMETRY; DYNAMIC LIGHT-SCATTERING; ENGINEERED NANOPARTICLES; SILVER NANOPARTICLES; MEMBRANE FILTRATION; GOLD NANOPARTICLES; NATURAL COLLOIDS; AQUATIC COLLOIDS; SIZE; ENVIRONMENT AB Characterization of nanomaterials must include analysis of both size and chemical composition. Many analytical techniques, such as dynamic light scattering (DLS), are capable of measuring the size of suspended nanometer-sized particles, yet provide no information on the composition of the particle. While field flow fractionation (FFF) is a powerful nanoparticle sizing technique, common detectors used in conjunction with the size separation, including UV, light-scattering, and fluorescence spectroscopy, do not provide the needed particle compositional information. Further, these detectors do not respond directly to the mass concentration of nanoparticles. The present work describes the advantages achieved when interfacing sensitive and elemental specific detectors, such as inductively coupled plasma atomic emission spectroscopy and mass spectrometry, to FFF separation analysis to provide high resolution nanoparticle sizing and compositional analysis at the mu g/L concentration level, a detection at least 10-100-fold lower than DLS or FFF-UV techniques. The full benefits are only achieved by utilization of all detector capabilities, such as dynamic reaction cell (DRC) ICP-MS. Such low-level detection and characterization capability is critical to nanomaterial investigations at biologically and environmentally relevant concentrations. The techniques have been modified and applied to characterization of all four elemental constituents of cadmium selenide-zinc sulfide core-shell quantum dots, and silver nanoparticles with gold seed cores. Additionally, sulfide coatings on silver nanoparticles can be detected as a potential means to determine environmental aging of nanoparticles. Published by Elsevier B.V. C1 [Bednar, A. J.; Poda, A. R.; Kennedy, A. J.; Crocker, F. H.; Steevens, J. A.] USA, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Mitrano, D. M.; Ranville, J. F.] Colorado Sch Mines, Dept Chem & Geochem, Golden, CO 80401 USA. [Gray, E. P.] Colorado Sch Mines, Dept Civil & Environm Engn, Golden, CO 80401 USA. [Hayes, C. A.] Badger Tech Serv, Vicksburg, MS 39180 USA. RP Bednar, AJ (reprint author), USA, Engn Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM anthony.J.Bednar@usace.army.mil RI Poda, Aimee/K-1905-2012; OI ranville, james/0000-0002-4347-4885 NR 55 TC 37 Z9 38 U1 4 U2 99 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0039-9140 J9 TALANTA JI Talanta PD JAN 30 PY 2013 VL 104 BP 140 EP 148 DI 10.1016/j.talanta.2012.11.008 PG 9 WC Chemistry, Analytical SC Chemistry GA 149HZ UT WOS:000319310900022 PM 23597901 ER PT J AU Gordon, SM Franaszczuk, PJ Hairston, WD Vindiola, M McDowell, K AF Gordon, S. M. Franaszczuk, P. J. Hairston, W. D. Vindiola, M. McDowell, K. TI Comparing parametric and nonparametric methods for detecting phase synchronization in EEG SO JOURNAL OF NEUROSCIENCE METHODS LA English DT Article DE Phase synchronization; Autoregressive modeling; EEG ID VOLUME-CONDUCTION; DYNAMICS; MODEL; SEPARATION; ARTIFACTS; COHERENCY; SIGNALS; INDEX; BIAS AB Detecting significant periods of phase synchronization in EEG recordings is a non-trivial task that is made especially difficult when considering the effects of volume conduction and common sources. In addition, EEG signals are often confounded by non-neural signals, such as artifacts arising from muscle activity or external electrical devices. A variety of phase synchronization analysis methods have been developed with each offering a different approach for dealing with these confounds. We investigate the use of a parametric estimation of the time-frequency transform as a means of improving the detection capability for a range of phase analysis methods. We argue that such an approach offers numerous benefits over using standard nonparametric approaches. We then demonstrate the utility of our technique using both simulated and actual EEG data by showing that the derived phase synchronization estimates are more robust to noise and volume conduction effects. (c) 2012 Elsevier B.V. All rights reserved. C1 [Gordon, S. M.] DCS Corp, Alexandria, VA 22310 USA. [Franaszczuk, P. J.; Hairston, W. D.; McDowell, K.] USA, Human Res & Engn Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Vindiola, M.] DRC High Performance Technol Grp, Reston, VA 20190 USA. [Vindiola, M.] Computat & Informat Sci Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Gordon, SM (reprint author), DCS Corp, Alexandria, VA 22310 USA. EM sgordon@dcscorp.com RI Franaszczuk, Piotr/B-6532-2008 OI Franaszczuk, Piotr/0000-0002-5166-4224 FU Army Research Laboratory [W911NF-10-2-0022] FX The authors would like to thank Jean Vettel of the Army Research Laboratory for helpful discussions and directions with respect to the generation and analysis of simulation data. This research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-10-2-0022. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 29 TC 6 Z9 6 U1 0 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-0270 J9 J NEUROSCI METH JI J. Neurosci. Methods PD JAN 30 PY 2013 VL 212 IS 2 BP 247 EP 258 DI 10.1016/j.jneumeth.2012.10.002 PG 12 WC Biochemical Research Methods; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA 104EJ UT WOS:000315974200011 PM 23085564 ER PT J AU Kota, KP Eaton, B Lane, D Ulrich, M Ulrich, R Peyser, BD Robinson, CG Jaissle, JG Pegoraro, G Bavari, S Panchal, RG AF Kota, Krishna P. Eaton, Brett Lane, Douglas Ulrich, Melanie Ulrich, Ricky Peyser, Brian D. Robinson, Camenzind G. Jaissle, James G. Pegoraro, Gianluca Bavari, Sina Panchal, Rekha G. TI Integrating High-Content Imaging and Chemical Genetics to Probe Host Cellular Pathways Critical for Yersinia Pestis Infection SO PLOS ONE LA English DT Article ID NF-KAPPA-B; EPITHELIAL-CELLS; PNEUMONIC PLAGUE; MACROPHAGES; INVASION; MICE; PATHOGENESIS; APOPTOSIS; RNAI; PHENOTHIAZINES AB The molecular machinery that regulates the entry and survival of Yersinia pestis in host macrophages is poorly understood. Here, we report the development of automated high-content imaging assays to quantitate the internalization of virulent Y. pestis CO92 by macrophages and the subsequent activation of host NF-kappa B. Implementation of these assays in a focused chemical screen identified kinase inhibitors that inhibited both of these processes. Rac-2-ethoxy-3 octadecanamido-1-propylphosphocholine (a protein Kinase C inhibitor), wortmannin (a PI3K inhibitor), and parthenolide (an I kappa B kinase inhibitor), inhibited pathogen-induced NF-kappa B activation and reduced bacterial entry and survival within macrophages. Parthenolide inhibited NF-kappa B activation in response to stimulation with Pam3CSK4 (a TLR2 agonist), E. coli LPS (a TLR4 agonist) or Y. pestis infection, while the PI3K and PKC inhibitors were selective only for Y. pestis infection. Together, our results suggest that phagocytosis is the major stimulus for NF-kappa B activation in response to Y. pestis infection, and that Y. pestis entry into macrophages may involve the participation of protein kinases such as PI3K and PKC. More importantly, the automated image-based screening platform described here can be applied to the study of other bacteria in general and, in combination with chemical genetic screening, can be used to identify host cell functions facilitating the identification of novel antibacterial therapeutics. C1 [Eaton, Brett; Ulrich, Melanie; Ulrich, Ricky; Bavari, Sina; Panchal, Rekha G.] USA, Med Res Inst Infect Dis, Dept Target Discovery & Cellular Microbiol, Frederick, MD USA. [Kota, Krishna P.; Pegoraro, Gianluca] Perkin Elmer, Waltham, MA USA. [Lane, Douglas; Peyser, Brian D.] NCI Frederick, SAIC Frederick, Target Struct Based Drug Discovery Grp, Frederick, MD USA. [Robinson, Camenzind G.] USA, Med Res Inst Infect Dis, Div Pathol, Frederick, MD USA. [Jaissle, James G.] USA, Med Res Inst Infect Dis, Diagnost Syst Div, Frederick, MD USA. RP Panchal, RG (reprint author), USA, Med Res Inst Infect Dis, Dept Target Discovery & Cellular Microbiol, Frederick, MD USA. EM rekha.panchal@amedd.army.mil OI Pegoraro, Gianluca/0000-0003-2843-9464; Peyser, Brian/0000-0002-3455-5181 FU Department of Defense Chemical Biological Defense Program through the Defense Threat Reduction Agency (DTRA) [JSTO-CBD 2.10019_09_RD_B]; National Cancer Institute, National Institutes of Health [N01-CO-12400]; Developmental Therapeutics Program in the Division of Cancer Treatment and Diagnosis of the National Cancer Institute FX This project was funded by the Department of Defense Chemical Biological Defense Program through the Defense Threat Reduction Agency (DTRA) JSTO-CBD 2.10019_09_RD_B (to RGP). This project has been funded in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health, under contract N01-CO-12400. This research was supported, in part, by the Developmental Therapeutics Program in the Division of Cancer Treatment and Diagnosis of the National Cancer Institute. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 51 TC 2 Z9 2 U1 0 U2 8 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JAN 30 PY 2013 VL 8 IS 1 AR e55167 DI 10.1371/journal.pone.0055167 PG 15 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 098QM UT WOS:000315563800125 PM 23383093 ER PT J AU McLaughlin, MP Adduci, LL Becker, JJ Gagne, MR AF McLaughlin, Matthew P. Adduci, Laura L. Becker, Jennifer J. Gagne, Michel R. TI Iridium-Catalyzed Hydrosilylative Reduction of Glucose to Hexane(s) SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Article ID C-GLYCOSYL COMPOUNDS; CARBON-MONOXIDE; BIOMASS; DEOXYGENATION; COMPLEXES; ALCOHOLS; ETHERS; 1,2-PROPANEDIOL; HYDROGENOLYSIS; CONVERSION AB In light of diminishing petroleum feed-stocks, there is significant interest in developing carbohydrate defunctionalization reactions. In this context we have examined the use of iridium pincer catalysts for the hydrosilylative reduction of sugars, and we report herein complete reduction of silyl-protected glucose to a mixture of hexane isomers. C1 [McLaughlin, Matthew P.; Adduci, Laura L.; Gagne, Michel R.] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA. [Becker, Jennifer J.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Gagne, MR (reprint author), Univ N Carolina, Dept Chem, CB 3290, Chapel Hill, NC 27599 USA. EM mgagne@unc.edu FU National Research Council; UNC Institute for the Environment/Progress Energy Foundation; Department of Energy [FG02-05ER15630]; Army Research Office FX M.P.M. thanks the National Research Council for a postdoctoral fellowship, L.L.A. thanks the UNC Institute for the Environment/Progress Energy Foundation for a fellowship, M.R.G. thanks the Department of Energy (FG02-05ER15630), and J.J.B. thanks the Army Research Office for funding. We also thank Dr. Sehoon Park, Dr. Thomas W. Lyons, and Prof. Maurice Brookhart for stimulating conversations and initial experimental assistance, and Dr. Marc ter Horst, for advice in preparing a 13C NMR quantification protocol. NR 45 TC 32 Z9 32 U1 5 U2 119 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD JAN 30 PY 2013 VL 135 IS 4 BP 1225 EP 1227 DI 10.1021/ja3110494 PG 3 WC Chemistry, Multidisciplinary SC Chemistry GA 083VE UT WOS:000314492500014 PM 23305415 ER PT J AU Hurley, M AF Hurley, Margaret TI Computational Approaches to Systems Biology: Multiple Approaches to Clostridium Acetobutylicum SO BIOPHYSICAL JOURNAL LA English DT Meeting Abstract CT 57th Annual Meeting of the Biophysical-Society CY FEB 02-06, 2013 CL Philadelphia, PA SP Biophys Soc C1 [Hurley, Margaret] US Army, Res Lab, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 0006-3495 J9 BIOPHYS J JI Biophys. J. PD JAN 29 PY 2013 VL 104 IS 2 SU 1 BP 496A EP 496A PG 1 WC Biophysics SC Biophysics GA 105MI UT WOS:000316074305017 ER PT J AU Hill, OT Mason, TJ Schwartz, SW Foulis, PR AF Hill, Owen T. Mason, Thomas J. Schwartz, Skai W. Foulis, Philip R. TI Improving prostate cancer detection in veterans through the development of a clinical decision rule for prostate biopsy SO BMC UROLOGY LA English DT Article ID PREVENTION TRIAL; MODEL; RISK AB Background: We sought to improve prostate cancer (PC) detection through developing a prostate biopsy clinical decision rule (PBCDR), based on an elevated PSA and laboratory biomarkers. This decision rule could be used after initial PC screening, providing the patient and clinician information to consider prior to biopsy. Methods: This case-control study evaluated men from the Tampa, Florida, James A. Haley (JH) Veteran's Administration (VA) (N = 1,378), from January 1, 1998, through April 15, 2005. To assess the PBCDR we did all of the following: 1) Identified biomarkers that are related to PC and have the capability of improving the efficiency of PC screening; 2) Developed statistical models to determine which can best predict the probability of PC; 3) Compared each potential model to PSA alone using Receiver Operator Characteristic (ROC) curves, to evaluate for improved overall effectiveness in PC detection and reduction in (negative) biopsies; and 4) Evaluated dose-response relationships between specified lab biomarkers (surrogates for extra-prostatic disease development) and PC progression. Results: The following biomarkers were related to PC: hemoglobin (HGB) (OR = 1.42 95% CI 1.27, 1.59); red blood cell (RBC) count (OR = 2.52 95% CI 1.67, 3.78); PSA (OR = 1.04 95% CI 1.03, 1.05); and, creatinine (OR = 1.55 95% CI 1.12, 2.15). Comparing all PC stages versus non-cancerous conditions, the ROC curve area under the curve (AUC) enlarged (increasing the probability of correctly classifying PC): PSA (alone) 0.59 (95% CI 0.55, 0.61); PBCDR model 0.68 (95% CI 0.65, 0.71), and the positive predictive value (PPV) increased: PSA 44.7%; PBCDR model 61.8%. Comparing PC (stages II, III, IV) vs. other, the ROC AUC increased: PSA (alone) 0.63 (95% CI 0.58, 0.66); PBCDR model 0.72 (95% CI 0.68, 0.75), and the PPV increased: 20.6% (PSA); PBCDR model 55.3%. Conclusions: These results suggest evaluating certain common biomarkers in conjunction with PSA may improve PC prediction prior to biopsy. Moreover, these biomarkers may be more helpful in detecting clinically relevant PC. Follow-up studies should begin with replicating the study on different U.S. VA patients involving multiple practices. C1 [Hill, Owen T.] USA, Injury Epidemiol Res Sect, Mil Performance Div, Inst Environm Med, Natick, MA 01760 USA. [Mason, Thomas J.] Univ S Florida, Coll Publ Hlth, Dept Environm & Occupat Hlth, Tampa, FL 33612 USA. [Schwartz, Skai W.] Univ S Florida, Coll Publ Hlth, Dept Epidemiol & Biostat, Tampa, FL USA. [Foulis, Philip R.] James A Haley Vet Adm, Dept Pathol & Lab Med, Tampa, FL USA. RP Hill, OT (reprint author), USA, Injury Epidemiol Res Sect, Mil Performance Div, Inst Environm Med, Natick, MA 01760 USA. EM owen.hill@us.army.mil RI Hill, Owen/E-3643-2013 NR 13 TC 2 Z9 2 U1 0 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2490 J9 BMC UROL JI BMC Urol. PD JAN 29 PY 2013 VL 13 AR 6 DI 10.1186/1471-2490-13-6 PG 12 WC Urology & Nephrology SC Urology & Nephrology GA 089QJ UT WOS:000314924800001 PM 23356551 ER PT J AU Sanchez, CJ Mende, K Beckius, ML Akers, KS Romano, DR Wenke, JC Murray, CK AF Sanchez, Carlos J., Jr. Mende, Katrin Beckius, Miriam L. Akers, Kevin S. Romano, Desiree R. Wenke, Joseph C. Murray, Clinton K. TI Biofilm formation by clinical isolates and the implications in chronic infections SO BMC INFECTIOUS DISEASES LA English DT Article DE Biofilm formation; Clinical isolates; Chronic infection; Multidrug-resistant; MRSA ID FIELD GEL-ELECTROPHORESIS; STAPHYLOCOCCUS-AUREUS; BACTERIAL BIOFILMS; ACINETOBACTER-BAUMANNII; CHRONIC WOUNDS; IN-VIVO; MECHANISMS; RESISTANCE; EPIDERMIDIS; PHAGOCYTOSIS AB Background: Biofilm formation is a major virulence factor contributing to the chronicity of infections. To date few studies have evaluated biofilm formation in infecting isolates of patients including both Gram-positive and Gram-negative multidrug-resistant (MDR) species in the context of numerous types of infectious syndromes. Herein, we investigated the biofilm forming capacity in a large collection of single patient infecting isolates and compared the relationship between biofilm formation to various strain characteristics. Methods: The biofilm-forming capacity of 205 randomly sampled clinical isolates from patients, collected from various anatomical sites, admitted for treatment at Brooke Army Medical Center (BAMC) from 2004-2011, including methicillin-resistant/methicillin susceptible Staphylococcus aureus (MRSA/MSSA) (n=23), Acinetobacter baumannii (n=53), Pseudomonas aeruginosa (n=36), Klebsiella pneumoniae (n=54), and Escherichia coli (n=39), were evaluated for biofilm formation using the high-throughput microtiter plate assay and scanning electron microscopy (SEM). Relationships between biofilm formation to clonal type, site of isolate collection, and MDR phenotype were evaluated. Furthermore, in patients with relapsing infections, serial strains were assessed for their ability to form biofilms in vitro. Results: Of the 205 clinical isolates tested, 126 strains (61.4%) were observed to form biofilms in vitro at levels greater than or equal to the Staphylococcus epidermidis, positive biofilm producing strain, with P. aeruginosa and S. aureus having the greatest number of biofilm producing strains. Biofilm formation was significantly associated with specific clonal types, the site of isolate collection, and strains positive for biofilm formation were more frequently observed to be MDR. In patients with relapsing infections, the majority of serial isolates recovered from these individuals were observed to be strong biofilm producers in vitro. Conclusions: This study is the first to evaluate biofilm formation in a large collection of infecting clinical isolates representing diverse types of infections. Our results demonstrate: (1) biofilm formation is a heterogeneous property amongst clinical strains which is associated with certain clonal types, (2) biofilm forming strains are more frequently isolated from non-fluid tissues, in particular bone and soft tissues, (3) MDR pathogens are more often biofilm formers, and (4) strains from patients with persistent infections are positive for biofilm formation. C1 [Sanchez, Carlos J., Jr.; Akers, Kevin S.; Romano, Desiree R.; Wenke, Joseph C.] USA, Dept Extrem Trauma & Regenerat Med, Inst Surg Res, Ft Sam Houston, San Antonio, TX USA. [Mende, Katrin] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Mende, Katrin; Akers, Kevin S.; Murray, Clinton K.] Ft Sam Houston, Dept Med, Infect Dis Serv, San Antonio Mil Med Ctr, San Antonio, TX USA. [Beckius, Miriam L.] Ft Sam Houston, Dept Clin Invest, San Antonio Mil, Med Ctr, San Antonio, TX USA. RP Sanchez, CJ (reprint author), USA, Dept Extrem Trauma & Regenerat Med, Inst Surg Res, Ft Sam Houston, San Antonio, TX USA. EM carlos.j.sanchez3@us.army.mil RI Valle, Ruben/A-7512-2013 FU Combat Casualty Research Program, Medical Research and Materiel Command; Armed Forces Health Surveillance Center including the Global Emerging Infectious System; National Academy of Sciences; USUHS Infectious Disease Clinical Research Program FX This work was supported by intramural funding from the Combat Casualty Research Program, Medical Research and Materiel Command to JCW, and Armed Forces Health Surveillance Center including the Global Emerging Infectious System to CKM. CJS is supported by a Post-doctoral Research Associate Fellowship through the National Academy of Sciences. KM is supported through the USUHS Infectious Disease Clinical Research Program. The authors would like to thank Ms. Barbara Hunter at the University of Texas Health Science Center (UTHSCSA) Institutional Electron Microscopy core facility for her assistance with the preparation and processing of samples for scanning electron microscopy. Disclaimer: The views expressed herein are those of the authors and do not reflect the official policy or position of the Department of the Army, Department of Defense, or the US Government. The authors are employees of the US government. This work was prepared as part of their official duties and, as such, there is no copyright to be transferred. NR 43 TC 46 Z9 54 U1 3 U2 76 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD JAN 29 PY 2013 VL 13 AR 47 DI 10.1186/1471-2334-13-47 PG 12 WC Infectious Diseases SC Infectious Diseases GA 086UZ UT WOS:000314714800001 PM 23356488 ER PT J AU Morris, CJ Wilkins, PR May, CM AF Morris, Christopher J. Wilkins, Paul R. May, Chadd M. TI Streak spectroscopy and velocimetry of electrically exploded Ni/Al laminates SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID FOILS; EXPLOSION; WIRES; COMPOSITES; EMISSION; AIR AB We present an experimental and theoretical study of electrically exploded nickel-aluminum (Ni/Al) laminates, lithographically patterned into bow-tie bridge regions, and encapsulated with parylene. The exothermic nature of Ni/Al reactions is well-known at typical self-heating rates of 10(3)-10(6) K/s, but electrical heating allows the interrogation of phenomena at heating rates which are five to six orders of magnitude higher. The use of time-resolved streak camera emission spectroscopy revealed that Ni/Al laminates heated at these higher rates exhibited brighter emission during the first 150 ns of emission than samples composed of either Al or Ni alone, suggesting an exothermic effect which rapidly started and persisted for at least this length of time. We also measured the transduction of electrical energy into kinetic energy through velocity measurements of encapsulation layers ejected from the bridge region. An empirical model using experimental power curves and one empirical fitting parameter successfully predicted these velocities. This model agreed well with experiments from different Al and Ni samples using the same fitting parameter, but an apparent 1.2 J/mg of additional energy from the mixing of Ni and Al was necessary to accurately predict velocities from Ni/Al laminate samples. This energy quantity corresponded to a reference value for the enthalpy of mixing Ni and Al, and likely contributed to both brighter emission and higher than expected velocities observed. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4776731] C1 [Morris, Christopher J.] USA, Res Lab, Adelphi, MD 20783 USA. [Wilkins, Paul R.; May, Chadd M.] Lawrence Livermore Natl Lab, Livermore, CA 94550 USA. RP Morris, CJ (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM christopher.j.morris58.civ@mail.mil NR 42 TC 2 Z9 3 U1 0 U2 12 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JAN 28 PY 2013 VL 113 IS 4 AR 043304 DI 10.1063/1.4776731 PG 7 WC Physics, Applied SC Physics GA 086XZ UT WOS:000314724500017 ER PT J AU Taillon, JA Yang, JH Ahyi, CA Rozen, J Williams, JR Feldman, LC Zheleva, TS Lelis, AJ Salamanca-Riba, LG AF Taillon, Joshua A. Yang, Joon Hyuk Ahyi, Claude A. Rozen, John Williams, John R. Feldman, Leonard C. Zheleva, Tsvetanka S. Lelis, Aivars J. Salamanca-Riba, Lourdes G. TI Systematic structural and chemical characterization of the transition layer at the interface of NO-annealed 4H-SiC/SiO2 metal-oxide-semiconductor field-effect transistors SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID ELECTRON-ENERGY-LOSS; CORE-LEVEL SHIFTS; SILICON-CARBIDE; NITRIC-OXIDE; SPECTROSCOPY; OXIDATION; POLYTYPE; MOSFETS AB We present a systematic characterization of the transition layer at the 4H-SiC/SiO2 interface as a function of nitric oxide (NO) post-annealing time, using high-resolution transmission electron microscopy for structural characterization and spatially resolved electron energy-loss spectroscopy for chemical analysis. We propose a systematic method for determining transition layer width by measuring the monotonic chemical shift of the Si-L-2,L-3 edge across the interface, and compare its efficacy to traditional measures from the literature, revealing the proposed method to be most reliable. A gradual shift in the Si-L-2,L-3 edge onset energy suggests mixed Si-C/Si-O bonding in the transition layer. We confirm an inverse relationship between NO-anneal time and transition layer width, which correlates with improved channel mobility, enhanced N density at the interface, and decreased interface trap density. No excess C was noted in the interfacial region. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4789924] C1 [Taillon, Joshua A.; Yang, Joon Hyuk; Salamanca-Riba, Lourdes G.] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA. [Ahyi, Claude A.; Williams, John R.] Auburn Univ, Dept Phys, Auburn, AL 36849 USA. [Rozen, John; Feldman, Leonard C.] Vanderbilt Univ, Dept Phys & Astron, Nashville, TN 37235 USA. [Zheleva, Tsvetanka S.; Lelis, Aivars J.] USA, Res Lab, Adelphi, MD 20783 USA. RP Taillon, JA (reprint author), Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA. EM jtaillon@umd.edu; riba@umd.edu RI Salamanca-Riba, Lourdes/B-3785-2009 OI Salamanca-Riba, Lourdes/0000-0001-8155-6403 FU NSF as a MRSEC Shared Experimental Facility; U.S. Army Research Laboratory [W911NF-11-2-0044, W911NF-07-2-0046]; Maryland NanoCenter; NispLab FX This research was performed in part at the NIST Center for Nanoscale Science and Technology. We would like to thank Dr. Joshua Schumacher and Mike Hernandez at NIST for their assistance in FIB TEM specimen preparation. We acknowledge the support of the Maryland NanoCenter and its NispLab. The NispLab is supported in part by the NSF as a MRSEC Shared Experimental Facility. This work was supported by the U.S. Army Research Laboratory under Contracts W911NF-11-2-0044 and W911NF-07-2-0046. NR 27 TC 10 Z9 11 U1 5 U2 71 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JAN 28 PY 2013 VL 113 IS 4 AR 044517 DI 10.1063/1.4789924 PG 6 WC Physics, Applied SC Physics GA 086XZ UT WOS:000314724500135 ER PT J AU Strawhecker, KE Hsieh, AJ Chantawansri, TL Kalcioglu, ZI Van Vliet, KJ AF Strawhecker, Kenneth E. Hsieh, Alex J. Chantawansri, Tanya L. Kalcioglu, Z. Ilke Van Vliet, Krystyn J. TI Influence of microstructure on micro-/nano-mechanical measurements of select model transparent poly(urethane urea) elastomers SO POLYMER LA English DT Article DE Poly(urethane urea); AFM; Morphology ID STRESS-STRAIN BEHAVIOR; STRUCTURE-PROPERTY RELATIONSHIPS; SEGMENTED POLYURETHANES; POLY(PROPYLENE GLYCOL); ENERGY-DISSIPATION; MOLECULAR-WEIGHT; SOFT SEGMENTS; MONOL CONTENT; DEFORMATION; COPOLYMERS AB Morphology of 4,4'-dicyclohexylmethane diisocyanate poly(tetramethylene oxide) (PTMO)-diethyl toluenediamine based poly(urethane urea) (PUU) elastomers is investigated by atomic force microscopy (AFM) and compared with elastic modulus data measured from AFM-enabled indentation, dynamic nanoindentation (nanoDMA), and dynamic mechanical analysis (DMA). These measurements highlight the effect of altering the molecular weight (M-w) of PTMO, which is used as a soft segment (SS), on the microstructure. In particular, at SS M-w 2000 g/mol, a strong microphase-separated morphology is observed, whereas a phase-mixed dominated microstructure is noted in PUU with SS M-w of 1000 and 650 g/mol. These observations are also consistent with DMA tan 5 results. Furthermore, instrumented impact indentation is also utilized for elucidation of dynamic damping characteristics in these PUUs. Published by Elsevier Ltd. C1 [Strawhecker, Kenneth E.; Hsieh, Alex J.; Chantawansri, Tanya L.] USA, Res Lab, RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA. [Kalcioglu, Z. Ilke; Van Vliet, Krystyn J.] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA. RP Strawhecker, KE (reprint author), USA, Res Lab, RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA. EM kenneth.e.strawhecker.civ@mail.mil RI Chantawansri, Tanya/N-3601-2013 FU ARL Director's Research Initiative program; U.S. Army through the Institute for Soldier Nanotechnologies [W911NF-07-D-0004]; Army FX KES gratefully acknowledges helpful discussions with Quinn McAllister at the University of Delaware and with Chanmin Su, John Thornton, and Bede Pittenger at Bruker-Nano. ICES acknowledges Dr. Aaron C. Jackson for microtoming. AJH and TLC also acknowledge funding support from the ARL Director's Research Initiative program. AJH, ZIK and KJVV also acknowledge collaboration opportunity through funding support by the U.S. Army through the Institute for Soldier Nanotechnologies, under Contract W911NF-07-D-0004. AJH also thank Dr. Norm Rice of Triton Systems, Inc. (Chelmsford, MA) for providing PUU materials, through an ISN 6.2 project funded by the Army. NR 42 TC 21 Z9 21 U1 5 U2 50 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 J9 POLYMER JI Polymer PD JAN 24 PY 2013 VL 54 IS 2 BP 901 EP 908 DI 10.1016/j.polymer.2012.12.018 PG 8 WC Polymer Science SC Polymer Science GA 078FV UT WOS:000314085000051 ER PT J AU Liao, HX Bonsignori, M Alam, SM McLellan, JS Tomaras, GD Moody, MA Kozink, DM Hwang, KK Chen, X Tsao, CY Liu, PH Lu, XZ Parks, RJ Montefiori, DC Ferrari, G Pollara, J Rao, M Peachman, KK Santra, S Letvin, NL Karasavvas, N Yang, ZY Dai, KF Pancera, M Gorman, J Wiehe, K Nicely, NI Rerks-Ngarm, S Nitayaphan, S Kaewkungwal, J Pitisuttithum, P Tartaglia, J Sinangil, F Kim, JH Michael, NL Kepler, TB Kwong, PD Mascola, JR Nabel, GJ Pinter, A Zolla-Pazner, S Haynes, BF AF Liao, Hua-Xin Bonsignori, Mattia Alam, S. Munir McLellan, Jason S. Tomaras, Georgia D. Moody, M. Anthony Kozink, Daniel M. Hwang, Kwan-Ki Chen, Xi Tsao, Chun-Yen Liu, Pinghuang Lu, Xiaozhi Parks, Robert J. Montefiori, David C. Ferrari, Guido Pollara, Justin Rao, Mangala Peachman, Kristina K. Santra, Sampa Letvin, Norman L. Karasavvas, Nicos Yang, Zhi-Yong Dai, Kaifan Pancera, Marie Gorman, Jason Wiehe, Kevin Nicely, Nathan I. Rerks-Ngarm, Supachai Nitayaphan, Sorachai Kaewkungwal, Jaranit Pitisuttithum, Punnee Tartaglia, James Sinangil, Faruk Kim, Jerome H. Michael, Nelson L. Kepler, Thomas B. Kwong, Peter D. Mascola, John R. Nabel, Gary J. Pinter, Abraham Zolla-Pazner, Susan Haynes, Barton F. TI Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2 SO IMMUNITY LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; NEUTRALIZING ANTIBODIES; MONOCLONAL-ANTIBODIES; EFFICACY TRIAL; V1/V2 DOMAIN; GP120; INFECTION; EPITOPES; GP41; REACTIVITY AB The RV144 HIV-1 trial of the canary pox vector (ALVAC-HIV) plus the gp120 AIDSVAX B/E vaccine demonstrated an estimated efficacy of 31%, which correlated directly with antibodies to HIV-1 envelope variable regions 1 and 2 (V1-V2). Genetic analysis of trial viruses revealed increased vaccine efficacy against viruses matching the vaccine strain at V2 residue 169. Here, we isolated four V2 monoclonal antibodies from RV144 vaccinees that recognize residue 169, neutralize laboratory-adapted HIV-1, and mediate killing of field-isolate HIV-1-infected CD4(+) T cells. Crystal structures of two of the V2 antibodies demonstrated that residue 169 can exist within divergent helical and loop conformations, which contrasted dramatically with the 13 strand conformation previously observed with a broadly neutralizing antibody PG9. Thus, RV144 vaccine-induced immune pressure appears to target a region that may be both sequence variable and structurally polymorphic. Variation may signal sites of HIV-1 envelope vulnerability, providing vaccine designers with new options. C1 [Liao, Hua-Xin; Bonsignori, Mattia; Alam, S. Munir; Tomaras, Georgia D.; Moody, M. Anthony; Kozink, Daniel M.; Hwang, Kwan-Ki; Chen, Xi; Tsao, Chun-Yen; Liu, Pinghuang; Lu, Xiaozhi; Parks, Robert J.; Montefiori, David C.; Ferrari, Guido; Pollara, Justin; Wiehe, Kevin; Nicely, Nathan I.; Haynes, Barton F.] Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC 27710 USA. [McLellan, Jason S.; Yang, Zhi-Yong; Dai, Kaifan; Pancera, Marie; Gorman, Jason; Kwong, Peter D.; Mascola, John R.; Nabel, Gary J.] NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA. [Rao, Mangala; Peachman, Kristina K.; Kim, Jerome H.; Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Santra, Sampa; Letvin, Norman L.] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. [Karasavvas, Nicos; Nitayaphan, Sorachai] Armed Forces Res Inst Med Sci, US Army Med Component, Dept Retrovirol, Bangkok 10400, Thailand. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi 11000, Thailand. [Kaewkungwal, Jaranit] Mahidol Univ, Fac Trop Med, Ctr Excellence Biomed & Publ Hlth Informat BIOPHI, Bangkok 10400, Thailand. [Tartaglia, James] Sanofi Pasteur, Swiftwater, PA 18370 USA. [Sinangil, Faruk] Global Solut Infect Dis, San Francisco, CA 94080 USA. [Kepler, Thomas B.] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA. [Pinter, Abraham] Univ Med & Dent New Jersey, New Jersey Med Sch, Publ Hlth Res Inst Ctr, Newark, NJ 07103 USA. [Zolla-Pazner, Susan] Vet Affairs New York Harbor Healthcare Syst, New York, NY 10010 USA. [Zolla-Pazner, Susan] NYU, Sch Med, Dept Pathol, New York, NY 10016 USA. RP Liao, HX (reprint author), Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC 27710 USA. EM hliao@duke.edu; hayne002@mc.duke.edu RI Ferrari, Guido/A-6088-2015; Tomaras, Georgia/J-5041-2016; OI Kepler, Thomas/0000-0002-1383-6865; Moody, Tony/0000-0002-3890-5855 FU Bill & Melinda Gates Foundation; NIH/NIAID [AI067854, AI100645]; Department of Veterans Affairs [Y1-AI-2642-12]; U.S. Army Medical Research and Material Command (USAMRMC) [Y1-AI-2642-12]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DOD) [W81XWH-07-2-0067]; NIH; NIH grants [S10RR019145, UC6 AI058607, AI64518, P30 AI051445] FX This study was supported by Collaboration for AIDS Vaccine Discovery grants from Bill & Melinda Gates Foundation, by grants from NIH/NIAID (AI067854, the Center for HIV/AIDS Vaccine Immunology, and AI100645, the Center for HIV/AIDS Vaccine Immunology-Immunogen Discovery), by research funds from the Department of Veterans Affairs, by an Interagency Agreement Y1-AI-2642-12 between U.S. Army Medical Research and Material Command (USAMRMC), by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. and the U.S. Department of Defense (DOD), and by intramural NIH support for the NIAID Vaccine Research Center. The authors thank A. Foulger, H. Chen, M. Cooper, S. Crawford, J. Holland, R. De, R. Scearce, L. Jeffries, Jr., A. Hogan, J. Pritchett, D. Pause, E. Solomon, L Sutherland, J. Blinn, and K. Lloyd for expert technical assistance in antibody and HIV-1 Env protein production; D. Marshall and J. Whitesides for expert technical assistance in flow cytometry; and K. Soderberg, J. Kircherr, and C. Andrews for project management. Flow cytometry supported by NIH grants S10RR019145, UC6 AI058607, AI64518, and P30 AI051445. The opinions herein are those of the authors and should not be construed as official or representing the views of the U.S. Department of Health and Human Services, National Institute for Allergy and Infectious Diseases, the Department of Defense, the Department of the Army, or the Department of Veteran Affairs. Materials from the RV144 clinical trial were provided by the Ministry of Public Health, Thailand, the Thai AIDS Vaccine Evaluation Group, and the USMHRP through the Henry M. Jackson Foundation for the Advancement of Military Medicine. H.-X.L., M.B., S.M.A., J.H.K., N.L.M., T.B.K., S.Z.-P., and B.F.H. have filed partent applications on the RV144 V2 mAbs and related antigens used in this study. NR 45 TC 160 Z9 161 U1 4 U2 46 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 1074-7613 J9 IMMUNITY JI Immunity PD JAN 24 PY 2013 VL 38 IS 1 BP 176 EP 186 DI 10.1016/j.immuni.2012.11.011 PG 11 WC Immunology SC Immunology GA 079TQ UT WOS:000314195500019 PM 23313589 ER PT J AU Otsyula, N Angov, E Bergmann-Leitner, E Koech, M Khan, F Bennett, J Otieno, L Cummings, J Andagalu, B Tosh, D Waitumbi, J Richie, N Shi, M Miller, L Otieno, W Otieno, GA Ware, L House, B Godeaux, O Dubois, MC Ogutu, B Ballou, WR Soisson, L Diggs, C Cohen, J Polhemus, M Heppner, DG Ockenhouse, CF Spring, MD AF Otsyula, Nekoye Angov, Evelina Bergmann-Leitner, Elke Koech, Margaret Khan, Farhat Bennett, Jason Otieno, Lucas Cummings, James Andagalu, Ben Tosh, Donna Waitumbi, John Richie, Nancy Shi, Meng Miller, Lori Otieno, Walter Otieno, Godfrey Allan Ware, Lisa House, Brent Godeaux, Olivier Dubois, Marie-Claude Ogutu, Bernhards Ballou, W. Ripley Soisson, Lorraine Diggs, Carter Cohen, Joe Polhemus, Mark Heppner, D. Gray, Jr. Ockenhouse, Christian F. Spring, Michele D. TI Results from tandem Phase 1 studies evaluating the safety, reactogenicity and immunogenicity of the vaccine candidate antigen Plasmodium falciparum FVO merozoite surface protein-1 (MSP1(42)) administered intramuscularly with adjuvant system AS01 SO MALARIA JOURNAL LA English DT Article DE Malaria; Vaccine; Merozoite surface protein-1; Plasmodium ID PROTECTS AOTUS MONKEYS; MALARIA-NAIVE ADULTS; BLOOD-STAGE VACCINE; C-TERMINAL FRAGMENT; INHIBITORY ANTIBODIES; TRIAL; CHALLENGE; GROWTH; RTS,S/AS02A; PARASITES AB Background: The development of an asexual blood stage vaccine against Plasmodium falciparum malaria based on the major merozoite surface protein-1 (MSP1) antigen is founded on the protective efficacy observed in preclinical studies and induction of invasion and growth inhibitory antibody responses. The 42 kDa C-terminus of MSP1 has been developed as the recombinant protein vaccine antigen, and the 3D7 allotype, formulated with the Adjuvant System AS02A, has been evaluated extensively in human clinical trials. In preclinical rabbit studies, the FVO allele of MSP1(42) has been shown to have improved immunogenicity over the 3D7 allele, in terms of antibody titres as well as growth inhibitory activity of antibodies against both the heterologous 3D7 and homologous FVO parasites. Methods: Two Phase 1 clinical studies were conducted to examine the safety, reactogenicity and immunogenicity of the FVO allele of MSP1(42) in the adjuvant system AS01 administered intramuscularly at 0-, 1-, and 2-months: one in the USA and, after evaluation of safety data results, one in Western Kenya. The US study was an open-label, dose escalation study of 10 and 50 mu g doses of MSP1(42) in 26 adults, while the Kenya study, evaluating 30 volunteers, was a double-blind, randomized study of only the 50 mu g dose with a rabies vaccine comparator. Results: In these studies it was demonstrated that this vaccine formulation has an acceptable safety profile and is immunogenic in malaria-naive and malaria-experienced populations. High titres of anti-MSP1 antibodies were induced in both study populations, although there was a limited number of volunteers whose serum demonstrated significant inhibition of blood-stage parasites as measured by growth inhibition assay. In the US volunteers, the antibodies generated exhibited better cross-reactivity to heterologous MSP1 alleles than a MSP1-based vaccine (3D7 allele) previously tested at both study sites. Conclusions: Given that the primary effector mechanism for blood stage vaccine targets is humoral, the antibody responses demonstrated to this vaccine candidate, both quantitative (total antibody titres) and qualitative (functional antibodies inhibiting parasite growth) warrant further consideration of its application in endemic settings. C1 [Otsyula, Nekoye; Koech, Margaret; Otieno, Lucas; Andagalu, Ben; Waitumbi, John; Otieno, Walter; Otieno, Godfrey Allan; Ogutu, Bernhards] Kenya Govt Med Res Ctr, Walter Reed Project, Kisumu, Kenya. [Angov, Evelina; Bergmann-Leitner, Elke; Khan, Farhat; Bennett, Jason; Cummings, James; Tosh, Donna; Richie, Nancy; Shi, Meng; Miller, Lori; Ware, Lisa; House, Brent; Polhemus, Mark; Heppner, D. Gray, Jr.; Ockenhouse, Christian F.; Spring, Michele D.] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD USA. [Godeaux, Olivier; Dubois, Marie-Claude; Ballou, W. Ripley; Cohen, Joe] GlaxoSmithKline Biol, Rixensart, Belgium. [Soisson, Lorraine; Diggs, Carter] US Agcy Int Dev, Washington, DC 20523 USA. RP Ockenhouse, CF (reprint author), Walter Reed Army Inst Res, Malaria Vaccine Branch, 2460 Linden Lane,Bldg 503, Silver Spring, MD USA. EM christian.f.ockenhouse@us.army.mil RI Bennett, Jason/B-3547-2011; Bergmann-Leitner, Elke/B-3548-2011 OI Bergmann-Leitner, Elke/0000-0002-8571-8956 FU Office of the Surgeon General, US Army; US Agency for International Development (USAID); GlaxoSmithKline Biologicals (GSK); US Army Medical and Materiel Research Command (USAMRMC) FX MCD, OG, JC and WRB are employees of GlaxoSmithKline Biologicals s.a. (GSK). They own shares and options to shares in GSK. In addition JC and WRB are listed as inventors of patented malaria vaccines, but do not hold a patent for a malaria vaccine. Specifically EA and JC are listed as inventors on patent for this MSP142FVO antigen. The Study Sponsor was the Office of the Surgeon General, US Army. This study was funded by the US Agency for International Development (USAID), with partial support from GlaxoSmithKline Biologicals (GSK) and the US Army Medical and Materiel Research Command (USAMRMC). There are no other competing interests. NR 39 TC 13 Z9 13 U1 0 U2 9 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD JAN 23 PY 2013 VL 12 AR 29 DI 10.1186/1475-2875-12-29 PG 13 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 118YC UT WOS:000317062200001 PM 23342996 ER PT J AU Chen, L Li, YH Fu, YB Peng, J Mo, MH Stamatakos, M Teal, CB Brem, RF Stojadinovic, A Grinkemeyer, M McCaffrey, TA Man, YG Fu, SW AF Chen, Liang Li, Youhuai Fu, Yebo Peng, Jin Mo, Meng-Hsuan Stamatakos, Michael Teal, Christine B. Brem, Rachel F. Stojadinovic, Alexander Grinkemeyer, Michael McCaffrey, Timothy A. Man, Yan-Gao Fu, Sidney W. TI Role of Deregulated microRNAs in Breast Cancer Progression Using FFPE Tissue SO PLOS ONE LA English DT Article ID EPITHELIAL-MESENCHYMAL TRANSITION; MYOEPITHELIAL CELL LAYER; CONSERVED RNA SEQUENCE; GENE-EXPRESSION; TUMOR INVASION; MIR-200 FAMILY; REPRESSORS ZEB1; METASTASIS; TARGETS; SAMPLES AB MicroRNAs (miRNAs) contribute to cancer initiation and progression by silencing the expression of their target genes, causing either mRNA molecule degradation or translational inhibition. Intraductal epithelial proliferations of the breast are histologically and clinically classified into normal, atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC). To better understand the progression of ductal breast cancer development, we attempt to identify deregulated miRNAs in this process using Formalin-Fixed, Paraffin-Embedded (FFPE) tissues from breast cancer patients. Following tissue microdissection, we obtained 8 normal, 4 ADH, 6 DCIS and 7 IDC samples, which were subject to RNA isolation and miRNA expression profiling analysis. We found that miR-21, miR-200b/c, miR-141, and miR-183 were consistently up-regulated in ADH, DCIS and IDC compared to normal, while miR-557 was uniquely down-regulated in DCIS. Interestingly, the most significant miRNA deregulations occurred during the transition from normal to ADH. However, the data did not reveal a step-wise miRNA alteration among discrete steps along tumor progression, which is in accordance with previous reports of mRNA profiling of different stages of breast cancer. Furthermore, the expression of MSH2 and SMAD7, two important molecules involving TGF-beta pathway, was restored following miR-21 knockdown in both MCF-7 and Hs578T breast cancer cells. In this study, we have not only identified a number of potential candidate miRNAs for breast cancer, but also found that deregulation of miRNA expression during breast tumorigenesis might be an early event since it occurred significantly during normal to ADH transition. Consequently, we have demonstrated the feasibility of miRNA expression profiling analysis using archived FFPE tissues, typically with rich clinical information, as a means of miRNA biomarker discovery. C1 [Chen, Liang; Fu, Yebo; Peng, Jin; Mo, Meng-Hsuan; McCaffrey, Timothy A.; Fu, Sidney W.] George Washington Univ, Sch Med & Hlth Sci, Dept Microbiol Immunol & Trop Med, Div Genom Med,Dept Med, Washington, DC 20052 USA. [Li, Youhuai] Baoji Cent Hosp, Dept Surg, Breast Canc Div, Baoji, Shaanxi, Peoples R China. [Stamatakos, Michael] George Washington Univ, Sch Med & Hlth Sci, Dept Pathol, Washington, DC 20052 USA. [Teal, Christine B.] George Washington Univ, Sch Med & Hlth Sci, Dept Surg, Washington, DC 20052 USA. [Brem, Rachel F.] George Washington Univ, Sch Med & Hlth Sci, Dept Radiol, Washington, DC 20052 USA. [Stojadinovic, Alexander; Grinkemeyer, Michael] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Man, Yan-Gao] Henry Jackson Fdn, Diagnost & Translat Res Ctr, Gaithersburg, MD USA. RP Fu, SW (reprint author), George Washington Univ, Sch Med & Hlth Sci, Dept Microbiol Immunol & Trop Med, Div Genom Med,Dept Med, Washington, DC 20052 USA. EM sfu@gwu.edu OI Chen, Liang/0000-0002-3605-8883 FU Wendy Will Case Foundation; Hao Foundation; NCI/NIH [R21CA159103] FX This work was supported by the Wendy Will Case Foundation, the Hao Foundation and the NCI/NIH awards (R21CA159103) to SWF. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 47 TC 41 Z9 43 U1 1 U2 9 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JAN 23 PY 2013 VL 8 IS 1 AR e54213 DI 10.1371/journal.pone.0054213 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 077IQ UT WOS:000314021500041 PM 23372687 ER PT J AU Lambrechts, L Quillery, E Noel, V Richardson, JH Jarman, RG Scott, TW Chevillon, C AF Lambrechts, Louis Quillery, Elsa Noel, Valerie Richardson, Jason H. Jarman, Richard G. Scott, Thomas W. Chevillon, Christine TI Specificity of resistance to dengue virus isolates is associated with genotypes of the mosquito antiviral gene Dicer-2 SO PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES LA English DT Article DE Aedes aegypti; dengue virus; genotype-by-genotype interaction; Dicer-2; RNAi ID ALLELE FREQUENCY DATA; AEDES-AEGYPTI; DROSOPHILA-MELANOGASTER; RNA INTERFERENCE; POLYMORPHISM DATA; MALARIA PARASITE; COMPUTER-PROGRAM; HOST-DEFENSE; EVOLUTION; IMMUNITY AB In contrast to the prevailing view that invertebrate immunity relies on broad-spectrum recognition and effector mechanisms, intrinsic genetic compatibility between invertebrate hosts and their pathogens is often highly specific in nature. Solving this puzzle requires a better understanding of the molecular basis underlying observed patterns of invertebrate host-pathogen genetic specificity, broadly referred to as genotype-by-genotype interactions. Here, we identify an invertebrate immune gene in which natural polymorphism is associated with isolate-specific resistance to an RNA virus. Dicer-2 (dcr2) encodes a key protein upstream of the RNA interference (RNAi) pathway, a major antiviral component of innate immunity in invertebrates. We surveyed allelic polymorphism at the dcr2 locus in a wild-type outbred population and in three derived isofemale families of the mosquito Aedes aegypti that were experimentally exposed to several, genetically distinct isolates of dengue virus. We found that dcr2 genotype was associated with resistance to dengue virus in a virus isolate-specific manner. By contrast, no such association was found for genotypes at two control loci flanking dcr2, making it likely that dcr2 contains the yet-unidentified causal polymorphism(s). This result supports the idea that host-pathogen compatibility in this system depends, in part, on a genotype-by-genotype interaction between dcr2 and the viral genome, and points to the RNAi pathway as a potentially important determinant of intrinsic insect-virus genetic specificity. C1 [Lambrechts, Louis] Inst Pasteur, CNRS, Insects & Infect Dis URA 3012, F-75724 Paris 15, France. [Quillery, Elsa; Noel, Valerie; Chevillon, Christine] Univ Montpellier 2, Univ Montpellier 1, IRD, MIVEGEC Lab,UMR 5290,CNRS, F-34394 Montpellier 5, France. [Quillery, Elsa; Noel, Valerie; Chevillon, Christine] IRD, UR 224, F-34394 Montpellier 5, France. [Richardson, Jason H.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA. [Jarman, Richard G.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA. [Scott, Thomas W.] Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA. RP Lambrechts, L (reprint author), Inst Pasteur, CNRS, Insects & Infect Dis URA 3012, 25 Rue Docteur Roux, F-75724 Paris 15, France. EM louis.lambrechts@pasteur.fr RI Richardson, Jason/A-9441-2011; Lambrechts, Louis/A-2057-2010; Chevillon, Christine/L-4645-2013 OI Lambrechts, Louis/0000-0001-5958-2138; Chevillon, Christine/0000-0002-1262-5839 FU European Commission [MOIF-CT-2006-039855]; French Agence Nationale de la Recherche [ANR-09-RPDOC-007-01]; French governmental agency Centre National de la Recherche Scientifique (CNRS); French governmental agency Institut de Recherche pour le Developpement; CNRS FX The authors thank Apolline Pichon for help with mosquito genotyping and three anonymous reviewers for helpful comments. L. L. was supported by Marie Curie Outgoing International Fellowship MOIF-CT-2006-039855 from the Sixth Framework Programme of the European Commission and ANR-09-RPDOC-007-01 from the French Agence Nationale de la Recherche. C. C. was funded by the French governmental agencies Centre National de la Recherche Scientifique (CNRS) and Institut de Recherche pour le Developpement. This work received partial support from the CNRS programme 'Maladies Infectieuses Emergentes'. The opinions or assertions contained herein are the private views of the authors and are not to be construed as reflecting the official views of the United States Army, Royal Thai Army or the United States Department of Defense. NR 51 TC 26 Z9 27 U1 1 U2 48 PU ROYAL SOC PI LONDON PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND SN 0962-8452 J9 P ROY SOC B-BIOL SCI JI Proc. R. Soc. B-Biol. Sci. PD JAN 22 PY 2013 VL 280 IS 1751 AR 20122437 DI 10.1098/rspb.2012.2437 PG 9 WC Biology; Ecology; Evolutionary Biology SC Life Sciences & Biomedicine - Other Topics; Environmental Sciences & Ecology; Evolutionary Biology GA 049PC UT WOS:000311994600011 PM 23193131 ER PT J AU Milner, JL Abu-Farha, F Bunget, C Kurfess, T Hammond, VH AF Milner, Justin L. Abu-Farha, Fadi Bunget, Cristina Kurfess, Thomas Hammond, Vincent H. TI Grain refinement and mechanical properties of CP-Ti processed by warm accumulative roll bonding SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Accumulative roll bonding; Severe plastic deformation; CP Titanium; Grain refinement; Electron microscopy; Mechanical characterization ID SEVERE PLASTIC-DEFORMATION; ROOM-TEMPERATURE; ARB PROCESS; BIOMEDICAL APPLICATIONS; ALUMINUM-ALLOY; PURE TITANIUM; SHEAR STRAIN; MICROSTRUCTURE; ECAP; SPD AB Accumulative roll bonding (ARB), a severe plastic deformation technique, was used in this study to process commercially pure titanium (CP-Ti) at 450 degrees C. Sheet samples were processed by seven consecutive ARB cycles, with an overall equivalent strain of 5.6. Mechanical characterization and microstructural examination were carried out on the processed material to track their changes and relationships with regard to one another. Electron microscopy, TEM in particular, revealed significant grain refinement in the material, with submicron microstructure achieved even after one cycle of warm processing. Further processing was shown to progressively fragment the highly elongated grains, ultimately producing a predominantly-equiaxed ultrafine grain structure with an average grain size of similar to 100 nm. Tensile strength and microhardness of the material increased with the number of ARB cycles; the strength-grain size relationship followed the Hall-Petch equation. The overall grain refinement and strengthening levels observed here are close to those reported in the literature for ARB processing of CP-Ti at ambient temperatures. This demonstrates the ability of warm ARE can be as effective as cold ARB, while offering several advantages for industrial utilization. (C) 2012 Elsevier B.V. All rights reserved. C1 [Milner, Justin L.; Abu-Farha, Fadi; Bunget, Cristina] Clemson Univ, Dept Automot Engn, Greenville, SC 29607 USA. [Kurfess, Thomas] Georgia Inst Technol, Dept Mech Engn, Atlanta, GA 30332 USA. [Hammond, Vincent H.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Abu-Farha, F (reprint author), Clemson Univ, Dept Automot Engn, Greenville, SC 29607 USA. EM FADI@clemson.edu FU Army Research Laboratory [W911NF-10-1-0413] FX The authors are grateful to RTI International Metals for providing access to the rolling mill using which all the ARB runs reported in this work were performed. The authors are also grateful to JTEKT-Greenville Technology Center for helping with tensile testing, specimen preparation, optical microscopy, and microhardness measurements. All the electron microscopy work was performed at the Advanced Material Research Lab (AMRL) of Clemson University; the efforts of their team are greatly appreciated. This work was supported in part by the Army Research Laboratory under grant number W911NF-10-1-0413. NR 35 TC 23 Z9 24 U1 5 U2 32 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 EI 1873-4936 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD JAN 20 PY 2013 VL 561 BP 109 EP 117 DI 10.1016/j.msea.2012.10.081 PG 9 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 236YP UT WOS:000325835700014 ER PT J AU Lee, JS Grubaugh, ND Kondig, JP Turell, MJ Kim, HC Klein, TA O'Guinn, ML AF Lee, John S. Grubaugh, Nathan D. Kondig, John P. Turell, Michael J. Kim, Heung-Chul Klein, Terry A. O'Guinn, Monica L. TI Isolation and genomic characterization of Chaoyang virus strain ROK144 from Aedes vexans nipponii from the Republic of Korea SO VIROLOGY LA English DT Article DE Arthropod-specific flavivirus; Mosquito flavivirus; Vector surveillance; Arbovirus ID NATURAL MOSQUITO POPULATION; AMAZON BASIN REGION; FUSING AGENT VIRUS; INSECT FLAVIVIRUS; CULEX; TRANSMISSION; PERU AB During June 2003, mosquito surveillance was conducted at a US Army installation and a US Military training site 2 km south of the demilitarized zone, Republic of Korea. Mosquitoes were collected using Mosquito Magnets (TM), sorted to species, and assayed for the presence of arboviruses. From the 3,149 mosquitoes that were sorted into 126 pools, one Aedes vexans nipponii pool (out of 73 pools) tested positive for flavivirus RNA by reverse transcription-PCR. After isolation from C6/36 cell culture supernatant, the viral genome was sequenced and found to be 98.9% related to Chaoyang virus, a potential arthropod-specific flavivirus. This report details the first identification of Chaoyang virus in the Republic of Korea and highlights its relationship to other flaviviruses. (C) 2012 Elsevier Inc. All rights reserved. C1 [Grubaugh, Nathan D.; Turell, Michael J.] USA, Div Virol, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Kondig, John P.] USA, Diagnost Syst Div, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Kim, Heung-Chul] 168th Multifunct Med Battal, Med Detachment 5, Seoul, South Korea. [Klein, Terry A.] 65th Med Brigade USAMEDDAC Korea, Force Hlth Protect & Prevent Med, Seoul, South Korea. [Lee, John S.; O'Guinn, Monica L.] Mil Infect Dis Res Program, Ft Detrick, MD 21702 USA. RP Lee, JS (reprint author), USA, MIDRP, Res & Mat Command, Bldg 722,504 Scott Ave, Frederick, MD 21702 USA. EM john.s.lee@amedd.army.mil RI Valle, Ruben/A-7512-2013 FU United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD; 65th Medical Brigade, Yongsan, Seoul, ROK; Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance and Response System, Silver Spring, MD; [U0176_09_RD] FX This work was supported through the joint partnership between the United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD; 65th Medical Brigade, Yongsan, Seoul, ROK; and the Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance and Response System, Silver Spring, MD, and was funded in part by the Military Infectious Disease Research Program project # U0176_09_RD. The mention of trade names or commercial products does not constitute endorsement or recommendation for use by the Department of the Army or the Department of Defense. The opinions and assertions contained herein are those of the authors and are not to be construed as official or reflecting the views of the Department of the Army or the Department of Defense. NR 24 TC 18 Z9 18 U1 0 U2 9 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD JAN 20 PY 2013 VL 435 IS 2 BP 220 EP 224 DI 10.1016/j.viro1.2012.10.020 PG 5 WC Virology SC Virology GA 069TE UT WOS:000313459200004 PM 23127596 ER PT J AU Knapik, JJ Graham, B Cobbs, J Thompson, D Steelman, R Jones, BH AF Knapik, Joseph J. Graham, Bria Cobbs, Jacketta Thompson, Diane Steelman, Ryan Jones, Bruce H. TI A prospective investigation of injury incidence and injury risk factors among army recruits in military police training SO BMC MUSCULOSKELETAL DISORDERS LA English DT Article DE Age; Smoking; Exercise; Physical activity; Prior injury; Menstrual cycle; Pregnancy ID EXERCISE-RELATED INJURIES; HAMSTRING STRAIN INJURY; SMOKELESS TOBACCO USE; UNITED-STATES-ARMY; CIGARETTE-SMOKING; STRESS-FRACTURES; PHYSICAL-ACTIVITY; YOUNG MEN; MUSCULOSKELETAL INJURIES; REDUCTION EFFECTIVENESS AB Background: United States Army military police (MP) training is a 19-week course designed to introduce new recruits to basic soldiering skills, Army values and lifestyle, and law enforcement skills and knowledge. The present investigation examined injury rates and injury risk factors in MP training. Methods: At the start of training, 1,838 male and 553 female MP recruits were administered a questionnaire containing items on date of birth, height, weight, tobacco use, prior physical activity, injury history, and menstrual history. Injuries during training were obtained from electronic medical records and the training units provided data on student graduation and attrition. Results: Successfully graduating from the course were 94.3% of the men and 83.7% of the women. Experiencing at least one injury during training were 34.2% of the men and 66.7% of the women (risk ratio (women/men) = 1.95, 95% confidence interval = 1.79-2.13). Recruits were at higher injury risk if they reported that they were older, had smoked in the past, or had performed less frequent exercise or sports prior to MP training. Men were at higher injury risk if they reported a prior injury and women were at higher risk if they reported missing at least six menstrual cycles in the last year or had previously been pregnant. Conclusion: The present investigation was the first to identify injury rates and identify specific factors increasing injury risk during MP training. C1 [Knapik, Joseph J.; Graham, Bria; Steelman, Ryan; Jones, Bruce H.] USA, Inst Publ Hlth, Portfolio Epidemiol & Dis Surveillance, ATTN MCHB IP DI, Aberdeen Proving Ground, MD 21010 USA. [Cobbs, Jacketta] Med Univ S Carolina, Dept Obstet & Gynecol, Charleston, SC 29425 USA. [Thompson, Diane] AIDS Resource Ctr Wisconsin, Milwaukee, WI 53203 USA. RP Knapik, JJ (reprint author), USA, Inst Publ Hlth, Portfolio Epidemiol & Dis Surveillance, ATTN MCHB IP DI, 1570 Stark Rd, Aberdeen Proving Ground, MD 21010 USA. EM joseph.knapik@us.army.mil FU appointment to the Knowledge Preservation Program at the U.S. Army Public Health Command (USAPHC) FX We would like to thank individuals who assisted with the organization of this investigation including Ms Martha Collins, LTC Dean Kucera, MSG James Clayton, LTC Glasscock, MAJ Adam Smith, SSG Jamal Williams, Ms Shelley Delamarter, Ms Portia Ellis and Mr Brian Raymond. This research was supported in part by an appointment to the Knowledge Preservation Program at the U.S. Army Public Health Command (USAPHC) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USAPHC. The views, opinions, and/or findings contained in this report are those of the authors and should not be construed as official Department of the Army position, policy, or decision, unless so designated by other official documentation. Approved for public release; distribution is unlimited. NR 105 TC 13 Z9 14 U1 0 U2 15 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2474 J9 BMC MUSCULOSKEL DIS JI BMC Musculoskelet. Disord. PD JAN 17 PY 2013 VL 14 AR 32 DI 10.1186/1471-2474-14-32 PG 11 WC Orthopedics; Rheumatology SC Orthopedics; Rheumatology GA 124QD UT WOS:000317479400001 PM 23327563 ER PT J AU Elizaga, ML Vasan, S Marovich, MA Sato, AH Lawrence, DN Chaitman, BR Frey, SE Keefer, MC AF Elizaga, Marnie L. Vasan, Sandhya Marovich, Mary A. Sato, Alicia H. Lawrence, Dale N. Chaitman, Bernard R. Frey, Sharon E. Keefer, Michael C. CA MVA Cardiac Safety Working Grp TI Prospective Surveillance for Cardiac Adverse Events in Healthy Adults Receiving Modified Vaccinia Ankara Vaccines: A Systematic Review SO PLOS ONE LA English DT Article ID JANUARY-OCTOBER 2003; T-CELL RESPONSES; PHASE-I TRIAL; SMALLPOX VACCINATION; UNITED-STATES; DRYVAX(R) CHALLENGE; CANDIDATE VACCINE; NYVAC-C; VIRUS; SAFETY AB Background: Vaccinia-associated myo/pericarditis was observed during the US smallpox vaccination (DryVax) campaign initiated in 2002. A highly-attenuated vaccinia strain, modified vaccinia Ankara (MVA) has been evaluated in clinical trials as a safer alternative to DryVax and as a vector for recombinant vaccines. Due to the lack of prospectively collected cardiac safety data, the US Food and Drug Administration required cardiac screening and surveillance in all clinical trials of MVA since 2004. Here, we report cardiac safety surveillance from 6 phase I trials of MVA vaccines. Methods: Four clinical research organizations contributed cardiac safety data using common surveillance methods in trials administering MVA or recombinant MVA vaccines to healthy participants. 