FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Divers, SJ
Boone, SS
Berliner, A
Kurimo, EA
Boysen, KA
Johnson, DR
Killgore, KJ
George, SG
Hoover, JJ
AF Divers, Stephen J.
Boone, Shaun S.
Berliner, Aimee
Kurimo, Elizabeth A.
Boysen, Krista A.
Johnson, David R.
Killgore, K. Jack
George, Steven G.
Hoover, Jan Jeffrey
TI NONLETHAL ACQUISITION OF LARGE LIVER SAMPLES FROM FREE-RANGING RIVER
STURGEON (SCAPHIRHYNCHUS) USING SINGLE-ENTRY ENDOSCOPIC BIOPSY FORCEPS
SO JOURNAL OF WILDLIFE DISEASES
LA English
DT Article
DE Disease diagnosis; endoscopy; fish; liver biopsy; pathology;
Scaphirhynchus; sturgeon; toxicology
ID FLOWING MISSISSIPPI RIVER; AFRICAN ATLANTIC-OCEAN; PALLID STURGEON;
WHITE STURGEON; POLYCHLORINATED-BIPHENYLS; SHOVELNOSE STURGEON; WATER
FISH; SHARK; ACIPENSER; GROWTH
AB Harvesting of liver samples for toxicologic and other laboratory analyses is frequently undertaken in free-ranging fish to evaluate accumulations of various pollutants and chemicals. However, commonly used, lethal techniques for collecting liver tissues are unacceptable when dealing with protected species. We report the use of a nonlethal, single-entry, endoscopic technique using saline infusion to examine and collect large liver samples using optical biopsy forceps from 16 free-ranging sturgeon (Scaphirhynchus spp.) during 25 and 27 January 2010. Under tricaine methanesulfonate anesthesia and following the introduction of the optical biopsy forceps (with a 5-mm telescope) through a 1-2-cm ventral midline skin incision, liver examination and collection of biopsies averaging 0.9 g, ranging up to 1.4 g, and representing up to 12% of total liver tissue were successful. All fish made uneventful recoveries and necropsy examinations the following day failed to indicate any significant hemorrhage or iatrogenic trauma. We recommend the use of large optical biopsy forceps as a practical, nonlethal alternative for collection of large liver biopsies from sturgeon and other fish.
C1 [Divers, Stephen J.; Boone, Shaun S.; Kurimo, Elizabeth A.] Univ Georgia, Coll Vet Med, Dept Small Anim Med & Surg Zool Med, Athens, GA 30602 USA.
[Berliner, Aimee] Georgia Aquarium, Atlanta, GA 30313 USA.
[Boysen, Krista A.] St Louis Univ, Dept Biol, St Louis, MO 63103 USA.
[Johnson, David R.; Killgore, K. Jack; George, Steven G.; Hoover, Jan Jeffrey] USA, Engineer Res & Dev Ctr, Waterways Expt Stn, Vicksburg, MS 39180 USA.
RP Divers, SJ (reprint author), Univ Georgia, Coll Vet Med, Dept Small Anim Med & Surg Zool Med, Athens, GA 30602 USA.
EM sdivers@uga.edu
FU Dredging Operations and Environmental Research program
FX This project was funded by the Dredging Operations and Environmental
Research program. We are grateful to Christopher Chamness and Karl Storz
Endoscopy for building the prototype optical biopsy forceps, and
supporting endoscopy research and development at the University of
Georgia's College of Veterinary Medicine. Assistance in the field was
provided by Jay Collins, Neil Douglas, Kathie Eagles, Nick Friedenberg,
Audrey Harrison, Phil Kirk, Bradley Lewis, Thomas Parker, and Todd
Slack. Pectoral rays were processed and read by Bradley Lewis and Todd
Slack. Site access, working area, electricity, running water, and
home-cooked meals were provided by Wanda Landner and her team from Fort
Adams, Mississippi. Permission to publish was granted by the US Army
Chief of Engineers.
NR 41
TC 1
Z9 1
U1 3
U2 14
PU WILDLIFE DISEASE ASSOC, INC
PI LAWRENCE
PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 USA
SN 0090-3558
J9 J WILDLIFE DIS
JI J. Wildl. Dis.
PD APR
PY 2013
VL 49
IS 2
BP 321
EP 331
DI 10.7589/2012-07-203
PG 11
WC Veterinary Sciences
SC Veterinary Sciences
GA 128YP
UT WOS:000317805900012
PM 23568907
ER
PT J
AU Wolfenstine, J
Jo, H
Cho, YH
David, IN
Askeland, P
Case, ED
Kim, H
Choe, H
Sakamoto, J
AF Wolfenstine, Jeff
Jo, Hyungyung
Cho, Yong-Hun
David, Isabel N.
Askeland, Per
Case, Eldon D.
Kim, Hyunjoong
Choe, Heeman
Sakamoto, Jeff
TI A preliminary investigation of fracture toughness of Li7La3Zr2O12 and
its comparison to other solid Li-ion conductors
SO MATERIALS LETTERS
LA English
DT Article
DE Batteries; Solid state electrolyte
ID MECHANICAL-PROPERTIES; INDENTATION METHOD; GRAIN-SIZE; GARNET; CERAMICS;
DEPENDENCE; CRACKING; ALUMINA; ENERGY
AB This is the first report of fracture toughness analysis of a new ceramic electrolyte (Li7La3Zr2O12). The fracture toughness was measured using an indentation technique and subsurface crack propagation was analyzed using a novel focused ion beam/scanning electron microscope (FIB-SEM) technique. The fracture toughness of polycrystalline Li7La3Zr2O12 was between 0.86-1.63 MPa root m. FIB-SEM analysis of the indentation cracks suggested that both half-penny and Palmquist cracks were present. The fracture toughness of Li7La3Zr2O12 is comparable to other state of the art ceramic electrolytes such as Li0.33La0.57TiO3 and Li1.3Al0.3Ti1.7(PO4)(3). (C) 2013 Elsevier B.V. All rights reserved.
C1 [Wolfenstine, Jeff] USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA.
[Jo, Hyungyung; Cho, Yong-Hun; Choe, Heeman] Kookmin Univ, Sch Adv Mat Engn, Seoul 136702, South Korea.
[David, Isabel N.; Askeland, Per; Case, Eldon D.; Kim, Hyunjoong; Sakamoto, Jeff] Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA.
RP Sakamoto, J (reprint author), Michigan State Univ, Dept Chem Engn & Mat Sci, 2527 Michigan State Univ, E Lansing, MI 48824 USA.
EM jsakamot@msu.edu
RI Choe, Heeman/J-4053-2013
OI Choe, Heeman/0000-0002-5908-577X
FU US Army Research Laboratory (ARL); Basic Science Research Program
[2010-0005775]; Pioneer Research Center Program [2011-0001684]; Priority
Research Centers Program [2009-0093814]; National Research Foundation of
Korea (NRF); Ministry of Education, Science and Technology
FX JW and JS would like to acknowledge the support of the US Army Research
Laboratory (ARL). HC also acknowledges supports from the Basic Science
Research Program (2010-0005775), the Pioneer Research Center Program
(2011-0001684), and the Priority Research Centers Program (2009-0093814)
through the National Research Foundation of Korea (NRF) funded by the
Ministry of Education, Science and Technology.
NR 28
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Z9 9
U1 4
U2 84
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-577X
J9 MATER LETT
JI Mater. Lett.
PD APR 1
PY 2013
VL 96
BP 117
EP 120
DI 10.1016/j.matlet.2013.01.021
PG 4
WC Materials Science, Multidisciplinary; Physics, Applied
SC Materials Science; Physics
GA 127LT
UT WOS:000317701200030
ER
PT J
AU Clayton, JD
AF Clayton, J. D.
TI Mesoscale modeling of dynamic compression of boron carbide polycrystals
SO MECHANICS RESEARCH COMMUNICATIONS
LA English
DT Article
DE Finite strain; Intrinsic stability; Shock compression; Ceramic crystal;
Numerical simulation
ID NONLINEAR ELASTICITY; RELATIVE STRENGTHS; STABILITY-CRITERIA;
PLASTICITY; PRESSURE; FRACTURE; DAMAGE; TEMPERATURE; INSTABILITY;
CONSTANTS
AB An anisotropic nonlinear elastic model is advanced for crystals belonging to either of two polytypes of boron carbide ceramic. Crystals undergo transformation to an isotropic, amorphous phase upon attainment of a local state-based criterion associated with a loss of intrinsic stability. The model is implemented using the dynamic finite element method, and is demonstrated on a representative volume consisting of fifty polyhedral grains subjected to uniaxial strain at a uniform high strain rate and shock compression at axial pressures ranging from 10 to 50 GPa. Predicted stress-strain behavior is in close agreement with experimental data. For polycrystals consisting of both polytypes, amorphization initiates at stress levels slightly below the experimental Hugoniot elastic limit, and occurs more readily than observed in experiment. For polycrystals consisting only of the CBC (polar) polytype, amorphization initiates at impact pressures similar to those suggested by experiment. In either case, transformation is promoted by dynamic stress interactions and elastic coefficient mismatch among anisotropic crystals. Results support a previous conjecture that amorphization is related to shear instability and cross-linking of the CBC chain in the polar polytype. Published by Elsevier Ltd.
C1 USA, RDRL WMP C, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Clayton, JD (reprint author), USA, RDRL WMP C, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM john.d.clayton1.civ@mail.mil
RI Clayton, John/C-7760-2009
NR 43
TC 5
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U1 0
U2 16
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0093-6413
J9 MECH RES COMMUN
JI Mech. Res. Commun.
PD APR
PY 2013
VL 49
BP 57
EP 64
DI 10.1016/j.mechrescom.2013.02.005
PG 8
WC Mechanics
SC Mechanics
GA 129AR
UT WOS:000317811300009
ER
PT J
AU Casey, DP
Curry, TB
Charkoudian, N
Joyner, MJ
Hart, EC
AF Casey, Darren P.
Curry, Timothy B.
Charkoudian, Nisha
Joyner, Michael J.
Hart, Emma C.
TI The Effects of Acute Beta-Adrenergic Blockade on Aortic Wave Reflection
in Postmenopausal Women
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Article
DE aortic wave reflection; beta-adrenergic receptors; blood pressure;
hypertension; menopause
ID CENTRAL BLOOD-PRESSURE; ISOLATED SYSTOLIC HYPERTENSION; ARTERIAL
STIFFNESS; AUGMENTATION INDEX; HEART-RATE; ATENOLOL; NEBIVOLOL;
BLOCKERS; HUMANS; FORM
AB BACKGROUND
Acute beta-adrenergic blockade increases aortic-wave reflection in young women. However, it is not known whether this effect extends to postmenopausal women. We therefore examined the effect of systemic beta-adrenergic blockade on aortic wave reflection in 14 postmenopausal women with a mean age of 58 +/- 2 years.
METHODS
Aortic pressure waveforms were synthesized noninvasively from high-fidelity radial pressure waveforms obtained through applanation tonometry before and during systemic beta-blockade with propranolol given in a bolus dose of 0.25 mg/kg, followed by a continuous infusion at 0.004 mg/kg/min. To further examine the effects of acute beta-blockade on aortic-wave reflection in postmenopausal women, we compared the changes in hemodynamics and indices of aortic-wave reflection with published data from a previous study with a protocol identical to that in the present study but which involved young women.
RESULTS
Acute beta-blockade increased the aortic augmentation index (AI(x)) in postmenopausal women (32 +/- 2% vs. 35 +/- 2%, P < 0.01). However, AI(x) adjusted for a heart rate of 75 bpm (AI(x)75) was unchanged (25 +/- 2% vs. 24 +/- 2%, P > 0.05). The changes in AI(x), AI(x)75, and the amplitude of reflected waves (augmented aortic pressure) during beta-blockade were all substantially smaller in postmenopausal women than in their younger counterparts (P < 0.05).
CONCLUSIONS
As compared with those in our previously published study involving young women, indices of aortic-wave reflection were significantly less affected by acute systemic beta-adrenergic blockade in the postmenopausal women in the present study. Taken together, our data suggest that the negative effects (i.e. increased aortic wave reflection) of nonselective beta-adrenergic blockade are less pronounced in postmenopausal than in young women.
C1 [Casey, Darren P.; Curry, Timothy B.; Joyner, Michael J.] Mayo Clin, Dept Anesthesiol, Rochester, MN 55905 USA.
[Casey, Darren P.] Mayo Clin, Dept Physiol & Biomed Engn, Rochester, MN USA.
[Charkoudian, Nisha] USA, Environm Med Res Inst, Natick, MA 01760 USA.
[Hart, Emma C.] Univ Bristol, Sch Physiol & Pharmacol, Bristol, Avon, England.
RP Casey, DP (reprint author), Mayo Clin, Dept Anesthesiol, Rochester, MN 55905 USA.
EM casey.darren@mayo.edu
OI Hart, Emma/0000-0002-4534-9586
FU National Institutes of Health (Mayo Clinic) [HL083947, HL46493, AR55819,
DK082424, CTSA RR-024150]; Mayo Clinic Research Subcommittee Early
Career Development Supplement; American Heart Association [2170087]
FX The authors are grateful to the study volunteers for their
participation. They also thank Shelly Roberts, Jean Knutson, Karen
Krucker, Christopher Johnson, Nancy Meyer, and Pam Engrav for their
technical assistance. This study was supported by National Institutes of
Health grants HL083947, HL46493, AR55819, DK082424, and CTSA RR-024150
(Mayo Clinic), by a Mayo Clinic Research Subcommittee Early Career
Development Supplement, and by American Heart Association grant 2170087
(ECH).
NR 38
TC 2
Z9 2
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0895-7061
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD APR
PY 2013
VL 26
IS 4
BP 503
EP 510
DI 10.1093/ajh/hps074
PG 8
WC Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 122LP
UT WOS:000317319900008
PM 23467206
ER
PT J
AU Labare, MP
Soohoo, H
Kim, D
Tsoi, KY
Liotta, JL
Bowman, DD
AF Labare, Michael P.
Soohoo, Hilary
Kim, Dong
Tsoi, Key Yan
Liotta, Janice L.
Bowman, Dwight D.
TI Ineffectiveness of a quaternary ammonium salt and povidone-iodine for
the inactivation of Ascaris suum eggs
SO AMERICAN JOURNAL OF INFECTION CONTROL
LA English
DT Article
DE Ascaris; Iodine; Disinfectant; Quaternary ammonium salt
ID LUMBRICOIDES; SLUDGE; OVA
AB Two commonly used disinfectants, a quaternary ammonium salt and povidone-iodine, were tested for effectiveness against unembryonated Ascaris suum eggs. The quaternary ammonium salt (alkyl dimethyl benzyl ammonium chloride) had no effect on the Ascaris eggs (10 minutes and 22 degrees C) when compared with the controls in water with egg viabilities of 88.8% +/- 3.3% and 86.9% +/- 6.2%, respectively. An additional quaternary ammonium salt, 2.5% benzethonium chloride, also had no effect. Phenol (5%) and cresol (3%) completely inactivated the eggs. Povidone-iodine at 100%, 50%, 10%, and 1% had no effect on the eggs at exposures of 5, 15, 30, 60, or 120 minutes (22 degrees C) compared with the water controls. Published by Elsevier Inc. on behalf of Association for Professionals in Infection Control and Epidemiology, Inc.
C1 [Labare, Michael P.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA.
[Soohoo, Hilary; Kim, Dong; Tsoi, Key Yan; Liotta, Janice L.; Bowman, Dwight D.] Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Ithaca, NY 14853 USA.
RP Labare, MP (reprint author), US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA.
EM michael.labare@usma.edu
NR 10
TC 5
Z9 5
U1 1
U2 16
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0196-6553
J9 AM J INFECT CONTROL
JI Am. J. Infect. Control
PD APR
PY 2013
VL 41
IS 4
BP 360
EP 361
DI 10.1016/j.ajic.2012.05.013
PG 2
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 123UG
UT WOS:000317416000017
PM 23102984
ER
PT J
AU Biberoglu, K
Schopfer, LM
Saxena, A
Tacal, O
Lockridge, O
AF Biberoglu, Kevser
Schopfer, Lawrence M.
Saxena, Ashima
Tacal, Ozden
Lockridge, Oksana
TI Polyproline tetramer organizing peptides in fetal bovine serum
acetylcholinesterase
SO BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
LA English
DT Article
DE Fetal bovine serum acetylcholinesterase; Polyproline peptide; Mass
spectrometry; PAGE gel electrophoresis; Tetramer organization
ID TANDEM MASS-SPECTROMETRY; PROLINE-RICH PEPTIDES; QUATERNARY
ASSOCIATIONS; ATTACHMENT DOMAIN; MEMBRANE ANCHOR; COLLAGEN TAIL;
GAS-PHASE; BUTYRYLCHOLINESTERASE; FRAGMENTATIONS; PURIFICATION
AB Acetylcholinesterase (AChE) in the serum of fetal cow is a tetramer. The related enzyme, butyrylcholinesterase (BChE), in the sera of humans and horse requires polyproline peptides for assembly into tetramers. Our goal was to determine whether soluble tetrameric AChE includes tetramer organizing peptides in, its structure. Fetal bovine serum AChE was denatured by boiling to release non-covalently bound peptides. Bulk protein was separated from peptides by filtration and by high performance liquid chromatography. Peptide mass and amino acid sequence of the released peptides were determined by MALDI-TOF-TOF and LTQ-Orbitrap mass spectrometry. Twenty polyproline peptides, divided into 5 families, were identified. The longest peptide contained 25 consecutive prolines and no other amino acid. Other polyproline peptides included one non-proline amino acid, for example serine at the C-terminus of 20 prolines. A search of the mammalian proteome database suggested that this assortment of polyproline peptides originated from at least 5 different precursor proteins, none of which were the ColQ or PRiMA of membrane-anchored AChE. To date, AChE and BChE are the only proteins known that include polyproline tetramer organizing peptides in their tetrameric structure. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Biberoglu, Kevser; Tacal, Ozden] Hacettepe Univ, Sch Pharm, Dept Biochem, TR-06100 Ankara, Turkey.
[Schopfer, Lawrence M.; Lockridge, Oksana] Univ Nebraska Med Ctr, Eppley Inst, Omaha, NE 68198 USA.
[Saxena, Ashima] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
RP Schopfer, LM (reprint author), Univ Nebraska Med Ctr, Eppley Inst, Omaha, NE 68198 USA.
EM Kevser.biberoglu@gmail.com; lmschopf@unmc.edu;
ashima.saxena@us.army.mil; otacal@yahoo.com; olockrid@unmc.edu
FU TUBITAK grant from the Scientific and Technological Research Council of
Turkey; Hacettepe University; NIH [P30CA36727]
FX This work was supported by a TUBITAK grant from the Scientific and
Technological Research Council of Turkey to OT, a fellowship from
Hacettepe University to KB, and NIH grant P30CA36727 to the Eppley
Cancer Center.
NR 30
TC 5
Z9 5
U1 0
U2 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1570-9639
J9 BBA-PROTEINS PROTEOM
JI BBA-Proteins Proteomics
PD APR
PY 2013
VL 1834
IS 4
BP 745
EP 753
DI 10.1016/j.bbapap.2013.01.009
PG 9
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA 124GR
UT WOS:000317452300004
PM 23352838
ER
PT J
AU Doty, TJ
Japee, S
Ingvar, M
Ungerleider, LG
AF Doty, Tracy J.
Japee, Shruti
Ingvar, Martin
Ungerleider, Leslie G.
TI Fearful Face Detection Sensitivity in Healthy Adults Correlates With
Anxiety-Related Traits
SO EMOTION
LA English
DT Article
DE intersubject variability; masked fearful faces; state anxiety;
neuroticism; harm avoidance
ID FACIAL EXPRESSIONS; VISUAL AWARENESS; SOCIAL ANXIETY; ANGRY FACES;
EMOTION; ATTENTION; BIAS; PERSONALITY; DISORDERS; AMYGDALA
AB Threatening faces have a privileged status in the brain, which can be reflected in a processing advantage. However, this effect varies among individuals, even healthy adults. For example, one recent study showed that fearful face detection sensitivity correlated with trait anxiety in healthy adults (S. Japee, L. Crocker, F. Carver, L. Pessoa, & L. G. Ungerleider, 2009. Individual differences in valence modulation of face-selective M170 response. Emotion, 9, 59-69). Here, we expanded on those findings by investigating whether intersubject variability in fearful face detection is also associated with state anxiety, as well as more broadly with other traits related to anxiety. To measure fearful face detection sensitivity, we used a masked face paradigm where the target face was presented for only 33 ms and was immediately followed by a neutral face mask. Subjects then rated their confidence in detecting either fear or no fear in the target face. Fearful face detection sensitivity was calculated for each subject using signal detection theory. Replicating previous results, we found a significant positive correlation between trait anxiety and fearful face detection sensitivity. However, this behavioral advantage did not correlate with state anxiety. We also found that fearful face detection sensitivity correlated with other personality measures, including neuroticism and harm avoidance. Our data suggest that fearful face detection sensitivity varies parametrically across the healthy population, is associated broadly with personality traits related to anxiety, but remains largely unaffected by situational fluctuations in anxiety. These results underscore the important contribution of anxiety-related personality traits to threat processing in healthy adults.
C1 [Doty, Tracy J.; Japee, Shruti; Ungerleider, Leslie G.] NIMH, Lab Brain & Cognit, Bethesda, MD 20892 USA.
[Doty, Tracy J.; Ingvar, Martin] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
RP Doty, TJ (reprint author), USA, Res Lab, Translat Neurosci Branch, 459 Mulberry Point Rd, Aberdeen, MD 21005 USA.
EM tracy.doty@alumni.duke.edu
RI Doty, Tracy Jill/J-3962-2012;
OI Doty, Tracy/0000-0001-9921-2457; Ingvar, Martin/0000-0002-9041-5714
FU Intramural NIH HHS [Z99 MH999999]
NR 34
TC 10
Z9 10
U1 4
U2 23
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 1528-3542
J9 EMOTION
JI Emotion
PD APR
PY 2013
VL 13
IS 2
BP 183
EP 188
DI 10.1037/a0031373
PG 6
WC Psychology, Experimental
SC Psychology
GA 125FI
UT WOS:000317524600002
PM 23398584
ER
PT J
AU Rafuse, ES
AF Rafuse, Ethan S.
TI The Leadership of Ulysses S. Grant:A General Who Will Fight
SO JOURNAL OF MILITARY HISTORY
LA English
DT Book Review
C1 [Rafuse, Ethan S.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA.
RP Rafuse, ES (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 2
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
J9 J MILITARY HIST
JI J. Mil. Hist.
PD APR
PY 2013
VL 77
IS 2
BP 706
EP 707
PG 2
WC History
SC History
GA 120GN
UT WOS:000317158900033
ER
PT J
AU Bourque, SA
AF Bourque, Stephen A.
TI The Blood of Free Men: The Liberation of Paris, 1944
SO JOURNAL OF MILITARY HISTORY
LA English
DT Book Review
C1 [Bourque, Stephen A.] Sch Adv Mil Studies, Ft Leavenworth, KS 66027 USA.
RP Bourque, SA (reprint author), Sch Adv Mil Studies, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
J9 J MILITARY HIST
JI J. Mil. Hist.
PD APR
PY 2013
VL 77
IS 2
BP 747
EP 749
PG 3
WC History
SC History
GA 120GN
UT WOS:000317158900062
ER
PT J
AU House, JM
AF House, Jonathan M.
TI State of War: The Political Economy of American Warfare, 1945-2011
SO JOURNAL OF MILITARY HISTORY
LA English
DT Book Review
C1 [House, Jonathan M.] US Army Command, Ft Leavenworth, KS 66027 USA.
[House, Jonathan M.] Gen Staff Coll, Ft Leavenworth, KS USA.
RP House, JM (reprint author), US Army Command, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
J9 J MILITARY HIST
JI J. Mil. Hist.
PD APR
PY 2013
VL 77
IS 2
BP 753
EP 754
PG 2
WC History
SC History
GA 120GN
UT WOS:000317158900066
ER
PT J
AU Grau, LW
AF Grau, Lester W.
TI War from the Ground Up: Twenty-First Century Combat as Politics
SO JOURNAL OF MILITARY HISTORY
LA English
DT Book Review
C1 [Grau, Lester W.] Foreign Mil Studies Off, Ft Leavenworth, KS 66027 USA.
RP Grau, LW (reprint author), Foreign Mil Studies Off, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
J9 J MILITARY HIST
JI J. Mil. Hist.
PD APR
PY 2013
VL 77
IS 2
BP 768
EP 769
PG 2
WC History
SC History
GA 120GN
UT WOS:000317158900076
ER
PT J
AU Huber, T
AF Huber, Thomas
TI We are always pleased to have letters to the editor because this shows
that people are reading our Journal seriously. However, due to space
limitations, we ask that letters be kept under 500 words
SO JOURNAL OF MILITARY HISTORY
LA English
DT Letter
C1 Gen Staff & Command Coll, Mil Hist Dept, Ft Leavenworth, KS 66027 USA.
RP Huber, T (reprint author), Gen Staff & Command Coll, Mil Hist Dept, Ft Leavenworth, KS 66027 USA.
NR 2
TC 0
Z9 0
U1 0
U2 0
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
J9 J MILITARY HIST
JI J. Mil. Hist.
PD APR
PY 2013
VL 77
IS 2
BP 790
EP 792
PG 3
WC History
SC History
GA 120GN
UT WOS:000317158900082
ER
PT J
AU Maule, AL
Heaton, KJ
Rodrigues, E
Smith, KW
McClean, MD
Proctor, SP
AF Maule, Alexis L.
Heaton, Kristin J.
Rodrigues, Ema
Smith, Kristen W.
McClean, Michael D.
Proctor, Susan P.
TI Postural Sway and Exposure to Jet Propulsion Fuel 8 Among US Air Force
Personnel
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
ID CLINICAL BALANCE TESTS; TRUNK SWAY; INHALATION EXPOSURE; URINARY
BIOMARKERS; SOLVENT EXPOSURE; DERMAL EXPOSURE; WORKERS; JP-8; STABILITY;
GAIT
AB Objective: To determine whether short-term jet propulsion fuel 8 (JP-8) exposure is associated with balance measurements in JP-8-exposed air force personnel. Methods: As part of a larger neuroepidemiology study, balance tasks were completed by JP-8 exposed individuals (n = 37). Short-term JP-8 exposure was measured using personal breathing zone levels and urinary biomarkers. Multivariate linear regression analyses were conducted to examine the relationship between workday JP-8 exposure and postural sway. Results: Balance control decreased as the task became more challenging. Workday exposure to JP-8, measured by either personal air or urinary metabolite levels, was not significantly related to postural sway. Increases in workday postural sway were associated with demographic variables, including younger age, being a current smoker, and higher body mass index. Conclusion: Results suggest that short-term workday JP-8 exposure does not significantly contribute to diminished balance control.
C1 [Maule, Alexis L.; Heaton, Kristin J.; Proctor, Susan P.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA.
[Heaton, Kristin J.; Proctor, Susan P.] USA, Environm Med Res Inst, Natick, MA 01760 USA.
[Rodrigues, Ema; Smith, Kristen W.; McClean, Michael D.] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA.
[Proctor, Susan P.] VA Boston Healthcare Syst, Boston, MA USA.
RP Proctor, SP (reprint author), USA, Mil Performance Div, Environm Med Res Inst, Kansas St,Bldg 42, Natick, MA 01760 USA.
EM susan.proctor@us.army.mil
RI sebastianovitsch, stepan/G-8507-2013; Heaton, Kristin/E-3660-2013;
McClean, Michael/J-2934-2015;
OI McClean, Michael/0000-0002-3902-8823
FU US Air Force; US Army Medical Research and Materiel Command/Neurotoxin
Exposure Treatment Program [W81XWH-06-1-0105]
FX The authors thank the US Air Force personnel for their support and
generous participation in the project. They thank the additional Boston
area study team personnel (N. Longcore, E. Kryskow, K. Merchant-Borna,
H. MacDonald, and A. Graefe) and other personnel from local universities
for their assistance in data collection at the respective US Air Force
base locations. This work was supported by the US Army Medical Research
and Materiel Command/Neurotoxin Exposure Treatment Program though a
grant award (W81XWH-06-1-0105; principal investigator: S.P. Proctor) to
the Henry M. Jackson Foundation for the Advancement of Military
Medicine, Inc.
NR 34
TC 3
Z9 3
U1 1
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1076-2752
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD APR
PY 2013
VL 55
IS 4
BP 446
EP 453
DI 10.1097/JOM.0b013e31827db94b
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 124BT
UT WOS:000317439500011
PM 23532195
ER
PT J
AU Cheppudira, B
Greer, A
Mares, A
Fowler, M
Garza, T
Petz, L
Loyd, D
Clifford, J
AF Cheppudira, B.
Greer, A.
Mares, A.
Fowler, M.
Garza, T.
Petz, L.
Loyd, D.
Clifford, J.
TI The anti-inflammatory and analgesic activity of curcumin in a rat model
of full thickness thermal injury
SO JOURNAL OF PAIN
LA English
DT Meeting Abstract
C1 [Cheppudira, B.; Greer, A.; Mares, A.; Fowler, M.; Garza, T.; Petz, L.; Loyd, D.; Clifford, J.] USA, Inst Surg Res, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 1
U2 4
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1526-5900
J9 J PAIN
JI J. Pain
PD APR
PY 2013
VL 14
IS 4
SU 1
BP S52
EP S52
PG 1
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 126RR
UT WOS:000317639400207
ER
PT J
AU Salas, M
Hayden, J
Petz, L
Loyd, D
Slater, T
Clifford, J
Fowler, M
AF Salas, M.
Hayden, J.
Petz, L.
Loyd, D.
Slater, T.
Clifford, J.
Fowler, M.
TI Resiniferatoxin attenuates pain behaviors in a rat model of mixed
thickness thermal injury
SO JOURNAL OF PAIN
LA English
DT Meeting Abstract
C1 [Salas, M.; Hayden, J.; Petz, L.; Loyd, D.; Slater, T.; Clifford, J.; Fowler, M.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1526-5900
J9 J PAIN
JI J. Pain
PD APR
PY 2013
VL 14
IS 4
SU 1
BP S49
EP S49
PG 1
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 126RR
UT WOS:000317639400194
ER
PT J
AU Samokhvalov, IM
Tyniankin, NA
Reva, VA
Rasmussen, TE
AF Samokhvalov, Igor M.
Tyniankin, Nikolay A.
Reva, Viktor A.
Rasmussen, Todd E.
TI The military surgical legacy of Vladimir Oppel (1872-1932)
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article
AB Vladimir A. Oppel (1872-1932) was a forefather of military trauma systems. As a surgeon in the Russian Army in World War I, Oppel experienced the challenges and inefficiencies associated with caring for large numbers of combat wounded, the inefficiencies he observed leading to unacceptable morbidity and mortality. As a consequence, Oppel envisioned a coordinated sequence of surgical care on the battlefield and developed the concept of "targeted evacuation." In his work, Oppel was among the first to propose the "right operation for the right patient at the right location at the right time." Central to Oppel's precepts were (1) the forward positioning of surgical care close to the point of injury, (2) the development of a reserve of proficient and deployable military surgeons, and (3) the provision of specialized surgery to optimize survival and reduce morbidity. Oppel's teachings were validated during World War II in the performance of the Soviet casualty evacuation system and in all modern wars modern since. Today, nearly 100 years after the work of Vladimir Oppel, the benefits of a coordinated or "targeted" trauma system, working to optimize survival after trauma, are well recognized around the world. (J Trauma Acute Care Surg. 2013;74: 1178-1181. Copyright (C) 2013 by Lippincott Williams & Wilkins)
C1 [Samokhvalov, Igor M.; Tyniankin, Nikolay A.; Reva, Viktor A.] Russian Mil Med Acad, Russian Dept War Surg, St Petersburg, Russia.
[Rasmussen, Todd E.] USA, Inst Surg Res, San Antonio, TX 78236 USA.
[Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA.
RP Rasmussen, TE (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, San Antonio, TX 78236 USA.
EM todd.rasmussen@amedd.army.mil
RI Reva, Viktor/R-4746-2016; Samokhvalov, Igor/A-1835-2017
OI Reva, Viktor/0000-0001-6705-9849; Samokhvalov, Igor/0000-0003-1398-3467
NR 16
TC 1
Z9 3
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 2163-0755
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD APR
PY 2013
VL 74
IS 4
BP 1178
EP 1181
DI 10.1097/TA.0b013e3182858407
PG 4
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA 123SS
UT WOS:000317411700039
PM 23511163
ER
PT J
AU Fang, W
Hsu, AL
Caudillo, R
Song, Y
Birdwell, AG
Zakar, E
Kalbac, M
Dubey, M
Palacios, T
Dresselhaus, MS
Araujo, PT
Kong, J
AF Fang, Wenjing
Hsu, Allen L.
Caudillo, Roman
Song, Yi
Birdwell, A. Glen
Zakar, Eugene
Kalbac, Martin
Dubey, Madan
Palacios, Tomas
Dresselhaus, Millie S.
Araujo, Paulo T.
Kong, Jing
TI Rapid Identification of Stacking Orientation in Isotopically Labeled
Chemical-Vapor Grown Bilayer Graphene by Raman Spectroscopy
SO NANO LETTERS
LA English
DT Article
DE AB-stacked bilayer graphene; carbon isotope; Raman spectroscopy; growth
mechanism; fluorination
ID FEW-LAYER GRAPHENE; LARGE-AREA; HIGH-QUALITY; FILMS; DEPOSITION; FOILS
AB The growth of large-area bilayer graphene has been of technological importance for graphene electronics. The successful application of graphene bilayers critically relies on the precise control of the stacking orientation, which determines both electronic and vibrational properties of the bilayer system. Toward this goal, an effective characterization method is critically needed to allow researchers to easily distinguish the bilayer stacking orientation (i.e., AB stacked or turbostratic). In this work, we developed such a method to provide facile identification of the stacking orientation by isotope labeling. Raman spectroscopy of these isotopically labeled bilayer samples shows a clear signature associated with AB stacking between layers, enabling rapid differentiation between turbostratic and AB-stacked bilayer regions. Using this method, we were able to characterize the stacking orientation in bilayer graphene grown through Low Pressure Chemical Vapor Deposition (LPCVD) with enclosed Cu foils, achieving almost 70% AB-stacked bilayer graphene. Furthermore, by combining surface sensitive fluorination with such hybrid C-12/C-13 bilayer samples, we are able to identify that the second layer grows underneath the first-grown layer, which is similar to a recently reported observation.
C1 [Fang, Wenjing; Hsu, Allen L.; Song, Yi; Palacios, Tomas; Dresselhaus, Millie S.; Araujo, Paulo T.; Kong, Jing] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA.
[Dresselhaus, Millie S.] MIT, Dept Phys, Cambridge, MA 02139 USA.
[Caudillo, Roman] Intel Corp, Components Res, Hillsboro, OR 97124 USA.
[Birdwell, A. Glen; Zakar, Eugene; Dubey, Madan] USA, Res Lab, Adelphi, MD 20783 USA.
[Kalbac, Martin] Acad Sci Czech Republic, J Heyrovsky Inst Phys Chem, CZ-18223 Prague 8, Czech Republic.
RP Kong, J (reprint author), MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA.
EM ptaraujo@mit.edu; jingkong@mit.edu
RI Kalbac, Martin/F-5129-2014
FU National Science Foundation [NSF DMR 0845358]; Graphene Approaches to
Terahertz Electronics (GATE) Multidisciplinary University Research
Initiative (MURI) of Massachusetts Institute of Technology (MIT)-Harvard
University-Boston University through the Office of Naval Research (ONR);
MSD Focus Center; U.S. Army Research Laboratory (ARL); GACR
[P208/12/1062]; MSMT [LH13022]; [ONR-MURI-N00014-09-1-1063]
FX This work was partially supported by the National Science Foundation
under award number NSF DMR 0845358 and the Graphene Approaches to
Terahertz Electronics (GATE) Multidisciplinary University Research
Initiative (MURI) of Massachusetts Institute of Technology (MIT)-Harvard
University-Boston University through the Office of Naval Research (ONR),
MSD Focus Center, and U.S. Army Research Laboratory (ARL). P.T.A. and
M.S.D. acknowledge ONR-MURI-N00014-09-1-1063. M.K. acknowledges the
support from GACR project P208/12/1062. M.K. acknowledges the support
from GACR project P208/12/1062 and MSMT (LH13022).
NR 42
TC 65
Z9 66
U1 11
U2 156
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1530-6984
J9 NANO LETT
JI Nano Lett.
PD APR
PY 2013
VL 13
IS 4
BP 1541
EP 1548
DI 10.1021/nl304706j
PG 8
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA 125OO
UT WOS:000317549300029
PM 23470052
ER
PT J
AU Dowben, JS
Grant, JS
Froelich, KD
Keltner, NL
AF Dowben, Jonathan S.
Grant, Joan S.
Froelich, Kimberly D.
Keltner, Norman L.
TI Biological Perspectives Hydroxyzine for Anxiety: Another Look at an Old
Drug
SO PERSPECTIVES IN PSYCHIATRIC CARE
LA English
DT Article
DE Hydroxyzine; anxiety
ID GENERALIZED ANXIETY; DISORDER; EFFICACY; PLACEBO
C1 [Dowben, Jonathan S.] Brooke Army Med Ctr, Pediat & Adolescent Behav Hlth Serv, San Antonio, TX USA.
[Grant, Joan S.; Keltner, Norman L.] Univ Alabama Birmingham, Birmingham, AL 35294 USA.
[Froelich, Kimberly D.] Birmingham VA Med Ctr, Patient Care Serv, Birmingham, AL USA.
RP Keltner, NL (reprint author), Univ Alabama Birmingham, Birmingham, AL 35294 USA.
EM nkeltner@uab.edu
OI Grant, Joan/0000-0001-6000-4060
NR 9
TC 4
Z9 4
U1 2
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0031-5990
J9 PERSPECT PSYCHIATR C
JI Perspect. Psychiatr. Care
PD APR
PY 2013
VL 49
IS 2
BP 75
EP 77
DI 10.1111/ppc.12012
PG 3
WC Nursing; Psychiatry
SC Nursing; Psychiatry
GA 122DE
UT WOS:000317295600002
PM 23557449
ER
PT J
AU Joslyn, S
Nemec, L
Savelli, S
AF Joslyn, Susan
Nemec, Lou
Savelli, Sonia
TI The Benefits and Challenges of Predictive Interval Forecasts and
Verification Graphics for End Users
SO WEATHER CLIMATE AND SOCIETY
LA English
DT Article
ID WEATHER FORECASTS; PROBABILITY; UNCERTAINTY
AB Two behavioral experiments tested the use of predictive interval forecasts and verification graphics by nonexpert end users. Most participants were able to use a simple key to understand a predictive interval graphic, showing a bracket to indicate the upper and lower boundary values of the 80% predictive interval for temperature. In the context of a freeze warning task, the predictive interval forecast narrowed user expectations and alerted participants to the possibility of colder temperatures. As a result, participants using predictive intervals took precautionary action more often than did a control group using deterministic forecasts. Moreover, participants easily understood both deterministic and predictive interval verification graphics, based on simple keys, employing them to correctly identify better performing forecast periods. Importantly, participants with the predictive interval were more likely than those with the deterministic forecast to say they would use that forecast type in the future, demonstrating increased trust. Verification graphics also increased trust in both predictive interval and deterministic forecasts when the effects were isolated from familiarity in the second study. These results suggest that forecasts that include an uncertainty estimate might maintain user trust even when the single-value forecast fails to verify, an effect that may be enhanced by explicit verification data.
C1 [Joslyn, Susan; Savelli, Sonia] Univ Washington, Seattle, WA 98195 USA.
[Nemec, Lou] US Mil Acad, West Point, NY 10996 USA.
RP Joslyn, S (reprint author), Univ Washington, Dept Psychol, POB 351525, Seattle, WA 98195 USA.
EM susanj@uw.edu
FU National Science Foundation [1023354]
FX This material is based upon work supported by the National Science
Foundation Grant 1023354.
NR 12
TC 4
Z9 4
U1 2
U2 13
PU AMER METEOROLOGICAL SOC
PI BOSTON
PA 45 BEACON ST, BOSTON, MA 02108-3693 USA
SN 1948-8327
J9 WEATHER CLIM SOC
JI Weather Clim. Soc.
PD APR
PY 2013
VL 5
IS 2
BP 133
EP 147
DI 10.1175/WCAS-D-12-00007.1
PG 15
WC Environmental Studies; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA 125NH
UT WOS:000317546000004
ER
PT J
AU Stanzione, JF
Giangiulio, PA
Sadler, JM
La Scala, JJ
Wool, RP
AF Stanzione, Joseph F., III
Giangiulio, Philip A.
Sadler, Joshua M.
La Scala, John J.
Wool, Richard P.
TI Lignin-Based Bio-Oil Mimic as Biobased Resin for Composite Applications
SO ACS SUSTAINABLE CHEMISTRY & ENGINEERING
LA English
DT Article
DE Lignin; Renewable resources; Vinyl ester resin; Bio-oil; Styrene
replacements/alternatives; Near-IR; TGA; DMA
ID VINYL-ESTER RESINS; LIQUID MOLDING RESINS; INFRARED-SPECTROSCOPY;
THERMAL-DEGRADATION; MODEL COMPOUNDS; CURE KINETICS; CHEMICALS;
ULTRAFILTRATION; FRACTIONATION; VALORIZATION
AB Lignin is an abundant renewable raw material that has the potential to yield valuable bio-oils consisting of aromatic chemicals when strategically depolymerized. In order to determine if lignin-based bio-oils can be utilized in the development of biobased vinyl ester resins without the need of extensive and costly separations, a methacrylated lignin-based bio-oil mimic (MBO) was generated and utilized as a low viscosity vinyl ester resin (30.3 cP at 25 degrees C) and as a reactive diluent in a standard commercial vinyl ester resin. MBO was comprised of phenol, guaiacols, and catechols that were methacrylated by esterification with methacrylic anhydride and a catalytic amount of 4-dimethylaminopyridine. Curing the resin produced hard transparent thermosets that possessed near complete conversion of free radical polymerizable groups as per near-infrared spectroscopy. Temperatures of maximum decomposition rate (>= 400 degrees C) and initial decomposition temperatures (>= 300 degrees C) were measured by means of thermo-gravimetric analysis (TGA). Glass transition temperatures >= 115 degrees C and storage moduli >= 2.5 GPa at 25 degrees C were measured by dynamic mechanical analysis (DMA). Overall, high-performance lignin-based thermosets were synthesized possessing comparable thermo-gravimetric and thermo-mechanical properties to commercial petroleum- and vinyl ester-based thermosets.
C1 [Stanzione, Joseph F., III; Giangiulio, Philip A.; Wool, Richard P.] Univ Delaware, Dept Chem & Biomol Engn, Newark, DE 19716 USA.
[Stanzione, Joseph F., III; Giangiulio, Philip A.; Wool, Richard P.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA.
[Sadler, Joshua M.; La Scala, John J.] USA, Res Lab, RDRL WMM C, Aberdeen Proving Ground, MD 21005 USA.
RP Wool, RP (reprint author), Univ Delaware, Dept Chem & Biomol Engn, Newark, DE 19716 USA.
EM wool@udel.edu
FU Strategic Environmental Research and Development Program [SERDP WP-1758,
W911NF-06-2-001]
FX The authors gratefully acknowledge the Strategic Environmental Research
and Development Program (SERDP WP-1758) through the Cooperative
Agreement W911NF-06-2-001 for financial support. In addition, the
authors thank Dr. Thomas H. Epps and Dr. Michael T. Klein of the
Chemical & Biomolecular Engineering Department at the University of
Delaware for use of his GPC and insightful conversations, respectively.
The authors also thank Dr. Michael Mackay of the Materials Science and
Engineering Department at the University of Delaware for use of his TGA
and DSC.
NR 44
TC 27
Z9 27
U1 2
U2 90
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2168-0485
J9 ACS SUSTAIN CHEM ENG
JI ACS Sustain. Chem. Eng.
PD APR
PY 2013
VL 1
IS 4
BP 419
EP 426
DI 10.1021/sc3001492
PG 8
WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY;
Engineering, Chemical
SC Chemistry; Science & Technology - Other Topics; Engineering
GA 120FN
UT WOS:000317156300006
ER
PT J
AU Theurer, WM
Bhavsar, AK
AF Theurer, Wesley M.
Bhavsar, Amit K.
TI Prevention of Unintentional Childhood Injury
SO AMERICAN FAMILY PHYSICIAN
LA English
DT Article
ID RISK-FACTORS; RESIDENTIAL FIRES; META-REGRESSION; SAFETY; CHILDREN;
HOME; METAANALYSIS; DEATHS; RATES; FALLS
AB Unintentional injury accounts for 40 percent of childhood deaths annually, most commonly from motor vehicle crashes. The proper use of child restraints is the most effective strategy to prevent injury or death. Motor vehicle restraint guidelines have recently been revised to an age-based system that delays the progression in type of restraint for most children. Strategies to prevent suffocation in children include using appropriate bedding, positioning babies on their backs to sleep, and removing items from the sleep and play environment that could potentially entrap or entangle the child. Fencing that isolates a swimming pool from the yard and surrounding area and "touch" adult supervision (i.e., an adult is in the water and able to reach and grab a child) have been shown to be most effective in preventing drownings. Swimming lessons are recommended for children older than four years. Poison prevention programs have been shown to improve prevention behavior among caregivers, but may not decrease poisoning incidence. Syrup of ipecac is not recommended. Smoke detector maintenance, a home escape plan, and educating children about how to respond during a fire emergency are effective strategies for preventing fire injuries or death. Fall injuries may be reduced by not using walkers for infants and toddlers or bunk beds for children six years and younger. Consistent helmet use while bicycling reduces head and brain injuries. Although direct counseling by physicians appears to improve some parental safety behaviors, its effect on reducing childhood injuries is uncertain. Community-based interventions can be effective in high-risk populations. (Am Fam Physician. 2013;87(7):502-509. Copyright (c) 2013 American Academy of Family Physicians.)
C1 [Theurer, Wesley M.] USA, Madigan Army Med Ctr, Tacoma, WA 98431 USA.
[Bhavsar, Amit K.] USA, Tripler Army Med Ctr, Honolulu, HI USA.
RP Theurer, WM (reprint author), USA, Madigan Family Med Bldg,9040 Jackson Ave, Tacoma, WA 98431 USA.
EM wesley.theurer@amedd.army.mil
NR 40
TC 5
Z9 6
U1 2
U2 28
PU AMER ACAD FAMILY PHYSICIANS
PI KANSAS CITY
PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA
SN 0002-838X
J9 AM FAM PHYSICIAN
JI Am. Fam. Physician
PD APR 1
PY 2013
VL 87
IS 7
BP 502
EP 509
PG 8
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA 121QR
UT WOS:000317259800007
PM 23547592
ER
PT J
AU Dumre, SP
Shakya, G
Na-Bangchang, K
Eursitthichai, V
Grams, HR
Upreti, SR
Ghimire, P
Khagendra, KC
Nisalak, A
Gibbons, RV
Fernandez, S
AF Dumre, Shyam P.
Shakya, Geeta
Na-Bangchang, Kesara
Eursitthichai, Veerachai
Grams, Hans Rudi
Upreti, Senendra R.
Ghimire, Prakash
Khagendra, K. C.
Nisalak, Ananda
Gibbons, Robert V.
Fernandez, Stefan
TI Short Report: Dengue Virus and Japanese Encephalitis Virus
Epidemiological Shifts in Nepal: A Case of Opposing Trends
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID IMMUNIZATION; VACCINE; CHILDREN
AB We report on the changing epidemiology of two important flaviviruses in Nepal: Japanese encephalitis (JE) and dengue viruses. Morbidity and mortality in Nepal is in the thousands since JE was introduced in 1978. Nepal launched an extensive laboratory-based JE surveillance in 2004. Nepal experienced a remarkable reduction in disease burden after mass immunizations from 2005 to 2010, when 2,040 JE infections and 205 JE-related deaths were confirmed. With its emergence in 2006, dengue has become a significant challenge in the country, highlighted by a sudden outbreak in 2010 that resulted in 359 confirmed dengue infections. Currently, both viruses cocirculate in Nepal. Here, we document the remarkable expansion of dengue in Nepal, which urgently requires national surveillance to refine the burden and make recommendations regarding control and prevention programs. We believe that the use of existing JE surveillance network for integrated dengue surveillance may represent the most appropriate alternative.
C1 [Dumre, Shyam P.; Na-Bangchang, Kesara; Eursitthichai, Veerachai; Grams, Hans Rudi] Thammasat Univ, Fac Allied Hlth Sci, Pathum Thani, Thailand.
[Shakya, Geeta; Khagendra, K. C.] Minist Hlth & Populat, Natl Publ Hlth Lab, Kathmandu, Nepal.
[Upreti, Senendra R.] Minist Hlth & Populat, Kathmandu, Nepal.
[Ghimire, Prakash] Tribhuwan Univ, Cent Dept Microbiol, Kathmandu, Nepal.
[Nisalak, Ananda; Gibbons, Robert V.; Fernandez, Stefan] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
RP Fernandez, S (reprint author), USAMC AFRIMS, APO, AP 96546 USA.
EM shyamprad@hotmail.com; nphl@wlink.com.np; kesaratmu@yahoo.com;
veebkk@gmail.com; rgrams@alfa.ac.th; senendraupreti933@hotmail.com;
prakashghimire@yahoo.com; khaggu17@hotmail.com; anandan@afrims.org;
robert.gibbons@afrims.org; stefan.fernandez@afrims.org
FU World Health Organization-Special Program for Research and Training in
Topical Diseases, Geneva, Switzerland Leadership Training Grant [A80350]
FX The dengue component of this study was partly supported by World Health
Organization-Special Program for Research and Training in Topical
Diseases, Geneva, Switzerland Leadership Training Grant A80350 (to
S.P.D.).
NR 20
TC 12
Z9 12
U1 0
U2 13
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD APR
PY 2013
VL 88
IS 4
BP 677
EP 680
DI 10.4269/ajtmh.12-0436
PG 4
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 118KP
UT WOS:000317024700012
PM 23419366
ER
PT J
AU Guicheteau, JA
Farrell, ME
Christesen, SD
Fountain, AW
Pellegrino, PM
Emmons, ED
Tripathi, A
Wilcox, P
Emge, D
AF Guicheteau, Jason A.
Farrell, Mikella E.
Christesen, Steven D.
Fountain, Augustus W., III
Pellegrino, Paul M.
Emmons, Erik D.
Tripathi, Ashish
Wilcox, Phillip
Emge, Darren
TI Surface-Enhanced Raman Scattering (SERS) Evaluation Protocol for
Nanometallic Surfaces
SO APPLIED SPECTROSCOPY
LA English
DT Article
DE Surface-enhanced Raman scattering; SERS; Raman; Enhancement factor;
Receiver operator curve
ID SILVER ELECTRODE; LARGE-AREA; SPECTROSCOPY; NANOPARTICLES; PYRIDINE;
SPECTRA; SENSORS; ARRAYS; MODEL
AB We present the results of a three-year collaboration between the U.S. Army Edgewood Chemical Biological Center and the U.S. Army Research Laboratory-Aldelphi Laboratory Center on the evaluation of selected nanometallic surfaces developed for the Defense Advanced Research Projects Agency Surface-Enhanced Raman Scattering (SERS) Science and Technology Fundamentals program. The primary role of the two Army labs was to develop the analytical and spectroscopic figures of merit to unambiguously compare the sensitivity and reproducibility of various SERS substrates submitted by the program participants. We present the design and implementation of an evaluation protocol for SERS active surfaces enabling an enhancement value calculation from which different substrates can be directly compared. This method was established to: (1) collect physical and spectral characterization data from the small number of substrates (performer supplied) typically encountered, and (2) account for the complex fabrication technique and varying nature of the substrate platforms encountered within this program.
C1 [Guicheteau, Jason A.; Christesen, Steven D.; Fountain, Augustus W., III; Wilcox, Phillip; Emge, Darren] Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA.
[Farrell, Mikella E.; Pellegrino, Paul M.] USA, Res Lab, Adelphi Lab Ctr, Adelphi, MD 20783 USA.
[Emmons, Erik D.; Tripathi, Ashish] Sci Applicat Int Corp, Aberdeen Proving Ground, MD 21010 USA.
RP Fountain, AW (reprint author), Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA.
EM augustus.w.fountain.civ@mail.mil
FU DARPA under the SERS S&T Fundamentals program; National Research Council
Research associateship award at the U.S. Army Edgewood Chemical
Biological Center
FX This research was funded by DARPA under the SERS S&T Fundamentals
program. We thank Dennis Polla (DARPA) and Michael Bobrilc (System
Planning Corp.) for support during the Army labs participation as well
as Tracey Hamilton (U.S. Army Medical Research Institute of Chemical
Defense). Finally, we thank all the DARPA participants for providing the
collaborating Army labs with the substrates and information needed to
perform their role in the program. This research was performed while
Erik D. Emmons held a National Research Council Research associateship
award at the U.S. Army Edgewood Chemical Biological Center. The
opinions, interpretations, conclusions, and recommendations are those of
the authors and are not necessarily endorsed by the U.S. Government.
NR 54
TC 9
Z9 9
U1 0
U2 48
PU SOC APPLIED SPECTROSCOPY
PI FREDERICK
PA 5320 SPECTRUM DRIVE SUITE C, FREDERICK, MD 21703 USA
SN 0003-7028
J9 APPL SPECTROSC
JI Appl. Spectrosc.
PD APR
PY 2013
VL 67
IS 4
BP 396
EP 403
DI 10.1366/12-06846
PG 8
WC Instruments & Instrumentation; Spectroscopy
SC Instruments & Instrumentation; Spectroscopy
GA 120KB
UT WOS:000317168100009
PM 23601539
ER
PT J
AU Larue, EA
Zuellig, MP
Netherland, MD
Heilman, MA
Thum, RA
AF LaRue, Elizabeth A.
Zuellig, Matthew P.
Netherland, Michael D.
Heilman, Mark A.
Thum, Ryan A.
TI Hybrid watermilfoil lineages are more invasive and less sensitive to a
commonly used herbicide than their exotic parent (Eurasian watermilfoil)
SO EVOLUTIONARY APPLICATIONS
LA English
DT Article
DE biological invasion; contemporary evolution; herbicide resistance;
heterosis; hybridization; Myriophyllum spicatum
ID HYBRIDIZATION; POPULATIONS; EVOLUTION; HABITATS; PLANTS
AB Hybridization may stimulate the evolution of invasiveness in human-impacted habitats if unique hybrid genotypes have higher fitness than parental genotypes. Human efforts to control invasive taxa frequently involve the intentional alteration of habitats, but few studies have considered whether hybridization can result in decreased sensitivity to control measures. Here, we investigate whether interspecific hybrids between introduced Eurasian watermilfoil (Myriophyllum spicatum) and native northern watermilfoil (M.sibiricum) are more invasive than parental Eurasian watermilfoil, especially in regard to their relative responses to an herbicide commonly applied for their control (2,4-dichlorophenoxyacetic acid; 2,4-D). In two separate laboratory experiments, hybrids on average grew faster and were less sensitive to 2,4-D compared with parental Eurasian watermilfoil. These two invasive traits appear to be common in hybrid watermilfoils, as opposed to being restricted to a few unique lineages, because they were found in a diversity of hybrid genotypes from several independent hybridization events. In addition, we found that hybrids occurred more frequently than parental species in natural lakes previously treated with 2,4-D. Our results provide compelling empirical evidence that hybridization is associated with the evolution of increased invasiveness in watermilfoils, and have important implications for their management.
C1 [LaRue, Elizabeth A.; Zuellig, Matthew P.; Thum, Ryan A.] Grand Valley State Univ, Annis Water Resources Inst, Muskegon, MI 49441 USA.
[Netherland, Michael D.] USA, Ctr Aquat & Invas Plants, Engn Res & Dev Ctr, Gainesville, FL USA.
[Heilman, Mark A.] SePRO Corp, Carmel, IN USA.
RP Larue, EA (reprint author), Grand Valley State Univ, Annis Water Resources Inst, 740 W Shoreline Dr, Muskegon, MI 49441 USA.
EM laruee@mail.gvsu.edu; thumr@gvsu.edu
FU National Science Foundation [DEB-0318553]; We Energies; Michigan Space
Grant Consortium; Midwest Aquatic Plant Management Society; West
Michigan Air and Waste Management Association; Grand Valley State
University
FX Thanks to A. Hruska, D. Wcisel, H. Hayward, and B. Sikkenga for
assistance with sampling and laboratory work. J. McNair provided
statistical advice on the distribution patterns. Discussions with T.
Evans, M. Henshaw, J. Winther, and graduate students at GVSU improved
the study. A. Russell, M. Luttenton, A. Snow, N. MacDonald, and H.
Tavalire provided helpful comments that improved the initial draft of
this manuscript. A. Hendry and two anonymous reviewers greatly improved
the manuscript. Funding for this project was provided by the National
Science Foundation to RAT (DEB-0318553), We Energies, Michigan Space
Grant Consortium, Midwest Aquatic Plant Management Society, West
Michigan Air and Waste Management Association, and Grand Valley State
University.
NR 21
TC 13
Z9 13
U1 6
U2 32
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1752-4571
J9 EVOL APPL
JI Evol. Appl.
PD APR
PY 2013
VL 6
IS 3
BP 462
EP 471
DI 10.1111/eva.12027
PG 10
WC Evolutionary Biology
SC Evolutionary Biology
GA 117MO
UT WOS:000316957800006
PM 23745138
ER
PT J
AU Rodriguez, RI
Ibitayo, D
Quintero, PO
AF Rodriguez, Rogie I.
Ibitayo, Dimeji
Quintero, Pedro O.
TI Thermal Stability Characterization of the Au-Sn Bonding for
High-Temperature Applications
SO IEEE TRANSACTIONS ON COMPONENTS PACKAGING AND MANUFACTURING TECHNOLOGY
LA English
DT Article
DE Fluxless; hermetic packages; isothermal solidification; jet vapor
deposition (JVD); lead-free; shear strength; SLID; solder; transient
liquid phase (TLP) bonding
ID PHASE; TECHNOLOGIES; RELIABILITY; KINETICS; JOINTS
AB There is a need for electromechanical devices capable of operating in high-temperature environments (> 200 degrees C) for a wide variety of applications. Today's wide-bandgap semiconductor-based power electronics have demonstrated a potential of operating above 400 degrees C, however, they are still limited by packaging. Among the most promising alternatives is the Au-Sn eutectic solder, which has been widely used due to its excellent mechanical and thermal properties. However, the operating temperature of this metallurgical system is still limited to similar to 250 degrees C owing to its melting temperature of 280 degrees C. Therefore, a high-temperature-resistant system is much needed, but without affecting the current processing temperature of similar to 325 degrees C, typically exhibited in most high-temperature Pb-free solders. In this paper, we present the development and characterization of a fluxless die-attach soldering process based on gold-enriched solid-liquid interdiffusion (SLID). A low-melting-point material (eutectic Au-Sn) is deposited in the face of a substrate, whereas a high-melting-point material, gold in this instance, is deposited in its mating substrate. Deposition of all materials was performed using a jet vapor deposition (JVD) equipment where thicknesses are controlled to achieve specific compositions in the mixture. Sandwiched coupons are isothermally processed in a vacuum reflow furnace for different reflow times. Postprocessed samples confirm the interdiffusion mechanism as evidenced by the formation of sound joints that prove to be thermally stable up to similar to 490 degrees C after the completion of the SLID process. Differential scanning calorimetry demonstrate the progression of the SLID process by quantifying the remaining low-melting-point constituent as a function of time and temperature, this serving as an indicator of the completion of the soldering process. Mechanical testing reveals a joint with shear strength varying from 39 to 45.5 MPa, demonstrating to be stable even after 500 h of isothermal aging. Moreover, these investigations successfully demonstrate the use of the Au-Sn SLID system and the JVD technology as potential manufacturing processes and as a lead-free die-attach technology.
C1 [Rodriguez, Rogie I.; Quintero, Pedro O.] Univ Puerto Rico, Dept Mech Engn, Mayaguez, PR 00681 USA.
[Ibitayo, Dimeji] USA, Res Lab, Adelphi, MD 20783 USA.
RP Rodriguez, RI (reprint author), Univ Puerto Rico, Dept Mech Engn, Mayaguez, PR 00681 USA.
EM rogie.rodriguez@upr.edu; dimeji.ibitayo@us.army.mil;
pedro.quintero@upr.edu
FU U.S. Army Research Laboratory Collaborative [W911NF-11-2-0062]
FX This work was supported by the U.S. Army Research Laboratory
Collaborative under Agreement W911NF-11-2-0062. Recommended for
publication by Associate Editor M. Bakir upon evaluation of reviewers'
comments.
NR 32
TC 9
Z9 10
U1 5
U2 56
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 2156-3950
J9 IEEE T COMP PACK MAN
JI IEEE Trans. Compon. Pack. Manuf. Technol.
PD APR
PY 2013
VL 3
IS 4
BP 549
EP 557
DI 10.1109/TCPMT.2013.2243205
PG 9
WC Engineering, Manufacturing; Engineering, Electrical & Electronic;
Materials Science, Multidisciplinary
SC Engineering; Materials Science
GA 120RS
UT WOS:000317190200003
ER
PT J
AU Vig, J
Kim, Y
AF Vig, John
Kim, Yoonkee
TI The Low-Power Potential of Oven-Controlled MEMS Oscillators
SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
LA English
DT Article
AB It is shown that oven-controlled micro electromechanical systems (MEMS) oscillators have the potential of attaining a higher frequency stability, with a lower power consumption, than temperature-compensated crystal oscillators (TCXOs) and the currently manufactured MEMS oscillators.
C1 [Kim, Yoonkee] USA, Posit Nav & Timing Branch, CERDEC, Aberdeen, MD USA.
EM j.vig@ieee.org
OI Vig, John/0000-0002-2378-0113
NR 26
TC 5
Z9 5
U1 2
U2 11
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0885-3010
EI 1525-8955
J9 IEEE T ULTRASON FERR
JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control
PD APR
PY 2013
VL 60
IS 4
BP 851
EP 853
DI 10.1109/TUFFC.2013.2634
PG 3
WC Acoustics; Engineering, Electrical & Electronic
SC Acoustics; Engineering
GA 118FU
UT WOS:000317010200022
PM 23549546
ER
PT J
AU Gade, DM
Wilkins, VM
AF Gade, Daniel M.
Wilkins, Vicky M.
TI Where Did You Serve? Veteran Identity, Representative Bureaucracy, and
Vocational Rehabilitation
SO JOURNAL OF PUBLIC ADMINISTRATION RESEARCH AND THEORY
LA English
DT Article
ID ACTIVE REPRESENTATION; SOCIAL IDENTITY; GENDER; COUNSELOR; WAR;
AGENCIES; IMPACT
AB The research on representative bureaucracy investigates whether higher levels of representation within public agencies affect policy outcomes. We expand this line of inquiry by examining the effect of symbolic representation on the clients' perceptions of the vocational rehabilitation program administered by the Department of Veterans Affairs. We test the link between passive representation and symbolic representation for Veteran identity. This is one of the first studies to investigate an identity not associated with immutable characteristics. We question how an identity related to a profession that an individual selects into, like Veteran status, can influence a client's relationship with a government program. We find that Veteran clients of the vocational rehabilitation system perceive substantial differences in the behaviors of their counselor and report significantly higher levels of overall satisfaction with the program when they know or believe their counselor is also a Veteran.
C1 [Gade, Daniel M.] US Mil Acad, Washington, DC USA.
[Wilkins, Vicky M.] Univ Georgia, Athens, GA 30602 USA.
RP Gade, DM (reprint author), US Mil Acad, Washington, DC USA.
EM daniel.gade@usma.edu
NR 47
TC 13
Z9 13
U1 0
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1053-1858
J9 J PUBL ADM RES THEOR
JI J. Publ. Adm. Res. Theory
PD APR
PY 2013
VL 23
IS 2
BP 267
EP 288
DI 10.1093/jopart/mus030
PG 22
WC Public Administration
SC Public Administration
GA 120FB
UT WOS:000317155100003
ER
PT J
AU Carlson, TL
Lee, KW
Pierce, LM
AF Carlson, Terri L.
Lee, Karen W.
Pierce, Lisa M.
TI Effect of Cross-Linked and Non-Cross-Linked Acellular Dermal Matrices on
the Expression of Mediators Involved in Wound Healing and Matrix
Remodeling
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VENTRAL HERNIA REPAIR; ABDOMINAL-WALL RECONSTRUCTION; FOREIGN-BODY
REACTION; MESH MATERIALS; BIOLOGIC PROSTHESES; PORCINE MODEL; RAT MODEL;
METALLOPROTEINASES; INFLAMMATION
AB Background: Molecular mechanisms that direct the extent of the foreign body reaction to implanted biological meshes and their subsequent incorporation are poorly understood. The purpose of this study was to compare the influence of non-cross-linked human dermis (AlloDerm) with that of cross-linked porcine dermis (Permacol) on the expression of genes critical for wound healing and tissue remodeling in a rat ventral hernia model.
Methods: Full-thickness abdominal wall defects were repaired with AlloDerm, Permacol, or suture repair with no mesh (n = 10 rats per group). Explants were harvested 90 days after repair and divided for histologic, immunohistochemical, and gene expression analyses. Real-time quantitative polymerase chain reaction arrays were used to profile the expression of 84 wound healing-associated genes at the tissue/mesh interface.
Results: Both meshes induced the differential expression (>= 3-fold change relative to suture repair, p <= 0.01) of extracellular matrix components, remodeling enzymes, and inflammatory cytokines. Genes most markedly up-regulated included matrix metalloproteinase-9 (Permacol, 66-fold; AlloDerm, 19-fold) and chemokine (C-C motif) ligand 12 (Permacol, 24-fold; AlloDerm, 71-fold). Immunohistochemistry using antibodies against matrix metalloproteinase-9 and chemokine (C-C motif) ligand 12 confirmed differential expression at the protein level (p < 0.001). Histologically, AlloDerm demonstrated overall better remodeling characteristics than Permacol.
Conclusions: Permacol elicits increased protease expression and reduced cellular and vascular infiltration compared with AlloDerm 90 days after implantation, indicative of delayed remodeling induced by cross-linking. Increased understanding of the host response to implanted materials ultimately will enable the development of improved meshes with enhanced wound healing properties and fewer graft-related complications. (Plast. Reconstr. Surg. 131: 697, 2013.)
C1 Tripler Army Med Ctr, Dept Gen Surg, Honolulu, HI 96859 USA.
[Pierce, Lisa M.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA.
RP Pierce, LM (reprint author), Tripler Army Med Ctr, Dept Clin Invest, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM lisa.pierce@amedd.army.mil
FU Victoria S. and Bradley L. Geist Foundation
FX This research was funded by a Victoria S. and Bradley L. Geist
Foundation grant awarded to Lisa M. Pierce, D.Sc.
NR 29
TC 10
Z9 11
U1 1
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0032-1052
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD APR
PY 2013
VL 131
IS 4
BP 697
EP 705
DI 10.1097/PRS.0b013e3182818a3d
PG 9
WC Surgery
SC Surgery
GA 121YW
UT WOS:000317282800047
PM 23249980
ER
PT J
AU Britzke, ER
Gillam, EH
Murray, KL
AF Britzke, E. R.
Gillam, E. H.
Murray, K. L.
TI Current state of understanding of ultrasonic detectors for the study of
bat ecology
SO ACTA THERIOLOGICA
LA English
DT Review
DE Acoustic identification; Bat activity; Echolocation; Sampling design;
Ultrasonic detectors
ID WHITE-NOSE SYNDROME; ECHOLOCATION CALLS; ACOUSTIC IDENTIFICATION;
INDIVIDUAL IDENTITY; LASIURUS-CINEREUS; MYOTIS-LUCIFUGUS; PIPISTRELLE
BATS; FOREST STRUCTURE; BROWN BATS; HABITAT
AB Ultrasonic detectors have become a mainstay for studying the ecology of bats throughout the world. Despite their enormous utility to address a wide variety of research and management issues, many factors that impact the applicability of collected data for answering desired questions are often ignored. Here, we review our current understanding of the utility of ultrasonic detectors for the study of bat ecology and highlight areas where additional work should be done. We gleaned information from published studies, as well as from field research experience, and discuss areas that are in need of further research. We highlight topics such as sampling design and how it can impact results, metrics used to quantify bat activity, and identifying bats with acoustic data including how accuracy rates can be maximized. We also provide research questions that when answered will greatly improve the applicability of future studies.
C1 [Britzke, E. R.] USA, Engineer Res & Dev Ctr, Vicksburg, MS USA.
[Gillam, E. H.] N Dakota State Univ, Dept Biol Sci, Fargo, ND 58105 USA.
[Murray, K. L.] Western EcoSyst Technol Inc, Bloomington, IN USA.
RP Britzke, ER (reprint author), USA, Engineer Res & Dev Ctr, Vicksburg, MS USA.
EM Eric.R.Britzke@usace.army.mil
NR 58
TC 9
Z9 9
U1 12
U2 143
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0001-7051
J9 ACTA THERIOL
JI Acta Theriol.
PD APR
PY 2013
VL 58
IS 2
BP 109
EP 117
DI 10.1007/s13364-013-0131-3
PG 9
WC Zoology
SC Zoology
GA 113PB
UT WOS:000316678900003
ER
PT J
AU Glaz, B
Friedmann, PP
Liu, L
Cajigas, JG
Bain, J
Sankar, LN
AF Glaz, Bryan
Friedmann, Peretz P.
Liu, Li
Cajigas, Juan G.
Bain, Jeremy
Sankar, Lakshmi N.
TI Reduced-Order Dynamic Stall Modeling with Swept Flow Effects Using a
Surrogate-Based Recurrence Framework
SO AIAA JOURNAL
LA English
DT Article
ID VOLTERRA THEORY; SYSTEMS; OPTIMIZATION; PREDICTION; PROGRESS
AB The extension of the surrogate-based recurrence framework approach to account for time-varying swept flow effects under dynamic stall conditions is described. Using full-order solutions generated by the OVERFLOW computational fluid dynamics code, the surrogate-based recurrence framework reduced-order modeling approach is shown to effectively mimic full-order solutions of unsteady lift, moment, and drag under dynamic stall conditions while maintaining the computational efficiency associated with semiempirical dynamic stall models. This level of functionality represents a new capability for rotary-wing aeroelasticity applications. Furthermore, a generalized kriging formulation based on nonstationary Gaussian process modeling is implemented in a tractable manner by locally optimizing the high-dimensional likelihood function in the vicinity of the stationary solution. The resulting nonstationary covariance structures are shown to significantly improve the accuracy of the surrogate-based recurrence framework predicted moment stall characteristics compared to a stationary model. It is shown that the nonstationary surrogate-based recurrence framework approach is better able to adapt to abrupt changes in airload behavior caused by the underlying dynamic stall vortex dynamics. The results indicate that the surrogate-based recurrence framework approach based on nonstationary Gaussian process models is a promising alternative to widely used semiempirical rotorcraft dynamic stall models that cannot account for the effects of time-varying velocity components associated with forward flight.
C1 [Glaz, Bryan] USA, Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Friedmann, Peretz P.] Univ Michigan, Dept Aerosp Engn, Ann Arbor, MI 48109 USA.
[Liu, Li] Univ Michigan, Ann Arbor, MI 48109 USA.
[Cajigas, Juan G.; Bain, Jeremy] Georgia Inst Technol, Atlanta, GA 30332 USA.
[Sankar, Lakshmi N.] Georgia Inst Technol, Daniel Guggenheim Sch Aerosp Engn, Atlanta, GA 30332 USA.
RP Glaz, B (reprint author), USA, Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA.
FU Center for Rotorcraft Innovation [WBS 2010-B-1-431-A17]; Vertical Lift
Research Center of Excellence (VLRCOE); National Rotorcraft Technology
Center (NRTC)
FX Partial support from the Center for Rotorcraft Innovation under no. WBS
2010-B-1-431-A17, as well as the Vertical Lift Research Center of
Excellence (VLRCOE) sponsored by the National Rotorcraft Technology
Center (NRTC) with M. Rutkowski as grant monitor is also acknowledged.
NR 36
TC 4
Z9 6
U1 1
U2 16
PU AMER INST AERONAUT ASTRONAUT
PI RESTON
PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA
SN 0001-1452
J9 AIAA J
JI AIAA J.
PD APR
PY 2013
VL 51
IS 4
BP 910
EP 921
DI 10.2514/1.J051817
PG 12
WC Engineering, Aerospace
SC Engineering
GA 115QP
UT WOS:000316827300013
ER
PT J
AU De Ausen, L
DeFreitas, EF
Littleton, L
Lustik, M
AF De Ausen, Lorena
DeFreitas, Erik F.
Littleton, Latisha
Lustik, Michael
TI Leakage from closed-system transfer devices as detected by a radioactive
tracer
SO AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
LA English
DT Article
ID DRUG TRANSFER DEVICE; SURFACE CONTAMINATION; ANTINEOPLASTIC DRUGS;
WORKPLACE CONTAMINATION; CYCLOPHOSPHAMIDE; EXPOSURE; IFOSFAMIDE; CANCER;
AGENTS; SPILL
AB Purpose. A study of leakage from selected closed-system transfer devices (CSTDs) under experimental conditions is described.
Methods. Three CSTDs (the ChemoClave, On Guard, and PhaSeal systems) were tested. Nine manufacturer-trained oncology pharmacists and pharmacy technicians volunteered to participate in an experiment to determine the degree of leakage of a liquid test agent (a. radioactive technetium isotope [Tc-99m] diluted in normal saline) during CSTD-assisted transfer of liquid from vials to syringes per standard practices. After such transfers, alcohol prep pads (n = 135 for each system) were used to wipe CSTD points of entry and assessed for the presence of Tc-99m. Comparisons among participants and devices were conducted via analysis of variance (ANOVA), with the a priori level of significance set at 0.05.
Results. ANOVA results indicated significant differences among devices in leakage of the test solution, with the PhaSeal device having the lowest geometric mean leakage (0.1 nL; 95% confidence interval [CI], 0-0.2 nL), followed by the OnGuard (1.5 nL;. 95% CI, 1.1-1.9 nL) and ChemoClave (35.6 nL; 95% CI, 29.1-43.6 nL) devices; each pairwise comparison was significant (p < 0.001). Despite several major limitations, the research supports the use of CSTDs to help protect health care workers, as recommended by federal authorities and professional groups including the American Society of Health-System Pharmacists.
Conclusion. The volume of leakage was significantly less with PhaSeal than with OnGuard and ChemoClave when pharmacists and pharmacy technicians used the three CSTDs and Tc-99m as a tracer. Am J Health-Syst Pharm. 2013; 70:619-23
C1 [De Ausen, Lorena; DeFreitas, Erik F.; Littleton, Latisha] Tripler Army Med Ctr, Dept Pharm, Honolulu, HI 96859 USA.
[Littleton, Latisha] 168th Multifunct Med Battal, Taegu, South Korea.
RP DeFreitas, EF (reprint author), 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM erik.defreitas@us.army.mil
FU Department of Pharmacy, Tripler Army Medical Center; Department of
Pharmacy
FX Funded by the Department of Pharmacy, Tripler Army Medical Center. All
devices were purchased using funds from the Department of Pharmacy.
Proprietary information or results of ongoing research may be subject to
different interpretations. Investigators agree to abide by the
noncommercialism guidelines.
NR 20
TC 2
Z9 3
U1 1
U2 5
PU AMER SOC HEALTH-SYSTEM PHARMACISTS
PI BETHESDA
PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 USA
SN 1079-2082
J9 AM J HEALTH-SYST PH
JI Am. J. Health-Syst. Pharm.
PD APR 1
PY 2013
VL 70
IS 7
BP 619
EP 623
DI 10.2146/ajhp110678
PG 5
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 115UP
UT WOS:000316837700015
PM 23515515
ER
PT J
AU Vojta, D
Koehler, TB
Longjohn, M
Lever, JA
Caputo, NF
AF Vojta, Deneen
Koehler, Timothy B.
Longjohn, Matt
Lever, Jonathan A.
Caputo, Nadine F.
TI A Coordinated National Model for Diabetes Prevention Linking Health
Systems to an Evidence-Based Community Program
SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE
LA English
DT Article
ID INTERVENTIONS; REDUCTION; COSTS; US
AB Background: Twenty-six million U.S. adults have diabetes, and 79 million have prediabetes. A2002 Diabetes Prevention Program research study proved the effectiveness of a lifestyle intervention that yielded a 58% reduction in conversion to type 2 diabetes. However, cost per participant was high, complicating efforts to scale up the program.
Purpose: UnitedHealth Group (UHG) and the YMCA of the USA, in collaboration with the CDC, sought to develop the infrastructure and business case to scale the congressionally authorized National Diabetes Prevention Program nationwide. Emphasis was placed on developing a model that maintained fidelity to the original 2002 Diabetes Prevention Program research study and could be deployed for a lower cost per participant while yielding similar outcomes.
Design: The UHG created the business case and technical and operational infrastructure necessary for nationwide dissemination of the YMCA's Diabetes Prevention Program (YMCA's DPP), as part of the National Diabetes Prevention Program. The YMCA's DPP is a group-based model of 16 core sessions with monthly follow-up delivered by trained lifestyle coaches.
Setting/participants: A variety of mechanisms were used to identify, screen, and encourage enrollment for people with prediabetes into the YMCA's DPP.
Intervention: Substantial investments were made in relationship building, business planning, technology, development, and operational design to deliver an effective and affordable 12-month program. The program intervention was conducted July 2010-December 2011. Data were collected on the participants over a 15-month period between September 2010 and December 2011. Data were analyzed in February 2012.
Main outcome measures: The main outcome measures were infrastructure (communities involved and personnel trained); engagement (screening and enrollment of people with prediabetes); program outcomes (attendance and weight loss); and service delivery cost of the intervention.
Results: In less than 2 years, the YMCA's DPP was effectively scaled to 46 communities in 23 states. More than 500 YMCA Lifestyle Coaches were trained. The program enrolled 2369 participants, and 1723 participants completed the core program at an average service-delivery cost of about $400 each. For those individuals completing the program, average weight loss was about 5%. UHG anticipates that within 3 years, savings from reduced medical spending will outweigh initial costs.
Conclusions: Large-scale prevention efforts can be scalable and sustainable with collaboration, health information technology, community-based delivery of evidence-based interventions, and novel payment structures that incentivize efficiency and outcomes linked to better health and lower future costs. (Am J Prev Med 2013;44(4S4):S301-S306) (C) 2013 American Journal of Preventive Medicine
C1 [Vojta, Deneen; Caputo, Nadine F.] United Hlth Grp, UnitedHlth Ctr Hlth Reform & Modernizat, Minnetonka, MN 55343 USA.
[Vojta, Deneen; Koehler, Timothy B.] United Hlth Grp, Diabet Prevent & Control Alliance, Minnetonka, MN USA.
[Longjohn, Matt] USA, Chron Dis Prevent Programs, YMCA, Chicago, IL USA.
[Longjohn, Matt] Northwestern Univ, Dept Pediat, Feinberg Sch Med, Chicago, IL 60611 USA.
[Longjohn, Matt] Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA.
[Lever, Jonathan A.] USA, YMCA, Innovat Dept, Washington, DC 20310 USA.
RP Vojta, D (reprint author), UnitedHlth Grp, Ctr Hlth Reform & Modernizat, 9900 Bren Rd E,MN008-T830, Minnetonka, MN 55343 USA.
EM deneen_vojta@uhg.com
FU CDC, Division of Diabetes Translation
FX Support for this work was provided to the YMCA of the USA by the CDC,
Division of Diabetes Translation. The authors thank Ann Albright, CDC,
for her helpful comments.
NR 20
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PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0749-3797
J9 AM J PREV MED
JI Am. J. Prev. Med.
PD APR
PY 2013
VL 44
IS 4
SU 4
BP S301
EP S306
DI 10.1016/j.amepre.2012.12.018
PG 6
WC Public, Environmental & Occupational Health; Medicine, General &
Internal
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 113NH
UT WOS:000316674200003
PM 23498291
ER
PT J
AU Kirk, H
Myers, PC
Bourke, TL
Gutermuth, RA
Hedden, A
Wilson, GW
AF Kirk, Helen
Myers, Philip C.
Bourke, Tyler L.
Gutermuth, Robert A.
Hedden, Abigail
Wilson, Grant W.
TI FILAMENTARY ACCRETION FLOWS IN THE EMBEDDED SERPENS SOUTH PROTOCLUSTER
SO ASTROPHYSICAL JOURNAL
LA English
DT Article
DE stars: formation; ISM: clouds; ISM: kinematics and dynamics; ISM:
molecules
ID STAR-FORMING CORES; MOLECULAR CLOUDS; DENSE CORES; DARK CLOUDS;
HYPERFINE-STRUCTURE; STELLAR CLUSTERS; PERSEUS; HCN; MM; SPECTROSCOPY
AB One puzzle in understanding how stars form in clusters is the source of mass-is all of the mass in place before the first stars are born, or is there an extended period when the cluster accretes material which can continuously fuel the star formation process? We use a multi-line spectral survey of the southern filament associated with the Serpens South embedded cluster-forming region in order to determine if mass is accreting from the filament onto the cluster, and whether the accretion rate is significant. Our analysis suggests that material is flowing along the filament's long axis at a rate of similar to 30 M-circle dot Myr(-1) (inferred from the N2H+ velocity gradient along the filament), and radially contracting onto the filament at similar to 130 M-circle dot Myr(-1) (inferred from HNC self-absorption). These accretion rates are sufficient to supply mass to the central cluster at a similar rate to the current star formation rate in the cluster. Filamentary accretion flows may therefore be very important in the ongoing evolution of this cluster.
C1 [Kirk, Helen; Myers, Philip C.; Bourke, Tyler L.] Harvard Smithsonian Ctr Astrophys, Radio & Geoastron Div, Cambridge, MA 02138 USA.
[Gutermuth, Robert A.; Wilson, Grant W.] Univ Massachusetts, Dept Astron, Amherst, MA 01003 USA.
[Hedden, Abigail] USA, Res Labs, Adelphi, MD 20783 USA.
RP Kirk, H (reprint author), McMaster Univ, Origins Inst, Hamilton, ON L8S 4L8, Canada.
EM kirkh@mcmaster.ca
FU Smithsonian Scholarly Studies Program grant; National Science Foundation
[0708158]
FX We thank the referee for suggestions which helped to clarify aspects of
this paper. We thank Steve Longmore for assistance with the Mopra
observing setup and data reduction. We thank Phil Edwards at ATNF for
allocating additional time to complete our Mopra observations, and all
the ATNF Narrabri staff for their support. We thank Rachel Friesen for
sending her ammonia temperature results prior to publication, and for
several interesting discussions on Serpens South. We thank Elaine
Winston and Scott Wolk for sharing the results of their Chandra survey
of Serpens South prior to publication. H.K. thanks Paola Caselli for a
valuable discussion on astrochemistry, Chris de Vries for answering
queries on his infall fitter on numerous occasions, and Fabian Heitsch
for a critical read-through of an earlier draft of this paper, as well
as sending a copy of his filamentary accretion paper pre-publication.
H.K. acknowledges funding from a Smithsonian Scholarly Studies Program
grant. This research was supported in part by the National Science
Foundation under grant number 0708158 (T.L.B.).
NR 62
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PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0004-637X
J9 ASTROPHYS J
JI Astrophys. J.
PD APR 1
PY 2013
VL 766
IS 2
AR 115
DI 10.1088/0004-637X/766/2/115
PG 14
WC Astronomy & Astrophysics
SC Astronomy & Astrophysics
GA 108UE
UT WOS:000316320900049
ER
PT J
AU Corona, BT
Wu, XW
Ward, CL
McDaniel, JS
Rathbone, CR
Walters, TJ
AF Corona, Benjamin T.
Wu, Xiaowu
Ward, Catherine L.
McDaniel, Jennifer S.
Rathbone, Christopher R.
Walters, Thomas J.
TI The promotion of a functional fibrosis in skeletal muscle with
volumetric muscle loss injury following the transplantation of
muscle-ECM
SO BIOMATERIALS
LA English
DT Article
DE Muscle; ECM (extracellular matrix); Transplantation; Fibrosis; Trauma;
VML (volumetric muscle loss)
ID CONTRACTION-INDUCED INJURY; RAT SOLEUS MUSCLE; MDX MICE;
GASTROCNEMIUS-MUSCLE; EXTRACELLULAR-MATRIX; BASEMENT-MEMBRANE; SATELLITE
CELLS; REGENERATION; REPAIR; RECOVERY
AB Tissue engineering strategies that primarily use biological extracellular matrices (ECMs) with or without the inclusion of a stem or progenitor cell source are under development for the treatment of trauma resulting in the loss of a large volume of skeletal muscle (i.e., volumetric muscle loss; VML). The explicit goal is to restore functional capacity to the injured tissue by promoting generation of muscle fibers. In the current study, a syngeneic muscle-derived ECM (mECM) was transplanted in a rat tibialis anterior (TA) muscle VML model. Instead of muscle fiber generation a large fibrotic mass was produced by mECM transplantation out to six months post-injury. Surprisingly, recovery of one-third of the original functional deficit was still achieved by two months post-injury following mECM transplantation. These counterintuitive findings may be due, at least in part, to the ability of mECM to attenuate muscle damage in the remaining muscle as compared to non-repaired muscle. These findings point to a novel role of biological ECMs for the treatment of VML, wherein the remaining muscle mass is protected from prolonged overload injury. Published by Elsevier Ltd.
C1 [Corona, Benjamin T.; Wu, Xiaowu; Ward, Catherine L.; McDaniel, Jennifer S.; Rathbone, Christopher R.; Walters, Thomas J.] USA, Inst Surg Res Extrem Trauma & Regenerat Med, Ft Sam Houston, TX 78234 USA.
RP Walters, TJ (reprint author), USA, Inst Surg Res Extrem Trauma & Regenerat Med, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM thomas.walters@us.army.mil
FU U.S. Army Medical Research and Medical Command [W81XWH-09-2-0177,
F_013-2010-USAISR]
FX We would like to thank Mrs. Janet Roe,Ms. Melissa Sanchez, and Dr. Kelly
Chen for their technical support of this work. Additionally, we thank
Dr. Ramon Coronado for his assistance in preparing the milled mECM and
Dr. Amit Aurora for his insightful discussion of the findings. This work
was funded by the U.S. Army Medical Research and Medical Command
(grants: W81XWH-09-2-0177 and F_013-2010-USAISR) awarded to TJW. All
components of this study including the decision where to publish were of
the sole discretion of the authors. The opinions or assertions contained
herein are the private views of the authors and are not to be construed
as official or reflecting the views of the Department of Defense (AR
360-5) or the United States Government. The authors are employees of the
U.S. government and this work was prepared as part of their official
duties.
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PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0142-9612
J9 BIOMATERIALS
JI Biomaterials
PD APR
PY 2013
VL 34
IS 13
BP 3324
EP 3335
DI 10.1016/j.biomaterials.2013.01.061
PG 12
WC Engineering, Biomedical; Materials Science, Biomaterials
SC Engineering; Materials Science
GA 114VE
UT WOS:000316770100017
PM 23384793
ER
PT J
AU Cheng, G
Muench, SP
Zhou, Y
Afanador, GA
Mui, EJ
Fomovska, A
Lai, BS
Prigge, ST
Woods, S
Roberts, CW
Hickman, MR
Lee, PJ
Leed, SE
Auschwitz, JM
Rice, DW
McLeod, R
AF Cheng, Gang
Muench, Stephen P.
Zhou, Ying
Afanador, Gustavo A.
Mui, Ernest J.
Fomovska, Alina
Lai, Bo Shiun
Prigge, Sean T.
Woods, Stuart
Roberts, Craig W.
Hickman, Mark R.
Lee, Patty J.
Leed, Susan E.
Auschwitz, Jennifer M.
Rice, David W.
McLeod, Rima
TI Design, synthesis, and biological activity of diaryl ether inhibitors of
Toxoplasma gondii enoyl reductase
SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
LA English
DT Article
DE TgENR; Triclosan; ADMET; Toxoplasma
ID CARRIER PROTEIN REDUCTASE; CONGENITAL TOXOPLASMOSIS;
PLASMODIUM-FALCIPARUM; TREATED INFANTS; UNITED-STATES; TRICLOSAN;
IDENTIFICATION; DERIVATIVES; ARYLATION; CHILDREN
AB Triclosan is a potent inhibitor of Toxoplasma gondii enoyl reductase (TgENR), which is an essential enzyme for parasite survival. In view of triclosan's poor druggability, which limits its therapeutic use, a new set of B-ring modified analogs were designed to optimize its physico-chemical properties. These derivatives were synthesized and evaluated by in vitro assay and TgENR enzyme assay. Some analogs display improved solubility, permeability and a comparable MIC50 value to that of triclosan. Modeling of these inhibitors revealed the same overall binding mode with the enzyme as triclosan, but the B-ring modifications have additional interactions with the strongly conserved Asn130. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Cheng, Gang] Univ Illinois, Dept Med Chem & Pharmacognosy, Drug Discovery Program, Chicago, IL 60612 USA.
[Muench, Stephen P.] Univ Leeds, Sch Biomed Sci, Leeds LS2 9JT, W Yorkshire, England.
[Zhou, Ying; Mui, Ernest J.; Fomovska, Alina; Lai, Bo Shiun; McLeod, Rima] Univ Chicago, Inst Genom & Syst Biol, Comm Genet, Dept Ophthalmol & Visual Sci, Chicago, IL 60637 USA.
[Zhou, Ying; Mui, Ernest J.; Fomovska, Alina; Lai, Bo Shiun; McLeod, Rima] Univ Chicago, Inst Genom & Syst Biol, Comm Immunol, Dept Ophthalmol & Visual Sci, Chicago, IL 60637 USA.
[Zhou, Ying; Mui, Ernest J.; Fomovska, Alina; Lai, Bo Shiun; McLeod, Rima] Univ Chicago, Inst Genom & Syst Biol, Comm Mol Med, Dept Ophthalmol & Visual Sci, Chicago, IL 60637 USA.
[Zhou, Ying; Mui, Ernest J.; Fomovska, Alina; Lai, Bo Shiun; McLeod, Rima] Univ Chicago, Chicago, IL 60637 USA.
[Afanador, Gustavo A.; Prigge, Sean T.] Johns Hopkins Sch Publ Hlth, Baltimore, MD 21205 USA.
[Woods, Stuart; Roberts, Craig W.] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow G4 0RE, Lanark, Scotland.
[Rice, David W.] Univ Sheffield, Dept Mol Biol & Biotechnol, Sheffield S10 2TN, S Yorkshire, England.
[Hickman, Mark R.; Lee, Patty J.; Leed, Susan E.; Auschwitz, Jennifer M.] Walter Reed Army Inst Res, Dept Discovery, Div Expt Therapeut, Silver Spring, MD 20910 USA.
RP McLeod, R (reprint author), Univ Chicago, Inst Genom & Syst Biol, Comm Genet, Dept Ophthalmol & Visual Sci, Chicago, IL 60637 USA.
EM rmcleod@midway.uchicago.edu
RI Roberts, Craig/B-8016-2008;
OI Roberts, Craig/0000-0002-0653-835X; Muench, Stephen/0000-0001-6869-4414
FU NIAID [U01 AI082180-0101]; Wellcome Trust; Mann and Cornwell family;
Rooney-Alden family; Taub family; Engel family; Mussilami family; MRC
[G1000567]
FX The authors are grateful for the financial support provided by NIAID
grant U01 AI082180-0101 and the Wellcome Trust and the support of the
Mann and Cornwell, Rooney-Alden, Taub, Engel and Mussilami families. SPM
is funded by an MRC Career Development Fellowship (G1000567). The
authors also thank Alan Kozikowski for his contributions. They also
thank K. Wroblewski for her assistance with statistical analyses of the
in vivo data. The opinions of the authors from Walter Reed Army
Institute of Research are their own and do not reflect the official
views of the Department of Defense.
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0960-894X
J9 BIOORG MED CHEM LETT
JI Bioorg. Med. Chem. Lett.
PD APR 1
PY 2013
VL 23
IS 7
BP 2035
EP 2043
DI 10.1016/j.bmcl.2013.02.019
PG 9
WC Chemistry, Medicinal; Chemistry, Organic
SC Pharmacology & Pharmacy; Chemistry
GA 113CD
UT WOS:000316642900024
PM 23453069
ER
PT J
AU Moore, BA
AF Moore, Bret A.
TI PTSD: past, present, and future
SO CNS SPECTRUMS
LA English
DT Editorial Material
DE posttraumatic stress; evidence based treatment; psychotherapy research;
psychopharmacology research; integrated treatment
ID POSTTRAUMATIC-STRESS-DISORDER
C1 [Moore, Bret A.] USA, Southern Reg Med Command, Warrior Resiliency Program, San Antonio, TX USA.
RP Moore, BA (reprint author), Warrior Resiliency Program, 7800 1H 10 West,Suite 300, San Antonio, TX 78230 USA.
EM bret.moore@us.army.mil
NR 10
TC 0
Z9 0
U1 0
U2 14
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1092-8529
J9 CNS SPECTRUMS
JI CNS Spectr.
PD APR
PY 2013
VL 18
IS 2
BP 71
EP 72
DI 10.1017/S1092852913000187
PG 2
WC Clinical Neurology; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 119WO
UT WOS:000317130200003
PM 23557626
ER
PT J
AU Brunye, TT
Gagnon, SA
Paczynski, M
Shenhav, A
Mahoney, CR
Taylor, HA
AF Brunye, Tad T.
Gagnon, Stephanie A.
Paczynski, Martin
Shenhav, Amitai
Mahoney, Caroline R.
Taylor, Holly A.
TI Happiness by association: Breadth of free association influences
affective states
SO COGNITION
LA English
DT Article
DE Affect; Association; Creativity; Positive psychology; Depression
ID POSITIVE AFFECT; MOOD; ATTENTION; MEMORY; NEUROGENESIS; INFORMATION;
EXPERIENCE; RUMINATION; THOUGHT; BRAIN
AB Several studies have demonstrated that affective states influence the number of associations formed between remotely related concepts. Someone in a neutral or negative affective state might draw the association between cold and hot, whereas someone in a positive affective state might spontaneously form the more distant association between cold and sneeze. Could the reverse be true, that generating increasingly broad or narrow associations will put someone in a more or less positive affective state? We test this possibility by using verbal free association tasks, and asking whether the breadth of semantic associativity between cue words and generated responses might predict resulting affective states. Two experiments show that generating broader associations, regardless of their valence, changes affect; specifically, broader associations lowered negative affect and marginally increased positive affect over time. These findings carry implications for theories positing interactions between brain areas mediating associative processing and affect, and may hold promise for enhancing affect in clinical contexts. Published by Elsevier B.V.
C1 [Brunye, Tad T.; Gagnon, Stephanie A.; Paczynski, Martin; Mahoney, Caroline R.; Taylor, Holly A.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA.
[Brunye, Tad T.; Gagnon, Stephanie A.; Mahoney, Caroline R.] USA, NSRDEC, Natick, MA 01760 USA.
[Shenhav, Amitai] Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA.
[Gagnon, Stephanie A.] Stanford Univ, Dept Psychol, Stanford, CA 94305 USA.
RP Brunye, TT (reprint author), Tufts Univ, Dept Psychol, 490 Boston Ave, Medford, MA 02155 USA.
EM tbrunye@alumni.tufts.edu
NR 35
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Z9 6
U1 3
U2 29
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0010-0277
J9 COGNITION
JI Cognition
PD APR
PY 2013
VL 127
IS 1
BP 93
EP 98
DI 10.1016/j.cognition.2012.11.015
PG 6
WC Psychology, Experimental
SC Psychology
GA 112JS
UT WOS:000316589100009
PM 23376294
ER
PT J
AU Allen, JB
Cornwell, CF
Devine, BD
Welch, CR
AF Allen, J. B.
Cornwell, C. F.
Devine, B. D.
Welch, C. R.
TI Simulations of anisotropic grain growth in single phase materials using
Q-state Monte Carlo
SO COMPUTATIONAL MATERIALS SCIENCE
LA English
DT Article
DE Grain growth; Anisotropy; Q-state Monte Carlo; Computer simulation
ID COMPUTER-SIMULATION; NANOCRYSTALLINE MATERIALS; MICROSTRUCTURE;
EVOLUTION; COATINGS; KINETICS; FILMS
AB The Q-state Monte Carlo, Potts model is used to investigate 2D, anisotropic, grain growth in single-phase materials using hexagonal grain elements. While many factors can affect the microstructure anisotropy, this research focusses on the role played by grain boundary energy anisotropy. Specifically, for each computed grain orientation and surface normal, the corresponding surface energy is assigned through a mapping process using Wulff plots. Various Wulff plot geometries are considered, and their respective impact on the grain growth anisotropy is evaluated. In addition to demonstrating the utility of this method for use with anisotropic grain growth models, this work advances the state of the art by providing a means of quantifying the degree of anisotropy through the use of statistics generated by frequency distributions of normalized grain radii. Published by Elsevier B.V.
C1 [Allen, J. B.; Cornwell, C. F.; Devine, B. D.; Welch, C. R.] USA, Informat Technol Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Allen, JB (reprint author), 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM Jeffrey.B.Allen@erdc.dren.mil
FU U.S. Army Engineer Research and Development Center Directed Research
Program: "Nanoscale Studies of Polycrystalline Materials with Emphasis
on Ceramics Synthesis" as part of the Advanced Material Initiative
program; U.S. Army Engineer Research and Development Center Directed
Research Program: "Effects of Grain Boundaries on Ceramic Properties" as
part of the Advanced Material Initiative program
FX This study was funded through the U.S. Army Engineer Research and
Development Center Directed Research Programs: "Nanoscale Studies of
Polycrystalline Materials with Emphasis on Ceramics Synthesis" and
"Effects of Grain Boundaries on Ceramic Properties" as part of the
Advanced Material Initiative program.
NR 25
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U1 0
U2 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0927-0256
J9 COMP MATER SCI
JI Comput. Mater. Sci.
PD APR
PY 2013
VL 71
BP 25
EP 32
DI 10.1016/j.commatsci.2013.01.022
PG 8
WC Materials Science, Multidisciplinary
SC Materials Science
GA 113IY
UT WOS:000316661300004
ER
PT J
AU Stanley, JK
Kennedy, AJ
Bednar, AJ
Chappell, MA
Seiter, JM
Averett, DE
Steevens, JA
AF Stanley, Jacob K.
Kennedy, Alan J.
Bednar, Anthony J.
Chappell, Mark A.
Seiter, Jennifer M.
Averett, Daniel E.
Steevens, Jeffery A.
TI Impact assessment of dredging to remove coal fly ash at the Tennessee
Valley Authority Kingston Fossil plant using fathead minnow elutriate
exposures
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Fly ash; Elutriate; Pimephales promelas; Bioaccumulation; Metal
ID PIMEPHALES-PROMELAS; CHRONIC TOXICITY; METAL SEQUESTRATION; AQUATIC
ORGANISMS; TISSUE RESIDUES; RAINBOW-TROUT; SELENIUM; CHROMIUM;
BIOACCUMULATION; GROWTH
AB On December 22, 2008, failure of an earthen containment structure resulted in the release of approximately 4.1 million m3 of coal fly ash into the Emory River and the surrounding area from the Tennessee Valley Authority Kingston Fossil Plant near Kingston, Tennessee, USA. The purpose of the present study was to assess the potential of dredging activities performed to remove the fly ash from the river to result in increased risk to pelagic fish, with special consideration of mobilization of metals. Elutriates were created using two sources of fly ash by bubbling with air over 10 d. This elutriate preparation method was designed to represent worst-case conditions for oxidation, metal release, and dissolution. Larval and juvenile Pimephales promelas underwent 10-d exposures to these elutriates. Larval end points included survival and biomass, and juvenile end points included survival, length, biomass, liver somatic index, and bioaccumulation. No significant toxicity was observed. Bioaccumulation of metals in juveniles was found to be primarily attributable to metals associated with particles in the gut. Results suggest little potential for toxicity to related fish species due to fly ash removal dredging activities given the extreme conditions represented by the elutriates in the present study. Environ. Toxicol. Chem. 2013;32:822830. (c) 2013 SETAC
C1 [Stanley, Jacob K.; Kennedy, Alan J.; Bednar, Anthony J.; Chappell, Mark A.; Seiter, Jennifer M.; Averett, Daniel E.; Steevens, Jeffery A.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.
RP Stanley, JK (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.
EM jacob.k.stanley@us.army.mil
NR 37
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U1 4
U2 21
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-7268
EI 1552-8618
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD APR
PY 2013
VL 32
IS 4
BP 822
EP 830
DI 10.1002/etc.2137
PG 9
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 112VG
UT WOS:000316621700013
PM 23354755
ER
PT J
AU Pushpakaran, BN
Hinojosa, M
Bayne, SB
Veliadis, V
Urciuoli, D
El-Hinnawy, N
Borodulin, P
Gupta, S
Scozzie, C
AF Pushpakaran, Bejoy N.
Hinojosa, Miguel
Bayne, Stephen B.
Veliadis, Victor
Urciuoli, Damian
El-Hinnawy, Nabil
Borodulin, Pavel
Gupta, Shalini
Scozzie, Charles
TI High Temperature Unclamped Inductive Switching Mode Evaluation of SiC
JFET
SO IEEE ELECTRON DEVICE LETTERS
LA English
DT Article
DE 1200 V; high temperature; junction field-effect transistor (JFET);
pulsed testing; silicon carbide (SiC); triode breakdown; unclamped
inductive switching (UIS)
ID PERFORMANCE
AB Silicon carbide (SiC) unipolar transistors are an efficient choice in the design of high temperature 1200 V switching power supplies and dc-dc converters. To reduce the form factor and increase the power density of the circuit, the switching frequency must be high. This intensifies the negative impact of parasitic inductance and results in high voltage spikes that can drive a switching device into breakdown, followed by rapid destruction. To study the device performance under unclamped inductive switching (UIS) conditions, a normally-ON 1200 V/13-A SiC junction field-effect transistor (JFET) is driven into punch through breakdown using a single pulse. The testing is performed using an UIS setup, in which energy initially stored in an inductor is discharged through the JFET. The testing comprises of 90 single pulses each at 25 degrees C and 100 degrees C case temperatures for different gate voltages and drain current values. The peak energy and power dissipated in the JFET are 621 mJ and 16 kW, respectively, at the rated 1200 V blocking voltage and 13-A drain current. The JFET triode breakdown characteristics are unchanged after 180 single-pulse switching events indicating the robust nature of the device under extreme breakdown conditions. In addition, the 621 mJ peak UIS energy and its corresponding 8871 mJ/cm(2) density dissipated in the JFET are the highest reported for any SiC power device.
C1 [Pushpakaran, Bejoy N.; Hinojosa, Miguel; Bayne, Stephen B.] Texas Tech Univ, Dept Elect & Comp Engn, Lubbock, TX 79409 USA.
[Veliadis, Victor; El-Hinnawy, Nabil; Borodulin, Pavel; Gupta, Shalini] Northrop Grumman Elect Syst, Linthicum, MD 21090 USA.
[Urciuoli, Damian; Scozzie, Charles] USA, Res Lab, Adelphi, MD 20783 USA.
RP Pushpakaran, BN (reprint author), Texas Tech Univ, Dept Elect & Comp Engn, Lubbock, TX 79409 USA.
EM bejoy.pushpakaran@ttu.edu; miguel.hinojosa@ttu.edu;
stephen.bayne@ttu.edu; vic-tor.veliadis@ngc.com;
damian.urciuoli@us.army.mil; nabil.elhinnawy@ngc.com;
pavel.borodulin@ngc.com; shalini.gupta@ngc.com;
charles.scozzie@us.army.mil
OI Pushpakaran, Bejoy/0000-0002-1342-5951
FU U.S. Army Research Laboratory
FX This work was supported by the U.S. Army Research Laboratory. The review
of this letter was arranged by Editor S.-H. Ryu.
NR 11
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U1 0
U2 12
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0741-3106
EI 1558-0563
J9 IEEE ELECTR DEVICE L
JI IEEE Electron Device Lett.
PD APR
PY 2013
VL 34
IS 4
BP 526
EP 528
DI 10.1109/LED.2013.2247020
PG 3
WC Engineering, Electrical & Electronic
SC Engineering
GA 115LG
UT WOS:000316813100017
ER
PT J
AU Wei, W
He, T
Bisdikian, C
Goeckel, D
Jiang, B
Kaplan, L
Towsley, D
AF Wei, Wei
He, Ting
Bisdikian, Chatschik
Goeckel, Dennis
Jiang, Bo
Kaplan, Lance
Towsley, Don
TI Impact of In-Network Aggregation on Target Tracking Quality Under
Network Delays
SO IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS
LA English
DT Article
DE In-network aggregation; Target tracking; Brownian motion; Mean squared
error
ID WIRELESS SENSOR NETWORKS; CLASSIFICATION
AB In this paper, we investigate how in-network aggregation approach impacts the target tracking quality in multi-hop wireless sensor networks under network delays. Specifically, we use the mean squared error (MSE) of the target location estimate to quantify the target tracking quality, and investigate how in-network aggregation affects the MSE. To obtain insights without being obscured by onerous mathematical details, we assume a Brownian motion mobility model for the target, Gaussian measurement noise for the sensors, and independent per-hop delays. Under the above assumptions, we first propose an aggregation scheme that preserves a sufficient statistic for optimal tracking under data aggregation at the intermediate nodes and arbitrary network delays. We then analytically study the impact of aggregation in three increasingly more complicated scenarios: single task tracking with only transmission delay, single task tracking with both transmission delay and queueing delay at intermediate nodes, and multi-task tracking. Our results demonstrate that in-network aggregation improves tracking quality in all three scenarios. Furthermore, our analysis provides guidelines on how to choose aggregation parameters in practice.
C1 [Wei, Wei; Jiang, Bo; Towsley, Don] Univ Massachusetts, Dept Comp Sci, Amherst, MA 01003 USA.
[He, Ting; Bisdikian, Chatschik] IBM TJ Watson Res Ctr, Hawthorne, NY 10532 USA.
[Goeckel, Dennis] Univ Massachusetts, Dept Elect & Comp Engn, Amherst, MA 01003 USA.
[Kaplan, Lance] USA, Res Lab, Adelphi, MD 20783 USA.
RP Wei, W (reprint author), Univ Massachusetts, Dept Comp Sci, Amherst, MA 01003 USA.
EM wei-wei@cs.umass.edu
FU National Science Foundation [EEC-0313747]; U.S. Army Research
Laboratory; U.K. Ministry of Defence [W911NF-06-3-0001]
FX This work was sponsored in part by the National Science Foundation under
grants EEC-0313747, and by the U.S. Army Research Laboratory and the
U.K. Ministry of Defence and was accomplished under Agreement Number
W911NF-06-3-0001. The views and conclusions contained in this document
are those of the author(s) and should not be interpreted as representing
the official policies, either expressed or implied, of the U. S. Army
Research Laboratory, the U. S. Government, the U. K. Ministry of Defence
or the U. K. Government. The U. S. and U. K. Governments are authorized
to reproduce and distribute reprints for Government purposes
notwithstanding any copyright notation hereon.
NR 28
TC 1
Z9 2
U1 1
U2 7
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0733-8716
J9 IEEE J SEL AREA COMM
JI IEEE J. Sel. Areas Commun.
PD APR
PY 2013
VL 31
IS 4
BP 808
EP 818
DI 10.1109/JSAC.2013.130416
PG 11
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA 115HB
UT WOS:000316802100016
ER
PT J
AU Wilk, JE
Bliese, PD
Thomas, JL
Wood, MD
McGurk, D
Castro, CA
Hoge, CW
AF Wilk, Joshua E.
Bliese, Paul D.
Thomas, Jeffrey L.
Wood, Michael D.
McGurk, Dennis
Castro, Carl A.
Hoge, Charles W.
TI Unethical Battlefield Conduct Reported by Soldiers Serving in the Iraq
War
SO JOURNAL OF NERVOUS AND MENTAL DISEASE
LA English
DT Article
DE Combat; ethics; posttraumatic stress disorder
ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; COMBAT EXPOSURE;
POPULATION; VIETNAM; VIOLENCE; PREVALENCE; DEPLOYMENT; SYMPTOMS;
MILITARY
AB Research involving military service members has shown a strong relationship between combat experiences and increased risk for posttraumatic stress disorder (PTSD) and other mental health problems. Comparatively little research has examined the relationship between combat experiences, PTSD, aggression, and unethical conduct on the battlefield, although news stories sometimes suggest links between unethical conduct and disorders such as PTSD. This study systematically examined whether unethical conduct is a proxy for aggression and whether specific combat experiences and PTSD are independently associated with unethical behavior. The results of this study indicate that aggression (beta = 0.30) and specific combat experiences (particularly, witnessing war atrocities [beta = 0.14] and fighting [beta = 0.13]) are much more strongly associated with unethical conduct than is PTSD (beta = 0.04).
C1 [Wilk, Joshua E.; Bliese, Paul D.; Thomas, Jeffrey L.; McGurk, Dennis; Hoge, Charles W.] USA, Med Res & Mat Command, Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD USA.
[Wood, Michael D.] USA, Med Res & Mat Command, Med Res Unit Europe, Walter Reed Army Inst Res, Heidelberg, Germany.
[Castro, Carl A.] USA, Med Res & Mat Command, Mil Operat Med Res Program, Frederick, MD USA.
RP Wilk, JE (reprint author), Walter Reed Army Inst Res, Dept Mil Psychiat, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM joshua.wilk@amedd.army.mil
NR 33
TC 3
Z9 3
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0022-3018
J9 J NERV MENT DIS
JI J. Nerv. Ment. Dis.
PD APR
PY 2013
VL 201
IS 4
BP 259
EP 265
DI 10.1097/NMD.0b013e318288d302
PG 7
WC Clinical Neurology; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 117HV
UT WOS:000316945100001
PM 23538969
ER
PT J
AU Zachar, MR
Labella, C
Kittle, CP
Baer, PB
Hale, RG
Chan, RK
AF Zachar, Michael R.
Labella, Carl
Kittle, Christopher P.
Baer, Pamela Brown
Hale, Robert G.
Chan, Rodney K.
TI Characterization of Mandibular Fractures Incurred From Battle Injuries
in Iraq and Afghanistan From 2001-2010
SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
LA English
DT Article
ID MAXILLOFACIAL FRACTURES; FACIAL FRACTURES; ENDURING FREEDOM; NECK
INJURIES; BLAST; PATTERNS; MANAGEMENT; TRENDS; HEAD
AB Purpose: The mandible is the most commonly fractured bone in the craniomaxillofacial skeleton among military casualties. The purpose of this study was to characterize the nature and severity of mandibular fractures incurred by US military personnel during combat.
Materials and Methods: We queried the Joint Theater Trauma Registry from October 2001 to April 2011 using all pertinent International Classification of Diseases, Ninth Revision codes to identify fractures of the mandible. Fractures were then classified based on type and location. Chart reviews were performed on the subset of patients who were treated at San Antonio Military Medical Center to further classify the anatomic pattern and treatment of these fractures.
Results: We identified 391 patients with mandibular fractures, of whom 45 were transferred to San Antonio Military Medical Center. Open fractures were seen in 75% of patients. Two or more fractures of the mandible were seen in 51% of patients. Comminuted fractures were present in 84%, and 31% had segmental losses. Eighty-six percent of fractures were operative; two-thirds of patients required a single surgical procedure, whereas the remaining one-third required multiple procedures. Forty-six percent of patients had pan-facial fractures.
Conclusions: Mandibular fractures as a result of combat blast injuries were characterized by a high incidence of open, comminuted, multiple fractures. Associated facial fractures were common. (C) 2013 American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 71:734-742, 2013
C1 [Zachar, Michael R.; Labella, Carl; Kittle, Christopher P.] San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA.
[Baer, Pamela Brown; Hale, Robert G.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Chan, Rodney K.] USA, Inst Surg Res, Clin Div, Ft Sam Houston, TX 78234 USA.
RP Chan, RK (reprint author), San Antonio Mil Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM rodney.k.chan@amedd.army.mil
OI Brown Baer, Pamela/0000-0001-6964-1955
NR 26
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U1 0
U2 3
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0278-2391
J9 J ORAL MAXIL SURG
JI J. Oral Maxillofac. Surg.
PD APR
PY 2013
VL 71
IS 4
BP 734
EP 742
DI 10.1016/j.joms.2012.10.030
PG 9
WC Dentistry, Oral Surgery & Medicine
SC Dentistry, Oral Surgery & Medicine
GA 114MP
UT WOS:000316745800024
PM 23351482
ER
PT J
AU Geringer, JR
Tuan, CY
Lindsey, PD
AF Geringer, J. R.
Tuan, C. Y.
Lindsey, P. D.
TI Assessment of Software for Blast Loading and Structural Response
Analysis Using a Lightweight Steel-Joist Roof as a Test Case
SO JOURNAL OF PERFORMANCE OF CONSTRUCTED FACILITIES
LA English
DT Article; Proceedings Paper
CT 6th ASCE Forensic Engineering Congress
CY OCT 31-NOV 03, 2012
CL San Francisco, CA
SP ASCE
DE Blast loads; Steel structures; Joist; Finite-element models; DYNA3D;
STAAD; SBEDS; ConWep; BlastX
AB The purpose of this paper is to evaluate the current multihazard loading environments when future blast loadings are included. While most of the currently available software programs for the physical testing of normal design loading conditions have been validated, the testing does not include the blast environment. It has not been determined whether these programs can be used when blast loads are included. Currently, designers use multiple software packages to perform multihazard analyses when blast loads are involved, making it difficult to compare the results. This analysis has as major topics air-blast and structural responses. The three standard air-blast codes used are ConWep, BlastX, and SBEDS, and the four structural response codes used are SBEDS, STAAD, ADINA, and DYNA3D. All analyses are compared against a test series that loaded standard open web steel joist sections dynamically with an air-blast load. This paper compares the output and results of each program against the test results to determine if the software is comparable in an effort to simplify the multihazard analysis process. DOI: 10.1061/(ASCE)CF.1943-5509.0000299. (C) 2013 American Society of Civil Engineers.
C1 [Geringer, J. R.; Lindsey, P. D.] USA, Corps Engineers, Protect Design Ctr, Omaha, NE 68102 USA.
[Tuan, C. Y.] Univ Nebraska Lincoln, Dept Civil Engn, Omaha, NE 68182 USA.
EM john.r.geringer@usace.army.mil
NR 16
TC 0
Z9 0
U1 0
U2 13
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0887-3828
EI 1943-5509
J9 J PERFORM CONSTR FAC
JI J. Perform. Constr. Facil.
PD APR
PY 2013
VL 27
IS 2
BP 144
EP 154
DI 10.1061/(ASCE)CF.1943-5509.0000299
PG 11
WC Construction & Building Technology; Engineering, Civil
SC Construction & Building Technology; Engineering
GA 118ZK
UT WOS:000317065900003
ER
PT J
AU Rens, KL
Liu, R
Foltz, SD
AF Rens, Kevin L.
Liu, Rui
Foltz, Stuart D.
TI Sustainable Approach for Optimal Steel Sheet Pile Structure Assessment,
Maintenance, and Rehabilitation
SO JOURNAL OF PERFORMANCE OF CONSTRUCTED FACILITIES
LA English
DT Article; Proceedings Paper
CT 6th ASCE Forensic Engineering Congress
CY OCT 31-NOV 03, 2012
CL San Francisco, CA
SP ASCE
DE Steel sheet pile; Assessment; Maintenance; Rehabilitation;
Sustainability; Life-cycle cost analysis
AB An improved steel sheet pile (SSP) inspection procedure is proposed in this paper, which couples the field inspection condition-index methodology previously developed by the U. S. Army Corps of Engineers with reliability assessments to quantify the life-cycle costs and environmental impacts associated with various maintenance and repair (M&R) scenarios. Maintenance and repair strategies over the analysis period (from present to the end of the structure's lifetime) are determined through reliability assessment for structures with relatively low condition indices. The level of maintenance activity is then to be determined by the life-cycle cost analysis and environmental life-cycle assessment of M&R alternatives. The optimal M&R alternative is the one with the lowest cost combined with minimal environmental impact. Using these methodologies, the SSP structure owners will gain improved capabilities to monitor present-day conditions of SSP infrastructure and prioritize structures that will require sustainable M&R. Further research is proposed to collect real field-inspection data and create M&R records that can be used to estimate the reliability more accurately. In addition, the methodology developed for this relatively simple type of structure can be extended to more complex and critical structural systems such as gates, valves, and other components making up locks, dams, and other related navigational facilities. DOI: 10.1061/(ASCE)CF.1943-5509.0000301. (C) 2013 American Society of Civil Engineers.
C1 [Rens, Kevin L.; Liu, Rui] Univ Colorado, Dept Civil Engn, Denver, CO 80217 USA.
[Foltz, Stuart D.] USA, Construct Engn Res Lab, Champaign, IL 61826 USA.
EM Kevin.rens@ucdenver.edu; rui.liu@ucdenver.edu;
Stuart.D.Foltz@usace.army.mil
FU U.S. Army Construction Engineering Research Laboratory
[W9132T-10-P-0082]
FX This study was funded by the U.S. Army Construction Engineering Research
Laboratory under Project No. W9132T-10-P-0082.
NR 27
TC 0
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U1 3
U2 16
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0887-3828
EI 1943-5509
J9 J PERFORM CONSTR FAC
JI J. Perform. Constr. Facil.
PD APR
PY 2013
VL 27
IS 2
BP 181
EP 190
DI 10.1061/(ASCE)CF.1943-5509.0000301
PG 10
WC Construction & Building Technology; Engineering, Civil
SC Construction & Building Technology; Engineering
GA 118ZK
UT WOS:000317065900007
ER
PT J
AU Delaney, HM
Wang, E
Melish, M
AF Delaney, H. M.
Wang, E.
Melish, M.
TI Comprehensive strategy including prophylactic mupirocin to reduce
Staphylococcus aureus colonization and infection in high-risk neonates
SO JOURNAL OF PERINATOLOGY
LA English
DT Article
DE Staphylococcus aureus; methicillin-resistant Staphylococcus aureus;
neonatal intensive care unit; mupirocin; surveillance
ID INTENSIVE-CARE UNITS; NASAL MUPIROCIN; NOSOCOMIAL-INFECTIONS; INTRANASAL
MUPIROCIN; SURVEILLANCE; RESISTANCE; OUTBREAK; OINTMENT; INFANTS; TRENDS
AB OBJECTIVE: To examine the use of long-term prophylactic mupirocin as part of a comprehensive strategy in reducing Staphylococcus aureus colonization and infection in a neonatal intensive care unit (NICU).
STUDY DESIGN: Twice daily mupirocin was applied to all infants admitted to the NICU throughout hospitalization starting in 2004. S. aureus surveillance was implemented in 2008. The efficacy of these practices was evaluated with a retrospective review of infants admitted from 2004 to 2010 found to be colonized or infected with S. aureus.
RESULT: During the study period, 66 of 6283 NICU infants had a S. aureus infection With 67% methicillin resistance. There were three distinctive S. aureus outbreaks, the first being a methicillin-resistant strain July 2004. After implementation of daily mupirocin, the outbreak was eradicated and the rate of S. aureus infection significantly decreased (1.82 to 0.40/1000 patient-days-at-risk, P=0.0049). Mupirocin was discontinued March 2005 followed by a methicillin-sensitive S. aureus outbreak November 2005. In December 2005, mupirocin was reinstituted and has continued to present day, again significantly reducing S. aureus infections (1.42 to 0.33/1000 patient-days-at-risk, P<0.0001) with zero isolates resistant to mupirocin. In the pre-mupirocin period, S. aureus colonization was upwards of 60% now with rates typically <5%. S. aureus colonization strongly predicted later invasive infection (P<0.0001).
CONCLUSION: Although controversial, prophylactic mupirocin in all NICU infants has acted as a barrier to colonization and markedly decreased S. aureus infection rates over a 5-year period. Journal of Perinatology (2013) 33, 313-318; doi:10.1038/jp.2012.102; published online 23 August 2012
C1 [Delaney, H. M.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA.
[Wang, E.] Univ Hawaii, Undergrad Sch, Honolulu, HI 96822 USA.
[Melish, M.] Kapiolani Med Ctr Women & Children, Dept Pediat, Honolulu, HI USA.
RP Delaney, HM (reprint author), Tripler Army Med Ctr, Dept Pediat, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM heather.delaney@amedd.army.mil
NR 30
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U1 0
U2 7
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0743-8346
J9 J PERINATOL
JI J. Perinatol.
PD APR
PY 2013
VL 33
IS 4
BP 313
EP 318
DI 10.1038/jp.2012.102
PG 6
WC Obstetrics & Gynecology; Pediatrics
SC Obstetrics & Gynecology; Pediatrics
GA 115SX
UT WOS:000316833300013
PM 22918547
ER
PT J
AU Rupp, TL
Wesensten, NJ
Newman, R
Balkin, TJ
AF Rupp, Tracy L.
Wesensten, Nancy J.
Newman, Rachel
Balkin, Thomas J.
TI PER3 and ADORA2A polymorphisms impact neurobehavioral performance during
sleep restriction
SO JOURNAL OF SLEEP RESEARCH
LA English
DT Article
DE cognitive performance; genetic polymorphisms; individual differences;
recovery sleep; sleep restriction
ID GENETIC-VARIATION; PHASE SYNDROME; DEPRIVATION
AB The objective of the study was to determine whether ADORA2A or PER3 polymorphisms contribute to individual responsivity to sleep restriction. Nineteen healthy adults (ages 1839, 11 males, 8 females) underwent sleep restriction (SR) which consisted of seven nights of 3h time in bed (TIB) (04:0007:00). SR was preceded by seven in-laboratory nights of 10h TIB (21:0007:00) and followed by three nights of 8h TIB (23:0007:00). Volunteers underwent psychomotor vigilance, objective alertness, and subjective sleepiness assessments throughout. Volunteers were genotyped for the PER3 VNTR polymorphism (PER34/4 n=7; PER34/5 n=10; PER35/5 n=2) and the ADORA2A c.1083T>C polymorphism, (ADORA2AC/T n=9; ADORA2AT/T n=9; ADORA2AC/C n=1) using polymerase chain reaction (PCR). Separate mixed-model anovas were used to assess contributions of ADORA2A and PER3 polymorphisms. Results showed that PER34/4 and ADORA2AC/T individuals expressed greater behavioral resiliency to SR compared to PER4/5and ADORA2AT/T individuals. Our findings contrast with previously reported non-significant effects for the PER3 polymorphism under a less challenging sleep restriction regimen (4h TIB per night for five nights). We conclude that PER3 and ADORA2A polymorphisms become more behaviorally salient with increasing severity and/or duration of sleep restriction (based on psychomotor vigilance). Given the small sample size these results are preliminary and require replication.
C1 [Rupp, Tracy L.; Wesensten, Nancy J.; Newman, Rachel; Balkin, Thomas J.] Walter Reed Army Inst Res, Behav Biol Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA.
RP Wesensten, NJ (reprint author), Walter Reed Army Inst Res, Behav Biol Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM nancy.wesensten@US.army.mil
FU US Army Medical Research and Materiel Command
FX This material has been reviewed by the Walter Reed Army Institute of
Research, and there is no objection to its presentation and/or
publication. The opinions or assertions contained herein are the private
views of the authors and are not to be construed as official or as
reflecting the position of the Department of the Army of the Department
of Defense. This work was supported by the US Army Medical Research and
Materiel Command. We thank the student contractors, military personnel,
on-call physicians Drs. John Hughes and Melanie Guerrero, and study
participants.
NR 14
TC 13
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U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1105
J9 J SLEEP RES
JI J. Sleep Res.
PD APR
PY 2013
VL 22
IS 2
BP 160
EP 165
DI 10.1111/j.1365-2869.2012.01062.x
PG 6
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 117OX
UT WOS:000316964100007
PM 23171222
ER
PT J
AU Klemcke, HG
DeKroon, RM
Mocanu, M
Robinette, JB
Alzate, O
AF Klemcke, Harold G.
DeKroon, Robert M.
Mocanu, Mihaela
Robinette, Jennifer B.
Alzate, Oscar
TI Cardiac mitochondrial proteomic expression in inbred rat strains
divergent in survival time after hemorrhage
SO PHYSIOLOGICAL GENOMICS
LA English
DT Article
DE inbred rats; hemorrhage; proteomics; respiration; cellular pathways;
mitochondrial proteomics; 2D DIGE; quantitative intact proteomics
ID ACYL-COA DEHYDROGENASE; COMBAT CASUALTY CARE; HYDROGEN-SULFIDE; ALDEHYDE
DEHYDROGENASE; MYOCARDIAL-ISCHEMIA; GEL-ELECTROPHORESIS;
ELECTRON-TRANSPORT; BASE-LINE; CARNITINE PALMITOYLTRANSFERASE-2;
ISCHEMIA/REPERFUSION INJURY
AB We have previously identified inbred rat strains differing in survival time to a severe controlled hemorrhage (StaH). In efforts to identify cellular mechanisms and ultimately genes that are important contributors to enhanced STaH, we conducted a study to characterize potential differences in cardiac mitochondrial proteins in these rats. Inbred rats from three strains [Brown Norway/Medical College of Wisconsin (BN); Dark Agouti (DA), and Fawn Hooded Hypertensive (FHH)] with different StaH (DA = FHH > BN) were assigned to one of three treatment groups (n = 4/strain): nonoperated controls, surgically catheterized rats, or rats surgically catheterized and hemorrhaged 24 h postsurgery. Rats were euthanized 30 min after handling or 30 min after initiation of a 26 min hemorrhage. After euthanasia, hearts were removed and mitochondria isolated. Differential protein expression was determined using 2D DIGE-based Quantitative Intact Proteomics and proteins identified by MALDI/TOF mass spectrometry. Hundreds of proteins (791) differed among inbred rat strains (P <= 0.038), and of these 81 were identified. Thirty-eight were unique proteins and 43 were apparent isoforms. For DA rats (longest STaH), 36 proteins increased and 30 decreased compared with BN (shortest STaH). These 81 proteins were associated with lipid (e.g., acyl CoA dehydrogenase) and carbohydrate (e.g., fumarase) metabolism, oxidative phosphorylation (e.g., ubiquinol-cytochrome C reductase), ATP synthesis (F-1 ATPase), and H2S synthesis (3-mercaptopyruvate sulfurtransferase). Although we cannot make associations between these identified mitochondrial proteins and StaH, our data do provide evidence for future candidate proteins with which to consider such associations.
C1 [Klemcke, Harold G.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[DeKroon, Robert M.; Mocanu, Mihaela; Robinette, Jennifer B.; Alzate, Oscar] Univ N Carolina, Syst Prote Core Lab, Chapel Hill, NC USA.
[Mocanu, Mihaela; Robinette, Jennifer B.; Alzate, Oscar] Univ N Carolina, Program Mol Biol & Biotechnol, Chapel Hill, NC 27599 USA.
[DeKroon, Robert M.; Alzate, Oscar] Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC USA.
RP Klemcke, HG (reprint author), USA, Inst Surg Res, 3650 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM harold.klemcke@amedd.army.mil
NR 140
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U1 11
U2 22
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1094-8341
J9 PHYSIOL GENOMICS
JI Physiol. Genomics
PD APR
PY 2013
VL 45
IS 7
BP 243
EP 255
DI 10.1152/physiolgenomics.00118.2012
PG 13
WC Cell Biology; Genetics & Heredity; Physiology
SC Cell Biology; Genetics & Heredity; Physiology
GA 118CJ
UT WOS:000316999800001
PM 23386204
ER
PT J
AU Greitens, SC
Koehler-Derrick, G
AF Greitens, Sheena Chestnut
Koehler-Derrick, Gabriel
TI Technology, Data, and Politics Introduction
SO PS-POLITICAL SCIENCE & POLITICS
LA English
DT Editorial Material
C1 [Greitens, Sheena Chestnut] Harvard Univ, Cambridge, MA 02138 USA.
[Koehler-Derrick, Gabriel] US Mil Acad, West Point, NY USA.
RP Greitens, SC (reprint author), Harvard Univ, Cambridge, MA 02138 USA.
NR 13
TC 0
Z9 0
U1 0
U2 1
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1049-0965
J9 PS-POLIT SCI POLIT
JI PS-Polit. Sci. Polit.
PD APR
PY 2013
VL 46
IS 2
BP 259
EP 261
DI 10.1017/S1049096513000255
PG 3
WC Political Science
SC Government & Law
GA 117ZN
UT WOS:000316992200010
ER
PT J
AU Koehler-Derrick, G
AF Koehler-Derrick, Gabriel
TI Quantifying Anecdotes: Google Search Data and Political Developments in
Egypt
SO PS-POLITICAL SCIENCE & POLITICS
LA English
DT Article
C1 US Mil Acad, West Point, NY 10996 USA.
RP Koehler-Derrick, G (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 35
TC 1
Z9 1
U1 0
U2 3
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1049-0965
J9 PS-POLIT SCI POLIT
JI PS-Polit. Sci. Polit.
PD APR
PY 2013
VL 46
IS 2
BP 291
EP 298
DI 10.1017/S1049096513000267
PG 8
WC Political Science
SC Government & Law
GA 117ZN
UT WOS:000316992200014
ER
PT J
AU Omelchenko, IV
Shishkin, OV
Gorb, L
Hill, FC
Leszczynski, J
AF Omelchenko, Irina V.
Shishkin, Oleg V.
Gorb, Leonid
Hill, Frances C.
Leszczynski, Jerzy
TI Substituent effects and aromaticity of six-membered heterocycles
SO STRUCTURAL CHEMISTRY
LA English
DT Article
DE Aromaticity; Heteroaromaticity; Substituted heterocycles; Quantum
chemical calculations; Push-pull effect
ID PI-ELECTRON DELOCALIZATION; CONFORMATIONAL FLEXIBILITY; PYRYLIUM-SALTS;
AB-INITIO; BENZENE; RING; STATE; STABILIZATION; SILABENZENES;
ARSABENZENE
AB Structure, aromaticity, relative stability, and conformational flexibility of nitro and amino substituted monoheterocyclic analogous of benzene were studied by ab initio quantum-chemical method at MP2/aug-cc-pvDZ level of theory. Amino derivatives were found to be slightly less aromatic than nitro derivatives. Strong push-pull interactions were found in alpha- and gamma-aminochalcogenopyrylium cations and, in less extent, in alpha- and gamma-aminopyrydines. These molecules are less aromatic but more stable, as compare to their beta-isomers. All heterocycles with 3rd and 4th row heteroatoms reveal C-NO2 bond elongation accompanied by C-Heteroatom bond shortening in beta-nitro isomers, and strong inequality of two endocyclic C-Heteroatom bonds in alpha-amino isomers.
C1 [Omelchenko, Irina V.; Shishkin, Oleg V.] Natl Acad Sci Ukraine, STC Inst Single Crystals, UA-61001 Kharkov, Ukraine.
[Shishkin, Oleg V.] Kharkov Natl Univ, UA-61077 Kharkov, Ukraine.
[Gorb, Leonid] Badger Tech Serv LLC, Vicksburg, MS USA.
[Hill, Frances C.; Leszczynski, Jerzy] USA, Erdc, Vicksburg, MS 39180 USA.
[Leszczynski, Jerzy] Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA.
RP Omelchenko, IV (reprint author), Natl Acad Sci Ukraine, STC Inst Single Crystals, 60 Lenina Ave, UA-61001 Kharkov, Ukraine.
EM irina@xray.isc.kharkov.com
OI Omelchenko, Iryna/0000-0002-6882-6832
NR 81
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U1 1
U2 40
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1040-0400
J9 STRUCT CHEM
JI Struct. Chem.
PD APR
PY 2013
VL 24
IS 2
BP 725
EP 733
DI 10.1007/s11224-012-0124-x
PG 9
WC Chemistry, Multidisciplinary; Chemistry, Physical; Crystallography
SC Chemistry; Crystallography
GA 109WT
UT WOS:000316401700036
ER
PT J
AU Kang, JG
Kim, HC
Choi, CY
Nam, HY
Chae, HY
Chong, ST
Klein, TA
Ko, S
Chae, JS
AF Kang, Jun-Gu
Kim, Heung-Chul
Choi, Chang-Yong
Nam, Hyun-Young
Chae, Hee-Young
Chong, Sung-Tae
Klein, Terry A.
Ko, Sungjin
Chae, Joon-Seok
TI Molecular Detection of Anaplasma, Bartonella, and Borrelia Species in
Ticks Collected from Migratory Birds from Hong-do Island, Republic of
Korea
SO VECTOR-BORNE AND ZOONOTIC DISEASES
LA English
DT Article
DE Anaplasma; Bartonella; Borrelia; Tick-borne pathogens; Migratory bird;
Korea
ID IXODES-RICINUS TICKS; SMALL MAMMALS; LYME-DISEASE; GENETIC-VARIANTS; PCR
DETECTION; EHRLICHIA; IDENTIFICATION; JAPAN; PHAGOCYTOPHILUM; BOVIS
AB Bird migration is a recurring annual and seasonal event undertaken by more than 100 species of birds in the southeast Asian and northeast Palearctic regions that pass through or remain for short periods from April to May and September to November at Hong-do Island, Republic of Korea (ROK). A total of 212 ticks (40 Haemaphysalis flava, 12 H. longicornis, 146 Ixodes turdus, 13 I. nipponensis, and 1 I. ornithophila) were collected from 65/2,161 (3.0%) migratory birds consisting of 21 species that were captured from January, 2008, through December, 2009, as part of the Migratory Birds Center, Hong-do bird banding program for studying bird migration patterns. Adult ticks were assayed individually while larvae and nymphs were pooled (1-22 and 1-6 ticks per pool, respectively) into 31 and 65 pools, respectively. Ticks were assayed for zoonotic pathogens by PCR using 16S rRNA, heat shock protein (groEL), and internal transcribed spacer (ITS) gene primers to amplify genera specific for Anapalsma, Bartonella, and Borrelia PCR amplicons. Using the 16S rRNA-based nested PCR, A. phagocytophilum (n = 1) was detected in I. nipponensis collected from Zoothera sibirica and A. bovis (n = 1) was detected in I. turdus collected from Emberiza chrysophrys. Borrelia turdi 16S rRNA genes (n = 3) were detected in I. turdus and I. nipponensis collected from Turdus pallidus and Zoothera aurea. Borrelia spp. 16S rRNA genes (n = 4) were detected in Ixodes ticks collected from Emberiza tristrami, T. pallidus, and Z. aurea. The Bartonella grahamii ITS gene (n = 1) was detected by nested PCR assay in I. turdus collected from Z. aurea. These results provide insight into the potential role of migratory birds in the dispersal of ticks and associated tick-borne pathogens throughout their ranges in Asia.
C1 [Kang, Jun-Gu; Ko, Sungjin; Chae, Joon-Seok] Seoul Natl Univ, Res Inst Vet Sci, Lab Vet Internal Med, Seoul 151742, South Korea.
[Kang, Jun-Gu; Ko, Sungjin; Chae, Joon-Seok] Seoul Natl Univ, Coll Vet Med, Seoul 151742, South Korea.
[Kim, Heung-Chul; Chong, Sung-Tae] 168th Multifunct Med Battal, Med Detachment 5, Med Brigade 65, Unit 15247, APO, AP 96205 USA.
[Choi, Chang-Yong; Nam, Hyun-Young; Chae, Hee-Young] Natl Pk Res Inst, Migratory Birds Ctr, Shinan Gun, Jeollanam Prov, South Korea.
[Klein, Terry A.] US Army MEDDAC Korea, Med Brigade 65, APO, AP 96205 USA.
RP Chae, JS (reprint author), Seoul Natl Univ, Coll Vet Med, Lab Vet Internal Med, Seoul 151742, South Korea.
EM jschae@snu.ac.kr
OI Choi, Chang-Yong/0000-0002-4519-7957
FU National Research Foundation of Korea; Korean Government [2011-0015349];
Armed Forces Health Surveillance Center, Global Emerging Infections
Surveillance and Response System, Silver Spring, MD; National Center for
Military Intelligence, Ft. Detrick, MD
FX This research was supported by a National Research Foundation of Korea
Grant funded by the Korean Government (2011-0015349), and funding for
portions of this work was provided by the Armed Forces Health
Surveillance Center, Global Emerging Infections Surveillance and
Response System, Silver Spring, MD, and the National Center for Military
Intelligence, Ft. Detrick, MD. We thank the members of Migratory Bird
Center, National Park Research Institute, for bird tick collections
during their bird-banding surveys. We especially thank Dr. Joel Gaydos,
Global Emerging Infections Surveillance and Response System, Silver
Spring, MD, USA, for his support and constructive criticism.
NR 45
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PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1530-3667
J9 VECTOR-BORNE ZOONOT
JI Vector-Borne Zoonotic Dis.
PD APR
PY 2013
VL 13
IS 4
BP 215
EP 225
DI 10.1089/vbz.2012.1149
PG 11
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 115EM
UT WOS:000316795400002
PM 23428091
ER
PT J
AU Zhang, A
Chinnawirotpisan, P
Tang, YX
Zhou, YF
Lynch, J
Thomas, S
Kalayanarooj, S
Putnak, R
Zhang, CL
AF Zhang, Aimee
Chinnawirotpisan, Piyawan
Tang, Yuxin
Zhou, Yanfei
Lynch, Julia
Thomas, Stephen
Kalayanarooj, Siripen
Putnak, Robert
Zhang, Chunlin
TI Intra-genotypic variation of predominant genotype II strains of dengue
type-3 virus isolated during different epidemics in Thailand from 1973
to 2001
SO VIRUS GENES
LA English
DT Article
DE Dengue type-3 virus; Sequence comparison; Intra-genetic variation
ID NF-KAPPA-B; MOLECULAR EPIDEMIOLOGY; NEUROBLASTOMA-CELLS;
HEMORRHAGIC-FEVER; APOPTOSIS; BANGKOK; FLAVIVIRUSES; INHIBITION;
MECHANISMS; SEROTYPE-3
AB The prevalence of all four dengue virus (DENV) serotypes has increased dramatically in recent years in many tropical and sub-tropical countries accompanied by an increase in genetic diversity within each serotype. This expansion in genetic diversity is expected to give rise to viruses with altered antigenicity, virulence, and transmissibility. We previously demonstrated the co-circulation of multiple DENV genotypes in Thailand and identified a predominant genotype for each serotype. In this study, we performed a comparative analysis of the complete genomic sequences of 28 DENV-3 predominant genotype II strains previously collected during different DENV-3 epidemics in Thailand from 1973 to 2001 with the goal to define mutations that might correlate with virulence, transmission frequency, and epidemiological impact. The results revealed (1) 37 amino acid and six nucleotide substitutions adopted and fixed in the virus genome after their initial substitutions over nearly 30-year-sampling period, (2) the presence of more amino acid and nucleotide substitutions in recent virus isolates compared with earlier isolates, (3) six amino acid substitutions in capsid (C), pre-membrane (prM), envelope (E), and nonstructural (NS) proteins NS4B and NS5, which appeared to be associated with periods of high DENV-3 epidemic activity, (4) the highest degree of conservation in C, NS2B and the 5'-untranslated region (UTR), and (5) the highest percentage of amino acid substitutions in NS2A protein.
C1 [Zhang, Aimee] Walter Reed Army Inst Res, Sci & Engn Apprentice Program, Silver Spring, MD 20910 USA.
[Chinnawirotpisan, Piyawan; Zhang, Chunlin] US Army Med Component Armed Forces Res Inst Med S, Dept Virol, Bangkok, Thailand.
[Tang, Yuxin; Zhou, Yanfei; Lynch, Julia; Thomas, Stephen; Putnak, Robert; Zhang, Chunlin] Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD 20910 USA.
[Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand.
RP Zhang, CL (reprint author), Walter Reed Army Inst Res, Div Viral Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM chunlin.zhang@us.army.mil
FU US Military Infectious Disease Research Program at Fort Detrick,
Maryland, USA; Science and Engineering Apprentice Program (SEAP); George
Washington University/Walter Reed Army Institute of Research
FX We thank our field unit, Department of Virology, AFRIMS, Bangkok,
Thailand for sample characterization and storage as well as information
record; and the doctors and nurses of QSNICH/AFRIMS for sample
collection and clinical grading. This research was supported by the US
Military Infectious Disease Research Program at Fort Detrick, Maryland,
USA and the Science and Engineering Apprentice Program (SEAP) sponsored
by George Washington University/Walter Reed Army Institute of Research.
NR 35
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U1 1
U2 9
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0920-8569
J9 VIRUS GENES
JI Virus Genes
PD APR
PY 2013
VL 46
IS 2
BP 203
EP 218
DI 10.1007/s11262-012-0720-2
PG 16
WC Genetics & Heredity; Virology
SC Genetics & Heredity; Virology
GA 116KI
UT WOS:000316881000001
PM 22411105
ER
PT J
AU Weatherless, RA
Fedele, PD
Kehring, KL
Letowski, TR
AF Weatherless, Rachel A.
Fedele, Paul D.
Kehring, Kathy L.
Letowski, Tomasz R.
TI The Effects of Simulated Hearing Loss on Speech Recognition and Walking
Navigation
SO HUMAN FACTORS
LA English
DT Article
DE speech; hearing; walking; navigation; hearing loss; executive attention;
task interference; dual independent tasks
ID AGE-RELATED DIFFERENCES; DUAL-TASK INTERFERENCE; STOPS WALKING;
PREDICTOR; ATTENTION; TALKING; FALLS; PERFORMANCE; PEOPLE; ADULTS
AB Objective: The objective was to assess whether a concurrent but independent navigation task exacerbates the effects of hearing loss on speech recognition and whether hearing loss degrades performance of the navigation task during the concurrent but independent listening task.
Background: Navigation performance and speech comprehension both decrease when a driver follows hard-to-hear concurrent verbal instructions. It remains unknown how much both tasks would be affected when performed concurrently, if tasks were independent.
Method: Participants performed a listening task by responding to Callsign Acquisition Test (CAT) stimuli at three simulated hearing levels. For each hearing level, one trial was performed with the participant standing still and another trial was performed while navigating a path in a virtual environment using a handheld map. In one more trial, participants navigated a path with no CAT. The proportion of call signs correctly repeated and the total time required to walk the path were measured.
Results: CAT scores showed an expected negative effect of hearing loss. Concurrent navigation produced an even larger decrease in CAT score. Hearing loss caused a slight but not significant decrease in navigation task performance.
Conclusion: A person with hearing loss may communicate less effectively while walking than predicted on the basis of hearing loss alone. The hearing loss, however, does not significantly decrease walking performance in a simple navigation task.
Application: Obtained results may guide soldier performance modeling and requirements for communication systems used during physical activity when a soldier's hearing becomes compromised during dismounted combat operations.
C1 [Weatherless, Rachel A.; Fedele, Paul D.; Kehring, Kathy L.] USA, Res Lab, Aberdeen Proving Ground, MD USA.
[Letowski, Tomasz R.] USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA.
RP Fedele, PD (reprint author), ARL HRED, Attn RDRL HRS D, 520 Mulberry Point Rd, Aberdeen Proving Ground, MD 21005 USA.
EM paul.d.fedele.civ@mail.mil
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U1 0
U2 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0018-7208
J9 HUM FACTORS
JI Hum. Factors
PD APR
PY 2013
VL 55
IS 2
BP 285
EP 297
DI 10.1177/0018720812453465
PG 13
WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology,
Applied; Psychology
SC Behavioral Sciences; Engineering; Psychology
GA 112YY
UT WOS:000316632700004
PM 23691825
ER
PT J
AU Blue, M
McBride, M
Weatherless, R
Letowski, T
AF Blue, Misty
McBride, Maranda
Weatherless, Rachel
Letowski, Tomasz
TI Impact of a Bone Conduction Communication Channel on Multichannel
Communication System Effectiveness
SO HUMAN FACTORS
LA English
DT Article
DE multichannel radio communication; bone conduction; speech
intelligibility
ID BINAURAL LOUDNESS SUMMATION; SPEECH-RECEPTION THRESHOLD; SPATIAL
SEPARATION; LEVEL DIFFERENCES; AUDIO DISPLAYS; INTELLIGIBILITY; NOISE;
LOCALIZATION; RECOGNITION; HEARING
AB Objective: In this study, the impact of including a bone conduction transducer in a three-channel spatialized communication system was investigated.
Background: Several military and security forces situations require concurrent listening to three or more radio channels. In such radio systems, spatial separation between three concurrent radio channels can be achieved by delivering separate signals to the left and right earphone independently and both earphones simultaneously. This method appears to be effective; however, the use of bone conduction as one channel may provide both operational and performance benefits.
Method: Three three-channel communication systems were used to collect speech intelligibility data from 18 listeners (System 1, three loudspeakers; System 2, stereo headphones; System 3, stereo headphones and a bone conduction vibrator). Each channel presented signals perceived to originate from separate locations. Volunteers listened to three sets of competing sentences and identified a number, color, and object spoken in the target sentence. Each listener participated in three trials (one per system). Each trial consisted of 48 competing sentence sets.
Results: Systems 2 and 3 were more intelligible than System 1. Systems 2 and 3 were overall equally intelligible; however, the intelligibility of all three channels was significantly more balanced in System 3.
Conclusion: Replacing an air conduction transducer with a bone conduction transducer in a multichannel audio device can provide a more effective and balanced simultaneous monitoring auditory environment.
Application: These results have important design and implementation implications for spatial auditory communication equipment.
C1 [Blue, Misty] Wright State Univ, Dept Biomed Ind & Human Factors Engn, Dayton, OH 45435 USA.
[McBride, Maranda] N Carolina Agr & Tech State Univ, Sch Business & Econ, Greensboro, NC USA.
[Weatherless, Rachel] USA, Res Lab, Aberdeen Proving Ground, MD USA.
[Letowski, Tomasz] USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA.
RP McBride, M (reprint author), NC A&T State Univ, Dept Management, 1601 E Market St, Greensboro, NC 27411 USA.
EM mcbride@ncat.edu
NR 43
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U1 1
U2 12
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0018-7208
J9 HUM FACTORS
JI Hum. Factors
PD APR
PY 2013
VL 55
IS 2
BP 346
EP 355
DI 10.1177/0018720812460247
PG 10
WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology,
Applied; Psychology
SC Behavioral Sciences; Engineering; Psychology
GA 112YY
UT WOS:000316632700009
PM 23691830
ER
PT J
AU Miranda, LE
Killgore, KJ
AF Miranda, L. E.
Killgore, K. J.
TI Entrainment of shovelnose sturgeon by towboat navigation in the Upper
Mississippi River
SO JOURNAL OF APPLIED ICHTHYOLOGY
LA English
DT Article
ID ABUNDANCE; MORTALITY; HARVEST; FISHES; SYSTEM; RATES; POPULATIONS;
PROPELLERS
AB Estimated number of shovelnose sturgeonScaphirhynchus platorynchusimpacted annually by towboat entrainment in navigation pools of the Upper Mississippi River were compared against estimates of fishery harvest and ambient population densities to evaluate the relevance of entrainment at the population level. Mean number of sturgeon entrained per kilometer of navigation was estimated at 0.02, and mean number entrained annually considering towboat traffic was estimated at 0.38sturgeon/ha. Losses associated with entrainment were mostly lower than fishery harvest, although differences were not large. The two sources of mortality combined could potentially reduce themature adult population to a level where it no longer has the reproductive capacity to replenish itself. Thus, through a combination of entrainment and fishing mortality shovelnose sturgeon may be looming near unsustainable population levels. These estimates are preliminary considering the many uncertainties associated with quantifying entrainment and its effects. Additional research is needed not only to derive better estimates, but also to develop options for managing entrainment.
C1 [Miranda, L. E.] US Geol Survey, Mississippi Cooperat Fish & Wildlife Res Unit, Mississippi State, MS 39762 USA.
[Killgore, K. J.] USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Miranda, LE (reprint author), US Geol Survey, Mississippi Cooperat Fish & Wildlife Res Unit, POB 9691, Mississippi State, MS 39762 USA.
EM smiranda@usgs.gov
FU U.S. Army Corps of Engineers, Rock Island District
FX This study was funded by the U.S. Army Corps of Engineers, Rock Island
District, and conducted by the Environmental Laboratory, Engineer
Research and Development Center. Technical support was provided by Mark
Cornish and Thomas Keevin, U.S. Army Corps of Engineers. Q. Phelps, S.
Riffel, H. Schramm, and I. Vining provided helpful reviews. Any use of
trade, product, or firm names is for descriptive purposes only and does
not imply endorsement by the U.S. Government. Permission to publish this
document was given by the Chief of Engineers, U.S. Army Corps of
Engineers.
NR 40
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U1 0
U2 10
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0175-8659
J9 J APPL ICHTHYOL
JI J. Appl. Ichthyol.
PD APR
PY 2013
VL 29
IS 2
BP 316
EP 322
DI 10.1111/jai.12132
PG 7
WC Fisheries; Marine & Freshwater Biology
SC Fisheries; Marine & Freshwater Biology
GA 107NH
UT WOS:000316223900003
ER
PT J
AU Milillo, M
Kwak, YI
Snesrud, E
Waterman, PE
Lesho, E
McGann, P
AF Milillo, Michael
Kwak, Yoon I.
Snesrud, Erik
Waterman, Paige E.
Lesho, Emil
McGann, Patrick
TI Rapid and Simultaneous Detection of bla(KPC) and bla(NDM) by Use of
Multiplex Real-Time PCR
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID CARBAPENEMASE-PRODUCING ENTEROBACTERIACEAE; SPECTRUM-BETA-LACTAMASE;
MODIFIED HODGE TEST; RESISTANCE; BACTERIA; ISSUES; AMPC; NDM
AB The increasing incidence of carbapenem nonsusceptibility among clinically important species is of global concern. Identification of the molecular mechanisms underlying carbapenem nonsusceptibility is critical for epidemiological investigations. In this report, we describe a real-time PCR-based assay capable of simultaneously detecting bla(KPC) and bla(NDM), two of the most important carbapenemases, directly from culture in less than 90 min. The assay was validated with bla(KPC)- and bla(NDM)-carrying clinical isolates and demonstrated 100% concordance with the Carba NP test.
C1 [Milillo, Michael; Kwak, Yoon I.; Snesrud, Erik; Waterman, Paige E.; Lesho, Emil; McGann, Patrick] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA.
RP McGann, P (reprint author), Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA.
EM patrick.mcgann@amedd.army.mil
FU U.S. Army Medical Command; Defense Medical Research and Development
Program
FX We gratefully acknowledge the U.S. Army Medical Command and the Defense
Medical Research and Development Program for providing major funding for
this study. The reference strain, A. baumannii NDM2, was kindly provided
by Patrice Nordmann.
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U2 8
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD APR
PY 2013
VL 51
IS 4
BP 1247
EP 1249
DI 10.1128/JCM.03316-12
PG 3
WC Microbiology
SC Microbiology
GA 107MA
UT WOS:000316220400031
PM 23325823
ER
PT J
AU Beidleman, BA
Tighiouart, H
Schmid, CH
Fulco, CS
Muza, SR
AF Beidleman, Beth A.
Tighiouart, Hocine
Schmid, Christopher H.
Fulco, Charles S.
Muza, Stephen R.
TI Predictive Models of Acute Mountain Sickness after Rapid Ascent to
Various Altitudes
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Article
DE HYPOXIA; HYPOBARIC HYPOXIA; MIXED MODELS; ALTITUDE; ALTITUDE SICKNESS;
UNACCLIMATIZED LOWLANDERS
ID PREVALENCE; EXERCISE; ILLNESS; ALPS; DETERMINANTS; WHITNEY; SUCCESS;
EASTERN; SUMMIT; WOMEN
AB BEIDLEMAN, B. A., H. TIGHIOUART, C. H. SCHMID, C. S. FULCO, and S. R. MUZA. Predictive Models of Acute Mountain Sickness after Rapid Ascent to Various Altitudes. Med. Sci. Sports Exerc., Vol. 45, No. 4, pp. 792-800, 2013. Purpose: Despite decades of research, no predictive models of acute mountain sickness (AMS) exist, which identify the time course of AMS severity and prevalence following rapid ascent to various altitudes. Methods: Using general linear and logistic mixed models and a comprehensive database, we analyzed 1292 AMS cerebral factor scores in 308 unacclimatized men and women who spent between 4 and 48 h at altitudes ranging from 1659 to 4501 m under experimentally controlled conditions (low and high activity). Covariates included in the analysis were altitude, time at altitude, activity level, age, body mass index, race, sex, and smoking status. Results: AMS severity increased (P < 0.05) nearly twofold (i.e., 179%) for every 1000-m increase in altitude at 20 h of exposure, peaked between 18 and 22 h of exposure, and returned to initial levels by 48 h of exposure regardless of sex or activity level. Peak AMS severity scores were 38% higher (P < 0.05) in men compared with women at 20 h of exposure. High active men and women (>50% of maximal oxygen uptake for >45 min at altitude) demonstrated a 72% increase (P < 0.05) in the odds (odds ratio, 1.72; confidence interval, 1.03-3.08) of AMS compared with low active men and women. There was also a tendency (P = 0.10) for men to demonstrate greater odds of AMS (odds ratio, 1.65; confidence interval, 0.84-3.25) compared with women. Age, body mass index, race, and smoking status were not significantly associated with AMS. Conclusions: These models provide the first quantitative estimates of AMS risk over a wide range of altitudes and time points and suggest that in addition to altitude and time at altitude, high activity increases the risk of developing AMS. In addition, men demonstrated increased severity but not prevalence of AMS.
C1 [Beidleman, Beth A.; Fulco, Charles S.; Muza, Stephen R.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA.
[Tighiouart, Hocine; Schmid, Christopher H.] Tufts Med Ctr, Inst Clin Res & Hlth Policy Studies, Boston, MA USA.
RP Beidleman, BA (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA.
EM beth.beidleman@us.army.mil
OI Schmid, Christopher/0000-0002-0855-5313
FU US Army Medical Research and Materiel Command
FX The dedicated and professional efforts of Dr. Allen Cymerman, Dr. Juli
Jones, Dr. Paul Rock, Ms. Janet Staab, Mr. Vinnie Forte, Ms. Ingrid
Sils, Mr. Guy Tatum, Mr. Leonard Elliot, Mr. Rob Demes, Ms. Marie
Grunbeck, Mr. Sean Andrew, SSG Mark Kryskow, SSG Sarah Elliot, SSG
Michael Cavallo, and SPC Miguel Fernandez supporting the collection and
analysis of the data are acknowledged and greatly appreciated. The
dedication and efforts of the test volunteers in completing this study
are also acknowledged and appreciated. Funding was provided by the US
Army Medical Research and Materiel Command.
NR 42
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U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD APR
PY 2013
VL 45
IS 4
BP 792
EP 800
DI 10.1249/MSS.0b013e31827989ec
PG 9
WC Sport Sciences
SC Sport Sciences
GA 109ZK
UT WOS:000316410600024
PM 23135373
ER
PT J
AU Rhodes, NR
Tschopp, MA
Solanki, KN
AF Rhodes, N. R.
Tschopp, M. A.
Solanki, K. N.
TI Quantifying the energetics and length scales of carbon segregation to
alpha-Fe symmetric tilt grain boundaries using atomistic simulations
SO MODELLING AND SIMULATION IN MATERIALS SCIENCE AND ENGINEERING
LA English
DT Article
ID STRUCTURE-ENERGY CORRELATION; CR-1 MO STEEL; SOLUTE SEGREGATION; FCC
METALS; MOLECULAR-DYNAMICS; ATOM-PROBE; DISLOCATION NUCLEATION; CARBIDE
PRECIPITATION; TEMPER EMBRITTLEMENT; DOPANT SEGREGATION
AB Segregation of impurities to grain boundaries (GBs) plays an important role in both the stability and macroscopic behavior of polycrystalline materials. The research objective in this work is to better characterize the energetics and length scales involved with the process of solute and impurity segregation to GBs. Molecular statics simulations are used to calculate the segregation energies for carbon within multiple substitutional and interstitial GB sites over a database of 125 symmetric tilt GBs in Fe. The simulation results show that there are two energetically favorable GB segregation processes: (1) an octahedral C atom in the lattice segregating to an interstitial GB site and (2) an octahedral C atom and a vacancy in the lattice segregating to a grain boundary substitutional site. In both cases, lower segregation energies than appear in the bulk lattice were calculated. Moreover, based on segregation energies approaching bulk values, the length scale of interaction is larger for interstitial C than for substitutional C in the GB (approximate to 5 angstrom compared to approximate to 3 angstrom from center of the GB). A subsequent data reduction and statistical representation of this dataset provides critical information about the mean segregation energy and the associated energy distributions for carbon atoms as a function of distance from the grain boundary, which quantitatively informs higher scale models with energetics and length scales necessary for capturing the segregation behavior of alloying elements and impurities in Fe. The significance of this research is the development of a methodology capable of ascertaining segregation energies over a wide range of GB character (typical of that observed in polycrystalline materials), which herein has been applied to carbon segregation to substitutional and interstitial sites in a specific class of GBs in alpha-Fe.
C1 [Rhodes, N. R.; Tschopp, M. A.] Mississippi State Univ, Ctr Adv Vehicular Syst, Starkville, MS 39762 USA.
[Tschopp, M. A.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Solanki, K. N.] Arizona State Univ, Sch Engn Matter Transport & Energy, Tempe, AZ 85287 USA.
RP Rhodes, NR (reprint author), Mississippi State Univ, Ctr Adv Vehicular Syst, Starkville, MS 39762 USA.
EM mark.a.tschopp.ctr@mail.mil
RI Solanki, Kiran/E-8337-2010; Tschopp, Mark/B-1594-2008;
OI Tschopp, Mark/0000-0001-8471-5035; Solanki, Kiran/0000-0002-4385-620X
FU U.S. Department of Energy; National Energy Technology Laboratory
[DE-FC26-02OR22910]; U.S. Department of Energy's Nuclear Energy Advanced
Modeling and Simulation (NEAMS) Program at the Pacific Northwest
National Laboratory [DE-AC05-76RL01830]; Office of Naval Research
[N000141110793]; agency of the United States government
FX MAT would like to acknowledge funding under the U.S. Department of
Energy and the National Energy Technology Laboratory under Award Number
DE-FC26-02OR22910 and the U.S. Department of Energy's Nuclear Energy
Advanced Modeling and Simulation (NEAMS) Program at the Pacific
Northwest National Laboratory, which is operated by Battelle under
contract No. DE-AC05-76RL01830. KNS would like to acknowledge the
support by the Office of Naval Research under contract No.
N000141110793. This report was prepared as an account of work sponsored
by an agency of the United States government. Neither the United States
government nor any agency thereof, nor any of their employees, makes any
warranty, express or implied, or assumes any legal liability or
responsibility for the accuracy, completeness, or usefulness of any
information, apparatus, product, or process disclosed, or represents
that its use would not infringe privately owned rights. Reference herein
to any specific commercial product, process, or service by trade name,
trademark, manufacturer, or otherwise does not necessarily constitute or
imply its endorsement, recommendation, or favoring by the United States
government or any agency thereof. The views and opinions of authors
expressed herein do not necessarily state or reflect those of the United
States government or any agency thereof. Such support does not
constitute an endorsement by the Department of Energy of the work or the
views expressed herein.
NR 92
TC 25
Z9 25
U1 2
U2 41
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0965-0393
J9 MODEL SIMUL MATER SC
JI Model. Simul. Mater. Sci. Eng.
PD APR
PY 2013
VL 21
IS 3
AR 035009
DI 10.1088/0965-0393/21/3/035009
PG 21
WC Materials Science, Multidisciplinary; Physics, Applied
SC Materials Science; Physics
GA 110OD
UT WOS:000316452900009
ER
PT J
AU Hopkinson, SG
Jennings, BM
AF Hopkinson, Susan G.
Jennings, Bonnie Mowinski
TI Authors' Response to the Letter to RINAH Editor: Interruptions are
Significantly Associated With the Frequency and Severity of Medication
Errors
SO RESEARCH IN NURSING & HEALTH
LA English
DT Letter
C1 [Hopkinson, Susan G.] US Army Nurse Corps, Ctr Nursing Sci & Clin Inquiry Landstuhl Reg Med, Landstuhl, Germany.
[Jennings, Bonnie Mowinski] Emory Univ, Nell Hodgson Woodruff Sch Nursing, Atlanta, GA 30322 USA.
RP Hopkinson, SG (reprint author), US Army Nurse Corps, Ctr Nursing Sci & Clin Inquiry Landstuhl Reg Med, Landstuhl, Germany.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0160-6891
J9 RES NURS HEALTH
JI Res. Nurs. Health
PD APR
PY 2013
VL 36
IS 2
BP 117
EP 119
PG 3
WC Nursing
SC Nursing
GA 109BA
UT WOS:000316338900012
PM 23616997
ER
PT J
AU Song, HJ
Choi, KK
Lee, I
Zhao, L
Lamb, D
AF Song, Hyeongjin
Choi, K. K.
Lee, Ikjin
Zhao, Liang
Lamb, David
TI Adaptive virtual support vector machine for reliability analysis of
high-dimensional problems
SO STRUCTURAL AND MULTIDISCIPLINARY OPTIMIZATION
LA English
DT Article
DE Surrogate model; Support vector machine (SVM); Sequential sampling;
Virtual samples; Virtual support vector machine (VSVM); High-dimensional
problem
ID DESIGN OPTIMIZATION; CONTOUR ESTIMATION; MINIMIZATION; SEARCH
AB In this paper, an efficient classification methodology is developed for reliability analysis while maintaining an accuracy level similar to or better than existing response surface methods. The sampling-based reliability analysis requires only the classification information-a success or a failure-but the response surface methods provide function values on the domain as their output, which requires more computational effort. The problem is even more challenging when dealing with high-dimensional problems due to the curse of dimensionality. In the newly proposed virtual support vector machine (VSVM), virtual samples are generated near the limit state function by using an approximation method. The function values are used for approximations of virtual samples to improve accuracy of the resulting VSVM decision function. By introducing the virtual samples, VSVM can overcome the deficiency in existing classification methods where only classification values are used as their input. The universal Kriging method is used to obtain virtual samples to improve the accuracy of the decision function for highly nonlinear problems. A sequential sampling strategy that chooses new samples near the limit state function is integrated with VSVM to improve the accuracy. Examples show the proposed adaptive VSVM yields better efficiency in terms of modeling and response evaluation time and the number of required samples while maintaining similar level or better accuracy, especially for high-dimensional problems.
C1 [Song, Hyeongjin; Choi, K. K.] Univ Iowa, Dept Mech & Ind Engn, Coll Engn, Iowa City, IA 52242 USA.
[Lee, Ikjin] Univ Connecticut, Dept Mech Engn, Storrs, CT 06269 USA.
[Zhao, Liang] Schlumberger, Houston, TX 77073 USA.
[Lamb, David] USA, RDECOM TARDEC, Warren, MI 48397 USA.
RP Choi, KK (reprint author), Univ Iowa, Dept Mech & Ind Engn, Coll Engn, Iowa City, IA 52242 USA.
EM hyesong@engineering.uiowa.edu; kkchoi@engineering.uiowa.edu;
ilee@engr.uconn.edu; lzhao01@slb.com; david.lamb@us.army.mil
RI Lee, IkJin/I-4722-2013; Choi, Kyung/B-1512-2008
OI Choi, Kyung/0000-0003-2384-6220
FU ARO [W911NF-09-1-0250]; Automotive Research Center; U.S. Army TARDEC;
World Class University Program through the National Research Foundation
of Korea (NRF); Ministry of Education, Science and Technology
[R32-2008-000-10161-0]
FX The research is jointly supported by the ARO Project W911NF-09-1-0250
and the Automotive Research Center, which is sponsored by the U.S. Army
TARDEC. The research is also partially supported by the World Class
University Program through the National Research Foundation of Korea
(NRF) grant funded by the Ministry of Education, Science and Technology
(Grant Number R32-2008-000-10161-0 in 2009). These supports are greatly
appreciated.
NR 44
TC 12
Z9 13
U1 2
U2 26
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1615-147X
J9 STRUCT MULTIDISCIP O
JI Struct. Multidiscip. Optim.
PD APR
PY 2013
VL 47
IS 4
BP 479
EP 491
DI 10.1007/s00158-012-0857-6
PG 13
WC Computer Science, Interdisciplinary Applications; Engineering,
Multidisciplinary; Mechanics
SC Computer Science; Engineering; Mechanics
GA 113AO
UT WOS:000316638300001
ER
PT J
AU Yanovich, R
Evans, RK
Friedman, E
Moran, DS
AF Yanovich, Ran
Evans, Rachel K.
Friedman, Eitan
Moran, Daniel S.
TI Bone Turnover Markers Do Not Predict Stress Fracture in Elite Combat
Recruits
SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
LA English
DT Article
ID BIOCHEMICAL MARKERS; MILITARY RECRUITS; RISK-FACTORS; WOMEN
AB With bone resorption rates greater than formation, stress fracture pathogenesis plausibly involves bone remodeling imbalance. If this is the case, one would anticipate serum levels of bone turnover markers would be higher in patients with stress fractures than in those without.
We therefore asked whether: (1) bone turnover markers differ between soldiers who will or will not have stress fractures during basic training; (2) bone turnover markers change during basic training; and (3) serial bone formation or bone resorption markers differ between subjects with and without stress fractures during basic training?
We performed serial determinations of serum bone formation (bone alkaline phosphatase [BAP] and procollagen type I amino-terminal propeptide [PINP]), and resorption (tartrate-resistant acid phosphatase [TRAP5b] and cross-linked collagen telopeptide [CTx]) biomarkers, measured at 2- to 4-week intervals (during 18 weeks) in 69 male soldiers in the Israeli Defense Forces during elite basic training. Twenty-two soldiers (32%) were diagnosed with stress fractures. The mean training week at diagnosis was 8.0 +/- A 2.0 weeks.
We observed no differences in bone turnover markers between soldiers with and without stress fractures. During basic training, the mean values of all subjects for bone turnover markers (BAP, PINP, and CTx) changed in comparison to their mean levels at induction (43.9 versus 37.3 mu g/L, 110.4 versus 78.0 mu g/L, 1.4 versus 1.1 ng/mL, respectively). We found no changes in bone formation and resorption markers between subjects with and without stress fractures.
These specific bone turnover markers cannot be considered as either diagnostic or predictive tools for stress fracture detection in young male military recruits.
Level II prognostic study. See the Guidelines for Authors for a complete description of levels of evidence.
C1 [Yanovich, Ran; Moran, Daniel S.] IDF Med Corps, Inst Mil Physiol, Tel Hashomer, Israel.
[Yanovich, Ran; Moran, Daniel S.] Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel.
[Evans, Rachel K.] USA, Environm Med Res Inst, Natick, MA 01760 USA.
[Friedman, Eitan] Chaim Sheba Med Ctr, Susanne Levy Gertner Oncogenet Unit, IL-52621 Tel Hashomer, Israel.
[Friedman, Eitan] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel.
[Moran, Daniel S.] Ariel Univ, Ctr Samaria, Ariel, Israel.
RP Moran, DS (reprint author), Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel.
EM dmoran@sheba.health.gov.il
FU United States Army
FX The institution of one of the authors (DSM) has received, during the
study period, funding of USD 10,000-USD 100,000 from the United States
Army.
NR 28
TC 3
Z9 3
U1 1
U2 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0009-921X
J9 CLIN ORTHOP RELAT R
JI Clin. Orthop. Rel. Res.
PD APR
PY 2013
VL 471
IS 4
BP 1365
EP 1372
DI 10.1007/s11999-012-2727-3
PG 8
WC Orthopedics; Surgery
SC Orthopedics; Surgery
GA 097YW
UT WOS:000315510400046
PM 23239391
ER
PT J
AU Ely, BR
Sollanek, KJ
Cheuvront, SN
Lieberman, HR
Kenefick, RW
AF Ely, Brett R.
Sollanek, Kurt J.
Cheuvront, Samuel N.
Lieberman, Harris R.
Kenefick, Robert W.
TI Hypohydration and acute thermal stress affect mood state but not
cognition or dynamic postural balance
SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE Thermal sensation; Skin temperature; Profile of mood states; Postural
stability; Dehydration
ID INDUCED BODY-SWAY; HEAT-STRESS; PRESSOR INPUT; HUMAN FEET; PERFORMANCE;
DEHYDRATION; EXERCISE; HYDRATION; HYPOTHERMIA; TEMPERATE
AB Equivocal findings have been reported in the few studies that examined the impact of ambient temperature (T (a)) and hypohydration on cognition and dynamic balance. The purpose of this study was to determine the impact of acute exposure to a range of ambient temperatures (T (a) 10-40 A degrees C) in euhydration (EUH) and hypohydration (HYP) states on cognition, mood and dynamic balance. Thirty-two men (age 22 +/- A 4 years, height 1.80 +/- A 0.05 m, body mass 85.4 +/- A 10.8 kg) were grouped into four matched cohorts (n = 8), and tested in one of the four T (a) (10, 20, 30, 40 A degrees C) when EUH and HYP (-4 % body mass via exercise-heat exposure). Cognition was assessed using psychomotor vigilance, 4-choice reaction time, matching to sample, and grammatical reasoning. Mood was evaluated by profile of mood states and dynamic postural balance was tested using a Biodex Balance System. Thermal sensation (TS), core (T (core)) and skin temperature (T (sk)) were obtained throughout testing. Volunteers lost -4.1 +/- A 0.4 % body mass during HYP. T (sk) and TS increased with increasing T (a), with no effect of hydration. Cognitive performance was not altered by HYP or thermal stress. Total mood disturbance (TMD), fatigue, confusion, anger, and depression increased during HYP at all T (a). Dynamic balance was unaffected by HYP, but 10 A degrees C exposure impaired balance compared to all other T (a). Despite an increase in TMD during HYP, cognitive function was maintained in all testing environments, demonstrating cognitive resiliency in response to body fluid deficits. Dynamic postural stability at 10 A degrees C appeared to be hampered by low-grade shivering, but was otherwise maintained during HYP and thermal stress.
C1 [Ely, Brett R.; Sollanek, Kurt J.; Cheuvront, Samuel N.; Lieberman, Harris R.; Kenefick, Robert W.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA.
RP Kenefick, RW (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA.
EM robert.kenefick@us.army.mil
NR 39
TC 6
Z9 7
U1 2
U2 33
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1439-6319
J9 EUR J APPL PHYSIOL
JI Eur. J. Appl. Physiol.
PD APR
PY 2013
VL 113
IS 4
BP 1027
EP 1034
DI 10.1007/s00421-012-2506-6
PG 8
WC Physiology; Sport Sciences
SC Physiology; Sport Sciences
GA 106EI
UT WOS:000316124900023
PM 23064870
ER
PT J
AU Abrudan, J
Ramalho-Ortigao, M
O'Neil, S
Stayback, G
Wadsworth, M
Bernard, M
Shoue, D
Emrich, S
Lawyer, P
Kamhawi, S
Rowton, ED
Lehane, MJ
Bates, PA
Valenzeula, JG
Tomlinson, C
Appelbaum, E
Moeller, D
Thiesing, B
Dillon, R
Clifton, S
Lobo, NF
Wilson, RK
Collins, FH
McDowell, MA
AF Abrudan, J.
Ramalho-Ortigao, M.
O'Neil, S.
Stayback, G.
Wadsworth, M.
Bernard, M.
Shoue, D.
Emrich, S.
Lawyer, P.
Kamhawi, S.
Rowton, E. D.
Lehane, M. J.
Bates, P. A.
Valenzeula, J. G.
Tomlinson, C.
Appelbaum, E.
Moeller, D.
Thiesing, B.
Dillon, R.
Clifton, S.
Lobo, N. F.
Wilson, R. K.
Collins, F. H.
McDowell, M. A.
TI The characterization of the Phlebotomus papatasi transcriptome
SO INSECT MOLECULAR BIOLOGY
LA English
DT Review
DE sand fly; phebotomine; transcriptome
ID PROPHENOLOXIDASE-ACTIVATING SYSTEM; MOSQUITO ANOPHELES-GAMBIAE; INNATE
IMMUNE-RESPONSE; BETA-1,3-GLUCAN RECOGNITION PROTEIN; MULTIPLE SEQUENCE
ALIGNMENT; LUTZOMYIA-LONGIPALPIS; AEDES-AEGYPTI;
DROSOPHILA-MELANOGASTER; PERITROPHIC MATRIX; BOMBYX-MORI
AB As important vectors of human disease, phlebotomine sand flies are of global significance to human health, transmitting several emerging and re-emerging infectious diseases. The most devastating of the sand fly transmitted infections are the leishmaniases, causing significant mortality and morbidity in both the Old and New World. Here we present the first global transcriptome analysis of the Old World vector of cutaneous leishmaniasis, Phlebotomus papatasi (Scopoli) and compare this transcriptome to that of the New World vector of visceral leishmaniasis, Lutzomyia longipalpis. A normalized cDNA library was constructed using pooled mRNA from Phlebotomus papatasi larvae, pupae, adult males and females fed sugar, blood, or blood infected with Leishmania major. A total of 47615 generated sequences was cleaned and assembled into 17120 unique transcripts. Of the assembled sequences, 50% (8837 sequences) were classified using Gene Ontology (GO) terms. This collection of transcripts is comprehensive, as demonstrated by the high number of different GO categories. An in-depth analysis revealed 245 sequences with putative homology to proteins involved in blood and sugar digestion, immune response and peritrophic matrix formation. Twelve of the novel genes, including one trypsin, two peptidoglycan recognition proteins (PGRP) and nine chymotrypsins, have a higher expression level during larval stages. Two novel chymotrypsins and one novel PGRP are abundantly expressed upon blood feeding. This study will greatly improve the available genomic resources for P.papatasi and will provide essential information for annotation of the full genome.
C1 [Abrudan, J.; Ramalho-Ortigao, M.; Stayback, G.; Wadsworth, M.; Bernard, M.; Shoue, D.; Lobo, N. F.; Collins, F. H.; McDowell, M. A.] Univ Notre Dame, Dept Biol Sci, Eck Inst Global Hlth, Notre Dame, IN 46556 USA.
[O'Neil, S.; Emrich, S.] Univ Notre Dame, Notre Dame, IN 46556 USA.
[Lawyer, P.] NIAID, Intracellular Parasite Biol Sect, Parasit Dis Lab, NIH, Rockville, MD USA.
[Kamhawi, S.; Valenzeula, J. G.] NIAID, Vector Mol Biol Sect, Lab Malaria & Vector Res, NIH, Rockville, MD USA.
[Rowton, E. D.] Walter Reed Army Inst Res, Entomol Program, Silver Spring, MD USA.
[Lehane, M. J.] Univ Liverpool, Liverpool Sch Trop Med, Vector Grp, Liverpool L3 5QA, Merseyside, England.
[Bates, P. A.; Dillon, R.] Univ Lancaster, Div Biomed & Life Sci, Fac Hlth & Med, Lancaster, England.
[Tomlinson, C.; Appelbaum, E.; Moeller, D.; Thiesing, B.; Clifton, S.; Wilson, R. K.] Washington Univ, Genome Inst, St Louis, MO USA.
RP McDowell, MA (reprint author), Univ Notre Dame, Dept Biol Sci, Eck Inst Global Hlth, Notre Dame, IN 46556 USA.
EM mcdowell.11@nd.edu
OI Bates, Paul/0000-0001-6861-5421; Dillon, Rod/0000-0002-3551-0030
FU National Human Genome Research Institute; Defense Advanced Research
Projects Agency [W911NF0410380]; Telemedicine and Advanced Technology
Research Center [W81XWH-10-1-0085]; VectorBase [NIH/NIAID
HHSN72200900039C]; NSF MRI Grant [DBI-0420980]
FX This project was supported by the National Human Genome Research
Institute and in part by an award from the Defense Advanced Research
Projects Agency (#W911NF0410380) and Telemedicine and Advanced
Technology Research Center (#W81XWH-10-1-0085) to Mary Ann McDowell.
This project was also supported by VectorBase (NIH/NIAID
HHSN72200900039C. The assembly was performed on the Notre Dame
Biocomplexity Cluster (University of Notre Dame, Notre Dame, IN, USA)
supported in part by NSF MRI Grant No. DBI-0420980. BLAST searches were
performed on the Biocompute server at Notre Dame.
NR 109
TC 6
Z9 6
U1 1
U2 53
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1075
J9 INSECT MOL BIOL
JI Insect Mol. Biol.
PD APR
PY 2013
VL 22
IS 2
BP 211
EP 232
DI 10.1111/imb.12015
PG 22
WC Biochemistry & Molecular Biology; Entomology
SC Biochemistry & Molecular Biology; Entomology
GA 102OO
UT WOS:000315854100007
PM 23398403
ER
PT J
AU Martinez, O
Johnson, JC
Honko, A
Yen, B
Shabman, RS
Hensley, LE
Olinger, GG
Basler, CF
AF Martinez, Osvaldo
Johnson, Joshua C.
Honko, Anna
Yen, Benjamin
Shabman, Reed S.
Hensley, Lisa E.
Olinger, Gene G.
Basler, Christopher F.
TI Ebola Virus Exploits a Monocyte Differentiation Program To Promote Its
Entry
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID LAKE-VICTORIA-MARBURGVIRUS; HUMAN DENDRITIC CELLS; NIEMANN-PICK C1;
HEMORRHAGIC-FEVER; DC-SIGN; MACROPHAGE DIFFERENTIATION;
ZAIRE-EBOLAVIRUS; BLOOD MONOCYTES; MUCIN DOMAIN; VIRAL ENTRY
AB Antigen-presenting cells (APCs) are critical targets of Ebola virus (EBOV) infection in vivo. However, the susceptibility of monocytes to infection is controversial. Studies indicate productive monocyte infection, and yet monocytes are also reported to be resistant to EBOV GP-mediated entry. In contrast, monocyte-derived macrophages and dendritic cells are permissive for both EBOV entry and replication. Here, freshly isolated monocytes are demonstrated to indeed be refractory to EBOV entry. However, EBOV binds monocytes, and delayed entry occurs during monocyte differentiation. Cultured monocytes spontaneously downregulate the expression of viral entry restriction factors such as interferon-inducible transmembrane proteins, while upregulating the expression of critical EBOV entry factors cathepsin B and NPC1. Moreover, these processes are accelerated by EBOV infection. Finally, ectopic expression of NPC1 is sufficient to rescue entry into an undifferentiated, normally nonpermissive monocytic cell line. These results define the molecular basis for infection of APCs and suggest means to limit APC infection.
C1 [Martinez, Osvaldo; Yen, Benjamin; Shabman, Reed S.; Basler, Christopher F.] Icahn Sch Med Mt Sinai, New York, NY USA.
[Johnson, Joshua C.; Honko, Anna; Olinger, Gene G.] USA, Med Res Inst Infect Dis, Ft Detrick, MD USA.
[Hensley, Lisa E.] US FDA, Med Countermeasures Initiat, OCS, OCET, Silver Spring, MD USA.
RP Basler, CF (reprint author), Icahn Sch Med Mt Sinai, New York, NY USA.
EM chris.basler@mssm.edu
OI Olinger, Gene/0000-0001-7338-0292; Johnson, Joshua/0000-0002-5677-3841;
Martinez, Osvaldo/0000-0001-7335-4342; Honko, Anna/0000-0001-9165-148X;
Shabman, Reed/0000-0003-3272-3484
FU National Institutes of Health [R01AI059536, R21AI097568, AI057158]; U.S.
Army [W81XWH-10-1-0683]; NIH [5F32AI084453-02]
FX This study was supported in part by National Institutes of Health grants
R01AI059536, R21AI097568, and AI057158 (Northeast Biodefense
Center-Lipkin), U.S. Army grant W81XWH-10-1-0683 to C.F.B., and NIH
fellowship 5F32AI084453-02 to R.S.S.
NR 79
TC 15
Z9 15
U1 0
U2 27
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD APR
PY 2013
VL 87
IS 7
BP 3801
EP 3814
DI 10.1128/JVI.02695-12
PG 14
WC Virology
SC Virology
GA 103ZC
UT WOS:000315957100018
PM 23345511
ER
PT J
AU Brown, DJ
Swannack, TM
Forstner, MRJ
AF Brown, Donald J.
Swannack, Todd M.
Forstner, Michael R. J.
TI Predictive Models for Calling and Movement Activity of the Endangered
Houston Toad
SO AMERICAN MIDLAND NATURALIST
LA English
DT Article
ID DETECTION PROBABILITIES; BUFO-HOUSTONENSIS; AMPHIBIAN DECLINE;
NATIONAL-PARK; MOON PHASE; POPULATION; FRAGMENTATION; HYBRIDIZATION;
PERSPECTIVE; ABUNDANCE
AB Anuran monitoring has increased in recent years in response to global population declines. Delineating abiotic factors that influence anuran activity patterns is important for maximizing monitoring and research efficiency. The Houston toad (Bufo (Anaxyrus) houstonensis) was the first amphibian to be listed as federally endangered in the United States, and populations have continued to decline since it was listed. In this study we investigated the influence of six abiotic factors and one biotic factor on Houston toad calling activity and terrestrial movement in the Lost Pines ecoregion of Texas. Using program PRESENCE, we treated the factors as survey-specific covariates to determine their influence on detection probabilities, and thus presumably activity levels. We found that average daily absolute humidity, average daily wind speed, and presence/absence of Houston toad calling activity the previous night were important factors influencing calling activity, and average daily absolute humidity and detection/non-detection of Houston toad movement activity the previous night were important factors influencing movement activity. We also found that multiple survey years were necessary to delineate influential factors for this species, a result with implications for activity patterns of other rare anurans. The results of this study contribute to our understanding of amphibian activity patterns, and will improve the efficiency of future Houston toad research and monitoring efforts.
C1 [Brown, Donald J.; Forstner, Michael R. J.] Texas State Univ San Marcos, Dept Biol, San Marcos, TX 78666 USA.
[Swannack, Todd M.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
RP Brown, DJ (reprint author), Texas State Univ San Marcos, Dept Biol, 601 Univ Dr, San Marcos, TX 78666 USA.
EM db1300@txstate.edu
FU Boy Scouts of America; Texas Parks and Wildlife Department
[SPR-0102-191]; United States Fish and Wildlife Service [TE 039544-0]
FX We thank all of the individuals who assisted with call surveys and
trapping for this study, particularly J. Jackson and J. Bell. The Boy
Scouts of America provided funding and access to the GLR and we are
grateful for their support. Primary funding and research permits were
provided by the Texas Parks and Wildlife Department (permit
SPR-0102-191), and the United States Fish and Wildlife Service (permit
TE 039544-0). This research was approved by the Texas State
University-San Marcos Institutional Animal Care and Use Committee
(0810_0208_11). Two anonymous reviewers provided comments that greatly
enhanced the quality of this manuscript.
NR 67
TC 5
Z9 5
U1 1
U2 6
PU AMER MIDLAND NATURALIST
PI NOTRE DAME
PA UNIV NOTRE DAME, BOX 369, ROOM 295 GLSC, NOTRE DAME, IN 46556 USA
SN 0003-0031
EI 1938-4238
J9 AM MIDL NAT
JI Am. Midl. Nat.
PD APR
PY 2013
VL 169
IS 2
BP 303
EP 321
PG 19
WC Biodiversity Conservation; Ecology
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA AK1VU
UT WOS:000338206900005
ER
PT J
AU Burr, JE
Roberts, TA
Bucci, JR
AF Burr, Jean E.
Roberts, Timothy A.
Bucci, Jay R.
TI Dependent Adolescent Pregnancy Rates and Risk Factors for Pregnancy in
the Military Health Care System
SO MILITARY MEDICINE
LA English
DT Article
AB Background: We sought to determine the pregnancy rate of U.S. military-dependent adolescents enrolled in the military healthcare system. Methods: We examined the age and insurance status of dependent adolescents, ages 12 to 23, and determined the incidence of new pregnancies in the military healthcare system from 2006 to 2010 in San Antonio, Texas. Adolescents not enrolled or only recently enrolled in TRICARE Prime at the time of pregnancy were analyzed separately. A Cox-Proportional Hazards model was used to determine risk factors for pregnancy (relationship to sponsor, age, and contraceptive prescription). Results: 444 pregnancies were diagnosed among the 12,417 eligible subjects. For adolescents with continuous enrollment in TRICARE Prime, the pregnancy rate was 9.67/1,000 woman-years at risk, much lower than the national average. Cox-Proportional Hazards analysis showed age group (15-19 years), and history of oral contraceptive prescription were associated with a higher pregnancy rate. 59% of pregnancies occurred in women not enrolled or only briefly enrolled in TRICARE Prime at the time of pregnancy. Conclusion: Dependent daughters enrolled in TRICARE Prime had a very low pregnancy rate. The majority of pregnancies occurred in adolescents not enrolled in TRICARE Prime at the time of pregnancy diagnosis, suggesting many adolescents sought health insurance after pregnancy was diagnosed.
C1 [Burr, Jean E.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA.
[Roberts, Timothy A.] Naval Med Ctr San Diego, Dept Pediat, San Diego, CA 92134 USA.
[Bucci, Jay R.] Brooke Army Med Ctr, Dept Clin Invest, San Antonio, TX 78234 USA.
RP Burr, JE (reprint author), Tripler Army Med Ctr, Dept Pediat, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
NR 10
TC 1
Z9 1
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD APR
PY 2013
VL 178
IS 4
BP 412
EP 415
DI 10.7205/MILMED-D-12-00461
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7TY
UT WOS:000340805100012
PM 23707826
ER
PT J
AU Colthirst, PM
Berg, RG
DeNicolo, P
Simecek, JW
AF Colthirst, Paul M.
Berg, Rosann G.
DeNicolo, Philip
Simecek, John W.
TI Operational Cost Analysis of Dental Emergencies for Deployed US Army
Personnel During Operation Iraqi Freedom
SO MILITARY MEDICINE
LA English
DT Article
ID RATES
AB The documentation of dental emergency (DE) rates in past global conflicts has been well established; however, little is known about wartime DE costs on the battlefield. Using DEs as an example for decreased combat effectiveness, this article analyzes the cost of treating DEs in theater, both in terms of fixed and variable costs, and also highlighted the difficulties that military units experience when faced with degradation of combat manpower because of DEs. The study found that Dental-Disease and Non-Battle Injury cost the U.S. Army a total of $21.4M between July 1, 2009 and June 30, 2010, and $21.9M between July 1, 2010 and June 30, 2011. The results also revealed that approximately 32% of DE required follow-up treatment over the 2-year period, which increased the costs associated with a DE over time. Understanding the etiology and cost of DE cases, military dental practitioners will be better equipped to provide oral health instructions and preventive measures before worldwide deployments.
C1 [Colthirst, Paul M.; Berg, Rosann G.; DeNicolo, Philip] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Simecek, John W.] Naval Med Res Unit San Antonio, Ft Sam Houston, TX 78234 USA.
RP Colthirst, PM (reprint author), US Army, Inst Surg Res, 3650 Chambers Pass,Bldg 3610, Ft Sam Houston, TX 78234 USA.
FU U.S. Army Medical Research and Materiel Command Institutional Review
Board; U.S. Army Institute of Surgical Research [H-11-037]
FX The authors would especially like to thank COL Steven Eikenberg,
Department of Dental Services at the U.S. Army Medical Department Center
and School, and SFC Carlotta Trotman, NCOIC, Dental Clinic, Aberdeen
Proving Ground, for their invaluable contributions as consultants. This
study was conducted and funded under a protocol reviewed and approved by
the U.S. Army Medical Research and Materiel Command Institutional Review
Board and in accordance with the approved protocol office (U.S. Army
Institute of Surgical Research Protocol No. H-11-037).
NR 15
TC 2
Z9 2
U1 0
U2 3
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD APR
PY 2013
VL 178
IS 4
BP 427
EP 431
DI 10.7205/MILMED-D-12-00431
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7TY
UT WOS:000340805100015
PM 23707829
ER
PT J
AU Pinsker, JE
McBayne, K
Edwards, M
Jensen, K
Crudo, DF
Bauer, AJ
AF Pinsker, Jordan E.
McBayne, Krista
Edwards, Mary
Jensen, Kirk
Crudo, David F.
Bauer, Andrew J.
TI Transient Hypothyroidism in Premature Infants After Short-term Topical
Iodine Exposure: An Avoidable Risk?
SO PEDIATRICS AND NEONATOLOGY
LA English
DT Article
DE hypothyroidism; iodine; infant
AB Studies in preterm infants have shown that prolonged treatment with topical iodine (multiple doses, often over multiple days) can transiently suppress thyroid function. However, it is uncertain if topical iodine exposure for very short periods of time can cause significant changes in thyroid function. We report two cases of transient hypothyroidism in preterm infants after short-term exposure to topical iodine during surgical preparation, and review their clinical and laboratory findings before and after iodine exposure. We conclude that premature infants are at risk of developing transient hypothyroidism in response to a single, short-term exposure to topical iodine, even in iodine-sufficient geographical areas. We advise monitoring of thyroid function in these infants after iodine exposure, as treatment with levothyroxine may be needed for a limited duration to prevent the sequelae of untreated hypothyroidism. Consideration of using alternative cleansing agents is also advised. Copyright (C) 2012, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. All rights reserved.
C1 [Pinsker, Jordan E.; McBayne, Krista] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA.
[Edwards, Mary] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA.
[Jensen, Kirk; Bauer, Andrew J.] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA.
[Jensen, Kirk; Bauer, Andrew J.] Walter Reed Natl Mil Med Ctr, Dept Pediat, Bethesda, MD USA.
[Crudo, David F.] Wake Forest Univ, Bowman Gray Sch Med, Dept Pediat, Winston Salem, NC 27103 USA.
[Bauer, Andrew J.] Childrens Hosp Philadelphia, Div Endocrinol, Thyroid Ctr, Philadelphia, PA USA.
RP Pinsker, JE (reprint author), Tripler Army Med Ctr, Dept Pediat, Mail Code MCIK PE 1,Jarrett White Rd, Honolulu, HI 96859 USA.
EM jordan.pinsker@us.army.mil
OI Pinsker, Jordan/0000-0003-4080-9034
NR 26
TC 3
Z9 3
U1 0
U2 0
PU ELSEVIER TAIWAN
PI TAIPEI
PA RM N-412, 4F, CHIA HSIN BUILDING 11, NO 96, ZHONG SHAN N ROAD SEC 2,
TAIPEI, 10449, TAIWAN
SN 1875-9572
J9 PEDIATR NEONATOL
JI Pediatr. Neonatol.
PD APR
PY 2013
VL 54
IS 2
BP 128
EP 131
DI 10.1016/j.pedneo.2012.10.005
PG 4
WC Pediatrics
SC Pediatrics
GA V40NG
UT WOS:000209484700012
PM 23590958
ER
PT J
AU Fahrenfeld, N
Zoeckler, J
Widdowson, MA
Pruden, A
AF Fahrenfeld, Nicole
Zoeckler, Jeffrey
Widdowson, Mark A.
Pruden, Amy
TI Effect of biostimulants on 2,4,6-trinitrotoluene (TNT) degradation and
bacterial community composition in contaminated aquifer sediment
enrichments
SO BIODEGRADATION
LA English
DT Article
DE 2,4,6-Trinitrotoluene; Energetic compounds; Nitroaromatic; Bacterial
community; Biostimulation; Biodegradation
ID PSEUDOMONAS-PUTIDA JLR11; MICROBIAL COMMUNITY;
CLOSTRIDIUM-ACETOBUTYLICUM; SOIL; EXPLOSIVES; BIOTRANSFORMATION;
TRINITROTOLUENE; BIOREMEDIATION; BIODEGRADATION; MINERALIZATION
AB 2,4,6-Trinitrotoluene (TNT) is a toxic and persistent explosive compound occurring as a contaminant at numerous sites worldwide. Knowledge of the microbial dynamics driving TNT biodegradation is limited, particularly in native aquifer sediments where it poses a threat to water resources. The purpose of this study was to quantify the effect of organic amendments on anaerobic TNT biodegradation rate and pathway in an enrichment culture obtained from historically contaminated aquifer sediment and to compare the bacterial community dynamics. TNT readily biodegraded in all microcosms, with the highest biodegradation rate obtained under the lactate amended condition followed by ethanol amended and naturally occurring organic matter (extracted from site sediment) amended conditions. Although a reductive pathway of TNT degradation was observed across all conditions, denaturing gradient gel electrophoresis (DGGE) analysis revealed distinct bacterial community compositions. In all microcosms, Gram-negative gamma- or beta-Proteobacteria and Gram-positive Negativicutes or Clostridia were observed. A Pseudomonas sp. in particular was observed to be stimulated under all conditions. According to non-metric multidimensional scaling analysis of DGGE profiles, the microcosm communities were most similar to heavily TNT-contaminated field site sediment, relative to moderately and uncontaminated sediments, suggesting that TNT contamination itself is a major driver of microbial community structure. Overall these results provide a new line of evidence of the key bacteria driving TNT degradation in aquifer sediments and their dynamics in response to organic carbon amendment, supporting this approach as a promising technology for stimulating in situ TNT bioremediation in the subsurface.
C1 [Fahrenfeld, Nicole; Widdowson, Mark A.; Pruden, Amy] Virginia Tech, Blacksburg, VA 24061 USA.
[Zoeckler, Jeffrey] USA, Corps Engineers, Norfolk, VA 23510 USA.
RP Pruden, A (reprint author), Virginia Tech, Via Dept Civil & Environm Engn,418 Durham Hall, Blacksburg, VA 24061 USA.
EM apruden@vt.edu
FU Versar, Inc.; U.S. Army Corps of Engineers, Norfolk, Virginia
FX Funding for this work was provided by Versar, Inc. and the U.S. Army
Corps of Engineers, Norfolk, Virginia. Thanks to H. Clarkson Meredith
(Versar), Jody Smiley (VT), and Rachel Kistler (VT) for technical and
laboratory assistance.
NR 42
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U1 2
U2 66
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0923-9820
J9 BIODEGRADATION
JI Biodegradation
PD APR
PY 2013
VL 24
IS 2
BP 179
EP 190
DI 10.1007/s10532-012-9569-2
PG 12
WC Biotechnology & Applied Microbiology
SC Biotechnology & Applied Microbiology
GA 098RR
UT WOS:000315566900003
PM 22791276
ER
PT J
AU Stancoven, BW
Lee, J
Dixon, DR
McPherson, JC
Bisch, FC
Wikesjo, UME
Susin, C
AF Stancoven, B. W.
Lee, J.
Dixon, D. R.
McPherson, J. C., III
Bisch, F. C.
Wikesjoe, U. M. E.
Susin, C.
TI Effect of bone morphogenetic protein-2, demineralized bone matrix and
systemic parathyroid hormone (1-34) on local bone formation in a rat
calvaria critical-size defect model
SO JOURNAL OF PERIODONTAL RESEARCH
LA English
DT Article
DE bone formation; demineralized bone matrix; PTH; rhBMP-2; tissue
engineering
ID FREEZE-DRIED BONE; ALVEOLAR RIDGE AUGMENTATION; TISSUE OCCLUSION;
PARTICLE-SIZE; REGENERATION; REPAIR; ALLOGRAFT; RHBMP-2; INDUCE; GROWTH
AB Aim To determine the potential of recombinant human bone morphogenetic protein-2 (rhBMP-2) soak-loaded on to an absorbable collagen sponge (ACS) to induce local bone formation compared with the clinical reference demineralized bone matrix (DBM) and to investigate potential additive/synergistic effects of exogenous parathyroid hormone (PTH). Methods Critical-size (8mm), through-through calvaria osteotomy defects in 160 adult male SpragueDawley rats were randomized to receive one of eight interventions: rhBMP-2/ACS, DBM, ACS, or serve as controls (empty defects) combined or not with systemic PTH. Ten animals from each group were followed for 4 and 8wks for radiographic and histometric analysis. Multivariable analysis was used to assess the effect of experimental intervention and healing time on local bone formation. Results In the multivariable analysis, rhBMP-2/ACS exhibited significantly greater histologic bone formation than control (+/- SE: 54.76 +/- 5.85, p<0.001) and ACS (+/- SE: 9.14 +/- 3.31, p=0.007) whereas DBM showed significantly less bone formation than control (+/- SE: 32.32 +/- 8.23, p<0.001). Overall, PTH did not show a significant effect on bone formation (+/- SE: 2.72 +/- 6.91, p=0.70). No significant differences in histological defect closure were observed between 4 and 8wks for all but the control group without PTH. Conclusion rhBMP-2/ACS significantly stimulates local bone formation whereas bone formation appears significantly limited by DBM. Systemic application of PTH provided no discernible additive/synergistic effects on local bone formation.
C1 [Stancoven, B. W.; Lee, J.; Wikesjoe, U. M. E.; Susin, C.] Georgia Hlth Sci Univ, LAPCR, Dept Periodont, Augusta, GA USA.
[Stancoven, B. W.; Lee, J.; Wikesjoe, U. M. E.; Susin, C.] Georgia Hlth Sci Univ, LAPCR, Dept Oral Biol, Augusta, GA USA.
[Stancoven, B. W.; Dixon, D. R.; Bisch, F. C.] USA, Adv Educ, Program Periodont, Ft Gordon, GA USA.
[Dixon, D. R.] So Reg Dent Command, Dent Res, Ft Gordon, GA USA.
[McPherson, J. C., III] USA, Dept Clin Invest, Ft Gordon, GA USA.
RP Susin, C (reprint author), Georgia Hlth Sci Univ Coll Dent Med, Lab Appl Periodontal & Craniofacial Regenerat, 1120 15th St AD-1432, Augusta, GA 30912 USA.
EM csusin@georgiahealth.edu
RI Susin, Cristiano/B-9822-2008; Wikesjo, Ulf/A-4159-2009
OI Wikesjo, Ulf/0000-0003-1607-0583
FU US Army Dental Command; Ft Gordon DEN-TAC; 3M Non-Tenured Faculty Grant,
St. Paul, MN, USA; Nobel Biocare AB, Goteborg, Sweden
FX Research funding for this study was supported by the US Army Dental
Command and the Ft Gordon DEN-TAC. Dr. Susin was supported in part by a
3M Non-Tenured Faculty Grant, St. Paul, MN, USA. Dr. Wikesjo was
supported in part by a grant from Nobel Biocare AB, Goteborg, Sweden.
NR 40
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Z9 11
U1 0
U2 13
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3484
J9 J PERIODONTAL RES
JI J. Periodont. Res.
PD APR
PY 2013
VL 48
IS 2
BP 243
EP 251
DI 10.1111/jre.12001
PG 9
WC Dentistry, Oral Surgery & Medicine
SC Dentistry, Oral Surgery & Medicine
GA 097JK
UT WOS:000315469600014
PM 22970744
ER
PT J
AU Liu, DM
Xiong, YH
Li, Y
Topping, TD
Zhou, YZ
Haines, C
Paras, J
Martin, D
Kapoor, D
Schoenung, JM
Lavernia, EJ
AF Liu, Dongming
Xiong, Yuhong
Li, Ying
Topping, Troy D.
Zhou, Yizhang
Haines, Chris
Paras, Joseph
Martin, Darold
Kapoor, Deepak
Schoenung, Julie M.
Lavernia, Enrique J.
TI Spark Plasma Sintering of Nanostructured Aluminum: Influence of Tooling
Material on Microstructure
SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND
MATERIALS SCIENCE
LA English
DT Article
ID MECHANICAL-PROPERTIES; GRAIN-GROWTH; PURE ALUMINUM; POWDER; AL;
PRESSURE; ALLOY; EVOLUTION; COPPER
AB The influence of tooling material, i.e., graphite and WC-Co, on the microstructure of a spark plasma sintering (SPS) consolidated, nanostructured aluminum alloy is studied in this paper. The results show that tooling selection influences microstructure evolution, independent of process parameters. The influence of tooling on microstructure is rationalized on the basis of the following factors: heating rate, electrical current density, localized heating, and imposed pressure. A theoretic framework, based on the physical properties of graphite and WC-Co, is formulated to explain the observed behavior.
C1 [Liu, Dongming] Shandong Univ, Dept Mat Sci & Engn, Jinan 250061, Peoples R China.
[Xiong, Yuhong; Li, Ying; Topping, Troy D.; Zhou, Yizhang; Schoenung, Julie M.; Lavernia, Enrique J.] Univ Calif Davis, Dept Chem Engn & Mat Sci, Davis, CA 95616 USA.
[Haines, Chris; Paras, Joseph; Martin, Darold; Kapoor, Deepak] TACOM ARDEC, USA, Picatinny Arsenal, NJ 07806 USA.
RP Lavernia, EJ (reprint author), Univ Calif Davis, Dept Chem Engn & Mat Sci, Davis, CA 95616 USA.
EM lavernia@ucdavis.edu
RI Lavernia, Enrique/I-6472-2013; Li, Ying/G-3908-2010
OI Lavernia, Enrique/0000-0003-2124-8964; Li, Ying/0000-0003-3738-9307
FU US Army TACOM-ARDEC [W05QKN-09-C-118]; Office of Naval Research
[N00014-07-1-0745]; Young Scientist Foundation of Shandong Province,
China [BS2009CL043]; innovation foundation of Shandong University
[2012TS032]
FX This paper is based upon work supported by the US Army TACOM-ARDEC under
contract No. W05QKN-09-C-118 and the Office of Naval Research with grant
No. N00014-07-1-0745. Part of D. Liu's work is also supported by the
Young Scientist Foundation of Shandong Province, China (No.
BS2009CL043), and the innovation foundation of Shandong University
(2012TS032).
NR 40
TC 6
Z9 6
U1 2
U2 37
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1073-5623
J9 METALL MATER TRANS A
JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci.
PD APR
PY 2013
VL 44A
IS 4
BP 1908
EP 1916
DI 10.1007/s11661-012-1533-6
PG 9
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA 096VV
UT WOS:000315433700032
ER
PT J
AU Cervenka, MC
Corines, J
Boatman-Reich, DF
Eloyan, A
Sheng, X
Franaszczuk, PJ
Crone, NE
AF Cervenka, Mackenzie Carpenter
Corines, James
Boatman-Reich, Dana Frances
Eloyan, Ani
Sheng, Xi
Franaszczuk, Piotr Julian
Crone, Nathan Earl
TI Electrocorticographic functional mapping identifies human cortex
critical for auditory and visual naming
SO NEUROIMAGE
LA English
DT Article
DE Language mapping; Epilepsy surgery; High gamma; Electrocorticography;
Electrocortical stimulation; Surgical outcome
ID EVENT-RELATED RESPONSES; CORTICAL STIMULATION; GAMMA ACTIVITY; MATCHING
PURSUIT; VERB GENERATION; TEMPORAL CORTEX; WORD PRODUCTION; LANGUAGE;
SPEECH; TIME
AB More comprehensive, and efficient, mapping strategies are needed to avoid post-operative language impairments in patients undergoing epilepsy surgery. Conservative resection of dominant anterior frontal or temporal cortex frequently results in post-operative naming deficits despite standard pre-operative electrocortical stimulation mapping of visual object (picture) naming. Naming to auditory description may better simulate word retrieval in human conversation but is not typically tested, in part due to the time demands of electrocortical stimulation mapping. Electrocorticographic high gamma (60-150 Hz) activity, recorded simultaneously through the same electrodes used for stimulation mapping, has recently been used to map brain function more efficiently, and has at times predicted deficits not anticipated based on stimulation mapping alone. The present study investigated electrocorticographic mapping of visual object naming and auditory descriptive naming within conservative dominant temporal or frontal lobe resection boundaries in 16 patients with 933 subdural electrodes implanted for epilepsy surgery planning. A logistic regression model showed that electrodes within traditional conservative dominant frontal or temporal lobe resection boundaries were significantly more likely to record high gamma activity during auditory descriptive naming than during visual object naming. Eleven patients ultimately underwent resection and 7 demonstrated post-operative language deficits not anticipated based on electrocortical stimulation mapping alone. Four patients with post-operative deficits underwent a resection that included sites where high gamma activity was observed during naming. These findings indicate that electrocorticographic mapping of auditory descriptive naming may reduce the risk of permanent post-operative language deficits following dominant temporal or frontal resection. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Cervenka, Mackenzie Carpenter; Corines, James; Boatman-Reich, Dana Frances; Franaszczuk, Piotr Julian; Crone, Nathan Earl] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21287 USA.
[Eloyan, Ani] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Biostat, Baltimore, MD USA.
[Sheng, Xi] George Washington Univ, Dept Psychol, Washington, DC 20052 USA.
[Franaszczuk, Piotr Julian] USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA.
RP Cervenka, MC (reprint author), Johns Hopkins Univ, Sch Med, Dept Neurol, 600 N Wolfe St,Meyer 2-147, Baltimore, MD 21287 USA.
EM mcerven1@jhmi.edu
RI Franaszczuk, Piotr/B-6532-2008
OI Franaszczuk, Piotr/0000-0002-5166-4224
FU National Institutes of Neurological Disorders and Stroke [NS40596];
National Institutes of Health-National Institute of Deafness and Other
Communication Disorders [DC010028, DC005645]; Epilepsy Foundation
FX This work was supported by the National Institutes of Neurological
Disorders and Stroke [NS40596 to N.E.C.]; National Institutes of
Health-National Institute of Deafness and Other Communication Disorders
[DC010028 and DC005645 to D.F.B.]; and the Epilepsy Foundation [Research
and Training Fellowships for Clinicians to M.C.C.].
NR 58
TC 27
Z9 27
U1 2
U2 19
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1053-8119
J9 NEUROIMAGE
JI Neuroimage
PD APR 1
PY 2013
VL 69
BP 267
EP 276
DI 10.1016/j.neuroimage.2012.12.037
PG 10
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA 085PX
UT WOS:000314627800025
PM 23274183
ER
PT J
AU Hodges, SE
McCormick, SJ
AF Hodges, Steven E.
McCormick, Steven J.
TI Fire Extinguishing Agents for Protection of Occupied Spaces in Military
Ground Vehicles
SO FIRE TECHNOLOGY
LA English
DT Article
DE Military vehicle fire protection; Fire extinguishing agents; Explosion
protection of occupied areas; AFES; Clean agents; Halon 1301; FM-200BC;
HFC-227BC; Novec 1230; FK-5-1-12
AB Historically the US Army used Halon 1301 (bromotrifluoromethane), a chemical with high ozone depletion potential (ODP), to protect the crews of armored vehicles from the effects of peacetime and combat fires. Since the phase-out of Halon production the US Army has directed that zero ODP materials be used wherever possible. Subsequently, major new vehicle platforms have been deployed with automatic fire extinguishing systems (AFES) that rely on HFC-227BC, a zero-ODP-agent blend of HFC-227ea (heptafluoropropane) and sodium-bicarbonate-based dry chemical. Unfortunately, hydrofluorocarbons (HFCs) generally have high global warming potential (GWP)-thousands of times that of carbon dioxide on a weight basis. Hence, as part of a larger effort to reduce its carbon footprint, US Army Program Managers have asked that fire extinguishing agents that are more environmentally friendly be evaluated as part of ongoing vehicle modernization efforts. Several agents were investigated, including FK-5-1-12, water with additives, and dry chemicals. This report describes the findings of more than 150 live-fire tests using nine agents and four extinguisher technologies. The basic conclusion is that no alternate agent can yet be considered to be a practical replacement for Halon 1301 or HFC-227BC for this application. However, a blend of Halon 1301 and dry chemical has been found to be about twice as effective as Halon 1301 alone. Thus, pending confirmation tests on vehicles, it may be feasible to use less Halon in legacy systems without compromising fire protection performance.
C1 [Hodges, Steven E.] USA, TARDEC, Santa Barbara, CA 93105 USA.
[McCormick, Steven J.] USA, TARDEC Ground Syst Survivabil, Warren, MI 48397 USA.
RP Hodges, SE (reprint author), USA, TARDEC, 2979 La Combadura, Santa Barbara, CA 93105 USA.
EM steven.e.hodges1.ctr@mail.mil
FU Ground Systems Survivability (GSS) at TARDEC
FX This program was funded by Ground Systems Survivability (GSS) at TARDEC
and is a continuation of the work reported previously [28]. Valuable
support and discussions with Ron Sheinson of the Naval Research
Laboratory and Joe Senecal of United Technology Fire & Security are
gratefully acknowledged. The excellent support of Aberdeen Test Center
was crucial to completing these tests.
NR 25
TC 3
Z9 3
U1 0
U2 75
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0015-2684
J9 FIRE TECHNOL
JI Fire Technol.
PD APR
PY 2013
VL 49
IS 2
BP 379
EP 394
DI 10.1007/s10694-012-0271-z
PG 16
WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary
SC Engineering; Materials Science
GA 072CI
UT WOS:000313645600008
ER
PT J
AU Naik, RS
Liu, WY
Saxena, A
AF Naik, Ramachandra S.
Liu, Weiyi
Saxena, Ashima
TI Development and validation of a simple assay for the determination of
cholinesterase activity in whole blood of laboratory animals
SO JOURNAL OF APPLIED TOXICOLOGY
LA English
DT Article
DE cholinesterase activity; butyrylcholinesterase; acetylcholinesterase;
animal whole blood; cholinesterase inhibitors; ethopropazine;
(-)-huperzine A
ID HUMAN SERUM BUTYRYLCHOLINESTERASE; ACETYLCHOLINESTERASE ACTIVITY; SARIN
VAPOR; SOMAN; EXPOSURE; PLASMA; PRETREATMENT; PROPHYLAXIS; SPECIFICITY;
INHIBITION
AB Current methods for measuring acetylcholinesterase (AChE) activities in whole blood use butyrylcholinesterase (BChE)-selective inhibitors. However, the poor selectivity of these inhibitors results in the inhibition of AChE activity to some degree, leading to errors in reported values. The goal of this study was to develop and validate a simple assay for measuring AChE and BChE activities in whole blood from humans as well as experimental animals. Blood was fractionated into plasma and erythrocytes, and cholinesterase activities were titrated against ethopropazine and (-)-huperzine A to determine the lowest concentration of ethopropazine that inhibited BChE completely without affecting AChE activity and the lowest concentration of (-)-huperzine A that inhibited AChE completely without interfering with BChE activity. Results indicate that 20?mu m ethopropazine can be successfully used for the accurate measurement of AChE activity in blood from humans as well as animals. Use of (-)-huperzine A is not required for measuring BChE activity in normal or exposed blood samples. The method was validated for blood from several animal species, including mice, rats, guinea pigs, dogs, minipigs, and African green, cynomolgus and rhesus monkeys. This method is superior to all reported methods, does not require the separation of erythrocyte and plasma fractions, and is suitable for measuring cholinesterase activities in fresh or frozen blood from animals that were exposed to nerve agents or those that were administered high doses of BChE. The method is simple, direct, reproducible, and reliable and can easily be adapted for high-throughput screening of blood samples. Published 2012. This article is a US Government work and is in the public domain in the USA.
C1 [Naik, Ramachandra S.; Liu, Weiyi; Saxena, Ashima] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA.
RP Naik, RS (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM Ramachandra.Naik@us.army.mil
FU Defense Threat Reduction Agency
FX This work was supported by funding from the Defense Threat Reduction
Agency. The authors wish to thank Ms Amy Michels for assistance in
preparation of the manuscript, Russell Glorioso and Anjana Mohanty for
their technical assistance, and Dr Robert diTargiani and Mr Donald M.
Maxwell for conducting in vitro exposures of human blood samples to
sarin and VX at the United States Army Medical Research Institute of
Chemical Defense, Aberdeen Proving Ground, MD, USA.
NR 44
TC 6
Z9 7
U1 4
U2 60
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0260-437X
J9 J APPL TOXICOL
JI J. Appl. Toxicol.
PD APR
PY 2013
VL 33
IS 4
BP 290
EP 300
DI 10.1002/jat.2730
PG 11
WC Toxicology
SC Toxicology
GA 080DB
UT WOS:000314220300006
PM 22407886
ER
PT J
AU Darrah, M
Fuller, E
Munasinghe, T
Duling, K
Gautam, M
Wathen, M
AF Darrah, Marjorie
Fuller, Edgar
Munasinghe, Thilanka
Duling, Kristin
Gautam, Mridul
Wathen, Mitchell
TI Using Genetic Algorithms for Tasking Teams of Raven UAVs
SO JOURNAL OF INTELLIGENT & ROBOTIC SYSTEMS
LA English
DT Article
DE UAVs; Genetic algorithms; Cooperative control; Tasking algorithms
AB Control of multiple unmanned aerial vehicles is of importance given that so many have been deployed in the field. This work discusses how genetic algorithms (GA) have been applied to the cooperative tasking of the AeroVironment's Raven unmanned aerial vehicle (UAV) engaged in an intelligence, reconnaissance, and surveillance (ISR) mission. Mission assumptions, development of the GA, the method used to test for convergence, and the outcome of preliminary testing are all discussed.
C1 [Darrah, Marjorie; Fuller, Edgar; Munasinghe, Thilanka; Duling, Kristin; Gautam, Mridul] W Virginia Univ, Morgantown, WV 26506 USA.
[Wathen, Mitchell] USA, Res Lab, Adelphi, MD USA.
RP Darrah, M (reprint author), W Virginia Univ, Morgantown, WV 26506 USA.
EM mdarrah@math.wvu.edu
OI Fuller, Edgar/0000-0003-4130-090X
FU U.S Army Research Laboratory [W911NF-10-2-0110]
FX This work has been supported by U.S Army Research Laboratory under
Cooperative Agreement no. W911NF-10-2-0110.
NR 24
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U1 3
U2 39
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0921-0296
EI 1573-0409
J9 J INTELL ROBOT SYST
JI J. Intell. Robot. Syst.
PD APR
PY 2013
VL 70
IS 1-4
SI SI
BP 361
EP 371
DI 10.1007/s10846-012-9696-3
PG 11
WC Computer Science, Artificial Intelligence; Robotics
SC Computer Science; Robotics
GA 058OE
UT WOS:000312642600025
ER
PT J
AU Cao, XY
Chappell, MA
Schimmelmann, A
Mastalerz, M
Li, Y
Hu, WG
Mao, JD
AF Cao, Xiaoyan
Chappell, Mark A.
Schimmelmann, Arndt
Mastalerz, Maria
Li, Yuan
Hu, Weiguo
Mao, Jingdong
TI Chemical structure changes in kerogen from bituminous coal in response
to dike intrusions as investigated by advanced solid-state C-13 NMR
spectroscopy
SO INTERNATIONAL JOURNAL OF COAL GEOLOGY
LA English
DT Article
DE Kerogen; Bituminous coal; Dike intrusion; NMR
ID NUCLEAR-MAGNETIC-RESONANCE; IGNEOUS INTRUSION; VITRINITE REFLECTANCE;
ORGANIC-MATTER; ILLINOIS BASIN; PITKIN COUNTY; WHOLE-COAL; CPMAS NMR;
GEOCHEMISTRY; METAMORPHISM
AB Coal maturation due to igneous intrusions offers the ideal opportunity to study the chemical-structural evolution of rapidly heated coal. Variations in the chemical structures of kerogens from high volatile bituminous coal near two igneous dike intrusions in the Illinois Basin were characterized in detail by advanced solid-state C-13 nuclear magnetic resonance (NMR) spectroscopy. With decreasing distance to dike contacts and increasing thermal maturity (vitrinite reflectance R-o from 0.62% to 5.03%), the new insights into the chemical structural changes in coal kerogens include (i) the C(CH2)C groups removed faster than CCH3 groups, suggesting that the major cleavage of aliphatics should not occur at aryl rings, (ii) a progressive decrease of the relative abundance of protonated aromatic carbons, possibly due to replacement of aromatic hydrogens by aryl groups via cross-linking, and (iii) an increase in the aromatic cluster size, in addition to the well established changes of the elimination of aliphatics and aromatic C-O groups and an increase in aromaticity. For the first time the growth of aromatic cluster sizes with increasing maturity was quantitatively estimated. Another novel finding is that coal kerogen (kerogen #22) directly at the contact with the large dike retained considerable aliphatic components with olefinic and COO groups. These aliphatic components could have been entrapped and failed to diffuse out rapidly enough because intense and very fast heating rendered this kerogen partially fluidized. Our advanced solid-state NMR techniques provided deep insights into the structural changes in kerogen from bituminous coal in response to dike intrusions which cannot be achievable using routine C-13 cross polarization/magic angle spinning technique. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Cao, Xiaoyan; Li, Yuan; Mao, Jingdong] Old Dominion Univ, Dept Chem & Biochem, Norfolk, VA 23529 USA.
[Chappell, Mark A.] USA, Corps Engineers, Environm Lab, Vicksburg, MS 39180 USA.
[Schimmelmann, Arndt] Indiana Univ, Dept Geol Sci, Bloomington, IN 47405 USA.
[Mastalerz, Maria] Indiana Univ, Indiana Geol Survey, Bloomington, IN 47405 USA.
[Hu, Weiguo] Univ Massachusetts, Dept Polymer Sci & Engn, Amherst, MA 01003 USA.
RP Mao, JD (reprint author), Old Dominion Univ, Dept Chem & Biochem, 4541 Hampton Blvd, Norfolk, VA 23529 USA.
EM jmao@odu.edu
RI Cao, Xiaoyan/E-3492-2012
OI Cao, Xiaoyan/0000-0001-7571-6482
FU National Science Foundation [EAR-0843996, CBET-0853950]; Petroleum
Research Fund [46373-G2, 44815-AC2]; U.S. Department of Energy, Basic
Energy Research [DEFG02-00ER15032]
FX This research was supported by National Science Foundation grants
EAR-0843996 and CBET-0853950, and by the Donors of the Petroleum
Research Fund, administered by the American Chemical Society, grant
46373-G2. Arndt Schimmelmann and Maria Mastalerz acknowledge support
from the U.S. Department of Energy, Basic Energy Research Grant
DEFG02-00ER15032, and from the Donors of the Petroleum Research Fund,
administered by the American Chemical Society, grant 44815-AC2.
NR 53
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U1 4
U2 34
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-5162
J9 INT J COAL GEOL
JI Int. J. Coal Geol.
PD MAR 30
PY 2013
VL 108
SI SI
BP 53
EP 64
DI 10.1016/j.coal.2012.05.002
PG 12
WC Energy & Fuels; Geosciences, Multidisciplinary
SC Energy & Fuels; Geology
GA 110GD
UT WOS:000316429700008
ER
PT J
AU Reid, GA
Chilukuri, N
Darvesh, S
AF Reid, G. A.
Chilukuri, N.
Darvesh, S.
TI BUTYRYLCHOLINESTERASE AND THE CHOLINERGIC SYSTEM
SO NEUROSCIENCE
LA English
DT Article
DE cholinesterases; acetylcholinesterase; pseudocholinesterase; choline
acetyltransferase; 129S1/SvImJ mice; acetylcholine
ID SPINAL-CORD; HYDROLYZE ACETYLCHOLINE; HUMAN THALAMUS; BRAIN-STEM;
RAT-BRAIN; ACETYLTRANSFERASE; NEURONS; MOUSE; LOCALIZATION; MICE
AB The cholinergic system plays important roles in neurotransmission in both the peripheral and central nervous systems. The cholinergic neurotransmitter acetylcholine is synthesized by choline acetyltransferase (ChAT) and its action terminated by acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The predominance of AChE has focused much attention on understanding the relationship of this enzyme to ChAT-positive cholinergic neurons. However, there is ample evidence that BuChE also plays an important role in cholinergic regulation. To elucidate the relationship of BuChE to neural elements that are producing acetylcholine, the distribution of this enzyme was compared to that of ChAT in the mouse CNS. Brain tissues from 129S1/SvImJ mice were stained for BuChE and ChAT using histochemical, immunohistochemical and immunofluorescent techniques. Both BuChE and ChAT were found in neural elements throughout the CNS. BuChE staining with histochemistry and immunohistochemistry produced the same distribution of labeling throughout the brain and spinal cord. Immunofluorescent double labeling demonstrated that many nuclei in the medulla oblongata, as well as regions of the spinal cord, had neurons that contained both BuChE and ChAT. BuChE-positive neurons without ChAT were found in close proximity with ChAT-positive neuropil in areas such as the thalamus and amygdala. BuChE-positive neuropil was also found closely associated with ChAT-positive neurons, particularly in tegmental nuclei of the pons. These observations provide further neuroanatomical evidence of a role for BuChE in the regulation of acetylcholine levels in the CNS. (C) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.
C1 [Reid, G. A.; Darvesh, S.] Dalhousie Univ, Dept Med Neurosci, Halifax, NS B3H 2E1, Canada.
[Chilukuri, N.] USA, Div Res, Physiol & Immunol Branch, Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
[Darvesh, S.] Dalhousie Univ, Dept Med Neurol & Geriatr Med, Halifax, NS B3H 2E1, Canada.
RP Darvesh, S (reprint author), Dalhousie Univ, Dept Med Neurosci, Room 1308,Camp Hill Vet Mem,5955 Vet Mem Lane, Halifax, NS B3H 2E1, Canada.
EM sultan.darvesh@dal.ca
FU Canadian Institutes of Health Research; Capital District Health
Authority Research Fund; Nova Scotia Health Research Foundation; Faculty
of Medicine (Clinician-Scientist Program); Dalhousie University
Department of Medicine (University Internal Medicine Research Fund);
Dalhousie Medical Research Foundation; Defense Threat Reduction Agency
(DTRA), Joint Science and Technology Office, Medical ST Division
FX This work was supported in part by Canadian Institutes of Health
Research, Capital District Health Authority Research Fund, Nova Scotia
Health Research Foundation, Faculty of Medicine (Clinician-Scientist
Program), Dalhousie University Department of Medicine (University
Internal Medicine Research Fund) and Dalhousie Medical Research
Foundation (S.D.) and Defense Threat Reduction Agency (DTRA), Joint
Science and Technology Office, Medical S&T Division (N.C.). We would
like to thank Professor Earl Martin for critically reviewing this
manuscript.
NR 48
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U1 0
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
J9 NEUROSCIENCE
JI Neuroscience
PD MAR 27
PY 2013
VL 234
BP 53
EP 68
DI 10.1016/j.neuroscience.2012.12.054
PG 16
WC Neurosciences
SC Neurosciences & Neurology
GA 111OG
UT WOS:000316530000006
PM 23305761
ER
PT J
AU Bethell, D
Saunders, D
Jongkaewwattana, A
Kramyu, J
Thitithayanont, A
Wiboon-ut, S
Yongvanitchit, K
Limsalakpetch, A
Kum-Arb, U
Uthaimongkol, N
Garcia, JM
Timmermans, AE
Peiris, M
Thomas, S
Engering, A
Jarman, RG
Mongkolsirichaikul, D
Mason, C
Khemnu, N
Tyner, SD
Fukuda, MM
Walsh, DS
Pichyangkul, S
AF Bethell, Delia
Saunders, David
Jongkaewwattana, Anan
Kramyu, Jarin
Thitithayanont, Arunee
Wiboon-ut, Suwimon
Yongvanitchit, Kosol
Limsalakpetch, Amporn
Kum-Arb, Utaiwan
Uthaimongkol, Nichapat
Garcia, Jean Michel
Timmermans, Ans E.
Peiris, Malik
Thomas, Stephen
Engering, Anneke
Jarman, Richard G.
Mongkolsirichaikul, Duangrat
Mason, Carl
Khemnu, Nuanpan
Tyner, Stuart D.
Fukuda, Mark M.
Walsh, Douglas S.
Pichyangkul, Sathit
TI Evaluation of In Vitro Cross-Reactivity to Avian H5N1 and Pandemic H1N1
2009 Influenza Following Prime Boost Regimens of Seasonal Influenza
Vaccination in Healthy Human Subjects: A Randomised Trial
SO PLOS ONE
LA English
DT Article
ID T-CELLS; NEURAMINIDASE ANTIBODY; A VIRUS; MF59-ADJUVANTED INFLUENZA;
VACCINES; LIVE; PROTECTION; RESPONSES; IMMUNITY; MICE
AB Introduction: Recent studies have demonstrated that inactivated seasonal influenza vaccines (IIV) may elicit production of heterosubtypic antibodies, which can neutralize avian H5N1 virus in a small proportion of subjects. We hypothesized that prime boost regimens of live and inactivated trivalent seasonal influenza vaccines (LAIV and IIV) would enhance production of heterosubtypic immunity and provide evidence of cross-protection against other influenza viruses.
Methods: In an open-label study, 26 adult volunteers were randomized to receive one of four vaccine regimens containing two doses of 2009-10 seasonal influenza vaccines administered 8 (61) weeks apart: 2 doses of LAIV; 2 doses of IIV; LAIV then IIV; IIV then LAIV. Humoral immunity assays for avian H5N1, 2009 pandemic H1N1 (pH1N1), and seasonal vaccine strains were performed on blood collected pre-vaccine and 2 and 4 weeks later. The percentage of cytokine-producing T-cells was compared with baseline 14 days after each dose.
Results: Subjects receiving IIV had prompt serological responses to vaccine strains. Two subjects receiving heterologous prime boost regimens had enhanced haemagglutination inhibition (HI) and neutralization (NT) titres against pH1N1, and one subject against avian H5N1; all three had pre-existing cross-reactive antibodies detected at baseline. Significantly elevated titres to H5N1 and pH1N1 by neuraminidase inhibition (NI) assay were observed following LAIV-IIV administration. Both vaccines elicited cross-reactive CD4+ T-cell responses to nucleoprotein of avian H5N1 and pH1N1. All regimens were safe and well tolerated.
Conclusion: Neither homologous nor heterologous prime boost immunization enhanced serum HI and NT titres to 2009 pH1N1 or avian H5N1 compared to single dose vaccine. However heterologous prime-boost vaccination did lead to in vitro evidence of cross-reactivity by NI; the significance of this finding is unclear. These data support the strategy of administering single dose trivalent seasonal influenza vaccine at the outset of an influenza pandemic while a specific vaccine is being developed.
C1 [Bethell, Delia; Saunders, David; Yongvanitchit, Kosol; Limsalakpetch, Amporn; Kum-Arb, Utaiwan; Uthaimongkol, Nichapat; Timmermans, Ans E.; Engering, Anneke; Tyner, Stuart D.; Fukuda, Mark M.; Walsh, Douglas S.; Pichyangkul, Sathit] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand.
[Jongkaewwattana, Anan; Kramyu, Jarin] Natl Ctr Genet Engn & Biotechnol, Virol & Cell Technol Lab, Bangkok, Thailand.
[Thitithayanont, Arunee; Wiboon-ut, Suwimon] Mahidol Univ, Fac Sci, Bangkok 10400, Thailand.
[Garcia, Jean Michel; Peiris, Malik] Univ Hong Kong Pasteur Res Ctr, Hong Kong Special Adm Reg, Hong Kong, Hong Kong, Peoples R China.
[Thomas, Stephen; Jarman, Richard G.; Mongkolsirichaikul, Duangrat] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
[Mason, Carl; Khemnu, Nuanpan] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand.
RP Bethell, D (reprint author), Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand.
EM delia.bethell@afrims.org
RI Garcia, Jean-Michel/J-7166-2013
OI Garcia, Jean-Michel/0000-0002-6005-9982
FU MedImmune
FX This study was funded by a MedImmune Investigator-Initiated Research
Program grant from MedImmune. The funders had no role in study design,
data collection and analysis, decision to publish, or preparation of the
manuscript.
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U1 0
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 26
PY 2013
VL 8
IS 3
AR e59674
DI 10.1371/journal.pone.0059674
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 123VE
UT WOS:000317418500072
PM 23555741
ER
PT J
AU Weber, NS
Fisher, JA
Cowan, DN
Postolache, TT
Larsen, RA
Niebuhr, DW
AF Weber, Natalya S.
Fisher, Jared A.
Cowan, David N.
Postolache, Teodor T.
Larsen, Rakel A.
Niebuhr, David W.
TI Descriptive Epidemiology and Underlying Psychiatric Disorders among
Hospitalizations with Self-Directed Violence
SO PLOS ONE
LA English
DT Article
ID ATTEMPTED-SUICIDE; UNITED-STATES; HARM; LETHALITY; INJURY; ADULTS;
INTENT; RATES; RISK
AB Background: Suicide claims over one million lives worldwide each year. In the United States, 1 per 10,000 persons dies from suicide every year, and these rates have remained relatively constant over the last 20 years. There are nearly 25 suicide attempts for each suicide, and previous self-directed violence is a strong predictor of death from suicide. While many studies have focused on suicides, the epidemiology of non-fatal self-directed violence is not well-defined.
Objective: We used a nationally representative survey to examine demographics and underlying psychiatric disorders in United States (US) hospitalizations with non-fatal self-directed violence (SDV).
Method: International Classification of Disease, 9th Revision (ICD-9) discharge diagnosis data from the National Hospital Discharge Survey (NHDS) were examined from 1997 to 2006 using frequency measures and adjusted logistic regression.
Results: The rate of discharges with SDV remained relatively stable over the study time period with 4.5 to 5.7 hospitalizations per 10,000 persons per year. Excess SDV was documented for females, adolescents, whites, and those from the Midwest or West. While females had a higher likelihood of self-poisoning, both genders had comparable proportions of hospitalizations with SDV resulting in injury. Over 86% of the records listing SDV also included psychiatric disorders, with the most frequent being affective (57.8%) and substance abuse (37.1%) disorders. The association between psychiatric disorders and self-injury was strongest for personality disorders for both males (OR = 2.1; 95% CI = 1.3-3.4) and females (OR = 3.8; 95% CI = 2.7-5.3).
Conclusion: The NHDS provides new insights into the demographics and psychiatric morbidity of those hospitalized with SDV. Classification of SDV as self-injury or self-poisoning provides an additional parameter useful to epidemiologic studies.
C1 [Weber, Natalya S.; Fisher, Jared A.; Cowan, David N.; Larsen, Rakel A.; Niebuhr, David W.] Walter Reed Army Inst Res, Prevent Med Program, Silver Spring, MD USA.
[Fisher, Jared A.; Cowan, David N.; Larsen, Rakel A.] Allied Technol Grp Inc, Rockville, MD USA.
[Postolache, Teodor T.] Univ Maryland, Sch Med, Dept Psychiat, Mood & Anxiety Program, Baltimore, MD 21201 USA.
[Niebuhr, David W.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA.
RP Weber, NS (reprint author), Walter Reed Army Inst Res, Prevent Med Program, Silver Spring, MD USA.
EM Natalya.Weber@us.army.mil
FU Stanley Medical Research Institute, Bethesda, MD, (CRADA)
[DAMD17-04-0041]; Department of the Army; Walter Reed Army Institute of
Research (WRAIR)
FX The effort is funded by the Stanley Medical Research Institute,
Bethesda, MD, (CRADA# DAMD17-04-0041,
http://www.stanleyresearch.org/dnn/ResearchGrants/Overview/tabid/156/Def
ault.aspx) and the Department of the Army. The funders had no role in
study design, data collection and analysis, decision to publish, or
preparation of the manuscript.; ATG has had a service support contract
with the Walter Reed Army Institute of Research (WRAIR) for over 15
years. ATG personnel include epidemiologists and statisticians who
support and collaborate with the WRAIR researchers. ATG staff are all at
the master's or doctoral level of training, and they assist in the
design, analysis, interpretation and presentation of studies, and in
writing and publishing of manuscripts for peer-reviewed journals. There
is no financial or other conflict of interest between ATG staff and any
of the research with which they participate. ATG and its staff members
are contractors with no vested interests in the results, conclusions,
and recommendations resulting from any research and have no interests
related to employment, consultancy, patents, products in development or
marketed products, or any other aspect of this research. Even though
Natalya S. Weber, M. D., M. P. H., is a PLOS One Editorial board member,
this does not alter the authors' adherence to all the PLOS ONE policies
on sharing data and materials.
NR 41
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PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 26
PY 2013
VL 8
IS 3
AR e59818
DI 10.1371/journal.pone.0059818
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 123VE
UT WOS:000317418500094
PM 23555791
ER
PT J
AU Naik, RS
Pattabiraman, N
Patel, KA
Doctor, BP
Saxena, A
AF Naik, Ramachandra S.
Pattabiraman, Nagarajan
Patel, Kunjan A.
Doctor, Bhupendra P.
Saxena, Ashima
TI Amino acid residues at the N- and C-termini are essential for the
folding of active human butyrylcholinesterase polypeptide
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article; Proceedings Paper
CT International Meeting on Cholinesterases
CY JUN 04-09, 2012
CL Kazan, RUSSIA
DE Human butyrylcholinesterase; Nerve agent; Organophosphorus compounds;
Polypeptide; Bioscavenger
ID ACETYLCHOLINESTERASE; CHOLINESTERASES; PROTECTION; INHIBITORS; TOXICITY;
PROTEINS; SOMAN
AB Human serum butyrylcholinesterase (HuBChE) is currently the most suitable bioscavenger for the prophylaxis of highly toxic organophosphate (OP) nerve agents. A dose of 200 mg of HuBChE is envisioned as a prophylactic treatment that can protect humans from an exposure of up to 2 x LD50 of soman. The limited availability and administration of multiple doses of this stoichiometric bioscavenger make this pretreatment difficult. Thus, the goal of this study was to produce a smaller enzymatically active HuBChE polypeptide (HBP) that could bind to nerve agents with high affinity thereby reducing the dose of enzyme. Studies have indicated that the three-dimensional structure and the domains of HuBChE (acyl pocket, lip of the active center gorge, and the anionic substrate-binding domain) that are critical for the binding of substrate are also essential for the selectivity and binding of inhibitors including OPs. Therefore, we designed three HBPs by deleting some N- and C-terminal residues of HuBChE by maintaining the folds of the active site core that includes the three active site residues (S198, E325, and H438). HBP-4 that lacks 45 residues from C-terminus but known to have BChE activity was used as a control. The cDNAs for the HBPs containing signal sequences were synthesized, cloned into different mammalian expression vectors, and recombinant polypeptides were transiently expressed in different cell lines. No BChE activity was detected in the culture media of cells transfected with any of the newly designed HBPs, and the inactive polypeptides remained inside the cells. Only enzymatically active HBP-4 was secreted into the culture medium. These results suggest that residues at the N- and C-termini are required for the folding and/or maintenance of HBP into an active stable, conformation. Published by Elsevier Ireland Ltd.
C1 [Naik, Ramachandra S.; Pattabiraman, Nagarajan; Patel, Kunjan A.; Saxena, Ashima] Walter Reed Army Inst Res, Bacterial Dis Branch, Silver Spring, MD 20910 USA.
[Doctor, Bhupendra P.] Walter Reed Army Inst Res, Closed Head Injury Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA.
RP Saxena, A (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM ashima.saxena@us.army.mil
FU Defense Threat Reduction Agency
FX This work was supported by the Defense Threat Reduction Agency which
played no role in the design, conduct, interpretation, or report of the
study. The opinions or assertions contained herein are the private views
of the authors, and are not to be construed as official, or as
reflecting true views of the Department of the Army or the Department of
Defense.
NR 18
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PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD MAR 25
PY 2013
VL 203
IS 1
SI SI
BP 24
EP 29
DI 10.1016/j.cbi.2012.09.018
PG 6
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA 134HU
UT WOS:000318201800006
PM 23044488
ER
PT J
AU Maxwell, DM
Brecht, KM
Sweeney, RE
AF Maxwell, Donald M.
Brecht, Karen M.
Sweeney, Richard E.
TI A common mechanism for resistance to oxime reactivation of
acetylcholinesterase inhibited by organophosphorus compounds
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article; Proceedings Paper
CT International Meeting on Cholinesterases
CY JUN 04-09, 2012
CL Kazan, RUSSIA
DE Acetylcholinesterase; Oxime; Reactivation; Organophosphorus;
Structure-activity
ID CRYSTAL-STRUCTURES; KINETIC-ANALYSIS; CHOLINESTERASES
AB Administration of oxime therapy is currently the standard approach used to reverse the acute toxicity of organophosphorus (OP) compounds, which is usually attributed to OP inhibition of acetylcholinesterase (AChE). Rate constants for reactivation of OP-inhibited AChE by even the best oximes, such as HI-6 and obidoxime, can vary >100-fold between OP-AChE conjugates that are easily reactivated and those that are difficult to reactivate. To gain a better understanding of this oxime specificity problem for future design of improved reactivators, we conducted a QSAR analysis for oxime reactivation of AChE inhibited by OP agents and their analogues. Our objective was to identify common mechanism(s) among OP-AChE conjugates of phosphates, phosphonates and phosphoramidates that result in resistance to oxime reactivation. Our evaluation of oxime reactivation of AChE inhibited by a satin analogue, O-methyl isopropylphosphonofluoridate, or a cyclosarin analogue, O-methyl cyclohexylphosphonofluoridate, indicated that AChE inhibited by these analogues was at least 70-fold more difficult to reactivate than AChE inhibited by sarin or cyclosarin. In addition, AChE inhibited by an analogue of tabun (i.e., O-ethyl isopropylphosphonofluoridate) was nearly as resistant to reactivation as tabun-inhibited AChE. QSAR analysis of oxime reactivation of AChE inhibited by these OP compounds and others suggested that the presence of both a large substituent (i.e., the size of dimethylamine) and an alkoxy substituent in the structure of OP compounds is the common feature that results in resistance to oxime reactivation of OP-AChE conjugates whether the OP is a phosphate, phosphonate or phosphoramidate. Published by Elsevier Ireland Ltd.
C1 [Maxwell, Donald M.; Brecht, Karen M.; Sweeney, Richard E.] USA, Med Res Inst Chem Def, Pharmacol Branch, Aberdeen Proving Ground, MD 21010 USA.
RP Maxwell, DM (reprint author), USA, Med Res Inst Chem Def, Pharmacol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM donald.maxwell@us.army.mil
FU Defense Threat Reduction Agency - Joint Science and Technology Office,
Medical S T Division
FX This research was supported by the Defense Threat Reduction Agency -
Joint Science and Technology Office, Medical S & T Division. The views
expressed in this paper are those of the authors and do not reflect the
official policy of the Department of Army, Department of Defense or the
US Government.
NR 20
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U1 1
U2 41
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD MAR 25
PY 2013
VL 203
IS 1
SI SI
BP 72
EP 76
DI 10.1016/j.cbi.2012.08.024
PG 5
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA 134HU
UT WOS:000318201800016
PM 22982773
ER
PT J
AU Wang, Y
Wei, YL
Oguntayo, S
Doctor, BP
Nambiar, MP
AF Wang, Ying
Wei, Yanling
Oguntayo, Samuel
Doctor, Bhupendra P.
Nambiar, Madhusoodana P.
TI A combination of [ plus ] and [-]-Huperzine A improves protection
against soman toxicity compared to [ plus ]-Huperzine A in guinea pigs
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article; Proceedings Paper
CT International Meeting on Cholinesterases
CY JUN 04-09, 2012
CL Kazan, RUSSIA
DE Neuroprotection; Prophylaxis; Nerve agents; [ plus ]-Huperzine A;
[-]-Huperzine A; Seizure; Acetylcholinesterase
ID BETA-AMYLOID PEPTIDE; NERVE AGENT TOXICITY; RAT PC12 CELLS; HUPERZINE-A;
INDUCED SEIZURES; HUMAN BUTYRYLCHOLINESTERASE; OXIDATIVE STRESS;
GROWTH-FACTOR; IN-VITRO; ACETYLCHOLINESTERASE
AB The neuropathologic mechanisms after exposure to lethal doses of nerve agent are complex and involve multiple biochemical pathways. Effective treatment requires drugs that can simultaneously protect by reversible binding to the acetylcholinesterase (AChE) and blocking cascades of seizure related brain damage, inflammation, neuronal degeneration as well as promoting induction of neuroregeneration. [-]-Huperzine A ([-]-Hup A), is a naturally occurring potent reversible AChE inhibitor that penetrates the blood brain barrier. It also has several neuroprotective effects including modification of beta-amyloid peptide, reduction of oxidative stress, anti-inflammatory, anti-apoptotic and induction and regulation of nerve growth factor. Toxicities at higher doses restrict the neuroporotective ability of [-]-Hup A for treatment. The synthetic stereoisomer, [+]-Hup A, is less toxic due to poor AChE inhibition and is suitable for both pre-/post-exposure treatments of nerve agent toxicity. [+]-Hup A block the N-methyl-D-aspartate (NMDA)-induced seizure in rats, reduce excitatory amino acid induced neurotoxicity and also prevent soman induced toxicity with minimum performance decrement. Unique combinations of two stereoisomers of Hup A may provide an excellent pre/post-treatment drug for the nerve agent induced seizure/status epilepticus. We investigated a combination of [+]-Hup A with a small dose of [+]-Hup A ([+] and [-]-Hup A) against soman toxicity. Our data showed that pretreatment with a combination [+] and [-]-Hup A significantly increased the survival rate and reduced behavioral abnormalities after exposure to 1.2 x LD50 soman compared to [+]-Hup A in guinea pigs. In addition, [+] and [-]-Hup A pretreatment inhibited the development of high power of EEG better than [+]-Hup A pretreatment alone. These data suggest that a combination of [+] and [-]-Hup A offers better protection than [+]-Hup A and serves as a potent medical countermeasure against lethal dose nerve agent toxicity in guinea pigs. (C) 2012 Published by Elsevier Ireland Ltd.
C1 [Wang, Ying; Wei, Yanling; Oguntayo, Samuel; Doctor, Bhupendra P.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Blast Induced Neurotrauma Branch, Silver Spring, MD 20910 USA.
RP Nambiar, MP (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Blast Induced Neurotrauma Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM ying.wangv@us.army.mil; Madhusoodana.nambiar@us.army.mil
FU Defense Threat Reduction Agency (DTRA) [1.E0003_08_WR_C]
FX This work was supported by funding from Defense Threat Reduction Agency
(DTRA) Grant #1.E0003_08_WR_C. The technical assistance from the
Collaborative Research Facility, USAMRICD is greatly acknowledged.
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PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD MAR 25
PY 2013
VL 203
IS 1
SI SI
BP 120
EP 124
DI 10.1016/j.cbi.2012.10.016
PG 5
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA 134HU
UT WOS:000318201800025
PM 23123250
ER
PT J
AU Bhonsle, JB
Causey, R
Oyler, BL
Bartolucci, C
Lamba, D
Pesaresi, A
Bhamare, NK
Soojhawon, I
Garcia, GE
AF Bhonsle, Jayendra B.
Causey, Robert
Oyler, Benjamin L.
Bartolucci, Cecilia
Lamba, Doriano
Pesaresi, Alessandro
Bhamare, Nanaji K.
Soojhawon, Iswarduth
Garcia, Gregory E.
TI Evaluation and computational characterization of the facilitated
transport of Glc carbon C-1 oxime reactivators across a blood brain
barrier model
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article; Proceedings Paper
CT International Meeting on Cholinesterases
CY JUN 04-09, 2012
CL Kazan, RUSSIA
DE Facilitated transport; Sugar-oximes; SOx; Blood brain barrier;
Reactivation; Acetylcholinesterase
ID GLUT1 GLUCOSE-TRANSPORTER; NERVE AGENTS; ACETYLCHOLINESTERASE;
ANTIDOTES; DERIVATIVES; MECHANISM; CONTAINS; EFFICACY; DOCKING; HI-6
AB We are evaluating a facilitative transport strategy to move oximes across the blood brain barrier (BBB) to reactivate inhibited brain acetylcholinesterase (AChE). We selected glucose (Glc) transporters (GLUT) for this purpose as these transporters are highly represented in the BBB. Glc conjugates have successfully moved drugs across the BBB and previous work has shown that Glc-oximes (sugar-oximes, SOxs) can reduce the organophosphonate induced hypothermia response. We previously evaluated the reactivation potential of Glc carbon C-1 SOxs. Here we report the reactivation parameters for VX- and GB-inhibited human (Hu) AChE of the best SOx (13c) and our findings that the kinetics are similar to those of the parent oxime. Although crystals of Torpedo californica AChE were produced, neither soaked or co-crystallized experiments were successful at concentrations below 20 mM 13c, and higher concentrations cracked the crystals. 13c was non-toxic to neuroblastoma and kidney cell lines at 12-18 mM, allowing high concentrations to be used in a BBB kidney cell model. The transfer of 13c from the donor side was asymmetric with the greatest loss of 13c from the apical- or luminal-treated side. There was no apparent transfer from the basolateral side. The 13c P-app results indicate a 'low' transport efficiency: however, mass accounting revealed only a 20% recovery from the apical dose in which high concentrations were found in the cell lysate fraction. Molecular modeling of 13c through the GLUT-1 channel demonstrated that transport of 13c was more restricted than Glc. Selected sites were compared and the 13c binding energies were greater than two times those of Glc. Published by Elsevier Ireland Ltd.
C1 [Bhonsle, Jayendra B.] Astha Drug Discovery & Res, Rockville, MD 20852 USA.
[Causey, Robert; Bhamare, Nanaji K.; Garcia, Gregory E.] USA, Med Res Inst Chem Def, Div Res, Aberdeen Proving Ground, MD 21010 USA.
[Oyler, Benjamin L.] USA, Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA.
[Bartolucci, Cecilia] CNR, Ist Cristallografia, I-00015 Monterotondo, Roma, Italy.
[Lamba, Doriano; Pesaresi, Alessandro] CNR, Ist Cristallografia, I-34149 Trieste, Italy.
[Soojhawon, Iswarduth] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA.
RP Garcia, GE (reprint author), USA, Med Res Inst Chem Def, Div Res, 3100 Ricketts,Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM Gregory.E.Garcia@us.army.mil
RI Lamba, Doriano/B-2961-2011;
OI Lamba, Doriano/0000-0001-6859-7868; Oyler, Benjamin/0000-0003-3436-9175
FU Defense Threat Reduction Agency [1.E005.08.WR]
FX Excellent technical assistance was provided by Ms. Janine Ladzinski for
cell culture toxicological testing. This work was supported by Defense
Threat Reduction Agency (Grant number 1.E005.08.WR). The views expressed
herein are those of the author(s) and do not reflect the official policy
of the Department of Army, Department of Defense, or the U.S.
Government.
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PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD MAR 25
PY 2013
VL 203
IS 1
SI SI
BP 129
EP 134
DI 10.1016/j.cbi.2012.09.012
PG 6
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA 134HU
UT WOS:000318201800027
PM 23073172
ER
PT J
AU Sun, W
Luo, C
Tipparaju, P
Doctor, BP
Saxena, A
AF Sun, Wei
Luo, Chunyuan
Tipparaju, Prasanthi
Doctor, Bhupendra P.
Saxena, Ashima
TI Effect of polyethylene glycol conjugation on the circulatory stability
of plasma-derived human butyrylcholinesterase in mice
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article; Proceedings Paper
CT International Meeting on Cholinesterases
CY JUN 04-09, 2012
CL Kazan, RUSSIA
DE Butyrylcholinesterase; Bioscavenger; Polyethylene glycol;
Organophosphorus compounds; Circulatory stability; Mice
ID HUMAN SERUM BUTYRYLCHOLINESTERASE; RECOMBINANT HUMAN
BUTYRYLCHOLINESTERASE; NERVE AGENT TOXICITY; IN-VIVO STABILITY;
HALF-LIFE; COVALENT ATTACHMENT; COCAINE TOXICITY; SARIN VAPOR;
GUINEA-PIGS; CHOLINESTERASE
AB Exogenously administered human serum butyrylcholinesterase (Hu BChE) was demonstrated to function as a bioscavenger of highly toxic organophosphorus (OP) compounds in several animal species. Since the enzyme is isolated from human serum, it is currently the most suitable pretreatment for human use. A dose of 200-300 mg/70 kg human adult is projected to provide protection from 2 x LD50 of soman. Due to the limited supply of Hu BChE, strategies aimed at reducing the dose of enzyme are being explored. In this study, we investigated the effect of modification with polyethylene glycol (PEG) on the in vivo stability of Hu BChE. Mice were given two injections of either Hu BChE or Hu BChE modified with PEG-5K or PEG-20K, six weeks apart. Pharmacokinetic parameters, such as mean residence time (MRT), maximal concentration (C-max), elimination half-life (T-1/2), and area under the plasma concentration time curve extrapolated to infinity (AUC), were determined. For the first injection, values for MRT, T-1/2, C-max, and AUC for PEG-5K-Hu BChE and PEG-20K-Hu BChE were similar to those for Hu BChE. These values for the second injection of Hu BChE as well as PEG-Hu BChEs were lower as compared to those for the first injections, likely due to antibody-mediated clearance. Published by Elsevier Ireland Ltd.
C1 [Sun, Wei; Luo, Chunyuan; Tipparaju, Prasanthi; Doctor, Bhupendra P.; Saxena, Ashima] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA.
RP Saxena, A (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM Ashima.saxena@us.army.mil
FU United States Army Medical Research and Materiel Command
FX The authors wish to thank Dr. Yvonne Rosenberg and Dr. Xiaoming Jiang
(Plantvax Inc., Rockville, MD) for help with the calculations of
pharmacokinetic parameters. This work was supported by the United States
Army Medical Research and Materiel Command.
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PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD MAR 25
PY 2013
VL 203
IS 1
SI SI
BP 172
EP 176
DI 10.1016/j.cbi.2012.11.021
PG 5
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA 134HU
UT WOS:000318201800035
PM 23220586
ER
PT J
AU Hodgins, SM
Kasten, SA
Harrison, J
Otto, TC
Oliver, ZP
Rezk, P
Reeves, TE
Chilukuri, N
Cerasoli, DM
AF Hodgins, Sean M.
Kasten, Shane A.
Harrison, Joshua
Otto, Tamara C.
Oliver, Zeke P.
Rezk, Peter
Reeves, Tony E.
Chilukuri, Nageswararao
Cerasoli, Douglas M.
TI Assessing protection against OP pesticides and nerve agents provided by
wild-type HuPON1 purified from Trichoplusia ni larvae or induced via
adenoviral infection
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article; Proceedings Paper
CT International Meeting on Cholinesterases
CY JUN 04-09, 2012
CL Kazan, RUSSIA
DE Organophosphorus; Nerve agent; Paraoxonase 1; Catalytic bioscavenger; In
vivo efficacy
ID HUMAN SERUM PARAOXONASE; HYDROLYSIS; POLYMORPHISM; HYDROLASES; DIAZOXON;
ESTERS; SOMAN; PON1
AB Human paraoxonase-1 (HuPON1) has been proposed as a catalytic bioscavenger of organophosphorus (OP) pesticides and nerve agents. We assessed the potential of this enzyme to protect against OP poisoning using two different paradigms. First, recombinant HuPON1 purified from cabbage loopers (iPON1; Trichoplusia ni) was administered to guinea pigs, followed by exposure to at least 2 times the median lethal dose (LD50) of the OP nerve agents tabun (GA), satin (GB), soman (GD), and cyclosarin (GF), or chlorpyrifos oxon, the toxic metabolite of the OP pesticide chlorpyrifos. In the second model, mice were infected with an adenovirus that induced expression of HuPON1 and then exposed to sequential doses of GD. VX, or (as reported previously) diazoxon, the toxic metabolite of the OP pesticide diazinon. In both animal models, the exogenously added HuPON1 protected animals against otherwise lethal doses of the OP pesticides but not against the nerve agents. Together, the results support prior modeling and in vitro activity data which suggest that wild-type HuPON1 does not have sufficient catalytic activity to provide in vivo protection against nerve agents. Published by Elsevier Ireland Ltd.
C1 [Hodgins, Sean M.; Kasten, Shane A.; Harrison, Joshua; Otto, Tamara C.; Oliver, Zeke P.; Rezk, Peter; Reeves, Tony E.; Chilukuri, Nageswararao; Cerasoli, Douglas M.] USA, Med Res Inst Chem Def, Div Res, Physiol & Immunol Branch, Aberdeen Proving Ground, MD 21010 USA.
RP Cerasoli, DM (reprint author), USA, Med Res Inst Chem Def, Div Res, Physiol & Immunol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM douglas.cerasoli@us.army.mil
FU Defense Threat Reduction Agency-Joint Science and Technology Office,
Medical ST Division; US Army Medical Research Institute of Chemical
Defense
FX This work was supported by the Defense Threat Reduction Agency-Joint
Science and Technology Office, Medical S&T Division. S.M.H., S.A.K,
J.L.H., T.C.O., Z.P.O., P.E.K., and T.E.R. were supported in part by an
appointment to the Internship/Research Participation Program for the US
Army Medical Research Institute of Chemical Defense, administered by the
Oak Ridge Institute for Science and Education through an agreement
between the US Department of Energy and the USAMRICD.
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PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD MAR 25
PY 2013
VL 203
IS 1
SI SI
BP 177
EP 180
DI 10.1016/j.cbi.2012.10.015
PG 4
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA 134HU
UT WOS:000318201800036
PM 23123254
ER
PT J
AU Kirby, SD
Norris, JR
Smith, JR
Bahnson, BJ
Cerasoli, DM
AF Kirby, Stephen D.
Norris, Joseph R.
Smith, J. Richard
Bahnson, Brian J.
Cerasoli, Douglas M.
TI Human paraoxonase double mutants hydrolyze V and G class
organophosphorus nerve agents
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article; Proceedings Paper
CT International Meeting on Cholinesterases
CY JUN 04-09, 2012
CL Kazan, RUSSIA
DE Human; Paraoxonase; PON1; Organophosphorus; OP; Nerve agent
ID HUMAN SERUM PARAOXONASE; RHESUS-MONKEYS; BUTYRYLCHOLINESTERASE;
STEREOISOMERS
AB Variants of human paraoxonase 1 (PON1) are being developed as catalytic bioscavengers for the organophosphorus chemical warfare agents (OP). It is preferable that the new PON1 variants have broad spectrum hydrolase activities to hydrolyze both G- and V-class OPs. H115W PON1 has shown improvements over wild type PON1 in its capacity to hydrolyze some OP compounds. We improved upon these activities either by substituting a tryptophan (F347W) near the putative active site residues for enhanced substrate binding or by reducing a bulky group (Y71A) at the periphery of the putative enzyme active site. When compared to H115W alone, we found that H115W/Y71A and H115W/F347W maintained VX catalytic efficiency but showed mixed results for the capacity to hydrolyze paraoxon. Testing our double mutants against racemic sarin, we observed reduced values of Km for H115W/F347W that modestly improved catalytic efficiency over wild type and H115W. Contrary to previous reports, we show that H115W can hydrolyze soman, and the double mutant H115W/Y71A is nearly 4-fold more efficient than H115W for paraoxon hydrolysis. We also observed modest stereoselectivity for hydrolysis of the P(-) stereoisomer of tabun by H115W/F347W. These data demonstrate enhancements made in PON1 for the purpose of developing an improved catalytic bioscavenger to protect cholinesterase against chemical warfare agents. Published by Elsevier Ireland Ltd.
C1 [Kirby, Stephen D.; Norris, Joseph R.; Smith, J. Richard; Cerasoli, Douglas M.] USA, Med Res Inst Chem Def, Div Res, Physiol & Immunol Branch, Aberdeen Proving Ground, MD 21010 USA.
[Kirby, Stephen D.; Bahnson, Brian J.] Univ Delaware, Dept Chem & Biochem, Newark, DE 19716 USA.
RP Kirby, SD (reprint author), USA, Med Res Inst Chem Def, Div Res, Physiol & Immunol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM stephen.drew.kirby@us.army.mil
FU Defense Threat Reduction Agency - Joint Science and Technology Office,
Medical ST Division [1.D0019_08_RC_C]
FX The views expressed in this article are those of the author(s) and do
not reflect the official policy of the Department of Army, Department of
Defense, or the US Government. This research was supported by the
Defense Threat Reduction Agency - Joint Science and Technology Office,
Medical S&T Division, under project 1.D0019_08_RC_C.
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PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD MAR 25
PY 2013
VL 203
IS 1
SI SI
BP 181
EP 185
DI 10.1016/j.cbi.2012.10.023
PG 5
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA 134HU
UT WOS:000318201800037
PM 23159884
ER
PT J
AU Otto, TC
Scott, JR
Kauffman, MA
Hodgins, SM
diTargiani, RC
Hughes, JH
Sarricks, EP
Saturday, GA
Hamilton, TA
Cerasoli, DM
AF Otto, Tamara C.
Scott, Jennifer R.
Kauffman, Monika A.
Hodgins, Sean M.
diTargiani, Robert C.
Hughes, James H.
Sarricks, Erin P.
Saturday, Greg A.
Hamilton, Tracey A.
Cerasoli, Douglas M.
TI Identification and characterization of novel catalytic bioscavengers of
organophosphorus nerve agents
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article; Proceedings Paper
CT International Meeting on Cholinesterases
CY JUN 04-09, 2012
CL Kazan, RUSSIA
DE Organophosphorus; Nerve agent; Catalytic bioscavenger; Micromonospora
aurantiaca
ID TOKYO SUBWAY; TOXICITY; SOMAN
AB In an effort to discover novel catalytic bioscavengers of organophosphorus (OP) nerve agents, cell lysates from a diverse set of bacterial strains were screened for their capacity to hydrolyze the OP nerve agents VX. VR., and soman (GD). The library of bacterial strains was identified using both random and rational approaches. Specifically, two representative strains from eight categories of extremophiles were chosen at random. For the rational approach, the protein sequence of organophosphorus hydrolase (OPH) from Brevundimonas diminuta was searched against a non-redundant protein database using the Basic Local Alignment Search Tool to find regions of local similarity between sequences. Over 15 protein sequences with significant sequence similarity to OPH were identified from a variety of bacterial strains. Some of these matches were based on predicted protein structures derived from bacterial genome sequences rather than from bona fide proteins isolated from bacteria. Of the 25 strains selected for nerve agent testing, three bacterial strains had measurable levels of OP hydrolase activity. These strains are Ammoniphilus oxalaticus, Haloarcula sp., and Micromonospora aurantiaca. Lysates from A. oxalaticus had detectable hydrolysis of VR; Haloarcula sp. had appreciable hydrolysis of VX and VR, whereas lysates from M. aurantiaca had detectable hydrolysis of VR and GD. Published by Elsevier Ireland Ltd.
C1 [Otto, Tamara C.] USA, Med Res Inst Chem Def, Neurobehav Toxicol Branch, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA.
[Scott, Jennifer R.; Kauffman, Monika A.; Hodgins, Sean M.; diTargiani, Robert C.; Cerasoli, Douglas M.] USA, Med Res Inst Chem Def, Physiol & Immunol Branch, Div Res, Aberdeen Proving Ground, MD 21010 USA.
[Hughes, James H.; Sarricks, Erin P.; Saturday, Greg A.; Hamilton, Tracey A.] USA, Med Res Inst Chem Def, Comparat Pathol Branch, Res Support Div, Aberdeen Proving Ground, MD 21010 USA.
RP Otto, TC (reprint author), USA, Med Res Inst Chem Def, Neurobehav Toxicol Branch, Analyt Toxicol Div, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM tamara.c.otto@us.army.mil
FU Defense Threat Reduction Agency-Joint Science and Technology Office,
Medical ST Division
FX We gratefully acknowledge Drs. Ann Hirsch and Nancy Fujishige (UCLA) for
helpful comments regarding the growth of M. aurantiaca as well as
sharing unpublished results. This work was supported by the Defense
Threat Reduction Agency-Joint Science and Technology Office, Medical S&T
Division. J.R.S., M.A.K., S.M.H., and R.C.D. were supported in part by
an appointment to the Internship/Research Participation Program for the
U.S. Army Medical Re search Institute of Chemical Defense, administered
by the Oak Ridge Institute for Science and Education and the USAMRICD.
The views expressed in this manuscript are those of the authors and do
not reflect the official policy of the Department of Army, Department of
Defense, or the U.S. Government.
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PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD MAR 25
PY 2013
VL 203
IS 1
SI SI
BP 186
EP 190
DI 10.1016/j.cbi.2012.09.009
PG 5
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA 134HU
UT WOS:000318201800038
PM 23041042
ER
PT J
AU Aleti, V
Reddy, GB
Parikh, K
Arun, P
Chilukuri, N
AF Aleti, Vineela
Reddy, Gireesh B.
Parikh, Kalpana
Arun, Peethambaran
Chilukuri, Nageswararao
TI Persistent and high-level expression of human liver prolidase in vivo in
mice using adenovirus
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article; Proceedings Paper
CT International Meeting on Cholinesterases
CY JUN 04-09, 2012
CL Kazan, RUSSIA
DE Human liver prolidase; Adenovirus; Gene delivery; Chemical warfare nerve
agents; Catalytic bioscavenger
ID NERVE AGENT TOXICITY; GENE-TRANSFER; PROTECTION; PURIFICATION
AB Human liver prolidase, a metal-dependent dipeptidase, is being tested as a potential catalytic bioscavenger against organophosphorus (OP) chemical warfare nerve agents. The purpose of this study was to determine whether persistent and high-levels of biologically active and intact recombinant human (rHu) prolidase could be introduced in vivo in mice using adenovirus (Ad). Here, we report that a single intravenous injection of Ad containing the prolidase gene with a 6x histidine-tag (Ad-prolidase) introduced high-levels of rHu prolidase in the circulation of mice which peaked on days 5-7 at 159 +/- 129 U/mL This level of prolidase is 120 times greater than that of the enzyme level in mice injected with Ad-null virus. To determine if all of Ad-prolidase-produced rHu prolidase was exported into the circulation, enzyme activity was measured in a variety of tissues. Liver contained the highest levels of rHu prolidase on day 7 (5647 454 U/g) compared to blood or any other tissue. Recombinant Hu prolidase hydrolyzed DFP, a simulant of OP nerve agents, in vitro. In vivo, prolidase overexpression extended the survival of 4 out of 6 mice by 4-8 h against exposure to two 1 x LD50 doses of DFP. In contrast, overexpression of mouse butyrylcholinesterase (BChE), a proven stoichiometric bioscavenger of OP compounds, protected 5 out of 6 mice from DFP lethality and surviving mice showed no symptoms of DFP toxicity. In conclusion, the results suggest that gene delivery using Ad is capable of introducing persistent and high levels of human liver prolidase in vivo. The gene-delivered prolidase hydrolyzed DFP in vitro but provided only modest protection in vivo in mice, delaying the death of the animals by only 4-8 h. Published by Elsevier Ireland Ltd.
C1 [Aleti, Vineela; Reddy, Gireesh B.; Parikh, Kalpana; Arun, Peethambaran; Chilukuri, Nageswararao] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA.
RP Chilukuri, N (reprint author), USA, Med Res Inst Chem Def, Div Res, Physiol & Immunol Branch,USAMRICD, 3100 Rickets Point Rd, Edgewood, MD 21010 USA.
EM Nageswararao.chilukuri@us.army.mil
OI Reddy, Gireesh/0000-0001-6112-2309
FU Defense Threat Reduction Agency - Joint Science and Technology Office,
Medical ST Division [1. D0003_09_RC_C]
FX This research was supported by the Defense Threat Reduction Agency -
Joint Science and Technology Office, Medical S&T Division (Project # 1.
D0003_09_RC_C). We thank Drs. Douglas M. Cerasoli, Carolyn P. Chambers,
and Brian M. Keyser and CPT Carl Smith for critical evaluation of the
manuscript. We also thank the staff at Washington Biotechnology Inc.,
Columbia, MD for their technical help with the animal experiments.
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PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD MAR 25
PY 2013
VL 203
IS 1
SI SI
BP 191
EP 195
DI 10.1016/j.cbi.2012.08.021
PG 5
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA 134HU
UT WOS:000318201800039
PM 22982776
ER
PT J
AU Valiyaveettil, M
Alamneh, YA
Miller, SA
Hammamieh, R
Arun, P
Wang, Y
Wei, YL
Oguntayo, S
Long, JB
Nambiar, MP
AF Valiyaveettil, Manojkumar
Alamneh, Yonas A.
Miller, Stacey-Ann
Hammamieh, Rasha
Arun, Peethambaran
Wang, Ying
Wei, Yanling
Oguntayo, Samuel
Long, Joseph B.
Nambiar, Madhusoodana P.
TI Modulation of cholinergic pathways and inflammatory mediators in
blast-induced traumatic brain injury
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article; Proceedings Paper
CT International Meeting on Cholinesterases
CY JUN 04-09, 2012
CL Kazan, RUSSIA
DE Repeated blast exposure; Cholinergic pathway; Inflammation;
Acetylcholinisterase; Micro RNA; Traumatic brain injury
ID ANTIINFLAMMATORY PATHWAY; ACETYLCHOLINESTERASE ACTIVITY; LUNG TRAUMA;
STRESS; MODEL; BLOOD; MICRORNAS; EXPOSURE; MOUSE; RATS
AB Cholinergic activity has been recognized as a major regulatory component of stress responses after traumatic brain injury (TB!). Centrally acting acetylcholinesterase (AChE) inhibitors are also being considered as potential therapeutic candidates against TBI mediated cognitive impairments. We have evaluated the expression of molecules involved in cholinergic and inflammatory pathways in various regions of brain after repeated blast exposures in mice. Isoflurane anesthetized C57BL/6J mice were restrained and placed in a prone position transverse to the direction of the shockwaves and exposed to three 20.6 psi blast overpressures with 1-30 min intervals. Brains were collected at the 6 h time point after the last blast exposure and subjected to cDNA microarray and microRNA analysis. cDNA microarray analysis showed significant changes in the expression of cholinergic (muscarinic and nicotinic) and gammaaminobutyric acid and glutamate receptors in the midbrain region along with significant changes in multiple genes involved in inflammatory pathways in various regions of the brain. MicroRNA analysis of cerebellum revealed differential expression of miR-132 and 183, which are linked to cholinergic anti-inflammatory signaling, after blast exposure. Changes in the expression of myeloperoxidase in the cerebellum were confirmed by Western blotting. These results indicate that early pathologic progression of blast TBI involves dysregulation of cholinergic and inflammatory pathways related genes. Acute changes in molecules involved in the modulation of cholinergic and inflammatory pathways after blast TBI can cause long-term central and peripheral pathophysiological changes. (C) 2012 Published by Elsevier Ireland Ltd.
C1 [Valiyaveettil, Manojkumar; Alamneh, Yonas A.; Arun, Peethambaran; Wang, Ying; Wei, Yanling; Oguntayo, Samuel; Long, Joseph B.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA.
[Miller, Stacey-Ann; Hammamieh, Rasha] USA, Ctr Environm Hlth Res, Med Res & Mat Command, Ft Detrick, MD 21702 USA.
RP Valiyaveettil, M (reprint author), Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA.
EM m.valiyaveettil@amedd.army.mil; madhu-soodana.nambiar@amedd.army.mil
NR 31
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U1 0
U2 16
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD MAR 25
PY 2013
VL 203
IS 1
SI SI
BP 371
EP 375
DI 10.1016/j.cbi.2012.10.022
PG 5
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA 134HU
UT WOS:000318201800074
PM 23159883
ER
PT J
AU Filone, CM
Hodges, EN
Honeyman, B
Bushkin, GG
Boyd, K
Platt, A
Ni, F
Strom, K
Hensley, L
Snyder, JK
Connor, JH
AF Filone, Claire Marie
Hodges, Erin N.
Honeyman, Brian
Bushkin, G. Guy
Boyd, Karla
Platt, Andrew
Ni, Feng
Strom, Kyle
Hensley, Lisa
Snyder, John K.
Connor, John H.
TI Identification of a Broad-Spectrum Inhibitor of Viral RNA Synthesis:
Validation of a Prototype Virus-Based Approach
SO CHEMISTRY & BIOLOGY
LA English
DT Article
ID VESICULAR STOMATITIS-VIRUS; DIVERSITY-ORIENTED SYNTHESIS; MAJOR SURFACE
GLYCOPROTEIN; MONOCLONAL-ANTIBODIES; ANTIVIRAL DRUG; EBOLA-VIRUS;
REPLICATION; RIBAVIRIN; TRANSCRIPTION; MUTATIONS
AB There are no approved therapeutics for the most deadly nonsegmented negative-strand (NNS) RNA viruses, including Ebola (EBOV). To identify chemical scaffolds for the development of broad-spectrum antivirals, we undertook a prototype-based lead identification screen. Using the prototype NNS virus, vesicular stomatitis virus (VSV), multiple inhibitory compounds were identified. Three compounds were investigated for broad-spectrum activity and inhibited EBOV infection. The most potent, CMLDBU3402, was selected for further study. CMLDBU3402 did not show significant activity against segmented negative-strand RNA viruses, suggesting proscribed broad-spectrum activity. Mechanistic analysis indicated that CMLDBU3402 blocked VSV viral RNA synthesis and inhibited EBOV RNA transcription, demonstrating a consistent mechanism of action against genetically distinct viruses. The identification of this chemical backbone as a broad-spectrum inhibitor of viral RNA synthesis offers significant potential for the development of new therapies for highly pathogenic viruses.
C1 [Filone, Claire Marie; Hodges, Erin N.; Honeyman, Brian; Bushkin, G. Guy; Boyd, Karla; Platt, Andrew; Connor, John H.] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA.
[Ni, Feng; Strom, Kyle; Snyder, John K.] Boston Univ, Dept Chem, Boston, MA 02118 USA.
[Ni, Feng; Strom, Kyle; Snyder, John K.] Boston Univ, Ctr Chem Methodol & Lib Dev CMLD BU, Boston, MA 02118 USA.
[Filone, Claire Marie; Hensley, Lisa] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA.
RP Connor, JH (reprint author), Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA.
EM jhconnor@bu.edu
OI Filone, Claire Marie/0000-0002-4041-3948; Connor,
John/0000-0002-8867-7256
FU Postgraduate Research Participation Program; U.S. Army Research and
Medical Command; NIH [RO1AI1096159-01, K22AI-064606]; [P41 086180]
FX We would like to thank Darci Smith for assistance with the RVFV
experiment, Aaron Beeler for his help in coordinating CMLD compound
screening, and Sean Whelan for sharing the VSV minigenome system. We
thank Elke Muhlberger for use of the EBOV minigenome system. C.M.F. was
supported by the Postgraduate Research Participation Program and the
U.S. Army Research and Medical Command administered by the Oak Ridge
Institute for Science and Education (ORISE). This work was supported in
part by P41 086180 and also in part by NIH RO1AI1096159-01 and
K22AI-064606 (to J.H.C.). We thank NSF for supporting the purchase of
the NMR (CHE 0619339) and HRMS (CHE 0443618) spectrometers.
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U1 0
U2 13
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1074-5521
J9 CHEM BIOL
JI Chem. Biol.
PD MAR 21
PY 2013
VL 20
IS 3
BP 424
EP 433
DI 10.1016/j.chembiol.2013.02.011
PG 10
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 115RT
UT WOS:000316830300014
PM 23521799
ER
PT J
AU Serrano, MD
Cascales, C
Han, XM
Zaldo, C
Jezowski, A
Stachowiak, P
Ter-Gabrielyan, N
Fromzel, V
Dubinskii, M
AF Dolores Serrano, Maria
Cascales, Concepcion
Han, Xiumei
Zaldo, Carlos
Jezowski, Andrzej
Stachowiak, Piotr
Ter-Gabrielyan, Nikolay
Fromzel, Viktor
Dubinskii, Mark
TI Thermal Characterization, Crystal Field Analysis and In-Band Pumped
Laser Performance of Er Doped NaY(WO4)(2) Disordered Laser Crystals
SO PLOS ONE
LA English
DT Article
ID LOCAL DISORDER; MU-M; DIODE; OPERATION; ABSORPTION; NM
AB Undoped and Er-doped NaY(WO4)2 disordered single crystals have been grown by the Czochralski technique. The specific heat and thermal conductivity (k) of these crystals have been characterized from T = 4 K to 700 K and 360 K, respectively. It is shown that k exhibits anisotropy characteristic of single crystals as well as a k(T) behavior observed in glasses, with a saturation mean free phonon path of 3.6 angstrom and 4.5 angstrom for propagation along a and c crystal axes, respectively. The relative energy positions and irreducible representations of Stark Er3+ levels up to (4)G7/2 multiplet have been determined by the combination of experimental low (, 10 K) temperature optical absorption and photoluminescence measurements and simulations with a single-electron Hamiltonian including both free-ion and crystal field interactions. Absorption, emission and gain cross sections of the I-4(13/2) < > I-4(15/2) laser related transition have been determined at 77 K. The I-4(13/2) Er3+ lifetime (tau) was measured in the temperature range of 77-300 K, and was found to change from tau (77K) approximate to 4.5 ms to tau (300K) approximate to 3.5 ms. Laser operation is demonstrated at 77 K and 300 K by resonantly pumping the I-4(13/2) multiplet at lambda approximate to 1500 nm with a broadband (FWHM approximate to 20 nm) diode laser source perfectly matching the 77 K crystal I-4(15/2) -> R I-4(13/2) absorption profile. At 77 K as much as 5.5 W of output power were obtained in pi-polarized configuration with a slope efficiency versus absorbed pump power of 57%, the free running laser wavelength in air was lambda approximate to 1611 nm with the laser output bandwidth of 3.5 nm. The laser emission was tunable over 30.7 nm, from 1590.7 nm to 1621.4 nm, for the same pi-polarized configuration.
C1 [Dolores Serrano, Maria; Cascales, Concepcion; Han, Xiumei; Zaldo, Carlos] CSIC, Inst Ciencia Mat Madrid, Dept Photon Mat, Madrid, Spain.
[Jezowski, Andrzej; Stachowiak, Piotr] Polish Acad Sci, Inst Low Temp & Struct Res, Div Low Temp & Superconduct, Wroclaw, Poland.
[Ter-Gabrielyan, Nikolay; Fromzel, Viktor; Dubinskii, Mark] USA, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD USA.
RP Zaldo, C (reprint author), CSIC, Inst Ciencia Mat Madrid, Dept Photon Mat, Madrid, Spain.
EM cezaldo@icmm.csic.es
RI CASCALES, CONCHITA/C-3930-2011; Zalldo, Carlos/K-4321-2013; Serrano,
Maria Dolores/B-9629-2013
OI CASCALES, CONCHITA/0000-0003-2513-5887;
FU USAITC [W911NF-10-1-0234]; Spanish Ministry of Economy and
Competitiveness [MAT2011-29255-C02-01]
FX This work has been partially supported by the USAITC W911NF-10-1-0234
contract and by the Spanish Ministry of Economy and Competitiveness
under project MAT2011-29255-C02-01. The funders had no role in study
design, data collection and analysis, decision to publish, or
preparation of the manuscript.
NR 31
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U1 0
U2 38
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 21
PY 2013
VL 8
IS 3
AR e59381
DI 10.1371/journal.pone.0059381
PG 12
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 111UM
UT WOS:000316546400036
PM 23555664
ER
PT J
AU Nelson, DA
Curran, AR
Nyberg, HA
Marttila, EA
Mason, PA
Ziriax, JM
AF Nelson, David A.
Curran, Allen R.
Nyberg, Hans A.
Marttila, Eric A.
Mason, Patrick A.
Ziriax, John M.
TI High-resolution simulations of the thermophysiological effects of human
exposure to 100 MHz RF energy
SO PHYSICS IN MEDICINE AND BIOLOGY
LA English
DT Article
ID CORE TEMPERATURE ELEVATION; HUMAN VOLUNTEERS; ABSORPTION RATE;
HUMAN-BODY; LOCOREGIONAL HYPERTHERMIA; DIELECTRIC-PROPERTIES; BIOLOGICAL
TISSUES; ESOPHAGEAL CANCER; FDTD CALCULATIONS; VOXEL MODEL
AB Human exposure to radio frequency (RF) electromagnetic energy is known to result in tissue heating and can raise temperatures substantially in some situations. Standards for safe exposure to RF do not reflect bio-heat transfer considerations however. Thermoregulatory function (vasodilation, sweating) may mitigate RF heating effects in some environments and exposure scenarios. Conversely, a combination of an extreme environment (high temperature, high humidity), high activity levels and thermally insulating garments may exacerbate RF exposure and pose a risk of unsafe temperature elevation, even for power densities which might be acceptable in a normothermic environment. A high-resolution thermophysiological model, incorporating a heterogeneous tissue model of a seated adult has been developed and used to replicate a series of whole-body exposures at a frequency (100 MHz) which approximates that of human whole-body resonance. Exposures were simulated at three power densities (4, 6 and 8 mW cm(-2)) plus a sham exposure and at three different ambient temperatures (24, 28 and 31 degrees C). The maximum hypothalamic temperature increase over the course of a 45 min exposure was 0.28 degrees C and occurred in the most extreme conditions (T-amb = 31 degrees C, PD = 8 mW cm(-2)). Skin temperature increases attributable to RF exposure were modest, with the exception of a 'hot spot' in the vicinity of the ankle where skin temperatures exceeded 39 degrees C. Temperature increases in internal organs and tissues were small, except for connective tissue and bone in the lower leg and foot. Temperature elevation also was noted in the spinal cord, consistent with a hot spot previously identified in the literature.
C1 [Nelson, David A.] Univ S Alabama, Dept Mech Engn, Mobile, AL 36688 USA.
[Curran, Allen R.; Nyberg, Hans A.; Marttila, Eric A.] ThermoAnalyt Inc, Calumet, MI 49913 USA.
[Mason, Patrick A.] USA, Res Lab, Directed Energy Bioeffects Div, Radiofrequency Radiat Branch, Brooks City Base, TX 78235 USA.
[Ziriax, John M.] Naval Med Res Unit San Antonio, Brooks City Base, TX 78235 USA.
RP Nelson, DA (reprint author), Univ S Alabama, Dept Mech Engn, Mobile, AL 36688 USA.
EM danelson@southalabama.edu
NR 40
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U1 1
U2 9
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0031-9155
J9 PHYS MED BIOL
JI Phys. Med. Biol.
PD MAR 21
PY 2013
VL 58
IS 6
BP 1947
EP 1968
DI 10.1088/0031-9155/58/6/1947
PG 22
WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging
SC Engineering; Radiology, Nuclear Medicine & Medical Imaging
GA 100WL
UT WOS:000315735400018
PM 23459448
ER
PT J
AU Carlson, LA
Kenefick, RW
Koch, AJ
AF Carlson, Lara A.
Kenefick, Robert W.
Koch, Alexander J.
TI Influence of carbohydrate ingestion on salivary immunoglobulin A
following resistance exercise
SO JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION
LA English
DT Article
DE Carbohydrate; Immunoglobulin (IgA); Cytokines; Immune response;
Resistance exercise
ID INTENSE INTERVAL EXERCISE; ECCENTRIC EXERCISE; CYTOKINE RESPONSE;
IMMUNE-RESPONSES; REPEATED BOUTS; ALPHA-AMYLASE; FLOW-RATE; 2 H; IGA;
SUPPLEMENTATION
AB Background: Heavy exercise stresses immune function, however carbohydrate (CHO) supplementation has been shown to attenuate the decline in some measures of immune function after exercise. The purpose of the study was to investigate the impact of CHO supplementation on salivary immunoglobulin A (s-IgA) levels, interleukin 2 (IL-2), and interleukin 5 (IL-5), following an acute bout of resistance exercise (RE).
Methods: Ten resistance trained male collegiate athletes (21 +/- 2 yr; 174 +/- 6 cm, 80 +/- 11kg, 14%+/- 4% fat) performed RE consisting of four exercises (leg press, lat pull-downs, bench press, and leg curls). Volunteers performed four sets of 10 repetitions at 65% of 1-RM, with 2 min rest between sets for all exercises. Subjects consumed either CHO beverage (1 g.kg(-1) body weight) or placebo (P) prior to, during, and after RE (randomized, double blind design). Saliva and venous blood were collected pre-, post-and 90 min post-exercise.
Results: No change occurred in s-IgA from rest relative to osmolality or as a secretion rate (p > 0.05). IL-2 levels were unchanged by exercise in both trials (time effect p = 0.342). IL-5 was significantly (time effect p = 0.04) decreased between rest (1.55 +/- 0.07 pg.ml(-1)) and 90 min post-exercise (0.96 +/- 0.11 pg.ml(-1)), with no difference between treatments (group x time effect p = 0.610). There was no time-by-treatment interaction (p < 0.05) observed between CHO and P treatments for s-IgA or IL-5.
Conclusion: IL-5 decreases after RE, but s-IgA and IL-2 levels remain stable. CHO ingestion prior to-, during or following RE did not appear to alter salivary immune responses.
C1 [Carlson, Lara A.] Univ New England, Biddeford, ME 04005 USA.
[Kenefick, Robert W.] US Army, Environm Med Res Inst, Natick, MA USA.
[Koch, Alexander J.] Lenoir Rhyne Univ, Hickory, NC USA.
RP Carlson, LA (reprint author), Univ New England, 11 Hills Beach Rd Pickus Biomed Ctr 209, Biddeford, ME 04005 USA.
EM lcarlson@une.edu
FU INBRE Program of the National Center for Research Resources (NCRR), a
component of the National Institutes of Health (NIH) [P20 RR16462]
FX The views, opinions, and findings in this report are those of the
authors and should not be construed as official Department of the Army
position, policy, or decision unless so designated by other official
designation. All experiments were carried out in accordance to state and
federal guidelines. This publication was made possible by the Vermont
Genetics Network through Grant Number P20 RR16462 from the INBRE Program
of the National Center for Research Resources (NCRR), a component of the
National Institutes of Health (NIH). Its contents are solely the
responsibility of the authors and do not necessarily represent the
official views of NCRR or NIH. The authors would like to thank all the
men who participated in this exercise study.
NR 41
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U1 1
U2 5
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1550-2783
J9 J INT SOC SPORT NUTR
JI J. Int. Soc. Sport Nutr.
PD MAR 20
PY 2013
VL 10
AR 14
DI 10.1186/1550-2783-10-14
PG 8
WC Nutrition & Dietetics; Sport Sciences
SC Nutrition & Dietetics; Sport Sciences
GA 190YA
UT WOS:000322378300001
PM 23514330
ER
PT J
AU Dorsey, WM
Zaghloul, AI
AF Dorsey, William Mark
Zaghloul, Amir I.
TI Dual-band, dual-circularly polarised antenna element
SO IET MICROWAVES ANTENNAS & PROPAGATION
LA English
DT Article
ID RECONFIGURABLE MICROSTRIP ANTENNA; DIVERSITY
AB A dual-band element that operates with dual-circular polarisation in two separate industrial, scientific and medical bands is presented. The design that is based on concentric square slot/shorted-ring configuration is realisable in cost-effective printed circuit board technology making it attractive for low-cost personal communications devices. The antenna element provides a flexible topology that allows for convenient, independent control of the polarisation and impedance bandwidth of two distinct frequency bands with no fundamental limitation on the ratio between the high-and low-band frequency ranges. The topology of this element is presented, and the antenna concept is validated via simulated and measured results.
C1 [Dorsey, William Mark] USN, Res Lab, Div Radar, Washington, DC 20375 USA.
[Dorsey, William Mark; Zaghloul, Amir I.] Virginia Polytech Inst & State Univ, Bradley Dept Elect & Comp Engn, Falls Church, VA 22043 USA.
[Zaghloul, Amir I.] USA, Res Lab ARL, Adelphi, MD 20783 USA.
RP Dorsey, WM (reprint author), USN, Res Lab, Div Radar, Washington, DC 20375 USA.
EM wmdorsey@vt.edu
NR 18
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U1 2
U2 16
PU INST ENGINEERING TECHNOLOGY-IET
PI HERTFORD
PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND
SN 1751-8725
EI 1751-8733
J9 IET MICROW ANTENNA P
JI IET Microw. Antennas Propag.
PD MAR 19
PY 2013
VL 7
IS 4
BP 283
EP 290
DI 10.1049/iet-map.2012.0625
PG 8
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA 181YH
UT WOS:000321706200009
ER
PT J
AU Chen, L
Walker, PM
Geissel, H
Litvinov, YA
Beckert, K
Beller, P
Bosch, F
Boutin, D
Caceres, L
Carroll, JJ
Cullen, DM
Cullen, IJ
Franzke, B
Gerl, J
Gorska, M
Jones, GA
Kishada, A
Knobel, R
Kozhuharov, C
Kurcewicz, J
Litvinov, SA
Liu, Z
Mandal, S
Montes, F
Munzenberg, G
Nolden, F
Ohtsubo, T
Patyk, Z
Plass, WR
Podolyak, Z
Rigby, S
Saito, N
Saito, T
Scheidenberger, C
Simpson, EC
Shindo, M
Steck, M
Sun, B
Williams, SJ
Weick, H
Winkler, M
Wollersheim, HJ
Yamaguchi, T
AF Chen, L.
Walker, P. M.
Geissel, H.
Litvinov, Yu. A.
Beckert, K.
Beller, P.
Bosch, F.
Boutin, D.
Caceres, L.
Carroll, J. J.
Cullen, D. M.
Cullen, I. J.
Franzke, B.
Gerl, J.
Gorska, M.
Jones, G. A.
Kishada, A.
Knoebel, R.
Kozhuharov, C.
Kurcewicz, J.
Litvinov, S. A.
Liu, Z.
Mandal, S.
Montes, F.
Muenzenberg, G.
Nolden, F.
Ohtsubo, T.
Patyk, Z.
Plass, W. R.
Podolyak, Zs
Rigby, S.
Saito, N.
Saito, T.
Scheidenberger, C.
Simpson, E. C.
Shindo, M.
Steck, M.
Sun, B.
Williams, S. J.
Weick, H.
Winkler, M.
Wollersheim, H. -J.
Yamaguchi, T.
TI Direct Observation of Long-Lived Isomers in Bi-212
SO PHYSICAL REVIEW LETTERS
LA English
DT Article
ID FRS-ESR FACILITY; NUCLEAR-PHYSICS; DECAY; NUCLEOSYNTHESIS; DEPLETION;
STATES; GSI
AB Long-lived isomers in Bi-212 have been studied following U-238 projectile fragmentation at 670 MeV per nucleon. The fragmentation products were injected as highly charged ions into a storage ring, giving access to masses and half-lives. While the excitation energy of the first isomer of Bi-212 was confirmed, the second isomer was observed at 1478(30) keV, in contrast to the previously accepted value of >1910 keV. It was also found to have an extended Lorentz-corrected in-ring half-life >30 min, compared to 7.0 (3) min for the neutral atom. Both the energy and half-life differences can be understood as being due a substantial, though previously unrecognized, internal decay branch for neutral atoms. Earlier shell-model calculations are now found to give good agreement with the isomer excitation energy. Furthermore, these and new calculations predict the existence of states at slightly higher energy that could facilitate isomer deexcitation studies. DOI: 10.1103/PhysRevLett.110.122502
C1 [Chen, L.; Geissel, H.; Litvinov, Yu. A.; Beckert, K.; Beller, P.; Bosch, F.; Boutin, D.; Caceres, L.; Franzke, B.; Gerl, J.; Gorska, M.; Knoebel, R.; Kozhuharov, C.; Kurcewicz, J.; Litvinov, S. A.; Mandal, S.; Muenzenberg, G.; Nolden, F.; Saito, N.; Saito, T.; Scheidenberger, C.; Steck, M.; Sun, B.; Weick, H.; Winkler, M.; Wollersheim, H. -J.] GSI Helmholtzzentrum Schwerionenforsch, D-64291 Darmstadt, Germany.
[Chen, L.; Geissel, H.; Plass, W. R.; Scheidenberger, C.] Univ Giessen, Inst Phys 2, D-35392 Giessen, Germany.
[Chen, L.] Texas A&M Univ, Inst Cyclotron, College Stn, TX 77843 USA.
[Walker, P. M.; Cullen, I. J.; Jones, G. A.; Liu, Z.; Podolyak, Zs; Simpson, E. C.; Williams, S. J.] Univ Surrey, Dept Phys, Guildford GU2 7XH, Surrey, England.
[Litvinov, Yu. A.] Max Planck Inst Kernphys, D-69117 Heidelberg, Germany.
[Carroll, J. J.] USA, Res Lab, Adelphi, MD 20783 USA.
[Cullen, D. M.; Kishada, A.; Rigby, S.] Univ Manchester, Schuster Lab, Manchester M13 9PL, Lancs, England.
[Liu, Z.] Univ Edinburgh, Sch Phys & Astron, Edinburgh EH9 3JZ, Midlothian, Scotland.
[Montes, F.] Michigan State Univ, E Lansing, MI 48824 USA.
[Ohtsubo, T.] Niigata Univ, Dept Phys, Niigata 9502181, Japan.
[Patyk, Z.] Natl Ctr Nucl Res, PL-00681 Warsaw, Poland.
[Shindo, M.] Univ Tokyo, Dept Phys, Tokyo 1130033, Japan.
[Yamaguchi, T.] Saitama Univ, Grad Sch Sci & Engn, Saitama 3388570, Japan.
RP Chen, L (reprint author), GSI Helmholtzzentrum Schwerionenforsch, Planckstr 1, D-64291 Darmstadt, Germany.
RI CHEN, LIXIN/G-3405-2013; Sun, Baohua/C-6823-2009
OI Sun, Baohua/0000-0001-9868-5711
FU Helmholtz Association of German Research Centers [VH-NG-033]; UK STFC;
AWE plc.; [NSFC-11105010]; [NCET-09-0031]
FX We thank the technical staff of the accelerators, the FRS, and the
target laboratory for their valuable contributions to the beam quality
and experimental setups. We also thank the Helmholtz Association of
German Research Centers (VH-NG-033), and the UK STFC and AWE plc. for
their support. B. S. acknowledges Grants No. NSFC-11105010 and No.
NCET-09-0031.
NR 34
TC 11
Z9 12
U1 0
U2 29
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 0031-9007
J9 PHYS REV LETT
JI Phys. Rev. Lett.
PD MAR 19
PY 2013
VL 110
IS 12
AR 122502
DI 10.1103/PhysRevLett.110.122502
PG 5
WC Physics, Multidisciplinary
SC Physics
GA 109WF
UT WOS:000316399800007
PM 25166798
ER
PT J
AU Belenky, G
Wang, D
Lin, YX
Donetsky, D
Kipshidze, G
Shterengas, L
Westerfeld, D
Sarney, WL
Svensson, SP
AF Belenky, Gregory
Wang, Ding
Lin, Youxi
Donetsky, Dmitry
Kipshidze, Gela
Shterengas, Leon
Westerfeld, David
Sarney, Wendy L.
Svensson, Stefan P.
TI Metamorphic InAsSb/AlInAsSb heterostructures for optoelectronic
applications
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID DEVICES
AB Metamorphic heterostructures containing bulk InAs1-xSbx layers and AlInAsSb barriers were grown on GaSb substrates. The lattice mismatch (up to 2.1%) between the GaSb substrates and the InAsSb layers was accommodated by the growth of GaInSb linearly graded buffers. The 1 mu m thick InAsSb0.44 layer with an absorption edge above 9 mu m exhibited an in-plane residual strain of about 0.08%. InAs1-xSbx structures with x = 0.2 and x = 0.44 operated as light emitting diodes at 80K demonstrated output powers of 90 mu W and 8 mu W at 5 mu m and 8 mu m, respectively. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4796181]
C1 [Belenky, Gregory; Wang, Ding; Lin, Youxi; Donetsky, Dmitry; Kipshidze, Gela; Shterengas, Leon; Westerfeld, David] SUNY Stony Brook, Dept ECE, Stony Brook, NY 11794 USA.
[Sarney, Wendy L.; Svensson, Stefan P.] USA, Res Lab, Adelphi, MD 20783 USA.
RP Belenky, G (reprint author), SUNY Stony Brook, Dept ECE, Stony Brook, NY 11794 USA.
OI LIN, YOUXI/0000-0002-9092-2302
FU US National Science Foundation [DMR1160843]; US Army Research Office
[W911NF1110109, W911NF1220057]
FX This work was supported by US National Science Foundation through grant
(No. DMR1160843) and US Army Research Office through grants (Nos.
W911NF1110109 and W911NF1220057).
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U1 4
U2 50
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0003-6951
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD MAR 18
PY 2013
VL 102
IS 11
AR 111108
DI 10.1063/1.4796181
PG 4
WC Physics, Applied
SC Physics
GA 111TX
UT WOS:000316544900008
ER
PT J
AU Sherwin, J
Gaston, J
AF Sherwin, Jason
Gaston, Jeremy
TI Soldiers and marksmen under fire: monitoring performance with neural
correlates of small arms fire localization
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Article
DE EEG; auditory oddball; expertise; military medicine; military personnel;
generalized linear models (GLMs); source localization
ID INDEPENDENT COMPONENT ANALYSIS; IMPULSE NOISE; BRAIN; EEG; PERCEPTION;
ALGORITHM; ODDBALL
AB Important decisions in the heat of battle occur rapidly and a key aptitude of a good combat soldier is the ability to determine whether he is under fire. This rapid decision requires the soldier to make a judgment in a fraction of a second, based on a barrage of multisensory cues coming from multiple modalities. The present study uses an oddball paradigm to examine listener ability to differentiate shooter locations from audio recordings of small arms fire. More importantly, we address the neural correlates involved in this rapid decision process by employing single-trial analysis of electroencephalography (EEG). In particular, we examine small arms expert listeners as they differentiate the sounds of small arms firing events recorded at different observer position relative to a shooter. Using signal detection theory, we find clear neural signatures related to shooter firing angle by identifying the times of neural discrimination on a trial-to-trial basis. Similar to previous results in oddball experiments, we find common windows relative to the response and the stimulus when neural activity discriminates between target stimuli (forward fire: observer 0 degrees to firing angle) vs. standards(off-axis fire: observer 90 degrees tofiring angle).We also find, using windows of maximum discrimination, that auditory target vs. standard discrimination yields neural sources in Brodmann Area 19(BA19),i.e., in the visual cortex. In summary, we show that single-trial analysis of EEG yields informative scalp distributions and source current localization of discriminating activity when the small arms experts discriminate between forward and off-axis fire observer positions. Furthermore, this perceptual decision implicates brain regions involved in visual processing, even though the task is purely auditory. Finally, we utilize these techniques to quantify the level of expertise in these subjects for the chosen task, having implications for human performance monitoring in combat.
C1 [Sherwin, Jason] Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA.
[Sherwin, Jason; Gaston, Jeremy] USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA.
RP Sherwin, J (reprint author), Columbia Univ, Dept Biomed Engn, 530 West 120th Street Mail Code 8904, New York, NY 10027 USA.
EM jason.sherwin@columbia.edu
FU Army Research Office [W911NF-11-1-0219]; US Army Research Laboratory
Postdoctoral Fellowship Program
FX This work was supported by a grant from the Army Research
Office(W911NF-11-1-0219) and in part by an appointment to the US Army
Research Laboratory Postdoctoral Fellowship Program administered by the
Oak Ridge Associated Universities through a contract with the US Army
Research Laboratory.
NR 33
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PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD MAR 18
PY 2013
VL 7
DI 10.3389/fnhum.2013.00067
PG 14
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA 107XB
UT WOS:000316253100001
ER
PT J
AU Breaud, AR
Henemyre-Harris, CL
Schools, S
Emezienna, N
Clarke, W
AF Breaud, Autumn R.
Henemyre-Harris, Claudia L.
Schools, Sabitha
Emezienna, Nkechinyere
Clarke, William
TI Rapid quantification of the aminoglycoside arbekacin in serum using high
performance liquid chromatography-tandem mass spectrometry
SO CLINICA CHIMICA ACTA
LA English
DT Article
DE Arbekacin; Aminoglycosides; High performance liquid
chromatography-tandem mass spectrometry
ID RESISTANT STAPHYLOCOCCUS-AUREUS; RENAL ACCUMULATION; HUMAN PLASMA;
HPLC-MS/MS; QUANTITATION; IMPACT; MRSA
AB Background: This project entails the development and validation of a method for quantification of the aminoglycoside antibiotic arbekacin in serum using liquid chromatography tandem mass spectrometry (LC-MS/MS) for therapeutic drug monitoring in future clinical trials.
Methods: Following a protein precipitation with 03 mol/l perchloric add containing internal standard dibekacin at a concentration of 0.6 mu g/ml, human serum samples containing arbekacin were analyzed using a Hypersil Gold PIP column and a liquid chromatography system. Elution occurred with a gradient of water and acetonitrile, each containing 0.05% (v/v) trifluoroacetic acid and 0.1% (v/v) formic acid. Analytes were detected over a 325 minute run time using a tandem mass spectrometer with a heated electrospray-ionization (HESI) source in positive ionization mode with selected reaction monitoring (SRM). Matrix effects, carryover, linearity, recovery, precision, and limit of quantification were carefully evaluated.
Results: The limit of quantification for arbekacin was 0.1 mu g/ml. All simple and total precision CV's were less than 62%. The method was linear from 0.1 mu g/ml to 45.9 mu g/ml (slope of 0.973). The mean recovery ranged from 94.7 to 103.8%. No matrix effects were detected.
Conclusions: This developed and validated LC-MS/MS method allows for the quantification of arbekacin in serum following protein precipitation. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Breaud, Autumn R.; Henemyre-Harris, Claudia L.; Schools, Sabitha; Emezienna, Nkechinyere; Clarke, William] Johns Hopkins Sch Med, Dept Pathol, Baltimore, MD USA.
[Henemyre-Harris, Claudia L.] USA, Med Dept Ctr & Sch, Ft Sam Houston, TX USA.
RP Clarke, W (reprint author), 1800 Orleans St,Zayed Tower B1020F, Baltimore, MD 21287 USA.
EM wclarke@jhmi.edu
FU USA MED Research ACQ Activity [W81XWH-11-C-0025]
FX We thank Meiji Seika Kaisha, Ltd. for providing the arbekacin powder. We
also thank Christa Madock and Jennifer Secula from the U.S. Army Medical
Materiel Development Activity for providing several of the reference
documents. This project was funded by USA MED Research ACQ Activity
contract W81XWH-11-C-0025.
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U2 33
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0009-8981
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD MAR 15
PY 2013
VL 418
BP 102
EP 106
DI 10.1016/j.cca.2013.01.004
PG 5
WC Medical Laboratory Technology
SC Medical Laboratory Technology
GA 111OL
UT WOS:000316530500020
PM 23333924
ER
PT J
AU Bashir, IM
Otsyula, N
Awinda, G
Spring, M
Schneider, P
Waitumbi, JN
AF Bashir, Ismail Mahat
Otsyula, Nekoye
Awinda, George
Spring, Michele
Schneider, Petra
Waitumbi, John Njenga
TI Comparison of PfHRP-2/pLDH ELISA, qPCR and Microscopy for the Detection
of Plasmodium Events and Prediction of Sick Visits during a Malaria
Vaccine Study
SO PLOS ONE
LA English
DT Article
ID HISTIDINE-RICH PROTEIN-2; POLYMERASE-CHAIN-REACTION; RAPID
DIAGNOSTIC-TESTS; TIME PCR ASSAY; PREGNANT-WOMEN; LACTATE-DEHYDROGENASE;
ANTIGEN-DETECTION; PLACENTAL MALARIA; PARASITE DENSITY; FALCIPARUM
AB Background: Compared to expert malaria microscopy, malaria biomarkers such as Plasmodium falciparum histidine rich protein-2 (PfHRP-2), and PCR provide superior analytical sensitivity and specificity for quantifying malaria parasites infections. This study reports on parasite prevalence, sick visits parasite density and species composition by different diagnostic methods during a phase-I malaria vaccine trial.
Methods: Blood samples for microscopy, PfHRP-2 and Plasmodium lactate dehydrogenase (pLDH) ELISAs and real time quantitative PCR (qPCR) were collected during scheduled (n = 298) or sick visits (n = 38) from 30 adults participating in a 112-day vaccine trial. The four methods were used to assess parasite prevalence, as well as parasite density over a 42-day period for patients with clinical episodes.
Results: During scheduled visits, qPCR (39.9%, N = 119) and PfHRP-2 ELISA (36.9%, N = 110) detected higher parasite prevalence than pLDH ELISA (16.8%, N = 50) and all methods were more sensitive than microscopy (13.4%, N = 40). All microscopically detected infections contained P. falciparum, as mono-infections (95%) or with P. malariae (5%). By qPCR, 102/119 infections were speciated. P. falciparum predominated either as monoinfections (71.6%), with P. malariae (8.8%), P. ovale (4.9%) or both (3.9%). P. malariae (6.9%) and P. ovale (1.0%) also occurred as co-infections (2.9%). As expected, higher prevalences were detected during sick visits, with prevalences of 65.8% (qPCR), 60.5% (PfHRP-2 ELISA), 21.1% (pLDH ELISA) and 31.6% (microscopy). PfHRP-2 showed biomass build-up that climaxed (1813 +/- 3410 ng/mL SD) at clinical episodes.
Conclusion: PfHRP-2 ELISA and qPCR may be needed for accurately quantifying the malaria parasite burden. In addition, qPCR improves parasite speciation, whilst PfHRP-2 ELISA is a potential predictor for clinical disease caused by P. falciparum.
C1 [Bashir, Ismail Mahat; Otsyula, Nekoye; Awinda, George; Waitumbi, John Njenga] Kenya Govt Med Res Ctr, Walter Reed Project, Kisumu, Kenya.
[Bashir, Ismail Mahat; Spring, Michele] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA.
[Schneider, Petra] Univ Edinburgh, Inst Evolut, Edinburgh, Midlothian, Scotland.
[Schneider, Petra] Univ Edinburgh, Inst Immunol, Edinburgh, Midlothian, Scotland.
[Schneider, Petra] Univ Edinburgh, Inst Infect Res, Edinburgh, Midlothian, Scotland.
RP Waitumbi, JN (reprint author), Kenya Govt Med Res Ctr, Walter Reed Project, Kisumu, Kenya.
EM john.waitumbi@usamru-k.org
OI Schneider, Petra/0000-0002-2616-237X
FU US Agency for International Development (USAID); GlaxoSmithKline
Biologicals (GSK); US Army Medical and Materiel Research Command
(USAMRMC); Office of the Surgeon General, US Army
FX The Study Sponsor was the Office of the Surgeon General, US Army. This
study was funded by the US Agency for International Development (USAID),
with partial support from GlaxoSmithKline Biologicals (GSK) and the US
Army Medical and Materiel Research Command (USAMRMC). The funders had no
role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
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PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 15
PY 2013
VL 8
IS 3
AR e56828
DI 10.1371/journal.pone.0056828
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 109ZC
UT WOS:000316409800004
PM 23554856
ER
PT J
AU Michael, NL
AF Michael, Nelson L.
TI Cooling Off the Host Immune Response to Acute Simian Immunodeficiency
Virus Infection-Is Less More?