'Routine cardiac investigations' (ECGs and cardiac enzymes obtained 2 weeks after injections of MVA or MVA-HIV recombinants, or placebo-controls), and 'Symptom-driven cardiac investigations' are reported. The outcome measure is the number of participants who met the CDC-case definition for vaccinia-related myo/pericarditis or who experienced cardiac adverse events from an MVA vaccine. Results: Four hundred twenty-five study participants had post-vaccination safety data analyzed, 382 received at least one MVA-containing vaccine and 43 received placebo; 717 routine ECGs and 930 cardiac troponin assays were performed. Forty-five MVA recipients (12%) had additional cardiac testing performed; 22 for cardiac symptoms, 19 for ECG/laboratory changes, and 4 for cardiac symptoms with an ECG/laboratory change. No participant had evidence of symptomatic or asymptomatic myo/pericarditis meeting the CDC-case definition and judged to be related to an MVA vaccine. Conclusions: Prospective surveillance of MVA recipients for myo/pericarditis did not detect cardiac adverse reactions in 382 study participants. C1 [Elizaga, Marnie L.] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USA. [Vasan, Sandhya] Aaron Diamond AIDS Res Ctr, New York, NY USA. [Marovich, Mary A.] Walter Reed Army Inst Res, US Mil HIV Res Program, Rockville, MD USA. [Sato, Alicia H.] Fred Hutchinson Canc Res Ctr, SCHARP, Seattle, WA 98104 USA. [Lawrence, Dale N.] NIAID, Div Aids, NIH, Bethesda, MD 20892 USA. [Chaitman, Bernard R.] St Louis Univ, Sch Med, Div Cardiol, St Louis, MO USA. [Frey, Sharon E.] St Louis Univ, Sch Med, Clin Res Div Infect Dis Allergy & Immunol, St Louis, MO USA. [Keefer, Michael C.] Univ Rochester, Sch Med & Dent, Rochester, NY 14627 USA. RP Keefer, MC (reprint author), Univ Rochester, Sch Med & Dent, Rochester, NY 14627 USA. EM Michael_Keefer@URMC.Rochester.edu FU National Institutes of Health [N01 AI25464, UM1 AI069511, UM1 AI068614, UM1 AI046747, UM1 AIO68614, UM1 AI068635] FX This work was supported by the National Institutes of Health grant numbers N01 AI25464, UM1 AI069511, UM1 AI068614, UM1 AI046747, UM1 AIO68614, UM1 AI068635. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 39 TC 11 Z9 11 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JAN 17 PY 2013 VL 8 IS 1 AR e54407 DI 10.1371/journal.pone.0054407 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 073JI UT WOS:000313738900066 PM 23349878 ER PT J AU Zolla-Pazner, S deCamp, AC Cardozo, T Karasavvas, N Gottardo, R Williams, C Morris, DE Tomaras, G Rao, M Billings, E Berman, P Shen, XY Andrews, C O'Connell, RJ Ngauy, V Nitayaphan, S de Souza, M Korber, B Koup, R Bailer, RT Mascola, JR Pinter, A Montefiori, D Haynes, BF Robb, ML Rerks-Ngarm, S Michael, NL Gilbert, PB Kim, JH AF Zolla-Pazner, Susan deCamp, Allan C. Cardozo, Timothy Karasavvas, Nicos Gottardo, Raphael Williams, Constance Morris, Daryl E. Tomaras, Georgia Rao, Mangala Billings, Erik Berman, Phillip Shen, Xiaoying Andrews, Charla O'Connell, Robert J. Ngauy, Viseth Nitayaphan, Sorachai de Souza, Mark Korber, Bette Koup, Richard Bailer, Robert T. Mascola, John R. Pinter, Abraham Montefiori, David Haynes, Barton F. Robb, Merlin L. Rerks-Ngarm, Supachai Michael, Nelson L. Gilbert, Peter B. Kim, Jerome H. TI Analysis of V2 Antibody Responses Induced in Vaccinees in the ALVAC/AIDSVAX HIV-1 Vaccine Efficacy Trial SO PLOS ONE LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; QUATERNARY NEUTRALIZING EPITOPE; V1/V2 DOMAIN; HIV-1-INFECTED INDIVIDUALS; MONOCLONAL-ANTIBODIES; CHEMOKINE RECEPTOR; GP120; POTENT; INFECTION; REGIONS AB The RV144 clinical trial of a prime/boost immunizing regimen using recombinant canary pox (ALVAC-HIV) and two gp120 proteins (AIDSVAX B and E) was previously shown to have a 31.2% efficacy rate. Plasma specimens from vaccine and placebo recipients were used in an extensive set of assays to identify correlates of HIV-1 infection risk. Of six primary variables that were studied, only one displayed a significant inverse correlation with risk of infection: the antibody (Ab) response to a fusion protein containing the V1 and V2 regions of gp120 (gp70-V1V2). This finding prompted a thorough examination of the results generated with the complete panel of 13 assays measuring various V2 Abs in the stored plasma used in the initial pilot studies and those used in the subsequent case-control study. The studies revealed that the ALVAC-HIV/AIDSVAX vaccine induced V2-specific Abs that cross-react with multiple HIV-1 subgroups and recognize both conformational and linear epitopes. The conformational epitope was present on gp70-V1V2, while the predominant linear V2 epitope mapped to residues 165-178, immediately N-terminal to the putative alpha 4 beta 7 binding motif in the mid-loop region of V2. Odds ratios (ORs) were calculated to compare the risk of infection with data from 12 V2 assays, and in 11 of these, the ORs were <= 1, reaching statistical significance for two of the variables: Ab responses to gp70-V1V2 and to overlapping V2 linear peptides. It remains to be determined whether anti-V2 Ab responses were directly responsible for the reduced infection rate in RV144 and whether anti-V2 Abs will prove to be important with other candidate HIV vaccines that show efficacy, however, the results support continued dissection of Ab responses to the V2 region which may illuminate mechanisms of protection from HIV-1 infection and may facilitate the development of an effective HIV-1 vaccine. C1 [Zolla-Pazner, Susan] Vet Affairs Med Ctr, Res Serv, New York, NY USA. [Zolla-Pazner, Susan; Cardozo, Timothy; Williams, Constance] NYU, Sch Med, Dept Pathol, New York, NY USA. [Zolla-Pazner, Susan; Cardozo, Timothy; Williams, Constance] NYU, Sch Med, Dept Biochem & Mol Pharmacol, New York, NY USA. [deCamp, Allan C.; Gottardo, Raphael; Morris, Daryl E.; Gilbert, Peter B.] Fred Hutchinson Canc Res Ctr, Stat Ctr HIV AIDS Res & Prevent SCHARP, Vaccine & Infect Dis Div, Seattle, WA 98104 USA. [Karasavvas, Nicos; Ngauy, Viseth; Nitayaphan, Sorachai; de Souza, Mark] USA, Mat Command, Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Tomaras, Georgia; Shen, Xiaoying; Montefiori, David; Haynes, Barton F.] Duke Univ, Sch Med, Human Vaccine Inst, Durham, NC USA. [Rao, Mangala; Billings, Erik; Andrews, Charla; O'Connell, Robert J.; Robb, Merlin L.; Michael, Nelson L.; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Berman, Phillip] Univ Calif Santa Cruz, Dept Biomol Engn, Santa Cruz, CA 95064 USA. [Korber, Bette] Los Alamos Natl Lab, Theoret Biol & Biophys Grp, Los Alamos, NM USA. [Koup, Richard; Bailer, Robert T.; Mascola, John R.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [Pinter, Abraham] Univ Med & Dent New Jersey, Publ Hlth Res Inst, Newark, NJ 07103 USA. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. [Gilbert, Peter B.] Univ Washington, Dept Biostat, Seattle, WA 98195 USA. RP Zolla-Pazner, S (reprint author), Vet Affairs Med Ctr, Res Serv, New York, NY USA. EM zollas01@nyumc.org RI Morris, Daryl/H-2659-2013; Tomaras, Georgia/J-5041-2016; OI Korber, Bette/0000-0002-2026-5757 FU NIH [HL59725, AI084119, U01, UM1AI-068618]; Military HIV Research Program (MHRP); Department of Veterans Affairs; Bill & Melinda Gates Foundation Collaboration for AIDS Vaccine Discovery (CAVD); Interagency Agreement between the U.S. Army Medical Research and Material Command (USAMRMC) and the National Institutes of Allergy and Infectious Diseases [Y1-AI-2642-12]; cooperative agreement between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. and the U.S. Department of Defense (DOD) [W81XWH-07-2-0067]; Center for HIV/AIDS Vaccine Immunology [AI067854] FX This study was supported in part by NIH grants HL59725 (SZP) and AI084119 (TC), by a contract from the Military HIV Research Program (MHRP) to the Fred Hutchinson Cancer Research Center and NYU, by research funds from the Department of Veterans Affairs, the Bill & Melinda Gates Foundation Collaboration for AIDS Vaccine Discovery (CAVD), grants to DCM, RK, BFH and SZP, and by an Interagency Agreement Y1-AI-2642-12 between the U.S. Army Medical Research and Material Command (USAMRMC) and the National Institutes of Allergy and Infectious Diseases. This work was also supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. and the U.S. Department of Defense (DOD), by a U01-grant from the NIH, AI067854 (the Center for HIV/AIDS Vaccine Immunology), and by NIH grant UM1AI-068618 to the HVTN Laboratory Program. The opinions herein are those of the authors and should not be construed as official or representing the views of the U.S. Department of Health and Human Services, National Institute for Allergy and Infectious Diseases, the Department of Defense, the Department of the Army, or the Department of Veterans Affairs. The funders had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript. NR 45 TC 65 Z9 66 U1 2 U2 20 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JAN 17 PY 2013 VL 8 IS 1 AR e53629 DI 10.1371/journal.pone.0053629 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 073JI UT WOS:000313738900015 PM 23349725 ER PT J AU Mancuso, JD Bernardo, J Mazurek, GH AF Mancuso, James D. Bernardo, John Mazurek, Gerald H. TI The Elusive "Gold" Standard for Detecting Mycobacterium tuberculosis Infection SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Editorial Material ID CONVERSION; TESTS C1 [Mancuso, James D.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Bernardo, John] Boston Univ, Sch Med, Ctr Pulm, Boston, MA 02118 USA. [Mazurek, Gerald H.] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA USA. RP Mancuso, JD (reprint author), Walter Reed Army Inst Res, Silver Spring, MD USA. OI Bernardo, John/0000-0002-3922-0559 NR 12 TC 11 Z9 11 U1 0 U2 3 PU AMER THORACIC SOC PI NEW YORK PA 61 BROADWAY, FL 4, NEW YORK, NY 10006 USA SN 1073-449X J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PD JAN 15 PY 2013 VL 187 IS 2 BP 122 EP 124 DI 10.1164/rccm.201211-2033ED PG 3 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 075YY UT WOS:000313924600006 PM 23322793 ER PT J AU Campione, S de Ceglia, D Vincenti, MA Scalora, M Capolino, F AF Campione, Salvatore de Ceglia, Domenico Vincenti, Maria Antonietta Scalora, Michael Capolino, Filippo TI Electric field enhancement in epsilon-near-zero slabs under TM-polarized oblique incidence SO PHYSICAL REVIEW B LA English DT Article ID ARTIFICIAL DIELECTRIC MEDIUM; PLASMONIC MATERIALS; OPTICAL-CONSTANTS; LOW-PERMITTIVITY; BREWSTER ANGLE; COMPLEX-MODES; METAMATERIALS; REFLECTION; RADIATION; ARRAYS AB We investigate local-field enhancement phenomena in subwavelength, epsilon-near-zero (ENZ) slabs that do not exploit Fabry-Perot resonances. In particular, we study the linear response of engineered metamaterial slabs of finite thickness based on plasmonic nanoshells that show an ENZ band in the visible range, and naturally occurring materials (e.g., SiO2) that also display ENZ properties, under oblique, TM-polarized plane-wave incidence. We then introduce active gain material in engineered metamaterial slabs that adds peculiar spectral and angular features to transmission, reflection, and absorption properties, and leads to a further local-field enhancement. These findings are supported by two theoretical studies: First, a simple interface between two semi-infinite media, namely free space and a generic ENZ medium; then, an ENZ slab of finite thickness, with the aim of understanding the system's behavior when varying the ENZ properties as well as the incident angle. For either case we report three distinct physical conditions for which we explain spectral and angular features that might result in strong field enhancement. The gain-assisted metamaterial implementation has the potential of triggering and enhancing low-threshold nonlinear phenomena thanks to the large local fields found at specific frequency and angular bands. DOI: 10.1103/PhysRevB.87.035120 C1 [Campione, Salvatore; Capolino, Filippo] Univ Calif Irvine, Dept Elect Engn & Comp Sci, Irvine, CA 92697 USA. [de Ceglia, Domenico; Vincenti, Maria Antonietta] Aegis Technol Inc, Huntsville, AL 35806 USA. [de Ceglia, Domenico; Vincenti, Maria Antonietta; Scalora, Michael] USA, Charles M Bowden Res Ctr, RDECOM, Huntsville, AL 35898 USA. RP Campione, S (reprint author), Univ Calif Irvine, Dept Elect Engn & Comp Sci, Irvine, CA 92697 USA. EM f.capolino@uci.edu RI Campione, Salvatore/A-2349-2015 OI Campione, Salvatore/0000-0003-4655-5485 NR 38 TC 28 Z9 28 U1 2 U2 57 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9950 EI 2469-9969 J9 PHYS REV B JI Phys. Rev. B PD JAN 15 PY 2013 VL 87 IS 3 AR 035120 DI 10.1103/PhysRevB.87.035120 PG 11 WC Physics, Condensed Matter SC Physics GA 070XJ UT WOS:000313547100001 ER PT J AU Mountney, A Leung, LY Pedersen, R Shear, D Torte, F AF Mountney, Andrea Leung, Lai Yee Pedersen, Rebecca Shear, Deborah Torte, Frank TI Longitudinal assessment of gait abnormalities following penetrating ballistic-like brain injury in rats SO JOURNAL OF NEUROSCIENCE METHODS LA English DT Article DE TBI; CatWalk; Gait analysis; PBBI; Longitudinal profile ID MODEL; STROKE; MOTOR; IMPAIRMENT; LOCOMOTION; MOVEMENT; RECOVERY; DEFICITS; NUCLEUS; LESIONS AB Traumatic brain injury (TBI) results in enduring motor and cognitive dysfunction. Although gait disturbances have been documented among TBI patients, few studies have profiled gait abnormalities in animal models of TBI. We sought to obtain a comprehensive longitudinal analysis of gait function following severe penetrating ballistic-like brain injury (PBBI) in rats. Rats were subjected to either unilateral frontal PBBI, probe insertion alone, or sham surgery. Sensorimotor performance was assessed using the CatWalk automated gait analysis system. Baseline measurements were taken 3 days prior to injury and detailed analysis of gait was performed at 1, 3, 7, 14, and 28 days post-injury. Both PBBI and probe-inserted rats displayed altered static and dynamic gait parameters that were primarily evident during the early (<7 days) post-injury phase and were resolved by 1 month post-injury. PBBI produced more severe deficits compared to probe-alone which were reflected in the number, magnitude, and resolution time of abnormal gait parameters. While altered parameters were detected in all four paws, they were more apparent on the contralateral side. Gait parameters including paw pressure, print area, swing speed, and stride length were significantly decreased whereas stance, swing, and step cycle duration were increased compared to sham. Overall, altered gait patterns detected using the CatWalk system in the PBBI model were injury-severity dependent, resolved at later time points, and appeared similar to those reported in severe TBI patients. These results indicate that the CatWalk may be most useful for neuroprotection studies that focus on the acute/subacute recovery period after TBI. Published by Elsevier B.V. C1 [Mountney, Andrea; Leung, Lai Yee; Pedersen, Rebecca; Shear, Deborah; Torte, Frank] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Nemorestorat Branch, Silver Spring, MD 20910 USA. RP Mountney, A (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Nemorestorat Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Andrea.Mountney@amedd.army.mil RI Leung, Lai Yee/H-8204-2013 FU Army Combat Casualty Care Research Program; National Research Council Research Associateship Award at Walter Reed Army Institute of Research FX The authors are grateful for the technical assistance provided by Weihong Yang. This research was funded by the Army Combat Casualty Care Research Program and performed while the author held a National Research Council Research Associateship Award at Walter Reed Army Institute of Research NR 36 TC 12 Z9 12 U1 0 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-0270 J9 J NEUROSCI METH JI J. Neurosci. Methods PD JAN 15 PY 2013 VL 212 IS 1 BP 1 EP 16 DI 10.1016/j.jneumeth.2012.08.025 PG 16 WC Biochemical Research Methods; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA 068UB UT WOS:000313390600001 PM 22981945 ER PT J AU Singh, RSP Das, U Auschwitz, JM Leed, SE Hickman, MR Dimmock, JR Alcorn, J AF Singh, Ravi S. P. Das, Umashankar Auschwitz, Jennifer M. Leed, Susan E. Hickman, Mark R. Dimmock, Jonathan R. Alcorn, Jane TI From a cytotoxic agent to the discovery of a novel antimalarial agent SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS LA English DT Article DE Antimalarial; 3,5-Bis(benzylidene)-4-piperidones; CACO-2 cells; Drug resistance; Glutathione; Plasmodium falciparum ID MALARIA AB A novel cytotoxin 3,5-bis(4-chlorobenzylidene)-1-[4-{2-(4-morpholinyl)ethoxy}phenyl-carbonyl]-4-piperidone hydrochloride 2 demonstrated potent antimalarial properties with IC50 values of 0.60 and 1.97 mu M against the drug sensitive D6 strain and the C235 drug-resistant strain of Plasmodium falciparum. This compound concentrates in red blood cells, lowers glutathione concentrations in erythrocytes and permeates across CACO-2 cells. These data reveal 2 to be a promising lead compound in the quest for novel antimalarial agents. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Singh, Ravi S. P.; Das, Umashankar; Dimmock, Jonathan R.; Alcorn, Jane] Univ Saskatchewan, Coll Pharm & Nutr, Drug Design & Discovery Res Grp, Saskatoon, SK S7N 5C9, Canada. [Auschwitz, Jennifer M.; Leed, Susan E.; Hickman, Mark R.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Alcorn, J (reprint author), Univ Saskatchewan, Coll Pharm & Nutr, Drug Design & Discovery Res Grp, Saskatoon, SK S7N 5C9, Canada. EM jane.alcorn@usask.ca RI Singh, Ravi Shankar /L-9408-2014 OI Singh, Ravi Shankar /0000-0001-6298-8219 FU Canadian Institutes of Health Research [ROP-53171]; Forge Ahead Fund from the Industry Liaison Office at the University of Saskatchewan; College of Graduate Studies and Research, University of Saskatchewan FX The Canadian Institutes of Health Research (ROP-53171) and the Forge Ahead Fund from the Industry Liaison Office at the University of Saskatchewan funded this project. Dr. Wolfgang Koester and Dr. Taseen Desin, VIDO, University of Saskatchewan are thanked for their support in establishing the CACO-2 cells. We thank Jatinder Kaur Mukker and Deborah Michel for their assistance. The Walter Reed Army Institute of Research kindly undertook the evaluation of 2 against the D6 and C235 strains of Plasmodium falciparum. The opinions in this publication of authors at the Walter Reed Army Institute of Research are solely those of the authors and do not reflect the views of the US Department of Defense. R.S.P. Singh was supported by a Dean's scholarship from the College of Graduate Studies and Research, University of Saskatchewan. NR 18 TC 1 Z9 1 U1 0 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0960-894X J9 BIOORG MED CHEM LETT JI Bioorg. Med. Chem. Lett. PD JAN 15 PY 2013 VL 23 IS 2 BP 584 EP 587 DI 10.1016/j.bmcl.2012.10.126 PG 4 WC Chemistry, Medicinal; Chemistry, Organic SC Pharmacology & Pharmacy; Chemistry GA 062YD UT WOS:000312959600041 PM 23228469 ER PT J AU Kragh-Buetow, KC Weng, X Readinger, ED Wraback, M Mohney, SE AF Kragh-Buetow, K. C. Weng, X. Readinger, E. D. Wraback, M. Mohney, S. E. TI Effect of polarity on Ni/InN interfacial reactions SO APPLIED PHYSICS LETTERS LA English DT Article ID T-METALLE MANGAN; STICKSTOFFLEGIERUNGEN; EISEN AB Ni films on (0001) and (000 (1) over bar) InN exhibited different reaction kinetics upon annealing at 673K. Structural and chemical analysis using grazing incidence X-ray diffraction, transmission electron microscopy, and X-ray energy dispersive spectrometry indicated that an interfacial reaction did not occur between the Ni film and the In-polar (0001) InN layer. However, the N-polar face reacted with Ni to form the Ni3InNx ternary phase with an anti-perovskite structure. The difference in reactivity for Ni on In-face and N-face InN indicates that polarity alters the reaction and may also affect interactions between other metals and group III-nitride semiconductors. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4781768] C1 [Kragh-Buetow, K. C.; Mohney, S. E.] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. [Weng, X.; Mohney, S. E.] Penn State Univ, Mat Res Inst, University Pk, PA 16802 USA. [Readinger, E. D.; Wraback, M.] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Mohney, SE (reprint author), Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. EM sem2@psu.edu RI weng, xiaojun/D-5096-2011 FU 3M Corporation; NASA FX Gratitude is expressed to Jillian Woolridge for assistance with translating literature from German, and Nichole Wonderling for assistance with X-ray diffraction. K. C. Kragh-Buetow appreciates funding from the 3M Corporation and NASA. NR 10 TC 0 Z9 0 U1 0 U2 22 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JAN 14 PY 2013 VL 102 IS 2 AR 021607 DI 10.1063/1.4781768 PG 4 WC Physics, Applied SC Physics GA 072KQ UT WOS:000313670200018 ER PT J AU Chantawansri, TL Sirk, TW Sliozberg, YR AF Chantawansri, Tanya L. Sirk, Timothy W. Sliozberg, Yelena R. TI Entangled triblock copolymer gel: Morphological and mechanical properties SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID DISSIPATIVE PARTICLE DYNAMICS; MOLECULAR-DYNAMICS; SELECTIVE SOLVENT; DIBLOCK COPOLYMERS; BLOCK-COPOLYMER; VISCOELASTIC PROPERTIES; POLYMER NETWORKS; DPD SIMULATION; PHASE-BEHAVIOR; AGGREGATION AB The morphological and mechanical properties of entangled ABA triblock copolymer gels, where solvent were selective to the midblock, were studied as a function of polymer concentration using a novel dissipative particle dynamics model which includes a modified segmental repulsive potential that restricts chain crossing. Morphological properties, such as micelle size, distance between micelles, and the bridge fraction, were calculated as a function of concentration. Although the micelle size was shown to have a strong dependence on concentration, the bridge fraction and distance between micelles were shown to plateau at moderate concentrations. Deformation under uni-axial tension was also performed to extract the cross-link and entanglement contribution to the elastic modulus. Scaling results qualitatively agree with other theoretical predications. [http://dx.doi.org/10.1063/1.4774373] C1 [Chantawansri, Tanya L.; Sirk, Timothy W.; Sliozberg, Yelena R.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Chantawansri, TL (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RI Chantawansri, Tanya/N-3601-2013 FU U.S. Army Research Laboratory Enterprise for Multi-scale Research of Materials FX This work was partially funded by the U.S. Army Research Laboratory Enterprise for Multi-scale Research of Materials. Y.R.S. and T. W. S. were partially supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. Calculations were performed on DOD High Performance Computing site at the AFRL through the Challenge Project C5M. NR 56 TC 10 Z9 10 U1 6 U2 62 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD JAN 14 PY 2013 VL 138 IS 2 AR 024908 DI 10.1063/1.4774373 PG 10 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 072BF UT WOS:000313642500067 PM 23320722 ER PT J AU Bykhovski, A Zhang, WD Jensen, J Woolard, D AF Bykhovski, Alexei Zhang, Weidong Jensen, James Woolard, Dwight TI Analysis of Electronic Structure, Binding, and Vibrations in Biotin-Streptavidin Complexes Based on Density Functional Theory and Molecular Mechanics SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID DYNAMICS; ENERGY; POTENTIALS; PROTEINS; ABSOLUTE AB In this work, the biotin-streptavidin complex was studied with density functional theory (DFT), molecular mechanical methods (MM), and a hybrid DFT/MM approach in order to obtain the theoretical predictions for electronic structures, binding, optical transitions, harmonic vibrations, and absorption spectra. It was demonstrated that biotin solvation in water can reduce the binding strength to streptavidin by more than half. All studied properties, including the biotin binding and the UV absorption of the biotin-streptavidin complex, are predicted to be protonation state depen- dent. The absorption edge of the complex calculated with TDDFT/MM was found to be virtually insensitive to the choice of the MM force field and strongly dependent on the type of embedding of the DFT partition. Both UV and terahertz light absorption spectra are predicted to be sensitive to the presence of biotin in the streptavidin tetramer. C1 [Bykhovski, Alexei; Zhang, Weidong; Woolard, Dwight] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. [Jensen, James] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Woolard, Dwight] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Bykhovski, A (reprint author), N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. EM abykhov@ncsu.edu FU U.S. Army Research Laboratory (ARL); National Research Council (NRC) FX This work was supported by a U.S. Army Research Laboratory (ARL) award and by a National Research Council (NRC) fellowship. NR 27 TC 4 Z9 4 U1 1 U2 35 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD JAN 10 PY 2013 VL 117 IS 1 BP 25 EP 37 DI 10.1021/jp3075833 PG 13 WC Chemistry, Physical SC Chemistry GA 066KV UT WOS:000313220600004 PM 23214720 ER PT J AU Fox, ET Paillard, E Borodin, O Henderson, WA AF Fox, Eric T. Paillard, Elie Borodin, Oleg Henderson, Wesley A. TI Physicochemical Properties of Binary Ionic Liquid-Aprotic Solvent Electrolyte Mixtures SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID NANOSTRUCTURAL ORGANIZATION; ORGANIC-SOLVENTS; PLUS ETHANOL; 313.15 K; VISCOSITY; WATER; CONDUCTIVITY; PERFORMANCE; CHLORIDE; ESTERS AB The properties of mixtures of ionic liquids (ILs) with a variety of different aprotic solvents have been examined in detail. The ILs selected bis(trifluoromethanesulfonyl)imide (TFSI-) salts with N-methyl-N-pentylpyrrolidinium (PY15+), -piperidinium (PI15+), or -morpholinium (MO15+) cations enabled the investigation of how cation structure influences the mixture properties. This study includes the characterization of the thermal phase behavior of the mixtures and volatility of the solvents, density and excess molar volume, and transport properties (viscosity and conductivity). The mixtures with ethylene carbonate form a simple eutectic, whereas those with ethyl butyrate appear to form a new IL-solvent crystalline phase. Significant differences in the viscosity of the mixtures are found for different solvents, especially for the IL-rich concentrations. In contrast, only minor differences are noted for the conductivity with different solvents for the IL-rich concentrations. For the solvent-rich concentrations, however, substantial differences are noted in the conductivity, especially for the mixtures with acetonitrile. C1 [Fox, Eric T.; Paillard, Elie; Henderson, Wesley A.] N Carolina State Univ, Dept Chem & Biomol Engn, ILEET Lab, Raleigh, NC 27695 USA. [Borodin, Oleg] USA, Electrochem Branch, Sensor & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA. RP Henderson, WA (reprint author), N Carolina State Univ, Dept Chem & Biomol Engn, ILEET Lab, Raleigh, NC 27695 USA. EM whender@ncsu.edu RI Borodin, Oleg/B-6855-2012; Paillard, Elie/F-6798-2015 OI Borodin, Oleg/0000-0002-9428-5291; Paillard, Elie/0000-0002-5630-0569 FU U.S. Department of Energy, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering [DE-DC0001912]; U.S. Department of Energy; U.S. Army Research Laboratory [DE-IA01-11EE003413] FX The authors express their gratitude to the U.S. Department of Energy, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering, which fully supported the experimental research under Award DE-DC0001912. The preliminary computational work was partially supported by an Interagency Agreement between the U.S. Department of Energy and the U.S. Army Research Laboratory under DE-IA01-11EE003413 for the Office of Vehicle Technologies Programs including the Batteries for Advanced Transportation Technologies (BATT) Program. NR 37 TC 25 Z9 25 U1 2 U2 72 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD JAN 10 PY 2013 VL 117 IS 1 BP 78 EP 84 DI 10.1021/jp3089403 PG 7 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 066KW UT WOS:000313220700011 ER PT J AU Baril, N Billman, C Maloney, P Nallon, E Tidrow, M Pellegrino, J Bandara, S AF Baril, Neil Billman, Curtis Maloney, Patrick Nallon, Eric Tidrow, Meimei Pellegrino, Joseph Bandara, Sumith TI Optimization of thickness and doping of heterojunction unipolar barrier layer for dark current suppression in long wavelength strain layer superlattice infrared detectors SO APPLIED PHYSICS LETTERS LA English DT Article AB Suppression of generation-recombination dark current and bias stability in long wavelength infrared (LWIR) strained layer superlattice (SLS) detectors, consisting of a lightly doped p-type absorber layer and a wide bandgap hole barrier, are investigated with respect to the wide bandgap barrier layer thickness and doping profile. Dark current IV, photoresponse, and theoretical modeling are used to correlate device performance with the widegap barrier design parameters. Decreased dark current density and increased operating bias were observed as the barrier thickness was increased. This study also identifies key device parameters responsible for optimal performance of heterojunction based SLS LWIR detector. [http://dx.doi.org/10.1063/1.4775376] C1 [Baril, Neil] Corbin Co, Alexandria, VA 22314 USA. [Baril, Neil; Billman, Curtis; Maloney, Patrick; Nallon, Eric; Tidrow, Meimei; Pellegrino, Joseph; Bandara, Sumith] USA, RDECOM, CERDEC, NVESD, Ft Belvoir, VA 22060 USA. RP Bandara, S (reprint author), USA, RDECOM, CERDEC, NVESD, Ft Belvoir, VA 22060 USA. EM info@nvl.army.mil NR 13 TC 6 Z9 6 U1 2 U2 16 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JAN 7 PY 2013 VL 102 IS 1 AR 013509 DI 10.1063/1.4775376 PG 4 WC Physics, Applied SC Physics GA 072CQ UT WOS:000313646500131 ER PT J AU Suchalkin, S Jung, S Tober, R Belkin, MA Belenky, G AF Suchalkin, S. Jung, S. Tober, R. Belkin, M. A. Belenky, G. TI Optically tunable long wavelength infrared quantum cascade laser operated at room temperature SO APPLIED PHYSICS LETTERS LA English DT Article ID WAVE-GUIDES; FREQUENCY AB We demonstrate rapid tuning of the emission frequency of a room-temperature mid-infrared quantum cascade laser by external optical pumping. Emission frequency tuning over 0.3 cm(-1) (10GHz) has been achieved for a lambda = 9 mu m device by optical generation of electron-hole pairs along the entire length of the laser stripe. Measurements indicate that this approach allows for rapid broadband frequency-modulation of mid-infrared quantum cascade lasers at above 300MHz modulation frequencies. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4774267] C1 [Suchalkin, S.; Jung, S.; Belenky, G.] SUNY Stony Brook, Dept Elect & Comp Engn, Stony Brook, NY 11794 USA. [Tober, R.] Univ Texas Austin, Dept Elect & Comp Engn, Austin, TX 78759 USA. [Belkin, M. A.] USA, Res Lab, Adelphi, MD 20873 USA. RP Suchalkin, S (reprint author), SUNY Stony Brook, Dept Elect & Comp Engn, Stony Brook, NY 11794 USA. RI Belkin, Mikhail/E-9041-2013 OI Belkin, Mikhail/0000-0003-3172-9462 FU National Science Foundation [ECCS 1028435, ECCS 1028473] FX We wish to thank Professor B. Laikhtman for stimulating discussions. This work was supported by National Science Foundation Grant Nos. ECCS 1028435 and ECCS 1028473. NR 18 TC 7 Z9 7 U1 0 U2 30 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JAN 7 PY 2013 VL 102 IS 1 AR 011125 DI 10.1063/1.4774267 PG 4 WC Physics, Applied SC Physics GA 072CQ UT WOS:000313646500025 ER PT J AU Vincenti, MA Grande, M Bianco, GV de Ceglia, D Stomeo, T De Vittorio, M Petruzzelli, V Bruno, G D'Orazio, A Scalora, M AF Vincenti, M. A. Grande, M. Bianco, G. V. de Ceglia, D. Stomeo, T. De Vittorio, M. Petruzzelli, V. Bruno, G. D'Orazio, A. Scalora, M. TI Surface-enhanced Raman scattering from finite arrays of gold nano-patches SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID SINGLE-MOLECULE; SERS; NANOPARTICLES AB We experimentally investigate the surface-enhanced Raman scattering (SERS) response of a 2D-periodic array of square gold nano-patches, functionalized by means of a conjugated, rigid thiol. We measure a Raman signal enhancement up to 200 times more intense compared to other plasmon-based nanostructures functionalized with the same molecule, and show that the enhancement is not strictly correlated to the presence of plasmonic resonances. The agreement between experimental and theoretical results reveals the importance of a full-wave analysis based on the inclusion of the actual scattering cross section of the molecule. The proposed numerical approach may serve not only as a tool to predict the enhancement of Raman signal scattered from strongly resonant nanostructure but also as an effective instrument to engineer SERS platforms that target specific molecules. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4772725] C1 [Vincenti, M. A.; de Ceglia, D.] AEgis Technol Inc, Huntsville, AL 35806 USA. [Vincenti, M. A.; de Ceglia, D.; Scalora, M.] USA, Charles M Bowden Res Lab, Huntsville, AL USA. [Grande, M.; Petruzzelli, V.; D'Orazio, A.] Politecn Bari, Dipartimento Elettrotecn & Elettron, I-70125 Bari, Italy. [Bianco, G. V.; Bruno, G.] IMIP CNR, I-70126 Bari, Italy. [Stomeo, T.; De Vittorio, M.] Ist Italiano Technol IIT, Ctr Biomol Nanotechnol, I-73010 Lecce, Italy. [De Vittorio, M.] Univ Salento, Dip Ingn Innovaz, CNR Ist Nanosci, Natl Nanotechnol Lab NNL, I-73010 Lecce, Italy. RP Vincenti, MA (reprint author), AEgis Technol Inc, 410 Jan Davis Dr, Huntsville, AL 35806 USA. EM mvincenti@aegistg.com RI Petruzzelli, Vincenzo/E-5576-2015; Petruzzelli, Vincenzo/H-5188-2012; De Vittorio, Massimo/I-5250-2012; OI Petruzzelli, Vincenzo/0000-0001-6921-9981; Petruzzelli, Vincenzo/0000-0001-6921-9981; De Vittorio, Massimo/0000-0003-1601-6392; BIANCO, GIUSEPPE VALERIO/0000-0002-0986-1531; BRUNO, GIOVANNI/0000-0003-3116-1176 FU National Research Council at the U.S. Army Aviation and Missile Research Development and Engineering Center; U.S. Army International Technology Center Atlantic FX This research was performed while the authors M. A. Vincenti and D. de Ceglia held a National Research Council Research Associateship award at the U.S. Army Aviation and Missile Research Development and Engineering Center. M. Grande thanks the U.S. Army International Technology Center Atlantic for financial support. NR 25 TC 5 Z9 5 U1 2 U2 47 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JAN 7 PY 2013 VL 113 IS 1 AR 013103 DI 10.1063/1.4772725 PG 5 WC Physics, Applied SC Physics GA 067XQ UT WOS:000313329000004 ER PT J AU Douglas, TA Blum, JD Guo, LD Keller, K Gleason, JD AF Douglas, Thomas A. Blum, Joel D. Guo, Laodong Keller, Katy Gleason, James D. TI Hydrogeochemistry of seasonal flow regimes in the Chena River, a subarctic watershed draining discontinuous permafrost in interior Alaska (USA) SO CHEMICAL GEOLOGY LA English DT Article DE Permafrost biogeochemistry; River chemistry; Nutrients; Seasonality; Weathering geochemistry ID CLIMATE-CHANGE; ORGANIC-CARBON; ISOTOPE COMPOSITION; ALPINE CATCHMENT; BOREAL FORESTS; NORTH-AMERICA; ACTIVE LAYER; TEMPERATURE; FLUXES; BIOGEOCHEMISTRY AB Thawing of permafrost and a shift in the timing of major seasonal transitions (spring melt and fall freeze-up) are two anticipated effects of climate warming in northern regions. These fundamental changes in terrestrial ecosystems could have major ramifications for the timing and fluxes of carbon and nutrient exports from watersheds and the geochemical signatures of northern rivers. Discontinuous permafrost, which underlies watersheds in Interior Alaska (USA), is expected to degrade rapidly in response to climate warming and this will likely alter subsurface flows and flow paths, water residence times, water-soil, and water-rock interactions. This study of the Chena River in Interior Alaska was undertaken to quantify dissolved organic carbon (DOC), total dissolved nitrogen (TDN), major ion, strontium isotope, and stable oxygen and hydrogen isotope values during two year-long time series sampling periods. Our goal was to identify the hydrogeochemical signatures associated with the major seasonal flow regimes. Periods of increased discharge such as spring melt and major summer precipitation events yielded elevated DOC and TON concentrations, diluted major ion concentrations, and shifted stable oxygen and hydrogen isotope ratios from base flow toward precipitation values. During dry summer periods nutrient concentrations decreased and strontium isotope values were indicative of a higher proportion of silicate versus carbonate mineral dissolution. Winter base flow had a unique geochemical signal with a slight increase in TDN concentrations compared to typical summer conditions, and a lower proportion of silicate versus carbonate mineral dissolution. Since flow paths in subarctic watersheds can change dramatically over the course of a year we interpreted our results within the context of a schematic model for subsurface flow to identify how permafrost degradation might affect nutrient exports and hydrogeochemical patterns in these watersheds. Published by Elsevier B.V. C1 [Douglas, Thomas A.] USA, Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. [Blum, Joel D.; Keller, Katy; Gleason, James D.] Univ Michigan, Dept Earth & Environm Sci, Ann Arbor, MI 48109 USA. [Guo, Laodong] Univ Wisconsin, Sch Freshwater Sci, Milwaukee, WI 53204 USA. RP Douglas, TA (reprint author), USA, Cold Reg Res & Engn Lab, POB 35170, Ft Wainwright, AK 99703 USA. EM Thomas.A.Douglas@usace.army.mil RI Guo, Laodong/F-6045-2010 OI Guo, Laodong/0000-0002-5010-1630 FU U.S. Army Alaska Directorate of Public Works FX We thank Yihua Cai, Mindy Juliana, Art Gelvin, and Laura Johnson for their assistance with field sampling. Zhengzhen Zhou helped with the DOC and TDN analysis. Amanda Barker commented on an earlier version of this manuscript. Two reviewers provided constructive comments that strengthened an earlier version of this manuscript and their efforts are greatly appreciated. Funding was provided by the U.S. Army Alaska Directorate of Public Works. Chris Hiemstra and Rainer Newberry helped us with development of the geologic map of the watershed. NR 86 TC 12 Z9 13 U1 0 U2 64 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2541 J9 CHEM GEOL JI Chem. Geol. PD JAN 6 PY 2013 VL 335 BP 48 EP 62 DI 10.1016/j.chemgeo.2012.10.045 PG 15 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 077GJ UT WOS:000314015600005 ER PT J AU Kreit, E Mathger, LM Hanlon, RT Dennis, PB Naik, RR Forsythe, E Heikenfeld, J AF Kreit, Eric Maethger, Lydia M. Hanlon, Roger T. Dennis, Patrick B. Naik, Rajesh R. Forsythe, Eric Heikenfeld, Jason TI Biological versus electronic adaptive coloration: how can one inform the other? SO JOURNAL OF THE ROYAL SOCIETY INTERFACE LA English DT Review DE adaptive coloration; reflective coloration; cephalopod; reflective displays ID AVIAN FEATHER BARBS; SQUID IRIDOPHORES; RECEPTOR NOISE; DISPLAYS; CAMOUFLAGE; CHROMATOPHORES; REFLECTANCE; MODEL; NANOSTRUCTURES; CEPHALOPODS AB Adaptive reflective surfaces have been a challenge for both electronic paper (e-paper) and biological organisms. Multiple colours, contrast, polarization, reflectance, diffusivity and texture must all be controlled simultaneously without optical losses in order to fully replicate the appearance of natural surfaces and vividly communicate information. This review merges the frontiers of knowledge for both biological adaptive coloration, with a focus on cephalopods, and synthetic reflective e-paper within a consistent framework of scientific metrics. Currently, the highest performance approach for both nature and technology uses colourant transposition. Three outcomes are envisioned from this review: reflective display engineers may gain new insights from millions of years of natural selection and evolution; biologists will benefit from understanding the types of mechanisms, characterization and metrics used in synthetic reflective e-paper; all scientists will gain a clearer picture of the long-term prospects for capabilities such as adaptive concealment and signalling. C1 [Kreit, Eric; Heikenfeld, Jason] Univ Cincinnati, Sch Elect & Comp Syst, Novel Devices Lab, Cincinnati, OH 45221 USA. [Maethger, Lydia M.; Hanlon, Roger T.] Marine Biol Lab, Woods Hole, MA 02543 USA. [Dennis, Patrick B.; Naik, Rajesh R.] USAF, Mat & Mfg Directorate, Res Lab, Dayton, OH 45433 USA. [Forsythe, Eric] USA, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA. RP Heikenfeld, J (reprint author), Univ Cincinnati, Sch Elect & Comp Syst, Novel Devices Lab, Cincinnati, OH 45221 USA. EM heikenjc@ucmail.uc.edu RI Hanlon, Roger/Q-8687-2016 OI Hanlon, Roger/0000-0003-0004-5674 FU AFRL [5408-25-SC-0003]; NSF [0640964]; NSF IHCS [1001141]; ARL [W9111NF-09-2-0034, W911NF-09-2-0043]; AFOSR [FA9550-09-0346]; DARPA (DSO) [W911NF-10-1-0113]; ONR [N00014-10-1-0989] FX E.K., J.H. and E. F. created content on technological (synthetic) aspects of adaptive coloration while L. M. M., R. T. H., P. B. D. and R.R.N. focused on the biological content. E. K. organized and compiled the sections into the main paper, and worked with J.H. on the comparisons section at the end. All authors discussed the information presented in the paper at all stages, with the exception of E. F. who made significant contributions at later stages. The University of Cincinnati authors gratefully acknowledge partial support from AFRL (contract no. 5408-25-SC-0003) NSF Career award (no. 0640964; University of Cincinnati), NSF IHCS award (no. 1001141) and ARL (grant no. W9111NF-09-2-0034). MBL authors acknowledge support from AFOSR grant no. FA9550-09-0346, ARL grant no. W911NF-09-2-0043, DARPA (DSO) grant no. W911NF-10-1-0113 and ONR grant no. N00014-10-1-0989. R.R.N. acknowledges support from AFOSR. NR 74 TC 18 Z9 18 U1 4 U2 83 PU ROYAL SOC PI LONDON PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND SN 1742-5689 EI 1742-5662 J9 J R SOC INTERFACE JI J. R. Soc. Interface PD JAN 6 PY 2013 VL 10 IS 78 AR 20120601 DI 10.1098/rsif.2012.0601 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 048UT UT WOS:000311939400013 PM 23015522 ER PT J AU Gao, GF Wieczorek, L Peachman, KK Polonis, VR Alving, CR Rao, M Rao, VB AF Gao, Guofen Wieczorek, Lindsay Peachman, Kristina K. Polonis, Victoria R. Alving, Carl R. Rao, Mangala Rao, Venigalla B. TI Designing a Soluble Near Full-length HIV-1 gp41 Trimer SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; PROXIMAL EXTERNAL REGION; BROADLY NEUTRALIZING ANTIBODIES; ENVELOPE GLYCOPROTEIN; MONOCLONAL-ANTIBODY; TYPE-1 ENVELOPE; INTEGRIN ALPHA(4)BETA(7); CONFORMATIONAL-CHANGES; IMMUNODOMINANT DOMAIN; MEMBRANE-FUSION AB The HIV-1 envelope spike is a trimer of heterodimers composed of an external glycoprotein gp120 and a transmembrane glycoprotein gp41. gp120 initiates virus entry by binding to host receptors, whereas gp41 mediates fusion between viral and host membranes. Although the basic pathway of HIV-1 entry has been extensively studied, the detailed mechanism is still poorly understood. Design of gp41 recombinants that mimic key intermediates is essential to elucidate the mechanism as well as to develop potent therapeutics and vaccines. Here, using molecular genetics and biochemical approaches, a series of hypotheses was tested to overcome the extreme hydrophobicity of HIV-1 gp41 and design a soluble near full-length gp41 trimer. The two long heptad repeat helices HR1 and HR2 of gp41 ectodomain were mutated to disrupt intramolecular HR1-HR2 interactions but not intermolecular HR1-HR1 interactions. This resulted in reduced aggregation and improved solubility. Attachment of a 27-amino acid foldon at the C terminus and slow refolding channeled gp41 into trimers. The trimers appear to be stabilized in a prehairpin-like structure, as evident from binding of a HR2 peptide to exposed HR1 grooves, lack of binding to hexa-helical bundle specific NC-1 mAb, and inhibition of virus neutralization by broadly neutralizing antibodies 2F5 and 4E10. Fusion to T4 small outer capsid protein, Soc, allowed display of gp41 trimers on the phage nanoparticle. These approaches for the first time led to the design of a soluble gp41 trimer containing both the fusion peptide and the cytoplasmic domain, providing insights into the mechanism of entry and development of gp41-based HIV-1 vaccines. C1 [Gao, Guofen; Rao, Venigalla B.] Catholic Univ Amer, Dept Biol, Washington, DC 20064 USA. [Wieczorek, Lindsay; Peachman, Kristina K.] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Polonis, Victoria R.; Alving, Carl R.; Rao, Mangala] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. RP Rao, VB (reprint author), Catholic Univ Amer, Dept Biol, 620 Michigan Ave NE, Washington, DC 20064 USA. EM rao@cua.edu FU National Institutes of Health [R01AI02725 (NIAID)] FX This work was supported in part by National Institutes of Health Grant R01AI02725 (NIAID). NR 69 TC 8 Z9 8 U1 1 U2 44 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD JAN 4 PY 2013 VL 288 IS 1 BP 234 EP 246 DI 10.1074/jbc.M112.424432 PG 13 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 066CJ UT WOS:000313197200023 PM 23184960 ER PT J AU Xing, LD Vatamanu, J Borodin, O Bedrov, D AF Xing, Lidan Vatamanu, Jenel Borodin, Oleg Bedrov, Dmitry TI On the Atomistic Nature of Capacitance Enhancement Generated by Ionic Liquid Electrolyte Confined in Subnanometer Pores SO JOURNAL OF PHYSICAL CHEMISTRY LETTERS LA English DT Article ID DOUBLE-LAYER CAPACITORS; MOLECULAR-DYNAMICS SIMULATION; DIFFERENTIAL CAPACITANCE; ELECTROCHEMICAL CAPACITORS; GRAPHITE-ELECTRODES; SIZE; CARBONS; SURFACE; SUPERCAPACITOR; NANOPORE AB The capacitance enhancement experimentally observed in electrodes with complex morphology of random subnanometer wide pores is an intriguing phenomena, yet the mechanisms for such enhancement are not completely understood. Our atomistic molecular dynamics simulations demonstrate that in subnanometer slit-geometry nanopores, a factor of 2 capacitance enhancement (compared to a flat electrode) is possible for the 1-ethyl-3-methylimidazolium (EMIM)-bis(trifluoro-methylsulfonyl)imide (TFSI) ionic liquid electrolyte. This capacitance enhancement is a result of a fast charge separation inside the nanopore due to abrupt expulsion of co-ions from the pore while maintaining an elevated counterion density due to strong screening of electrostatic repulsive interactions by the conductive pore. Importantly, we find that the capacitance enhancement can be very asymmetric. For the negatively charged 7.5 angstrom wide pore, the integral capacitance is 100% larger than on a flat surface; however, on the positive electrode, almost no enhancement is observed. Detailed analysis of structure and composition of electrolyte inside nanopores shows that the capacitance enhancement and the shape of differential capacitance details of the ion chemical structure and a delicate balance of ion surface and ion ion interactions. strongly depend on the details of the ion chemical structure and a delicate balance of ion-surface and ion-ion interactions. C1 [Xing, Lidan; Vatamanu, Jenel; Bedrov, Dmitry] Univ Utah, Dept Mat Sci & Engn, Salt Lake City, UT 84112 USA. [Xing, Lidan] S China Normal Univ, Sch Chem & Environm, Guangzhou 510006, Guangdong, Peoples R China. [Borodin, Oleg] USA, Electrochem Branch, Res Lab, Adelphi, MD 20783 USA. RP Vatamanu, J (reprint author), Univ Utah, Dept Mat Sci & Engn, 122 S Cent Campus Dr, Salt Lake City, UT 84112 USA. EM vatamanu.jenel@utah.edu; d.bedrov@utah.edu RI Borodin, Oleg/B-6855-2012; Vatamanu, Jenel/I-7638-2012 OI Borodin, Oleg/0000-0002-9428-5291; Vatamanu, Jenel/0000-0003-0825-1608 FU Department of Energy [DE-SC0001912]; Office of Science of the U.S. Department of Energy [DE-AC02-05CH11231]; Natural Science Foundation of Guangdong Province, China [1035106310 1000001] FX The authors are grateful to the Department of Energy under Contract Grant DE-SC0001912 to the University of Utah. This research used computational resources of the National Energy Research Scientific Computing Center, which is supported by the Office of Science of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. L.X. acknowledges financial support of the Natural Science Foundation of Guangdong Province, China (grant no. 1035106310 1000001). NR 43 TC 48 Z9 50 U1 8 U2 142 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1948-7185 J9 J PHYS CHEM LETT JI J. Phys. Chem. Lett. PD JAN 3 PY 2013 VL 4 IS 1 BP 132 EP 140 DI 10.1021/jz301782f PG 9 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Atomic, Molecular & Chemical SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 065IM UT WOS:000313142000023 PM 26291225 ER PT J AU Takala-Harrison, S Clark, TG Jacob, CG Cummings, MP Miotto, O Dondorp, AM Fukuda, MM Nosten, F Noedl, H Imwong, M Bethell, D Se, Y Lon, C Tyner, SD Saunders, DL Socheat, D Ariey, F Phyo, AP Starzengruber, P Fuehrer, HP Swoboda, P Stepniewska, K Flegg, J Arze, C Cerqueira, GC Silva, JC Ricklefs, SM Porcella, SF Stephens, RM Adams, M Kenefic, LJ Campino, S Auburn, S Macinnis, B Kwiatkowski, DP Su, XZ White, NJ Ringwald, P Plowe, CV AF Takala-Harrison, Shannon Clark, Taane G. Jacob, Christopher G. Cummings, Michael P. Miotto, Olivo Dondorp, Arjen M. Fukuda, Mark M. Nosten, Francois Noedl, Harald Imwong, Mallika Bethell, Delia Se, Youry Lon, Chanthap Tyner, Stuart D. Saunders, David L. Socheat, Duong Ariey, Frederic Phyo, Aung Pyae Starzengruber, Peter Fuehrer, Hans-Peter Swoboda, Paul Stepniewska, Kasia Flegg, Jennifer Arze, Cesar Cerqueira, Gustavo C. Silva, Joana C. Ricklefs, Stacy M. Porcella, Stephen F. Stephens, Robert M. Adams, Matthew Kenefic, Leo J. Campino, Susana Auburn, Sarah Macinnis, Bronwyn Kwiatkowski, Dominic P. Su, Xin-zhuan White, Nicholas J. Ringwald, Pascal Plowe, Christopher V. TI Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE drug resistance; genome-wide association; molecular markers ID GENOME-WIDE; POPULATION-STRUCTURE; PARASITE CLEARANCE; POSITIVE SELECTION; RESISTANT MALARIA; WESTERN CAMBODIA; ARTESUNATE; MEFLOQUINE; REGIONS; LIGHT AB The recent emergence of artemisinin-resistant Plasmodium falciparum malaria in western Cambodia could threaten prospects for malaria elimination. Identification of the genetic basis of resistance would provide tools for molecular surveillance, aiding efforts to contain resistance. Clinical trials of artesunate efficacy were conducted in Bangladesh, in northwestern Thailand near the Myanmar border, and at two sites in western Cambodia. Parasites collected from trial participants were genotyped at 8,079 single nucleotide polymorphisms (SNPs) using a P. falciparum-specific SNP array. Parasite genotypes were examined for signatures of recent positive selection and association with parasite clearance phenotypes to identify regions of the genome associated with artemisinin resistance. Four SNPs on chromosomes 10 (one), 13 (two), and 14 (one) were significantly associated with delayed parasite clearance. The two SNPs on chromosome 13 are in a region of the genome that appears to be under strong recent positive selection in Cambodia. The SNPs on chromosomes 10 and 13 lie in or near genes involved in postreplication repair, a DNA damage-tolerance pathway. Replication and validation studies are needed to refine the location of loci responsible for artemisinin resistance and to understand the mechanism behind it; however, two SNPs on chromosomes 10 and 13 may be useful markers of delayed parasite clearance in surveillance for artemisinin resistance in Southeast Asia. C1 [Takala-Harrison, Shannon; Jacob, Christopher G.; Adams, Matthew; Kenefic, Leo J.; Plowe, Christopher V.] Univ Maryland, Sch Med, Howard Hughes Med Inst, Ctr Vaccine Dev, Baltimore, MD 21201 USA. [Clark, Taane G.] London Sch Trop Med, Dept Pathogen Mol Biol, London WC1E 7HT, England. [Cummings, Michael P.] Univ Maryland, Ctr Bioinformat & Computat Biol, College Pk, MD 20742 USA. [Miotto, Olivo; Campino, Susana; Macinnis, Bronwyn; Kwiatkowski, Dominic P.] Univ Oxford, Med Res Council Ctr Genom & Global Hlth, Oxford OX3 7BN, England. [Miotto, Olivo; Dondorp, Arjen M.; Nosten, Francois; Phyo, Aung Pyae; White, Nicholas J.] Mahidol Univ, Fac Trop Med, Mahidol Oxford Res Unit, Bangkok 10400, Thailand. [Fukuda, Mark M.; Bethell, Delia; Tyner, Stuart D.; Saunders, David L.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Nosten, Francois; Phyo, Aung Pyae] Shoklo Malaria Res Unit, Mae Sot 63110, Tak, Thailand. [Noedl, Harald; Starzengruber, Peter; Fuehrer, Hans-Peter; Swoboda, Paul] Med Univ Vienna, Inst Specif Prophylaxis & Trop Med, A-1090 Vienna, Austria. [Imwong, Mallika] Mahidol Univ, Fac Trop Med, Dept Mol Trop Med & Genet, Bangkok 10400, Thailand. [Se, Youry; Lon, Chanthap] Armed Forces Res Inst Med Sci, Phnom Penh 12252, Cambodia. [Socheat, Duong] Univ Hlth Sci, Phnom Penh 12201, Cambodia. [Ariey, Frederic] Inst Pasteur, Unite Immunol Mol Parasites, F-75015 Paris, France. [Stepniewska, Kasia; Flegg, Jennifer] Univ Oxford, WorldWide Antimalarial Resistance Network, Oxford OX3 7LJ, England. [Arze, Cesar; Cerqueira, Gustavo C.; Silva, Joana C.] Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA. [Ricklefs, Stacy M.; Porcella, Stephen F.] NIAID, Res Technol Branch, Rocky Mt Labs, NIH, Hamilton, MT 59840 USA. [Stephens, Robert M.] Adv Biomed Comp Ctr, Frederick, MD 21702 USA. [Campino, Susana; Auburn, Sarah; Macinnis, Bronwyn; Kwiatkowski, Dominic P.] Wellcome Trust Sanger Inst, Malaria Programme, Hinxton CB10 1SA, England. [Su, Xin-zhuan] NIAID, Lab Malaria & Vector Res, NIH, Bethesda, MD 20892 USA. [Ringwald, Pascal] CERN, Drug Resistance & Containment Unit, Global Malaria Programme, CH-1211 Geneva 27, Switzerland. RP Plowe, CV (reprint author), Univ Maryland, Sch Med, Howard Hughes Med Inst, Ctr Vaccine Dev, Baltimore, MD 21201 USA. EM cplowe@medicine.umaryland.edu RI Valle, Ruben/A-7512-2013; Ward, Steve/G-6003-2015; OI Ward, Steve/0000-0003-2331-3192; Auburn, Sarah/0000-0002-4638-536X; Kwiatkowski, Dominic/0000-0002-5023-0176; Pyae Phyo, Aung/0000-0002-0383-9624 FU Bill and Melinda Gates Foundation; Howard Hughes Medical Institute; Doris Duke Charitable Foundation; Division of Intramural Research, National Institute for Allergy and Infectious Diseases; National Institutes of Health (NIH) [IH K12RR023250]; National Cancer Institute and NIH [HHSN261200800001E]; Centre for Genomics and Global Health by the Medical Research Council [G19/9, G0600230, G0600718]; Wellcome Trust [077012/Z/05/Z, 098051]; Resource Centre for Genomic Epidemiology of Malaria [090770/Z/09/Z] FX This work was supported by the Bill and Melinda Gates Foundation; the Howard Hughes Medical Institute; the Doris Duke Charitable Foundation; the Division of Intramural Research, National Institute for Allergy and Infectious Diseases; National Institutes of Health (NIH) Grant IH K12RR023250 (to S. T.-H.); National Cancer Institute and NIH Contract HHSN261200800001E (to R. M. S.); and Centre for Genomics and Global Health by the Medical Research Council Grants G19/9, G0600230, and G0600718 (to D. P. K. and O.M.). The Wellcome Trust provides core support to the Wellcome Trust Sanger Institute under Contract 077012/Z/05/Z, 098051, and the Resource Centre for Genomic Epidemiology of Malaria Contract 090770/Z/09/Z. NR 34 TC 126 Z9 127 U1 1 U2 50 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD JAN 2 PY 2013 VL 110 IS 1 BP 240 EP 245 DI 10.1073/pnas.1211205110 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 071XI UT WOS:000313630300057 PM 23248304 ER PT S AU Hsieh, B Ratcliff, J AF Hsieh, Bernard Ratcliff, Jay BE Iliadis, L Papadopoulos, H Jayne, C TI Coastal Hurricane Inundation Prediction for Emergency Response Using Artificial Neural Networks SO ENGINEERING APPLICATIONS OF NEURAL NETWORKS, EANN 2013, PT I SE Communications in Computer and Information Science LA English DT Proceedings Paper CT 14th International Conference on Engineering Applications of Neural Networks (EANN) CY SEP 13-16, 2013 CL Halkidiki, GREECE DE Storm Surge Prediction; surrogate modeling; neural networks; multilayer perceptron ID TERM STORM-SURGE AB Emergency managers require both fast and accurate estimates of hurricane inundation to make critical decisions about evacuations, structure closures, and other emergency response activities before, during, and after events. Probability analyses require multiple simulations which, generally, cannot be performed with the physics-based models under the time constraints during emergency conditions. To obtain highly accurate results with a fast turnaround computation time a "surrogate" modeling approach is employed. This surrogate modeling approach uses an extensive database of storms and storm responses and applies "smart" pattern recognition tools such as Artificial Neural Networks (ANN) as well as interpolation techniques. The goal is to provide forecasts of hurricane inundation and waves with the accuracy of high-resolution, high-fidelity models but with very short execution time (minutes). The city of New Orleans as well as surrounding municipalities along the Gulf of Mexico coastal area encompasses the region used to demonstrate this approach. The results indicate that the developed surge prediction tool could be used to forecast both magnitude and duration to peak surge for multiple selected points in a few minutes of computational time once the storm parameters are provided. In this paper, only results of surge magnitude are presented. C1 [Hsieh, Bernard; Ratcliff, Jay] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Hsieh, B (reprint author), US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM hsiehb@wes.army.mil NR 9 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 1865-0929 BN 978-3-642-41012-3; 978-3-642-41013-0 J9 COMM COM INF SC PY 2013 VL 383 BP 102 EP 111 PG 10 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems; Computer Science, Theory & Methods SC Computer Science GA BB7CI UT WOS:000345333800011 ER PT B AU Palmer-Moloney, LJ AF Palmer-Moloney, Laura Jean BE Weinthal, E Troell, J Nakayama, M TI Water's role in measuring security and stability in Helmand Province, Afghanistan SO WATER AND POST-CONFLICT PEACEBUILDING LA English DT Article; Book Chapter C1 [Palmer-Moloney, Laura Jean] US Army Corps Engineers, Engineer Res & Dev Ctr, Alexandria, VA 22315 USA. RP Palmer-Moloney, LJ (reprint author), US Army Corps Engineers, Engineer Res & Dev Ctr, Alexandria, VA 22315 USA. NR 47 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE PI LONDON PA 11 NEW FETTER LANE, LONDON EC4P 4EE, ENGLAND BN 978-1-84971-232-3; 978-1-84977-580-9 PY 2013 BP 211 EP 235 PG 25 WC Environmental Studies; International Relations; Planning & Development SC Environmental Sciences & Ecology; International Relations; Public Administration GA BB5TI UT WOS:000344088700015 ER PT B AU Dehgan, A Palmer-Moloney, LJ Mirzaee, M AF Dehgan, Alex Palmer-Moloney, Laura Jean Mirzaee, Mehdi BE Weinthal, E Troell, J Nakayama, M TI Water security and scarcity: Potential destabilization in western Afghanistan and Iranian Sistan and Baluchestan due to transboundary water conflicts SO WATER AND POST-CONFLICT PEACEBUILDING LA English DT Article; Book Chapter C1 [Dehgan, Alex] US Agcy Int Dev, Washington, DC 20523 USA. [Palmer-Moloney, Laura Jean] US Army Corps Engineers, Engineer Res & Dev Ctr, Washington, DC USA. [Mirzaee, Mehdi] Islamic Azad Univ, Cent Tehran Branch, Tehran, Iran. [Mirzaee, Mehdi] Oregon State Univ, Dept Geosci, Ctr Water Conflict Management, Corvallis, OR 97331 USA. RP Dehgan, A (reprint author), US Agcy Int Dev, Washington, DC 20523 USA. NR 63 TC 1 Z9 1 U1 0 U2 0 PU ROUTLEDGE PI LONDON PA 11 NEW FETTER LANE, LONDON EC4P 4EE, ENGLAND BN 978-1-84971-232-3; 978-1-84977-580-9 PY 2013 BP 305 EP 326 PG 22 WC Environmental Studies; International Relations; Planning & Development SC Environmental Sciences & Ecology; International Relations; Public Administration GA BB5TI UT WOS:000344088700021 ER PT B AU Lambert, B Miller, C Ogard, L Ritchey, B AF Lambert, Bruce Miller, Chad Ogard, Libby Ritchey, Ben BE Bergqvist, R Wilmsmeier, G Cullinane, K TI Observations on the Potential for Dry Port Terminal Developments in the United States SO DRY PORTS - A GLOBAL PERSPECTIVE: CHALLENGES AND DEVELOPMENTS IN SERVING HINTERLANDS SE Transport and Society LA English DT Article; Book Chapter C1 [Lambert, Bruce] Inst Trade & Transportat Studies, New Orleans, LA 70130 USA. [Lambert, Bruce] US Army Corps Engineers, Inst Water Resources, Washington, DC USA. [Lambert, Bruce] Int Nav Assoc PIANC, US Sect, Alexandria, VA USA. [Lambert, Bruce] Fed Highway Adm, Washington, DC USA. [Lambert, Bruce] Louisiana State Univ, Baton Rouge, LA 70803 USA. [Miller, Chad] Univ So Mississippi, Dept Econ & Workforce Dev, Hattiesburg, MS 39406 USA. [Ogard, Libby] Prime Focus LLC, De Pere, WI USA. [Ogard, Libby] Prime Focus LLC, Retail Div, De Pere, WI USA. [Ritchey, Ben] US DOT, Washington, DC USA. [Ritchey, Ben] US DOE, Washington, DC 20585 USA. RP Lambert, B (reprint author), Inst Trade & Transportat Studies, New Orleans, LA 70130 USA. NR 25 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-4425-1; 978-1-4094-4424-4 J9 TRANSP SOC PY 2013 BP 173 EP 195 PG 23 WC Transportation SC Transportation GA BB4WP UT WOS:000343418900010 ER PT B AU Monios, J Lambert, B AF Monios, Jason Lambert, Bruce BE Bergqvist, R Wilmsmeier, G Cullinane, K TI Intermodal Freight Corridor Development in The United States SO DRY PORTS - A GLOBAL PERSPECTIVE: CHALLENGES AND DEVELOPMENTS IN SERVING HINTERLANDS SE Transport and Society LA English DT Article; Book Chapter ID PORT COMPETITION C1 [Monios, Jason] Edinburgh Napier Univ, TRI, Edinburgh, Midlothian, Scotland. [Lambert, Bruce] US Army Corps Engineers, Inst Water Resources, Washington, DC USA. [Lambert, Bruce] Int Nav Assoc PIANC, US Sect, Brussels, Belgium. [Lambert, Bruce] Fed Highway Adm, Washington, DC USA. [Lambert, Bruce] IHS Global Insight, Port Long Beach, Long Beach, CA USA. [Lambert, Bruce] Louisiana State Univ, Baton Rouge, LA 70803 USA. RP Monios, J (reprint author), Edinburgh Napier Univ, TRI, Edinburgh, Midlothian, Scotland. NR 23 TC 2 Z9 2 U1 1 U2 1 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-4425-1; 978-1-4094-4424-4 J9 TRANSP SOC PY 2013 BP 197 EP 218 PG 22 WC Transportation