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Editorial Material
DE tumor necrosis factor-alpha; Simian immunodefiency virus infection;
HIV/AIDS
ID HIV-INFECTION; T-CELLS; HOMEOSTASIS; FIBROSIS
C1 US Mil HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
RP Michael, NL (reprint author), US Mil HIV Res Program, Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM nmichael@hivresearch.org
NR 9
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U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD MAR 15
PY 2013
VL 207
IS 6
BP 875
EP 876
DI 10.1093/infdis/jis648
PG 2
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 092XO
UT WOS:000315156500001
PM 23100566
ER
PT J
AU Hosur, M
Barua, R
Zainuddin, S
Kumar, A
Trovillion, J
Jeelani, S
AF Hosur, Mahesh
Barua, Rajib
Zainuddin, Shaik
Kumar, Ashok
Trovillion, Jonathan
Jeelani, Shaik
TI Effect of processing techniques on the performance of Epoxy/MWCNT
nanocomposites
SO JOURNAL OF APPLIED POLYMER SCIENCE
LA English
DT Article
DE nanocomposites; multiwalled carbon nanotubes; rheology; thermal
properties; flexure
ID NANOTUBE-REINFORCED EPOXY; WALL CARBON NANOTUBES; MECHANICAL-PROPERTIES;
ELECTRICAL-PROPERTIES; DISPERSION PROCESS; COMPO SITES; POLYMER; MATRIX;
FABRICATION; PURIFICATION
AB The aim of this study is to investigate the optimum technique to disperse Multi-Walled Carbon Nanotubes (MWCNTs) in SC-1 epoxy uniformly and to evaluate the effect of processing technique on the performance of SC-1 epoxy. To achieve better dispersion, MWCNT was mixed with SC-1 resin directly or premixed with a solvent and then mixed with SC-1 resin after evaporating the solvent using sonication, thinky mixing and three-roll mill methods either in isolation or combination. Flexural tests were performed to evaluate mechanical performances and results exhibit up to 27.13, 13.51, and 21.99% improvement on flexural strength, flexural modulus, and maximum strain, respectively, over neat epoxy with only 0.2 wt % loading. Dynamic mechanical analysis (DMA), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) indicated improvement in storage modulus, Tg, inflection temperature, and residue content, respectively over neat SC-1 epoxy. Thermal and mechanical properties at higher loading conditions were seen to either reduce or not significantly improve. This was attributed to high viscosity of nanocomposites as determined by rheological analysis which prevents good dispersion of MWNCTs into epoxy system at 0.4 wt % loading. (c) 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
C1 [Hosur, Mahesh; Zainuddin, Shaik; Jeelani, Shaik] Tuskegee Univ, Mat Sci & Engn Dept, Tuskegee, AL 36088 USA.
[Barua, Rajib; Jeelani, Shaik] Tuskegee Univ, Dept Mech Engn, Tuskegee, AL 36088 USA.
[Kumar, Ashok; Trovillion, Jonathan] USA, Construct Engn Res Lab, Champaign, IL 61821 USA.
RP Hosur, M (reprint author), Tuskegee Univ, Mat Sci & Engn Dept, Tuskegee, AL 36088 USA.
EM hosur@mytu.tuskegee.edu
FU US Army Construction Engineering Research Laboratory [W9132-09-C-0010];
National Science Foundation EPSCoR [1158862]; National Science
Foundation PREM [0611612]
FX Authors acknowledge the support received by US Army Construction
Engineering Research Laboratory through contract # W9132-09-C-0010, and
National Science Foundation EPSCoR Grant # 1158862 and PREM Grant #
0611612.
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U1 0
U2 63
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-8995
J9 J APPL POLYM SCI
JI J. Appl. Polym. Sci.
PD MAR 15
PY 2013
VL 127
IS 6
BP 4211
EP 4224
DI 10.1002/app.37990
PG 14
WC Polymer Science
SC Polymer Science
GA 062RW
UT WOS:000312940400003
ER
PT J
AU Stark, JK
Ding, Y
Kohl, PA
AF Stark, Johanna K.
Ding, Yi
Kohl, Paul A.
TI Role of Dissolved Gas in Ionic Liquid Electrolytes for Secondary Lithium
Metal Batteries
SO JOURNAL OF PHYSICAL CHEMISTRY C
LA English
DT Article
ID ELECTROCHEMICAL PROPERTIES; CONTAMINATED SOLUTIONS; GRAPHITE ANODES;
CARBON-DIOXIDE; SURFACE-FILMS; LI BATTERIES; SOLUBILITIES; ABSORPTION;
INTERFACE; ALLOY
AB Lithium metal is a potential anode in lithium batteries; however, high cycling efficiency has not been achieved. The effect of dissolved gas on the reversibility of a Li/Li+ electrode in an ionic liquid electrolyte was investigated. The ionic liquid electrolyte was saturated with argon, nitrogen, oxygen, air, or carbon dioxide, and the Coulombic efficiency for the reduction and reoxidation of lithium metal was measured. Secondary ion mass spectroscopy (SIMS) was used to determine the thickness and composition of the solid electrolyte interphase (SEI) layer formed on the lithium metal. The Coulombic cycling efficiency was highest with oxygen, nitrogen, and air. The Coulombic efficiency was significantly lower with dissolved carbon dioxide. SIMS revealed that the SEI layer was made up of primarily LiF regardless of the gas used. The thickness of the SEI layer was the main determinant of cycling efficiency. A thinner SEI, observed with nitrogen and oxygen, lead to the highest Coulombic efficiency, whereas carbon dioxide produced a thick SEI that appeared to inhibit lithium deposition.
C1 [Stark, Johanna K.; Kohl, Paul A.] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA.
[Ding, Yi] USA, RDECOM TARDEC, AMSRD TAR R, Warran, MI 48397 USA.
RP Kohl, PA (reprint author), Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA.
EM paul.kohl@chbe.gatech.edu
FU US Army [US001-0000245070]
FX We gratefully acknowledge the financial support of the US Army, contract
US001-0000245070.
NR 31
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U2 89
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1932-7447
J9 J PHYS CHEM C
JI J. Phys. Chem. C
PD MAR 14
PY 2013
VL 117
IS 10
BP 4980
EP 4985
DI 10.1021/jp4001303
PG 6
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA 108PR
UT WOS:000316308400012
ER
PT J
AU Asplund, CA
Best, TM
AF Asplund, Chad A.
Best, Thomas M.
TI Achilles tendon disorders
SO BMJ-BRITISH MEDICAL JOURNAL
LA English
DT Review
ID SHOCK-WAVE TREATMENT; NONOPERATIVE TREATMENT; FOLLOW-UP; ECCENTRIC
EXERCISE; RANDOMIZED-TRIAL; TENDINOPATHY; RUPTURE; INJURY; RISK;
INDIVIDUALS
C1 [Asplund, Chad A.] Eisenhower Army Med Ctr, Dept Family Med, Ft Gordon, GA 30905 USA.
[Best, Thomas M.] Ohio State Univ, Dept Family Med, Div Sports Med, Columbus, OH 43221 USA.
RP Asplund, CA (reprint author), Eisenhower Army Med Ctr, Dept Family Med, Ft Gordon, GA 30905 USA.
EM chad.asplund@gmail.com
NR 66
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U1 1
U2 22
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1756-1833
J9 BMJ-BRIT MED J
JI BMJ-British Medical Journal
PD MAR 12
PY 2013
VL 346
AR f1262
DI 10.1136/bmj.f1262
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA 108VM
UT WOS:000316324300006
PM 23482943
ER
PT J
AU Jhamnani, S
Lassance-Soares, R
Sood, S
Aghili, N
Nashin, H
Hammamieh, R
Chakraborty, N
Burnett, MS
Epstein, S
AF Jhamnani, Sunny
Lassance-Soares, Roberta
Sood, Subeena
Aghili, Nima
Nashin, Hajra
Hammamieh, Rasha
Chakraborty, Nabarun
Burnett, Mary Susan
Epstein, Stephen
TI CHRONIC STRESS ACCELERATES AGING INDUCED COLLATERAL DYSFUNCTION IN
C57BL6 MOUSE MODEL OF HIND LIMB ISCHEMIA
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Meeting Abstract
CT 62nd Annual Scientific Session of the American-College-of-Cardiology
CY MAR 09-11, 2013
CL San Francisco, CA
SP Amer Coll Cardiol
C1 MedStar Hlth Res Inst, Cardiovasc Res Inst, Washington, DC USA.
USA, Ctr Environm Hlth Res, Ft Detrick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0735-1097
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD MAR 12
PY 2013
VL 61
IS 10
SU S
BP E2090
EP E2090
PG 1
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA 111XO
UT WOS:000316555202294
ER
PT J
AU Bandyopadhyay, S
Anderson, J
AF Bandyopadhyay, Saumil
Anderson, John
TI Capacitive infrared photodetector for room temperature operation
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID QUANTUM-DOT; PHOTOCAPACITANCE
AB We report a self-assembled semiconductor nanowire photodetector that detects infrared light at room temperature by registering a change in capacitance upon illumination. Its light-to-dark capacitance ratio exceeds 2.5 at a signal frequency of 75 kHz and gradually decays to 1 beyond 200 kHz. This detector also exhibits "frequency-selectivity" since it is more responsive to photons with energies close to the nanowire's effective bandgap than to higher energy photons. Such a light-sensitive capacitor, unlike a light-sensitive resistor, can be used in a resonant parallel inductor-capacitor circuit to yield giant light-to-dark contrast ratio even when the light-to-dark capacitance ratio is relatively small. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4795520]
C1 [Bandyopadhyay, Saumil] Maggie L Walker Governors Sch Govt & Int Studies, Richmond, VA 23220 USA.
[Bandyopadhyay, Saumil; Anderson, John] USA, Engineer Res & Dev Ctr, Alexandria, VA 22315 USA.
RP Bandyopadhyay, S (reprint author), Maggie L Walker Governors Sch Govt & Int Studies, Richmond, VA 23220 USA.
EM saumilb01@gmail.com
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U1 2
U2 27
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0003-6951
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD MAR 11
PY 2013
VL 102
IS 10
AR 103108
DI 10.1063/1.4795520
PG 4
WC Physics, Applied
SC Physics
GA 111EG
UT WOS:000316501200071
ER
PT J
AU Nayfeh, OM
Birdwell, AG
Tan, C
Dubey, M
Gullapalli, H
Liu, Z
Reddy, ALM
Ajayan, PM
AF Nayfeh, Osama M.
Birdwell, A. Glen
Tan, Cheng
Dubey, Madan
Gullapalli, Hemtej
Liu, Zheng
Reddy, Arava Leela Mohana
Ajayan, Pulickel M.
TI Increased mobility for layer-by-layer transferred chemical vapor
deposited graphene/boron-nitride thin films
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID BORON-NITRIDE; HIGH-QUALITY; SCATTERING; TRANSPORT
AB Large-area chemical vapor deposited graphene/boron-nitride (G/BN) thin films are co-transferred layer-by-layer to silicon-di-Oxide (SiO2) substrates, and transistors are constructed and examined. Raman spectra and high resolution transmission electron microscopy imaging show films of high quality. The graphene/boron-nitride/SiO2 devices have a significantly increased peak electron/hole mobility of 3400/2200 cm(2)/Vs with a reduced effective doping density over reference graphene/SiO2 devices. The mobility dependence as a function of carrier density is compared with a physically based empirical model and is in agreement with the improvements due to a consistent reduction in the substrate induced phonon and impurity scattering and an improvement in the overall surface quality owed to the boron-nitride interlayer that separates the graphene from the SiO2. Large-area G/BN thin films are promising for future high performance thin film electronic devices. [http://dx.doi.org/10.1063/1.4794533]
C1 [Nayfeh, Osama M.; Birdwell, A. Glen; Tan, Cheng; Dubey, Madan] USA, Res Lab ARL, SEDD, Adelphi, MD 20783 USA.
[Gullapalli, Hemtej; Liu, Zheng; Reddy, Arava Leela Mohana; Ajayan, Pulickel M.] Rice Univ, Dept Mech Engn & Mat Sci, Houston, TX 77005 USA.
RP Dubey, M (reprint author), USA, Res Lab ARL, SEDD, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM madan.dubey@us.army.mil; ajayan@rice.edu
RI Liu, Zheng/C-1813-2014; Arava, Leela Mohana Reddy/J-3180-2015;
Gullapalli, Hemtej/P-7247-2014
OI Liu, Zheng/0000-0002-8825-7198; Gullapalli, Hemtej/0000-0003-1520-4287
FU Army Research Lab (ARL) Director's Strategic Initiative (DSI) program on
graphene nanoelectronics; ONR MURI program on graphene
FX The authors acknowledge the support of the Army Research Lab (ARL)
Director's Strategic Initiative (DSI) program on graphene
nanoelectronics. Device processing/characterization and Raman
measurement was performed using the ARL device fabrication and
nano-electronics laboratories. P. M. A. and Z.L. also acknowledge
funding support from the ONR MURI program on graphene. The views and
conclusions contained in this document are those of the authors and
should not be interpreted as representing the official policies, either
expressed or implied, of the ARLor the U. S. Government. The U.S.
Government is authorized to reproduce or distribute reprints for
Government purposes notwithstanding any copyright notation herein.
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U2 98
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0003-6951
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD MAR 11
PY 2013
VL 102
IS 10
AR 103115
DI 10.1063/1.4794533
PG 3
WC Physics, Applied
SC Physics
GA 111EG
UT WOS:000316501200078
ER
PT J
AU Yu, KM
Sarney, WL
Novikov, SV
Detert, D
Zhao, R
Denlinger, JD
Svensson, SP
Dubon, OD
Walukiewicz, W
Foxon, CT
AF Yu, K. M.
Sarney, W. L.
Novikov, S. V.
Detert, D.
Zhao, R.
Denlinger, J. D.
Svensson, S. P.
Dubon, O. D.
Walukiewicz, W.
Foxon, C. T.
TI Highly mismatched N-rich GaN1-xSbx films grown by low temperature
molecular beam epitaxy
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID ALLOYS; BAND
AB We have grown N-rich, dilute Sb GaN1-xSbx alloys by low temperature molecular beam epitaxy. At low growth temperature of <100 degrees C the material loses crystallinity and becomes primarily amorphous with small crystallites of 2-5 nm at a Sb composition of >4 at.%. Despite the different microstructures found for GaN1-xSbx alloys with different composition, the absorption edge shifts continuously from 3.4 eV (GaN) to close to 1 eV for samples with Sb content >30 at. %. GaN1-xSbx alloys with less than 5 at.% Sb show sufficient bandgap reduction (similar to 2 eV), making them suitable for photoelectrochemical applications. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4795446]
C1 [Yu, K. M.; Detert, D.; Zhao, R.; Dubon, O. D.; Walukiewicz, W.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA.
[Sarney, W. L.; Svensson, S. P.; Dubon, O. D.] USA, Res Lab, Adelphi, MD 20783 USA.
[Novikov, S. V.; Foxon, C. T.] Univ Nottingham, Sch Phys & Astron, Nottingham NG7 2RD, England.
[Detert, D.; Zhao, R.] Univ Calif Berkeley, Dept Mat Sci & Engn, Berkeley, CA 94720 USA.
[Denlinger, J. D.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Adv Light Source, Berkeley, CA 94720 USA.
RP Yu, KM (reprint author), Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Mat Sci, 1 Cyclotron Rd, Berkeley, CA 94720 USA.
RI Yu, Kin Man/J-1399-2012
OI Yu, Kin Man/0000-0003-1350-9642
FU US Army [W911NF-12-2-0003]; Office of Science, Office of Basic Energy
Sciences, Materials Sciences and Engineering Division, of the U.S.
Department of Energy [DE-AC02-05CH11231]
FX The MBE growth at the University of Nottingham was undertaken with
support from the EPSRC and by the US Army under Cooperative Agreement
No. W911NF-12-2-0003. RBS and optical measuremnts performed at LBNL were
supported by the Director, Office of Science, Office of Basic Energy
Sciences, Materials Sciences and Engineering Division, of the U.S.
Department of Energy under Contract No. DE-AC02-05CH11231.
NR 12
TC 12
Z9 12
U1 0
U2 12
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0003-6951
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD MAR 11
PY 2013
VL 102
IS 10
AR 102104
DI 10.1063/1.4795446
PG 4
WC Physics, Applied
SC Physics
GA 111EG
UT WOS:000316501200031
ER
PT J
AU Lemasson, BH
Anderson, JJ
Goodwin, RA
AF Lemasson, B. H.
Anderson, J. J.
Goodwin, R. A.
TI Motion-guided attention promotes adaptive communications during social
navigation
SO PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
LA English
DT Article
DE collective behaviour; vision; topological; selective attention; social
information; speed-accuracy trade-offs
ID ANIMAL GROUPS; FISH SCHOOLS; BEHAVIOR; FLOCKS; INFORMATION; ENVIRONMENT;
PERCEPTION; DECISIONS; QUANTITY; DYNAMICS
AB Animals are capable of enhanced decision making through cooperation, whereby accurate decisions can occur quickly through decentralized consensus. These interactions often depend upon reliable social cues, which can result in highly coordinated activities in uncertain environments. Yet information within a crowd may be lost in translation, generating confusion and enhancing individual risk. As quantitative data detailing animal social interactions accumulate, the mechanisms enabling individuals to rapidly and accurately process competing social cues remain unresolved. Here, we model how motion-guided attention influences the exchange of visual information during social navigation. We also compare the performance of this mechanism to the hypothesis that robust social coordination requires individuals to numerically limit their attention to a set of n-nearest neighbours. While we find that such numerically limited attention does not generate robust social navigation across ecological contexts, several notable qualities arise from selective attention to motion cues. First, individuals can instantly become a local information hub when startled into action, without requiring changes in neighbour attention level. Second, individuals can circumvent speed-accuracy trade-offs by tuning their motion thresholds. In turn, these properties enable groups to collectively dampen or amplify social information. Lastly, the minority required to sway a group's short-term directional decisions can change substantially with social context. Our findings suggest that motion-guided attention is a fundamental and efficient mechanism underlying collaborative decision making during social navigation.
C1 [Lemasson, B. H.] USA, Environm Lab, Engineer Res & Dev Ctr, Portland, OR 97208 USA.
[Anderson, J. J.; Goodwin, R. A.] Univ Washington, Sch Aquat & Fishery Sci, Seattle, WA 98195 USA.
RP Lemasson, BH (reprint author), USA, Environm Lab, Engineer Res & Dev Ctr, Portland, OR 97208 USA.
EM brilraven@gmail.com
FU US Army's Network Science research initiative through the US Army
Engineer Research & Development Center's Environmental Quality and
Installations Basic Research Program
FX The authors would like to thank Colby Tanner, Eric Dimperio and Mary
Hunsicker for discussions and constructive comments. We also thank two
anonymous referees for their insightful feedback. Jim Johnson, US Fish
and Wildlife Service-Migratory Bird Management, and Bob Christensen
provided access to the Chiloe Island Shorebird Conservation Program,
which inspired this work. This research was sponsored by the US Army's
Network Science research initiative through the US Army Engineer
Research & Development Center's Environmental Quality and Installations
Basic Research Program. Permission was granted by the Chief of Engineers
to publish this information.
NR 44
TC 8
Z9 9
U1 1
U2 51
PU ROYAL SOC
PI LONDON
PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND
SN 0962-8452
J9 P ROY SOC B-BIOL SCI
JI Proc. R. Soc. B-Biol. Sci.
PD MAR 7
PY 2013
VL 280
IS 1754
AR 20122003
DI 10.1098/rspb.2012.2003
PG 9
WC Biology; Ecology; Evolutionary Biology
SC Life Sciences & Biomedicine - Other Topics; Environmental Sciences &
Ecology; Evolutionary Biology
GA 072IN
UT WOS:000313663700001
PM 23325772
ER
PT J
AU Bell, JC
Wolf, EJ
Schnall, BL
Tis, JE
Tis, LL
Potter, MAJBK
AF Bell, Johanna C.
Wolf, Erik J.
Schnall, Barri L.
Tis, John E.
Tis, Laurie L.
Potter, M. A. J. Benjamin K.
TI Transfemoral Amputations: The Effect of Residual Limb Length and
Orientation on Gait Analysis Outcome Measures
SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
LA English
DT Article
ID ABOVE-KNEE AMPUTATION; SWING-PHASE CONTROL; AMPUTEE GAIT; PROSTHETIC
KNEES; WALKING SPEED; HIP MUSCLES; BIOMECHANICS
AB Background: The level of function achieved following a transfemoral amputation is believed to be affected by surgical attachment of the remaining musculature, resulting orientation of the femur, residual limb length, and eventual prosthetic fit.
Methods: Twenty-six subjects underwent gait analysis testing in the current preferred prosthesis more than twenty-four months postamputation. The femoral length and orientation angles of each subject were measured from standing postoperative radiographic scanograms. The subjects were separated into groups for analysis on the basis of the femoral shaft angles and the residual limb length ratios. Gait analysis was performed to collect kinematic and temporospatial parameters.
Results: A good correlation was observed between residual femoral length and trunk with regard to forward lean (r = -0.683) and lateral flexion (r = -0.628). A good correlation was also observed between residual femoral length and pelvic motion with regard to pelvic tilt (r = -0.691) and obliquity (r = -0.398). A moderate correlation was observed with speed (r = 0.550), indicating that subjects with shorter residual limbs experienced a greater excursion in the torso and pelvis, while walking at a slower self-selected pace. A significant correlation (r = 0.721, p < 0.001) was observed between the femoral shaft abduction angle and the residual femoral length; the shorter the residual limb, the more abducted it was.
Conclusions: The length of the residual femur substantially influences temporospatial and kinematic gait outcomes following transfemoral amputation, and appears to be more important than femoral orientation with regard to these parameters.
C1 [Bell, Johanna C.; Wolf, Erik J.; Schnall, Barri L.; Tis, John E.; Tis, Laurie L.; Potter, M. A. J. Benjamin K.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
RP Bell, JC (reprint author), Walter Reed Natl Mil Med Ctr, Ctr Performance & Clin Res, Amer Bldg 19,B-322,8901 Wisconsin Ave, Bethesda, MD 20889 USA.
EM Johanna.Bell@us.army.mil
OI Wolf, Erik/0000-0002-6353-7978; Potter, MD, Benjamin
K./0000-0002-8771-0317
NR 30
TC 8
Z9 8
U1 0
U2 12
PU JOURNAL BONE JOINT SURGERY INC
PI NEEDHAM
PA 20 PICKERING ST, NEEDHAM, MA 02192 USA
SN 0021-9355
J9 J BONE JOINT SURG AM
JI J. Bone Joint Surg.-Am. Vol.
PD MAR 6
PY 2013
VL 95A
IS 5
BP 408
EP 414
DI 10.2106/JBJS.K.01446
PG 7
WC Orthopedics; Surgery
SC Orthopedics; Surgery
GA AF8MV
UT WOS:000334971200004
PM 23467863
ER
PT J
AU Wang, Y
Mahle, JJ
Furtado, AMB
Glover, TG
Buchanan, JH
Peterson, GW
Levan, MD
AF Wang, Yu
Mahle, John J.
Furtado, Amanda M. B.
Glover, T. Grant
Buchanan, James H.
Peterson, Gregory W.
LeVan, M. Douglas
TI Mass Transfer and Adsorption Equilibrium for Low Volatility Alkanes in
BPL Activated Carbon
SO LANGMUIR
LA English
DT Article
ID SWING FREQUENCY-RESPONSE; BRANCHED HEXANE ISOMERS; MOLECULAR-DYNAMICS;
NORMAL-PARAFFINS; VAPOR-PRESSURE; 5A ZEOLITE; N-DECANE; DIFFUSION;
KINETICS; SEPARATION
AB The structure of a molecule and its concentration can strongly influence diffusional properties for transport in nanoporous materials. We study mass transfer of alkanes in BPL activated carbon using the concentration-swing frequency response method, which can easily discriminate among mass transfer mechanisms. We measure concentration-dependent diffusion rates for n-hexane, n-octane, n-decane, 2,7-dimethyloctane, and cyclodecane, which have different carbon numbers and geometries: straight chain, branched chain, and cyclic. Micropore diffusion is determined to be the controlling mass transfer resistance except at low relative saturation for n-decane, where an external mass transfer resistance also becomes important, showing that the controlling mass transfer mechanism can change with system concentration. Micropore diffusion coefficients are found to be strongly concentration dependent. Adsorption isotherm slopes obtained from measured isotherms, the concentration-swing frequency response method, and a predictive method show reasonably good agreement.
C1 [Wang, Yu; Furtado, Amanda M. B.; LeVan, M. Douglas] Vanderbilt Univ, Dept Chem & Biomol Engn, Nashville, TN 37235 USA.
[Mahle, John J.; Buchanan, James H.; Peterson, Gregory W.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
[Glover, T. Grant] SAIC, Gunpowder, MD 21010 USA.
RP Levan, MD (reprint author), Vanderbilt Univ, VU Stn B 351604, Nashville, TN 37235 USA.
EM m.douglas.levan@vanderbilt.edu
FU U.S. Army ECBC; Defense Threat Reduction Agency (DTRA)
FX We are grateful to the U.S. Army ECBC and the Defense Threat Reduction
Agency (DTRA) for the support of this research.
NR 38
TC 5
Z9 5
U1 1
U2 34
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0743-7463
J9 LANGMUIR
JI Langmuir
PD MAR 5
PY 2013
VL 29
IS 9
BP 2935
EP 2945
DI 10.1021/la304926x
PG 11
WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science,
Multidisciplinary
SC Chemistry; Materials Science
GA 102KS
UT WOS:000315844100017
PM 23360452
ER
PT J
AU Wei, M
Boutwell, RC
Garrett, GA
Goodman, K
Rotella, P
Wraback, M
Schoenfeld, WV
AF Wei, M.
Boutwell, R. C.
Garrett, G. A.
Goodman, K.
Rotella, P.
Wraback, M.
Schoenfeld, W. V.
TI Impact of oxygen source parameters on homoepitaxial ZnO films grown at
low-temperature on Zn-polar substrates
SO JOURNAL OF ALLOYS AND COMPOUNDS
LA English
DT Article
DE ZnO; Molecular beam epitaxy; Homoepitaxy; Oxygen plasma; Atomic force
microscopy
ID MOLECULAR-BEAM EPITAXY; PLASMA; CRYSTAL
AB ZnO thin films were epitaxially grown on Zn-polar (0001) ZnO substrates by plasma-assisted molecular beam epitaxy at a low temperature of 610 degrees C. The influence of Zn/O ratio on the epitaxial growth of ZnO was investigated. By optimizing the Zn/O ratio, a surface root mean square roughness of 0.277 nm with one or two monolayer height steps was achieved at a low growth temperature by growing on ZnO substrates with 0.5 degrees miscut angle toward the [1 (1) over bar 00] axis. Electrostatic ion trapping of the oxygen plasma was found crucial to deflect etching oxygen species at an oxygen flow rate of two standard cubic centimeters per minute, resulting in fewer surface defects and a longer photoluminescence (PL) lifetime of 217 ps. The impact of oxygen source gas purity was studied by high resolution X-ray diffraction and time-resolved photoluminescence (TRPL) measurements of resultant epilayers and higher gas purity was found necessary to reduce non-radiative centers. (C) 2012 Elsevier B. V. All rights reserved.
C1 [Wei, M.; Boutwell, R. C.; Schoenfeld, W. V.] Univ Cent Florida, CREOL, Coll Opt & Photon, Orlando, FL 32816 USA.
[Garrett, G. A.; Goodman, K.; Rotella, P.; Wraback, M.] USA, Res Lab, RDRL SEE M, Adelphi, MD 20783 USA.
RP Schoenfeld, WV (reprint author), Univ Cent Florida, CREOL, Coll Opt & Photon, 4000 Cent Florida Blvd, Orlando, FL 32816 USA.
EM winston@creol.ucf.edu
OI Boutwell, Ryan/0000-0003-2321-1495
FU Army Research Laboratory [W911NF-11-2-0025]
FX The authors would like to acknowledge financial support for this work by
the Army Research Laboratory under Cooperative Agreement Number
W911NF-11-2-0025.
NR 24
TC 14
Z9 14
U1 1
U2 56
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0925-8388
J9 J ALLOY COMPD
JI J. Alloy. Compd.
PD MAR 5
PY 2013
VL 552
BP 127
EP 130
DI 10.1016/j.jallcom.2012.10.034
PG 4
WC Chemistry, Physical; Materials Science, Multidisciplinary; Metallurgy &
Metallurgical Engineering
SC Chemistry; Materials Science; Metallurgy & Metallurgical Engineering
GA 072EZ
UT WOS:000313653300022
ER
PT J
AU Turalska, M
West, BJ
Grigolini, P
AF Turalska, Malgorzata
West, Bruce J.
Grigolini, Paolo
TI Role of committed minorities in times of crisis
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ISING-MODEL; EQUILIBRIUM; SYSTEMS
AB The surprising social phenomena of the Arab Spring and the Occupy Wall Street movement posit the question of whether the active role of committed groups may produce political changes of significant importance. Under what conditions are the convictions of a minority going to dominate the future direction of a society? We address this question with the help of a Cooperative Decision Making model (CDMM) which has been shown to generate consensus through a phase-transition process. We observe that in a system of a finite size the global consensus state is not permanent and times of crisis occur when there is an ambiguity concerning a given social issue. The correlation function within the cooperative system becomes similarly extended as it is observed at criticality. This combination of independence (free will) and long-range correlation makes it possible for very small but committed minorities to produce substantial changes in social consensus.
C1 [Turalska, Malgorzata; West, Bruce J.] Duke Univ, Dept Phys, Durham, NC 27706 USA.
[West, Bruce J.] USA, Informat Sci Directorate, Res Off, Durham, NC USA.
[Grigolini, Paolo] Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA.
RP Turalska, M (reprint author), Duke Univ, Dept Phys, Durham, NC 27706 USA.
EM mat51@phy.duke.edu
FU ARO [W911NF-11-1-0478]
FX MT and PG gratefully acknowledge ARO for the financial support of this
research through grant W911NF-11-1-0478.
NR 26
TC 13
Z9 13
U1 0
U2 22
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAR 4
PY 2013
VL 3
AR 1371
DI 10.1038/srep01371
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 099CC
UT WOS:000315595900001
PM 23455718
ER
PT J
AU Umphres, GD
Roelke, DL
Netherland, MD
AF Umphres, George D.
Roelke, Daniel L.
Netherland, Michael D.
TI The potential algaecide flumioxazin has little effect on growth,
survival and feed conversion of the bluegill sunfish Lepomis macrochirus
SO AQUACULTURE
LA English
DT Article
DE Flumioxazin; Lepomis macrochirus; Prymnesium parvum; Fisheries
management; Algae control
ID ALGA PRYMNESIUM-PARVUM; PHOSPHORUS FERTILIZATION; FISH MORTALITY; BLOOM;
TOXICITY; LAKE; PH; HAPTOPHYTA; SALINITY; DYNAMICS
AB An effective and benign approach to mitigating fish-killing Prymnesium parvum blooms in small impoundments has yet to be identified. The aquatic herbicide flumioxazin (Clipper (R), Valent Corp., Walnut Creek, CA), however, shows promise as it suppresses P. parvum while having little effect on other plankton. Its influence on fish has yet to be evaluated. Here, we investigated potential effects of flumioxazin on growth, survival and feed conversion ratio of a non-target organism, bluegill sunfish (Lepomis macrochirus) in a laboratory experiment. We exposed fish to several herbicide concentrations that spanned the manufacturer's recommended dosage (0, 25, 50, 100, 200 and 400 mu g L-1). The duration of the experiment was six weeks with weekly re-application of flumioxazin to specified tanks. No significant differences were found in average fish weight gain (p=0.76), percent survival of fish (p=0.83) or the feed conversion ratio (p=0.89). These findings provide further evidence that flumioxazin application may be an effective and benign approach to P. parvum mitigation. (C) 2012 Elsevier B. V. All rights reserved.
C1 [Umphres, George D.; Roelke, Daniel L.] Texas A&M Univ, Dept Wildlife & Fisheries Sci, College Stn, TX 77843 USA.
[Roelke, Daniel L.] Texas A&M Univ, Dept Oceanog, College Stn, TX 77843 USA.
[Netherland, Michael D.] USA, Erdc, Gainesville, FL 32653 USA.
RP Roelke, DL (reprint author), Texas A&M Univ, Dept Oceanog, College Stn, TX 77843 USA.
EM droelke@tamu.edu
RI Roelke, Daniel/B-5766-2008
NR 33
TC 1
Z9 1
U1 0
U2 27
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0044-8486
J9 AQUACULTURE
JI Aquaculture
PD MAR 4
PY 2013
VL 380
BP 80
EP 83
DI 10.1016/j.aquaculture.2012.11.035
PG 4
WC Fisheries; Marine & Freshwater Biology
SC Fisheries; Marine & Freshwater Biology
GA 085VR
UT WOS:000314642900013
ER
PT J
AU Hinton, L
Hargrave, R
Ahmed, I
Jimenez, DE
AF Hinton, Ladson
Hargrave, Rita
Ahmed, Iqbal Ike
Jimenez, Daniel E.
TI OVERVIEW AND USE OF DSM-5 CULTURAL FORMULATION IN OLDER ADULTS
SO AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Association-for-Geriatric-Psychiatry
CY MAR 14-17, 2013
CL Los Angeles, CA
SP Amer Assoc Geriatr Psychiat
C1 [Hinton, Ladson; Hargrave, Rita] Univ Calif Davis, Sacramento, CA USA.
[Jimenez, Daniel E.] Dartmouth, Hanover, NH USA.
[Ahmed, Iqbal Ike] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
[Ahmed, Iqbal Ike] Univ Hawaii, Honolulu, HI 96822 USA.
[Hargrave, Rita] VA No Calif Hlth Care Syst, Martinez, CA USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1064-7481
EI 1545-7214
J9 AM J GERIAT PSYCHIAT
JI Am. J. Geriatr. Psychiatr.
PD MAR
PY 2013
VL 21
IS 3
SU S
BP S27
EP S27
PG 1
WC Geriatrics & Gerontology; Gerontology; Psychiatry
SC Geriatrics & Gerontology; Psychiatry
GA 298XQ
UT WOS:000330358400035
ER
PT J
AU Risinger, JI
Alkas, A
Hood, BL
Liu, BQ
Challa, R
Shoji, Y
Wang, GS
Chandramouli, GVR
Fazleabas, A
Ferguson, S
Zahn, C
Maxwell, GL
Conrads, TP
AF Risinger, John I.
Alkas, Addie
Hood, Brian L.
Liu, Baoquan
Challa, Rusheeswar
Shoji, Yutaka
Wang, Guisong
Chandramouli, Gadisetti V. R.
Fazleabas, Asgerally
Ferguson, Susan
Zahn, Christopher
Maxwell, G. Larry
Conrads, Thomas P.
TI Unbiased Mass Spectrometry Based Identification of Proteins of the
Uterine Epithelium and Stroma Discriminates between the Proliferative
and Secretory Phases of the Menstrual Cycle
SO REPRODUCTIVE SCIENCES
LA English
DT Meeting Abstract
CT 60th Annual Scientific Meeting of the
Society-for-Gynecologic-Investigation (SGI)
CY MAR 20-23, 2013
CL Orlando, FL
SP Soc Gynecol Invest
C1 [Risinger, John I.; Liu, Baoquan; Challa, Rusheeswar; Shoji, Yutaka; Chandramouli, Gadisetti V. R.; Fazleabas, Asgerally; Ferguson, Susan] Michigan State Univ, Dept OB GYN & Reprod Biol, Grand Rapids, MI USA.
[Alkas, Addie; Zahn, Christopher] Walter Reed Army Med Ctr, Dept OB GYN, Washington, DC 20307 USA.
[Hood, Brian L.; Wang, Guisong; Maxwell, G. Larry; Conrads, Thomas P.] Inova Hlth Syst, Womens Hlth Integrated Res Ctr, Annandale, VA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1933-7191
EI 1933-7205
J9 REPROD SCI
JI Reprod. Sci.
PD MAR
PY 2013
VL 20
IS S3
SU 3
BP 228A
EP 228A
PG 1
WC Obstetrics & Gynecology; Reproductive Biology
SC Obstetrics & Gynecology; Reproductive Biology
GA 287LK
UT WOS:000329543100560
ER
PT J
AU Farrell, KW
AF Farrell, Kevin W.
TI The Arc of War: Origins, Escalation, and Transformation
SO JOURNAL OF WORLD HISTORY
LA English
DT Book Review
C1 [Farrell, Kevin W.] US Mil Acad, West Point, NY 10996 USA.
RP Farrell, KW (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 2
TC 0
Z9 0
U1 0
U2 0
PU UNIV HAWAII PRESS
PI HONOLULU
PA 2840 KOLOWALU ST, HONOLULU, HI 96822 USA
SN 1045-6007
EI 1527-8050
J9 J WORLD HIST
JI J. World Hist.
PD MAR
PY 2013
VL 24
IS 1
BP 179
EP 181
PG 3
WC History
SC History
GA 284PQ
UT WOS:000329332800007
ER
PT J
AU Sperry, JH
Ward, MP
Weatherhead, PJ
AF Sperry, Jinelle H.
Ward, Michael P.
Weatherhead, Patrick J.
TI Effects of Temperature, Moon Phase, and Prey on Nocturnal Activity in
Ratsnakes: An Automated Telemetry Study
SO JOURNAL OF HERPETOLOGY
LA English
DT Article
ID DAILY ACTIVITY PATTERNS; ELAPHE OBSOLETA; BLACK RATSNAKES; SEASONAL
ACTIVITY; PREDATION RISK; HABITAT USE; SNAKE; MOONLIGHT; ECOLOGY;
AVAILABILITY
AB Nocturnal activity is important for many animals, but difficulty in documenting that activity has hampered efforts to understand factors that influence when animals are active at night. We used automated radiotelemetry to provide the first detailed tests of the hypothesis that the nocturnal activity of free-ranging snakes should be influenced by temperature, moon phase, and prey abundance by using data for Ratsnakes (Pantherophis spp.) from Texas and Illinois. Ratsnakes exhibited some nocturnal behavior throughout their active season in both Texas and Illinois, although snakes were much more active at night in Texas than in Illinois. Texas snakes transitioned from primarily diurnal activity to primarily nocturnal activity over this snake's active season, whereas Illinois snakes were always most active in the middle of the day. For both populations, nocturnal activity was positively related to temperature but unrelated to moon phase. Ratsnakes in Texas exhibited a stepwise increase in nocturnal activity in mid-summer, independent of temperature and coincident with the shift in their diet to almost exclusively mammals active at night. Given the ability of snakes in both populations to be active at night when temperatures allow, warming climates could lead to an increase in nocturnal activity, with consequences for both the snakes and the species on which they prey.
C1 [Sperry, Jinelle H.] Engineer Res & Dev Ctr, Champaign, IL 61826 USA.
[Ward, Michael P.; Weatherhead, Patrick J.] Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA.
RP Sperry, JH (reprint author), Engineer Res & Dev Ctr, POB 9005, Champaign, IL 61826 USA.
EM jinelle.sperry@usace.army.mil
FU U.S. Army; Army Corps of Engineers Engineer Research and Development
Center
FX For the Texas portion of this project we thank the U.S. Army and the
Army Corps of Engineers Engineer Research and Development Center for
funding, particularly J. Cornelius, T. Hayden, and T. Buchanan. We also
thank C. Taylor and numerous other biologists for assistance in the
field. For the Illinois portion we thank M. Alessi, H. Fraser, K.
Sierzega, S. Chiavacci, T. Dallas, T. Beveroth, A. Raim, Vermilion
County Conservation District, and the Illinois Department of Natural
Resources for assistance in the field and access to the study area. We
thank T. J. Benson for assistance with statistical analyses.
NR 51
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U1 2
U2 34
PU SOC STUDY AMPHIBIANS REPTILES
PI ST LOUIS
PA C/O ROBERT D ALDRIDGE, ST LOUIS UNIV, DEPT BIOLOGY, 3507 LACLEDE, ST
LOUIS, MO 63103 USA
SN 0022-1511
EI 1937-2418
J9 J HERPETOL
JI J. Herpetol.
PD MAR
PY 2013
VL 47
IS 1
BP 105
EP 111
DI 10.1670/11-325
PG 7
WC Zoology
SC Zoology
GA 264TG
UT WOS:000327903300015
ER
PT J
AU Ponlawat, A
Fansiri, T
Kurusarttra, S
Pongsiri, A
McCardle, PW
Evans, BP
Richardson, JH
AF Ponlawat, Alongkot
Fansiri, Thanyalak
Kurusarttra, Somwang
Pongsiri, Arissara
McCardle, Patrick W.
Evans, Brain P.
Richardson, Jason H.
TI DEVELOPMENT AND EVALUATION OF A PYRIPROXYFEN-TREATED DEVICE TO CONTROL
THE DENGUE VECTOR, AEDES AEGYPTI (L.) (DIPTERA:CULICIDAE)
SO SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH
LA English
DT Article
DE Aedes aegypti; pyriproxyfen; mosquito control; dengue; chikungunya
ID LARVICIDE BACILLUS-SPHAERICUS; GROWTH-REGULATOR PYRIPROXYFEN;
COMPARATIVE EFFICACY; LARVAL HABITATS; LETHAL OVITRAP; MOSQUITOS;
EMBRYOGENESIS; SURVEILLANCE; OVIPOSITION; COLLECTION
AB The resurgence of dengue fever and the chikungunya epidemic make the control of Aedes aegypti mosquitoes, the vectors of these diseases, critically important. We developed and evaluated an Ae. aegypti control device that is visually-attractive to mosquitoes. This pyriproxyfen-treated device was evaluated for its impact on Ae. aegypti egg production and population dynamics in dengue-endemic areas in Thailand. The device consists of a "high rise" shaped ovitrap/resting station covered with black cotton cloth. The device is easily collapsible and transportable. Ae. aegypti are generally drawn towards darker, shadier areas making this device physically attractive as a resting station to mosquitoes of all physiological stages. The results show this device suppressed Ae. aegypti populations after it was introduced into a village. The observed effect was primarily the result of the Ae. aegypti exposure to pyriproxyfen shortly after adult emergence or after taking a blood meal resulting in decreased egg production. We believe the device may be further improved physically and the formulation should be replaced to provide even better efficacy for controlling Ae. aegypti mosquito populations.
C1 [Ponlawat, Alongkot; Fansiri, Thanyalak; Kurusarttra, Somwang; Pongsiri, Arissara; McCardle, Patrick W.; Evans, Brain P.; Richardson, Jason H.] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand.
[Richardson, Jason H.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD USA.
RP Ponlawat, A (reprint author), Armed Forces Res Inst Med Sci, Dept Entomol, 315-6 Ratchawithi Rd, Bangkok 10400, Thailand.
EM AlongkotP@afrims.org
FU Deployed War-fighter Protection Research Program (DWFP)
FX We acknowledge the excellent support of the entomology staff of the
Vector Borne Disease Control Center (VBDC) 3.3 Rayong Province,
especially Wanna P and Prawat C for assistance and data collection. We
thank Somporn. C, Somsak T, Opas T, Prasan K, Chanyapat N, and
Wachiraphan. C from Vector Biology and Control Section, Department of
Entomology, USAMC-AFRIMS for the technical assistance. We would like to
thank the health volunteers, and villagers from the study sites for
allowing us to collect Ae. aegypti in their homes. We acknowledge
Sumitomo Company, Thailand, for providing the pyriproxyfen used in the
current study. We are grateful to Dr Michelle Helinski, Dr Lauren Cator
and Harrington's laboratory members, Cornell University for the critical
review of this manuscript. This work was funded by the Deployed
War-fighter Protection Research Program (DWFP).
NR 28
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U2 5
PU SOUTHEAST ASIAN MINISTERS EDUC ORGANIZATION
PI BANGKOK
PA SEAMEO-TROPMED, 420-6 RAJVITHI RD,, BANGKOK 10400, THAILAND
SN 0125-1562
J9 SE ASIAN J TROP MED
JI Southeast Asian J. Trop. Med. Public Health
PD MAR
PY 2013
VL 44
IS 2
BP 167
EP 178
PG 12
WC Public, Environmental & Occupational Health; Infectious Diseases;
Tropical Medicine
SC Public, Environmental & Occupational Health; Infectious Diseases;
Tropical Medicine
GA 254NC
UT WOS:000327171400005
PM 23691625
ER
PT J
AU Wichit, S
Yongpradoem, H
Surasombatpattana, P
Leaungwuttiwong, P
Kalambaheti, T
Jampangern, W
Jittmittraphap, A
AF Wichit, Sineewanlaya
Yongpradoem, Hatairat
Surasombatpattana, Pornapat
Leaungwuttiwong, Pornsawan
Kalambaheti, Thareerat
Jampangern, Wipawee
Jittmittraphap, Akanitt
TI CLONING AND APPLICATION OF RECOMBINANT DENGUE VIRUS M-PR-M PROTEIN FOR
SERODIAGNOSIS OF DENGUE VIRUS INFECTION
SO SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH
LA English
DT Article
DE dengue virus; prM-M; recombinant protein; ELISA; Western blot
ID EVOLUTION
AB We studied the use of the precursor to the M structural protein (prM) found only on the surface of mature dengue virus as a target protein to detect dengue virus infection. Recombinant D2-16681 prM-M protein was constructed and tested for immunogenicity with dengue and Japanese encephalitis patient sera by Western blot analysis and indirect ELISA. The sensitivity and specificity of indirect ELISA were 48.1 and 85.5%, respectively, and Western blot assay were 23.1 and 98.7%, respectively, for detection of dengue virus. Although the sensitivity of the indirect ELISA is low, the indirect ELISA using recombinant D2-16681 prM-M proteins as antigen may be used for early detection of dengue virus infection.
C1 [Wichit, Sineewanlaya; Yongpradoem, Hatairat; Surasombatpattana, Pornapat; Leaungwuttiwong, Pornsawan; Kalambaheti, Thareerat; Jampangern, Wipawee; Jittmittraphap, Akanitt] Mahidol Univ, Dept Microbiol & Immunol, Fac Trop Med, Bangkok 10400, Thailand.
[Wichit, Sineewanlaya] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
RP Jittmittraphap, A (reprint author), Mahidol Univ, Dept Microbiol & Immunol, Fac Trop Med, 420-6 Ratchawithi Rd, Bangkok 10400, Thailand.
EM akanitt.jit@mahidol.ac.th
FU Department of Microbiology and Immunology, Faculty of Tropical Medicine,
Mahidol University, Thailand
FX This study was supported by the Department of Microbiology and
Immunology, Faculty of Tropical Medicine, Mahidol University, Thailand.
We thank the Department of Virology, Armed Forces Research Institute of
Medical Sciences (AFRIMS) for the serological diagnosis. We also would
like to thank the public health inspector, director of the hospital and
the staff in Nong Khai and Nakhon Phanom Provinces.
NR 11
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U1 1
U2 3
PU SOUTHEAST ASIAN MINISTERS EDUC ORGANIZATION
PI BANGKOK
PA SEAMEO-TROPMED, 420-6 RAJVITHI RD,, BANGKOK 10400, THAILAND
SN 0125-1562
J9 SE ASIAN J TROP MED
JI Southeast Asian J. Trop. Med. Public Health
PD MAR
PY 2013
VL 44
IS 2
BP 218
EP 225
PG 8
WC Public, Environmental & Occupational Health; Infectious Diseases;
Tropical Medicine
SC Public, Environmental & Occupational Health; Infectious Diseases;
Tropical Medicine
GA 254NC
UT WOS:000327171400011
PM 23691631
ER
PT J
AU Bodhidatta, L
Srijan, A
Serichantalergs, O
Bangtrakulnonth, A
Wongstitwilairung, B
McDaniel, P
Mason, CJ
AF Bodhidatta, Ladaporn
Srijan, Apichai
Serichantalergs, Oralak
Bangtrakulnonth, Aroon
Wongstitwilairung, Boonchai
McDaniel, Philip
Mason, Carl J.
TI BACTERIAL PATHOGENS ISOLATED FROM RAW MEAT AND POULTRY COMPARED WITH
PATHOGENS ISOLATED FROM CHILDREN IN THE SAME AREA OF RURAL THAILAND
SO SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH
LA English
DT Article
DE Campylobacter; Salmonella; Arcobacter; diarrhea; food; Thailand
ID CAMPYLOBACTER-JEJUNI; RESISTANT SALMONELLA; ARCOBACTER-BUTZLERI; FOODS;
SEROVARS; HUMANS; IDENTIFICATION; CONTAMINATION; CONSEQUENCES;
HELICOBACTER
AB To better understand the epidemiology of bacterial food borne pathogens in children, in relation to pathogens in meats from a market in rural Thailand, we collected 73 cultures samples from raw chicken, pork and fish at a local market where diarrheal disease surveillance was conducted. Standard methods were employed to isolate, identify and serotype enteric pathogens from children and food samples. Antibiotic susceptibility testing was performed. Ninety-seven percent of food samples were contaminated with at least one enteric pathogen. The pathogens most commonly isolated from food were Salmonella spp (84%), Arcobacter butzleri (74%) and Campylobacter spp (51%). The most common serovars of Salmonella obtained from humans with diarrhea were S. Risen, S. Stanley and S. Anatum. Most common serovars of Salmonella isolated from food were S. Anatum, S. Stanley, and S. Corvallis. Fifty-one percent and 25% of children infected with Salmonella and Campylobacter, respectively, infected with the same serotypes isolated from food samples, suggesting these pathogens are widespread in food and humans. Pulsed-field gel analysis of Salmonella spp revealed 65 pulsotypes, but no point-sources of salmonellosis were identified. Joint epidemiologic/laboratory studies are useful to describe the epidemiology of enteric pathogens in rural populations.
C1 [Bodhidatta, Ladaporn; Srijan, Apichai; Serichantalergs, Oralak; Wongstitwilairung, Boonchai; Mason, Carl J.] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand.
[Bangtrakulnonth, Aroon] World Hlth Org WHO Natl Salmonella & Shigella Ctr, Bangkok, Thailand.
[McDaniel, Philip] Kwai River Christian Hosp KRCH, Sangkhla Buri, Kanchanaburi, Thailand.
RP Bodhidatta, L (reprint author), Armed Forces Res Inst Med Sci, Dept Enter Dis, 315-6 Ratchawithi Rd, Bangkok 10400, Thailand.
EM ladapornb@afrims.org
FU Armed Forces Health Surveillance Center-Global Emerging Infections
Surveillance and Response System (AFHSC-GEIS), Washington, DC, USA
FX We are thankful to the staff of the Enteric Diseases Department, AFRIMS,
Bangkok, for bacterial identification, collection and molecular typing.
This work was supported by the Armed Forces Health Surveillance
Center-Global Emerging Infections Surveillance and Response System
(AFHSC-GEIS), Washington, DC, USA.
NR 37
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U1 0
U2 2
PU SOUTHEAST ASIAN MINISTERS EDUC ORGANIZATION
PI BANGKOK
PA SEAMEO-TROPMED, 420-6 RAJVITHI RD,, BANGKOK 10400, THAILAND
SN 0125-1562
J9 SE ASIAN J TROP MED
JI Southeast Asian J. Trop. Med. Public Health
PD MAR
PY 2013
VL 44
IS 2
BP 259
EP 272
PG 14
WC Public, Environmental & Occupational Health; Infectious Diseases;
Tropical Medicine
SC Public, Environmental & Occupational Health; Infectious Diseases;
Tropical Medicine
GA 254NC
UT WOS:000327171400016
PM 23691636
ER
PT J
AU Stratman, KN
Overholt, WA
Cuda, JP
Netherland, MD
Wilson, PC
AF Stratman, K. N.
Overholt, W. A.
Cuda, J. P.
Netherland, M. D.
Wilson, P. C.
TI Host range and searching behaviour of Cricotopus lebetis (Diptera:
Chironomidae), a tip miner of Hydrilla verticillata (Hydrocharitaceae)
SO BIOCONTROL SCIENCE AND TECHNOLOGY
LA English
DT Article
DE weed biological control; host finding; random search; aquatic
olfactometer
ID PHYTOPHAGOUS INSECTS; OVIPOSITION; PERFORMANCE; PREFERENCE
AB A chironomid midge, Cricotopus lebetis Sublette (Diptera: Chironomidae), was discovered feeding on Hydrilla verticillata (L.f.) Royle (Hydrocharitaceae) in Crystal River, Citrus, Co., Florida, in the 1990s. Larvae of the midge mine the apical meristems of hydrilla, causing terminal branching and stunting of the plant. We investigated the fundamental host range of the midge by conducting a series of no-choice and paired-choice tests. No-choice developmental tests with neonate larvae revealed that the fundamental host range of C. lebetis included not only on hydrilla but also several other aquatic plants in different families, suggesting that this insect is not a hydrilla specialist. In paired-choice bioassays, larval colonisation of Elodea canadensis Michx. (Hydrocharitaceae) and Najas guadalupensis (Spreng.) Magnus (Najadaceae) was greater than colonisation of H. verticillata. Behavioural bioassays in a Y-tube olfactometer and in Petri dishes suggested that neonate larvae were not able to locate host plant material, whereas older larvae were successful in finding hosts. In paired-choice oviposition tests, adult females discriminated between potential oviposition sites, with greater numbers of eggs laid on E. canadensis and N. guadalupensis than on H. verticillata. This study is the first detailed account of host searching and oviposition behaviour of a phytophagous chironomid midge. The results will be used to assess the potential value of C. lebetis as a biological control agent of hydrilla.
C1 [Stratman, K. N.; Overholt, W. A.; Wilson, P. C.] Univ Florida, Indian River Res & Educ Ctr, Ft Pierce, FL USA.
[Cuda, J. P.] Univ Florida, Dept Entomol & Nematol, Gainesville, FL 32611 USA.
[Netherland, M. D.] Ctr Aquat & Invas Plants, US Army Engn Res & Dev Ctr, Gainesville, FL USA.
RP Overholt, WA (reprint author), Univ Florida, Indian River Res & Educ Ctr, Ft Pierce, FL USA.
EM billover@ufl.edu
FU USDA Hydrilla IPM RAMP grant; Florida Fish and Wildlife Conservation
Commission
FX We thank the USDA Hydrilla IPM RAMP grant and the Florida Fish and
Wildlife Conservation Commission for providing financial support for
this research. We also thank Dana Denson, Robert Rutter and Doug Strom
for sharing their C. lebetis collection records and John Epler for
assistance with the identification of chironomids. A special thanks to
Niels Brouwers for help with fitting our data to the correlated random
walk model. We also thank the staff at the Biological Control Research
and Containment laboratory in Fort Pierce, Florida, for assistance with
insect rearing and experiments.
NR 33
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U1 0
U2 14
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0958-3157
EI 1360-0478
J9 BIOCONTROL SCI TECHN
JI Biocontrol Sci. Technol.
PD MAR 1
PY 2013
VL 23
IS 3
BP 317
EP 334
DI 10.1080/09583157.2012.757297
PG 18
WC Biotechnology & Applied Microbiology; Entomology
SC Biotechnology & Applied Microbiology; Entomology
GA 243XP
UT WOS:000326352000006
ER
PT J
AU Grooms, DR
Grindstaff, TL
Croy, T
Hart, JM
Saliba, SA
AF Grooms, Dustin R.
Grindstaff, Terry L.
Croy, Theodore
Hart, Joseph M.
Saliba, Susan A.
TI Clinimetric Analysis of Pressure Biofeedback and Transversus Abdominis
Function in Individuals With Stabilization Classification Low Back Pain
SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
LA English
DT Article
DE lumbar stabilization; sonography; trunk control
ID DRAWING-IN MANEUVER; M-MODE ULTRASOUND; MUSCLE THICKNESS; INTRAABDOMINAL
PRESSURE; ELECTROMYOGRAPHIC ACTIVITY; SURFACE ELECTROMYOGRAPHY;
HOLLOWING EXERCISES; TRUNK MUSCLES; LUMBAR SPINE; CONTRACTION
AB STUDY DESIGN: Descriptive laboratory study.
OBJECTIVE: To determine if a proposed clinical test (pressure biofeedback) could detect changes in transversus abdominis (TrA) muscle thickness during an abdominal drawing-in maneuver.
BACKGROUND: Pressure biofeedback may be used to assess abdominal muscle function and TrA activation during an abdominal drawing-in maneuver but has not been validated.
METHODS: Forty-nine individuals (18 men, 31 women) with low back pain who met stabilization classification criteria underwent ultrasound imaging to quantify changes in TrA muscle thickness while a pressure transducer was used to measure pelvic and spine position during an abdominal drawing-in maneuver. A paired t test was used to compare differences in TrA activation ratios between groups (able or unable to maintain pressure of 40 5 mmHg). The groups were further dichotomized based on TrA activation ratio (high, greater than 1.5; low, less than 1.5). Sensitivity, specificity, and likelihood ratios were calculated.
RESULTS: There was not a significant difference (P = .57) in TrA activation ratios (able to maintain pressure, 1.59 +/- 0.28; unable to maintain pressure, 1.54 +/- 0.24) between groups. The pressure biofeedback test had low sensitivity of 0.22 (95% confidence interval [CI]: 0.10, 0.42) but moderate specificity of 0.77 (95% CI: 0.58, 0.89), a positive likelihood ratio of 0.94(95% CI: 0.33, 2.68), and a negative likelihood ratio of 1.02(95% CI: 0.75, 1.38).
CONCLUSION: Successful completion on pressure biofeedback does not indicate high TrA activation. Unsuccessful completion on pressure biofeedback may be more indicative of low TrA activation, but the correlation and likelihood coefficients indicate that the pressure test is likely of minimal value to detect TrA activation.
C1 [Grooms, Dustin R.] Ohio State Univ, Sch Hlth & Rehabil Sci, Columbus, OH 43210 USA.
[Grindstaff, Terry L.] Creighton Univ, Dept Phys Therapy, Omaha, NE 68178 USA.
[Croy, Theodore] US Army Baylor Univ, US Army Med Specialist Corps, Doctoral Program Phys Therapy, Ft Sam Houston, TX USA.
[Hart, Joseph M.; Saliba, Susan A.] Univ Virginia, Dept Human Serv, Kinesiol Program, Charlottesville, VA USA.
RP Grooms, DR (reprint author), Ohio State Univ, Sch Hlth & Rehabil Sci, 453 West 10th Ave,228C Atwell Hall, Columbus, OH 43210 USA.
EM Grooms.69@osu.edu
OI Saliba, Susan/0000-0001-7179-8310; Hart, Joe/0000-0002-0410-5112
NR 71
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U1 0
U2 9
PU J O S P T,
PI ALEXANDRIA
PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA
SN 0190-6011
J9 J ORTHOP SPORT PHYS
JI J. Orthop. Sports Phys. Ther.
PD MAR
PY 2013
VL 43
IS 3
BP 184
EP 193
DI 10.2519/jospt.2013.4397
PG 10
WC Orthopedics; Rehabilitation; Sport Sciences
SC Orthopedics; Rehabilitation; Sport Sciences
GA 236FR
UT WOS:000325781400010
PM 23160344
ER
PT J
AU Waksman, A
Sethumadhavan, S
Eum, J
AF Waksman, Adam
Sethumadhavan, Simha
Eum, Julianna
TI Practical, Lightweight Secure Inclusion of Third-Party Intellectual
Property
SO IEEE DESIGN & TEST
LA English
DT Article
C1 [Waksman, Adam; Sethumadhavan, Simha] Columbia Univ, Comp Architecture & Secur Technol Lab, New York, NY 10027 USA.
[Eum, Julianna] US Mil Acad, CRC, West Point, NY USA.
RP Waksman, A (reprint author), Columbia Univ, Dept Comp Sci, Comp Architecture & Secur Technol Lab, New York, NY 10027 USA.
EM waksman@cs.columbia.edu
FU AFOSR [FA 99500910389]; DARPA [FA 865011C7190, FA 87501020253]; NSF
[CCF/TC 1054844]
FX This work was supported by Grants FA 99500910389 (AFOSR), FA 865011C7190
(DARPA), FA 87501020253 (DARPA), CCF/TC 1054844 (NSF), and gifts from
Microsoft Research, WindRiver Corp, Xilinx, and Synopsys, Inc. Opinions,
findings, conclusions, and recommendations expressed in this material
are those of the authors and do not necessarily refect the views of the
U.S. Government or commercial entities.
NR 8
TC 4
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U1 0
U2 0
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 2168-2356
J9 IEEE DES TEST
JI IEEE Des. Test
PD MAR-APR
PY 2013
VL 30
IS 2
SI SI
BP 8
EP 16
DI 10.1109/MDT.2013.2247458
PG 9
WC Computer Science, Hardware & Architecture; Engineering, Electrical &
Electronic
SC Computer Science; Engineering
GA 232MK
UT WOS:000325497800003
ER
PT J
AU Karl, JP
Young, AJ
Rood, JC
Montain, SJ
AF Karl, J. Philip
Young, Andrew J.
Rood, Jennifer C.
Montain, Scott J.
TI Independent and Combined Effects of Eating Rate and Energy Density on
Energy Intake, Appetite, and Gut Hormones
SO OBESITY
LA English
DT Article
ID GLUCAGON-LIKE PEPTIDE-1; FOOD-INTAKE; PANCREATIC-POLYPEPTIDE; PLASMA
GHRELIN; OBESE SUBJECTS; WEIGHT STATUS; FAT-CONTENT; SATIETY; WOMEN;
HUMANS
AB Objective: Energy density (ED) and eating rate (ER) influence energy intake; their combined effects on intake and on postprandial pancreatic and gut hormone responses are undetermined. To determine the combined effects of ED and ER manipulation on voluntary food intake, subjective appetite, and postprandial pancreatic and gut hormone responses.
Design and Methods: Twenty nonobese volunteers each consumed high (1.6 kcal g(-1); HED) and low (1.2 kcal g(-1); LED) ED breakfasts slowly (20 g min(-1); SR) and quickly (80 g min(-1); FR) ad libitum to satiation. Appetite, and pancreatic and gut hormone concentrations were measured periodically over 3 h. Ad libitum energy intake during the subsequent lunch was then measured.
Results: Main effects of ED and ER on energy intake and a main effect of ER, but not ED, on mass of food consumed were observed, FR and HED being associated with increased intake (P < 0.05). Across all conditions, energy intake was highest during FR-HED (P <= 0.01). Area under the curve (AUC) of appetite ratings was not different between meals. Main effects of ED and ER on insulin, peptide-YY, and glucagon-like peptide-1 AUC (P < 0.05) were observed, FR and HED being associated with larger AUC. No effects on active or total ghrelin AUC were documented. Total energy intake over both meals was highest during the FR-HED trial with the greatest difference between FR-HED and SR-LED trials (P <= 0.01).
Conclusion: Consuming an energy dense meal quickly compounds independent effects of ER and ED on energy intake. Energy compensation at the following meal may not occur despite altered gut hormone responses.
C1 [Karl, J. Philip; Young, Andrew J.; Montain, Scott J.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA USA.
[Rood, Jennifer C.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Clin Chem Core, Baton Rouge, LA USA.
RP Karl, JP (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA USA.
EM james.p.karl@us.army.mil
OI Karl, J. Philip/0000-0002-5871-2241
FU US Army Medical Research and Materiel Command
FX Funding agencies: This study is funded by the US Army Medical Research
and Materiel Command.
NR 40
TC 12
Z9 12
U1 6
U2 21
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD MAR
PY 2013
VL 21
IS 3
BP E244
EP E252
DI 10.1002/oby.20075
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 187AK
UT WOS:000322087600010
PM 23592679
ER
PT J
AU Zander, NE
AF Zander, Nicole E.
TI Hierarchically Structured Electrospun Fibers
SO POLYMERS
LA English
DT Review
DE electrospinning; hierarchical; core-shell; helical; nanoporous;
patterned; nanofiber
ID UNIAXIALLY ALIGNED ARRAYS; ELECTRICALLY FORCED JETS; BLOCK-COPOLYMER
FIBERS; POLYMER NANOFIBERS; CELLULAR INFILTRATION; CARBON NANOFIBERS;
EXHIBITING SUPERHYDROPHOBICITY; COMPOSITE NANOFIBERS; COLLAGEN
NANOFIBERS; CONJUGATED POLYMERS
AB Traditional electrospun nanofibers have a myriad of applications ranging from scaffolds for tissue engineering to components of biosensors and energy harvesting devices. The generally smooth one-dimensional structure of the fibers has stood as a limitation to several interesting novel applications. Control of fiber diameter, porosity and collector geometry will be briefly discussed, as will more traditional methods for controlling fiber morphology and fiber mat architecture. The remainder of the review will focus on new techniques to prepare hierarchically structured fibers. Fibers with hierarchical primary structures-including helical, buckled, and beads-on-a-string fibers, as well as fibers with secondary structures, such as nanopores, nanopillars, nanorods, and internally structured fibers and their applications-will be discussed. These new materials with helical/buckled morphology are expected to possess unique optical and mechanical properties with possible applications for negative refractive index materials, highly stretchable/high-tensile-strength materials, and components in microelectromechanical devices. Core-shell type fibers enable a much wider variety of materials to be electrospun and are expected to be widely applied in the sensing, drug delivery/controlled release fields, and in the encapsulation of live cells for biological applications. Materials with a hierarchical secondary structure are expected to provide new superhydrophobic and self-cleaning materials.
C1 US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Zander, NE (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM nicole.e.zander.civ@mail.mil
NR 191
TC 23
Z9 23
U1 35
U2 377
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2073-4360
J9 POLYMERS-BASEL
JI Polymers
PD MAR
PY 2013
VL 5
IS 1
BP 19
EP 44
DI 10.3390/polym5010019
PG 26
WC Polymer Science
SC Polymer Science
GA 185DO
UT WOS:000321945600002
ER
PT J
AU Suir, GM
Evers, DE
Steyer, GD
Sasser, CE
AF Suir, Glenn M.
Evers, D. Elaine
Steyer, Gregory D.
Sasser, Charles E.
TI Development of a Reproducible Method for Determining Quantity of Water
and its Configuration in a Marsh Landscape
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article
DE Landscape characterization; fragmentation metrics; landscape pattern
analysis; wetlands; coastal Louisiana; geospatial technologies
ID METRICS; SCALE; PATTERN
AB Coastal Louisiana is a dynamic and ever-changing landscape. From 1956 to 2010, over 3,734 km(2) of Louisiana's coastal wetlands have been lost due to a combination of natural and human-induced activities. The resulting landscape constitutes a mosaic of conditions from highly deteriorated to relatively stable with intact landmasses. Understanding how and why coastal landscapes change over time is critical to restoration and rehabilitation efforts. Historically, changes in marsh pattern (i.e., size and spatial distribution of marsh landmasses and water bodies) have been distinguished using visual identification by individual researchers. Difficulties associated with this approach include subjective interpretation, uncertain reproducibility, and laborious techniques. In order to minimize these limitations, this study aims to expand existing tools and techniques via a computer-based method, which uses geospatial technologies for determining shifts in landscape patterns. Our method is based on a raster framework and uses landscape statistics to develop conditions and thresholds for a marsh classification scheme. The classification scheme incorporates land and water classified imagery and a two-part classification system: (1) ratio of water to land, and (2) configuration and connectivity of water within wetland landscapes to evaluate changes in marsh patterns. This analysis system can also be used to trace trajectories in landscape patterns through space and time. Overall, our method provides a more automated means of quantifying landscape patterns and may serve as a reliable landscape evaluation tool for future investigations of wetland ecosystem processes in the northern Gulf of Mexico.
C1 [Suir, Glenn M.] Louisiana State Univ, US Army, Engineer Res & Dev Ctr, Baton Rouge, LA 70803 USA.
[Evers, D. Elaine; Sasser, Charles E.] Louisiana State Univ, Sch Coast & Environm, Coastal Ecol Inst, Baton Rouge, LA 70803 USA.
[Steyer, Gregory D.] Louisiana State Univ, US Geol Survey, Natl Wetlands Res Ctr, Livestock Show Off, Baton Rouge, LA 70894 USA.
RP Suir, GM (reprint author), Louisiana State Univ, US Army, Engineer Res & Dev Ctr, 3253 Energy Coast & Environm Bldg, Baton Rouge, LA 70803 USA.
EM Glenn.M.Suir@usace.army.mil
FU U.S. Department of Interior, Bureau of Ocean Energy Management,
Regulation and Enforcement, Gulf of Mexico Region, Gulf of Mexico Outer
Continental Shelf Region
FX This research was supported in part by the U.S. Department of Interior,
Bureau of Ocean Energy Management, Regulation and Enforcement, Gulf of
Mexico Region (Formerly Mineral Management Service, Gulf of Mexico Outer
Continental Shelf Region) Gulf of Mexico Outer Continental Shelf Region.
We are grateful to our colleagues Craig Conzelmann and William Sleavin
for provision of data processing and transformation applications. Any
use of trade, product, or firm names is for descriptive purposes only
and does not imply endorsement by the U.S. Government.
NR 28
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U2 12
PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
J9 J COASTAL RES
JI J. Coast. Res.
PD SPR
PY 2013
SI 63
BP 110
EP 117
DI 10.2112/SI63-010.1
PG 8
WC Environmental Sciences; Geography, Physical; Geosciences,
Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA 173KE
UT WOS:000321077600010
ER
PT J
AU Morang, A
Rosati, JD
King, DB
AF Morang, Andrew
Rosati, Julie D.
King, David B.
TI Regional Sediment Processes, Sediment Supply, and Their Impact on the
Louisiana Coast
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article
DE Mississippi River; Atchafalaya River; sediment budget; delta;
distributary; barrier island; Balize Delta; dredging
ID GULF-OF-MEXICO; MISSISSIPPI DELTA PLAIN; BARRIER-ISLAND ARC; RIVER
DELTA; ISLES-DERNIERES; INNER SHELF; USA; RESTORATION; TRANSPORT;
HURRICANES
AB Coastal Louisiana is geologically unique in the United States because its complex shallow geologic structure is the result of fluvial deposition (Mississippi and Atchafalaya Rivers) and marine reworking over thousands of years. Other characteristics include the preponderance of fine sediment, relative youth, and shallow nearshore slope. It has been impacted by more than 150 years of project-focused designs that have modified regional sediment transport. Because of engineering and commercial activities on the upper Mississippi River and the delta, the system is now suffering from innumerable geomorphic changes, which have produced profound social and economic consequences. Sediment to this coast has been almost totally supplied by the Mississippi's distributaries, with deltaic lobes changing over the centuries. Sediment delivery has diminished by over 50% during the last 150 years because of up-river engineering activities such as dam construction, bank stabilization, dredging, and levees. The ultimate implication of reduced sediment and rapid relative sea-level rise is that the delta can no longer grow as it did before urbanization and development of the continent. A sediment budget has been developed for the Louisiana coast based on multiyear data preceding Hurricanes Katrina and Rita. The budget is based on numerous sources and dredging data from the U.S. Army Corps of Engineers, New Orleans District. Despite the typically low-wave energy climate, sediment is transported alongshore between some cells. Also, there is significant loss offshore, possibly a consequence of storm impacts, sediment consolidation, and rapid relative sea-level rise.
C1 [Morang, Andrew; Rosati, Julie D.; King, David B.] US Army, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA.
RP Morang, A (reprint author), US Army, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM Andrew.Morang@usace.army.mil
FU USACE, New Orleans District; LACPR Program; National Shoreline
Management Study; RSM Program
FX The authors thank Drs. Edmond Russo and Jeffrey Waters and two anonymous
reviewers for insightful comments. Numerous personnel at USACE, New
Orleans and Galveston Districts, generously supplied dredging,
topographic, and other data. Mckenzie Pollock assisted with editorial
reviewing. This work was funded by USACE, New Orleans District, the
LACPR Program, the National Shoreline Management Study, and the RSM
Program. Permission was granted by the Chief of Engineers to publish
this information. Any use of trade names or products is for descriptive
purposes and does not imply endorsement by the U.S. Government.
NR 125
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U2 38
PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
J9 J COASTAL RES
JI J. Coast. Res.
PD SPR
PY 2013
SI 63
BP 141
EP 165
DI 10.2112/SI63-013.1
PG 25
WC Environmental Sciences; Geography, Physical; Geosciences,
Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA 173KE
UT WOS:000321077600013
ER
PT J
AU Byrnes, MR
Rosati, JD
Griffee, SF
Berlinghoff, JL
AF Byrnes, Mark R.
Rosati, Julie D.
Griffee, Sarah F.
Berlinghoff, Jennifer L.
TI Historical Sediment Transport Pathways and Quantities for Determining an
Operational Sediment Budget: Mississippi Sound Barrier Islands
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article
DE Bathymetric change; shoreline change; Ship Island; Horn Island; Petit
Bois Island; channel dredging
ID GULF-OF-MEXICO; CHAIN; USA; EVOLUTION; ALABAMA
AB Historical shoreline and bathymetric survey data were compiled for the barrier islands and passes fronting Mississippi Sound to identify net littoral sand transport pathways, quantify the magnitude of net sand transport, and develop an operational sediment budget spanning a 90-year period. Net littoral sand transport along the islands and passes is primarily unidirectional (east-to-west). Beach erosion along the east side of each island and sand spit deposition to the west result in an average sand flux of about 400,000 cy/yr (305,000 m(3)/yr) throughout the barrier island system. Dog Keys Pass, located updrift of East Ship Island, is the only inlet acting as a net sediment sink. It also is the widest pass in the system (about 10 km) and has two active channels and ebb shoals. As such, a deficit of sand exists along East Ship Island. Littoral sand transport decreases rapidly along West Ship Island, where exchange of sand between islands terminates because of wave sheltering from the Chandeleur Islands and shoals at the eastern margin of the St. Bernard delta complex, Louisiana. These data were used to assist with design of a large island restoration project along Ship Island; Mississippi.
C1 [Byrnes, Mark R.; Griffee, Sarah F.; Berlinghoff, Jennifer L.] Appl Coastal Res & Engn, Mashpee, MA 02649 USA.
[Rosati, Julie D.] US Army, Engn Res & Dev Ctr, Coastal & Hydraul Lab, Coastal Inlets Res Program, Vicksburg, MS 39180 USA.
RP Byrnes, MR (reprint author), Appl Coastal Res & Engn, 766 Falmouth Rd Suite A-1, Mashpee, MA 02649 USA.
EM mbyrnes@appliedcoastal.com
FU USACE, Mobile District, Mississippi Coastal Improvements Program (MsCIP)
FX The USACE, Mobile District, Mississippi Coastal Improvements Program
(MsCIP) funded this project. Authors are grateful for assistance
provided by Ms. Susan I. Rees (MsCIP Program Director), Ms. Elizabeth
Godsey (USACE), Mr. John Baehr (USACE), Mr. Jason Krick (USACE), Mr.
Justin McDonald (USACE), Mr. David Twichell (USGS), Mr. Jeff Williams
(USGS), Mr. Jim Woods (National Park Service; NPS), Ms. Rebecca Beavers
(NPS), Ms. Linda York (NPS), Mr. Bruce McCraney (NPS), and Mr. Rick
Clark (National Park Service; (NPS). Special thanks to two anonymous
peer reviewers, whose comments greatly improved the clarity of this
manuscript.
NR 45
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U2 13
PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
J9 J COASTAL RES
JI J. Coast. Res.
PD SPR
PY 2013
SI 63
BP 166
EP 183
DI 10.2112/SI63-014.1
PG 18
WC Environmental Sciences; Geography, Physical; Geosciences,
Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA 173KE
UT WOS:000321077600014
ER
PT J
AU Ahn, J
Yang, CT
Boyd, PM
Pridal, DB
Remus, JI
AF Ahn, Jungkyu
Yang, Chih Ted
Boyd, Paul M.
Pridal, Daniel B.
Remus, John I.
TI Numerical modeling of sediment flushing from Lewis and Clark Lake
SO INTERNATIONAL JOURNAL OF SEDIMENT RESEARCH
LA English
DT Article
DE Drawdown flushing; Flushing efficiency; GSTARS computer model; Reservoir
sedimentation; Sediment transport; Lewis and Clark Lake
ID RESERVOIR SEDIMENTATION
AB Lewis and Clark Lake is located on the main stream of the Missouri River. The reservoir is formed behind Gavins Point dam near Yankton, South Dakota, U. S. A. The Lewis and Clark Lake reach extends about 40 km from the Gavins Point dam. The reservoir delta has been growing since the closure of Gavins Point dam in 1955 and has resulted in a 21% reduction of storage within the maximum pool of the reservoir. Among several sediment management methods, drawdown flushing has been recommended as a possible management technique. The engineering viability of removing sediments deposited in the lake should be examined by numerical modeling before implementing a drawdown flushing. GSTARS4 was used for this study and calibrated by using measured data from 1975 to 1995. Channel cross-section changes and amount of flushed sediment were predicted with four hypothetical flow scenarios. The flushing efficiencies of all scenarios were estimated by comparing the ratios between water consumption and flushed sediment during flushing.
C1 [Ahn, Jungkyu] Seoul Natl Univ, Dept Civil & Environm Engn, Seoul, South Korea.
[Yang, Chih Ted] Colorado State Univ, Dept Civil & Environm Engn, Hydrosci & Training Ctr, Ft Collins, CO 80526 USA.
[Boyd, Paul M.] US Army Corps Engineers, Omaha, NE USA.
[Pridal, Daniel B.] US Army Corps Engineers, Sedimentat & Channel Stabilizat Sect, Omaha, NE USA.
[Remus, John I.] Hydrol Engn Branch, Omaha, NE USA.
RP Ahn, J (reprint author), Seoul Natl Univ, Dept Civil & Environm Engn, Seoul, South Korea.
EM ajk38317@naver.com; ctyang@engr.colostate.edu
NR 15
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U1 0
U2 6
PU IRTCES
PI BEIJING
PA PO BOX 366, BEIJING, 100044, PEOPLES R CHINA
SN 1001-6279
J9 INT J SEDIMENT RES
JI Int. J. Sediment Res.
PD MAR
PY 2013
VL 28
IS 2
BP 182
EP 193
PG 12
WC Environmental Sciences; Water Resources
SC Environmental Sciences & Ecology; Water Resources
GA 174IA
UT WOS:000321147500006
ER
PT J
AU Maruta, J
Heaton, KJ
Kryskow, EM
Maule, AL
Ghajar, J
AF Maruta, Jun
Heaton, Kristin J.
Kryskow, Elisabeth M.
Maule, Alexis L.
Ghajar, Jamshid
TI Dynamic visuomotor synchronization: Quantification of predictive timing
SO BEHAVIOR RESEARCH METHODS
LA English
DT Article
DE Attention; Smooth pursuit; Test-retest reliability; Concussion;
Traumatic brain injury
ID PURSUIT EYE-MOVEMENTS; TRAUMATIC BRAIN-INJURY; SMOOTH-PURSUIT;
PARKINSONS-DISEASE; COGNITIVE CONTROL; CEREBRAL CONTROL; TARGET MOTIONS;
ATTENTION; TRACKING; DEFICITS
AB When a moving target is tracked visually, spatial and temporal predictions are used to circumvent the neural delay required for the visuomotor processing. In particular, the internally generated predictions must be synchronized with the external stimulus during continuous tracking. We examined the utility of a circular visual-tracking paradigm for assessment of predictive timing, using normal human subjects. Disruptions of gaze-target synchronization were associated with anticipatory saccades that caused the gaze to be temporarily ahead of the target along the circular trajectory. These anticipatory saccades indicated preserved spatial prediction but suggested impaired predictive timing. We quantified gaze-target synchronization with several indices, whose distributions across subjects were such that instances of extremely poor performance were identifiable outside the margin of error determined by test-retest measures. Because predictive timing is an important element of attention functioning, the visual-tracking paradigm and dynamic synchronization indices described here may be useful for attention assessment.
C1 [Maruta, Jun; Ghajar, Jamshid] Brain Trauma Fdn, New York, NY 10007 USA.
[Heaton, Kristin J.; Kryskow, Elisabeth M.; Maule, Alexis L.] USA, Environm Med Res Inst, Natick, MA 01760 USA.
[Heaton, Kristin J.; Maule, Alexis L.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA.
[Ghajar, Jamshid] Weill Cornell Med Coll, Dept Neurol Surg, New York, NY USA.
RP Maruta, J (reprint author), Brain Trauma Fdn, 7 World Trade Ctr,34th Floor,250 Greenwich St, New York, NY 10007 USA.
EM jmaruta@braintrauma.org
RI Heaton, Kristin/E-3660-2013;
OI Maruta, Jun/0000-0002-5054-6605
NR 55
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U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1554-351X
J9 BEHAV RES METHODS
JI Behav. Res. Methods
PD MAR
PY 2013
VL 45
IS 1
BP 289
EP 300
DI 10.3758/s13428-012-0248-3
PG 12
WC Psychology, Mathematical; Psychology, Experimental
SC Psychology
GA 156DK
UT WOS:000319800900027
PM 22956395
ER
PT J
AU Abadie, JM
AF Abadie, Jude M.
TI How Can a Methadone and an Opiate-Positive Immunoassay Result be
Reconciled in a Patient Prescribed only OxyContin and Wellbutrin?
SO ANNALS OF CLINICAL AND LABORATORY SCIENCE
LA English
DT Article
DE Urine Drug Testing; Pain management; methadone; oxycodone
ID TOXICOLOGY
AB Appropriate management of patients in pain clinics can be complex and sometimes confusing because providers must correctly interpret multiple sources of patient information. The correct interpretation of laboratory results is essential to guide subsequent patient treatment and management; however, laboratory and clinical pictures can appear to be conflicting in cases of substance abuse. Incorrect interpretation of laboratory results can multiply negative impacts on clinical outcomes and may lead to patient harm or death.
This report introduces the complex nature involved in understanding and interpreting urine drug testing (UDT) results in pain patients who are prescribed opioid medications. Laboratory testing examples of UDT results are,provided to illustrate the sometimes discordant nature of UDT interpretation. This case study describes one method of approaching cases where laboratory result interpretation in pain clinic patients is essential for medical treatment and management. The case presented in this manuscript illustrates a reconciliation of an opiate positive immunoassay result in a patient who was prescribed only OxyContin and Wellbutrin after traumatic amputations.
C1 [Abadie, Jude M.] Tripler Army Med Ctr, Dept Pathol, Honolulu, HI 96859 USA.
RP Abadie, JM (reprint author), Point Care Testing Tripler Army Med Ctr, Out Patient Lab, Core Lab, Dept Pathol, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM jude.abadie@amedd.army.mil
NR 15
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U1 0
U2 2
PU ASSOC CLINICAL SCIENTISTS
PI MIDDLEBURY
PA PO BOX 1287, MIDDLEBURY, VT 05753 USA
SN 0091-7370
J9 ANN CLIN LAB SCI
JI Ann. Clin. Lab. Sci.
PD SPR
PY 2013
VL 43
IS 2
BP 190
EP 194
PG 5
WC Medical Laboratory Technology
SC Medical Laboratory Technology
GA 146PO
UT WOS:000319103200013
PM 23694796
ER
PT J
AU Houpt, JT
Leach, GJ
Williams, LR
Johnson, MS
Reddy, G
AF Houpt, John T.
Leach, Glenn J.
Williams, Larry R.
Johnson, Mark S.
Reddy, Gunda
TI Toxicity Assessment of 4-Amino-2-Nitrotoluene
SO INTERNATIONAL JOURNAL OF TOXICOLOGY
LA English
DT Article
DE 4-amino-2-nitrotoluene; CAS 119-32-4; oral toxicity; benchmark dose; RfD
ID SUBCHRONIC TOXICITY; FISCHER-344 RATS; 2,4-DINITROTOLUENE;
1,3,5-TRINITROBENZENE; DINITROTOLUENE; RESTRICTION; TESTIS
AB 4-Amino-2-nitrotoluene (4A2NT; CAS 119-32-4) is a degradation product of 2,4-dinitrotoluene. The toxicity data on 4A2NT are limited. Therefore, we collected toxicity data from rats to assess environmental and human health effects from exposures. The approximate lethal dose for both sexes was 5000 mg/kg. A 14-day toxicity study in rats was conducted with 4A2NT in the feed at concentrations of 0, 125, 250, 500, 1000, and 2000 ppm. Based on a 14-day oral dose range toxicity study with 4A2NT in the feed, 2000 ppm was selected as highest concentration for a subsequent 90-day study. An oral 90-day subchronic toxicity study in rats was conducted with concentrations of 0, 500, 1000, or 2000 ppm of 4A2NT in the feed. The calculated consumed doses of 4A2NT in the feed were 0, 27, 52, or 115 mg/kg/d for males and 0, 32, 65, or 138 mg/kg/d for females. A no-observed adverse effect level could not be determined. The lowest observed adverse effect level was 27 mg/kg/d for males and 32 mg/kg/d for female rats based upon decreased body weight gain. The decreased body weight gain in male rats was the most sensitive adverse event observed in this study and was used to derive a benchmark dose (BMD). A BMD of 23.1 mg/kg/d and BMD with 10% effect level of 15.5 mg/kg/d were calculated for male rats, which were used to derive an oral reference dose (RfD). The human RfD of 1.26 mg/kg/d was derived using current United States Environmental Protection Agency guidelines.
C1 [Houpt, John T.; Leach, Glenn J.; Williams, Larry R.; Johnson, Mark S.] USA, Publ Hlth Command, Army Inst Publ Hlth, Aberdeen Proving Ground, MD 21010 USA.
[Reddy, Gunda] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA.
RP Reddy, G (reprint author), USA, Inst Publ Hlth, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
EM gunda.reddy@us.army.mil
FU Installation Management Command/Army Environmental Command, Fort Sam
Houston, Texas
FX The author(s) disclosed receipt of the following financial support for
the research, authorship, and/or publication of this article:
Installation Management Command/Army Environmental Command, Fort Sam
Houston, Texas.
NR 29
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U1 0
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1091-5818
J9 INT J TOXICOL
JI Int. J. Toxicol.
PD MAR-APR
PY 2013
VL 32
IS 2
BP 113
EP 122
DI 10.1177/1091581813480408
PG 10
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA 148EX
UT WOS:000319227000003
PM 23493902
ER
PT J
AU Rose, G
McChrystal, S
AF Rose, Gideon
McChrystal, Stanley
TI Generation Kill A Conversation With Stanley McChrystal
SO FOREIGN AFFAIRS
LA English
DT Editorial Material
C1 [McChrystal, Stanley] USA, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU COUNCIL FOREIGN RELAT IONS INC
PI NEW YORK
PA HAROLD PRATT HOUSE, 58 E 68TH ST, NEW YORK, NY 10065 USA
SN 0015-7120
J9 FOREIGN AFF
JI Foreign Aff.
PD MAR-APR
PY 2013
VL 92
IS 2
BP 2
EP +
PG 6
WC International Relations
SC International Relations
GA 145NO
UT WOS:000319023900001
ER
PT J
AU Knox, JB
Knox, JA
Wimberly, RL
Riccio, AI
AF Knox, Jeffrey Bruce
Knox, Jennifer Asarias
Wimberly, Robert Lane
Riccio, Anthony I.
TI Flexion-distraction Injuries in Children and Adolescents
SO ORTHOPEDICS
LA English
DT Review
ID SEAT-BELT INJURIES; PEDIATRIC CHANCE FRACTURES; SPINE; RESTRAINTS;
CRASHES
AB Flexion-distraction injuries represent an uncommon pattern of injury in the pediatric population. Although this is a well-studied topic in adults, the literature on such injuries in children and adolescents is relatively sparse, with only low levels of evidence available to guide treatment. These injuries carry a high rate of concomitant injuries and a high morbidity and mortality in this population. Proper understanding of these complex injuries is important to ensure proper management and avoid complications.
C1 [Knox, Jeffrey Bruce] Tripler Army Med Ctr, Orthoped Surg Serv, Honolulu, HI 96859 USA.
[Knox, Jennifer Asarias] Tripler Army Med Ctr, Gen Surg Serv, Honolulu, HI 96859 USA.
[Wimberly, Robert Lane; Riccio, Anthony I.] Texas Scottish Rite Hosp Children, Dallas, TX 75219 USA.
[Wimberly, Robert Lane; Riccio, Anthony I.] Childrens Med Ctr, Dallas, TX 75235 USA.
RP Knox, JB (reprint author), Tripler Army Med Ctr, Orthoped Surg Serv, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM jknox49@gmail.com
NR 30
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Z9 0
U1 0
U2 1
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0147-7447
J9 ORTHOPEDICS
JI Orthopedics
PD MAR
PY 2013
VL 36
IS 3
BP 214
EP 218
DI 10.3928/01477447-20130222-09
PG 5
WC Orthopedics
SC Orthopedics
GA 136EZ
UT WOS:000318346100033
PM 23464942
ER
PT J
AU Watson, JR
Siska, P
Wolfel, RL
AF Watson, Jeffrey R.
Siska, Peter
Wolfel, Richard L.
TI Assessing Gains in Language Proficiency, Cross-Cultural Competence, and
Regional Awareness During Study Abroad: A Preliminary Study
SO FOREIGN LANGUAGE ANNALS
LA English
DT Article
DE cross-cultural competence; internationalization; language proficiency;
regional awareness; study abroad outcomes assessment
ID CURRICULUM; STUDENTS
AB As a critical part of the internationalization movement in college curricula, study abroad initiatives are becoming more and more popular and the need to assess their outcomes more and more evident. While numerous studies have investigated the language gain associated with study abroad, researchers are also beginning to look at potential gains in the areas of cultural and regional competence. This study presents a theoretical background for a three-tiered model for assessing student outcomes during study abroad in three domainslanguage proficiency, cross-cultural competence, and regional awarenessand presents the quantitative data gathered from the implementation of this model. Results show the feasibility of assessing these outcomes in a holistic manner through formal assessment instruments and participant coaching pre- and post-immersion.
C1 [Watson, Jeffrey R.; Wolfel, Richard L.] US Mil Acad, West Point, NY 10996 USA.
[Siska, Peter] US Mil Acad, Ctr Languages Cultures & Reg Studies, West Point, NY 10996 USA.
RP Watson, JR (reprint author), US Mil Acad, West Point, NY 10996 USA.
OI Watson, Jeff/0000-0003-1948-6859
NR 46
TC 6
Z9 6
U1 0
U2 16
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0015-718X
J9 FOREIGN LANG ANN
JI Foreign Lang. Ann.
PD MAR
PY 2013
VL 46
IS 1
BP 62
EP 79
DI 10.1111/flan.12016
PG 18
WC Education & Educational Research; Linguistics
SC Education & Educational Research; Linguistics
GA 134SR
UT WOS:000318235300006
ER
PT J
AU Sanamyan, T
Pavlacka, R
Gilde, G
Dubinskii, M
AF Sanamyan, T.
Pavlacka, R.
Gilde, G.
Dubinskii, M.
TI Spectroscopic properties of Er3+-doped alpha-Al2O3
SO OPTICAL MATERIALS
LA English
DT Article
ID LASERS; SAPPHIRE; CORUNDUM; ER3+
AB We present the results of comprehensive spectroscopic study of the recently successfully synthesized nanopowders and fully densified transparent ceramics of Er3+-doped alpha-Al2O3 (corundum). Fluorescence and excitation spectra in a range of temperatures of 10-300 K were used to infer the energy level schemes of the ground state and the first three excited Er3+ multiplets (I-4(15/2), I-4(13/2), I-4(11/2), and I-4(9/2)) in this material. Obtained experimental data also allowed us to assess this material as a potential gain medium for high power laser applications in anticipation that it becomes available in the low-loss grain-aligned ceramic or single crystalline form in the near future. Published by Elsevier B.V.
C1 [Sanamyan, T.; Dubinskii, M.] USA, Res Lab, RDRL SEE M, Adelphi, MD 20783 USA.
[Pavlacka, R.; Gilde, G.] USA, Res Lab, RDRL WMM E, Aberdeen Proving Ground, MD 21005 USA.
RP Sanamyan, T (reprint author), USA, Res Lab, RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM tigran.sanamyan@us.army.mil
FU High Energy Laser Joint Technology Office
FX The authors gratefully acknowledge financial support of this work by the
High Energy Laser Joint Technology Office. The authors also thank T.
Parker and J. Demaree of U.S. Army Research Laboratory for their
assistance in conducting and interpreting the RBS results.
NR 23
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U1 4
U2 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0925-3467
J9 OPT MATER
JI Opt. Mater.
PD MAR
PY 2013
VL 35
IS 5
BP 821
EP 826
DI 10.1016/j.optmat.2012.10.036
PG 6
WC Materials Science, Multidisciplinary; Optics
SC Materials Science; Optics
GA 128WQ
UT WOS:000317800800001
ER
PT J
AU Schafer, JL
Breslow, BP
Just, MG
Hohmann, MG
Hollingsworth, SN
Swatling-Holcomb, SL
Hoffmann, WA
AF Schafer, Jennifer L.
Breslow, Bradley P.
Just, Michael G.
Hohmann, Matthew G.
Hollingsworth, Stephanie N.
Swatling-Holcomb, Samantha L.
Hoffmann, William A.
TI Current and Historical Variation in Wiregrass (Aristida stricta)
Abundance and Distribution Is Not Detectable from Soil delta C-13
Measurements in Longleaf Pine (Pinus palustris) Savannas
SO CASTANEA
LA English
DT Article
DE Carbon; depth profiles; ecotone; pocosin; species distributions
ID SOUTHEASTERN UNITED-STATES; PAST VEGETATION CHANGES; ORGANIC-MATTER;
CARBON ISOTOPES; NORTH-CAROLINA; ECOSYSTEM; FIRE; PRODUCTIVITY; CLIMATE;
FOREST
AB Plant species distributions and transitions between vegetation types are determined by numerous factors, including disturbances such as fire. Documentation of past changes in the distribution and structure of fire-dependent ecosystems is necessary to assess the success of land management in maintaining historic vegetation types. In our study system-longleaf pine (Pinus palustris)-wiregrass (Aristida stricta) savannas and embedded wetlands (i.e., pocosins)-wiregrass is dependent on frequent burning. We used soil carbon (C) isotopes to test for past changes in the abundance of wiregrass and for shifts in the ecotone between savanna and pocosin in four sites at Fort Bragg, North Carolina. Wiregrass has a C-4 photosynthetic pathway and therefore produces organic matter enriched in C-13 compared to other dominant species in the community that have a C-3 photosynthetic pathway. At each of the four sites, we measured profiles of soil delta C-13 to a depth of 1 m at four locations along the vegetation gradient from upland savannas to lowland pocosins. Surface soil delta C-13, which reflects C inputs from current vegetation, did not differ along the gradient despite a decrease in wiregrass cover from savanna, where it is abundant, to pocosin, where it is absent. Enrichment of soil delta C-13 with depth was indistinguishable from effects of decomposition, indicating that past variation in the abundance and distribution of wiregrass was not detectable in our study sites. Our results suggest that wiregrass currently does not produce, and historically has not produced, enough biomass to influence soil delta C-13 values along the savanna-pocosin gradient.
C1 [Schafer, Jennifer L.; Breslow, Bradley P.; Just, Michael G.; Hollingsworth, Stephanie N.; Swatling-Holcomb, Samantha L.; Hoffmann, William A.] N Carolina State Univ, Dept Plant Biol, Raleigh, NC 27695 USA.
[Hohmann, Matthew G.] US Army Corps Engineers, Engineer Res & Dev Ctr, Champaign, IL 61826 USA.
RP Schafer, JL (reprint author), N Carolina State Univ, Dept Plant Biol, 2115 Gardner Hall,Box 7612, Raleigh, NC 27695 USA.
EM jlschafe@ncsu.edu
OI Just, Michael/0000-0003-2493-9269
FU US Army Engineer Research and Development Center [W9132T-11-2-007]
FX We thank Janet B. Gray for logistical support. This research was
supported by a grant (W9132T-11-2-007) from the US Army Engineer
Research and Development Center to W. Hoffmann.
NR 46
TC 2
Z9 2
U1 1
U2 62
PU SOUTHERN APPALACHIAN BOTANICAL SOC, NEWBERRY COLL
PI NEWBERRY
PA DEPT BIOLOGY, C/O CHARLES N HORN, SECRETARY-TREASURER, 2100 COLLEGE ST,
NEWBERRY, SC 29108 USA
SN 0008-7475
EI 1938-4386
J9 CASTANEA
JI Castanea
PD MAR
PY 2013
VL 78
IS 1
BP 28
EP 36
DI 10.2179/12-021
PG 9
WC Plant Sciences
SC Plant Sciences
GA 124EF
UT WOS:000317445900004
ER
PT J
AU Hill, AA
Wong, L
Gerras, SJ
AF Hill, Andrew A.
Wong, Leonard
Gerras, Stephen J.
TI "Self-Interest Well Understood": The Origins & Lessons of Public
Confidence in the Military
SO DAEDALUS
LA English
DT Article
AB In recent decades, the U.S. military has enjoyed high levels of public confidence. We argue that the rise (and sustainment) of public confidence in the military reflects two phenomena. First, the public has a high regard for the military and its mission, arising from a shift to a professional (nonconscript) force that is perceived to be competent, fair, and accountable. Second, the public has little fear of military abuses in the domestic arena, owing chiefly to the reduced domestic presence of the military in the post-World War II era, with less emphasis on the physical defense of the homeland; and to the military's careful cultivation of an apolitical culture since Vietnam. We conclude with a brief discussion of the military's efforts to develop and encourage public-mindedness among its members, and the challenges to replicating the military approach in other institutional settings.
C1 [Hill, Andrew A.; Gerras, Stephen J.] USA, War Coll, Dept Command Leadership & Management, Washington, DC 20310 USA.
[Wong, Leonard] USA, War Coll, Strateg Studies Inst, Washington, DC USA.
[Wong, Leonard; Gerras, Stephen J.] USA, Washington, DC USA.
RP Hill, AA (reprint author), USA, War Coll, Dept Command Leadership & Management, Washington, DC 20310 USA.
NR 13
TC 1
Z9 1
U1 0
U2 0
PU MIT PRESS
PI CAMBRIDGE
PA 55 HAYWARD STREET, CAMBRIDGE, MA 02142 USA
SN 0011-5266
J9 DAEDALUS-US
JI Daedalus
PD SPR
PY 2013
VL 142
IS 2
BP 49
EP 64
PG 16
WC Humanities, Multidisciplinary; Social Sciences, Interdisciplinary
SC Arts & Humanities - Other Topics; Social Sciences - Other Topics
GA 124GU
UT WOS:000317452600007
ER
PT J
AU Center, TD
Parys, K
Grodowitz, M
Wheeler, GS
Dray, FA
O'Brien, CW
Johnson, S
Cofrancesco, A
AF Center, Ted D.
Parys, Katherine
Grodowitz, Mike
Wheeler, Gregory S.
Dray, F. Allen
O'Brien, Charles W.
Johnson, Seth
Cofrancesco, Al
TI EVIDENCE OF ESTABLISHMENT OF BAGOUS HYDRILLAE (COLEOPTERA:
CURCULIONIDAE), A BIOLOGICAL CONTROL AGENT OF HYDRILLA VERTICILLATA
(HYDROCHARITALES: HYDROCHARITACEAE) IN NORTH AMERICA?
SO FLORIDA ENTOMOLOGIST
LA English
DT Article
DE aquatic weeds; Bagous restrictus; biocontrol agent release; biocontrol
agent establishment; herbivory; phytophagous insects
ID AQUATIC WEED; AUSTRALIA; LEPIDOPTERA; PYRALIDAE; EVOLUTION; INSECTS;
RELEASE
AB The semi-aquatic weevil Bagous hydrillae was released during 1991-1996 at 19 sites in 4 states in attempts to control the aquatic weed hydrilla, Hydrilla verticillata. Fourteen of the sites were in Florida, 2 each in Texas and Georgia and one site in Alabama. Over 320,000 adult weevils were included in these releases. Despite the fact that a few adults were recovered as late as 4.5 yr post-release, presence of permanent, self-perpetuating populations was never confirmed. Then, during 2009 adult B. hydrillae were collected in southern Louisiana, at least 580 km from the nearest release site and 13 yr after attempts to establish this insect had terminated. This suggests that earlier recoveries were indicative of successful establishment and that this weevil species has persisted and dispersed widely in the southeastern USA. Nonetheless, there is no evidence that B. hydrillae has had a suppressive effect on hydrilla.
C1 [Center, Ted D.; Wheeler, Gregory S.; Dray, F. Allen] USDA ARS, Invas Plant Res Lab, Ft Lauderdale, FL 33314 USA.
[Parys, Katherine; Johnson, Seth] Louisiana State Univ, Ctr Agr, Dept Entomol, Louisiana Agr Expt Stn, Baton Rouge, LA 70803 USA.
[Grodowitz, Mike; Cofrancesco, Al] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[O'Brien, Charles W.] Univ Arizona, Dept Entomol, Tucson, AZ 85721 USA.
RP Center, TD (reprint author), USDA ARS, Invas Plant Res Lab, 3225 Coll Ave, Ft Lauderdale, FL 33314 USA.
EM Ted.Center@ars.usda.gov
OI Parys, Katherine/0000-0001-7459-3687
FU LSU AgCenter; Louisiana State Department of Wildlife and Fisheries;
Florida Department of Environmental Protection; US Army Corps of
Engineers; Southwest Florida Water Management District; USDA/ARS
FX A. Bishop, L. Bishop, W. C. Durden, L. Kasarjian, and B. Maharajh,
USDA-ARS, Invasive Plant Research Laboratory, assisted in the rearing,
release, and followup field work during the early years. Thanks to J.
Fryoux and A. Meszaros for field assistance in Louisiana. We also thank
R. S. Anderson, Canadian Museum of Nature, Ottawa, Ontario, Canada for
confirmation of weevil identifications, J. Boyce for access to his
property, and LSU AgCenter and Louisiana State Department of Wildlife
and Fisheries for funding. The Florida Department of Environmental
Protection, US Army Corps of Engineers, Southwest Florida Water
Management District, and USDA/ARS provided funding for the initial
project and their support is greatly appreciated.
NR 30
TC 4
Z9 4
U1 0
U2 20
PU FLORIDA ENTOMOLOGICAL SOC
PI LUTZ
PA 16125 E LAKE BURRELL DR, LUTZ, FL 33548 USA
SN 0015-4040
J9 FLA ENTOMOL
JI Fla. Entomol.
PD MAR
PY 2013
VL 96
IS 1
BP 180
EP 186
PG 7
WC Entomology
SC Entomology
GA 123HO
UT WOS:000317379200024
ER
PT J
AU Sitaraman, J
Potsdam, M
Wissink, A
Jayaraman, B
Datta, A
Mavriplis, D
Saberi, H
AF Sitaraman, Jayanarayanan
Potsdam, Mark
Wissink, Andrew
Jayaraman, Buvaneswari
Datta, Anubhav
Mavriplis, Dimitri
Saberi, Hossein
TI Rotor Loads Prediction Using Helios: A Multisolver Framework for
Rotorcraft Aeromechanics Analysis
SO JOURNAL OF AIRCRAFT
LA English
DT Article; Proceedings Paper
CT 49th AIAA Aerospace Sciences Meeting/New Horizons Forum and Aerospace
Exposition
CY JAN 03-17, 2011
CL Orlando, FL
SP AIAA
AB This paper documents the prediction of UH-60A Black Hawk aerodynamic loading using the multisolver Computational Fluid Dynamics/Computational Structural Dynamics analysis framework for rotorcraft Helios for a range of critical steady forward flight conditions. Comparisons with available flight test data are provided for all of the predictions. The Helios framework combines multiple solvers and multiple grid paradigms (unstructured and adaptive Cartesian) such that the advantages of each paradigm is preserved. Further, the software is highly automated for execution and designed in a modular fashion to minimize the burden on both the users and developers. The technical approach presented herein provides details of all of the participant modules and the interfaces used for their integration into the software framework. The results composed of sectional aerodynamic loading and wake visualizations are presented. Solution-based adapative mesh refinement, a salient feature of the Helios framework, is explored for all flight conditions and comparisons are provided for both aerodynamic loading and vortex wake structure with and without adaptive mesh refinement.
C1 [Sitaraman, Jayanarayanan; Mavriplis, Dimitri] Univ Wyoming, Dept Mech Engn, Laramie, WY 82071 USA.
[Potsdam, Mark] USA, Aeroflightdynam Directorate, Res Dev & Engn Command, Moffett Field, CA 94035 USA.
[Wissink, Andrew] USA, Aeroflightdynam Directorate, Sci & Technol Corp, Moffett Field, CA 94035 USA.
[Jayaraman, Buvaneswari; Datta, Anubhav] NASA, Ames Res Ctr, Sci & Technol Corp, Moffett Field, CA 94035 USA.
[Saberi, Hossein] Adv Rotorcraft Technol Inc, Sunnyvale, CA 94085 USA.
RP Sitaraman, J (reprint author), Univ Wyoming, Dept Mech Engn, Laramie, WY 82071 USA.
EM saberi@flightlab.com
NR 26
TC 4
Z9 4
U1 0
U2 3
PU AMER INST AERONAUTICS ASTRONAUTICS
PI RESTON
PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA
SN 0021-8669
J9 J AIRCRAFT
JI J. Aircr.
PD MAR-APR
PY 2013
VL 50
IS 2
BP 478
EP 492
DI 10.2514/1.C031897
PG 15
WC Engineering, Aerospace
SC Engineering
GA 122MJ
UT WOS:000317321900015
ER
PT J
AU Yeo, H
AF Yeo, Hyeonsoo
TI Investigation of UH-60A Rotor Performance and Loads at High Advance
Ratios
SO JOURNAL OF AIRCRAFT
LA English
DT Article; Proceedings Paper
CT 68th Annual Forum of the American-Helicopter-Society
CY MAY 01-03, 2012
CL Fort Worth, TX
SP Amer Helicopter Soc
ID COMPREHENSIVE ANALYSIS; HELICOPTER ROTORS
AB Wind tunnel measurements of the performance, airloads, and structural loads of a full-scale UH-60A Black Hawk main rotor operating at high advance ratios (up to 1.0) are compared with calculations obtained using the comprehensive rotorcraft analysis Comprehensive Analytical Model of Rotorcraft Aerodynamics and Dynamics II to understand physics and quantify this comprehensive code's accuracy and reliability in the prediction of rotor performance and loads at high advance ratios. Detailed comparisons are made on rotor thrust, control angles, power, and section loads to illustrate and understand unique aeromechanics phenomena in this regime. The analysis correctly predicts the thrust reversal with collective at high advance ratios. Rotor induced plus profile power is also reasonably well predicted with proper modeling of the shank. Airloads and structural loads correlation is fair. A significant underprediction of 2-per-revolution structural loads is observed.
C1 USA, Aeroflightdynam Directorate AMRDEC, Ames Res Ctr, Res Dev & Engn Command, Moffett Field, CA 94035 USA.
RP Yeo, H (reprint author), USA, Aeroflightdynam Directorate AMRDEC, Ames Res Ctr, Res Dev & Engn Command, Moffett Field, CA 94035 USA.
EM hyeonsoo.yeo@us.army.mil
NR 31
TC 7
Z9 7
U1 0
U2 1
PU AMER INST AERONAUTICS ASTRONAUTICS
PI RESTON
PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA
SN 0021-8669
J9 J AIRCRAFT
JI J. Aircr.
PD MAR-APR
PY 2013
VL 50
IS 2
BP 576
EP 589
DI 10.2514/1.C031958
PG 14
WC Engineering, Aerospace
SC Engineering
GA 122MJ
UT WOS:000317321900023
ER
PT J
AU Gilman, S
AF Gilman, S.
TI Coulometric study of rates of oxalic acid adsorption at a
polycrystalline Platinum Electrode
SO JOURNAL OF ELECTROANALYTICAL CHEMISTRY
LA English
DT Article
DE Ion adsorption; Oxalic acid adsorption; Oxalic acid; Ethylene glycol
fuel cell; Fuel cell
ID SINGLE-CRYSTAL ELECTRODES; ETHYLENE-GLYCOL; TRACER METHODS; ANION
ADSORPTION; OXIDATION; BEHAVIOR; OXALATE
AB Quantitative measurement of adsorption/desorption of oxalic acid on a Pt electrode from a perchloric acid supporting electrolyte has been accomplished for the first time using a fast potential scan preceded by a sequence of potential steps. From a dilute solution of oxalic acid, adsorption as the oxalate/bioxylate anion is so rapid as to be diffusion-controlled over the range of potentials at which the surface is free of adsorbed oxygen; most of the final coverage achieved in less than a half-second. Cathodic desorption of the adsorbed anions occurs in the millisecond range. An isotherm for reversible adsorption applies to the range 0-0.9 V vs. a RHE but below 0.3 V, there is conversion to irreversible adsorption that is perceptible after hundreds of seconds. Irreversible adsorption as carbon monoxide blocks cathodic hydrogen underpotential deposition (upd) while adsorption as anions does not because the latter desorb at upd potentials. Adsorbed oxalic acid has a negative effect on the anodic oxidation of ethylene glycol and the reduction of molecular oxygen. (C) 2013 Elsevier B.V. All rights reserved.
C1 USA, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA.
RP Gilman, S (reprint author), USA, Sensors & Electron Devices Directorate, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM sol.gilman.civ@mail.mil
NR 26
TC 3
Z9 3
U1 1
U2 9
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 1572-6657
J9 J ELECTROANAL CHEM
JI J. Electroanal. Chem.
PD MAR 1
PY 2013
VL 692
BP 53
EP 59
DI 10.1016/j.jelechem.2013.01.013
PG 7
WC Chemistry, Analytical; Electrochemistry
SC Chemistry; Electrochemistry
GA 122ML
UT WOS:000317322100008
ER
PT J
AU Staab, JE
Beidleman, BA
Muza, SR
Fulco, CS
Rock, PB
Cymerman, A
AF Staab, Janet E.
Beidleman, Beth A.
Muza, Stephen R.
Fulco, Charles S.
Rock, Paul B.
Cymerman, Allen
TI Efficacy of Residence at Moderate Versus Low Altitude on Reducing Acute
Mountain Sickness in Men Following Rapid Ascent to 4300 m
SO HIGH ALTITUDE MEDICINE & BIOLOGY
LA English
DT Article
DE acute mountain sickness; hypobaric hypoxia; acclimatization; fluid
balance; ventilatory response to hypoxia
ID CARBOHYDRATE SUPPLEMENTATION; HYPOBARIC HYPOXIA; HEMOGLOBIN MASS;
EXERCISE; ACCLIMATIZATION; QUESTIONNAIRE; PERFORMANCE; SYMPTOMS;
NATIVES; BALANCE
AB Staab, Janet E., Beth A. Beidleman, Stephen R. Muza, Charles S. Fulco, Paul B. Rock, and Allen Cymerman. Efficacy of residence at moderate versus low altitude on reducing acute mountain sickness in men following rapid ascent to 4300 m. High Alt Med Biol 14:13-18, 2013.-To determine if residence at moderate (similar to 2000 m) compared to low (<50 m) altitude reduces acute mountain sickness (AMS) in men during subsequent rapid ascent to a higher altitude. Nine moderate-altitude residents (MAR) and 18 sea-level residents (SLR) completed the Environmental Symptoms Questionnaire (ESQ) at their respective baseline residence and again at 12, 24, 48, and 72 h at 4300m to assess the severity and prevalence of AMS. AMS cerebral factor score (AMS-C) was calculated from the ESQ at each time point. AMS was judged to be present if AMS-C was >= 0.7. Resting end-tidal CO2 (P-ETCO2) and arterial oxygen saturation (Sa(O2)) were assessed prior to and at 24, 48, and 72 h at 4300 m. Resting venous blood samples were collected prior to and at 72 h at 4300m to estimate plasma volume (PV) changes. MAR compared to SLR: 1) AMS severity at 4300 was lower (p < 0.05) at 12 h (0.50 +/- 0.69 vs. 1.48 +/- 1.28), 24 h (0.15 +/- 0.19 vs. 1.39 +/- 1.19), 48 h (0.10 +/- 0.18 vs. 1.37 +/- 1.49) and 72 h (0.08 +/- 0.12 vs. 0.69 +/- 0.70); 2) AMS prevalence at 4300 was lower (p < 0.05) at 12 h (22% vs. 72%), 24 h (0% vs. 56%), 48 h (0% vs. 56%), and 72 h (0% vs. 45%); 3) resting Sa(O2) (%) was lower (p < 0.05) at baseline (95 +/- 1 vs. 99 +/- 1) but higher (p < 0.05) at 4300 at 24 h (86 +/- 2 vs. 81 +/- 5), 48 h (88 +/- 3 vs. 83 +/- 6), and 72 h (88 +/- 2 vs. 83 +/- 5); and 4) PV (%) did not differ at 72 h at 4300 m in the MAR (4.5 +/- 6.7) but was reduced for the SLR (-8.1 +/- 10.4). These results suggest that ventilatory and hematological acclimatization acquired while living at moderate altitude, as indicated by a higher resting Sa(O2) and no reduction in PV during exposure to a higher altitude, is associated with greatly reduced AMS after rapid ascent to high altitude.
C1 [Staab, Janet E.; Beidleman, Beth A.; Muza, Stephen R.; Fulco, Charles S.; Cymerman, Allen] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA.
[Rock, Paul B.] Oklahoma State Univ, Ctr Hlth Sci, Ctr Aerosp & Hyperbar Med, Tulsa, OK USA.
RP Staab, JE (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, 42 Kansas St, Natick, MA 01760 USA.
EM janet.staab@us.army.mil
NR 28
TC 4
Z9 4
U1 1
U2 11
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1527-0297
J9 HIGH ALT MED BIOL
JI High Alt. Med. Biol.
PD MAR
PY 2013
VL 14
IS 1
BP 13
EP 18
DI 10.1089/ham.2012.1065
PG 6
WC Biophysics; Public, Environmental & Occupational Health; Sport Sciences
SC Biophysics; Public, Environmental & Occupational Health; Sport Sciences
GA 116CJ
UT WOS:000316859800003
PM 23537255
ER
PT J
AU Schiffer, JM
Maniatis, P
Garza, I
Steward-Clark, E
Korman, LT
Pittman, PR
Mei, JV
Quinn, CP
AF Schiffer, Jarad M.
Maniatis, Panagiotis
Garza, Ilana
Steward-Clark, Evelene
Korman, Lawrence T.
Pittman, Phillip R.
Mei, Joanne V.
Quinn, Conrad P.
TI Quantitative assessment of anthrax vaccine immunogenicity using the
dried blood spot matrix
SO BIOLOGICALS
LA English
DT Article
DE Anthrax; Emergency response; Enzyme-linked immunosorbent assay; Dried
blood spots; Protective antigen; Assay validation
ID LINKED-IMMUNOSORBENT-ASSAY; IMMUNOGLOBULIN-G; ANTIBODIES
AB The collection, processing and transportation to a testing laboratory of large numbers of clinical samples during an emergency response situation present significant cost and logistical issues. Blood and serum are common clinical samples for diagnosis of disease. Serum preparation requires significant on-site equipment and facilities for immediate processing and cold storage, and significant costs for cold-chain transport to testing facilities. The dried blood spot (DBS) matrix offers an alternative to serum for rapid and efficient sample collection with fewer on-site equipment requirements and considerably lower storage and transport costs. We have developed and validated assay methods for using DBS in the quantitative anti-protective antigen IgG enzyme-linked immunosorbent asay (ELISA), one of the primary assays for assessing immunogenicity of anthrax vaccine and for confirmatory diagnosis of Bacillus anthracis infection in humans. We have also developed and validated high-throughput data analysis software to facilitate data handling for large clinical trials and emergency response. Published by Elsevier Ltd on behalf of The International Alliance for Biological Standardization.
C1 [Schiffer, Jarad M.; Steward-Clark, Evelene; Mei, Joanne V.; Quinn, Conrad P.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Maniatis, Panagiotis; Garza, Ilana] Logist Hlth Inc, La Crosse, WI 54601 USA.
[Korman, Lawrence T.; Pittman, Phillip R.] USA, Med Res Inst Infect Dis, Ft Detrick, MD USA.
RP Schiffer, JM (reprint author), Ctr Dis Control & Prevent, Microbial Pathogenesis & Immune Response Lab, Meningitis & Vaccine Preventable Dis Branch, Div Bacterial Dis,Natl Ctr Immunizat & Resp Dis, Mail Stop D-01,1600 Clifton Rd NE, Atlanta, GA 30333 USA.
EM jschiffer@cdc.gov
FU Centers for Disease Control and Prevention, Office for Public Health
Preparedness and Response
FX This publication was supported by funds made available from the Centers
for Disease Control and Prevention, Office for Public Health
Preparedness and Response.
NR 19
TC 0
Z9 0
U1 0
U2 9
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1045-1056
J9 BIOLOGICALS
JI Biologicals
PD MAR
PY 2013
VL 41
IS 2
BP 98
EP 103
DI 10.1016/j.biologicals.2012.11.003
PG 6
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
Pharmacology & Pharmacy
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Pharmacology & Pharmacy
GA 115WX
UT WOS:000316843700007
PM 23266055
ER
PT J
AU Rostkowski, KH
Pfluger, AR
Criddle, CS
AF Rostkowski, Katherine H.
Pfluger, Andrew R.
Criddle, Craig S.
TI Stoichiometry and kinetics of the PHB-producing Type II methanotrophs
Methylosinus trichosporium OB3b and Methylocystis parvus OBBP
SO BIORESOURCE TECHNOLOGY
LA English
DT Article
DE Type II methanotrophs; Stoichiometry; Kinetics; Polyhydroxybutyrate
(PHB)
ID METHANE-UTILIZING BACTERIA; NITROGEN-FIXATION; OBLIGATE METHANOTROPHS;
AMMONIA ASSIMILATION; METABOLISM; POLY-3-HYDROXYBUTYRATE;
POLYHYDROXYALKANOATES; PROTEOBACTERIA; ENRICHMENT; OXIDATION
AB In this study, modeling is used to describe how oxygen and nitrogen source affect the stoichiometry and kinetics of growth and PHB production in the Type II methanotrophs Methylosinus trichosporium OB3b and Methylocystis parvus OBBP. Significant differences were observed, with major implications for the use of these species in biotechnology applications. Such analyses can better inform bioreactor design, scale-up models, and life cycle assessments (LCAs). Published by Elsevier Ltd.
C1 [Rostkowski, Katherine H.; Criddle, Craig S.] Stanford Univ, Dept Civil & Environm Engn, Stanford, CA 94305 USA.
[Pfluger, Andrew R.] US Mil Acad, Dept Geog & Environm Engn, West Point, NY 10996 USA.
RP Rostkowski, KH (reprint author), Stanford Univ, Dept Civil & Environm Engn, Stanford, CA 94305 USA.
EM khr4@stanford.edu
NR 35
TC 13
Z9 14
U1 5
U2 68
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0960-8524
J9 BIORESOURCE TECHNOL
JI Bioresour. Technol.
PD MAR
PY 2013
VL 132
BP 71
EP 77
DI 10.1016/j.biortech.2012.12.129
PG 7
WC Agricultural Engineering; Biotechnology & Applied Microbiology; Energy &
Fuels
SC Agriculture; Biotechnology & Applied Microbiology; Energy & Fuels
GA 113YZ
UT WOS:000316707200011
PM 23395757
ER
PT J
AU Hahs, DW
Pethel, SD
AF Hahs, Daniel W.
Pethel, Shawn D.
TI Transfer Entropy for Coupled Autoregressive Processes
SO ENTROPY
LA English
DT Article
DE transfer entropy; autoregressive process; Gaussian process; information
transfer
ID INFORMATION-TRANSFER
AB A method is shown for computing transfer entropy over multiple time lags for coupled autoregressive processes using formulas for the differential entropy of multivariate Gaussian processes. Two examples are provided: (1) a first-order filtered noise process whose state is measured with additive noise, and (2) two first-order coupled processes each of which is driven by white process noise. We found that, for the first example, increasing the first-order AR coefficient while keeping the correlation coefficient between filtered and measured process fixed, transfer entropy increased since the entropy of the measured process was itself increased. For the second example, the minimum correlation coefficient occurs when the process noise variances match. It was seen that matching of these variances results in minimum information flow, expressed as the sum of transfer entropies in both directions. Without a match, the transfer entropy is larger in the direction away from the process having the larger process noise. Fixing the process noise variances, transfer entropies in both directions increase with the coupling strength. Finally, we note that the method can be generally employed to compute other information theoretic quantities as well.
C1 [Hahs, Daniel W.] Torch Technol Inc, Huntsville, AL 35802 USA.
[Pethel, Shawn D.] USA, Huntsville, AL 35898 USA.
RP Pethel, SD (reprint author), USA, Huntsville, AL 35898 USA.
EM dan.hahs@torchtechnologies.com; shawn.d.pethel.civ@mail.mil
NR 13
TC 7
Z9 7
U1 0
U2 7
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1099-4300
J9 ENTROPY-SWITZ
JI Entropy
PD MAR
PY 2013
VL 15
IS 3
BP 767
EP 788
DI 10.3390/e15030767
PG 22
WC Physics, Multidisciplinary
SC Physics
GA 112PW
UT WOS:000316605600003
ER
PT J
AU Diallo, D
Benbouzid, ME
Abul Masrur, M
AF Diallo, Demba
Benbouzid, Mohamed El Hachemi
Abul Masrur, M.
TI Special Section on Condition Monitoring and Fault Accommodation in
Electric and Hybrid Propulsion Systems
SO IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY
LA English
DT Editorial Material
C1 [Diallo, Demba] Univ Paris 11, LGEP, UMR 8507, F-91192 Gif Sur Yvette, France.
[Benbouzid, Mohamed El Hachemi] Univ Brest, LBMS, EA 4325, F-29238 Brest 03, France.
[Abul Masrur, M.] USA, RDECOM TARDEC, RDTA RS, Warren, MI 48397 USA.
RP Diallo, D (reprint author), Univ Paris 11, LGEP, UMR 8507, F-91192 Gif Sur Yvette, France.
NR 0
TC 4
Z9 4
U1 0
U2 13
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-9545
J9 IEEE T VEH TECHNOL
JI IEEE Trans. Veh. Technol.
PD MAR
PY 2013
VL 62
IS 3
BP 962
EP 964
DI 10.1109/TVT.2013.2245731
PG 3
WC Engineering, Electrical & Electronic; Telecommunications; Transportation
Science & Technology
SC Engineering; Telecommunications; Transportation
GA 110TP
UT WOS:000316469500001
ER
PT J
AU Velez, VF
Romano, JA
McKown, RL
Green, K
Zhang, LW
Raab, RW
Ryan, DS
Hutnik, CML
Frierson, HF
Laurie, GW
AF Velez, Francisco V.
Romano, Jeffrey A.
McKown, Robert L.
Green, Kari
Zhang, Liwen
Raab, Ronald W.
Ryan, Denise S.
Hutnik, Cindy M. L.
Frierson, Henry F., Jr.
Laurie, Gordon W.
TI Tissue Transglutaminase Is a Negative Regulator of Monomeric Lacritin
Bioactivity
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Article
ID CORNEAL EPITHELIAL-CELLS; PROSECRETORY MITOGEN LACRITIN;
GROWTH-FACTOR-BETA; DRY EYE; MASS-SPECTROMETRY; EXPRESSION; ACTIVATION;
PROTEIN; IDENTIFICATION; PROLIFERATION
AB PURPOSE. Molar accounting of bioactive fluids can expose new regulatory mechanisms in the growing proteomic focus on epithelial biology. Essential for the viability of the surface epithelium of the eye and for normal vision is the thin, but protein-rich, tear film in which the small tear glycoprotein lacritin appears to play a prominent prosecretory, cytoprotective, and mitogenic role. Although optimal bioactive levels in cell culture are 1 to 10 nM over a biphasic dose optimum, ELISA suggests a sustained tear lacritin concentration in the midmicromolar range in healthy adults. Here we identify a reconciling mechanism.
METHODS. Monoclonal anti-lacritin 1F5 antibody was generated, and applied together with a new anti-C-terminal polyclonal antibody to tear and tissue Western blotting. In vitro tissue transglutaminase (Tgm2) cross-linking was monitored and characterized by mass spectrometry.
RESULTS. Blotting for lacritin in human tears or saliva surprisingly detected immunoreactive material with a higher molecular weight and prominence equal or exceeding the similar to 23 to 25 kDa band of monomeric glycosylated lacritin. Exogenous Tgm2 initiated lacritin cross-linking within 1 minute and was complete by 90 minutes-even with as little as 0.1 nM lacritin, and involved the donors lysine 82 and 85 and the acceptor glutamine 106 in the syndecan-1 binding domain. Lacritin spiked into lacritin-depleted tears formed multimers, in keeping with similar to 0.6 mu M TGM2 in tears. Cross-linking was absent when Tgm2 was inactive, and cross-linked lacritin, unlike recombinant monomer, bound syndecan-1 poorly.
CONCLUSIONS. Since syndecan-1 binding is necessary for lacritin mitogenic and cytoprotective activities, TGM2 cross-linking negatively regulates lacritin bioactivity. (Invest Ophthalmol Vis Sci. 2013; 54: 2123-2132) DOI: 10.1167/iovs.12-11488
C1 [Velez, Francisco V.; Romano, Jeffrey A.; Laurie, Gordon W.] Univ Virginia, Dept Cell Biol, Charlottesville, VA 22908 USA.
[McKown, Robert L.; Raab, Ronald W.] James Madison Univ, Dept Integrated Sci & Technol, Harrisonburg, VA 22807 USA.
[Green, Kari; Zhang, Liwen] Ohio State Univ, Dept Mol & Cellular Biochem, Columbus, OH 43210 USA.
[Green, Kari; Zhang, Liwen] Ohio State Univ, Mass Spectrometry & Prote Facil, Columbus, OH 43210 USA.
[Ryan, Denise S.] USA, Warfighter Refract Surg Res Ctr Ft Belvoir, Ft Belvoir, VA USA.
[Hutnik, Cindy M. L.] Univ Western Ontario, Dept Ophthalmol, London, ON, Canada.
[Frierson, Henry F., Jr.] Univ Virginia, Dept Pathol, Charlottesville, VA 22903 USA.
[Laurie, Gordon W.] Univ Virginia, Dept Ophthalmol, Charlottesville, VA USA.
RP Laurie, GW (reprint author), Univ Virginia, Dept Cell Biol, UVa Hlth Syst, POB 800732, Charlottesville, VA 22908 USA.
EM glaurie@virginia.edu
RI Zhang, Liwen/P-1111-2016
FU NIH [RO1EY013143, RO1EY018222]
FX Supported by NIH RO1EY013143, RO1EY018222 (GWL).
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U1 0
U2 2
PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC
PI ROCKVILLE
PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR
PY 2013
VL 54
IS 3
BP 2123
EP 2132
DI 10.1167/iovs.12-11488
PG 10
WC Ophthalmology
SC Ophthalmology
GA 117GV
UT WOS:000316942400074
ER
PT J
AU Morrison, JJ
Ross, JD
Dubose, JJ
Jansen, JO
Midwinter, MJ
Rasmussen, TE
AF Morrison, Jonathan J.
Ross, James D.
Dubose, Joseph J.
Jansen, Jan O.
Midwinter, Mark J.
Rasmussen, Todd E.
TI Association of Cryoprecipitate and Tranexamic Acid With Improved
Survival Following Wartime Injury Findings From the MATTERs II Study
SO JAMA SURGERY
LA English
DT Article
ID ACTIVATED PROTEIN-C; TRAUMA PATIENTS; ACUTE COAGULOPATHY;
CONTROLLED-TRIAL; EPIDEMIOLOGY; FIBRINOGEN; HYPERFIBRINOLYSIS;
COAGULATION; HEMORRHAGE; DEATH
AB Objective: To quantify the impact of fibrinogen-containing cryoprecipitate in addition to the antifibrinolytic tranexamic acid on survival in combat injured.
Design: Retrospective observational study comparing the mortality of 4 groups: tranexamic acid only, cryoprecipitate only, tranexamicacidandcryoprecipitate, and neither tranexamic acid nor cryoprecipitate. To balance comparisons, propensity scores were developed and added as covariates to logistic regression models predicting mortality.
Setting: A Role 3 Combat Surgical Hospital in southern Afghanistan.
Patients: A total of 1332 patients were identified from prospectively collected UK and US trauma registries who required 1 U or more of packed red blood cells and composed the following groups: tranexamic acid (n=148), cryoprecipitate (n=168), tranexamic acid/cryoprecipitate (n=258), and no tranexamic acid/cryoprecipitate (n=758).
Main Outcome Measure: In-hospital mortality.
Results: Injury Severity Scores were highest in the cryoprecipitate (mean [SD], 28.3 [15.7]) and tranexamic acid/cryoprecipitate (mean [SD], 26 [14.9]) groups compared with the tranexamic acid (mean [SD], 23.0 [19.2]) and no tranexamic acid/cryoprecipitate (mean [SD], 21.2 [18.5]) (P < .001) groups. Despite greater Injury Severity Scores and packed red blood cell requirements, mortality was lowest in the tranexamic acid/cryoprecipitate (11.6%) and tranexamic acid (18.2%) groups compared with the cryoprecipitate (21.4%) and no tranexamic acid/cryoprecipitate (23.6%) groups. Tranexamic acid and cryoprecipitate were independently associated with a similarly reduced mortality (odds ratio, 0.61; 95% CI, 0.420.89; P=.01 and odds ratio, 0.61; 95% CI, 0.40-0.94; P=.02, respectively). The combined tranexamic acid and cryoprecipitate effect vs neither in a synergy model had an odds ratio of 0.34 (95% CI, 0.20-0.58; P < .001), reflecting nonsignificant interaction (P=.21).
Conclusions: Cryoprecipitate may independently add to the survival benefit of tranexamic acid in the seriously injured requiring transfusion. Additional study is necessary to define the role of fibrinogen in resuscitation from hemorrhagic shock. JAMA Surg. 2013; 148(3): 218-225. Published online November 19, 2012. doi: 10.1001/jamasurg.2013.764
C1 [Morrison, Jonathan J.] New Queen Elizabeth Hosp, Natl Inst Hlth Res, Birmingham, W Midlands, England.
[Morrison, Jonathan J.; Midwinter, Mark J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England.
[Jansen, Jan O.] Med Regiment, Parachute Med Squadron 144, Air Assault 16, Colchester, Essex, England.
[Morrison, Jonathan J.; Rasmussen, Todd E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Ross, James D.] Lackland AFB, Med Wing Sci & Technol Off 59, San Antonio, TX USA.
[Dubose, Joseph J.] C STARS Baltimore, R Adams Cowley Shock Trauma Ctr, Baltimore, MD USA.
[Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA.
RP Rasmussen, TE (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, San Antonio, TX 78234 USA.
EM todd.rasmussen@amedd.army.mil
RI Midwinter, Mark/P-6264-2015;
OI Midwinter, Mark/0000-0003-1836-7137; Morrison,
Jonathan/0000-0001-7462-8456
FU Office of the US Air Force Surgeon General; Air Force Medical Support
Agency
FX This research was funded by the Office of the US Air Force Surgeon
General and created in the performance of a contract with the Air Force
Medical Support Agency. The governments of Great Britain and the United
States have certain rights to use this work.
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U2 6
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 2168-6254
J9 JAMA SURG
JI JAMA Surg.
PD MAR
PY 2013
VL 148
IS 3
BP 218
EP 225
DI 10.1001/jamasurg.2013.764
PG 8
WC Surgery
SC Surgery
GA 113QG
UT WOS:000316682000002
PM 23670117
ER
PT J
AU Bogetti, TA
Staniszewski, J
Burns, BP
Hoppel, CPR
Gillespie, JW
Tierney, J
AF Bogetti, Travis A.
Staniszewski, Jeffrey
Burns, Bruce P.
Hoppel, Christopher P. R.
Gillespie, John W., Jr.
Tierney, John
TI Predicting the nonlinear response and progressive failure of composite
laminates under triaxial loading: Correlation with experimental results
SO JOURNAL OF COMPOSITE MATERIALS
LA English
DT Article
DE Composite laminate; triaxial loading; progressive ply failure; nonlinear
response; envelope
ID BIAXIAL COMPRESSION; LAYERED COMPOSITES; CAPABILITIES; EXERCISE;
BENCHMARKING
AB This article represents our contribution to Part B of the 2nd Worldwide Failure Exercise (WWFE-II), where comparisons between epoxy/lamina/laminate response and failure predictions, based on maximum strain failure criterion, and experimental results are made. Correlations between actual test data and our nonlinear stress-strain response and failure envelope predictions under multi-axial loading for 12 different case studies are presented and discussed. Although our approach to modeling composite failure ranked high when applied to biaxial in-plane loading analysis, the theory does not consistently capture the inherent strengthening mechanisms that can be attributed to triaxial loading and hydrostatic pressure. It is expected that the incorporation of a strain-based ply-level failure criterion that introduces some form of strengthening mechanism under a three-dimensional stress state would significantly improve the accuracy of our predictions.
C1 [Bogetti, Travis A.; Staniszewski, Jeffrey; Burns, Bruce P.; Hoppel, Christopher P. R.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Gillespie, John W., Jr.; Tierney, John] Univ Delaware, Ctr Composite Mat, Dept Civil & Environm Engn, Newark, DE 19716 USA.
[Gillespie, John W., Jr.] Univ Delaware, Dept Mat Sci & Engn, Newark, DE USA.
RP Bogetti, TA (reprint author), USA, Res Lab, RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA.
EM travis.a.bogetti.civ@mail.mil
NR 21
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U1 0
U2 14
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0021-9983
J9 J COMPOS MATER
JI J. Compos Mater.
PD MAR
PY 2013
VL 47
IS 6-7
SI SI
BP 793
EP 804
DI 10.1177/0021998312462616
PG 12
WC Materials Science, Composites
SC Materials Science
GA 116XN
UT WOS:000316916700010
ER
PT J
AU Doyle, JD
Howard, IL
AF Doyle, Jesse D.
Howard, Isaac L.
TI Thermal Cracking Potential of High RAP-WMA Evaluated With Bending Beam
Rheometer Mixture Beam Test
SO JOURNAL OF TESTING AND EVALUATION
LA English
DT Article
DE asphalt mixture; flexible pavements; reclaimed asphalt pavement; warm
mix asphalt; thermal cracking
ID RECLAIMED ASPHALT PAVEMENT; TEMPERATURE
AB In recent years, increasing cost of the raw materials for asphalt paving has generated interest in using greater quantities of reclaimed asphalt pavement (RAP). During the same period, development of warm-mix asphalt (WMA) technology has allowed use of lower production temperatures that can reduce the amount of short-term aging of the virgin binder. The reduction in short-term aging can be beneficial in reducing problems associated with increased binder stiffness that are normally encountered when using high percentages of RAP in a mixture. This paper presents the results of an investigation that compared the low-temperature performance of WMA with a high RAP content to the performance of mixtures produced in accordance with current practice, which limits the content of RAP in the mixture to 15% or less. Comparisons were made through a combination of mixture testing with the bending beam rheometer (B BR) and thermal cracking analysis of the BBR data. Emphasis was placed on mixture performance when the mixture is used on the surface of highway pavements. Test results from over 1000 beam specimens tested in the BBR are presented, and the results indicate that low-temperature performance of WMA containing 25% RAP is likely to be comparable to performance of surface mixtures produced in accordance with current practice. The test results also indicate WMA containing 50% RAP may be more susceptible to thermal cracking than surface course mixtures produced by the current practice.
C1 [Doyle, Jesse D.] USA, Corps Engineers, Engn Res & Dev Ctr, CEERD GM A, Vicksburg, MS 39180 USA.
[Howard, Isaac L.] Mississippi State Univ, Dept Civil & Environm Engn, Mississippi State, MS 39762 USA.
RP Doyle, JD (reprint author), USA, Corps Engineers, Engn Res & Dev Ctr, CEERD GM A, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM jesse.d.doyle@erdc.dren.mil
FU Mississippi DOT Research Division [SS 212]
FX Thanks are due to the Mississippi DOT Research Division (James Watkins)
for funding SS 212. Permission to publish this paper was granted by the
Director, Geotechnical and Structures Laboratory, U.S. Army Engineer
Research and Development Center.
NR 21
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U1 3
U2 15
PU AMER SOC TESTING MATERIALS
PI W CONSHOHOCKEN
PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 USA
SN 0090-3973
EI 1945-7553
J9 J TEST EVAL
JI J. Test. Eval.
PD MAR
PY 2013
VL 41
IS 2
BP 236
EP 246
DI 10.1520/JTE20120034
PG 11
WC Materials Science, Characterization & Testing
SC Materials Science
GA 115UQ
UT WOS:000316837800008
ER
PT J
AU Wilson, DK
Valente, D
Nykaza, ET
Pettit, CL
AF Wilson, D. Keith
Valente, Dan
Nykaza, Edward T.
Pettit, Chris L.
TI Information-criterion based selection of models for community noise
annoyance
SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
LA English
DT Article
ID EXPOSURE
AB Statistical evidence for various models relating day-night sound level (DNL) to community noise annoyance is assessed with the Akaike information criterion. In particular, community-specific adjustments such as the community tolerance level (CTL, the DNL at which 50% of survey respondents are highly annoyed) and community tolerance spread (CTS, the difference between the DNL at which 90% and 10% are highly annoyed) are considered. The results strongly support models characterizing annoyance on a community-by-community basis, rather than with complete pooling and analysis of all available surveys. The most likely model was found to be a 2-parameter logistic model, with CTL and CTS fit independently to survey data from each community.
C1 [Wilson, D. Keith] USA, Engineer Res & Dev Ctr, Hanover, NH 03755 USA.
[Valente, Dan; Nykaza, Edward T.] USA, Engineer Res & Dev Ctr, Champaign, IL 61826 USA.
[Pettit, Chris L.] USN Acad, Dept Aerosp Engn, Annapolis, MD 21402 USA.
RP Wilson, DK (reprint author), USA, Engineer Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA.
EM d.keith.wilson@usace.army.mil; daniel.p.valente@usace.army.mil;
edward.t.nykaza@erdc.dren.mil; pettitcl@usna.edu
RI Wilson, D. Keith/A-4687-2012
OI Wilson, D. Keith/0000-0002-8020-6871
FU U.S. Army Engineer Research and Development Center (ERDC) Geospatial
Research and Engineering business area
FX This research was funded by the U.S. Army Engineer Research and
Development Center (ERDC) Geospatial Research and Engineering business
area. Permission to publish was granted by Director, Cold Regions
Research and Engineering Laboratory. Any opinions expressed in this
paper are those of the authors, and are not to be construed as official
positions of the funding agency or the Department of the Army unless so
designated by other authorized documents.
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U1 0
U2 8
PU ACOUSTICAL SOC AMER AMER INST PHYSICS
PI MELVILLE
PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA
SN 0001-4966
J9 J ACOUST SOC AM
JI J. Acoust. Soc. Am.
PD MAR
PY 2013
VL 133
IS 3
BP EL195
EP EL201
DI 10.1121/1.4790820
PG 7
WC Acoustics; Audiology & Speech-Language Pathology
SC Acoustics; Audiology & Speech-Language Pathology
GA 108NP
UT WOS:000316300900008
ER
PT J
AU Houston, JR
AF Houston, James R.
TI Global Sea Level Projections to 2100 Using Methodology of the
Intergovernmental Panel on Climate Change
SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING
LA English
DT Article
DE Sea level; Climates; Forecasting; Coastal environment
ID GREENLAND ICE-SHEET; TIDE GAUGES; RISE; ACCELERATION; GLACIERS;
21ST-CENTURY; AUSTRALIA; CAPS
AB Forecasts of sea-level rise by 2100 have such a wide range that objective planning is difficult. In 2007, the Intergovernmental Panel on Climate Change (IPCC) forecast a sea-level rise from 1990 to 2100 between 0.18 and 0.59 m, but they did not completely consider contributions from Greenland and Antarctica in determining the upper limit. Recent projections by others have been larger, typically 1-2 m, with Greenland and Antarctica being the greatest contributors. However, these projections are usually maximum possible rises without probabilities of occurrence, whereas the maximum IPCC projection is at the 95% confidence level with a 2.5% probability of being equaled or exceeded. Project planning and design generally require projections with associated probabilities to determine risk. This paper shows what worldwide tide gauge data tell us about sea-level rise trends and accelerations in the twentieth century, and satellite altimeter recordings tell us about the rise since the early 1990s. Using IPCC methodology, sea level projections with associated probabilities are made from 1990 to 2100. Projections of Greenland and Antarctica contributions are estimated based on satellite measurements of current ice-mass-loss trends and accelerations, and then they are added to contributions from thermal expansion and melting of glaciers and ice caps based on the latest information. Sea-level rise projections from 1990 to 2100 are 0.18, 0.48, and 0.82 m at 5, 50, and 95% confidence levels, respectively. DOI: 10.1061/(ASCE)WW.1943-5460.0000158. (C) 2013 American Society of Civil Engineers.
C1 USA, Engineer Res & Dev Ctr, Corps Engineers, Vicksburg, MS 39180 USA.
RP Houston, JR (reprint author), USA, Engineer Res & Dev Ctr, Corps Engineers, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM james.r.houston@usace.army.mil
NR 48
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Z9 3
U1 6
U2 55
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0733-950X
EI 1943-5460
J9 J WATERW PORT COAST
JI J. Waterw. Port Coast. Ocean Eng.
PD MAR
PY 2013
VL 139
IS 2
BP 82
EP 87
DI 10.1061/(ASCE)WW.1943-5460.0000158
PG 6
WC Engineering, Civil; Engineering, Ocean; Water Resources
SC Engineering; Water Resources
GA 116GV
UT WOS:000316871900002
ER
PT J
AU Atkinson, J
Smith, JM
Bender, C
AF Atkinson, John
Smith, Jane McKee
Bender, Christopher
TI Sea-Level Rise Effects on Storm Surge and Nearshore Waves on the Texas
Coast: Influence of Landscape and Storm Characteristics
SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING
LA English
DT Article
DE Sea-level rise; Storm surge; Waves; Inundation; Land cover; ADCIRC; WAM;
STWAVE; Texas; Hurricanes
ID SOUTHERN LOUISIANA; POTENTIAL IMPACT; SUBSIDENCE; HURRICANES
AB Sea-level rise (SLR) estimates vary broadly, but most estimates predict significant increases in sea levels within the next century. Through the use of validated, coupled wave and hydrodynamic models, this study investigates SLR effects on storm surge and nearshore waves, including variation with coastal landscape type and storm characteristics. Both the wave and hydrodynamic models account for bottom friction based on land-use type, so the modeling procedure accounted for SLR-related changes to land cover, in addition to higher mean sea levels. Simulation of storms with similar meteorological characteristics and track but with landfall in the northeastern and southwestern coastal areas allowed examination of how the coastal features influenced the storm surge and wave response to increased sea levels. The simulation results analyzed here demonstrate that the relationship between storm surge and relative SLR (RSLR) varies between geographic region and storm scenario. The increase in an inundated area is linear in the north, and in the south, the inundated area approaches the northern values for similar storms asymptotically. Nearshore wave results indicate, as expected, that larger water depths created by positive RSLR and amplified surge allow larger waves to propagate into inland areas. For the Texas simulations, it was found that an increase in hurricane wind speeds of 25% is approximately equivalent to a RSLR of 0.5 m in terms of increased area of inundation impact. Because of the complexities of storm-surge dependency on storm strength, track, and local topography, there is no one-size-fits-all response to RSLR descriptive of all locations. Site-specific computer modeling should be used to evaluate the risk facing coastal communities. DOI: 10.1061/(ASCE)WW.1943-5460.0000187. (C) 2013 American Society of Civil Engineers.
C1 [Atkinson, John] ARCADIS US Inc, Boulder, CO 80301 USA.
[Smith, Jane McKee] USA, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Corps Engineers, Vicksburg, MS 39180 USA.
[Bender, Christopher] Taylor Engn Inc, Jacksonville, FL 32256 USA.
RP Bender, C (reprint author), Taylor Engn Inc, 10151 Deerwood Pk Blvd,Suite 300,Bldg 300, Jacksonville, FL 32256 USA.
EM john.atkinson@arcadis-us.com; Jane.M.Smith@usace.army.mil;
cbender@taylorengineering.com
NR 36
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Z9 14
U1 1
U2 31
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0733-950X
J9 J WATERW PORT C
JI J. Waterw. Port Coast. Ocean Eng.
PD MAR
PY 2013
VL 139
IS 2
BP 98
EP 117
DI 10.1061/(ASCE)WW.1943-5460.0000187
PG 20
WC Engineering, Civil; Engineering, Ocean; Water Resources
SC Engineering; Water Resources
GA 116GV
UT WOS:000316871900004
ER
PT J
AU Flick, RE
Knuuti, K
Gill, SK
AF Flick, Reinhard E.
Knuuti, Kevin
Gill, Stephen K.
TI Matching Mean Sea Level Rise Projections to Local Elevation Datums
SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING
LA English
DT Article
DE Sea level; Sea level rise projections; Sea level rise scenarios;
Geodetic datums; Tidal datums
ID TIDES
AB A method is presented to consistently tie future mean sea level rise (MSLR) scenario projections to local geodetic and tidal datums. This extends the U. S. Army Corps of Engineer (USACE) guidance for incorporating the effects of future MSLR into coastal projects. While USACE relies on the National Oceanic and Atmospheric Administration (NOAA) 19-year National Tidal Datum Epoch (NTDE) for its datum relationships, the approach proposed herein generalizes this guidance by choosing the appropriate 19-year epoch centered on the start year of the MSLR scenario under consideration. The procedure takes into account the local annual sea level variability, which confounds the matching to any given single year while generalizing and preserving the 19-year averaging long used by NOAA to calculate the NTDE. Examples of the MSLR scenario matching procedure are given using actual data and projections for La Jolla, California, and Sewells Point (Hampton Roads), Virginia. DOI: 10.1061/(ASCE)WW.1943-5460.0000145. (C) 2013 American Society of Civil Engineers.
C1 [Flick, Reinhard E.] TerraCosta Consulting Grp, San Diego, CA 92123 USA.
[Flick, Reinhard E.] Univ Calif San Diego, Scripps Inst Oceanog, Calif Dept Boating & Waterways, La Jolla, CA 92093 USA.
[Knuuti, Kevin] USA, Corps Engineers, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
[Gill, Stephen K.] NOAA, Natl Ocean Serv, Ctr Operat Oceanog Prod & Serv, Silver Spring, MD 20910 USA.
RP Flick, RE (reprint author), TerraCosta Consulting Grp, 3890 Murphy Canyon Rd,Suite 200, San Diego, CA 92123 USA.
EM rflick@ucsd.edu
FU SPAWAR Systems Center Pacific from the Strategic Environmental Research
and Development Program (SERDP) [SI-1703]
FX This study was conducted in collaboration with SPAWAR Systems Center
Pacific under Grant No. SI-1703 from the Strategic Environmental
Research and Development Program (SERDP). This paper was markedly
improved owing to the constructive criticism from the three anonymous
reviewers to whom the authors are grateful. The contribution of SERDP
Program Manager Dr. John Hall is especially acknowledged, who asked the
key question, "Sea level rise relative to what?"
NR 21
TC 1
Z9 1
U1 1
U2 8
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0733-950X
EI 1943-5460
J9 J WATERW PORT COAST
JI J. Waterw. Port Coast. Ocean Eng.
PD MAR
PY 2013
VL 139
IS 2
BP 142
EP 146
DI 10.1061/(ASCE)WW.1943-5460.0000145
PG 5
WC Engineering, Civil; Engineering, Ocean; Water Resources
SC Engineering; Water Resources
GA 116GV
UT WOS:000316871900008
ER
PT J
AU Pelin, M
Boscolo, S
Poli, M
Sosa, S
Tubaro, A
Florio, C
AF Pelin, Marco
Boscolo, Sabrina
Poli, Mark
Sosa, Silvio
Tubaro, Aurelia
Florio, Chiara
TI Characterization of Palytoxin Binding to HaCaT Cells Using a Monoclonal
Anti-Palytoxin Antibody
SO MARINE DRUGS
LA English
DT Article
DE palytoxin; ouabain; binding; ELISA; HaCaT cells
ID CARDIAC-GLYCOSIDES; PUTATIVE PALYTOXIN; MASS-SPECTROMETRY;
OSTREOPSIS-OVATA; 1ST EVIDENCE; RED-CELLS; OUABAIN; ERYTHROCYTES;
ANALOGS; ATPASE
AB Palytoxin (PLTX) is the reference compound for a group of potent marine biotoxins, for which the molecular target is Na+/K+-ATPase. Indeed, ouabain (OUA), a potent blocker of the pump, is used to inhibit some PLTX effects in vitro. However, in an effort to explain incomplete inhibition of PLTX cytotoxicity, some studies suggest the possibility of two different binding sites on Na+/K+-ATPase. Hence, this study was performed to characterize PLTX binding to intact HaCaT keratinocytes and to investigate the ability of OUA to compete for this binding. PLTX binding to HaCaT cells was demonstrated by immunocytochemical analysis after 10 min exposure. An anti-PLTX monoclonal antibody-based ELISA showed that the binding was saturable and reversible, with a K-d of 3 x 10(-10) M. However, kinetic experiments revealed that PLTX binding dissociation was incomplete, suggesting an additional, OUA-insensitive, PLTX binding site. Competitive experiments suggested that OUA acts as a negative allosteric modulator against high PLTX concentrations (0.3-1.0 x 10(-7) M) and possibly as a non-competitive antagonist against low PLTX concentrations (0.1-3.0 x 10(-9) M). Antagonism was supported by PLTX cytotoxicity inhibition at OUA concentrations that displaced PLTX binding (1 x 10(-5) M). However, this inhibition was incomplete, supporting the existence of both OUA-sensitive and -insensitive PLTX binding sites.
C1 [Pelin, Marco; Boscolo, Sabrina; Sosa, Silvio; Tubaro, Aurelia; Florio, Chiara] Univ Trieste, Dept Life Sci, I-34127 Trieste, Italy.
[Poli, Mark] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21701 USA.
RP Tubaro, A (reprint author), Univ Trieste, Dept Life Sci, Via A Valerio 6, I-34127 Trieste, Italy.
EM marco.pelin@hotmail.it; sabribos@hotmail.com; mark.poli@us.army.mil;
silvio.sosa@econ.units.it; tubaro@units.it; florioc@units.it
FU Regione Friuli Venezia-Giulia, Direzione Risorse Rurali, Agroalimentari
e Forestali (Progetto "Kit e biosensori di elevata sensibilta per la
determinazione delle tossine di alghe nelle acque e nei prodotti ittici
del Friuli Venezia Giulia-Senstox"); Italian Ministry of Education
University and Research [PRIN 2009JS5YX9_002]
FX This work was supported by Regione Friuli Venezia-Giulia, Direzione
Risorse Rurali, Agroalimentari e Forestali (Progetto "Kit e biosensori
di elevata sensibilta per la determinazione delle tossine di alghe nelle
acque e nei prodotti ittici del Friuli Venezia Giulia-Senstox") and the
Italian Ministry of Education University and Research (PRIN
2009JS5YX9_002).
NR 37
TC 12
Z9 12
U1 0
U2 13
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1660-3397
J9 MAR DRUGS
JI Mar. Drugs
PD MAR
PY 2013
VL 11
IS 3
BP 584
EP 598
DI 10.3390/md11030584
PG 15
WC Chemistry, Medicinal
SC Pharmacology & Pharmacy
GA 112QP
UT WOS:000316607800002
PM 23442788
ER
PT J
AU Olliaro, P
Vaillant, M
Arana, B
Grogl, M
Modabber, F
Magill, A
Lapujade, O
Buffet, P
Alvar, J
AF Olliaro, Piero
Vaillant, Michel
Arana, Byron
Grogl, Max
Modabber, Farrokh
Magill, Alan
Lapujade, Olivier
Buffet, Pierre
Alvar, Jorge
TI Methodology of Clinical Trials Aimed at Assessing Interventions for
Cutaneous Leishmaniasis
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID INTENT-TO-TREAT; NON-INFERIORITY TRIALS; MEGLUMINE ANTIMONATE; TREATMENT
FAILURE; PLACEBO; GUATEMALA; EQUIVALENCE; DIAGNOSIS; KETOCONAZOLE;
MILTEFOSINE
AB The current evidence-base for recommendations on the treatment of cutaneous leishmaniasis (CL) is generally weak. Systematic reviews have pointed to a general lack of standardization of methods for the conduct and analysis of clinical trials of CL, compounded with poor overall quality of several trials. For CL, there is a specific need for methodologies which can be applied generally, while allowing the flexibility needed to cover the diverse forms of the disease. This paper intends to provide clinical investigators with guidance for the design, conduct, analysis and report of clinical trials of treatments for CL, including the definition of measurable, reproducible and clinically-meaningful outcomes. Having unified criteria will help strengthen evidence, optimize investments, and enhance the capacity for high-quality trials. The limited resources available for CL have to be concentrated in clinical studies of excellence that meet international quality standards.
C1 [Olliaro, Piero; Arana, Byron; Lapujade, Olivier] WHO Special Programme Res & Training Trop Dis WHO, UNICEF, UNDP, World Bank, Geneva, Switzerland.
[Olliaro, Piero] Univ Oxford, Ctr Trop Med & Vaccinol, Nuffield Dept Med, Churchill Hosp, Oxford, England.
[Vaillant, Michel] CRP Sante, Competence Ctr Methodol & Stat, Luxembourg, Grand Duchy Lux, Luxembourg.
[Grogl, Max; Magill, Alan] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA.
[Modabber, Farrokh] DNDi, Geneva, Switzerland.
[Buffet, Pierre] Univ Paris 06, UMR945, Paris, France.
[Buffet, Pierre] Hop La Pitie Salpetriere, APHP, Dept Parasitol, Paris, France.
[Alvar, Jorge] WHO NTD, Geneva, Switzerland.
RP Olliaro, P (reprint author), WHO Special Programme Res & Training Trop Dis WHO, UNICEF, UNDP, World Bank, Geneva, Switzerland.
EM olliarop@who.int
NR 66
TC 19
Z9 19
U1 0
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1935-2735
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD MAR
PY 2013
VL 7
IS 3
AR e2130
DI 10.1371/journal.pntd.0002130
PG 19
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 117HI
UT WOS:000316943800043
PM 23556016
ER
PT J
AU Robins, JG
Jensen, KB
Jones, TA
Waldron, BL
Peel, MD
Rigby, CW
Vogel, KP
Mitchell, RB
Palazzo, AJ
Cary, TJ
AF Robins, Joseph G.
Jensen, Kevin B.
Jones, Thomas A.
Waldron, Blair L.
Peel, Michael D.
Rigby, Craig W.
Vogel, Kenneth P.
Mitchell, Robert B.
Palazzo, Antonio J.
Cary, Timothy J.
TI Stand Establishment and Persistence of Perennial Cool-Season Grasses in
the Intermountain West and the Central and Northern Great Plains
SO RANGELAND ECOLOGY & MANAGEMENT
LA English
DT Article
DE environmental conditions; grass species; precipitation; revegetation
ID RUSSIAN WILD RYEGRASS; SEMIARID RANGELANDS; TRITICEAE GRASSES;
BROMUS-TECTORUM; SEEDLING VIGOR; CHEATGRASS; COMMUNITIES; VARIETIES
AB The choice of plant materials is an important component of revegetation following disturbance. To determine the utility and effectiveness of various perennial grass species for revegetation on varied landscapes, a meta analysis was used to evaluate the stand establishment and persistence of 18 perennial cool-season grass species in 34 field studies in the Intermountain and Great Plains regions of the United States under monoculture conditions. Combined across the 34 studies, stand establishment values ranged from 79% to 43% and stand persistence values ranged from 70% to 0%. Intermediate wheatgrass (Thinopyrum intermedium [Host] Barkworth & D. R. Dewey), tall wheatgrass (Thinopyrum ponticum [Podp.] Z.-W. Liu & R.-C. Wang), crested wheatgrass (Agropyron spp.), Siberian wheatgrass (Agropyron fragile [Roth] P. Candargy), and meadow brome (Bromus riparius Rehmann) possessed the highest stand establishment (>= 69%). There were no significant differences among the 12 species with the largest stand persistence values. Basin wildrye (Leymus cinereus (Scribn. & Merr.) A. Love), Altai wildrye (Leymus angustus [Trin.] Pilg.), slender wheatgrass (Elymus trachycaulus [Link] Gould ex Shinners), squirreltail (Elymus spp.), and Indian ricegrass (Achnatherum hymenoides [Roem. & Schult.] Barkworth) possessed lower stand persistence (<= 32%) than the majority of the other species, and Indian ricegrass (0%) possessed the lowest stand persistence of any of the species. Correlations between environmental conditions and stand establishment and persistence showed mean annual study precipitation to have the most consistent, although moderate effect (r=similar to 0.40) for establishment and persistence. This relationship was shown by the relatively poor stand establishment and persistence of most species at sites receiving less than 310 mm of annual precipitation. These results will be a tool for land managers to make decisions concerning the importance of stand establishment, stand persistence, and annual precipitation for revegetation projects on disturbed sites.
C1 [Robins, Joseph G.; Jensen, Kevin B.; Jones, Thomas A.; Waldron, Blair L.; Peel, Michael D.; Rigby, Craig W.] ARS, USDA, Forage & Range Res Lab, Logan, UT 84322 USA.
[Vogel, Kenneth P.; Mitchell, Robert B.] ARS, USDA, Grain Forage & Bioenergy Res Unit, Lincoln, NE 68583 USA.
[Palazzo, Antonio J.; Cary, Timothy J.] USACE Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
RP Robins, JG (reprint author), ARS, USDA, Forage & Range Res Lab, 6300 Old Main Hill, Logan, UT 84322 USA.
EM Joseph.Robins@ars.usda.gov
NR 27
TC 5
Z9 6
U1 1
U2 21
PU SOC RANGE MANAGEMENT
PI LAKEWOOD
PA 445 UNION BLVD, STE 230, LAKEWOOD, CO 80228-1259 USA
SN 1550-7424
J9 RANGELAND ECOL MANAG
JI Rangel. Ecol. Manag.
PD MAR
PY 2013
VL 66
IS 2
BP 181
EP 190
DI 10.2111/REM-D-11-00022.1
PG 10
WC Ecology; Environmental Sciences
SC Environmental Sciences & Ecology
GA 113CE
UT WOS:000316643000009
ER
PT J
AU Park, J
Seager, TP
Rao, PSC
Convertino, M
Linkov, I
AF Park, J.
Seager, T. P.
Rao, P. S. C.
Convertino, M.
Linkov, I.
TI Integrating Risk and Resilience Approaches to Catastrophe Management in
Engineering Systems
SO RISK ANALYSIS
LA English
DT Article
DE Adaptive management; disaster recovery; floodplain management;
resiliency
ID UNCERTAINTY; LESSONS; SCIENCE; REGIME; DESIGN; FLOOD
AB Recent natural and man-made catastrophes, such as the Fukushima nuclear power plant, flooding caused by Hurricane Katrina, the Deepwater Horizon oil spill, the Haiti earthquake, and the mortgage derivatives crisis, have renewed interest in the concept of resilience, especially as it relates to complex systems vulnerable to multiple or cascading failures. Although the meaning of resilience is contested in different contexts, in general resilience is understood to mean the capacity to adapt to changing conditions without catastrophic loss of form or function. In the context of engineering systems, this has sometimes been interpreted as the probability that system conditions might exceed an irrevocable tipping point. However, we argue that this approach improperly conflates resilience and risk perspectives by expressing resilience exclusively in risk terms. In contrast, we describe resilience as an emergent property of what an engineering system does, rather than a static property the system has. Therefore, resilience cannot be measured at the systems scale solely from examination of component parts. Instead, resilience is better understood as the outcome of a recursive process that includes: sensing, anticipation, learning, and adaptation. In this approach, resilience analysis can be understood as differentiable from, but complementary to, risk analysis, with important implications for the adaptive management of complex, coupled engineering systems. Management of the 2011 flooding in the Mississippi River Basin is discussed as an example of the successes and challenges of resilience-based management of complex natural systems that have been extensively altered by engineered structures.
C1 [Park, J.; Rao, P. S. C.] Purdue Univ, Sch Civil Engn, W Lafayette, IN 47907 USA.
[Seager, T. P.] Arizona State Univ, Ira A Fulton Sch Engn, Tempe, AZ USA.
[Linkov, I.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.
[Convertino, M.] Univ Florida, Dept Agr & Biol Engn, Gainesville, FL USA.
RP Linkov, I (reprint author), USA Corps Engineers, 696 Virginia Rd, Concord, MA 01742 USA.
EM Igor.Linkov@usace.army.mil
RI yu, jian/C-1280-2009
FU Lee A. Reith Endowment at Purdue University; Environmental Quality
Research Program of the U.S. Army Engineer Research and Development
Center
FX The authors would like to thank Dr. Martin Schultz and Paul Welle for
valuable discussions. Work completed by PSCR and JP was supported by the
Lee A. Reith Endowment at Purdue University. MC and IL would like to
acknowledge the funding from the Environmental Quality Research Program
of the U.S. Army Engineer Research and Development Center. The authors
thank E. Ferguson, the manager of this program. Permission was granted
by the USACE Chief of Engineers to publish this material. The views and
opinions expressed in this article are those of the individual authors
and not those of the U.S. Army, or other sponsor organizations.
NR 64
TC 46
Z9 57
U1 13
U2 150
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0272-4332
J9 RISK ANAL
JI Risk Anal.
PD MAR
PY 2013
VL 33
IS 3
BP 356
EP 367
DI 10.1111/j.1539-6924.2012.01885.x
PG 12
WC Public, Environmental & Occupational Health; Mathematics,
Interdisciplinary Applications; Social Sciences, Mathematical Methods
SC Public, Environmental & Occupational Health; Mathematics; Mathematical
Methods In Social Sciences
GA 109BJ
UT WOS:000316339800004
PM 22967095
ER
PT J
AU Ryan, KL
AF Ryan, Kathy L.
TI APS at 125: a look back at the founding of the American Physiological
Society
SO ADVANCES IN PHYSIOLOGY EDUCATION
LA English
DT Editorial Material
DE history; biomedical science; research ethic; American Physiological
Society
AB Ryan KL. APS at 125: a look back at the founding of the American Physiological Society. Adv Physiol Educ 37: 10-14, 2013; doi:10.1152/advan.00143.2012.-Early efforts in physiological research in the United States were produced by lone investigators working in laboratories funded by their own medical practices. In Europe, however, Claude Bernard and Carl Ludwig produced a new model of scientific research laboratories funded by the state that sought to develop the pursuit of biomedical research as an occupation. American physicians such as Henry Pickering Bowditch and S. Weir Mitchell were exposed to this new "research ethic" during their international studies and brought this new perspective home to America. Along with H. Newell Martin, these men began training professional physiologists who would assume new research positions in academic institutions. In 1887, Bowditch, Mitchell, and H. Newell Martin proposed the formation of a new society for these professional physiologists, the American Physiological Society (APS). Seventeen of the original twenty-eight members met on December 30, 1887, in New York City, NY, to establish APS. From these humble beginnings, APS evolved to become a force for change in American biomedical science.
C1 [Ryan, Kathy L.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Ryan, KL (reprint author), USA, Inst Surg Res, Regulatory Compliance Div, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM Kathy.ryan@amedd.army.mil
NR 22
TC 1
Z9 1
U1 1
U2 1
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1043-4046
J9 ADV PHYSIOL EDUC
JI Adv. Physiol. Educ.
PD MAR
PY 2013
VL 37
IS 1
BP 10
EP 14
DI 10.1152/advan.00143.2012
PG 5
WC Education, Scientific Disciplines; Physiology
SC Education & Educational Research; Physiology
GA 103YG
UT WOS:000315954800002
PM 23471243
ER
PT J
AU Upreti, SR
Janusz, KB
Schluter, WW
Bichha, RP
Shakya, G
Biggerstaff, BJ
Shrestha, MM
Sedai, TR
Fischer, M
Gibbons, RV
Shrestha, SK
Hills, SL
AF Upreti, Shyam Raj
Janusz, Kristen B.
Schluter, W. William
Bichha, Ram Padarath
Shakya, Geeta
Biggerstaff, Brad J.
Shrestha, Murari Man
Sedai, Tika Ram
Fischer, Marc
Gibbons, Robert V.
Shrestha, Sanjaya K.
Hills, Susan L.
TI Estimation of the Impact of a Japanese Encephalitis Immunization Program
with Live, Attenuated SA 14-14-2 Vaccine in Nepal
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID KATHMANDU; VIRUS
AB Wider availability of the live, attenuated SA 14-14-2 Japanese encephalitis (JE) vaccine has facilitated introduction or expansion of immunization programs in many countries. However, information on their impact is limited. In 2006, Nepal launched a JE immunization program, and by 2009, mass campaigns had been implemented in 23 districts. To describe the impact, we analyzed surveillance data from 2004 to 2009 on laboratory-confirmed JE and clinical acute encephalitis syndrome (AES) cases. The post-campaign JE incidence rate of 1.3 per 100,000 population was 72% lower than expected if no campaigns had occurred, and an estimated 891 JE cases were prevented. In addition, AES incidence was 58% lower, with an estimated 2,787 AES cases prevented, suggesting that three times as many disease cases may have been prevented than indicated by the laboratory-confirmed JE cases alone. These results provide useful information on preventable JE disease burden and the potential value of JE immunization programs.
C1 [Upreti, Shyam Raj] Minist Hlth & Populat, Child Hlth Div, Kathmandu, Nepal.
[Janusz, Kristen B.; Fischer, Marc; Hills, Susan L.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Arboviral Dis Branch, Ft Collins, CO 80521 USA.
[Schluter, W. William; Shrestha, Murari Man; Sedai, Tika Ram] WHO, Programme Immunizat Preventable Dis, Kathmandu, Nepal.
[Bichha, Ram Padarath] Kanti Childrens Hosp, Kathmandu, Nepal.
[Shakya, Geeta] Natl Publ Hlth Lab, Kathmandu, Nepal.
[Biggerstaff, Brad J.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Off Director, Ft Collins, CO 80521 USA.
[Gibbons, Robert V.] Armed Forces Res Inst Med Sci, US Army Med Component, Bangkok 10400, Thailand.
RP Hills, SL (reprint author), Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div Vector Borne Dis, Arboviral Dis Branch, 3156 Rampart Rd, Ft Collins, CO 80521 USA.
EM drshyam@hotmail.com; kbjanusz@aol.com; schluterw@wpro.who.int;
drrpbichha@gmail.com; geetanphl@yahoo.com; bbiggerstaff@cdc.gov;
Shresthamu@searo.who.int; Sedait@searo.who.int; mfischer@cdc.gov;
Robert.Gibbons@afrims.org; shresthask@afrims.org; shills@cdc.gov
FU Bill & Melinda Gates Foundation through the US Centers for Disease
Control and Prevention
FX The Bill & Melinda Gates Foundation provided financial support for this
evaluation through a grant to the US Centers for Disease Control and
Prevention.
NR 20
TC 11
Z9 11
U1 0
U2 6
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD MAR
PY 2013
VL 88
IS 3
BP 464
EP 468
DI 10.4269/ajtmh.12-0196
PG 5
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 106QC
UT WOS:000316158800012
PM 23358643
ER
PT J
AU Resnik, L
Adams, L
Borgia, M
Delikat, J
Disla, R
Ebner, C
Walters, LS
AF Resnik, Linda
Adams, Laurel
Borgia, Matthew
Delikat, Jemy
Disla, Roxanne
Ebner, Christopher
Walters, Lisa Smurr
TI Development and Evaluation of the Activities Measure for Upper Limb
Amputees
SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
LA English
DT Article
DE Amputation; Disability evaluation; Psychometrics; Rehabilitation; Upper
extremity
ID MYOELECTRIC CONTROL; AMPUTATION; ORTHOTICS; CAPACITY; HEALTH; ARM
AB Objectives: (1) To develop a measure of activities for adults with upper limb amputation: the Activities Measure for Upper Limb Amputees (AM-ULA); and (2) to conduct initial psychometric evaluation of the measure.
Design: This was a cohort study where the prototype measure was administered twice within 1 week. Tests were videotaped and graded by 2 independent raters. Interrater reliability, test-retest reliability, internal consistency, and minimal detectable change were estimated. Known group validity was examined using analyses of variance comparing scores of transradial, transhumeral, and shoulder level amputees. Convergent validity was examined by correlating AM-ULA scores with dexterity tests and self-reported function.
Setting: Hospital outpatient.
Participants: Subjects (N = 52) with upper limb amputation.
Interventions: Not applicable.
Main Outcome Measures: Not applicable.
Results: Intraclass correlation coefficients (ICCs) for test-retest reliability were .88 to .91. ICCs for interraterreliability were .84 to .89. Cronbach alphas were .89 to .91. The minimal detectable change at the 90% confidence interval was 3.7 points. Subjects with more distal levels of limb loss had better scores than those with more proximal levels (P<.01). The AM-ULA was moderately correlated with most dexterity tests and self-reported function.
Conclusions: The AM-ULA is a new measure of activity performance for adults with upper limb amputation that considers task completion, speed, movement quality, skillfulness of prosthetic use, and independence in its rating system. It has good interrater reliability, test-retest reliability, and demonstrated known group validity. Archives of Physical Medicine and Rehabilitation 2013;94:488-94 (C) 2013 by the American Congress of Rehabilitation Medicine
C1 [Resnik, Linda; Borgia, Matthew] Providence VA Med Ctr, Providence, RI 02908 USA.
[Resnik, Linda] Brown Univ, Providence, RI 02912 USA.
[Adams, Laurel; Delikat, Jemy] James A Haley Vet Hosp, Rehabil Res & Dev Ctr Excellence, Tampa, FL 33612 USA.
[Disla, Roxanne] New York Harbor Healthcare Syst, Manhattan Vet Adm, New York, NY USA.
[Ebner, Christopher; Walters, Lisa Smurr] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA.
RP Resnik, L (reprint author), Providence VA Med Ctr, 830 Chalkstone Ave, Providence, RI 02908 USA.
EM Linda.Resnik@va.gov
FU Office of Research and Development Rehabilitation Research and
Development Service, Department of Veterans Affairs [A6780I]
FX Supported by the Office of Research and Development Rehabilitation
Research and Development Service, Department of Veterans Affairs (grant
no. A6780I).
NR 24
TC 7
Z9 7
U1 1
U2 13
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0003-9993
J9 ARCH PHYS MED REHAB
JI Arch. Phys. Med. Rehabil.
PD MAR
PY 2013
VL 94
IS 3
BP 488
EP 494
DI 10.1016/j.apmr.2012.10.004
PG 7
WC Rehabilitation; Sport Sciences
SC Rehabilitation; Sport Sciences
GA 106PZ
UT WOS:000316158500012
PM 23085376
ER
PT J
AU DeLellis, SM
Anderson, SE
Lynch, JH
Kratz, K
AF DeLellis, Stephen M.
Anderson, Steven E.
Lynch, James H.
Kratz, Kris
TI Acute Mountain Sickness Prophylaxis: A High-Altitude Perspective
SO CURRENT SPORTS MEDICINE REPORTS
LA English
DT Review
ID PLACEBO-CONTROLLED TRIAL; GINKGO-BILOBA; PULMONARY-EDEMA; PREVENTION;
ILLNESS; ACETAZOLAMIDE; SILDENAFIL
AB Acute mountain sickness (AMS) is the most common form of altitude illness affecting athletes and adventurists who work or play at elevations greater than 10,000 ft above mean sea level. Considerable research has been conducted to mitigate risk for those who work or play in environmental extremes. This article describes the experiences of a group of U. S. Army Special Operations soldiers who tested recommended doses of acetazolamide prophylaxis for AMS during six expeditions to elevations between 19,000 and 23,000 ft. In addition, we briefly review the literature as it pertains to prophylaxis of AMS. In our experience, prophylaxis with the recommended doses of acetazolamide resulted in fewer AMS symptoms and seemed to confer a higher likelihood of successfully summiting each peak. We conclude that acetazolamide is an acceptable choice for AMS prevention along with a slow, controlled ascent and proper fitness, nutrition, clothing, and gear.
C1 [DeLellis, Stephen M.; Anderson, Steven E.; Lynch, James H.; Kratz, Kris] Womack Family Med Clin, Womack Army Med Ctr, Dept Army, Ft Bragg, NC 28310 USA.
RP DeLellis, SM (reprint author), Womack Family Med Clin, Womack Army Med Ctr, Dept Army, Ft Bragg, NC 28310 USA.
EM delelliss@aosa.army.mil
NR 26
TC 3
Z9 4
U1 1
U2 26
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1537-890X
J9 CURR SPORT MED REP
JI Curr. Sport. Med. Rep.
PD MAR-APR
PY 2013
VL 12
IS 2
BP 110
EP 114
DI 10.1249/JSR.0b013e3182874d0f
PG 5
WC Sport Sciences
SC Sport Sciences
GA 106DF
UT WOS:000316121400013
PM 23478562
ER
PT J
AU Ingram, BJ
Raymond, TJ
AF Ingram, Benjamin J.
Raymond, Tyler J.
TI Recognition and Treatment of Freezing and Nonfreezing Cold Injuries
SO CURRENT SPORTS MEDICINE REPORTS
LA English
DT Review
ID SOCIETY PRACTICE GUIDELINES; SEVERE FROSTBITE; PREVENTION; CHILBLAINS;
EXTREMITIES; MANAGEMENT; AMPUTATION; THERAPY; TRIAL
AB This article reviews recent medical literature to provide an overview of the recognition and treatment of the two broad categories of cold injuries, freezing and nonfreezing. Frostbite, a freezing cold injury, is treated traditionally with rapid rewarming followed by tissue care and surgical debridement of necrotic tissue. Recently, newer therapies aimed at prevention of tissue necrosis have shown improved outcomes compared with more traditional therapies. These newer treatment regimens for frostbite include the use of various drugs such as ibuprofen, aspirin, warfarin, tissue plasminogen activator, and prostacyclin. The use of Tc-99m bone scans, magnetic resonance imaging arthrogram, or angiography may have prognostic value for early determination of the extent of tissue loss. The more common nonfreezing cold injuries, though less severe than frostbite, may lead to short- and long-term complications requiring treatment and are discussed also.
C1 [Ingram, Benjamin J.; Raymond, Tyler J.] Womack Army Med Ctr, Ft Bragg, NC 28307 USA.
RP Ingram, BJ (reprint author), Womack Army Med Ctr, 2817 Reilly Rd,Stop A, Ft Bragg, NC 28307 USA.
EM Benjamin.James.Ingram@us.army.mil
NR 32
TC 8
Z9 8
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1537-890X
J9 CURR SPORT MED REP
JI Curr. Sport. Med. Rep.
PD MAR-APR
PY 2013
VL 12
IS 2
BP 125
EP 130
DI 10.1249/JSR.0b013e3182877454
PG 6
WC Sport Sciences
SC Sport Sciences
GA 106DF
UT WOS:000316121400016
PM 23478565
ER
PT J
AU Sulkowski, MS
Poordad, F
Manns, MP
Bronowicki, JP
Reddy, KR
Harrison, SA
Afdhal, NH
Sings, HL
Pedicone, LD
Koury, KJ
Sniukiene, V
Burroughs, MH
Albrecht, JK
Brass, CA
Jacobson, IM
AF Sulkowski, Mark S.
Poordad, Fred
Manns, Michael P.
Bronowicki, Jean-Pierre
Reddy, K. Rajender
Harrison, Stephen A.
Afdhal, Nezam H.
Sings, Heather L.
Pedicone, Lisa D.
Koury, Kenneth J.
Sniukiene, Vilma
Burroughs, Margaret H.
Albrecht, Janice K.
Brass, Clifford A.
Jacobson, Ira M.
CA SPRINT-2 Trial Investigators
TI Anemia during treatment with peginterferon Alfa-2b/ribavirin and
boceprevir: Analysis from the serine protease inhibitor therapy 2
(SPRINT-2) trial
SO HEPATOLOGY
LA English
DT Article
ID CHRONIC HEPATITIS-C; GENOTYPE 1 INFECTION; INTERFERON-ALPHA-2B PLUS
RIBAVIRIN; VIRUS-INFECTION; COMBINATION THERAPY; TELAPREVIR; ALPHA-2A
AB Boceprevir (BOC) added to peginterferon alfa-2b (PegIFN) and ribavirin (RBV) significantly increases sustained virologic response (SVR) rates over PegIFN/RBV alone in previously untreated adults with chronic hepatitis C genotype 1. We evaluate the relationship of incident anemia with triple therapy. A total of 1,097 patients received a 4-week lead-in of PegIFN/RBV followed by: (1) placebo plus PegIFN/RBV for 44 weeks (PR48); (2) BOC plus PegIFN/RBV using response-guided therapy (BOC/RGT); and (3) BOC plus PegIFN/RBV for 44 weeks (BOC/PR48). The management of anemia (hemoglobin [Hb] <10 g/dL) included RBV dose reduction and/or erythropoietin (EPO) use. A total of 1,080 patients had 1 Hb measurement during treatment. The incidence of anemia was 50% in the BOC arms combined (363/726) and 31% in the PR48 arm (108/354, P < 0.001). Among BOC recipients, lower baseline Hb and creatinine clearance were associated with incident anemia. In the BOC-containing arms, anemia was managed by the site investigators as follows: EPO without RBV dose reduction, 38%; RBV dose reduction without EPO, 8%; EPO with RBV dose reduction, 40%; and neither RBV dose reduction nor EPO, 14%. SVR rates were not significantly affected by management strategy (70%-74%), and overall patients with anemia had higher rates of SVR than those who did not develop anemia (58%). Serious and life-threatening adverse events (AEs) and discontinuations due to AEs among BOC-treated patients did not differ by EPO use. Conclusion: With BOC/PR therapy, SVR rates in patients with incident anemia were higher than nonanemic patients and did not vary significantly according to the investigator-selected approach for anemia management. Prospective studies are needed to confirm this observation. (HEPATOLOGY 2013)
C1 [Sulkowski, Mark S.] Johns Hopkins Univ, Sch Med, Baltimore, MD 21287 USA.
[Poordad, Fred] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA.
[Manns, Michael P.] Hannover Med Sch, Hannover, Germany.
[Bronowicki, Jean-Pierre] Univ Lorraine, Ctr Hosp Univ Nancy, INSERM, U954, Nancy, France.
[Reddy, K. Rajender] Univ Penn, Philadelphia, PA 19104 USA.
[Harrison, Stephen A.] Brooke Army Med Ctr, San Antonio, TX USA.
[Afdhal, Nezam H.] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA.
[Sings, Heather L.; Pedicone, Lisa D.; Koury, Kenneth J.; Sniukiene, Vilma; Burroughs, Margaret H.; Albrecht, Janice K.; Brass, Clifford A.] Merck Sharp & Dohme Corp, Whitehouse Stn, NJ USA.
[Jacobson, Ira M.] Weill Cornell Med Coll, New York, NY USA.
RP Sulkowski, MS (reprint author), Johns Hopkins Univ, Sch Med, 600 North Wolfe St,1830,Bldg,Suite 445, Baltimore, MD 21287 USA.
EM msulkowski@jhmi.edu
RI Bowlus, Christopher/N-9276-2016;
OI Bowlus, Christopher/0000-0002-3906-6811; Vargas,
Hugo/0000-0002-7802-688X
FU Schering-Plough; Abbott; Bristol-Myers Squibb; BoehringerIngelheim;
Gilead; Janssen; Merck; Novartis; Pfizer; Vertex; Achillion; Genentech;
Salix; Idenix; Tibotec; GlaxoSmithKline
FX Sponsored by Schering-Plough (now part of Merck Sharp & Dohme Corp., a
subsidiary of Merck & Co., Inc., Whitehouse Station, NJ).; Mark S.
Sulkowski has received consultancy fees and has grants/grants pending
from Abbott, Bristol-Myers Squibb, BoehringerIngelheim, Gilead, Janssen,
Merck, Novartis, Pfizer, and Vertex. Fred Poordad has received
consultancy fees from Merck, Vertex, Abbott, Gilead, Achillion,
Genentech, and Tibotec; has grants/grants pending from Merck; and has
received payment for development of educational presentations and
speaker fees from Merck, Genentech, Salix, and Gilead. Michael P. Manns
has received consultancy fees from Achillion, Schering-Plough (now part
of Merck), Roche, Bristol-Myers Squibb, Gilead, Boehringer-Ingelheim,
Novartis, Idenix, Tibotec, Vertex, GlaxoSmithKline, and Merck; has
grants/grants pending from Schering-Plough (now part of Merck), Roche,
Gilead, Novartis, Boehringer-Ingelheim, and Bristol-Myers Squibb; and
has received payment for development of educational presentations from
Schering-Plough (now part of Merck), Roche, Bristol-Myers Squibb,
GlaxoSmithKline, and Gilead. Jean-Pierre Bronowicki has received
consultancy fees from Schering-Plough (now part of Merck), Roche,
Gilead, Bristol-Myers Squibb, Janssen, Boehringer Ingelheim, Novartis,
and Bayer; payment for lectures including service on speakers bureaus
for Schering-Plough (now part of Merck), Roche, Bayer, and Bristol-Myers
Squibb and travel/accommodations/meeting expenses unrelated to
activities listed from Roche. K. Rajender Reddy has received consultancy
fees from Roche, Merck, Salix, Vertex, Tibotec, and Human Genome
Science; has grants/grants pending from Roche, Vertex, Tibotec,
Bristol-Myers Squibb, and Gilead; and payment for development of
educational presentations from ViralEd. Stephen A. Harrison has received
grant support from Merck, is an advisory board member for Merck and
Vertex; has grants/grants pending from Genentech and Bristol-Myers
Squibb; and has received payment for lectures, including service on
speakers bureaus for Merck. Nezam H. Afdhal has received grant support
from Merck, Gilead, Vertex, GSK, Abbott, BMS, and Pharmasett. He has
been a scientific advisor or consultant for Gilead, Vertex, Merck,
Novartis, Tibotec, Johnson and Johnson, Medgenics, and Springbank.
Heather L. Sings, Kenneth Koury, and Margaret H. Burroughs are employees
of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., and
hold stock and/or stock options. Vilma Sniukiene, Janice K. Albrecht,
Clifford A. Brass and Lisa D Pedicone are former employees of Merck
Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., and hold stock
and/or stock options. Ira M. Jacobson has received consultancy fees from
Bristol-Myers Squibb, Novartis, Gilead, Merck, Pfizer, Vertex,
GlobeImmune, Boehringer-Ingelheim, Pharmasset, Tibotec, Abbott,
Roche/Genentech, and Tibotec; Achillion, and GlaxoSmithKline; has
grants/grants pending from Abbott, Merck, Tibotec, Roche/Genentech,
Pharmasset, Boehringer Ingelheim, Novartis, Gilead, Vertex, GlobeImmune,
Human Genome Sciences, Pfizer, and Bristol-Myers Squibb; payment for
lectures including service on speakers bureaus from Merck, Vertex,
Gilead, Bristol-Myers Squibb, Roche/Genentech, and Vertex; and payment
for development of educational presentations from Bristol-Myers Squibb,
Gilead, and Vertex.
NR 22
TC 47
Z9 48
U1 0
U2 18
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
J9 HEPATOLOGY
JI Hepatology
PD MAR
PY 2013
VL 57
IS 3
BP 974
EP 984
DI 10.1002/hep.26096
PG 11
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 099TG
UT WOS:000315644200018
PM 23081753
ER
PT J
AU Veliadis, V
Steiner, B
Lawson, K
Bayne, SB
Urciuoli, D
Ha, HC
El-Hinnawy, N
Gupta, S
Borodulin, P
Howell, RS
Scozzie, C
AF Veliadis, V.
Steiner, B.
Lawson, K.
Bayne, S. B.
Urciuoli, D.
Ha, H. C.
El-Hinnawy, N.
Gupta, S.
Borodulin, P.
Howell, R. S.
Scozzie, C.
TI Reliable Operation of SiC JFET Subjected to Over 2.4 Million
1200-V/115-A Hard Switching Events at 150 degrees C
SO IEEE ELECTRON DEVICE LETTERS
LA English
DT Article
DE Bidirectional; fault isolation; four quadrants; hard switching; high
temperature; high voltage; JFET; normally ON (N-ON); pulsing;
reliability; SiC; solid-state circuit breaker (SSCB); 1200 V
AB A requirement for the commercialization of power SiC transistors is their long-term reliable operation under hard switching conditions and high temperatures encountered in the field. Normally ON 1200-V vertical-channel implanted-gate SiC JFETs, designed for high-power bidirectional (four-quadrant) solid-state circuit breaker applications, were repetitively pulsed hard switched at 150 degrees C from a 1200-V blocking state to an ON-state current of 115 A, which is in excess of 13 times the JFET's 250-W/cm(2) rated current at 150 degrees C. The JFETs were fabricated in seven photolithographic levels with a single masked ion implantation forming the p(+) gates and guard rings and with no epitaxial regrowth. The pulsed testing was performed using a low-inductance RLC circuit. In this circuit, the energy initially stored in a capacitor is discharged in a load resistor through the JFET under test. The JFET hard switch stressing included over 2.4 million 1200-V/115-A hard switch events at 150 degrees C and at a repetition rate of 10 Hz. The peak energies and powers dissipated by the JFET at each hard switch event were 73.2 mJ and 68.2 kW, respectively. The current rise rate was 166 A/mu s, and the pulse FWHM was 1.8 mu s. After over 2.4 million hard switch events at 150 degrees C, the JFET blocking voltage characteristics remained unchanged while the ON-state current conduction slightly improved, which indicate reliable operation.
C1 [Veliadis, V.; Ha, H. C.; El-Hinnawy, N.; Gupta, S.; Borodulin, P.; Howell, R. S.] Northrop Grumman Elect Syst, Linthicum, MD 21090 USA.
[Steiner, B.; Lawson, K.; Bayne, S. B.] Texas Tech Univ, Lubbock, TX 79409 USA.
[Urciuoli, D.; Scozzie, C.] USA, Res Lab, Adelphi, MD 20783 USA.
RP Veliadis, V (reprint author), Northrop Grumman Elect Syst, Linthicum, MD 21090 USA.
EM victor.veliadis@ngc.com
FU U.S. Army Research Laboratory
FX Manuscript received November 28, 2012; revised January 11, 2013;
accepted January 16, 2013. Date of publication February 11, 2013; date
of current version February 20, 2013. This work was supported by the
U.S. Army Research Laboratory. The review of this letter was arranged by
Editor C. P. Yue.
NR 9
TC 10
Z9 10
U1 1
U2 7
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0741-3106
EI 1558-0563
J9 IEEE ELECTR DEVICE L
JI IEEE Electron Device Lett.
PD MAR
PY 2013
VL 34
IS 3
BP 384
EP 386
DI 10.1109/LED.2013.2241724
PG 3
WC Engineering, Electrical & Electronic
SC Engineering
GA 100SP
UT WOS:000315723000018
ER
PT J
AU Elbadry, M
Sadhu, B
Qiu, JX
Harjani, R
AF Elbadry, Mohammad
Sadhu, Bodhisatwa
Qiu, Joe X.
Harjani, Ramesh
TI Dual-Channel Injection-Locked Quadrature LO Generation for a 4-GHz
Instantaneous Bandwidth Receiver at 21-GHz Center Frequency
SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES
LA English
DT Article; Proceedings Paper
CT IEEE Radio Frequency Integrated Circuits (RFIC) Symposium in Conjunction
with the IEEE MTT-S International Microwave Symposium (IMS) / Microwave
Week
CY JUN 17-19, 2012
CL Montreal, CANADA
SP IEEE, IEEE MTT S
DE Channelized receiver; divider; injection-locked frequency divider
(ILFD); injection-locked frequency multiplier (ILFM); injection locking;
instantaneous wideband; multiplier injection-locked oscillator (ILO);
oscillator; quadrature; quadrature voltage-controlled oscillator (QVCO);
voltage-controlled oscillator (VCO)
ID SPIRAL INDUCTORS; CMOS; TRANSCEIVER; AMPLITUDE; DESIGN; VCO
AB This paper presents a local oscillator (LO) generation scheme for a 21-GHz center-frequency 4-GHz instantaneous bandwidth channelized receiver. A single 1.33-GHz reference source is used to simultaneously generate 20- and 22-GHz LOs with quadrature outputs. Injection locking is used instead of conventional phase-locked loop techniques allowing low-power quadrature generation. A harmonic-rich signal, containing both even and odd harmonics of the input reference signal, is generated using a digital pulse slimmer. Two injection-locked oscillator chains are used to lock on to the 10th and 11th harmonics of the reference signal generating the 20- and 22-GHz quadrature LOs, respectively. The prototype design is implemented in IBM's 130-nm CMOS process, draws 110 mA from a 1.2-V supply, and occupies an active area of 1.8 mm.(2)
C1 [Elbadry, Mohammad; Sadhu, Bodhisatwa; Harjani, Ramesh] Univ Minnesota, Dept Elect & Comp Engn, Minneapolis, MN 55455 USA.
[Qiu, Joe X.] USA, Res Lab, Adelphi, MD 20783 USA.
RP Elbadry, M (reprint author), Univ Minnesota, Dept Elect & Comp Engn, Minneapolis, MN 55455 USA.
EM elbadry@umn.edu; sadhu002@umn.edu; joe.qiu@us.army.mil; harjani@umn.edu
RI Sadhu, Bodhisatwa/K-7176-2014
OI Sadhu, Bodhisatwa/0000-0002-5849-9006
NR 28
TC 6
Z9 6
U1 2
U2 11
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-9480
EI 1557-9670
J9 IEEE T MICROW THEORY
JI IEEE Trans. Microw. Theory Tech.
PD MAR
PY 2013
VL 61
IS 3
SI SI
BP 1186
EP 1199
DI 10.1109/TMTT.2013.2241784
PG 14
WC Engineering, Electrical & Electronic
SC Engineering
GA 104AM
UT WOS:000315961300019
ER
PT J
AU Kastenmuller, K
Espinosa, DA
Trager, L
Stoyanov, C
Salazar, AM
Pokalwar, S
Singh, S
Dutta, S
Ockenhouse, CF
Zavala, F
Seder, RA
AF Kastenmueller, Kathrin
Espinosa, Diego A.
Trager, Lauren
Stoyanov, Cristina
Salazar, Andres M.
Pokalwar, Santosh
Singh, Sanjay
Dutta, Sheetij
Ockenhouse, Christian F.
Zavala, Fidel
Seder, Robert A.
TI Full-Length Plasmodium falciparum Circumsporozoite Protein Administered
with Long-Chain Poly(I.C) or the Toll-Like Receptor 4 Agonist
Glucopyranosyl Lipid Adjuvant-Stable Emulsion Elicits Potent Antibody
and CD4(+) T Cell Immunity and Protection in Mice
SO INFECTION AND IMMUNITY
LA English
DT Article
ID MALARIA VACCINE RTS,S/AS02A; STRANDED-RNA POLY(I-C); MURINE MALARIA;
SPOROZOITE VACCINE; CONFERS PROTECTION; GAMMA-INTERFERON; STAGE MALARIA;
PHASE-3 TRIAL; CUTTING EDGE; NAIVE ADULTS
AB The Plasmodium falciparum circumsporozoite (CS) protein (CSP) is a major vaccine target for preventing malaria infection. Thus, developing strong and durable antibody and T cell responses against CSP with novel immunogens and potent adjuvants may improve upon the success of current approaches. Here, we compare four distinct full-length P. falciparum CS proteins expressed in Escherichia coli or Pichia pastoris for their ability to induce immunity and protection in mice when administered with long-chain poly(I.C) [poly(I.C) LC] as an adjuvant. CS proteins expressed in E. coli induced high-titer antibody responses against the NANP repeat region and potent CSP-specific CD4(+) T cell responses. Moreover, E. coli-derived CS proteins in combination with poly(I.C) LC induced potent multifunctional (interleukin 2-positive [IL-2(+)], tumor necrosis factor alpha-positive [TNF-alpha(+)], gamma interferon-positive [IFN-gamma(+)]) CD4(+) effector T cell responses in blood, in spleen, and particularly in liver. Using transgenic Plasmodium berghei expressing the repeat region of P. falciparum CSP [Pb-CS(Pf)], we showed that there was a 1- to 4-log decrease in malaria rRNA in the liver following a high-dose challenge and similar to 50% sterilizing protection with a low-dose challenge compared to control levels. Protection was directly correlated with high-level antibody titers but not CD4(+) T cell responses. Finally, protective immunity was also induced using the Toll-like receptor 4 agonist glucopyranosyl lipid adjuvant-stable emulsion (GLA-SE) as the adjuvant, which also correlated with high antibody titers yet CD4(+) T cell immunity that was significantly less potent than that with poly(I.C) LC. Overall, these data suggest that full-length CS proteins and poly(I.C) LC or GLA-SE offer a simple vaccine formulation to be used alone or in combination with other vaccines for preventing malaria infection.
C1 [Kastenmueller, Kathrin; Trager, Lauren; Stoyanov, Cristina; Seder, Robert A.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
[Kastenmueller, Kathrin; Trager, Lauren; Stoyanov, Cristina; Seder, Robert A.] NIAID, Cellular Immunol Sect, NIH, Bethesda, MD 20892 USA.
[Espinosa, Diego A.; Stoyanov, Cristina; Zavala, Fidel] Johns Hopkins Univ, Dept Mol Microbiol & Immunol, Bloomberg Sch Publ Hlth, Baltimore, MD USA.
[Salazar, Andres M.] Oncovir, Washington, DC USA.
[Pokalwar, Santosh; Singh, Sanjay] Gennova Biopharmaceut Ltd, Pune, Maharashtra, India.
[Dutta, Sheetij; Ockenhouse, Christian F.] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA.
[Trager, Lauren] Virginia Polytech Inst & State Univ, Virginia Maryland Reg Coll Vet Med, Blacksburg, VA 24061 USA.
RP Seder, RA (reprint author), NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM rseder@mail.nih.gov
FU MVI
FX We thank MVI for funding and facilitating this comparative study by
identifying and accessing the proteins and ensuring agreement of all
partners on the final study design. We thank Gennova Biopharmaceuticals
and WRAIR for providing the proteins CSP1 and CSP2, respectively.
NR 71
TC 13
Z9 14
U1 0
U2 17
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0019-9567
J9 INFECT IMMUN
JI Infect. Immun.
PD MAR
PY 2013
VL 81
IS 3
BP 789
EP 800
DI 10.1128/IAI.01108-12
PG 12
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 108RH
UT WOS:000316313200020
PM 23275094
ER
PT J
AU Edwards, E
Belard, JL
Glowa, J
Khalsa, P
Weber, W
Huntley, K
AF Edwards, Emmeline
Belard, Jean Louis
Glowa, John
Khalsa, Partap
Weber, Wendy
Huntley, Kristen
TI DoD-NCCAM/NIH Workshop on Acupuncture for Treatment of Acute Pain
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
ID DOUBLE-BLINDED TRIAL; RANDOMIZED CONTROLLED-TRIAL; PREHOSPITAL
ANALGESIA; ACUPRESSURE; COMPLEMENTARY; MEDICINE; TRAUMA; CARE; TOOL
AB The Department of Defense (DoD) and the National Center for Complementary and Alternative Medicine (NCCAM) at the National Institutes of Health (NIH) cosponsored a workshop that explored the possible benefits of acupuncture treatment for acute pain. One goal of the workshop was to establish a roadmap to building an evidence base on that would indicate whether acupuncture is helpful for treating active-duty military personnel experiencing acute pain.
The workshop highlighted brief presentations on the most current research on acupuncture and acute pain mechanisms. The impact of various modifiers (stress, genetics, population, phenotypes, etc.) on acute pain pathways and response to acupuncture treatment was discussed.
Additional presentations focused on common neural mechanisms, an overview of real-world experience with using acupuncture to treat traumatic acute pain, and best tools and methods specific for acupuncture studies. Three breakout groups addressed the gaps, opportunities, and barriers to acupuncture use for acute pain in military and trauma settings. Different models of effectiveness research and optimal research designs for conducting trials in acute traumatic pain were also discussed.
C1 [Edwards, Emmeline; Glowa, John; Khalsa, Partap; Weber, Wendy; Huntley, Kristen] NCCAM, Div Extramural Res, Bethesda, MD 20892 USA.
[Belard, Jean Louis] USA, Henry M Jackson Fdn, Telemed & Adv Technol Res Ctr, MCMR TT,Med Res & Mat Command, Ft Detrick, MD USA.
RP Edwards, E (reprint author), NCCAM, Div Extramural Res, Courier Serv 20817, 6707 Democracy Blvd 2,Suite 401, Bethesda, MD 20892 USA.
EM edwardse@mail.nih.gov
NR 36
TC 1
Z9 2
U1 0
U2 6
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD MAR
PY 2013
VL 19
IS 3
BP 266
EP 279
DI 10.1089/acm.2012.9229.dod
PG 14
WC Integrative & Complementary Medicine
SC Integrative & Complementary Medicine
GA 110RW
UT WOS:000316464200014
PM 23020611
ER
PT J
AU Carlson, DW
Pearson, RD
Haggerty, PF
Strilka, RJ
Abella, BS
Gourley, PE
AF Carlson, Daniel W.
Pearson, Ryan D.
Haggerty, Paul F.
Strilka, Richard J.
Abella, Benjamin S.
Gourley, Paul E.
TI COMMOTIO CORDIS, THERAPEUTIC HYPOTHERMIA, AND EVACUATION FROM A UNITED
STATES MILITARY BASE IN IRAQ
SO JOURNAL OF EMERGENCY MEDICINE
LA English
DT Article
DE commotio cordis; cardiac arrest; therapeutic hypothermia;
cardiopulmonary resuscitation
ID CARDIAC-ARREST; TASK-FORCE; RESUSCITATION; TRAUMA; GUIDELINES;
COMMITTEE; ADULTS; DEATH
AB Background: Therapeutic hypothermia (TH) has been demonstrated to improve clinical outcomes after out-of-hospital ventricular fibrillation (VF) cardiac arrest. It remains unclear if TH can be safely and effectively used in the setting of traumatic arrest. Furthermore, the use of TH methods in the pre-hospital and transport environments remain poorly established and a domain of active investigation. Objectives: To describe a case of successful TH utilization after blunt trauma with commotio cordis and pulmonary contusion, and to describe the continuation of TH during international fixed-wing aeromedical transport. Case Report: A 33-year-old active duty soldier suffered blunt chest trauma and immediate VF arrest. He was successfully resuscitated with cardiopulmonary resuscitation and defibrillation attempts. Given his ensuing comatose post-arrest state, he was therapeutically cooled and subsequently evacuated from Iraq to Germany, with cooling maintenance established in flight without the availability of training or commercial cooling equipment. The patient exhibited an eventual excellent neurologic recovery. To utilize TH for this patient, military physicians with limited local resources employed a telemedical approach to obtain a hypothermia protocol to develop a successful treatment plan. Conclusions: The patient's successful resuscitation suggests that care should not be withheld for blunt trauma patients without vital signs in the field if VF is present, until the differential diagnosis of commotio cordis has been considered. (C) 2013 Elsevier Inc.
C1 [Carlson, Daniel W.] Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA.
[Pearson, Ryan D.] Dept Family Med, Travis AFB, CA USA.
[Haggerty, Paul F.] Dept Internal Med, Wright Patterson AFB, OH USA.
[Strilka, Richard J.] Royal AF Lakenheath, Brandon, Suffolk, England.
[Abella, Benjamin S.] Univ Penn, Ctr Resuscitat Sci, Philadelphia, PA 19104 USA.
[Gourley, Paul E.] Langley AFB, Hampton, VA USA.
RP Abella, BS (reprint author), Univ Penn, Ctr Resuscitat Sci, 3400 Spruce St, Philadelphia, PA 19104 USA.
OI Abella, Benjamin/0000-0003-2521-0891
FU Philips Healthcare
FX Dr. Abella has received honoraria from Medivance Corporation and
unrestricted research funding from Philips Healthcare. The other authors
declare no relevant disclosures.
NR 17
TC 2
Z9 2
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0736-4679
J9 J EMERG MED
JI J. Emerg. Med.
PD MAR
PY 2013
VL 44
IS 3
BP 620
EP 624
DI 10.1016/j.jemermed.2012.08.014
PG 5
WC Emergency Medicine
SC Emergency Medicine
GA 103VF
UT WOS:000315946900015
PM 23079150
ER
PT J
AU VanDeMark, TF
Johnson, LB
Pitarka, A
Bennett, HH
Simms, JE
Yule, DE
AF VanDeMark, Thomas F.
Johnson, Lars B.
Pitarka, Arben
Bennett, Hollis H., Jr.
Simms, Janet E.
Yule, Don E.
TI Evaluation of Seismic-Acoustic Analysis Methods for a Real-time UXO
Monitoring System
SO JOURNAL OF ENVIRONMENTAL AND ENGINEERING GEOPHYSICS
LA English
DT Article
AB The Department of Defense (DoD) uses over two million rounds of high-explosive (HE) munitions per year (Defense Science Board Task Force, 2003). A small percentage does not explode, thus generating unexploded ordnance (UXO) in current range areas at a substantial rate. As these ranges are closed, the DoD becomes responsible for the environmental restoration of the affected properties. Current methods of UXO remediation are costly because of high false alarm rates. Our current research is to develop a complementary technology that will alleviate false alarm rate by detecting, classifying, and locating UXO in near real time (less than 1 minute) as a munition impacts the range. This technology will utilize an array of buried seismic sensors in a calibrated range area, along with a set of algorithms based on theoretical and applied seismology and statistical analysis.
Initial field tests at three sites focused on developing concepts of the seismic and acoustic location of ordnance impacts. Our research program developed from these initial field tests has four primary objectives: 1) fully implement a wired seismic-acoustic ordnance impact location system for live fire ranges; 2) develop a system capability to discriminate high-order (HE), low-order (partially exploded), and zero-order (UXO) events; 3) reduce location error to a stringent program metric of 1-2 m; and 4) investigate the feasibility of developing a wireless implementation of the technology.
This paper describes the procedures and results from follow-on tests that were conducted in two locations at the U.S. Army Aberdeen Proving Ground (APG), Maryland. These tests were used to evaluate potential seismic-acoustic methods and system configurations for a Seismic-Acoustic Impact Monitoring Assessment (SAIMA) system for mitigating UXO hazards. Significant results from this work include: 1) seismic impulses from low-order impacts were detected at distances up to 1,000 meters; 2) classification features based on measurements of the amplitude of acoustic and seismic phases produce clear discrimination between HE and UXO impacts; 3) calculated location solutions for HE and UXO impacts yield an average location error of 10-20 meters; and 4) empirical observation and waveform modeling demonstrated that surface waves dominate the signal at all distances and therefore should be the primary phase used for all components of analysis. Furthermore, these tests demonstrated the current system design, allowing further enhancements, is capable of meeting the initial research objectives (1) and (2). Future research will focus on improving system performance with refinement of the sensor-layout geometry and the detection and location algorithms through system error analyses and follow-on field testing.
C1 [VanDeMark, Thomas F.; Johnson, Lars B.; Pitarka, Arben] Quantum Technol Sci Inc, Cocoa Beach, FL 32931 USA.
[Bennett, Hollis H., Jr.; Simms, Janet E.; Yule, Don E.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP VanDeMark, TF (reprint author), USAF, Tech Applicat Ctr, 1030 S Highway A1A,Bldg 989, Patrick AFB, FL 32925 USA.
RI pitarka, arben/K-5491-2014
NR 16
TC 1
Z9 1
U1 0
U2 10
PU ENVIRONMENTAL ENGINEERING GEOPHYSICAL SOC
PI DENVER
PA 1720 SOUTH BELLAIRE, STE 110, DENVER, CO 80222-433 USA
SN 1083-1363
J9 J ENVIRON ENG GEOPH
JI J. Environ. Eng. Geophys.
PD MAR
PY 2013
VL 18
IS 1
BP 71
EP 85
DI 10.2113/JEEG18.1.71
PG 15
WC Geochemistry & Geophysics; Engineering, Geological
SC Geochemistry & Geophysics; Engineering
GA 106RZ
UT WOS:000316163700005
ER
PT J
AU Samberg, ME
Tan, Z
Monteiro-Riviere, NA
Orndorff, PE
Shirwaiker, RA
AF Samberg, Meghan E.
Tan, Zhuo
Monteiro-Riviere, Nancy A.
Orndorff, Paul E.
Shirwaiker, Rohan A.
TI Biocompatibility analysis of an electrically-activated silver-based
antibacterial surface system for medical device applications
SO JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
LA English
DT Article
ID NANOPARTICLES; INFECTION; TOXICITY; METALS; CELLS
AB The costs associated with the treatment of medical device and surgical site infections are a major cause of concern in the global healthcare system. To prevent transmission of such infections, a prophylactic surface system that provides protracted release of antibacterial silver ions using low intensity direct electric current (LIDC; 28 mu A system current at 6 V) activation has been recently developed. To ensure the safety for future in vivo studies and potential clinical applications, this study assessed the biocompatibility of the LIDC-activated interdigitated silver electrodes-based surface system; in vitro toxicity to human epidermal keratinocytes, human dermal fibroblasts, and normal human osteoblasts, and antibacterial efficacy against Staphylococcus aureus and Escherichia coli was evaluated. The study concluded that the technological applications of the surface system for medical devices and surgical tools, which contact human tissues for less than 1.5 h, are expected to be self-sterilizing without causing toxicity in vivo.
C1 [Samberg, Meghan E.; Monteiro-Riviere, Nancy A.] N Carolina State Univ, Ctr Chem Toxicol Res & Pharmacokinet, Raleigh, NC 27607 USA.
[Samberg, Meghan E.; Tan, Zhuo; Shirwaiker, Rohan A.] Edward P Fitts Dept Ind Syst & Engn, Raleigh, NC 27695 USA.
[Samberg, Meghan E.; Monteiro-Riviere, Nancy A.; Shirwaiker, Rohan A.] N Carolina State Univ, Joint Dept Biomed Engn, Raleigh, NC 27607 USA.
[Samberg, Meghan E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Monteiro-Riviere, Nancy A.] Kansas State Univ, Dept Anat & Physiol, Manhattan, KS 66506 USA.
[Orndorff, Paul E.] N Carolina State Univ, Dept Populat Hlth & Pathobiol, Raleigh, NC 27607 USA.
RP Shirwaiker, RA (reprint author), Edward P Fitts Dept Ind Syst & Engn, 400 Daniels Hall, Raleigh, NC 27695 USA.
EM rashirwaiker@ncsu.edu
FU ArgentumCidalElectrics, Inc., Pittsburgh, PA; North Carolina State
University's Research and Innovation Seeding Funding (RISF) Program
FX The cytotoxicity evaluation experiments were supported by a research
Grant from ArgentumCidalElectrics, Inc., Pittsburgh, PA. The
antimicrobial efficacy testing experiments were supported by a research
Grant from North Carolina State University's Research and Innovation
Seeding Funding (RISF) Program.
NR 23
TC 9
Z9 9
U1 0
U2 16
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0957-4530
J9 J MATER SCI-MATER M
JI J. Mater. Sci.-Mater. Med.
PD MAR
PY 2013
VL 24
IS 3
BP 755
EP 760
DI 10.1007/s10856-012-4838-5
PG 6
WC Engineering, Biomedical; Materials Science, Biomaterials
SC Engineering; Materials Science
GA 104TR
UT WOS:000316018700018
PM 23242768
ER
PT J
AU Closmann, JJ
Eliot, CA
Foss, RD
AF Closmann, James J.
Eliot, Colin A.
Foss, Robert D.
TI Ectomesenchymal Chondromyxoid Tumor: Report of a Case With Description
of Histologic and Immunohistochemical Findings
SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
LA English
DT Article
ID ANTERIOR TONGUE
C1 [Closmann, James J.] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
[Eliot, Colin A.] Joint Base Pearl Harbor Hickam, Joint POW MIA Accounting Command, Cent Identificat Lab, Honolulu, HI USA.
[Foss, Robert D.] USN, Dept Oral & Maxillofacial Pathol, Sch Postgrad Dent, Rockville, MD USA.
RP Closmann, JJ (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM armyjawbreaker@gmail.com
NR 14
TC 2
Z9 2
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0278-2391
J9 J ORAL MAXIL SURG
JI J. Oral Maxillofac. Surg.
PD MAR
PY 2013
VL 71
IS 3
BP 545
EP 549
DI 10.1016/j.joms.2012.08.003
PG 5
WC Dentistry, Oral Surgery & Medicine
SC Dentistry, Oral Surgery & Medicine
GA 107YM
UT WOS:000316256900015
PM 23043966
ER
PT J
AU Martini, WZ
Dubick, MA
Blackbourne, LH
AF Martini, Wenjun Z.
Dubick, Michael A.
Blackbourne, Lorne H.
TI Comparisons of lactated Ringer's and Hextend resuscitation on
hemodynamics and coagulation following femur injury and severe
hemorrhage in pigs
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article; Proceedings Paper
CT 71st Annual Meeting of the
American-Association-for-the-Surgery-of-Trauma
CY SEP 12-15, 2012
CL Kauai, HI
SP Amer Assoc Surg Trauma
DE Hemorrhagic shock; Hextend; lactated Ringer's (LR) solution;
thrombelastography; pig
ID CARDIAC-SURGERY PATIENTS; NATURAL COLLOID RESUSCITATION; HYDROXYETHYL
STARCH 130/0.4; SEVERE LIVER-INJURY; FLUID RESUSCITATION; ATTENUATES
HYPERCOAGULABILITY; DILUTIONAL COAGULOPATHY; INCREASING HEMORRHAGE;
REPLACEMENT THERAPY; BLOOD-COAGULATION
AB BACKGROUND: This study compared coagulation function after resuscitation with Hextend and lactated Ringer's (LR) solution in pigs with tissue injury and hemorrhagic shock.
METHODS: Pigs were randomized into control (n = 7 each), LR, and Hextend groups. Femur fracture was induced using the captive bolt stunner at midshaft of the pigs' left legs, followed by hemorrhage of 60% total blood volume and resuscitation with either Hextend (equal to bled volume) or LR to reach the same mean arterial pressure. Pigs in the control group were not bled or resuscitated. Hemodynamics was monitored hourly for 6 hours. Blood samples were taken at baseline (BL), after hemorrhage, 15 minutes, 3 hours, and 6 hours after resuscitation for blood and coagulation measurements.
RESULTS: Mean arterial pressure decreased to 50% of BL by the 60% hemorrhage but returned to near BL within 1 hour after LR or Hextend resuscitation. Heart rate was increased (from 91 +/- 4 beats per minute to 214 +/- 20 beats per minute) by hemorrhage and decreased after resuscitation but remained elevated above BL in both groups. Resuscitation with Hextend (42 mL/kg) or LR (118 +/- 3 mL/kg) reduced hematocrit, total protein, fibrinogen, and platelet counts, with greater decreases shown in the Hextend group. Clot strengthwas lower but returned to BL by 3 hours in the LR group, whereas it remained reduced for the 6-hour period after Hextend. The overall clotting capacity after LR was decreased after hemorrhage and resuscitation but returned to BL by 3 hours, whereas it remained low after Hextend for the 6-hour experiment period.
CONCLUSION: After traumatic hemorrhage, coagulation function was restored within 6 hours with LR resuscitation but not with Hextend. The lack of recovery after Hextend is likely caused by greater hemodilution and possible effects of starches on coagulation substrates and further documents the need to restrict the use of high-molecular-weight starch in resuscitation fluids for bleeding casualties. (J Trauma Acute Care Surg. 2013; 74: 732-740. Copyright (C) 2013 by Lippincott Williams & Wilkins)
C1 [Martini, Wenjun Z.; Dubick, Michael A.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Martini, WZ (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM wenjun.martini@amedd.army.mil
NR 42
TC 10
Z9 10
U1 2
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 2163-0755
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD MAR
PY 2013
VL 74
IS 3
BP 732
EP 739
PG 8
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA 108UO
UT WOS:000316321900006
PM 23425729
ER
PT J
AU Greer, LT
Kuehn, RB
Gillespie, DL
White, PW
Bell, RS
Armonda, RA
Fox, CJ
AF Greer, Lauren T.
Kuehn, Reed B.
Gillespie, David L.
White, Paul W.
Bell, Randy S.
Armonda, Rocco A.
Fox, Charles J.
TI Contemporary management of combat-related vertebral artery injuries
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article
DE Vascular trauma; management; vertebral artery; combat; military trauma
ID BLUNT CEREBROVASCULAR INJURIES; COMPUTED TOMOGRAPHIC ANGIOGRAPHY;
ENDOVASCULAR MANAGEMENT; ARTERIOVENOUS-FISTULAS; TRAUMATIC ANEURYSMS;
VASCULAR INJURY; NECK TRAUMA; DIAGNOSIS; OUTCOMES; ASSOCIATION
AB BACKGROUND: Vertebral artery injuries (VAIs) following cervical trauma are uncommon. Advances in imaging technology and emerging endovascular therapies have allowed for the improved diagnosis and treatment of VAIs. We aimed to examine the contemporary management of combat-related penetrating VAIs during current US military operations.
METHODS: A retrospective review was performed on US casualties with combat-related VAIs evacuated to a single military institution in the US from September 2001 to 2010 for definitive management. Casualty demographics, mechanism of injury, location and type of VAI, neurologic sequela, associated injuries, method of diagnosis, and therapeutic management were collected.
RESULTS: Eleven casualties with a mean age of 26 years (mean [SD] ISS, 18 [7.0]) were found to have VAIs from gunshot wounds (6, 55%) or blast fragments (5, 45%). Cervical spine fractures (8, 72%), facial fractures (5, 45%), and spinal cord injury (3, 27%) were not uncommon. One casualty experienced a posterior cerebellar and parietal infarcts. All injuries were evaluated with digital subtraction angiography, 64-slice multidetector row computed tomography, or both. Casualties were noted to have vertebral artery occlusion (4, 36%), pseudoaneurysms (5, 45%), dissection (1, 9%), or arteriovenous fistula (1, 9%), with most injuries occurring in the V2 segment (6, 55%). Pseudoaneurysms were treated with coiling or stent-assisted coiling. Of 11 casualties, 6 were managed nonoperatively, half of whom with anticoagulation or antiplatelet therapy.
CONCLUSION: VAIs are infrequent in modern combat operations, occurring in only 3% of casualties experiencing arterial injuries and are often incidentally discovered during the delayed secondary evaluation of penetrating face and neck injuries at higher echelons of care. One should have a high index of suspicious for a VAI in a casualty with concurrent cervical spine fractures. Endovascular therapies using coils and covered stents have expanded the management options and simplified the treatment of combat-related VAIs. (J Trauma Acute Care Surg. 2013;74: 818-824. Copyright (c) 2013 by Lippincott Williams & Wilkins)
C1 [Greer, Lauren T.] Walter Reed Natl Mil Med Ctr, Gen Surg Serv, Bethesda, MD 20889 USA.
[Bell, Randy S.; Armonda, Rocco A.] Walter Reed Natl Mil Med Ctr, Neurosurg Serv, Bethesda, MD 20889 USA.
[Fox, Charles J.] Walter Reed Natl Mil Med Ctr, Vasc Surg Serv, Dept Surg, Bethesda, MD 20889 USA.
[Fox, Charles J.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Div Vasc Surg, Bethesda, MD 20814 USA.
[Kuehn, Reed B.] Womack Army Med Ctr, Dept Surg, Ft Bragg, NC USA.
[Gillespie, David L.] Univ Rochester, Div Vasc Surg, Rochester, NY USA.
[White, Paul W.] Eisenhower Army Med Ctr, Dept Vasc Surg, Augusta, GA USA.
RP Fox, CJ (reprint author), Walter Reed Natl Mil Med Ctr, Div Vasc Surg, 8901 Rockville Pike, Bethesda, MD 20889 USA.
EM Foxvascular@gmail.com
OI Gillespie, David/0000-0002-4378-9465
FU New York Institute for Vascular Studies
FX This work was supported by Dr. Frank J. Veith, MD and a grant from the
New York Institute for Vascular Studies to honor military surgery and
support the Walter Reed Vascular Registry.
NR 40
TC 3
Z9 5
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 2163-0755
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD MAR
PY 2013
VL 74
IS 3
BP 818
EP 824
DI 10.1097/TA.0b013e31827a08a8
PG 7
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA 108UO
UT WOS:000316321900023
PM 23425741
ER
PT J
AU Morrison, JJ
Poon, H
Rasmussen, TE
Khan, MA
Midwinter, MJ
Blackbourne, LH
Garner, JP
AF Morrison, Jonathan J.
Poon, Henrietta
Rasmussen, Todd E.
Khan, Mansoor A.
Midwinter, Mark J.
Blackbourne, Lorne H.
Garner, Jeffery P.
TI Resuscitative thoracotomy following wartime injury
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article; Proceedings Paper
CT 71st Annual Meeting of the
American-Association-for-the-Surgery-of-Trauma
CY SEP 12-15, 2012
CL Kauai, HI
SP Amer Assoc Surg Trauma
DE Resuscitative thoracotomy; war surgery; trauma surgery; damage-control
surgery
ID EMERGENCY-DEPARTMENT THORACOTOMY; TRAUMA CENTER; MORTALITY; OUTCOMES;
SCORE
AB BACKGROUND: The evidence for resuscitative thoracotomy (RT) in trauma patients following wartime injury is limited; its indications and timings are less defined in battle injury. The aim of this study was to analyze survival as well as the causes and times of death in patients undergoing RT within the context of modern battlefield resuscitation.
METHODS: A retrospective cohort study was performed on consecutive admissions to a Field Hospital in Southern Afghanistan. All patients undergoing RT were identified using the UK Joint Theatre Trauma Registry. The primary outcome was 30-day mortality, and secondary outcomes included location of cardiac arrest, time from arrest to thoracotomy, and proportion achieving a return of spontaneous circulation.
RESULTS: Between April 2006 to March 2011, 65 patients underwent RT with 14 survivors (21.5%). Ten patients (15.4%) had an arrest in the field with no survivors, 29 (44.6%) had an arrest en route with 3 survivors, and 26 (40.0%) had an arrest in the emergency department with 11 survivors. There was no difference in Injury Severity Scores (ISSs) between survivors and fatalities (27.3 [7.6] vs. 36.0 [22.1], p = 0.636). Survivors had a significantly shorter time to thoracotomy than did fatalities (6.15 [5.8] minutes vs. 17.7 [12.63] minutes, p < 0.001).
CONCLUSION: RT following combat injury will yield survivors. Best outcomes are in patients who have an arrest in the emergency department or on admission to the hospital. (J Trauma Acute Care Surg. 2013;74: 825-829. Copyright (c) 2013 by Lippincott Williams & Wilkins)
C1 [Morrison, Jonathan J.; Poon, Henrietta; Rasmussen, Todd E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Khan, Mansoor A.] Univ Maryland, R Adams Cowley Shock Trauma Ctr, Baltimore, MD 21201 USA.
[Morrison, Jonathan J.; Khan, Mansoor A.; Midwinter, Mark J.] Royal Ctr Def Med, Dept Mil Surg & Trauma, Birmingham, W Midlands, England.
[Garner, Jeffery P.] Rotterham NHS Fdn Trust, Rotterham, England.
RP Morrison, JJ (reprint author), Joint Med Command, Acad Dept Mil Surg & Trauma, Royal Ctr Def Med, Vincent Dr, Birmingham B15 2SQ, AL, England.
EM jjmorrison@outlook.com
RI Midwinter, Mark/P-6264-2015;
OI Midwinter, Mark/0000-0003-1836-7137; Morrison,
Jonathan/0000-0001-7462-8456
NR 28
TC 16
Z9 17
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 2163-0755
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD MAR
PY 2013
VL 74
IS 3
BP 825
EP 829
DI 10.1097/TA.0b013e31827e1d26
PG 5
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA 108UO
UT WOS:000316321900024
PM 23425742
ER
PT J
AU Stannard, A
Morrison, JJ
Scott, DJ
Ivatury, RA
Ross, JD
Rasmussen, TE
AF Stannard, Adam
Morrison, Jonathan J.
Scott, Daniel J.
Ivatury, Rebecca A.
Ross, James D.
Rasmussen, Todd E.
TI The epidemiology of noncompressible torso hemorrhage in the wars in Iraq
and Afghanistan
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article; Proceedings Paper
CT 71st Annual Meeting of the
American-Association-for-the-Surgery-of-Trauma
CY SEP 12-15, 2012
CL Kauai, HI
SP Amer Assoc Surg Trauma
DE Wartime injury; noncompressible torso hemorrhage; vascular trauma
ID COMBAT CASUALTY CARE; MAJOR LIMB TRAUMA; INJURY; MANAGEMENT; DEATH;
BATTLEFIELD; MORTALITY; US
AB BACKGROUND: Noncompressible torso hemorrhage (NCTH) is the leading cause of potentially survivable trauma in the battlefield and has recently been defined using anatomic and physiologic criteria. The objective of this study was to characterize the frequency and mortality in combat of NCTH using a contemporary definition.
METHODS: Four categories of torso injury, each based on vascular disruption, were identified in US military casualties from the Department of Defense Trauma Registry (2002-2010): (1) thoracic, including lung; (2) solid organ (high-grade spleen, liver, and kidney); (3) named axial vessel; and (4) pelvic fracture with ring disruption. Injuries within these categories were evaluated in the context of physiologic indicator of shock and/or the need for operative hemorrhage control.
RESULTS: Of 15,209 battle injuries sustained during the study period, 12.7% (n = 1,936) had sustained one or more categories of torso injury. Of these, 331 (17.1%) had evidence of shock or the need for urgent hemorrhage control, with a mean (SD) Injury Severity Score (ISS) and mortality rate of 30 (13) and 18.7%, respectively. Pulmonary injuries were most numerous (41.7%), followed by solid-organ (29.3%), vascular (25.7%), and pelvic (15.1%) injuries. Following multivariate analysis, the most mortal injury complexes were identified as major arterial injury (odds ratio, 3.38; 95% confidence interval, 1.17-9.74) and pulmonary injury (odds ratio, 2.23; 95% confidence interval, 1.23-4.98).
CONCLUSION: NCTH can be defined using anatomic parameters combined with physiologic and operative interventions suggestive of hemorrhage. Major arterial and pulmonary injuries contribute most significantly to the mortality burden. (J Trauma Acute Care Surg. 2013;74: 830-834. Copyright (c) 2013 by Lippincott Williams & Wilkins)
C1 [Stannard, Adam; Morrison, Jonathan J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England.
[Morrison, Jonathan J.; Scott, Daniel J.; Ivatury, Rebecca A.; Rasmussen, Todd E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Scott, Daniel J.; Ross, James D.; Rasmussen, Todd E.] Lackland AFB, Sci & Technol Sect, San Antonio, TX USA.
[Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA.
RP Rasmussen, TE (reprint author), USA, Inst Surg Res, San Antonio, TX 78234 USA.
EM todd.rasmussen@amedd.army.mil
OI Morrison, Jonathan/0000-0001-7462-8456
NR 20
TC 28
Z9 29
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 2163-0755
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD MAR
PY 2013
VL 74
IS 3
BP 830
EP 834
DI 10.1097/TA.0b013e31827a3704
PG 5
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA 108UO
UT WOS:000316321900025
PM 23425743
ER
PT J
AU Gerlach, RC
Dixon, DR
Goksel, T
Castle, JT
Henry, WA
AF Gerlach, Robert C.
Dixon, Douglas R.
Goksel, Tamer
Castle, James T.
Henry, Walter A.
TI Case presentation of florid cemento-osseous dysplasia with concomitant
cemento-ossifying fibroma discovered during implant explantation
SO ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
LA English
DT Article
ID SIMPLE BONE-CYST; JAWS; FEATURES
AB A 39-year-old African American woman presented for treatment of a symptomatic mandibular right first molar with a large, periapical radiolucency. After initial attempts at endodontic therapy, this tooth was ultimately extracted owing to unabated symptoms. The extraction site underwent ridge preservation grafting, implant placement, and restoration. After 26 months of implant function, the patient returned with clinical symptoms of pain, buccal swelling, and the sensation of a "loose" implant. This case report details a diagnosis of 2 distinct disease entities associated with the implant site, a cemento-ossifying fibroma and florid cemento-osseous dysplasia of the mandible. This diagnosis was determined from clinical, surgical, radiographic, and histopathologic evidence after biopsy and removal of the previously osseointegrated implant following postinsertion failure by fibrous encapsulation. Before implant therapy, it is essential to conduct a thorough radiographic evaluation of any dental arch with suspected bony lesions to prevent implant failure. (Oral Surg Oral Med Oral Pathol Oral Radiol 2013;115:e44-e52)
C1 [Gerlach, Robert C.] USA, Adv Educ Program Periodont, Ft Gordon, GA 30905 USA.
[Gerlach, Robert C.] USA, Adv Educ Program Oral Surg, Ft Gordon, GA 30905 USA.
[Gerlach, Robert C.] USA, Adv Educ Program Oral Pathol, Ft Gordon, GA 30905 USA.
[Goksel, Tamer] Oral & Maxillofacial Surg Residency Program, Ft Gordon, GA USA.
[Henry, Walter A.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA.
RP Gerlach, RC (reprint author), USA, Adv Educ Program Periodont, Tingay Dent Clin, Bldg 278,320 E Hosp St, Ft Gordon, GA 30905 USA.
EM robert.campbell.gerlach@us.army.mil
NR 28
TC 2
Z9 2
U1 0
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 2212-4403
J9 OR SURG OR MED OR PA
JI Oral Surg. Oral Med. Oral Pathol. Oral Radiol.
PD MAR
PY 2013
VL 115
IS 3
BP E44
EP E52
DI 10.1016/j.oooo.2012.05.020
PG 9
WC Dentistry, Oral Surgery & Medicine
SC Dentistry, Oral Surgery & Medicine
GA 109DJ
UT WOS:000316345500008
PM 22858018
ER
PT J
AU Maynard, EE
Brewer, JS
AF Maynard, Erynn E.
Brewer, J. Stephen
TI Restoring Perennial Warm-Season Grasses as a Means of Reversing
Mesophication of Oak Woodlands in Northern Mississippi
SO RESTORATION ECOLOGY
LA English
DT Article
DE Andropogon virginicus; fire; leaf litter; Schizachyrium scoparium;
thinning
ID PRESCRIBED FIRE; UPLAND FORESTS; REGENERATION; RESTORATION; STANDS;
SITES
AB Fire suppression has removed an important ecological force previously responsible for shaping many plant communities throughout the world. Upland areas of north-central Mississippi that have been protected from fire are now closed-canopy forests including species known to be uncommon as bearing/witness trees in upland portions of the landscape (historically off-site species) and sparse ground cover vegetation. Anecdotal evidence suggests that warm-season grasses were prevalent in the understory of these communities, which could have provided more consistent fuel. We corroborate the historic presence of these grasses by looking at their natural co-occurrence with oak regeneration (a requisite of self-replacing stands of oaks found historically). Restoration of these communities has typically focused on burning and off-site tree thinning. Utilizing a restoration experiment implementing these treatments, we found significantly reduced understory leaf litter in treatment areas. To test which variables associated with restoration treatments were most important for the survival of these grasses, we measured the effect of leaf litter removal and its interaction with environmental conditions on the survival of transplanted shoots. Survival of little bluestem increased with decreasing canopy density and decreasing leaf litter. Leaf-litter removal did not increase survival, nor did it interact with either pre-treatment leaf litter depth or canopy density. These results show that little bluestem benefits from conditions expected historically: increased light and possibly fire.
C1 [Maynard, Erynn E.] USACE ERDC Environm Lab, Vicksburg, MS 39180 USA.
[Brewer, J. Stephen] Univ Mississippi, Dept Biol, University, MS 38677 USA.
RP Brewer, JS (reprint author), Univ Mississippi, Dept Biol, POB 1848, University, MS 38677 USA.
EM jbrewer@olemiss.edu
RI Clark, Stacy/I-3410-2015
FU U.S.D.A. Food and Agricultural Sciences National Needs Graduate and
Postdoctoral Fellowship Grants Program; National Audubon Society, Inc.,;
Sigma Xi Grants-in-Aid of Research Program
FX The authors thank the first author's graduate thesis committee, J.
Hoeksema and D. Reed, for their comments. Support was from a U.S.D.A.
Food and Agricultural Sciences National Needs Graduate and Postdoctoral
Fellowship Grants Program. We also received funding from the National
Audubon Society, Inc., and the Sigma Xi Grants-in-Aid of Research
Program.
NR 34
TC 0
Z9 0
U1 3
U2 21
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1061-2971
J9 RESTOR ECOL
JI Restor. Ecol.
PD MAR
PY 2013
VL 21
IS 2
BP 242
EP 249
DI 10.1111/j.1526-100X.2012.00871.x
PG 8
WC Ecology
SC Environmental Sciences & Ecology
GA 105MN
UT WOS:000316075000017
ER
PT J
AU Bruscino, T
AF Bruscino, Thomas
TI State of War: The Political Economy of American Warfare, 1945-2011
SO SOCIAL SCIENCE JOURNAL
LA English
DT Book Review
C1 [Bruscino, Thomas] USA, Sch Adv Mil Studies, Ft Leavenworth, KS USA.
RP Bruscino, T (reprint author), USA, Sch Adv Mil Studies, Ft Leavenworth, KS USA.
EM tom.bruscino@gmail.com
NR 1
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0362-3319
J9 SOC SCI J
JI Soc. Sci. J.
PD MAR
PY 2013
VL 50
IS 1
BP 129
EP 130
DI 10.1016/j.soscij.2013.01.001
PG 2
WC Social Sciences, Interdisciplinary
SC Social Sciences - Other Topics
GA 110EL
UT WOS:000316425300015
ER
PT J
AU Jensen, P
Roman, J
Shaft, B
Wrisberg, C
AF Jensen, Peter
Roman, Jorge
Shaft, Barrett
Wrisberg, Craig
TI In the Cage: MMA Fighters' Experience of Competition
SO SPORT PSYCHOLOGIST
LA English
DT Article
ID MIXED MARTIAL ARTS; TAE-KWON-DO; SELF-CONFIDENCE; SPORT; PERFORMANCE;
ANXIETY; STRESS; PERCEPTIONS; PSYCHOLOGY; INJURY
AB Mixed Martial Arts (MMA) is a relatively new and rapidly growing sport within contemporary athletics yet, to date, it has received relatively little attention in the sport psychology literature. To shed more light on the sport, the aim of the current study was to examine the experiences of MMA fighters during sanctioned competitions. Audio-recorded phenomenological interviews were conducted with seven participants and the transcripts were qualitatively analyzed to identify emerging themes. The findings revealed that the most important aspect of fighters' experience was the chaotic nature of MMA fights, which participants characterized as "cage reality." The results also suggested that fighters' arousal regulation skills are at least as important as their technical skills for performance success. Taken together, the present findings extend previous research on MMA and suggest several implications for sport psychology consultants interested in working with fighters.
C1 [Jensen, Peter; Roman, Jorge; Shaft, Barrett; Wrisberg, Craig] Univ Tennessee, Dept Kinesiol Recreat & Sport Studies, Knoxville, TN USA.
RP Jensen, P (reprint author), US Mil Acad, Ctr Enhanced Performance, West Point, NY 10996 USA.
NR 48
TC 7
Z9 8
U1 2
U2 28
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 0888-4781
J9 SPORT PSYCHOL
JI Sport Psychol.
PD MAR
PY 2013
VL 27
IS 1
BP 1
EP 12
PG 12
WC Hospitality, Leisure, Sport & Tourism; Psychology, Applied; Psychology;
Sport Sciences
SC Social Sciences - Other Topics; Psychology; Sport Sciences
GA 111QR
UT WOS:000316536300002
ER
PT J
AU O'Connell, RJ
Gates, RG
Bautista, CT
Imbach, M
Eggleston, JC
Beardsley, SG
Manak, MM
Gonzales, R
Rentas, FJ
Macdonald, VW
Cardo, LJ
Reiber, DT
Stramer, SL
Michael, NL
Peel, SA
AF O'Connell, Robert J.
Gates, Robert G.
Bautista, Christian T.
Imbach, Michelle
Eggleston, John C.
Beardsley, Stephen G.
Manak, Mark M.
Gonzales, Richard
Rentas, Francisco J.
Macdonald, Victor W.
Cardo, Lisa J.
Reiber, David T.
Stramer, Susan L.
Michael, Nelson L.
Peel, Sheila A.
TI Laboratory evaluation of rapid test kits to detect hepatitis C antibody
for use in predonation screening in emergency settings
SO TRANSFUSION
LA English
DT Article
ID FRESH WHOLE-BLOOD; HUMAN-IMMUNODEFICIENCY-VIRUS; OPERATION ENDURING
FREEDOM; UNITED-STATES; RESIDUAL RISK; IRAQI FREEDOM; TRANSFUSION;
MILITARY; INFECTIONS; PREVALENCE
AB BACKGROUND: Emergency whole blood transfusion is a lifesaving procedure employed on modern battlefields. Rapid device tests (RDTs) are frequently used to mitigate transfusion-transmitted infection risks. STUDY DESIGN AND METHODS: A limited evaluation of the RDT formerly used on battlefields was performed using 50 donor plasma samples and commercially available panels. Five hepatitisC virus (HCV) RDTs with sufficient stated sensitivity and thermostability were assessed using 335 HCV-positive and 339 HCV-negative donor plasma samples, 54 seroconversion panel plasma samples, and 84 HCV-positive and 84 HCV-negative spiked whole blood under normal, hot, and cold storage conditions and normal and hot test conditions, plus an ease-of-use survey. RESULTS: BioRapid HCV test sensitivity on donor plasma was 84% (95% confidence interval [CI], 70.9%-92.8%). Using all positive plasma samples, OraQuick HCV sensitivity exceeded all comparators (99.4%, 95% CI, 98.0%-99.9%, p<0.05). Specificity was consistently high, led by OraQuick HCV at 99.7% (95% CI, 98.6%-100%), statistically superior only to Axiom HCV (p<0.05). Using seroconversion panels, only OraQuick HCV showed equivalent or earlier HCV detection compared to the gold standard. Using spiked whole blood, specificity was consistently high, and sensitivity ranged significantly from 34.5% (95% CI, 25.0%-45.1%) for CORE HCV to 98.8% (95% CI, 94.3%-99.9%) for OraQuick HCV. All comparator RDTs were significantly less sensitive than OraQuick HCV at one or more stress condition. CONCLUSION: This HCV RDT comparison identified significant sensitivity differences, particularly using whole blood under extreme storage and testing conditions. These data support OraQuick HCV superiority and illustrate the value of RDT evaluation under simulated field conditions.
C1 Walter Reed Army Inst Res, Silver Spring, MD USA.
US Mil HIV Res Program, Ft Gordon, GA USA.
US Army Blood Program, Falls Church, VA USA.
US Army Med Dept Ctr & Sch, San Antonio, TX USA.
US Armed Serv Blood Program, Falls Church, VA USA.
Robertson Blood Ctr, Dept Blood Res, Ft Hood, TX USA.
Amer Red Cross, Gaithersburg, MD USA.
RP O'Connell, RJ (reprint author), Walter Reed Army Inst Res, Mil HIV Res Program, 6720-A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA.
EM roconnell@hivresearch.org
OI Manak, Mark /0000-0002-9217-9129
FU US Army Blood Program; Henry Jackson Foundation for the Advancement of
Military Medicine in collaboration [W81XWH-07-2-0067]; US Army
[W81XWH-07-2-0067]
FX This work was supported in part by funding from the US Army Blood
Program and by Cooperative Agreement W81XWH-07-2-0067 between the Henry
Jackson Foundation for the Advancement of Military Medicine in
collaboration and the US Army.
NR 41
TC 12
Z9 12
U1 0
U2 11
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0041-1132
J9 TRANSFUSION
JI Transfusion
PD MAR
PY 2013
VL 53
IS 3
BP 505
EP 517
DI 10.1111/j.1537-2995.2012.03770.x
PG 13
WC Hematology
SC Hematology
GA 104DF
UT WOS:000315969500008
PM 22823283
ER
PT J
AU Strandenes, G
Skogrand, H
Spinella, PC
Hervig, T
Rein, EB
AF Strandenes, Geir
Skogrand, Hakon
Spinella, Philip C.
Hervig, Tor
Rein, Erling B.
TI Donor performance of combat readiness skills of special forces soldiers
are maintained immediately after whole blood donation A study to support
the development of a prehospital fresh whole blood transfusion program
SO TRANSFUSION
LA English
DT Article
ID INTENSITY CYCLE EXERCISE; MASSIVE TRANSFUSION; TRAUMA PATIENTS; CASUALTY
CARE; COAGULOPATHY; SURVIVAL; INJURIES; KINETICS; IMPACT
AB BACKGROUND: Bleeding is a major cause of death in combat settings, and combat casualties in shock may benefit from fresh whole blood (FWB) transfusion. Buddy transfusion is a well-known lifesaving intervention, but little is known about donor combat safety aspects immediately after blood donation. The objectives of this study were to explore the effects of donation of 1unit of blood on physical and combat-related performance among active duty soldiers. We also investigated the feasibility of a short training program to teach nonmedics buddy transfusion. STUDY DESIGN AND METHODS: Twenty-five fit male soldiers from a special forces unit were divided into three groups and tested on 1) a Bruce protocol treadmill stress test, push-ups, and pull-ups; 2) a 50-round rapid pistol shooting test; and 3) an uphill hiking exercise carrying a 20-kg backpack. After baseline testing, the soldiers performed the tests again (2-6min) after donating 450mL of blood. The training program included blood collection and reinfusion procedures and we measured success rate of venipuncture, time for blood collection, and success in placing sternal intraosseous needle and reinfusing 1 unit of autologous blood. RESULTS: We did not find any significant decrease in performance either in physical or in shooting performance after donating blood. Nonmedic soldiers had a 100% success rate in blood collection and also infusion on fellow soldiers after a short introduction to the procedures. CONCLUSION: This study supports the fact that buddy transfusion may be feasible for healthy well-trained soldiers and does not decrease donor combat performance under ideal circumstances.
C1 [Strandenes, Geir] Norwegian Naval Special Operat Commando, N-5886 Bergen, Norway.
Washington Univ, Dept Pediat, Div Crit Care, St Louis, MO 63130 USA.
USA, Inst Surg Res, San Antonio, TX USA.
Univ Bergen, Dept Immunol & Transfus Med, Haukeland Univ Hosp, Bergen, Norway.
Univ Bergen, Gade Inst, Bergen, Norway.
Univ Oslo, Inst Basic Med Sci, Dept Physiol, Oslo, Norway.
Norwegian Army Special Operat Commando, Rena, Norway.
RP Strandenes, G (reprint author), Norwegian Naval Special Operat Commando, Postboks 1 Haakonsvern, N-5886 Bergen, Norway.
EM geir@docfish.no
NR 19
TC 14
Z9 14
U1 1
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0041-1132
J9 TRANSFUSION
JI Transfusion
PD MAR
PY 2013
VL 53
IS 3
BP 526
EP 530
DI 10.1111/j.1537-2995.2012.03767.x
PG 5
WC Hematology
SC Hematology
GA 104DF
UT WOS:000315969500010
PM 22738468
ER
PT J
AU Christova, I
Younan, R
Taseva, E
Gladnishka, T
Trifonova, I
Ivanova, V
Spik, K
Schmaljohn, C
Mohareb, E
AF Christova, Iva
Younan, Rasha
Taseva, Evgenia
Gladnishka, Teodora
Trifonova, Iva
Ivanova, Vladislava
Spik, Kristin
Schmaljohn, Connie
Mohareb, Emad
TI Hemorrhagic Fever with Renal Syndrome and Crimean-Congo Hemorrhagic
Fever as Causes of Acute Undifferentiated Febrile Illness in Bulgaria
SO VECTOR-BORNE AND ZOONOTIC DISEASES
LA English
DT Article
DE Hantaviruses; Crimean-Congo hemorrhagic fever virus; Acute febrile
illness
ID GENETIC DETECTION; DOBRAVA/BELGRADE VIRUS; HANTAVIRUS INFECTIONS;
HANTAAN-VIRUS; DNA VACCINES; PUUMALA; GREECE; IMMUNOGENICITY; ALBANIA;
DOBRAVA
AB Hemorrhagic fever with renal syndrome (HFRS) and Crimean-Congo hemorrhagic fever (CCHF) are the 2 widespread viral hemorrhagic fevers occurring in Europe. HFRS is distributed throughout Europe, and CCHF has been reported mainly on the Balkan Peninsula and Russia. Both hemorrhagic fevers are endemic in Bulgaria. We investigated to what extent acute undifferentiated febrile illness in Bulgaria could be due to hantaviruses or to CCHF virus. Using enzyme-linked immunosorbent assays (ELISAs), we tested serum samples from 527 patients with acute febrile illness for antibodies against hantaviruses and CCHF virus. Immunoglobulin M (IgM) antibodies against hantaviruses were detected in 15 (2.8%) of the patients. Of the 15 hantavirus-positive patients, 8 (1.5%) were positive for Dobrava virus (DOBV), 5 (0.9%) were positive for Puumala virus (PUUV), and the remaining 2 were positive for both hantaviruses. A plaque reduction neutralization test (PRNT) confirmed 4 of the 10 DOBV-positive samples. PRNT was negative for all PUUV-positive samples. Serologic evidence of recent CCHF virus infection was found in 13 (2.5%) of the patients. Interestingly, HFRS and CCHF were not only detected in well-known endemic areas of Bulgaria but also in nonendemic regions. Our results suggested that in endemic countries, CCHF and/or HFRS might appear as a nonspecific febrile illness in a certain proportion of patients. Physicians must be aware of possible viral hemorrhagic fever cases, even if hemorrhages or renal impairment are not manifested.
C1 [Christova, Iva; Taseva, Evgenia; Gladnishka, Teodora; Trifonova, Iva; Ivanova, Vladislava] Natl Ctr Infect & Parasit Dis, Natl Reference Tick Borne Infect Lab, Sofia 1504, Bulgaria.
[Younan, Rasha; Mohareb, Emad] US Naval Med Res Unit 3 NAMRU 3, Cairo, Egypt.
[Spik, Kristin; Schmaljohn, Connie] USA, Med Res Inst Infect Dis, Frederick, MD USA.
RP Christova, I (reprint author), Natl Ctr Infect & Parasit Dis, Natl Reference Tick Borne Infect Lab, Blvd Yanko Sakazov 26, Sofia 1504, Bulgaria.
EM iva_christova@yahoo.com
FU Global Emerging Infections Surveillance Response System (GIES) funds
work unit [847705.82000.25GB.E0018]
FX This work was supported by the Global Emerging Infections Surveillance
Response System (GIES) funds work unit # 847705.82000.25GB.E0018. This
study protocol was approved by the Institute Review Board (IRB DoD#
NAMRU-3.2008.003) in compliance with federal regulations governing the
protection of human subjects. We are thankful to Mr. Mohamed Abdel
Moemen for excellent technical assistance.
NR 32
TC 6
Z9 6
U1 0
U2 3
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1530-3667
J9 VECTOR-BORNE ZOONOT
JI Vector-Borne Zoonotic Dis.
PD MAR
PY 2013
VL 13
IS 3
BP 188
EP 192
DI 10.1089/vbz.2011.0938
PG 5
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 107AH
UT WOS:000316186500008
PM 23421884
ER
PT J
AU Hong, S
Jia, S
Xie, P
Xu, W
Leung, KP
Mustoe, TA
Galiano, RD
AF Hong, S.
Jia, S.
Xie, P.
Xu, W.
Leung, K. P.
Mustoe, T. A.
Galiano, R. D.
TI USE OF MESENCHYMAL STEM CELLS TO ENHANCE WOUND HEALING AND REDUCE
HYPERTROPHIC SCARS
SO WOUND REPAIR AND REGENERATION
LA English
DT Meeting Abstract
C1 [Hong, S.; Jia, S.; Xie, P.; Xu, W.; Mustoe, T. A.; Galiano, R. D.] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA.
[Leung, K. P.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR-APR
PY 2013
VL 21
IS 2
BP A26
EP A26
PG 1
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 103KI
UT WOS:000315914400054
ER
PT J
AU Cao, XY
Birdwell, JE
Chappell, MA
Li, Y
Pignatello, JJ
Mao, JD
AF Cao, Xiaoyan
Birdwell, Justin E.
Chappell, Mark A.
Li, Yuan
Pignatello, Joseph J.
Mao, Jingdong
TI Characterization of oil shale, isolated kerogen, and postpyrolysis
residues using advanced C-13 solid-state nuclear magnetic resonance
spectroscopy
SO AAPG BULLETIN
LA English
DT Article
ID NMR-SPECTROSCOPY; THERMAL MATURATION; HUMIC SUBSTANCES; MAS NMR;
PYROLYSIS; CARBON; DEGRADATION; MATTER
AB Characterization of oil shale kerogen and organic residues remaining in postpyrolysis spent shale is critical to the understanding of the oil generation process and approaches to dealing with issues related to spent shale. The chemical structure of organic matter in raw oil shale and spent shale samples was examined in this study using advanced solid-state C-13 nuclear magnetic resonance (NMR) spectroscopy. Oil shale was collected from Mahogany zone outcrops in the Piceance Basin. Five samples were analyzed: (1) raw oil shale, (2) isolated kerogen, (3) oil shale extracted with chloroform, (4) oil shale retorted in an open system at 500 degrees C to mimic surface retorting, and (5) oil shale retorted in a closed system at 360 degrees C to simulate in-situ retorting. The NMR methods applied included quantitative direct polarization with magic-angle spinning at 13 kHz, cross polarization with total sideband suppression, dipolar dephasing, CHn selection, C-13 chemical shift anisotropy filtering, and H-1-C-13 long-range recoupled dipolar dephasing. The NMR results showed that, relative to the raw oil shale, (1) bitumen extraction and kerogen isolation by demineralization removed some oxygen-containing and alkyl moieties; (2) unpyrolyzed samples had low aromatic condensation; (3) oil shale pyrolysis removed aliphatic moieties, leaving behind residues enriched in aromatic carbon; and (4) oil shale retorted in an open system at 500 degrees C contained larger aromatic clusters and more protonated aromatic moieties than oil shale retorted in a closed system at 360 degrees C, which contained more total aromatic carbon with a wide range of cluster sizes.
C1 [Cao, Xiaoyan; Li, Yuan; Mao, Jingdong] Old Dominion Univ, Dept Chem & Biochem, Norfolk, VA 23529 USA.
[Birdwell, Justin E.] US Geol Survey, Denver Fed Ctr, Denver, CO 80225 USA.
[Chappell, Mark A.] USA, Environm Lab, Corps Engineers, Vicksburg, MS USA.
[Pignatello, Joseph J.] Connecticut Agr Expt Stn, Dept Environm Sci, New Haven, CT 06504 USA.
RP Cao, XY (reprint author), Old Dominion Univ, Dept Chem & Biochem, Norfolk, VA 23529 USA.
EM xcao@odu.edu; jbirdwell@usgs.gov; mark.a.chappell@usace.army.mil;
yxxli001@odu.edu; joseph.pignatello@ct.gov; jmao@odu.edu
RI Cao, Xiaoyan/E-3492-2012;
OI Cao, Xiaoyan/0000-0001-7571-6482; Birdwell, Justin/0000-0001-8263-1452
FU National Science Foundation [CBET-0853950, CBET-0853682]
FX We thank the National Science Foundation (CBET-0853950 and CBET-0853682)
for financial support. We also thank the following colleagues for their
assistance with the various experimental aspects of this work: Mike
Lewan (ISS pyrolysis experiments, kerogen isolation, and sample
collection) and Ron Hill (sample collection). The results presented in
the manuscript were first publicized at the 28th Annual Meeting of The
Society for Organic Petrology held in Halifax, Nova Scotia, Canada, July
31 to August 4, 2011. Any use of trade, product, or firm names is for
descriptive purposes only and does not imply endorsement by the U.S.
Government.
NR 33
TC 9
Z9 9
U1 0
U2 50
PU AMER ASSOC PETROLEUM GEOLOGIST
PI TULSA
PA 1444 S BOULDER AVE, PO BOX 979, TULSA, OK 74119-3604 USA
SN 0149-1423
J9 AAPG BULL
JI AAPG Bull.
PD MAR
PY 2013
VL 97
IS 3
BP 421
EP 436
DI 10.1306/09101211189
PG 16
WC Geosciences, Multidisciplinary
SC Geology
GA 100ZS
UT WOS:000315745100004
ER
PT J
AU Munger, KL
Levin, LI
Massa, J
Horst, R
Orban, T
Ascherio, A
AF Munger, Kassandra L.
Levin, Lynn I.
Massa, Jennifer
Horst, Ronald
Orban, Tihamer
Ascherio, Alberto
TI Preclinical Serum 25-Hydroxyvitamin D Levels and Risk of Type 1 Diabetes
in a Cohort of US Military Personnel
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE nested case-control study; type 1 diabetes; vitamin D
ID REGULATORY T-CELLS; VITAMIN-D LEVELS; COD-LIVER OIL;
1,25-DIHYDROXYVITAMIN D-3; MULTIPLE-SCLEROSIS; AUTOIMMUNE-DISEASES;
PANCREATIC-ISLETS; NOD MICE; PREVENTION; MELLITUS
AB To determine whether serum levels of 25-hydroxyvitamin D (25(OH)D) in young adults are associated with risk of type 1 diabetes mellitus (T1D), we conducted a prospective, nested case-control study among US activeduty military personnel with serum in the US Department of Defense Serum Repository, identifying 310 T1D cases diagnosed between 1997 and 2009 with at least 2 serum samples collected before disease onset and 613 controls matched to cases on age, sex, race/ethnicity, branch of military service, and dates of serum collection. Conditional logistic regression was used to estimate rate ratios and 95% confidence intervals. Among non-Hispanic whites, those with average 25(OH)D levels of >= 100 nmol/L had a 44% lower risk of developing T1D than those with average 25(OH)D levels <75 nmol/L (rate ratio = 0.56, 95% confidence interval: 0.35, 0.90, P for trend = 0.03) over an average follow-up of 5.4 years. In quintile analyses, T1D risk was highest among individuals whose 25(OH)D levels were in the lowest 20% of those measured. There was no association between 25(OH)D levels and risk of T1D among non-Hispanic blacks or Hispanics. Low 25(OH)D levels may predispose healthy, young, non-Hispanic white adults to the development of T1D.
C1 [Munger, Kassandra L.; Massa, Jennifer; Ascherio, Alberto] Harvard Univ, Harvard Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
[Levin, Lynn I.] Walter Reed Army Inst Res, Dept Epidemiol, Div Prevent Med, Silver Spring, MD USA.
[Massa, Jennifer; Ascherio, Alberto] Harvard Univ, Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
[Horst, Ronald] Heartland Assays, Ames, IA USA.
[Orban, Tihamer] Orban Biotech LLC, Boston, MA USA.
[Ascherio, Alberto] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA.
[Ascherio, Alberto] Harvard Univ, Harvard Med Sch, Boston, MA 02115 USA.
RP Munger, KL (reprint author), Harvard Univ, Sch Publ Hlth, 665 Huntington Ave,Bldg 2,3rd Floor, Boston, MA 02115 USA.
EM kgorham@hsph.harvard.edu
FU National Institute of Neurological Disorders and Stroke [NS046635]
FX This study was funded by the National Institute of Neurological
Disorders and Stroke (grant NS046635).
NR 43
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U1 0
U2 10
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD MAR 1
PY 2013
VL 177
IS 5
BP 411
EP 419
DI 10.1093/aje/kws243
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 100LV
UT WOS:000315703600006
PM 23380046
ER
PT J
AU Ji, MK
Kim, HC
Sapireddy, VR
Yun, HS
Abou-Shanab, RAI
Choi, J
Lee, W
Timmes, TC
Inamuddin
Jeon, BH
AF Ji, Min-Kyu
Kim, Hyun-Chul
Sapireddy, Veer Raghavulu
Yun, Hyun-Shik
Abou-Shanab, Reda A. I.
Choi, Jaeyoung
Lee, Wontae
Timmes, Thomas C.
Inamuddin
Jeon, Byong-Hun
TI Simultaneous nutrient removal and lipid production from pretreated
piggery wastewater by Chlorella vulgaris YSW-04
SO APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
LA English
DT Article
DE Piggery effluent; Microalgae; Nitrogen species; Phosphorus; Lipids;
Fatty acids
ID STRUVITE PRECIPITATION; SCENEDESMUS-OBLIQUUS; AZOSPIRILLUM-BRASILENSE;
ANAEROBIC-DIGESTION; PHOSPHORUS REMOVAL; GROWTH; MICROALGAE; NITROGEN;
PURIFICATION; EXTRACTION
AB The feasibility of using a microalga Chlorella vulgaris YSW-04 was investigated for removal of nutrients from piggery wastewater effluent. The consequent lipid production by the microalga was also identified and quantitatively determined. The wastewater effluent was diluted to different concentrations ranging from 20 to 80 % of the original using either synthetic media or distilled water. The dilution effect on both lipid production and nutrient removal was evaluated, and growth rate of C. vulgaris was also monitored. Dilution of the wastewater effluent improved microalgal growth, lipid productivity, and nutrient removal. The growth rate of C. vulgaris was increased with decreased concentration of piggery wastewater in the culture media regardless of the diluent type. Lipid production was relatively higher when using synthetic media than using distilled water for dilution of wastewater. The composition of fatty acids accumulated in microalgal biomass was dependent upon both dilution ratio and diluent type. The microalga grown on a 20 % concentration of wastewater effluent diluted with distilled water was more promising for generating high-efficient biodiesel compared to the other culture conditions. The highest removal of inorganic nutrients was also achieved at the same dilution condition. Our results revealed the optimal pretreatment condition for the biodegradation of piggery wastewater with microalgae for subsequent production of high-efficient biodiesel.
C1 [Ji, Min-Kyu; Sapireddy, Veer Raghavulu; Yun, Hyun-Shik; Jeon, Byong-Hun] Yonsei Univ, Dept Environm Engn, Wonju 220710, South Korea.
[Kim, Hyun-Chul] Penn State Univ, Dept Civil & Environm Engn, University Pk, PA 16802 USA.
[Abou-Shanab, Reda A. I.] City Sci Res & Technol Applicat, Dept Environm Biotechnol, Alexandria 21934, Egypt.
[Choi, Jaeyoung] Korea Inst Sci & Technol KIST, Gangneung Inst, Kangnung 210340, South Korea.
[Lee, Wontae] Kumoh Natl Inst Technol, Sch Civil & Environm Engn, Gumi 730701, South Korea.
[Timmes, Thomas C.] US Mil Acad, Dept Geog & Environm Engn, West Point, NY 10996 USA.
[Inamuddin] Aligarh Muslim Univ, Fac Engn & Technol, Dept Appl Chem, Aligarh 202002, Uttar Pradesh, India.
RP Jeon, BH (reprint author), Yonsei Univ, Dept Environm Engn, Wonju 220710, South Korea.
EM bhjeon@yonsei.ac.kr
RI City for Scientific , and Research/E-6802-2017;
OI Jeon, Byong-Hun/0000-0002-5478-765X; Abou-Shanab,
Reda/0000-0002-3338-8094
FU Korea Institute of Energy Research; Senior Researchers program (the
National Research Foundation of Korea) [2010-0026904]; Eco-Innovation
project (Global-Top project) of the Korea Ministry of Environment; Brain
Korea-21 (BK-21) program of the Korea Ministry of Education, Science &
Technology (MEST)
FX This work was supported by the Korea Institute of Energy Research, the
Senior Researchers program (the National Research Foundation of Korea,
2010-0026904), the Eco-Innovation project (Global-Top project) of the
Korea Ministry of Environment, and the Brain Korea-21 (BK-21) program of
the Korea Ministry of Education, Science & Technology (MEST).
NR 35
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U1 2
U2 80
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0175-7598
J9 APPL MICROBIOL BIOT
JI Appl. Microbiol. Biotechnol.
PD MAR
PY 2013
VL 97
IS 6
BP 2701
EP 2710
DI 10.1007/s00253-012-4097-x
PG 10
WC Biotechnology & Applied Microbiology
SC Biotechnology & Applied Microbiology
GA 099VF
UT WOS:000315650100039
PM 22569638
ER
PT J
AU Grandusky, JR
Chen, JF
Gibb, SR
Mendrick, MC
Moe, CG
Rodak, L
Garrett, GA
Wraback, M
Schowalter, LJ
AF Grandusky, James R.
Chen, Jianfeng
Gibb, Shawn R.
Mendrick, Mark C.
Moe, Craig G.
Rodak, Lee
Garrett, Gregory A.
Wraback, Michael
Schowalter, Leo J.
TI 270 nm Pseudomorphic Ultraviolet Light-Emitting Diodes with Over 60 mW
Continuous Wave Output Power
SO APPLIED PHYSICS EXPRESS
LA English
DT Article
ID ALN
AB In this letter, the achievement of over 60 mW output power from pseudomorphic ultraviolet light-emitting diodes in continuous wave operation is reported. Die thinning and encapsulation improved the photon extraction efficiency to over 15%. Improved thermal management and a high characteristic temperature resulted in a low thermal rolloff up to 300 mA injection current with an output power of 67 mW, an external quantum efficiency (EQE) of 4.9%, and a wall plug efficiency (WPE) of 2.5% for a single-chip device emitting at 271 nm in continuous wave operation. (C) 2013 The Japan Society of Applied Physics
C1 [Grandusky, James R.; Chen, Jianfeng; Gibb, Shawn R.; Mendrick, Mark C.; Moe, Craig G.; Schowalter, Leo J.] Crystal IS Inc, Green Isl, NY 12183 USA.
[Rodak, Lee; Garrett, Gregory A.; Wraback, Michael] USA, Res Lab, RDRL SEE M, Adelphi, MD 20783 USA.
RP Grandusky, JR (reprint author), Crystal IS Inc, 70 Cohoes Ave, Green Isl, NY 12183 USA.
EM grandusky@crystal-is.com
FU Defense Advanced Research Projects Agency (DARPA); Army Research
Laboratory (ARL) [W911NF-09-2-0068]
FX This material is based on work partially supported by the Defense
Advanced Research Projects Agency (DARPA) under the Compact
Mid-Ultraviolet Technology program and a Cooperative Agreement (Number
W911NF-09-2-0068) with the Army Research Laboratory (ARL).
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U1 7
U2 43
PU JAPAN SOC APPLIED PHYSICS
PI TOKYO
PA KUDAN-KITA BUILDING 5TH FLOOR, 1-12-3 KUDAN-KITA, CHIYODA-KU, TOKYO,
102-0073, JAPAN
SN 1882-0778
J9 APPL PHYS EXPRESS
JI Appl. Phys. Express
PD MAR
PY 2013
VL 6
IS 3
AR 032101
DI 10.7567/APEX.6.032101
PG 3
WC Physics, Applied
SC Physics
GA 103SB
UT WOS:000315938100003
ER
PT J
AU Dzialowski, AR
Bonneau, JL
Gemeinhardt, TR
AF Dzialowski, Andrew R.
Bonneau, Joseph L.
Gemeinhardt, Todd R.
TI Comparisons of zooplankton and phytoplankton in created shallow water
habitats of the lower Missouri River: implications for native fish
SO AQUATIC ECOLOGY
LA English
DT Article
DE Backwater; Chute; River restoration; Great rivers; Shallow water habitat
ID FLOW REGULATION; FLOODPLAIN RIVER; LOWLAND RIVER; MAIN CHANNEL;
DYNAMICS; COMMUNITY; CONNECTIVITY; IMPOUNDMENTS; ECOSYSTEMS; ABUNDANCE
AB Shallow water habitat (SWH) is important for riverine fish and their invertebrate prey, yet the availability of SWH has declined in many systems due to human impacts. We evaluated the potential ecological benefits of restoring SWH by comparing zooplankton and phytoplankton from created backwaters (a floodplain feature connected to the river on the downstream end but disconnected at the upstream end) and chutes (a side channel of the river that diverts flow from the main channel through the chute and back into the main channel) on the lower Missouri River. We tested the hypothesis that backwaters support higher abundances of zooplankton and phytoplankton than chutes using data that were collected during the summer of 2010. As predicted, backwaters had more diverse cladoceran communities and greater abundances of rotifers, copepod nauplii, adult copepods, and cladocerans than chutes. Total algal biovolume was the same in chutes and backwaters; however, phytoplankton taxa richness was higher in backwaters, and there was a greater biovolume of green algae (Chlorophyta), Crypotophyta, cyanobacteria, and Euglenophyta in backwaters than in chutes. Differences in zooplankton and phytoplankton between backwaters and chutes appeared to be related to slower current velocities, longer retention times, and lower levels of turbidity and total suspended solids in backwaters. While chutes have the potential to provide greater habitat diversity than the mainstem, there were no differences in water quality or phytoplankton abundance, community structure, or diversity between these two habitats. Combined, our results suggest that created backwaters initially provide a greater potential food resource for native fishes. However, additional research is needed to determine whether chutes can also develop beneficial shallow water features over a longer period of time.
C1 [Dzialowski, Andrew R.] Oklahoma State Univ, Dept Zool, Stillwater, OK 74074 USA.
[Bonneau, Joseph L.] US Army Corps Engineers, Threatened & Endangered Species Sect, Yankton, SD USA.
[Gemeinhardt, Todd R.] US Army Corps Engineers, Environm Resources Sect, Kansas City, MO 64106 USA.
RP Dzialowski, AR (reprint author), Oklahoma State Univ, Dept Zool, Stillwater, OK 74074 USA.
EM andy.dzialowski@okstate.edu; Joseph.L.Bonneau@usace.army.mil;
Todd.R.Gemeinhardt@usace.army.mil
NR 55
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U1 5
U2 47
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1386-2588
EI 1573-5125
J9 AQUAT ECOL
JI Aquat. Ecol.
PD MAR
PY 2013
VL 47
IS 1
BP 13
EP 24
DI 10.1007/s10452-012-9421-0
PG 12
WC Ecology; Limnology; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA 104QM
UT WOS:000316009500002
ER
PT J
AU Keshtpoor, M
Puleo, JA
Gebert, J
Plant, NG
AF Keshtpoor, Mohammad
Puleo, Jack A.
Gebert, Jeffrey
Plant, Nathaniel G.
TI Beach response to a fixed sand bypassing system
SO COASTAL ENGINEERING
LA English
DT Article
ID ORTHOGONAL FUNCTION-ANALYSIS; SEDIMENT TRANSPORT; SHORELINE VARIABILITY;
DOWNDRIFT EROSION; INLET; EVOLUTION
AB Indian River Inlet is located at roughly the mid-point of the Atlantic coast of Delaware and connects the ocean to two Delaware inland bays. jetties constructed in 1940 have maintained the inlet for navigation purposes but have also acted as a barrier to net northerly alongshore sediment transport causing downdrift erosion. A mobile, land-based bypassing system was initiated in 1990 in an effort to counteract this erosion. Beach profile data from 1985 (pre-bypassing) until 2008 are used to investigate the effect of the sand bypassing system on beaches adjacent to the inlet. The downdrift beach experienced horizontal shoreline erosion between 10 and 60 m during the pre-bypassing period but accreted 10-20 m during the bypassing period. The mean shoreline location on the updrift beach during bypassing is 10-20 m landward (erosion) of its position during the pre-bypassing period. Empirical orthogonal function (EOF) amplitudes from analyses performed on mean-removed elevation surfaces during the periods of highest bypassed volume (average of 83% of design rate) showed that the influence of the bypassing system on the downdrift beach extends to about 1500 m of the inlet. An EOF analysis showed that different morphologic responses were evident following the initiation of bypass operations. Temporal variations of shoreline and beach morphology were correlated to the temporal variations in bypassing rates on the downdrift beach only. The downdrift beach response was greatest near the inlet for larger bypassing volumes. Correlation in these instances occurred with a roughly 1-year time lag suggesting that the beach quickly redistributes the bypassed sand. EOF amplitude and shoreline response are weakly correlated to bypassed volumes when the system bypassed smaller volumes (average of 56% of design rate) of sand suggesting that there is a minimum bypassing rate, regardless of yearly variability, below which the effect on the downdrift beach is obscured. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Keshtpoor, Mohammad; Puleo, Jack A.] Univ Delaware, Ctr Appl Coastal Res, Dept Civil & Environm Engn, Newark, DE 19716 USA.
[Gebert, Jeffrey] USA, Corps Engineers, Coastal Planning Sect, Philadelphia, PA 19107 USA.
[Plant, Nathaniel G.] US Geol Survey, St Petersburg Coastal & Marine Sci Ctr, St Petersburg, FL 33701 USA.
RP Keshtpoor, M (reprint author), Univ Delaware, Ctr Appl Coastal Res, Dept Civil & Environm Engn, Newark, DE 19716 USA.
EM mkesht@udel.edu; jpuleo@udel.edu; Jeffrey.A.Gebert@usace.army.mil;
nplant@usgs.gov
OI Plant, Nathaniel/0000-0002-5703-5672
FU Delaware Department of Transportation, Delaware Department of Natural
Resources and Environmental Control; University of Delaware; National
Oceanic and Atmospheric Administration US Department of Commerce
[R/ETE-14]
FX This work was funded by the Delaware Department of Transportation,
Delaware Department of Natural Resources and Environmental Control and
the University of Delaware. Additional funds were provided by the
National Oceanic and Atmospheric Administration US Department of
Commerce under award number R/ETE-14. The statements, findings,
conclusions, and recommendations are those of the author(s) and do not
necessarily reflect the views of the National Oceanic and Atmospheric
Administration or the Department of Commerce. We thank two reviewers
that provided detailed comments to improve the clarity of this paper.
NR 53
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U1 2
U2 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-3839
J9 COAST ENG
JI Coast. Eng.
PD MAR
PY 2013
VL 73
BP 28
EP 42
DI 10.1016/j.coastaleng.2012.09.006
PG 15
WC Engineering, Civil; Engineering, Ocean
SC Engineering
GA 099IO
UT WOS:000315614900004
ER
PT J
AU Bender, C
Smith, JM
Kennedy, A
Jensen, R
AF Bender, Christopher
Smith, Jane McKee
Kennedy, Andrew
Jensen, Robert
TI STWAVE simulation of Hurricane Ike: Model results and comparison to data
SO COASTAL ENGINEERING
LA English
DT Article
DE Waves; Hurricanes; Wave measurement; Bottom friction
AB Hurricane Ike (2008), with its associated storm surge, caused extensive damage across parts of the northwestern Gulf Coast when it made landfall in the late hours of September 12, 2008 along the upper Texas coast at the upper end of Category 2 intensity. An extensive instrumentation effort allowed the collection of both nearshore and inland wave and water level data as Hurricane Ike passed the Louisiana coast and made landfall in Texas. This article presents the results of a validation effort for the STWAVE model and the bottom friction coefficients applied in the model with comparisons to the Hurricane Ike measured wave data. Examination of STWAVE model results as contour plots and time series of wave height and period; wave spectra at selected time steps and scatter plots of simulated versus modeled wave results allow evaluation of the model performance. STWAVE model results indicate good agreement with the measured nearshore wave data for an open water Manning 'n' bottom friction coefficient equal to 0.03 s/m(0.33). STWAVE model results indicate good agreement with the measured inshore wave data with Manning bottom friction coefficients equal to values derived from land classification data and applied in the ADCIRC model. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Bender, Christopher] Taylor Engn Inc, Jacksonville, FL 32259 USA.
[Smith, Jane McKee; Jensen, Robert] Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA.
[Kennedy, Andrew] Univ Notre Dame, Dept Civil Engn & Geol Sci, South Bend, IN 46556 USA.
RP Bender, C (reprint author), Taylor Engn Inc, 10510 Deerwood Pk Blvd,Bldg 300,Suite 300, Jacksonville, FL 32259 USA.
EM cbender@taylorengineering.com; Jane.M.Smith@usace.army.mil;
andrew.kennedy@nd.edu; Robert.E.Jensen@usace.army.mil
RI Kennedy, Andrew/E-4746-2011
OI Kennedy, Andrew/0000-0002-7254-1346
FU Flood and Coastal Systems RD Program
FX Permission to publish this work was granted by the Chief of Engineers,
U.S. Army Corps of Engineers. Partial support was provided by the Flood
and Coastal Systems R&D Program. The Notre Dame-University of Florida
team members Uriah Gravois and Brian Zachry are acknowledged for
collection and analysis of the ND-UF Hurricane Ike data.
NR 20
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Z9 4
U1 0
U2 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-3839
J9 COAST ENG
JI Coast. Eng.
PD MAR
PY 2013
VL 73
BP 58
EP 70
DI 10.1016/j.coastaleng.2012.10.003
PG 13
WC Engineering, Civil; Engineering, Ocean
SC Engineering
GA 099IO
UT WOS:000315614900006
ER
PT J
AU Chesnut, G
Taylor, S
Belin, E
AF Chesnut, Gregory
Taylor, Sarah
Belin, Eric
TI What Is Your Diagnosis?
SO CUTIS
LA English
DT Editorial Material
ID MEES LINES; CHEMOTHERAPY
C1 Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Taylor, Sarah] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA.
[Belin, Eric] Natl Naval Ctr, Bethesda, MD USA.
RP Taylor, S (reprint author), 428 Southwest Dr, Silver Spring, MD 20901 USA.
EM sktaylor1@yahoo.com
NR 5
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U1 0
U2 0
PU QUADRANT HEALTHCOM INC
PI PARSIPPANY
PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA
SN 0011-4162
J9 CUTIS
JI Cutis
PD MAR
PY 2013
VL 91
IS 3
BP 147
EP +
PG 3
WC Dermatology
SC Dermatology
GA 105AQ
UT WOS:000316038400011
PM 23617087
ER
PT J
AU Knapik, JJ
Harman, EA
AF Knapik, Joseph J.
Harman, Everett A.
TI Untitled Reply
SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
LA English
DT Letter
C1 [Knapik, Joseph J.] USA, Inst Publ Hlth, Injury Prevent Program, Aberdeen Proving Ground, MD USA.
RP Knapik, JJ (reprint author), USA, Inst Publ Hlth, Injury Prevent Program, Aberdeen Proving Ground, MD USA.
NR 0
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U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1064-8011
J9 J STRENGTH COND RES
JI J. Strength Cond. Res.
PD MAR
PY 2013
VL 27
IS 3
BP E1
EP E2
DI 10.1097/01.JSC.0000428152.41604.df
PG 3
WC Sport Sciences
SC Sport Sciences
GA 099CI
UT WOS:000315596500002
PM 23565543
ER
PT J
AU Taflanidis, AA
Jia, GF
Kennedy, AB
Smith, JM
AF Taflanidis, Alexandros A.
Jia, Gaofeng
Kennedy, Andrew B.
Smith, Jane M.
TI Implementation/optimization of moving least squares response surfaces
for approximation of hurricane/storm surge and wave responses
SO NATURAL HAZARDS
LA English
DT Article
DE Hurricane wave and surge; Coastal hazard; Storm surge; Tropical
cyclones; Response surface approximations; Surrogate modelling
optimization; Risk assessment
ID HAZARD; OPTIMIZATION
AB One of the important recent advances in the field of hurricane/storm modelling has been the development of high-fidelity numerical simulation models for reliable and accurate prediction of wave and surge responses. The computational cost associated with these models has simultaneously created an incentive for researchers to investigate surrogate modelling (i.e. metamodeling) and interpolation/regression methodologies to efficiently approximate hurricane/storm responses exploiting existing databases of high-fidelity simulations. Moving least squares (MLS) response surfaces were recently proposed as such an approximation methodology, providing the ability to efficiently describe different responses of interest (such as surge and wave heights) in a large coastal region that may involve thousands of points for which the hurricane impact needs to be estimated. This paper discusses further implementation details and focuses on optimization characteristics of this surrogate modelling approach. The approximation of different response characteristics is considered, and special attention is given to predicting the storm surge for inland locations, for which the possibility of the location remaining dry needs to be additionally addressed. The optimal selection of the basis functions for the response surface and of the parameters of the MLS character of the approximation is discussed in detail, and the impact of the number of high-fidelity simulations informing the surrogate model is also investigated. Different normalizations of the response as well as choices for the objective function for the optimization problem are considered, and their impact on the accuracy of the resultant (under these choices) surrogate model is examined. Details for implementation of the methodology for efficient coastal risk assessment are reviewed, and the influence in the analysis of the model prediction error introduced through the surrogate modelling is discussed. A case study is provided, utilizing a recently developed database of high-fidelity simulations for the Hawaiian Islands.
C1 [Taflanidis, Alexandros A.; Jia, Gaofeng; Kennedy, Andrew B.] Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, Notre Dame, IN 46556 USA.
[Smith, Jane M.] USA, Corps Engineers, Ctr Res & Dev, Vicksburg, MS 39180 USA.
RP Taflanidis, AA (reprint author), Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, 156 Fitzpatrick Hall, Notre Dame, IN 46556 USA.
EM a.taflanidis@nd.edu
RI Kennedy, Andrew/E-4746-2011; Jia, Gaofeng/M-8369-2014;
OI Kennedy, Andrew/0000-0002-7254-1346; Jia, Gaofeng/0000-0001-9419-8481;
Taflanidis, Alexandros/0000-0002-9784-7480
FU US Army Corps of Engineering [W912HZ-09-C-0086]
FX This research effort is partially supported by US Army Corps of
Engineering grant W912HZ-09-C-0086 under the Surge and Wave Island
Modeling Studies, Coastal Field Data Collection Program. This support is
greatly appreciated. Permission to publish this work was granted by the
Chief of Engineers, US Army Corps of Engineers. Also the contribution of
Professor Joannes Westerink and graduate student Mark Hope, both at the
University of Notre Dame, in developing and performing the high-fidelity
simulations for the illustrative example is greatly appreciated.
NR 32
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U1 1
U2 15
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0921-030X
EI 1573-0840
J9 NAT HAZARDS
JI Nat. Hazards
PD MAR
PY 2013
VL 66
IS 2
BP 955
EP 983
DI 10.1007/s11069-012-0520-y
PG 29
WC Geosciences, Multidisciplinary; Meteorology & Atmospheric Sciences;
Water Resources
SC Geology; Meteorology & Atmospheric Sciences; Water Resources
GA 093BG
UT WOS:000315166100043
ER
PT J
AU Agazio, J
Coe, TR
Goodman, P
McNeil, P
Nayback, A
Padden, D
Steffan, N
Throop, M
AF Agazio, Janice
Coe, Thomas Ray
Goodman, Petra
McNeil, Peggy
Nayback, Ann
Padden, Diane
Steffan, Nancy
Throop, Meryia
TI Management of Ethical Issues by Military Nurses in Wartime
SO NURSING RESEARCH
LA English
DT Meeting Abstract
C1 [Agazio, Janice; Steffan, Nancy] Catholic Univ Amer, Washington, DC 20064 USA.
[Goodman, Petra; McNeil, Peggy; Throop, Meryia] Walter Reed Natl Mil Med Ctr, Silver Spring, MD USA.
[Nayback, Ann] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
[Padden, Diane] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0029-6562
J9 NURS RES
JI Nurs. Res.
PD MAR-APR
PY 2013
VL 62
IS 2
BP E15
EP E15
PG 1
WC Nursing
SC Nursing
GA 103WX
UT WOS:000315951300042
ER
PT J
AU Altieri, M
Jindal, TR
Patel, M
Oliver, DK
Falta, EM
Elster, EA
Doyle, A
Guy, SR
Womble, AL
Jindal, RM
AF Altieri, Maria
Jindal, Tarun R.
Patel, Mayur
Oliver, David K.
Falta, Edward M.
Elster, Eric A.
Doyle, Alden
Guy, Stephen R.
Womble, Arthur L.
Jindal, Rahul M.
TI REPORT OF THE FIRST PERITONEAL DIALYSIS PROGRAM IN GUYANA, SOUTH AMERICA
SO PERITONEAL DIALYSIS INTERNATIONAL
LA English
DT Article
DE Developing countries; Guyana; South America; outcomes; infection; kidney
transplantation; logistics of peritoneal dialysis; supply of dialysis
fluids
ID CHRONIC KIDNEY-DISEASE; STAGE RENAL-DISEASE; HEMODIALYSIS; SURVIVAL;
COST; MORTALITY; MODALITY; WORLD; CARE
AB Introduction: In 2008, we initiated the first Guyanese comprehensive kidney replacement program, comprising hemodialysis (HD), peritoneal dialysis (PD), vascular access procedures, and living-donor kidney transplantation. The government of Guyana, US-based philanthropists, US-based physicians, and Guyanese caregivers teamed up to form a public-private partnership. This pilot program was free of cost to the patients.
Methods: From July 2010 to the time of writing, we placed 17 patients with end-stage kidney disease on PD, which was used as a bridge to living-donor kidney transplantation. During the same period, we placed 12 primary arteriovenous fistulae.
Results: The 17 patients who received a PD catheter had a mean age of 43.6 years and a mean follow-up of 5.3 months. In that group, 2 deaths occurred (from multi-organ failure) within 2 weeks of catheter placement, and 2 patients were switched to HD because of inadequate clearance. Technical issues were noted in 2 patients, and 3 patients developed peritonitis (treated with intravenous antibiotics). An exit-site abscess in 1 patient was drained under local anesthesia. The peritonitis rate was 0.36 episodes per patient-year. Of the 17 patients who received PD, 4 underwent living-donor kidney transplantation.
Conclusions: In Guyana, PD is a safe and cost-effective option; it may be equally suitable for similar developing countries. In Guyana, PD was used as a bridge to living-donor kidney transplantation. We have been able to sustain this program since 2008 by making incremental gains and nurturing the ongoing public-private partnership. Perit Dial Int 2013; 33(2): 116-123 www.PDIConnect.com doi:10.3747/pdi.2012.00001
C1 [Altieri, Maria] Stony Brook Univ Hosp, Long Isl City, NY USA.
[Jindal, Tarun R.] Indiana Univ Sch Med, Indianapolis, IL USA.
[Patel, Mayur] Rutgers State Univ, Piscataway, NJ 08855 USA.
[Oliver, David K.; Falta, Edward M.; Elster, Eric A.; Jindal, Rahul M.] Uniformed Serv Univ Hlth Sci, Bethesda, MD USA.
[Doyle, Alden; Guy, Stephen R.] Drexel Univ, Sch Med, Philadelphia, PA 19104 USA.
[Falta, Edward M.; Elster, Eric A.; Jindal, Rahul M.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA.
[Womble, Arthur L.] Southeastern Pain Management, Gadsden, AL USA.
[Womble, Arthur L.] US Army Reserve, Med Brigade 5, Birmingham, AL USA.
[Jindal, Rahul M.] George Washington Univ, Washington, DC USA.
RP Jindal, RM (reprint author), Walter Reed NMMC, Dept Transplantat, Bethesda, MD USA.
EM jindalr@msn.com
FU Zara Realty, Queens, New York
FX The authors thank Mr. George Subraj, philanthropist and president of
Zara Realty (http://www.zararealty.com), Queens, New York, who funded
the program; the Government of Guyana for the use of hospital space and
medications; the staff of Balwant Singh Hospital, Georgetown, Guyana,
where transplantation and related surgeries are performed; the
department of Pathology at Drexel University, Philadelphia, and the
Immunology Laboratory at Walter Reed National Military Medical Center.
NR 28
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U1 0
U2 3
PU MULTIMED INC
PI TORONTO
PA 66 MARTIN ST, TORONTO, ON L9T 2R2, CANADA
SN 0896-8608
J9 PERITON DIALYSIS INT
JI Perit. Dial. Int.
PD MAR-APR
PY 2013
VL 33
IS 2
BP 116
EP 123
DI 10.3747/pdi.2012.00001
PG 8
WC Urology & Nephrology
SC Urology & Nephrology
GA 104LR
UT WOS:000315995000003
PM 23478372
ER
PT J
AU Cheuvront, SN
Kenefick, RW
Charkoudian, N
Sawka, MN
AF Cheuvront, Samuel N.
Kenefick, Robert W.
Charkoudian, Nisha
Sawka, Michael N.
TI Physiologic basis for understanding quantitative dehydration assessment
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID PROGRESSIVE ACUTE DEHYDRATION; CEREBRAL-BLOOD-FLOW; HYDRATION STATUS;
PLASMA VASOPRESSIN; HEAT-STRESS; CLINICAL APPLICATION; WATER;
OSMOLALITY; EXERCISE; VOLUME
AB Dehydration (body water deficit) is a physiologic state that can have profound implications for human health and performance. Unfortunately, dehydration can be difficult to assess, and there is no single, universal gold standard for decision making. In this article, we review the physiologic basis for understanding quantitative dehydration assessment. We highlight how phenomenologic interpretations of dehydration depend critically on the type (dehydration compared with volume depletion) and magnitude (moderate compared with severe) of dehydration, which in turn influence the osmotic (plasma osmolality) and blood volume dependent compensatory thresholds for antidiuretic and thirst responses. In particular, we review new findings regarding the biological variation in osmotic responses to dehydration and discuss how this variation can help provide a quantitative and clinically relevant link between the physiology and phenomenology of dehydration. Practical measures with empirical thresholds are provided as a starting point for improving the practice of dehydration assessment. Am J Clin Nutr 2013;97:455-62.
C1 [Cheuvront, Samuel N.; Kenefick, Robert W.; Charkoudian, Nisha; Sawka, Michael N.] USA, Environm Med Res Inst, Natick, MA 01760 USA.
RP Cheuvront, SN (reprint author), USA, Thermal & Mt Med Div, Environm Med Res Inst, Kansas St,Bldg 42, Natick, MA 01760 USA.
EM samuel.n.cheuvront@us.army.mil
FU United States Army Medical Research and Materiel Command
FX Supported by the United States Army Medical Research and Materiel
Command.
NR 97
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U1 1
U2 42
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0002-9165
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD MAR
PY 2013
VL 97
IS 3
BP 455
EP 462
DI 10.3945/ajcn.112.044172
PG 8
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA 096UV
UT WOS:000315431000003
PM 23343973
ER
PT J
AU Li, BC
Hogue, J
Eilers, M
Mehrotra, P
Hyland, J
Holm, T
Prosen, T
Slavotinek, AM
AF Li, Ben C.
Hogue, Jacob
Eilers, Meg
Mehrotra, Pavni
Hyland, James
Holm, Tara
Prosen, Tracy
Slavotinek, Anne M.
TI Clinical report: Two patients with atelosteogenesis type I caused by
missense mutations affecting the same FLNB residue
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
DE atelosteogenesis type I; FLNB
ID SKELETAL DYSPLASIA; PRENATAL-DIAGNOSIS; FEATURES
AB We present two patients with Atelosteogenesis Type I (AO type I) caused by two novel Filamin B (FLNB) mutations affecting the same FLNB residue: c.542G>A, predicting p.Gly181Asp and c.542G>C, predicting p.Gly181Arg. Both children had typical manifestations of AO type I, with severe rhizomelic shortening of the extremities, limited elbow and knee extension with mild webbing, pectus excavatum, broad thumbs with brachydactyly that was most marked for digits 35, dislocated hips and bilateral talipes equinovarus. Facial features included proptosis, hypertelorism, downslanting palpebral fissures, cleft palate, and retromicrognathia. The clinical course of one child was influenced by airway instability and bronchopulmonary dysplasia that complicated intubation and prevented separation from ventilator support. Respiratory insufficiency with tracheal hypoplasia, laryngeal stenosis, and pulmonary hypoplasia have all been described in patients with AO type I and we conclude that compromised pulmonary function is a major contributor to morbidity and mortality in this condition. (c) 2013 Wiley Periodicals, Inc.
C1 [Li, Ben C.; Mehrotra, Pavni; Slavotinek, Anne M.] Univ Calif San Francisco, Div Genet, Dept Pediat, San Francisco, CA 94143 USA.
[Hogue, Jacob] Brooke Army Med Ctr, Div Genet, Dept Pediat, Ft Sam Houston, TX 78234 USA.
[Eilers, Meg; Holm, Tara; Prosen, Tracy] Univ Minnesota, Dept Obstet Gynecol & Womens Hlth, Div Maternal Fetal Med, Dept Diagnost Radiol, Minneapolis, MN USA.
[Hyland, James] Connect Tissue Gene Tests, Allentown, PA USA.
RP Slavotinek, AM (reprint author), Univ Calif San Francisco, Div Genet, Dept Pediat, 533 Parnassus St,Room U585P, San Francisco, CA 94143 USA.
EM slavotia@peds.ucsf.edu
NR 13
TC 2
Z9 2
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4825
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD MAR
PY 2013
VL 161A
IS 3
BP 619
EP 625
DI 10.1002/ajmg.a.35792
PG 7
WC Genetics & Heredity
SC Genetics & Heredity
GA 095NQ
UT WOS:000315341700031
PM 23401428
ER
PT J
AU Cameron, KL
Thompson, BS
Peck, KY
Owens, BD
Marshall, SW
Svoboda, SJ
AF Cameron, Kenneth L.
Thompson, Brandon S.
Peck, Karen Y.
Owens, Brett D.
Marshall, Stephen W.
Svoboda, Steven J.
TI Normative Values for the KOOS and WOMAC in a Young Athletic Population
History of Knee Ligament Injury Is Associated With Lower Scores
SO AMERICAN JOURNAL OF SPORTS MEDICINE
LA English
DT Article
DE KOOS; WOMAC; norms; reference values; sex; injury history
ID OSTEOARTHRITIS INDEX WOMAC; ANTERIOR CRUCIATE LIGAMENT;
WESTERN-ONTARIO-UNIVERSITY; CROSS-CULTURAL ADAPTATION; OF-LIFE
INSTRUMENTS; RATING-SCALES; VALIDATION; VERSION; PAIN
AB Background: The use of patient-reported outcome measures to assess clinical outcomes after injury and surgery has become common in treating young athletes with orthopaedic injuries; however, normative data for these measures are limited and often include a wide range of ages and activity levels.
Purpose: To provide normative data for the Knee Injury and Osteoarthritis Outcome Score (KOOS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) in a young and athletic population, and to compare scores between participants with a history of knee ligament injury and those with no history.
Study Design: Cross-sectional study; Level of evidence, 3.
Methods: We administered the KOOS and WOMAC to 1177 college freshmen entering the United States Military Academy in June 2011. All participants were healthy and had been medically screened to meet the physical induction standards for military service. We calculated means, standard deviations, percentiles, ranges, and interquartile ranges for the KOOS and WOMAC by sex and injury history. We also compared median scale scores for those with a history of knee ligament injury with those with no history using the Kruskal-Wallis test.
Results: Among the 1177 participants, 971 were male (age, 18.8 +/- 0.9 years), and the remaining 206 were female (age, 18.7 +/- 0.8 years). Normative median values and interquartile ranges (IQRs) for the KOOS scale scores among men with no history of knee ligament injury were the following: Symptoms (96.4; IQR, 10.7), Pain (100; IQR, 2.8), Functional Activities of Daily Living (ADL) (100; IQR, 0.0), Sports and Recreation Function (100; IQR, 5.0), and Knee-Related Quality of Life (QOL) (100; IQR, 12.5). For women with no history of knee ligament injury, the KOOS scale scores were the following: Symptoms (92.9; IQR, 14.3), Pain (100; IQR, 5.6), Functional ADL (100; IQR, 2.9), Sports and Recreation Function (100; IQR, 10.0), and Knee-Related QOL (93.8; IQR, 18.8). Among the men, 139 (14%) reported a history of knee ligament injury, while 33 (16%) women also reported a history of injury. All KOOS scale scores and the WOMAC Stiffness and Function scale scores were significantly lower (P < .05) for men who reported a history of knee ligament injury. Similarly, Symptoms, Pain, and Knee-Related QOL on the KOOS and Pain on the WOMAC were significantly lower among women with a history of knee ligament injury.
Conclusion: Normative values for all KOOS scales suggest a high level of functioning among participants with no history of knee ligament injury. Despite meeting the medical standards for military service, participants with a history of knee ligament injury had significantly lower KOOS and WOMAC scores upon entry to military service.
C1 [Cameron, Kenneth L.; Thompson, Brandon S.; Peck, Karen Y.; Owens, Brett D.; Marshall, Stephen W.; Svoboda, Steven J.] US Mil Acad, Keller Army Hosp, West Point, NY 10996 USA.
RP Cameron, KL (reprint author), Keller Army Community Hosp, 900 Washington Rd, West Point, NY 10996 USA.
EM kenneth.cameron@amedd.army.mil
OI Marshall, Stephen/0000-0002-2664-9233; Cameron,
Kenneth/0000-0002-6276-4482
NR 25
TC 11
Z9 11
U1 0
U2 8
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0363-5465
J9 AM J SPORT MED
JI Am. J. Sports Med.
PD MAR
PY 2013
VL 41
IS 3
BP 582
EP 589
DI 10.1177/0363546512472330
PG 8
WC Orthopedics; Sport Sciences
SC Orthopedics; Sport Sciences
GA 098QG
UT WOS:000315563200014
PM 23328737
ER
PT J
AU Owens, BD
Burns, TC
Campbell, SE
Svoboda, SJ
Cameron, KL
AF Owens, Brett D.
Burns, Travis C.
Campbell, Scot E.
Svoboda, Steven J.
Cameron, Kenneth L.
TI Simple Method of Glenoid Bone Loss Calculation Using Ipsilateral
Magnetic Resonance Imaging
SO AMERICAN JOURNAL OF SPORTS MEDICINE
LA English
DT Article
DE shoulder instability; bone loss; MRI; surgery
ID ANTERIOR SHOULDER INSTABILITY; DEFECTS; HISTORY
AB Background: Current methods for estimating glenoid bone loss in patients with chronic shoulder instability include computed tomography imaging with 3-dimensional reconstruction, specialized computer software, and imaging of the contralateral shoulder. An ideal method of glenoid measurement would require only magnetic resonance imaging (MRI) of the injured shoulder.
Purpose: To determine whether MRI measurement of glenoid height, as well as sex, could be used to estimate glenoid width in healthy subjects with no history of shoulder instability.
Study Design: Cross-sectional study; Level of evidence, 3.
Methods: Bilateral shoulder MRIs were obtained in a healthy cohort of young athletes as part of the baseline assessment in a prospective cohort study. A musculoskeletal radiologist measured glenoid height and width using the sagittal MRI cuts. Univariate and multivariate regression analyses were performed to determine whether demographic and MRI measurements of the glenoid could be used to estimate glenoid width.
Results: Of the 1264 shoulder MRIs evaluated, the mean glenoid width was 26.67 mm (+/- 2.49 mm), and the mean glenoid height was 42.15 mm (+/- 3.00 mm). There were significant differences between the 129 female glenoids and the 1035 male glenoids for both width (23.1 mm, 27.1 mm, respectively, P < .0001) and height (37.9 mm, 42.7 mm, respectively, P < .0001); however, the relationship between glenoid height and width was similar for both men and women. The glenoid width was found to correlate with the height measurement (r = 0.56) for the entire cohort. Based on the results of linear regression analysis, controlling for the influence of sex, a formula was created that represents the relationship between these variables for male subjects: GlenoidWidth = (1/3 Height) + 15 mm. Female patients are estimated with a formula that represents the same slope but a different intercept: W = 1/3 H + 13 mm.
Conclusion: Significant differences in glenoid height and width were found by sex; however, the relationship between height and width was similar. These variables are correlated, and the resultant formula can be used to estimate the expected glenoid width in a patient with bone loss. This formula allows for easy calculation of the amount of glenoid bone loss with only a ruler and an MRI of the injured shoulder.
C1 [Owens, Brett D.; Burns, Travis C.; Campbell, Scot E.; Svoboda, Steven J.; Cameron, Kenneth L.] US Mil Acad, Keller Army Hosp, West Point, NY 10996 USA.
RP Owens, BD (reprint author), Keller Army Hosp, West Point, NY 10996 USA.
EM b.owens@us.army.mil
OI Cameron, Kenneth/0000-0002-6276-4482
FU Orthopaedic Research and Education Foundation
FX One or more of the authors has declared the following potential conflict
of interest or source of funding: This study was supported by a
prospective research grant from the Orthopaedic Research and Education
Foundation.
NR 11
TC 6
Z9 7
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0363-5465
J9 AM J SPORT MED
JI Am. J. Sports Med.
PD MAR
PY 2013
VL 41
IS 3
BP 622
EP 624
DI 10.1177/0363546512472325
PG 3
WC Orthopedics; Sport Sciences
SC Orthopedics; Sport Sciences
GA 098QG
UT WOS:000315563200020
PM 23339835
ER
PT J
AU Dees, RA
Nestler, ST
Kewley, R
AF Dees, Robert A.
Nestler, Scott T.
Kewley, Robert
TI WholeSoldier Performance Appraisal to Support Mentoring and Personnel
Decisions
SO DECISION ANALYSIS
LA English
DT Article
DE value-focused thinking; performance appraisal; mentoring; personnel
decisions; applications: military; practice
ID BALANCED SCORECARD
AB We present a multiattribute model called Whole Soldier Performance that measures the performance of junior enlisted soldiers in the U.S. Army; currently there is no formal performance appraisal system in place. The application is unique to decision analysis in that we utilize a common constructed scale and single-dimensional value function for all attributes to match the natural framework of model users and based on operability concerns. Additionally, we discuss model validation in both the terms of decision analysis and psychometrics in models that are used for repeated or routine assessments and thus generate significant quantities of data. We highlight visualization of data for use to support mentoring and personnel decisions to better train, assign, retain, promote, and separate current personnel. Last, we address common cultural concerns related to performance appraisals in organizations by offering a method to standardize ratings and hold raters accountable for their responsibility to mentor subordinates as well as identify their performance to the larger organization.
C1 [Dees, Robert A.] Univ Texas Austin, McCombs Sch Business, Austin, TX 78712 USA.
[Nestler, Scott T.] USN, Postgrad Sch, Dept Operat Res, Monterey, CA 93943 USA.
[Kewley, Robert] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA.
RP Dees, RA (reprint author), Univ Texas Austin, McCombs Sch Business, Austin, TX 78712 USA.
EM rob.dees@utexas.edu; scott.nestler@gmail.com; robert.kewley@usma.edu
NR 29
TC 2
Z9 2
U1 1
U2 18
PU INFORMS
PI HANOVER
PA 7240 PARKWAY DR, STE 310, HANOVER, MD 21076-1344 USA
SN 1545-8490
J9 DECIS ANAL
JI Decis. Anal.
PD MAR
PY 2013
VL 10
IS 1
BP 82
EP 97
DI 10.1287/deca.1120.0263
PG 16
WC Management
SC Business & Economics
GA 098HJ
UT WOS:000315539600006
ER
PT J
AU Shen-Gunther, J
Rebeles, J
AF Shen-Gunther, Jane
Rebeles, Jennifer
TI Genotyping human papillomaviruses: Development and evaluation of a
comprehensive DNA microarray
SO GYNECOLOGIC ONCOLOGY
LA English
DT Article
DE HPV; HPV genotyping; HPV microarray; HPV molecular detection; DNA
microarray
ID SPECIMENS
AB Goals. To define the analytical and clinical performance of a human papillomavirus (HPV) custom-designed microarray targeting the HPV L1 gene for viral genotyping.
Methods. Microarray probes were designed by cataloging the genome sequence of all 120 known HPV types to generate tiling probes using eArray (R) software against the unique L1 capsid gene segments targeted by MY09/11 and FAP59/64 primers. The microarray (1 slide x 8 arrays x 60 K features) synthesized in situ by inkjet printing was tested using synthetic type-specific HPV DNA and existing HPV DNA from cervical cytology. The synthetic HPV L1 segments (genotypes 6, 11, 16, 18, 31, 33, 35, 45, 53, 58, 66, 73, 83) were manufactured from sequences stored in the NCBI taxonomy database. Using the hybridization patterns of the synthetic HPV DNA as the Support Vector Machine classifier, HPV DNA from patient samples were genotyped and compared to antecedent DNA sequencing/BLAST (R) results for concordance.
Results. 16 cytology-derived HPV DNA samples and 13 synthetic type-specific HPV DNA samples were tested singly, in duplicate, or in combination on 40 arrays. The synthetic HPV DNA hybridization patterns were found to be uniquely distinctive to serve well as a classifier of unknown HPV-containing specimens. For the 16 HPV DNA+ samples classified, 15 were concordant with DNA sequencing results. In 6/16 (38%) samples, the microarray hybridization pattern revealed >= 2 concurrent HPV infections.
Conclusion. The novel "HPV Array" was sensitive and specific for detecting single and multiple infections. This proof-of-principle project demonstrated the accuracy and advantages of microarray technology for HPV genotyping. Published by Elsevier Inc.
C1 [Shen-Gunther, Jane] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA.
[Rebeles, Jennifer] Greehey Childrens Canc Res Inst, San Antonio, TX 78228 USA.
RP Shen-Gunther, J (reprint author), Brooke Army Med Ctr, Dept Clin Invest, ATTN MCHE CI, 3400 Rawley E Chambers Ave,Ste A, Ft Sam Houston, TX 78234 USA.
EM jane.shengunther@us.army.mil; rebeles@live.unc.edu
FU CTSA grant [UL1TR000149]; CTSA grant from the University of Texas Health
Sciences Center at San Antonio, San Antonio, Texas [UL1TR000149];
National Institute on Minority Health and Health Disparities from the
National Institutes of Health [G12MD007591]
FX This study was supported in part by a CTSA grant (UL1TR000149).; This
work was supported in part by a CTSA grant (UL1TR000149) from the
University of Texas Health Sciences Center at San Antonio, San Antonio,
Texas. Agilent Technologies provided 3 microarrays via a Material
Transfer Agreement. GeneSpring GX software support was provided by the
Computational System Biology Core at University of Texas at San Antonio,
funded by the National Institute on Minority Health and Health
Disparities (G12MD007591) from the National Institutes of Health.
NR 24
TC 5
Z9 5
U1 0
U2 13
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0090-8258
J9 GYNECOL ONCOL
JI Gynecol. Oncol.
PD MAR
PY 2013
VL 128
IS 3
BP 433
EP 441
DI 10.1016/j.ygyno.2012.11.028
PG 9
WC Oncology; Obstetrics & Gynecology
SC Oncology; Obstetrics & Gynecology
GA 095FU
UT WOS:000315320900006
PM 23200917
ER
PT J
AU Taylor, KF
Lanzi, JT
Cage, JM
Drake, ML
AF Taylor, Kenneth F.
Lanzi, Joseph T.
Cage, J. Matthew
Drake, Matthew L.
TI Radial Collateral Ligament Injuries of the Thumb Metacarpophalangeal
Joint: Epidemiology in a Military Population
SO JOURNAL OF HAND SURGERY-AMERICAN VOLUME
LA English
DT Article
DE Radial collateral ligament; thumb; instability
ID INSTABILITY; ANCHOR; REPAIR
AB Purpose The reasons for variation in the reported incidence rates between thumb metacarpophalangeal joint radial collateral ligament (RCL) and ulnar collateral ligament (UCL) injuries are unclear. Delay in diagnosis of injury to the RCL leads to greater time of patient disability. The purpose of this study was to define the demographics and presentation of patients with RCL injuries in a military health care system.
Methods We performed a retrospective review of electronic medical records over a 5-year period to determine the incidence and epidemiology related to patients with instability of the thumb metacarpophalangeal joint resulting from injury of the radial or ulnar collateral ligaments.
Results A total of 56 patients presented with thumb metacarpophalangeal joint instability. Of these, 18 (32%) had an RCL injury. Patients with an RCL injury were, on average, younger than those with UCL injuries. Those with RCL injuries were more likely to require surgery than were those with UCL injuries (67% vs 40%). With regard to time to presentation, most patients with UCL injuries presented 2 to 10 weeks after injury, whereas nearly all patients with RCL injuries presented greater than 10 weeks after injury. Radial collateral ligament injuries were more likely than UCL injuries to have resulted from an axial load (56% vs 16%), whereas UCL injuries were more likely to have been caused by an abduction-adduction moment (50% vs 22%).
Conclusions In this series, patients sustaining injuries to the RCL were younger and presented later than their counterparts with UCL instability. Close attention to subtle or frank instability presenting as pain in younger patients with axial loading injury mechanisms may allow early diagnosis and appropriate treatment of this injury. (J Hand Surg 2013;38A:532-536. Copyright (C) 2013 by the American Society for Surgery of the Hand. All rights reserved.)
C1 [Taylor, Kenneth F.; Lanzi, Joseph T.; Cage, J. Matthew; Drake, Matthew L.] Tripler Army Med Ctr, Orthopaed Surg Serv, Honolulu, HI 96859 USA.
RP Taylor, KF (reprint author), Penn State Milton S Hershey Med Ctr, Dept Orthopaed & Rehabil, 30 Hope Dr, Hershey, PA 17033 USA.
EM ktaylor3@hmc.psu.edu
NR 20
TC 3
Z9 4
U1 0
U2 4
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0363-5023
J9 J HAND SURG-AM
JI J. Hand Surg.-Am. Vol.
PD MAR
PY 2013
VL 38A
IS 3
BP 532
EP 536
DI 10.1016/j.jhsa.2012.12.003
PG 5
WC Orthopedics; Surgery
SC Orthopedics; Surgery
GA 099XW
UT WOS:000315660200015
PM 23375785
ER
PT J
AU Aslan, M
Concato, J
Peduzzi, PN
Proctor, SP
Schnurr, PP
Marx, BP
McFall, M
Gleason, T
Huang, GD
Vasterling, JJ
AF Aslan, Mihaela
Concato, John
Peduzzi, Peter N.
Proctor, Susan P.
Schnurr, Paula P.
Marx, Brian P.
McFall, Miles
Gleason, Theresa
Huang, Grant D.
Vasterling, Jennifer J.
TI Design of "Neuropsychological and Mental Health Outcomes of Operation
Iraqi Freedom: A Longitudinal Cohort Study''
SO JOURNAL OF INVESTIGATIVE MEDICINE
LA English
DT Article
DE posttraumatic stress disorders; brain injuries; traumatic;
neuropsychological tests; closed cohort studies; methods
ID ADMINISTERED PTSD SCALE; CES-D; DEPLOYMENT; PERSONNEL; VETERANS; WAR
AB Objective: This study aimed to describe methodological challenges encountered in designing a follow-up assessment of US Army Soldiers who served in Operation Iraqi Freedom.
Study Design and Setting: The Neurocognition Deployment Health Study (NDHS) enrolled 1595 soldiers at 2 military installations, starting in 2003. Prior work compared predeployment and postdeployment assessments among Iraq-deployed and nondeployed soldiers. The current phase, as VA Cooperative Studies Program #566, is collecting follow-up data on participants who were deployed to Iraq or Afghanistan. Specific aims include evaluating the prevalence and course of posttraumatic stress disorder (PTSD), the persistence of previously observed neuropsychological changes, and the relationship of these changes-and traumatic brain injury-to subsequent PTSD. The target sample size is 817 participants, with 200 participants also receiving performance-based neuropsychological assessments.
Results: We describe 6 methodological challenges and their implications for longitudinal research among a "closed,'' young, mobile study population: transitioning from cluster-based (battalion) sampling to individual-level sampling; overcoming practical barriers (such as location searches); selecting exposure and outcome measures that combine previously collected and current study data; accounting for loss of an exposed (deployed) versus (nonexposed) nondeployed comparison; determining timing of assessments; and developing a complex statistical analysis plan. Enrollment is ongoing.
Conclusions: The study provides unique insights regarding elements of study design and analysis that are relevant to longitudinal research. In particular, the dynamic "real-life'' context of military deployment provides a basis for applying observational methodology to characterize mental health disorders associated with exposure to war-zone deployment and other contexts associated with exposure to extreme stress.