SC Transportation GA BB4WP UT WOS:000343418900011 ER PT S AU Yu, JJ Cali, J Zhao, F Dai, FF Jin, X Pukish, M Jin, YH Hubbard, Z Irwin, JD Jaeger, RC Aklian, A AF Yu, Jianjun Cali, Joseph Zhao, Feng Dai, Fa Foster Jin, Xin Pukish, Michael Jin, Yuehai Hubbard, Zachary Irwin, J. David Jaeger, Richard C. Aklian, Andre GP IEEE TI A Direct Digital Synthesis Based Chirp Radar Transmitter in 0.13 mu m SiGe Technology SO 2013 IEEE BIPOLAR/BICMOS CIRCUITS AND TECHNOLOGY MEETING (BCTM) SE IEEE Bipolar BiCMOS Circuits and Technology Meeting LA English DT Proceedings Paper CT IEEE Bipolar/BiCMOS Circuits and Technology Meeting (BCTM) CY SEP 30-OCT 03, 2013 CL Bordeaux, FRANCE SP IEEE, Analog Devices, IBM, Maxim, NXP, RFMD, Tektronix, Anadigics, Microsemi, Skyworks, Texas Instruments DE Direct digital synthesis (DDS); Chirp; FMCW; Radar; Transmitter ID CMOS TRANSCEIVER; FMCW RADAR AB This paper presents an X-band direct digital synthesis (DDS) based chirp radar transmitter implemented in 0.13 mu m SiGe BiCMOS technology. The transmitter contains a quadrature DDS, two low-pass filters, an IF IQ modulator, a programmable gain amplifier (PGA), a RF mixer and a pre-amplifier. The DDSs, built with two digital-to-analog converters (DACs), generate two-channel IQ baseband chirp signals from 62MHz to 77MHz. The IQ chirp signals are filtered by two programmable 5th-order Butterworth filters before up-converted to the IF frequency with IQ modulators. The filtered IF signal is further up-converted to the desired radio frequency by an RF mixer. The proposed transmitter thus generates a chirp signal at 8.6GHz, consuming a total power of 333 mW from 2.2V and 1.5V power supplies. C1 [Yu, Jianjun; Cali, Joseph; Zhao, Feng; Dai, Fa Foster; Jin, Xin; Pukish, Michael; Jin, Yuehai; Hubbard, Zachary; Irwin, J. David; Jaeger, Richard C.] Auburn Univ, Dept Elect & Comp Engn, Auburn, AL 36849 USA. [Aklian, Andre] US Army Res, RDECOM CERDEC Intelligence & Informat, Los Angeles, CA USA. RP Yu, JJ (reprint author), Auburn Univ, Dept Elect & Comp Engn, Auburn, AL 36849 USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1088-9299 BN 978-1-4799-0129-6 J9 IEEE BIPOL BICMOS PY 2013 BP 41 EP 44 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA BB3AW UT WOS:000342622100010 ER PT J AU Melby, JA Nadal, NC Males, RM AF Melby, Jeffrey A. Nadal, Norberto C. Males, Richard M. BE Takahashi, S Kobayashi, N Shimosako, KI TI CSsim: BREAKWATER-HARBOR TIME-DEPENDENT LIFE-CYCLE ANALYSIS SOFTWARE SO COASTAL STRUCTURES 2011, VOL 1 & 2 LA English DT Proceedings Paper CT 6th International Conference on Coastal Structures CY SEP 06-08, 2011 CL Yokohama, JAPAN SP ASCE COPRI, Kajima Fdn ID WAVE RUNUP AB Time-dependent life-cycle analysis of breakwater projects is addressed in new software CSsim. The system provides tools for risk assessments of breakwater/harbor projects. Recent innovations within this system include improvements to the time-dependent breakwater profile evolution, in-stream computation of wave diffraction, and consequence analysis. Companion software called StormSim provides tools for extremal probabilistic analysis of storm parameters and simulation of future wave, wind, and water level storm life cycles. StormSim simulation strategy employs a traditional Monte Carlo simulation of future offshore storm life cycles based on repeated sampling from joint probability distributions. The modeled storm characteristics include typical wave and water level parameters, storm hydrograph, relative phasing between parameters, tidal influences, and storm time-of-year. Climate change issues are addressed. Storm wave life cycles are transformed to nearshore using a table lookup. The historical and simulated nearshore wave and water level time series are used within CSsim to determine structure damage and wave transmission for a traditional multilayer rubble mound breakwater using innovative time-dependent process modeling. Wave transmission into the bay is computed for historical and simulated storm time series. The consequences, such as downtime for the harbor or channel and damage to infrastructure, are determined for breakwater repair alternatives. The probabilities of exceeding damage limit states are also computed. The method provides a basis for selecting the least-cost alternative for rehabilitation or new construction. C1 [Melby, Jeffrey A.; Nadal, Norberto C.] US Army Engineer R&D Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. [Males, Richard M.] RMM Tech Serv, Cincinnati, OH USA. RP Melby, JA (reprint author), US Army Engineer R&D Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. NR 8 TC 0 Z9 0 U1 1 U2 2 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE BN 978-981-4412-20-9 PY 2013 BP 649 EP 658 PG 10 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA BB2TO UT WOS:000342302100056 ER PT J AU Arp, R Decker, KS AF Arp, Robert Decker, Kevin S. BE Arp, R Decker, KS TI "Well, I'm Afraid It's About to Happen Again" Introducing The Ultimate South Park and Philosophy Introduction SO ULTIMATE SOUTH PARK AND PHILOSOPHY: RESPECT MY PHILOSOPHAH! SE Blackwell Philosophy and Pop Culture Series LA English DT Editorial Material; Book Chapter C1 [Arp, Robert] US Army, Washington, DC 20301 USA. [Decker, Kevin S.] Eastern Washington Univ, Philosophy Program, Spokane, WA USA. RP Arp, R (reprint author), US Army, Washington, DC 20301 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA BN 978-1-118-38656-9 J9 BLACKWELL PHILOS POP PY 2013 BP 1 EP 4 D2 10.1002/9781118607442 PG 4 WC Philosophy SC Philosophy GA BB2OI UT WOS:000341973000001 ER PT J AU Arp, R AF Arp, Robert BE Arp, R Decker, KS TI Dude, Listen to Reason! Logic Lessons Inside and Outside South Park SO ULTIMATE SOUTH PARK AND PHILOSOPHY: RESPECT MY PHILOSOPHAH! SE Blackwell Philosophy and Pop Culture Series LA English DT Article; Book Chapter C1 US Army, Washington, DC 20301 USA. RP Arp, R (reprint author), US Army, Washington, DC 20301 USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA BN 978-1-118-38656-9 J9 BLACKWELL PHILOS POP PY 2013 BP 41 EP 52 D2 10.1002/9781118607442 PG 12 WC Philosophy SC Philosophy GA BB2OI UT WOS:000341973000005 ER PT B AU Bradbury-Huang, H Long, K AF Bradbury-Huang, Hilary Long, Ken BE Stevenson, RB Brody, M Dillon, J Wals, AEJ TI Collaborative Ecological Inquiry Where Action Research Meets Sustainable Development SO INTERNATIONAL HANDBOOK OF RESEARCH ON ENVIRONMENTAL EDUCATION LA English DT Article; Book Chapter C1 [Bradbury-Huang, Hilary] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Long, Ken] US Army Command, Ft Bragg, NC USA. [Long, Ken] Gen Staff Coll, Leavenworth, KS USA. RP Bradbury-Huang, H (reprint author), Oregon Hlth & Sci Univ, Portland, OR 97201 USA. NR 46 TC 0 Z9 0 U1 0 U2 1 PU ROUTLEDGE PI LONDON PA 11 NEW FETTER LANE, LONDON EC4P 4EE, ENGLAND BN 978-0-415-89239-1; 978-0-203-81333-1; 978-0-415-89238-4 PY 2013 BP 459 EP 468 PG 10 WC Education & Educational Research; Environmental Studies SC Education & Educational Research; Environmental Sciences & Ecology GA BB1TF UT WOS:000341355100051 ER PT J AU Sensoy, M de Mel, G Kaplan, L Pham, T Norman, TJ AF Sensoy, Murat de Mel, Geeth Kaplan, Lance Tien Pham Norman, Timothy J. GP IEEE TI TRIBE: Trust Revision for Information Based on Evidence SO 2013 16TH INTERNATIONAL CONFERENCE ON INFORMATION FUSION (FUSION) LA English DT Proceedings Paper CT 16th International Conference on Information Fusion (FUSION) CY JUL 09-12, 2013 CL Istanbul, TURKEY SP HAVELSAN, METEKSAN SAVUNMA, TUBITAK, METRON Sci Solut, Off Naval Res Global Sci & Technol, Ankara Univ, Sabanci Univ, STM, TAI, ASELSAN, Koc Bilgi Savunma Teknolojileri A S, Kale Havacilik, Int Soc Infromat Fus, IEEE, AESS DE Information Fusion; Trust; Constraint Optimisation; Subjective Logic; Dempster-Shafer Theory of Evidence ID REPUTATION AB In recent years, the number of information sources available to support decision-making has increased dramatically. However, more information sources do not always mean higher precision in the fused information. This is partially due to the fact that some of these sources may be erroneous or malicious. Therefore, it is critical to asses the trust in information before performing fusion. To estimate trust in information, existing approaches use trustworthiness of its source as a proxy. We argue that conflicts between information may also serve as evidence to reduce trust in information. In this paper, we use subjective opinions to represent information from diverse sources. We propose to exploit conflicts between opinions to revise their trustworthiness. For this purpose, we formalise trust revision as a constraint optimisation problem. Through extensive empirical studies, we show that our approach significantly outperform existing ones in the face of malicious information sources. C1 [Sensoy, Murat] Ozyegin Univ, Dept Comp Sci, Istanbul, Turkey. [Sensoy, Murat; Norman, Timothy J.] Univ Aberdeen, Dept Comp Sci, Aberdeen AB9 1FX, Scotland. [de Mel, Geeth; Kaplan, Lance; Tien Pham] US Army, Res Lab, Adelphi, MD 20783 USA. [de Mel, Geeth] IBM TJ Watson Res Ctr, Hawthorne, NY USA. RP Sensoy, M (reprint author), Ozyegin Univ, Dept Comp Sci, Istanbul, Turkey. FU U.S. Army Research Laboratory; U.K. Ministry of Defence [W911NF-06-3-0001]; The Scientific and Technological Research Council of Turkey (TUBITAK) [111K476] FX Research was sponsored by the U.S. Army Research Laboratory and the U.K. Ministry of Defence and was accomplished under Agreement Number W911NF-06-3-0001. The views and conclusions contained in this document are those of the author(s) and should not be interpreted as representing the official policies, either expressed or implied, of the U.S. Army Research Laboratory, the U.S. Government, the U.K. Ministry of Defence or the U.K. Government. The U.S. and U.K. Governments are authorised to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. Dr. Sensoy thanks to The Scientific and Technological Research Council of Turkey (TUBITAK) for its support under grant 111K476. NR 15 TC 4 Z9 4 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-605-86311-1-3 PY 2013 BP 914 EP 921 PG 8 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BB1UM UT WOS:000341370000122 ER PT J AU Damarla, T Kaplan, LM AF Damarla, Thyagaraju Kaplan, Lance M. GP IEEE TI A Fusion Architecture for Tracking a Group of People using a Distributed Sensor Network SO 2013 16TH INTERNATIONAL CONFERENCE ON INFORMATION FUSION (FUSION) LA English DT Proceedings Paper CT 16th International Conference on Information Fusion (FUSION) CY JUL 09-12, 2013 CL Istanbul, TURKEY SP HAVELSAN, METEKSAN SAVUNMA, TUBITAK, METRON Sci Solut, Off Naval Res Global Sci & Technol, Ankara Univ, Sabanci Univ, STM, TAI, ASELSAN, Koc Bilgi Savunma Teknolojileri A S, Kale Havacilik, Int Soc Infromat Fus, IEEE, AESS DE Personnel detection; decentralized fusion; tracking; non-negative matrix factorization; classification; basis vectors ID NONNEGATIVE MATRIX FACTORIZATION; SYSTEMS AB This paper presents an architecture to fuse the information from different spatially distributed unattended ground sensors (UGSs) consisting of multiple modalities to track a group of people walking along trails in open areas. The UGS system we used consists of ultrasonic, seismic and passive infrared (PIR) sensors. Estimating the size of the group is done by counting the number of targets using ultrasonic sensors. Determining the composition of the group is done using several classifiers. The fusion is done at the UGS level to fuse information from all the modalities to determine the presence of a target(s) and the information from multiple UGS systems are fused to track a group. The algorithms are tested on data collected in the wilderness with three UGS systems separated 75 m apart on a trail. C1 [Damarla, Thyagaraju; Kaplan, Lance M.] US Army Res Lab, Adelphi, MD 20783 USA. RP Damarla, T (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM thyagaraju.damarla.civ@mail.mil; lance.m.kaplan.civ@mail.mil NR 12 TC 0 Z9 0 U1 0 U2 3 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-605-86311-1-3 PY 2013 BP 1776 EP 1783 PG 8 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BB1UM UT WOS:000341370000236 ER PT J AU Kaplan, LM Sensoy, M Tang, YQ Chakraborty, S Bisdikian, C de Mel, G AF Kaplan, Lance M. Sensoy, Murat Tang, Yuqing Chakraborty, Supriyo Bisdikian, Chatschik de Mel, Geeth GP IEEE TI Reasoning Under Uncertainty: Variations of Subjective Logic Deduction SO 2013 16TH INTERNATIONAL CONFERENCE ON INFORMATION FUSION (FUSION) LA English DT Proceedings Paper CT 16th International Conference on Information Fusion (FUSION) CY JUL 09-12, 2013 CL Istanbul, TURKEY SP HAVELSAN, METEKSAN SAVUNMA, TUBITAK, METRON Sci Solut, Off Naval Res Global Sci & Technol, Ankara Univ, Sabanci Univ, STM, TAI, ASELSAN, Koc Bilgi Savunma Teknolojileri A S, Kale Havacilik, Int Soc Infromat Fus, IEEE, AESS AB This work develops alternatives to the classical subjective logic deduction operator. Given antecedent and consequent propositions, the new operators form opinions of the consequent that match the variance of the consequent posterior distribution given opinions on the antecedent and the conditional rules connecting the antecedent with the consequent. As a result, the uncertainty of the consequent actually map to the spread for the probability projection of the opinion. Monte Carlo simulations demonstrate this connection for the new operators. Finally, the work uses Monte Carlo simulations to evaluate the quality of fusing opinions from multiple agents before and after deduction. C1 [Kaplan, Lance M.; de Mel, Geeth] US Army Res Lab, Adelphi, MD 20783 USA. [Sensoy, Murat] Ozyegin Univ, Istanbul, Turkey. [Sensoy, Murat] Univ Aberdeen, Aberdeen AB9 1FX, Scotland. [Tang, Yuqing] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA. [Chakraborty, Supriyo] Univ Calif Los Angeles, Los Angeles, CA 90024 USA. [Bisdikian, Chatschik; de Mel, Geeth] IBM Res, T J Watson Res Ctr, Yorktown Hts, NY USA. RP Kaplan, LM (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. FU U.S. Army Research Laboratory; U.K Ministry of Defense FX Research was sponsored by the U.S. Army Research Laboratory and the U.K Ministry of Defense and was accomplished under Agreement Number W911NF-06-3-0001. The views and conclusions contained in this document are those of the authors and should not be interpreted as repr esenting the official policies, either expressed or implied, of the U.S Ar my Research Laboratory, the U.S. Government, the U.K. Ministry of Defen se or the U.K Government. The U.S. and U.K. Governments are authorized to reproduce and distribute for Government purposes notwithstanding any co pyright notation hereon. NR 12 TC 1 Z9 1 U1 0 U2 4 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-605-86311-1-3 PY 2013 BP 1910 EP 1917 PG 8 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BB1UM UT WOS:000341370000254 ER PT S AU Cohn, MB Saechao, K Whitlock, M Brenman, D Tang, WT Proie, RM AF Cohn, Michael B. Saechao, Kaosio Whitlock, Michael Brenman, Daniel Tang, Wallace T. Proie, Robert M., Jr. GP IEEE TI RF MEMS Switches for Wide I/O Data Bus Applications SO 2013 IEEE INTERNATIONAL TEST CONFERENCE (ITC) SE International Test Conference Proceedings LA English DT Proceedings Paper CT IEEE International Test Conference (ITC) CY SEP 10-12, 2013 CL Anaheim, CA SP IEEE Comp Soc, Test Technol Tech Council, IEEE Philadelphia Sect DE TSV; Wide I/O; MEMS Switch; ATE; Switch Matrix; Relay AB Wide I/O poses serious challenges due to the requisite high density of electronics and relays near the DUT, as well as high bandwidth. A 2x2mm MEMS switch has been demonstrated, offering >80% footprint reduction relative to a typical TO-can electromagnetic relay. A further benefit of its small size, the MEMS relay is able to operate up to Ka-band (40 GHz) with hot switch capability and repeatability of <+/- 50mn Omega. To our knowledge, our latest SPDT device holds the current record in power handling for MEMS devices of 24 W at 10 million cycles. C1 [Cohn, Michael B.; Saechao, Kaosio; Whitlock, Michael; Brenman, Daniel; Tang, Wallace T.] MicroAssembly Technol Inc, 934 Marina Way South, Richmond, CA 94804 USA. [Proie, Robert M., Jr.] Army Res Lab, Adelphi, MD 20783 USA. RP Cohn, MB (reprint author), MicroAssembly Technol Inc, 934 Marina Way South, Richmond, CA 94804 USA. EM mbc@microassembly.com; ksc@microassembly.com; mwk@microassembly.com; dh@microassembly.com; wallacet@microassembly.com; robert.m.proie.civ@mail.mil FU U.S. Army [W911QX-07-C-0081]; U.S. Air Force [FA9453-07-D-0173]; STLE/ASME International Joint Tribology Conference, San Diego, CA [CD-ROM IJTC2007-44265] FX The switch and switch matrix development work has been supported by funding from the U.S. Army (Contract #: W911QX-07-C-0081) and U.S. Air Force (Contract #: FA9453-07-D-0173). Electrically steered antenna work has been supported by funding from the U.S. Army (Contract #: W911QX-07-C-0091) and U.S. Air Force (Contract #: FA8650-09-C-1600) STLE/ASME International Joint Tribology Conference, San Diego, CA, CD-ROM IJTC2007-44265 (2007). NR 4 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1089-3539 BN 978-1-4799-0859-2 J9 INT TEST CONF P PY 2013 PG 8 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BB1UQ UT WOS:000341376000014 ER PT J AU Jones, DE Hammond, P Platoni, K AF Jones, David E. Hammond, Patricia Platoni, Kathy TI Traumatic Event Management in Afghanistan: A Field Report on Combat Applications in Regional Command-South SO MILITARY MEDICINE LA English DT Editorial Material AB This article provides information on the use of Traumatic Event Management (TEM) strategies to debrief combat arms personnel whose units sustained traumatic losses in Afghanistan. The specific focus is on the application of Event-Driven Battlemind Psychological Debriefings to combat units. This article offers the first published account of TEM services employed in southern Afghanistan during intensive surge operations in 2009-2010. This article unfolds in three parts: (1) background to the region in which the debriefings occurred; (2) three case examples with a data summary of types of incidents observed; and (3) discussion of observations, lessons learned, and recommendations for training future clinicians to provide effective debriefings to combat arms personnel. C1 [Jones, David E.] Naval Med Ctr Portsmouth, Portsmouth, VA 23708 USA. [Hammond, Patricia] US Army, John F Kennedy Special Warfare Ctr & Sch, ATTN AOJK GRP, Stop Ft Bragg, NC 28310 USA. [Platoni, Kathy] Armed Forces Reserve Ctr, Madison, WI 53704 USA. RP Jones, DE (reprint author), Naval Med Ctr Portsmouth, 620 John Paul Jones Circle, Portsmouth, VA 23708 USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JAN PY 2013 VL 178 IS 1 BP 4 EP 10 DI 10.7205/MILMED-D-12-00070 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA AN7TV UT WOS:000340804800006 PM 23356111 ER PT J AU Walsh, R Heiner, J Kang, C Hile, D Deering, S AF Walsh, Ryan Heiner, Jason Kang, Christopher Hile, David Deering, Shad TI Emergency Physician Evaluation of a Novel Surgical Cricothyroidotomy Tool in Simulated Combat and Clinical Environments SO MILITARY MEDICINE LA English DT Article ID MEDICINE; MINIMUM; SKILLS AB We sought to investigate the performance of a novel cricothyroidotomy CRIC device compared to the traditional surgical in both simulated combat environments and the emergency department (ED) setting. Twenty U.S. Army staff and resident emergency medicine physicians were randomized to device and simulated setting order and performed cricothyroidotomies in the standard manner and with the CRIC device via the Trauma Man surgical simulator in three simulated settings: the ED, a day. combat environment, and a night combat environment. Differences in procedural completion for the two methods in different settings were compared by two-tailed paired t-tests. The occurrence of major and minor procedural complications and questions presented as 5-point Likert scales to describe participants' preferences of cricothyroidotomy methods were compared by chi(2) analysis. Time to incision, time to procedural completion, and rate of major and minor complications were not significantly different between the standard surgical method and the CRIC device (p > 0.05). In the simulated ED setting, 60% of participants preferred the standard surgical method (95% confidence interval: 38.5-81.5), whereas in the simulated combat settings, 50% of participants preferred each device (95% confidence interval: 28.1-71.9). In our population, we observed similar operator performance characteristics and physician preferences between the 2 methods in all simulated cricothyroidotomy settings. C1 [Walsh, Ryan; Kang, Christopher; Hile, David; Deering, Shad] Madigan Army Med Ctr, Tacoma, WA 98431 USA. [Heiner, Jason] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Heiner, Jason] Univ Washington, Div Emergency Med, Seattle, WA 98105 USA. RP Walsh, R (reprint author), Madigan Army Med Ctr, 9040 Fitzsimmons Dr, Tacoma, WA 98431 USA. NR 19 TC 1 Z9 1 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JAN PY 2013 VL 178 IS 1 BP 29 EP 33 DI 10.7205/MILMED-D-12-00266 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA AN7TV UT WOS:000340804800010 PM 23356115 ER PT J AU Westhoff, JL Roberts, BJ Erickson, K AF Westhoff, John L. Roberts, Brad J. Erickson, Kristin TI Vehicle-Mounted High-Power Microwave Systems and Health Risk Communication in a Deployed Environment SO MILITARY MEDICINE LA English DT Article AB Vehicle-mounted high-power microwave systems have been developed to counter the improvised explosive device threat in southwest Asia. Many service members only vaguely comprehend the nature of these devices and the nonionizing radio frequency (RF) radiation they emit. Misconceptions about the health effects of RIP radiation have the potential to produce unnecessary anxiety. We report an incident in which concern for exposure to radiation from a high-power microwave device thought to be malfunctioning led to an extensive field investigation, multiple evaluations by clinicians in theater, and subsequent referrals to an Occupational Health clinic upon return from deployment. When acute exposure to RF does occur, the effects are thermally mediated and immediately perceptible-limiting the possibility of injury. Unlike ionizing radiation, RF radiation is not known to cause cancer and the adverse health effects are not cumulative. Medical officers counseling service members concerned about potential RIP radiation exposure should apply established principles of risk communication, attend to real and perceived risks, and enlist the assistance of technical experts to properly characterize an exposure when appropriate. C1 [Westhoff, John L.; Erickson, Kristin] Madigan Healthcare Syst, Dept Prevent Med, Tacoma, WA 98431 USA. [Roberts, Brad J.] US Army, Publ Hlth Command, Army Inst Publ Hlth, Radio Frequency Program, Aberdeen Proving Ground, MD 21010 USA. RP Westhoff, JL (reprint author), Madigan Healthcare Syst, Dept Prevent Med, Bldg 9920-A East Johnson St, Tacoma, WA 98431 USA. NR 8 TC 0 Z9 2 U1 1 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JAN PY 2013 VL 178 IS 1 BP 34 EP 36 DI 10.7205/MILMED-D-12-00134 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA AN7TV UT WOS:000340804800011 PM 23356116 ER PT J AU Shrestha, M Combest, T Fonda, SJ Alfonso, A Guerrero, A AF Shrestha, Merica Combest, Travis Fonda, Stephanie J. Alfonso, Abel Guerrero, Arthur TI Effect of an Accelerometer on Body Weight and Fitness in Overweight and Obese Active Duty Soldiers SO MILITARY MEDICINE LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; PHYSICAL-ACTIVITY; LOSS INTERVENTIONS; PRIMARY-CARE; INTERNET; PROGRAM; ADULTS AB This study evaluated whether using a web-linked accelerometer, plus mandatory physical training, is associated with various weight- and fitness-related outcomes in overweight/obese active duty soldiers. Soldiers who failed the height/weight standards of the Army Physical Fitness Test (APFT) were randomized to use a Polar FA20 accelerometer device (polar accelerometer group [PA], n = 15) or usual care (UC, n = 13) for 6 months. Both groups received 1.5 hours of lifestyle instruction. We collected data at baseline, 2, 4, and 6 months, and evaluated group differences in temporal changes in study outcomes. At 6 months, 1/28 subjects (UC) passed the APFT height/weight standards. There were no group differences in changes in weight (PA: -0.1 kg vs. UC: +0.3 kg; p = 0.9), body fat (PA: -0.9% vs. UC: -1.1%; p = 0.9), systolic blood pressure (PA: +1.3 mm Hg vs. UC: -2.1 mm Hg; p = 0.2), diastolic blood pressure (PA: +3.8 mm Hg vs. UC: -2.4 mm Hg; p = 0.3), or resting heart rate in beats per minute (bpm) (PA: +7.8 bpm vs. UC: +0.1 bpm; p = 0.2). These results suggest that using an accelerometer with web-based feedback capabilities plus mandatory physical training does not assist in significant weight loss or ability to pass the APFT height/weight standards among overweight/obese soldiers. C1 [Shrestha, Merica] Walter Reed Natl Mil Med Ctr, Endocrinol Diabet & Metab Serv, Bethesda, MD 20889 USA. [Combest, Travis] Walter Reed Natl Mil Med Ctr, Bethesda, MD 20889 USA. [Fonda, Stephanie J.] Walter Reed Natl Mil Med Ctr, Inst Diabet, Bethesda, MD 20889 USA. [Alfonso, Abel] Mary Washington Healthcare, Endocrinol & Diabet Associates, Fredericksburg, VA 22401 USA. [Guerrero, Arthur] Tripler Army Med Ctr, Endocrinol Diabet & Metab Serv, Honolulu, HI 96859 USA. RP Shrestha, M (reprint author), Walter Reed Natl Mil Med Ctr, Endocrinol Diabet & Metab Serv, 8901 Rockville Pike, Bethesda, MD 20889 USA. FU Department of Clinical Investigations at the Walter Reed National Military Medical Center, Bethesda, Maryland FX Funding was provided by the Department of Clinical Investigations at the Walter Reed National Military Medical Center, Bethesda, Maryland. NR 17 TC 6 Z9 6 U1 1 U2 5 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JAN PY 2013 VL 178 IS 1 BP 82 EP 87 DI 10.7205/MILMED-D-12-00275 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA AN7TV UT WOS:000340804800019 PM 23356124 ER PT S AU Ovelgonne, M Park, N Subrahmanian, VS Bowman, EK Ogaard, KA AF Ovelgoenne, Michael Park, Noseong Subrahmanian, V. S. Bowman, Elizabeth K. Ogaard, Kirk A. BE Alani, H Kagal, L Fokoue, A Groth, P Biemann, C Parreira, JX Aroyo, L Noy, N Welty, C Janowicz, K TI Personalized Best Answer Computation in Graph Databases SO SEMANTIC WEB - ISWC 2013, PART I SE Lecture Notes in Computer Science LA English DT Proceedings Paper CT 12th International Semantic Web Conference (ISWC) CY OCT 21-25, 2013 CL Sydney, AUSTRALIA SP Bing, Fluid Operat, Microsoft Res, PreviousNext, IBM Res, Ontotext, Yahoo, IOS Press, OpenLink Software ID ALGORITHM; ISOMORPHISM AB Though subgraph matching has been extensively studied as a query paradigm in semantic web and social network data environments, a user can get a large number of answers in response to a query. Just like Google does, these answers can be shown to the user in accordance with an importance ranking. In this paper, we present scalable algorithms to find the top-K answers to a practically important subset of SPARQL-queries, denoted as importance queries, via a suite of pruning techniques. We test our algorithms on multiple real-world graph data sets, showing that our algorithms are efficient even on networks with up to 6M vertices and 15M edges and far more efficient than popular triple stores. C1 [Ovelgoenne, Michael; Subrahmanian, V. S.] Univ Maryland, UMIACS, College Pk, MD 20742 USA. [Park, Noseong; Subrahmanian, V. S.] Univ Maryland, Dept Comp Sci, College Pk, MD 20742 USA. [Bowman, Elizabeth K.; Ogaard, Kirk A.] US Army Res Lab, Tact Informat Fus Branch, Computat & Informat Sci, Aberdeen Proving Ground, MD USA. RP Ovelgonne, M (reprint author), Univ Maryland, UMIACS, College Pk, MD 20742 USA. EM mov@umiacs.umd.edu; npark@umiacs.umd.edu; vs@umiacs.umd.edu; elizabeth.k.bowman.civ@mail.mil; kirk.a.ogaard.ctr@mail.mil FU US Army Research Office [W911NF0910206] FX We thank the anonymous reviewers and Barry Bishop and Nikolay Krustev from Ontotext for their helpful remarks. Parts of this work have been funded by the US Army Research Office under grantW911NF0910206. NR 15 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0302-9743 BN 978-3-642-41335-3; 978-3-642-41334-6 J9 LECT NOTES COMPUT SC PY 2013 VL 8218 BP 478 EP 493 PG 16 WC Computer Science, Information Systems; Computer Science, Theory & Methods SC Computer Science GA BB0MD UT WOS:000340417700030 ER PT S AU West, BJ AF West, Bruce J. BA West, BJ BF West, BJ TI FRACTAL PHYSIOLOGY AND CHAOS IN MEDICINE 2nd Edition Introduction SO FRACTAL PHYSIOLOGY AND CHAOS IN MEDICINE, 2ND EDITION SE Studies of Nonlinear Phenomena in Life Science LA English DT Editorial Material; Book Chapter C1 Army Res Off, Ft Bragg, NC 28306 USA. RP West, BJ (reprint author), Army Res Off, Ft Bragg, NC 28306 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE SN 1793-1428 BN 978-981-4417-80-8; 978-981-4417-79-2 J9 STUD NONLIN PHENOM PY 2013 VL 16 BP 1 EP 25 D2 10.1142/8577 PG 25 WC Biology; Mathematics, Interdisciplinary Applications; Medicine, Research & Experimental SC Life Sciences & Biomedicine - Other Topics; Mathematics; Research & Experimental Medicine GA BA7HA UT WOS:000337525800002 ER PT S AU West, BJ AF West, Bruce J. BA West, BJ BF West, BJ TI FRACTAL PHYSIOLOGY AND CHAOS IN MEDICINE 2nd Edition Preface SO FRACTAL PHYSIOLOGY AND CHAOS IN MEDICINE, 2ND EDITION SE Studies of Nonlinear Phenomena in Life Science LA English DT Editorial Material; Book Chapter C1 Army Res Off, Ft Bragg, NC 28306 USA. RP West, BJ (reprint author), Army Res Off, Ft Bragg, NC 28306 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE SN 1793-1428 BN 978-981-4417-80-8; 978-981-4417-79-2 J9 STUD NONLIN PHENOM PY 2013 VL 16 BP IX EP + D2 10.1142/8577 PG 34 WC Biology; Mathematics, Interdisciplinary Applications; Medicine, Research & Experimental SC Life Sciences & Biomedicine - Other Topics; Mathematics; Research & Experimental Medicine GA BA7HA UT WOS:000337525800001 ER PT S AU West, BJ AF West, Bruce J. BA West, BJ BF West, BJ TI Physiology in Fractal Dimensions SO FRACTAL PHYSIOLOGY AND CHAOS IN MEDICINE, 2ND EDITION SE Studies of Nonlinear Phenomena in Life Science LA English DT Article; Book Chapter C1 Army Res Off, Ft Bragg, NC 28306 USA. RP West, BJ (reprint author), Army Res Off, Ft Bragg, NC 28306 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE SN 1793-1428 BN 978-981-4417-80-8; 978-981-4417-79-2 J9 STUD NONLIN PHENOM PY 2013 VL 16 BP 27 EP 91 D2 10.1142/8577 PG 65 WC Biology; Mathematics, Interdisciplinary Applications; Medicine, Research & Experimental SC Life Sciences & Biomedicine - Other Topics; Mathematics; Research & Experimental Medicine GA BA7HA UT WOS:000337525800003 ER PT S AU West, BJ AF West, Bruce J. BA West, BJ BF West, BJ TI Dynamics in Fractal Dimensions SO FRACTAL PHYSIOLOGY AND CHAOS IN MEDICINE, 2ND EDITION SE Studies of Nonlinear Phenomena in Life Science LA English DT Article; Book Chapter C1 Army Res Off, Ft Bragg, NC 28306 USA. RP West, BJ (reprint author), Army Res Off, Ft Bragg, NC 28306 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE SN 1793-1428 BN 978-981-4417-80-8; 978-981-4417-79-2 J9 STUD NONLIN PHENOM PY 2013 VL 16 BP 93 EP 176 D2 10.1142/8577 PG 84 WC Biology; Mathematics, Interdisciplinary Applications; Medicine, Research & Experimental SC Life Sciences & Biomedicine - Other Topics; Mathematics; Research & Experimental Medicine GA BA7HA UT WOS:000337525800004 ER PT S AU West, BJ AF West, Bruce J. BA West, BJ BF West, BJ TI Statistics in Fractal Dimensions SO FRACTAL PHYSIOLOGY AND CHAOS IN MEDICINE, 2ND EDITION SE Studies of Nonlinear Phenomena in Life Science LA English DT Article; Book Chapter C1 Army Res Off, Ft Bragg, NC 28306 USA. RP West, BJ (reprint author), Army Res Off, Ft Bragg, NC 28306 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE SN 1793-1428 BN 978-981-4417-80-8; 978-981-4417-79-2 J9 STUD NONLIN PHENOM PY 2013 VL 16 BP 177 EP 209 D2 10.1142/8577 PG 33 WC Biology; Mathematics, Interdisciplinary Applications; Medicine, Research & Experimental SC Life Sciences & Biomedicine - Other Topics; Mathematics; Research & Experimental Medicine GA BA7HA UT WOS:000337525800005 ER PT S AU West, BJ AF West, Bruce J. BA West, BJ BF West, BJ TI Applications of Chaotic Attractors SO FRACTAL PHYSIOLOGY AND CHAOS IN MEDICINE, 2ND EDITION SE Studies of Nonlinear Phenomena in Life Science LA English DT Article; Book Chapter C1 Army Res Off, Ft Bragg, NC 28306 USA. RP West, BJ (reprint author), Army Res Off, Ft Bragg, NC 28306 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE SN 1793-1428 BN 978-981-4417-80-8; 978-981-4417-79-2 J9 STUD NONLIN PHENOM PY 2013 VL 16 BP 211 EP 260 D2 10.1142/8577 PG 50 WC Biology; Mathematics, Interdisciplinary Applications; Medicine, Research & Experimental SC Life Sciences & Biomedicine - Other Topics; Mathematics; Research & Experimental Medicine GA BA7HA UT WOS:000337525800006 ER PT S AU West, BJ AF West, Bruce J. BA West, BJ BF West, BJ TI Physiological Networks: The Final Chapter? SO FRACTAL PHYSIOLOGY AND CHAOS IN MEDICINE, 2ND EDITION SE Studies of Nonlinear Phenomena in Life Science LA English DT Article; Book Chapter C1 Army Res Off, Ft Bragg, NC 28306 USA. RP West, BJ (reprint author), Army Res Off, Ft Bragg, NC 28306 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE SN 1793-1428 BN 978-981-4417-80-8; 978-981-4417-79-2 J9 STUD NONLIN PHENOM PY 2013 VL 16 BP 261 EP 280 D2 10.1142/8577 PG 20 WC Biology; Mathematics, Interdisciplinary Applications; Medicine, Research & Experimental SC Life Sciences & Biomedicine - Other Topics; Mathematics; Research & Experimental Medicine GA BA7HA UT WOS:000337525800007 ER PT J AU Shiflett, SA Zinnert, JC Young, DR AF Shiflett, Sheri A. Zinnert, Julie C. Young, Donald R. TI Changes in plant community composition and structure following restoration of maritime communities SO JOURNAL OF THE TORREY BOTANICAL SOCIETY LA English DT Article DE community; functional groups; maritime communities; ordination; restoration; structure ID SEED BANK; SPONTANEOUS SUCCESSION; SECONDARY SUCCESSION; OLD-FIELDS; VEGETATION; DYNAMICS; FOREST; DIVERSITY; VIRGINIA; ISLAND AB SHIFLETT, S. A. (Department of Biology, Virginia Commonwealth University, Richmond, VA 23284), J. C. ZINNERT (US Army ERDC Fluorescence Spectroscopy Lab, Alexandria, VA 22315), AND D. R. YOUNG (Department of Biology, Virginia Commonwealth University, Richmond, VA 23284). Changes in plant community composition and structure following restoration of maritime communities. J. Torrey Bot. Soc. 140: 89-100. 2013.-Old field succession has been reviewed extensively in many community settings; however, secondary succession in maritime communities, especially forest and shrub communities is poorly understood. Maritime communities of the North American Atlantic coast are unique and often fragmented ecosystems that provide critical stopover sites for migratory birds. Historical losses coupled with rising developmental pressures have created the need for conservation and restoration to protect these globally rare communities. We examined secondary succession by analyzing the vegetation community composition and soil seed bank of an abandoned agricultural field initially and at seven years (2009) after initiation of state-agency site restoration that used a combination of active and passive restoration techniques. The restoration field was divided into three projected habitats: early maritime forest (16 ha), maritime shrub (12 ha), and coastal grassland (8 ha). A trend was observed with loss of species richness across habitat types. There was a high proportion of species turnover, yet there were no significant differences in the number of species belonging to functional groups for each habitat between the two sampling years (2003 and 2009). Zones where active restoration techniques were used were more indicative of restoration success compared to areas that relied on spontaneous succession. Long-term vegetation surveys are critical to assess the success of restoration operations, and to describe and predict successional trajectories. Accessible vegetation survey data may become increasingly important in the future as land managers place more emphasis on protecting and restoring these overdeveloped, unique coastal communities. C1 [Shiflett, Sheri A.; Young, Donald R.] Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA. [Zinnert, Julie C.] US Army ERDC Fluorescence Spect Lab, Alexandria, VA 22315 USA. RP Zinnert, JC (reprint author), US Army ERDC Fluorescence Spect Lab, Alexandria, VA 22315 USA. EM jczinner@vcu.edu FU Adkins Arboretum grant FX This work was supported partially by an Adkins Arboretum grant to JCZ. NR 49 TC 1 Z9 1 U1 5 U2 21 PU TORREY BOTANICAL SOC PI LAWRENCE PA 810 E 10TH ST, LAWRENCE, KS 66044 USA SN 1095-5674 EI 1940-0616 J9 J TORREY BOT SOC JI J. Torrey Bot. Soc. PD JAN PY 2013 VL 140 IS 1 BP 89 EP 100 DI 10.3159/TORREY-D-12-00008.1 PG 12 WC Plant Sciences SC Plant Sciences GA AM2BY UT WOS:000339654800009 ER PT J AU Vincent, DS Berg, BW AF Vincent, Dale S. Berg, Benjamin W. BE Arora, R Arora, P TI Manikin Simulation for Mass Casualty Incident Training SO DISASTER MANAGEMENT: MEDICAL PREPAREDNESS, RESPONSE AND HOMELAND SECURITY LA English DT Article; Book Chapter ID CHEMICAL WARFARE CASUALTIES; PUBLIC-HEALTH PREPAREDNESS; FLORIDA TRAUMA TRIAGE; MEDICAL-EDUCATION; DISASTER MEDICINE; SKILLS; CARE; TECHNOLOGY; BOMBINGS; CRITERIA C1 [Vincent, Dale S.] Tripler Army Med Ctr, Dept Med, MCHK DM, Internal Med Residency Program, Honolulu, HI 96859 USA. [Berg, Benjamin W.] John A Burns Sch Med, SimTiki Simulat Ctr, Honolulu, HI 96813 USA. RP Vincent, DS (reprint author), Tripler Army Med Ctr, Dept Med, MCHK DM, Internal Med Residency Program, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 51 TC 0 Z9 0 U1 0 U2 0 PU CABI PUBLISHING-C A B INT PI WALLINGFORD PA CABI PUBLISHING, WALLINGFORD 0X10 8DE, OXON, ENGLAND BN 978-1-84593-929-8 PY 2013 BP 50 EP 64 D2 10.1079/9781845939298.0000 PG 15 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA BA3QN UT WOS:000334643900004 ER PT S AU Borodin, O Jow, TR AF Borodin, Oleg Jow, T. Richard BE Smart, MC Inaba, M Fenton, J Henderson, W Ue, M Doughty, DH Jow, TR Ishikawa, M Bugga, RV Tatsumi, K Lucht, B Trulove, PC TI Quantum Chemistry Study of the Oxidation-Induced Decomposition of Tetramethylene Sulfone (TMS) Dimer and TMS/BF4- SO LITHIUM-ION BATTERIES -AND- NON-AQUEOUS ELECTROLYTES FOR LITHIUM BATTERIES - PRIME 2012 SE ECS Transactions LA English DT Proceedings Paper CT Symposia on Lithium-Ion Batteries and Non-Aqueous Electrolytes for Lithium Batteries CY OCT 07-12, 2012 CL Honolulu, HI SP Electrochem Soc, Electrochem Soc Japan, Japan Soc Appl Phys, Korean Electrochem Soc, Royal Australian Chem Inst, Electrochemistry Div, Chinese Soc Electrochemistry, Battery Div, Energy Technol Div, Phys & Analyt Electrochemistry Div ID LI-ION BATTERIES; DENSITY-FUNCTIONAL THEORY; NONCOVALENT INTERACTIONS; ELECTROCHEMICAL WINDOWS; PROPYLENE CARBONATE; LITHIUM BATTERIES; ELECTROLYTES; POTENTIALS; ANIONS; STABILITY AB The oxidation-induced decomposition reactions of tetramethylene sulfone (TMS), its dimer and a TMS/BF4- complex were studied using M05-2X and LC-omega PBE density functionals in conjunction with a polarized continuum model (PCM). The presence of an anion or another TMS molecule near a TMS molecule was found to dramatically reduce the barriers for the initial step of the oxidation decomposition reactions of TMS and changed the order of the oxidation reactions and products. Specifically, the barrier for the H-abstraction reaction of TMS was reduced from 0.9-1.0 eV for isolated TMS to 0.1-0.2 eV in the TMS dimer. The presence of BF4- near TMS also reduced the barriers for both the TMS ring opening and the H-abstraction reactions. The most kinetically active reactions were (a) the TMS ring opening with a fluorine transfer from BF4- to the open TMS ring in the TMS/BF4- complex and (b) the intramolecular H-transfer from a methylene group to the sulfone oxygen in a TMS dimer. In the oxidized TMS2, the H-transfer reaction was assisted by the SO2-group from the neighboring TMS molecule. The ability of the M05-2X and LC-omega PBE density functionals to accurately describe TMS oxidation reactions was benchmarked through a comparison with the composite G4MP2 theory. C1 [Borodin, Oleg; Jow, T. Richard] US Army Res Lab, Electrochem Branch, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Borodin, O (reprint author), US Army Res Lab, Electrochem Branch, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RI Borodin, Oleg/B-6855-2012 OI Borodin, Oleg/0000-0002-9428-5291 NR 37 TC 4 Z9 4 U1 0 U2 10 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA SN 1938-5862 BN 978-1-60768-414-5 J9 ECS TRANSACTIONS PY 2013 VL 50 IS 26 BP 391 EP 398 DI 10.1149/05026.0391ecst PG 8 WC Electrochemistry; Energy & Fuels SC Electrochemistry; Energy & Fuels GA BA8VT UT WOS:000338893200035 ER PT S AU Ho, J Jow, TR AF Ho, Janet Jow, T. Richard GP IEEE TI Effect of Crystallinity and Morphology on Dielectric Properties of PEEK at Elevated Temperature SO PROCEEDINGS OF THE 2013 IEEE INTERNATIONAL CONFERENCE ON SOLID DIELECTRICS (ICSD 2013), VOLS 1 AND 2 SE IEEE International Conference on Solid Dielectrics-ICSD LA English DT Proceedings Paper CT 11th IEEE International Conference on Solid Dielectrics (ICSD) CY JUN 30-JUL 04, 2013 CL Bologna, ITALY SP IEEE, IEEE Dielectr & Elect Insulat Soc, Univ Bologna, Dept Elect, Elect & Informat Engn, Lab Innovat Technol, Dow Inside, TECHMP DE Poly(aryl ether ether ketone) (PEEK); high temperature polymer; electrical conductivity; breakdown strength; crystallinity ID POLY(ETHER ETHER KETONE); ELECTRICAL-CONDUCTION; POLYPROPYLENE; POLYETHYLENE; BREAKDOWN; STRENGTH; BEHAVIOR; FILMS AB Poly(aryl ether ether ketone) (PEEK) is one of the primary candidates for a high temperature capacitor dielectric as a result of its outstanding mechanical strength and thermal stability. However, its breakdown strength is unsatisfactory (similar to 400 MV/m) and high field (>100 MV/m) volumetric resistivity at elevated temperature is largely unknown. In this work, the inter-relationship among crystallinity, morphology, breakdown strength, and volumetric resistivity of PEEK at elevated temperature is studied in order to gain insight to factors which adversely affect breakdown. This paper presents preliminary results of the study. C1 [Ho, Janet; Jow, T. Richard] US Army Res Lab, Adelphi, MD 20783 USA. RP Ho, J (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. NR 17 TC 2 Z9 2 U1 2 U2 11 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1553-5282 BN 978-1-4673-4461-6 J9 IEEE INT C SOL DIEL PY 2013 BP 385 EP 388 PG 4 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary SC Engineering; Materials Science GA BA9BL UT WOS:000339117400088 ER PT S AU Grew, KN Chu, D AF Grew, Kyle. N. Chu, Deryn BE Wu, N Dinh, H Lee, JJ Subramanian, R Zou, Z Chiu, W Domen, K Manivannan, A Wang, H Chu, D Kulesza, PJ Narayan, SR Zhou, XD TI Transport Phenomena in Bi-Cells for Portable Fuel Cell Power Sources SO RENEWABLE FUELS FROM SUNLIGHT AND ELECTRICITY SE ECS Transactions LA English DT Proceedings Paper CT Symposium on Renewable Fuels from Sunlight and Elect held during the PRiME Joint Int Meeting of the Electrochemical-Soc and the Electrochemical-Soc-of-Japan CY OCT 07-12, 2012 CL Honolulu, HI SP Electrochem Soc, Electrochem Soc Japan, Japan Soc Appl Phys, Korean Electrochem Soc, Royal Australian Chem Inst, Electrochemistry Div, Chinese Soc Electrochemistry, Energy Technol Div, High Temp Mat Div, Phys & Analyt Electrochemistry Div, New Technol Subcommittee Div ID WATER CROSSOVER; DMFC SYSTEM; PERFORMANCE; CHALLENGE; MEDIA AB The specific energy of neat liquid methanol tends to provide direct methanol fuel cell (DMFC) systems with large energy densities, making them ideal for portable power applications. However, portable DMFC systems are larger than desired. The balance of plant (BOP) is the key contributor to the system volume, and specifically components used for water management. In this study, a theoretical approach is taken to better understand the water management requirements. A passive bi-cell, or pseudo bipolar, configuration is used as a baseline for this study. C1 [Grew, Kyle. N.; Chu, Deryn] US Army Res Lab, Adelphi, MD 20910 USA. RP Grew, KN (reprint author), US Army Res Lab, Adelphi, MD 20910 USA. NR 8 TC 0 Z9 0 U1 0 U2 2 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA SN 1938-5862 BN 978-1-60768-437-4 J9 ECS TRANSACTIONS PY 2013 VL 50 IS 49 BP 103 EP 112 DI 10.1149/05049.0103ecst PG 10 WC Electrochemistry; Energy & Fuels; Physics, Applied SC Electrochemistry; Energy & Fuels; Physics GA BA8VU UT WOS:000338897800012 ER PT S AU Mercado, RML Fury, J Kiely, MB Buhrmaster, D Miller, CE Zarras, P AF Mercado, R. M. L. Fury, J. Kiely, M. B. Buhrmaster, D. Miller, C. E. Zarras, P. BE UrquidiMacdonald, M Taylor, CD Haruna, T TI Investigation of Zinc Dimercaptothiadiazole as a Corrosion Inhibitor for Steel SO CORROSION, PASSIVITY, AND ENERGY: A SYMPOSIUM IN HONOR OF DIGBY D. MACDONALD SE ECS Transactions LA English DT Proceedings Paper CT ECS 3D Symposium on Corrosion, Passivity, and Energy - In Honor of Digby D. Macdonald CY OCT 07-12, 2012 CL Honolulu, HI SP ECS, Corros Div ID 2,5-DIMERCAPTO-1,3,4-THIADIAZOLE; ELECTRODEPOSITION; FILMS AB The mechanism of corrosion inhibition of zinc dithiomercaptothiadiazole (Zn(DMcT)(2)) has been known and elucidated. The efficacy of (Zn(DMcT)(2)) as used in primer coatings for corrosion inhibition on steel alloys such as 1010 steel and 4130 high strength steel under neutral pH conditions was investigated by accelerated corrosion testing methodologies. Solution-state studies and surface elemental analyses were conducted to determine the possible mechanism of corrosion inhibition. Solution state experiments showed a correlation between increasing Zn(DMcT)(2) amounts and increased polarization resistance, but DMcT on its own did not show this relationship. Under neutral pH conditions, it was determined that Zn(II) species such as Zn(OH)(2), Zn(DMcT)(2), and possibly ZnO were deposited on the steel surface, providing corrosion protection. C1 [Mercado, R. M. L.; Fury, J.; Kiely, M. B.] Crosslink, 950 Bolger Ct, St Louis, MO 63026 USA. [Buhrmaster, D.] Univ Dayton, Res Inst, Dayton, OH 45469 USA. [Miller, C. E.] US Army, Res Lab, RDL WMM C, Aberdeen Proving Ground, MD 21005 USA. [Zarras, P.] NAWCWD, China Lake, CA 93555 USA. RP Mercado, RML (reprint author), Crosslink, 950 Bolger Ct, St Louis, MO 63026 USA. NR 13 TC 0 Z9 0 U1 0 U2 1 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA SN 1938-5862 BN 978-1-60768-419-0 J9 ECS TRANSACTIONS PY 2013 VL 50 IS 31 BP 345 EP 354 DI 10.1149/05031.0345ecst PG 10 WC Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Electrochemistry; Energy & Fuels; Materials Science GA BA8FF UT WOS:000338035300028 ER PT S AU Chung, K Rozumov, E Kaminsky, D Buescher, T Manship, T Valdivia, A Cook, P Anderson, P AF Chung, K. Rozumov, E. Kaminsky, D. Buescher, T. Manship, T. Valdivia, A. Cook, P. Anderson, P. BE PodlahaMurphy, EJ Kanamura, K Munakata, H Fenton, JM TI Development of Electrically Controlled Energetic Materials SO EMERGING MATERIALS AND PROCESSES FOR ENERGY CONVERSION AND STORAG E SE ECS Transactions LA English DT Proceedings Paper CT Symposium on Emerging Mat and Proc for Energy Convers and Storage held during the PRiME Joint Int Meeting of the Electrochem-Soc and the Electrochem-Soc-of-Japan CY OCT 07-12, 2012 CL Honolulu, HI SP Electrochem Soc, Electrochem Soc Japan, Japan Soc Appl Phys, Korean Electrochem Soc, Royal Australian Chem Inst, Electrochemistry Div, Chinese Soc Electrochemistry, Electrodeposit Div, Battery Div, Energy Technol Div AB U.S. Army ARDEC has been examining a novel pyroelectric-type material developed by Digital Solid State Propulsion, LLC for its unique combustion properties and insensitivity. This unique ECEM is formed using an ionic liquid oxidizer and polymer fuel, via sol-gel processes and is quite dense, making it very suitable for energetic applications in both the civilian and military fields. This ECEM is completely insensitive to the application of impact, flame, friction, and shock threats. Once a power of the required voltage is applied, the baseline ECEM rapidly initiates combustion with H2O, CO2, and N-2 formed as the only major gas phase products produced. Initial testing of ECEM in perforated pipes appears promising as indicated by uniform ignition along the entire length of the test assembly. C1 [Chung, K.; Rozumov, E.; Kaminsky, D.; Cook, P.; Anderson, P.] US Army ARDEC, Picatinny Arsenal, NJ 07806 USA. [Buescher, T.; Manship, T.; Valdivia, A.] LLC Reno, Reno, NV 89511 USA. RP Chung, K (reprint author), US Army ARDEC, Picatinny Arsenal, NJ 07806 USA. FU U.S. Army ARDEC's Science FX This work has been supported from funding under the U.S. Army ARDECs Science and Technology program. NR 3 TC 0 Z9 0 U1 0 U2 3 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA SN 1938-5862 BN 978-1-60768-428-2 J9 ECS TRANSACTIONS PY 2013 VL 50 IS 40 BP 59 EP 66 DI 10.1149/05040.0059ecst PG 8 WC Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary; Physics, Applied SC Electrochemistry; Energy & Fuels; Materials Science; Physics GA BA8HV UT WOS:000338124800007 ER PT S AU Carpin, S Chung, TH Sadler, BM AF Carpin, Stefano Chung, Timothy H. Sadler, Brian M. GP IEEE TI Theoretical Foundations of High-Speed Robot Team Deployment SO 2013 IEEE INTERNATIONAL CONFERENCE ON ROBOTICS AND AUTOMATION (ICRA) SE IEEE International Conference on Robotics and Automation ICRA LA English DT Proceedings Paper CT IEEE International Conference on Robotics and Automation (ICRA) CY MAY 06-10, 2013 CL Karlsruhe, GERMANY SP IEEE AB In this paper we study the multi-robot deployment problem under hard temporal constraints. After proposing a model for this task, we consider the simplest deployment algorithm and we analyze the relationship between three fundamental parameters, the temporal deadline, the probability of success, and the number of robots. Because an exact analysis of even the simplest algorithm is computationally intractable, we derive an approximate bound leading to performance curves useful to answer design questions (how many robots are needed to get a certain performance guarantee?) or analysis questions (what is the probability of success given a certain deadline and number of robots?) Simulations show that the bounds are sharp and provide a useful tool to predict team deployment performance and tradeoffs. C1 [Carpin, Stefano] Univ Calif, Sch Engn, Merced, CA 95343 USA. [Chung, Timothy H.] Naval Postgrade Sch, Monterey, CA USA. [Sadler, Brian M.] Army Res Lab, Adelphi, MD USA. RP Carpin, S (reprint author), Univ Calif, Sch Engn, Merced, CA 95343 USA. EM scarpin@ucmerced.edu; thchung@nps.edu; brian.m.sadler6.civ@mail.mil NR 9 TC 2 Z9 2 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1050-4729 BN 978-1-4673-5641-1; 978-1-4673-5643-5 J9 IEEE INT CONF ROBOT PY 2013 BP 2033 EP 2040 PG 8 WC Automation & Control Systems; Engineering, Electrical & Electronic; Robotics SC Automation & Control Systems; Engineering; Robotics GA BA7KQ UT WOS:000337617302007 ER PT S AU Rogers, JG Christensen, HI AF Rogers, John G., III Christensen, Henrik I. GP IEEE TI Robot Planning with a Semantic Map SO 2013 IEEE INTERNATIONAL CONFERENCE ON ROBOTICS AND AUTOMATION (ICRA) SE IEEE International Conference on Robotics and Automation ICRA LA English DT Proceedings Paper CT IEEE International Conference on Robotics and Automation (ICRA) CY MAY 06-10, 2013 CL Karlsruhe, GERMANY SP IEEE AB Context is an important factor for domestic service robots to consider when interpreting their environments to perform tasks. In people's homes, rooms are laid out in a specific arrangement to enable comfortable and efficient living; for example, the living room is central to the house, and the dining room is adjacent to the kitchen. The identity of the objects in a room are a strong cue for determining that room's purpose. This paper will present a planner for an autonomous mobile robot system which uses room connectivity topology and object understanding as context for an object search task in a domestic environment. C1 [Rogers, John G., III] Army Res Lab, Adelphi, MD 20783 USA. [Rogers, John G., III; Christensen, Henrik I.] Georgia Inst Technol, Coll Comp, Atlanta, GA 30332 USA. RP Rogers, JG (reprint author), Army Res Lab, Adelphi, MD 20783 USA. EM jgrogers@gmail.com; hic@cc.gatech.edu FU ARL MAST CTA FX This work was made possible through the ARL MAST CTA project. The authors would also like to thank Carlos Nieto for his assistance in performing the experiments NR 18 TC 2 Z9 3 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1050-4729 BN 978-1-4673-5641-1; 978-1-4673-5643-5 J9 IEEE INT CONF ROBOT PY 2013 BP 2239 EP 2244 PG 6 WC Automation & Control Systems; Engineering, Electrical & Electronic; Robotics SC Automation & Control Systems; Engineering; Robotics GA BA7KQ UT WOS:000337617302037 ER PT S AU Delmerico, JA Baran, D David, P Ryde, J Corso, JJ AF Delmerico, Jeffrey A. Baran, David David, Philip Ryde, Julian Corso, Jason J. GP IEEE TI Ascending Stairway Modeling from Dense Depth Imagery for Traversability Analysis SO 2013 IEEE INTERNATIONAL CONFERENCE ON ROBOTICS AND AUTOMATION (ICRA) SE IEEE International Conference on Robotics and Automation ICRA LA English DT Proceedings Paper CT IEEE International Conference on Robotics and Automation (ICRA) CY MAY 06-10, 2013 CL Karlsruhe, GERMANY SP IEEE ID VISION AB Localization and modeling of stairways by mobile robots can enable multi-floor exploration for those platforms capable of stair traversal. Existing approaches focus on either stairway detection or traversal, but do not address these problems in the context of path planning for the autonomous exploration of multi-floor buildings. We propose a system for detecting and modeling ascending stairways while performing simultaneous localization and mapping, such that the traversability of each stairway can be assessed by estimating its physical properties. The long-term objective of our approach is to enable exploration of multiple floors of a building by allowing stairways to be considered during path planning as traversable portals to new frontiers. We design a generative model of a stairway as a single object. We localize these models with respect to the map, and estimate the dimensions of the stairway as a whole, as well as its steps. With these estimates, a robot can determine if the stairway is traversable based on its climbing capabilities. Our system consists of two parts: a computationally efficient detector that leverages geometric cues from dense depth imagery to detect sets of ascending stairs, and a stairway modeler that uses multiple detections to infer the location and parameters of a stairway that is discovered during exploration. We demonstrate the performance of this system when deployed on several mobile platforms using a Microsoft Kinect sensor. C1 [Delmerico, Jeffrey A.; Ryde, Julian; Corso, Jason J.] SUNY Buffalo, Buffalo, NY 14260 USA. [Baran, David; David, Philip] US Army Res Lab, Buffalo, NY 14260 USA. RP Delmerico, JA (reprint author), SUNY Buffalo, Buffalo, NY 14260 USA. EM jad12@buffalo.edu; david.g.baran.civ@mail.mil; philip.j.david4.civ@mail.mil; jryde@buffalo.edu; jcorso@buffalo.edu FU Federal Highway Administration [DTFH61-07-H-00023]; Army Research Office [W911NF-ll-I-0090]; National Science Foundation CAREER [IIS-0845282] FX This material is based upon work partially supported by the Federal Highway Administration under Cooperative Agreement No. DTFH61-07-H-00023, the Army Research Office (W911NF- ll-I-0090) and the National Science Foundation CAREER grant (IIS-0845282). Any opinions, findings, conclusions or recommendations are those of the authors and do not necessarily reflect the views of the FHWA, ARO, or NSF NR 21 TC 10 Z9 10 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1050-4729 BN 978-1-4673-5641-1; 978-1-4673-5643-5 J9 IEEE INT CONF ROBOT PY 2013 BP 2283 EP 2290 PG 8 WC Automation & Control Systems; Engineering, Electrical & Electronic; Robotics SC Automation & Control Systems; Engineering; Robotics GA BA7KQ UT WOS:000337617302044 ER PT J AU Bakhtyar, R Razmi, AM Barry, DA Kees, CE Yeganeh-Bakhtiary, A Miller, CT AF Bakhtyar, R. Razmi, A. M. Barry, D. A. Kees, C. E. Yeganeh-Bakhtiary, A. Miller, C. T. TI Two-phase flow modeling of the influence of wave shapes and bed slope on nearshore hydrodynamics SO JOURNAL OF COASTAL RESEARCH LA English DT Article; Proceedings Paper CT 12th International Coastal Symposium (ICS) CY APR 09-12, 2013 CL Plymouth Univ, Sch Marine Sci & Engn, Coastal Proc Res Grp, Plymouth, ENGLAND HO Plymouth Univ, Sch Marine Sci & Engn, Coastal Proc Res Grp DE Multi-phase flow; hydrodynamics; plunging breakers; spilling breakers; TKE; wave types ID SWASH-ZONE; BREAKING WAVES; NUMERICAL-SIMULATION; SURF ZONE; SEDIMENT TRANSPORT; SHEET FLOW; BEACH; TURBULENCE; DYNAMICS AB An Eulerian two-phase flow model (air-water) was used to simulate nearshore hydrodynamic processes driven by wave motion. The flow field was computed with the Reynolds-Averaged Navier-Stokes equations in conjunction with the Volume-Of-Fluid method and the RNG turbulence-closure scheme. To study the effects of different wave shapes on surf-swash zone hydrodynamics, a set of numerical experiments was carried out. Predictions of three wave theories (Airy, 2nd-order Stokes and 5th-order Stokes) were compared, with a focus on the turbulence and flow fields. Model performance was assessed by comparing numerical results with laboratory experimental observations. Relationships between the water depth, undertow, TKE and wave characteristics are presented. The results indicate that the characteristics of turbulence and flow, for example the position of wave breaking and magnitude of TKE, are affected by different wave types. Numerical simulations showed that only high-order Stokes wave theory predicts the nonlinearity required for predicting hydrodynamic characteristics in agreement with existing understanding of nearshore processes. Numerical simulations were run for different hydrodynamic conditions, but with a focus on different bed slopes. The transformation of incoming waves as they reach shallow water occurs closer to the shoreline for steeper profiles. Consistently, the peaks in TKE and wave set-up are shifted onshore for steeper slopes. The numerical results showed that TKE and undertow velocity are smaller on dissipative beaches than on intermediate beaches. C1 [Bakhtyar, R.; Miller, C. T.] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27514 USA. [Bakhtyar, R.; Kees, C. E.] US Army, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. [Bakhtyar, R.; Razmi, A. M.; Barry, D. A.] Ecole Polytech Fed Lausanne, Fac Environm Nat Architectural & Construit ENAC, CH-1015 Lausanne, Switzerland. [Yeganeh-Bakhtiary, A.] Cardiff Univ, Sch Engn, Hydroenvironm Res Ctr, Cardiff CF10 3AX, S Glam, Wales. RP Bakhtyar, R (reprint author), Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27514 USA. EM roham.bakhtyar@unc.edu; amir.razmi@epfl.ch; andrew.barry@epfl.ch; chris.kees@us.army.mil; yeganeh@cardiff.ac.uk; casey_miller@unc.edu RI Barry, David/C-6077-2008; Miller, Cass T./I-6613-2012 OI Barry, David/0000-0002-8621-0425; Miller, Cass T./0000-0001-6082-9273 NR 31 TC 5 Z9 5 U1 2 U2 11 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 EI 1551-5036 J9 J COASTAL RES JI J. Coast. Res. PY 2013 SI 65 BP 159 EP 164 DI 10.2112/SI65-028.1 PN 1 PG 6 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA AJ8ZB UT WOS:000337995500029 ER PT S AU Doyle, JD Howard, IL AF Doyle, Jesse D. Howard, Isaac L. GP DEStech Publicat, Inc TI Rutting and Moisture Damage Resistance of High RAP Warm Mixed Asphalt: Loaded Wheel Tracking vs. Conventional Methods SO ASPHALT PAVING TECHNOLOGY 2013, VOL 82 SE Journal of the Association of Asphalt Paving Technologists LA English DT Proceedings Paper CT Conference of the Association-of-Asphalt-Paving-Technologists (AAPT) CY APR 07-10, 2013 CL Denver, CO SP Assoc Asphalt Paving Technologists DE loaded wheel tracking; WMA; RAP; rutting; moisture damage; PURWheel ID MIXTURES; PERFORMANCE; TECHNOLOGY; PAVEMENT AB An increased potential for moisture damage and rutting have been the two main problems with warm mix asphalt (WMA) implementation. The use of high reclaimed asphalt pavement (RAP) contents (25% or more) in WMA may alleviate these problems. At present, susceptibility to moisture damage and rutting are usually tested for independently; however, these distress mechanisms can be linked for in-service pavements. An enhanced loaded wheel tracking test performed on dry and wet specimens, the PURWheel, is investigated in this paper to evaluate the interaction of traffic and moisture. The PURWheel is also compared to conventional rutting and moisture damage tests. PURWheel results are used to evaluate performance of 25 and 50% RAP-WMA. Rutting and moisture susceptibility of the high RAP-WMA was comparable to current practice low RAP content hot mix asphalt (HMA). C1 [Doyle, Jesse D.] US Army Engineer Res & Dev Ctr, Airfields & Pavements Branch, Geotech & Struct Lab, Vicksburg, MS 39180 USA. [Howard, Isaac L.] Mississippi State Univ, Dept Civil & Environm Engn, Mississippi State, MS 39762 USA. RP Doyle, JD (reprint author), US Army Engineer Res & Dev Ctr, Airfields & Pavements Branch, Geotech & Struct Lab, Vicksburg, MS 39180 USA. NR 47 TC 3 Z9 3 U1 1 U2 2 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA SN 0270-2932 J9 J ASSOC ASPHALT PAV PY 2013 VL 82 BP 289 EP 325 DI 10.1080/14680629.2013.812841 PG 37 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA BA7HR UT WOS:000337539100010 ER PT J AU Tandon, A Brudnak, MJ Stein, JL Ersal, T AF Tandon, Akshar Brudnak, Mark J. Stein, Jeffrey L. Ersal, Tulga GP ASME TI AN OBSERVER BASED FRAMEWORK TO IMPROVE FIDELITY IN INTERNET-DISTRIBUTED HARDWARE-IN-THE-LOOP SIMULATIONS SO ASME 2013 DYNAMIC SYSTEMS AND CONTROL CONFERENCE, VOL 2 LA English DT Proceedings Paper CT ASME Dynamic Systems and Control Conference (DSCC) CY OCT 21-23, 2013 CL Palo Alto, CA SP ASME, Dynam Syst & Control Div ID BILATERAL TELEOPERATION; TELEMANIPULATION; TRANSPARENCY; DESIGN AB Co-simulating distributed hardware-in-the-loop systems in real time over the Internet entails communication delays that can lead to significant loss of fidelity and even instability in the system. To address this challenge, this paper proposes an observer based framework that, unlike previously reported efforts, does not require the observer to know and model the observed system dynamics. This is achieved by deriving the closed-loop dynamics of the observer based on a sliding surface. Even though the resulting error system does not necessarily stay on a sliding surface, its asymptotic convergence to zero is still guaranteed. First, this idea is developed for a generic networked system simulation framework and its stability is established. Then, it is applied to a mass-spring-damper system to illustrate the mechanics of the approach on a simple, linear example and demonstrate that the approach can stabilize the system that is otherwise unstable due to delay. Finally, a vehicle-engine-driver system simulation is considered to evaluate the performance of the approach on a more realistic, nonlinear example. An improvement of up to 33% is observed in the fidelity of the simulation. The conclusion is that the approach holds a significant potential to alleviate the negative impact of delay and improve the stability and fidelity of networked system simulations. Its benefits become more pronounced as the delay increases. C1 [Tandon, Akshar; Stein, Jeffrey L.; Ersal, Tulga] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. [Brudnak, Mark J.] US Army RDECOM TARDEC, Hardware & Man Loop Simulat, Warren, MI 48397 USA. RP Ersal, T (reprint author), Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. EM akshart@umich.edu; mark.j.brudnak.civ@mail.mil; stein@umich.edu; tersal@umich.edu FU Automotive Research Center (ARC); U.S. Army center of excellence FX This work was supported by the Automotive Research Center (ARC), a U.S. Army center of excellence in modeling and simulation of ground vehicles. NR 21 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-5613-0 PY 2013 AR UNSP V002T21A004 DI 10.1115/DSCC2013-3878 PG 9 WC Automation & Control Systems; Engineering, Mechanical SC Automation & Control Systems; Engineering GA BA5WL UT WOS:000337043200022 ER PT J AU Yheulon, CG Gagliano, RA AF Yheulon, Christopher G. Gagliano, Ronald A. TI Multiple Successful Emergent Peristomal Bowel Resections under Regional Anesthesia in a Patient with Colonic Pseudo-obstruction and Severe Chronic Obstructive Pulmonary Disease SO AMERICAN SURGEON LA English DT Article C1 [Yheulon, Christopher G.; Gagliano, Ronald A.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. RP Yheulon, CG (reprint author), Tripler Army Med Ctr, Dept Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM Christopher.yheulon@us.army.mil NR 4 TC 1 Z9 1 U1 0 U2 0 PU SOUTHEASTERN SURGICAL CONGRESS PI CUMMING PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA SN 0003-1348 EI 1555-9823 J9 AM SURGEON JI Am. Surg. PD JAN PY 2013 VL 79 IS 1 BP E47 EP E48 PG 2 WC Surgery SC Surgery GA AI6DT UT WOS:000336961200019 PM 23317608 ER PT J AU Weiss, CA Moser, RD Torres-Cancel, K Negron, OR Hidalgo-Hernandez, RG Allison, PG Chandler, MQ Morefield, SW Malone, PG AF Weiss, Charles A. Moser, Robert D. Torres-Cancel, Kevin Negron, Omar R. Hidalgo-Hernandez, Ruth G. Allison, P. G. Chandler, Mei Q. Morefield, Sean W. Malone, Philip G. TI Production of mixed carbonate phases using ammonium carbonate-metal acetate reactions SO BIOINSPIRED BIOMIMETIC AND NANOBIOMATERIALS LA English DT Article DE biomimetic materials; bioinspired; calcium carbonate; composites; electron microscopy; mineralisation; phase change materials; X-ray diffraction ID PRECIPITATION AB Materials such as bone, nacre, and fish scales have unique structures that give the material strength as well as ductility. The ultimate goal of our research is to develop new composite materials that have improved strength and ductility compared to conventional materials. The US Army Engineer Research and Development Center is incorporating these design principles to develop hierarchical materials for structural applications. In the present study, the mineralogy and morphology of calcium-containing carbonates precipitated by reacting (NH4)(2)CO3 with mixed Ca, Sr, Mg, and Mn-acetates was investigated. As the proportion of the non-Ca component increased, the products shifted toward double carbonates and mixtures of double carbonates with single carbonates. Characterization by scanning electron microscopy and X-ray diffraction to determine crystal sizes, morphology, and structure of precipitated phases indicated a potential for re-crystallizing the products to form new composite materials. Ongoing research efforts are focused on using information obtained in the present study to develop composites by hydrothermal recrystallization of metastable phases. C1 [Weiss, Charles A.; Moser, Robert D.; Torres-Cancel, Kevin; Hidalgo-Hernandez, Ruth G.; Allison, P. G.; Chandler, Mei Q.; Morefield, Sean W.; Malone, Philip G.] US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. [Negron, Omar R.] Univ Puerto Rico, Dept Mech Engn, Mayaguez, PR USA. RP Weiss, CA (reprint author), US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. EM charles.a.weiss@usace.army.mil FU Center-Directed Research Program of the US Army Engineer Research and Development Center FX The authors would like to acknowledge financial support for this work provided by the Center-Directed Research Program of the US Army Engineer Research and Development Center. Permission to publish was granted by Director, Geotechnical and Structures Laboratory. NR 13 TC 0 Z9 0 U1 0 U2 2 PU ICE PUBLISHING PI WESTMINISTER PA INST CIVIL ENGINEERS, 1 GREAT GEORGE ST, WESTMINISTER SW 1P 3AA, ENGLAND SN 2045-9858 EI 2045-9866 J9 BIOINSPIR BIOMIM NAN JI Bioinspired Biomim. Nanobiomat. PY 2013 VL 2 IS 2 BP 59 EP 64 DI 10.1680/bbn.12.00017 PG 6 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA AH8ZM UT WOS:000336427600002 ER PT S AU Zainuddin, S Hosur, MV Jeelani, S Kumar, A Trovillion, J AF Zainuddin, S. Hosur, M. V. Jeelani, S. Kumar, A. Trovillion, J. BE Bai, J TI Improving the durability of advanced fiber-reinforced polymer (FRP) composites using nanoclay SO ADVANCED FIBRE-REINFORCED POLYMER (FRP) COMPOSITES FOR STRUCTURAL APPLICATIONS SE Woodhead Publishing Series in Civil and Structural Engineering LA English DT Article; Book Chapter DE nanocomposites; environmental degradation; moisture absorption; flexure test ID LAYERED SILICATE NANOCOMPOSITES; EPOXY COMPOSITES; BARRIER PROPERTIES; MECHANICAL-PROPERTIES; CLAY NANOCOMPOSITES; WATER-ABSORPTION; GAS PERMEATION; MOISTURE; DAMAGE; GLASS AB In this chapter, we report the findings of experimental investigations conducted on durability of glass fiber-reinforced polymer (GFRP) composites with and without the addition of montmorillonite nanoclay. First, neat and nanoclay-added epoxy systems were characterized to evaluate the extent of clay platelet exfoliation and dispersion of nanoclay. GFRP composite panels were then fabricated with neat/modified epoxy resin and exposed to six different conditions, i.e. hot-dry/wet, cold-dry/wet, ultraviolet radiation and alternate ultraviolet radiation-condensation. Room temperature condition samples were also used for baseline consideration. An improved dispersion of nanoclay and exfoliation of clay platelets were observed in 2 wt% of epoxy samples. Weight change, discoloration and significant reduction in properties were observed in all conditioned GFRP samples. However, addition of nanoclay considerably improved the durability of GFRP samples as evident from the mechanical and micrographical results in comparison to neat samples subjected to similar conditions. C1 [Zainuddin, S.; Hosur, M. V.; Jeelani, S.] Tuskegee Univ, Dept Mat Sci & Engn, Tuskegee, AL 36088 USA. [Kumar, A.; Trovillion, J.] US Army Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61821 USA. RP Zainuddin, S (reprint author), Tuskegee Univ, Dept Mat Sci & Engn, Tuskegee, AL 36088 USA. EM szainuddin@mytu.tuskegee.edu; ashok.kumar@usace.army.mil NR 62 TC 0 Z9 0 U1 0 U2 3 PU WOODHEAD PUBL LTD PI CAMBRIDGE PA ABINGTON HALL ABINGTON, CAMBRIDGE CB1 6AH, CAMBS, ENGLAND SN 2052-4714 BN 978-0-85709-864-1; 978-0-85709-418-6 J9 WOOD PUBL SER CIVIL PY 2013 VL 46 BP 780 EP 813 DI 10.1533/9780857098641.4.780 D2 10.1533/9780857098641 PG 34 WC Engineering, Civil; Polymer Science SC Engineering; Polymer Science GA BA2CZ UT WOS:000333303300021 ER PT J AU Fletes, FJ Kwak, E Vanet, J AF Fletes, F. J. Kwak, E. Vanet, J. TI A COMPARISON OF THE UNITED STATES' FDA APPROVAL PROCESS AND EUROPEAN EMA APPROVAL PROCESS SO EUROPEAN PSYCHIATRY LA English DT Meeting Abstract C1 [Fletes, F. J.; Kwak, E.; Vanet, J.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER PI PARIS PA 23 RUE LINOIS, 75724 PARIS, FRANCE SN 0924-9338 EI 1778-3585 J9 EUR PSYCHIAT JI Eur. Psychiat. PY 2013 VL 28 SU 1 MA 2231 PG 1 WC Psychiatry SC Psychiatry GA AG5LN UT WOS:000335460601803 ER PT J AU Nelson, AJ Page, MA Ginsberg, MD Rood, MJ AF Nelson, Andrew J. Page, Martin A. Ginsberg, Mark D. Rood, Mark J. TI Bench-Scale Aerosol Filtration Test System and Evaluation of an Acoustic Bioaerosol Removal Device for Indoor Air Streams SO AEROSOL SCIENCE AND TECHNOLOGY LA English DT Article ID SUBMICROMETER PARTICLES; MICROORGANISMS; AGGLOMERATION; PERFORMANCE; FILTERS; WAVES; DESIGN AB It is important to have well-defined, reproducible methods to evaluate and compare newly developed air filtration equipment. To facilitate accurate assessment of air purification devices at the bench scale, an experimental system was designed, built, and documented to evaluate particulate removal efficiency (PRE) of air filtration devices based on principles used in ASHRAE standards. The system was then carefully characterized and used to evaluate PRE and total energy consumption of a novel acoustically enhanced impaction (AEI) air purification device. The AEI device demonstrated 99.998% PRE of 0.5-1.5m diameter KCl particles while causing a 120 Pa pressure drop and requiring a total of 3.0W/l of air treated at indoor ambient conditions. A single element of the AEI device operated in a biological safety level 2 facility was then used to evaluate PRE of bioaerosol consisting of Bacillus cereus (BC) spores. PRE of BC was 99.86 0.05% at indoor ambient temperature and pressure. This research describes the use of the Bench-scale Air Purification Testing and Evaluation Chamber (BAP-TEC) to experimentally evaluate and compare PRE and total energy requirements of novel air purification devices at the bench scale (280-1400 alpm). Further, an AEI device containing a fibrous filter media and high intensity sound field in the same control volume is evaluated using the BAP-TEC. Temporally resolved PRE of a bioaerosol by the AEI is also presented.Copyright 2013 American Association for Aerosol Research C1 [Nelson, Andrew J.; Page, Martin A.; Ginsberg, Mark D.] US Army Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. [Nelson, Andrew J.; Rood, Mark J.] Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61801 USA. RP Nelson, AJ (reprint author), US Army Engineer Res & Dev Ctr, Construct Engn Res Lab, POB 9005, Champaign, IL 61826 USA. EM Andrew.J.Nelson@usace.army.mil FU Defense Threat Reduction Agency; Department of Defense Science, Mathematics, and Research for Transformation (SMART) Scholarship FX Financial support is acknowledged from the Defense Threat Reduction Agency and the Department of Defense Science, Mathematics, and Research for Transformation (SMART) Scholarship administered by the American Society for Engineering Education. The authors would also like to thank Professor Tami Bond and Dr. Benjamin Brem for generously allowing access to equipment necessary for aerosol generation and analysis. NR 36 TC 0 Z9 0 U1 2 U2 12 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 520 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0278-6826 EI 1521-7388 J9 AEROSOL SCI TECH JI Aerosol Sci. Technol. PY 2013 VL 47 IS 12 BP 1285 EP 1292 DI 10.1080/02786826.2013.835026 PG 8 WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA AF8VM UT WOS:000334993700001 ER PT B AU Vorontsov, M Weyrauch, T Lachinova, S Ryan, T Deck, A Gatz, M Paramonov, V Carhart, G AF Vorontsov, Mikhail Weyrauch, Thomas Lachinova, Svetlana Ryan, Thomas Deck, Andrew Gatz, Micah Paramonov, Vladimir Carhart, Gary BE Brignon, A TI Coherent Beam Combining and Atmospheric Compensation with Adaptive Fiber Array Systems SO COHERENT LASER BEAM COMBINING LA English DT Article; Book Chapter ID PHASE-DISTORTION CORRECTION; KM PROPAGATION PATH; BASIC CONSIDERATIONS; DIRECTED-ENERGY; OPTICAL-SYSTEMS; SPECKLE-FIELD; HIGH-POWER; PROJECTION; OPTIMIZATION; COLLIMATORS C1 [Vorontsov, Mikhail; Weyrauch, Thomas; Gatz, Micah] Univ Dayton, Sch Engn, Intelligent Opt Lab, Dayton, OH 45469 USA. [Vorontsov, Mikhail; Lachinova, Svetlana; Ryan, Thomas; Deck, Andrew; Paramonov, Vladimir] Optonicus, Dayton, OH 45402 USA. [Carhart, Gary] US Army Res Lab, Computat & Informat Sci Directorate, Intelligent Opt Lab, Adelphi, MD 20783 USA. RP Vorontsov, M (reprint author), Univ Dayton, Sch Engn, Intelligent Opt Lab, 300 Coll Pk, Dayton, OH 45469 USA. NR 43 TC 5 Z9 5 U1 0 U2 1 PU BLACKWELL SCIENCE PUBL PI OXFORD PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND BN 978-3-527-65280-8; 978-3-527-41150-4 PY 2013 BP 167 EP 191 D2 10.1002/9783527652778 PG 25 WC Physics, Applied SC Physics GA BA1JQ UT WOS:000332649500007 ER PT J AU Verba, R Tiberkevich, V Bankowski, E Meitzler, T Melkov, G Slavin, A AF Verba, Roman Tiberkevich, Vasil Bankowski, Elena Meitzler, Thomas Melkov, Gennadiy Slavin, Andrei TI Localized Defect Modes in a Two-Dimensional Array of Magnetic Nanodots SO IEEE MAGNETICS LETTERS LA English DT Article DE Nanomagnetics; spin waves; magnonic crystal; magnetic dot; ferromagnetic resonance AB The microwave properties of an array of magnetic nanodots in a ferromagnetic state having a point defect-a dot with inverted magnetization or different material parameters-are considered. The existence of a single-point defect in a dot array may lead to the appearance of several localized modes: one "defect eigenmode" and several "well modes," the number and structure of which strongly depend on the magnetostatic interactions between the dots. By performing a ferromagnetic resonance experiment on an array of magnetic dots containing a small number of defects, it is possible to obtain information about the entire spin-wave spectrum of the array. C1 [Verba, Roman; Melkov, Gennadiy] Taras Shevchenko Natl Univ Kyiv, Fac Radiophys, UA-01601 Kiev, Ukraine. [Tiberkevich, Vasil; Slavin, Andrei] Oakland Univ, Dept Phys, Rochester, MI 48309 USA. [Bankowski, Elena; Meitzler, Thomas] US Army TARDEC, Warren, MI 48397 USA. RP Verba, R (reprint author), Taras Shevchenko Natl Univ Kyiv, Fac Radiophys, UA-01601 Kiev, Ukraine. EM verrv@ukr.net RI Tiberkevich, Vasil/A-8697-2008; Verba, Roman/J-4452-2014; Meitzler, Thomas/D-1065-2017 OI Tiberkevich, Vasil/0000-0002-8374-2565; Verba, Roman/0000-0001-8811-6232; FU National Science Foundation, USA [DMR-1015175]; U.S. Army TARDEC, RDECOM; DARPA MTO/MESO [N66001-11-1-4114]; SFFR (DFFD) of Ukraine [UU34/008] FX This work was supported by Grant DMR-1015175 from the the National Science Foundation, USA; by a contract from the U.S. Army TARDEC, RDECOM; by DARPA MTO/MESO under Grant N66001-11-1-4114; and by Grant UU34/008 from the SFFR (DFFD) of Ukraine. NR 13 TC 3 Z9 3 U1 1 U2 13 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1949-307X J9 IEEE MAGN LETT JI IEEE Magn. Lett. PY 2013 VL 4 AR 4000404 DI 10.1109/LMAG.2013.2277995 PG 4 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA AF7VD UT WOS:000334922100012 ER PT B AU Arney, C Coronges, K Fletcher, H Hagen, J Hutchinson, K Moss, A Thomas, C AF Arney, Chris Coronges, Kate Fletcher, Hilary Hagen, John Hutchinson, Kira Moss, Allen Thomas, Charles GP IEEE TI Using Rare Event Modeling & Networking to Build Scenarios and Forecast the Future SO PROCEEDINGS OF THE 2013 IEEE 2ND INTERNATIONAL NETWORK SCIENCE WORKSHOP (NSW) LA English DT Proceedings Paper CT IEEE 2nd Network Science Workshop (NSW) CY APR 29-MAY 01, 2013 CL West Point, NY SP IEEE, IEEE Comp Soc, Network Sci Ctr, Army Res Off, IEEE Task Force Network Sci DE black swan; tipping point; scenario; wargame; future planning AB Recent history has reminded society that prediction in the forms of scenario generation, red-teaming, war-gaming, and future planning must incorporate innovative perspectives such as rare, but impactful, events and multiple phased events. Rare event modeling is based on the premise that important events can be dominated by outliers. Current forecasting focuses on probable events. Likewise, multiple-phased actions can create paradigm shifts that move events in a new direction or push them to higher levels of impact. Therefore, impact potential must be understood, calculated, and utilized. Our network-based scenario development system provides for state-change and high-impact scenario events that enable impact measures to be calculated and used by decision makers. C1 [Arney, Chris; Coronges, Kate; Fletcher, Hilary; Hagen, John; Moss, Allen; Thomas, Charles] US Mil Acad, West Point, NY 10996 USA. [Hutchinson, Kira] Univ Foreign Mil & Cultural Studies, US Army Training & Doctrine Command, Ft Monrce, VA 23651 USA. RP Arney, C (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 17 TC 0 Z9 0 U1 0 U2 4 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4799-0436-5; 978-1-4799-0203-3 PY 2013 BP 31 EP 36 PG 6 WC Computer Science, Hardware & Architecture; Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BA4BC UT WOS:000335317000005 ER PT B AU Leung, A Dron, W Purnell, J Srivastava, J Mahapatra, A Roy, A Hancock, JP Aguirre, M Han, JW Wang, C Scott, L AF Leung, Alice Dron, William Purnell, Jon Srivastava, Jaideep Mahapatra, Amogh Roy, Atanu Hancock, John P. Aguirre, Matthew Han, Jiawei Wang, Chi Scott, Lisa GP IEEE TI Social Patterns: Community Detection Using Behavior-Generated Network Datasets SO PROCEEDINGS OF THE 2013 IEEE 2ND INTERNATIONAL NETWORK SCIENCE WORKSHOP (NSW) LA English DT Proceedings Paper CT IEEE 2nd Network Science Workshop (NSW) CY APR 29-MAY 01, 2013 CL West Point, NY SP IEEE, IEEE Comp Soc, Network Sci Ctr, Army Res Off, IEEE Task Force Network Sci DE community detection; group detection; clustering; rule-based behaviors; generated datasets; communication models AB A set of behavior rules, personal characteristics, group affiliations and roles was used to generate a dataset of mixed communication actions modeling those at a large organization. Several different approaches to community detection and modeling were applied to this generated dataset, in order to compare the strengths and range of applicability of different algorithms. Graph partitioning methods performed well at assigning membership to formal, exclusive groups such as organizational departments, if there is a priori knowledge of the target number of groups. SSDE-cluster, a fast and scalable algorithm, performed well in detecting normal departments and can be used when the number of groups is not known. It also was able to detect small overlapping groups, but with only moderate accuracy. Clique enumeration performed well in detecting small overlapping groups, when a priori knowledge of average group size was used. Different methods of constructing social network graphs from the mixed communication actions were investigated, as well as different link weighing methods. We conclude that behavior-generated datasets with complex and complete ground truths are useful for collaborative validation of different community and role detection and modeling methods. C1 [Leung, Alice; Dron, William] BBN Technol, Cambridge, MA 02138 USA. [Purnell, Jon] Microsoft, Mountain View, CA USA. [Srivastava, Jaideep; Mahapatra, Amogh] Univ Minnesota, Minneapolis, MN 55455 USA. [Hancock, John P.; Aguirre, Matthew] Artis Tech Inc, Fairfax, VA USA. [Han, Jiawei; Wang, Chi] Univ Illinois, Chicago, IL 60680 USA. [Scott, Lisa] Army Res Lab, Adelphi, MD USA. RP Leung, A (reprint author), BBN Technol, Cambridge, MA 02138 USA. EM aleung@bbn.com; wdron@bbn.com; jopurnel@microsoft.com; srivastava@cs.umn.edu; atanu@cs.umn.edu; johnh@artistech.com; matta@artistech.com; han@cs.uiuc.edu; chiwang1@illinois.edu OI Srivastava, Jaideep/0000-0001-9385-7545 NR 9 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4799-0436-5; 978-1-4799-0203-3 PY 2013 BP 82 EP 89 PG 8 WC Computer Science, Hardware & Architecture; Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BA4BC UT WOS:000335317000012 ER PT B AU James, J Mabry, F St Leger, A Cook, T Huggins, K AF James, John Mabry, Frank St Leger, Aaron Cook, Tom Huggins, Kevin GP IEEE TI Cyber-Physical Situation Awareness and Decision Support SO PROCEEDINGS OF THE 2013 IEEE 2ND INTERNATIONAL NETWORK SCIENCE WORKSHOP (NSW) LA English DT Proceedings Paper CT IEEE 2nd Network Science Workshop (NSW) CY APR 29-MAY 01, 2013 CL West Point, NY SP IEEE, IEEE Comp Soc, Network Sci Ctr, Army Res Off, IEEE Task Force Network Sci DE situation awareness; communication network; information network; social/cognitive network; cyber-physical AB Cyber-physical situation awareness is essential to management of government services and conduct of business processes. In particular, all of the nation's critical infrastructures depend upon proper operation of supervisory control and data acquisition (SCADA) devices and proper operation of these devices faces threats from possible occurrences of a variety of deliberate and inadvertent cyber events. This paper discusses an ongoing approach for incrementally improving cyber-physical situation awareness by (1) extending previous results for information architecture understanding, (2) sharing protected information among information owners whose knowledge (measurement) of their own state can be improved by choosing to share information with others, and (3) comparing measured cyber-physical system state to predicted cyber-physical system state. C1 [James, John; Mabry, Frank; St Leger, Aaron; Cook, Tom; Huggins, Kevin] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. RP James, J (reprint author), US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. EM John.James@usma.edu; Frank.Mabry@usma.edu; Aaron.StLeger@usma.edu; Tom.Cook@usma.edu; Kevin.Huggins@usma.edu NR 5 TC 0 Z9 0 U1 1 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4799-0436-5; 978-1-4799-0203-3 PY 2013 BP 114 EP 117 PG 4 WC Computer Science, Hardware & Architecture; Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BA4BC UT WOS:000335317000019 ER PT B AU Shakarian, P Subrahmanian, VS AF Shakarian, Paulo Subrahmanian, V. S. GP IEEE TI Geospatial Optimization Problems SO PROCEEDINGS OF THE 2013 IEEE 2ND INTERNATIONAL NETWORK SCIENCE WORKSHOP (NSW) LA English DT Proceedings Paper CT IEEE 2nd Network Science Workshop (NSW) CY APR 29-MAY 01, 2013 CL West Point, NY SP IEEE, IEEE Comp Soc, Network Sci Ctr, Army Res Off, IEEE Task Force Network Sci AB There are numerous applications which require the ability to take certain actions (e. g. distribute money, medicines, people etc.) over a geographic region in order to optimize an objective (e. g. minimize expected number of people with a disease). We introduce "geospatial optimization problems" (GOPs) where an agent has limited resources and budget to take actions in a geographic area. The actions result in one or more properties changing for one or more locations. There are also certain constraints on the combinations of actions that can be taken. We study two types of GOPs - goal-based and benefit-maximizing (GBGOP and BMGOP respectively). A GBGOP ensures that certain properties must be true at specified locations after the actions are taken while a BMGOP optimizes a linear benefit function. We present several approaches to these problems using various integer programs as well as a multiplicative update based approximation. C1 [Shakarian, Paulo] US Mil Acad, Network Sci Ctr, West Point, NY 10996 USA. [Subrahmanian, V. S.] Univ Maryland, Dept Comp Sci, College Pk, MD USA. RP Shakarian, P (reprint author), US Mil Acad, Network Sci Ctr, West Point, NY 10996 USA. EM paulo@shakarian.net; vs@cs.umd.edu FU Army Research Office [2GDATXR042]; U.S. Military Academy FX Some of the authors are supported under by the Army Research Office (project 2GDATXR042). The opinions in this paper are those of the authors and do not necessarily reflect the opinions of the funders, the U.S. Military Academy, or the U.S. Army. NR 3 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4799-0436-5; 978-1-4799-0203-3 PY 2013 BP 118 EP 121 PG 4 WC Computer Science, Hardware & Architecture; Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BA4BC UT WOS:000335317000020 ER PT B AU Cosenzo, KA Szymanski, BK AF Cosenzo, Keryl Ann Szymanski, Boleslaw Karol GP IEEE TI Challenges of Social Cognitive Network Science: Network Science Collaborative Technology Alliance Perspective SO PROCEEDINGS OF THE 2013 IEEE 2ND INTERNATIONAL NETWORK SCIENCE WORKSHOP (NSW) LA English DT Proceedings Paper CT IEEE 2nd Network Science Workshop (NSW) CY APR 29-MAY 01, 2013 CL West Point, NY SP IEEE, IEEE Comp Soc, Network Sci Ctr, Army Res Off, IEEE Task Force Network Sci DE social cognitive networks; communities; trust; team performance AB This paper reviews challenges and summarize the progress accomplished by the Social Cognitive Networks Academic Research Center of the Network Science Collaborative Technology Alliance. The focus is on potential impact that this research may have on unique needs of military, foremost the US Army, to effectively and efficiently operate in the increasingly complex and interconnected networks of societies and their component communities. The review of the progress and current status of research of the center provide state-of-the-art view of the relevant areas of social cognitive network science. C1 [Cosenzo, Keryl Ann] US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. [Szymanski, Boleslaw Karol] Rensselaer Polytech Inst, Social Cognit Networks Acad Res Ctr, Troy, NY USA. RP Cosenzo, KA (reprint author), US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. EM Keryl.a.Cosenz.civ@mail.mil; szymab@rpi.edu RI Szymanski, Boleslaw/A-9121-2009 OI Szymanski, Boleslaw/0000-0002-0307-6743 FU Army Research Laboratory [W911NF-09-2-0053] FX Research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-09-2-0053. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation here on. NR 9 TC 0 Z9 0 U1 1 U2 5 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4799-0436-5; 978-1-4799-0203-3 PY 2013 BP 122 EP 125 PG 4 WC Computer Science, Hardware & Architecture; Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BA4BC UT WOS:000335317000021 ER PT J AU Hsu, KY Yang, MH Jheng, DY Huang, SL Mennemann, K Dietrich, V Dubinskii, M AF Hsu, Kuang-Yu Yang, Mu-Han Jheng, Dong-Yo Huang, Sheng-Lung Mennemann, Karl Dietrich, Volker Dubinskii, Mark GP IEEE TI Single Crystalline YAG-core Fiber with a Lanthanum Dense Flint Glass Cladding SO 2013 CONFERENCE ON LASERS AND ELECTRO-OPTICS PACIFIC RIM (CLEO-PR) LA English DT Proceedings Paper CT 10th Conference on Lasers and Electro-Optics Pacific Rim (CLEO-PR) CY JUN 30-JUL 04, 2013 CL Kyoto, JAPAN SP IEICE Commun Soc, IEICE Elect Soc, Japan Soc Appl Phys, IEEE Photon Soc, Opt Soc, Opt Soc Korea, Korean Phys Soc, Agilent Technologies Japan Ltd, Hamamatsu Photon K K, Tektronix Japan, Thorlabs Japan Inc AB The crystalline YAG-core fiber cladded by high-index N-LaSF9 glass has been fabricated to significantly reduce the number of guided modes. The selective propagation of the LP01 and LP11 modes was successfully demonstrated at 633 nm. C1 [Hsu, Kuang-Yu; Yang, Mu-Han; Jheng, Dong-Yo; Huang, Sheng-Lung] Natl Taiwan Univ, Gratuate Inst Photon & Optoelect, Taipei 106, Taiwan. [Mennemann, Karl; Dietrich, Volker] Johannes Gutenberg Univ Mainz, Adv Opt, D-55122 Mainz, Germany. [Dubinskii, Mark] US Army, Res Lab, Adelphi, MD 20783 USA. RP Hsu, KY (reprint author), Natl Taiwan Univ, Gratuate Inst Photon & Optoelect, Taipei 106, Taiwan. EM slhuang@cc.ee.ntu.edu.tw NR 5 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4673-6476-8 PY 2013 PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BA3FB UT WOS:000334176100392 ER PT S AU Shay, LA Conti, G Hartzog, W AF Shay, Lisa A. Conti, Gregory Hartzog, Woodrow GP IEEE TI Beyond Sunglasses and Spray Paint: A Taxonomy of Surveillance Countermeasures SO 2013 IEEE INTERNATIONAL SYMPOSIUM ON TECHNOLOGY AND SOCIETY (ISTAS) SE IEEE International Symposium on Technology and Society LA English DT Proceedings Paper CT IEEE International Symposium on Technology and Society (ISTAS) CY JUN 27-29, 2013 CL Univ Toronto, Engn Bahen Ctr Informat Technol, Toronto, CANADA SP IEEE, Univ Toronto, IEEE Soc Social Implicat Technol, Univ Wollongong, Int Federat Med & Biol Engn, Prod Safety Engn Soc, ACM Comp Soc, Epson, APX Labs, MetaView, Autographer, Streamfolio, buildAR, Uberveillance, Optinvent, Cisco, Singularity Weblog, Augmented Real Org, Augmate Corp, Infin AR, Inst Infocomm Res HO Univ Toronto, Engn Bahen Ctr Informat Technol DE panopticon; uberveillance; veillance; surveillance; privacy; countermeasures AB The rapid decline in size and cost of networked sensors combined with increased incentives for use including monitoring physical fitness, improving public safety, increasing security, and adding convenience is causing the physical and online worlds to become heavily instrumented. Some welcome such developments, but others seek to retain privacy, often by focusing on countering the sensors themselves. Scholars have begun to consider surveillance countermeasures as a stand-alone area of research. However, a scholarly taxonomy useful for critical analysis and systematic countermeasure development is lacking. In this paper we provide such a taxonomy illustrated with example countermeasures that have been successfully employed. C1 [Shay, Lisa A.; Conti, Gregory] US Mil Acad, Cyber Res Ctr, West Point, NY 10996 USA. [Hartzog, Woodrow] Samford Univ, Cumberland Sch Law, Homewood, AL 35229 USA. RP Shay, LA (reprint author), US Mil Acad, Cyber Res Ctr, West Point, NY 10996 USA. EM lisa.shay@usma.edu; gregory.conti@usma.edu; whartzog@samford.edu NR 108 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2158-3404 BN 978-1-4799-1242-1; 978-1-4799-0929-2 J9 INT SYMP TECHNOL SOC PY 2013 BP 191 EP 200 PG 10 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BA2ZW UT WOS:000334028200025 ER PT J AU Champagne, VK Helfritch, DJ AF Champagne, Victor K. Helfritch, Dennis J. TI A demonstration of the antimicrobial effectiveness of various copper surfaces SO JOURNAL OF BIOLOGICAL ENGINEERING LA English DT Article ID BACTERIAL-CONTAMINATION; ESCHERICHIA-COLI AB Background: Bacterial contamination on touch surfaces results in increased risk of infection. In the last few decades, work has been done on the antimicrobial properties of copper and its alloys against a range of micro-organisms threatening public health in food processing, healthcare and air conditioning applications; however, an optimum copper method of surface deposition and mass structure has not been identified. Results: A proof-of-concept study of the disinfection effectiveness of three copper surfaces was performed. The surfaces were produced by the deposition of copper using three methods of thermal spray, namely, plasma spray, wire arc spray and cold spray The surfaces were then inoculated with meticillin-resistant Staphylococcus aureus (MRSA). After a two hour exposure to the surfaces, the surviving MRSA were assayed and the results compared. The differences in the copper depositions produced by the three thermal spray methods were examined in order to explain the mechanism that causes the observed differences in MRSA killing efficiencies. The cold spray deposition method was significantly more effective than the other methods. It was determined that work hardening caused by the high velocity particle impacts created by the cold spray technique results in a copper microstructure that enhances ionic diffusion, and copper ions are principally responsible for antimicrobial activity. Conclusions: This test showed significant microbiologic differences between coatings produced by different spray techniques and demonstrates the importance of the copper application technique. The cold spray technique shows superior anti-microbial effectiveness caused by the high impact velocity imparted to the sprayed particles which results in high dislocation density and high ionic diffusivity. C1 [Champagne, Victor K.] US Army Res Lab, Aberdeen Proving Ground, MD USA. [Helfritch, Dennis J.] Dynam Sci, Aberdeen, MD 21001 USA. RP Helfritch, DJ (reprint author), Dynam Sci, Aberdeen, MD 21001 USA. EM dennis.j.helfritch.ctr@mail.mil NR 21 TC 8 Z9 9 U1 2 U2 17 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1754-1611 J9 J BIOL ENG JI J. Biol. Eng. PY 2013 VL 7 IS 1 AR 8 DI 10.1186/1754-1611-7-8 PG 6 WC Biochemical Research Methods; Biotechnology & Applied Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology GA AE6JH UT WOS:000334096700007 PM 23537176 ER PT S AU Theisen, BL Kosinski, A AF Theisen, Bernard L. Kosinski, Andrew BE Roning, J Casasent, D TI The 20TH Annual Intelligent Ground Vehicle Competition: Building a Generation of Robotists SO INTELLIGENT ROBOTS AND COMPUTER VISION XXX: ALGORITHMS AND TECHNIQUES SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Intelligent Robots and Computer Vision XXX - Algorithms and Techniques CY FEB 04-06, 2013 CL Burlingame, CA SP Soc Imaging Sci & Technol, SPIE, Qualcomm Inc DE intelligent robots; autonomous systems; ground vehicles; vehicle control; engineering education; IGVC AB The Intelligent Ground Vehicle Competition (IGVC) is one of four, unmanned systems, student competitions that were founded by the Association for Unmanned Vehicle Systems International (AUVSI). The IGVC is a multidisciplinary exercise in product realization that challenges college engineering student teams to integrate advanced control theory, machine vision, vehicular electronics and mobile platform fundamentals to design and build an unmanned system. Teams from around the world focus on developing a suite of dual-use technologies to equip ground vehicles of the future with intelligent driving capabilities. Over the past 20 years, the competition has challenged undergraduate, graduate and Ph.D. students with real world applications in intelligent transportation systems, the military and manufacturing automation. To date, teams from over 80 universities and colleges have participated. This paper describes some of the applications of the technologies required by this competition and discusses the educational benefits. The primary goal of the IGVC is to advance engineering education in intelligent vehicles and related technologies. The employment and professional networking opportunities created for students and industrial sponsors through a series of technical events over the four-day competition are highlighted. Finally, an assessment of the competition based on participation is presented. C1 [Theisen, Bernard L.; Kosinski, Andrew] US Army TARDEC, Warren, MI 48397 USA. RP Theisen, BL (reprint author), US Army TARDEC, 6501 E Eleven Mile Rd, Warren, MI 48397 USA. EM bernard.theisen@us.army.mil; andrew.kosinski@us.army.mil NR 13 TC 0 Z9 0 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-9435-1 J9 PROC SPIE PY 2013 VL 8662 AR 866203 DI 10.1117/12.2010206 PG 15 WC Engineering, Electrical & Electronic; Robotics; Optics SC Engineering; Robotics; Optics GA BA2ZI UT WOS:000334022000002 ER PT J AU Grantner, J Bazuin, B Fajardo, C Hathaway, R Al-shawawreh, J Dong, L Castanier, MP Hussain, S AF Grantner, Janos Bazuin, Bradley Fajardo, Claudia Hathaway, Richard Al-shawawreh, Jumana Dong, Liang Castanier, Matthew P. Hussain, Shabbir GP IEEE TI Linguistic Model for Engine Power Loss SO PROCEEDINGS OF THE 2013 IEEE SYMPOSIUM ON COMPUTATIONAL INTELLIGENCE IN VEHICLES AND TRANSPORTATION SYSTEMS (CIVTS) LA English DT Proceedings Paper CT IEEE Symposium on Computational Intelligence in Vehicles and Transportation Systems (CIVTS) CY APR 16-19, 2013 CL Singapore, SINGAPORE SP IEEE, IEEE Computat Intelligence Soc DE Condition Based Maintenance; fuzzy model; engine power loss; intelligent diagnostics ID FUZZY AB Army ground vehicles often operate in extremely severe environmental and battlefield conditions. Condition Based Maintenance (CBM) allows maintenance to be performed based on evidence of need provided by reliability modeling and/or other enabling technologies, thus reducing maintenance costs and increasing vehicle availability. A Takagi-Sugeno fuzzy model is developed to diagnose the loss of engine power of light trucks. Baseline data are acquired through engine performance measurements. The Adaptive Neuro-Fuzzy (ANFIS) training method is used to extract the fuzzy rules. To improve the quality of the model a combination of the least-square error and the backpropagation gradient descent methods is implemented to minimize the errors. C1 [Grantner, Janos; Bazuin, Bradley] Western Michigan Univ, Dept Elect & Comp Engn, Kalamazoo, MI 49008 USA. [Fajardo, Claudia; Hathaway, Richard] Western Michigan Univ, Dept Aeronaut & Mech Engn, Kalamazoo, MI 49008 USA. [Dong, Liang] Baylor Univ, Baytown, TX USA. [Castanier, Matthew P.; Hussain, Shabbir] US Army RDECOM TARDEC, Warren, MI 48397 USA. RP Grantner, J (reprint author), Western Michigan Univ, Dept Elect & Comp Engn, Kalamazoo, MI 49008 USA.; Grantner, J (reprint author), Western Michigan Univ, Dept Aeronaut & Mech Engn, Kalamazoo, MI 49008 USA. EM janos.grantner@wmich.edu; matt.castanier@us.army.mil FU U.S. Army TARDEC [W56HZV-08-C-0236]; Mississippi State University FX This material is based, in part, upon work supported by the U.S. Army TARDEC under Contract No. W56HZV-08-C-0236, through a subcontract with Mississippi State University, and was performed for the Simulation Based Reliability and Safety (SimBRS) research program. UNCLASSIFIED: Dist A. Approved for public release. NR 6 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4673-5913-9 PY 2013 BP 80 EP 86 PG 7 WC Automation & Control Systems; Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic; Transportation Science & Technology SC Automation & Control Systems; Computer Science; Engineering; Transportation GA BA2TR UT WOS:000333897600012 ER PT J AU Gupta, A Spryn, M Kim, B Edwards, E Brantley, C Ruffin, P AF Gupta, Anurag Spryn, Mitchell Kim, Bruce Edwards, Eugene Brantley, Christina Ruffin, Paul GP IEEE TI Packaging and Sensing Platform using Opto-electronic Zinc Oxide Nano-Heterostructure Integration SO 2013 IEEE 63RD ELECTRONIC COMPONENTS AND TECHNOLOGY CONFERENCE (ECTC) LA English DT Proceedings Paper CT IEEE 63rd Electronic Components and Technology Conference (ECTC) CY MAY 28-31, 2013 CL Las Vegas, NV SP IEEE, IEEE Components, Packaging & Mfg Technol Soc ID NANOWIRES; FUNCTIONALIZATION AB In this work we report the sensing behavior of zinc oxide/pyrenebutyric acid nano-heterostructure and subsequent packaging of the sensor. High quality zinc oxide nanowires were synthesized and appropriately characterized. Surface of zinc oxide nanowires were engineered with optically active pyrenebutyric acid. Time dependent fluorescence quenching of the nano-heterostructure was utilized as a means to establish sensing behavior in presence of p-nitrophenol analyte. Furthermore, electrical characterization of pristine and surface-engineered zinc oxide nanowire chip is also reported. Based on these findings it was determined that the synthesized nano-heterostructure was capable of sensitive detection of p-nitrophenol vapor under ambient conditions. However, successful operation and reliable data is critically dependent on the analog sensor circuit design and subsequent packaging. Herein, we demonstrate a packaging strategy for integrating the sensing chip into a complete platform. Challenges with system integration are highlighted and a possible packaging approach for high sensitivity detection is outlined. C1 [Gupta, Anurag; Spryn, Mitchell; Kim, Bruce] Univ Alabama, Tuscaloosa, AL 35487 USA. [Edwards, Eugene; Brantley, Christina; Ruffin, Paul] US Army, AMRDEC, RDECOM, Redstone Arsenal, AL 35898 USA. RP Gupta, A (reprint author), Univ Alabama, Tuscaloosa, AL 35487 USA. EM anuragg@ieee.org FU U. S. Army [W31P4Q-09-D-0028]; AMRDEC in Huntsville, AL FX This work was partially funded by U. S. Army Contract No. W31P4Q-09-D-0028, AMRDEC in Huntsville, AL. NR 24 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4799-0233-0 PY 2013 BP 2271 EP 2275 PG 5 WC Engineering, Electrical & Electronic SC Engineering GA BA1ON UT WOS:000332764900357 ER PT J AU Stelle, LJ Hargrave, ML AF Stelle, Lenville J. Hargrave, Michael L. TI Messages in a Map: French Depictions of the 1730 Meskwaki Fort SO HISTORICAL ARCHAEOLOGY LA English DT Article AB In 1730, French and allied tribes besieged an expedient fortification hastily constructed by the Meskwaki in a small oak grove on the central Illinois prairie. Three written narratives and four maps produced by the French shortly after the battle agree in many ways, but the maps differ dramatically in how they depict the fort's geometry. The one produced in New Orleans and showing an irregularly shaped fortification corresponds most closely to the archaeological deposits revealed by a magnetic gradient survey and ground-truthing excavations. Multiple lines of evidence converge to force the conclusion that 11ML6 is the location of the 1730 fortification. More broadly, several factors are discussed that may help account for the confusing variations observed among the four maps, including cultural and professional biases, motives of personal aggrandizement, and differences in the maps' intended functions and stages of refinement. C1 [Stelle, Lenville J.] Parkland Coll, Dept Social Sci, Champaign, IL 61821 USA. [Hargrave, Michael L.] ERDC CERL, Champaign, IL 61826 USA. RP Stelle, LJ (reprint author), Parkland Coll, Dept Social Sci, 2400 West Bradley Ave, Champaign, IL 61821 USA. NR 47 TC 0 Z9 0 U1 0 U2 5 PU SOC HISTORICAL ARCHAEOLOGY PI ROCKVILLE PA 9707 KEY WEST AVENUE, STE 100, ROCKVILLE, MD 20850 USA SN 0440-9213 J9 HIST ARCHAEOL JI Hist. Archaeol. PY 2013 VL 47 IS 4 BP 23 EP 44 PG 22 WC Archaeology SC Archaeology GA AE1JY UT WOS:000333726800002 ER PT B AU Biddle, J Brigada, D Lapadula, A Buller, M Mullen, S AF Biddle, Jason Brigada, David Lapadula, Anthony Buller, Mark Mullen, Stephen GP IEEE TI OBAN: An Open Architecture Prototype for a Tactical Body Sensor Network SO 2013 IEEE INTERNATIONAL CONFERENCE ON BODY SENSOR NETWORKS (BSN) LA English DT Proceedings Paper CT IEEE International Conference on Body Sensor Networks CY MAY 06-09, 2013 CL MIT Media Lab, Cambridge, MA SP IEEE HO MIT Media Lab DE body sensor network; open systems architecture AB Dismounted warfighters face a variety of environmental and physical challenges that can degrade performance and lead to serious injury. Real-time monitoring of physiological status can be a key component of reducing these risks. To these ends, a Real-Time Physiological Status Monitoring (RT-PSM) system named OBAN (Open Body Area Network) is being developed. This system utilizes an Open Systems Architecture approach which will allow for the inclusion of new sensor modalities and display form factors at low cost. A prototype has been built using both Commercial-Off-The-Shelf (COTS) and custom-designed sensors to demonstrate the feasibility of this approach. The current system accepts heart rate data from a commercial sensor to calculate the subject's Physiological Strain Index (PSI), which is an indication of susceptibility to heat injury, and data from custom, boot-mounted load sensors. COTS components were adapted to create the system's networking and computational modules. Limitations of the existing prototype are described and a path forward addressing the operational needs of warfighters is proposed. C1 [Biddle, Jason; Brigada, David; Lapadula, Anthony] MIT, Lincoln Lab, 244 Wood St, Lexington, MA 02173 USA. [Buller, Mark; Mullen, Stephen] US Army, Environm Med Res Inst, Natick, MA 01760 USA. RP Lapadula, A (reprint author), MIT, Lincoln Lab, 244 Wood St, Lexington, MA 02173 USA. EM jbiddle@ll.mit.edu; david.brigada@ll.mit.edu; anthony.lapadula@ll.mit.edu; mark.j.buller@us.army.mil; stephen.mullen@us.army.mil FU United States Army Research Institute of Environmental Medicine under Air Force [FA8721-05-C-0002]; USARIEM FX This work is sponsored by the United States Army Research Institute of Environmental Medicine under Air Force Contract #FA8721-05-C-0002. The views expressed are those of the authors and do not reflect the official policy of the Department of Army, Department of Defense, or the U.S. Government.; We would like to thank Dr. Reed Hoyt of USARIEM for his support of this project. We are also grateful to the entire OBAN development team at MIT Lincoln Laboratory. NR 12 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4799-0330-6; 978-1-4799-0331-3 PY 2013 PG 6 WC Engineering, Biomedical; Engineering, Electrical & Electronic SC Engineering GA BA2DO UT WOS:000333337600065 ER PT B AU Clements, CM Moody, D Potter, AW Seay, JF Fellin, RE Buller, MJ AF Clements, Cynthia M. Moody, Derek Potter, Adam W. Seay, Joseph F. Fellin, Rebecca E. Buller, Mark J. GP IEEE TI Loaded and Unloaded Foot Movement Differentiation Using Chest Mounted Accelerometer Signatures SO 2013 IEEE INTERNATIONAL CONFERENCE ON BODY SENSOR NETWORKS (BSN) LA English DT Proceedings Paper CT IEEE International Conference on Body Sensor Networks CY MAY 06-09, 2013 CL MIT Media Lab, Cambridge, MA SP IEEE HO MIT Media Lab ID WALKING; PREDICTION; SIMULATION; HEAT; COST AB Heavy loads often subject foot soldiers and first-responders to increased risk musculoskeletal injury (MSI). Identifying excessive loads in real-time could help identify when soldiers are at greater risk of MSI. Using Principal Component Analysis (PCA) we derived a loaded (>35 kg) versus unloaded Naive Bayesian classification model from 22 male Soldiers (age 20 +/- 3.5 yrs, height 1.76 +/- 0.09 m and weight 83 +/- 13 kg). Using seven-fold cross validation we demonstrated that using only one feature our model accurately classifies heavily loaded versus unloaded over 90% of the time. This technique lends itself to use in real time accelerometry sensors and shows promise for more complex gait analysis. C1 [Clements, Cynthia M.; Moody, Derek; Potter, Adam W.; Seay, Joseph F.; Fellin, Rebecca E.; Buller, Mark J.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. RP Clements, CM (reprint author), US Army, Environm Med Res Inst, Natick, MA 01760 USA. NR 20 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4799-0330-6; 978-1-4799-0331-3 PY 2013 PG 5 WC Engineering, Biomedical; Engineering, Electrical & Electronic SC Engineering GA BA2DO UT WOS:000333337600068 ER PT B AU Gribok, A Rumpler, W Hoyt, R Buller, M AF Gribok, Andrei Rumpler, William Hoyt, Reed Buller, Mark GP IEEE TI Functional regression for data fusion and indirect measurements of physiological variables collected by wearable sensor systems and indirect calorimetry SO 2013 IEEE INTERNATIONAL CONFERENCE ON BODY SENSOR NETWORKS (BSN) LA English DT Proceedings Paper CT IEEE International Conference on Body Sensor Networks CY MAY 06-09, 2013 CL MIT Media Lab, Cambridge, MA SP IEEE HO MIT Media Lab DE functional regression; inference; smoothing; wearable sensors AB The paper describes application of different types of functional regression for analysis and modeling of the data collected by wearable sensor systems. The data have been recorded from human subjects while they were staying in whole room calorimeter chamber for 48 hours. This allowed very accurate measurements of their oxygen consumption, energy expenditure and substrate oxidation. These physiological parameters are notorious for their inaccuracy when measured in field conditions. The subjects wore two types of body sensors: the Hidalgo Equivital (TM) (Cambridge, UK) physiological monitors with a telemetry thermometer pill and iPro Professional Continuous Glucose Monitoring System (CGMS) (Medtronic MiniMed, Inc, Northridge, CA). The data collected by these two systems and by the calorimeter chamber were subsequently analyzed off-line using the functional regression techniques. The energy expenditure, substrate oxidation, and body core temperature were used as response variables, while heart rate, respiratory rate, subcutaneous glucose concentration, and skin temperature were used as predictors. The results show that the 24-hours and instantaneous energy expenditure values can be inferred from instantaneous measurements of heart rate, respiratory rate and glucose concentrations. Also, the body core temperature can be inferred from heart rate, respiratory rate, glucose concentration, and skin temperature. The substrate oxidation was the most difficult parameter to infer and it can only be accomplished during the exercise activity. C1 [Gribok, Andrei; Rumpler, William] USDA ARS, Beltsville Human Nutr Res Ctr, Food Components & Hlth Lab, Beltsville, MD 20705 USA. [Hoyt, Reed; Buller, Mark] US Army, Inst Environm Med, Biophys & Biomed Modeling Div, Natick, MA 01760 USA. RP Gribok, A (reprint author), USDA ARS, Beltsville Human Nutr Res Ctr, Food Components & Hlth Lab, Beltsville, MD 20705 USA. FU Defense Medical Research and Development Program (DMRDP) FX This work has been funded by Defense Medical Research and Development Program (DMRDP) Advanced Technology Development Research Award NR 8 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4799-0330-6; 978-1-4799-0331-3 PY 2013 PG 6 WC Engineering, Biomedical; Engineering, Electrical & Electronic SC Engineering GA BA2DO UT WOS:000333337600008 ER PT B AU Williamson, JR Fischl, K Dumas, A Hess, A Hughes, T Buller, MJ AF Williamson, James R. Fischl, Kate Dumas, Andrew Hess, Austin Hughes, Tadd Buller, Mark J. GP IEEE TI Individualized Detection of Ambulatory Distress in the Field using Wearable Sensors SO 2013 IEEE INTERNATIONAL CONFERENCE ON BODY SENSOR NETWORKS (BSN) LA English DT Proceedings Paper CT IEEE International Conference on Body Sensor Networks CY MAY 06-09, 2013 CL MIT Media Lab, Cambridge, MA SP IEEE HO MIT Media Lab DE musculoskeletal injury; gait analysis; gait asymmetry; accelerometry; load carriage; feature extraction AB The early onset of musculoskeletal injury during ambulation may be detectable due to changes in gait. Body worn accelerometers provide the ability for real-time monitoring and detection of these changes, thereby providing a means for avoiding further injury. We propose algorithms for extracting magnitude and pattern asymmetry features from accelerometers attached to each foot. By registering simultaneous acceleration differences between the two feet, these features provide robustness to a variety of confounding factors, such as changes in walking speed and load carriage. By computing only summary statistics from the acceleration signals, the algorithms can be easily implemented in real-time physiological status monitoring systems. We evaluate the algorithms on a field collection consisting of 32 subjects completing a series of 5 km marches under different loading conditions. We show that changes in the magnitude and pattern asymmetry features are predictive of subject ratings of physical pain and discomfort. C1 [Williamson, James R.; Fischl, Kate; Dumas, Andrew; Hess, Austin; Hughes, Tadd] MIT, Lincoln Lab, 244 Wood St, Lexington, MA 02173 USA. [Buller, Mark J.] US Army, Environm Med Res Inst, Natick, MA USA. RP Williamson, JR (reprint author), MIT, Lincoln Lab, 244 Wood St, Lexington, MA 02173 USA. FU United States Army Research Institute of Environmental Medicine under United States Air Force [FA8721- 05-C-0002] FX This work was sponsored by the United States Army Research Institute of Environmental Medicine under United States Air Force Contract FA8721- 05-C-0002. Opinions, interpretations, conclusions, and recommendations are those of the author and are not necessarily endorsed by the United States Government. NR 8 TC 0 Z9 0 U1 0 U2 3 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4799-0330-6; 978-1-4799-0331-3 PY 2013 PG 6 WC Engineering, Biomedical; Engineering, Electrical & Electronic SC Engineering GA BA2DO UT WOS:000333337600071 ER PT J AU Wright, KM Cabrera, OA Adler, AB Bliese, PD AF Wright, Kathleen M. Cabrera, Oscar A. Adler, Amy B. Bliese, Paul D. TI Functional Impairment as a Variable in Adjustment Post-Combat SO MILITARY PSYCHOLOGY LA English DT Article DE anger/aggression; depression; functional impairment; postcombat recovery; posttraumatic stress disorder ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; PRIMARY-CARE; IRAQ WAR; SOLDIERS; MODELS; MILITARY; TRAJECTORIES; PREVALENCE; IMPUTATION AB This study examined how functional impairment relates to postcombat adjustment over time, controlling for the influence of combat exposure. Analyses used sequential random coefficient models to examine 2 hypotheses: a) combat exposure and functional impairment predict the change in posttraumatic stress, depression, and anger/aggression symptoms during the first year postcombat; and b) combat exposure and functional impairment at reintegration predict symptom scores at 1 year postdeployment. A Brigade Combat Team completed surveys at reintegration, 4 months, and 12 months after a 1-year deployment to Iraq. Soldiers reporting high functional impairment at reintegration had higher symptoms at both follow-up periods, and functional impairment was a significant predictor of symptoms at the last time point, even after accounting for the influence of combat exposure. There was also an interaction effect, such that functional impairment exacerbated the impact of combat exposure on posttraumatic stress and anger/aggression symptoms at 12 months postdeployment. C1 [Wright, Kathleen M.; Adler, Amy B.] Walter Reed Army Inst Res, Heidelberg, Germany. [Cabrera, Oscar A.; Bliese, Paul D.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Cabrera, OA (reprint author), US Army Combat Readiness Safety Ctr, Ft Rucker, AL 36362 USA. EM oscar.a.cabrera2.mil@mail.mil NR 30 TC 2 Z9 2 U1 2 U2 4 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0899-5605 EI 1532-7876 J9 MIL PSYCHOL JI Milit. Psychol. PY 2013 VL 25 IS 6 BP 545 EP 556 DI 10.1037/mil0000018 PG 12 WC Psychology, Multidisciplinary SC Psychology GA AD9MT UT WOS:000333589900002 ER PT J AU Foran, HM Adler, AB AF Foran, Heather M. Adler, Amy B. TI Trainee Perceptions of Drill Sergeant Qualities During Basic Combat Training SO MILITARY PSYCHOLOGY LA English DT Article DE military; basic training; depression; anxiety symptoms; leadership ID MENTAL-HEALTH PROBLEMS; UNIT EFFECTIVENESS; PTSD SYMPTOMS; LEADERSHIP; DEPRESSION; SOLDIERS; RECRUITS; ANXIETY; STRESS; NAVY AB Basic combat training plays an important role in military service with approximately 72,000 soldiers participating in the United States annually. Although Drill Sergeant qualities have been widely portrayed in popular media, there is very little empirical research that documents the characteristics of Drill Sergeants and the impact these characteristics may have on trainees. In this study we evaluated a measure of perceived Drill Sergeant qualities and the degree to which these qualities related to mental health symptoms and job-related outcomes of trainees. Three types of perceived Drill Sergeant qualities were found from factor analyses: motivation, respect, and toughness. Using latent growth curve analyses, higher initial scores on motivation and respect, but not toughness, were associated with greater decreases in mental health symptoms over time. Further, changes in perceived Drill Sergeant qualities related to changes in depressive symptoms, unit cohesion, and citizen behaviors assessed over the course of basic combat training. C1 [Foran, Heather M.; Adler, Amy B.] Walter Reed Army Inst Res, US Army Med Res Unit Europe, Sambach, Germany. [Foran, Heather M.] Tech Univ Carolo Wilhelmina Braunschweig, Braunschweig, Germany. RP Foran, HM (reprint author), US Army Med Res Unit Europe, APO, AE 09136 USA. EM heatherforan@gmail.com NR 38 TC 3 Z9 3 U1 1 U2 2 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0899-5605 EI 1532-7876 J9 MIL PSYCHOL JI Milit. Psychol. PY 2013 VL 25 IS 6 BP 577 EP 587 DI 10.1037/mil0000023 PG 11 WC Psychology, Multidisciplinary SC Psychology GA AD9MT UT WOS:000333589900005 ER PT J AU Gallus, JA Walsh, BM van Driel, M Gouge, MC Antolic, E AF Gallus, Jessica A. Walsh, Benjamin M. van Driel, Marinus Gouge, Melissa C. Antolic, Emily TI Intolerable Cruelty: A Multilevel Examination of the Impact of Toxic Leadership on US Military Units and Service Members SO MILITARY PSYCHOLOGY LA English DT Article DE toxic leadership; climate; civility; incivility; command climate ID TRICKLE-DOWN MODEL; ABUSIVE SUPERVISION; INTERRATER RELIABILITY; JOB-SATISFACTION; RESPONSE BIAS; ORGANIZATIONS; CLIMATE; ENVIRONMENTS; PERSONALITY; FOLLOWERS AB We examined the effects of toxic leadership on unit and employee outcomes. Based on Bandura's social learning theory (1977), we predicted that toxic leadership would have a direct impact on unit civility and that unit civility would mediate the relationship between toxic leadership and job satisfaction and organizational commitment. We also predicted that within-unit variability in perceptions of toxic leadership, or toxic leadership congruence, would moderate these effects such that the relationship between toxic leadership and unit and employee outcomes would be stronger when unit members had similar perceptions of their leader's engagement in toxic behavior. Results indicate that toxic leadership behavior is negatively related to unit civility and that unit civility mediates the relationship between toxic leadership and job satisfaction and organizational commitment. Contrary to expectations, toxic leadership congruence did not moderate any of the effects of toxic leadership behavior. Implications for research and practice are discussed. C1 [Gallus, Jessica A.] US Army, Res Inst Behav & Social Sci, Ft Belvoir, VA 22060 USA. [Walsh, Benjamin M.] Univ Illinois Springield, Dept Management, Springfield, IL USA. [van Driel, Marinus] Van Driel Consulting, Satellite Beach, FL USA. [Gouge, Melissa C.] George Mason Univ, Dept Sociol & Anthropol, Consortium Fellows Res Program, Fairfax, VA 22030 USA. [Antolic, Emily] George Mason Univ, Dept Psychol, Consortium Fellows Res Program, Fairfax, VA 22030 USA. RP Gallus, JA (reprint author), US Army, Res Inst Behav & Social Sci, Fdn Sci Res Unit, 6000 6th St, Ft Belvoir, VA 22060 USA. EM jessica.gallus@gmail.com NR 54 TC 0 Z9 0 U1 5 U2 14 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0899-5605 EI 1532-7876 J9 MIL PSYCHOL JI Milit. Psychol. PY 2013 VL 25 IS 6 BP 588 EP 601 DI 10.1037/mil0000022 PG 14 WC Psychology, Multidisciplinary SC Psychology GA AD9MT UT WOS:000333589900006 ER PT J AU Mell, P Harang, R AF Mell, Peter Harang, Richard GP IEEE TI Limitations to Threshold Random Walk Scan Detection and Mitigating Enhancements SO 2013 IEEE CONFERENCE ON COMMUNICATIONS AND NETWORK SECURITY (CNS) LA English DT Proceedings Paper CT 1st IEEE International Conference on Communications and Network Security (CNS) CY OCT 14-16, 2013 CL Washington, DC SP IEEE, VeriSign Corp, Virginia Techs Hume Ctr DE Intrusion Detection; Scanning AB This paper discusses limitations in one of the most widely cited single source scan detection algorithms: threshold random walk (TRW). If an attacker knows that TRW is being employed, these limitations enable full circumvention allowing undetectable high speed full horizontal and vertical scanning of target networks from a single Internet Protocol address. To mitigate the discovered limitations, we provide 3 enhancements to TRW and analyze the increased cost in computational complexity and memory. Even with these mitigations in place, circumvention is still possible but only through collaborative scanning (something TRW was not designed to detect) with a significant increase in the required level of effort and usage of resources. C1 [Mell, Peter] NIST, Gaithersburg, MD 20899 USA. [Harang, Richard] US Army, Res Lab, Adelphi, MD USA. RP Mell, P (reprint author), NIST, Gaithersburg, MD 20899 USA. EM peter.mell@nist.gov; richard.e.harang.ctr@mail.mil NR 11 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4799-0895-0 PY 2013 BP 332 EP 340 PG 9 WC Computer Science, Hardware & Architecture; Computer Science, Theory & Methods; Telecommunications SC Computer Science; Telecommunications GA BA1QL UT WOS:000332881600038 ER PT B AU Cox, MS AF Cox, Marcus S. BA Cox, MS BF Cox, MS TI SEGREGATED SOLDIERS MILITARY TRAINING AT HISTORICALLY BLACK COLLEGES IN THE JIM CROW SOUTH INTRODUCTION SO SEGREGATED SOLDIERS: MILITARY TRAINING AT HISTORICALLY BLACK COLLEGES IN THE JIM CROW SOUTH LA English DT Editorial Material; Book Chapter C1 US Army, Adelphi, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LOUISIANA STATE UNIV PRESS PI BATON ROUGE PA BATON ROUGE, LA 70803 USA BN 978-0-8071-5177-8; 978-0-8071-5176-1 PY 2013 BP 1 EP + PG 10 WC History SC History GA BA0GE UT WOS:000331137900003 ER EF