C1 [Aslan, Mihaela; Concato, John] VA Connecticut Healthcare Syst, Clin Epidemiol Res Ctr, West Haven, CT 06516 USA.
[Aslan, Mihaela; Concato, John] Yale Univ, Sch Med, Dept Med, New Haven, CT 06510 USA.
[Peduzzi, Peter N.] Yale Univ, Yale Ctr Analyt Sci, New Haven, CT USA.
[Peduzzi, Peter N.] Yale Univ, Sch Publ Hlth, New Haven, CT USA.
[Proctor, Susan P.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA.
[Proctor, Susan P.] VA Boston Healthcare Syst, Res Serv, Boston, MA USA.
[Proctor, Susan P.] USA, Environm Med Res Inst, Natick, MA 01760 USA.
[Schnurr, Paula P.] Geisel Sch Med Dartmouth, Dept Psychiat, Hanover, NH USA.
[Schnurr, Paula P.] White River Junction VA Med Ctr, VA Natl Ctr Posttraumat Stress Disorder PTSD, White River Jct, VT USA.
[Marx, Brian P.; Vasterling, Jennifer J.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA.
[Marx, Brian P.; Vasterling, Jennifer J.] VA Boston Healthcare Syst, Psychol Serv, Boston, MA USA.
[Marx, Brian P.; Vasterling, Jennifer J.] VA Boston Healthcare Syst, Natl Ctr PTSD, Boston, MA USA.
[McFall, Miles] Univ Washington, Sch Med, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA.
[McFall, Miles] VA Puget Sound Healthcare Syst, Seattle, WA USA.
[Gleason, Theresa; Huang, Grant D.] US Dept Vet Affairs, Off Res & Dev, NW, Washington, DC USA.
RP Aslan, M (reprint author), VA Connecticut Healthcare Syst, Clin Epidemiol Res Ctr, 950 Campbell Ave,Mailcode 151B, West Haven, CT 06516 USA.
EM mihaela.aslan@va.gov
FU Department of Veterans Affairs Cooperative Studies Program; Abt SRBI,
Inc.
FX Supported by the Department of Veterans Affairs Cooperative Studies
Program.; The authors thank all the participants in this study.
Participants are enrolled by staff at sites in Boston and Seattle, with
specific services provided via a contract with Abt SRBI, Inc. The study
is managed by the CSP #566 Chair's office at the Boston VA Healthcare
System, the VA Clinical Epidemiology Research Center (CERC) at VA
Connecticut Healthcare System in West Haven, an Executive Committee, and
a Data Monitoring Committee; the entire initiative is overseen by VA
Office of Research and Development. In addition to the authors of the
paper, the following persons have provided expertise or assistance in
the conduct of the study. Boston site: Fabiana Cabral, Meredith Charney,
May Chen, Kaitlyn Gorman, Sohyun Han, Darren Holowaka, Heather Kapson,
Amy Lawrence, Mary Alice Mills, Nicole Rodier, Paola Rodriguez, and Erin
Ulloa. Seattle site: Kate Hoerster, Matthew Jakupcak, David Slagle,
David Tice, and Ollie (Richie) Yarbrough. Chair's Office: Molly Franz,
Anna Graefe, and Helen MacDonald. West Haven CERC and CSP Coordinating
Center: Margaret Antonelli, Donna Cavaliere, Patricia Crutchfield, Maria
deAsis, Peter Guarino, Adrienne Hoey, John Ko, Kathy Newvine, Susan
O'Neil, Diane Orlando, Thomas Roy, and Joseph Turner. Executive
Committee members: Paul Amoroso, Paul Bliese, Charles Hoge, and Theresa
O'Connor. Data Monitoring Committee: Haiqun Lin, Scott Orr, Margaret
Ryan, Karen Schwab, and Ayumi Shintani. VA Central Office: Timothy
O'Leary. CSP Clinical Research Pharmacy Coordinating Center (CSPCRPCC):
Clair Haakenson, Darlene Krueger, Amanda Snodgrass, and Kathleen Swanson
[Site Monitoring, Auditing and Review Team (SMART)].
NR 28
TC 1
Z9 1
U1 1
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1081-5589
J9 J INVEST MED
JI J. Invest. Med.
PD MAR
PY 2013
VL 61
IS 3
BP 569
EP 577
DI 10.231/JIM.0b013e31828407ff
PG 9
WC Medicine, General & Internal; Medicine, Research & Experimental
SC General & Internal Medicine; Research & Experimental Medicine
GA 097GU
UT WOS:000315462800012
PM 23392054
ER
PT J
AU Ahmed, SI
Burns, TC
Landt, C
Hayda, R
AF Ahmed, Syed I.
Burns, Travis C.
Landt, Cristy
Hayda, Roman
TI Heterotopic Ossification in High-Grade Open Fractures Sustained in
Combat: Risk Factors and Prevalence
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE heterotopic ossification; open fracture; war; combat
ID TRAUMATIC BRAIN-INJURY; TOTAL HIP-ARTHROPLASTY; BONE-FORMATION; ECTOPIC
OSSIFICATION; ORTHOPEDIC INJURIES; OPERATIVE TREATMENT; KNEE
DISLOCATION; PROGENITOR CELLS; CALLUS FORMATION; SEVERITY SCORE
AB Objectives: To determine the prevalence and identify the risk factors for heterotopic ossification (HO) formation in high-grade open fractures sustained during combat and to report on the results of HO excision.
Design: Retrospective.
Setting: United States Army level-1 trauma center.
Patients/Participants: Seventy-six consecutive patients with 91 combat-related open Gustilo and Anderson type II and higher fractures were identified from March 1, 2003, through January 30, 2005. Fifty-nine patients with 71 fractures met criteria for study inclusion.
Main Outcome Measurements: Fractures were categorized into HO-present and HO-absent groups based on radiographic imaging. Risk factors such as injury mechanism, injury severity score (ISS), Gustilo and Anderson type, injury location, closed head injury, burn, and infection were compared between the groups.
Results: HO was present in 27 of 71 open fractures (38.1%). Variables associated with HO formation included ISS (p = 0.02) and injury location although infection and use of negative pressure therapy were not. Ten of 27 fractures with HO underwent excision. HO did not occur or was mild in 25 tibiae.
Conclusions: HO is a common sequela of high-grade open fractures sustained in combat. High ISS and injury location to the shoulder, hip, and femur are risk factors for HO formation. The most common regions for HO excision were the elbow, forearm, and hip with mixed results. Importantly, HO did not seem to be a complication of open high-grade tibia fractures.
C1 [Ahmed, Syed I.] Landstuhl Reg Med Ctr, Dept Orthopaed Surg, Landstuhl, Germany.
[Burns, Travis C.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA.
[Landt, Cristy] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA.
[Hayda, Roman] Brown Univ, Rhode Isl Hosp, Warren Alpert Sch Med, Div Orthoped Trauma, Providence, RI 02903 USA.
RP Ahmed, SI (reprint author), Med Corps, CMR 402 Box 636, Apo, AE 09180 USA.
EM ahmedi01@yahoo.com
NR 60
TC 3
Z9 4
U1 1
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0890-5339
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD MAR
PY 2013
VL 27
IS 3
BP 162
EP 169
DI 10.1097/BOT.0b013e31825cf742
PG 8
WC Orthopedics; Sport Sciences
SC Orthopedics; Sport Sciences
GA 098CD
UT WOS:000315521400013
PM 22584683
ER
PT J
AU Palacios, G
Savji, N
da Rosa, AT
Guzman, H
Yu, XJ
Desai, A
Rosen, GE
Hutchison, S
Lipkin, WI
Tesh, R
AF Palacios, Gustavo
Savji, Nazir
da Rosa, Amelia Travassos
Guzman, Hilda
Yu, Xuejie
Desai, Aaloki
Rosen, Gail Emilia
Hutchison, Stephen
Lipkin, W. Ian
Tesh, Robert
TI Characterization of the Uukuniemi Virus Group (Phlebovirus:
Bunyaviridae): Evidence for Seven Distinct Species
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID VALLEY FEVER VIRUS; HANTAVIRUS-PULMONARY-SYNDROME; M-SEGMENT
REASSORTMENT; HIDDEN MARKOV MODEL; GENETIC-CHARACTERIZATION; MOLECULAR
EPIDEMIOLOGY; FAMILY BUNYAVIRIDAE; COMPLETE GENOMES; OROPOUCHE VIRUS;
NSM PROTEINS
AB Evolutionary insights into the phleboviruses are limited because of an imprecise classification scheme based on partial nucleotide sequences and scattered antigenic relationships. In this report, the serologic and phylogenetic relationships of the Uukuniemi group viruses and their relationships with other recently characterized tick-borne phleboviruses are described using full-length genome sequences. We propose that the viruses currently included in the Uukuniemi virus group be assigned to five different species as follows: Uukuniemi virus, EgAn 1825-61 virus, Fin V707 virus, Chize virus, and Zaliv Terpenia virus would be classified into the Uukuniemi species; Murre virus, RML-105-105355 virus, and Sunday Canyon virus would be classified into a Murre virus species; and Grand Arbaud virus, Precarious Point virus, and Manawa virus would each be given individual species status. Although limited sequence similarity was detected between current members of the Uukuniemi group and Severe fever with thrombocytopenia syndrome virus (SFTSV) and Heartland virus, a clear serological reaction was observed between some of them, indicating that SFTSV and Heartland virus should be considered part of the Uukuniemi virus group. Moreover, based on the genomic diversity of the phleboviruses and given the low correlation observed between complement fixation titers and genetic distance, we propose a system for classification of the Bunyaviridae based on genetic as well as serological data. Finally, the recent descriptions of SFTSV and Heartland virus also indicate that the public health importance of the Uukuniemi group viruses must be reevaluated.
C1 [Palacios, Gustavo] USA, Med Res Inst Infect Dis, Ctr Genom Sci, Frederick, MD USA.
[Savji, Nazir; Desai, Aaloki; Rosen, Gail Emilia; Lipkin, W. Ian] Columbia Univ, Mailman Sch Publ Hlth, Ctr Infect & Immun, New York, NY USA.
[da Rosa, Amelia Travassos; Guzman, Hilda; Yu, Xuejie; Tesh, Robert] Univ Texas Med Branch, Dept Pathol, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 USA.
[Hutchison, Stephen] 454 Roche Life Sci, Branford, CT USA.
RP Palacios, G (reprint author), USA, Med Res Inst Infect Dis, Ctr Genom Sci, Frederick, MD USA.
EM gustavo.f.palacios.ctr@us.army.mil
RI Palacios, Gustavo/I-7773-2015
OI Palacios, Gustavo/0000-0001-5062-1938
FU Google.org; National Institutes of Health [AI57158]; USAID PREDICT
[07-301-7119-52258]; Defense Threat Reduction Agency; U.S. Department of
Defense; NIH [HHSN272201000040I/HHSN27200004/DO4]
FX This work was supported by Google.org, National Institutes of Health
award AI57158 (Northeast Biodefense Center-Lipkin), USAID PREDICT
funding source code 07-301-7119-52258 (Center for Infection and
Immunity), the Defense Threat Reduction Agency, and the U.S. Department
of Defense. R.T., A.T.D.R., X.Y., and H.G. were supported by NIH
contract HHSN272201000040I/HHSN27200004/DO4.
NR 69
TC 29
Z9 36
U1 0
U2 15
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD MAR
PY 2013
VL 87
IS 6
BP 3187
EP 3195
DI 10.1128/JVI.02719-12
PG 9
WC Virology
SC Virology
GA 095QD
UT WOS:000315348500019
PM 23283959
ER
PT J
AU Singh, J
Im, J
Watters, EJ
Whitten, JE
Soares, JW
Steeves, DM
AF Singh, Jagdeep
Im, Jisun
Watters, Evan J.
Whitten, James E.
Soares, Jason W.
Steeves, Diane M.
TI Thiol dosing of ZnO single crystals and nanorods: Surface chemistry and
photoluminescence
SO SURFACE SCIENCE
LA English
DT Article
DE Adsorption; Photoemission; Photoluminescence; Raman spectroscopy; Thiol;
Work function; Zinc oxide
ID ZINC-OXIDE SURFACES; WORK FUNCTION; ADSORPTION; (CH3)(2)S-2; CH3SH; GOLD
AB Adsorption of thiols on ZnO(0001) and ZnO nanorods has been investigated using X-ray and ultraviolet photoelectron spectroscopies (XPS and UPS). Ultrahigh vacuum (UHV) dosing of sputter-cleaned ZnO(0001) with methanethiol (MT), 1-dodecanethiol (DDT), and 3-mercaptopropyltrimethoxysilane (MPTMS) leads to S2p peaks with a binding energy of 163.3 eV. Similar results for MPTMS are obtained for sputter-cleaned ZnO(0001) that is pre-dosed with water to form hydroxyl groups. In all cases, the absence of a free thiol S2p peak at 164.2 eV indicates that bonding to the surface occurs via the thiol end of the molecule. A DDT-dosed ZnO(0001) sample stored for 10 days in UHV and heated to temperatures as high as 150 degrees C exhibits minimal changes in its S/Zn atomic ratio, confirming chemisorption and the presence of a strong bond to the surface. UPS shows that MT adsorption on sputtered ZnO(0001) leads to a 0.7 eV increase in work function and perturbation of the MT molecular orbitals, again consistent with chemisorption. Dry ZnO nanorods have been exposed to MT while monitoring their photoluminescence. XPS and Raman spectroscopy confirm thiol adsorption. Relative to thy ZnO, adsorption causes a decrease in intensity of the visible emission peak, but the UV peak remains unchanged. These results indicate that Zn-S bond formation quenches radiative decay to the valence band from defect states, possibly by methanethiolate adsorption filling oxygen vacancies. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Singh, Jagdeep; Im, Jisun; Watters, Evan J.; Whitten, James E.] Univ Massachusetts Lowell, Dept Chem, Lowell, MA 01854 USA.
[Singh, Jagdeep; Im, Jisun; Watters, Evan J.; Whitten, James E.] Univ Massachusetts Lowell, Ctr Adv Mat, Lowell, MA 01854 USA.
[Singh, Jagdeep; Im, Jisun; Watters, Evan J.; Whitten, James E.] Univ Massachusetts Lowell, Ctr High Rate Nanomfg, Lowell, MA 01854 USA.
[Soares, Jason W.; Steeves, Diane M.] USA, Natick Res Dev & Engn Ctr, Natick, MA 01760 USA.
RP Whitten, JE (reprint author), Univ Massachusetts Lowell, Dept Chem, Lowell, MA 01854 USA.
EM james_Whitten@uml.edu; diane.m.steeves.civ@mail.mil
FU US Army Natick Soldier Research, Development and Engineering Center
[W911QY-10-2-0001]
FX This work was supported by the US Army Natick Soldier Research,
Development and Engineering Center under contract # W911QY-10-2-0001.
This document has been approved for unlimited distribution.
NR 25
TC 13
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U1 4
U2 61
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0039-6028
J9 SURF SCI
JI Surf. Sci.
PD MAR
PY 2013
VL 609
BP 183
EP 189
DI 10.1016/j.susc.2012.12.006
PG 7
WC Chemistry, Physical; Physics, Condensed Matter
SC Chemistry; Physics
GA 099GJ
UT WOS:000315609200030
ER
PT J
AU Harris, RD
Javitt, MC
Glanc, P
Brown, DL
Dubinsky, T
Harisinghani, MG
Khati, NJ
Kim, YB
Mitchell, DG
Pandharipande, PV
Pannu, HK
Podrasky, AE
Royal, HD
Shipp, TD
Siegel, CL
Simpson, L
Wall, DJ
Wong-You-Cheong, JJ
Zelop, CM
AF Harris, Robert D.
Javitt, Marcia C.
Glanc, Phyllis
Brown, Douglas L.
Dubinsky, Theodore
Harisinghani, Mukesh G.
Khati, Nadia J.
Kim, Young Bae
Mitchell, Donald G.
Pandharipande, Pari V.
Pannu, Harpreet K.
Podrasky, Ann E.
Royal, Henry D.
Shipp, Thomas D.
Siegel, Cary Lynn
Simpson, Lynn
Wall, Darci J.
Wong-You-Cheong, Jade J.
Zelop, Carolyn M.
TI ACR Appropriateness Criteria (R) Clinically Suspected Adnexal Mass
SO ULTRASOUND QUARTERLY
LA English
DT Article
DE appropriateness criteria; color doppler sonography; transvaginal
ultrasound; adnexal masses; ovarian cysts; ovarian malignancy
ID 3-DIMENSIONAL POWER DOPPLER; LOGISTIC-REGRESSION MODELS; OVARIAN-CANCER;
POSTMENOPAUSAL WOMEN; DIFFERENTIAL-DIAGNOSIS; SONOGRAPHIC FINDINGS;
PELVIC MASSES; GRAY-SCALE; CA 125; ULTRASOUND
AB Adnexal masses are a common problem clinically and imaging-wise, and transvaginal US (TVUS) is the first-line imaging modality for assessing them in the vast majority of patients. The findings of US, however, should be correlated with the history and laboratory tests, as well as any patient symptoms. Simple cysts are uniformly benign, and most warrant no further interrogation or treatment. Complex cysts carry more significant implications, and usually engender serial ultrasound(s), with a minority of cases warranting a pelvic MRI.
Morphological analysis of adnexal masses with gray-scale US can help narrow the differential diagnosis. Spectral Doppler analysis has not proven useful in most well-performed studies. However, the use of color Doppler sonography adds significant contributions to differentiating between benign and malignant masses and is recommended in all cases of complex masses. Malignant masses generally demonstrate neovascularity, with abnormal branching vessel morphology. Optimal sonographic evaluation is achieved by using a combination of gray-scale morphologic assessment and color or power Doppler imaging to detect flow within any solid areas.
The ACR Appropriateness Criteria (R) are evidence-based guidelines for specific clinical conditions that are reviewed every two years by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current medical literature from peer reviewed journals and the application of a well-established consensus methodology (modified Delphi) to rate the appropriateness of imaging and treatment procedures by the panel. In those instances where evidence is lacking or not definitive, expert opinion may be used to recommend imaging or treatment.
C1 [Harris, Robert D.] Dartmouth Hitchcock Med Ctr, Lebanon, NH 03766 USA.
[Javitt, Marcia C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
[Glanc, Phyllis] Sunnybrook Hlth Sci Ctr, Toronto, ON M4N 3M5, Canada.
[Brown, Douglas L.; Wall, Darci J.] Mayo Clin, Rochester, MN USA.
[Dubinsky, Theodore] Univ Washington, Sch Med, Seattle, WA USA.
[Harisinghani, Mukesh G.] Massachusetts Gen Hosp, Boston, MA 02114 USA.
[Khati, Nadia J.] George Washington Univ Hosp, Washington, DC USA.
[Kim, Young Bae] Tufts Med Ctr, Boston, MA USA.
[Kim, Young Bae] Soc Gynecol Oncologists, Chicago, IL USA.
[Mitchell, Donald G.] Thomas Jefferson Univ Hosp, Philadelphia, PA 19107 USA.
[Pandharipande, Pari V.] Massachusetts Gen Hosp, Boston, MA 02114 USA.
[Pannu, Harpreet K.] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA.
[Podrasky, Ann E.] Baptist Hosp Miami, South Miami Ctr Women & Infants, Miami, FL USA.
[Royal, Henry D.; Siegel, Cary Lynn] Washington Univ, Med Ctr, Mallinckrodt Inst Radiol, St Louis, MO 63110 USA.
[Royal, Henry D.] Soc Nucl Med, Reston, VA 20190 USA.
[Shipp, Thomas D.] Brigham & Womens Hosp, Boston, MA 02115 USA.
[Shipp, Thomas D.; Simpson, Lynn; Zelop, Carolyn M.] Amer Coll Obstetricians & Gynecologists, Boston, MA USA.
[Simpson, Lynn] Columbia Univ, New York, NY USA.
[Wong-You-Cheong, Jade J.] Univ Maryland, Sch Med, Baltimore, MD 21201 USA.
[Zelop, Carolyn M.] Valley Hosp, Ridgewood, NJ USA.
RP Harris, RD (reprint author), Dartmouth Hitchcock Clin, Dept Radiol, 1 Med Ctr Dr, Lebanon, NH 03756 USA.
EM rdh@hitchcock.org
NR 45
TC 5
Z9 5
U1 1
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0894-8771
J9 ULTRASOUND Q
JI Ultrasound Q.
PD MAR
PY 2013
VL 29
IS 1
BP 79
EP 86
DI 10.1097/RUQ.0b013e3182814d9b
PG 8
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA 097BQ
UT WOS:000315449400010
PM 23358212
ER
PT J
AU Indest, KJ
Hancock, DE
Jung, CM
Eberly, JO
Mohn, WW
Eltis, LD
Crocker, FH
AF Indest, Karl J.
Hancock, Dawn E.
Jung, Carina M.
Eberly, Jed O.
Mohn, William W.
Eltis, Lindsay D.
Crocker, Fiona H.
TI Role of Nitrogen Limitation in Transformation of RDX
(Hexahydro-1,3,5-Trinitro-1,3,5-Triazine) by Gordonia sp Strain KTR9
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID ANAEROBIC BIODEGRADATION; DEGRADATION; EXPRESSION; GLNR; METABOLISM;
BACTERIA; INSIGHTS; HYDROGEN; REGULON; GENES
AB The transcriptome of RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine)-degrading strain Gordonia sp. strain KTR9 and its glnR mutant were studied as a function of nitrogen availability to further investigate the observed ammonium- mediated inhibition of RDX degradation. The results indicate that nitrogen availability is a major determinant of RDX degradation and xplA gene expression in KTR9.
C1 [Indest, Karl J.; Hancock, Dawn E.; Jung, Carina M.; Eberly, Jed O.; Crocker, Fiona H.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.
[Mohn, William W.; Eltis, Lindsay D.] Univ British Columbia, Dept Microbiol & Immunol, Inst Life Sci, Vancouver, BC V5Z 1M9, Canada.
RP Indest, KJ (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.
EM Karl.J.Indest@usace.army.mil
RI Eltis, Lindsay/J-8272-2015
OI Eltis, Lindsay/0000-0002-6774-8158
FU U.S. Army Corps of Engineers Environmental Quality Research Program;
Strategic Environmental Research and Development Program [ER-1609];
Genome BC
FX This research was funded in part by the U.S. Army Corps of Engineers
Environmental Quality Research Program, the Strategic Environmental
Research and Development Program (Project ER-1609), and Genome BC.
NR 32
TC 8
Z9 9
U1 2
U2 12
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD MAR
PY 2013
VL 79
IS 5
BP 1746
EP 1750
DI 10.1128/AEM.03905-12
PG 5
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA 089ES
UT WOS:000314893300041
PM 23275513
ER
PT J
AU Walter, TR
Subhash, G
Sankar, BV
Song, MC
Yen, CF
AF Walter, T. R.
Subhash, G.
Sankar, B. V.
Song, M. C.
Yen, C. F.
TI A Novel Method for Dynamic Short-Beam Shear Testing of 3D Woven
Composites
SO EXPERIMENTAL MECHANICS
LA English
DT Article
DE High strain rate testing; Hopkinson pressure bar; 3D woven composites;
Interlaminar shear strength; Short beam shear
ID VELOCITY IMPACT DAMAGE; WEAVE GRAPHITE/EPOXY COMPOSITES;
ELEVATED-TEMPERATURES; INTERLAMINAR FRACTURE; INDENTATION RESPONSE;
BEHAVIOR; DELAMINATION; COMPRESSION; CERAMICS; STRENGTH
AB A new test method for performing dynamic short-beam shear tests using a momentum trapped Hopkinson pressure bar is proposed. Angle-interlock 3D woven composite specimens were tested under quasi-static and dynamic loading conditions to determine the effect of loading rate on damage evolution. The equilibrium condition in the composite specimen under dynamic loads was verified using finite element analysis of the experiment. A high speed camera was used to capture delamination initiation and propagation during both quasi-static and dynamic experiments. Analysis of the load-deflection curves and the high speed images revealed a good correlation between the modes of damage initiation and propagation with the features in the loading response. The apparent inter-laminar shear strength and the bending stiffness increased with rate of loading. While the damage was observed to propagate at a relative steady rate during quasi-static loading, the high rate of energy input during dynamic loading resulted in a rapid propagation of damage and a subsequent loss of stiffness in the composite as noted in the load-deflection curve.
C1 [Walter, T. R.; Subhash, G.; Sankar, B. V.; Song, M. C.] Univ Florida, Gainesville, FL 32611 USA.
[Yen, C. F.] USA, Res Lab RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA.
RP Subhash, G (reprint author), Univ Florida, Gainesville, FL 32611 USA.
EM subhash@ufl.edu
RI Walter, Thomas/K-4857-2015;
OI Sankar, Bhavani/0000-0002-4556-1982
FU United States Army Research Office [W911NF-08-1-0120]
FX The authors sincerely acknowledge the United States Army Research Office
for providing funding for this work (grant number W911NF-08-1-0120). The
authors also acknowledge the US Army Research Laboratory for supplying
the composite test panels.
NR 38
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U1 1
U2 27
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0014-4851
J9 EXP MECH
JI Exp. Mech.
PD MAR
PY 2013
VL 53
IS 3
BP 493
EP 503
DI 10.1007/s11340-012-9659-4
PG 11
WC Materials Science, Multidisciplinary; Mechanics; Materials Science,
Characterization & Testing
SC Materials Science; Mechanics
GA 094VH
UT WOS:000315292000015
ER
PT J
AU Beaver, JR
Jensen, DE
Casamatta, DA
Tausz, CE
Scotese, KC
Buccier, KM
Teacher, CE
Rosati, TC
Minerovic, AD
Renicker, TR
AF Beaver, John R.
Jensen, David E.
Casamatta, Dale A.
Tausz, Claudia E.
Scotese, Kyle C.
Buccier, Kristen M.
Teacher, Catherine E.
Rosati, Teodoro C.
Minerovic, Alison D.
Renicker, Thomas R.
TI Response of phytoplankton and zooplankton communities in six reservoirs
of the middle Missouri River (USA) to drought conditions and a major
flood event
SO HYDROBIOLOGIA
LA English
DT Article
DE Drought; Flood; Meroplankton; Phytoplankton; Zooplankton; Reservoirs;
Missouri River; Water residence time
ID FRESH-WATER PHYTOPLANKTON; LOWLAND RIVER; SUBTROPICAL RESERVOIR;
SEASONAL DYNAMICS; LAKE-ERIE; FOOD-WEB; BIOMASS; PLANKTON; GROWTH; MEUSE
AB We assessed if the qualitative and quantitative aspects of plankton composition in reservoirs of the middle Missouri River were influenced by hydrologic variability. Phytoplankton and zooplankton communities in six reservoirs of this highly regulated system were sampled between 2004 and 2011 during historic drought, subsequent recovery, and a 100-year flood event. The reservoir system encompasses a broad latitudinal gradient of decreasing depth, decreasing water residence time and increasing trophic state. Phytoplankton communities of the upper three reservoirs were co-dominated by planktonic and meroplanktonic diatoms during the drought, recovery, and flood periods, but the proportion of more silicified meroplanktonic diatoms increased in the lower three reservoirs as water residence time decreased. Peak phytoplankton biovolume usually occurred during spring/early summer and was associated with increased hydrologic inflows and outflows. Zooplankton biomass of the reservoir system was dominated by Daphnia spp., but all zooplankton groups decreased as inflows and outflows accelerated during the recovery and flood periods. Rotifer abundances were higher under turbulent conditions associated with dam operations. Canonical correlation analyses suggested that temperature, water residence time, station depth, and water clarity explained more variance in the structures of phytoplankton and zooplankton communities than bioavailable nutrient parameters.
C1 [Beaver, John R.; Tausz, Claudia E.; Scotese, Kyle C.; Buccier, Kristen M.; Teacher, Catherine E.; Rosati, Teodoro C.; Minerovic, Alison D.; Renicker, Thomas R.] BSA Environm Serv Inc, Beachwood, OH USA.
[Jensen, David E.] USA, Corps Engineers, Omaha, NE USA.
[Casamatta, Dale A.] Univ N Florida, Dept Biol, Jacksonville, FL USA.
RP Beaver, JR (reprint author), BSA Environm Serv Inc, Beachwood, OH USA.
EM j.beaver@bsaenv.com
NR 84
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U1 7
U2 88
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0018-8158
J9 HYDROBIOLOGIA
JI Hydrobiologia
PD MAR
PY 2013
VL 705
IS 1
BP 173
EP 189
DI 10.1007/s10750-012-1397-1
PG 17
WC Marine & Freshwater Biology
SC Marine & Freshwater Biology
GA 089BW
UT WOS:000314884800014
ER
PT J
AU Knuth, MA
Courville, ZR
AF Knuth, Margaret A.
Courville, Zoe R.
TI Proof of Concept: Firn Air Facility Cooling at Summit Station, Greenland
SO JOURNAL OF COLD REGIONS ENGINEERING
LA English
DT Article
DE Greenland; firn; refrigeration
AB A firn air cooling system that utilized the natural reservoir of cool air at depth in polar ice sheets was tested at Summit Station, Greenland during the summer of 2010. Cooling is required on station to meet the requirements for food safety and scientific core storage. Firn air cooling is a potential replacement for traditional mechanical cooling systems. The system design, installation, and results of several experiments are presented. The system cooled a 27 m(3) enclosed, insulated structure from -20 to -25 degrees C using a 10-m borehole and a fan pumping the naturally cool air. The system was easy to install in a short time frame and was low cost from an equipment and operating perspective. DOI: 10.1061/(ASCE)CR.1943-5495.0000049. (C) 2013 American Society of Civil Engineers.
C1 [Knuth, Margaret A.; Courville, Zoe R.] USA, Erdc, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
RP Knuth, MA (reprint author), USA, Erdc, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA.
EM margaret.a.knuth@usace.army.mil; zoe.r.courville@usace.army.mil
FU National Science Foundation, Office of Polar Programs-Arctic Research
Support and Logistics
FX This work was funded by the National Science Foundation, Office of Polar
Programs-Arctic Research Support and Logistics. This work could not have
been completed without the outstanding assistance received from many
CH2M Hill Polar Services (CPS)/Polar Field Services (PFS) staff and
drilling support from Ice Core Drilling Services.
NR 6
TC 0
Z9 0
U1 1
U2 9
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0887-381X
J9 J COLD REG ENG
JI J. Cold Reg. Eng.
PD MAR
PY 2013
VL 27
IS 1
BP 16
EP 28
DI 10.1061/(ASCE)CR.1943-5495.0000049
PG 13
WC Engineering, Environmental; Engineering, Civil; Geosciences,
Multidisciplinary
SC Engineering; Geology
GA 097ID
UT WOS:000315466300002
ER
PT J
AU Aguilar, A
Douglas, RB
Gordon, E
Baumsteiger, J
Goldsworthy, MO
AF Aguilar, Andres
Douglas, Robert B.
Gordon, Eric
Baumsteiger, Jason
Goldsworthy, Matthew O.
TI Elevated Genetic Structure in the Coastal Tailed Frog (Ascaphus truei)
in Managed Redwood Forests
SO JOURNAL OF HEREDITY
LA English
DT Article
DE conservation; landscape; microsatellites; timberlands
ID MULTILOCUS GENOTYPE DATA; ALLELE FREQUENCY DATA; POPULATION-STRUCTURE;
LANDSCAPE GENETICS; STREAM AMPHIBIANS; NORTHWESTERN CALIFORNIA;
DIFFERENTIATION MEASURE; HABITAT FRAGMENTATION; NORTHERN CALIFORNIA;
INCIDENT RADIATION
AB Landscape alterations have dramatic impacts on the distribution of genetic variation within and among populations and understanding these effects can guide contemporary and future conservation strategies. We initiated a landscape-scale genetic study of the coastal tailed frog (Ascaphus truei) on commercial timberlands within the southern range of the species in Mendocino County (CA, USA). In total, 294 individuals from 13 populations were analyzed at 9 microsatellite loci. None of the sampled populations departed from mutationdrift equilibrium, indicating recent population bottlenecks were not detected in contemporary samples. Fine-scale analysis indicated sampled populations were structured at the watershed level (mean F-ST 0.077 and mean G(ST) 0.425). Landscape analyses suggested wet and moist areas may serve as significant corridors for gene flow within watersheds in this region (r(2) 0.320.54 for moisture-related features). Results indicate populations of frogs may have persisted at this scale through intense periods of timber harvest, making southern range edge populations of coastal tailed frogs resilient to past land use practices.
C1 [Aguilar, Andres; Baumsteiger, Jason] Univ Calif Merced, Sch Nat Sci, Merced, CA 95344 USA.
[Aguilar, Andres; Baumsteiger, Jason] Univ Calif Merced, Sierra Nevada Res Inst, Merced, CA 95344 USA.
[Douglas, Robert B.; Goldsworthy, Matthew O.] Mendocino Redwood Co, Ft Bragg, CA 95437 USA.
[Gordon, Eric] Mendocino Redwood Co, Ukiah, CA 95482 USA.
RP Aguilar, A (reprint author), Univ Calif Merced, Sch Nat Sci, 5200 N Lake Rd, Merced, CA 95344 USA.
EM aaguilar2@ucmerced.edu
FU United States Department of Agriculture [2007-35101-18171]
FX United States Department of Agriculture(2007-35101-18171) to A.A.
NR 98
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Z9 1
U1 3
U2 57
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1503
J9 J HERED
JI J. Hered.
PD MAR-APR
PY 2013
VL 104
IS 2
BP 202
EP 216
DI 10.1093/jhered/ess138
PG 15
WC Evolutionary Biology; Genetics & Heredity
SC Evolutionary Biology; Genetics & Heredity
GA 092XI
UT WOS:000315155900005
PM 23325865
ER
PT J
AU Grujicic, M
Pandurangan, B
Snipes, JS
Yen, CF
Cheeseman, BA
AF Grujicic, M.
Pandurangan, B.
Snipes, J. S.
Yen, C. -F.
Cheeseman, B. A.
TI Multi-Length Scale-Enriched Continuum-Level Material Model for Kevlar(A
(R))-Fiber-Reinforced Polymer-Matrix Composites
SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
LA English
DT Article
DE ballistics; composites; Kevlar; material models; microstructural defects
ID LAMINATED COMPOSITES; FIBER-COMPOSITES; DAMAGE; IMPACT
AB Fiber-reinforced polymer matrix composite materials display quite complex deformation and failure behavior under ballistic/blast impact loading conditions. This complexity is generally attributed to a number of factors such as (a) hierarchical/multi-length scale architecture of the material microstructure; (b) nonlinear, rate-dependent and often pressure-sensitive mechanical response; and (c) the interplay of various intrinsic phenomena and processes such as fiber twisting, interfiber friction/sliding, etc. Material models currently employed in the computational engineering analyses of ballistic/blast impact protective structures made of this type of material do not generally include many of the aforementioned aspects of the material dynamic behavior. Consequently, discrepancies are often observed between computational predictions and their experimental counterparts. To address this problem, the results of an extensive set of molecular-level computational analyses regarding the role of various microstructural/morphological defects on the Kevlar(A (R)) fiber mechanical properties are used to upgrade one of the existing continuum-level material models for fiber-reinforced composites. The results obtained show that the response of the material is significantly affected as a result of the incorporation of microstructural effects both under quasi-static simple mechanical testing condition and under dynamic ballistic-impact conditions.
C1 [Grujicic, M.; Pandurangan, B.; Snipes, J. S.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA.
[Yen, C. -F.; Cheeseman, B. A.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA.
EM gmica@clemson.edu
FU Army Research Office (ARO) [W911NF-09-1-0513]; Army Research Laboratory
(ARL) [W911NF-06-2-0042]
FX The material presented in this article is based on research supported by
the Army Research Office (ARO) research contract entitled
"Multi-length-scale Material Model Development for Armor-grade
Composites" (Contract Number W911NF-09-1-0513) and the Army Research
Laboratory (ARL) research contract entitled "Computational Analysis and
Modeling of Various Phenomena Accompanying Detonation Explosives
Shallow-Buried in Soil" (Contract Number W911NF-06-2-0042). The authors
are indebted to Dr. Larry Russell of ARO for his continuous support and
interest during the above study.
NR 22
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PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1059-9495
J9 J MATER ENG PERFORM
JI J. Mater. Eng. Perform.
PD MAR
PY 2013
VL 22
IS 3
BP 681
EP 695
DI 10.1007/s11665-012-0329-6
PG 15
WC Materials Science, Multidisciplinary
SC Materials Science
GA 089GU
UT WOS:000314899800005
ER
PT J
AU Gregory, SM
Spiering, BA
Alemany, JA
Tuckow, AP
Rarick, KR
Staab, JS
Hatfield, DL
Kraemer, WJ
Maresh, CM
Nindl, BC
AF Gregory, Sara M.
Spiering, Barry A.
Alemany, Joseph A.
Tuckow, Alexander P.
Rarick, Kevin R.
Staab, Jeffery S.
Hatfield, Disa L.
Kraemer, William J.
Maresh, Carl M.
Nindl, Bradley C.
TI Exercise-Induced Insulin-Like Growth Factor I System Concentrations
after Training in Women
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Article
DE ENDOCRINE; FREE INSULIN-LIKE GROWTH FACTOR I; GROWTH HORMONE; ENDURANCE
TRAINING; RESISTANCE TRAINING; IGF BINDING PROTEINS
ID HEAVY-RESISTANCE EXERCISE; BONE-MINERAL DENSITY; IGF-I; SKELETAL-MUSCLE;
BINDING-PROTEIN; PHYSICAL CAPACITY; HORMONE; RESPONSES; DIFFERENTIATION;
SERUM
AB GREGORY, S. M., B. A. SPIERING, J. A. ALEMANY, A. P. TUCKOW, K. R. RARICK, J. S. STAAB, D. L. HATFIELD, W. J. KRAEMER, C. M. MARESH, and B. C. NINDL. Exercise-Induced Insulin-Like Growth Factor I System Concentrations after Training in Women. Med. Sci. Sports Exerc., Vol. 45, No. 3, pp. 420-428, 2013. Introduction: This study examined the effects of short-term physical training on the acute hormonal response (i.e., growth hormone, total and free insulin-like growth factor I [IGF-I], and IGF binding proteins [IGFBP]-1, IGFBP-2, and IGFBP-3) to resistance exercise (RE) in women. Methods: Forty-six women (20.3 +/- 0.3 yr, mass = 64.1 +/- 7.3 kg, height = 165.7 +/- 1.0 cm) were randomly assigned to an endurance training (E), resistance training (R), combined training (R + E), or control (C) group for 8 wk. Subjects completed a standardized bout of RE (six sets of back squats at 10 repetition maximum) before and after training. Blood samples were obtained at rest (PRE), after the third set, immediately postexercise (POST), and at 15 min and 30 min after exercise. Results: Acute RE significantly increased (P < 0.05) serum growth hormone (mean +/- SD; change from PRE to POST = +10.9 +/- 7.5 mu g.L-1), total IGF-I (+66.1 +/- 25.4 mu g.L-1), IGFBP-1 (+2.5 +/- 3.1 mu g.L-1), IGFBP-2 (+86.0 +/- 86.8 mu g.L-1), and IGFBP-3 (+0.69 +/- 0.25 mg.L-1) concentrations and decreased free IGF-I concentrations (-0.14 +/- 0.21 mu g.L-1). After 8 wk of training, total IGF-I concentrations were significantly increased (change in POST concentrations from week 0 to week 8 = +82.5 +/- 120.8 mu g.L-1), and IGFBP-1 concentrations were significantly decreased (-6.7 +/- 13.6 mu g.L-1) during exercise in groups that participated in resistance training (R and R + E); no significant changes were seen after E or C. Conclusions: Participation in resistance training increased total IGF-I and reduced IGFBP-1 concentrations during acute RE, indicating exercise mode-specific adaptations in the circulating IGF-I system.
C1 [Gregory, Sara M.; Spiering, Barry A.; Alemany, Joseph A.; Tuckow, Alexander P.; Rarick, Kevin R.; Staab, Jeffery S.; Nindl, Bradley C.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA.
[Gregory, Sara M.] Springfield Coll, Dept Exercise & Sports Studies, Springfield, MA USA.
[Spiering, Barry A.; Hatfield, Disa L.; Kraemer, William J.; Maresh, Carl M.] Univ Connecticut, Dept Kinesiol, Storrs, CT USA.
[Alemany, Joseph A.] Univ S Carolina, Dept Exercise Sci, Columbia, SC 29208 USA.
[Hatfield, Disa L.] Univ Rhode Isl, Dept Kinesiol, Kingston, RI 02881 USA.
RP Nindl, BC (reprint author), USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA.
EM Bradley.nindl@us.army.mil
FU U.S. Army Medical Research and Materiel Command Bone Health and Military
Medical Readiness Research Program
FX This research was supported by a grant from the U.S. Army Medical
Research and Materiel Command Bone Health and Military Medical Readiness
Research Program to BCN.
NR 40
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U1 0
U2 19
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAR
PY 2013
VL 45
IS 3
BP 420
EP 428
DI 10.1249/MSS.0b013e3182750bd4
PG 9
WC Sport Sciences
SC Sport Sciences
GA 094MT
UT WOS:000315268700004
PM 23034644
ER
PT J
AU Hakre, S
Arteaga, G
Nunez, AE
Bautista, CT
Bolen, A
Villarroel, M
Peel, SA
Paz-Bailey, G
Scott, PT
Pascale, JM
AF Hakre, Shilpa
Arteaga, Griselda
Nunez, Aurelio E.
Bautista, Christian T.
Bolen, Aimee
Villarroel, Maria
Peel, Sheila A.
Paz-Bailey, Gabriela
Scott, Paul T.
Pascale, Juan M.
CA Panama HIV EPI Grp
TI Prevalence of HIV and other sexually transmitted infections and factors
associated with syphilis among female sex workers in Panama
SO SEXUALLY TRANSMITTED INFECTIONS
LA English
DT Article
ID SURVEILLANCE; POPULATIONS; PREVENTION; VIOLENCE; CLIENTS; MEXICO
AB Objectives Biological and behavioural surveillance of HIV and sexually transmitted infections (STIs) among populations at highest risk have been used to monitor trends in prevalence and in risk behaviours. Sex work in Panama is regulated through registration with the Social Hygiene Programme, Ministry of Health. We estimated prevalence of HIV and STIs, and factors associated with active syphilis among female sex workers (FSWs).
Methods A cross-sectional study using venue-based, time-space sampling was conducted among FSWs in Panama from 2009 to 2010. FSWs were interviewed about sociodemographic characteristics, sexual risk behaviour, health history and drug use using an anonymous structured questionnaire. Blood was collected for serological testing of HIV and other STIs. Factors associated with active syphilis were studied using logistic regression analysis.
Results The overall HIV-1 prevalence of 0.7% varied by FSW category; 1.6% in 379 unregistered, and 0.2% in 620 registered FSWs. Overall prevalence (and 95% CI) of STIs were: syphilis antibody, 3.8% (2.7% to 5.2%); herpes simplex virus type 2 antibody (anti-HSV-2), 74.2% (71.4% to 76.9%); hepatitis B surface antigen, 0.6% (0.2% to 1.3%); hepatitis B core antibody, 8.7% (7.0% to 10.6%); and hepatitis C antibody, 0.2% (0.0% to 0.7%). In multivariate analysis, registration (adjusted OR (AOR) =0.35; 95% CI 0.16 to 0.74), having a history of STI (AOR=2.37; 95% CI 1.01 to 5.58), forced sex (AOR=2.47; 95% CI 1.11 to 5.48), and anti-HSV-2 (AOR=10.05; 95% CI 1.36 to 74.38) were associated with active syphilis.
Conclusions Although HIV prevalence is low among FSWs in Panama, unregistered FSWs bear a higher burden of HIV and STIs than registered FSWs. Programmes aimed at overcoming obstacles to registration, and HIV, STI and harm reduction among unregistered FSWs is warranted to prevent HIV transmission, and to improve their sexual and reproductive health.
C1 [Hakre, Shilpa; Bolen, Aimee; Villarroel, Maria] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Dept Epidemiol & Threat Assessment, Bethesda, MD USA.
[Arteaga, Griselda; Pascale, Juan M.] Inst Conmemorat Gorgas Estudios Salud, Panama City, Panama.
[Nunez, Aurelio E.] Minist Hlth, Natl HIV AIDS Control Program, Panama City, Panama.
[Bautista, Christian T.] Walter Reed Army Inst Res, Dept Prevent Med, Silver Spring, MD USA.
[Peel, Sheila A.; Scott, Paul T.] Walter Reed Army Inst Res, US Mil HIV Res Program, Rockville, MD USA.
[Paz-Bailey, Gabriela] Del Valle Univ Guatemala, Ctr Estudios Salud, Guatemala City, Guatemala.
RP Hakre, S (reprint author), US Mil HIV Res Program, Dept Epidemiol & Threat Assessment, 6720-A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA.
EM shakre@hivresearch.org
FU Military Infectious Disease Research Program; Republic of Panama; Pan
American Health Organization; Global Funds; Centers for Disease Control
and Prevention; Panama National Program of HIV
FX This work was supported by funds from the Military Infectious Disease
Research Program, Secretary of Science and Technology of the Republic of
Panama, Pan American Health Organization, Global Funds, Centers for
Disease Control and Prevention, Panama National Program of HIV.
NR 22
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U1 1
U2 6
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1368-4973
J9 SEX TRANSM INFECT
JI Sex. Transm. Infect.
PD MAR
PY 2013
VL 89
IS 2
BP 156
EP 164
DI 10.1136/sextrans-2012-050557
PG 9
WC Infectious Diseases
SC Infectious Diseases
GA 093QZ
UT WOS:000315207800021
PM 23002191
ER
PT J
AU Rosado, JI
Johnson, SB
McGinnity, KA
Cuevas, JP
AF Rosado, Javier I.
Johnson, Suzanne Bennett
McGinnity, Kelly A.
Cuevas, Jordan P.
TI Obesity Among Latino Children Within a Migrant Farmworker Community
SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE
LA English
DT Article
ID BODY-MASS INDEX; US CHILDREN; MOTHERS PERCEPTIONS; PHYSICAL-ACTIVITY;
SCHOOL-CHILDREN; YOUNG-CHILDREN; PRIMARY-CARE; ADOLESCENTS; PREVALENCE;
OVERWEIGHT
AB Background: Childhood obesity has increased substantially among Latino children, placing them at risk for its related health consequences. Limited attention has been given to childhood obesity among Latino migrant farm-working communities.
Purpose: To examine, within a migrant farm-working community, (1) the prevalence of obesity among Latino children and parents and (2) parent perceptions of children's weight status and intentions to take corrective action.
Methods: Structured interviews were completed with the parents of 495 children seen for well-child office visits in the pediatric department of a community health center during a 15-month period between 2010 and 2011. Medical chart reviews were completed for each child participant.
Results: Forty-seven percent of the children were overweight (20%) or obese (27%). In comparison to preschool-aged children, those in elementary and middle school were more likely to be obese. In elementary school, girls were more likely than boys to be overweight or obese. Child obesity was associated with parent obesity. Parental concern about their child's weight was associated with child obesity but not with child overweight. Parental concern was associated with parent intention to address the child's weight, particularly in older children. Analysis was completed in 2012.
Conclusions: Interventions are needed that address both childhood obesity and parent weight status among Latino migrant farmworkers. Prevention programs that address the weight status of Latino children who are overweight, but not necessarily obese, are also needed, as their parents tend to be no more concerned about a child who is overweight than one who is normal weight. (Am J Prev Med 2013;44(3S3):S274-S281) (c) 2013 American Journal of Preventive Medicine
C1 [Johnson, Suzanne Bennett] Florida State Univ, Coll Med, Tallahassee, FL 32306 USA.
[McGinnity, Kelly A.] Florida State Univ, Dept Stat, Tallahassee, FL 32306 USA.
[Cuevas, Jordan P.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA.
RP Rosado, JI (reprint author), 1441 Heritage Blvd, Immokalee, FL 34142 USA.
EM javier.rosado@med.fsu.edu
FU Robert Wood Johnson Foundation; Robert Wood Johnson Foundation through
its national program, Salud America! The RWJF Research Network to
Prevent Obesity Among Latino Children
FX Publication of this article was supported by the Robert Wood Johnson
Foundation.; This study was funded by the Robert Wood Johnson Foundation
through its national program, Salud America! The RWJF Research Network
to Prevent Obesity Among Latino Children (www.salud-america.org). Salud
America!, led by the Institute for Health Promotion Research at The
University of Texas Health Science Center at San Antonio, Texas, unites
Latino researchers and advocates seeking environmental and policy
solutions to the epidemic.
NR 37
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U1 0
U2 13
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0749-3797
J9 AM J PREV MED
JI Am. J. Prev. Med.
PD MAR
PY 2013
VL 44
IS 3
SU 3
BP S274
EP S281
DI 10.1016/j.amepre.2012.11.019
PG 8
WC Public, Environmental & Occupational Health; Medicine, General &
Internal
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 090FD
UT WOS:000314963700015
PM 23415193
ER
PT J
AU Dai, TH
Gupta, A
Huang, YY
Yin, R
Murray, CK
Vrahas, MS
Sherwood, ME
Tegos, GP
Hamblin, MR
AF Dai, Tianhong
Gupta, Asheesh
Huang, Ying-Ying
Yin, Rui
Murray, Clinton K.
Vrahas, Mark S.
Sherwood, Margaret E.
Tegos, George P.
Hamblin, Michael R.
TI Blue Light Rescues Mice from Potentially Fatal Pseudomonas aeruginosa
Burn Infection: Efficacy, Safety, and Mechanism of Action
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID ANTIMICROBIAL PHOTODYNAMIC THERAPY; MRSA IN-VITRO; WOUND INFECTIONS;
HELICOBACTER-PYLORI; ULTRAVIOLET-LIGHT; VISIBLE-LIGHT; INACTIVATION;
BACTERIA; MODEL; RESISTANCE
AB Blue light has attracted increasing attention due to its intrinsic antimicrobial effect without the addition of exogenous photosensitizers. However, the use of blue light for wound infections has not been established yet. In this study, we demonstrated the efficacy of blue light at 415 nm for the treatment of acute, potentially lethal Pseudomonas aeruginosa burn infections in mice. Our in vitro studies demonstrated that the inactivation rate of P. aeruginosa cells by blue light was approximately 35-fold higher than that of keratinocytes (P = 0.0014). Transmission electron microscopy revealed blue light-mediated intracellular damage to P. aeruginosa cells. Fluorescence spectroscopy suggested that coproporphyrin III and/or uroporphyrin III are possibly the intracellular photosensitive chromophores associated with the blue light inactivation of P. aeruginosa. In vivo studies using an in vivo bioluminescence imaging technique and an area-under-the-bioluminescence-time-curve (AUBC) analysis showed that a single exposure of blue light at 55.8 J/cm(2), applied 30 min after bacterial inoculation to the infected mouse burns, reduced the AUBC by approximately 100-fold in comparison with untreated and infected mouse burns (P < 0.0001). Histological analyses and terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling (TUNEL) assays indicated no significant damage in the mouse skin exposed to blue light at the effective antimicrobial dose. Survival analyses revealed that blue light increased the survival rate of the infected mice from 18.2% to 100% (P < 0.0001). In conclusion, blue light therapy might offer an effective and safe alternative to conventional antimicrobial therapy for P. aeruginosa burn infections.
C1 [Dai, Tianhong; Gupta, Asheesh; Huang, Ying-Ying; Yin, Rui; Sherwood, Margaret E.; Tegos, George P.; Hamblin, Michael R.] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA.
[Dai, Tianhong; Gupta, Asheesh; Huang, Ying-Ying; Yin, Rui; Tegos, George P.; Hamblin, Michael R.] Harvard Univ, Sch Med, Dept Dermatol, Boston, MA 02115 USA.
[Gupta, Asheesh] Def Inst Physiol & Allied Sci, Delhi, India.
[Huang, Ying-Ying] Guangxi Med Univ, Dept Pathol, Nanning, Guangxi, Peoples R China.
[Gupta, Asheesh] Third Mil Med Univ, Southwest Hosp, Dept Dermatol, Chongqing, Peoples R China.
[Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA.
[Vrahas, Mark S.] Massachusetts Gen Hosp, Dept Orthopaed Surg, Boston, MA 02114 USA.
[Tegos, George P.] Univ New Mexico, Sch Med, Dept Pathol, Albuquerque, NM 87131 USA.
[Hamblin, Michael R.] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA.
RP Hamblin, MR (reprint author), Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA.
EM hamblin@helix.mgh.harvard.edu
RI Huang, Ying-ying/G-3153-2011;
OI Huang, Ying-ying/0000-0003-3066-6981; Hamblin,
Michael/0000-0001-6431-4605
FU Airlift Research Foundation [109421]; COTA/Smith Nephew grant [2012-16];
CIMIT Innovation grant [13-1033]; NIH [RO1AI050875]
FX This study was supported in part by Airlift Research Foundation
Extremity Trauma Research grant 109421 (to T. D.), COTA/Smith & Nephew
grant 2012-16 (to T. D.), CIMIT Innovation grant 13-1033 (to T. D.), and
NIH grant RO1AI050875 (to M. R. H.). The funders had no role in the
study design, data collection and analysis, decision to publish, or
preparation of the manuscript.
NR 50
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PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD MAR
PY 2013
VL 57
IS 3
BP 1238
EP 1245
DI 10.1128/AAC.01652-12
PG 8
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA 090GU
UT WOS:000314968100018
PM 23262998
ER
PT J
AU Gunosewoyo, H
Tipparaju, SK
Pieroni, M
Wang, Y
Doctor, BP
Nambiar, MP
Kozikowski, AP
AF Gunosewoyo, Hendra
Tipparaju, Suresh K.
Pieroni, Marco
Wang, Ying
Doctor, Bhupendra P.
Nambiar, Madhusoodana P.
Kozikowski, Alan P.
TI Structural analogs of huperzine A improve survival in guinea pigs
exposed to soman
SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
LA English
DT Article
DE Huperzine A analogs; Neuroprotection; Nerve agent; Soman;
Acetylcholinesterase
ID NOOTROPIC AGENT HUPERZINE; INDUCED OXIDATIVE INJURY; RAT
CORTICAL-NEURONS; ANTICHOLINESTERASE ACTIVITY; INDUCED SEIZURES; NERVE
AGENTS; TOXICITY; EFFICACY; CHOLINESTERASES; PRETREATMENTS
AB Chemical warfare nerve agents such as soman exert their toxic effects through an irreversible inhibition of acetylcholinesterase (AChE) and subsequently glutamatergic function, leading to uncontrolled seizures. The natural alkaloid (-)-huperzine A is a potent inhibitor of AChE and has been demonstrated to exert neuroprotection at an appropriate dose. It is hypothesized that analogs of both (+)- and (-)-huperzine A with an improved ability to interact with NMDA receptors together with reduced AChE inhibition will exhibit more effective neuroprotection against nerve agents. In this manuscript, the tested huperzine A analogs 2 and 3 were demonstrated to improve survival of guinea pigs exposed to soman at either 1.2 or 2 x LD50. (c) 2012 Elsevier Ltd. All rights reserved.
C1 [Gunosewoyo, Hendra; Tipparaju, Suresh K.; Pieroni, Marco; Kozikowski, Alan P.] Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA.
[Wang, Ying; Doctor, Bhupendra P.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA.
RP Kozikowski, AP (reprint author), Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, 833 S Wood St, Chicago, IL 60612 USA.
EM kozikowa@uic.edu
OI Gunosewoyo, Hendra/0000-0003-3897-1948; Pieroni,
Marco/0000-0001-9190-3712
FU US Army Medical Research and Material Command [W81XWH-08-1-0201]
FX This work was supported by the US Army Medical Research and Material
Command (Contract number W81XWH-08-1-0201). H.G. would like to thank Dr.
Werner Tuckmantel for his critical proofreading of the manuscript.
NR 32
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U1 2
U2 23
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0960-894X
J9 BIOORG MED CHEM LETT
JI Bioorg. Med. Chem. Lett.
PD MAR 1
PY 2013
VL 23
IS 5
BP 1544
EP 1547
DI 10.1016/j.bmcl.2012.11.083
PG 4
WC Chemistry, Medicinal; Chemistry, Organic
SC Pharmacology & Pharmacy; Chemistry
GA 086NZ
UT WOS:000314693400077
PM 23395652
ER
PT J
AU Hogan, M
Bahta, M
Cherry, S
Lountos, GT
Tropea, JE
Zhao, BM
Burke, TR
Waugh, DS
Ulrich, RG
AF Hogan, Megan
Bahta, Medhanit
Cherry, Scott
Lountos, George T.
Tropea, Joseph E.
Zhao, Bryan M.
Burke, Terrence R., Jr.
Waugh, David S.
Ulrich, Robert G.
TI Biomolecular Interactions of Small-molecule Inhibitors Affecting the
YopH Protein Tyrosine Phosphatase
SO CHEMICAL BIOLOGY & DRUG DESIGN
LA English
DT Article
DE affinity screening; competitive binding assay; high-throughput
screening; peptide microarray; phosphopeptide; protein tyrosine
phosphatase; surface plasmon resonance; Yersinia pestis outer protein H
ID SUBSTRATE-TRAPPING MUTANTS; YERSINIA-PESTIS; SH2 DOMAINS; BINDING;
LIBRARY; DEPHOSPHORYLATION; IDENTIFICATION; SPECIFICITY; MECHANISM;
DISCOVERY
AB We have developed competitive and direct binding methods to examine small-molecule inhibitors of protein tyrosine phosphatase activity. Focusing on the Yersinia pestis outer protein H, a potent bacterial protein tyrosine phosphatase, we describe how an understanding of the kinetic interactions involving Yersinia pestis outer protein H, peptide substrates, and small-molecule inhibitors of protein tyrosine phosphatase activity can be beneficial for inhibitor screening, and we further translate these results into a microarray assay for high-throughput screening.
C1 [Hogan, Megan; Zhao, Bryan M.; Ulrich, Robert G.] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
[Bahta, Medhanit; Burke, Terrence R., Jr.] NCI, Biol Chem Lab, Ctr Canc Res, NIH,Frederick Natl Lab Canc Res, Ft Detrick, MD 21702 USA.
[Cherry, Scott; Lountos, George T.; Tropea, Joseph E.; Waugh, David S.] NCI, Macromol Crystallog Lab, Ctr Canc Res, NIH,Frederick Natl Lab, Ft Detrick, MD 21702 USA.
[Lountos, George T.] SAIC Frederick Inc, Frederick Natl Lab, Basic Sci Program, Frederick, MD 21702 USA.
RP Ulrich, RG (reprint author), USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
EM rulrich@bhsai.org
RI Burke, Terrence/N-2601-2014; Lountos, George/B-3983-2015
FU Department of Defense; Joint Science and Technology Office; Frederick
National Laboratory for Cancer Research; National Institutes of Health
[HHSN261200800001E]; Intramural Research Program of the NIH; National
Cancer Institute; Center for Cancer Research
FX This project was supported in part by an appointment of MH to the
Research Participation Program for the U.S. Army Medical Research and
Materiel Command, administered by the Oak Ridge Institute for Science
and Education through an agreement between the U.S. Department of Energy
and the USAMRMC and by funding from: the Department of Defense, Joint
Science and Technology Office; federal funds from the Frederick National
Laboratory for Cancer Research, National Institutes of Health, under
contract HHSN261200800001E; and the Intramural Research Program of the
NIH, National Cancer Institute, Center for Cancer Research. The content
of this publication does not necessarily reflect the views or policies
of the Department of Health and Human Services, nor does the mention of
trade names, commercial products or organizations imply endorsement by
the U.S. Government.
NR 31
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U1 0
U2 9
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1747-0277
J9 CHEM BIOL DRUG DES
JI Chem. Biol. Drug Des.
PD MAR
PY 2013
VL 81
IS 3
BP 323
EP 333
DI 10.1111/cbdd.12097
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Medicinal
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 090NM
UT WOS:000314985900002
PM 23241354
ER
PT J
AU Funari, T
AF Funari, T.
TI A Clinical Nurse Specialist's Role in Developing Strategies to
Facilitate Early Transfer of Cardiothoracic Patients to the Intermediate
Care Unit
SO CLINICAL NURSE SPECIALIST
LA English
DT Meeting Abstract
C1 [Funari, T.] Brooke Army Med Ctr, St Hedwig, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0887-6274
J9 CLIN NURSE SPEC
JI Clin. Nurse Spec.
PD MAR-APR
PY 2013
VL 27
IS 2
BP E9
EP E10
PG 2
WC Nursing
SC Nursing
GA 088YK
UT WOS:000314873600023
ER
PT J
AU Mittelsteadt, PB
Hayes, E
Mann-Salinas, E
Phillips, S
Robbins, J
Serio-Melvin, ML
Shingleton, SK
Tubera, D
AF Mittelsteadt, P. B.
Hayes, E.
Mann-Salinas, E.
Phillips, S.
Robbins, J.
Serio-Melvin, M. L.
Shingleton, S. K.
Tubera, D.
TI SESSION C5: PILLARS OF CARE WITHIN A REGIONAL MILITARY BURN CENTER
SO CLINICAL NURSE SPECIALIST
LA English
DT Meeting Abstract
C1 [Mittelsteadt, P. B.; Hayes, E.; Mann-Salinas, E.; Phillips, S.; Robbins, J.; Serio-Melvin, M. L.; Shingleton, S. K.; Tubera, D.] USA, Inst Surg Res, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0887-6274
J9 CLIN NURSE SPEC
JI Clin. Nurse Spec.
PD MAR-APR
PY 2013
VL 27
IS 2
BP E64
EP E64
PG 1
WC Nursing
SC Nursing
GA 088YK
UT WOS:000314873600165
ER
PT J
AU Mittelsteadt, PB
Marchok, D
Vanek, A
AF Mittelsteadt, P. B.
Marchok, D.
Vanek, A.
TI Individual Perceptions of Collective Teamwork Among Army Forward
Surgical Teams
SO CLINICAL NURSE SPECIALIST
LA English
DT Meeting Abstract
C1 [Mittelsteadt, P. B.] USA, Inst Surg Res, San Antonio, TX USA.
[Marchok, D.] USA, Heidelberg APO, AE USA.
[Vanek, A.] USA, Honolulu, HI USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0887-6274
J9 CLIN NURSE SPEC
JI Clin. Nurse Spec.
PD MAR-APR
PY 2013
VL 27
IS 2
BP E35
EP E35
PG 1
WC Nursing
SC Nursing
GA 088YK
UT WOS:000314873600089
ER
PT J
AU Phillips, S
Mann-Salinas, E
Mittelsteadt, P
Robbins, J
Serio-Melvin, ML
Shingleton, SK
Tubera, D
AF Phillips, S.
Mann-Salinas, E.
Mittelsteadt, P.
Robbins, J.
Serio-Melvin, M. L.
Shingleton, S. K.
Tubera, D.
TI Education Pillar: Teach, Coach, Mentor, Communicate, Coordinate
SO CLINICAL NURSE SPECIALIST
LA English
DT Meeting Abstract
C1 [Phillips, S.] USA, Inst Surg Res, San Antonio, TX USA.
[Mann-Salinas, E.; Mittelsteadt, P.; Robbins, J.; Serio-Melvin, M. L.; Shingleton, S. K.; Tubera, D.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0887-6274
J9 CLIN NURSE SPEC
JI Clin. Nurse Spec.
PD MAR-APR
PY 2013
VL 27
IS 2
BP E64
EP E65
PG 2
WC Nursing
SC Nursing
GA 088YK
UT WOS:000314873600167
ER
PT J
AU Robbins, J
Mann-Salinas, E
Mittelsteadt, P
Phillips, S
Serio-Melvin, ML
Shingleton, SK
Tubera, D
AF Robbins, J.
Mann-Salinas, E.
Mittelsteadt, P.
Phillips, S.
Serio-Melvin, M. L.
Shingleton, S. K.
Tubera, D.
TI Expert Practitioner as Change Agent: Translating and Implementing
Evidence Into Practice
SO CLINICAL NURSE SPECIALIST
LA English
DT Meeting Abstract
C1 [Robbins, J.] USA, Inst Surg Res, San Antonio, TX USA.
[Mann-Salinas, E.; Mittelsteadt, P.; Phillips, S.; Serio-Melvin, M. L.; Shingleton, S. K.; Tubera, D.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 1
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0887-6274
J9 CLIN NURSE SPEC
JI Clin. Nurse Spec.
PD MAR-APR
PY 2013
VL 27
IS 2
BP E64
EP E64
PG 1
WC Nursing
SC Nursing
GA 088YK
UT WOS:000314873600166
ER
PT J
AU Robbins, JR
Allen, DA
Mann-Salinas, E
Serio-Melvin, ML
AF Robbins, J. R.
Allen, D. A.
Mann-Salinas, E.
Serio-Melvin, M. L.
TI A Comparison of 3 Burn Resuscitation Formulas: The Clinical Nurse
Specialist Role
SO CLINICAL NURSE SPECIALIST
LA English
DT Meeting Abstract
C1 [Robbins, J. R.; Allen, D. A.] USA, Inst Surg Res, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0887-6274
J9 CLIN NURSE SPEC
JI Clin. Nurse Spec.
PD MAR-APR
PY 2013
VL 27
IS 2
BP E14
EP E15
PG 2
WC Nursing
SC Nursing
GA 088YK
UT WOS:000314873600037
ER
PT J
AU Rose, T
AF Rose, T.
TI Track and Trigger: Implementing an Early Warning Scoring System in the
Intermediate Care Unit
SO CLINICAL NURSE SPECIALIST
LA English
DT Meeting Abstract
C1 [Rose, T.] USA, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0887-6274
J9 CLIN NURSE SPEC
JI Clin. Nurse Spec.
PD MAR-APR
PY 2013
VL 27
IS 2
BP E51
EP E52
PG 2
WC Nursing
SC Nursing
GA 088YK
UT WOS:000314873600132
ER
PT J
AU Shingleton, S
Mann-Salinas, E
Phillips, S
Robbins, J
Seriomelvin, ML
Tubera, D
AF Shingleton, S.
Mann-Salinas, E.
Phillips, S.
Robbins, J.
Seriomelvin, M. L.
Tubera, D.
TI Wounds, Wounds, Wounds: The Clinical Nurse Specialist's Role in a Burn
Center
SO CLINICAL NURSE SPECIALIST
LA English
DT Meeting Abstract
C1 [Shingleton, S.] USA, Inst Surg Res, San Antonio, TX USA.
[Mann-Salinas, E.; Phillips, S.; Robbins, J.; Seriomelvin, M. L.; Tubera, D.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0887-6274
J9 CLIN NURSE SPEC
JI Clin. Nurse Spec.
PD MAR-APR
PY 2013
VL 27
IS 2
BP E65
EP E65
PG 1
WC Nursing
SC Nursing
GA 088YK
UT WOS:000314873600168
ER
PT J
AU Tubera, D
Savell, K
AF Tubera, D.
Savell, K.
TI Burn Care Program: Building Clinical Competency for Air Force Critical
Care/Emergency Nursing Fellows
SO CLINICAL NURSE SPECIALIST
LA English
DT Meeting Abstract
C1 [Tubera, D.] USA, Inst Surg Res, San Antonio, TX USA.
[Savell, K.] USAF, Lackland AFB, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0887-6274
J9 CLIN NURSE SPEC
JI Clin. Nurse Spec.
PD MAR-APR
PY 2013
VL 27
IS 2
BP E5
EP E6
PG 2
WC Nursing
SC Nursing
GA 088YK
UT WOS:000314873600014
ER
PT J
AU Quinn, MJ
Hanna, TL
Shiflett, AA
McFarland, CA
Cook, ME
Johnson, MS
Gust, KA
Perkins, EJ
AF Quinn, Michael J.
Hanna, Terry L.
Shiflett, Alicia A.
McFarland, Craig A.
Cook, Michelle E.
Johnson, Mark S.
Gust, Kurt A.
Perkins, Edward J.
TI Interspecific effects of 4A-DNT (4-amino-2,6-dinitrotoluene) and RDX
(1,3,5-trinitro-1,3,5-triazine) in Japanese quail, Northern bobwhite,
and Zebra finch
SO ECOTOXICOLOGY
LA English
DT Article
DE Interspecies; Munitions; Explosive; Avian; Ecotoxicology
ID COLINUS-VIRGINIANUS; EXPOSURE; GENOMICS; SONGBIRD; BRAIN
AB The purpose of this study was to assess the toxicological effects of two munition compounds, 4-amino-2,6-dinitrotoluene (4A-DNT) and 1,3,5-trinitro-1,3,5-triazine (RDX), on three different bird species: two common toxicological model species-the Northern Bobwhite (Colinus virginianus) and the Japanese Quail (Coturnix japonica), and a representative passerine-the Zebra Finch (Taeniopygia guttata). Bobwhite were exposed to 4A-DNT at 0, 8, 15, 30, 60, or 150 mg/kg body weight (bw) d by oral gavage for seven days; because the high dose of 4A-DNT was lethal to bobwhite, the maximum dose was changed to 100 mg/kg bw d for Japanese quail and finches to ensure tissue could be used for future toxicogenomic work. RDX was similarly administered at 0, 0.5, 1.5, 3, 6, or 12 mg/kg bw d. Blood was drawn prior to euthanasia for blood cellularity and chemistry analyses. Finches were clearly least affected by 4A-DNT as evidenced by a lack of observable effects. Bobwhite appeared to be the most sensitive species to 4A-DNT as observed through changes in blood cellularity and plasma chemistry effects. Bobwhite appeared to be more sensitive to RDX than Japanese Quail due to increased effects on measures of plasma chemistries. Finches exhibited the greatest sensitivity to RDX through increased mortality and seizure activity. This study suggests that sensitivity among species is chemical-specific and provides data that could be used to refine current avian sensitivity models used in ecological risk assessments.
C1 [Quinn, Michael J.; Hanna, Terry L.; Shiflett, Alicia A.; McFarland, Craig A.; Johnson, Mark S.] USA, Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA.
[Cook, Michelle E.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37830 USA.
[Gust, Kurt A.; Perkins, Edward J.] US Army Corps Engineers, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Quinn, MJ (reprint author), USA, Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA.
EM michael.james.quinn@us.army.mil
FU US Army 6.2 Research Program, Focus Area: Impact of Munitions
Constituents on Biological Networks
FX This study was funded by US Army 6.2 Research Program, Focus Area:
Impact of Munitions Constituents on Biological Networks
NR 33
TC 2
Z9 2
U1 0
U2 23
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0963-9292
J9 ECOTOXICOLOGY
JI Ecotoxicology
PD MAR
PY 2013
VL 22
IS 2
BP 231
EP 239
DI 10.1007/s10646-012-1019-8
PG 9
WC Ecology; Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 089GF
UT WOS:000314898100003
PM 23161369
ER
PT J
AU O'Brien, C
Cadarette, BS
AF O'Brien, Catherine
Cadarette, Bruce S.
TI Quantification of head sweating during rest and exercise in the heat
SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE Evaporation; Heat loss; Helmet
ID INDUSTRIAL SAFETY HELMETS; REGIONAL DIFFERENCES; HUMID HEAT; BODY;
TEMPERATURE; SECRETION; HYPERTHERMIA; ACCLIMATION; EVAPORATION;
RESPONSES
AB The head's capacity for evaporative heat loss is important for design of protective helmets for use in hot environments. This study quantified head sweating rate (m (sw)) in eight males during rest and exercise at three metabolic rates (338 +/- A 36, 481 +/- A 24, 622 +/- A 28 W) in hot-dry (HD: 45 A degrees C, 21 % RH) and hot-wet (HW: 35 A degrees C, 69 % RH) conditions (matched at 31.6 A degrees C WBGT), which were counterbalanced. Heads were shaved, and surface area was (458 +/- A 61 cm(2)) measured by 3D scanner. For measurement of head m (sw), dry air was passed through a sealed helmet, whereas for forearm m (sw) a capsule (15.9 cm(2)) was ventilated with ambient air. Evaporation rate was determined from the increase in vapor pressure in the exiting air. Whole-body sweat loss was calculated from the change in nude weight plus fluid intake and corrected for respiratory fluid losses. Head m (sw) increased (p = 0.001) with metabolic rate, and was lower (p = 0.018) in HD (0.4 +/- A 0.2 mg cm(-2) min(-1) at rest to 1.1 +/- A 0.6 mg cm(-2) min(-1) at 622 W), compared to HW (0.5 +/- A 0.3-1.4 +/- A 0.8 mg cm(-2) min(-1)). Forearm m (sw) increased (p < 0.001) with metabolic rate, but was higher (p = 0.002) in HD (0.4 +/- A 0.3-1.4 +/- A 0.7 mg cm(-2) min(-1)) than HW (0.1 +/- A 0.1-1.1 +/- A 0.3 mg cm(-2) min(-1)). Whole-body sweat loss was not significantly different (p = 0.06) between HD (647 +/- A 139 g m(-2) h(-1)) and HW (528 +/- A 189 g m(-2) h(-1)). This study demonstrates the importance of the head for evaporative heat loss, particularly for populations who wear protective clothing which can impair vapor transfer from the skin.
C1 [O'Brien, Catherine; Cadarette, Bruce S.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA.
RP O'Brien, C (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA.
EM kate.obrien@us.army.mil
NR 36
TC 2
Z9 2
U1 0
U2 13
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1439-6319
J9 EUR J APPL PHYSIOL
JI Eur. J. Appl. Physiol.
PD MAR
PY 2013
VL 113
IS 3
BP 735
EP 741
DI 10.1007/s00421-012-2482-x
PG 7
WC Physiology; Sport Sciences
SC Physiology; Sport Sciences
GA 087PF
UT WOS:000314773500020
PM 22941031
ER
PT J
AU Harrison, SA
Abdurakhmanov, D
Shiffman, ML
Bakulin, I
Mazur, W
Rodriguez-Torres, M
Silva, GF
Cheinquer, H
Messinger, D
Connell, EV
McKenna, M
Tatsch, F
Reddy, KR
AF Harrison, Stephen A.
Abdurakhmanov, Djamal
Shiffman, Mitchell L.
Bakulin, Igor
Mazur, Wlodzimierz
Rodriguez-Torres, Maribel
Silva, Giovanni Faria
Cheinquer, Hugo
Messinger, Diethelm
Connell, Edward V.
McKenna, Michael
Tatsch, Fernando
Reddy, K. Rajender
CA PROGRESS Investigators
TI Intensified Peginterferon alpha-2a Dosing Increases Sustained Virologic
Response Rates in Heavy, High Viral Load Hepatitis C Genotype 1 Patients
With High Low-density Lipoprotein
SO JOURNAL OF CLINICAL GASTROENTEROLOGY
LA English
DT Article
DE chronic hepatitis C; low-density lipoprotein; pegylated interferon;
ribavirin; sustained virologic response
ID VIRUS-INFECTION; PLUS RIBAVIRIN; CHOLESTEROL LEVELS; SERUM-CHOLESTEROL;
VERY-LOW; THERAPY; TELAPREVIR; STEATOSIS; RECEPTOR; TRIAL
AB Background and Goal: Patients infected with hepatitis C virus (HCV) with elevated low-density lipoprotein (LDL) levels achieve higher sustained virologic response (SVR) rates after peginterferon (PegIFN)/ribavirin treatment versus patients with lower LDL. Our aim was to determine whether SVR rates in patients with low/elevated LDL can be improved by dose intensification.
Study: In PROGRESS, genotype 1 patients with baseline HCV RNA >= 400,000 IU/mL and body weight >= 85 kg were randomized to 48 weeks of 180 mu g/wk PegIFN alpha-2a (40 kDa) plus ribavirin (A: 1200 mg/d; B: 1400/1600 mg/d) or 12 weeks of 360 mu g/wk PegIFN alpha-2a followed by 36 weeks of 180 mu g/wk, plus ribavirin (C: 1200 mg/d; D: 1400/1600 mg/d). This retrospective analysis assessed SVR rates among patients with low (< 100 mg/dL) or elevated (>= 100 mg/dL) LDL. Patients with high LDL (n = 256) had higher baseline HCV RNA (5.86 x 10(6) IU/mL) versus patients with low LDL (n = 262; 4.02 x 10(6) IU/mL; P = 0.0003).
Results: Multiple logistic regression analysis identified a significant interaction between PegIFN alpha-2a dose and LDL levels on SVR (P = 0.0193). The only treatment-related SVR predictor in the nested multiple logistic regression was PegIFN alpha-2a dose among patients with elevated LDL (P = 0.0074); therefore, data from the standard (A + B) and induction (C + D) dose arms were pooled. Among patients with low LDL, SVR rates were 40% and 35% in the standard and induction-dose groups, respectively; SVR rates in patients with high LDL were 44% and 60% (P = 0.014), respectively.
Conclusions: Intensified dosing of PegIFN alpha-2a increases SVR rates in patients with elevated LDL even with the difficult-to-cure characteristics of genotype 1, high baseline viral load, and high body weight.
C1 [Harrison, Stephen A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
[Shiffman, Mitchell L.] Bon Secours Hlth Syst, Liver Inst Virginia, Newport News, VA USA.
[Abdurakhmanov, Djamal] Moscow Med Acad, Moscow, Russia.
[Bakulin, Igor] Minist Def Russian Federat, State Postgrad Med Inst, Moscow, Russia.
[Mazur, Wlodzimierz] Med Univ Silesia, Chorzow, Poland.
[Rodriguez-Torres, Maribel] Fdn Invest Diego Santurce, Santurce, PR USA.
[Silva, Giovanni Faria] Botucatu Sch Med, Botucatu, SP, Brazil.
[Cheinquer, Hugo] Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil.
[Messinger, Diethelm] IST GmbH, Mannheim, Germany.
[Connell, Edward V.] Roche, Nutley, NJ USA.
[McKenna, Michael] Roche, Welwyn Garden City, England.
[Tatsch, Fernando] Roche, Basel, Switzerland.
[Reddy, K. Rajender] Univ Penn, Philadelphia, PA 19104 USA.
RP Harrison, SA (reprint author), Brooke Army Med Ctr, Div Gastroenterol & Hepatol, Ft Sam Houston, TX 78234 USA.
EM stephen.a.harrison@us.army.mil
RI Bakulin, I. G./P-4453-2014
OI Bakulin, I. G./0000-0002-6151-2021
FU Roche, Basel, Switzerland; Merck; Pfizer; Genentech; Biolex; Celera
Diagnostics, LLC; Conatus Pharmaceuticals; Exalenz; Gilead Sciences
Inc.; GlaxoSmithKline; GlobeImmune Inc.; Human Genome Sciences Inc.;
Idenix Pharmaceuticals; Johnson & Johnson/Tibotec; Pharmasset Inc.;
Roche; Romark Laboratories, LC; Schering-Plough; Valeant; Vertex
Pharmaceuticals; Wyeth; ZymoGenetics; Anadys; Vertex; Hoffman La Roche;
Genetech; Glaxo Smith Kline; Novartis; Bristol-Myers Squibb; Vertex
Pharm; Idera; Pharmasset; Sanofi-Aventis; Abbott Labs; Human Genome
Sciences; Gilead; Johnson Johnson; Akros; Scynexis; Santaris; Mochida;
Boehringer Ingelheim; Inhibitex; Idenix; Siemens; Roche-Genentech;
Tibotec
FX Supported by Roche, Basel, Switzerland. Support for third-party writing
assistance for this manuscript was provided by F. Hoffmann-La Roche Ltd.
The view(s) expressed herein are those of the author(s) and do not
reflect the official policy or position of Brooke Army Medical Center,
the U.S. Army Medical Department, the U.S. Army Office of the Surgeon
General, the Department of the Army, Department of Defense, or the U.S.
Government.; S.A.H. is a consultant for Merck; has served on advisory
boards for Merck and Bristol-Myers Squibb; has served on speakers'
bureaux for Merck and Bristol-Myers Squibb; and has received research
grants/contracts from Merck, Pfizer, and Genentech. M. L. S. has served
on advisory committees or review panels for Anadys Pharmaceuticals Inc.,
Bayer, Biolex, Bristol-Myers Squibb, Celera Diagnostics, LLC, Conatus
Pharmaceuticals, Echosense, Exalenz, Gilead Sciences Inc., Human Genome
Sciences Inc., Merck & Co Inc., Schering-Plough, Pfizer Inc., Roche,
Romark Laboratories, LC, Salix Pharmaceuticals, Valeant, Vertex
Pharmaceuticals, and ZymoGenetics; has served as a consultant for Celera
Diagnostics, LLC, Conatus Pharmaceuticals, Exalenz, Human Genome
Sciences Inc., Pfizer Inc., and Roche; has received research grant
support from Biolex, Celera Diagnostics, LLC, Conatus Pharmaceuticals,
Exalenz, Gilead Sciences Inc., GlaxoSmithKline, GlobeImmune Inc., Human
Genome Sciences Inc., Idenix Pharmaceuticals, Johnson & Johnson/Tibotec,
Pharmasset Inc., Roche, Romark Laboratories, LC, Schering-Plough,
Valeant, Vertex Pharmaceuticals, Wyeth, and ZymoGenetics; has served on
the speakers' bureaux for Bayer, Bristol-Myers Squibb, Gilead Sciences
Inc., Roche, and Schering-Plough; has served on the data monitoring
board for Abbott Laboratories and Anadys Pharmaceuticals Inc.; and holds
stock options for Exalenz. I. B. is a consultant for MSD, Roche, and
Bristol-Myers Squibb; and has served on speakers' bureaux for MSD,
Roche, and Bristol-Myers Squibb. W. M. has served on advisory committees
for Bristol-Myers Squibb and has served on speakers' bureaux for Roche
and Bristol-Myers Squibb. He has obtained travel accommodations/meeting
expenses from Bristol-Myers Squibb, Roche, and Gilead. M.R.-T. has
served as a consultant for Genentech Inc./Hoffmann-La Roche Ltd., Abbott
Labs, Pharmasset, Akros, Genentech, Bristol-Myers Squibb, Novartis,
Merck, Inhibitex, Santaris and Glaxo Smith Kline; has received
grants/research support from Vertex, Anadys, Hoffman La Roche, Genetech,
Glaxo Smith Kline, Novartis, Bristol-Myers Squibb, Vertex Pharm, Idera,
Pharmasset, Sanofi-Aventis, Merck, Abbott Labs, Pfizer, Human Genome
Sciences, Gilead, Johnson & Johnson, Zymogenetics, Akros, Pfizer, Merck,
Scynexis, Santaris, Mochida, Boehringer Ingelheim, Inhibitex, Idenix,
and Siemens. G. F. S. has served on speakers' bureaux for Roche and
Merck; has received research grants/contracts from Roche and Merck; has
received travel grants from Roche and Merck. H. C. has served on
advisory boards for Roche; has served on speakers' bureaux for Roche and
Bristol-Myers Squibb; has received research grants/contracts from Roche
and Bristol-Myers Squibb; and has received travel grants from Roche. D.
M. is an employee of IST, which contracts with Roche to provide services
including statistical support. E. V. C., M. M., and F. T. are employees
of F. Hoffmann-La Roche Ltd. K. R. R. has served on advisory boards for
Roche-Genentech, Gilead, Merck, Tibotec, and Vertex; has received
research grants/contracts from Roche-Genentech, Gilead, Merck, Tibotec,
and Vertex. D. A. declares that there is nothing to disclose.
NR 43
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U1 1
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0192-0790
J9 J CLIN GASTROENTEROL
JI J. Clin. Gastroenterol.
PD MAR
PY 2013
VL 47
IS 3
BP 271
EP 279
DI 10.1097/MCG.0b013e31826102eb
PG 9
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 088UY
UT WOS:000314863800017
PM 22951527
ER
PT J
AU Jacobs, RN
Benson, JD
Stoltz, AJ
Almeida, LA
Farrell, S
Brill, G
Salmon, M
Newell, A
AF Jacobs, R. N.
Benson, J. D.
Stoltz, A. J.
Almeida, L. A.
Farrell, S.
Brill, G.
Salmon, M.
Newell, A.
TI Analysis of thermal cycle-induced dislocation reduction in
HgCdTe/CdTe/Si(211) by scanning transmission electron microscopy
SO JOURNAL OF CRYSTAL GROWTH
LA English
DT Article
DE Characterization; Defects; Molecular beam epitaxy; Semiconducting II-VI
materials; Semiconducting mercury compounds; Infrared devices
ID MOLECULAR-BEAM EPITAXY; (112)B HGCDTE/CDTE/SI; CDTE HETEROEPITAXY;
HGCDTE; SI; DENSITY
AB High threading dislocation densities limit the operability of infrared focal plane arrays based on large lattice-mismatched heterostructures such as HgCdTe/CdTe/Si. Recently it has been shown that post-growth thermal cycle annealing can routinely reduce the surface etch pit density from >5 x 10(6) cm(-2) to as low as 9 x 10(5) cm(-2). To fully exploit the procedure, a deeper understanding of the inherent dislocation dynamics is needed. In this work, we employ scanning transmission electron microscopy to analyze cross-sectional samples of HgCdTe/CdTe/Si prepared using site-specific focused ion beam milling. A key factor in this work is the use of defect decorated samples, which has allowed for a correlation of surface etch pits to dislocation segments observed in cross-section images. We have observed that the previously reported oval-shaped etch pits are likely associated with Shockley partial type dislocations, and that triangular etch pits are associated with perfect dislocations. This suggests the likelihood that interaction between mobile Shockley partial and other dislocation types are responsible in part for the observed reduction in top surface etch pit density. These studies provide a deeper understanding of dislocation reduction processes which are critical for the realization of high performance infrared detectors based on low-cost, lattice-mismatched substrates. Published by Elsevier B.V.
C1 [Jacobs, R. N.; Benson, J. D.; Stoltz, A. J.; Almeida, L. A.] USA, RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
[Farrell, S.; Brill, G.] USA, Res Lab, Ft Belvoir, VA 22060 USA.
RP Jacobs, RN (reprint author), USA, RDECOM, CERDEC Night Vis & Elect Sensors Directorate, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA.
EM info@army.nvl.mil
RI Brill, Gregory/G-4877-2013
NR 20
TC 4
Z9 4
U1 0
U2 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-0248
J9 J CRYST GROWTH
JI J. Cryst. Growth
PD MAR 1
PY 2013
VL 366
BP 88
EP 94
DI 10.1016/j.jcrysgro.2012.12.007
PG 7
WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied
SC Crystallography; Materials Science; Physics
GA 088HN
UT WOS:000314824800017
ER
PT J
AU Lever, JH
Delaney, AJ
Ray, LE
Trautmann, E
Barna, LA
Burzynski, AM
AF Lever, J. H.
Delaney, A. J.
Ray, L. E.
Trautmann, E.
Barna, L. A.
Burzynski, A. M.
TI Autonomous GPR Surveys using the Polar Rover Yeti
SO JOURNAL OF FIELD ROBOTICS
LA English
DT Article
ID COOL-ROBOT
AB The National Science Foundation operates stations on the ice sheets of Antarctica and Greenland to investigate Earth's climate history, life in extreme environments, and the evolution of the cosmos. Understandably, logistics costs predominate budgets due to the remote locations and harsh environments involved. Currently, manual ground-penetrating radar (GPR) surveys must preceed vehicle travel across polar ice sheets to detect subsurface crevasses or other voids. This exposes the crew to the risks of undetected hazards. We have developed an autonomous rover, Yeti, specifically to conduct GPR surveys across polar ice sheets. It is a simple four-wheel-drive, battery-powered vehicle that executes autonomous surveys via GPS waypoint following. We describe here three recent Yeti deployments, two in Antarctica and one in Greenland. Our key objective was to demonstrate the operational value of a rover to locate subsurface hazards. Yeti operated reliably at 30 degrees C, and it has has good oversnow mobility and adequate GPS accuracy for waypoint-following and hazard georeferencing. It has acquired data on hundreds of crevasse encounters to improve our understanding of heavily crevassed traverse routes and to develop automated crevasse-detection algorithms. Importantly, it helped to locate a previously undetected buried building at the South Pole. Yeti can improve safety by decoupling survey personnel from the consequences of undetected hazards. It also enables higher-quality systematic surveys to improve hazard-detection probabilities, increase assessment confidence, and build datasets to understand the evolution of these regions. Yeti has demonstrated that autonomous vehicles have great potential to improve the safety and efficiency of polar logistics. (c) 2012 Wiley Periodicals, Inc.
C1 [Lever, J. H.; Delaney, A. J.; Barna, L. A.; Burzynski, A. M.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
[Ray, L. E.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA.
[Trautmann, E.] Stanford Univ, Neurosci Program, Stanford, CA 94305 USA.
RP Lever, JH (reprint author), USA, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA.
EM james.lever@us.army.mil; laura.e.ray@dartmouth.edu
FU NASA's Jet Propulsion Laboratory [RSA 1310519]; NSF-OPP divisions of
Antarctic Infrastructure and Logistics and Arctic Research Support and
Logistics
FX Field deployments were sponsored by NSF-OPP divisions of Antarctic
Infrastructure and Logistics and Arctic Research Support and Logistics,
and the authors sincerely thank George Blaisdell and Pat Haggerty for
their commitments to advancing autonomous GPR surveys. These deployments
would not have been possible without the help of field personnel,
including Paul Thur and Terry Billings (SPoT), Jay Burnside, Geoff
Phillips, and Jake MacArthur (GrIT), and Martin Lewis and Andy Martinez
(Old Pole). We also thank CRREL's Steve Arcone and Zoe Courville for
advice, the loan of GPR equipment, and manual GPR support, and Doug Punt
for tireless troubleshooting and upgrades to Yeti's electronics. Funding
to build Yeti was provided by NASA's Jet Propulsion Laboratory through
RSA 1310519 and supported in part by an appointment to the Postgraduate
Research Participation Program administered by the Oak Ridge Institute
for Science and Education through an interagency agreement between the
U.S. Department of Energy and CRREL.
NR 29
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Z9 8
U1 5
U2 23
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1556-4959
J9 J FIELD ROBOT
JI J. Field Robot.
PD MAR-APR
PY 2013
VL 30
IS 2
BP 194
EP 215
DI 10.1002/rob.21445
PG 22
WC Robotics
SC Robotics
GA 087JM
UT WOS:000314757600002
ER
PT J
AU Sun, W
Eckels, KH
Putnak, JR
Lyons, AG
Thomas, SJ
Vaughn, DW
Gibbons, RV
Fernandez, S
Gunther, VJ
Mammen, MP
Statler, JD
Innis, BL
AF Sun, Wellington
Eckels, Kenneth H.
Putnak, J. Robert
Lyons, Arthur G.
Thomas, Stephen J.
Vaughn, David W.
Gibbons, Robert V.
Fernandez, Stefan
Gunther, Vicky J.
Mammen, Mammen P., Jr.
Statler, John D.
Innis, Bruce L.
TI Experimental Dengue Virus Challenge of Human Subjects Previously
Vaccinated With Live Attenuated Tetravalent Dengue Vaccines
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE dengue; tetravalent vaccine; live virus challenge
ID FLAVIVIRUS-NAIVE ADULTS; PHASE-I TRIAL; HUMAN VOLUNTEERS; CANDIDATE
VACCINES; RHESUS-MONKEYS; 4 SEROTYPES; IMMUNOGENICITY; INFECTION;
SAFETY; FORMULATIONS
AB Background. Protection against dengue requires immunity against all 4 serotypes of dengue virus (DENV). Experimental challenge may be useful in evaluating vaccine-induced immunity.
Methods. Ten subjects previously vaccinated with a live attenuated tetravalent dengue vaccine (TDV) and 4 DENV-naive control subjects were challenged by subcutaneous inoculation of either 10(3) plaque-forming units (PFU) of DENV-1 or 10(5) PFU of DENV-3. Two additional subjects who did not develop DENV-3 neutralizing antibody (NAb) from TDV were revaccinated with 104 PFU of live attenuated DENV-3 vaccine to evaluate memory response.
Results. All 5 TDV recipients were protected against DENV-1 challenge. Of the 5 TDV recipients challenged with DENV-3, 2 were protected. All DENV-3-challenge subjects who developed viremia also developed elevated liver enzyme levels, and 2 had values that were >10 times greater than normal. Of the 2 subjects revaccinated with DENV-3 vaccine, 1 showed a secondary response to DENV-2, while neither showed such response to DENV-3. All 4 control subjects developed dengue fever from challenge. Protection was associated with presence of NAb, although 1 subject was protected despite a lack of measurable NAb at the time of DENV-1 challenge.
Conclusions. Vaccination with TDV induced variable protection against subcutaneous challenge. DENV-3 experimental challenge was associated with transient but marked elevations of transaminases.
C1 [Sun, Wellington; Putnak, J. Robert; Lyons, Arthur G.; Thomas, Stephen J.; Vaughn, David W.; Gibbons, Robert V.; Fernandez, Stefan; Gunther, Vicky J.] Walter Reed Army Inst Res, Dept Virus Dis, Silver Spring, MD USA.
[Eckels, Kenneth H.] Walter Reed Army Inst Res, Pilot Bioprod Facil, Silver Spring, MD USA.
[Statler, John D.] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA.
[Innis, Bruce L.] GlaxoSmithKline, Vaccine Discovery & Dev, King Of Prussia, PA USA.
[Mammen, Mammen P., Jr.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
RP Sun, W (reprint author), CBER, Div Vaccines & Related Prod Applicat, Off Vaccine Res & Review, 1451 Rock Ville Pike,Rm 2302, Rockville, MD 20852 USA.
EM wellington.sun@fda.hhs.gov
RI Lyons, Arthur/B-8923-2011
FU US Army Medical Research and Materiel Command
FX This work was supported by the US Army Medical Research and Materiel
Command.
NR 41
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U1 0
U2 13
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD MAR 1
PY 2013
VL 207
IS 5
BP 700
EP 708
DI 10.1093/infdis/jis744
PG 9
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 089FD
UT WOS:000314894600002
PM 23225894
ER
PT J
AU Debboun, M
Strickman, D
AF Debboun, M.
Strickman, D.
TI Insect repellents and associated personal protection for a reduction in
human disease
SO MEDICAL AND VETERINARY ENTOMOLOGY
LA English
DT Review
DE Individual prevention; insecticide-treated bednet; integrated pest
management; malaria; mosquito; mosquito coil; public health; repellent;
vector-borne disease
ID DEET MOSQUITO REPELLENT; MALARIA CONTROL; AEDES-AEGYPTI; TREATED NETS;
BED NETS; PREVENTION; VECTORS; EFFICACY; TRIAL; LEISHMANIASIS
AB Personal protection measures against biting arthropods include topical insect repellents, area repellents, insecticide-treated bednets and treated clothing. The literature on the effectiveness of personal protection products against arthropods is mainly limited to studies of prevention of bites, rather than prevention of disease. Tungiasis was successfully controlled by application of topical repellents and scrub typhus was reduced through the use of treated clothing. Successful reduction of leishmaniasis was achieved through the use of topical repellents, treated bednets and treated clothing in individual studies. Malaria has been reduced by the use of insecticide-treated bednets (ITN), certain campaigns involving topical repellents, and the combination of treated bednets and topical repellents. Although area repellents such as mosquito coils are used extensively, their ability to protect humans from vector-transmitted pathogens has not been proven. Taken together, the literature indicates that personal protection measures must be used correctly to be effective. A study that showed successful control of malaria by combining treated bednets and topical repellents suggests that combinations of personal protection measures are likely to be more effective than single methods. Implementation of successful programmes based on personal protection will require a level of cooperation commonly associated with other basic societal functions, such as education and food safety.
C1 [Debboun, M.] USA, Dept Prevent Hlth Serv, Acad Hlth Sci, Med Dept Ctr, Ft Sam Houston, TX USA.
[Strickman, D.] ARS, Off Natl Programs, USDA, Beltsville, MD USA.
RP Strickman, D (reprint author), ARS, USDA, Natl Program Staff, Room 4-2112,5601 Sunnyside Ave, Beltsville, MD 20705 USA.
EM daniel.strickman@ars.usda.gov
NR 61
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U1 1
U2 51
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-283X
J9 MED VET ENTOMOL
JI Med. Vet. Entomol.
PD MAR
PY 2013
VL 27
IS 1
BP 1
EP 9
DI 10.1111/j.1365-2915.2012.01020.x
PG 9
WC Entomology; Veterinary Sciences
SC Entomology; Veterinary Sciences
GA 091EU
UT WOS:000315033000001
PM 22624654
ER
PT J
AU Jatapai, A
Sirivongrangson, P
Lokpichat, S
Chuenchitra, T
Nelson, KE
Rangsin, R
AF Jatapai, Anchalee
Sirivongrangson, Pachara
Lokpichat, Somchai
Chuenchitra, Thippawan
Nelson, Kenrad E.
Rangsin, Ram
TI Prevalence and Risk Factors for Chlamydia trachomatis Infection Among
Young Thai Men in 2008-2009
SO SEXUALLY TRANSMITTED DISEASES
LA English
DT Article
ID SEXUALLY-TRANSMITTED-DISEASES; NORTHERN THAILAND; HIV-INFECTION;
BEHAVIOR; WOMEN; EPIDEMIOLOGY; TRANSMISSION; ADOLESCENTS; CONTEXT;
ADULTS
AB Background: Asymptomatic Chlamydia trachomatis (CT) infection and other sexually transmitted infections in men potentially contribute significantly in sustaining the spread of the infection. To describe the distribution and related sexual behaviors, we conducted a cross-sectional study among young Thai men using a (1: 30) systematic sampling of all newly inducted military conscripts in Thailand.
Methods: In November 2008 and May 2009, participants' urine and serum samples were tested for CT and Neisseria gonorrhoeae, using a multiplex polymerase chain reaction technique, and serologic testing for Treponema pallidum and HIV-1 was done. Information on demographic data and risk behaviors was obtained by a self-administered questionnaire.
Results: The overall prevalence rates of CT, N. gonorrhoeae, HIV-1, and syphilis infection were 7.9%, 0.9%, 0.5%, 0.05%, respectively. The risk factors for CT infection were living in the upper north region (adjusted rate ratios [95% confidence interval], 2.13 [1.39-3.26]), having had 4 or more sexual partners (2.14 [1.48-3.09]), graduation from a vocational school (1.66 [1.14-2.41]), inconsistent condom use (1.48 [1.05-2.08]), unemployment (1.82 [1.06-3.12]), and age 21 years or younger (1.63 [1.01-2.63]).
Conclusions: The prevalence of CT infection among young male military conscripts was high, especially among men from upper northern Thailand. Multiple sexual partners, graduation from a vocational school, inconsistent condom use, unemployment before the military induction, and younger age were independently associated with the CT infection among young Thai men. These data will be useful to develop more effective public health interventions to prevent, detect, and treat sexually transmitted infections among young men in Thailand.
C1 [Jatapai, Anchalee] Phramongkutklao Coll Med, Off Res & Dev, Bangkok 10400, Thailand.
[Sirivongrangson, Pachara; Lokpichat, Somchai] Minist Publ Hlth, Dept Dis Control, Bur AIDS TB STIs, Bangkok, Thailand.
[Chuenchitra, Thippawan] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Nelson, Kenrad E.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
[Rangsin, Ram] Phramongkutklao Coll Med, Dept Mil & Community Med, Bangkok 10400, Thailand.
RP Rangsin, R (reprint author), Phramongkutklao Coll Med, Dept Mil & Community Med, 315 Ratchawithi Rd, Bangkok 10400, Thailand.
EM rrangsin@pmk.ac.th
FU National Institute of Health [5R01TW006972-04]; Ministry of Public
Health, Thailand
FX Supported by the National Institute of Health (No. 5R01TW006972-04) and
Ministry of Public Health, Thailand.
NR 27
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U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-5717
J9 SEX TRANSM DIS
JI Sex. Transm. Dis.
PD MAR
PY 2013
VL 40
IS 3
BP 241
EP 246
DI 10.1097/OLQ.0b013e31827e8de4
PG 6
WC Infectious Diseases
SC Infectious Diseases
GA 089KY
UT WOS:000314910600012
PM 23407469
ER
PT J
AU Convertino, M
Baker, KM
Vogel, JT
Lu, C
Suedel, B
Linkov, I
AF Convertino, M.
Baker, K. M.
Vogel, J. T.
Lu, C.
Suedel, B.
Linkov, I.
TI Multi-criteria decision analysis to select metrics for design and
monitoring of sustainable ecosystem restorations
SO ECOLOGICAL INDICATORS
LA English
DT Article
DE Multi-criteria decision analysis; Environmental metrics; Ecosystem
restoration; Monitoring; Stakeholder preferences, utility
ID NETHERLANDS; FRAMEWORK; SCIENCE; WORLD; MODEL; RISK; ART
AB The selection of metrics for ecosystem restoration programs is critical for improving the quality and utility of design and monitoring programs, informing adaptive management actions, and characterizing project success. The metrics selection process, that in practice is left to the subjective judgment of stakeholders, is often complex and should simultaneously take into account monitoring data, environmental models, socio-economic considerations, and stakeholder interests. With limited funding, it is often very difficult to balance the importance of multiple metrics, often competing, intended to measure different environmental, social, and economic aspects of the system. To help restoration planners and practitioners develop the most useful and informative design and monitoring programs, we propose the use of multi-criteria decision analysis (MCDA) methods, broadly defined, to select optimal ecosystem restoration metric sets. In this paper, we apply and compare two MCDA methods, multi-attribute utility theory (MAUT), and probabilistic multi-criteria acceptability analysis (ProMAA), for a hypothetical river restoration case study involving multiple stakeholders with competing interests. Overall, the MCDA results in a systematic, quantitative, and transparent evaluation and comparison of potential metrics that provides planners and practitioners with a clear basis for selecting the optimal set of metrics to evaluate restoration alternatives and to inform restoration design and monitoring. In our case study, the two MCDA methods provide comparable results in terms of selected metrics. However, because ProMAA can consider probability distributions for weights and utility values of metrics for each criterion, it is most likely the best option for projects with highly uncertain data and significant stakeholder involvement. Despite the increase in complexity in the metrics selection process, MCDA improves upon the current, commonly-used ad-hoc decision practice based on consultations with stakeholders by applying and presenting quantitative aggregation of data and judgment, thereby increasing the effectiveness of environmental design and monitoring and the transparency of decision making in restoration projects. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Convertino, M.] Univ Florida, Dept Agr & Biol Engn, Gainesville, FL USA.
[Convertino, M.] Univ Florida, Florida Climate Inst, Gainesville, FL USA.
[Baker, K. M.; Vogel, J. T.] USA, Corps Engineers, Risk & Decis Sci Team, Environm Lab,ERDC, Concord, MA USA.
[Lu, C.] MIT, Dept Civil & Environm Engn, Environm & Water Qual Program, Cambridge, MA 02139 USA.
[Suedel, B.; Linkov, I.] USA, Corps Engineers, Risk & Decis Sci Team, Environm Lab,ERDC, Vicksburg, MS 39180 USA.
[Linkov, I.] Carnegie Mellon Univ, Dept Engn & Publ Policy, Pittsburgh, PA 15213 USA.
RP Convertino, M (reprint author), Dept Agr & Biol Engn, Frazier Rogers Hall,Museum Rd,POB 110570, Gainesville, FL 32611 USA.
EM mconvertino@ufl.edu
FU Environmental Benefit Analysis Program of the U.S. Army Corps of
Engineers; DECERNS-SDSS; Engineering Research and Development Center,
U.S. Army Corps of Engineers, in Concord, MA, USA
FX The authors acknowledge the support of the Environmental Benefit
Analysis Program of the U.S. Army Corps of Engineers
(http://cw-environment.usace.army.mil/eba/). Dr. B. Yatsalo is
acknowledged for making a demonstration version of DECERNS-SDSS
available. D. Dokukin, and J.M. Keisler are kindly acknowledged for
their support with DECERNS-SDSS and for the basis of the theoretical
framework respectively. The Editor, Dr. F. Muller and two anonymous
reviewers are gratefully acknowledged for their constructive comments.
M.C. acknowledges the funding of project "Decision and Risk Analysis
Applications Environmental Assessment and Supply Chain Risks" for his
research at the Risk and Decision Science Team, Engineering Research and
Development Center, U.S. Army Corps of Engineers, in Concord, MA, USA.
C. Lu was BSc and MSc student at Massachusetts Institute of Technology,
and research intern at the Risk and Decision Science Group when this
research was performed. C. Lu is currently at AMEC Environment &
Infrastructure, Oakland, CA. Permission was granted by the U.S. Army
Corps of Engineers - Chief of Engineers to publish this material. The
views and opinions expressed in this paper are those of the individual
authors and not those of the U.S. Army, or other sponsoring
organizations.
NR 56
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Z9 20
U1 3
U2 85
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1470-160X
EI 1872-7034
J9 ECOL INDIC
JI Ecol. Indic.
PD MAR
PY 2013
VL 26
BP 76
EP 86
DI 10.1016/j.ecolind.2012.10.005
PG 11
WC Biodiversity Conservation; Environmental Sciences
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA 083RP
UT WOS:000314483200009
ER
PT J
AU Goswami, R
Holtz, RL
AF Goswami, Ramasis
Holtz, Ronald L.
TI Transmission Electron Microscopic Investigations of Grain Boundary Beta
Phase Precipitation in Al 5083 Aged at 373 K (100 degrees C)
SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND
MATERIALS SCIENCE
LA English
DT Article; Proceedings Paper
CT International Symposium on the Environmental Damage under Static and
Cyclic Loads in Structural Materials at Ambient Temperatures-II
CY AUG 14-19, 2011
CL Krakow, POLAND
ID STRESS-CORROSION CRACKING; SENSITIZED AA5083 AL-4.5MG-1.0MN; MG ALLOY;
ALUMINUM-ALLOYS; STRENGTHENING MECHANISMS; INTERGRANULAR CORROSION;
SEGREGATION; DIFFUSION; PARTICLES
AB The fine-scale microstructure of an Al 5083 alloy sensitized at 373 K (100 A degrees C) for 3, 7, 14, 30, 45, and 90 days has been investigated using transmission electron microscopy (TEM) to study the evolution of the beta phase (Al3Mg2) at grain boundaries. In fully sensitized Al 5083, the beta phase (Al3Mg2) mostly forms heterogeneously at grain boundaries. TEM observations showed that the grain boundary precipitation of beta phase was discrete up to 14 days of aging, and grain boundaries were fully covered by the beta phase after 30 to 45 days of aging. The early stages of beta growth on the grain boundaries are consistent with the collector-plate mechanism. We find no evidence of either Mg depletion or segregation at the grain boundaries. The initial growth rates as well as the thicknesses after long aging times are greater than can be accounted for by bulk diffusion of Mg to the grain boundaries. We suggest that dislocation pipe diffusion is necessary to account for the beta growth rates.
C1 [Goswami, Ramasis; Holtz, Ronald L.] USA, Res Lab, Washington, DC 20375 USA.
RP Goswami, R (reprint author), USA, Res Lab, Code 6351,4555 Overlook Ave SW, Washington, DC 20375 USA.
EM Ramasis.goswami@nrl.navy.mil
NR 48
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U1 3
U2 34
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1073-5623
EI 1543-1940
J9 METALL MATER TRANS A
JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci.
PD MAR
PY 2013
VL 44A
IS 3
BP 1279
EP 1289
DI 10.1007/s11661-012-1166-9
PG 11
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA 082BK
UT WOS:000314366500013
ER
PT J
AU Collins, PC
Koduri, S
Welk, B
Tiley, J
Fraser, HL
AF Collins, Peter C.
Koduri, Santhosh
Welk, Brian
Tiley, Jaimie
Fraser, Hamish L.
TI Neural Networks Relating Alloy Composition, Microstructure, and Tensile
Properties of alpha/beta-Processed TIMETAL 6-4
SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND
MATERIALS SCIENCE
LA English
DT Article; Proceedings Paper
CT International Symposium on the Environmental Damage under Static and
Cyclic Loads in Structural Materials at Ambient Temperatures-II
CY AUG 14-19, 2011
CL Krakow, POLAND
ID TITANIUM-ALLOYS; MECHANICAL-PROPERTIES; STRENGTH; GROWTH; STEELS;
EQUILIBRIUM; TI-6AL-4V; WELDS
AB Bayesian neural networks have been developed, which relate composition, microstructure, and tensile properties of the alloy TIMETAL 6-4 (nominal composition: Ti-6Al-4V (wt pct) after thermomechanical processing (TMP) in the two-phase (alpha + beta)-phase field. The developed networks are able to make interpolative predictions of properties within the ranges of composition and microstructural features that are in the population of the database used for training and testing of the networks. In addition, the neural networks have been used to conduct virtual experiments which permit the functional dependencies of properties on composition and microstructural features to be determined. In this way, it is shown that in the microstructural condition resulting from TMP in the two-phase (alpha + beta) phase field, the most significant contribution to strength is from solid solution strengthening, with microstructural features apparently influencing the balance of a number of properties.
C1 [Collins, Peter C.; Koduri, Santhosh; Welk, Brian; Fraser, Hamish L.] Ohio State Univ, Dept Mat Sci & Engn, Columbus, OH 43210 USA.
[Tiley, Jaimie] USA, Mat & Mfg Directorate, Res Lab, Dayton, OH USA.
RP Collins, PC (reprint author), Univ N Texas, Dept Mat Sci & Engn, Denton, TX 76203 USA.
EM Peter.Collins@unt.edu
RI Collins, Peter/A-4961-2016
OI Collins, Peter/0000-0002-3441-2981
FU Air Force Research Laboratory; Office of Naval Research; Metals
Affordability Initiative ("Microstructural and Mechanical Property Model
Development for Wrought Titanium Alloys"); ONR/DARPA D-3D Program
[N00014-05-1-0504]
FX The authors of this article would like to express their thanks to the
Air Force Research Laboratory and the Office of Naval Research for their
funding of the research programs which supported the current research,
including specifically the Metals Affordability Initiative
("Microstructural and Mechanical Property Model Development for Wrought
Titanium Alloys") and the ONR/DARPA D-3D Program ("Experimental and
computational tools for the digital representation and prediction of
microstructure and its incorporation in the designer's knowledge base,"
N00014-05-1-0504) which have led to the development of these databases
and neural networks. The authors would also like to thank the many
graduate students associated with the Center for the Accelerated
Maturation of Materials (CAMM) who characterized the material which has
been included in the databases.
NR 39
TC 11
Z9 11
U1 2
U2 28
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1073-5623
EI 1543-1940
J9 METALL MATER TRANS A
JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci.
PD MAR
PY 2013
VL 44A
IS 3
BP 1441
EP 1453
DI 10.1007/s11661-012-1498-5
PG 13
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA 082BK
UT WOS:000314366500028
ER
PT J
AU Olson, MA
Lee, MS
AF Olson, Mark A.
Lee, Michael S.
TI Structure refinement of protein model decoys requires accurate
side-chain placement
SO PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
LA English
DT Article
DE protein structure prediction; conformational sampling; Langevin
dynamics; molecular dynamics; statistical potential; structure
recognition
ID MOLECULAR-DYNAMICS SIMULATIONS; GUIDED LANGEVIN DYNAMICS;
HIGH-RESOLUTION REFINEMENT; I-TASSER; REPLICA-EXCHANGE; STATISTICAL
POTENTIALS; STRUCTURE PREDICTION; HOMOLOGY MODELS; FORCE; CASP9
AB In this study, the application of temperature-based replica-exchange (T-ReX) simulations for structure refinement of decoys taken from the I-TASSER dataset was examined. A set of eight nonredundant proteins was investigated using self-guided Langevin dynamics (SGLD) with a generalized Born implicit solvent model to sample conformational space. For two of the protein test cases, a comparison of the SGLD/T-ReX method with that of a hybrid explicit/implicit solvent molecular dynamics T-ReX simulation model is provided. Additionally, the effect of side-chain placement among the starting decoy structures, using alternative rotamer conformations taken from the SCWRL4 modeling program, was investigated. The simulation results showed that, despite having near-native backbone conformations among the starting decoys, the determinant of their refinement is side-chain packing to a level that satisfies a minimum threshold of native contacts to allow efficient excursions toward the downhill refinement regime on the energy landscape. By repacking using SCWRL4 and by applying the RWplus statistical potential for structure identification, the SGLD/T-ReX simulations achieved refinement to an average of 38% increase in the number of native contacts relative to the original I-TASSER decoy sets and a 25% reduction in values of Ca root-mean-square deviation. The hybrid model succeeded in obtaining a sharper funnel to low-energy states for a modeled target than the implicit solvent SGLD model; yet, structure identification remained roughly the same. Without meeting a threshold of near-native packing of side chains, the T-ReX simulations degrade the accuracy of the decoys, and subsequently, refinement becomes tantamount to the protein folding problem. Proteins 2013. 2012 Published by Wiley Periodicals, Inc.
C1 [Olson, Mark A.; Lee, Michael S.] USAMRIID, Dept Cell Biol & Biochem, Frederick, MD 21702 USA.
[Lee, Michael S.] USAMRIID, Ctr Genome Sci, Frederick, MD 21702 USA.
[Lee, Michael S.] USA, Computat Sci & Engn Branch, Res Lab, Aberdeen, MD 21005 USA.
RP Olson, MA (reprint author), USAMRIID, Dept Cell Biol & Biochem, Frederick, MD 21702 USA.
EM molson@compbiophys.org
FU U.S. Department of Defense Threat Reduction Agency
[TMTI0004_09_714_BH_T, CBCALL12-LS6-2-0036]
FX Grant sponsor: U.S. Department of Defense Threat Reduction Agency; Grant
numbers: TMTI0004_09_714_BH_T, CBCALL12-LS6-2-0036
NR 35
TC 8
Z9 8
U1 0
U2 17
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0887-3585
J9 PROTEINS
JI Proteins
PD MAR
PY 2013
VL 81
IS 3
BP 469
EP 478
DI 10.1002/prot.24204
PG 10
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA 079OI
UT WOS:000314179600010
PM 23070940
ER
PT J
AU Webb, CM
Estrada, A
Athy, JR
AF Webb, Catherine M.
Estrada, Arthur
Athy, Jeremy R.
TI Motion Sickness Prevention by an 8-Hz Stroboscopic Environment During
Air Transport
SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE
LA English
DT Article
DE Motion sickness; stroboscopic; airsickness; retinal slip
ID SLEEP-DEPRIVATION; EXPOSURE; VISION
AB Introduction: Previous research has shown that retinal slip can be a significant factor in causing motion sickness. Stroboscopic illumination may prevent retinal slip by providing snapshots of the visual environment that are brief enough so each image is stationary on the retina. Methods: The purpose of this study was to determine the effectiveness of an 8-Hz stroboscopic environment as a motion sickness countermeasure for passengers during a nauseogenic flight in a helicopter. The study population was comprised of 18 motion sickness susceptible subjects. Subjects completed a motion sickness symptom questionnaire, a psychomotor vigilance test, weapons utilization tasks, a time estimation task, and a sustained attention task after nauseogenic flights with and without 8-Hz stroboscopic illumination in the cabin. Results: Baseline-corrected scores of self-reported nausea were significantly lower after the stroboscopic condition (M = 36.57 +/- 6.95) than the nonstroboscopic condition (M = 50.88 +/- 7.36). Furthermore, the stroboscopic condition resulted in significantly better performance on the vigilance task than the nonstroboscopic condition. However, baseline-corrected scores of oculomotor symptoms were greater after the stroboscopic condition (M = 33.27 +/- 5.52) than the nonstroboscopic condition (M = 24.85 +/- 4.10). Discussion: These results support the use of stroboscopic illumination as a nonpharmacologic countermeasure for motion sickness related to retinal slip. However, due to the uncontrolled nature of the flights, the possibility that these results could have been influenced by differences in motion between flights cannot be excluded. This technology should be investigated in other forms of transportation (i.e., ground vehicles).
C1 [Webb, Catherine M.; Estrada, Arthur; Athy, Jeremy R.] US Army, Aeromed Res Lab, Fort Rucker, AL 36362 USA.
RP Webb, CM (reprint author), US Army, Aeromed Res Lab, POB 620577, Fort Rucker, AL 36362 USA.
EM catherine.webb@us.army.mil
FU Army Medical Department Advanced Medical Technology Initiative (AAMTI)
from the Telemedicine and Advanced Technology Research Center (TATRC)
FX This study was funded by the Army Medical Department Advanced Medical
Technology Initiative (AAMTI) from the Telemedicine and Advanced
Technology Research Center (TATRC). The opinions, interpretations,
conclusions, and recommendations contained in this report are those of
the authors and should not be construed as an official Department of the
Army position, policy, or decision, unless so designated by other
official documentation. Citation of trade names in this report does not
constitute an official Department of the Army endorsement or approval of
the use of such commercial items.
NR 23
TC 3
Z9 4
U1 0
U2 5
PU AEROSPACE MEDICAL ASSOC
PI ALEXANDRIA
PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA
SN 0095-6562
EI 1943-4448
J9 AVIAT SPACE ENVIR MD
JI Aviat. Space Environ. Med.
PD MAR
PY 2013
VL 84
IS 3
BP 177
EP 183
DI 10.3357/ASEM.3342.2013
PG 7
WC Public, Environmental & Occupational Health; Medicine, General &
Internal; Sport Sciences
SC Public, Environmental & Occupational Health; General & Internal
Medicine; Sport Sciences
GA AD1LP
UT WOS:000332995800001
PM 23513277
ER
PT J
AU Jennings, NA
AF Jennings, Nathan A.
TI Riding into Controversy: A Study in Contrasting Views of the Texas
Rangers
SO JOURNAL OF THE WEST
LA English
DT Article
RP Jennings, NA (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 39
TC 0
Z9 0
U1 0
U2 0
PU ABC-CLIO
PI SANTA BARBARA
PA 130 CREMONA DR, SANTA BARBARA, CA 93117 USA
SN 0022-5169
EI 1930-0115
J9 J WEST
JI J. West
PD SPR
PY 2013
VL 52
IS 2
BP 42
EP 52
PG 11
WC History
SC History
GA V39AM
UT WOS:000209383900006
ER
PT J
AU Dai, TH
Gupta, A
Huang, YY
Yin, R
Murray, C
Vrahas, M
Kielian, T
Hamblin, M
AF Dai, Tianhong
Gupta, Asheesh
Huang, Yingying
Yin, Rui
Murray, Clinton
Vrahas, Mark
Kielian, Tammy
Hamblin, Michael
TI BLUE LIGHT ELIMINATES COMMUNITY-ACQUIRED METHICILLIN-RESISTANT
STAPHYLOCOCCUS AUREUS IN INFECTED MOUSE SKIN ABRASIONS
SO LASERS IN SURGERY AND MEDICINE
LA English
DT Meeting Abstract
C1 Harvard Univ, Massachusetts Gen Hosp, Sch Med, Wellman Ctr Photomed, Boston, MA USA.
Brooke Army Med Ctr, Infect Dis Serv, Houston, TX USA.
Univ Nebraska Med Ctr, Omaha, NE USA.
NR 0
TC 1
Z9 1
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0196-8092
EI 1096-9101
J9 LASER SURG MED
JI Lasers Surg. Med.
PD MAR
PY 2013
VL 45
SU 25
MA 121
BP 41
EP 41
PG 1
WC Dermatology; Surgery
SC Dermatology; Surgery
GA V38YX
UT WOS:000209379800116
ER
PT J
AU Terrill, WA
AF Terrill, W. Andrew
TI A Quietist Jihadi: The Ideology and Influence of Abu Muhammad al-Maqdisi
SO MIDDLE EAST JOURNAL
LA English
DT Book Review
C1 [Terrill, W. Andrew] US Army War Coll, Strateg Studies Inst, Carlisle, PA USA.
RP Terrill, WA (reprint author), US Army War Coll, Strateg Studies Inst, Carlisle, PA USA.
NR 1
TC 0
Z9 0
U1 1
U2 1
PU MIDDLE EAST INST
PI WASHINGTON
PA 1761 N ST NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 USA
SN 0026-3141
J9 MIDDLE EAST J
JI Middle East J.
PD SPR
PY 2013
VL 67
IS 2
BP 332
EP 333
PG 2
WC Area Studies
SC Area Studies
GA AG2UT
UT WOS:000335273300024
ER
PT J
AU Radomski, MV
Weightman, MM
Davidson, LF
Finkelstein, M
Goldman, S
McCulloch, K
Roy, TC
Scherer, M
Stern, EB
AF Radomski, Mary Vining
Weightman, Margaret M.
Davidson, Leslie Freeman
Finkelstein, Marsha
Goldman, Sarah
McCulloch, Karen
Roy, Tanja C.
Scherer, Matthew
Stern, Erica B.
TI Development of a Measure to Inform Return-to-Duty Decision Making After
Mild Traumatic Brain Injury
SO MILITARY MEDICINE
LA English
DT Article
ID ECOLOGICAL VALIDITY; POSTURAL STABILITY; COGNITIVE TASKS; CONCUSSION;
GAIT; PERFORMANCE; ATTENTION; RECOVERY; DEFICITS; INTERFERENCE
AB Mild traumatic brain injury (mTBI), a principal injury of the wars in Iraq and Afghanistan, can result in significant morbidity. To make accurate return-to-duty decisions for soldiers with mTBI, military medical personnel require sensitive, objective, and duty-relevant data to characterize subtle cognitive and sensorimotor injury sequelae. A military-civilian research team reviewed existing literature and obtained input from stakeholders, end users, and experts to specify the concept and develop a preliminary assessment protocol to address this need. Results of the literature review suggested the potential utility of a test based on dual-task and multitask assessment methods. Thirty-three individuals representing a variety of military and civilian stakeholders/experts participated in interviews. Interview data suggested that reliability/validity, clinical feasibility, usability across treatment facilities, military face validity, and capacity to challenge mission-critical mTBI vulnerabilities were important to ultimate adoption. The research team developed the Assessment of Military Multitasking Performance, a tool composed of eight dual and multitasking test-tasks. A concept test session with 10 subjects indicated preliminary face validity and informed modifications to scoring and design. Further validation is needed. The Assessment of Military Multitasking Performance may fill a gap identified by stakeholders for complex cognitive/motor testing to assist return-to-duty decisions for service members with mTBI.
C1 [Radomski, Mary Vining; Weightman, Margaret M.; Finkelstein, Marsha] Sister Kenny Res Ctr, Minneapolis, MN 55407 USA.
[Davidson, Leslie Freeman] Shenandoah Univ, Div Occupat Therapy, Winchester, VA 22601 USA.
[Goldman, Sarah; Roy, Tanja C.; Scherer, Matthew] US Army Res Inst Environm Med, Natick, MA 01760 USA.
[McCulloch, Karen] Univ N Carolina, Sch Med, Div Phys Therapy, Chapel Hill, NC 27599 USA.
[Stern, Erica B.] Univ Minnesota, Ctr Allied Hlth Programs, Program Occupat Therapy, Minneapolis, MN 55455 USA.
RP Radomski, MV (reprint author), Sister Kenny Res Ctr, 800 East 28th St & Chicago Ave, Minneapolis, MN 55407 USA.
FU U.S. Army Medical Research and Materiel Command [W81XWH-09-2-0149]
FX The research team acknowledges the contribution of those interviewed and
the following partners and experts who have helped to shape the AMMP
protocol: Amanda Antczalc, MS; Kristin Heaton, PhD; Val Kelly PT, PhD;
Lynne M. Lowe, PT, DPT, OCS; Tracy Morrison, OTD, OTR/L; Lars Oddsson,
PhD; John Whyte, MD, PhD; and Tim Wolf, OTD, MSCI, OTR/L. This project
was funded by the U.S. Army Medical Research and Materiel Command (award
number W81XWH-09-2-0149).
NR 48
TC 6
Z9 6
U1 2
U2 7
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2013
VL 178
IS 3
BP 246
EP 253
DI 10.7205/MILMED-D-12-00144
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7TX
UT WOS:000340805000003
PM 23707109
ER
PT J
AU Gallaway, MS
Bell, MR
Lagana-Riordan, C
Fink, DS
Meyer, CE
Millikan, AM
AF Gallaway, M. Shayne
Bell, Michael R.
Lagana-Riordan, Christine
Fink, David S.
Meyer, Charles E.
Millikan, Amy M.
TI The Association Between US Army Enlistment Waivers and Subsequent
Behavioral and Social Health Outcomes and Attrition From Service
SO MILITARY MEDICINE
LA English
DT Article
AB Soldiers granted enlistment waivers for medical concerns, misconduct, or positive alcohol/drug tests may or may not be associated with an increased likelihood of negative behavioral outcomes. Soldiers in the population examined (n = 8,943) who were granted enlistment waivers from 2003 to 2008 were significantly more likely to subsequently be screened for alcohol/substance abuse, test positive for illicit substances, or receive an Army separation for behavioral misconduct. These associations were highest among Soldiers granted waivers for nonlawful alcohol/drug violations. Soldiers granted waivers for felony offenses and serious nontraffic violations were significantly less likely to separate from the Army compared with Soldiers not granted enlistment waivers.
C1 [Gallaway, M. Shayne; Lagana-Riordan, Christine; Fink, David S.; Meyer, Charles E.; Millikan, Amy M.] US Army, Inst Publ Hlth, Behav & Social Hlth Outcomes Program, Aberdeen Proving Ground, MD 21010 USA.
[Bell, Michael R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
RP Gallaway, MS (reprint author), US Army, Inst Publ Hlth, Behav & Social Hlth Outcomes Program, 5158 Blacichawk Rd,Bldg E-1570, Aberdeen Proving Ground, MD 21010 USA.
OI Fink, David/0000-0003-1531-1525
NR 20
TC 4
Z9 4
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2013
VL 178
IS 3
BP 261
EP 266
DI 10.7205/MILMED-D-12-00316
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7TX
UT WOS:000340805000005
PM 23707111
ER
PT J
AU Moore, AD
Hamilton, JB
Pierre-Louis, BJ
Jennings, BM
AF Moore, Angelo D.
Hamilton, Jill B.
Pierre-Louis, Bosny J.
Jennings, Bonnie M.
TI Increasing Access to Care and Reducing Mistrust: Important
Considerations When Implementing the Patient-Centered Medical Home in
Army Health Clinics
SO MILITARY MEDICINE
LA English
DT Article
ID MENTAL-HEALTH; SATISFACTION; VETERANS; DISCRIMINATION; RELIGION;
BELIEFS; SUPPORT; RACISM; MODEL
AB Objective: To determine which individual characteristics (religious participation, mistrust, racism/discrimination, spirituality, perceived access to care, and continuity of care) were predictors of patient outcomes (patient satisfaction, physical health, and mental health status) for an Army health care clinic transitioning to the Patient-Centered Medical Home (PCMH). Method: A descriptive, correlational design using stepwise multivariate regression analyses to assess the effect of individual characteristics on patient outcomes for 200 Army Soldiers and family members receiving health care services. Results: Perceived access to care was positively and mistrust was negatively related to patient satisfaction (p < 0.001 for both variables). Participants who reported more support from God and more mistrust also reported poorer physical health status (p < 0.008 and p < 0.003, respectively). Perceived access to care was the only individual characteristic that showed a significant (p < 0.019) positive association with a better mental health status. Conclusion: This study suggests that better access to care improves patient satisfaction and mental health status; however, those with higher levels of mistrust tend to have lower patient satisfaction and poorer health. Participants with poorer health also tend to rely on more support from God. These important individual characteristics should be the considered when implementing the PCMH.
C1 [Moore, Angelo D.] Tripler Army Med Ctr, Ctr Nursing Sci & Clin Inquiry, Honolulu, HI 96859 USA.
[Hamilton, Jill B.] Univ N Carolina, Sch Nursing, Chapel Hill, NC 27599 USA.
[Pierre-Louis, Bosny J.] Nov Analyt, Durham, NC 27713 USA.
[Jennings, Bonnie M.] Emory Univ, Nell Hodgson Woodruff Sch Nursing, Atlanta, GA 30322 USA.
RP Moore, AD (reprint author), Tripler Army Med Ctr, Ctr Nursing Sci & Clin Inquiry, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
FU TriService Nursing Research Program, Uniformed Services University of
the Health Sciences [N11-P05]
FX We thank Jessica L. Krusel for her assistance in this research project.
We also thank the leadership and staff at the clinic and Exchange
(formally Army Air Force Exchange Services) for assisting with obtaining
all necessary approvals and accommodating sites needed for recruiting
participants for this research study. This research study was funded by
the TriService Nursing Research Program (grant N11-P05), Uniformed
Services University of the Health Sciences.
NR 42
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Z9 5
U1 2
U2 6
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2013
VL 178
IS 3
BP 291
EP 298
DI 10.7205/MILMED-D-12-00443
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7TX
UT WOS:000340805000010
PM 23707116
ER
PT J
AU Bastian, ND
Brown, D
Fulton, LV
Mitchell, R
Pollard, W
Robinson, M
Wilson, R
AF Bastian, Nathaniel D.
Brown, David
Fulton, Lawrence V.
Mitchell, Robert
Pollard, Wayne
Robinson, Mark
Wilson, Ronald
TI Analyzing the Future of Army Aeromedical Evacuation Units and Equipment:
A Mixed Methods, Requirements-Based Approach
SO MILITARY MEDICINE
LA English
DT Article
AB We utilize a mixed methods approach to provide three new, separate analyses as part of the development of the next aeromedical evacuation (MEDEVAC) platform of the Future of Vertical Lift (FVL) program. The research questions follow: RQ1) What are the optimal capabilities of a FVL MEDEVAC platform given an Afghanistan-like scenario and parameters associated with the treatment/ground evacuation capabilities in that theater?; RQ2) What are the MEDEVAC trade-off considerations associated with different aircraft engines operating under variable conditions?; RQ3) How does the additional weight of weaponizing the current MEDEVAC fleet affect range, coverage radius, and response time? We address RQ1 using discrete-event simulation based partially on qualitative assessments from the field, while RQ2 and RQ3 are based on deterministic analysis. Our results confirm previous findings that travel speeds in excess of 250 knots and ranges in excess of 300 nautical miles are advisable for the FVL platform design, thereby reducing the medical footprint in stability operations. We recommend a specific course of action regarding a potential engine bridging strategy based on deterministic analysis of endurance and altitude, and we suggest that the weaponization of the FVL MEDEVAC aircraft will have an adverse effect on coverage capability.
C1 [Bastian, Nathaniel D.] US Army Med Dept Ctr & Sch, Ctr AMEDD Strateg Studies, Med Capabil Integrat Ctr, Ft Sam Houston, TX 78234 USA.
[Brown, David; Pollard, Wayne; Wilson, Ronald] Navigator Dev Grp Inc, Enterprise, AL 36330 USA.
[Fulton, Lawrence V.] Texas State Univ, McCoy Coll Business Adm, Dept Comp Informat Syst & Quantitat Methods, San Marcos, TX 78666 USA.
[Robinson, Mark] US Army Med Dept Ctr & Sch, Med Capabil Integrat Ctr, Med Evacuat Proponency Directorate, Ft Rucker, AL 36362 USA.
RP Bastian, ND (reprint author), US Army Med Dept Ctr & Sch, Ctr AMEDD Strateg Studies, Med Capabil Integrat Ctr, 1608 Stanley Rd, Ft Sam Houston, TX 78234 USA.
FU Medical Evacuation Proponency Directorate of the Medical Capabilities
Integration Center of the U.S. Army Medical Department Center School
FX We thank the Medical Evacuation Proponency Directorate of the Medical
Capabilities Integration Center of the U.S. Army Medical Department
Center & School who funded the research and analysis of this study.
NR 14
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U1 1
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2013
VL 178
IS 3
BP 321
EP 329
DI 10.7205/MILMED-D-12-00370
PG 9
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7TX
UT WOS:000340805000014
PM 23707120
ER
PT J
AU Aaron, CL
Fotinos, MJ
West, KB
Goodwin, DJ
Mancuso, JD
AF Aaron, Christopher L.
Fotinos, Meletios J.
West, Kevin B.
Goodwin, Donald J.
Mancuso, James D.
TI Tuberculosis Among Nonimmigrant Visitors to US Military Installations
SO MILITARY MEDICINE
LA English
DT Article
ID FOREIGN-BORN PERSONS; UNITED-STATES
AB Background: Nonimmigrant visitors are not required to be evaluated for tuberculosis (TB) before entering the country. Little literature exists describing the challenges of TB control among this demographic. This report reviews the challenges in managing TB in this population on U.S. military installations. Methods: Six cases were identified from reportable medical event reports. Information was obtained from public health personnel via phone interviews. Verified cases from 2004 to 2011 were included. Results: Challenges were congruent among locations including: lack of procedures to screen for infection and disease among individuals at time of entry allowing one case to be admitted with acquired immunodeficiency syndrome and another concurrently on treatment for active TB; delays in the diagnosis of active TB as median time from entry to diagnosis was 62 days; and the need to conduct an effective contact investigation as the mean contact index was 77 including 1 secondary case of active TB. Conclusions: These cases emphasize the, need for screening for TB in visitors from high-risk countries at time of entry, prompt diagnosis and treatment if found, procedures for evaluation of contacts, and interjurisdictional cooperation in large contact investigations. These challenges are common to nonimmigrants in both military and civilian settings.
C1 [Aaron, Christopher L.] Walter Reed Army Inst Res, Prevent Med Branch, Silver Spring, MD 20910 USA.
[Fotinos, Meletios J.] Global Hlth Engagement Branch AFMSA SGXI, Lackland AFB, TX 78236 USA.
[West, Kevin B.] Wilford Hall USAF Med Ctr, Reid Clin, Lackland AFB, TX 78236 USA.
[Goodwin, Donald J.] USAF Sch Aerosp Med, Wright Patterson AFB, OH 45433 USA.
[Mancuso, James D.] Walter Reed Army Inst Res, Prevent Med Branch, Silver Spring, MD 20910 USA.
RP Aaron, CL (reprint author), Walter Reed Army Inst Res, Prevent Med Branch, 2460 Linden Lane,Bldg 509,Off 110, Silver Spring, MD 20910 USA.
FU Preventive Medicine Residency [11]; Walter Reed Army Institute of
Research, Silver Spring, Maryland
FX This study was funded by Preventive Medicine Residency, Program 11,
Walter Reed Army Institute of Research, Silver Spring, Maryland.
NR 13
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U1 0
U2 1
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2013
VL 178
IS 3
BP 346
EP 352
DI 10.7205/MILMED-D-12-00297
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7TX
UT WOS:000340805000018
PM 23707124
ER
PT J
AU Smith, R
AF Smith, Roger
TI Wild West Innovation
SO RESEARCH-TECHNOLOGY MANAGEMENT
LA English
DT Editorial Material
C1 [Smith, Roger] Florida Hosp, Nicholson Ctr Surg Adv, Orlando, FL 32803 USA.
[Smith, Roger] US Army Simulat, Orlando, FL USA.
[Smith, Roger] Titan Corp, San Diego, CA USA.
[Smith, Roger] BTG Inc, Jacksonville, FL USA.
RP Smith, R (reprint author), Florida Hosp, Nicholson Ctr Surg Adv, Orlando, FL 32803 USA.
EM roger.smith@flhosp.org
NR 1
TC 0
Z9 0
U1 0
U2 0
PU INDUSTRIAL RESEARCH INST, INC
PI ARLINGTON
PA 2200 CLARENDON BLVD, STE 1102, ARLINGTON, VA 22201 USA
SN 0895-6308
EI 1930-0166
J9 RES TECHNOL MANAGE
JI Res.-Technol. Manage.
PD MAR-APR
PY 2013
VL 56
IS 2
BP 56
EP 57
DI 10.5437/08956308X5602007
PG 2
WC Business; Engineering, Industrial; Management
SC Business & Economics; Engineering
GA AI8XO
UT WOS:000337210500012
ER
PT J
AU Burns, DS
Cory, MG
Taylor, DE
Bunte, SW
Runge, K
Vasey, JL
AF Burns, Douglas S.
Cory, Marshall G.
Taylor, Decarlos E.
Bunte, Steven W.
Runge, Keith
Vasey, Joseph L.
TI A Comparison of Primary and Secondary Hydrogen Abstraction from
Organophosphates by Hydroxyl Radical
SO INTERNATIONAL JOURNAL OF CHEMICAL KINETICS
LA English
DT Article
ID GAS-PHASE REACTIONS; DIRECT DYNAMICS CALCULATIONS; MOLECULAR-ORBITAL
METHODS; ATMOSPHERIC CHEMISTRY; TRIETHYL PHOSPHATE; RATE CONSTANTS; OH
RADICALS; METHYLPHOSPHONATE; SURFACES; KINETICS
AB To compare the effect of primary and secondary C?H bonds on hydrogen?atom abstraction by hydroxyl radical, rate constants for the reactions of OH radicals with trimethyl phosphate [TMPO, (CH3O)3P(O)] and triethyl phosphate [TEPO, (CH3CH2O)3P(O)] have been calculated using the semiclassical fluxflux autocorrelation function (SCFFAF) method and compared with experimental measurements over the temperature range 250350K. SCFFAF specifies that structures be obtained at the CCSD/6?31++G** level of chemical theory and the height of the activation barrier be determined using an energy extrapolation, here a variant of the G2MP2 method. Dynamics are generated in the SCFFAF method from forces computed with a transfer Hamiltonian, which provides information about the curvature of the potential energy surface in the neighborhood of the transition state (TS), as well as the required internal forces. The temperature?dependent reaction rate constants are calculated for the various possible abstraction pathways, primary hydrogen atom abstraction in the case of TMPO, and primary and secondary in the case of TEPO. Since two energetically favorable parent structures for each system are included in the model, the activation energy is calculated with respect to the conformer that connects to a given TS and the total rate constant at a given temperature is Boltzmann weighted with respect to the parent conformer. The computed temperature?dependent rate curves are consistent with published experimental data in both magnitude and temperature dependence. (C) 2013 Wiley Periodicals, Inc. Int J Chem Kinet 45: 187201, 2013
C1 [Burns, Douglas S.; Cory, Marshall G.; Vasey, Joseph L.] ENSCO Inc, Melbourne, FL 32940 USA.
[Taylor, Decarlos E.; Bunte, Steven W.] USA, Res Lab, Weap & Mat Res Directorate, RDRL WMB D, Aberdeen Proving Ground, MD 21005 USA.
[Runge, Keith] BWD Associates LLC, Gainesville, FL 32653 USA.
RP Burns, DS (reprint author), ENSCO Inc, Melbourne, FL 32940 USA.
EM burns.douglas@ensco.com
FU U.S. Air Force
FX This work was supported by the U.S. Air Force.
NR 36
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U1 0
U2 28
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0538-8066
EI 1097-4601
J9 INT J CHEM KINET
JI Int. J. Chem. Kinet.
PD MAR
PY 2013
VL 45
IS 3
BP 187
EP 201
DI 10.1002/kin.20755
PG 15
WC Chemistry, Physical
SC Chemistry
GA 076WY
UT WOS:000313991100006
ER
PT J
AU Nie, X
Sanborn, B
Weerasooriya, T
Chen, WN
AF Nie, Xu
Sanborn, Brett
Weerasooriya, Tusit
Chen, Weinong
TI High-rate bulk and shear responses of bovine brain tissue
SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING
LA English
DT Article
DE Brain tissue; High strain rate; Shear response; Rate effects; Kolsky bar
ID ELASTOHYDRODYNAMIC LUBRICANTS; MECHANICAL-BEHAVIOR; SOFT MATERIALS;
COMPRESSIBILITY; INERTIA; TIME
AB This experimental study systematically investigates the dynamic response of bovine brain tissue under uniaxial strain and pure shear loading conditions. The combination of such stress states and strain rates are representative in the brain under blast loading in which both bulk and shear deformation may be involved. The dynamic uniaxial strain experiments (bulk response) were conducted on a modified Kolsky compression bar with an aluminum confinement collar. Bovine brain samples were sealed in the collar and loaded by the Kolsky bars so that the specimen only deformed in the axial direction. The resultant stress-strain curves reflected the pressure-volume relations from which the bulk modulus were obtained. The dynamic shear response was determined by using a recently developed Kolsky torsion bar technique for tissue materials characterization. Quasi-static torsion experiments were also conducted on an MTS system to construct a full set of shear stress-strain curves over a wide range of shear strain rates (0.01-700 s(-1)). The experimental results show that the dynamic bulk modulus of brain is in the range of 1.68-2.33 GPa which is close to the low rate values reported in the literature, while the shear responses show significant rate sensitivity over the tested strain rate range. (c) 2012 Elsevier Ltd. All rights reserved.
C1 [Nie, Xu] Univ N Texas, Dept Mech & Energy Engn, Denton, TX 76203 USA.
[Chen, Weinong] Purdue Univ, Sch Aeronaut Astronaut & Mat Engn, W Lafayette, IN 47907 USA.
[Sanborn, Brett; Weerasooriya, Tusit] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Chen, WN (reprint author), Purdue Univ, Sch Aeronaut Astronaut & Mat Engn, W Lafayette, IN 47907 USA.
EM wchen@purdue.edu
NR 31
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U1 0
U2 22
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0734-743X
J9 INT J IMPACT ENG
JI Int. J. Impact Eng.
PD MAR
PY 2013
VL 53
SI SI
BP 56
EP 61
DI 10.1016/j.ijimpeng.2012.07.012
PG 6
WC Engineering, Mechanical; Mechanics
SC Engineering; Mechanics
GA 077FD
UT WOS:000314012400007
ER
PT J
AU Kotan, H
Darling, KA
Saber, M
Scattergood, RO
Koch, CC
AF Kotan, Hasan
Darling, Kris A.
Saber, Mostafa
Scattergood, Ronald O.
Koch, Carl C.
TI An in situ experimental study of grain growth in a nanocrystalline
Fe91Ni8Zr1 alloy
SO JOURNAL OF MATERIALS SCIENCE
LA English
DT Article
ID THERMAL-STABILITY; SOLUTE SEGREGATION; STABILIZATION; STEEL
AB Grain growth and microstructural evolution of thermally stabilized Fe91Ni8Zr1 were investigated by in situ and ex situ studies. Our investigations suggest that the microstructural evolution is fairly slow and the microstructure shows stabilization up to about 700 A degrees C. Above this temperature, a certain fraction of grains grow abnormally into the nanocrystalline matrix, resulting in a bimodal microstructure and causing the complete loss of thermal stability. The reason for abnormal grain growth and the loss of thermal stability is identified as the appearance of the fcc gamma-phase and consequent reduction in the total area of grain boundaries and the overall stored energy.
C1 [Kotan, Hasan; Saber, Mostafa; Scattergood, Ronald O.; Koch, Carl C.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA.
[Darling, Kris A.] USA, Res Lab, Weap & Mat Res Directorate, RDRL WMM F, Aberdeen, MD 21005 USA.
RP Kotan, H (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, 911 Partners Way,Room 3002, Raleigh, NC 27695 USA.
EM hkotan@ncsu.edu
OI Saber, Mostafa/0000-0002-6763-8637
FU NSF-DMR [1005677]
FX The research reported in this paper was supported by NSF-DMR under grant
number 1005677.
NR 30
TC 12
Z9 12
U1 2
U2 38
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0022-2461
J9 J MATER SCI
JI J. Mater. Sci.
PD MAR
PY 2013
VL 48
IS 5
BP 2251
EP 2257
DI 10.1007/s10853-012-7002-1
PG 7
WC Materials Science, Multidisciplinary
SC Materials Science
GA 062GC
UT WOS:000312906400045
ER
PT J
AU Guo, JS
Zhou, J
Chu, D
Chen, RR
AF Guo, Junsong
Zhou, Jie
Chu, Deryn
Chen, Rongrong
TI Tuning the Electrochemical Interface of Ag/C Electrodes in Alkaline
Media with Metallophthalocyanine Molecules
SO JOURNAL OF PHYSICAL CHEMISTRY C
LA English
DT Article
ID MEMBRANE FUEL-CELLS; ANION-EXCHANGE MEMBRANE; OXYGEN REDUCTION REACTION;
DENSITY-FUNCTIONAL THEORY; PERFORMANCE; CATALYSTS; PLATINUM; SURFACES;
ELECTROCATALYSIS; NANOPARTICLES
AB Transition metal phthalocyanine (MPc) molecules were shown to be able to modify the electrochemical interface of the Ag catalyst in the alkaline electrolyte. Depending on the binding strength of the MPc (M = Fe, Co, Ni, and Mn) molecules with the OH- species, the electrochemically active sites of the Ag electrode surfaces can be altered accordingly. A structural model for illustrating the electrochemical interface of the Ag/C catalysts modified by the MPc molecules in alkaline media is proposed, which can be used to elucidate the ORR kinetics observed on various MPc@Ag/C catalysts in AEMFCs. The optimal CoPc-OH and Ag-CoPc interactions resulted in the highest kinetic current density and power density (536 mW cm(-2) at 50 degrees C) observed with the AEMFCs using Co Pc modified Ag/C cathode catalysts in comparison with the Ag/C and other MPc (M = Fe, Ni, and Mn) modified Ag/C catalysts
C1 [Guo, Junsong; Zhou, Jie; Chen, Rongrong] Indiana Univ Purdue Univ, Richard G Lugar Ctr Renewable Energy, Indianapolis, IN 46202 USA.
[Chu, Deryn] USA, Res Lab, Adelphi, MD 20783 USA.
RP Chen, RR (reprint author), Indiana Univ Purdue Univ, Richard G Lugar Ctr Renewable Energy, Indianapolis, IN 46202 USA.
EM rochen@iupui.edu
FU U.S. Army Research Lab [W911NF-10-2-0075]
FX This work was supported by the U.S. Army Research Lab
(W911NF-10-2-0075).
NR 39
TC 8
Z9 9
U1 2
U2 56
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1932-7447
J9 J PHYS CHEM C
JI J. Phys. Chem. C
PD FEB 28
PY 2013
VL 117
IS 8
BP 4006
EP 4017
DI 10.1021/jp310655y
PG 12
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA 134LN
UT WOS:000318211800036
ER
PT J
AU Valiyaveettil, M
Alamneh, Y
Wang, Y
Arun, P
Oguntayo, S
Wei, YL
Long, JB
Nambiar, MP
AF Valiyaveettil, Manojkumar
Alamneh, Yonas
Wang, Ying
Arun, Peethambaran
Oguntayo, Samuel
Wei, Yanling
Long, Joseph B.
Nambiar, Madhusoodana P.
TI Contribution of systemic factors in the pathophysiology of repeated
blast-induced neurotrauma
SO NEUROSCIENCE LETTERS
LA English
DT Article
DE Repeated blast exposure; Platelets; Leukocytes; Systemic factors;
Traumatic brain injury
ID TRAUMATIC BRAIN-INJURY; LYSOPHOSPHATIDIC ACID; SUICIDAL-BEHAVIOR;
INTRACRANIAL-PRESSURE; NERVOUS-SYSTEM; SEROTONIN; MYELOPEROXIDASE;
PLATELETS; MODEL; OVERPRESSURE
AB Blast-induced traumatic brain injury is complex and involves multiple factors including systemic pathphysiological factors in addition to direct brain injuries. We hypothesize that systemic activation of platelets/leukocytes plays a major role in the development and exacerbation of brain injury after blast exposure. A mouse model of repeated blast exposure that results in significant neuropathology, neurobehavioral changes and regional specific alterations in various biomolecules in the brain was used for the proposed study. Activation of platelets was evaluated by flow cytometry and serotonin content was analyzed by ELISA. Expression of myeloperoxidase was analyzed by Western blotting. Histopathology of the brain was used to assess blast-induced cerebral vasoconstriction. The data showed an increase in the activation of platelets at 4 h after repeated blast exposures, indicating changes in platelet phenotype in blast neurotrauma. Platelet serotonin concentration showed a significant decrease at 4 h after blast with a concurrent increase in the plasma serotonin levels, confirming the early onset of platelet activation after repeated blast exposures. Blood, plasma and brain myeloperoxidase enzyme activity and expression was increased in repeated blast exposed mice at multiple time points. Histopathological analysis of the brains of blast exposed mice showed constriction of blood vessels compared to the respective controls, a phenomenon similar to the reported cerebral vasoconstriction in blast affected victims. These results suggest that repeated blast exposure leads to acute activation of platelets/leukocytes which can augment the pathological effects of brain injury. Platelet/leukocyte targeted therapies can be evaluated as potential acute treatment strategies to mitigate blast-induced neurotrauma. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
C1 [Valiyaveettil, Manojkumar; Alamneh, Yonas; Wang, Ying; Arun, Peethambaran; Oguntayo, Samuel; Wei, Yanling; Long, Joseph B.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Blast Induced Neurotrauma Branch, Silver Spring, MD 20910 USA.
RP Valiyaveettil, M (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Blast Induced Neurotrauma Branch, Silver Spring, MD 20910 USA.
EM m.valiyaveettil@us.army.mil; madhunambiar1@gmail.com
NR 31
TC 8
Z9 8
U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0304-3940
J9 NEUROSCI LETT
JI Neurosci. Lett.
PD FEB 28
PY 2013
VL 539
BP 1
EP 6
DI 10.1016/j.neulet.2013.01.028
PG 6
WC Neurosciences
SC Neurosciences & Neurology
GA 120FJ
UT WOS:000317155900001
PM 23370286
ER
PT J
AU Underwood, T
Roy, S
Glaz, B
AF Underwood, Thomas
Roy, Subrata
Glaz, Bryan
TI Physics based lumped element circuit model for nanosecond pulsed
dielectric barrier discharges
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
AB This work presents a physics based circuit model for calculating the total energy dissipated into neutral species for nanosecond pulsed direct current (DC) dielectric barrier discharge (DBD) plasmas. Based on experimental observations, it is assumed that the nanosecond pulsed DBD's which have been proposed for aerodynamic flow control can be approximated by two independent regions of homogeneous electric field. An equivalent circuit model is developed for both homogeneous regions based on a combination of a resistor, capacitors, and a zener diode. Instead of fitting the resistance to an experimental data set, a formula is established for approximating the resistance by modeling plasmas as a conductor with DC voltage applied to it. Various assumptions are then applied to the governing Boltzmann equation to approximate electrical conductivity values for weakly ionized plasmas. The developed model is then validated with experimental data of the total power dissipated by plasmas. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4792665]
C1 [Underwood, Thomas; Roy, Subrata] Univ Florida, Appl Phys Res Grp, Dept Mech & Aerosp Engn, Gainesville, FL 32611 USA.
[Glaz, Bryan] USA, Vehicle Technol Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Underwood, T (reprint author), Univ Florida, Appl Phys Res Grp, Dept Mech & Aerosp Engn, Gainesville, FL 32611 USA.
EM roy@ufl.edu
RI Roy, Subrata/A-7493-2009
FU US Army Research Laboratory
FX The first author's work was partially supported by an undergraduate
internship at the US Army Research Laboratory.
NR 12
TC 2
Z9 4
U1 1
U2 16
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0021-8979
J9 J APPL PHYS
JI J. Appl. Phys.
PD FEB 28
PY 2013
VL 113
IS 8
AR 083301
DI 10.1063/1.4792665
PG 11
WC Physics, Applied
SC Physics
GA 100AQ
UT WOS:000315667500007
ER
PT J
AU Behler, KD
Ciezak-Jenkins, JA
Sausa, RC
AF Behler, K. D.
Ciezak-Jenkins, J. A.
Sausa, R. C.
TI High-Pressure Characterization of Nitrogen-Rich Bis-triaminoguanidinium
Azotetrazolate (TAGzT) by In Situ Raman Spectroscopy
SO JOURNAL OF PHYSICAL CHEMISTRY A
LA English
DT Article
ID DIAMOND-ANVIL CELL; ENERGETIC MATERIALS; SALTS; CALIBRATION; PROPELLANT;
MOLECULES; COMPOUND
AB Compounds rich in nitrogen are attracting significant interest not only because of their high energy content but also because they are potentially more environmentally benign in comparison to conventional energetic materials. Given this interest, it is desirable to understand their molecular composition and structural variations with pressure to derive their stability and determine the conditions in which they transform physically or chemically. In this study, we examine the room-temperature isothermal compression behavior of bis-triaminoguanidinium azotetrazolate (TAGzT) by in situ Raman spectroscopy to pressures near 17 GPa. We assign the characteristic vibrational bands and report the effects of pressure on band intensity, line width, and frequency shift Two prominent peaks near 1370 and 1470 cm(-1) arise from the C-N and N=N symmetric stretches, respectively. Overall, the intensity of these bands and others diminishes with pressure, and their spectral linewidths increase monotonically upon compression. The vibrational frequency modes blue shift linearly upon compression, indicating a generalized stiffening of the bonds as the pressure increases. These results, together with micro Raman spectroscopic analyses of the recovered, decompressed samples, suggest that TAGzT does not undergo any phase transitions within this pressure range. We estimate and report the C-N and N=N intermolecular bond lengths under compression.
C1 [Behler, K. D.] USA, Res Lab, RDRL WMM A, Aberdeen Proving Ground, MD 21005 USA.
[Ciezak-Jenkins, J. A.; Sausa, R. C.] USA, Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA.
RP Sausa, RC (reprint author), USA, Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA.
EM rosario.c.sausa.civ@mail.mil
FU ARL-BST Program
FX We thank Dr. E. Byrd of the Army Research Laboratory (ARL) for the
quantum mechanical bond energy calculations of TAGzT and Dr. J. Sloan
and Ms. J. Leadore of ARL for helpful discussions regarding the micro
Raman spectrometer. Also, we thank Dr. T. Jenkins of ARL for assistance
with the Raman apparatus used in the high-pressure measurements and Dr.
C. Michienzi of the Naval Surface Warfare Center for providing us with
polycrystalline TAGzT. Dr. K. Behler is a Bowhead Science and Technology
(BST) Senior Scientist at ARL and he gratefully acknowledges support
from the ARL-BST Program.
NR 38
TC 6
Z9 6
U1 2
U2 25
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1089-5639
J9 J PHYS CHEM A
JI J. Phys. Chem. A
PD FEB 28
PY 2013
VL 117
IS 8
BP 1737
EP 1743
DI 10.1021/jp311463g
PG 7
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA 100NL
UT WOS:000315707800007
PM 23343336
ER
PT J
AU Wang, S
Bromberg, L
Schreuder-Gibson, H
Hatton, TA
AF Wang, Sa
Bromberg, Lev
Schreuder-Gibson, Heidi
Hatton, T. Alan
TI Organophophorous Ester Degradation by Chromium(III) Terephthalate
Metal-Organic Framework (MIL-101) Chelated to N,N-Dimethylaminopyridine
and Related Aminopyridines
SO ACS APPLIED MATERIALS & INTERFACES
LA English
DT Article
DE metal-organic framework; aminopyridines; catalysis; organophosphorous
ester hydrolysis; paraoxon
ID LEWIS-BASE ACTIVATION; CATALYTIC-PROPERTIES; CARBON-DIOXIDE; REACTIVITY;
CENTERS; ENCAPSULATION; COMPOSITES; HYDROLYSIS; STABILITY; EFFICIENT
AB Porous materials based on chromium(III) terephthalate metal organic frameworks (MOF) MIL-101(Cr) and their complexes with dialkylaminopyridines (DAAP) were synthesized via a DAAP-MOF complexation, and tested for hydrolytic degradation of organophosphorous esters such as diethyl 4-nitrophenyl phosphate (paraoxon). Elemental analysis, TGA, XRD, FT-IR, TEM, SEM, and nitrogen adsorption measurements indicated that the DAAP units were incorporated into MIL-101 pores by complexation, keeping the parent framework intact. The DAAP-MOF enabled facile paraoxon hydrolysis in water/acetonitrile mixtures under ambient conditions (100% conversion after 24 h at pH 10). The MOF-DAAP complexes showed synergistic effects, being 7-fold and 47-fold more active than the parent MIL-101 or DAAP materials, respectively. The high hydrolysis reaction turnover was realized by simultaneous action of the Lewis acid Cr(III) center of the MOF as well as the electron-rich nucleophile, DAAP. This study demonstrates a simple and efficient method of generating catalytically active MOP materials for environmental detoxification as well as defensive applications.
C1 [Wang, Sa; Bromberg, Lev; Hatton, T. Alan] MIT, Dept Chem Engn, Cambridge, MA 02139 USA.
[Schreuder-Gibson, Heidi] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA.
RP Hatton, TA (reprint author), MIT, Dept Chem Engn, Cambridge, MA 02139 USA.
EM tahatton@mit.edu
FU Defense Threat Reduction Agency [HDTR1-09-1-0012]
FX The authors acknowledge the financial support from the Defense Threat
Reduction Agency grant HDTR1-09-1-0012. The authors are grateful to Dr.
Scott. A. Speakman for help with XRD results interpretation.
NR 63
TC 24
Z9 24
U1 6
U2 120
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1944-8244
J9 ACS APPL MATER INTER
JI ACS Appl. Mater. Interfaces
PD FEB 27
PY 2013
VL 5
IS 4
BP 1269
EP 1278
DI 10.1021/am302359b
PG 10
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
SC Science & Technology - Other Topics; Materials Science
GA 099KE
UT WOS:000315619100014
PM 23339453
ER
PT J
AU Lee, SY
Walsh, GF
Dal Negro, L
AF Lee, Sylvanus Y.
Walsh, Gary F.
Dal Negro, Luca
TI Microfluidics integration of aperiodic plasmonic arrays for
spatial-spectral optical detection
SO OPTICS EXPRESS
LA English
DT Article
ID IMAGE CORRELATION SPECTROSCOPY; HIGH-DENSITY NANOSTRUCTURES; METAL
NANOPARTICLES; CRITICAL MODES; SILK FILMS; FABRICATION; BIOSENSORS;
LITHOGRAPHY; SCATTERING; SURFACES
AB We demonstrate successful integration of aperiodic arrays of metal nanoparticles with microfluidics technology for optical sensing using the spectral-colorimetric responses of nanostructured arrays to refractive index variations. Different aperiodic arrays of gold (Au) nanoparticles with varying interparticle separations and Fourier spectral properties are fabricated using Electron Beam Lithography (EBL) and integrated with polydimethylsiloxane (PDMS) microfluidics structures by soft-lithographic micro-imprint techniques. The spectral shifts of scattering spectra and the distinctive modifications of structural color patterns induced by refractive index variations were simultaneously measured inside microfluidic flow cells by dark-field spectroscopy and image correlation analysis in the visible spectral range. The integration of engineered aperiodic arrays of Au nanoparticles with microfluidics devices provides a novel sensing platform with multiplexed spatial-spectral responses for opto-fluidics applications and lab-on-a-chip optical biosensing. (C) 2013 Optical Society of America
C1 [Lee, Sylvanus Y.; Walsh, Gary F.; Dal Negro, Luca] Boston Univ, Dept Elect & Comp Engn, Boston, MA 02215 USA.
[Lee, Sylvanus Y.; Walsh, Gary F.; Dal Negro, Luca] Boston Univ, Photon Ctr, Boston, MA 02215 USA.
[Lee, Sylvanus Y.] Boston Univ, Dept Mech Engn, Boston, MA 02215 USA.
[Walsh, Gary F.] USA, NSRDEC, Nanomat Sci Team, Natick, MA 01760 USA.
[Dal Negro, Luca] Div Mat Sci & Engn, Boston, MA 02215 USA.
RP Lee, SY (reprint author), Boston Univ, Dept Elect & Comp Engn, 8 St Marys St, Boston, MA 02215 USA.
EM dalnegro@bu.edu
FU AFOSR program "Deterministic Aperiodic Structures for On-chip
Nanophotonic and Nanoplasmonic Device Applications" [FA9550-10-1-0019];
U.S. Army NSRDEC PAO [U12-491]; SMART Scholarship Program; APIC
Corporation; PhotonIC Corporation
FX The work was supported by the AFOSR program "Deterministic Aperiodic
Structures for On-chip Nanophotonic and Nanoplasmonic Device
Applications" under Award FA9550-10-1-0019, the U.S. Army NSRDEC PAO #
U12-491, the SMART Scholarship Program, APIC Corporation and by PhotonIC
Corporation.
NR 60
TC 7
Z9 7
U1 2
U2 51
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1094-4087
J9 OPT EXPRESS
JI Opt. Express
PD FEB 25
PY 2013
VL 21
IS 4
BP 4945
EP 4957
DI 10.1364/OE.21.004945
PG 13
WC Optics
SC Optics
GA 104KU
UT WOS:000315992600100
PM 23482027
ER
PT J
AU Ngo-Duc, TT
Gacusan, J
Kobayashi, NP
Sanghadasa, M
Meyyappan, M
Oye, MM
AF Tam-Triet Ngo-Duc
Gacusan, Jovi
Kobayashi, Nobuhiko P.
Sanghadasa, Mohan
Meyyappan, M.
Oye, Michael M.
TI Controlled growth of vertical ZnO nanowires on copper substrate
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID MOLECULAR-BEAM EPITAXY; NANOSTRUCTURES; NANORODS; ARRAYS; MOCVD
AB We present an approach for diameter control of vertically aligned ZnO nanowires (NWs) grown directly on copper substrates. Vapor-solid growth was done at 550 degrees C with solid Zn precursor under Ar/O-2 flow, and the resulting nanowires with in situ-controllable diameters ranged between 50 to 500 nm. The nanowires were observed to elongate in tip growth and diameters were directly controlled by varying the oxygen concentration. Direct growth of vertical wires on metal substrates is expected to be useful to construct piezoelectric devices and applications involving sensors and detectors. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4793758]
C1 [Tam-Triet Ngo-Duc; Gacusan, Jovi; Meyyappan, M.; Oye, Michael M.] NASA, Ames Res Ctr, Ctr Nanotechnol, Moffett Field, CA 94035 USA.
[Tam-Triet Ngo-Duc; Gacusan, Jovi; Oye, Michael M.] NASA, Ames Res Ctr, ELORET Corp, Moffett Field, CA 94035 USA.
[Tam-Triet Ngo-Duc; Gacusan, Jovi; Kobayashi, Nobuhiko P.; Oye, Michael M.] NASA, Ames Res Ctr, UCSC NASA ARC Adv Studies Labs, Moffett Field, CA 94035 USA.
[Kobayashi, Nobuhiko P.; Oye, Michael M.] Univ Calif Santa Cruz, Dept Elect Engn, Santa Cruz, CA 95064 USA.
[Sanghadasa, Mohan] USA, Weap Sci Directorate, Aviat & Missile RDEC, RDECOM, Redstone Arsenal, AL 35898 USA.
RP Oye, MM (reprint author), NASA, Ames Res Ctr, Ctr Nanotechnol, Moffett Field, CA 94035 USA.
EM Michael.M.Oye@nasa.gov
RI Kobayashi, Nobuhiko/E-3834-2012
FU DARPA [W31P4Q-11-c-0230]; NASA [NNX09AQ44A]
FX This work was partially supported by DARPA contract W31P4Q-11-c-0230 to
ELORET Corp. A NASA grant NNX09AQ44A to University of California Santa
Cruz is acknowledged for instruments in the UCSC MACS Facility within
the UCSC/NASA-ARC ASL.
NR 23
TC 9
Z9 9
U1 1
U2 64
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0003-6951
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD FEB 25
PY 2013
VL 102
IS 8
AR 083105
DI 10.1063/1.4793758
PG 4
WC Physics, Applied
SC Physics
GA 099CN
UT WOS:000315597000066
ER
PT J
AU Kotan, H
Darling, KA
Saber, M
Koch, CC
Scattergood, RO
AF Kotan, Hasan
Darling, Kris A.
Saber, Mostafa
Koch, Carl C.
Scattergood, Ronald O.
TI Effect of zirconium on grain growth and mechanical properties of a
ball-milled nanocrystalline FeNi alloy
SO JOURNAL OF ALLOYS AND COMPOUNDS
LA English
DT Article
DE Nanocrystalline materials; Thermal stabilization; Grain growth;
Shear-punch test; Mechanical properties
ID VACANCY FORMATION ENERGIES; THERMAL-STABILITY; SOLUTE SEGREGATION; NI
ALLOYS; NANOSTRUCTURED MATERIALS; PRECIPITATE PARTICLES; DISLOCATION
LINE; BOUNDARY; HARDNESS; METALS
AB Grain growth of ball-milled pure Fe, Fe92Ni8, and Fe91Ni8Zr1 alloys has been studied using X-ray diffractometry (XRD), focused ion beam (FIB) microscopy and transmission electron microscopy (TEM). Mechanical properties with respect to compositional changes and annealing temperatures have been investigated using microhardness and shear punch tests. We found the rate of grain growth of the Fe91Ni8Zr1 alloy to be much less than that of pure Fe and the Fe92Ni8 alloy at elevated temperatures. The microstructure of the ternary Fe91Ni8Zr1 alloy remains nanoscale up to 700 degrees C where only a few grains grow abnormally whereas annealing of pure iron and the Fe92Ni8 alloy leads to extensive grain growth. The grain growth of the ternary alloy at high annealing temperatures is coupled with precipitation of Fe2Zr. A fine dispersion of precipitated second phase is found to promote the microstructural stability at high annealing temperatures and to increase the hardness and ultimate shear strength of ternary Fe91Ni8Zr1 alloy drastically when the grain size is above nanoscale. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Kotan, Hasan; Saber, Mostafa; Koch, Carl C.; Scattergood, Ronald O.] NC State Univ, Dept Mat Sci & Engn, Raleigh, NC 27606 USA.
[Darling, Kris A.] USA, Res Lab, Weap & Mat Res Directorate, RDRL WMM F, Aberdeen Proving Ground, MD 21005 USA.
RP Kotan, H (reprint author), NC State Univ, Dept Mat Sci & Engn, 911 Partners Way,Room 3078, Raleigh, NC 27606 USA.
EM hkotan@ncsu.edu
FU NSF-DMR [1005677]
FX The research reported in this paper was supported by NSF-DMR under grant
number 1005677.
NR 59
TC 11
Z9 11
U1 6
U2 74
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0925-8388
EI 1873-4669
J9 J ALLOY COMPD
JI J. Alloy. Compd.
PD FEB 25
PY 2013
VL 551
BP 621
EP 629
DI 10.1016/j.jallcom.2012.10.179
PG 9
WC Chemistry, Physical; Materials Science, Multidisciplinary; Metallurgy &
Metallurgical Engineering
SC Chemistry; Materials Science; Metallurgy & Metallurgical Engineering
GA 072EI
UT WOS:000313651600104
ER
PT J
AU Moreno, M
Bickersmith, S
Harlow, W
Hildebrandt, J
McKeon, SN
Silva-do-Nascimento, TF
Loaiza, JR
Ruiz, F
Lourenco-de-Oliveira, R
Sallum, MAM
Bergo, ES
Fritz, GN
Wilkerson, RC
Linton, YM
Juri, MJD
Rangel, Y
Povoa, MM
Gutierrez-Builes, LA
Correa, MM
Conn, JE
AF Moreno, Marta
Bickersmith, Sara
Harlow, Wesley
Hildebrandt, Jessica
McKeon, Sascha N.
Silva-do-Nascimento, Teresa Fernandes
Loaiza, Jose R.
Ruiz, Freddy
Lourenco-de-Oliveira, Ricardo
Sallum, Maria A. M.
Bergo, Eduardo S.
Fritz, Gary N.
Wilkerson, Richard C.
Linton, Yvonne M.
Dantur Juri, Maria J.
Rangel, Yadira
Povoa, Marinete M.
Gutierrez-Builes, Lina A.
Correa, Margarita M.
Conn, Jan E.
TI Phylogeography of the neotropical Anopheles triannulatus complex
(Diptera: Culicidae) supports deep structure and complex patterns
SO PARASITES & VECTORS
LA English
DT Article
DE Anopheles triannulatus s.s.; Anopheles halophylus; Anopheles
triannulatus C; phylogeography; COI gene; White gene; ITS2
ID MITOCHONDRIAL-DNA; MALARIA VECTOR; PHYLOGENETIC-RELATIONSHIPS;
POPULATION-STRUCTURE; GENETIC-STRUCTURE; BRAZILIAN AMAZON; MOLECULAR
PHYLOGENETICS; SPECIES DIPTERA; CENTRAL-AMERICA; SOUTH-AMERICA
AB Background: The molecular phylogenetic relationships and population structure of the species of the Anopheles triannulatus complex: Anopheles triannulatus s.s., Anopheles halophylus and the putative species Anopheles triannulatus C were investigated.
Methods: The mitochondrial COI gene, the nuclear white gene and rDNA ITS2 of samples that include the known geographic distribution of these taxa were analyzed. Phylogenetic analyses were performed using Bayesian inference, Maximum parsimony and Maximum likelihood approaches.
Results: Each data set analyzed separately yielded a different topology but none provided evidence for the separation of An. halophylus and An. triannulatus C, consistent with the hypothesis that the two are undergoing incipient speciation. The phylogenetic analyses of the white gene found three main clades, whereas the statistical parsimony network detected only a single metapopulation of Anopheles triannulatus s. l. Seven COI lineages were detected by phylogenetic and network analysis. In contrast, the network, but not the phylogenetic analyses, strongly supported three ITS2 groups. Combined data analyses provided the best resolution of the trees, with two major clades, Amazonian (clade I) and trans-Andean + Amazon Delta (clade II). Clade I consists of multiple subclades: An. halophylus + An. triannulatus C; trans-Andean Venezuela; central Amazonia + central Bolivia; Atlantic coastal lowland; and Amazon delta. Clade II includes three subclades: Panama; cis-Andean Colombia; and cis-Venezuela. The Amazon delta specimens are in both clades, likely indicating local sympatry. Spatial and molecular variance analyses detected nine groups, corroborating some of subclades obtained in the combined data analysis.
Conclusion: Combination of the three molecular markers provided the best resolution for differentiation within An. triannulatus s. s. and An. halophylus and C. The latest two species seem to be very closely related and the analyses performed were not conclusive regarding species differentiation. Further studies including new molecular markers would be desirable to solve this species status question. Besides, results of the study indicate a trans-Andean origin for An. triannulatus s. l. The potential implications for malaria epidemiology remain to be investigated.
C1 [Moreno, Marta; Bickersmith, Sara; Harlow, Wesley; Hildebrandt, Jessica; McKeon, Sascha N.; Conn, Jan E.] New York State Dept Hlth, Wadsworth Ctr, Griffin Lab, Albany, NY USA.
[McKeon, Sascha N.; Conn, Jan E.] SUNY Albany, Sch Publ Hlth, Dept Biomed Sci, Albany, NY USA.
[Silva-do-Nascimento, Teresa Fernandes; Lourenco-de-Oliveira, Ricardo] Inst Oswaldo Cruz Fiocruz, Dept Entomol, Rio De Janeiro, Brazil.
[Loaiza, Jose R.] Inst Invest Cient & Serv Alta Tecnol, Clayton, Panama.
[Ruiz, Freddy; Wilkerson, Richard C.; Linton, Yvonne M.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD USA.
[Sallum, Maria A. M.] Univ Sao Paulo, Fac Saude Publ, Dept Epidemiol, BR-01255 Sao Paulo, Brazil.
[Bergo, Eduardo S.] SUCEN, Superintendencia Controle Endemias, Sao Paulo, Brazil.
[Fritz, Gary N.] Eastern Illinois Univ, Dept Biol Sci, Charleston, IL 61920 USA.
[Dantur Juri, Maria J.] Univ Nacl Tucuman, Inst Super Entomol Dr Abraham Willink, Fac Ciencias Nat & Inst Miguel Lillo, San Miguel De Tucuman, Argentina.
[Rangel, Yadira] Cent Univ Venezuela, Lab Biol Vectores, Inst Zool & Ecol Trop, Caracas, Venezuela.
[Povoa, Marinete M.] Inst Evandro Chagas, Seccao Parasitol, Belem, Para, Brazil.
[Gutierrez-Builes, Lina A.; Correa, Margarita M.] Univ Antioquia, Escuela Microbiol, Grp Microbiol Mol, Medellin, Colombia.
RP Moreno, M (reprint author), Univ Calif San Diego, Sch Med, Div Infect Dis, George Palade Labs, 9500 Gilman Dr,MC 0741, La Jolla, CA 92093 USA.
EM mmorenoleirana@ucsd.edu
RI Sallum, Maria/B-8537-2012;
OI Conn, Jan/0000-0002-5301-7020; BERGO, EDUARDO/0000-0003-4928-0368;
Gutierrez Builes, Lina Andrea/0000-0002-5336-6984
FU NIH [AI ROI 54139-02]; PAPES IV Fiocruz-CNPq; Fundacao de Amparo a
Pesquisa do Estado de Sao Paulo, FAPESP [2011/20397-7]; CNPq
[301666/2011-3]
FX This project has been financially supported by NIH grant AI ROI 54139-02
to JE Conn, PAPES IV Fiocruz-CNPq to RLO, and from the Fundacao de
Amparo a Pesquisa do Estado de Sao Paulo, FAPESP (Grant 2011/20397-7 to
MAMS), CNPq (BPP no. 301666/2011-3 to MAMS).
NR 90
TC 7
Z9 7
U1 0
U2 18
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1756-3305
J9 PARASITE VECTOR
JI Parasites Vectors
PD FEB 22
PY 2013
VL 6
AR 47
DI 10.1186/1756-3305-6-47
PG 17
WC Parasitology
SC Parasitology
GA 114TN
UT WOS:000316765600001
PM 23433428
ER
PT J
AU Moncunill, G
Mayor, A
Jimenez, A
Nhabomba, A
Puyol, L
Manaca, MN
Barrios, D
Cistero, P
Guinovart, C
Aguilar, R
Bardaji, A
Pinazo, MJ
Angov, E
Dutta, S
Chitnis, CE
Munoz, J
Gascon, J
Dobano, C
AF Moncunill, Gemma
Mayor, Alfredo
Jimenez, Alfons
Nhabomba, Augusto
Puyol, Laura
Manaca, Maria N.
Barrios, Diana
Cistero, Pau
Guinovart, Caterina
Aguilar, Ruth
Bardaji, Azucena
Pinazo, Maria-Jesus
Angov, Evelina
Dutta, Sheetij
Chitnis, Chetan E.
Munoz, Jose
Gascon, Joaquim
Dobano, Carlota
TI Cytokine and Antibody Responses to Plasmodium falciparum in Naive
Individuals during a First Malaria Episode: Effect of Age and Malaria
Exposure
SO PLOS ONE
LA English
DT Article
ID ERYTHROCYTE-MEMBRANE PROTEIN-1; VARIANT SURFACE-ANTIGENS; INFECTED
ERYTHROCYTES; MOZAMBICAN CHILDREN; ACQUIRED-IMMUNITY; CLINICAL MALARIA;
PREGNANT-WOMEN; BLOOD-STAGE; PROTECTION; INTERLEUKIN-12
AB Age- and exposure-dependent immune responses during a malaria episode may be key to understanding the role of these factors in the acquisition of immunity to malaria. Plasma/serum samples collected from naive Mozambican children (n = 48), European adults (naive travelers, n = 22; expatriates with few prior malaria exposures, n = 15) and Mozambican adults with long-life malaria exposure (n = 99) during and after a malaria episode were analyzed for IgG against merozoite proteins by Luminex and against infected erythrocytes by flow cytometry. Cytokines and chemokines were analyzed in plasmas/sera by suspension array technology. No differences were detected between children and adults with a primary infection, with the exception of higher IgG levels against 3D7 MSP-1(42) (P = 0.030) and a P. falciparum isolate (P = 0.002), as well as higher IL-12 (P = 0.020) in children compared to other groups. Compared to malaria-exposed adults, children, travelers and expatriates had higher concentrations of IFN-gamma (P <= 0.0090), IL-2 (P <= 0.0379) and IL-8 (P <= 0.0233). Children also had higher IL-12 (P = 0.0001), IL-4 (P = 0.003), IL-1 beta (P = 0.024) and TNF (P = 0.006) levels compared to malaria-exposed adults. Although IL-12 was elevated in children, overall the data do not support a role of age in immune responses to a first malaria episode. A T(H)1/pro-inflammatory response was the hallmark of non-immune subjects.
C1 [Moncunill, Gemma; Mayor, Alfredo; Jimenez, Alfons; Puyol, Laura; Barrios, Diana; Cistero, Pau; Guinovart, Caterina; Aguilar, Ruth; Bardaji, Azucena; Pinazo, Maria-Jesus; Munoz, Jose; Gascon, Joaquim; Dobano, Carlota] Univ Barcelona, Barcelona Ctr Int Hlth Res, Hosp Clin, CRESIB, Barcelona, Spain.
[Mayor, Alfredo; Nhabomba, Augusto; Manaca, Maria N.; Guinovart, Caterina; Aguilar, Ruth; Dobano, Carlota] Ctr Invest Saude Manhica, Maputo, Mozambique.
[Angov, Evelina; Dutta, Sheetij] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Chitnis, Chetan E.] Int Ctr Genet Engn & Biotechnol, New Delhi, India.
RP Moncunill, G (reprint author), Univ Barcelona, Barcelona Ctr Int Hlth Res, Hosp Clin, CRESIB, Barcelona, Spain.
EM gemma.moncunil@cresib.cat
RI Gascon, Joaquim/M-3598-2015; Dobano, Carlota/N-4119-2014;
OI Gascon, Joaquim/0000-0002-5045-1585; Dobano,
Carlota/0000-0002-6751-4060; Moncunill, Gemma/0000-0001-5105-9836
FU Ministerio de Ciencia e Innovacion [SAF2008-00743, SAF2005-25642-E,
RYC-2008-02631]; Instituto de Salud Carlos III [PI050275, A107190024,
PS0901113, CD10/00156, CP-4/00220, CM04/00028]; EU FP6
[LSHP-CT-2005-18902]; Fundacion Ramon Areces
FX The study received financial support from the Ministerio de Ciencia e
Innovacion (SAF2008-00743, SAF2005-25642-E, salary support
RYC-2008-02631 to CD); the Instituto de Salud Carlos III (PI050275,
A107190024, PS0901113, salary support CD10/00156 to GM, CP-4/00220 to
AM, and CM04/00028 to CG), the EU FP6 (LSHP-CT-2005-18902), and the
Fundacion Ramon Areces. The Centro de Investigacao em Saude de Manhica
receives core support from the Spanish Agency for International
Cooperation and Development (AECID). The funders had no role in study
design, data collection and analysis, decision to publish, or
preparation of the manuscript.
NR 57
TC 8
Z9 9
U1 2
U2 17
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 21
PY 2013
VL 8
IS 2
AR e55756
DI 10.1371/journal.pone.0055756
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 093IT
UT WOS:000315186000008
PM 23437061
ER
PT J
AU Kraczek, B
Chung, PW
AF Kraczek, B.
Chung, P. W.
TI Investigation of direct and indirect phonon-mediated bond excitation in
alpha-RDX
SO JOURNAL OF CHEMICAL PHYSICS
LA English
DT Article
ID ENERGY-TRANSFER RATES; WAVE INDUCED DECOMPOSITION; HOT-SPOT FORMATION;
MOLECULAR-CRYSTALS; IMPACT SENSITIVITIES; FORCE-FIELD; EXPLOSIVES;
DYNAMICS; CHEMISTRY; SOLIDS
AB We evaluate whether lattice or internal phonons dominate the thermal excitation of the N-N bonds in alpha-cyclotrimethylene trinitramine (alpha-RDX) by computing the fractional contributions of phonon modes to the excitation of all atomic interactions. We derive a method to compute these contributions, which we call mode energy fractions, from the phonon eigenvectors and a splitting of the dynamical matrix. This enables identification of phonon modes that most strongly excite the N-N bonds that play a key role in molecular decomposition of alpha-RDX. Correlating these fractions with the mode populations and contributions to the specific heat and thermal conductivity, we analyze how thermal energy is distributed by phonons following a passing shock. Contrary to the common explanation that thermal energy is transferred to the N-N bonds indirectly, by internal phonons, we find that lattice phonons dominate this thermal energy transfer, implying that energy flow follows a direct route. We also comment on implications of these results for non-shock decomposition of alpha-RDX. [http://dx.doi.org/10.1063/1.4790637]
C1 [Kraczek, B.; Chung, P. W.] USA, Computat & Informat Sci Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Kraczek, B (reprint author), USA, Computat & Informat Sci Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM brent.kraczek@us.army.mil; peter.w.chung@us.army.mil
FU Department of the Army Program [0601102A H44 06]; Department of
Defense/Army High Performance Computing Modernization Program for
Multi-scale Reactive Modeling of Insensitive Munitions Software
Applications Institute; Oak Ridge Affiliated Universities (ORAU) in
Maryland .U.S. [W911QX-04-C-0129]
FX This work was supported in part by the Department of the Army Program
Element 0601102A H44 06 for Defense Research Sciences, the Department of
Defense/Army High Performance Computing Modernization Program for
Multi-scale Reactive Modeling of Insensitive Munitions Software
Applications Institute, and Oak Ridge Affiliated Universities (ORAU) in
Maryland under the Contract No. W911QX-04-C-0129 at the U.S. Army
Research Laboratory. The authors wish to thank Jennifer Ciezak-Jenkins
for helpful discussions.
NR 49
TC 7
Z9 7
U1 1
U2 14
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0021-9606
EI 1089-7690
J9 J CHEM PHYS
JI J. Chem. Phys.
PD FEB 21
PY 2013
VL 138
IS 7
AR 074505
DI 10.1063/1.4790637
PG 10
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA 094LE
UT WOS:000315263500037
PM 23445022
ER
PT J
AU Wu, DR
Lance, BJ
Parsons, TD
AF Wu, Dongrui
Lance, Brent J.
Parsons, Thomas D.
TI Collaborative Filtering for Brain-Computer Interaction Using Transfer
Learning and Active Class Selection
SO PLOS ONE
LA English
DT Article
ID PERFORMANCE ASSESSMENT TEST; VIRTUAL-REALITY; INTERFACES
AB Brain-computer interaction (BCI) and physiological computing are terms that refer to using processed neural or physiological signals to influence human interaction with computers, environment, and each other. A major challenge in developing these systems arises from the large individual differences typically seen in the neural/physiological responses. As a result, many researchers use individually-trained recognition algorithms to process this data. In order to minimize time, cost, and barriers to use, there is a need to minimize the amount of individual training data required, or equivalently, to increase the recognition accuracy without increasing the number of user-specific training samples. One promising method for achieving this is collaborative filtering, which combines training data from the individual subject with additional training data from other, similar subjects. This paper describes a successful application of a collaborative filtering approach intended for a BCI system. This approach is based on transfer learning (TL), active class selection (ACS), and a mean squared difference user-similarity heuristic. The resulting BCI system uses neural and physiological signals for automatic task difficulty recognition. TL improves the learning performance by combining a small number of user-specific training samples with a large number of auxiliary training samples from other similar subjects. ACS optimally selects the classes to generate user-specific training samples. Experimental results on 18 subjects, using both k nearest neighbors and support vector machine classifiers, demonstrate that the proposed approach can significantly reduce the number of user-specific training data samples. This collaborative filtering approach will also be generalizable to handling individual differences in many other applications that involve human neural or physiological data, such as affective computing.
C1 [Wu, Dongrui] GE Global Res, Machine Learning Lab, Niskayuna, NY USA.
[Lance, Brent J.] USA, Res Lab, Aberdeen, MD USA.
[Parsons, Thomas D.] Univ N Texas, Dept Psychol, Denton, TX 76203 USA.
RP Wu, DR (reprint author), GE Global Res, Machine Learning Lab, Niskayuna, NY USA.
EM drwu09@gmail.com
NR 65
TC 9
Z9 9
U1 0
U2 19
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 21
PY 2013
VL 8
IS 2
AR e56624
DI 10.1371/journal.pone.0056624
PG 18
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 093IT
UT WOS:000315186000035
PM 23437188
ER
PT J
AU Ramakrishnan, S
Rajaraman, S
Laxminarayan, S
Wesensten, NJ
Kamimori, GH
Balkin, TJ
Reifman, J
AF Ramakrishnan, Sridhar
Rajaraman, Srinivasan
Laxminarayan, Srinivas
Wesensten, Nancy J.
Kamimori, Gary H.
Balkin, Thomas J.
Reifman, Jaques
TI A biomathematical model of the restoring effects of caffeine on
cognitive performance during sleep deprivation
SO JOURNAL OF THEORETICAL BIOLOGY
LA English
DT Article
DE Caffeine model; Sleep loss; PVT; Individualized modeling;
Pharmacokinetic-pharmacodynamic model
ID NORMAL HEALTHY-VOLUNTEERS; PROLONGED WAKEFULNESS; DEPRIVED INDIVIDUALS;
2-PROCESS MODEL; CHEWING GUM; FATIGUE; PLASMA; PHARMACOKINETICS;
VIGILANCE; COUNTERMEASURES
AB Rationale: While caffeine is widely used as a countermeasure to sleep loss, mathematical models are lacking.
Objective: Develop a biomathematical model for the performance-restoring effects of caffeine in sleep-deprived subjects.
Methods: We hypothesized that caffeine has a multiplicative effect on performance during sleep loss. Accordingly, we first used a phenomenological two-process model of sleep regulation to estimate performance in the absence of caffeine, and then multiplied a caffeine-effect factor, which relates the pharmacokinetic-pharmacodynamic effects through the Hill equation, to estimate the performance-restoring effects of caffeine.
Results: We validated the model on psychomotor vigilance test data from two studies involving 12 subjects each: (1) single caffeine dose of 600 mg after 64.5 h of wakefulness and (2) repeated doses of 200 mg after 20, 22, and 24 h of wakefulness. Individualized caffeine models produced overall errors that were 19% and 42% lower than their population-average counterparts for the two studies. Had we not accounted for the effects of caffeine, the individualized model errors would have been 117% and 201% larger, respectively.
Conclusions: The presented model captured the performance-enhancing effects of caffeine for most subjects in the single- and repeated-dose studies, suggesting that the proposed multiplicative factor is a feasible solution. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Ramakrishnan, Sridhar; Rajaraman, Srinivasan; Laxminarayan, Srinivas; Reifman, Jaques] USA, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, DoD Biotechnol High Performance Comp Software App, Frederick, MD 21702 USA.
[Wesensten, Nancy J.; Kamimori, Gary H.; Balkin, Thomas J.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD 20910 USA.
RP Reifman, J (reprint author), USA, Med Res & Mat Command, ATTN MCMR TT,Telemed & Adv Technol Res Ctr, DoD Biotechnol High Performance Comp Software App, 504 Scott St, Ft Detrick, MD 21702 USA.
EM jaques.reifman@us.army.mil
FU Military Operational Medicine Research Area Directorate of the U.S. Army
Medical Research and Materiel Command, Ft. Detrick, MD; U.S. Department
of Defense Medical Research and Development Program [DMRDP_13200]
FX This work was sponsored by the Military Operational Medicine Research
Area Directorate of the U.S. Army Medical Research and Materiel Command,
Ft. Detrick, MD, and by the U.S. Department of Defense Medical Research
and Development Program (Grant No. DMRDP_13200).
NR 46
TC 4
Z9 4
U1 0
U2 31
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0022-5193
J9 J THEOR BIOL
JI J. Theor. Biol.
PD FEB 21
PY 2013
VL 319
BP 23
EP 33
DI 10.1016/j.jtbi.2012.11.015
PG 11
WC Biology; Mathematical & Computational Biology
SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational
Biology
GA 084QA
UT WOS:000314553000003
PM 23182694
ER
PT J
AU Zou, XT
Wu, N
Tian, Y
Zhang, Y
Fitek, J
Maffeo, M
Niezrecki, C
Chen, J
Wang, XW
AF Zou, Xiaotian
Wu, Nan
Tian, Ye
Zhang, Yang
Fitek, John
Maffeo, Michael
Niezrecki, Christopher
Chen, Julie
Wang, Xingwei
TI Ultrafast Fabry-Perot fiber-optic pressure sensors for multimedia blast
event measurements
SO APPLIED OPTICS
LA English
DT Article
ID SHOCK-WAVE; INJURIES
AB A shock wave (SW) is characterized as a large pressure fluctuation that typically lasts only a few milliseconds. On the battlefield, SWs pose a serious threat to soldiers who are exposed to explosions, which may lead to blast-induced traumatic brain injuries. SWs can also be used beneficially and have been applied to a variety of medical treatments due to their unique interaction with tissues and cells. Consequently, it is important to have sensors that can quantify SW dynamics in order to better understand the physical interaction between body tissue and the incident acoustic wave. In this paper, the ultrafast fiber-optic sensor based on the Fabry-Perot interferometric principle was designed and four such sensors were fabricated to quantify a blast event within different media, simultaneously. The compact design of the fiber-optic sensor allows for a high degree of spatial resolution when capturing the wavefront of the traveling SW. Several blast event experiments were conducted within different media (e. g., air, rubber membrane, and water) to evaluate the sensor's performance. This research revealed valuable knowledge for further study of SW behavior and SW-related applications. (C) 2013 Optical Society of America
C1 [Zou, Xiaotian; Wang, Xingwei] Univ Massachusetts Lowell, Dept Biomed Engn & Biotechnol, Lowell, MA 01854 USA.
[Wu, Nan; Tian, Ye; Zhang, Yang; Wang, Xingwei] Univ Massachusetts Lowell, Dept Elect & Comp Engn, Lowell, MA 01854 USA.
[Fitek, John; Maffeo, Michael] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA.
[Niezrecki, Christopher; Chen, Julie] Univ Massachusetts Lowell, Dept Mech Engn, Lowell, MA 01854 USA.
RP Wang, XW (reprint author), Univ Massachusetts Lowell, Dept Biomed Engn & Biotechnol, 1 Univ Ave, Lowell, MA 01854 USA.
EM xingwei_wang@uml.edu
RI Tian, Ye/A-1090-2014; Zou, Xiaotian/J-8657-2013
OI Tian, Ye/0000-0002-0785-1145;
FU Army Research Laboratory [W911NF-07-2-0081]
FX The authors are grateful for the collaboration with Natick Soldier
Research, Development and Engineering Center for sharing the shock tube
and the reference pressure sensors. The authors also appreciate the Army
Research Laboratory for sponsoring this work (Nanomanufacturing of
Multifunctional Sensors Award Number W911NF-07-2-0081).
NR 20
TC 5
Z9 5
U1 2
U2 30
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1559-128X
EI 2155-3165
J9 APPL OPTICS
JI Appl. Optics
PD FEB 20
PY 2013
VL 52
IS 6
BP 1248
EP 1254
DI 10.1364/AO.52.001248
PG 7
WC Optics
SC Optics
GA 094TM
UT WOS:000315286700018
PM 23434996
ER
PT J
AU Barrett, A
Ndou, T
Hughey, CA
Straut, C
Howell, A
Dai, ZF
Kaletunc, G
AF Barrett, Ann
Ndou, Tshinanne
Hughey, Christine A.
Straut, Christine
Howell, Amy
Dai, Zifei
Kaletunc, Gonul
TI Inhibition of alpha-Amylase and Glucoamylase by Tannins Extracted from
Cocoa, Pomegranates, Cranberries, and Grapes
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE condensed tannins; proanthocyanidins; alpha-amylase inhibition;
glucoamylase inhibition; pomegranate; cocoa; cranberry; grape; LC/MS;
NMR; DSC
ID FIMBRIATED ESCHERICHIA-COLI; MASS-SPECTROMETRY; A-TYPE; POLYMERIC
PROCYANIDINS; PLASMA-GLUCOSE; PROANTHOCYANIDINS; POLYPHENOLS; ADHERENCE;
JUICE; BLUEBERRY
AB Proanthocyanidins and ellagitannins, referred to as "tannins", exist in many plant sources. These compounds interact with proteins due to their numerous hydroxyl groups, which are suitable for hydrophobic associations. It was hypothesized that tannins could bind to the digestive enzymes a-amylase and glucoamylase, thereby inhibiting starch hydrolysis. Slowed starch digestion can theoretically increase satiety by modulating glucose "spiking" and depletion that occurs after carbohydrate-rich meals. Tannins were isolated from extracts of pomegranate, cranberry, grape, and cocoa and these isolates tested for effectiveness to inhibit the activity of a-amylase and glucoamylase in vitro. The compositions of the isolates were confirmed by NMR and LC/MS analysis, and tannin protein interactions were investigated using relevant enzyme assays and differential scanning calorimetry (DSC). The results demonstrated inhibition of each enzyme by each tannin, but with variation in magnitude. In general, larger and more complex tannins, such as those in pomegranate and cranberry, more effectively inhibited the enzymes than did less polyrnerized cocoa tannins. Interaction of the tannins with the enzymes was confirmed through calorimetric measurements of changes in enzyme thermal stability.
C1 [Barrett, Ann; Ndou, Tshinanne] USA, PORT Combat Feeding Directorate, NSRDEC, Natick, MA 01760 USA.
[Hughey, Christine A.] James Madison Univ, Dept Chem & Biochem, Harrisonburg, VA 22807 USA.
[Hughey, Christine A.] USA, Batelle Warfighter Sci Technol & Res Directorate, NSRDEC, Natick, MA 01760 USA.
[Howell, Amy] Rutgers State Univ, Marucci Ctr Blueberry Cranberry Res, Chatsworth, NJ 08019 USA.
[Dai, Zifei; Kaletunc, Gonul] Ohio State Univ, Dept Food Agr & Biol Engn, Columbus, OH 43210 USA.
RP Barrett, A (reprint author), USA, PORT Combat Feeding Directorate, NSRDEC, Natick, MA 01760 USA.
EM ann.h.barrett.civ@mail.mil
FU National Science Foundation [NSF MRI CHE-0922935, CHE-1046630]
FX This material is partially based upon work supported by the National
Science Foundation under Grants NSF MRI CHE-0922935 and CHE-1046630.
NR 44
TC 26
Z9 27
U1 9
U2 95
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD FEB 20
PY 2013
VL 61
IS 7
BP 1477
EP 1486
DI 10.1021/jf304876g
PG 10
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
Technology
SC Agriculture; Chemistry; Food Science & Technology
GA 095HV
UT WOS:000315326200009
PM 23289516
ER
PT J
AU Manocchi, AK
Baker, DR
Pendley, SS
Nguyen, K
Hurley, MM
Bruce, BD
Sumner, JJ
Lundgren, CA
AF Manocchi, Amy K.
Baker, David R.
Pendley, Scott S.
Khoa Nguyen
Hurley, Margaret M.
Bruce, Barry D.
Sumner, James J.
Lundgren, Cynthia A.
TI Photocurrent Generation from Surface Assembled Photosystem I on
Alkanethiol Modified Electrodes
SO LANGMUIR
LA English
DT Article
ID PHOTOSYNTHETIC REACTION CENTERS; HARVESTING CORE COMPLEXES;
REACTION-CENTER PROTEIN; ANGSTROM RESOLUTION; MONOLAYERS; GOLD;
ELECTROCHEMISTRY; FABRICATION; BACTERIA; GLUCOSE
AB Photosystem I (PSI) is a key component of oxygenic photosynthetic electron transport because of its light-induced electron transfer to the soluble electron acceptor ferredoxin. This work demonstrates the incorporation of surface assembled cyanobacterial trimeric PSI complexes into a biohybrid system for light-driven current generation. Specifically, this work demonstrates the improved assembly of PSI via electrophoretic deposition, with controllable surface assembled PSI density, on different self-assembled alkanethiol monolayers. Using artificial electron donors and acceptors (Os(bpy)(2)Cl-2 and methyl viologen) we demonstrate photocurrent generation from a single PSI layer, which remains photoactive for at least three hours of intermittent illumination. Photoelectrochemical comparison of the biohybrid systems assembled from different alkanethiols (hexanethiol, aminohexanethiol, mercaptohexanol, and mercaptohexanoic acid) reveals that the PSI generated photocurrent is enhanced by almost 5 times on negatively charged SAM surfaces as compared to positively charged surfaces. These results are discussed in light of how PSI is oriented upon electrodeposition on a SAM.
C1 [Manocchi, Amy K.; Baker, David R.; Sumner, James J.; Lundgren, Cynthia A.] USA, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA.
[Pendley, Scott S.; Hurley, Margaret M.] USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Khoa Nguyen; Bruce, Barry D.] Univ Tennessee, Biochem Cellular & Mol Biol Dept, Knoxville, TN 37996 USA.
[Bruce, Barry D.] Univ Tennessee, Chem & Biomol Engn Dept, Knoxville, TN 37996 USA.
RP Lundgren, CA (reprint author), USA, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA.
EM cynthia.a.lundgren2.civ@mail.mil
FU U.S. Department of the Army; U.S. Army Materiel Command; U.S. Army
Research Laboratory; NSF [EPS-1004083]
FX Financial support from the U.S. Department of the Army and U.S. Army
Materiel Command are gratefully acknowledged. Research was supported, in
part, by a contractual appointment to the U.S. Army Research Laboratory
Postdoctoral Fellowship Program administered by the Oak Ridge Associated
Universities (A.(M., D.R.B., S.S.P.). B.D.B. was partially supported by
a NSF grant, EPS-1004083.
NR 36
TC 25
Z9 25
U1 2
U2 89
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0743-7463
J9 LANGMUIR
JI Langmuir
PD FEB 19
PY 2013
VL 29
IS 7
BP 2412
EP 2419
DI 10.1021/la304477u
PG 8
WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science,
Multidisciplinary
SC Chemistry; Materials Science
GA 121RA
UT WOS:000317260700037
PM 23379304
ER
PT J
AU Boscolo, S
Pelin, M
De Bortoli, M
Fontanive, G
Barreras, A
Berti, F
Sosa, S
Chaloin, O
Bianco, A
Yasumoto, T
Prato, M
Poli, M
Tubaro, A
AF Boscolo, S.
Pelin, M.
De Bortoli, M.
Fontanive, G.
Barreras, A.
Berti, F.
Sosa, S.
Chaloin, O.
Bianco, A.
Yasumoto, T.
Prato, M.
Poli, M.
Tubaro, A.
TI Sandwich ELISA Assay for the Quantitation of Palytoxin and Its Analogs
in Natural Samples
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID OF-THE-ART; CROSS-LINKING; ENZYME-IMMUNOASSAY; PUTATIVE PALYTOXIN;
OSTREOPSIS-OVATA; ANTIBODIES; OVATOXINS; STATE; IDENTIFICATION;
SPECTROMETRY
AB Palytoxins are potent marine biotoxins that have recently become endemic to the Mediterranean Sea, and are becoming more frequently associated with seafood. Due to their high toxicity, suitable methods to quantify palytoxins are needed. Thus, we developed an indirect sandwich ELISA for palytoxin and 42-hydroxy-palytoxin. An intra-laboratory study demonstrated sensitivity (limit of detection, LOD = 1.1 ng/mL; limit of quantitation, LOQ = 2.2 ng/mL), accuracy (bias of 2.1%), repeatability (RSDr = 6% and 9% for intra- and interassay variability, respectively) and specificity: other common marine toxins (okadaic acid, domoic acid, saxitoxin, brevetoxin-3, and yessotoxin) do not cross-react in this assay. It performed well in three different matrices: observed LOQs were 11.0, 9.6, and 2.4 ng/mL for mussel extracts, algal net samples and seawater, respectively, with good accuracy and precision. The LOQ in seafood is 11 mu g palytoxin/kg mussel meat, lower than that of the most common detection technique, LC-MS/MS.
C1 [Boscolo, S.; Tubaro, A.] Univ Trieste, Dept Life Sci, I-34127 Trieste, Italy.
[Pelin, M.; De Bortoli, M.; Barreras, A.; Sosa, S.] Univ Trieste, Dept Life Sci, I-34127 Trieste, Italy.
[Fontanive, G.; Berti, F.] Univ Trieste, Dept Chem & Pharmaceut Sci, I-34127 Trieste, Italy.
[Chaloin, O.; Bianco, A.] CNRS, Inst Biol Mol & Cellulaire, Lab Immunol & Chim Therapeut, F-67000 Strasbourg, France.
[Yasumoto, T.] Tama Lab, Japan Food Res Labs, Tama, Tokyo 2060025, Japan.
[Prato, M.] Univ Trieste, Dept Chem & Pharmaceut Sci, I-34127 Trieste, Italy.
[Poli, M.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21701 USA.
RP Tubaro, A (reprint author), Univ Trieste, Dept Life Sci, Via L Giorgieri 10, I-34127 Trieste, Italy.
EM tubaro@units.it
RI Prato, Maurizio/G-7067-2012
OI Prato, Maurizio/0000-0002-8869-8612
FU Regione Autonoma Friuli-Venezia Giulia, Direzione Risorse Rurali,
Agroalimentari e Forestali
FX This work was supported by Regione Autonoma Friuli-Venezia Giulia,
Direzione Risorse Rurali, Agroalimentari e Forestali. M.P. is grateful
to the Italian Ministry of Education (cofin Prot. 20085M27SS). A.B and
O.C. are grateful to the Centre National de la Recherche Scientifique
(France). WE are grateful to Prof. G. Honsell (University of Udine,
Italy) for providing and characterization of algal samples and to Dr. E.
D'Orlando (University of Trieste, Italy) for her assistance.
NR 42
TC 12
Z9 12
U1 1
U2 59
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD FEB 19
PY 2013
VL 47
IS 4
BP 2034
EP 2042
DI 10.1021/es304222t
PG 9
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 095IA
UT WOS:000315326700032
PM 23339823
ER
PT J
AU Hairston, WD
Letowski, TR
McDowell, K
AF Hairston, W. David
Letowski, Tomasz R.
McDowell, Kaleb
TI Task-Related Suppression of the Brainstem Frequency following Response
SO PLOS ONE
LA English
DT Article
ID AUDITORY SELECTIVE ATTENTION; EVOKED-POTENTIALS; INFERIOR COLLICULUS;
MUSICAL EXPERIENCE; VISUAL-CORTEX; SPEECH; MODULATION; PITCH; STIMULI;
DEACTIVATION
AB Recent evidence has shown top-down modulation of the brainstem frequency following response (FFR), generally in the form of signal enhancement from concurrent stimuli or from switching between attention-demanding task stimuli. However, it is also possible that the opposite may be true - the addition of a task, instead of a resting, passive state may suppress the FFR. Here we examined the influence of a subsequent task, and the relevance of the task modality, on signal clarity within the FFR. Participants performed visual and auditory discrimination tasks in the presence of an irrelevant background sound, as well as a baseline consisting of the same background stimuli in the absence of a task. FFR pitch strength and amplitude of the primary frequency response were assessed within non-task stimulus periods in order to examine influences due solely to general cognitive state, independent of stimulus-driven effects. Results show decreased signal clarity with the addition of a task, especially within the auditory modality. We additionally found consistent relationships between the extent of this suppressive effect and perceptual measures such as response time and proclivity towards one sensory modality. Together these results suggest that the current focus of attention can have a global, top-down effect on the quality of encoding early in the auditory pathway.
C1 [Hairston, W. David; Letowski, Tomasz R.; McDowell, Kaleb] USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA.
RP Hairston, WD (reprint author), USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA.
EM William.d.hairston4.civ@mail.mil
OI Hairston, W. David/0000-0003-4432-8430
NR 60
TC 15
Z9 15
U1 2
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 18
PY 2013
VL 8
IS 2
AR e55215
DI 10.1371/journal.pone.0055215
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 092YP
UT WOS:000315159200008
PM 23441150
ER
PT J
AU Shoemaker, CJ
Schornberg, KL
Delos, SE
Scully, C
Pajouhesh, H
Olinger, GG
Johansen, LM
White, JM
AF Shoemaker, Charles J.
Schornberg, Kathryn L.
Delos, Sue E.
Scully, Corinne
Pajouhesh, Hassan
Olinger, Gene G.
Johansen, Lisa M.
White, Judith M.
TI Multiple Cationic Amphiphiles Induce a Niemann-Pick C Phenotype and
Inhibit Ebola Virus Entry and Infection
SO PLOS ONE
LA English
DT Article
ID ATOMIC PHYSICOCHEMICAL PARAMETERS; SMALL-MOLECULE INHIBITORS; ACID
SPHINGOMYELINASE; QUANTITATIVE STRUCTURE; CATHEPSIN-L; LOG-P;
GLYCOPROTEIN; PROTEIN; CELLS; CHOLESTEROL
AB Ebola virus (EBOV) is an enveloped RNA virus that causes hemorrhagic fever in humans and non-human primates. Infection requires internalization from the cell surface and trafficking to a late endocytic compartment, where viral fusion occurs, providing a conduit for the viral genome to enter the cytoplasm and initiate replication. In a concurrent study, we identified clomiphene as a potent inhibitor of EBOV entry. Here, we screened eleven inhibitors that target the same biosynthetic pathway as clomiphene. From this screen we identified six compounds, including U18666A, that block EBOV infection (IC50 1.6 to 8.0 mu M) at a late stage of entry. Intriguingly, all six are cationic amphiphiles that share additional chemical features. U18666A induces phenotypes, including cholesterol accumulation in endosomes, associated with defects in Niemann-Pick C1 protein (NPC1), a late endosomal and lysosomal protein required for EBOV entry. We tested and found that all six EBOV entry inhibitors from our screen induced cholesterol accumulation. We further showed that higher concentrations of cationic amphiphiles are required to inhibit EBOV entry into cells that overexpress NPC1 than parental cells, supporting the contention that they inhibit EBOV entry in an NPC1-dependent manner. A previously reported inhibitor, compound 3.47, inhibits EBOV entry by blocking binding of the EBOV glycoprotein to NPC1. None of the cationic amphiphiles tested had this effect. Hence, multiple cationic amphiphiles (including several FDA approved agents) inhibit EBOV entry in an NPC1-dependent fashion, but by a mechanism distinct from that of compound 3.47. Our findings suggest that there are minimally two ways of perturbing NPC1-dependent pathways that can block EBOV entry, increasing the attractiveness of NPC1 as an anti-filoviral therapeutic target.
C1 [Shoemaker, Charles J.; Schornberg, Kathryn L.; Delos, Sue E.; White, Judith M.] Univ Virginia, Dept Cell Biol, Charlottesville, VA 22903 USA.
[Scully, Corinne; Olinger, Gene G.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Pajouhesh, Hassan; Johansen, Lisa M.] Zalicus Inc, Cambridge, MA USA.
[White, Judith M.] Univ Virginia, Dept Microbiol, Charlottesville, VA 22908 USA.
RP White, JM (reprint author), Univ Virginia, Dept Cell Biol, Charlottesville, VA 22903 USA.
EM jw7g@virginia.edu
OI Olinger, Gene/0000-0001-7338-0292
FU DTRA [4.10007_08_RD_B, W81XWH-08-0051, W81XWH-12-P-0007]; National
Institutes of Health [U54 AI057168]
FX Work was supported by: DTRA project 4.10007_08_RD_B (G.G.O) and
subcontracts W81XWH-08-0051 (L.M.J) and W81XWH-12-P-0007(JMW) as well as
a grant from the National Institutes of Health: U54 AI057168 (J.M.W).
The funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
NR 63
TC 41
Z9 42
U1 2
U2 31
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 18
PY 2013
VL 8
IS 2
AR e56265
DI 10.1371/journal.pone.0056265
PG 13
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 092YP
UT WOS:000315159200028
PM 23441171
ER
PT J
AU Okusaga, O
Cahill, JP
Docherty, A
Menyuk, CR
Zhou, WM
AF Okusaga, Olukayode
Cahill, James P.
Docherty, Andrew
Menyuk, Curtis R.
Zhou, Weimin
TI Spontaneous inelastic Rayleigh scattering in optical fibers
SO OPTICS LETTERS
LA English
DT Article
AB Rayleigh scattering (RS) adds noise to signals that are transmitted over optical fibers and other optical waveguides. This noise can be the dominant noise source in a range between 10 Hz and 100 kHz from the carrier and can seriously degrade the performance of optical systems that require low close-in noise. Using heterodyne techniques, we demonstrate that the backscattered close-in noise spectrum in optical fibers is symmetric about the carrier and grows linearly with both input power and fiber length. These results indicate that the RS is spontaneous and is due to finite-lifetime thermal fluctuations in the glass. (c) 2013 Optical Society of America
C1 [Okusaga, Olukayode; Cahill, James P.; Zhou, Weimin] USA, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA.
[Cahill, James P.; Docherty, Andrew; Menyuk, Curtis R.] Univ Maryland Baltimore Cty, Comp Sci & Elect Engn Dept, Baltimore, MD 21250 USA.
RP Okusaga, O (reprint author), USA, Res Lab, Sensors & Elect Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM olukayode.k.okusaga.civ@mail.mil
FU DARPA; ARL; MPCA
FX The authors thank Dr. James Hanssen and Dr. Christopher Ekstrom of the
U.S. Naval Observatory for their invaluable assistance in developing the
heterodyne optical interferometer. Work at UMBC was supported by DARPA,
ARL, and MPCA.
NR 10
TC 8
Z9 8
U1 1
U2 12
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 0146-9592
J9 OPT LETT
JI Opt. Lett.
PD FEB 15
PY 2013
VL 38
IS 4
BP 549
EP 551
PG 3
WC Optics
SC Optics
GA 099EB
UT WOS:000315601700055
PM 23455132
ER
PT J
AU Boylan, GL
Goethals, PL
Cho, BR
AF Boylan, Gregory L.
Goethals, Paul L.
Cho, Byung Rae
TI Robust parameter design in resource-constrained environments: An
investigation of trade-offs between costs and precision within variable
processes
SO APPLIED MATHEMATICAL MODELLING
LA English
DT Article
DE Robust parameter design; Optimal design; Design of experiments; Monte
Carlo simulation; Nonlinear optimization
ID RESPONSE-SURFACE OPTIMIZATION; MODEL; OPTIMALITY; TAGUCHI; SYSTEMS
AB Engineers and scientists often identify robust parameter design as one of the most important process and quality improvement methods. Focused on statistical modeling and numerical optimization strategies, most researchers typically assume a process with reasonably small variability. Realistically, however, industrial processes often exhibit larger variability, particularly in mass production lines. In such cases, many of the modeling assumptions behind the robust parameter design models available in the literature do not hold. Accordingly, the results and recommendations provided to decision makers could generate suboptimal modifications to processes and products. As manufacturers seek improved methods for ensuring quality in resource-constrained environments, experimenters should examine trade-offs to achieve the levels of precision that best support their decision making. In contrast to previous research, this paper proposes a trade-off analysis between the cost of replication and the desired precision of generated solutions. We consider several techniques in the early stages of experimental design, using Monte Carlo simulation as a tool, for revealing potential options to the decision maker. This is perhaps the first study to show the avenue which may lead to more effective robust parameter design models with the optimal combination of cost constraints and desired precision of solutions. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Boylan, Gregory L.; Cho, Byung Rae] Clemson Univ, Dept Ind Engn, Adv Qual Engn Lab, Clemson, SC 29634 USA.
[Goethals, Paul L.] US Mil Acad, Dept Math Sci, West Point, NY 10997 USA.
RP Boylan, GL (reprint author), Clemson Univ, Dept Ind Engn, Adv Qual Engn Lab, Room 150,Freeman Hall, Clemson, SC 29634 USA.
EM gboylan@clemson.edu; paul.goethals@usma.edu; bcho@clemson.edu
NR 50
TC 2
Z9 2
U1 0
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0307-904X
J9 APPL MATH MODEL
JI Appl. Math. Model.
PD FEB 15
PY 2013
VL 37
IS 4
BP 2394
EP 2416
DI 10.1016/j.apm.2012.05.017
PG 23
WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary
Applications; Mechanics
SC Engineering; Mathematics; Mechanics
GA 073SW
UT WOS:000313763800064
ER
PT J
AU Luong, DD
Strbik, OM
Hammond, VH
Gupta, N
Cho, K
AF Luong, Dung D.
Strbik, Oliver M., III
Hammond, Vincent H.
Gupta, Nikhil
Cho, Kyu
TI Development of high performance lightweight aluminum alloy/SiC hollow
sphere syntactic foams and compressive characterization at quasi-static
and high strain rates
SO JOURNAL OF ALLOYS AND COMPOUNDS
LA English
DT Article
DE Metal-matrix composites (MMCs); Mechanical properties; Porosity;
Metallography
ID ASH CENOSPHERE COMPOSITES; DEFORMATION-BEHAVIOR; ENERGY-ABSORPTION;
MICROSTRUCTURE; MICROSPHERES; PROPERTY; IRON
AB Aluminum alloy A356 filled with silicon carbide hollow spheres (SiCHS) is investigated for quasi-static (10(-3) s(-1)) and high strain rate (up to 1520 s(-1)) compressive properties. Such closed cell composite foams, called syntactic foams, are of interest in weight sensitive structural applications. The present work is focused on understanding the compressive failure mechanism and relating them with the material microstructure. The compressive and plateau strengths of syntactic foams with SiCHS are found to be 163 and 110 MPa, respectively. The measured properties are considerably higher than the existing fly ash cenosphere filled aluminum matrix syntactic foams. Compressive failure mechanisms are studied for A356/SiCHS syntactic foams and direct evidence of hollow sphere crushing at the end of the elastic regions is obtained. The predictions of compressive strength obtained from an existing model are validated with the experimental results. Extensive analysis of data on open and closed cell foams containing gas porosity and syntactic foams is presented. A clear advantage in terms of low density and high yield strength is observed in A356/SiCHS syntactic foams compared to other foams. Yield strength of aluminum foams may be different at high strain rate compression compared to quasi-static values but most of the foams do not show strong evidence of strain rate sensitivity within the high strain rate regime. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Luong, Dung D.; Gupta, Nikhil] NYU, Polytech Inst, Dept Mech & Aerosp Engn, Composite Mat & Mech Lab, Brooklyn, NY 11201 USA.
[Strbik, Oliver M., III] Deep Springs Technol LLC, Toledo, OH 43615 USA.
[Hammond, Vincent H.; Cho, Kyu] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Gupta, N (reprint author), NYU, Polytech Inst, Dept Mech & Aerosp Engn, Composite Mat & Mech Lab, Brooklyn, NY 11201 USA.
EM ngupta@poly.edu
FU U.S. Army Research Laboratory [W911NF-10-2-0084]; DST
FX Portions of the research reported in this paper were performed in
connection with U.S. Army Research Laboratory contract W911NF-10-2-0084
with DST and Cooperative Working Agreement W911NF-11-2-0096 with
NYU-Poly. The views and conclusions contained in this presentation are
those of the authors and should not be interpreted as presenting the
official policies or position, either expressed or implied, of the ARL
or the U.S. Government unless so designated by other authorized
documents. Citation of manufacturers' or trade names does not constitute
an official endorsement or approval of the use notwithstanding any
copyright notation hereon.
NR 55
TC 41
Z9 41
U1 6
U2 95
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0925-8388
J9 J ALLOY COMPD
JI J. Alloy. Compd.
PD FEB 15
PY 2013
VL 550
BP 412
EP 422
DI 10.1016/j.jallcom.2012.10.171
PG 11
WC Chemistry, Physical; Materials Science, Multidisciplinary; Metallurgy &
Metallurgical Engineering
SC Chemistry; Materials Science; Metallurgy & Metallurgical Engineering
GA 051TG
UT WOS:000312149700068
ER
PT J
AU Chuang, I
Sedegah, M
Cicatelli, S
Spring, M
Polhemus, M
Tamminga, C
Patterson, N
Guerrero, M
Bennett, JW
McGrath, S
Ganeshan, H
Belmonte, M
Farooq, F
Abot, E
Banania, JG
Huang, J
Newcomer, R
Rein, L
Litilit, D
Richie, NO
Wood, C
Murphy, J
Sauerwein, R
Hermsen, CC
McCoy, AJ
Kamau, E
Cummings, J
Komisar, J
Sutamihardja, A
Shi, M
Epstein, JE
Maiolatesi, S
Tosh, D
Limbach, K
Angov, E
Bergmann-Leitner, E
Bruder, JT
Doolan, DL
King, CR
Carucci, D
Dutta, S
Soisson, L
Diggs, C
Hollingdale, MR
Ockenhouse, CF
Richie, TL
AF Chuang, Ilin
Sedegah, Martha
Cicatelli, Susan
Spring, Michele
Polhemus, Mark
Tamminga, Cindy
Patterson, Noelle
Guerrero, Melanie
Bennett, Jason W.
McGrath, Shannon
Ganeshan, Harini
Belmonte, Maria
Farooq, Fouzia
Abot, Esteban
Banania, Jo Glenna
Huang, Jun
Newcomer, Rhonda
Rein, Lisa
Litilit, Dianne
Richie, Nancy O.
Wood, Chloe
Murphy, Jittawadee
Sauerwein, Robert
Hermsen, Cornelus C.
McCoy, Andrea J.
Kamau, Edwin
Cummings, James
Komisar, Jack
Sutamihardja, Awalludin
Shi, Meng
Epstein, Judith E.
Maiolatesi, Santina
Tosh, Donna
Limbach, Keith
Angov, Evelina
Bergmann-Leitner, Elke
Bruder, Joseph T.
Doolan, Denise L.
King, C. Richter
Carucci, Daniel
Dutta, Sheetij
Soisson, Lorraine
Diggs, Carter
Hollingdale, Michael R.
Ockenhouse, Christian F.
Richie, Thomas L.
TI DNA Prime/Adenovirus Boost Malaria Vaccine Encoding P-falciparum CSP and
AMA1 Induces Sterile Protection Associated with Cell-Mediated Immunity
SO PLOS ONE
LA English
DT Article
ID APICAL MEMBRANE ANTIGEN-1; CYTOTOXIC T-LYMPHOCYTES; PHASE 2A TRIAL;
NAIVE ADULTS; CIRCUMSPOROZOITE PROTEIN; NEUTRALIZING ANTIBODIES;
SPOROZOITE INOCULATION; VIRUS ANKARA; DOUBLE-BLIND; IMMUNIZATION
AB Background: Gene-based vaccination using prime/boost regimens protects animals and humans against malaria, inducing cell-mediated responses that in animal models target liver stage malaria parasites. We tested a DNA prime/adenovirus boost malaria vaccine in a Phase 1 clinical trial with controlled human malaria infection.
Methodology/Principal Findings: The vaccine regimen was three monthly doses of two DNA plasmids (DNA) followed four months later by a single boost with two non-replicating human serotype 5 adenovirus vectors (Ad). The constructs encoded genes expressing P. falciparum circumsporozoite protein (CSP) and apical membrane antigen-1 (AMA1). The regimen was safe and well-tolerated, with mostly mild adverse events that occurred at the site of injection. Only one AE (diarrhea), possibly related to immunization, was severe (Grade 3), preventing daily activities. Four weeks after the Ad boost, 15 study subjects were challenged with P. falciparum sporozoites by mosquito bite, and four (27%) were sterilely protected. Antibody responses by ELISA rose after Ad boost but were low (CSP geometric mean titer 210, range 44-817; AMA1 geometric mean micrograms/milliliter 11.9, range 1.5-102) and were not associated with protection. Ex vivo IFN-gamma ELISpot responses after Ad boost were modest (CSP geometric mean spot forming cells/million peripheral blood mononuclear cells 86, range 13-408; AMA1 348, range 88-1270) and were highest in three protected subjects. ELISpot responses to AMA1 were significantly associated with protection (p = 0.019). Flow cytometry identified predominant IFN-gamma mono-secreting CD8+ T cell responses in three protected subjects. No subjects with high pre-existing anti-Ad5 neutralizing antibodies were protected but the association was not statistically significant.
Significance: The DNA/Ad regimen provided the highest sterile immunity achieved against malaria following immunization with a gene-based subunit vaccine (27%). Protection was associated with cell-mediated immunity to AMA1, with CSP probably contributing. Substituting a low seroprevalence vector for Ad5 and supplementing CSP/AMA1 with additional antigens may improve protection.
C1 [Chuang, Ilin; Sedegah, Martha; Tamminga, Cindy; Patterson, Noelle; McGrath, Shannon; Ganeshan, Harini; Belmonte, Maria; Farooq, Fouzia; Abot, Esteban; Banania, Jo Glenna; Huang, Jun; Litilit, Dianne; McCoy, Andrea J.; Sutamihardja, Awalludin; Epstein, Judith E.; Maiolatesi, Santina; Limbach, Keith; Doolan, Denise L.; Carucci, Daniel; Hollingdale, Michael R.; Richie, Thomas L.] USN, US Mil Malaria Vaccine Program, Med Res Ctr, Silver Spring, MD USA.
[Cicatelli, Susan; Spring, Michele; Polhemus, Mark; Guerrero, Melanie; Bennett, Jason W.; Newcomer, Rhonda; Rein, Lisa; Richie, Nancy O.; Wood, Chloe; Murphy, Jittawadee; Kamau, Edwin; Cummings, James; Komisar, Jack; Shi, Meng; Tosh, Donna; Angov, Evelina; Bergmann-Leitner, Elke; Dutta, Sheetij; Ockenhouse, Christian F.] Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD USA.
[Sauerwein, Robert; Hermsen, Cornelus C.] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands.
[Bruder, Joseph T.; King, C. Richter] GenVec Inc, Gaithersburg, MD USA.
[Soisson, Lorraine; Diggs, Carter] USAID, Washington, DC USA.
RP Richie, TL (reprint author), USN, US Mil Malaria Vaccine Program, Med Res Ctr, Silver Spring, MD USA.
EM thomas.richie@med.navy.mil
RI Sauerwein, Robert/C-8519-2013; Bennett, Jason/B-3547-2011;
Bergmann-Leitner, Elke/B-3548-2011; Doolan, Denise/F-1969-2015; Hermsen,
C.C./L-4368-2015;
OI Bergmann-Leitner, Elke/0000-0002-8571-8956; Richie,
Thomas/0000-0002-2946-5456
FU USAID "Development of Adenovirus-Vectored Malaria Vaccines"
[GHA-P-00-03-00006-01, 936-3118]; Congressionally Directed Medical
Research Program "Development of Recombinant Adenoviral-based Vaccines
against Malaria" [W81XWH-05-2-0041]; Military Infectious Research
Program "Phase 1/2a clinical trials assessing the safety, tolerability,
immunogenicity protective efficacy of Ad5-CA, a two-antigen,
adenovirus-vectored Plasmodium falciparum malaria vaccine, in healthy,
malaria-nave adults" [62787A 870 F 1432]
FX This work was supported by USAID "Development of Adenovirus-Vectored
Malaria Vaccines" Grant #: GHA-P-00-03-00006-01, Project Number
936-3118; and the Congressionally Directed Medical Research Program
"Development of Recombinant Adenoviral-based Vaccines against Malaria"
Grant #: W81XWH-05-2-0041.. Website: https://cdmrp.org. Military
Infectious Research Program "Phase 1/2a clinical trials assessing the
safety, tolerability, immunogenicity & protective efficacy of Ad5-CA, a
two-antigen, adenovirus-vectored Plasmodium falciparum malaria vaccine,
in healthy, malaria-nave adults", work unit number 62787A 870 F 1432.
The funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
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PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 14
PY 2013
VL 8
IS 2
AR e55571
DI 10.1371/journal.pone.0055571
PG 15
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 099EJ
UT WOS:000315602700019
PM 23457473
ER
PT J
AU Sirk, TW
Moore, S
Brown, EF
AF Sirk, Timothy W.
Moore, Stan
Brown, Eugene F.
TI Characteristics of thermal conductivity in classical water models
SO JOURNAL OF CHEMICAL PHYSICS
LA English
DT Article
ID NONEQUILIBRIUM MOLECULAR-DYNAMICS; LIQUID WATER; COULOMBIC SYSTEMS;
METHANE HYDRATE; EWALD METHOD; SIMULATION; MESH; POTENTIALS; EQUATIONS;
SUMMATION
AB The thermal conductivities of common water models are compared using equilibrium (EMD) and non-equilibrium molecular dynamics (NEMD) simulation. A complete accounting for electrostatic contributions to the heat flux was found to resolve the previously reported differing results of NEMD and EMD Green-Kubo measurements for the extended simple point-charge (SPC/E) model. Accordingly, we demonstrate the influence of long-range electrostatics on the thermal conductivity with a simple coulomb cutoff, Ewald summation, and by an extended particle-particle particle-mesh method. For each water model, the thermal conductivity is computed and decomposed in terms of frequency-dependent thermodynamic and topological contributions. The rigid, three-site SPC, SPC/E, and transferable intermolecular potential (TIP3P-Ew) water models are shown to have similar thermal conductivity values at standard conditions, whereas models that include bond stretching and angle bending have higher thermal conductivities. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4789961]
C1 [Sirk, Timothy W.] USA, Macromol Sci & Technol Branch, Res Lab, Aberdeen, MD 21005 USA.
[Moore, Stan] Sandia Natl Labs, Scalable Algorithms Dept, Albuquerque, NM 87185 USA.
[Brown, Eugene F.] Virginia Polytech Inst & State Univ, Dept Mech Engn, Blacksburg, VA 24061 USA.
RP Sirk, TW (reprint author), USA, Macromol Sci & Technol Branch, Res Lab, Aberdeen, MD 21005 USA.
EM tim.sirk@us.army.mil
RI Brown, Eugene/F-2017-2014
FU AREVA, Inc., North America of Lynchburg, Virginia; Center for Advanced
Engineering and Research, Forest, Virginia
FX The authors thank Steve Plimpton (Sandia National Laboratories) for
contributions to the LAMMPS implementation and Jan-Michael Carrillo
(University of Connecticut), for example Madelung calculations. Partial
support is acknowledged from an appointment to the Postgraduate Research
Participation Program at the U.S. Army Research Laboratory administered
by the Oak Ridge Institute for Science and Education through an
interagency agreement between the U.S. Department of Energy and the
USARL. Partial support is acknowledged from AREVA, Inc., North America
of Lynchburg, Virginia and the Center for Advanced Engineering and
Research, Forest, Virginia.
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PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0021-9606
J9 J CHEM PHYS
JI J. Chem. Phys.
PD FEB 14
PY 2013
VL 138
IS 6
AR 064505
DI 10.1063/1.4789961
PG 11
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA 091MS
UT WOS:000315054400027
PM 23425477
ER
PT J
AU Taylor, DE
Runge, K
Cory, MG
Burns, DS
Vasey, JL
Hearn, JD
Griffith, K
Henley, MV
AF Taylor, DeCarlos E.
Runge, Keith
Cory, Marshall G.
Burns, Douglas S.
Vasey, Joseph L.
Hearn, John D.
Griffith, Kara
Henley, Michael V.
TI Surface Binding of Organophosphates on Silica: Comparing Experiment and
Theory
SO JOURNAL OF PHYSICAL CHEMISTRY C
LA English
DT Article
ID DIMETHYL METHYLPHOSPHONATE; ADSORBED ORGANOPHOSPHONATES;
MOLECULAR-DYNAMICS; AMORPHOUS SILICA; AB-INITIO; ADSORPTION; SENSORS;
SIO2; ENERGIES; VAPOR
AB A consistent embedding hierarchy is applied to the calculation of binding enthalpies for organophosphate molecules to a silica surface and compared to experiment. The interaction of four probe molecules, dimethyl methylphosphonate (DMMP), diisopropyl methylphosphonate (DIMP), diisopropyl fluorophosphate (DFP), and sarin, with the silica surface is examined. Quantum chemical methods are employed to compute binding enthalpies and vibrational spectra for all interactions between probe molecules and silanol sites on the silica surface. Comparison with experimentally measured infrared shifts indicates that the theoretically modeled adsorption sites are similar to those found in experiment. The calculated binding enthalpies agree well with experiment for sarin, Delta H-ads,H-443K = -22.0 kcal/mol (calculated) vs -18.8 +/- 5,5 kcal/mol (measured, 433 K < T-expt < 453 K), and DIMP, Delta H-ads,H-463K = -26.9 kcal/mol (calculated) vs -29.3 +/- 0.9 kcal/mol (measured, 453 K < T-expt < 473 K). Agreement with experiment is less good for DMMP, Delta H-ads,H-463K = -19.7 kcal/mol (calculated) vs -26.1 +/- 1.5 kcal/mol (measured, 453 K < T-expt < 473 K), and DFP, Delta H-ads,H-423K = -20.4 kcal/mol (calculated) vs -27.5 +/- 3.1, kcal/mol (measured, 413 K < T-expt < 433 K).
C1 [Taylor, DeCarlos E.] USA, Res Lab, Weap & Mat Res Directorate, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA.
[Runge, Keith] BWD Associates LLC, Gainesville, FL 32653 USA.
[Cory, Marshall G.; Burns, Douglas S.; Vasey, Joseph L.] ENSCO Inc, Melbourne, FL 32940 USA.
[Hearn, John D.; Henley, Michael V.] US AFRL RXQL, Tyndall AFB, FL 32403 USA.
[Griffith, Kara] UTC Inc, Tyndall AFB, FL 32403 USA.
RP Runge, K (reprint author), BWD Associates LLC, 2901 Northwest 54th Ave, Gainesville, FL 32653 USA.
EM krunge@bellsouth.net
FU Defense Threat Reduction Agency (DTRA) [HDTRA1-10-C-0015]
FX This work was supported by the Defense Threat Reduction Agency (DTRA)
(Contract #: HDTRA1-10-C-0015). While this research has been funded by
the agency, the results and content of this publication do not
necessarily reflect the views and opinions of the funding agency.
NR 27
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PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1932-7447
J9 J PHYS CHEM C
JI J. Phys. Chem. C
PD FEB 14
PY 2013
VL 117
IS 6
BP 2699
EP 2708
DI 10.1021/jp306713d
PG 10
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA 093HH
UT WOS:000315181800038
ER
PT J
AU Hu, HT
Nau, M
Ehrenberg, P
Chenine, AL
Macedo, C
Zhou, Y
Daye, ZJ
Wei, Z
Vahey, M
Michael, NL
Kim, JH
Marovich, M
Ratto-Kim, S
AF Hu, Haitao
Nau, Martin
Ehrenberg, Phil
Chenine, Agnes-Laurence
Macedo, Camila
Zhou, Yu
Daye, Z. John
Wei, Zhi
Vahey, Maryanne
Michael, Nelson L.
Kim, Jerome H.
Marovich, Mary
Ratto-Kim, Silvia
TI Distinct gene-expression profiles associated with the susceptibility of
pathogen-specific CD4 T cells to HIV-1 infection
SO BLOOD
LA English
DT Article
ID HUMAN-IMMUNODEFICIENCY-VIRUS; PERIPHERAL-BLOOD;
MYCOBACTERIUM-TUBERCULOSIS; CYTOMEGALOVIRUS RETINITIS; REPLICATION;
RISK; INDIVIDUALS; ACTIVATION; DEPLETION; PROTEIN
AB In HIV infection, CD4 responses to opportunistic pathogens such as Candida albicans are lost early, but CMV-specific CD4 response persists. Little is currently known about HIV infection of CD4 T cells of different pathogen/antigen specificities. CFSE-labeled PBMCs were stimulated with CMV, tetanus toxoid (TT), and C albicans antigens and subsequently exposed to HIV. HIV infection was monitored by intracellular p24 in CFSElow population. We found that although TT- and C albicans-specific CD4 T cells were permissive, CMV-specific CD4 T cells were highly resistant to both R5 and X4 HIV. Quantification of HIV DNA in CFSElow cells showed a reduction of strong-stop and full-length DNA in CMV-specific cells compared with TT- and C albicans-specific cells. beta-Chemokine neutralization enhanced HIV infection in TT- and C albicans-specific cells, whereas HIV infection in CMV-specific cells remained low despite increased entry by beta-chemokine neutralization, suggesting postentry HIV restriction by CMV-specific cells. Microarray analysis (Gene Expression Omnibus accession number: GSE42853) revealed distinct transcriptional profiles that involved selective up-regulation of comprehensive innate antiviral genes in CMV-specific cells, whereas TT- and C albicans-specific cells mainly up-regulated Th17 inflammatory response. Our data suggest a mechanism for the persistence of CMV-specific CD4 response and earlier loss of mucosal Th17-associated TT- and C albicans-specific CD4 response in AIDS. (Blood. 2013; 121(7): 1136-1144)
C1 [Hu, Haitao; Nau, Martin; Ehrenberg, Phil; Chenine, Agnes-Laurence; Macedo, Camila; Vahey, Maryanne; Michael, Nelson L.; Kim, Jerome H.; Marovich, Mary; Ratto-Kim, Silvia] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
[Zhou, Yu] Temple Univ, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19122 USA.
[Daye, Z. John] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Div Epidemiol & Biostat, Tucson, AZ USA.
[Wei, Zhi] New Jersey Inst Technol, Dept Comp Sci, Newark, NJ 07102 USA.
RP Hu, HT (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM hhu@hivresearch.org
FU Henry M. Jackson Foundation [W81XWH-07-2-0067]; US Department of Defense
FX The work was supported by a cooperative agreement (W81XWH-07-2-0067)
between the Henry M. Jackson Foundation and the US Department of
Defense.
NR 49
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U1 0
U2 9
PU AMER SOC HEMATOLOGY
PI WASHINGTON
PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA
SN 0006-4971
J9 BLOOD
JI Blood
PD FEB 14
PY 2013
VL 121
IS 7
BP 1136
EP 1144
DI 10.1182/blood-2012-07-446278
PG 9
WC Hematology
SC Hematology
GA 088XH
UT WOS:000314870700017
PM 23258923
ER
PT J
AU Zhang, BG
Li, YJ
Liu, R
Pritchett, TM
Haley, JE
Sun, WF
AF Zhang, Bingguang
Li, Yunjing
Liu, Rui
Pritchett, Timothy M.
Haley, Joy E.
Sun, Wenfang
TI Extending the Bandwidth of Reverse Saturable Absorption in Platinum
Complexes Using Two-Photon-Initiated Excited-State Absorption
SO ACS APPLIED MATERIALS & INTERFACES
LA English
DT Article
DE platinum(II) terpyridine complex; photophysics; excited-state
absorption; two-photon absorption; reverse saturable absorption;
nonlinear absorbing materials
ID PT-ETHYNYL COMPOUND; 2-PHOTON ABSORPTION; CROSS-SECTION; OPTICAL
NONLINEARITIES; ORGANIC-MOLECULES; PORPHYRIN DIMERS; PHOTOPHYSICS;
DERIVATIVES; DYES; PHTHALOCYANINES
AB Pt(II) complexes bearing 4-(7-(benzothiazol-2'-yl)-9,9-diethylfluoren-2-yl)-2,2':6',2 ''-terpyridine or 4-(7-(benzothiazol-2'-yl)-9,9-diethylfluoren-2-yl)ethynyl-2,2':6',2 ''-terpyridine ligand exhibit strong reverse saturable absorption in the visible spectral region and large two-photon initiated excited-state absorption in the near-IR region. They are promising broadband nonlinear absorbing materials from the visible to the near-IR region. The extended pi-conjugation in complex 2 that has a C C linker between the terpyridine ligand and the 4-(7-(benzothiazol-2'-yl)-9,9-diethylfluoren-2-yl) substituent significantly increases the two-photon absorption cross sections (sigma(2)), making it among the strongest of two-photon absorbing Pt(II) complexes.
C1 [Zhang, Bingguang; Li, Yunjing; Liu, Rui; Sun, Wenfang] N Dakota State Univ, Dept Chem & Biochem, Fargo, ND 58108 USA.
[Pritchett, Timothy M.] USA, Res Lab, AMSRD SEE M, Adelphi, MD 20783 USA.
[Haley, Joy E.] USAF, Mat & Mfg Directorate, Res Lab, Dayton, OH 45433 USA.
RP Sun, WF (reprint author), N Dakota State Univ, Dept Chem & Biochem, Fargo, ND 58108 USA.
EM Wenfang.Sun@ndsu.edu
RI Liu, Rui/G-3772-2014
FU Army Research Laboratory [W911NF-06-2-0032, W911NF-10-2-0055]; National
Science Foundation [CHE-0449598]
FX This work is partially supported by the Army Research Laboratory (Grants
W911NF-06-2-0032 and W911NF-10-2-0055). We also acknowledge the support
from the National Science Foundation (Grant CAREER CHE-0449598) for
partial support.
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U1 4
U2 41
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1944-8244
J9 ACS APPL MATER INTER
JI ACS Appl. Mater. Interfaces
PD FEB 13
PY 2013
VL 5
IS 3
BP 565
EP 572
DI 10.1021/am3018724
PG 8
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
SC Science & Technology - Other Topics; Materials Science
GA 091WE
UT WOS:000315079700015
PM 23273050
ER
PT J
AU Peterson, AM
Jensen, RE
Palmese, GR
AF Peterson, Amy M.
Jensen, Robert E.
Palmese, Giuseppe R.
TI Kinetic Considerations for Strength Recovery at the Fiber-Matrix
Interface Based on the Diels-Alder Reaction
SO ACS APPLIED MATERIALS & INTERFACES
LA English
DT Article
DE Diels-Alder reaction; self-healing polymer; fiber-reinforced polymer
composite; fiber-matrix interface; thermoset; glass transition
temperature
ID SHEAR-STRENGTH; POLYMER; EPOXY; COMPOSITES; PERFORMANCE; THERMOSETS;
LINKERS; AGENTS; GELS
AB The Diels-Alder reaction was used to yield thermal reversibility of the bonding between a partially furan-functionalized epoxy thermosetting matrix and a maleimide-treated glass fiber. Under ambient temperature conditions, the covalent bond forming product reaction dominates, but this reaction reverses at elevated temperatures to allow for interfacial healing. Single-fiber microdroplet pull-out testing was used to characterize the coupled effects of healing temperature and the glass transition temperature (T-g) of the epoxy on interfacial strength recovery. In particular, the roles of mobility and reaction kinetics were independently varied to understand the individual effects of both.
C1 [Peterson, Amy M.; Palmese, Giuseppe R.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA.
[Jensen, Robert E.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Palmese, GR (reprint author), Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA.
EM palmese@coe.drexel.edu
RI Peterson, Amy/A-2945-2012
OI Peterson, Amy/0000-0002-4612-0062
FU U.S. Army Research Laboratory under the Army Materials Center of
Excellence Program [W911NF-06-2-0013]; National Science Foundation
Graduate Research Fellowship
FX This research was supported by the U.S. Army Research Laboratory under
the Army Materials Center of Excellence Program, Contract
W911NF-06-2-0013. Amy Peterson was supported in part by a National
Science Foundation Graduate Research Fellowship. The authors thank the
U.S. Army Research Laboratory for use of the single-fiber microdroplet
pull-out testing apparatus as well as Daphne Pappas at the US Army
Research Laboratory for XPS analysis.
NR 30
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U1 6
U2 61
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1944-8244
J9 ACS APPL MATER INTER
JI ACS Appl. Mater. Interfaces
PD FEB 13
PY 2013
VL 5
IS 3
BP 815
EP 821
DI 10.1021/am302383v
PG 7
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
SC Science & Technology - Other Topics; Materials Science
GA 091WE
UT WOS:000315079700047
PM 23317573
ER
PT J
AU Kumar, R
Sides, SW
Goswami, M
Sumpter, BG
Hong, KL
Wu, XD
Russell, TP
Gido, SP
Misichronis, K
Rangou, S
Avgeropoulos, A
Tsoukatos, T
Hadjichristidis, N
Beyer, FL
Mays, JW
AF Kumar, Rajeev
Sides, Scott W.
Goswami, Monojoy
Sumpter, Bobby G.
Hong, Kunlun
Wu, Xiaodong
Russell, Thomas P.
Gido, Samuel P.
Misichronis, Konstantinos
Rangou, Sofia
Avgeropoulos, Apostolos
Tsoukatos, Thodoris
Hadjichristidis, Nikos
Beyer, Frederick L.
Mays, Jimmy W.
TI Morphologies of ABC Triblock Terpolymer Melts Containing
Poly(Cyclohexadiene): Effects of Conformational Asymmetry
SO LANGMUIR
LA English
DT Article
ID BLOCK-COPOLYMER MELTS; LIVING ANIONIC-POLYMERIZATION; CONSISTENT-FIELD
THEORY; DIBLOCK COPOLYMERS; PHASE-BEHAVIOR; NETWORK PHASES;
N-BUTYLLITHIUM/N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE SYSTEM;
1,3-CYCLOHEXADIENE POLYMERS; MICROPHASE SEPARATION; MULTIPHASE
MORPHOLOGY
AB We have synthesized linear ABC triblock terpolymers containing poly(1,3-cyclohexadiene), PCHD, as an end block and characterized their morphologies in the melt. Specifically, we have studied terpolymers containing polystyrene (PS), polybutadiene (PB), and polyisoprene (PI) as the other blocks. Systematically varying the ratio of 1,2- /1,4-microstructures of poly(1,3-cyclohexadiene), we have studied the effects of conformational asymmetry among the three blocks on the morphologies using transmission electron microscopy (TEM), small-angle X-ray scattering (SAXS), and self-consistent field theory (SCFT) performed with PolySwift++. Our work reveals that the triblock terpolymer melts containing a high percentage of 1,2-microstructures in the PCHD block are disordered at 110 degrees C for all the samples, independent of sequence and volume fraction of the blocks. In contrast, the triblock terpolymer melts containing a high percentage of 1,4-microstructure form regular morphologies known from the literature. The accuracy of the SCFT calculations depends on calculating the chi parameters that quantify the repulsive interactions between different monomers. Simulations using chi values obtained from solubility parameters and group contribution methods are unable to reproduce the morphologies as seen in the experiments. However, SCFT calculations accounting for the enhancement of the chi parameter with an increase in the conformational asymmetry lead to an excellent agreement between theory and experiments. These results highlight the importance of conformational asymmetry in tuning the chi parameter and, in turn, morphologies in block copolymers.
C1 [Kumar, Rajeev] Oak Ridge Natl Lab, Natl Ctr Computat Sci, Oak Ridge, TN 37831 USA.
[Sides, Scott W.] Tech X Corp, Boulder, CO 80303 USA.
[Goswami, Monojoy] Oak Ridge Natl Lab, Comp Sci & Math Div, Oak Ridge, TN 37831 USA.
[Sumpter, Bobby G.; Hong, Kunlun] Oak Ridge Natl Lab, Ctr Nanophase Mat Sci, Oak Ridge, TN 37831 USA.
[Wu, Xiaodong; Russell, Thomas P.; Gido, Samuel P.] Univ Massachusetts, Polymer Sci & Engn Dept, Amherst, MA 01003 USA.
[Misichronis, Konstantinos; Rangou, Sofia; Avgeropoulos, Apostolos] Univ Ioannina, Dept Mat Sci & Engn, GR-45110 Ioannina, Greece.
[Tsoukatos, Thodoris; Hadjichristidis, Nikos] Univ Athens Panepistimiopolis, Dept Chem, Athens 15771, Greece.
[Beyer, Frederick L.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Mays, Jimmy W.] Univ Tennessee, Dept Chem, Knoxville, TN 37996 USA.
RP Kumar, R (reprint author), Oak Ridge Natl Lab, Natl Ctr Computat Sci, Oak Ridge, TN 37831 USA.
EM kumarr@ornl.gov
RI Sumpter, Bobby/C-9459-2013; Goswami, Monojoy/G-7943-2012; Hong,
Kunlun/E-9787-2015; KUMAR, RAJEEV/D-2562-2010; Avgeropoulos,
Apostolos/I-5772-2012; Kumar, Rajeev/Q-2255-2015
OI Sumpter, Bobby/0000-0001-6341-0355; Goswami,
Monojoy/0000-0002-4473-4888; Hong, Kunlun/0000-0002-2852-5111;
Misichronis, Konstantinos/0000-0002-2620-1738; Kumar,
Rajeev/0000-0001-9494-3488
FU Materials Science and Engineering Division, U.S. Department of Energy
(DoE), Office of Basic Energy Sciences (BES) [DEAC05-00OR22725];
UT-Battelle, LLC, at Oak Ridge National Laboratory (ORNL); Scientific
User Facilities Division of DOE
FX This work was supported by the Materials Science and Engineering
Division, U.S. Department of Energy (DoE), Office of Basic Energy
Sciences (BES) under Contract No. DEAC05-00OR22725 with UT-Battelle,
LLC, at Oak Ridge National Laboratory (ORNL). Part of the research was
done at the Center for Nanophase Materials Sciences, which is sponsored
by the Scientific User Facilities Division of DOE. This research used
resources of the Oak Ridge Leadership Computing Facility at the ORNL.
NR 73
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U1 5
U2 112
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0743-7463
J9 LANGMUIR
JI Langmuir
PD FEB 12
PY 2013
VL 29
IS 6
BP 1995
EP 2006
DI 10.1021/la304576c
PG 12
WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science,
Multidisciplinary
SC Chemistry; Materials Science
GA 090ZJ
UT WOS:000315018200034
PM 23259866
ER
PT J
AU Yerry, J
Lewis, S
Finkel, A
AF Yerry, Juanita
Lewis, Steven
Finkel, Alan
TI Safety of Onabotulinum Toxin A for the Treatment of Chronic
Post-Traumatic Headache in Service Members with a History of Mild
Traumatic Brain Injury
SO NEUROLOGY
LA English
DT Meeting Abstract
CT 65th Annual Meeting of the American-Academy-of-Neurology (AAN)
CY MAR 16-23, 2013
CL San Diego, CA
SP Amer Acad Neurol
C1 [Yerry, Juanita; Lewis, Steven] Womack Army Med Ctr, Concuss Care Clin, Ft Bragg, NC USA.
[Finkel, Alan] Def & Vet Brain Injury Ctr, Concuss Care Clin, Ft Bragg, NC USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0028-3878
EI 1526-632X
J9 NEUROLOGY
JI Neurology
PD FEB 12
PY 2013
VL 80
SU S
MA P01076
PG 1
WC Clinical Neurology
SC Neurosciences & Neurology
GA AB8VR
UT WOS:000332068600233
ER
PT J
AU Yurek, S
DeAngelis, DL
Trexler, JC
Jopp, F
Donalson, DD
AF Yurek, Simeon
DeAngelis, Donald L.
Trexler, Joel C.
Jopp, Fred
Donalson, Douglas D.
TI Simulating mechanisms for dispersal, production and stranding of small
forage fish in temporary wetland habitats
SO ECOLOGICAL MODELLING
LA English
DT Article
DE Spatially explicit model; Fish movement strategies; Small fish
community; Ephemeral habitats; Dynamic biomass distributions; Trophic
web structure
ID FRESH-WATER MARSH; FLORIDA-EVERGLADES; COMMUNITY STRUCTURE;
SPATIOTEMPORAL PATTERNS; OLIGOTROPHIC WETLAND; TROPHIC INTERACTIONS;
WADING BIRDS; ECOSYSTEM; RESTORATION; DISTURBANCE
AB Movement strategies of small forage fish (<8 cm total length) between temporary and permanent wetland habitats affect their overall population growth and biomass concentrations, i.e., availability to predators. These fish are often the key energy link between primary producers and top predators, such as wading birds, which require high concentrations of stranded fish in accessible depths. Expansion and contraction of seasonal wetlands induce a sequential alternation between rapid biomass growth and concentration, creating the conditions for local stranding of small fish as they move in response to varying water levels. To better understand how landscape topography, hydrology, and fish behavior interact to create high densities of stranded fish, we first simulated population dynamics of small fish, within a dynamic food web, with different traits for movement strategy and growth rate, across an artificial, spatially explicit, heterogeneous, two-dimensional marsh slough landscape, using hydrologic variability as the driver for movement. Model output showed that fish with the highest tendency to invade newly flooded marsh areas built up the largest populations over long time periods with stable hydrologic patterns. A higher probability to become stranded had negative effects on long-term population size, and offset the contribution of that species to stranded biomass. The model was next applied to the topography of a 10 km x 10 km area of Everglades landscape. The details of the topography were highly important in channeling fish movements and creating spatiotemporal patterns of fish movement and stranding. This output provides data that can be compared in the future with observed locations of fish biomass concentrations, or such surrogates as phosphorus 'hotspots' in the marsh. Published by Elsevier B.V.
C1 [Yurek, Simeon; DeAngelis, Donald L.] Univ Miami, Dept Biol, Cox Sci Ctr, Coral Gables, FL 33124 USA.
[DeAngelis, Donald L.] Univ Miami, US Geol Survey, Southeast Ecol Sci Ctr, Coral Gables, FL 33124 USA.
[Trexler, Joel C.] Florida Int Univ, Dept Biol Sci, North Miami, FL 33181 USA.
[Donalson, Douglas D.] USA, Corps Engineers, Jacksonville, FL 32202 USA.
[Jopp, Fred] Univ Giessen, Dept Anim Ecol, IFZ, D-35392 Giessen, Germany.
RP Yurek, S (reprint author), Univ Miami, Dept Biol, Cox Sci Ctr, 1301 Mem Dr, Coral Gables, FL 33124 USA.
EM syurek@bio.miami.edu; don_deangelis@usgs.gov; trexlerj@fiu.edu;
fred.jopp@gmail.com; douglas.d.donalson@usace.army.mil
FU USGS Greater Everglades Priority Ecosystem Science Program; USGS Future
Impacts of Sea Level Rise on Coastal Habitats and Species project;
Department of the Army [W912HZ-10-2-0033]; U.S. Army Engineer Research
and Development Center (ERDC) [W912HZ-10-2-0033]; Florida International
University [W912HZ-10-2-0033]; National Science Foundation [DEB-9910514]
FX We thank William F. Loftus, Joseph Serafy, and two anonymous reviewers
for useful comments and suggestions. S. Yurek was supported by the USGS
Greater Everglades Priority Ecosystem Science Program and by the USGS
Future Impacts of Sea Level Rise on Coastal Habitats and Species
project. J.C. Trexler was supported by cooperative agreement
W912HZ-10-2-0033 between the Department of the Army, U.S. Army Engineer
Research and Development Center (ERDC) and Florida International
University while working on this project. This material was developed in
collaboration with the Florida Coastal Everglades Long-Term Ecological
Research program under National Science Foundation Grant No.
DEB-9910514. Any use of trade, product, or firm names is for descriptive
purposes only and does not imply endorsement by the U. S. Government.
NR 57
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U2 41
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-3800
J9 ECOL MODEL
JI Ecol. Model.
PD FEB 10
PY 2013
VL 250
BP 391
EP 401
DI 10.1016/j.ecolmodel.2012.11.001
PG 11
WC Ecology
SC Environmental Sciences & Ecology
GA 094EP
UT WOS:000315246100037
ER
PT J
AU Salemi, S
Goldsman, N
Ettisserry, DP
Akturk, A
Lelis, A
AF Salemi, S.
Goldsman, N.
Ettisserry, D. P.
Akturk, A.
Lelis, A.
TI The effect of defects and their passivation on the density of states of
the 4H-silicon-carbide/silicon-dioxide interface
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
ID SIC/SIO2 INTERFACE; NITRIDATION; N2O
AB The 4H-SiC(0001)/SiO2 interface has a variety of likely defects as reported in the literature. We investigate the defects at the SiC side of the interface using density functional theory. We also investigate the effects of passivating these states. The defects studied include a single carbon interstitial, a carbon pair interstitial, and a silicon vacancy at the interface. Density functional theory has been employed to calculate the total and projected density of states (pDOS) and the energy levels of the defects. The results of our calculations indicate that a carbon interstitial and a pair of carbons give rise to traps near the conduction band and valence band. The silicon vacancy gives rise to traps that are closer to the valence band. The effects of hydrogen and nitrogen passivation on the defect energy levels have been investigated. Our studies indicate that hydrogen and nitrogen passivation can eliminate states near the conduction and valence bands, although in some cases they may introduce levels in the midgap. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4789615]
C1 [Salemi, S.] Univ Maryland, Dept Reliabil Engn, College Pk, MD 20742 USA.
[Goldsman, N.; Ettisserry, D. P.; Akturk, A.] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA.
[Lelis, A.] USA, Res Lab, Adelphi, MD 20783 USA.
RP Goldsman, N (reprint author), Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA.
EM neil@umd.edu
OI Ettisserry, Devanarayanan/0000-0002-4214-2141
NR 21
TC 8
Z9 8
U1 1
U2 43
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0021-8979
J9 J APPL PHYS
JI J. Appl. Phys.
PD FEB 7
PY 2013
VL 113
IS 5
AR 053703
DI 10.1063/1.4789615
PG 6
WC Physics, Applied
SC Physics
GA 087FH
UT WOS:000314746200032
ER
PT J
AU Barault, L
Ellsworth, RE
Harris, HR
Valente, AL
Shriver, CD
Michels, KB
AF Barault, Ludovic
Ellsworth, Rachel E.
Harris, Holly R.
Valente, Allyson L.
Shriver, Craig D.
Michels, Karin B.
TI Leukocyte DNA as Surrogate for the Evaluation of Imprinted Loci
Methylation in Mammary Tissue DNA
SO PLOS ONE
LA English
DT Article
ID GROWTH-FACTOR-II; COLORECTAL-CANCER; BREAST-CANCER; IGF2 GENE;
EXPRESSION; H19; HYPOMETHYLATION; STABILITY; PATTERNS; DISEASE
AB There is growing interest in identifying surrogate tissues to identify epimutations in cancer patients since primary target tissues are often difficult to obtain. Methylation patterns at imprinted loci are established during gametogenesis and post fertilization and their alterations have been associated with elevated risk of cancer. Methylation at several imprinted differentially methylated regions (GRB10 ICR, H19 ICR, KvDMR, SNRPN/SNURF ICR, IGF2 DMR0, and IGF2 DMR2) were analyzed in DNA from leukocytes and mammary tissue (normal, benign diseases, or malignant tumors) from 87 women with and without breast cancer (average age of cancer patients: 53; range: 31-77). Correlations between genomic variants and DNA methylation at the studied loci could not be assessed, making it impossible to exclude such effects. Methylation levels observed in leukocyte and mammary tissue DNA were close to the 50% expected for monoallellic methylation. While no correlation was observed between leukocyte and mammary tissue DNA methylation for most of the analyzed imprinted genes, Spearman's correlations were statistically significant for IGF2 DMR0 and IGF2 DMR2, although absolute methylation levels differed. Leukocyte DNA methylation levels of selected imprinted genes may therefore serve as surrogate markers of DNA methylation in cancer tissue.
C1 [Barault, Ludovic; Harris, Holly R.; Michels, Karin B.] Harvard Univ, Brigham & Womens Hosp, Obstet & Gynecol Epidemiol Ctr, Sch Med,Dept Obstet Gynecol & Reprod Biol, Boston, MA 02115 USA.
[Ellsworth, Rachel E.] Henry M Jackson Fdn Adv Mil Med, Clin Breast Care Project, Windber, PA USA.
[Valente, Allyson L.] Windber Res Inst, Clin Breast Care Project, Windber, PA USA.
[Shriver, Craig D.] Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC 20307 USA.
[Michels, Karin B.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
RP Barault, L (reprint author), Harvard Univ, Brigham & Womens Hosp, Obstet & Gynecol Epidemiol Ctr, Sch Med,Dept Obstet Gynecol & Reprod Biol, Boston, MA 02115 USA.
EM Ludovic.barault@ircc.it
RI Barault, Ludovic/J-2472-2016
OI Barault, Ludovic/0000-0001-5227-5047
FU National Cancer Institute, National Institutes of Health, Department of
Health and Human Services [R03CA143967]; Breast Cancer Research
Foundation
FX This work was supported by a research grant from the National Cancer
Institute, National Institutes of Health, Department of Health and Human
Services [R03CA143967 to KBM]; and the Breast Cancer Research Foundation
(to KBM). The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
NR 36
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U1 0
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 7
PY 2013
VL 8
IS 2
AR e55896
DI 10.1371/journal.pone.0055896
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 092XV
UT WOS:000315157200084
PM 23409079
ER
PT J
AU Mac Donald, C
Johnson, A
Cooper, D
Malone, T
Sorrell, J
Shimony, J
Parsons, M
Snyder, A
Raichle, M
Fang, R
Flaherty, S
Russell, M
Brody, DL
AF Mac Donald, Christine
Johnson, Ann
Cooper, Dana
Malone, Thomas
Sorrell, James
Shimony, Joshua
Parsons, Matthew
Snyder, Abraham
Raichle, Marcus
Fang, Raymond
Flaherty, Stephen
Russell, Michael
Brody, David L.
TI Cerebellar White Matter Abnormalities following Primary Blast Injury in
US Military Personnel
SO PLOS ONE
LA English
DT Article
ID TRAUMATIC BRAIN-INJURY; POSTTRAUMATIC-STRESS-DISORDER; EXPLOSIVE BLAST;
WAR VETERANS; HEAD-INJURY; EXPOSURE; SEQUELAE; COMBAT; SCALE; IRAQI
AB Little is known about the effects of blast exposure on the human brain in the absence of head impact. Clinical reports, experimental animal studies, and computational modeling of blast exposure have suggested effects on the cerebellum and brainstem. In US military personnel with isolated, primary blast-related 'mild' traumatic brain injury and no other known insult, we found diffusion tensor MRI abnormalities consistent with cerebellar white matter injury in 3 of 4 subjects. No abnormalities in other brain regions were detected. These findings add to the evidence supporting the hypothesis that primary blast exposure contributes to brain injury in the absence of head impact and that the cerebellum may be particularly vulnerable. However, the clinical effects of these abnormalities cannot be determined with certainty; none of the subjects had ataxia or other detected evidence of cerebellar dysfunction. The details of the blast events themselves cannot be disclosed at this time, thus additional animal and computational modeling will be required to dissect the mechanisms underlying primary blast-related traumatic brain injury. Furthermore, the effects of possible subconcussive impacts and other military-related exposures cannot be determined from the data presented. Thus many aspects of topic will require further investigation.
C1 [Mac Donald, Christine; Johnson, Ann; Cooper, Dana; Malone, Thomas; Sorrell, James; Brody, David L.] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA.
[Shimony, Joshua; Parsons, Matthew; Snyder, Abraham; Raichle, Marcus] Washington Univ, Sch Med, Dept Radiol, St Louis, MO 63110 USA.
[Fang, Raymond; Flaherty, Stephen] Landstuhl Reg Med Ctr, Dept Trauma Surg, Landstuhl, Germany.
[Russell, Michael] USA, Rehabil & Reintegrat Div, San Antonio, TX USA.
RP Brody, DL (reprint author), Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA.
EM brodyd@neuro.wustl.edu
FU Congressionally Directed Medical Research Program [W81XWH-08-2-0061];
United States National Institutes of Health [F32NS062529, 5K23HD053212,
P30NS048056, P50NS06833, 5K08NS49237]; U.S. Army Medical Research
Acquisition Activity [W81XWH-09-2-0057]
FX The study was supported by grants from the Congressionally Directed
Medical Research Program (W81XWH-08-2-0061, to Dr. Brody), the United
States National Institutes of Health (F32NS062529, to Dr. Mac Donald;
5K23HD053212, to Dr. Shimony; P30NS048056, to Dr. Snyder; P50NS06833, to
Drs. Raichle and Snyder; and 5K08NS49237, to Dr. Brody) and U.S. Army
Medical Research Acquisition Activity (W81XWH-09-2-0057) to Dr. Russell,
under a protocol approved by Brooke Army Medical Center, San Antonio,
TX. The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
NR 53
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U1 1
U2 15
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 7
PY 2013
VL 8
IS 2
AR e55823
DI 10.1371/journal.pone.0055823
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 092XV
UT WOS:000315157200070
PM 23409052
ER
PT J
AU Beaudet, TD
Mattson, WD
Rice, BM
AF Beaudet, Todd D.
Mattson, William D.
Rice, Betsy M.
TI New form of polymeric nitrogen from dynamic shock simulation
SO JOURNAL OF CHEMICAL PHYSICS
LA English
DT Article
ID SPACE GAUSSIAN PSEUDOPOTENTIALS; SOLID MOLECULAR NITROGEN; VIBRATIONAL
DYNAMICS; HIGH-PRESSURES; PHASE; GPA; TRANSFORMATION; CRYSTALLINE; MBAR
AB For many years there has been significant interest in polymeric phases of nitrogen at low pressure for potential application as an energetic material. This was the result of years of theoretical work indicating potentially meta-stable polymeric nitrogen. Experimental evidence of both an amorphous phase and a cubic-gauche phase has added greatly to this interest [A. F. Goncharov, E. A. Gregoryanz, H. K. Mao, Z. Liu, and R. J. Hemley, Phys. Rev. Lett. 85, 1262 (2000); M. I. Eremets, R. J. Hemley, H. K. Mao, and E. Gregoryanz, Nature (London) 411, 170 (2001)]. While most of the theoretical work has been done on the many crystal phases of nitrogen, little work has been done on simulating amorphous polymeric nitrogen. The original goal of this work was to simulate amorphous polymeric nitrogen at low pressure; however, we unexpectedly found a new form of polymeric nitrogen. Starting from first principles dynamic shock simulation of cubic-gauche nitrogen [W. D. Mattson and R. Balu, Phys. Rev. B 83, 174105 (2011)] we demonstrate a new low pressure porous form that exhibits stability at low temperatures. We describe the detailed procedure of obtaining this structure as well as some of its physical characteristics. Finally, we explore composite structures of this new form of polymeric nitrogen and their possible relationship to an amorphous form. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4789307]
C1 [Beaudet, Todd D.; Mattson, William D.; Rice, Betsy M.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Beaudet, TD (reprint author), USA, Res Lab, RDRL WMM E Bldg 4600, Aberdeen Proving Ground, MD 21005 USA.
FU U.S. Army Research Laboratory
FX Calculations were performed using the DOD Supercomputing Resource
Centers (DSRCs) located at the U.S. Army Research Laboratory and the Air
Force Research Laboratory administered by the DOD High Performance
Computing Modernization Program. This research was supported in part by
an appointment to the U.S. Army Research Laboratory Postdoctoral
Fellowship Program administered by the Oak Ridge Associated Universities
through a contract with the U.S. Army Research Laboratory. The authors
thank Dr. Edward F. C. Byrd, Dr. DeCarlos Taylor, and Dr. Tanya
Chantawansri of the Army Research Laboratory for helpful discussions.
NR 61
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U2 53
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0021-9606
EI 1089-7690
J9 J CHEM PHYS
JI J. Chem. Phys.
PD FEB 7
PY 2013
VL 138
IS 5
AR 054503
DI 10.1063/1.4789307
PG 8
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA 087FJ
UT WOS:000314746400040
PM 23406129
ER
PT J
AU Ben Salah, A
Ben Messaoud, N
Guedri, E
Zaatour, A
Ben Alaya, N
Bettaieb, J
Gharbi, A
Hamida, NB
Boukthir, A
Chlif, S
Abdelhamid, K
El Ahmadi, Z
Louzir, H
Mokni, M
Morizot, G
Buffet, P
Smith, PL
Kopydlowski, KM
Kreishman-Deitrick, M
Smith, KS
Nielsen, CJ
Ullman, DR
Norwood, JA
Thorne, GD
McCarthy, WF
Adams, RC
Rice, RM
Tang, D
Berman, J
Ransom, J
Magill, AJ
Grogl, M
AF Ben Salah, Afif
Ben Messaoud, Nathalie
Guedri, Evelyn
Zaatour, Amor
Ben Alaya, Nissaf
Bettaieb, Jihene
Gharbi, Adel
Hamida, Nabil Belhadj
Boukthir, Aicha
Chlif, Sadok
Abdelhamid, Kidar
El Ahmadi, Zaher
Louzir, Hechmi
Mokni, Mourad
Morizot, Gloria
Buffet, Pierre
Smith, Philip L.
Kopydlowski, Karen M.
Kreishman-Deitrick, Mara
Smith, Kirsten S.
Nielsen, Carl J.
Ullman, Diane R.
Norwood, Jeanne A.
Thorne, George D.
McCarthy, William F.
Adams, Ryan C.
Rice, Robert M.
Tang, Douglas
Berman, Jonathan
Ransom, Janet
Magill, Alan J.
Grogl, Max
TI Topical Paromomycin with or without Gentamicin for Cutaneous
Leishmaniasis
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Article
ID PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; AMINOSIDINE PAROMOMYCIN;
OINTMENT; THERAPY
AB Background
There is a need for a simple and efficacious treatment for cutaneous leishmaniasis with an acceptable side-effect profile.
Methods
We conducted a randomized, vehicle-controlled phase 3 trial of topical treatments containing 15% paromomycin, with and without 0.5% gentamicin, for cutaneous leishmaniasis caused by Leishmania major in Tunisia. We randomly assigned 375 patients with one to five ulcerative lesions from cutaneous leishmaniasis to receive a cream containing 15% paromomycin-0.5% gentamicin (called WR 279,396), 15% paromomycin alone, or vehicle control (with the same base as the other two creams but containing neither paromomycin nor gentamicin). Each lesion was treated once daily for 20 days. The primary end point was the cure of the index lesion. Cure was defined as at least 50% reduction in the size of the index lesion by 42 days, complete reepithelialization by 98 days, and absence of relapse by the end of the trial (168 days). Any withdrawal from the trial was considered a treatment failure.
Results
The rate of cure of the index lesion was 81% (95% confidence interval [CI], 73 to 87) for paromomycin-gentamicin, 82% (95% CI, 74 to 87) for paromomycin alone, and 58% (95% CI, 50 to 67) for vehicle control (P<0.001 for each treatment group vs. the vehicle-control group). Cure of the index lesion was accompanied by cure of all other lesions except in five patients, one in each of the paromomycin groups and three in the vehicle-control group. Mild-to-moderate application-site reactions were more frequent in the paromomycin groups than in the vehicle-control group.
Conclusions
This trial provides evidence of the efficacy of paromomycin-gentamicin and paromomycin alone for ulcerative L. major disease. (Funded by the Department of the Army; ClinicalTrials.gov number, NCT00606580.)
C1 [Ben Salah, Afif; Ben Messaoud, Nathalie; Guedri, Evelyn; Zaatour, Amor; Ben Alaya, Nissaf; Bettaieb, Jihene; Gharbi, Adel; Hamida, Nabil Belhadj; Boukthir, Aicha; Chlif, Sadok; Louzir, Hechmi] Inst Pasteur Tunis, Tunis, Tunisia.
[Mokni, Mourad] Univ Hosp la Rabta, Dept Dermatol, Tunis, Tunisia.
[Abdelhamid, Kidar] Reg Hosp Gafsa, Gafsa, Tunisia.
[El Ahmadi, Zaher] Reg Directorate Hlth, Sidi Bouzid, Tunisia.
[Morizot, Gloria; Buffet, Pierre] Inst Pasteur, Paris, France.
[Buffet, Pierre] Univ Paris 06, INSERM, Unite Mixte Rech S 945, Paris, France.
[Smith, Philip L.; Kopydlowski, Karen M.; Kreishman-Deitrick, Mara; Smith, Kirsten S.; Nielsen, Carl J.; Ullman, Diane R.; Norwood, Jeanne A.; Thorne, George D.; McCarthy, William F.; Adams, Ryan C.; Rice, Robert M.] USA, Ft Detrick, MD USA.
[Tang, Douglas; Berman, Jonathan; Ransom, Janet] Fast Track Drugs & Biol, N Potomac, MD USA.
[Magill, Alan J.; Grogl, Max] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA.
RP Grogl, M (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM max.grogl@amedd.army.mil
FU Department of the Army; U.S.-French-Tunisia collaboration; U.S. Army
Medical Materiel Development Activity; Institut Pasteur, Paris; U.S.
Army Medical Research and Materiel Command; Walter Reed Army Institute
of Research
FX Supported by the Department of the Army. The investigators have adhered
to the policies for protection of human subjects as prescribed in Army
Regulation 70-25.; We thank the Regional Directorates of Health of Sidi
Bouzid, Kairouan, and Gafsa, Tunisia; Farhat Mighri, Primary Health
Center, El Mnara, Tunisia; the World Health Organization Reference
Laboratory, Montpellier, France, for characterization of all isolated
leishmania parasites; Prof. Dellagi Koussay, M. D., for his support of
the U.S.-French-Tunisia collaboration; the Institut Pasteur, Paris, for
management of the Cooperative Agreement between the U.S. Army Medical
Materiel Development Activity and the Institut Pasteur; William Ellis,
for ensuring investigational product transport and import in accordance
with current Good Manufacturing Practice guidelines; Shirley Roach and
Denise McKinney for clinical monitoring; senior leaders of the U.S. Army
Medical Materiel Development Activity, U.S. Army Medical Research and
Materiel Command, and Walter Reed Army Institute of Research for their
support; and the volunteers for their participation and the parents who
allowed their children to participate in the study.
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U1 3
U2 26
PU MASSACHUSETTS MEDICAL SOC
PI WALTHAM
PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA
SN 0028-4793
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD FEB 7
PY 2013
VL 368
IS 6
BP 524
EP 532
DI 10.1056/NEJMoa1202657
PG 9
WC Medicine, General & Internal
SC General & Internal Medicine
GA 083VU
UT WOS:000314494100003
PM 23388004
ER
PT J
AU Vento, TJ
Cole, DW
Mende, K
Calvano, TP
Rini, EA
Tully, CC
Zera, WC
Guymon, CH
Yu, X
Cheatle, KA
Akers, KS
Beckius, ML
Landrum, ML
Murray, CK
AF Vento, Todd J.
Cole, David W.
Mende, Katrin
Calvano, Tatjana P.
Rini, Elizabeth A.
Tully, Charla C.
Zera, Wendy C.
Guymon, Charles H.
Yu, Xin
Cheatle, Kristelle A.
Akers, Kevin S.
Beckius, Miriam L.
Landrum, Michael L.
Murray, Clinton K.
TI Multidrug-resistant gram-negative bacteria colonization of healthy US
military personnel in the US and Afghanistan
SO BMC INFECTIOUS DISEASES
LA English
DT Article
DE Deployment; Malaria chemoprophylaxis; Environment exposure;
ESBL-production; Escherichia coli
ID INFECTIOUS-DISEASES SOCIETY; SPECTRUM BETA-LACTAMASES; COMBAT-RELATED
INJURIES; ESCHERICHIA-COLI; FECAL FLORA; KLEBSIELLA-PNEUMONIAE;
HOSPITALIZED-PATIENTS; RISK-FACTORS; TETRACYCLINE; DOXYCYCLINE
AB Background: The US military has seen steady increases in multidrug-resistant (MDR) gram-negative bacteria (GNB) infections in casualties from Iraq and Afghanistan. This study evaluates the prevalence of MDR GNB colonization in US military personnel.
Methods: GNB colonization surveillance of healthy, asymptomatic military personnel (101 in the US and 100 in Afghanistan) was performed by swabbing 7 anatomical sites. US-based personnel had received no antibiotics within 30 days of specimen collection, and Afghanistan-based personnel were receiving doxycycline for malaria chemoprophylaxis at time of specimen collection. Isolates underwent genotypic and phenotypic characterization.
Results: The only colonizing MDR GNB recovered in both populations was Escherichia coli (p=0.01), which was seen in 2% of US-based personnel (all perirectal) and 11% of Afghanistan-based personnel (10 perirectal, 1 foot+groin). Individuals with higher off-base exposures in Afghanistan did not show a difference in overall GNB colonization or MDR E. coli colonization, compared with those with limited off-base exposures.
Conclusion: Healthy US- and Afghanistan-based military personnel have community onset-MDR E. coli colonization, with Afghanistan-based personnel showing a 5.5-fold higher prevalence. The association of doxycycline prophylaxis or other exposures with antimicrobial resistance and increased rates of MDR E. coli colonization needs further evaluation.
C1 [Vento, Todd J.; Mende, Katrin; Calvano, Tatjana P.; Rini, Elizabeth A.; Tully, Charla C.; Zera, Wendy C.; Yu, Xin; Cheatle, Kristelle A.; Akers, Kevin S.; Beckius, Miriam L.; Landrum, Michael L.; Murray, Clinton K.] San Antonio Mil Med Ctr, Brooke Army Med Ctr, Ft Sam Houston, TX USA.
[Vento, Todd J.; Akers, Kevin S.; Murray, Clinton K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Cole, David W.] Blanchfield Army Community Hosp, Ft Campbell, KY USA.
[Mende, Katrin; Zera, Wendy C.; Landrum, Michael L.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
[Guymon, Charles H.; Akers, Kevin S.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Murray, CK (reprint author), San Antonio Mil Med Ctr, Brooke Army Med Ctr, Ft Sam Houston, TX USA.
EM clinton.murray@us.army.mil
RI Valle, Ruben/A-7512-2013
FU Armed Forces Health Surveillance Center; Global Emerging Infectious
System
FX The views expressed herein are those of the authors and do not reflect
the official policy or position of the Department of the Army,
Department of the Air Force, Department of Defense, or the US
Government. The authors are employees of the US government. This work
was prepared as part of their official duties and, as such, there is no
copyright to be transferred. This work was supported by the Armed Forces
Health Surveillance Center including the Global Emerging Infectious
System.
NR 34
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U1 2
U2 7
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2334
J9 BMC INFECT DIS
JI BMC Infect. Dis.
PD FEB 5
PY 2013
VL 13
AR 68
DI 10.1186/1471-2334-13-68
PG 11
WC Infectious Diseases
SC Infectious Diseases
GA 113SL
UT WOS:000316688600001
PM 23384348
ER
PT J
AU Jiang, HB
Holtz, LR
Bauer, I
Franz, CJ
Zhao, GY
Bodhidatta, L
Shrestha, SK
Kang, G
Wang, D
AF Jiang, Hongbing
Holtz, Lori R.
Bauer, Irma
Franz, Carl J.
Zhao, Guoyan
Bodhidatta, Ladaporn
Shrestha, Sanjaya K.
Kang, Gagandeep
Wang, David
TI Comparison of novel MLB-clade, VA-clade and classic human astroviruses
highlights constrained evolution of the classic human astrovirus
nonstructural genes
SO VIROLOGY
LA English
DT Article
DE Astrovirus discovery; Diarrhea; Nonstructural genes; Constrained
evolution
ID MOLECULAR CHARACTERIZATION; MAXIMUM-LIKELIHOOD; CHILDREN;
GASTROENTERITIS; DIVERSITY; DIARRHEA
AB Eight serotypes of human astroviruses (the classic human astroviruses) are causative agents of diarrhea. Recently, five additional astroviruses belonging to two distinct clades have been described in human stool, including astroviruses MLB1, MLB2, VA1, VA2 and VA3. We report the discovery in human stool of two novel astroviruses, astroviruses MLB3 and VA4. The complete genomes of these two viruses and the previously described astroviruses VA2 and VA3 were sequenced, affording seven complete genomes from the MLB and VA clades for comparative analysis to the classic human astroviruses. Comparison of the genetic distance, number of synonymous mutations per synonymous site (dS), number of non-synonymous mutations per non-synonymous site (dN) and the dN/dS ratio in the protease, polymerase and capsid of the classic human, MLB and VA clades suggests that the protease and polymerase of the classic human astroviruses are under distinct selective pressure. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Jiang, Hongbing; Bauer, Irma; Franz, Carl J.; Zhao, Guoyan; Wang, David] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA.
[Holtz, Lori R.] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA.
[Bodhidatta, Ladaporn] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand.
[Shrestha, Sanjaya K.] Walter Reed AFRIMS Res Unit Nepal, Kathmandu, Nepal.
[Kang, Gagandeep] Christian Med Coll & Hosp, Dept Gastrointestinal Sci, Vellore, Tamil Nadu, India.
RP Wang, D (reprint author), Washington Univ, Sch Med, Dept Mol Microbiol, 660 S Euclid Ave, St Louis, MO 63110 USA.
EM davewang@borcim.wustl.edu
RI Valle, Ruben/A-7512-2013;
OI Kang, Gagandeep/0000-0002-3656-564X; Holtz, Lori/0000-0002-5591-7794
FU NIH [U54 AI057160, R21 AI090199]; Burroughs Wellcome Fund; NIH-National
Center for Advancing Translational Sciences [UL1 TR000448, KL2 TR000450]
FX This work was supported in part by NIH grant U54 AI057160 to the Midwest
Regional Center of Excellence for Biodefense and Emerging Infectious
Disease Research and NIH grant R21 AI090199. D.W. holds an Investigator
in the Pathogenesis of Infectious Disease Award from the Burroughs
Wellcome Fund. LRH is supported by UL1 TR000448 sub award KL2 TR000450
from the NIH-National Center for Advancing Translational Sciences.
NR 27
TC 25
Z9 25
U1 0
U2 5
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0042-6822
J9 VIROLOGY
JI Virology
PD FEB 5
PY 2013
VL 436
IS 1
BP 8
EP 14
DI 10.1016/j.virol.2012.09.040
PG 7
WC Virology
SC Virology
GA 077BV
UT WOS:000314003800002
PM 23084422
ER
PT J
AU La Scala, J
Wool, RP
AF La Scala, John
Wool, Richard P.
TI Fundamental thermo-mechanical property modeling of triglyceride-based
thermosetting resins
SO JOURNAL OF APPLIED POLYMER SCIENCE
LA English
DT Article
DE crosslinking; glass transition; thermosets; renewable resources;
relaxation
ID DIELECTRIC RELAXATION BEHAVIOUR; EMPIRICAL DECAY FUNCTION; FATTY-ACID
COMPOSITION; VINYL-ESTER; MECHANICAL-PROPERTIES; SEGMENTAL RELAXATION;
CURE KINETICS; POLYMERS; TEMPERATURE; NETWORKS
AB The glass transition temperature (T-g) of acrylated triglycerides was clearly a function of the level of acrylation of triglyceride-based polymers and was modeled using simple empirical relationships. We began by calculating the distribution of unsaturation sites in plant oils. We assumed a binomial distribution of chemical functionality that was added to these unsaturation sites to calculate the distribution of epoxides, acrylates, and reacted acrylates to predict the crosslink density, thermal softening, and dynamic mechanical behavior. The glass transition temperatures of n-acrylated triglycerides were used as the relaxation temperatures of acrylated oils with a broad distribution of functionality for prediction of the modulus as a function of temperature. Essentially, the percent drop in the elastic modulus is equal to the percentage of n-acrylated triglycerides in the acrylated oil with T-g less than that of the ambient temperature. The tan (delta) was also accurately predicted based on the percentage change of n-functional triglycerides as the temperature changes from one relaxation temperature to the next. (c) 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 127: 1812-1826, 2013
C1 [La Scala, John] USA, Res Lab, RDRL WMM C, Dept Army, Aberdeen Proving Ground, MD 21005 USA.
[La Scala, John; Wool, Richard P.] Univ Delaware, Dept Chem Engn, Newark, DE 19716 USA.
RP La Scala, J (reprint author), USA, Res Lab, RDRL WMM C, Dept Army, Aberdeen Proving Ground, MD 21005 USA.
EM john.j.lascala.civ@mail.mil
FU Army Research Laboratory; University of Delaware Army Materials Center
of Excellence; NSF; EPA; DoE
FX This work was supported by Army Research Laboratory, the University of
Delaware Army Materials Center of Excellence, NSF, EPA, and DoE for
funding. The authors thank DuPont for providing the genetically
engineered high oleic soybean oil and the ACRES group at the University
of Delaware for helpful discussions.
NR 39
TC 8
Z9 8
U1 2
U2 27
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-8995
J9 J APPL POLYM SCI
JI J. Appl. Polym. Sci.
PD FEB 5
PY 2013
VL 127
IS 3
BP 1812
EP 1826
DI 10.1002/app.37927
PG 15
WC Polymer Science
SC Polymer Science
GA 030XJ
UT WOS:000310603100048
ER
PT J
AU Thellen, C
Cheney, S
Ratto, JA
AF Thellen, Christopher
Cheney, Sarah
Ratto, Jo Ann
TI Melt processing and characterization of polyvinyl alcohol and
polyhydroxyalkanoate multilayer films
SO JOURNAL OF APPLIED POLYMER SCIENCE
LA English
DT Article
DE polyvinyl alcohol; polyhydroxyalkanoate; barrier; coextrusion;
multilayer films; permeation
ID BIODEGRADATION; POLY(3-HYDROXYBUTYRATE); PERMEATION
AB Multilayer films for food packaging applications composed of polyvinyl alcohol (PVOH) as the core layer and polyhydroxyalkanoate (PHA) as the outer skin layers were produced by the co-extrusion process. Rheological properties of PVOH and PHA were performed and analyzed before co-extruding into a cast film. Analysis of the rheological data indicated the processing temperatures and grades of the PVOH and PHA polymers that would produce similar viscosity and melt flow properties. To improve adhesion of the layers, PHA was grafted with maleic anhydride using a dicumyl peroxide initiator to provide a tie layer material, which improved the peel strength of the PHA and PVOH layers by over 2x. Oxygen transmission rate (OTR) testing showed that the multilayer sample provided an OTR of 27 cc/m(2)-day at 0% relative humidity (RH) and rates of 41 and 52 cc/m(2)-day at relative humidity values of 60% and 90% RH, respectively. This indicates significant barrier performance enhancement over monolayer PVOH that provided an OTR of 60 cc/m(2)-day at 0% RH and 999 cc/m(2)-day at 60% RH. Biodegradation testing of the films in the marine environment showed that both the unmodified and maleated PHA polymers displayed high levels of mineralization, whereas the PVOH material did not. (c) 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
C1 [Thellen, Christopher; Cheney, Sarah; Ratto, Jo Ann] USA, Combat Feeding Directorate, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA.
RP Thellen, C (reprint author), USA, Combat Feeding Directorate, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA.
EM christopher.t.thellen.civ@mail.mil
FU U.S. Navy Waste Reduction Afloat Protects the Sea (WRAPS) program
FX The authors thank the U.S. Navy Waste Reduction Afloat Protects the Sea
(WRAPS) program, especially Mr. Jeff Whitman, Mr. John Bendick, and Mr.
Trey Kunkel, for funding the research discussed in this article. A
special acknowledgement goes to Dr. Robert Whitehouse of Metabolix Inc.,
Professor Daniel Schmidt, and Professor Stephen McCarthy of the
University of Massachusetts Lowell for working with the NSRDEC on this
project and supplying their knowledge and expertise in the area of PHA
polymers. Heather Scaglione of A. Schulman, Ken Kumaki of Kuraray, and
Terrence Cooper are also acknowledged for providing PVOH sample
materials along with their experience in the area of PVOH films and
processing. They also thank Dr. Joel Carlson and Ms. Diane Steeves for
their FTIR and NMR expertise, as well as Ms. Danielle Froio, Mr. Matthew
Bernasconi, Mr. Christopher Hope, and Ms. Jeanne Lucciarini of the
NSRDEC for all of their efforts in relation to this research. This
research could not have been accomplished without their efforts.
NR 40
TC 9
Z9 9
U1 5
U2 61
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-8995
J9 J APPL POLYM SCI
JI J. Appl. Polym. Sci.
PD FEB 5
PY 2013
VL 127
IS 3
BP 2314
EP 2324
DI 10.1002/app.37850
PG 11
WC Polymer Science
SC Polymer Science
GA 030XJ
UT WOS:000310603100106
ER
PT J
AU Shoop, SA
Sandu, C
Ayers, P
AF Shoop, Sally A.
Sandu, Corina
Ayers, Paul
TI Introduction: Best papers from the 50th Anniversary ISTVS Conference
SO JOURNAL OF TERRAMECHANICS
LA English
DT Editorial Material
C1 [Shoop, Sally A.] Erdc, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
[Sandu, Corina] Virginia Tech, Blacksburg, VA USA.
[Ayers, Paul] Univ Tennessee, Knoxville, TN USA.
RP Shoop, SA (reprint author), Erdc, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA.
EM Sally.a.shoop@usace.army.mil; csandu@vt.edu; ayers@utk.edu
NR 10
TC 0
Z9 0
U1 0
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4898
J9 J TERRAMECHANICS
JI J. Terramech.
PD FEB
PY 2013
VL 50
IS 1
SI SI
BP 3
EP 4
DI 10.1016/j.jterra.2013.03.002
PG 2
WC Engineering, Environmental
SC Engineering
GA 146LL
UT WOS:000319092500001
ER
PT J
AU Shoop, S
Knuth, M
Wieder, W
AF Shoop, S.
Knuth, M.
Wieder, W.
TI Measuring vehicle impacts on snow roads
SO JOURNAL OF TERRAMECHANICS
LA English
DT Article
DE Strength; Disturbance; Rut; Rammsonde; Clegg; Maneuver; Turning; Corner;
Speed
AB The snow roads at McMurdo Station are the primary transport corridors to move personnel and material from the airfields servicing intra- and inter-continental air traffic for resupply. Thus, they are a critical transportation component and are particularly susceptible to deterioration during the warmest parts of the austral summer when above-freezing temperatures can occur for several days at a time. This study served to explore methodology that could quantify the impact of various vehicles, tires, driving speeds and maneuvers on the snow road conditions. Basic maneuvers were used to isolate the impact of turning, acceleration, braking and speed using spirals, circles, and straight-line testing on a flat, smooth snow pavement. In addition, a road course was set up to include corners and roughness using portions of the active snow roads for more realistic conditions. Measurements included snow surface strength both in and between tire tracks, tire track rut depth and width, and the height and width of the resulting snow piles adjacent to the tire tracks. Results indicate the impacts of driving speed and vehicle type including the importance of the tire and suspension components for preserving the road surfaces through the melt season. Since this type of testing had not been done on snow before, or using these vehicle types, the experiments yielded valuable guidance regarding what types of maneuvers, test surfaces, and measurements could most easily differentiate performance. Published by Elsevier Ltd. on behalf of ISTVS.
C1 [Shoop, S.; Knuth, M.] USA, Cold Reg Res & Engn Lab, Engn Res & Dev Ctr, Hanover, NH 03755 USA.
[Wieder, W.] Sci & Technol Corp, Hampton, VA 23666 USA.
RP Shoop, S (reprint author), USA, Cold Reg Res & Engn Lab, Engn Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA.
EM Sally.a.shoop@usace.army.mil
FU National Science Foundation Office of Polar Programs; CRREL; Fleet
Operations Ice Shelf Crew; Shuttle Transportation Crew of Raytheon Polar
Service Corp.
FX The authors thanks the following personnel for their extra efforts and
assistance with the funding, preparations, testing and measurements: Mr.
George Blaisdell of the National Science Foundation Office of Polar
Programs; Ms. Rosa Affleck of CRREL; Mr. Christopher Tomac, Mr. Alan
Shaw, Ms. Julia Uberuaga, and Mr. William Sundee, from the Fleet
Operations Ice Shelf Crew and the Shuttle Transportation Crew of
Raytheon Polar Service Corp.
NR 12
TC 2
Z9 2
U1 1
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4898
J9 J TERRAMECHANICS
JI J. Terramech.
PD FEB
PY 2013
VL 50
IS 1
SI SI
BP 63
EP 71
DI 10.1016/j.jterra.2013.01.004
PG 9
WC Engineering, Environmental
SC Engineering
GA 146LL
UT WOS:000319092500007
ER
PT J
AU Newman, RA
Kamimori, GH
Wesensten, NJ
Picchioni, D
Balkin, TJ
AF Newman, Rachel A.
Kamimori, Gary H.
Wesensten, Nancy J.
Picchioni, Dante
Balkin, Thomas J.
TI CAFFEINE GUM MINIMIZES SLEEP INERTIA
SO PERCEPTUAL AND MOTOR SKILLS
LA English
DT Article
ID HUMAN-PERFORMANCE; ALERTNESS; ADENOSINE; VIGILANCE; RESTRICTION;
DEPRIVATION; DISRUPTION; AWAKENINGS; OPERATIONS; PLACEMENT
AB Naps are an effective strategy for maintaining alertness and cognitive performance; however, upon abrupt wakening from naps, sleep inertia (temporary performance degradation) may ensue. In the present study, attenuation of post-nap sleep inertia was attempted by administration of caffeine gum. Using a double-blind, placebo-controlled crossover design, 15 healthy, non-smoking adults were awakened at 1 hr. and again at 6 hr. after lights out (0100 and 0600, respectively) and were immediately administered a gum pellet containing 100 mg of caffeine or placebo. A 5-min. psychomotor vigilance task was administered at 0 min., 6 min., 12 min., and 18 min. post-awakening. At 0100, response speed with caffeine was significantly better at 12 min. and 18 min. post-awakening compared to placebo; at 0600, caffeine's effects were evident at 18 min. post-awakening. Caffeinated gum is a viable means of rapidly attenuating sleep inertia, suggesting that the adenosine receptor system is involved in sleep maintenance.
C1 [Newman, Rachel A.; Kamimori, Gary H.; Wesensten, Nancy J.; Picchioni, Dante; Balkin, Thomas J.] Walter Reed Army Inst Res, Dept Behav Biol, Ctr Mil Psychiat & Neurosci Res, Silver Spring, MD USA.
RP Newman, RA (reprint author), WRAIR 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM Rachel.Newman@us.army.mil
NR 32
TC 9
Z9 9
U1 3
U2 12
PU AMMONS SCIENTIFIC, LTD
PI MISSOULA
PA PO BOX 9229, MISSOULA, MT 59807-9229 USA
SN 0031-5125
J9 PERCEPT MOTOR SKILL
JI Percept. Mot. Skills
PD FEB
PY 2013
VL 116
IS 1
BP 280
EP 293
DI 10.2466/29.22.25.PMS.116.1.280-293
PG 14
WC Psychology, Experimental
SC Psychology
GA 142IS
UT WOS:000318791400026
PM 23829154
ER
PT J
AU Chang, MP
Fok, M
Hofmaier, A
Prucnal, PR
AF Chang, Matthew P.
Fok, Mable
Hofmaier, Andrew
Prucnal, Paul R.
TI Optical Analog Self-Interference Cancellation Using Electro-Absorption
Modulators
SO IEEE MICROWAVE AND WIRELESS COMPONENTS LETTERS
LA English
DT Article
DE Electro-absorption modulators (EAMs); microwave photonics;
self-interference cancellation (SIC)
AB An optical analog self-interference cancellation system for radio-frequency communications is proposed and experimentally demonstrated. The system uses two electro-absorption modulators, an optical attenuator and delay, and a balanced photodetector to subtract strong self-interference from a corrupted received signal and recover a weak signal of interest. The system achieves > 65 dB narrowband cancellation and > 30 dB broadband cancellation across more than 40 MHz bandwidth for interference in both the 900 MHz and 2.4GHz bands. Both narrowband and broadband cancellation are frequency tunable, and can be combined with other forms of interference cancellation to achieve even higher levels of cancellation.
C1 [Chang, Matthew P.; Prucnal, Paul R.] Princeton Univ, Dept Elect Engn, Princeton, NJ 08544 USA.
[Fok, Mable] Univ Georgia, Coll Engn, Athens, GA 30602 USA.
[Hofmaier, Andrew] USA, CERDEC, Aberdeen Proving Ground, MD 21005 USA.
RP Chang, MP (reprint author), Princeton Univ, Dept Elect Engn, Princeton, NJ 08544 USA.
EM mpchang@princeton.edu; mfok@uga.edu; andrew.p.hofmaier.civ@mail.mil
FU National Security Agency
FX This work was supported in part by the National Security Agency.
NR 9
TC 19
Z9 19
U1 0
U2 7
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1531-1309
J9 IEEE MICROW WIREL CO
JI IEEE Microw. Wirel. Compon. Lett.
PD FEB
PY 2013
VL 23
IS 2
BP 99
EP 101
DI 10.1109/LMWC.2013.2240288
PG 3
WC Engineering, Electrical & Electronic
SC Engineering
GA 138IE
UT WOS:000318501400015
ER
PT J
AU Lee, BB
Baumgartner, I
Berlien, HP
Bianchini, G
Burrows, P
Do, YS
Ivancev, K
Kool, LS
Laredo, J
Loose, DA
Lopez-Gutierrez, JC
Mattassi, R
Parsi, K
Rimon, U
Rosenblatt, M
Shortell, C
Simkin, R
Stillo, F
Villavicencio, L
Yakes, W
AF Lee, B. B.
Baumgartner, I.
Berlien, H. P.
Bianchini, G.
Burrows, P.
Do, Y. S.
Ivancev, K.
Kool, L. S.
Laredo, J.
Loose, D. A.
Lopez-Gutierrez, J. C.
Mattassi, R.
Parsi, K.
Rimon, U.
Rosenblatt, M.
Shortell, C.
Simkin, R.
Stillo, F.
Villavicencio, L.
Yakes, W.
TI Consensus Document of the International Union of Angiology (IUA)-2013
Current concepts on the management of arterio-venous malformations
SO INTERNATIONAL ANGIOLOGY
LA English
DT Article
DE Arteriovenous malformations; Central nervous system vascular
malformations; Classffication; Angiography; Sclerotherapy
ID CONGENITAL VASCULAR MALFORMATIONS; HEREDITARY HEMORRHAGIC
TELANGIECTASIA; N-BUTYL CYANOACRYLATE; PULMONARY ARTERIAL-PRESSURE;
SINGLE-CENTER EXPERIENCE; BLOOD-POOL SCINTIGRAPHY; FOLLOW-UP ASSESSMENT;
PORT-WINE STAINS; VENOUS MALFORMATIONS; SOFT-TISSUE
AB Arterio-venous malformations (AVMs) are congenital vascular malformations (CVMs) that result from birth defects involving the vessels of both arterial and venous origins, resulting in direct communications between the different size vessels or a meshwork of primitive reticular networks of dysplastic minute vessels which have failed to mature to become 'capillary' vessels termed "nidus". These lesions are defined by shunting of high velocity, low resistance flow from the arterial vasculature into the venous system in a variety of fistulous conditions. A systematic classification system developed by various groups of experts (Hamburg classification, ISSVA classification, Schobinger classification, angiographic classification of AVMs,) has resulted in a better understanding of the biology and natural history of these lesions and improved management of CVMs and AVMs. The Hamburg classification, based on the embryological differentiation between extratruncular and truncular type of lesions, allows the determination of the potential of progression and recurrence of these lesions. The majority of all AVMs are extra-truncular lesions with persistent proliferative potential, whereas truncular AVM lesions are exceedingly rare. Regardless of the type, AV shunting may ultimately result in significant anatomical, pathophysiological and hemodynamic consequences. Therefore, despite their relative rarity (10-20% of all CVMs), AVMs remain the most challenging and potentially limb or life-threatening form of vascular anomalies. The initial diagnosis and assessment may be facilitated by non- to minimally invasive investigations such as duplex ultrasound, magnetic resonance imaging (MRI), MR angiography (MRA), computerized tomography (CT) and CT angiography (CTA). Arteriography remains the diagnostic gold standard, and is required for planning subsequent treatment. A multidisciplinary team approach should be utilized to integrate surgical and non-surgical interventions for optimum care. Currently available treatments are associated with significant risk of complications and morbidity. However, an early aggressive approach to elimiate the nidus (if present) may be undertaken if the benefits exceed the risks. Trans-arterial coil embolization or ligation of feeding arteries where the nidus is left intact, are incorrect approaches and may result in proliferation of the lesion. Furthermore, such procedures would prevent future endovascular access to the lesions via the arterial route. Surgically inaccessible, infiltrating, extra-truncular AVMs can be treated with endovascular therapy as an independent modality. Among various embolo-sclerotherapy agents, ethanol sclerotherapy produces the best long term outcomes with minimum recurrence. However, this procedure requires extensive training and sufficient experience to minimize complications and associated morbidity For the surgically accessible lesions, surgical resection may be the treatment of choice with a chance of optimal control. Preoperative sclerotherapy or embolization may supplement the subsequent surgical excision by reducing the morbidity (e.g. operative bleeding) and defining the lesion borders. Such a combined approach may provide an excellent potential for a curative result.
Conclusion. AVMs are high flow congenital vascular malformations that may occur in any part of the body. The clinical presentation depends on the extent and size of the lesion and can range from an asymptomatic birthmark to congestive heart failure. Detailed investigations including duplex ultrasound, MRI/MRA and CT/CTA are required to develop an appropriate treatment plan. Appropriate management is best achieved via a multi-disciplinary approach and interventions should be undertaken by appropriately trained physicians. [Int Angiol 2013;32:9-36]
C1 [Lee, B. B.] George Washington Univ, Div Vasc Surg, Dept Surg, Ctr Vasc Malformat & Lymphedema,Sch Med, Washington, DC 20037 USA.
[Baumgartner, I.] Univ Hosp Bern, Dept Internal Med Director Clin & Intervent Angio, Swiss Cardiovasc Ctr, CH-3010 Bern, Switzerland.
[Berlien, H. P.] Evangel Elisabeth Klin, Dept Laser Med, Berlin, Germany.
[Bianchini, G.] IDI Hosp, Div Vasc Surg, Ctr Vasc Anomalies, Rome, Italy.
[Burrows, P.] Med Coll Wisconsin, Childrens Hosp Wisconsin, Dept Radiol, Milwaukee, WI 53226 USA.
[Do, Y. S.] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Seoul, South Korea.
[Do, Y. S.] Sungkyunkwan Univ, Sch Med, Seoul, South Korea.
[Ivancev, K.] Royal Free Hosp, Dept Intervent Radiol, Complex EVAR Programme, London NW3 2QG, England.
[Kool, L. S.] Radboud Univ Nijmegen, Dept Intervent Radiol, Med Ctr, NL-6525 ED Nijmegen, Netherlands.
[Laredo, J.] George Washington Univ, Div Vasc Surg, Dept Surg, Ctr Vein Lymphat & Vasc Malformat,Sch Med, Washington, DC 20037 USA.
[Loose, D. A.] Die Facharztklin Hamburg, Dept Vasc Surg, European Ctr Diag & Treatment Vasc Malformat, Hamburg, Germany.
[Lopez-Gutierrez, J. C.] La Paz Children Hosp, Vasc Anomalies Ctr, Dept Surg, Madrid, Spain.
[Mattassi, R.] Clin Inst Humanitas Mater Domini, Dept Vasc Surg, Ctr Vasc Malformat Stefan Belov, Castellanza, Varese, Italy.
[Parsi, K.] Univ New S Wales, Dept Dermatol, St Vincents Hosp, Sydney, NSW, Australia.
[Rimon, U.] Tel Aviv Univ, Sackler Sch Med, Dept Intervent Radiol, Sheba Med Ctr, IL-69978 Tel Aviv, Israel.
[Rosenblatt, M.] Connecticut Image Guided Surg, Fairfield, CT USA.
[Shortell, C.] Duke Univ, Med Ctr, Dept Surg, Div Vasc Surg, Durham, NC 27710 USA.
[Shortell, C.] Duke Univ, Med Ctr, Dept Surg, Fac Affairs, Durham, NC 27710 USA.
[Simkin, R.] Univ Buenos Aires, Fac Med, Dept Surg, Buenos Aires, DF, Argentina.
[Stillo, F.] IDI Hosp, Dept Vasc Surg, Ctr Vasc Anomalies, Rome, Italy.
[Villavicencio, L.] Uniformed Serv Univ Hlth Sci, Dept Surg, Sch Med, Walter Reed Army Med Ctr, Bethesda, MD USA.
[Yakes, W.] Univ Colorado, Hlth Sci Ctr, Vasc Malformat Ctr, Englewood, CO USA.
RP Lee, BB (reprint author), George Washington Univ, Div Vasc Surg, Dept Surg, Med Ctr, 22nd & 1 St,NW,6th Floor, Washington, DC 20037 USA.
EM bblee@mfa.gwu.edu
NR 228
TC 26
Z9 29
U1 0
U2 10
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0392-9590
J9 INT ANGIOL
JI Int. Angiol.
PD FEB
PY 2013
VL 32
IS 1
BP 9
EP 36
PG 28
WC Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 135CI
UT WOS:000318263200002
PM 23435389
ER
PT J
AU Berry, JS
Trappey, AF
Vreeland, T
Clifton, G
Sears, A
Clive, K
Ferrise, S
Saenger, JS
Kirkpatrick, AD
Lallemand, M
Peoples, GE
AF Berry, J. S.
Trappey, A. F.
Vreeland, T.
Clifton, G.
Sears, A.
Clive, K.
Ferrise, S.
Saenger, J. S.
Kirkpatrick, A. D.
Lallemand, M.
Peoples, G. E.
TI Pure Flat Epithelial Atypia (PFEA): Excise or Observe
SO ANNALS OF SURGICAL ONCOLOGY
LA English
DT Meeting Abstract
CT 66th Annual Cancer Symposium of the Society-of-Surgical-Oncology (SSO)
CY MAR 06-09, 2013
CL National Harbor, MD
SP Soc Surg Oncol (SSO)
C1 [Berry, J. S.; Trappey, A. F.; Vreeland, T.; Sears, A.; Clive, K.; Ferrise, S.; Saenger, J. S.; Kirkpatrick, A. D.; Peoples, G. E.] Brooke Army Med Ctr, San Antonio, TX USA.
[Clifton, G.] Blanchfield Army Community Hosp, Ft Campbell, KY USA.
[Lallemand, M.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1068-9265
J9 ANN SURG ONCOL
JI Ann. Surg. Oncol.
PD FEB
PY 2013
VL 20
SU 1
BP S45
EP S46
PG 2
WC Oncology; Surgery
SC Oncology; Surgery
GA 133XR
UT WOS:000318174700115
ER
PT J
AU Trappey, AF
Berry, J
Vreeland, T
Hale, D
Sears, A
Dabney, RS
Ponniah, S
Perez, SA
Clifton, GT
Hintz, C
Covelli, JD
Papamichail, M
Peoples, GE
Mittendorf, EA
AF Trappey, A. F.
Berry, J.
Vreeland, T.
Hale, D.
Sears, A.
Dabney, R. S.
Ponniah, S.
Perez, S. A.
Clifton, G. T.
Hintz, C.
Covelli, J. D.
Papamichail, M.
Peoples, G. E.
Mittendorf, E. A.
TI Factors Associated with Recurrence in Breast Cancer Patients Vaccinated
with the HER2-Derived GP2 Vaccine
SO ANNALS OF SURGICAL ONCOLOGY
LA English
DT Meeting Abstract
CT 66th Annual Cancer Symposium of the Society-of-Surgical-Oncology (SSO)
CY MAR 06-09, 2013
CL National Harbor, MD
SP Soc Surg Oncol (SSO)
C1 [Trappey, A. F.; Berry, J.; Vreeland, T.; Hale, D.; Sears, A.; Dabney, R. S.; Clifton, G. T.; Peoples, G. E.] Brooke Army Med Ctr, San Antonio, TX USA.
[Ponniah, S.; Hintz, C.; Covelli, J. D.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Perez, S. A.; Papamichail, M.] St Savas Canc Hosp, Canc Immunol & Immunotherapy Ctr, Athens, Greece.
[Mittendorf, E. A.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1068-9265
J9 ANN SURG ONCOL
JI Ann. Surg. Oncol.
PD FEB
PY 2013
VL 20
SU 1
BP S59
EP S59
PG 1
WC Oncology; Surgery
SC Oncology; Surgery
GA 133XR
UT WOS:000318174700155
ER
PT J
AU Vreeland, TJ
Berry, JS
Trappey, AF
Hale, D
Clifton, GT
Sears, A
Shumway, NM
Holmes, JP
Ponniah, S
Mittendorf, EA
Ioannides, CG
Peoples, GE
AF Vreeland, T. J.
Berry, J. S.
Trappey, A. F.
Hale, D.
Clifton, G. T.
Sears, A.
Shumway, N. M.
Holmes, J. P.
Ponniah, S.
Mittendorf, E. A.
Ioannides, C. G.
Peoples, G. E.
TI Use of an Attenuated Version of a Strongly Immunogenic, Peptide-based
Vaccine to Enhance an Anti-cancer Immune Response against Folate
Receptor-alpha (FR alpha)
SO ANNALS OF SURGICAL ONCOLOGY
LA English
DT Meeting Abstract
CT 66th Annual Cancer Symposium of the Society-of-Surgical-Oncology (SSO)
CY MAR 06-09, 2013
CL National Harbor, MD
SP Soc Surg Oncol (SSO)
C1 [Vreeland, T. J.; Berry, J. S.; Trappey, A. F.; Hale, D.; Clifton, G. T.; Sears, A.; Shumway, N. M.; Peoples, G. E.] Brooke Army Med Ctr, San Antonio, TX USA.
[Mittendorf, E. A.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
[Ponniah, S.; Ioannides, C. G.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Holmes, J. P.] USN, Dept Hematol & Med Oncol, San Diego Med Ctr, San Diego, CA 92152 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1068-9265
J9 ANN SURG ONCOL
JI Ann. Surg. Oncol.
PD FEB
PY 2013
VL 20
SU 1
BP S59
EP S59
PG 1
WC Oncology; Surgery
SC Oncology; Surgery
GA 133XR
UT WOS:000318174700156
ER
PT J
AU Niu, N
Yang, FB
Cheng, JRC
Reddivari, S
AF Niu, Nan
Yang, Fangbo
Cheng, Jing-Ru C.
Reddivari, Sandeep
TI Conflict resolution support for parallel software development
SO IET SOFTWARE
LA English
DT Article
ID CONFIGURATION MANAGEMENT
AB Parallel changes, in which separate lines of development are carried out by different developments, are a basic fact of developing and maintaining large-scale software systems. Merging parallel versions and variants of source code is a common and essential software engineering activity. When a non-trivial number of conflicts is detected, there is a need to support the maintainer in investigating and resolving these conflicts. In this study, the authors present software conflict resolution recommender (scoreRec), a cost-benefit approach to ranking the conflicting software entities. The contributions of scoreRec lie in the leverage of both structural and semantic information of the source code to generate conflict resolution recommendations, as well as the hierarchical presentation of the recommendations with detailed explanations. The authors evaluate scoreRec through an industrial-strength legacy system developed by computational scientists. The results show that scoreRec offers relevant and insightful information and sound engineering support for conflict resolution. The authors' work also sheds light on the future development of recommendation systems in the context of software merging.
C1 [Niu, Nan; Yang, Fangbo; Reddivari, Sandeep] Mississippi State Univ, Dept Comp Sci & Engn, Mississippi State, MS 39762 USA.
[Cheng, Jing-Ru C.] USA, Informat Technol Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Niu, N (reprint author), Mississippi State Univ, Dept Comp Sci & Engn, POB 9637, Mississippi State, MS 39762 USA.
EM niu@cse.msstate.edu
FU US Army Engineer Research & Development Center [W912HZ-10-C-0101]
FX The work is supported by the US Army Engineer Research & Development
Center (Award W912HZ-10-C-0101). Any opinions, findings, and conclusions
expressed herein are the authors' and do not necessarily reflect those
of the sponsor.
NR 33
TC 2
Z9 2
U1 0
U2 4
PU INST ENGINEERING TECHNOLOGY-IET
PI HERTFORD
PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND
SN 1751-8806
EI 1751-8814
J9 IET SOFTW
JI IET Softw.
PD FEB
PY 2013
VL 7
IS 1
BP 1
EP 11
DI 10.1049/iet-sen.2012.0089
PG 11
WC Computer Science, Software Engineering
SC Computer Science
GA 134QZ
UT WOS:000318230600001
ER
PT J
AU Linkov, I
Bates, ME
Trump, BD
Seager, TP
Chappell, MA
Keisler, JM
AF Linkov, Igor
Bates, Matthew E.
Trump, Benjamin D.
Seager, Thomas P.
Chappell, Mark A.
Keisler, Jeffrey M.
TI For nanotechnology decisions, use decision analysis
SO NANO TODAY
LA English
DT Article
DE Risk; Decision analysis; Health and safety; Green nano manufacturing
ID NANOMATERIALS
AB Management of nanotechnology is rife with complicated, contentious, and risky decisions. These decisions involve significant uncertainty, multiple stakeholder groups, competing objectives, and dynamic, non-linear interdependencies which test the limits of unaided human judgment. In the past, formal methods of risk analysis have been used to evaluate new technologies, but these methods ignore decision-relevant qualitative information and rely on a volume of quantitative engineering and scientific data that simply does not exist for many nanomaterials. Yet, we know that robust production decisions need to be holistic and based on all available information if we are to minimize negative externalities to society, human health, and the environment. We discuss how the use of decision analytical methods such as Multi-Criteria Decision Analysis and value of information analysis can help to fill existing gaps in nanomaterial risk management to make the best use of all available qualitative and quantitative information and prioritize future research based on expected decision relevance. This will help nanoparticle scientists and manufacturers to better develop and identify optimal materials and production methods in the midst of high uncertainty. Published by Elsevier Ltd.
C1 [Linkov, Igor; Bates, Matthew E.; Chappell, Mark A.] USA, Corps Engineers, Engn Res & Dev Ctr, Concord, MA 01742 USA.
[Trump, Benjamin D.] Univ Michigan, Hlth Management & Policy Program, Ann Arbor, MI 48109 USA.
[Seager, Thomas P.] Arizona State Univ, Sch Sustainable Engn & Built Environm, Tempe, AZ 85287 USA.
[Keisler, Jeffrey M.] Univ Massachusetts, Boston, MA 02125 USA.
RP Linkov, I (reprint author), USA, Corps Engineers, Engn Res & Dev Ctr, Environm Lab, 696 Virginia Rd, Concord, MA 01742 USA.
EM Igor.Linkov@usace.army.mil
NR 24
TC 5
Z9 7
U1 3
U2 34
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-0132
J9 NANO TODAY
JI Nano Today
PD FEB
PY 2013
VL 8
IS 1
BP 5
EP 10
DI 10.1016/j.nantod.2012.10.002
PG 6
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
Science, Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA 132EL
UT WOS:000318050600004
ER
PT J
AU Shakarian, P
Roos, P
Moores, G
AF Shakarian, Paulo
Roos, Patrick
Moores, Geoffrey
TI A novel analytical method for evolutionary graph theory problems
SO BIOSYSTEMS
LA English
DT Article
DE Evolutionary dynamics; Moran process; Complex networks
ID DYNAMICS; NETWORKS; GAME
AB Evolutionary graph theory studies the evolutionary dynamics of populations structured on graphs. A central problem is determining the probability that a small number of mutants overtake a population. Currently, Monte Carlo simulations are used for estimating such fixation probabilities on general directed graphs, since no good analytical methods exist. In this paper, we introduce a novel deterministic framework for computing fixation probabilities for strongly connected, directed, weighted evolutionary graphs under neutral drift. We show how this framework can also be used to calculate the expected number of mutants at a given time step (even if we relax the assumption that the graph is strongly connected), how it can extend to other related models (e.g. voter model), how our framework can provide non-trivial bounds for fixation probability in the case of an advantageous mutant, and how it can be used to find a non-trivial lower bound on the mean time to fixation. We provide various experimental results determining fixation probabilities and expected number of mutants on different graphs. Among these, we show that our method consistently outperforms Monte Carlo simulations in speed by several orders of magnitude. Finally we show how our approach can provide insight into synaptic competition in neurology. Published by Elsevier Ireland Ltd.
C1 [Shakarian, Paulo; Moores, Geoffrey] US Mil Acad, Network Sci Ctr, West Point, NY 10996 USA.
[Shakarian, Paulo; Moores, Geoffrey] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA.
[Roos, Patrick] Univ Maryland, Dept Comp Sci, College Pk, MD 20740 USA.
RP Shakarian, P (reprint author), US Mil Acad, Network Sci Ctr, West Point, NY 10996 USA.
EM paulo@shakarian.net
FU ARO [611102B74F, 2GDATXR042]; OSD [F1AF262025G01]; ONR [W911NF0810144]
FX P.S. is supported by ARO projects 611102B74F and 2GDATXR042 as well as
OSD project F1AF262025G01. P.R. is supported by ONR grant W911NF0810144.
P.S. would like to thank Stephen Turney (Harvard University) for several
discussions concerning his work. The opinions in this paper are those of
the authors and do not necessarily reflect the opinions of the funders,
the U.S. Military Academy, the U.S. Army, or the U.S. Navy.
NR 27
TC 5
Z9 5
U1 0
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0303-2647
J9 BIOSYSTEMS
JI Biosystems
PD FEB
PY 2013
VL 111
IS 2
BP 136
EP 144
DI 10.1016/j.biosystems.2013.01.006
PG 9
WC Biology; Mathematical & Computational Biology
SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational
Biology
GA 121OP
UT WOS:000317254400007
PM 23353025
ER
PT J
AU Smits, KM
Sakaki, T
Howington, SE
Peters, JF
Illangasekare, TH
AF Smits, Kathleen M.
Sakaki, Toshihiro
Howington, Stacy E.
Peters, John F.
Illangasekare, Tissa H.
TI Temperature Dependence of Thermal Properties of Sands across a Wide
Range of Temperatures (30-70 degrees C)
SO VADOSE ZONE JOURNAL
LA English
DT Article
ID REDUCED AIR-PRESSURE; WATER-CONTENT; POROUS-MEDIA; CONDUCTIVITY MODEL;
SOIL; HEAT; MOISTURE; DENSITY; ENHANCEMENT; DIFFUSIVITY
AB Due to the dynamic nature of the shallow subsurface, knowledge of soil thermal properties across a wide range of soil moisture and temperature conditions is necessary to accurately describe heat transport in many settings. Soil thermal properties are difficult to measure at high temperatures, however, due to the lack of suitable measurement devices and the potential for measurement-induced changes. Therefore, thermal property data are often scarce and incomplete and very often limited to specific soils. Due to this scarcity of accurate experimental data, empirical relationships often do not accurately predict the thermal properties of soils as a function of both soil moisture and temperature. In this study, thermal conductivity and diffusivity were measured for silica sands under loose and tight packing conditions and a field sand under varied water saturation and temperature. Several recent sensor-based technologies were integrated into a small cell modified to have a network of sampling ports, continuously monitoring water saturation, temperature, and soil thermal properties. For the test sands studied, data showed that the thermal conductivity and diffusivity increased noticeably for sample temperatures >50 degrees C. At sample temperatures between 30 and 50 degrees C, any change in thermal properties with temperature was small. Thermal conductivities measured in this study were compared with independent estimates made using empirical models from the literature. In general, good agreement was observed for most thermal conductivity data when proper fitting parameters were established, except at intermediate saturation values.
C1 [Smits, Kathleen M.; Sakaki, Toshihiro; Illangasekare, Tissa H.] Colorado Sch Mines, Ctr Expt Study Subsurface Environm Proc CESEP, Dep Civil & Environm Engn, Golden, CO 80401 USA.
[Howington, Stacy E.; Peters, John F.] USA, Corps Engineers, Ctr Res & Dev, Vicksburg, MS 39180 USA.
RP Smits, KM (reprint author), Colorado Sch Mines, Ctr Expt Study Subsurface Environm Proc CESEP, Dep Civil & Environm Engn, Golden, CO 80401 USA.
EM ksmits@mines.edu
RI Smits, Kathleen/F-8465-2014
NR 43
TC 18
Z9 18
U1 2
U2 21
PU SOIL SCI SOC AMER
PI MADISON
PA 677 SOUTH SEGOE ROAD, MADISON, WI 53711 USA
SN 1539-1663
J9 VADOSE ZONE J
JI Vadose Zone J.
PD FEB
PY 2013
VL 12
IS 1
DI 10.2136/vzj2012.0033
PG 8
WC Environmental Sciences; Soil Science; Water Resources
SC Environmental Sciences & Ecology; Agriculture; Water Resources
GA 127QK
UT WOS:000317713300009
ER
PT J
AU Stevens, GD
AF Stevens, Geoffrey D.
TI Controlling Munitions Stockpiles: How to Stop the Inadvertent Arming of
Insurgencies
SO GLOBAL POLICY
LA English
DT Article
C1 USA, Pacifics Asia Pacific Counter IED Fus Ctr, Ft Shafter, HI USA.
RP Stevens, GD (reprint author), USA, Pacifics Asia Pacific Counter IED Fus Ctr, Ft Shafter, HI USA.
NR 15
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1758-5880
J9 GLOB POLICY
JI Glob. Policy
PD FEB
PY 2013
VL 4
IS 1
BP 118
EP 121
DI 10.1111/j.1758-5899.2012.00189.x
PG 4
WC International Relations; Political Science
SC International Relations; Government & Law
GA 116WN
UT WOS:000316914100018
ER
PT J
AU Holcomb, JB
del Junco, DJ
Fox, EE
Wade, CE
Cohen, MJ
Schreiber, MA
Alarcon, LH
Bai, Y
Brasel, KJ
Bulger, EM
Cotton, BA
Matijevic, N
Muskat, P
Myers, JG
Phelan, HA
White, CE
Zhang, JJ
Rahbar, MH
AF Holcomb, John B.
del Junco, Deborah J.
Fox, Erin E.
Wade, Charles E.
Cohen, Mitchell J.
Schreiber, Martin A.
Alarcon, Louis H.
Bai, Yu
Brasel, Karen J.
Bulger, Eileen M.
Cotton, Bryan A.
Matijevic, Nena
Muskat, Peter
Myers, John G.
Phelan, Herb A.
White, Christopher E.
Zhang, Jiajie
Rahbar, Mohammad H.
CA PROMMTT Study Grp
TI The Prospective, Observational, Multicenter, Major Trauma Transfusion
(PROMMTT) Study Comparative Effectiveness of a Time-Varying Treatment
With Competing Risks
SO JAMA SURGERY
LA English
DT Article
ID DAMAGE CONTROL RESUSCITATION; FRESH-FROZEN PLASMA; RED-BLOOD-CELL;
REQUIRING MASSIVE TRANSFUSION; LIFE-THREATENING HEMORRHAGE; IMPROVED
SURVIVAL; HEMOSTATIC RESUSCITATION; EMERGENCY-DEPARTMENT; CONTROL
LAPAROTOMY; COMBAT CASUALTIES
AB Objective: To relate in-hospital mortality to early transfusion of plasma and/or platelets and to time-varying plasma: red blood cell (RBC) and platelet: RBC ratios.
Design: Prospective cohort study documenting the timing of transfusions during active resuscitation and patient outcomes. Data were analyzed using time-dependent proportional hazards models.
Setting: Ten US level I trauma centers.
Patients: Adult trauma patients surviving for 30 minutes after admission who received a transfusion of at least 1 unit of RBCs within 6 hours of admission (n = 1245, the original study group) and at least 3 total units (of RBCs, plasma, or platelets) within 24 hours (n = 905, the analysis group).
Main Outcome Measure: In-hospital mortality.
Results: Plasma: RBC and platelet: RBC ratios were not constant during the first 24 hours (P < .001 for both). In a multivariable time-dependent Cox model, increased ratios of plasma: RBCs (adjusted hazard ratio = 0.31; 95% CI, 0.16-0.58) and platelets: RBCs (adjusted hazard ratio = 0.55; 95% CI, 0.31-0.98) were independently associated with decreased 6-hour mortality, when hemorrhagic death predominated. In the first 6 hours, patients with ratios less than 1: 2 were 3 to 4 times more likely to die than patients with ratios of 1: 1 or higher. After 24 hours, plasma and platelet ratios were unassociated with mortality, when competing risks from non-hemorrhagic causes prevailed.
Conclusions: Higher plasma and platelet ratios early in resuscitation were associated with decreased mortality in patients who received transfusions of at least 3 units of blood products during the first 24 hours after admission. Among survivors at 24 hours, the subsequent risk of death by day 30 was not associated with plasma or platelet ratios. JAMA Surg. 2013; 148(2): 127-136. Published online October 15, 2012. doi:10.1001/2013.jamasurg.387
C1 [Holcomb, John B.; del Junco, Deborah J.; Wade, Charles E.; Cohen, Mitchell J.; Matijevic, Nena] Univ Texas Hlth Sci Ctr Houston, Dept Surg, Div Acute Care Surg, Ctr Translat Injury Res, Houston, TX 77030 USA.
[Bai, Yu] Univ Texas Hlth Sci Ctr Houston, Dept Pathol & Lab Med, Houston, TX 77030 USA.
[del Junco, Deborah J.; Fox, Erin E.; Rahbar, Mohammad H.] Univ Texas Hlth Sci Ctr Houston, Sch Med, Biostat Epidemiol Res Design Core, Ctr Clin & Translat Sci, Houston, TX 77030 USA.
[Zhang, Jiajie] Univ Texas Hlth Sci Ctr Houston, Sch Biomed Informat, Houston, TX 77030 USA.
[Rahbar, Mohammad H.] Univ Texas Hlth Sci Ctr Houston, Div Epidemiol Human Genet & Environm Sci, Sch Publ Hlth, Houston, TX 77030 USA.
[Cohen, Mitchell J.] Univ Calif San Francisco, Sch Med, Dept Surg, Div Gen Surg, San Francisco, CA 94143 USA.
[Schreiber, Martin A.] Oregon Hlth & Sci Univ, Div Trauma Crit Care & Acute Care Surg, Portland, OR 97201 USA.
[Alarcon, Louis H.] Univ Pittsburgh, Sch Med, Dept Surg, Div Trauma & Gen Surg, Pittsburgh, PA USA.
[Brasel, Karen J.] Med Coll Wisconsin, Div Trauma & Crit Care, Milwaukee, WI 53226 USA.
[Bulger, Eileen M.] Univ Washington, Sch Med, Dept Surg, Div Trauma & Crit Care, Seattle, WA 98195 USA.
[Muskat, Peter] Univ Cincinnati, Coll Med, Dept Surg, Div Trauma Crit Care, Cincinnati, OH 45267 USA.
[Myers, John G.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, Sch Med, Div Trauma, San Antonio, TX 78229 USA.
[White, Christopher E.] Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, San Antonio, TX USA.
[Phelan, Herb A.] Univ Texas SW Med Ctr Dallas, Dept Surg, Sch Med, Div Burn Trauma Crit Care, Dallas, TX USA.
RP Holcomb, JB (reprint author), Univ Texas Hlth Sci Ctr Houston, Dept Surg, Div Acute Care Surg, Ctr Translat Injury Res, 6410 Fannin,Ste 1100, Houston, TX 77030 USA.
EM john.holcomb@uth.tmc.edu
FU Haemonetics Corp; KCI USA, Inc; Winkenwerder Co; US Army Medical
Research and Materiel Command [W81XWH-08-C-0712]; Clinical and
Translational Science Awards funds of grant from the National Institutes
of Health [UL1 RR024148]
FX Dr Holcomb has served on the board for Tenaxis, the Regional Advisory
Council for Trauma, and the National Trauma Institute; has provided
expert testimony for the Department of Justice; and has received grants
funded by Haemonetics Corp and KCI USA, Inc and consultant fees from The
Winkenwerder Co. Dr Wade has served on the science board for
Resuscitation Products, Inc and the advisory board for AstraZeneca.;
This work was supported by subcontract W81XWH-08-C-0712 from the US Army
Medical Research and Materiel Command. Infrastructure for the Data
Coordinating Center was supported by Clinical and Translational Science
Awards funds of grant UL1 RR024148 from the National Institutes of
Health.
NR 69
TC 187
Z9 193
U1 1
U2 18
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 2168-6254
J9 JAMA SURG
JI JAMA Surg.
PD FEB
PY 2013
VL 148
IS 2
BP 127
EP 136
DI 10.1001/2013.jamasurg.387
PG 10
WC Surgery
SC Surgery
GA 113PZ
UT WOS:000316681300004
PM 23560283
ER
PT J
AU Pathak, CS
AF Pathak, Chandra S.
TI Special Issue on Radar Rainfall Data Analyses and Applications
SO JOURNAL OF HYDROLOGIC ENGINEERING
LA English
DT Editorial Material
C1 USA, Corps Engineers, Washington, DC 20314 USA.
RP Pathak, CS (reprint author), USA, Corps Engineers, Washington, DC 20314 USA.
EM chandra.s.pathak@usace.army.mil
NR 0
TC 1
Z9 1
U1 0
U2 1
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 1084-0699
J9 J HYDROL ENG
JI J. Hydrol. Eng.
PD FEB
PY 2013
VL 18
IS 2
SI SI
BP 131
EP 132
DI 10.1061/(ASCE)HE.1943-5584.0000738
PG 2
WC Engineering, Civil; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA 111ZK
UT WOS:000316560700001
ER
PT J
AU Anagnostou, EN
Pathak, CS
Morales, CA
AF Anagnostou, Emmanouil N.
Pathak, Chandra S.
Morales, Carlos A.
TI Use of Storm Life Cycle Information and Lightning Data in Radar-Rainfall
Estimation
SO JOURNAL OF HYDROLOGIC ENGINEERING
LA English
DT Article
DE Radar rainfall; Rain gauge; Bias; Lightning; Storm tracking
ID CONVECTIVE SYSTEMS; UNITED-STATES; GAUGE DATA; PRECIPITATION; CLOUD;
BIAS; CALIBRATION; ERROR
AB Correcting real-time radar-rainfall estimates for mean field systematic errors (bias) is normally accomplished through gauge-based adjustment procedures. This study explores two auxiliary data sources derived from cloud-to-ground (CG) lightning measurements and storm tracking applied on radar images in terms of providing microphysical information useful for improving the efficiency of gauge-based bias adjustment techniques. The CG information is used to classify storms into thunderstorms (T-storms) versus showers (i.e., storms without lightning) and the tracking algorithm is used to classify storms according to their stage of maturity (i.e., growing, maturing, and decaying). Data for this study are based on high-resolution radar-rainfall estimates (2-km spatial grid resolution at 15-min intervals) available over the South Florida Water Management District for a period of 11 months, along with corresponding rain gauge measurements from 120 gauges and CG occurrences from the National Lightning Detection Network. The radar error analysis for T-storms versus showers and for the different storm maturity stages indicate that storm tracking and CG contain significant microphysical information that can improve radar-rainfall estimation. It is shown that radar rain estimates tend to underestimate convective rainfall, primarily associated with the growing stage of the storms or the occurrences of CG lightning; showers and storms at mature or decay stages are shown to be better represented by the standard reflectivity-rainfall (Z-R) relationship used for convective and tropical storms in Florida. Results from this study indicate that information regarding storm maturity stage derived from tracking radar images, and to a lesser extent, CG observations, can be used to reduce variability in the Z-R conversion and consequently improve accuracy in real-time radar-rainfall estimation. DOI: 10.1061/(ASCE)HE.1943-5584.0000557. (C) 2013 American Society of Civil Engineers.
C1 [Anagnostou, Emmanouil N.] Univ Connecticut, Dept Civil & Environm Engn, Storrs, CT 06269 USA.
[Pathak, Chandra S.] USA, Corps Engineers, Washington, DC 20314 USA.
[Pathak, Chandra S.] South Florida Water Management Dist, W Palm Beach, FL USA.
[Morales, Carlos A.] Univ Sao Paulo, Dept Atmospher Sci, Sao Paulo, Brazil.
RP Anagnostou, EN (reprint author), Univ Connecticut, Dept Civil & Environm Engn, Storrs, CT 06269 USA.
EM manos@engr.uconn.edu
FU South Florida Water Management District
FX This study was supported by the South Florida Water Management District.
Radar and rain gauge rainfall data were provided by the district. The
NLDN lightning data were acquired from NASA's Global Hydrology and
Climate Center.
NR 25
TC 1
Z9 1
U1 1
U2 5
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 1084-0699
J9 J HYDROL ENG
JI J. Hydrol. Eng.
PD FEB
PY 2013
VL 18
IS 2
SI SI
BP 168
EP 174
DI 10.1061/(ASCE)HE.1943-5584.0000557
PG 7
WC Engineering, Civil; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA 111ZK
UT WOS:000316560700005
ER
PT J
AU Malusis, MA
McKeehan, MD
AF Malusis, Michael A.
McKeehan, Matthew D.
TI Chemical Compatibility of Model Soil-Bentonite Backfill Containing
Multiswellable Bentonite
SO JOURNAL OF GEOTECHNICAL AND GEOENVIRONMENTAL ENGINEERING
LA English
DT Article
DE Backfill; Bentonite; Chemical Compatibility; Cutoff wall; Hydraulic
Conductivity; Vertical barrier
ID CALCIUM-CHLORIDE SOLUTIONS; GEOSYNTHETIC CLAY LINERS; HYDRAULIC
CONDUCTIVITY; BREAKTHROUGH CURVES; SALT-SOLUTIONS; COMPRESSIBILITY;
PERFORMANCE
AB The objective of this study was to evaluate the chemical compatibility of model soil-bentonite backfills containing multiswellable bentonite (MSB) relative to that of similar backfills containing untreated sodium (Na) bentonite or a commercially available, contaminant-resistant bentonite (SW101). Flexible-wall tests were conducted on consolidated backfill specimens (effective stress = 34.5 kPa) containing clean sand and 4.5-5.7% bentonite (by dry weight) using tap water and calcium chloride (CaCl2) solutions (10-1,000 mM) as the permeant liquids. Final values of hydraulic conductivity (k) and intrinsic permeability (K) to the CaCl2 solutions were determined after achieving both short-term termination criteria as defined by ASTM D5084 and long-term termination criteria for chemical equilibrium between the influent and effluent. Specimens containing MSB exhibited the smallest increases in k and K upon permeation with a given CaCl2 solution relative to specimens containing untreated Na bentonite or SW101. However, none of the specimens exhibited more than a fivefold increase in k or K, regardless of CaCl2 concentration or bentonite type. Final k values for specimens permeated with a given CaCl2 solution after permeation with tap water were similar to those for specimens of the same backfill permeated with only the CaCl2 solution, indicating that the order of permeation had no significant effect on k. Also, final k values for all specimens were within a factor of two of the k measured after achieving the ASTM D5084 termination criteria. Thus, use of only the ASTM D5084 criteria would have been sufficient to obtain reasonable estimates of long-term hydraulic conductivity for the specimens in this study. DOI: 10.1061/(ASCE)GT.1943-5606.0000729. (C) 2013 American Society of Civil Engineers.
C1 [Malusis, Michael A.; McKeehan, Matthew D.] Bucknell Univ, Dept Civil & Environm Engn, Lewisburg, PA 17837 USA.
[McKeehan, Matthew D.] USA, Corps Engineers, Ft Carson, CO 80913 USA.
RP Malusis, MA (reprint author), Bucknell Univ, Dept Civil & Environm Engn, Lewisburg, PA 17837 USA.
EM michael.malusis@bucknell.edu
NR 39
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Z9 13
U1 1
U2 9
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 1090-0241
J9 J GEOTECH GEOENVIRON
JI J. Geotech. Geoenviron. Eng.
PD FEB
PY 2013
VL 139
IS 2
BP 189
EP 198
DI 10.1061/(ASCE)GT.1943-5606.0000729
PG 10
WC Engineering, Geological; Geosciences, Multidisciplinary
SC Engineering; Geology
GA 111XX
UT WOS:000316556400001
ER
PT J
AU Bianchini, A
AF Bianchini, Alessandra
TI Evaluation of Temperature-Induced Curling in Concrete Slabs Using
Deflection Difference Analysis
SO JOURNAL OF TRANSPORTATION ENGINEERING-ASCE
LA English
DT Article
DE Heavy-weight deflectometer; Deflection; Slab curling; Impulse stiffness
modulus
ID PAVEMENTS
AB The curling and warping of rigid pavements are the results of temperature and moisture gradients varying with depth, creep, and other factors, including construction. The indicators commonly used to evaluate slab deformation include a combination of deflections derived from a heavy-weight deflectometer (HWD) that are measured at specific locations on pavement slabs. Indicators comprise the sum of deflections (SD) across the joints and the impulse stiffness modulus (ISM) deflection ratio. The objective of this study was to identify the best indicator that can be employed for assessing the slab curling level relationship to temperature. The study was included in a project developed by the U.S. Army Engineer Research and Development Center (ERDC) and sponsored by the Federal Aviation Administration (FAA). At selected military bases, HWD testing on concrete slabs was executed on two different occasions toward the end of summer and in winter. These tests were conducted to monitor slab deflections under different temperature conditions to quantify a correlation between measured deflections and temperature. The analysis showed that the SD rather than the ISM ratio could be adopted as an indicator to determine the relative degree of slab curling. The proposed approach to analyze deflection parameters showed promising results, and with a dedicated database and intensive testing, it is believed possible to refine the regression analysis and increase its level of determination. The proposed methodology for analyzing SD and temperature differences can be adopted in those cases intended to evaluate curling trend relationships to construction or curing techniques. DOI:10.1061/(ASCE)TE.1943-5436.0000490. (C) 2013 American Society of Civil Engineers.
C1 USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Bianchini, A (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM alessandra.bianchini@usace.army.mil
FU Airport Technology Research and Development Branch of the Federal
Aviation Administration
FX The work described in this paper was supported by the Airport Technology
Research and Development Branch of the Federal Aviation Administration
managed by Dr. Satish K. Agrawal. The contents of the paper reflect the
views of the author, who is responsible for the facts and accuracy of
the data presented. The contents do not necessarily reflect the official
views and policies of the Federal Aviation Administration or the U.S.
Army Engineer Research and Development Center. The paper does not
constitute a standard, specification, or regulation. Permission to
publish was granted by the Director of the Geotechnical and Structures
Laboratory.
NR 18
TC 0
Z9 1
U1 1
U2 9
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0733-947X
J9 J TRANSP ENG-ASCE
JI J. Transp. Eng.-ASCE
PD FEB
PY 2013
VL 139
IS 2
BP 130
EP 137
DI 10.1061/(ASCE)TE.1943-5436.0000490
PG 8
WC Engineering, Civil; Transportation Science & Technology
SC Engineering; Transportation
GA 110XE
UT WOS:000316480000003
ER
PT J
AU Masini, BD
Owens, BD
AF Masini, Brendan D.
Owens, Brett D.
TI Current Recommendations for Anterior Cruciate Ligament Bracing: When to
Use
SO PHYSICIAN AND SPORTSMEDICINE
LA English
DT Article
DE anterior cruciate ligament; prophylactic bracing; postoperative bracing;
functional bracing
ID FUNCTIONAL KNEE BRACE; RECONSTRUCTION; EXTENSION; FOOTBALL; INJURY
AB Braces are often used during various stages of recovery from an anterior cruciate ligament tear despite there being sparse definitive research supporting their use. This article reviews the literature on brace use for patients with anterior cruciate ligament tears in order to provide a guide for clinicians. There is evidence to support immediate postoperative bracing, with the goals of maintaining full extension and decreasing effusion. There may be a psychological benefit for its use in return to sport; however, this should be weighed against decreased performance. In the context of modern graft-fixation techniques and early mobilization protocols, empiric functional brace prescription is not required for successful long-term clinical outcomes and return to sport.
C1 [Masini, Brendan D.; Owens, Brett D.] Keller Army Community Hosp, West Point, NY 10996 USA.
RP Masini, BD (reprint author), Keller Army Community Hosp, 900 Washington Rd, West Point, NY 10996 USA.
EM brendan.masini@amedd.army.mil
NR 25
TC 0
Z9 0
U1 2
U2 22
PU JTE MULTIMEDIA
PI BERWYN
PA 1235 WESTLAKES DR, STE 220, BERWYN, PA 19312 USA
SN 0091-3847
J9 PHYSICIAN SPORTSMED
JI Physician Sportsmed.
PD FEB
PY 2013
VL 41
IS 1
BP 35
EP 39
DI 10.3810/psm.2013.02.1997
PG 5
WC Primary Health Care; Orthopedics; Sport Sciences
SC General & Internal Medicine; Orthopedics; Sport Sciences
GA 107ES
UT WOS:000316198200004
PM 23445858
ER
PT J
AU Britt, TW
Adler, AB
Bliese, PD
Moore, D
AF Britt, Thomas W.
Adler, Amy B.
Bliese, Paul D.
Moore, DeWayne
TI Morale as a Moderator of the Combat Exposure-PTSD Symptom Relationship
SO JOURNAL OF TRAUMATIC STRESS
LA English
DT Article
ID PERCEIVED ORGANIZATIONAL SUPPORT; POSTTRAUMATIC-STRESS-DISORDER;
MENTAL-HEALTH PROBLEMS; IRAQ; INVOLVEMENT; CONSEQUENCES; PERSONALITY;
AFGHANISTAN; DEPRESSION; PSYCHOLOGY
AB We examined morale as a moderator of the relationship between combat exposure and posttraumatic stress disorder (PTSD) symptoms in a longitudinal study of U. S. soldiers who had participated in a deployment to Iraq. Soldiers (N = 636) completed assessments at 4 (Time 1) and 10 (Time 2) months following their combat deployment. Combat exposure (both breadth and perceived stressfulness), morale, and PTSD symptoms were assessed at Time 1, and PTSD symptoms were assessed again at Time 2. Results of multivariate multiple regressions revealed that morale at Time 1 interacted with both the breadth and stressfulness of combat exposure to predict PTSD symptoms at both Time 1 and Time 2, even when partialling out the effect of unit support. The slope of the given combat exposure and PTSD symptoms relationship was weaker when reports of morale were higher (with the effect size of the interaction ranging from .01 to .04). The results suggest that morale may buffer soldiers from the negative consequences of combat stressors.
C1 [Britt, Thomas W.; Bliese, Paul D.] Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD USA.
[Britt, Thomas W.; Adler, Amy B.] Walter Reed Army Inst Res, US Army Med Res Unit Europe, Heidelberg, Germany.
[Britt, Thomas W.; Moore, DeWayne] Clemson Univ, Clemson, SC 29634 USA.
RP Britt, TW (reprint author), Clemson Univ, Dept Psychol, Clemson, SC 29634 USA.
EM twbritt@clemson.edu
NR 44
TC 11
Z9 13
U1 1
U2 16
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0894-9867
J9 J TRAUMA STRESS
JI J. Trauma Stress
PD FEB
PY 2013
VL 26
IS 1
BP 94
EP 101
DI 10.1002/jts.21775
PG 8
WC Psychology, Clinical; Psychiatry
SC Psychology; Psychiatry
GA 092CH
UT WOS:000315095900012
PM 23371305
ER
PT J
AU Kerubo, LO
Midiwo, JO
Derese, S
Langat, MK
Akala, HM
Waters, NC
Peter, M
Heydenreich, M
AF Kerubo, Leonidah Omosa
Midiwo, Jacob Ogweno
Derese, Solomon
Langat, Moses K.
Akala, Hosea M.
Waters, Norman C.
Peter, Martin
Heydenreich, Matthias
TI Antiplasmodial Activity of Compounds from the Surface Exudates of
Senecio roseiflorus
SO NATURAL PRODUCT COMMUNICATIONS
LA English
DT Article
DE Senecio roseiflorus; Asteraceae; Surface exudates; Antiplasmodial
activity
ID FLAVONOIDS; VISCOSA; GROWTH
AB From the surface exudates of Senecio roseiflorus fourteen known methylated flavonoids and one phenol were isolated and characterized. The structures of these compounds were determined on the basis of their spectroscopic analysis. The surface exudate and the flavonoids isolated showed moderate to good antiplasmodial activity with 5,4'-dihydroxy-7-dimethoxyflavanone having the highest activity against chloroquine-sensitive (D6) and resistant (W2) strains of Plasmodium falciparum, with IC50 values of 3.2 +/- 0.8 and 4.4 +/- 0.01 mu g/mL respectively.
C1 [Kerubo, Leonidah Omosa; Midiwo, Jacob Ogweno; Derese, Solomon] Univ Nairobi, Dept Chem, Nairobi, Kenya.
[Langat, Moses K.] Univ Surrey, FEPS, Dept Chem, Guildford GU2 7XH, Surrey, England.
[Akala, Hosea M.; Waters, Norman C.] USA, Med Res Unit Kenya, Walter Reed Project, APO, AE 09831 USA.
[Peter, Martin; Heydenreich, Matthias] Univ Potsdam, Inst Chem, D-14415 Potsdam, Germany.
RP Langat, MK (reprint author), Univ Surrey, FEPS, Dept Chem, Guildford GU2 7XH, Surrey, England.
EM m.langat@surrey.ac.uk
RI Derese, Solomon/H-5957-2016;
OI Derese, Solomon/0000-0002-2640-3583; Heydenreich,
Matthias/0000-0003-1639-4959
FU German Academic Exchange Service (DAAD); Deutsche
Forschungsgemeinschaft, Germany [Pe 264/ 14-5]; Bundesministerium fur
Zusammenarbeit [Pe-254/14-6]
FX The authors are grateful to Mr Simon Mathenge for collection and
identification of the plant material. LKO would like to thank sincerely
the German Academic Exchange Service (DAAD) for a PhD scholarship. A
grant for this research was also provided by the Deutsche
Forschungsgemeinschaft, Germany, Grant No. Pe 264/ 14-5 and by the
Bundesministerium fur Zusammenarbeit, Grant No. Pe-254/14-6.
NR 17
TC 1
Z9 2
U1 0
U2 4
PU NATURAL PRODUCTS INC
PI WESTERVILLE
PA 7963 ANDERSON PARK LN, WESTERVILLE, OH 43081 USA
SN 1934-578X
J9 NAT PROD COMMUN
JI Nat. Prod. Commun.
PD FEB
PY 2013
VL 8
IS 2
BP 175
EP 176
PG 2
WC Chemistry, Medicinal; Food Science & Technology
SC Pharmacology & Pharmacy; Food Science & Technology
GA 095XT
UT WOS:000315369000010
PM 23513721
ER
PT J
AU Walker, JA
Rossini, G
Thompson, ME
Wenke, JC
Baer, DG
AF Walker, John A.
Rossini, Gianni
Thompson, Michelle E.
Wenke, Joseph C.
Baer, David G.
TI Effect of Proteasome Inhibitor 1 on Wound Healing: A Potential Scar
Prevention Therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID GROWTH-FACTOR-BETA; MATRIX METALLOPROTEINASES; HYPERTROPHIC SCARS;
FIBROSIS; SKIN; FETAL; FIBROBLASTS; EXPRESSION; COLLAGEN; REPAIR
AB In vitro and in vivo assessments suggest that proteasome inhibitors may be useful for modulating wound healing. Methods. Proteasome Inhibitor I was used to assess the potential utility of proteasome inhibitors in improving wound healing in a standard rat model. Bilateral, 6 cm incisions were made 1 cm lateral to the spine of adult male Sprague Dawley rats. Animals were randomly assigned to 1 of 3 groups: no treatment (n = 15), low concentration (1% w/v, n = 15), or high concentration (5% w/v, n = 15). Treatments were applied to the left side incision at 0 hours, 24 hours, and 48 hours. Right-side incisions received a vehicle, dimethyl sulfoxide, alone and independent of the assigned group, serving as both external and internal controls. Rats were sacrificed at days 7, 14, and 28 (n = 5 per group) and wounds subjected to mechanical testing and histology. Results. No significant intergroup difference existed at 7 and 14 days. On day 28, a dose-dependent increase in tensile strength with increasing Proteasome Inhibitor I was, observed. Conclusion. Results suggest dimethyl sulfoxide was not the ideal vehicle and additional improvement may be realized by optimizing the delivery method.
C1 [Walker, John A.] Univ Texas Hlth Sci Ctr San Antonio, Sch Med, Dept Radiol, San Antonio, TX 78229 USA.
[Rossini, Gianni] SW Res Inst, Dept Biochem & Biomat, San Antonio, TX USA.
[Thompson, Michelle E.] Tri Serv Res Lab, Dept Pathol, San Antonio, TX USA.
[Wenke, Joseph C.; Baer, David G.] USA, Inst Surg Res, Regenerat Med Task Area, San Antonio, TX USA.
RP Walker, JA (reprint author), 7703 Floyd Curl Dr,MS 7800, San Antonio, TX 78229 USA.
EM walkerja@livemail.uthscsa.edu
FU United States Department of Defense funds (USAMRMC) [W81XWH-07-1-0717]
FX This study has been conducted in compliance with the Animal Welfare Act,
the implementing Animal Welfare Regulations, and the principles of the
Guide for the Care and Use of Laboratory Animals. This study was
supported in part by the United States Department of Defense funds
(USAMRMC # W81XWH-07-1-0717).
NR 26
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U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2013
VL 25
IS 2
BP 28
EP 33
PG 6
WC Dermatology; Surgery
SC Dermatology; Surgery
GA 096UM
UT WOS:000315430100003
PM 25867804
ER
PT J
AU Allison, PG
Chandler, MQ
Rodriguez, RI
Williams, BA
Moser, RD
Weiss, CA
Poda, AR
Lafferty, BJ
Kennedy, AJ
Seiter, JM
Hodo, WD
Cook, RF
AF Allison, P. G.
Chandler, M. Q.
Rodriguez, R. I.
Williams, B. A.
Moser, R. D.
Weiss, C. A., Jr.
Poda, A. R.
Lafferty, B. J.
Kennedy, A. J.
Seiter, J. M.
Hodo, W. D.
Cook, R. F.
TI Mechanical properties and structure of the biological multilayered
material system, Atractosteus spatula scales
SO ACTA BIOMATERIALIA
LA English
DT Article
DE Atractosteus spatula; Scale; Indentation; Structure; Mechanical
properties
ID DESIGN; NACRE; LEPISOSTEUS; FRACTURE; MOTHER; PEARL; ARMOR
AB During recent decades, research on biological systems such as abalone shell and fish armor has revealed that these biological systems employ carefully arranged hierarchical multilayered structures to achieve properties of high strength, high ductility and light weight. Knowledge of such structures may enable pathways to design bio-inspired materials for various applications. This study was conducted to investigate the spatial distribution of structure, chemical composition and mechanical properties in mineralized fish scales of the species Atractosteus spatula. Microindentation tests were conducted, and cracking patterns and damage sites in the scales were examined to investigate the underlying protective mechanisms of fish scales under impact and penetration loads. A difference in nanomechanical properties was observed, with a thinner, stiffer and harder outer layer (indentation modulus similar to 69 GPa and hardness similar to 3.3 GPa) on a more compliant and thicker inner layer (indentation modulus similar to 14.3 GPa and hardness similar to 0.5 GPa). High-resolution scanning electron microscopy imaging of a fracture surface revealed that the outer layer contained oriented nanorods embedded in a matrix, and that the nanostructure of the inner layer contained fiber-like structures organized in a complex layered pattern. Damage patterns formed during microindentation show complex deformation mechanisms. Images of cracks identify growth through the outer layer, then deflection along the interface before growing and arresting in the inner layer. High-magnification images of the crack tip in the inner layer show void-linking and fiber-bridging exhibiting inelastic behavior. The observed difference in mechanical properties and unique nanostructures of different layers may have contributed to the resistance of fish scales to failure by impact and penetration loading. Published by Elsevier Ltd. on behalf of Acta Materialia Inc.
C1 [Allison, P. G.; Chandler, M. Q.; Williams, B. A.; Moser, R. D.; Weiss, C. A., Jr.; Hodo, W. D.] USA, Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA.
[Rodriguez, R. I.] Univ Puerto Rico, Dept Mech Engn, Mayaguez, PR 00681 USA.
[Poda, A. R.; Lafferty, B. J.; Kennedy, A. J.; Seiter, J. M.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
[Cook, R. F.] NIST, Div Ceram, Gaithersburg, MD 20899 USA.
RP Allison, PG (reprint author), USA, Engineer Res & Dev Ctr, Geotech & Struct Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM Paul.G.Allison@usace.army.mil
RI Poda, Aimee/K-1905-2012;
OI Allison, Paul/0000-0002-9041-237X
FU US Army ERDC Military Engineering 6.1 Basic Research Program; ERDC
Center for Directed Research Program
FX The authors acknowledge the financial support for this work provided by
the US Army ERDC Military Engineering 6.1 Basic Research Program and the
ERDC Center for Directed Research Program. Discussions about this
research with Drs. Mark Horstemeyer (MSU), Hongjoo Rhee (MSU), Christine
Ortiz (MIT), Mark Myers (UCSD) and many others are gratefully
acknowledged. The authors thank the staff and facilities of the ERDC
Geotechnical and Structural Laboratory's Concrete and Materials Branch
for supporting the experimental work. Permission to publish was granted
by the Director, Geotechnical and Structures Laboratory, US Army
Engineer Research and Development Center.
NR 25
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Z9 13
U1 3
U2 62
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1742-7061
EI 1878-7568
J9 ACTA BIOMATER
JI Acta Biomater.
PD FEB
PY 2013
VL 9
IS 2
BP 5289
EP 5296
DI 10.1016/j.actbio.2012.11.005
PG 8
WC Engineering, Biomedical; Materials Science, Biomaterials
SC Engineering; Materials Science
GA 093DB
UT WOS:000315170800037
PM 23149253
ER
PT J
AU Westbrook, CJ
Veatch, W
Morrison, A
AF Westbrook, Cherie J.
Veatch, William
Morrison, Alasdair
TI Ecohydrology Bearings - Invited Commentary Is ecohydrology missing much
of the zoo?
SO ECOHYDROLOGY
LA English
DT Article
ID WATER-CONTROLLED ECOSYSTEMS; LANDFILL COVERS; NATIONAL-PARK; PRAIRIE
DOG; PLANT; HERBIVORY; EROSION; ORGANISMS; ENGINEERS; HYDROLOGY
AB Ecohydrology is now recognized as an interdisciplinary field, and as it grows, there needs to be greater awareness and dialogue on its focus and future direction. To take a bearings' on where we are, 339 ecohydrological articles published between January 2000 and December 2011 in two databases were surveyed. We found that 72% of the studies address questions at the interface of plant ecology and hydrology. The scarcity of studies of animals as drivers of hydrological patterns and processes led us to question the reasons behind plant-based ecologists embracing the term ecohydrology to a greater extent than animal-based ecologists. Following that discussion are current examples of synergies between animal ecologists and hydrologists that have led to a greater understanding of ecosystem processes and a way for ecohydrologists to factor in faunal interactions in their future research. We end by suggesting that ecohydrology form its own scientific society so it can more purposely advance knowledge and understanding of coupled ecological and hydrological system functions. Copyright (c) 2013 John Wiley & Sons, Ltd.
C1 [Westbrook, Cherie J.; Morrison, Alasdair] Univ Saskatchewan, Ctr Hydrol, Saskatoon, SK S7N 5C8, Canada.
[Westbrook, Cherie J.; Morrison, Alasdair] Univ Saskatchewan, Dept Geog & Planning, Saskatoon, SK S7N 5C8, Canada.
[Veatch, William] USA, Corps Engineers, CEMVN ED H, New Orleans, LA USA.
RP Westbrook, CJ (reprint author), Univ Saskatchewan, Ctr Hydrol, Saskatoon, SK S7N 5C8, Canada.
EM cherie.westbrook@usask.ca
FU Natural Science and Engineering Research Council of Canada (NSERC);
Global Institute for Water Security
FX The idea for this manuscript was inspired by separate discussions in
graduate ecohydrology at the universities of Saskatchewan and Arizona.
We thank David Eldridge and Paul Whitfield for insightful comments that
challenged us and considerably strengthened the paper. The Natural
Science and Engineering Research Council of Canada (NSERC) and the
Global Institute for Water Security supported this research.
NR 61
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U1 0
U2 39
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1936-0584
J9 ECOHYDROLOGY
JI Ecohydrology
PD FEB
PY 2013
VL 6
IS 1
BP 1
EP 7
DI 10.1002/eco.1365
PG 7
WC Ecology; Environmental Sciences; Water Resources
SC Environmental Sciences & Ecology; Water Resources
GA 092HL
UT WOS:000315110900002
ER
PT J
AU Rogers, CJ
AF Rogers, Clifford J.
TI Bloodied Banners: Martial Display on the Medieval Battlefield
SO ENGLISH HISTORICAL REVIEW
LA English
DT Book Review
C1 [Rogers, Clifford J.] US Mil Acad W Point, West Point, NY USA.
RP Rogers, CJ (reprint author), US Mil Acad W Point, West Point, NY USA.
NR 1
TC 0
Z9 0
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0013-8266
J9 ENGL HIST REV
JI Engl. Hist. Rev.
PD FEB
PY 2013
VL 128
IS 530
BP 131
EP 133
DI 10.1093/ehr/ces350
PG 4
WC History
SC History
GA 089DV
UT WOS:000314890500018
ER
PT J
AU Foster, N
Guha, A
Reitblatt, M
Story, A
Freedman, MJ
Katta, NP
Monsanto, C
Reich, J
Rexford, J
Schlesinger, C
Walker, D
Harrison, MR
AF Foster, Nate
Guha, Arjun
Reitblatt, Mark
Story, Alec
Freedman, Michael J.
Katta, Naga Praveen
Monsanto, Christopher
Reich, Joshua
Rexford, Jennifer
Schlesinger, Cole
Walker, David
Harrison, Major Robert
TI Languages for Software-Defined Networks
SO IEEE COMMUNICATIONS MAGAZINE
LA English
DT Article
AB Modern computer networks perform a bewildering array of tasks, from routing and traffic monitoring, to access control and server load balancing. However, managing these networks is unnecessarily complicated and error-prone, due to a heterogeneous mix of devices (e.g., routers, switches, firewalls, and middleboxes) with closed and proprietary configuration interfaces. Software-defined networks are poised to change this by offering a clean and open interface between networking devices and the software that controls them. In particular, many commercial switches support the OpenFlow protocol, and a number of campus, data center, and backbone networks have deployed the new technology. However, while SDNs make it possible to program the network, they does not make it easy. Today's OpenFlow controllers offer low-level APIs that mimic the underlying switch hardware. To reach SDNs' full potential, we need to identify the right higher-level abstractions for creating (and composing) applications. In the Frenetic project, we are designing simple and intuitive abstractions for programming the three main stages of network management: monitoring network traffic, specifying and composing packet forwarding policies, and updating policies in a consistent way. Overall, these abstractions make it dramatically easier for programmers to write and reason about SDN applications.
C1 [Foster, Nate; Guha, Arjun; Reitblatt, Mark; Story, Alec] Cornell Univ, Ithaca, NY 14853 USA.
[Freedman, Michael J.; Katta, Naga Praveen; Monsanto, Christopher; Reich, Joshua; Rexford, Jennifer; Schlesinger, Cole; Walker, David] Princeton Univ, Princeton, NJ 08544 USA.
[Harrison, Major Robert] US Mil Acad, West Point, NY USA.
RP Foster, N (reprint author), Cornell Univ, Ithaca, NY 14853 USA.
EM princedpw@gmail.com
FU ONR [N00014-09-1-0770, N00014-09-1-0652]; NSF [CNS-1111698,
CNS-1111520]; TRUST
FX Our work is supported in part by ONR grants N00014-09-1-0770 and
N00014-09-1-0652, NSF grants CNS-1111698 and CNS-1111520, TRUST, and
gifts from Dell, Intel, and Google. Any opinions, findings, and
recommendations are those of the authors and do not necessarily reflect
the views of the ONR or NSF.
NR 17
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U1 6
U2 85
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0163-6804
EI 1558-1896
J9 IEEE COMMUN MAG
JI IEEE Commun. Mag.
PD FEB
PY 2013
VL 51
IS 2
BP 128
EP 134
PG 7
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA 092LF
UT WOS:000315122400018
ER
PT J
AU Walsh, GF
Dal Negro, L
AF Walsh, Gary F.
Dal Negro, Luca
TI Engineering Plasmon-Enhanced Au Light Emission with Planar Arrays of
Nanoparticles
SO NANO LETTERS
LA English
DT Article
DE Plasmonics; photoluminescence; optical sensor; efficiency; radiative
engineering; plasmon decay
ID SILVER NANOPARTICLES; GOLD NANORODS; NOBLE-METALS; SPECTROSCOPY; DIMERS;
PHOTOLUMINESCENCE; RESONANCE; CELLS
AB By systematically investigating the light emission and scattering properties of arrays of Au nanoparticles with varying size and separation, we demonstrate tunability and control of metal photoluminescence and unveil the critical role of near-field plasmonic coupling for the engineering of active metal nanostructures. We show that the decay of photoexcited electron-hole pairs into localized surface plasmons (LSPs) dramatically modifies the Au emission wavelength, line shape, and quantum efficiency depending both on particles size and separation. In particular, in arrays with near-field coupled nanoparticles we demonstrate broad light scattering and emission spectra that scale differently with respect to nanoparticle size due to the enhanced LSP nonradiative decay caused by near-field interparticle coupling. Our experimental results are fully supported by semianalytical extinction simulations based on rigorous coupled wave analysis, which demonstrate the importance of tuning plasmonic near-field coupling for the engineering of active devices based on light emitting arrays of metallic nanoparticles.
C1 [Walsh, Gary F.; Dal Negro, Luca] Boston Univ, Dept Elect & Comp Engn, Boston, MA 02215 USA.
[Walsh, Gary F.; Dal Negro, Luca] Boston Univ, Photon Ctr, Boston, MA 02215 USA.
[Walsh, Gary F.] USA, NSRDEC, Nanomat Sci Team, Natick, MA 01760 USA.
[Dal Negro, Luca] Boston Univ, Div Mat Sci & Engn, Brookline, MA 02446 USA.
RP Dal Negro, L (reprint author), Boston Univ, Dept Elect & Comp Engn, 8 St Marys St, Boston, MA 02215 USA.
EM dalnegro@bu.edu
FU U.S. Army Natick Soldier Research, Development, and Engineering Center;
SMART Scholarship Program. NSRDEC PAO [U12-550]
FX This work was supported by the U.S. Army Natick Soldier Research,
Development, and Engineering Center, and the SMART Scholarship Program.
NSRDEC PAO# U12-550. All authors have given approval to the final
version of the manuscript.
NR 37
TC 26
Z9 27
U1 0
U2 113
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1530-6984
EI 1530-6992
J9 NANO LETT
JI Nano Lett.
PD FEB
PY 2013
VL 13
IS 2
BP 786
EP 792
DI 10.1021/nl304523v
PG 7
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA 091WC
UT WOS:000315079500077
PM 23339774
ER
PT J
AU Wachs, JJ
Wilson, GT
AF Wachs, John J.
Wilson, Gerald T.
TI United States army tactical high-energy laser program
SO OPTICAL ENGINEERING
LA English
DT Article
DE high energy laser; deuterium fluoride laser; beam control; counter
rocket
AB The tactical high energy laser (THEL) program, conducted from 1996 to 2005, successfully demonstrated the capability of a high-energy laser to counter rockets, artillery, and mortars. The program was a US/Israeli cooperative research and development effort that was designated by the Secretary of Defense as an advanced concept technology demonstration with Presidential interest. The THEL system was designed and built under an SMDC/ARSTART prime contract awarded to TRW (now, Northrop Grumman Corporation), jointly managed by the Israel Ministry of Defence Directorate of Defence Research & Development. We summarize the effort and highlight some of the "firsts" of the THEL program. (c) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.OE.52.2.021009]
C1 [Wachs, John J.] USA, Space & Missile Def Command, Army Forces Strateg Command USASMDC ARSTRAT, Ctr Tech,SMDC TC ED, Redstone Arsenal, AL 35898 USA.
[Wilson, Gerald T.] SFAE MSLS CMDS SE, PEO M&S, Redstone Arsenal, AL 35898 USA.
RP Wachs, JJ (reprint author), USA, Space & Missile Def Command, Army Forces Strateg Command USASMDC ARSTRAT, Ctr Tech,SMDC TC ED, Bldg 5220, Redstone Arsenal, AL 35898 USA.
EM john.j.wachs.civ@mail.mil
NR 2
TC 0
Z9 0
U1 1
U2 12
PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA
SN 0091-3286
EI 1560-2303
J9 OPT ENG
JI Opt. Eng.
PD FEB
PY 2013
VL 52
IS 2
AR 021009
DI 10.1117/1.OE.52.2.021009
PG 4
WC Optics
SC Optics
GA 092WX
UT WOS:000315154800013
ER
PT J
AU Wolf, JM
Cameron, KL
Clifton, KB
Owens, BD
AF Wolf, Jennifer Moriatis
Cameron, Kenneth L.
Clifton, Kari B.
Owens, Brett D.
TI Serum Relaxin Levels in Young Athletic Men Are Comparable With Those in
Women
SO ORTHOPEDICS
LA English
DT Article
ID ANTERIOR CRUCIATE LIGAMENT; MENSTRUAL-CYCLE; DISEASE; PREGNANCY;
RECEPTORS; PROSTATE; FIBROSIS; BINDING
AB Relaxin was originally described as a reproductive hormone that mediated joint laxity in pregnant women and has been minimally studied in men. The purpose of this descriptive laboratory and clinical study was to evaluate serum relaxin in a young, primarily male population and compare levels between the sexes. In addition, the authors evaluated the relationship between relaxin and generalized laxity.
C1 [Wolf, Jennifer Moriatis; Clifton, Kari B.] Univ Connecticut, Ctr Hlth, Dept Orthopaed Surg, Farmington, CT 06030 USA.
[Cameron, Kenneth L.; Owens, Brett D.] United States Mil Acad, Keller Army Hosp, West Point, NY USA.
RP Wolf, JM (reprint author), Univ Connecticut, Ctr Hlth, Dept Orthopaed Surg, 263 Farmington Ave, Farmington, CT 06030 USA.
EM jmwolf@uchc.edu
OI Cameron, Kenneth/0000-0002-6276-4482
FU Prospective Research Grant from the Orthopaedic Research and Education
Foundation; Connecticut Institute of Clinical and Translational Science
(Clinical Research Center Grant) [M01RR006192]
FX This study was supported by a Prospective Research Grant from the
Orthopaedic Research and Education Foundation (BDO) and pilot funding
from the Connecticut Institute of Clinical and Translational Science
(Clinical Research Center Grant #M01RR006192) (JMW).
NR 21
TC 6
Z9 7
U1 0
U2 4
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0147-7447
J9 ORTHOPEDICS
JI Orthopedics
PD FEB
PY 2013
VL 36
IS 2
BP 128
EP 131
DI 10.3928/01477447-20130122-06
PG 4
WC Orthopedics
SC Orthopedics
GA 093PW
UT WOS:000315204800030
PM 23379736
ER
PT J
AU Janosi, L
Compton, JR
Legler, PM
Steele, KE
Davis, JM
Matyas, GR
Millard, CB
AF Janosi, Laszlo
Compton, Jaimee R.
Legler, Patricia M.
Steele, Keith E.
Davis, Jon M.
Matyas, Gary R.
Millard, Charles B.
TI Disruption of the Putative Vascular Leak Peptide Sequence in the
Stabilized Ricin Vaccine Candidate RTA1-33/44-198
SO TOXINS
LA English
DT Article
DE ricin; recombinant vaccines; vascular leak peptide; amino acid
substitutions; BALB/c mice; D75N/R48C/T77C; RTA1-33/44-198
ID A-CHAIN; MOLECULAR-GRAPHICS; PROTEIN VACCINE; MICE; INHALATION;
PROTECTION; ANTIBODIES; EFFICACY; AEROSOL; BINDING
AB Vitetta and colleagues identified and characterized a putative vascular leak peptide (VLP) consensus sequence in recombinant ricin toxin A-chain (RTA) that contributed to dose-limiting human toxicity when RTA was administered intravenously in large quantities during chemotherapy. We disrupted this potentially toxic site within the more stable RTA1-33/44-198 vaccine immunogen and determined the impact of these mutations on protein stability, structure and protective immunogenicity using an experimental intranasal ricin challenge model in BALB/c mice to determine if the mutations were compatible. Single amino acid substitutions at the positions corresponding with RTA D75 (to A, or N) and V76 (to I, or M) had minor effects on the apparent protein melting temperature of RTA1-33/44-198 but all four variants retained greater apparent stability than the parent RTA. Moreover, each VLP(-) variant tested provided protection comparable with that of RTA1-33/44-198 against supralethal intranasal ricin challenge as judged by animal survival and several biomarkers. To understand better how VLP substitutions and mutations near the VLP site impact epitope structure, we introduced a previously described thermal stabilizing disulfide bond (R48C/T77C) along with the D75N or V76I substitutions in RTA1-33/44-198. The D75N mutation was compatible with the adjacent stabilizing R48C/T77C disulfide bond and the T-m was unaffected, whereas the V76I mutation was less compatible with the adjacent disulfide bond involving C77. A crystal structure of the RTA1-33/44-198 R48C/T77C/D75N variant showed that the structural integrity of the immunogen was largely conserved and that a stable immunogen could be produced from E. coli. We conclude that it is feasible to disrupt the VLP site in RTA1-33/44-198 with little or no impact on apparent protein stability or protective efficacy in mice and such variants can be stabilized further by introduction of a disulfide bond.
C1 [Janosi, Laszlo; Steele, Keith E.; Matyas, Gary R.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
[Compton, Jaimee R.] NOVA Res Inc, Alexandria, VA 22308 USA.
[Legler, Patricia M.] USN, Res Labs, Washington, DC 20375 USA.
[Davis, Jon M.] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
[Millard, Charles B.] USA, Med Res & Mat Command, Ft Detrick, MD 21702 USA.
RP Legler, PM (reprint author), USN, Res Labs, 4555 Overlook Ave, Washington, DC 20375 USA.
EM lacipaci@yahoo.com; jaimee.compton.ctr@nrl.navy.mil;
patricia.legler@nrl.navy.mil; steeleK@medImmune.com; jon.davis@osd.mil;
gmatyas@hivresearch.org; charles.b.millard@us.army.mil
OI Matyas, Gary/0000-0002-2074-2373
FU U.S. Army; Defense Threat Reduction Agency (DTRA) Joint Science &
Technology Office award [S.S.0003_06_WR_B]; National Institutes of
Health (NIH) [5U01AI082120-04]
FX We would like to thank Paul Facemire for providing photographs of
healthy lung tissue. This work was supported by the U.S. Army and a
Defense Threat Reduction Agency (DTRA) Joint Science & Technology Office
award S.S.0003_06_WR_B (to CBM) and National Institutes of Health (NIH)
sub-award 5U01AI082120-04 (to PML). The opinions or assertions contained
herein belong to the authors and are not necessarily the official views
of the U.S. Army, U.S. Navy, the U.S. Department of Defense, or the NIH.
NR 31
TC 1
Z9 2
U1 1
U2 6
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2072-6651
J9 TOXINS
JI Toxins
PD FEB
PY 2013
VL 5
IS 2
BP 224
EP 248
DI 10.3390/toxins5020224
PG 25
WC Toxicology
SC Toxicology
GA 096MJ
UT WOS:000315408000002
PM 23364220
ER
PT J
AU Swierczewski, BE
Odundo, EA
Koech, MC
Ndonye, JN
Kirera, RK
Odhiambo, CP
Cheruiyot, EK
Wu, MT
Lee, JE
Zhang, CL
Oaks, EV
AF Swierczewski, Brett E.
Odundo, Elizabeth A.
Koech, Margaret C.
Ndonye, Janet N.
Kirera, Ronald K.
Odhiambo, Cliff P.
Cheruiyot, Erick K.
Wu, Max T.
Lee, James E.
Zhang, Chunlin
Oaks, Edwin V.
TI Surveillance for enteric pathogens in a case-control study of acute
diarrhea in Western Kenya
SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
DE Gastroenteritis; Protozoa; Rotavirus; Shigella; Escherichia coli;
Antimicrobial resistance
ID SPECTRUM BETA-LACTAMASE; ESCHERICHIA-COLI; CHILDHOOD DIARRHEA;
GIARDIA-LAMBLIA; ANTIMICROBIAL RESISTANCE; DEVELOPING-COUNTRIES;
PERSISTENT DIARRHEA; BACTERIAL DIARRHEA; FECAL SPECIMENS; HIGH
PREVALENCE
AB Background: Acute diarrhea remains a major public health problem in East African nations such as Kenya. Surveillance for a broad range of enteric pathogens is necessary to accurately predict the frequency of pathogens and potential changes in antibiotic resistance patterns.
Method: Stool samples were collected from September 2009 to September 2011; 193 and 239 samples, from age-matched cases and asymptomatic controls, were collected, respectively, from Kericho and Kisumu District Hospitals in western Kenya. Bacterial pathogens were identified by conventional microbiological methods; antibiotic susceptibility of bacterial isolates was ascertained using the Micro Scan Walk Away 40 Plus. An enzyme immunoassay kit was used to detect rotavirus, and ova and parasite examination was conducted by microscopy and an enzyme immunoassay.
Results: Rotavirus (10.2% and 10.5%) and Shigella (11% and 8%) were isolated significantly more often in the cases than the controls from Kericho and Kisumu District Hospitals respectively. The diarrheagenic Escherichia coli, Campylobacter jejuni and Salmonella were found most often in the cases while Giardia lamblia and Entamoeba histolytica/E. dispar were found more often in the controls. Most pathogens were isolated from children under 5 years old. More than 50% of the Shigella, Salmonella and diarrheagenic E. coli isolates were multidrug resistant to ampicillin, tetracycline and trimethoprim/sulfamethoxazole with several enteroaggregative and enterotoxigenic E. coli isolates producing extended-spectrum beta-lactamases.
Conclusion: Accurate epidemiologic information on acute diarrheal illness in Kenya will be critical for augmenting existing diarrhea management policies in terms of treatment and to strengthen future community awareness and health promotion programs.
C1 [Swierczewski, Brett E.; Odundo, Elizabeth A.; Koech, Margaret C.; Ndonye, Janet N.; Kirera, Ronald K.; Odhiambo, Cliff P.; Cheruiyot, Erick K.] US Army Med Res Unit Kenya, Kericho Field Stn, Chilung 20220, Taiwan.
[Wu, Max T.; Lee, James E.; Zhang, Chunlin; Oaks, Edwin V.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD USA.
RP Swierczewski, BE (reprint author), US Army Med Res Unit Kenya, Kericho Field Stn, POB 1357,Hosp Rd, Chilung 20220, Taiwan.
EM brett.swierczewski@us.army.mil
RI Valle, Ruben/A-7512-2013
FU Armed Forces Health Surveillance Center-Global Emerging Infections
Surveillance and Response Systems, Silver Spring, MD, USA
FX This study was funded by the Armed Forces Health Surveillance
Center-Global Emerging Infections Surveillance and Response Systems,
Silver Spring, MD, USA.
NR 54
TC 9
Z9 10
U1 0
U2 17
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0035-9203
J9 T ROY SOC TROP MED H
JI Trans. Roy. Soc. Trop. Med. Hyg.
PD FEB
PY 2013
VL 107
IS 2
BP 83
EP 90
DI 10.1093/trstmh/trs022
PG 8
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 095EX
UT WOS:000315318600003
PM 23222955
ER
PT J
AU Ferguson, BK
Ferguson, BK
Mickalonis, O
AF Ferguson, Bruce K.
Ferguson, Benjamin K.
Mickalonis, Olivia
TI Aggregate selection and cost for impervious surface reduction
SO URBAN WATER JOURNAL
LA English
DT Article
DE permeable surfaces; aggregate; pervious surface; cost
ID HYDRAULIC CONDUCTIVITY; KOZENY-CARMAN
AB This paper investigates the possibility that some aggregate gradations could be considered functionally pervious', based on comparison of an aggregate's permeability with either natural soil permeabilities or local rainfall intensities. Permeability was estimated by calculation for 27 American standard gradations, based on their porosity, coefficient of uniformity and effective particle size. In addition aggregate's cost relative to other urban surfaces was estimated. The results show that gradations of ASTM D448 No. 9, 89 and larger have high permeabilities relative to both the most permeable soil and the most intense rainfall in the central and eastern United States and so could be considered pervious surfaces in that large region. Denser gradations have lower permeabilities and less claim to be considered pervious. Properly selected aggregate's combination of high permeability and low cost make it an attractive option for reducing impervious cover, under the detailed traffic types for which it is suited.
C1 [Ferguson, Bruce K.] Univ Georgia, Coll Environm & Design, Athens, GA 30602 USA.
[Ferguson, Benjamin K.] Paul C Rizzo Associates, Pittsburgh, PA USA.
[Mickalonis, Olivia] USA, Directorate Publ Works, Ft Stewart, GA USA.
RP Ferguson, BK (reprint author), Univ Georgia, Coll Environm & Design, Athens, GA 30602 USA.
EM bfergus@uga.edu
NR 28
TC 0
Z9 0
U1 2
U2 7
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1573-062X
J9 URBAN WATER J
JI Urban Water J.
PD FEB 1
PY 2013
VL 10
IS 1
BP 62
EP 69
DI 10.1080/1573062X.2012.682592
PG 8
WC Water Resources
SC Water Resources
GA 093LM
UT WOS:000315193400005
ER
PT J
AU Gottfried, JL
AF Gottfried, Jennifer L.
TI Influence of metal substrates on the detection of explosive residues
with laser-induced breakdown spectroscopy
SO APPLIED OPTICS
LA English
DT Article
ID ORGANIC-COMPOUNDS; CLASSIFICATION; ABLATION; PLASMA; DISCRIMINATION;
SPECTRA; RDX
AB Laser-induced breakdown spectroscopy is a promising approach for explosive residue detection, but several limitations to its widespread use remain. One issue is that the emission spectra of the residues are dependent on the substrate composition because some of the substrate is usually entrained in the laser-induced plasma and the laser-material interaction can be significantly affected by the substrate type. Here, we have demonstrated that despite the strong spectral variation in cyclotrimethylenetrinitramine (RDX) residues applied to various metal substrates, classification of the RDX residue independent of substrate type is feasible. Several approaches to improving the chemometric models based on partial least squares discriminant analysis (PLS-DA) have been described: classifying the RDX residue spectra together in one class independent of substrate, using selected emission intensities and ratios to increase the true positive rate (TPR) and decrease the false positive rate (FPR), and fusing the results from two PLS-DA models generated using the full broadband spectra and selected intensities and ratios. The combination of these approaches resulted in a TPR of 97.5% and a FPR of 1.0% for RDX classification on metal substrates.
C1 USA, Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA.
RP Gottfried, JL (reprint author), USA, Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA.
EM jennifer.gottfried@us.army.mil
RI Gottfried, Jennifer/G-6333-2010
NR 31
TC 12
Z9 13
U1 2
U2 31
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1559-128X
EI 2155-3165
J9 APPL OPTICS
JI Appl. Optics
PD FEB 1
PY 2013
VL 52
IS 4
BP B10
EP B19
DI 10.1364/AO.52.000B10
PG 10
WC Optics
SC Optics
GA 086LH
UT WOS:000314684600003
PM 23385936
ER
PT J
AU McLurkin, J
Rykowski, J
John, M
Kaseman, Q
Lynch, AJ
AF McLurkin, James
Rykowski, Joshua
John, Meagan
Kaseman, Quillan
Lynch, Andrew J.
TI Using Multi-Robot Systems for Engineering Education: Teaching and
Outreach With Large Numbers of an Advanced, Low-Cost Robot
SO IEEE TRANSACTIONS ON EDUCATION
LA English
DT Article
DE Engineering; multi-robot systems; problem-based learning; outreach;
robotics education
AB This paper describes the experiences of using an advanced, low-cost robot in science, technology, engineering, and mathematics (STEM) education. It presents three innovations: It is a powerful, cheap, robust, and small advanced personal robot; it forms the foundation of a problem-based learning curriculum; and it enables a novel multi-robot curriculum while fostering collaborative team work on assignments. The robot design has many features specific to educators: It is advanced enough for academic research, has a broad feature set to support a wide range of curricula, and is inexpensive enough to be an effective outreach tool. The low cost allows each student to have their own robot for the semester, so they can work on activities outside the classroom. This robot was used in three different classes in which it was the foundation for an innovative problem-based learning curriculum. In particular, the robot has specialized sensors and a communications system that supports novel multi-robot curricula, which encourage student interaction in new ways. The results are promising; the robot was a big success in graduate, undergraduate, and outreach activities. Finally, student assessments indicate a greater interest and understanding of engineering and other STEM majors, and class evaluations were consistently above average.
C1 [McLurkin, James; John, Meagan; Kaseman, Quillan; Lynch, Andrew J.] Rice Univ, Dept Comp Sci, Houston, TX 77005 USA.
[Rykowski, Joshua] US Mil Acad, Dept Comp Sci, West Point, NY 10996 USA.
RP McLurkin, J (reprint author), Rice Univ, Dept Comp Sci, Houston, TX 77005 USA.
EM jmclurkin@rice.edu; joshua.rykowski@usma.edu; maj5@rice.edu;
quillan.t.kaseman@rice.edu; lyncas@gmail.com
NR 35
TC 22
Z9 22
U1 8
U2 59
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-9359
J9 IEEE T EDUC
JI IEEE Trans. Educ.
PD FEB
PY 2013
VL 56
IS 1
SI SI
BP 24
EP 33
DI 10.1109/TE.2012.2222646
PG 10
WC Education, Scientific Disciplines; Engineering, Electrical & Electronic
SC Education & Educational Research; Engineering
GA 088JI
UT WOS:000314829800005
ER
PT J
AU Gonzalez, RR
Kenefick, RW
Muza, SR
Hamilton, SW
Sawka, MN
AF Gonzalez, Richard R.
Kenefick, Robert W.
Muza, Stephen R.
Hamilton, Scott W.
Sawka, Michael N.
TI Sweat rate and prediction validation during high-altitude treks on Mount
Kilimanjaro
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE solar load; hypobaric environments; water requirements; modeling
prediction analyses
ID HEAT-STRESS; EXERCISE PERFORMANCE; ENERGY-EXPENDITURE; WATER NEEDS;
TEMPERATURE; MECHANISMS; EXPOSURE; HYPOHYDRATION; ENVIRONMENTS;
DEHYDRATION
AB Gonzalez RR, Kenefick RW, Muza SR, Hamilton SW, Sawka MN. Sweat rate and prediction validation during high-altitude treks on Mount Kilimanjaro. J Appl Physiol 114: 436-443, 2013. First published December 27, 2012; doi: 10.1152/japplphysiol.01176.2012.This study measured sweat rates (m(sw)) during high-altitude summer treks on Mt. Kilimanjaro to evaluate the efficacy of a recently developed fuzzy piecewise sweat prediction equation ((P) over dotw,sol) for application to high-altitude conditions. We hypothesized that the (P) over dotw,sol equation, adjusted for the barometric pressure (P-B) decreasing steadily at high altitude ((P) over dotw,sol + Alt), would allow for a more accurate prediction of msw than (P) over dotw,sol unadjusted for altitude ((P) over dotw,sol(SL)). Fifteen men (43 +/- 16 yr; 80 +/- 22 kg) and seven women (46 +/- 16 yr; 77 +/- 18 kg) wearing hiking clothes (clo similar to 1.15; clothing evaporative potential = 0.27) and carrying light loads (9 +/- 2 kg), were studied during morning and afternoon treks (similar to 2-3 h) while ascending from 2,829 m to 3,505 m. After each trek, msw was measured with specific biophysical parameters at 15-min intervals. During the trek day, P-B progressively declined (530 to 504 Torr), as solar radiation and ambient temperature (degrees C) rose transiently. During all treks, msw ranged from 68 to 393 g.m(-2).h(-1) (0.14 to 0.79 l/h). For each subject, derived (P) over dotw,sol(SL) and (P) over dotw,sol+Alt model outputs accurately predicted the morning and afternoon average m(sw) within a root mean square error of 0.145 l/h. No differences were found between (P) over dotw, sol(SL) and (P) over dotw,sol+Alt values. In conclusion, we report the first msw measured during outdoor high-altitude activities and determined that (P) over dotw,sol(SL) equation can be used to predict fluid needs during high-altitude activities without alterations for lower P-B. This model prediction provides a valid water planning tool for outdoor activities at high altitude up to 3,500 m.
C1 [Gonzalez, Richard R.] New Mexico State Univ, Dept Biol, Las Cruces, NM 88003 USA.
[Kenefick, Robert W.; Muza, Stephen R.; Hamilton, Scott W.; Sawka, Michael N.] USA, Environm Med Res Inst, Natick, MA 01760 USA.
RP Kenefick, RW (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St, Natick, MA 01760 USA.
EM robert.kenefick@us.army.mil
FU US Army Medical Research and Material Command
FX This study was a flag expedition of The Explorers Club, New York City,
NY, and funding was provided by the US Army Medical Research and
Material Command.
NR 36
TC 3
Z9 3
U1 1
U2 19
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 8750-7587
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD FEB
PY 2013
VL 114
IS 4
BP 436
EP 443
DI 10.1152/japplphysiol.01176.2012
PG 8
WC Physiology; Sport Sciences
SC Physiology; Sport Sciences
GA 092KA
UT WOS:000315118300002
PM 23271696
ER
PT J
AU Estrada, AX
Dirosa, GA
Decostanza, AH
AF Estrada, Armando X.
Dirosa, Gia A.
Decostanza, Arwen H.
TI Gays in the U.S. Military: Reviewing the Research and Conceptualizing a
Way Forward
SO JOURNAL OF HOMOSEXUALITY
LA English
DT Article
DE gays; sexual orientation; military service; Don't Ask Don't Tell; DADT
ID WORKPLACE SEXUAL-HARASSMENT; INTERGROUP CONTACT; BENEVOLENT SEXISM; MERE
EXPOSURE; HETEROSEXUALS ATTITUDES; WOMEN; METAANALYSIS; PERFORMANCE;
DISCLOSURE; PERSONNEL
AB This article contributes to ongoing discussions related to the challenges and opportunities associated with the participation and inclusion of openly gay service personnel within the U.S. military. The article reviews research related to sexual orientation and military service and outlines a theory of the antecedents and outcomes of open integration of gays in the military environment. We discuss implications of this theory for future research in this area.
C1 [Estrada, Armando X.; Dirosa, Gia A.; Decostanza, Arwen H.] USA, Res Inst Behav & Social Sci, Aberdeen Proving Ground, MD 21005 USA.
RP Estrada, AX (reprint author), USA, Res Inst, Fdn Sci Res Unit DAPE ARI FS, 6010 Frankford St,Off 221, Aberdeen Proving Ground, MD 21005 USA.
EM aestrada1@vancouver.wsu.edu
NR 103
TC 2
Z9 2
U1 2
U2 14
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0091-8369
J9 J HOMOSEXUAL
JI J. Homosex.
PD FEB 1
PY 2013
VL 60
IS 2-3
SI SI
BP 327
EP 355
DI 10.1080/00918369.2013.744676
PG 29
WC Psychology, Multidisciplinary; Social Sciences, Interdisciplinary
SC Psychology; Social Sciences - Other Topics
GA 089NL
UT WOS:000314917200011
PM 23414276
ER
PT J
AU Poret, JC
Shaw, AP
Csernica, CM
Oyler, KD
Estes, DP
AF Poret, Jay C.
Shaw, Anthony P.
Csernica, Christopher M.
Oyler, Karl D.
Estes, Deven P.
TI Development and Performance of the W/Sb2O3/KIO4/Lubricant Pyrotechnic
Delay in the US Army Hand-Held Signal
SO PROPELLANTS EXPLOSIVES PYROTECHNICS
LA English
DT Article
DE Pyrotechnic delays; Tungsten; Periodate; Hand-held signal
AB Gassy pyrotechnic delays composed of tungsten, antimony(III) oxide, potassium periodate, and various lubricants have been developed for use in the US Army hand-held signal. The new compositions were developed to replace the current formulation, which contains potassium perchlorate and barium chromate, chemicals that are facing increasing scrutiny due to environmental regulation. The hand-held signal delay housing was used to demonstrate the burning rate tunability of the new compositions. The addition of 15% of waxy lubricants (stearic acid or calcium stearate) was found to have a profound effect on burning rate. The effect of tungsten content and the Sb2O3/KIO4 ratio on burning rate was also probed. A wide range of inverse burning rates (2 to 15scm1) were demonstrated, which encompasses the 7 to 8.5scm1 range required by the hand-held signal. The W/KIO4 reaction produces I2, which was observed by visible spectroscopy in the vapor above a sample of combustion residue.
C1 [Poret, Jay C.; Shaw, Anthony P.; Csernica, Christopher M.] US Army, RDECOM ARDEC, Pyrotech Technol & Prototyping Div, Picatinny Arsenal, NJ 07806 USA.
[Oyler, Karl D.] US Army, RDECOM ARDEC, Explos Technol & Prototyping Div, Picatinny Arsenal, NJ 07806 USA.
[Estes, Deven P.] Columbia Univ, Dept Chem, New York, NY 10027 USA.
RP Poret, JC (reprint author), US Army, RDECOM ARDEC, Pyrotech Technol & Prototyping Div, Picatinny Arsenal, NJ 07806 USA.
EM anthony.p.shaw.civ@mail.mil
FU US Army through the Environmental Quality Technology (EQT) Program
FX The authors thank the US Army for funding this project through the
Environmental Quality Technology (EQT) Program.
NR 25
TC 12
Z9 12
U1 0
U2 7
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY
SN 0721-3115
J9 PROPELL EXPLOS PYROT
JI Propellants Explos. Pyrotech.
PD FEB
PY 2013
VL 38
IS 1
BP 35
EP 40
DI 10.1002/prep.201200109
PG 6
WC Chemistry, Applied; Engineering, Chemical
SC Chemistry; Engineering
GA 090QO
UT WOS:000314994200005
ER
PT J
AU Ioannou, A
Lieberman, LA
Lucca, JJD
Tsokos, GC
AF Ioannou, Antonis
Lieberman, Linda A.
Lucca, Jurandir J. Dalle
Tsokos, George C.
TI Complement depletion protects lupus-prone mice from
ischemia-reperfusion-initiated organ injury
SO AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
LA English
DT Article
DE ischemia-reperfusion injury; intestine; complement; systemic lupus
erythematosus
ID ISCHEMIA/REPERFUSION-INDUCED INJURY; LUNG-TISSUE DAMAGE; COBRA VENOM
FACTOR; MYOCARDIAL-ISCHEMIA; BINDING LECTIN; 2 PARTS; C5A;
ERYTHEMATOSUS; ACTIVATION; HEMORRHAGE
AB Ioannou A, Lieberman LA, Dalle Lucca JJ, Tsokos GC. Complement depletion protects lupus-prone mice from ischemia-reperfusion-initiated organ injury. Am J Physiol Gastrointest Liver Physiol 304: G283-G292, 2013. First published October 25, 2012; doi:10.1152/ajpgi.00371.2012.-Ischemia-reperfusion (IR) injury causes a vigorous immune response that is amplified by complement activation, leading to local and remote tissue damage. Using MRL/lpr mice, which are known to experience accelerated tissue damage after mesenteric IR injury, we sought to evaluate whether complement inhibition mitigates organ damage. We found that complement depletion with cobra venom factor protected mice from local and remote lung tissue damage. Protection from injury was associated with less complement (C3) and membrane attack complex deposition, less neutrophil infiltration, and lower levels of local proinflammatory cytokine production. In addition, complement depletion was able to decrease the level of oxidative stress as measured by glutathione peroxidase 1 mRNA levels and superoxide dismutase activity. Furthermore, blockage of C5a receptor protected MRL/lpr mice from local tissue damage, but not from remote lung tissue damage. In conclusion, although treatments with cobra venom factor and C5a receptor antagonist were able to protect mice from local tissue damage, treatment with C5a receptor antagonist was not able to protect mice from remote lung tissue damage, implying that more factors contribute to the development of remote tissue damage after IR injury. These data also suggest that complement inhibition at earlier, rather than late, stages can have clinical benefit in conditions that are complicated with IR injury.
C1 [Ioannou, Antonis; Lieberman, Linda A.; Tsokos, George C.] Beth Israel Deaconess Med Ctr, Div Rheumatol, Boston, MA 02215 USA.
[Ioannou, Antonis; Lieberman, Linda A.; Tsokos, George C.] Harvard Univ, Sch Med, Boston, MA 02115 USA.
[Lucca, Jurandir J. Dalle] USA, Inst Surg Res, San Antonio, TX USA.
[Ioannou, Antonis] Univ Crete, Sch Med, Dept Basic Sci, Iraklion, Crete, Greece.
RP Ioannou, A (reprint author), Harvard Univ, Beth Israel Deaconess Med Ctr, Dept Med, Div Rheumatol,Med Sch, 330 Brookline Ave,CLS 928, Boston, MA 02115 USA.
EM aioannou@bidmc.harvard.edu
FU US Army Medical Research and Material Command [W81XWH-09-1-0530,
W81XWH-09-1-0536]
FX The research presented here was supported by US Army Medical Research
and Material Command Grants W81XWH-09-1-0530 and W81XWH-09-1-0536.
NR 57
TC 3
Z9 3
U1 0
U2 6
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1857
J9 AM J PHYSIOL-GASTR L
JI Am. J. Physiol.-Gastroint. Liver Physiol.
PD FEB
PY 2013
VL 304
IS 3
BP G283
EP G292
DI 10.1152/ajpgi.00371.2012
PG 10
WC Gastroenterology & Hepatology; Physiology
SC Gastroenterology & Hepatology; Physiology
GA 085WI
UT WOS:000314644600007
PM 23104558
ER
PT J
AU Grogl, M
Hickman, M
Ellis, W
Hudson, T
Lazo, JS
Sharlow, ER
Johnson, J
Berman, J
Sciotti, RJ
AF Grogl, Max
Hickman, Mark
Ellis, William
Hudson, Thomas
Lazo, John S.
Sharlow, Elizabeth R.
Johnson, Jacob
Berman, Jonathan
Sciotti, Richard J.
TI Review: Drug Discovery Algorithm for Cutaneous Leishmaniasis
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Review
ID HIGH-THROUGHPUT; IDENTIFICATION; AMASTIGOTES; DISEASE; SCREEN
AB Cutaneous leishmaniasis is clinically widespread but lacks treatments that are effective and well tolerated. Because all present drugs have been grandfathered into clinical use, there are no examples of a pre-clinical product evaluation scheme that lead to new candidates for formal development. To provide oral agents for development targeting cutaneous leishmaniasis, we have implemented a discovery scheme that incorporates in vitro and in vivo testing of efficacy, toxicity, and pharmacokinetics/metabolism. Particular emphasis is placed on in vivo testing, progression from higher-throughput models to those with most clinical relevance, and efficient use of resources.
C1 [Grogl, Max; Hickman, Mark; Ellis, William; Hudson, Thomas; Johnson, Jacob; Berman, Jonathan; Sciotti, Richard J.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA.
Univ Pittsburgh, Dept Pharmacol & Chem Biol, Pittsburgh, PA USA.
Univ Virginia, Dept Pharmacol & Chem, Charlottesville, VA USA.
RP Sciotti, RJ (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA.
EM max.grogll@us.army.mil; mark.r.hickman@us.army.mil;
bill.ellis@us.army.mil; thomas.hudson@us.army.mil; jjohnson@wrp-ksm.org;
ers7g@virginia.edu; jsl8f@hscmail.mcc.virginia.edu; jbe9320457@aol.com;
richard.sciotti@us.army.mil
RI Sciotti, Richard/A-9069-2011; Hudson, Thomas/A-9152-2011
NR 19
TC 11
Z9 12
U1 1
U2 14
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD FEB
PY 2013
VL 88
IS 2
BP 216
EP 221
DI 10.4269/ajtmh.11-0812
PG 6
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 082ZG
UT WOS:000314431900003
PM 23390221
ER
PT J
AU Grubaugh, ND
Petz, LN
Melanson, VR
McMenamy, SS
Turell, MJ
Long, LS
Pisarcik, SE
Kengluecha, A
Jaichapor, B
O'Guinn, ML
Lee, JS
AF Grubaugh, Nathan D.
Petz, Lawrence N.
Melanson, Vanessa R.
McMenamy, Scott S.
Turell, Michael J.
Long, Lewis S.
Pisarcik, Sarah E.
Kengluecha, Ampornpan
Jaichapor, Boonsong
O'Guinn, Monica L.
Lee, John S.
TI Evaluation of a Field-Portable DNA Microarray Platform and Nucleic Acid
Amplification Strategies for the Detection of Arboviruses, Arthropods,
and Bloodmeals
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID ELECTROCHEMICAL DETECTION; MOLECULAR-IDENTIFICATION; VIRUS
IDENTIFICATION; PCR; MOSQUITOS; FLAVIVIRUSES; PATHOGENS; TRANSMISSION;
CULICIDAE; INFLUENZA
AB Highly multiplexed assays, such as microarrays, can benefit arbovirus surveillance by allowing researchers to screen for hundreds of targets at once. We evaluated amplification strategies and the practicality of a portable DNA microarray platform to analyze virus-infected mosquitoes. The prototype microarray design used here targeted the nonstructural protein 5, ribosomal RNA, and cytochrome b genes for the detection of flaviviruses, mosquitoes, and bloodmeals, respectively. We identified 13 of 14 flaviviruses from virus inoculated mosquitoes and cultured cells. Additionally, we differentiated between four mosquito genera and eight whole blood samples. The microarray platform was field evaluated in Thailand and successfully identified flaviviruses (Culex flavivirus, dengue-3, and Japanese encephalitis viruses), differentiated between mosquito genera (Aedes, Armigeres, Culex, and Mansonia), and detected mammalian bloodmeals (human and dog). We showed that the microarray platform and amplification strategies described here can be used to discern specific information on a wide variety of viruses and their vectors.
C1 USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA.
[Kengluecha, Ampornpan; Jaichapor, Boonsong] US Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok, Thailand.
RP Lee, JS (reprint author), USA, Med Res & Mat Command, Mil Infect Dis Res Program, Bldg 722,504 Scott Ave, Frederick, MD 21702 USA.
EM nathan.grubaugh@colostate.edu; lawrence.petz@us.army.mil;
vanessa.melanson@us.army.mil; scott.mcmenamy@us.army.mil;
michael.j.turell@us.army.mil; lewis.s.long@us.army.mil;
sarah.pisarcik@us.army.mil; ampornpank@afrims.org; boonsongj@afrims.org;
monica.oguinn@us.amiy.mil; john.s.lee@us.army.mil
FU Military Infectious Disease Research Program project [U0176_09_RD]
FX This research was funded by the Military Infectious Disease Research
Program project no. U0176_09_RD and supported in part by an appointment
to the Postgraduate Research Participation Program at USAMRIID
administered by the Oak Ridge Institute for Science and Education
through an interagency agreement between the U.S. Department of Energy
and U.S. Army Medical Research and Material Command.
NR 35
TC 6
Z9 6
U1 0
U2 29
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD FEB
PY 2013
VL 88
IS 2
BP 245
EP 253
DI 10.4269/ajtmh.2012.12-0048
PG 9
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 082ZG
UT WOS:000314431900009
PM 23249687
ER
PT J
AU Butler, LK
Ries, L
Bisson, IA
Hayden, TJ
Wikelski, MM
Romero, LM
AF Butler, L. K.
Ries, L.
Bisson, I. -A.
Hayden, T. J.
Wikelski, M. M.
Romero, L. M.
TI Opposite but analogous effects of road density on songbirds with
contrasting habitat preferences
SO ANIMAL CONSERVATION
LA English
DT Article
DE edge effects; glucocorticoids; habitat fragmentation; roads; stress
ID CORTICOSTERONE LEVELS; PIED FLYCATCHER; BEHAVIORAL NEUROENDOCRINOLOGY;
ADRENOCORTICAL-RESPONSE; TERRITORIAL BEHAVIOR; REPRODUCTIVE SUCCESS;
PHYSIOLOGICAL STRESS; HORMONAL RESPONSES; SEASONAL-CHANGES; FOREST
AB Roads are a widespread and growing form of habitat alteration, making their effects on wildlife a major conservation concern. We investigated effects of roads on occupancy patterns and stress physiology of the golden-cheeked warbler Setophaga chrysoparia, an endangered songbird that depends on large tracts of old-growth forest for breeding. We compared those effects in the white-eyed vireo Vireo griseus, a common songbird that prefers to breed in scrubby habitat that is common along forest roads. In warblers, older, socially dominant males were more likely to occupy territories, but had higher baseline plasma concentrations of corticosterone, in less-roaded habitats. In vireos, older males were equally likely to occupy territories, but, opposite to warblers, had lower baseline corticosterone concentrations, in less-roaded habitats. In both species, the corticosterone response to acute stress was unrelated to road density, and body condition and fat stores either increased or were sustained across road density groups during the breeding season, suggesting that breeding near roads did not cause chronic stress. Our results suggest that roads can cause increased malemale competition for territories in nearby roadless habitat, and may result in higher corticosterone concentrations in dominant individuals defending preferred sites near or far from edge, depending on species habitat preferences. Increased competition and chronically elevated corticosterone levels may be of concern if they alter parental care or immunity of individuals breeding in the best habitat.
C1 [Butler, L. K.; Romero, L. M.] Coll New Jersey, Dept Biol, Ewing, NJ 08628 USA.
[Ries, L.] Univ Maryland, Dept Biol, College Pk, MD 20742 USA.
[Bisson, I. -A.; Wikelski, M. M.] Princeton Univ, Dept Ecol & Evolutionary Biol, Princeton, NJ 08544 USA.
[Hayden, T. J.] Engn Res & Dev Ctr, Champaign, IL USA.
RP Butler, LK (reprint author), Coll New Jersey, Dept Biol, 2000 Pennington Rd, Ewing, NJ 08628 USA.
EM lbutler@tcnj.edu
FU Strategic Environmental Research and Development Program [SI-1396,
SI-1597]
FX Funding was provided by the Strategic Environmental Research and
Development Program (SI-1396 and SI-1597), but does not necessarily
reflect the position or views of the US government. Roads and trails
were digitized by A. Doherty. Imagery was received from M. Noble of The
Nature Conservancy at Ft. Hood. E. Gill made distinguished contributions
to the field work. L. Glassman, J. Ferrer, M. Vinson, and A. Whitley
also assisted with field experiments. M. Dickens and N. Cyr assisted
with assays, and J. Reed assisted with statistics. Two anonymous
reviewers made suggestions that improved the manuscript.
NR 60
TC 2
Z9 2
U1 3
U2 53
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1367-9430
J9 ANIM CONSERV
JI Anim. Conserv.
PD FEB
PY 2013
VL 16
IS 1
BP 77
EP 85
DI 10.1111/j.1469-1795.2012.00576.x
PG 9
WC Biodiversity Conservation; Ecology
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA 079LJ
UT WOS:000314171600011
ER
PT J
AU Drezner, JA
Ackerman, MJ
Anderson, J
Ashley, E
Asplund, CA
Baggish, AL
Borjesson, M
Cannon, BC
Corrado, D
DiFiori, JP
Fischbach, P
Froelicher, V
Harmon, KG
Heidbuchel, H
Marek, J
Owens, DS
Paul, S
Pelliccia, A
Prutkin, JM
Salerno, JC
Schmied, CM
Sharma, S
Stein, R
Vetter, VL
Wilson, MG
AF Drezner, Jonathan A.
Ackerman, Michael John
Anderson, Jeffrey
Ashley, Euan
Asplund, Chad A.
Baggish, Aaron L.
Borjesson, Mats
Cannon, Bryan C.
Corrado, Domenico
DiFiori, John P.
Fischbach, Peter
Froelicher, Victor
Harmon, Kimberly G.
Heidbuchel, Hein
Marek, Joseph
Owens, David S.
Paul, Stephen
Pelliccia, Antonio
Prutkin, Jordan M.
Salerno, Jack C.
Schmied, Christian M.
Sharma, Sanjay
Stein, Ricardo
Vetter, Victoria L.
Wilson, Mathew G.
TI Electrocardiographic interpretation in athletes: the 'Seattle Criteria'
SO BRITISH JOURNAL OF SPORTS MEDICINE
LA English
DT Article
ID ECG INTERPRETATION; ACCURACY
AB Sudden cardiac death (SCD) is the leading cause of death in athletes during sport. Whether obtained for screening or diagnostic purposes, an ECG increases the ability to detect underlying cardiovascular conditions that may increase the risk for SCD. In most countries, there is a shortage of physician expertise in the interpretation of an athlete's ECG. A critical need exists for physician education in modern ECG interpretation that distinguishes normal physiological adaptations in athletes from abnormal findings suggestive of pathology. On 13-14 February 2012, an international group of experts in sports cardiology and sports medicine convened in Seattle, Washington, to define contemporary standards for ECG interpretation in athletes. The objective of the meeting was to develop a comprehensive training resource to help physicians distinguish normal ECG alterations in athletes from abnormal ECG findings that require additional evaluation for conditions associated with SCD.
C1 [Drezner, Jonathan A.; Harmon, Kimberly G.] Univ Washington, Dept Family Med, Seattle, WA 98195 USA.
[Ackerman, Michael John] Mayo Clin, Dept Med, Div Cardiovasc Dis, Rochester, MN USA.
[Ackerman, Michael John] Mayo Clin, Dept Pediat, Div Cardiovasc Dis, Rochester, MN USA.
[Ackerman, Michael John] Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Div Cardiovasc Dis, Rochester, MN USA.
[Ackerman, Michael John] Mayo Clin, Div Pediat Cardiol, Rochester, MN USA.
[Anderson, Jeffrey] Univ Connecticut, Dept Athlet, Storrs, CT USA.
[Ashley, Euan; Froelicher, Victor] Stanford Univ, Sch Med, Div Cardiovasc Med, Palo Alto, CA 94304 USA.
[Asplund, Chad A.] Eisenhower Army Med Ctr, Dept Family Med, Ft Gordon, GA USA.
[Baggish, Aaron L.] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA.
[Borjesson, Mats] Karolinska Univ Hosp, Swedish Sch Sports & Hlth Sci, Dept Cardiol, Stockholm, Sweden.
[Cannon, Bryan C.] Mayo Clin, Div Cardiovasc Dis, Rochester, MN USA.
[Corrado, Domenico] Univ Padua, Dept Cardiac Thorac & Vasc Sci, Padua, Italy.
[DiFiori, John P.] Univ Calif Los Angeles, Dept Family Med, Div Sports Med, Los Angeles, CA USA.
[Fischbach, Peter] Emory Univ, Sch Med, Dept Pediat, Childrens Healthcare Atlanta, Atlanta, GA USA.
[Heidbuchel, Hein] Univ Louvain, Dept Cardiovasc Sci, Louvain, Belgium.
[Marek, Joseph] Midwest Heart Fdn, Oak Brook Terrace, IL USA.
[Owens, David S.; Prutkin, Jordan M.] Univ Washington, Div Cardiol, Seattle, WA 98195 USA.
[Paul, Stephen] Univ Arizona, Dept Family & Community Med, Tucson, AZ USA.
[Pelliccia, Antonio] Inst Sport Med & Sci, Dept Med, Rome, Italy.
[Salerno, Jack C.] Seattle Childrens Hosp, Div Cardiol, Seattle, WA USA.
[Schmied, Christian M.] Univ Zurich Hosp, Ctr Cardiovasc, Div Cardiol, CH-8091 Zurich, Switzerland.
[Sharma, Sanjay] St Georges Univ London, Dept Cardivasc Sci, London, England.
[Stein, Ricardo] Hosp Clin Porto Alegre, Dept Cardiol, Porto Alegre, RS, Brazil.
[Vetter, Victoria L.] Childrens Hosp Philadelphia, Div Cardiol, Philadelphia, PA 19104 USA.
[Wilson, Mathew G.] Qatar Orthoped & Sports Med Hosp, ASPETAR, Dept Sports Med, Doha, Qatar.
RP Drezner, JA (reprint author), Univ Washington, Dept Family Med, 1959 NE Pacific St,Box 356390, Seattle, WA 98195 USA.
EM jdrezner@uw.edu
OI Borjesson, Mats/0000-0002-8786-0438; Owens, David/0000-0002-7293-9688
NR 11
TC 166
Z9 169
U1 4
U2 34
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0306-3674
J9 BRIT J SPORT MED
JI Br. J. Sports Med.
PD FEB
PY 2013
VL 47
IS 3
BP 122
EP 124
DI 10.1136/bjsports-2012-092067
PG 3
WC Sport Sciences
SC Sport Sciences
GA 081VE
UT WOS:000314349700002
PM 23303758
ER
PT J
AU Drezner, JA
Fischbach, P
Froelicher, V
Marek, J
Pelliccia, A
Prutkin, JM
Schmied, CM
Sharma, S
Wilson, MG
Ackerman, MJ
Anderson, J
Ashley, E
Asplund, CA
Baggish, AL
Borjesson, M
Cannon, BC
Corrado, D
DiFiori, JP
Harmon, KG
Heidbuchel, H
Owens, DS
Paul, S
Salerno, JC
Stein, R
Vetter, VL
AF Drezner, Jonathan A.
Fischbach, Peter
Froelicher, Victor
Marek, Joseph
Pelliccia, Antonio
Prutkin, Jordan M.
Schmied, Christian M.
Sharma, Sanjay
Wilson, Mathew G.
Ackerman, Michael John
Anderson, Jeffrey
Ashley, Euan
Asplund, Chad A.
Baggish, Aaron L.
Borjesson, Mats
Cannon, Bryan C.
Corrado, Domenico
DiFiori, John P.
Harmon, Kimberly G.
Heidbuchel, Hein
Owens, David S.
Paul, Stephen
Salerno, Jack C.
Stein, Ricardo
Vetter, Victoria L.
TI Normal electrocardiographic findings: recognising physiological
adaptations in athletes
SO BRITISH JOURNAL OF SPORTS MEDICINE
LA English
DT Article
ID EARLY REPOLARIZATION PATTERN; HYPERTROPHIC CARDIOMYOPATHY;
CLINICAL-SIGNIFICANCE; ECG; PREVALENCE; HEART; CRITERIA; POPULATION;
CARDIOLOGY; CONDUCTION
AB Electrocardiographic changes in athletes are common and usually reflect benign structural and electrical remodelling of the heart as a physiological adaptation to regular and sustained physical training (athlete's heart). The ability to identify an abnormality on the 12-lead ECG, suggestive of underlying cardiac disease associated with sudden cardiac death (SCD), is based on a sound working knowledge of the normal ECG characteristics within the athletic population. This document will assist physicians in identifying normal ECG patterns commonly found in athletes. The ECG findings presented as normal in athletes were established by an international consensus panel of experts in sports cardiology and sports medicine.
C1 [Drezner, Jonathan A.; Fischbach, Peter; Harmon, Kimberly G.] Univ Washington, Dept Family Med, Seattle, WA 98195 USA.
[Fischbach, Peter] Emory Univ, Sch Med, Dept Pediat, Childrens Healthcare Atlanta, Atlanta, GA USA.
[Froelicher, Victor; Ashley, Euan] Stanford Univ, Sch Med, Div Cardiovasc Med, Palo Alto, CA 94304 USA.
[Marek, Joseph] Midwest Heart Fdn, Oak Brook Terrace, IL USA.
[Pelliccia, Antonio] Inst Sport Med & Sci, Dept Med, Rome, Italy.
[Prutkin, Jordan M.; Owens, David S.] Univ Washington, Div Cardiol, Seattle, WA 98195 USA.
[Schmied, Christian M.] Univ Zurich Hosp, Div Cardiol, CH-8091 Zurich, Switzerland.
[Sharma, Sanjay] St Georges Univ London, Dept Cardivasc Sci, London, England.
[Wilson, Mathew G.] Qatar Orthoped & Sports Med Hosp, ASPETAR, Dept Sports Med, Doha, Qatar.
[Ackerman, Michael John] Mayo Clin, Dept Med, Div Cardiovasc Dis, Rochester, MN USA.
[Ackerman, Michael John] Mayo Clin, Dept Med, Dept Pediat Cardiol, Rochester, MN USA.
[Ackerman, Michael John] Mayo Clin, Dept Pediat, Rochester, MN USA.
[Ackerman, Michael John] Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN USA.
[Anderson, Jeffrey] Univ Connecticut, Dept Athlet, Storrs, CT USA.
[Asplund, Chad A.] Eisenhower Army Med Ctr, Dept Family Med, Ft Gordon, GA USA.
[Baggish, Aaron L.] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA.
[Borjesson, Mats] Karolinska Univ Hosp, Swedish Sch Sports & Hlth Sci, Dept Cardiol, Stockholm, Sweden.
[Cannon, Bryan C.] Mayo Clin, Div Cardiovasc Dis, Rochester, MN USA.
[Corrado, Domenico] Univ Padua, Dept Cardiac Thorac & Vasc Sci, Padua, Italy.
[DiFiori, John P.] Univ Calif Los Angeles, Div Sports Med, Los Angeles, CA USA.
[Heidbuchel, Hein] Univ Louvain, Dept Cardiovasc Sci, Louvain, Belgium.
[Paul, Stephen] Univ Arizona, Dept Family & Community Med, Tucson, AZ USA.
[Salerno, Jack C.] Seattle Childrens Hosp, Div Cardiol, Seattle, WA USA.
[Stein, Ricardo] Hosp Clin Porto Alegre, Dept Cardiol, Porto Alegre, RS, Brazil.
[Vetter, Victoria L.] Childrens Hosp Philadelphia, Div Cardiol, Philadelphia, PA 19104 USA.
RP Drezner, JA (reprint author), Univ Washington, Dept Family Med, 1959 NE Pacific St,Box 356390, Seattle, WA 98195 USA.
EM jdrezner@uw.edu
OI Borjesson, Mats/0000-0002-8786-0438; Owens, David/0000-0002-7293-9688
NR 35
TC 48
Z9 50
U1 0
U2 19
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0306-3674
J9 BRIT J SPORT MED
JI Br. J. Sports Med.
PD FEB
PY 2013
VL 47
IS 3
BP 125
EP +
DI 10.1136/bjsports-2012-092068
PG 13
WC Sport Sciences
SC Sport Sciences
GA 081VE
UT WOS:000314349700003
PM 23303759
ER
PT J
AU Drezner, JA
Ashley, E
Baggish, AL
Borjesson, M
Corrado, D
Owens, DS
Patel, A
Pelliccia, A
Vetter, VL
Ackerman, MJ
Anderson, J
Asplund, CA
Cannon, BC
DiFiori, J
Fischbach, P
Froelicher, V
Harmon, KG
Heidbuchel, H
Marek, J
Paul, S
Prutkin, JM
Salerno, JC
Schmied, CM
Sharma, S
Stein, R
Wilson, M
AF Drezner, Jonathan A.
Ashley, Euan
Baggish, Aaron L.
Borjesson, Mats
Corrado, Domenico
Owens, David S.
Patel, Akash
Pelliccia, Antonio
Vetter, Victoria L.
Ackerman, Michael J.
Anderson, Jeff
Asplund, Chad A.
Cannon, Bryan C.
DiFiori, John
Fischbach, Peter
Froelicher, Victor
Harmon, Kimberly G.
Heidbuchel, Hein
Marek, Joseph
Paul, Stephen
Prutkin, Jordan M.
Salerno, Jack C.
Schmied, Christian M.
Sharma, Sanjay
Stein, Ricardo
Wilson, Mathew
TI Abnormal electrocardiographic findings in athletes: recognising changes
suggestive of cardiomyopathy
SO BRITISH JOURNAL OF SPORTS MEDICINE
LA English
DT Article
ID LEFT-VENTRICULAR NONCOMPACTION; PRIMARY PULMONARY-HYPERTENSION;
BUNDLE-BRANCH BLOCK; DISTINGUISHING HYPERTROPHIC CARDIOMYOPATHY;
CARDIOVASCULAR MAGNETIC-RESONANCE; FAMILIAL DILATED CARDIOMYOPATHY;
ST-SEGMENT ELEVATION; SUDDEN-DEATH; NON-COMPACTION; SYSTOLIC DYSFUNCTION
AB Cardiomyopathies are a heterogeneous group of heart muscle diseases and collectively are the leading cause of sudden cardiac death (SCD) in young athletes. The 12-lead ECG is utilised as both a screening and diagnostic tool for detecting conditions associated with SCD. Fundamental to the appropriate evaluation of athletes undergoing ECG is an understanding of the ECG findings that may indicate the presence of an underlying pathological cardiac disorder. This article describes ECG findings present in cardiomyopathies afflicting young athletes and outlines appropriate steps for further evaluation of these ECG abnormalities. The ECG findings defined as abnormal in athletes were established by an international consensus panel of experts in sports cardiology and sports medicine.
C1 [Drezner, Jonathan A.; Harmon, Kimberly G.] Univ Washington, Dept Family Med, Seattle, WA 98195 USA.
[Ashley, Euan; Froelicher, Victor] Stanford Univ, Sch Med, Div Cardiovasc Med, Palo Alto, CA 94304 USA.
[Baggish, Aaron L.] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA.
[Borjesson, Mats] Karolinska Univ Hosp, Swedish Sch Sports & Hlth Sci, Dept Cardiol, Stockholm, Sweden.
[Corrado, Domenico] Univ Padua, Dept Cardiac Thorac & Vasc Sci, Padua, Italy.
[Owens, David S.; Prutkin, Jordan M.] Univ Washington, Div Cardiol, Seattle, WA 98195 USA.
[Patel, Akash; Vetter, Victoria L.] Childrens Hosp Philadelphia, Div Cardiol, Philadelphia, PA 19104 USA.
[Pelliccia, Antonio] Inst Sport Med & Sci, Dept Med, Rome, Italy.
[Ackerman, Michael J.] Mayo Clin, Dept Med, Rochester, MN USA.
[Ackerman, Michael J.] Mayo Clin, Dept Pediat, Rochester, MN USA.
[Ackerman, Michael J.] Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN USA.
[Ackerman, Michael J.; Cannon, Bryan C.] Mayo Clin, Div Cardiovasc Dis, Rochester, MN USA.
[Ackerman, Michael J.] Mayo Clin, Div Pediat Cardiol, Rochester, MN USA.
[Anderson, Jeff] Univ Connecticut, Dept Athlet, Storrs, CT USA.
[Asplund, Chad A.] Eisenhower Army Med Ctr, Dept Family Med, Ft Gordon, GA USA.
[DiFiori, John] Univ Calif Los Angeles, Div Sports Med, Los Angeles, CA USA.
[Fischbach, Peter] Emory Univ, Sch Med, Dept Pediat, Childrens Healthcare Atlanta, Atlanta, GA USA.
[Heidbuchel, Hein] Univ Louvain, Dept Cardiovasc Sci, Louvain, Belgium.
[Marek, Joseph] Midwest Heart Fdn, Oak Brook Terrace, IL USA.
[Paul, Stephen] Univ Arizona, Dept Family & Community Med, Tucson, AZ USA.
[Salerno, Jack C.] Seattle Childrens Hosp, Div Cardiol, Seattle, WA USA.
[Schmied, Christian M.] Univ Zurich Hosp, Div Cardiol, CH-8091 Zurich, Switzerland.
[Sharma, Sanjay] St Georges Univ London, Dept Cardiovasc Sci, London, England.
[Stein, Ricardo] Hosp Clin Porto Alegre, Dept Cardiol, Porto Alegre, RS, Brazil.
[Wilson, Mathew] Qatar Orthoped & Sports Med Hosp, ASPETAR, Dept Sports Med, Doha, Qatar.
RP Drezner, JA (reprint author), Univ Washington, Dept Family Med, 1959 NE Pacific St,Box 356390, Seattle, WA 98195 USA.
EM jdrezner@uw.edu
OI Borjesson, Mats/0000-0002-8786-0438; Owens, David/0000-0002-7293-9688
NR 91
TC 46
Z9 46
U1 0
U2 22
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0306-3674
J9 BRIT J SPORT MED
JI Br. J. Sports Med.
PD FEB
PY 2013
VL 47
IS 3
BP 137
EP +
DI 10.1136/bjsports-2012-092069
PG 18
WC Sport Sciences
SC Sport Sciences
GA 081VE
UT WOS:000314349700004
PM 23303760
ER
PT J
AU Drezner, JA
Ackerman, MJ
Cannon, BC
Corrado, D
Heidbuchel, H
Prutkin, JM
Salerno, JC
Anderson, J
Ashley, E
Asplund, CA
Baggish, AL
Borjesson, M
DiFiori, JP
Fischbach, P
Froelicher, V
Harmon, KG
Marek, J
Owens, DS
Paul, S
Pelliccia, A
Schmied, CM
Sharma, S
Stein, R
Vetter, VL
Wilson, MG
AF Drezner, Jonathan A.
Ackerman, Michael J.
Cannon, Bryan C.
Corrado, Domenico
Heidbuchel, Hein
Prutkin, Jordan M.
Salerno, Jack C.
Anderson, Jeffrey
Ashley, Euan
Asplund, Chad A.
Baggish, Aaron L.
Borjesson, Mats
DiFiori, John P.
Fischbach, Peter
Froelicher, Victor
Harmon, Kimberly G.
Marek, Joseph
Owens, David S.
Paul, Stephen
Pelliccia, Antonio
Schmied, Christian M.
Sharma, Sanjay
Stein, Ricardo
Vetter, Victoria L.
Wilson, Mathew G.
TI Abnormal electrocardiographic findings in athletes: recognising changes
suggestive of primary electrical disease
SO BRITISH JOURNAL OF SPORTS MEDICINE
LA English
DT Article
ID LONG-QT-SYNDROME; PARKINSON-WHITE-SYNDROME; POLYMORPHIC
VENTRICULAR-TACHYCARDIA; SUDDEN UNEXPLAINED DEATH; HEART-RHYTHM-SOCIETY;
PROPOSED DIAGNOSTIC-CRITERIA; EXPERT CONSENSUS STATEMENT; OF-CARDIOLOGY
FOUNDATION; BRUGADA-SYNDROME; CARDIAC DEATH
AB Cardiac channelopathies are potentially lethal inherited arrhythmia syndromes and an important cause of sudden cardiac death (SCD) in young athletes. Other cardiac rhythm and conduction disturbances also may indicate the presence of an underlying cardiac disorder. The 12-lead ECG is utilised as both a screening and a diagnostic tool for detecting conditions associated with SCD. Fundamental to the appropriate evaluation of athletes undergoing ECG is an understanding of the ECG findings that may indicate the presence of a pathological cardiac disease. This article describes ECG findings present in primary electrical diseases afflicting young athletes and outlines appropriate steps for further evaluation of these ECG abnormalities. The ECG findings defined as abnormal in athletes were established by an international consensus panel of experts in sports cardiology and sports medicine.
C1 [Drezner, Jonathan A.; Harmon, Kimberly G.] Univ Washington, Dept Family Med, Seattle, WA 98195 USA.
[Ackerman, Michael J.] Mayo Clin, Dept Med, Rochester, MN USA.
[Ackerman, Michael J.] Mayo Clin, Dept Pediat, Rochester, MN USA.
[Ackerman, Michael J.] Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN USA.
[Ackerman, Michael J.; Cannon, Bryan C.] Mayo Clin, Div Cardiovasc Dis, Rochester, MN USA.
[Ackerman, Michael J.] Mayo Clin, Div Pediat Cardiol, Rochester, MN USA.
[Corrado, Domenico] Univ Padua, Dept Cardiac Thorac & Vasc Sci, Padua, Italy.
[Heidbuchel, Hein] Univ Louvain, Dept Cardiovasc Sci, Louvain, Belgium.
[Prutkin, Jordan M.; Owens, David S.] Univ Washington, Div Cardiol, Seattle, WA 98195 USA.
[Salerno, Jack C.] Seattle Childrens Hosp, Div Cardiol, Seattle, WA USA.
[Anderson, Jeffrey] Univ Connecticut, Dept Athlet, Storrs, CT USA.
[Ashley, Euan; Froelicher, Victor] Stanford Univ, Sch Med, Div Cardiovasc Med, Palo Alto, CA 94304 USA.
[Asplund, Chad A.] Eisenhower Army Med Ctr, Dept Family Med, Ft Gordon, GA USA.
[Baggish, Aaron L.] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA.
[Borjesson, Mats] Karolinska Univ Hosp, Swedish Sch Sports & Hlth Sci, Stockholm, Sweden.
[Borjesson, Mats] Karolinska Univ Hosp, Dept Cardiol, Stockholm, Sweden.
[DiFiori, John P.] Univ Calif Los Angeles, Div Sports Med, Los Angeles, CA USA.
[Fischbach, Peter] Emory Univ, Sch Med, Dept Pediat, Childrens Healthcare Atlanta, Atlanta, GA USA.
[Marek, Joseph] Midwest Heart Fdn, Oak Brook Terrace, IL USA.
[Paul, Stephen] Univ Arizona, Dept Family & Community Med, Tucson, AZ USA.
[Pelliccia, Antonio] Inst Sport Med & Sci, Dept Med, Rome, Italy.
[Schmied, Christian M.] Univ Zurich Hosp, Div Cardiol, CH-8091 Zurich, Switzerland.
[Sharma, Sanjay] St Georges Univ London, Dept Cardiovasc Sci, London, England.
[Stein, Ricardo] Hosp Clin Porto Alegre, Dept Cardiol, Porto Alegre, RS, Brazil.
[Vetter, Victoria L.] Childrens Hosp Philadelphia, Div Cardiol, Philadelphia, PA 19104 USA.
[Wilson, Mathew G.] Qatar Orthoped & Sports Med Hosp, ASPETAR, Dept Sports Med, Doha, Qatar.
RP Drezner, JA (reprint author), Univ Washington, Dept Family Med, 1959 NE Pacific St,Box 356930, Seattle, WA 98195 USA.
EM jdrezner@uw.edu
OI Borjesson, Mats/0000-0002-8786-0438; Owens, David/0000-0002-7293-9688
NR 67
TC 42
Z9 43
U1 0
U2 14
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0306-3674
J9 BRIT J SPORT MED
JI Br. J. Sports Med.
PD FEB
PY 2013
VL 47
IS 3
BP 153
EP +
DI 10.1136/bjsports-2012-092070
PG 17
WC Sport Sciences
SC Sport Sciences
GA 081VE
UT WOS:000314349700005
PM 23303761
ER
PT J
AU de Mel, G
Sensoy, M
Vasconcelos, W
Norman, TJ
AF de Mel, Geeth
Sensoy, Murat
Vasconcelos, Wamberto
Norman, Timothy J.
TI A hybrid reasoning mechanism for effective sensor selection for tasks
SO ENGINEERING APPLICATIONS OF ARTIFICIAL INTELLIGENCE
LA English
DT Article
DE Logic Programming; Semantic web; Knowledge-based resource selection
ID OWL-DL; RULES; ASSIGNMENT
AB In this paper, we present Ontological Logic Programming (OLP), a novel approach that combines logic programming with ontological reasoning. OLP enables the use of ontological terms (i.e., individuals, classes and properties) directly within logic programmes. The interpretation of these terms is delegated to an ontology reasoner during the interpretation of the programme. Unlike similar approaches, OLP makes use of the full capacity of both ontological reasoning and logic programming. We evaluate the computational properties of OLP in different settings and show that its performance can be significantly improved using caching mechanisms. We then introduce a comprehensive sensor-task selection solution based on OLP and discuss the benefits one can obtain by using OLP. The solution is based on a set of interlinking ontologies that capture the crucial domain knowledge of sensor networks. We then make use of OLP to create and manage complex concepts in the domain as well as to implement effective resource-task assignment algorithms, which compute appropriate resources for tasks such that they sufficiently cover the tasks needs. We compare the advantages of OLP with a knowledge-based set-covering mechanism for resource-task selection. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [de Mel, Geeth; Sensoy, Murat; Vasconcelos, Wamberto; Norman, Timothy J.] Univ Aberdeen, Dept Comp Sci, Aberdeen AB24 3UE, Scotland.
[de Mel, Geeth] USA, Res Lab, Adelphi, MD 20783 USA.
[de Mel, Geeth] IBM Corp, Thomas J Watson Res Ctr, Yorktown Hts, NY 10598 USA.
[Sensoy, Murat] Ozyegin Univ, Dept Comp Sci, Istanbul, Turkey.
RP de Mel, G (reprint author), IBM Corp, Thomas J Watson Res Ctr, Yorktown Hts, NY 10598 USA.
EM grdemel@us.ibm.com; m.sensoy@abdn.ac.uk; w.w.vasconcelos@abdn.ac.uk;
t.j.norman@abdn.ac.uk
FU U.S. Army Research Laboratory [W911NF-06-3-0001]; U.K. Ministry of
Defence [W911NF-06-3-0001]
FX This research was sponsored by the U.S. Army Research Laboratory and the
U.K. Ministry of Defence and was accomplished under Agreement Number
W911NF-06-3-0001. The views and conclusions in this document are those
of the author(s) and should not be interpreted as representing the
official policies, either expressed or implied, of the U.S. Army
Research Laboratory, the U.S. Government, the U.K. Ministry of Defence
or the U.K. Government. The U.S. and U.K. Governments are authorized to
reproduce and distribute reprints for Government purposes
notwithstanding any copyright notation hereon.
NR 39
TC 0
Z9 0
U1 1
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0952-1976
J9 ENG APPL ARTIF INTEL
JI Eng. Appl. Artif. Intell.
PD FEB
PY 2013
VL 26
IS 2
BP 873
EP 887
DI 10.1016/j.engappai.2012.12.003
PG 15
WC Automation & Control Systems; Computer Science, Artificial Intelligence;
Engineering, Multidisciplinary; Engineering, Electrical & Electronic
SC Automation & Control Systems; Computer Science; Engineering
GA 086GP
UT WOS:000314672400018
ER
PT J
AU Warr, BJ
Scofield, DE
Spiering, BA
Alvar, BA
AF Warr, Bradley J.
Scofield, Dennis E.
Spiering, Barry A.
Alvar, Brent A.
TI INFLUENCE OF TRAINING FREQUENCY ON FITNESS LEVELS AND PERCEIVED HEALTH
STATUS IN DEPLOYED NATIONAL GUARD SOLDIERS
SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
LA English
DT Article
DE soldiers; deployment; training frequency; perceived health; fitness
ID PHYSICAL-FITNESS; BODY-COMPOSITION
AB Warr BJ, Scofield DE, Spiering BA, and Alvar BA. Influence of training frequency on fitness levels and perceived health status in deployed National Guard Soldiers. J Strength Cond Res 27 (2): 315-322, 2013-While studies have examined changes in body composition, fitness, and other measures pre- and post-deployment, it is more difficult to characterize physical training practices during deployment. The purpose of this study was to evaluate the association between training frequency during deployment and changes in physical performance, body composition, and perceived health. Eighty-eight Soldiers (men, 76 and women, 12) from the National Guard performed 1 repetition maximum (1RM) bench press, 1RM back squat, and (V) over dotO(2)peak testing within 30 days before and 10 days after deployment to Iraq or Afghanistan. Soldiers completed a questionnaire pertaining to aerobic and strength training frequency, as well as perceived changes to health. Soldiers experienced significant (p <= 0.05) improvements in upper (11%) and lower body strength (14%), declines in body fat percent (-16%), but no change in (V) over dotO(2)peak. About 57% of Soldiers reportedly performed aerobic training >= 3 times per week, whereas 67% performed strength training >= 3 times per week. Soldiers performing aerobic training >= 3 times per week responded differently than those who conducted aerobic training <3 times per week in (V) over dotO(2)peak values (2 vs. -8%, p = 0.016). About 42% of Soldiers reported that their health improved, 36% reported no change to their health, and 22% reported that their health had declined. There was a significant association between training frequency and perceived health. About 50-58% of Soldiers who trained >= 3 times per week reported improvements in health during deployment, whereas only 21-24% of Soldiers who trained <3 times per week reported improvements in health for the same period of time. It seems that Soldiers who train >= 3 times per week experience a more advantageous response in terms of fitness levels and perceived health during deployments.
C1 [Warr, Bradley J.; Scofield, Dennis E.; Spiering, Barry A.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA.
[Alvar, Brent A.] Rocky Mt Univ Hlth Profess, Provo, UT USA.
RP Warr, BJ (reprint author), USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA.
EM bradley.warr@us.army.mil
RI SCOFIELD, DENNIS/F-3636-2015
FU Arizona National Guard; American College of Sports Medicine; United
States Army Research Institute of Environmental Medicine
FX The opinions or assertions contained herein are the private views of the
authors and are not to be construed as official or as reflecting the
views of the Army or the Department of Defense. The authors thank the
Arizona National Guard for their support and participation in this
study. The authors have no conflicts of interest related to the contents
of this manuscript. This study was financially supported by a Doctoral
Student Research Grant from the American College of Sports Medicine and
the United States Army Research Institute of Environmental Medicine.
NR 15
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U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1064-8011
J9 J STRENGTH COND RES
JI J. Strength Cond. Res.
PD FEB
PY 2013
VL 27
IS 2
BP 315
EP 322
PG 8
WC Sport Sciences
SC Sport Sciences
GA 086WB
UT WOS:000314718600006
PM 23222077
ER
PT J
AU Manfredi, TG
Monteiro, MA
Lamont, LS
Singh, MF
Foldvari, M
White, S
Cosmas, AC
Urso, ML
AF Manfredi, Thomas G.
Monteiro, Michael A.
Lamont, Linda S.
Singh, Maria F.
Foldvari, Mona
White, Sebrina
Cosmas, Arthur C.
Urso, Maria L.
TI POSTMENOPAUSAL EFFECTS OF RESISTANCE TRAINING ON MUSCLE DAMAGE AND
MITOCHONDRIA
SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
LA English
DT Article
DE aging; exercise training; strength; muscle adaptation
ID SKELETAL-MUSCLE; OXIDATIVE STRESS; ENZYME-ACTIVITY; HEART-FAILURE; FRAIL
ELDERS; OLDER MEN; EXERCISE; WOMEN; STRENGTH; DISEASE
AB Manfredi, TG, Monteiro, MA, Lamont, LS, Singh, MF, Foldvari, M, White, S, Cosmas, AC, and Urso, ML. Postmenopausal effects of resistance training on muscle damage and mitochondria. J Strength Cond Res 27(2): 556-561, 2013-The purpose of this study was to measure the effects of a 12-month progressive resistance training intervention on muscle morphology and strength gains in postmenopausal women. Skeletal muscle biopsies were obtained from the vastus lateralis of 5 independent community-dwelling women (mean age: 75.6 +/- 4.28 years; mean height: 163 +/- 5.34 cm; mean weight: 72 +/- 17.5 kg) before 6 months and 12 months after progressive resistance training. Muscle strength (1 repetition maximum) was measured at the same time points. After 6 months of training, morphological analysis revealed evidence of increased proteolysis and tissue repair, and rudimentary fiber development. The percent of Z-bands with mild Z-band disruption increased from 43.9% at baseline to 66.7% after 6 months of training (p < 0.01). Mitochondrial volume also increased (percent of mitochondria = 0.86% at baseline, 1.19% at 6 months, and 1.04% at 12 months, p < 0.05), and there was a shift to larger sized mitochondria. The training did not result in statistically significant increases in muscle leg strength (p < 0.18). It appears that mild Z-band disruption acts as a precursor for increased protein synthesis and stimulates an increase in mitochondrial mass. Therefore, although a progressive resistance training program in this population did not increase muscle strength, it did demonstrate clinical applications that lend support to the importance of resistance training in older adults.
C1 [Manfredi, Thomas G.; Monteiro, Michael A.; Lamont, Linda S.; White, Sebrina; Cosmas, Arthur C.] Univ Rhode Isl, Energy Metab Lab, Kingston, RI 02881 USA.
[Manfredi, Thomas G.; Monteiro, Michael A.; Lamont, Linda S.; White, Sebrina; Cosmas, Arthur C.] Univ Rhode Isl, Dept Kinesiol, Kingston, RI 02881 USA.
[Singh, Maria F.; Foldvari, Mona] Tufts Univ, Nutr Exercise Physiol & Sarcopenia Lab, Jean Mayer USDA, Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
[Singh, Maria F.] Univ Sydney, Sch Exercise & Sport Sci, Lidcombe, NSW, Australia.
[Cosmas, Arthur C.] Select Med Sports Med & Outpatient Rehabil, Hartford, CT USA.
[Urso, Maria L.] USA, Mil Performance Div, Inst Environm Med USARIEM, Natick, MA 01760 USA.
RP Urso, ML (reprint author), USA, Mil Performance Div, Inst Environm Med USARIEM, Natick, MA 01760 USA.
EM maria.urso@us.army.mil
FU National Institutes of Health, Institute of General Medical Sciences,
Bridges to the Future [R25 GM51780-02]; University of Rhode Island
FX M. Monteiro was supported by a grant from the National Institutes of
Health, Institute of General Medical Sciences, Bridges to the Future
Grant R25 GM51780-02 awarded to the Kinesiology department (L. S.
Lamont), University of Rhode Island. Disclaimer: The opinions or
assertions contained herein are the private views of the author(s) and
are not to be construed as official or as reflecting the views of the
Army or the Department of Defense.
NR 29
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U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1064-8011
J9 J STRENGTH COND RES
JI J. Strength Cond. Res.
PD FEB
PY 2013
VL 27
IS 2
BP 556
EP 561
PG 6
WC Sport Sciences
SC Sport Sciences
GA 086WB
UT WOS:000314718600037
PM 23090317
ER
PT J
AU Goldman, GH
AF Goldman, Geoffrey H.
TI Doppler-based motion compensation algorithm for focusing the signature
of a rotorcraft
SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
LA English
DT Article
ID TRACKING; AIRCRAFT; SENSOR
AB A computationally efficient algorithm was developed and tested to compensate for the effects of motion on the acoustic signature of a rotorcraft. For target signatures with large spectral peaks that vary slowly in amplitude and have near constant frequency, the time-varying Doppler shift can be tracked and then removed from the data. The algorithm can be used to preprocess data for classification, tracking, and nulling algorithms. The algorithm was tested on rotorcraft data. The average instantaneous frequency of the first harmonic of a rotorcraft was tracked with a fixed-lag smoother. Then, state space estimates of the frequency were used to calculate a time warping that removed the effect of a time-varying Doppler shift from the data. The algorithm was evaluated by analyzing the increase in the amplitude of the harmonics in the spectrum of a rotorcraft. The results depended upon the frequency of the harmonics and the processing interval duration. Under good conditions, the results for the fundamental frequency of the target (similar to 11 Hz) almost achieved an estimated upper bound. The results for higher frequency harmonics had larger increases in the amplitude of the peaks, but significantly lower than the estimated upper bounds. [http://dx.doi.org/10.1121/1.4773273]
C1 USA, Res Lab, ATTN RDRL SES P, Adelphi, MD 20783 USA.
RP Goldman, GH (reprint author), USA, Res Lab, ATTN RDRL SES P, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM geoffrey.h.goldman.civ@mail.mil
NR 28
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U1 0
U2 7
PU ACOUSTICAL SOC AMER AMER INST PHYSICS
PI MELVILLE
PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA
SN 0001-4966
J9 J ACOUST SOC AM
JI J. Acoust. Soc. Am.
PD FEB
PY 2013
VL 133
IS 2
BP 688
EP 696
DI 10.1121/1.4773273
PG 9
WC Acoustics; Audiology & Speech-Language Pathology
SC Acoustics; Audiology & Speech-Language Pathology
GA 080TW
UT WOS:000314267200018
PM 23363088
ER
PT J
AU Pollard, KA
Tran, PK
Letowski, TR
AF Pollard, Kimberly A.
Tran, Phuong K.
Letowski, Tomasz R.
TI A free-field method to calibrate bone conduction transducers
SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
LA English
DT Article
ID ACQUISITION TEST CAT; SPEECH-INTELLIGIBILITY; HEARING PROTECTOR;
BACKGROUND-NOISE; VIBRATORS; EAR; EARPHONES; SOUND; TRANSMISSION;
CANCELLATION
AB Bone conduction communication systems employ a variety of transducers with different physical and electroacoustic properties, and these transducers may be worn at various skull locations. Testing these systems thus requires a reliable means of transducer calibration that can be implemented across different devices, skull locations, and settings. Unfortunately, existing calibration standards do not meet these criteria. Audiometric bone conduction standards focus on only one device model and on limited skull locations. Furthermore, while mechanical couplers may be used for calibration, the general human validity of their results is suspect. To address the need for more flexible, human-centered calibration methods, the authors investigated a procedure for bone transducer calibration, analogous to free-field methods for calibrating air conduction headphones. Participants listened to1s third-octave noise bands (125-12 500 Hz) alternating between a bone transducer and a loudspeaker and adjusted the bone transducer to match the perceived loudness of the loudspeaker at each test frequency. Participants tested two transducer models and two skull locations. Intra-and inter-subject reliability was high, and the resulting data differed by transducer, by location, and from the mechanical coupler. The described procedure is flexible to transducer model and skull location, requires only basic equipment, and directly yields perceptual data. [http://dx.doi.org/10.1121/1.4774273]
C1 [Pollard, Kimberly A.; Tran, Phuong K.; Letowski, Tomasz R.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Pollard, KA (reprint author), USA, Res Lab, 520 Mulberry Point Rd, Aberdeen Proving Ground, MD 21005 USA.
EM kpollard@ucla.edu
FU Oak Ridge Associated Universities postdoctoral fellowship
FX The authors would like to thank all our subjects for participating in
this research. We also thank Paula Henry and Ashley Foots of ARL for
advice and for performing hearing tests on our participants, Walter
Piroth of Sensory Devices for advice and assistance during the study,
and Diana Emanuel of Towson University for allowing us to use their
mechanical coupler. This research was conducted under an Oak Ridge
Associated Universities postdoctoral fellowship to KAP.
NR 50
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U1 0
U2 15
PU ACOUSTICAL SOC AMER AMER INST PHYSICS
PI MELVILLE
PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA
SN 0001-4966
J9 J ACOUST SOC AM
JI J. Acoust. Soc. Am.
PD FEB
PY 2013
VL 133
IS 2
BP 858
EP 865
DI 10.1121/1.4774273
PG 8
WC Acoustics; Audiology & Speech-Language Pathology
SC Acoustics; Audiology & Speech-Language Pathology
GA 080TW
UT WOS:000314267200034
PM 23363104
ER
PT J
AU Corona, BT
Ingalls, CP
AF Corona, Benjamin T.
Ingalls, Christopher P.
TI Immediate force loss after eccentric contractions is increased with
l-name administration, a nitric oxide synthase inhibitor
SO MUSCLE & NERVE
LA English
DT Article
DE eccentric contractions; force; L-NAME; muscle injury; nitric oxide
synthase
ID SKELETAL-MUSCLE CELLS; MOUSE SOLEUS MUSCLE; INDUCED INJURY; COUPLING
FAILURE; EDL MUSCLE; EXERCISE; CALCIUM; STRETCH; DAMAGE
AB Introduction Nitric oxide (NO) signaling regulates many biological processes in skeletal muscle, wherein aberrant signaling contributes to myopathic conditions (e.g., Duchenne muscular dystrophy). NO has been shown to play a role in muscle regeneration after injury. However, less is known about its role during injury. In this study we aimed to determine whether NO synthase (NOS) inhibition exacerbates functional deficits immediately after the performance of eccentric contractions. Methods Wild-type mouse extensor digitorum longus (EDL) muscles underwent in vitro functional testing in the presence or absence of a non-specific NOS inhibitor (L-NAME, 10 mM) before and after performance of 10 eccentric contractions. Results After eccentric contractions, Po was reduced by ?25% for muscle in regular physiological solution but by ?50% with the addition of L-NAME (P = 0.009). Conclusions Non-specific blockade of NOS exacerbates functional deficits immediately after eccentric contractions, suggesting that NO signaling protects skeletal muscle from excessive injury in healthy muscle. Muscle Nerve 47: 271-273, 2013
C1 [Corona, Benjamin T.; Ingalls, Christopher P.] Georgia State Univ, Muscle Biol Lab, Dept Kinesiol & Hlth, Atlanta, GA 30303 USA.
RP Corona, BT (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM benjamin.t.corona.ctr@us.army.mil
FU National Institute of Arthritis and Musculoskeletal and Skin Diseases
[AR-41802]
FX Supported by the National Institute of Arthritis and Musculoskeletal and
Skin Diseases Grant AR-41802.
NR 25
TC 1
Z9 3
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0148-639X
J9 MUSCLE NERVE
JI Muscle Nerve
PD FEB
PY 2013
VL 47
IS 2
BP 271
EP 273
DI 10.1002/mus.23655
PG 3
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 078VS
UT WOS:000314128700016
PM 23349083
ER
PT J
AU Streeck, H
D'Souza, MP
Littman, DR
Crotty, S
AF Streeck, Hendrik
D'Souza, M. Patricia
Littman, Dan R.
Crotty, Shane
TI Harnessing CD4(+) T cell responses in HIV vaccine development
SO NATURE MEDICINE
LA English
DT Article
ID SIMIAN IMMUNODEFICIENCY VIRUS; FOLLICULAR HELPER-CELLS; CHRONIC
VIRAL-INFECTION; MEMORY B-CELLS; GERMINAL CENTER FORMATION; LIVED
PLASMA-CELLS; NEUTRALIZING ANTIBODIES; SIV INFECTION; CUTTING EDGE;
POTENT NEUTRALIZATION
AB CD4(+) T cells can perform a panoply of tasks to shape an effective response against a pathogen. Limited attention has been paid to the potential importance of functional CD4(+) T cell responses in the context of the development of next-generation vaccines, including HIV vaccines. Many CD4(+) T cell functions are newly appreciated and only partially understood. A workshop was held as a forum to bring together a small group of experts to exchange ideas on the role of CD4(+) T cells in developing durable functional antibody responses, via follicular helper T cells, as well as on the roles of CD4(+) T cells in other aspects of protective immunity. Here we discuss whether CD4(+) T cell responses may represent a beneficial component of an efficacious HIV vaccine.
C1 [Streeck, Hendrik] Walter Reed Army Inst Res, Henry M Jackson Fdn, US Mil HIV Res Program, Silver Spring, MD USA.
[D'Souza, M. Patricia] US Natl Inst Allergy & Infect Dis, Vaccine Clin Res Branch, Div Aids, Bethesda, MD USA.
[Littman, Dan R.] New York Univ Sch Med, Kimmel Ctr Biol & Med, Skirball Inst, Mol Pathogenesis Program, New York, NY USA.
[Littman, Dan R.] New York Univ Sch Med, Howard Hughes Med Inst, New York, NY USA.
[Crotty, Shane] La Jolla Inst Allergy & Immunol, Div Vaccine Discovery, La Jolla, CA USA.
[Crotty, Shane] Univ Calif San Diego Sch Med, Dept Med, La Jolla, CA USA.
[Crotty, Shane] Ctr HIV AIDS Vaccine Immunol & Immunogen Discover, La Jolla, CA USA.
RP Streeck, H (reprint author), Walter Reed Army Inst Res, Henry M Jackson Fdn, US Mil HIV Res Program, Silver Spring, MD USA.
EM hstreeck@hivresearch.org; shane@liai.org
FU Division of AIDS of the National Institute of Allergy and Infectious
Diseases of the US National Institutes of Health (NIH); Ragon Institute;
Center for HIV/AIDS Immunology and Immunogen Discovery; NIH
[U19AI090970, P01AI096187]; Henry M. Jackson Foundation for the
Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; US Department
of Defense; [R01AI094602-01]; [R01 AI091450-01]
FX The organizers thank all of the workshop speakers and participants. The
speakers were R. Amara, D. Brooks, M. Cancro, S.C., A. Iwasaki, J.
Kolls, R. Koup, D.R.L., J. Mascola, H.S., J. Wherry and E. Zuniga. This
work was supported by the Division of AIDS of the National Institute of
Allergy and Infectious Diseases of the US National Institutes of Health
(NIH) and the Ragon Institute. S.C. was supported by the Center for
HIV/AIDS Immunology and Immunogen Discovery and NIH U19AI090970 and NIH
P01AI096187. H.S. is supported by R01AI094602-01, R01 AI091450-01 and by
a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson
Foundation for the Advancement of Military Medicine, Inc., and the US
Department of Defense.
NR 99
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U1 1
U2 29
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1078-8956
J9 NAT MED
JI Nat. Med.
PD FEB
PY 2013
VL 19
IS 2
BP 143
EP 149
DI 10.1038/nm.3054
PG 7
WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research &
Experimental
SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental
Medicine
GA 086HY
UT WOS:000314675900022
PM 23389614
ER
PT J
AU Stone, MC
Chen, L
Mckay, SK
Goreham, J
Acharya, K
Fischenich, C
Stone, AB
AF Stone, Mark C.
Chen, Li
Mckay, S. Kyle
Goreham, John
Acharya, Kumud
Fischenich, Craig
Stone, Asako B.
TI BENDING OF SUBMERGED WOODY RIPARIAN VEGETATION AS A FUNCTION OF
HYDRAULIC FLOW CONDITIONS
SO RIVER RESEARCH AND APPLICATIONS
LA English
DT Article
DE riparian vegetation; hydraulic roughness; flood hydraulics; stream
restoration; arid hydrology
ID WIND-TUNNEL MEASUREMENTS; FLEXIBLE VEGETATION; DRAG RELATIONSHIPS;
CONIFEROUS TREES; CHANNEL LININGS; RESISTANCE; STREAMS; GRASS
AB Woody riparian vegetation provides numerous ecological benefits such as stabilizing streambanks, storing and cycling nutrients, shading streams and providing habitat for wildlife. However, vegetation also increases hydraulic roughness and reduces the effective flow area, resulting in an increased water surface elevation for a given streamflow. Balancing the desire to preserve woody vegetation in stream corridors with the need to manage flood risks requires accurate techniques for predicting the influence of vegetation on stream hydraulics. However, this is a challenging problem because woody vegetation responds to the flow field itself by bending and streamlining in response to hydraulic forces. The goal of this study was to predict the bending behaviour of woody riparian vegetation as a function of hydraulic flow conditions. Field tests were performed to elucidate tree biomechanical properties for select riparian taxa of the southwestern USA. Biomechanical results served as input parameters for a numerical algorithm designed to predict tree bending for water velocities likely to be encountered during flood events. Bending simulations revealed appreciable variability in bent tree heights. Variability was likely a manifestation of the extensive variance in plant characteristics and properties inherent in biological specimens. However, no trees were expected to bend to a height lower than approximately 42% of their original height, even in water moving at 2.5m center dot s-1. The results of this work provide an important first step in an effort to predict a dynamic hydraulic roughness for vegetated channels and floodplains under flood conditions. Copyright (c) 2011 John Wiley & Sons, Ltd.
C1 [Stone, Mark C.] Univ New Mexico, Dept Civil Engn, Albuquerque, NM 87131 USA.
[Chen, Li; Acharya, Kumud] Desert Res Inst, Div Hydrol Sci, Las Vegas, NV USA.
[Mckay, S. Kyle] USA, Corps Engineers, Engn Res & Dev Ctr, Athens, GA USA.
[Goreham, John] Matson & Associates, State Coll, PA USA.
[Fischenich, Craig] USA, Corps Engineers, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Stone, Asako B.] Cent New Mexico Community Coll, Albuquerque, NM USA.
RP Stone, MC (reprint author), Univ New Mexico, Dept Civil Engn, Albuquerque, NM 87131 USA.
EM stone@unm.edu
RI Chen, Li/E-3771-2013
OI Chen, Li/0000-0001-9131-1688
NR 36
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Z9 11
U1 1
U2 44
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1535-1459
J9 RIVER RES APPL
JI River Res. Appl.
PD FEB
PY 2013
VL 29
IS 2
BP 195
EP 205
DI 10.1002/rra.1592
PG 11
WC Environmental Sciences; Water Resources
SC Environmental Sciences & Ecology; Water Resources
GA 086UI
UT WOS:000314712700006
ER
PT J
AU Tretyakova, I
Lukashevich, IS
Glass, P
Wang, EY
Weaver, S
Pushko, P
AF Tretyakova, Irina
Lukashevich, Igor S.
Glass, Pamela
Wang, Eryu
Weaver, Scott
Pushko, Peter
TI Novel vaccine against Venezuelan equine encephalitis combines advantages
of DNA immunization and a live attenuated vaccine
SO VACCINE
LA English
DT Article
DE DNA vaccine; Live attenuated virus; Infectious DNA; Venezuelan equine
encephalitis; VEE; TC-83
ID CULEX MELANOCONION TAENIOPUS; E2 ENVELOPE GLYCOPROTEIN; VIRUS SUBTYPE
IAB; NEUTRALIZING ANTIBODIES; ENCEPHALOMYELITIS VIRUS; AEROSOL
CHALLENGE; NONHUMAN-PRIMATES; VECTOR COMPETENCE; IMMUNOGENICITY;
EFFICACY
AB DNA vaccines combine remarkable genetic and chemical stability with proven safety and efficacy in animal models, while remaining less immunogenic in humans. In contrast, live-attenuated vaccines have the advantage of inducing rapid, robust, long-term immunity after a single-dose vaccination. Here we describe novel iDNA vaccine technology that is based on an infectious DNA platform and combines advantages of DNA and live attenuated vaccines. We applied this technology for vaccination against infection with Venezuelan equine encephalitis virus (VEEV), an alphavirus from the Togaviridae family. The iDNA vaccine is based on transcription of the full-length genomic RNA of the TC-83 live-attenuated virus from plasmid DNA in vivo. The in vivo-generated viral RNA initiates limited replication of the vaccine virus, which in turn leads to efficient immunization. This technology allows the plasmid DNA to launch a live-attenuated vaccine in vitro or in vivo. Less than 10 ng of pTC83 iDNA encoding the full-length genomic RNA of the TC-83 vaccine strain initiated replication of the vaccine virus in vitro. In order to evaluate this approach in vivo, BALB/c mice were vaccinated with a single dose of pTC83 iDNA. After vaccination, all mice seroconverted with no adverse reactions. Four weeks after immunization, animals were challenged with the lethal epidemic strain of VEEV. All iDNA-vaccinated mice were protected from fatal disease, while all unvaccinated controls succumbed to infection and died. To our knowledge, this is the first example of launching a clinical live-attenuated vaccine from recombinant plasmid DNA in vivo. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Tretyakova, Irina; Pushko, Peter] Medigen Inc, Frederick, MD 21704 USA.
[Lukashevich, Igor S.] Univ Louisville, Louisville, KY 40202 USA.
[Glass, Pamela] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
[Wang, Eryu; Weaver, Scott] Univ Texas Med Branch, Inst Human Infect & Immun, Sealy Ctr Vaccine Dev, GNL, Galveston, TX 77555 USA.
[Wang, Eryu; Weaver, Scott] Univ Texas Med Branch, Dept Pathol, GNL, Galveston, TX 77555 USA.
RP Pushko, P (reprint author), Medigen Inc, 4539 Metropolitan Court, Frederick, MD 21704 USA.
EM ppushko@medigen-usa.com
FU National Institute of Allergy and Infectious Diseases of the National
Institutes of Health [R43AI094863]
FX Authors thank Michael Parker, Elena Klyushnenkova, Marco Goicochea, Ruth
Florese, Rachmat Hidajat, Brian Nickols, Jason Hearn, and Noble Life
Sciences Inc. for their contributions to this study. The authors declare
that they have no competing financial interests. Research reported in
this publication was supported by the National Institute of Allergy and
Infectious Diseases of the National Institutes of Health under Award
Number R43AI094863. The content is solely the responsibility of the
authors and does not necessarily represent the official views of the
funding agency.
NR 52
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U1 1
U2 21
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
J9 VACCINE
JI Vaccine
PD FEB
PY 2013
VL 31
IS 7
BP 1019
EP 1025
DI 10.1016/j.vaccine.2012.12.050
PG 7
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 083TA
UT WOS:000314486900003
PM 23287629
ER
PT J
AU Kaldy, JE
Shafer, DJ
AF Kaldy, James E.
Shafer, Deborah J.
TI Effects of salinity on survival of the exotic seagrass Zostera japonica
subjected to extreme high temperature stress
SO BOTANICA MARINA
LA English
DT Article
DE mortality; non-indigenous seagrass; thermal threshold; Zostera japonica
ID CLIMATE-CHANGE; INTRODUCED SEAGRASS; HALOPHILA-OVALIS; NORTH-AMERICA;
BAY; USA; ECOSYSTEMS; ESTUARY; LIGHT; WASHINGTON
AB Zostera japonica is a non-indigenous seagrass that is expanding along the Pacific Coast of North America. The ecophysiology of this seagrass is poorly studied and management of the species is fragmented. This split-plot mesocosm experiment was designed to evaluate the response of Z. japonica to chronic, extreme temperature and salinity stress to facilitate development of models to predict potential Z. japonica colonization. We collected Z. japonica plants from Padilla Bay, Washington and Yaquina Bay and Coos Bay, Oregon and exposed them to a constant water temperature of 15 degrees C or 35 degrees C at three different salinities (5, 20 and 35). After 7 days exposure, shoot survival ranged between 6% and 42%; after 9 days exposure, only a few plants from the Yaquina Bay population survived. At a ambient temperature (15 degrees C), no differences were detected among the three salinity treatments. However, at a temperature of 35 degrees C, the survival of plants grown at a salinity of 5 was significantly lower than at higher salinities (20 and 35). Although the effect of population was weak, the northern population appeared to be more susceptible to the combined effects of heat stress and low salinity than the southern populations. We suggest that Z. japonica will continue to spread southward along the Pacific coast of North America until it reaches systems that regularly exceed the temperature tolerances of this non-indigenous seagrass.
C1 [Kaldy, James E.] US EPA, Western Ecol Div, Newport, OR 97365 USA.
[Shafer, Deborah J.] USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Kaldy, JE (reprint author), US EPA, Western Ecol Div, 2111 SE Marine Sci Dr, Newport, OR 97365 USA.
EM kaldy.jim@epa.gov
NR 47
TC 5
Z9 5
U1 5
U2 64
PU WALTER DE GRUYTER & CO
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0006-8055
J9 BOT MAR
JI Bot. Marina
PD FEB
PY 2013
VL 56
IS 1
BP 75
EP 82
DI 10.1515/bot-2012-0144
PG 8
WC Plant Sciences; Marine & Freshwater Biology
SC Plant Sciences; Marine & Freshwater Biology
GA 081XY
UT WOS:000314357200008
ER
PT J
AU Zhivov, A
Liesen, RJ
Richter, S
Jank, R
Underwood, DM
Neth, D
Woody, A
Bjork, C
AF Zhivov, Alexander
Liesen, Richard J.
Richter, Stephan
Jank, Reinhard
Underwood, David M.
Neth, Dieter
Woody, Alfred
Bjork, Curt
TI Energy performance optimization for Army installations
SO BUILDING SERVICES ENGINEERING RESEARCH & TECHNOLOGY
LA English
DT Article
DE Energy performance; energy optimization; army installation; building
cluster; renewable energy; building renovation
AB Buildings contribute to a large fraction of energy usage worldwide. In the United States alone, buildings consume about 40% of total energy expenditure, including 71% of electricity and 54% of natural gas.(1) The Army alone spends more than US $1 billion for building-related energy expenses. The 2005 Energy Policy Act(2) requires that Federal facilities be built to achieve at least a 30% energy savings over the 2004 International Energy Code or ASHRAE Standard 90.1-2004, as appropriate, and that energy efficient designs must be life-cycle cost effective. According to the Energy Independence and Security Act (EISA 2007),(3) new buildings and buildings undergoing major renovations shall be designed to reduce consumption of energy generated off-site or on-site using fossil fuels, as compared with such energy consumption by a similar building in fiscal year 2003 (FY03) as measured by Commercial Buildings Energy Consumption Survey (CBECS) or Residential Energy Consumption Survey (RECS) data from the Energy Information Agency, by 55% in 2010, 80% by 2020, and 100% by 2030. Current US research efforts focus on renewable energy sources and single-building energy efficiency, and pay little attention to integration and minimization of energy use in building communities, i.e. Army installations and university campuses. There is no over arching 'power delivery/energy storage/demand' architecture and methodology to accomplish this.
C1 [Zhivov, Alexander; Liesen, Richard J.; Underwood, David M.] USA, Engineer Res & Dev Ctr, Champaign, IL 61824 USA.
RP Zhivov, A (reprint author), USA, Engineer Res & Dev Ctr, Champaign, IL 61824 USA.
EM Alexander.M.Zhivov@usace.army.mil
FU Installation Management Command (IMCOM); US Army Corps of Engineers
FX Funding for this research was provided by the Installation Management
Command (IMCOM) and the US Army Corps of Engineers.
NR 18
TC 0
Z9 0
U1 0
U2 13
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0143-6244
J9 BUILD SERV ENG RES T
JI Build Serv. Eng. Res. Technol.
PD FEB
PY 2013
VL 34
IS 1
SI SI
BP 87
EP 101
DI 10.1177/0143624412462907
PG 15
WC Construction & Building Technology
SC Construction & Building Technology
GA 077ZE
UT WOS:000314067100007
ER
PT J
AU Brocato, RL
Josleyn, MJ
Wahl-Jensen, V
Schmaljohn, CS
Hooper, JW
AF Brocato, R. L.
Josleyn, M. J.
Wahl-Jensen, V.
Schmaljohn, C. S.
Hooper, J. W.
TI Construction and Nonclinical Testing of a Puumala Virus Synthetic M
Gene-Based DNA Vaccine
SO CLINICAL AND VACCINE IMMUNOLOGY
LA English
DT Article
ID NEUTRALIZING ANTIBODY-RESPONSE; HANTAVIRUS PULMONARY SYNDROME; ANDES
VIRUS; HANTAAN-VIRUS; CYNOMOLGUS MACAQUES; HEMORRHAGIC-FEVER; PROTECTS
HAMSTERS; NEPHROPATHIA-EPIDEMICA; NUCLEOCAPSID PROTEINS;
NONHUMAN-PRIMATES
AB Puumala virus (PUUV) is a causative agent of hemorrhagic fever with renal syndrome (HFRS). Although PUUV-associated HFRS does not result in high case-fatality rates, the social and economic impact is considerable. There is no licensed vaccine or specific therapeutic to prevent or treat HFRS. Here we report the synthesis of a codon-optimized, full-lengthMsegment open reading frame and its cloning into a DNA vaccine vector to produce the plasmid pWRG/PUU-M(s2). pWRG/PUU-M(s2) delivered by gene gun produced high-titer neutralizing antibodies in hamsters and nonhuman primates. Vaccination with pWRG/ PUU-M(s2) protected hamsters against infection with PUUV but not against infection by related HFRS-associated hantaviruses. Unexpectedly, vaccination protected hamsters in a lethal disease model of Andes virus (ANDV) in the absence of ANDV cross-neutralizing antibodies. This is the first evidence that an experimental DNA vaccine for HFRS can provide protection in a hantavirus lethal disease model.
C1 [Brocato, R. L.; Josleyn, M. J.; Wahl-Jensen, V.; Hooper, J. W.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA.
[Wahl-Jensen, V.] NIAID, Integrated Res Facil Ft Detrick, Div Clin Res, NIH, Ft Detrick, MD USA.
RP Hooper, JW (reprint author), USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA.
EM Jay.Hooper@amedd.army.mil
OI Hooper, Jay/0000-0002-4475-0415
FU Military Infectious Disease Research Program (MIDRP); NIAID
[HHSN272200200016I]
FX This work was funded by the Military Infectious Disease Research Program
(MIDRP), Program Area T. R. L. B. and V.W.-J. performed this work as
participants in the National Research Council Associate Program. V.W.-J.
also performed part of this work as an employee of Tunnell Consulting,
Inc., a subcontractor to Battelle Memorial Institute under its prime
contract with NIAID, under contract HHSN272200200016I.
NR 45
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Z9 13
U1 1
U2 9
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 1556-6811
EI 1556-679X
J9 CLIN VACCINE IMMUNOL
JI Clin. Vaccine Immunol.
PD FEB
PY 2013
VL 20
IS 2
BP 218
EP 226
DI 10.1128/CVI.00546-12
PG 9
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 079JI
UT WOS:000314166000013
PM 23239797
ER
PT J
AU Porter, CK
Thura, N
Ranallo, RT
Riddle, MS
AF Porter, C. K.
Thura, N.
Ranallo, R. T.
Riddle, M. S.
TI The Shigella human challenge model
SO EPIDEMIOLOGY AND INFECTION
LA English
DT Review
DE Gastrointestinal infections; Shigella; travellers' infection
ID IRRITABLE-BOWEL-SYNDROME; FLEXNERI 2A; CLINICAL-TRIALS; SONNEI VACCINE;
INFECTION; METAANALYSIS; VOLUNTEERS; EFFICACY; IMMUNOGENICITY;
IMMUNIZATION
AB Shigella is an important bacterial cause of infectious diarrhoea globally. The Shigella human challenge model has been used since 1946 for a variety of objectives including understanding disease pathogenesis, human immune responses and allowing for an early assessment of vaccine efficacy. A systematic review of the literature regarding experimental shigellosis in human subjects was conducted. Summative estimates were calculated by strain and dose. While a total of 19 studies evaluating nine strains at doses ranging from 10 to 1 x 10(10) colony-founing units were identified, most studies utilized the S. sonnei strain 53G and the S. flexneri strain 2457T. Inoculum solution and pre-inoculation buffering has varied over time although diarrhoea attack rates do not appear to increase above 75-80%, and dysentery rates remain fairly constant, highlighting the need for additional dose-ranging studies. Expansion of the model to include additional strains from different serotypes will elucidate serotype and strain-specific outcome variability.
C1 [Porter, C. K.] USN, Enter Dis Dept, Infect Dis Directorate, Med Res Ctr, Silver Spring, MD 20910 USA.
[Ranallo, R. T.] Walter Reed Army Inst Res, Dept Live Attenuated Shigella Vaccines, Bacterial Dis Branch, Silver Spring, MD USA.
RP Porter, CK (reprint author), USN, Enter Dis Dept, Infect Dis Directorate, Med Res Ctr, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM chad.porter@med.navy.mil
FU Military Infectious Disease Research Program funding
FX This study was conducted under support of Military Infectious Disease
Research Program funding. The opinions and assertions herein should not
be construed as official or representing the views of the Department of
the Navy, Department of the Army, the Department of Defense, or the U.S.
Government. This is a U.S. Government work. There are no restrictions on
its use.
NR 32
TC 6
Z9 7
U1 1
U2 25
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0950-2688
J9 EPIDEMIOL INFECT
JI Epidemiol. Infect.
PD FEB
PY 2013
VL 141
IS 2
BP 223
EP 232
DI 10.1017/S0950268812001677
PG 10
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 077FN
UT WOS:000314013400001
PM 22906296
ER
PT J
AU Gurram, P
Kwon, H
AF Gurram, Prudhvi
Kwon, Heesung
TI Sparse Kernel-Based Ensemble Learning With Fully Optimized Kernel
Parameters for Hyperspectral Classification Problems
SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
LA English
DT Article
DE Chemical plume detection; ensemble learning; kernel parameter
optimization; sparse kernel learning; support vector machine (SVM)
ID SUPPORT VECTOR MACHINES; PATTERN-RECOGNITION
AB Recently, a kernel-based ensemble learning technique for hyperspectral detection/classification problems has been introduced by the authors, to provide robust classification over hyperspectral data with relatively high level of noise and background clutter. The kernel-based ensemble technique first randomly selects spectral feature subspaces from the input data. Each individual classifier, which is in fact a support vector machine (SVM), then independently conducts its own learning within its corresponding spectral feature subspace and hence constitutes a weak classifier. The decisions from these weak classifiers are equally or adaptively combined to generate the final ensemble decision. However, in such ensemble learning, little attempt has been previously made to jointly optimize the weak classifiers and the aggregating process for combining the subdecisions. The main goal of this paper is to achieve an optimal sparse combination of the subdecisions by jointly optimizing the separating hyperplane obtained by optimally combining the kernel matrices of the SVM classifiers and the corresponding weights of the subdecisions required for the aggregation process. Sparsity is induced by applying an l1 norm constraint on the weighting coefficients. Consequently, the weights of most of the subclassifiers become zero after the optimization, and only a few of the subclassifiers with non-zero weights contribute to the final ensemble decision. Moreover, in this paper, an algorithm to determine the optimal full-diagonal bandwidth parameters of the Gaussian kernels of the individual SVMs is also presented by minimizing the radius-margin bound. The optimized full-diagonal bandwidth Gaussian kernels are used by the sparse SVM ensemble to perform binary classification. The performance of the proposed technique with optimized kernel parameters is compared to that of the one with single-bandwidth parameter obtained using cross-validation by testing them on various data sets. On an average, the proposed sparse kernel-based ensemble learning algorithm with optimized full-diagonal bandwidth parameters shows an improvement of 20% over the existing ensemble learning techniques.
C1 [Gurram, Prudhvi; Kwon, Heesung] USA, Res Lab, Adelphi, MD 20783 USA.
RP Gurram, P (reprint author), USA, Res Lab, Adelphi, MD 20783 USA.
EM pkgurram@gmail.com; heesung.kwon@us.army.mil
NR 33
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U1 1
U2 25
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0196-2892
J9 IEEE T GEOSCI REMOTE
JI IEEE Trans. Geosci. Remote Sensing
PD FEB
PY 2013
VL 51
IS 2
BP 787
EP 802
DI 10.1109/TGRS.2012.2203603
PG 16
WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote
Sensing; Imaging Science & Photographic Technology
SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science
& Photographic Technology
GA 077HW
UT WOS:000314019500007
ER
PT J
AU Wright, L
Crews, L
Hundley, G
AF Wright, L.
Crews, L.
Hundley, G.
TI 4 YO WITH ATAXIA LAURA A. WRIGHT MD, LADONNA CREWS MD, GRACE HUNDLEY MD
SO JOURNAL OF INVESTIGATIVE MEDICINE
LA English
DT Meeting Abstract
CT Southern Regional Meeting of the
American-Federation-for-Medical-Research
CY FEB 21-23, 2013
CL New Orleans, LA
SP Amer Federat Med Res, So Reg
C1 [Wright, L.; Crews, L.] USA, Mobile, AL USA.
[Hundley, G.] Univ S Alabama, Mobile, AL 36688 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1081-5589
J9 J INVEST MED
JI J. Invest. Med.
PD FEB
PY 2013
VL 61
IS 2
MA 25
BP 379
EP 380
PG 2
WC Medicine, General & Internal; Medicine, Research & Experimental
SC General & Internal Medicine; Research & Experimental Medicine
GA 079FO
UT WOS:000314156100039
ER
PT J
AU Wright, L
Richerson, J
AF Wright, L.
Richerson, J.
TI RARE BRAIN TUMOR DISGUISED AS ATAXIA IN A 23 MONTH OLD MALE
SO JOURNAL OF INVESTIGATIVE MEDICINE
LA English
DT Meeting Abstract
CT Southern Regional Meeting of the
American-Federation-for-Medical-Research
CY FEB 21-23, 2013
CL New Orleans, LA
SP Amer Federat Med Res, So Reg
C1 [Wright, L.; Richerson, J.] USA, Mobile, AL USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1081-5589
J9 J INVEST MED
JI J. Invest. Med.
PD FEB
PY 2013
VL 61
IS 2
MA 192
BP 426
EP 427
PG 2
WC Medicine, General & Internal; Medicine, Research & Experimental
SC General & Internal Medicine; Research & Experimental Medicine
GA 079FO
UT WOS:000314156100207
ER
PT J
AU D'Souza, AJM
Mar, KD
Huang, J
Majumdar, S
Ford, BM
Dyas, B
Ulrich, RG
Sullivan, VJ
AF D'Souza, Ajit Joseph M.
Mar, Kevin D.
Huang, Joanne
Majumdar, Sumit
Ford, Brandi M.
Dyas, Beverly
Ulrich, Robert G.
Sullivan, Vincent J.
TI Rapid deamidation of recombinant protective antigen when adsorbed on
aluminum hydroxide gel correlates with reduced potency of vaccine
SO JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE vaccines; deamidation; biotechnology; chemical stability; protein;
formulation
ID IN-VITRO CORRELATE; INHALATIONAL ANTHRAX; ASPARAGINE DEAMIDATION;
MONOCLONAL-ANTIBODIES; RECEPTOR-BINDING; IMMUNITY; STABILITY; ADJUVANT;
DOMAINS; RABBITS
AB Deamidation of the recombinant protective antigen (rPA) correlates with decreased effectiveness of the vaccine in protecting against infection by Bacillus anthracis. We present data demonstrating dramatic deamidation of amino acid positions 713 and 719 of rPA adsorbed onto aluminum hydroxide gel, an adjuvant, relative to rPA stored in solution without adjuvant. Although deamidation did not impact total levels of rPA-specific antibodies in a mouse model, it did correlate with a decrease in toxin-neutralizing antibodies. On the basis of these data, we hypothesize that interactions of rPA with aluminum hydroxide gel are destabilizing and are the direct cause of reduced vaccine efficacy. (C) 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 102:454461, 2013
C1 [D'Souza, Ajit Joseph M.; Mar, Kevin D.; Huang, Joanne; Majumdar, Sumit; Ford, Brandi M.; Sullivan, Vincent J.] BD Technol, Res Triangle Pk, NC 27709 USA.
[Dyas, Beverly; Ulrich, Robert G.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
RP D'Souza, AJM (reprint author), BD Technol, Res Triangle Pk, NC 27709 USA.
EM ajit_dsouza@bd.com
FU US Department of Defense [DAMD 17-03-2-0037]
FX This work was funded in part by a grant from the US Department of
Defense (award number DAMD 17-03-2-0037).
NR 29
TC 10
Z9 10
U1 0
U2 19
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3549
J9 J PHARM SCI-US
JI J. Pharm. Sci.
PD FEB
PY 2013
VL 102
IS 2
BP 454
EP 461
DI 10.1002/jps.23422
PG 8
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology &
Pharmacy
SC Pharmacology & Pharmacy; Chemistry
GA 074CO
UT WOS:000313790100018
PM 23242822
ER
PT J
AU Shkuratov, Y
Kaydash, V
Korokhin, V
Velikodsky, Y
Petrov, D
Zubko, E
Stankevich, D
Videen, G
AF Shkuratov, Y.
Kaydash, V.
Korokhin, V.
Velikodsky, Y.
Petrov, D.
Zubko, E.
Stankevich, D.
Videen, G.
TI Response to the comment by B. Hapke on "A critical assessment of the
Hapke photometric model"
SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
LA English
DT Article
DE Reflectance; Regolith; Photometry
ID BIDIRECTIONAL REFLECTANCE SPECTROSCOPY; ASYMMETRY PARAMETERS; PHASE
FUNCTION; SCATTERING; PARTICLES; SURFACES; LIGHT
AB In this note we address critical comments given by Hapke (in this issue) [1] on our paper "A critical assessment of the Hapke photometric model" (Shkuratov et al., 2012 121) elaborating further on weak points of this model. One of the main problems of the H-model is the too free juggling with formulas, leading, in particular, to violation of energy conservation. The model is filled with ungrounded approximations and unsupported conclusions. Some of the model assumptions are mutually contradictory, e.g., it considers anisotropic single-particle phase functions to describe incoherent multiple scattering and simultaneously uses the isotropic function in order to calculate coherent backscattering. Another well-known problem of the H-model is that some of the model parameters have similar effects on the reflectance, which makes it difficult to retrieve unique parameter values. The model uses empirical parameters and, hence, is empirical. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Shkuratov, Y.; Kaydash, V.; Korokhin, V.; Velikodsky, Y.; Petrov, D.; Zubko, E.; Stankevich, D.] Kharkov VN Karazin Natl Univ, Astron Inst, UA-61022 Kharkov, Ukraine.
[Shkuratov, Y.] Inst Radio Astron NASU, UA-61022 Kharkov, Ukraine.
[Zubko, E.] Univ Helsinki, Dept Phys, FI-00014 Helsinki, Finland.
[Videen, G.] Space Sci Inst, Boulder, CO 80301 USA.
[Videen, G.] USA, Res Lab, Adelphi, MD 20783 USA.
RP Shkuratov, Y (reprint author), Kharkov VN Karazin Natl Univ, Astron Inst, Sumskaya 35, UA-61022 Kharkov, Ukraine.
EM yuriy.shkuratov@gmail.com
OI Korokhin, Viktor/0000-0002-1911-3422; Velikodsky,
Yuri/0000-0002-8219-128X
NR 23
TC 6
Z9 6
U1 0
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4073
J9 J QUANT SPECTROSC RA
JI J. Quant. Spectrosc. Radiat. Transf.
PD FEB
PY 2013
VL 116
BP 191
EP 195
DI 10.1016/j.jqsrt.2012.11.004
PG 5
WC Optics; Spectroscopy
SC Optics; Spectroscopy
GA 082YR
UT WOS:000314430400019
ER
PT J
AU Duncan, DD
Vogler, AJ
Wolcott, MJ
Li, F
Sarovich, DS
Birdsell, DN
Watson, LM
Hall, TA
Sampath, R
Housley, R
Blyn, LB
Hofstadler, SA
Ecker, DJ
Keim, P
Wagner, DM
Eshoo, MW
AF Duncan, D. D.
Vogler, A. J.
Wolcott, M. J.
Li, F.
Sarovich, D. S.
Birdsell, D. N.
Watson, L. M.
Hall, T. A.
Sampath, R.
Housley, R.
Blyn, L. B.
Hofstadler, S. A.
Ecker, D. J.
Keim, P.
Wagner, D. M.
Eshoo, M. W.
TI Identification and typing of Francisella tularensis with a highly
automated genotyping assay
SO LETTERS IN APPLIED MICROBIOLOGY
LA English
DT Article
DE biosurveillance; Francisella; microbial forensics; tularaemia
ID TANDEM REPEAT ANALYSIS; REAL-TIME PCR; UNIVERSAL BIOSENSOR;
MASS-SPECTROMETRY; MULTIPLE-LOCUS; TICKS; ENDOSYMBIONTS; POLYMERASE;
TULAREMIA; SEQUENCE
AB A PCR assay was developed to genotypically characterize Francisella tularensis and F. novicida. An integrated and partially redundant set of markers was selected to provide positive identification of these species, identify subspecies of F. tularensis and genotype 14 variable number tandem repeat (VNTR) markers. Assay performance was evaluated with 117 Francisella samples. Sample DNA was amplified, and the masses of the PCR products were determined with electrospray ionization/time of flight mass spectrometry (ESI-MS). The base compositions of the PCR amplicons were derived from these high-accuracy mass measurements and contrasted with databased information associated with each of the 25 assay markers. Species and subspecies determinations for all samples were fully concordant with results from established typing methods, and VNTR markers provided additional discrimination among samples. Sequence variants were observed with a number of assay markers, but these did not interfere with sample characterization, and served to increase the genetic diversity detected by the assay. Significance and Impact of the Study Molecular characterization of pathogenic subspecies of Francisella tularensis can be obscured by their near neighbours, which can be prevalent in environmental samples. This study describes a multilocus PCR assay for characterizing key species and subspecies of Francisella at multiple levels of resolution, using stable markers defining phylogenetic groups, together with more variable strain-defining markers. Target loci were selected to form an integrated and semi-redundant panel enabling robust identification of samples, including unique samples showing novel assay signatures. Analyses of environmental isolates and a diverse panel of curated samples exemplified the applications of this approach in surveillance and outbreak studies.
C1 [Duncan, D. D.; Li, F.; Hall, T. A.; Sampath, R.; Housley, R.; Blyn, L. B.; Hofstadler, S. A.; Ecker, D. J.; Eshoo, M. W.] Ibis Biosci, Carlsbad, CA 92008 USA.
[Vogler, A. J.; Sarovich, D. S.; Birdsell, D. N.; Watson, L. M.; Keim, P.; Wagner, D. M.] No Arizona Univ, Ctr Microbial Genet & Genom, Flagstaff, AZ 86011 USA.
[Wolcott, M. J.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
RP Duncan, DD (reprint author), Ibis Biosci, 2251 Faraday Ave,Suite 150, Carlsbad, CA 92008 USA.
EM david.duncan@abbott.com
OI Sarovich, Derek/0000-0002-6944-3980
FU Department of Homeland Security [NBCHC070041]; Joint Programme Executive
Office - Chemical and Biological Defense - Critical Reagents Programme
(JPEO-CBD-CRP)
FX The technical assistance of D. Bedwell, W. Dorman, A. Shea, J.
Carpenter, and H. Miner is gratefully acknowledged. This work was funded
by the Department of Homeland Security contract NBCHC070041 and
sponsored in part by the Joint Programme Executive Office - Chemical and
Biological Defense - Critical Reagents Programme (JPEO-CBD-CRP). The
interpretations and conclusions expressed in this paper are the private
views of the authors and are not necessarily endorsed by the U.S. Army,
the Department of Defense, or the Department of Homeland Security.
NR 34
TC 6
Z9 6
U1 0
U2 15
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0266-8254
J9 LETT APPL MICROBIOL
JI Lett. Appl. Microbiol.
PD FEB
PY 2013
VL 56
IS 2
BP 128
EP 134
DI 10.1111/lam.12022
PG 7
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA 072XR
UT WOS:000313707600008
PM 23121644
ER
PT J
AU Henning, PC
Scofield, DE
Rarick, KR
Pierce, JR
Staab, JS
Lieberman, HR
Nindl, BC
AF Henning, Paul C.
Scofield, Dennis E.
Rarick, Kevin R.
Pierce, Joseph R.
Staab, Jeffery S.
Lieberman, Harris R.
Nindl, Bradley C.
TI Effects of acute caloric restriction compared to caloric balance on the
temporal response of the IGF-I system
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Insulin-like growth factor; Physiological status; Sustained Operations;
Isocaloric
ID GROWTH-FACTOR-I; FACTOR-BINDING PROTEIN-1; ACID-LABILE SUBUNIT;
PHYSICAL-ACTIVITY; BODY-COMPOSITION; ENERGY DEFICIT; INSULIN; MEN;
CONSEQUENCES; PROTEOLYSIS
AB Objective. Insulin-like growth factor-I (IGF-I) is a key regulator of metabolism during altered energy states. The IGF-I system components respond to prolonged caloric restriction but it is not clear if this system responds similarly to acute caloric restriction. The purpose of this study was to characterize the IGF-I system response to acute caloric restriction with a secondary purpose of determining if two isocaloric diets with different ratios of carbohydrate to fat alter the IGF-I system under conditions of caloric balance.
Materials/Methods. A double-blind, placebo-controlled crossover design was used in which 27 subjects underwent three, 48-h experimental treatments: 1) caloric restriction 2) carbohydrate and 3) carbohydrate/fat. Blood was sampled periodically (6 time points total) for IGF-I (total and free), IGFBP51-4, insulin and glucose. ANOVAs were used with significance set at P<0.05.
Results. Total IGF-I decreased 7% during CR (P=0.051) and remained stable during CHO and CHO/F. Free IGF-I decreased 43% during CR (P<0.05) and remained stable during CHO and CHO/F. IGFBP-1 increased by 445% during CR (P<0.05) compared to CHO and CHO/F with no changes for IGFBP-2, IGFBP-3 and IGFBP-4. There was no change in glucose or insulin during CR over the course of the study. Insulin and glucose increased (P<0.05) after a meal in both the CHO and CHO/F groups with no difference between these two groups.
Conclusion. Our findings indicate that free IGF-I decreases and IGFBP-1 increases during caloric restriction, but they are not altered with diets differing in carbohydrate and fat content. Changes in free IGF-I and IGFBP-1 are sensitive to caloric restriction, and their measurement may be valuable in monitoring the physiological response to refeeding in those consuming suboptimal calories. Published by Elsevier Inc.
C1 [Henning, Paul C.; Scofield, Dennis E.; Rarick, Kevin R.; Pierce, Joseph R.; Staab, Jeffery S.; Nindl, Bradley C.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA.
[Lieberman, Harris R.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA.
RP Henning, PC (reprint author), USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA.
EM paul.c.henning@us.army.mil
RI SCOFIELD, DENNIS/F-3636-2015
FU U.S. Army Medical Research and Material Command
FX The authors would like to acknowledge Paul Maguire and Holly McClung for
the development and preparation of the hydrocolloid-based gels, the
technical assistance of Irene Potter, as well as the efforts of the
staff and volunteers that made the data collection possible. This work
was supported by the U.S. Army Medical Research and Material Command.
The opinions or assertions contained herein are the private views of the
authors and are not to be construed as official or as reflecting the
views of the Army or the Department of Defense. Any citations of
commercial organizations and trade names in this report do not
constitute an official Department of the Army endorsement of approval of
the products or services of these organizations.
NR 37
TC 5
Z9 5
U1 0
U2 11
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD FEB
PY 2013
VL 62
IS 2
BP 179
EP 187
DI 10.1016/j.metabol.2012.07.004
PG 9
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 083AY
UT WOS:000314436300002
PM 22906764
ER
PT J
AU Pusateri, AE
Weiskopf, RB
Bebarta, V
Butler, F
Cestero, RF
Chaudry, IH
Deal, V
Dorlac, WC
Gerhardt, RT
Given, MB
Hansen, DR
Hoots, WK
Klein, HG
Macdonald, VW
Mattox, KL
Michael, RA
Mogford, J
Montcalm-Smith, EA
Niemeyer, DM
Prusaczyk, WK
Rappold, JF
Rassmussen, T
Rentas, F
Ross, J
Thompson, C
Tucker, LD
AF Pusateri, Anthony E.
Weiskopf, Richard B.
Bebarta, Vikhyat
Butler, Frank
Cestero, Ramon F.
Chaudry, Irshad H.
Deal, Virgil
Dorlac, Warren C.
Gerhardt, Robert T.
Given, Michael B.
Hansen, Dan R.
Hoots, W. Keith
Klein, Harvey G.
Macdonald, Victor W.
Mattox, Kenneth L.
Michael, Rodney A.
Mogford, Jon
Montcalm-Smith, Elizabeth A.
Niemeyer, Debra M.
Prusaczyk, W. Keith
Rappold, Joseph F.
Rassmussen, Todd
Rentas, Francisco
Ross, James
Thompson, Christopher
Tucker, Leo D.
CA US DoD Hemorrhage Resuscitation Re
TI TRANEXAMIC ACID AND TRAUMA: CURRENT STATUS AND KNOWLEDGE GAPS WITH
RECOMMENDED RESEARCH PRIORITIES
SO SHOCK
LA English
DT Review
DE Tranexamic acid; trauma; efficacy; safety; research requirements
ID PLACEBO-CONTROLLED TRIAL; CARDIAC-SURGERY; CARDIOPULMONARY BYPASS;
SEIZURES; APROTININ; HEMORRHAGE; TRANSFUSION; CRASH-2; SAFETY
AB A recent large civilian randomized controlled trial on the use of tranexamic acid (TXA) for trauma reported important survival benefits. Subsequently, successful use of TXA for combat casualties in Afghanistan was also reported. As a result of these promising studies, there has been growing interest in the use of TXA for trauma. Potential adverse effects of TXA have also been reported. A US Department of Defense committee conducted a review and assessment of knowledge gaps and research requirements regarding the use of TXA for the treatment of casualties that have experienced traumatic hemorrhage. We present identified knowledge gaps and associated research priorities. We believe that important knowledge gaps exist and that a targeted, prioritized research effort will contribute to the refinement of practice guidelines over time.
C1 [Pusateri, Anthony E.] USA, Med Res & Mat Command, Ft Detrick, MD 21702 USA.
[Weiskopf, Richard B.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
[Butler, Frank] Def Hlth Board, Comm Tact Combat Casualty Care, Pensacola, FL USA.
[Cestero, Ramon F.; Ross, James] USN, Med Res Unit, Ft Sam Houston, TX USA.
[Chaudry, Irshad H.] Univ Alabama Birmingham, Birmingham, AL USA.
[Deal, Virgil] US Special Operat Command, Macdill AFB, FL USA.
[Dorlac, Warren C.] Univ Cincinnati, Ctr Sustainment Trauma & Readiness Skills, Cincinnati, OH USA.
[Gerhardt, Robert T.; Rassmussen, Todd] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Given, Michael B.] Off Naval Res, Arlington, VA 22217 USA.
[Hoots, W. Keith] NHLBI, Bethesda, MD 20892 USA.
[Klein, Harvey G.] NIH, Ctr Clin, Bethesda, MD 20892 USA.
[Macdonald, Victor W.; Michael, Rodney A.] US Army Med Mat Dev Act, Ft Detrick, MD USA.
[Mattox, Kenneth L.] Baylor Coll Med, Houston, TX 77030 USA.
[Mogford, Jon] Def Adv Res Projects Agcy, Arlington, VA USA.
[Montcalm-Smith, Elizabeth A.] USN, Med Res Ctr, Silver Spring, MD USA.
[Prusaczyk, W. Keith] USN, Med Res & Dev Ctr, Frederick, MD USA.
[Rappold, Joseph F.] USN, Med Ctr, San Diego, CA 92152 USA.
[Rentas, Francisco] US Armed Serv Blood Program Off, Falls Church, VA USA.
[Thompson, Christopher] USN, Undersea Med Inst, Groton, CT USA.
[Tucker, Leo D.] USA, Med Ctr & Sch, Ft Sam Houston, TX USA.
RP Pusateri, AE (reprint author), USA, DoD Hemorrhage & Resuscitat Res & Dev Program, Combat Casualty Care Res Program, Med Res & Mat Command, Bldg 722, Ft Detrick, MD 21702 USA.
EM anthony.pusateri@amedd.army.mil
RI bebarta, vikhyat/K-3476-2015
NR 34
TC 39
Z9 39
U1 0
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1073-2322
J9 SHOCK
JI Shock
PD FEB
PY 2013
VL 39
IS 2
BP 121
EP 126
DI 10.1097/SHK.0b013e318280409a
PG 6
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA 080ZF
UT WOS:000314282900002
PM 23222525
ER
PT J
AU Jaligama, S
Kale, VM
Wilbanks, MS
Perkins, EJ
Meyer, SA
AF Jaligama, Sridhar
Kale, Vijay M.
Wilbanks, Mitchell S.
Perkins, Edward J.
Meyer, Sharon A.
TI Delayed myelosuppression with acute exposure to
hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and environmental
degradation product hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX)
in rats
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Munitions; Hematotoxicity; Hematopoiesis; Bone marrow
ID HEMATOPOIETIC STEM-CELLS; BONE-MARROW; CYCLOTRIMETHYLENETRINITRAMINE
RDX; HEMOLYTIC-ANEMIA; SEIZURE ACTIVITY; COMPOSITION C-4;
FLOW-CYTOMETRY; CFU-GM; BENZENE; MICE
AB Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), a widely used munitions compound, and hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX), its N-nitroso product of anaerobic microbial nitroreduction, are contaminants of military sites. Previous studies have shown MNX to be the most acutely toxic among the nitroreduced degradation products of RDX and to cause mild anemia at high dose. The present study compares hematotoxicity with acute oral exposure to MNX with parent RDX. Both RDX and MNX caused a modest decrease in blood hemoglobin and similar to 50% loss of granulocytes (NOAELs = 47 mg/kg) in female Sprague-Dawley rats observed 14 days post-exposure. We explored the possibility that blood cell loss observed after 14 days was delayed in onset because of toxicity to bone marrow (BM) progenitors. RDX and MNX decreased granulocyte/macrophage-colony forming cells (GM-CFCs) at 14, but not 7, days (NOAELs = 24 mg/kg). The earliest observed time at which MNX decreased GM-CFCs was 10 days post-exposure. RDX and MNX likewise decreased BM burst-forming units-erythroid (BFU-Es) at 14, but not 7, days. Granulocyte-erythrocyte-monocyte-megakaryocyte (GEMM)-CFCs were unaffected by RDX and MNX at 7 days suggesting precursor depletion did not account for GM-CFC and BFU-E loss. MNX added to the culture media was without effect on GM-CFC formation indicating no direct inhibition. Flow cytometry showed no differential loss of BM multilineage progenitors (Thy1.1(+)) or erythroid (CD71(+)) precursors with MNX suggesting myeloid and erythroid lineages were comparably affected. Collectively, these data indicate that acute exposure to both RDX and MNX caused delayed suppression of myelo- and erythropoiesis with subsequent decrease of peripheral granulocytes and erythrocytes. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Jaligama, Sridhar; Kale, Vijay M.; Wilbanks, Mitchell S.; Meyer, Sharon A.] Univ Louisiana Monroe, Dept Toxicol, Coll Pharm, Monroe, LA 71201 USA.
[Perkins, Edward J.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Meyer, SA (reprint author), Univ Louisiana Monroe, Dept Toxicol, Coll Pharm, 1800 Bienville Dr, Monroe, LA 71201 USA.
EM meyer@ulm.edu
RI Jaligama, Sridhar/D-5533-2015
OI Jaligama, Sridhar/0000-0001-6374-3336
FU US Depatment of Defense [W81XWH-05-10537, W912HZ-05-P-0145]
FX This study was supported by US Depatment of Defense, grant no.
W81XWH-05-10537 and contract no. W912HZ-05-P-0145.
NR 61
TC 0
Z9 0
U1 0
U2 10
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD FEB 1
PY 2013
VL 266
IS 3
BP 443
EP 451
DI 10.1016/j.taap.2012.11.022
PG 9
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA 081NN
UT WOS:000314329000013
PM 23219714
ER
PT J
AU Payne, OJ
Graham, SJ
Dalton, CH
Spencer, PM
Mansson, R
Jenner, J
Azeke, J
Braue, E
AF Payne, O. J.
Graham, S. J.
Dalton, C. H.
Spencer, P. M.
Mansson, R.
Jenner, J.
Azeke, J.
Braue, E.
TI The effects of sulfur mustard exposure and freezing on transdermal
penetration of tritiated water through ex vivo pig skin
SO TOXICOLOGY IN VITRO
LA English
DT Article
DE Sulfur mustard; Freezing; Pig skin; Permeation
ID VITRO PERCUTANEOUS-ABSORPTION; IN-VITRO; STORAGE-CONDITIONS;
PERMEABILITY; DELIVERY; MODELS; BURNS
AB The percutaneous absorption of tritiated water ((H2O)-H-3) through sulfur mustard (SM) exposed abdominal pig skin was measured using in vitro Franz-type static diffusion cells. The barrier function to water permeation following exposure to liquid SM for 8 min and excision 3 h later did not change significantly. A small, but statistically significant difference (P < 0.05) in steady state penetration (Jss), permeability coefficient (Kp) and lag time (t(L)) of (H2O)-H-3 was observed between fresh skin and skin stored frozen (-20 degrees C) for up to two weeks. Steady-state penetration and Kp values were significantly higher (P < 0.05) in skin stored frozen compared with fresh skin. Fresh naive skin had an average Kp of 1.65 x 10(-3) cm h(-1), whereas frozen naive skin was 2.04 x 10(-3) cm h(-1). Fresh SM exposed skin had a mean Kp of 1.72 x 10(-3) - cm h(-1), whereas frozen SM exposed skin was 2.31 x 10(-3) cm h(-1). Lag times were also shorter (P < 0.05) in skin that had been stored frozen. Frozen, SM-exposed porcine abdominal skin may be used for in vitro penetration studies, but effects of treatment and storage on the barrier layer should be taken into account. (c) 2012 Elsevier Ltd. All rights reserved.
C1 [Payne, O. J.; Graham, S. J.; Dalton, C. H.; Jenner, J.] Def Sci & Technol Lab, Dept Biomed Sci, Salisbury SP4 0JQ, Wilts, England.
[Spencer, P. M.; Mansson, R.] Def Sci & Technol Lab, Dept Detect, Salisbury SP4 0JQ, Wilts, England.
[Azeke, J.; Braue, E.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
RP Payne, OJ (reprint author), Def Sci & Technol Lab, Dept Biomed Sci, Salisbury SP4 0JQ, Wilts, England.
EM opayne@dstl.gov.uk
RI Dalton, Christopher/J-5747-2016
OI Dalton, Christopher/0000-0001-7021-781X
FU US Army Medical Research and Materiel Command [W81XWH-08-C-0070]
FX This work is supported by the US Army Medical Research and Materiel
Command under contract No. W81XWH-08-C-0070. The authors would like to
thank the technical assistance kindly provided by Rosi Perrott and
Stephen Rutter.
NR 30
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U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0887-2333
J9 TOXICOL IN VITRO
JI Toxicol. Vitro
PD FEB
PY 2013
VL 27
IS 1
BP 79
EP 83
DI 10.1016/j.tiv.2012.09.015
PG 5
WC Toxicology
SC Toxicology
GA 082DD
UT WOS:000314371600010
PM 23041075
ER
PT J
AU Chandrasekaran, L
Belinskaya, T
Saxena, A
AF Chandrasekaran, Lakshmi
Belinskaya, Tatyana
Saxena, Ashima
TI In vitro characterization of organophosphorus compound hydrolysis by
native and recombinant human prolidase
SO TOXICOLOGY IN VITRO
LA English
DT Article
DE Recombinant; Erythrocytes; Human prolidase; Bioscavenger; OP hydrolysis
ID HUMAN-ERYTHROCYTE PROLIDASE; PYROCOCCUS-FURIOSUS; KIDNEY PROLIDASE;
PURIFICATION; DEFICIENCY; PROTEINS; ENZYME; ACETYLCHOLINESTERASE;
EXPRESSION; PATIENT
AB Human prolidase is a binuclear metalloenzyme, which can potentially function as a catalytic bioscavenger for organophosphorus (OP) nerve agents. Although the biochemical properties of native prolidase purified from human erythrocytes, liver, kidney, and fibroblast cells are well known, it is very poorly characterized with regard to its OP hydrolyzing activity. Also, the high cost of purification of large quantities of native enzyme limits its use as a bioscavenger. Thus, recombinant human prolidase with similar biochemical properties to those of native enzyme would be more suitable as a catalytic bioscavenger. In this study, we established an Escherichia coli expression system, which produced a large amount of tagged human liver prolidase that was purified to over 95% purity from the soluble fraction of cell lysate by affinity chromatography on Streptavidin-agarose resin. The catalytic properties of the recombinant enzyme were compared in vitro with those of highly purified prolidase I isolated from human erythrocytes. The catalytic properties of recombinant prolidase overlap with those of the erythrocyte-derived native enzyme. Both enzymes efficiently hydrolyzed diisopropylfluorophosphate, sarin, soman, tabun and cyclosarin, but were much less efficient at hydrolyzing paraoxon and methyl paraoxon. These results suggest that human prolidase expressed in E. coli is suitable for further development as a catalytic bioscavenger for OP nerve agents. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Chandrasekaran, Lakshmi; Belinskaya, Tatyana; Saxena, Ashima] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA.
RP Saxena, A (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM ashima.saxena@us.army.mil
FU Defense Threat Reduction Agency
FX The authors wish to thank Dr. Robert diTargiani for conducting OP
hydrolysis studies with erythrocyte prolidase, Dr. Neil Jensen and staff
at the Collaborative Research Facility at USAMRICD for help in
conducting studies with OP nerve agents, and Ms. Amy Michels for
assistance in preparation of the manuscript. This research was supported
by funding from the Defense Threat Reduction Agency.
NR 34
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U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0887-2333
J9 TOXICOL IN VITRO
JI Toxicol. Vitro
PD FEB
PY 2013
VL 27
IS 1
BP 499
EP 506
DI 10.1016/j.tiv.2012.05.012
PG 8
WC Toxicology
SC Toxicology
GA 082DD
UT WOS:000314371600060
PM 22677456
ER
PT J
AU Javitt, MC
AF Javitt, Marcia C.
TI Section Editor's Notebook: Technical Advances in Women's Imaging and the
"Digital Native"
SO AMERICAN JOURNAL OF ROENTGENOLOGY
LA English
DT Editorial Material
C1 Uniformed Serv Univ Hlth Sci, Walter Reed Army Med Ctr, Bethesda, MD 20814 USA.
RP Javitt, MC (reprint author), Uniformed Serv Univ Hlth Sci, Walter Reed Army Med Ctr, Bethesda, MD 20814 USA.
EM femscan@aol.com
NR 6
TC 0
Z9 0
U1 0
U2 3
PU AMER ROENTGEN RAY SOC
PI RESTON
PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA
SN 0361-803X
J9 AM J ROENTGENOL
JI Am. J. Roentgenol.
PD FEB
PY 2013
VL 200
IS 2
BP 248
EP 248
DI 10.2214/AJR.12.9261
PG 1
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA 076LG
UT WOS:000313957400021
PM 23345343
ER
PT J
AU Cohen, SP
Galvagno, SM
Plunkett, A
Harris, D
Kurihara, C
Turabi, A
Rehrig, S
Buckenmaier, CC
Chelly, JE
AF Cohen, Steven P.
Galvagno, Samuel M.
Plunkett, Anthony
Harris, Diamond
Kurihara, Connie
Turabi, Ali
Rehrig, Scott
Buckenmaier, Chester C., III
Chelly, Jacques E.
TI A Multicenter, Randomized, Controlled Study Evaluating Preventive
Etanercept on Postoperative Pain After Inguinal Hernia Repair
SO ANESTHESIA AND ANALGESIA
LA English
DT Article
ID TUMOR-NECROSIS-FACTOR; CHRONIC CONSTRICTION INJURY; FACTOR-ALPHA;
RISK-FACTORS; GROIN HERNIA; THORACIC-SURGERY; NEUROPATHIC PAIN; LIMB
AMPUTATION; PHANTOM LIMB; NERVE
AB BACKGROUND: Chronic postsurgical pain (CPSP) affects between 5% and 70% of surgical patients, depending on the surgery. There is no reliable treatment for CPSP which has led to an increased emphasis on prevention. In this study, we sought to determine whether preventive etanercept can decrease the magnitude of postoperative pain and reduce the incidence of CPSP
METHODS: We performed a multicenter, randomized study in 7:7 patients comparing subcutaneous etanercept 50 mg administered 90 minutes before inguinal hernia surgery with saline. Patients, surgeons, anesthesiologists, the injecting physician, nursing staff, and evaluators were blinded. The primary outcome measure was a 24-hour numerical rating scale pain score. Secondary outcome measures were postanesthesia care unit pain scores, 24-hour opioid requirements, time to first analgesic, and pain scores recorded at 1 month, 3 months, 6 months, and 12 months.
RESULTS: Mean 24-hour pain scores were 3.3 (95% confidence interval [CI], 3.2-4.6) in the etanercept and 3.9 (95% Cl, 2.6-4.0) in the control group (P = 0.22). The mean number of analgesic pills used in the first 24 hours was 4.0 (SD, 2.8) in the treatment versus 5.8 (SD, 4.2) in the control group (P = 0.03). At 1 month, 10 patients (29%) in the treatment group reported pain versus 21 (49%) control patients (P = 0,08). The presence of pain at 1 month was significantly associated with pain at 3 months (hazard ratio, 0.74; 99% CI, 0.52-0.97; P = 0.03).
CONCLUSION: Although preventive etanercept was superior to saline in reducing postoperative pain on some measures, the effect sizes were small, transient, and not statistically significant. Different dosing regimens in a larger population should be explored in future studies. (Anesth Analg 2013;116:455-62)
C1 [Cohen, Steven P.; Kurihara, Connie; Turabi, Ali; Buckenmaier, Chester C., III] Walter Reed Natl Mil Med Ctr, Dept Anesthesiol, Baltimore, MD 21205 USA.
[Rehrig, Scott] Walter Reed Natl Mil Med Ctr, Dept Surg, Baltimore, MD 21205 USA.
[Cohen, Steven P.] Johns Hopkins Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD USA.
[Galvagno, Samuel M.] Univ Maryland, Med Ctr, Dept Anesthesiol, Baltimore, MD 21201 USA.
Joint Base Andrews, Andrews AFB, MD USA.
[Plunkett, Anthony] Womack Army Med Ctr, Dept Anesthesiol, Ft Bragg, NC USA.
[Harris, Diamond; Chelly, Jacques E.] Univ Pittsburgh, Sch Med, Dept Anesthesiol, Pittsburgh, PA 15261 USA.
[Buckenmaier, Chester C., III] Def & Vet Ctr Integrat Pain Management, Rockville, MD USA.
RP Cohen, SP (reprint author), Walter Reed Natl Mil Med Ctr, Dept Anesthesiol, 550 N Broadway,Suite 301, Baltimore, MD 21205 USA.
EM scohen40@jhmi.edu
OI rehrig, scott/0000-0002-1287-9708
FU Defense and Veterans Center for Integrative Pain Management, Rockville,
MD
FX Supported in part by a Congressional Grant from the Defense and Veterans
Center for Integrative Pain Management, Rockville, MD.
NR 42
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U1 1
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0003-2999
J9 ANESTH ANALG
JI Anesth. Analg.
PD FEB
PY 2013
VL 116
IS 2
BP 455
EP 462
DI 10.1213/ANE.0b013e318273f71c
PG 8
WC Anesthesiology
SC Anesthesiology
GA 078DJ
UT WOS:000314078300030
PM 23302973
ER
PT J
AU Beltran, MJ
Blair, JA
Huh, J
Kirby, JM
Hsu, JR
AF Beltran, Michael J.
Blair, James A.
Huh, Jeannie
Kirby, Jess M.
Hsu, Joseph R.
CA Skeletal Trauma Res Consortium
TI Articular exposure with the swashbuckler versus a "Mini-swashbuckler"
approach
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Swashbuckler; Distal femur; Minimally invasive; Articular
ID DISTAL FEMORAL FRACTURES; INVASIVE STABILIZATION SYSTEM; INDIRECT
REDUCTION; FEMUR FRACTURES; UNSTABLE FRACTURES; INTERNAL-FIXATION;
EXPERIENCE; PART
AB Objective: To quantify the articular exposure obtained with a Swashbuckler approach to the distal femur and compare this to a "Mini-swashbuckler" approach.
Methods: Forty surgical approaches in 20 fresh-frozen hemipelvis specimens were performed using a Mini-swashbuckler approach followed by a traditional Swashbuckler. Key anatomic landmarks, including the posterior femoral condyles, intercondylar notch, and medial articular margin, were either directly visualised or palpated with a tonsil clamp. Calibrated digital photographs were taken from the surgeon's viewing perspective after each approach. The digital images were then analyzed using a computer software programme, ImageJ (NIH, Bethesda, MD), to calculate the articular surface square area exposed.
Results: The Mini-swashbuckler exposed 87% of the articular surface compared to the Swashbuckler approach (29.48 cm(2) vs 34.03 cm(2), p < 0.0001). Key anatomic landmarks were directly visualised with both exposures in all subjects, including limbs with severe osteoarthritis. Greater exposure with the Mini-swashbuckler correlated with male gender (p < 0.05) and height (p = 0.03) but not weight or BMI.
Conclusions: Although exposure is improved with the use of a Swashbuckler, this difference may not be of clinical importance, since both approaches give either direct visual or tactile access to all critical areas of the distal femur, including the trochlea, entire medial compartment, and both posterior femoral condyles. A less invasive approach allows a smaller surgical dissection without sacrificing the ability to visualise the majority of the articular surface. Published by Elsevier Ltd.
C1 [Beltran, Michael J.; Blair, James A.; Huh, Jeannie] San Antonio Mil Med Ctr, Dept Orthopaed & Rehabil, San Antonio, TX 78234 USA.
[Kirby, Jess M.] USATTC Ryder Trauma Ctr, Dept Orthopaed, Miami, FL 33136 USA.
[Hsu, Joseph R.] USA, Dept Orthopaed & Rehabil, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Beltran, MJ (reprint author), Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA.
EM Michael.beltran@amedd.army.mil; James.blair@amedd.army.mil;
Jeannie.huh@amedd.army.mil; Joseph.Hsu@amedd.army.mil;
Jess.Kirby@amedd.army.mil
NR 24
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U1 0
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
J9 INJURY
JI Injury-Int. J. Care Inj.
PD FEB
PY 2013
VL 44
IS 2
BP 189
EP 193
DI 10.1016/j.injury.2012.10.021
PG 5
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA 072VL
UT WOS:000313701300007
PM 23237603
ER
PT J
AU Eberly, JO
Ringelberg, DB
Indest, KJ
AF Eberly, Jed O.
Ringelberg, David B.
Indest, Karl J.
TI Physiological characterization of lipid accumulation and in vivo ester
formation in Gordonia sp KTR9
SO JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
LA English
DT Article
DE Biodiesel; Triacylglcerides; Fatty acid esters; Gordonia
ID RHODOCOCCUS-ERYTHROPOLIS; BIOFUEL PRODUCTION; ESCHERICHIA-COLI;
TRIACYLGLYCEROL; MICROBES; ALCOHOLS; BACTERIA; BIOLOGY; GROWTH; ADP1
AB Previous work has demonstrated the feasibility of in vivo biodiesel synthesis in Escherichia coli, however, ethyl ester formation was dependent on an external fatty acid feedstock. In contrast to E. coli, actinomycetes may be ideal organisms for direct biodiesel synthesis because of their capacity to synthesize high levels of triacylglcerides (TAGs). In this study, we investigated the physiology and associated TAG accumulation along with the in vivo ability to catalyze ester formation from exogenous short chain alcohol sources in Gordonia sp. KTR9, a strain that possesses a large number of genes dedicated to fatty acid and lipid biosynthesis. Total lipid fatty acids content increased by 75 % and TAG content increased by 50 % under nitrogen starvation conditions in strain KTR9. Strain KTR9 tolerated the exogenous addition of up to 4 % methanol, 4 % ethanol and 2 % propanol in the media. Increasing alcohol concentrations resulted in a decrease in the degree of saturation of recovered fatty acid alcohol esters and a slight increase in the fatty acid chain length. A linear dose dependency in fatty alcohol ester synthesis was observed in the presence of 0.5-2 % methanol and ethanol compared to control KTR9 strains grown in the absence of alcohols. An inspection of the KTR9 genome revealed the presence of several putative wax ester synthase/acyl-coenzyme AaEuroS:aEuroSdiacylglycerol acyltransferase (WS/DGAT) enzymes, encoded by atf gene homologs, that may catalyze the in vivo synthesis of fatty acid esters from short chain alcohols. Collectively, these results indicate that Gordonia sp. KTR9 may be a suitable actinomycete host strain for in vivo biodiesel synthesis.
C1 [Eberly, Jed O.; Indest, Karl J.] USA, Environm Lab, CEERD EP P, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Ringelberg, David B.] USA, Cold Reg Res & Engn Lab, Engn Res & Dev Ctr, Hanover, NH 03755 USA.
RP Indest, KJ (reprint author), USA, Environm Lab, CEERD EP P, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM Karl.J.Indest@usace.army.mil
FU U.S. Army Corps of Engineers Environmental Quality Program [10-50]
FX This research was funded through the U.S. Army Corps of Engineers
Environmental Quality Program (Project 10-50, K. J. Indest). Views,
opinions and/or findings contained herein are those of the authors and
should not be construed as an official Department of the Army position
or decision unless so designated by other official documentation. We
thank Dr. Larry Kirk for technical assistance.
NR 28
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U1 3
U2 22
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1367-5435
J9 J IND MICROBIOL BIOT
JI J. Ind. Microbiol. Biotechnol.
PD FEB
PY 2013
VL 40
IS 2
BP 201
EP 208
DI 10.1007/s10295-012-1218-6
PG 8
WC Biotechnology & Applied Microbiology
SC Biotechnology & Applied Microbiology
GA 074RI
UT WOS:000313830400004
PM 23207981
ER
PT J
AU Chen, SG
Zhang, J
Lumley, L
Cashman, JR
AF Chen, Sigeng
Zhang, Jun
Lumley, Lucille
Cashman, John R.
TI Immunodetection of Serum Albumin Adducts as Biomarkers for
Organophosphorus Exposure
SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
LA English
DT Article
ID INHIBITION ENZYME-IMMUNOASSAY; TRICHOTHECENE MYCOTOXIN T-2; AGENT
FP-BIOTIN; MONOCLONAL-ANTIBODIES; MASS-SPECTROMETRY; SOMAN;
ACETYLCHOLINESTERASE; HYDROLYSIS; BUTYRYLCHOLINESTERASE; CHOLINESTERASES
AB A major challenge in organophosphate (OP) research has been the identification and utilization of reliable biomarkers for the rapid, sensitive, and efficient detection of OP exposure. Although Tyr 411 OP adducts to human serum albumin (HSA) have been suggested to be one of the most robust biomarkers in the detection of OP exposure, the analysis of HSA-OP adduct detection has been limited to techniques using mass spectrometry. Herein, we describe the procurement of two monoclonal antibodies (mAb-HSA-GD and mAb-HSA-VX) that recognized the HSA Tyr 411 adduct of soman (GD) or S-[2-(diisopropylamino)ethyl]-O-ethyl methylphosphonothioate (VX), respectively, but did not recognize nonphosphonylated HSA. We showed that mAb-HSA-GD was able to detect the HSA Tyr 411 OP adduct at a low level (i.e., human blood plasma treated with 180 nM GD) that could not be detected by mass spectrometry. mAb-HSA-GD and mAb-HSA-VX showed an extremely low-level detection of GD adducted to HSA (on the order of picograms). mAb-HSA-GD could also detect serum albumin OP adducts in blood plasma samples from different animals administered GD, including rats, guinea pigs, and monkeys. The ability of the two antibodies to selectively recognize nerve agents adducted to serum albumin suggests that these antibodies could be used to identify biomarkers of OP exposure and provide a new biologic approach to detect OP exposure in animals.
C1 [Chen, Sigeng; Zhang, Jun; Cashman, John R.] Human BioMol Res Inst, San Diego, CA 92121 USA.
[Lumley, Lucille] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
RP Cashman, JR (reprint author), Human BioMol Res Inst, 5310 Eastgate Mall, San Diego, CA 92121 USA.
EM jcashman@hbri.org
RI Chen, Sigeng/G-1678-2014
FU CounterACT Program, National Institutes of Health Office of the
Director; National Institutes of Health National Institute of
Neurological Disorders and Stroke [UO1 NS058038]
FX This work was supported by the CounterACT Program, National Institutes
of Health Office of the Director, and National Institutes of Health
National Institute of Neurological Disorders and Stroke [Grant UO1
NS058038] (J.R.C). Its contents are solely the responsibility of the
authors and do not necessarily represent the official view of the
federal government.
NR 38
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U1 1
U2 26
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0022-3565
J9 J PHARMACOL EXP THER
JI J. Pharmacol. Exp. Ther.
PD FEB
PY 2013
VL 344
IS 2
BP 531
EP 541
DI 10.1124/jpet.112.201368
PG 11
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 073MA
UT WOS:000313745900022
PM 23192655
ER
PT J
AU Burgess, E
AF Burgess, Edwin
TI The Year Without Summer: 1816 and the Volcano That Darkened the World
and Changed History
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA.
RP Burgess, E (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA.
NR 1
TC 0
Z9 0
U1 3
U2 10
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD FEB 1
PY 2013
VL 138
IS 2
BP 74
EP 74
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA 078GD
UT WOS:000314085800136
ER
PT J
AU Busby, RR
Stromberger, ME
Rodriguez, G
Gebhart, DL
Paschke, MW
AF Busby, Ryan R.
Stromberger, Mary E.
Rodriguez, Giselle
Gebhart, Dick L.
Paschke, Mark W.
TI Arbuscular mycorrhizal fungal community differs between a coexisting
native shrub and introduced annual grass
SO MYCORRHIZA
LA English
DT Article
DE Arbuscular mycorrhizal fungi; Artemisia tridentata; Bromus tectorum;
Diversity; Ecological restoration; Plant invasion
ID INVASIVE PLANT SUPPRESSES; BROMUS-TECTORUM-L; ENDOMYCORRHIZAL FUNGI;
TALLGRASS PRAIRIE; EXOTIC GRASSES; SOIL BIOTA; ROOTS; ECOSYSTEMS;
DIVERSITY; FIELD
AB Arbuscular mycorrhizal fungi (AMF) have been implicated in non-native plant invasion success and persistence. However, few studies have identified the AMF species associating directly with plant invaders, or how these associations differ from those of native plant species. Identifying changes to the AMF community due to plant invasion could yield key plant-AMF interactions necessary for the restoration of native plant communities. This research compared AMF associating with coexisting Bromus tectorum, an invasive annual grass, and Artemisia tridentata, the dominant native shrub in western North America. At three sites, soil and root samples from Bromus and Artemisia were collected. Sporulation was induced using trap cultures, and spores were identified using morphological characteristics. DNA was extracted from root and soil subsamples and amplified. Sequences obtained were aligned and analyzed to compare diversity, composition, and phylogenetic distance between hosts and sites. Richness of AMF species associated with Artemisia in cultures was higher than AMF species associated with Bromus. Gamma diversity was similar and beta diversity was higher in AMF associated with Bromus compared to Artemisia. AMF community composition differed between hosts in both cultures and roots. Two AMF species (Archaeospora trappei and Viscospora viscosum) associated more frequently with Artemisia than Bromus across multiple sites. AMF communities in Bromus roots were more phylogenetically dispersed than in Artemisia roots, indicating a greater competition for resources within the invasive grass. Bromus associated with an AMF community that differed from Artemisia in a number of ways, and these changes could restrict native plant establishment.
C1 [Busby, Ryan R.; Stromberger, Mary E.; Paschke, Mark W.] Colorado State Univ, Grad Degree Program Ecol, Ft Collins, CO 80523 USA.
[Busby, Ryan R.; Rodriguez, Giselle; Gebhart, Dick L.] USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA.
[Stromberger, Mary E.] Colorado State Univ, Dept Soil & Crop Sci, Ft Collins, CO 80523 USA.
[Paschke, Mark W.] Colorado State Univ, Dept Forest Rangeland & Watershed Stewardship, Ft Collins, CO 80523 USA.
RP Busby, RR (reprint author), USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, 2902 Newmark Dr, Champaign, IL 61826 USA.
EM Ryan.R.Busby@usace.army.mil
RI Stromberger, Mary/C-3070-2013; Paschke, Mark/E-3799-2013
OI Stromberger, Mary/0000-0002-5862-2932; Paschke, Mark/0000-0002-6345-5905
FU United States Army A896 Direct Funded Research Program
FX The authors thank H. Varani, B. Wolk, L. Bodistow, A. Broz, and the CSU
Sequencing Lab (Colorado State University); J. Morton, R. Bills, S.
Purin, and B. Wheeler (INVAM); J. Bever and W. Kaonongbua (Indiana
University); and N. Raizen (University of Illinois). This research was
funded by the United States Army A896 Direct Funded Research Program.
NR 68
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Z9 13
U1 10
U2 135
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0940-6360
J9 MYCORRHIZA
JI Mycorrhiza
PD FEB
PY 2013
VL 23
IS 2
BP 129
EP 141
DI 10.1007/s00572-012-0455-x
PG 13
WC Mycology
SC Mycology
GA 077VO
UT WOS:000314057300005
PM 22864708
ER
PT J
AU Lee, I
Choi, KK
Noh, Y
Lamb, D
AF Lee, Ikjin
Choi, K. K.
Noh, Yoojeong
Lamb, David
TI Comparison study between probabilistic and possibilistic methods for
problems under a lack of correlated input statistical information
SO STRUCTURAL AND MULTIDISCIPLINARY OPTIMIZATION
LA English
DT Article
DE Identification of joint and marginal CDFs; Confidence level;
Reliability-based design optimization (RBDO); Possibility-based design
optimization (PBDO); Correlated input; Copula
ID RELIABILITY-BASED DESIGN; DIMENSION REDUCTION; OPTIMIZATION
AB In most industrial applications, only limited statistical information is available to describe the input uncertainty model due to expensive experimental testing costs. It would be unreliable to use the estimated input uncertainty model obtained from insufficient data for the design optimization. Furthermore, when input variables are correlated, we would obtain non-optimum design if we assume that they are independent. In this paper, two methods for problems with a lack of input statistical information-possibility-based design optimization (PBDO) and reliability-based design optimization (RBDO) with confidence level on the input model-are compared using mathematical examples and an Abrams M1A1 tank roadarm example. The comparison study shows that PBDO could provide an unreliable optimum design when the number of samples is very small. In addition, PBDO provides an optimum design that is too conservative when the number of samples is relatively large. Furthermore, the obtained PBDO designs do not converge to the optimum design obtained using the true input distribution as the number of samples increases. On the other hand, RBDO with confidence level on the input model provides a conservative and reliable optimum design in a stable manner. The obtained RBDO designs converge to the optimum design obtained using the true input distribution as the number of samples increases.
C1 [Lee, Ikjin] Univ Connecticut, Dept Mech Engn, Storrs, CT 06269 USA.
[Choi, K. K.] Univ Iowa, Dept Mech & Ind Engn, Iowa City, IA 52242 USA.
[Choi, K. K.] Seoul Natl Univ, Dept Naval Architecture & Ocean Engn, Seoul, South Korea.
[Noh, Yoojeong] Keimyung Univ, Dept Mech & Automot Engn, Taegu 704701, South Korea.
[Lamb, David] USA, RDECOM TARDEC, Warren, MI 48397 USA.
RP Choi, KK (reprint author), Univ Iowa, Dept Mech & Ind Engn, Iowa City, IA 52242 USA.
EM ilee@engr.uconn.edu; kkchoi@engineering.uiowa.edu; romana79@kmu.ac.kr;
david.lamb@us.army.mil
RI Lee, IkJin/I-4722-2013; Choi, Kyung/B-1512-2008; Noh,
Yoojeong/E-9833-2015
OI Choi, Kyung/0000-0003-2384-6220;
FU Automotive Research Center; U.S. Army Tank Automotive Research,
Development and Engineering Center (TARDEC); World Class University
Program through the National Research Foundation of Korea (NRF);
Ministry of Education, Science and Technology [R32-2008-000-10161-0]
FX Research is supported by the Automotive Research Center, which is
sponsored by the U.S. Army Tank Automotive Research, Development and
Engineering Center (TARDEC). This research was also partially supported
by the World Class University Program through the National Research
Foundation of Korea (NRF) grant funded by the Ministry of Education,
Science and Technology (Grant Number R32-2008-000-10161-0 in 2009).
NR 44
TC 3
Z9 3
U1 0
U2 20
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1615-147X
J9 STRUCT MULTIDISCIP O
JI Struct. Multidiscip. Optim.
PD FEB
PY 2013
VL 47
IS 2
BP 175
EP 189
DI 10.1007/s00158-012-0833-1
PG 15
WC Computer Science, Interdisciplinary Applications; Engineering,
Multidisciplinary; Mechanics
SC Computer Science; Engineering; Mechanics
GA 074HI
UT WOS:000313803100002
ER
PT J
AU Collins, JL
Peng, XQ
Lee, R
Witriol, A
Pierre, Z
Sciuto, AM
AF Collins, Jennifer L.
Peng, Xinqi
Lee, Robyn
Witriol, Alicia
Pierre, Zdenka
Sciuto, Alfred M.
TI Determination of LCt(50)s in anesthetized rats exposed to aerosolized
nerve agents
SO TOXICOLOGY MECHANISMS AND METHODS
LA English
DT Article
DE Chemical warfare nerve agents; aerosol; inhalation LCt(50)
determination; acetylcholinesterase; anesthetized rodents
ID ACETYLCHOLINESTERASE; STAGEWISE; TOXICITY; SOMAN; DRUGS; GB
AB Nerve agents pose a threat to the respiratory tract with exposure that could result in acute compromised lung performance and death. The determination of toxicity by inhalation is important for the rational development of timely therapeutic countermeasures. This study was designed to deliver aerosolized dilute nerve agents in a dose-response manner to investigate the extent of lethality of nerve agents: soman, sarin, VX and VR. Male rats (240-270 g) were anesthetized intramuscularly with 10 mg/kg xylazine and 90 mg/kg ketamine. Following anesthesia, rats were intubated with a glass endotracheal tube (ET) and placed in a glove box. The ET was connected to a closed circuit nebulizer system (Aeroneb, Aerogen, Inc.) that delivered a particle size of < 2.0 mu m and was in series between the ventilator and the ET. Nerve agents were delivered by a small animal ventilator set for a volume of 2.5 mL x 60-80 breaths/min. VX or VR were nebulized and delivered in concentrations ranging from 6.25-800 mu g/kg over a 10-min exposure time period. Sarin (GB) or soman (GD), 6.5-1250 mu g/kg, were delivered in a similar manner. Lethality by inhalation occurred either during the 10-min exposure period or less than 15 min after the cessation of exposure. Survivors were euthanized at 24 h postexposure. LCt(50) estimates (+/- 95% confidence intervals [CIs]) were obtained from the sequential stage-wise experiments using the probit analysis. Probit analysis revealed that the LD50 for VX was 110.7 mu g/kg (CI: 73.5-166.7), VR 64.2 mu g/kg (CI: 42.1-97.8); soman (GD), 167 mu g/kg (CI: 90-310), and sarin (GB), 154 mu g/kg (CI: 98-242), respectively. Although VR is a structural isomer of VX, the compounds appear to be markedly different in terms of toxicity when delivered by aerosol. These relationships were converted to actual 10 min LCt(50) equivalents: VX = 632.2, VR = 367, GD = 954.3 and GB = 880 mg.min/m(3). Validation of exposure was verified by the determination of blood levels of acetylcholinesterase (AChE) across doses for the agent VR.
C1 [Peng, Xinqi; Lee, Robyn; Witriol, Alicia; Pierre, Zdenka; Sciuto, Alfred M.] USA, Med Toxicol Branch, Analyt Toxicol Div, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
RP Sciuto, AM (reprint author), USA, Med Toxicol Branch, Analyt Toxicol Div, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM alfred.mario.sciuto@us.army.mil
FU Department of Defense and the Defense Threat Reduction Agency
[3.F0007.RC.C.09]
FX This project was supported by the Department of Defense and the Defense
Threat Reduction Agency. 3.F0007.RC.C.09. The authors report no
declarations of interest.
NR 27
TC 3
Z9 5
U1 0
U2 23
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1537-6516
J9 TOXICOL MECH METHOD
JI Toxicol. Mech. Methods
PD FEB
PY 2013
VL 23
IS 2
BP 127
EP 133
DI 10.3109/15376516.2012.730560
PG 7
WC Toxicology
SC Toxicology
GA 079DC
UT WOS:000314149400010
PM 22978758
ER
PT J
AU Pinnick, RG
Fernandez, E
Rosen, JM
Hill, SC
Wang, Y
Pan, YL
AF Pinnick, R. G.
Fernandez, E.
Rosen, J. M.
Hill, S. C.
Wang, Y.
Pan, Y. L.
TI Fluorescence spectra and elastic scattering characteristics of
atmospheric aerosol in Las Cruces, New Mexico, USA: Variability of
concentrations and possible constituents and sources of particles in
various spectral clusters
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Atmospheric aerosol particles; Fluorescence spectra; Elastic scattering;
Clustered spectra; Integrated spectra; Time resolved
ID SOUTHWESTERN UNITED-STATES; BLACK CARBON; SPECTROSCOPY; MATTER
AB The UV-excited laser-induced-fluorescence (UV-LIF) spectra of single atmospheric particles and the three-band integrating-nephelometer elastic scattering of atmospheric aerosol were measured during four approximately 24-h periods on May 2007 in Las Cruces, New Mexico, USA. Aerosol scattering measurements in the nephelometer red channel (50-nm band centered at 700-nm) ranged from around 3-10 times the molecular (Rayleigh) scattering background. On average 22.8% of particles with size greater than about 1 gm diameter have fluorescence above a preset fluorescence threshold. A hierarchical cluster analysis indicates that most of the single-particle UV-LIF spectra fall into about 10 categories (spectral clusters) as found previously at other geographic sites (Pinnick et al., 2004; Pan et al., 2007). The clusters include spectra characteristic of various humic/fulvic acids, humic-like-substances (HULIS), chemically aged terpenes, fungal spores, polycyclic aromatic hydrocarbons, bacteria, cellulose/pollens, and mixtures of various organic carbon compounds. By far the most populated cluster category is similar to those of chemically aged terpenes/humic-materials; on average this population comprises about 62% of fluorescent particles. Clusters with spectra similar to that of some HULIS aerosol contain on average 10.0% of particles; those characteristic of some fungal spores (or perhaps mixtures of aromatic organic compounds) 8.4% of particles; bacteria-like spectra 1.6% of particles; and cellulose/pollen-like spectra 0.8% of particles. Measurements of fluorescent particles over relatively short (24 min) periods reveal that the concentrations of particles in the most populated clusters are highly correlated, suggesting that the particles populating them derive from the same region; these particles might be composed of crustal material coated with secondary organic carbon. On the other hand, concentrations of particles having cellulose-like spectra are generally uncorrelated with those in any other cluster. No clear distinction in fluorescent aerosol characteristics can be seen for different air mass trajectories arriving at the sampling site, suggesting that fluorescent aerosol particles are primarily of local origin. Integrations of the single-particle UV-LIF spectra over approximate 24 h time intervals reveal two broad peaks around 350 nm and 450 nm (for 263 nm excitation); the 450 nm peak is somewhat similar to that measured previously for water soluble organic carbon derived from aerosol collections. The 350 nm peak apparently has not been seen before in measurements of aerosol collections and may derive from non-soluble primary biological aerosol particles such as fungal spores. Further measurements are needed to investigate in more detail the generality of these results. Published by Elsevier Ltd.
C1 [Pinnick, R. G.; Hill, S. C.; Wang, Y.; Pan, Y. L.] USA, Res Lab, Adelphi, MD 20783 USA.
[Pinnick, R. G.; Fernandez, E.; Rosen, J. M.] New Mexico State Univ, Dept Phys, Las Cruces, NM 88003 USA.
RP Pan, YL (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM yongle.pan.civ@mail.mil
FU Defense Threat Reduction Agency under the Physical Science and
Technology Basic Research Program; Army Research Laboratory mission
funds
FX This research was supported by the Defense Threat Reduction Agency under
the Physical Science and Technology Basic Research Program and by Army
Research Laboratory mission funds. We thank David L. Bones and Professor
Sergey Nizkorodov for supplying their fluorescence spectral data on
chemically-aged terpenes.
NR 19
TC 15
Z9 15
U1 4
U2 52
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD FEB
PY 2013
VL 65
BP 195
EP 204
DI 10.1016/j.atmosenv.2012.09.020
PG 10
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA 074UV
UT WOS:000313840500021
ER
PT J
AU Baer, LA
Wu, X
Tou, JC
Johnson, E
Wolf, SE
Wade, CE
AF Baer, L. A.
Wu, X.
Tou, J. C.
Johnson, E.
Wolf, S. E.
Wade, C. E.
TI Contributions of severe burn and disuse to bone structure and strength
in rats
SO BONE
LA English
DT Article
DE Hindlimb unloading; Thermal injury; Femur; Mechanical bending;
Micro-computed tomography
ID SKELETAL-MUSCLE; INSULIN-RESISTANCE; GROWTH-HORMONE; BED REST; INJURY;
OSTEOPOROSIS; MARKERS; EXPRESSION; DECREASES; TURNOVER
AB Burn and disuse results in metabolic and bone changes associated with substantial and sustained bone loss. Such loss can lead to an increased fracture incidence and osteopenia. We studied the independent effects of burn and disuse on bone morphology, composition and strength, and microstructure of the bone alterations 14 days after injury. Sprague-Dawley rats were randomized into four groups: Sham/Ambulatory (SA), Burn/Ambulatory (BA), Sham/Hindlimb Unloaded (SH) and Burn/Hindlimb Unloaded (BH). Burn groups received a 40% total body surface area full-thickness scald burn. Disuse by hindlimb unloading was initiated immediately following injury. Bone turnover was determined in plasma and urine. Femur biomechanical parameters were measured by three-point bending tests and bone microarchitecture was determined by micro-computed tomography (uCT). On day 14, a significant reduction in body mass was observed as a result of burn, disuse and a combination of both. In terms of bone health, disuse alone and in combination affected femur weight, length and bone mineral content. Bending failure energy, an index of femur strength, was significantly reduced in all groups and maximum bending stress was lower when burn and disuse were combined. Osteocalcin was reduced in BA compared to the other groups, indicating influence of burn. The reductions observed in femur weight, BMC, biomechanical parameters and indices of bone formation are primarily responses to the combination of burn and disuse. These results offer insight into bone degradation following severe injury and disuse. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Baer, L. A.; Wu, X.; Wolf, S. E.; Wade, C. E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Baer, L. A.; Wade, C. E.] Univ Texas Hlth Sci Ctr Houston, Dept Surg, Houston, TX 77030 USA.
[Baer, L. A.; Wade, C. E.] Ctr Translat Injury Res, Houston, TX 77030 USA.
[Tou, J. C.] W Virginia Univ, Morgantown, WV 26506 USA.
[Johnson, E.] MD Anderson Small Anim Imaging Facil, Houston, TX 77030 USA.
[Wolf, S. E.] Univ Texas SW Med Ctr Dallas, Dept Surg, Dallas, TX 75390 USA.
RP Baer, LA (reprint author), Univ Texas Hlth Sci Ctr Houston, Dept Surg, 6431 Fannin St,MSB 5-214, Houston, TX 77030 USA.
EM lisa.baer@uth.tmc.edu
OI Wolf, Steven/0000-0003-2972-3440
FU National Institutes of Health [1 R01 GM063120-04]; Technologies for
Metabolic Monitoring (TMM)/Julia Weaver Fund; Congressionally Directed
Program; NASA; Juvenile Diabetes Research Foundation And Combat Casualty
Care Division United States Army Medical Research and Materiel Command
FX This research was funded by the National Institutes of Health (1 R01
GM063120-04); the Technologies for Metabolic Monitoring (TMM)/Julia
Weaver Fund, A Congressionally Directed Program Jointly Managed by the
USA MRMC; NIH; NASA and the Juvenile Diabetes Research Foundation And
Combat Casualty Care Division United States Army Medical Research and
Materiel Command. The funding sources had no involvement in the study
design, data collection, analysis, interpretation of the data, writing
this manuscript or the decision to submit this article for publication.
NR 41
TC 5
Z9 6
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 8756-3282
J9 BONE
JI Bone
PD FEB
PY 2013
VL 52
IS 2
BP 644
EP 650
DI 10.1016/j.bone.2012.10.032
PG 7
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 071PW
UT WOS:000313607700015
PM 23142361
ER
PT J
AU Morrison, JJ
McConnell, NJ
Orman, JA
Egan, G
Jansen, JO
AF Morrison, J. J.
McConnell, N. J.
Orman, J. A.
Egan, G.
Jansen, J. O.
TI Rural and urban distribution of trauma incidents in Scotland
SO BRITISH JOURNAL OF SURGERY
LA English
DT Article
ID INJURED PATIENTS; SYSTEM; OUTCOMES; VOLUME; STATE
AB Background: Trauma systems reduce mortality and improve functional outcomes from injury. Regional trauma networks have been established in several European regions to address longstanding deficiencies in trauma care. A perception of the geography and population distribution as challenging has delayed the introduction of a trauma system in Scotland. The characteristics of trauma incidents attended by the Scottish Ambulance Service were analysed, to gain a better understanding of the geospatial characteristics of trauma in Scotland. Methods: Data on trauma incidents collected by the Scottish Ambulance Service between November 2008 and October 2010 were obtained. Incident location was analysed by health board region, rurality and social deprivation. The results are presented as number of patients, average annual incidence rates and relative risks. Results: Of the 141 668 incidents identified, 72.1 per cent occurred in urban regions. The risk of being involved in an incident was similar across the most populous regions, and decreased slightly with increasing rurality. Social deprivation was associated with greater numbers and risk. A total of 53.1 per cent of patients were taken to a large general hospital, and 38.6 per cent to a teaching hospital; the distribution was similar for the subset of incidents involving patients with physiological derangements. Conclusion: The majority of trauma incidents in Scotland occur in urban and deprived areas. A regionalized system of trauma care appears plausible, although the precise configuration of such a system requires further study. Copyright (c) 2012 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
C1 [Morrison, J. J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham B15 2SQ, W Midlands, England.
[McConnell, N. J.; Jansen, J. O.] Aberdeen Royal Infirm, Dept Surg, Aberdeen, Scotland.
[McConnell, N. J.; Jansen, J. O.] Aberdeen Royal Infirm, Dept Intens Care Med, Aberdeen, Scotland.
[Egan, G.] Scottish Ambulance Serv, Edinburgh, Midlothian, Scotland.
[Morrison, J. J.; Orman, J. A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Orman, J. A.] Univ Texas Hlth Sci Ctr San Antonio, Dept Epidemiol & Biostat, San Antonio, TX 78229 USA.
RP Morrison, JJ (reprint author), Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham B15 2SQ, W Midlands, England.
EM jjmorrison@outlook.com
OI Morrison, Jonathan/0000-0001-7462-8456
NR 29
TC 10
Z9 10
U1 1
U2 13
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1323
J9 BRIT J SURG
JI Br. J. Surg.
PD FEB
PY 2013
VL 100
IS 3
BP 351
EP 359
DI 10.1002/bjs.8982
PG 9
WC Surgery
SC Surgery
GA 070SK
UT WOS:000313531100009
PM 23184249
ER
PT J
AU Hammond, RT
AF Hammond, Richard T.
TI Electrodynamics and Radiation Reaction
SO FOUNDATIONS OF PHYSICS
LA English
DT Article
DE Radiation reaction; Self force
ID RUNAWAY SOLUTIONS; FORCE
AB The self force of electrodynamics is derived from a scalar field. The resulting equation of motion is free of all of the problems that plague the Lorentz Abraham Dirac equation. The age-old problem of a particle in a constant field is solved and the solution has intuitive appeal.
C1 [Hammond, Richard T.] Univ N Carolina, Dept Phys, Chapel Hill, NC 27515 USA.
[Hammond, Richard T.] Army Res Off, Res Triangle Pk, NC USA.
RP Hammond, RT (reprint author), Univ N Carolina, Dept Phys, Chapel Hill, NC 27515 USA.
EM rhammond@email.unc.edu
NR 18
TC 6
Z9 6
U1 0
U2 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0015-9018
J9 FOUND PHYS
JI Found. Phys.
PD FEB
PY 2013
VL 43
IS 2
BP 201
EP 209
DI 10.1007/s10701-012-9687-z
PG 9
WC Physics, Multidisciplinary
SC Physics
GA 074HD
UT WOS:000313802600001
ER
PT J
AU Hamilton, JB
Sandelowski, M
Moore, AD
Agarwal, M
Koenig, HG
AF Hamilton, Jill B.
Sandelowski, Margarete
Moore, Angelo D.
Agarwal, Mansi
Koenig, Harold G.
TI "You Need a Song to Bring You Through": The Use of Religious Songs to
Manage Stressful Life Events
SO GERONTOLOGIST
LA English
DT Article
ID QUALITATIVE CONTENT-ANALYSIS; OLDER AFRICAN-AMERICANS; MENTAL-HEALTH;
INTEGRATIVE REMINISCENCE; DEPRESSIVE SYMPTOMS; SPIRITUALITY; THERAPY;
ADULTS; INTERVENTION; PAIN
AB Purpose: To explore in a sample of older African Americans how religious songs were used to cope with stressful life events and to explore the religious beliefs associated with these songs. Design and Methods: Sixty-five African American older adults residing in the Southeastern US participated in a qualitative descriptive study involving criterion sampling, open-ended semi-structured interviews, qualitative content analysis, and descriptive statistics. Results: Religion expressed through song was a coping strategy for participants experiencing stressful life events who described feelings of being comforted, strengthened, able to endure, uplifted, and able to find peace by turning to the types of religious songs described here. Five types of songs were used including those evoking Thanksgiving and Praise, Instructive, Memory of Forefathers, Communication with God, and Life after Death. Implications: Religious songs are an important form of religious expression important to the mental health of older African Americans. The incorporation of religious songs into spiritual care interventions might enhance the cultural relevance of mental health interventions in this population.
C1 [Hamilton, Jill B.; Sandelowski, Margarete; Agarwal, Mansi] Univ N Carolina, Chapel Hill Sch Nursing, Chapel Hill, NC 27599 USA.
[Moore, Angelo D.] USA, Tripler Army Med Ctr, Honolulu, HI USA.
[Koenig, Harold G.] Duke Univ, Med Ctr, Durham, NC USA.
RP Hamilton, JB (reprint author), Univ N Carolina, Chapel Hill Sch Nursing, CB 7460, Chapel Hill, NC 27599 USA.
EM jhamilto@email.unc.edu
RI Koenig, Harold/F-7379-2011
NR 61
TC 12
Z9 12
U1 1
U2 23
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0016-9013
J9 GERONTOLOGIST
JI Gerontologist
PD FEB
PY 2013
VL 53
IS 1
BP 26
EP 38
DI 10.1093/geront/gns064
PG 13
WC Gerontology
SC Geriatrics & Gerontology
GA 071RV
UT WOS:000313612800004
PM 22589023
ER
PT J
AU Cartagena, CM
Schmid, KE
Phillips, KL
Tortella, FC
Dave, JR
AF Cartagena, Casandra M.
Schmid, Kara E.
Phillips, Katie L.
Tortella, Frank C.
Dave, Jitendra R.
TI Changes in Apoptotic Mechanisms Following Penetrating Ballistic-Like
Brain Injury
SO JOURNAL OF MOLECULAR NEUROSCIENCE
LA English
DT Article
DE Traumatic brain injury; Penetrating brain injury; Apoptosis
ID NECROSIS-FACTOR-ALPHA; BCL-2 FAMILY-MEMBER; TRAUMATIC BRAIN; CELL-DEATH;
NERVOUS-SYSTEM; RAT MODEL; NEUROPROTECTION; INFLAMMATION; INHIBITION;
BARRIER
AB We investigated apoptotic pathways in a model of severe traumatic brain injury, penetrating ballistic-like brain injury (PBBI). TUNEL staining identified increasing apoptosis within 24 h. From targeted arrays, 11 genes were identified for temporal mRNA evaluation. In addition, mRNA levels and enzyme activity for caspases 3, 8, and 9 were examined. In the death receptor-mediated apoptosis pathway, the relative quantities (RQs) of mRNA for tnfr1, fas, and tnf were upregulated while trail mRNA was downregulated. In the anti-apoptotic TNF-R2 pathway, tnfr2 and flip were upregulated while xiap was downregulated. These findings indicate that increases in tnf levels following injury are not only pro-apoptotic but may also signal competing anti-apoptotic mechanisms. For the mitochondria-mediated apoptosis pathway, RQs of anti-apoptotic factors bcl2a1d and birc3 were upregulated while both bcl2 and bax were downregulated. RQs for casp 3 and casp 8 increased while casp9 decreased. Enzymatic activity increased for caspases 3, 8, and 9. While multiple mechanisms promoting and inhibiting apoptosis are at play during the first week after a PBBI, the cumulative result remains increased apoptosis. The ability to understand and dissect these events will assist in the development and evaluation of treatments targeting apoptosis following severe brain injury.
C1 [Cartagena, Casandra M.; Schmid, Kara E.; Phillips, Katie L.; Tortella, Frank C.; Dave, Jitendra R.] Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Dept Brain Trauma Neuroprotect & Neurorestorat, Silver Spring, MD 20910 USA.
RP Cartagena, CM (reprint author), Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Dept Brain Trauma Neuroprotect & Neurorestorat, Silver Spring, MD 20910 USA.
EM casandra.cartagena@us.army.mil; kara.schmid@us.army.mil;
katie.phillips@amedd.army.mil; frank.c.tortella@us.army.mil;
jit.dave@amedd.army.mil
RI Dave, Jitendra/A-8940-2011
NR 34
TC 1
Z9 1
U1 0
U2 7
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0895-8696
J9 J MOL NEUROSCI
JI J. Mol. Neurosci.
PD FEB
PY 2013
VL 49
IS 2
BP 301
EP 311
DI 10.1007/s12031-012-9828-z
PG 11
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 070OW
UT WOS:000313519900008
PM 22684621
ER
PT J
AU Alam, SM
Liao, HX
Tomaras, GD
Bonsignori, M
Tsao, CY
Hwang, KK
Chen, HY
Lloyd, KE
Bowman, C
Sutherland, L
Jeffries, TL
Kozink, DM
Stewart, S
Anasti, K
Jaeger, FH
Parks, R
Yates, NL
Overman, RG
Sinangil, F
Berman, PW
Pitisuttithum, P
Kaewkungwal, J
Nitayaphan, S
Karasavva, N
Rerks-Ngarm, S
Kim, JH
Michael, NL
Zolla-Pazner, S
Santra, S
Letvin, NL
Harrison, SC
Haynes, BF
AF Alam, S. Munir
Liao, Hua-Xin
Tomaras, Georgia D.
Bonsignori, Mattia
Tsao, Chun-Yen
Hwang, Kwan-Ki
Chen, Haiyan
Lloyd, Krissey E.
Bowman, Cindy
Sutherland, Laura
Jeffries, Thomas L., Jr.
Kozink, Daniel M.
Stewart, Shelley
Anasti, Kara
Jaeger, Frederick H.
Parks, Robert
Yates, Nicole L.
Overman, R. Glenn
Sinangil, Faruk
Berman, Phillip W.
Pitisuttithum, Punnee
Kaewkungwal, Jaranit
Nitayaphan, Sorachai
Karasavva, Nicos
Rerks-Ngarm, Supachai
Kim, Jerome H.
Michael, Nelson L.
Zolla-Pazner, Susan
Santra, Sampa
Letvin, Norman L.
Harrison, Stephen C.
Haynes, Barton F.
TI Antigenicity and Immunogenicity of RV144 Vaccine AIDSVAX Clade E
Envelope Immunogen Is Enhanced by a gp120 N-Terminal Deletion
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID IMMUNODEFICIENCY-VIRUS TYPE-1; BROADLY NEUTRALIZING ANTIBODIES; HUMAN
MONOCLONAL-ANTIBODIES; PREVENT HIV-1 INFECTION; V1/V2 DOMAIN; BINDING
INTERACTIONS; EFFICACY TRIAL; EPITOPES; GLYCOPROTEINS; MEMBRANE
AB An immune correlates analysis of the RV144 HIV-1 vaccine trial revealed that antibody responses to the gp120 V1/V2 region correlated inversely with infection risk. The RV144 protein immunogens (A244-rp120 and MN-rgp120) were modified by an N-terminal 11-amino-acid deletion (Delta 11) and addition of a herpes simplex virus (HSV) gD protein-derived tag (gD). We investigated the effects of these modifications on gp120 expression, antigenicity, and immunogenicity by comparing unmodified A244 gp120 with both Delta 11 deletion and gD tag and with Delta 11 only. Analysis of A244 gp120, with or without Delta 11 or gD, demonstrated that the Delta 11 deletion, without the addition of gD, was sufficient for enhanced antigenicity to gp120 C1 region, conformational V2, and V1/V2 gp120 conformational epitopes. RV144 vaccinee serum IgGs bound more avidly to A244 gp120 Delta 11 than to the unmodified gp120, and their binding was blocked by C1, V2, and V1/V2 antibodies. Rhesus macaques immunized with the three different forms of A244 gp120 proteins gave similar levels of gp120 antibody titers, although higher antibody titers developed earlier in A244 Delta 11 gp120-immunized animals. Conformational V1/V2 monoclonal antibodies (MAbs) gave significantly higher levels of blocking of plasma IgG from A244 Delta 11 gp120-immunized animals than IgG from animals immunized with unmodified A244 gp120, thus indicating a qualitative difference in the V1/V2 antibodies induced by A244 Delta 11 gp120. These results demonstrate that deletion of N-terminal residues in the RV144 A244 gp120 immunogen improves both envelope antigenicity and immunogenicity.
C1 [Alam, S. Munir; Liao, Hua-Xin; Tomaras, Georgia D.; Bonsignori, Mattia; Tsao, Chun-Yen; Hwang, Kwan-Ki; Chen, Haiyan; Lloyd, Krissey E.; Bowman, Cindy; Sutherland, Laura; Jeffries, Thomas L., Jr.; Kozink, Daniel M.; Stewart, Shelley; Anasti, Kara; Jaeger, Frederick H.; Parks, Robert; Yates, Nicole L.; Overman, R. Glenn; Pitisuttithum, Punnee; Haynes, Barton F.] Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC 27706 USA.
[Sinangil, Faruk] Global Solut Infect Dis, San Francisco, CA USA.
[Berman, Phillip W.] Univ Calif Santa Cruz, Santa Cruz, CA 95064 USA.
[Kaewkungwal, Jaranit] Mahidol Univ, Fac Trop Med, Bangkok, Thailand.
[Nitayaphan, Sorachai; Karasavva, Nicos] Armed Forces Res Inst Med Sci, Dept Retrovirol, Bangkok 10400, Thailand.
[Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand.
[Kim, Jerome H.; Michael, Nelson L.] Walter Reed Army Inst Res, US Mil Res Program, Rockville, MD USA.
[Zolla-Pazner, Susan] Vet Affairs New York Harbor Healthcare Syst, New York, NY USA.
[Zolla-Pazner, Susan] NYU, Sch Med, Dept Pathol, New York, NY USA.
[Santra, Sampa; Letvin, Norman L.] Harvard Univ, Beth Israel Deaconess Med Ctr, Dept Med, Sch Med, Boston, MA 02215 USA.
[Harrison, Stephen C.] Harvard Univ, Sch Med, Boston Childrens Hosp, Boston, MA USA.
[Harrison, Stephen C.] Howard Hughes Med Inst, Chevy Chase, MD USA.
RP Alam, SM (reprint author), Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC 27706 USA.
EM alam0004@mc.duke.edu; hayne002@mc.duke.edu
RI Tomaras, Georgia/J-5041-2016
FU Bill & Melinda Gates Foundation; National Institutes of Allergy and
Infectious Diseases, Division of AIDS, Department of Health and Human
Sciences, through a U01-grant from the NIH, NIAID [AI067854]; NIH, NHLBI
[HL59725]; Department of Veterans Affairs; U.S. Army Medical Research
and Materiel Command [Y1-AI-2642-12]; National Institute of Allergy and
Infectious Diseases; Henry M. Jackson Foundation for the Advancement of
Military Medicine [W81XWH-07-2-0067]; U.S. Department of Defense
[W81XWH-07-2-0067]; Fisher BioServices [FBS50035-15]; NYU [FBS50035-15]
FX This study was supported in part by the Bill & Melinda Gates Foundation
and Collaboration for AIDS Vaccine Discovery (CAVD) and CAVD-VIMC
grants, by the National Institutes of Allergy and Infectious Diseases,
Division of AIDS, Department of Health and Human Sciences, through a
U01-grant from the NIH, NIAID, AI067854 (the Center for HIV/AIDS Vaccine
Immunology), by NIH, NHLBI, HL59725, and by research funds from the
Department of Veterans Affairs. This work was also supported in part by
an Interagency Agreement (Y1-AI-2642-12) between the U.S. Army Medical
Research and Materiel Command and the National Institute of Allergy and
Infectious Diseases, by a cooperative agreement (W81XWH-07-2-0067)
between the Henry M. Jackson Foundation for the Advancement of Military
Medicine and the U.S. Department of Defense, and by a contract between
Fisher BioServices and NYU (FBS50035-15).
NR 45
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U1 1
U2 29
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD FEB
PY 2013
VL 87
IS 3
BP 1554
EP 1568
DI 10.1128/JVI.00718-12
PG 15
WC Virology
SC Virology
GA 071AR
UT WOS:000313558100024
PM 23175357
ER
PT J
AU Pegu, P
Vaccari, M
Gordon, S
Keele, BF
Doster, M
Guan, YJ
Ferrari, G
Pal, R
Ferrari, MG
Whitney, S
Hudacik, L
Billings, E
Rao, M
Montefiori, D
Tomaras, G
Alam, SM
Fenizia, C
Lifson, JD
Stablein, D
Tartaglia, J
Michael, N
Kim, J
Venzon, D
Franchini, G
AF Pegu, Poonam
Vaccari, Monica
Gordon, Shari
Keele, Brandon F.
Doster, Melvin
Guan, Yongjun
Ferrari, Guido
Pal, Ranajit
Ferrari, Maria Grazia
Whitney, Stephen
Hudacik, Lauren
Billings, Erik
Rao, Mangala
Montefiori, David
Tomaras, Georgia
Alam, S. Munir
Fenizia, Claudio
Lifson, Jeffrey D.
Stablein, Donald
Tartaglia, Jim
Michael, Nelson
Kim, Jerome
Venzon, David
Franchini, Genoveffa
TI Antibodies with High Avidity to the gp120 Envelope Protein in Protection
from Simian Immunodeficiency Virus SIVmac251 Acquisition in an
Immunization Regimen That Mimics the RV-144 Thai Trial
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID PREVENT HIV-1 INFECTION; VACCINE EFFICACY TRIAL; RHESUS MACAQUES;
INTEGRIN ALPHA(4)BETA(7); GAG/POL/NEF VACCINE; CHALLENGE EXPOSURE; SIV
CHALLENGE; DOUBLE-BLIND; T-CELLS; B-CELL
AB The recombinant canarypox vector, ALVAC-HIV, together with human immunodeficiency virus (HIV) gp120 envelope glycoprotein, has protected 31.2% of Thai individuals from HIV acquisition in the RV144 HIV vaccine trial. This outcome was unexpected, given the limited ability of the vaccine components to induce CD8(+)T-cell responses or broadly neutralizing antibodies. We vaccinated macaques with an immunization regimen intended to mimic the RV144 trial and exposed them intrarectally to a dose of the simian immunodeficiency virus SIVmac251 that transmits few virus variants, similar to HIV transmission to humans. Vaccination induced anti-envelope antibodies in all vaccinees and CD4(+) and CD8(+)T-cell responses. Three of the 11 macaques vaccinated with ALVAC-SIV/gp120 were protected from SIVmac251 acquisition, but the result was not significant. The remaining vaccinees were infected and progressed to disease. The magnitudes of vaccine-induced SIVmac251-specific T-cell responses and binding antibodies were not significantly different between protected and infected animals. However, sera from protected animals had higher avidity antibodies to gp120, recognized the variable envelope regions V1/V2, and reduced SIVmac251 infectivity in cells that express high levels of alpha(4)beta(7) integrins, suggesting a functional role of antibodies to V2. The current results emphasize the utility of determining the titer of repeated mucosal challenge in the preclinical evaluation of HIV vaccines.
C1 [Pegu, Poonam; Vaccari, Monica; Gordon, Shari; Doster, Melvin; Fenizia, Claudio; Franchini, Genoveffa] NCI, Anim Models & Retroviral Vaccine Sect, NIH, Bethesda, MD 20892 USA.
[Keele, Brandon F.; Lifson, Jeffrey D.] SAIC Frederick Inc, AIDS & Canc Virus Program, Frederick Natl Lab Canc Res, Frederick, MD USA.
[Guan, Yongjun] Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA.
[Guan, Yongjun] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA.
[Ferrari, Guido; Montefiori, David; Tomaras, Georgia; Alam, S. Munir] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA.
[Pal, Ranajit; Ferrari, Maria Grazia; Whitney, Stephen; Hudacik, Lauren] Adv Biosci Labs, Rockville, MD USA.
[Billings, Erik; Rao, Mangala] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Stablein, Donald] EMMES Corp, Rockville, MD USA.
[Tartaglia, Jim] Sanofi Pasteur Inc, Swiftwater, PA USA.
[Venzon, David] NCI, Biostat & Data Management Sect, Bethesda, MD 20892 USA.
RP Franchini, G (reprint author), NCI, Anim Models & Retroviral Vaccine Sect, NIH, Bethesda, MD 20892 USA.
EM franchig@mail.nih.gov
RI Ferrari, Guido/A-6088-2015; Tomaras, Georgia/J-5041-2016
FU NIH; NCI [HHSN2662004000088C]
FX This research was supported by the Intramural Research Program of the
NIH, NCI, and under NCI contract HHSN2662004000088C.
NR 56
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U1 4
U2 15
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD FEB
PY 2013
VL 87
IS 3
BP 1708
EP 1719
DI 10.1128/JVI.02544-12
PG 12
WC Virology
SC Virology
GA 071AR
UT WOS:000313558100037
PM 23175374
ER
PT J
AU Morrison, JJ
Oh, J
DuBose, JJ
O'Reilly, DJ
Russell, RJ
Blackbourne, LH
Midwinter, MJ
Rasmussen, TE
AF Morrison, Jonathan J.
Oh, John
DuBose, Joseph J.
O'Reilly, David J.
Russell, Robert J.
Blackbourne, Lorne H.
Midwinter, Mark J.
Rasmussen, Todd E.
TI En-Route Care Capability From Point of Injury Impacts Mortality After
Severe Wartime Injury
SO ANNALS OF SURGERY
LA English
DT Article
DE casualty evacuation; combat injury; medical evacuation; trauma; wartime
injury
ID EMERGENCY MEDICAL-SERVICES; COMBAT CASUALTY CARE; SURVIVAL; TRAUMA; WAR;
BATTLEFIELD; AFGHANISTAN; DEATH
AB Objective: The objective of this study is to characterize modern point-of-injury (POI) en-route care platforms and to compare mortality among casualties evacuated with conventional military retrieval (CMR) methods to those evacuated with an advanced medical retrieval (AMR) capability.
Background: Following a decade of war in Afghanistan, the impact of en-route care capabilities from the POI on mortality is unknown.
Methods: Casualties evacuated from POI to one level III facility in Afghanistan (July 2008 March 2012) were identified from UK and US trauma registries. Groups comprised those evacuated by a medically qualified provider-led, AMR and those by a medic-led CMR capability. Outcomes were compared per incremental Injury Severity Score (ISS) bins.
Results: Most casualties (n = 1054; 61.2%) were in the low-ISS (1-15) bracket in which there was no difference in en-route care time or mortality between AMR and CMR. Casualties in the mid-ISS bracket (16-50) (n = 583; 33.4%) experienced the same median en-route care time (minutes) on AMR and CMR platforms [78 (58) vs 75 (93); P = 0.542] although those on AMR had shorter time to operation [110 (95) vs 117 (126); P < 0.001]. In this mid-ISS bracket, mortality was lower in the AMR than in the CMR group (12.2% vs 18.2%; P = 0.035). In the high-ISS category (51-75) (n = 75; 4.6%), time to operation was lower in the AMR than the CMR group (66 +/- 77 vs 113 +/- 122; P = 0.013) but there was no difference in mortality.
Conclusions: This study characterizes en-route care capabilities from POI in modern combat. Conventional platforms are effective in most casualties with low injury severity. However, a definable injury severity exists for which evacuation with an AMR capability is associated with improved survival.
C1 [Morrison, Jonathan J.; Blackbourne, Lorne H.; Rasmussen, Todd E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Morrison, Jonathan J.; O'Reilly, David J.; Midwinter, Mark J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England.
[Oh, John] Landstuhl Reg Med Ctr, Landstuhl, Germany.
[DuBose, Joseph J.] R Adams Cowley Shock Trauma Ctr, C STARS Baltimore, Baltimore, MD USA.
[Russell, Robert J.] Royal Ctr Def Med, Acad Dept Mil Emergency Med, Birmingham, W Midlands, England.
[Rasmussen, Todd E.] Sci & Technol Sect, Med Deployment Wing 59, Lackland AFB, TX USA.
[Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA.
RP Rasmussen, TE (reprint author), USA, Inst Surg Res, San Antonio, TX 78234 USA.
EM todd.rasmussen@amedd.army.mil
RI Midwinter, Mark/P-6264-2015;
OI Midwinter, Mark/0000-0003-1836-7137; Morrison,
Jonathan/0000-0001-7462-8456
FU Office of the US Air Force Surgeon General
FX This work was supported by the Office of the US Air Force Surgeon
General and was created in the performance of a contract with the Air
Force Medical Support Agency. The viewpoints expressed in this article
are those of the authors and do not reflect the official position of the
US Department of Defense or the UK Defence Medical Service.
NR 24
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U1 2
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0003-4932
J9 ANN SURG
JI Ann. Surg.
PD FEB
PY 2013
VL 257
IS 2
BP 330
EP 334
DI 10.1097/SLA.0b013e31827eefcf
PG 5
WC Surgery
SC Surgery
GA 068IX
UT WOS:000313361300023
PM 23291661
ER
PT J
AU Ouattara, A
Takala-Harrison, S
Thera, MA
Coulibaly, D
Niangaly, A
Saye, R
Tolo, Y
Dutta, S
Heppner, DG
Soisson, L
Diggs, CL
Vekemans, J
Cohen, J
Blackwelder, WC
Dube, T
Laurens, MB
Doumbo, OK
Plowe, CV
AF Ouattara, Amed
Takala-Harrison, Shannon
Thera, Mahamadou A.
Coulibaly, Drissa
Niangaly, Amadou
Saye, Renion
Tolo, Youssouf
Dutta, Sheetij
Heppner, D. Gray
Soisson, Lorraine
Diggs, Carter L.
Vekemans, Johan
Cohen, Joe
Blackwelder, William C.
Dube, Tina
Laurens, Matthew B.
Doumbo, Ogobara K.
Plowe, Christopher V.
TI Molecular Basis of Allele-Specific Efficacy of a Blood-Stage Malaria
Vaccine: Vaccine Development Implications
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE Malaria; Plasmodium falciparum; apical membrane antigen 1; AMA1; vaccine
trial; allele-specific efficacy; cluster 1 loop
ID APICAL MEMBRANE ANTIGEN-1; PLASMODIUM-FALCIPARUM; ANTIBODY; TRIAL;
RESPONSES; POLYMORPHISMS; PROTECTION; DIVERSITY; SELECTION; RESIDUE
AB The disappointing efficacy of blood-stage malaria vaccines may be explained in part by allele-specific immune responses that are directed against polymorphic epitopes on blood-stage antigens. FMP2.1/AS02(A), a blood-stage candidate vaccine based on apical membrane antigen 1 (AMA1) from the 3D7 strain of Plasmodium falciparum, had allele-specific efficacy against clinical malaria in a phase II trial in Malian children. We assessed the cross-protective efficacy of the malaria vaccine and inferred which polymorphic amino acid positions in AMA1 were the targets of protective allele-specific immune responses. FMP2.1/AS02(A) had the highest efficacy against AMA1 alleles that were identical to the 3D7 vaccine-type allele at 8 highly polymorphic amino acid positions in the cluster 1 loop (c1L) but differed from 3D7 elsewhere in the molecule. Comparison of the incidence of vaccine-type alleles before and after vaccination in the malaria vaccine and control groups and examination of the patterns of allele change at polymorphic positions in consecutive malaria episodes suggest that the highly polymorphic amino acid position 197 in c1L was the most critical determinant of allele-specific efficacy. These results indicate that a multivalent AMA1 vaccine with broad efficacy could include only a limited set of key alleles of this extremely polymorphic antigen.
C1 [Ouattara, Amed; Thera, Mahamadou A.; Coulibaly, Drissa; Niangaly, Amadou; Saye, Renion; Tolo, Youssouf; Doumbo, Ogobara K.] Univ Sci Tech & Technol, Malaria Res & Training Ctr, Bamako, Mali.
[Ouattara, Amed; Takala-Harrison, Shannon; Blackwelder, William C.; Laurens, Matthew B.; Plowe, Christopher V.] Univ Maryland, Sch Med, Howard Hughes Med Inst, Ctr Vaccine Dev, Baltimore, MD 21201 USA.
[Dutta, Sheetij; Heppner, D. Gray] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA.
[Dube, Tina] EMMES, Rockville, MD USA.
[Soisson, Lorraine; Diggs, Carter L.] US Agcy Int Dev, Malaria Vaccine Dev Program, Washington, DC 20523 USA.
[Vekemans, Johan; Cohen, Joe] GlaxoSmithKline Biol, Rixensart, Belgium.
RP Plowe, CV (reprint author), Univ Maryland, Sch Med, Howard Hughes Med Inst, Ctr Vaccine Dev, 685 W Baltimore St,HSF1-480, Baltimore, MD 21201 USA.
EM cplowe@medicine.umaryland.edu
RI Laurens, Matthew/E-7293-2013
OI Laurens, Matthew/0000-0003-3874-581X
FU National Institute of Allergy and Infectious Diseases [N01AI85346,
U19AI065683]; Fogarty International Center of the National Institutes of
Health [D43TW001589]; US Department of Defense [W81XWH-06-1-0427]; US
Agency for International Development [W81XWH-06-1-0427]; University of
Maryland Multidisciplinary Clinical Research Career Development Program
(NIH) [K12RR023250]
FX This work was supported by the National Institute of Allergy and
Infectious Diseases (contract N01AI85346 and cooperative agreement
U19AI065683), the Fogarty International Center of the National
Institutes of Health (grant D43TW001589), both the US Department of
Defense and US Agency for International Development (contract
W81XWH-06-1-0427), the Howard Hughes Medical Institute and the Doris
Duke Charitable Foundation (support for training and genetics analysis),
and the University of Maryland Multidisciplinary Clinical Research
Career Development Program (NIH award K12RR023250 to S. T.-H.).
NR 28
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U1 2
U2 25
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD FEB 1
PY 2013
VL 207
IS 3
BP 511
EP 519
DI 10.1093/infdis/jis709
PG 9
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 066JH
UT WOS:000313216300020
PM 23204168
ER
PT J
AU Singer, GP
Hearn, AR
Chapman, ED
Peterson, ML
LaCivita, PE
Brostoff, WN
Bremner, A
Klimley, AP
AF Singer, Gabriel P.
Hearn, Alex R.
Chapman, Eric D.
Peterson, Matthew L.
LaCivita, Peter E.
Brostoff, William N.
Bremner, Allison
Klimley, A. P.
TI Interannual variation of reach specific migratory success for Sacramento
River hatchery yearling late-fall run Chinook salmon (Oncorhynchus
tshawytscha) and steelhead trout (Oncorhynchus mykiss)
SO ENVIRONMENTAL BIOLOGY OF FISHES
LA English
DT Article
DE Steelhead trout; Chinook salmon; Telemetry; Sacramento River; Migratory
success; San Francisco Estuary
ID LOWER SNAKE; SURVIVAL; CALIFORNIA; PROBABILITIES; ESTUARY; STOCKS;
DELTA; TIME
AB The release of hatchery reared salmonid smolts is a common management tool aimed at enhancing depleted wild stocks and maintaining fisheries throughout Northern California and the Pacific Northwest. In the Sacramento River watershed, smolts must migrate through the river, delta and estuary in order to successfully reach the Pacific Ocean. Migration success (success defined as apparent survival from one monitor location to another) may vary between species, year and habitat. We released 500 late-fall run Chinook salmon and 500 steelhead smolts in 2009 and 2010 in the Sacramento River (river kilometer 207). Each smolt was implanted with a coded ultrasonic tag, which was detected by an array of over 300 underwater receiver stations deployed throughout the system. Less than 25 % of fish migrated successfully to the Pacific Ocean in both years. We found that reach specific success was greater in the Delta in 2009 (> 60 %) than in 2010 (< 33 %), whereas this pattern was reversed in the Bay (< 57 % in 2009, > 75 % in 2010). Identifying the location, timing and causes of smolt mortality can lead to improved management of the resource.
C1 [Singer, Gabriel P.; Hearn, Alex R.; Chapman, Eric D.; Peterson, Matthew L.; Klimley, A. P.] Univ Calif Davis, Biotelemetry Lab, Dept Wildlife Fish & Conservat Biol, Davis, CA 95616 USA.
[LaCivita, Peter E.; Brostoff, William N.; Bremner, Allison] USA, Corps Engineers, San Francisco, CA 94103 USA.
RP Singer, GP (reprint author), Univ Calif Davis, Biotelemetry Lab, Dept Wildlife Fish & Conservat Biol, 1 Shields Ave, Davis, CA 95616 USA.
EM gsinger@ucdavis.edu
FU San Francisco Bay Long Term Management Study through the San Francisco
District of the United States Army Corps of Engineers
FX Funding for this project was provided by the San Francisco Bay Long Term
Management Study through the San Francisco District of the United States
Army Corps of Engineers. This project could not have been completed
without the help and support of the following people: Ethan Mora, Mike
Thomas, Phil Sandstrom, Cyril Michel, Arnold Ammann, Kurtis Brown, Scott
Hamelburg, David Woodbury and members of the California Fish Tracking
Consortium.
NR 36
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U1 3
U2 17
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0378-1909
J9 ENVIRON BIOL FISH
JI Environ. Biol. Fishes
PD FEB
PY 2013
VL 96
IS 2-3
BP 363
EP 379
DI 10.1007/s10641-012-0037-y
PG 17
WC Ecology; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA 064FU
UT WOS:000313059000019
ER
PT J
AU Moussa, HM
Melanson, MA
AF Moussa, Hanna M.
Melanson, Mark A.
TI TRANSLATION OF DOSE COEFFICIENTS FROM ICRP 53 TO ICRP 80
SO HEALTH PHYSICS
LA English
DT Article
DE P-33; biokinetics; dose equivalent; effective dose; dose; absorbed
AB The effective dose coefficients tabulated in Publication 80 of the International Commission on Radiological Protection (ICRP) for the radiopharmaceuticals addressed earlier in ICRP Publication 53 are based on the tissue weighting factors of ICRP Publication 60. Presumably these values are derived from the tissue dose coefficients tabulated in Publication 53; however, no details regarding their derivation are provided. The tissue weighting factors of Publication 60 explicitly address tissue for which no dose coefficients were tabulated in Publication 53; for example, esophagus and a number of tissues comprising the remainder. In the absence of guidance, the authors have defined a set of rules for the translation and have undertaken an effort to derive the effective dose coefficients of Publication 80 starting with the organ/tissue dose coefficient of Publication 53. Health Phys. 104(2): 224-226; 2013
C1 [Moussa, Hanna M.] Texas Tech Univ, Coll Human Sci, Lubbock, TX 79409 USA.
[Melanson, Mark A.] USA, Publ Hlth Command, ATTN MCHB TS OHP, Aberdeen Proving Ground, MD 21010 USA.
RP Moussa, HM (reprint author), Texas Tech Univ, Coll Human Sci, 1301 Akron,POB 41162, Lubbock, TX 79409 USA.
EM hanna.moussa@ttu.edu
NR 6
TC 0
Z9 1
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0017-9078
EI 1538-5159
J9 HEALTH PHYS
JI Health Phys.
PD FEB
PY 2013
VL 104
IS 2
BP 224
EP 226
DI 10.1097/HP.0b013e3182758035
PG 3
WC Environmental Sciences; Public, Environmental & Occupational Health;
Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical
Imaging
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Nuclear Science & Technology; Radiology, Nuclear Medicine &
Medical Imaging
GA 064VV
UT WOS:000313104400013
PM 23274826
ER
PT J
AU Ganesan, A
Krantz, EM
Hullsiek, KH
Riddle, MS
Weintrob, AC
Lalani, T
Okulicz, JF
Landrum, M
Agan, B
Whitman, TJ
Ross, MJ
Crum-Cianflone, NF
AF Ganesan, A.
Krantz, E. M.
Hullsiek, K. Huppler
Riddle, M. S.
Weintrob, A. C.
Lalani, T.
Okulicz, J. F.
Landrum, M.
Agan, B.
Whitman, T. J.
Ross, M. J.
Crum-Cianflone, N. F.
CA Infect Dis Clinical Res Program
TI Determinants of incident chronic kidney disease and progression in a
cohort of HIV-infected persons with unrestricted access to health care
SO HIV MEDICINE
LA English
DT Article
DE baseline CD4 count; ethnicity; highly active antiretroviral therapy; HIV
infection; kidney disease; socioeconomic status
ID STAGE RENAL-DISEASE; GLOMERULAR-FILTRATION-RATE; ACTIVE ANTIRETROVIRAL
THERAPY; ATHEROSCLEROSIS RISK; RACIAL-DIFFERENCES; NEPHROPATHY;
SPECTRUM; RECOMMENDATIONS; ASSOCIATION; COMMUNITIES
AB Objectives As socioeconomic factors may impact the risk of chronic kidney disease (CKD), we evaluated the incidence and risk factors of incident CKD among an HIV-infected cohort with universal access to health care and minimal injecting drug use (IDU). Methods Incident CKD was defined as an estimated glomerular filteration rate (eGFR) <60?ml/min/1.73?m2 for =?90 days. eGFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Rates were calculated per 1000 person-years (PY). Associations with outcomes were assessed using two separate Cox proportional hazard models, adjusting for baseline and time-updated covariates. Results Among 3360 participants [median age 29 years; 92% male; 44% African American (AA)] contributing 23?091 PY of follow-up, 116 developed incident CKD [5.0/1000 PY; 95% confidence interval (CI) 4.26.0/1000 PY]. The median first eGFR value was 97.0?mL/min/1.73?m2 [interquartile range (IQR) 85.3110.1?mL/min/1.73?m2]. Baseline factors associated with CKD included older age, lower CD4 count at HIV diagnosis [compared with CD4 count =?500 cells/mu L, hazard ratio (HR) 2.1 (95% CI 1.23.8) for CD4 count 350499 cells/mu L; HR 3.6 (95% CI 2.06.3) for CD4 count 201349 cells/mu L; HR 4.3 (95% CI 2.09.4) for CD4 count =?200 cells/mu L], and HIV diagnosis in the pre-highly active antiretroviral therapy (HAART) era. In the time-updated model, low nadir CD4 counts, diabetes, hepatitis B, hypertension and less HAART use were also associated with CKD. AA ethnicity was not associated with incident CKD in either model. Conclusions The low incidence of CKD and the lack of association with ethnicity observed in this study may in part be attributable to unique features of our cohort such as younger age, early HIV diagnosis, minimal IDU, and unrestricted access to care. Lower baseline CD4 counts were significantly associated with incident CKD, suggesting early HIV diagnosis and timely introduction of HAART may reduce the burden of CKD.
C1 [Ganesan, A.; Krantz, E. M.; Hullsiek, K. Huppler; Weintrob, A. C.; Lalani, T.; Okulicz, J. F.; Landrum, M.; Agan, B.; Whitman, T. J.; Crum-Cianflone, N. F.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
[Ganesan, A.] Natl Naval Med Ctr, Div Infect Dis, Bethesda, MD 20889 USA.
[Krantz, E. M.; Hullsiek, K. Huppler] Univ Minnesota, Minneapolis, MN USA.
[Weintrob, A. C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
[Lalani, T.] USN, Med Ctr Portsmouth, Portsmouth, VA USA.
[Okulicz, J. F.; Landrum, M.] San Antonio Mil Med Ctr, San Antonio, TX USA.
[Ross, M. J.] Mt Sinai Sch Med, New York, NY USA.
[Crum-Cianflone, N. F.] USN, San Diego Med Ctr, San Diego, CA 92152 USA.
[Crum-Cianflone, N. F.] USN, Hlth Res Ctr, San Diego, CA 92152 USA.
RP Ganesan, A (reprint author), Natl Naval Med Ctr, Div Infect Dis, 8901 Wisconsin Ave, Bethesda, MD 20889 USA.
EM anuradha.ganesan@med.navy.mil
OI Polis, Michael/0000-0002-9151-2268; Agan, Brian/0000-0002-5114-1669
FU Infectious Disease Clinical Research Program (IDCRP), a Department of
Defense (DoD) programme executed through the Uniformed Services
University of the Health Sciences [IDCRP-015]; National Institute of
Allergy and Infectious Diseases, National Institutes of Health (NIH)
[Y1-AI-5072]
FX We would like to thank the participants and their caregivers, without
whom none of this work would be possible. We would also like to thank
the research coordinators and support staff who have diligently worked
on the Department of Defense HIV Natural History Study, as well as the
members of the Infectious Disease Clinical Research Program HIV Working
Group, listed in the Appendix. Support for this work (IDCRP-015) was
provided by the Infectious Disease Clinical Research Program (IDCRP), a
Department of Defense (DoD) programme executed through the Uniformed
Services University of the Health Sciences. This project has been funded
in whole, or in part, with federal funds from the National Institute of
Allergy and Infectious Diseases, National Institutes of Health (NIH),
under Inter-Agency Agreement Y1-AI-5072.
NR 42
TC 8
Z9 8
U1 0
U2 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1464-2662
J9 HIV MED
JI HIV Med.
PD FEB
PY 2013
VL 14
IS 2
BP 65
EP 76
DI 10.1111/j.1468-1293.2012.01036.x
PG 12
WC Infectious Diseases
SC Infectious Diseases
GA 063KV
UT WOS:000312998300001
PM 22808988
ER
PT J
AU Yang, Y
Liou, WW
Sheng, J
Gorsich, D
Arepally, S
AF Yang, Yang
Liou, William W.
Sheng, James
Gorsich, David
Arepally, Sudhakar
TI Shock wave impact simulation of a vehicle occupant using
fluid/structure/dynamics interactions
SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING
LA English
DT Article
DE Blast wave; Fluid-structure interactions; Vehicle occupant safety
ID PLATES
AB Ground vehicles subjected to blast can result in vehicle movements and occupant injuries. The engineering mechanisms involved in such blasts include fluid dynamics, solid dynamics, and multi-body dynamics. This paper describes a parallel computer simulation methodology that can be applied to couple the structural deformation prediction of a ground vehicle system and the associated occupant kinematics during a blast event. Generic box and dummy models were used in the demonstration of this newly-developed methodology. The generic system structure consists of an outer cube representing a vehicle armor structure, and a dummy representing a crew member in a ground vehicle. Simulation results for different cases include free air blast wave propagation, blast on a metal plate and over a hemispherical dome, and blast wave interaction with a vehicle and its occupant inside. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Yang, Yang; Liou, William W.] Western Michigan Univ, Kalamazoo, MI 49008 USA.
[Sheng, James; Gorsich, David; Arepally, Sudhakar] USA, RDECOM, TARDEC, Warren, MI 48397 USA.
RP Yang, Y (reprint author), Western Michigan Univ, Kalamazoo, MI 49008 USA.
EM yang.yang@wmich.edu
RI Yang, Yang/A-2499-2011
OI Yang, Yang/0000-0002-7989-2843
FU U.S. Army TACOM Life Cycle Command through Mississippi State University
[W56HZV-08-C-0236]
FX This material is based upon work supported by the U.S. Army TACOM Life
Cycle Command under Contract No. W56HZV-08-C-0236, through a subcontract
with Mississippi State University, and was performed for the Simulation
Based Reliability and Safety (SimBRS) research program. Any opinions,
findings and conclusions or recommendations expressed in this material
are those of the author(s) and do not necessarily reflect the views of
the U.S. Army TACOM Life Cycle Command.
NR 23
TC 1
Z9 3
U1 0
U2 25
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0734-743X
J9 INT J IMPACT ENG
JI Int. J. Impact Eng.
PD FEB
PY 2013
VL 52
BP 11
EP 22
DI 10.1016/j.ijimpeng.2012.09.002
PG 12
WC Engineering, Mechanical; Mechanics
SC Engineering; Mechanics
GA 056QK
UT WOS:000312506000002
ER
PT J
AU Ainsworth, CR
Pamplin, JC
Allen, DA
Linfoot, JA
Chung, KK
AF Ainsworth, Craig R.
Pamplin, Jeremy C.
Allen, David A.
Linfoot, John A.
Chung, Kevin K.
TI A bedside communication tool did not improve the alignment of a
multidisciplinary team's goals for intensive care unit patients
SO JOURNAL OF CRITICAL CARE
LA English
DT Article
DE Goals; Multi-disciplinary; Communications; Process improvement;
Intensive care
ID MEDICAL ERROR; SAFETY; EVENTS
AB Purpose: Establishing well-understood daily patient care goals should improve healthcare team (HCT) communication, reduce errors, and improve patient outcomes. The purpose of this study was to test the hypothesis that implementation of a daily goals "Door Communication Card" (DCC) would improve goal alignment between members of the HCT.
Methods: As part of a process improvement project, HCT members listed their top care goals for a patient on a given day. After initial data collection, DCCs were placed on patients' doors. Anyone was allowed to write on the card, but the "official" daily goals were recorded during multidisciplinary rounds. One month after introduction of the DCC, HCT members were re-queried about their patients' care goals. Three reviewers independently compared goals and assessed their alignment before and after implementation of the DCC. We collected goals over a 4-month period and selected 5 random days before and after intervention for assessment.
Results: The goal alignment among HCT members was low before and did not improve after intervention (Attending-to-Nurse 55% vs 38%, P = .02; Attending-to-Resident 60% vs 54%, P = .43; Attending-to-Primary 35% vs 28%, P = .45; Nurse-to-Attending 52% vs 36%, P = .03; Nurse-to-Resident 55% vs 38%, P = .04; Nurse-to-Primary 37% vs 27%, P = .36; Resident-to-Attending 59% vs 54%, P = .4; Resident-to-Nurse 56% vs 40%, P = .05; Resident-to-Primary 36% vs 24%, P = .16; Primary-to-Attending 34% vs 42%, P = .44; Primary-to-Nurse 42% vs 35%, P = .6; Primary-to-Resident 32% vs 34%, P = .8).
Conclusions: Alignment of daily patient care goals among HCT members is low overall and did not improve after implementing a DCC available to all team members. Further study to elucidate the mechanism by which daily goals forms improve patient care is required. Published by Elsevier Inc.
C1 [Ainsworth, Craig R.] Walter Reed Natl Mil Med Ctr, Bethesda, MD 20889 USA.
[Pamplin, Jeremy C.; Linfoot, John A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
[Allen, David A.; Chung, Kevin K.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Ainsworth, CR (reprint author), 16573 Sioux Lane, Gaithersburg, MD 20878 USA.
NR 16
TC 1
Z9 1
U1 1
U2 10
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0883-9441
J9 J CRIT CARE
JI J. Crit. Care
PD FEB
PY 2013
VL 28
IS 1
AR 112.e7
DI 10.1016/j.jcrc.2012.09.006
PG 7
WC Critical Care Medicine
SC General & Internal Medicine
GA 062UY
UT WOS:000312949700024
PM 23159135
ER
PT J
AU McAllister, QP
Gillespie, JW
VanLandingham, MR
AF McAllister, Quinn P.
Gillespie, John W., Jr.
VanLandingham, Mark R.
TI The influence of surface microstructure on the scratch characteristics
of Kevlar fibers
SO JOURNAL OF MATERIALS SCIENCE
LA English
DT Article
ID ATOMIC-FORCE MICROSCOPY; POLY(PARA-PHENYLENE TEREPHTHALAMIDE) FIBERS;
POLY(P-PHENYLENE TEREPHTHALAMIDE); BIOPOLYMER FIBERS; ARAMID FABRICS;
POLYMER; DEFORMATION; RESISTANCE; FRICTION; COATINGS
AB In this work, nanoindentation and nanoscratching experiments are combined with atomic force microscopy to investigate the relationships between contact geometry, apparent friction, and deformation modes of two grades of Kevlar (R) (Dupont) fiber-Kevlar KM2 and Kevlar 49. Changes in the relative angle between the scratching probe and the fiber surface, often termed as the attack angle, result in changes in deformation mode, which correlate with the changes in the apparent friction. As attack angle increases, the observed deformation modes of the fiber surface change from a smoothing of the surface, often termed as ironing, to fibrillation, in which the fibrils break and coalesce in front of the progressing probe. A mixture of these two modes occurs at intermediate attack angles. When fibrillation occurs, material pile-up forms in front of the progressing probe. This pile-up introduces an additional component to the frictional response that is largely responsible for an increase in apparent friction with an increasing attack angle and/or scratch length. The level of friction associated with fibrillation is measured to be up to approximately three times higher than previously reported for Kevlar yarn-yarn friction. Fibrillation of Kevlar KM2 occurs at larger attack angles as compared to Kevlar 49, which is believed to be related to a near-surface region of reduced modulus and hardness previously observed in KM2 fibers. A detailed discussion of the measured response is given based on the interactions between the scratching probe and the fibrillar network and the resulting deformation mechanisms.
C1 [McAllister, Quinn P.; Gillespie, John W., Jr.] Univ Delaware, Ctr Composite Mat, Dept Mat Sci & Engn, Newark, DE 19716 USA.
[VanLandingham, Mark R.] USA, Mat & Mfg Sci Div, Weap & Mat Res Directorate, Res Lab,ATTN RDRL WMM B, Aberdeen, MD 21005 USA.
RP Gillespie, JW (reprint author), Univ Delaware, Ctr Composite Mat, Dept Mat Sci & Engn, Newark, DE 19716 USA.
EM mcallq@udel.edu; gillespi@udel.edu
FU Army Research Laboratory [W911NF-06-2-0011]
FX QM and JWG gratefully acknowledge the sponsorship by the Army Research
Laboratory under cooperative agreement W911NF-06-2-0011. The views and
conclusions contained in this paper should not be interpreted as
representing the official policies, either expressed or implied, of the
Army Research Laboratory or the U.S. Government. The U.S. Government is
authorized to reproduce and distribute reprints for Government purposes
not withstanding any copyright notation herein.
NR 47
TC 2
Z9 2
U1 3
U2 70
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0022-2461
J9 J MATER SCI
JI J. Mater. Sci.
PD FEB
PY 2013
VL 48
IS 3
BP 1292
EP 1302
DI 10.1007/s10853-012-6872-6
PG 11
WC Materials Science, Multidisciplinary
SC Materials Science
GA 062FO
UT WOS:000312904900038
ER
PT J
AU Fernandez, S
Cromer, LD
Borntrager, C
Swopes, R
Hanson, RF
Davis, JL
AF Fernandez, Shantel
Cromer, Lisa DeMarni
Borntrager, Cameo
Swopes, Rachael
Hanson, Rochelle F.
Davis, Joanne L.
TI A Case Series: Cognitive-Behavioral Treatment (Exposure, Relaxation, and
Rescripting Therapy) of Trauma-Related Nightmares Experienced by
Children
SO CLINICAL CASE STUDIES
LA English
DT Article
DE sleep problems; dreams; posttraumatic stress; treatment
ID POSTTRAUMATIC-STRESS-DISORDER; RANDOMIZED CLINICAL-TRIAL; SCHOOL-AGED
CHILDREN; IMAGERY REHEARSAL; SLEEP DISORDERS; ANXIETY; INSTRUMENT;
DEPRESSION; CHILDHOOD; SYMPTOMS
AB Two case studies are presented to demonstrate that children who experience trauma-related nightmares may benefit from cognitive-behavioral therapy for this sleep problem. The treatment was adapted from the empirically supported adult treatment for chronic trauma-related nightmares: exposure, relaxation, and rescripting therapy (ERRT). Pretreatment and posttreatment nightmare frequency and severity were measured in addition to subjective nightmare-related distress, behavioral problems, sleep quality and quantity, and symptoms of posttraumatic stress disorder (PTSD), anxiety, and depression. Improvement in nightmare and sleep disturbance frequencies were found as well as reductions in parents' reports of child behavior problems. This study provides preliminary support for the use of ERRT with children.
C1 [Fernandez, Shantel] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
[Cromer, Lisa DeMarni; Swopes, Rachael; Davis, Joanne L.] Univ Tulsa, Tulsa, OK 74104 USA.
[Borntrager, Cameo] Univ Montana, Missoula, MT 59812 USA.
[Hanson, Rochelle F.] Med Univ S Carolina, Charleston, SC USA.
RP Fernandez, S (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM shantel.fernandez@us.army.mil
NR 56
TC 2
Z9 2
U1 1
U2 7
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-6501
EI 1552-3802
J9 CLIN CASE STUD
JI Clin. Case Stud.
PD FEB
PY 2013
VL 12
IS 1
BP 39
EP 59
DI 10.1177/1534650112462623
PG 21
WC Psychology, Clinical; Psychiatry
SC Psychology; Psychiatry
GA AW9OL
UT WOS:000346586800003
ER
PT J
AU Muramatsu, RS
AF Muramatsu, Russ S.
TI Untitled
SO MILITARY MEDICINE
LA English
DT Letter
C1 Tripler Army Med Ctr, Honolulu, HI 96859 USA.
RP Muramatsu, RS (reprint author), Tripler Army Med Ctr, Honolulu, HI 96859 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD FEB
PY 2013
VL 178
IS 2
BP IV
EP IV
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7TW
UT WOS:000340804900002
PM 23495453
ER
PT J
AU Jones, DE
Jones, F
Suttinger, L
Toler, A
Hammond, P
Medina, S
AF Jones, David E.
Jones, Franca
Suttinger, Laura
Toler, Ayessa
Hammond, Patricia
Medina, Steven
TI Placement of Combat Stress Teams in Afghanistan: Reducing Barriers to
Care
SO MILITARY MEDICINE
LA English
DT Editorial Material
AB This article describes the medical planning process whereby combat stress and mental health clinicians were placed at Forward Operating Bases in southern and western Afghanistan during a period of intensive surge operations in 2009-2010. The distribution plan for the Combat Stress Control teams was based on previously published guidance on ratios of combat stress personnel to troop end-strength, population at-risk data, and kinetic activity associated with current and future combat operations. The article concludes with outcome data that validates the distribution decisions made through the planning process. Through dissemination of this information, it is hoped that future planners and clinicians can improve the processes involved in providing combat stress and mental health services to forward-deployed troops.
C1 [Jones, David E.] Naval Med Ctr Portsmouth, Portsmouth, VA 23708 USA.
[Jones, Franca] Naval Med Res Ctr, Silver Spring, MD 20910 USA.
[Suttinger, Laura] 467th Med Detachment Combat Stress Control, Madison, WI 53715 USA.
[Toler, Ayessa] CNO OPNAV, Med Resources Plans & Policy Div N931, Washington, DC 20350 USA.
[Hammond, Patricia] US Army John F Kennedy Special Warfare Ctr & Sch, ATTN AOJK GRP, Ft Bragg, NC 28310 USA.
[Medina, Steven] NAS JRB, RC Fleet Hosp 15, Ft Worth, TX 76127 USA.
RP Jones, DE (reprint author), Naval Med Ctr Portsmouth, 620 John Paul Jones Circle, Portsmouth, VA 23708 USA.
NR 4
TC 1
Z9 1
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD FEB
PY 2013
VL 178
IS 2
BP 121
EP 125
DI 10.7205/MILMED-D-12-00163
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7TW
UT WOS:000340804900003
PM 23495454
ER
PT J
AU Rivers, FM
Gordon, S
Speraw, S
Reese, S
AF Rivers, Felecia M.
Gordon, Sandra
Speraw, Susan
Reese, Sharon
TI US Army Nurses' Reintegration and Homecoming Experiences After Iraq and
Afghanistan
SO MILITARY MEDICINE
LA English
DT Article
ID MILITARY PERSONNEL; FAMILIES; WARTIME; RISK
AB Objective: The aim of this study was to understand U.S. Army nurses' reintegration and homecoming experiences after deployment to Iraq or Afghanistan. Method: Employing existential phenomenology and purposive sampling, 22 U.S. Army active duty nurses were recruited from two military posts and participated in single digitally recorded interviews. Results: Five themes emerged: (1) aspects of command support were articulated as "No One Cares"; (2) fulfilling requirements for attendance at pre/postdeployment briefings were described as merely "Check the Blocks"; (3) readjustments from focusing strictly on duty requirements versus multitasking, such as family responsibilities and daily living, led to the "Stress of Being Home"; (4) nurses stated "They Don't Understand" when referring to anyone without deployment experience (family, friends, other soldiers); and (5) when referencing deployment experiences, nurses emphasized that, "It Just Changes You." Discussion: Nurses in this study felt that the current reintegration process was not meeting their needs for a smoother homecoming; new or improved interventions to assist redeploying nurses with the transition to a noncombat environment would be beneficial. Educational programs to help nursing supervisors provide optimal leadership support through all phases of deployment are needed.
C1 [Rivers, Felecia M.] Womack Army Med Ctr, Ft Bragg, NC 28310 USA.
[Gordon, Sandra] Carl R Darnall Army Med Ctr, Ft Hood, TX 76544 USA.
[Speraw, Susan] Univ Tennessee, Coll Nursing, Knoxville, TN 37996 USA.
[Reese, Sharon] Baylor Univ, Sch Social Work, Waco, TX 76798 USA.
RP Rivers, FM (reprint author), Womack Army Med Ctr, 2817 Reilly Rd, Ft Bragg, NC 28310 USA.
FU TriService Nursing Research Program [HU0001-10-1-TS16 (N10-C03)]
FX This study was funded by the TriService Nursing Research Program, Grant
Number HU0001-10-1-TS16 (N10-C03).
NR 20
TC 4
Z9 4
U1 0
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD FEB
PY 2013
VL 178
IS 2
BP 166
EP 173
DI 10.7205/MILMED-D-12-00279
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7TW
UT WOS:000340804900011
PM 23495462
ER
PT J
AU Recupero, A
Mahnke, CB
Pinsker, JE
AF Recupero, Anthony
Mahnke, C. Becket
Pinsker, Jordan E.
TI Emerging Technology in Diabetes Care: The Real-Time Diabetes Monitoring
System
SO MILITARY MEDICINE
LA English
DT Article
ID SELF-MANAGEMENT; MELLITUS; OUTCOMES; PROJECT
AB The majority of telemedicine interventions for diabetes have failed to show objective improvements in outcomes. We describe the Real-Time Diabetes Monitoring System (RT-DMS), which augments our successful telemedicine system for pediatric patients with type 1 diabetes by allowing automated uploads of glucometer readings. The addition of automatic transfer of glucometer readings enables RT-DMS to improve patient compliance and increases monitoring by physicians. The system is scalable for use by both children and adults with all forms of diabetes and has the potential to significantly improve clinic workflow, allowing RT-DMS to serve as a model for managing chronic disease using telemedicine.
C1 [Recupero, Anthony] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA.
[Mahnke, C. Becket; Pinsker, Jordan E.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA.
RP Recupero, A (reprint author), Uniformed Serv Univ Hlth Sci, Dept Pediat, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
OI Pinsker, Jordan/0000-0003-4080-9034
FU U.S. Army Public Health Command through the Health Promotion and
Prevention Initiatives (HPPI) program
FX The authors thank Eludrizza Tabisola-Nuesca, RN, CDE and Debora Chan,
PharmD for their assistance in setting up the TAMC RT-DMS. Resource
support for this project was provided by the U.S. Army Public Health
Command (formerly the U.S. Army Center for Health Promotion and
Preventive Medicine) through the Health Promotion and Prevention
Initiatives (HPPI) program.
NR 15
TC 3
Z9 3
U1 1
U2 3
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD FEB
PY 2013
VL 178
IS 2
BP 218
EP 221
DI 10.7205/MILMED-D-12-00317
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7TW
UT WOS:000340804900018
PM 23495469
ER
PT J
AU Tarney, CM
Whitecar, P
Sewell, M
Grubish, L
Hope, E
AF Tarney, Christopher M.
Whitecar, Paul
Sewell, Mark
Grubish, Lindsay
Hope, Erica
TI Rupture of an Unscarred Uterus in a Quadruplet Pregnancy
SO OBSTETRICS AND GYNECOLOGY
LA English
DT Article
AB BACKGROUND: Uterine rupture of an unscarred uterus is a rare complication in a quadruplet pregnancy.
CASE: A 30-year-old woman, gravida 4 para 0030, with a quadruplet pregnancy and no previous uterine surgeries presented with moderate vaginal bleeding at 32 4/7 weeks of gestation. Fetal testing was reassuring, and the cervix showed no signs of preterm labor. A decision was made to proceed with cesarean delivery because of the amount of vaginal bleeding, with surgical findings of uterine rupture superior to the lower uterine segment.
CONCLUSION: High-order gestations may be an independent risk factor for uterine rupture.
C1 [Tarney, Christopher M.] Womack Army Med Ctr, Dept Obstet & Gynecol, Ft Bragg, NC 28307 USA.
Walter Reed Natl Mil Med Ctr, Dept Obstet & Gynecol, Bethesda, MD USA.
RP Tarney, CM (reprint author), Womack Army Med Ctr, Dept Obstet & Gynecol, 2817 Reilly Rd, Ft Bragg, NC 28307 USA.
EM christopher.tarney@us.army.mil
NR 8
TC 3
Z9 4
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0029-7844
EI 1873-233X
J9 OBSTET GYNECOL
JI Obstet. Gynecol.
PD FEB
PY 2013
VL 121
IS 2
BP 483
EP 485
DI 10.1097/AOG.0b013e31827c603c
PN 2
PG 4
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 300IZ
UT WOS:000330458900024
PM 23344417
ER
PT J
AU Razumovsky, A
Tigno, T
Kouperberg, E
Bell, R
Severson, MV
Hochheimer, SM
Marshall, SA
Aden, J
Oppenheimer, SM
Ecker, R
Armonda, RA
AF Razumovsky, Alexander
Tigno, Teodore
Kouperberg, Efim
Bell, Randy
Severson, Meryl V.
Hochheimer, Sven M.
Marshall, Scott A.
Aden, James
Oppenheimer, Stephen M.
Ecker, Robert
Armonda, Rocco A.
TI Cerebral Hemodynamic Changes in Patients with Wartime Traumatic Brain
Unjury
SO STROKE
LA English
DT Meeting Abstract
CT American-Heart-Association/American-Stroke-Association International
Stroke Conference / Nursing Symposium
CY FEB 06-08, 2013
CL Honolulu, HI
SP Amer Heart Assoc, Amer Stroke Assoc
DE Cerebrovascular circulation; Blood flow; Vasoconstriction; Doppler
ultrasound; Patient care
C1 [Razumovsky, Alexander; Kouperberg, Efim; Oppenheimer, Stephen M.] Sentient NeuroCare Serv, Hunt Valley, MD USA.
[Tigno, Teodore; Bell, Randy; Hochheimer, Sven M.; Armonda, Rocco A.] Walter Reed Natl Mil Med Cntr, Bethesda, MD USA.
[Severson, Meryl V.] Walter Reed Natl Mil, Hunt Valley, MD USA.
[Marshall, Scott A.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Aden, James] US Army Inst Surg Res, Houston, TX USA.
[Ecker, Robert] Maine Med Cntr, Portland, ME USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0039-2499
EI 1524-4628
J9 STROKE
JI Stroke
PD FEB
PY 2013
VL 44
IS 2
SU S
PG 1
WC Clinical Neurology; Peripheral Vascular Disease
SC Neurosciences & Neurology; Cardiovascular System & Cardiology
GA 301NY
UT WOS:000330540200054
ER
PT J
AU Eikenberry, KW
AF Eikenberry, Karl W.
TI Reassessing the All-Volunteer Force
SO WASHINGTON QUARTERLY
LA English
DT Article
C1 [Eikenberry, Karl W.] Stanford Univ, Stanford, CA 94305 USA.
[Eikenberry, Karl W.] USA, Washington, DC USA.
RP Eikenberry, KW (reprint author), Stanford Univ, Stanford, CA 94305 USA.
NR 40
TC 2
Z9 2
U1 0
U2 2
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0163-660X
J9 WASH QUART
JI Wash. Q.
PD FEB 1
PY 2013
VL 36
IS 1
BP 7
EP 24
DI 10.1080/0163660X.2013.751647
PG 18
WC International Relations; Law
SC International Relations; Government & Law
GA 055YE
UT WOS:000312453100001
ER
PT J
AU Bednar, AJ
Poda, AR
Mitrano, DM
Kennedy, AJ
Gray, EP
Ranville, JF
Hayes, CA
Crocker, FH
Steevens, JA
AF Bednar, A. J.
Poda, A. R.
Mitrano, D. M.
Kennedy, A. J.
Gray, E. P.
Ranville, J. F.
Hayes, C. A.
Crocker, F. H.
Steevens, J. A.
TI Comparison of on-line detectors for field flow fractionation analysis of
nanomaterials
SO TALANTA
LA English
DT Article
DE Nanomaterials; Detection; Sizing; Field flow fractionation; ICP-MS;
ICP-AES
ID PLASMA-MASS-SPECTROMETRY; DYNAMIC LIGHT-SCATTERING; ENGINEERED
NANOPARTICLES; SILVER NANOPARTICLES; MEMBRANE FILTRATION; GOLD
NANOPARTICLES; NATURAL COLLOIDS; AQUATIC COLLOIDS; SIZE; ENVIRONMENT
AB Characterization of nanomaterials must include analysis of both size and chemical composition. Many analytical techniques, such as dynamic light scattering (DLS), are capable of measuring the size of suspended nanometer-sized particles, yet provide no information on the composition of the particle. While field flow fractionation (FFF) is a powerful nanoparticle sizing technique, common detectors used in conjunction with the size separation, including UV, light-scattering, and fluorescence spectroscopy, do not provide the needed particle compositional information. Further, these detectors do not respond directly to the mass concentration of nanoparticles. The present work describes the advantages achieved when interfacing sensitive and elemental specific detectors, such as inductively coupled plasma atomic emission spectroscopy and mass spectrometry, to FFF separation analysis to provide high resolution nanoparticle sizing and compositional analysis at the mu g/L concentration level, a detection at least 10-100-fold lower than DLS or FFF-UV techniques. The full benefits are only achieved by utilization of all detector capabilities, such as dynamic reaction cell (DRC) ICP-MS. Such low-level detection and characterization capability is critical to nanomaterial investigations at biologically and environmentally relevant concentrations. The techniques have been modified and applied to characterization of all four elemental constituents of cadmium selenide-zinc sulfide core-shell quantum dots, and silver nanoparticles with gold seed cores. Additionally, sulfide coatings on silver nanoparticles can be detected as a potential means to determine environmental aging of nanoparticles. Published by Elsevier B.V.
C1 [Bednar, A. J.; Poda, A. R.; Kennedy, A. J.; Crocker, F. H.; Steevens, J. A.] USA, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
[Mitrano, D. M.; Ranville, J. F.] Colorado Sch Mines, Dept Chem & Geochem, Golden, CO 80401 USA.
[Gray, E. P.] Colorado Sch Mines, Dept Civil & Environm Engn, Golden, CO 80401 USA.
[Hayes, C. A.] Badger Tech Serv, Vicksburg, MS 39180 USA.
RP Bednar, AJ (reprint author), USA, Engn Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM anthony.J.Bednar@usace.army.mil
RI Poda, Aimee/K-1905-2012;
OI ranville, james/0000-0002-4347-4885
NR 55
TC 37
Z9 38
U1 4
U2 99
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0039-9140
J9 TALANTA
JI Talanta
PD JAN 30
PY 2013
VL 104
BP 140
EP 148
DI 10.1016/j.talanta.2012.11.008
PG 9
WC Chemistry, Analytical
SC Chemistry
GA 149HZ
UT WOS:000319310900022
PM 23597901
ER
PT J
AU Gordon, SM
Franaszczuk, PJ
Hairston, WD
Vindiola, M
McDowell, K
AF Gordon, S. M.
Franaszczuk, P. J.
Hairston, W. D.
Vindiola, M.
McDowell, K.
TI Comparing parametric and nonparametric methods for detecting phase
synchronization in EEG
SO JOURNAL OF NEUROSCIENCE METHODS
LA English
DT Article
DE Phase synchronization; Autoregressive modeling; EEG
ID VOLUME-CONDUCTION; DYNAMICS; MODEL; SEPARATION; ARTIFACTS; COHERENCY;
SIGNALS; INDEX; BIAS
AB Detecting significant periods of phase synchronization in EEG recordings is a non-trivial task that is made especially difficult when considering the effects of volume conduction and common sources. In addition, EEG signals are often confounded by non-neural signals, such as artifacts arising from muscle activity or external electrical devices. A variety of phase synchronization analysis methods have been developed with each offering a different approach for dealing with these confounds. We investigate the use of a parametric estimation of the time-frequency transform as a means of improving the detection capability for a range of phase analysis methods. We argue that such an approach offers numerous benefits over using standard nonparametric approaches. We then demonstrate the utility of our technique using both simulated and actual EEG data by showing that the derived phase synchronization estimates are more robust to noise and volume conduction effects. (c) 2012 Elsevier B.V. All rights reserved.
C1 [Gordon, S. M.] DCS Corp, Alexandria, VA 22310 USA.
[Franaszczuk, P. J.; Hairston, W. D.; McDowell, K.] USA, Human Res & Engn Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Vindiola, M.] DRC High Performance Technol Grp, Reston, VA 20190 USA.
[Vindiola, M.] Computat & Informat Sci Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Gordon, SM (reprint author), DCS Corp, Alexandria, VA 22310 USA.
EM sgordon@dcscorp.com
RI Franaszczuk, Piotr/B-6532-2008
OI Franaszczuk, Piotr/0000-0002-5166-4224
FU Army Research Laboratory [W911NF-10-2-0022]
FX The authors would like to thank Jean Vettel of the Army Research
Laboratory for helpful discussions and directions with respect to the
generation and analysis of simulation data. This research was sponsored
by the Army Research Laboratory and was accomplished under Cooperative
Agreement Number W911NF-10-2-0022. The views and conclusions contained
in this document are those of the authors and should not be interpreted
as representing official policies, either expressed or implied, of the
Army Research Laboratory or the U.S. Government. The U.S. Government is
authorized to reproduce and distribute reprints for Government purposes
notwithstanding any copyright notation herein.
NR 29
TC 6
Z9 6
U1 0
U2 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0270
J9 J NEUROSCI METH
JI J. Neurosci. Methods
PD JAN 30
PY 2013
VL 212
IS 2
BP 247
EP 258
DI 10.1016/j.jneumeth.2012.10.002
PG 12
WC Biochemical Research Methods; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 104EJ
UT WOS:000315974200011
PM 23085564
ER
PT J
AU Kota, KP
Eaton, B
Lane, D
Ulrich, M
Ulrich, R
Peyser, BD
Robinson, CG
Jaissle, JG
Pegoraro, G
Bavari, S
Panchal, RG
AF Kota, Krishna P.
Eaton, Brett
Lane, Douglas
Ulrich, Melanie
Ulrich, Ricky
Peyser, Brian D.
Robinson, Camenzind G.
Jaissle, James G.
Pegoraro, Gianluca
Bavari, Sina
Panchal, Rekha G.
TI Integrating High-Content Imaging and Chemical Genetics to Probe Host
Cellular Pathways Critical for Yersinia Pestis Infection
SO PLOS ONE
LA English
DT Article
ID NF-KAPPA-B; EPITHELIAL-CELLS; PNEUMONIC PLAGUE; MACROPHAGES; INVASION;
MICE; PATHOGENESIS; APOPTOSIS; RNAI; PHENOTHIAZINES
AB The molecular machinery that regulates the entry and survival of Yersinia pestis in host macrophages is poorly understood. Here, we report the development of automated high-content imaging assays to quantitate the internalization of virulent Y. pestis CO92 by macrophages and the subsequent activation of host NF-kappa B. Implementation of these assays in a focused chemical screen identified kinase inhibitors that inhibited both of these processes. Rac-2-ethoxy-3 octadecanamido-1-propylphosphocholine (a protein Kinase C inhibitor), wortmannin (a PI3K inhibitor), and parthenolide (an I kappa B kinase inhibitor), inhibited pathogen-induced NF-kappa B activation and reduced bacterial entry and survival within macrophages. Parthenolide inhibited NF-kappa B activation in response to stimulation with Pam3CSK4 (a TLR2 agonist), E. coli LPS (a TLR4 agonist) or Y. pestis infection, while the PI3K and PKC inhibitors were selective only for Y. pestis infection. Together, our results suggest that phagocytosis is the major stimulus for NF-kappa B activation in response to Y. pestis infection, and that Y. pestis entry into macrophages may involve the participation of protein kinases such as PI3K and PKC. More importantly, the automated image-based screening platform described here can be applied to the study of other bacteria in general and, in combination with chemical genetic screening, can be used to identify host cell functions facilitating the identification of novel antibacterial therapeutics.
C1 [Eaton, Brett; Ulrich, Melanie; Ulrich, Ricky; Bavari, Sina; Panchal, Rekha G.] USA, Med Res Inst Infect Dis, Dept Target Discovery & Cellular Microbiol, Frederick, MD USA.
[Kota, Krishna P.; Pegoraro, Gianluca] Perkin Elmer, Waltham, MA USA.
[Lane, Douglas; Peyser, Brian D.] NCI Frederick, SAIC Frederick, Target Struct Based Drug Discovery Grp, Frederick, MD USA.
[Robinson, Camenzind G.] USA, Med Res Inst Infect Dis, Div Pathol, Frederick, MD USA.
[Jaissle, James G.] USA, Med Res Inst Infect Dis, Diagnost Syst Div, Frederick, MD USA.
RP Panchal, RG (reprint author), USA, Med Res Inst Infect Dis, Dept Target Discovery & Cellular Microbiol, Frederick, MD USA.
EM rekha.panchal@amedd.army.mil
OI Pegoraro, Gianluca/0000-0003-2843-9464; Peyser,
Brian/0000-0002-3455-5181
FU Department of Defense Chemical Biological Defense Program through the
Defense Threat Reduction Agency (DTRA) [JSTO-CBD 2.10019_09_RD_B];
National Cancer Institute, National Institutes of Health [N01-CO-12400];
Developmental Therapeutics Program in the Division of Cancer Treatment
and Diagnosis of the National Cancer Institute
FX This project was funded by the Department of Defense Chemical Biological
Defense Program through the Defense Threat Reduction Agency (DTRA)
JSTO-CBD 2.10019_09_RD_B (to RGP). This project has been funded in whole
or in part with federal funds from the National Cancer Institute,
National Institutes of Health, under contract N01-CO-12400. This
research was supported, in part, by the Developmental Therapeutics
Program in the Division of Cancer Treatment and Diagnosis of the
National Cancer Institute. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
NR 51
TC 2
Z9 2
U1 0
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 30
PY 2013
VL 8
IS 1
AR e55167
DI 10.1371/journal.pone.0055167
PG 15
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 098QM
UT WOS:000315563800125
PM 23383093
ER
PT J
AU McLaughlin, MP
Adduci, LL
Becker, JJ
Gagne, MR
AF McLaughlin, Matthew P.
Adduci, Laura L.
Becker, Jennifer J.
Gagne, Michel R.
TI Iridium-Catalyzed Hydrosilylative Reduction of Glucose to Hexane(s)
SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Article
ID C-GLYCOSYL COMPOUNDS; CARBON-MONOXIDE; BIOMASS; DEOXYGENATION;
COMPLEXES; ALCOHOLS; ETHERS; 1,2-PROPANEDIOL; HYDROGENOLYSIS; CONVERSION
AB In light of diminishing petroleum feed-stocks, there is significant interest in developing carbohydrate defunctionalization reactions. In this context we have examined the use of iridium pincer catalysts for the hydrosilylative reduction of sugars, and we report herein complete reduction of silyl-protected glucose to a mixture of hexane isomers.
C1 [McLaughlin, Matthew P.; Adduci, Laura L.; Gagne, Michel R.] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA.
[Becker, Jennifer J.] USA, Res Off, Res Triangle Pk, NC 27709 USA.
RP Gagne, MR (reprint author), Univ N Carolina, Dept Chem, CB 3290, Chapel Hill, NC 27599 USA.
EM mgagne@unc.edu
FU National Research Council; UNC Institute for the Environment/Progress
Energy Foundation; Department of Energy [FG02-05ER15630]; Army Research
Office
FX M.P.M. thanks the National Research Council for a postdoctoral
fellowship, L.L.A. thanks the UNC Institute for the Environment/Progress
Energy Foundation for a fellowship, M.R.G. thanks the Department of
Energy (FG02-05ER15630), and J.J.B. thanks the Army Research Office for
funding. We also thank Dr. Sehoon Park, Dr. Thomas W. Lyons, and Prof.
Maurice Brookhart for stimulating conversations and initial experimental
assistance, and Dr. Marc ter Horst, for advice in preparing a
13C NMR quantification protocol.
NR 45
TC 32
Z9 32
U1 5
U2 119
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0002-7863
J9 J AM CHEM SOC
JI J. Am. Chem. Soc.
PD JAN 30
PY 2013
VL 135
IS 4
BP 1225
EP 1227
DI 10.1021/ja3110494
PG 3
WC Chemistry, Multidisciplinary
SC Chemistry
GA 083VE
UT WOS:000314492500014
PM 23305415
ER
PT J
AU Hurley, M
AF Hurley, Margaret
TI Computational Approaches to Systems Biology: Multiple Approaches to
Clostridium Acetobutylicum
SO BIOPHYSICAL JOURNAL
LA English
DT Meeting Abstract
CT 57th Annual Meeting of the Biophysical-Society
CY FEB 02-06, 2013
CL Philadelphia, PA
SP Biophys Soc
C1 [Hurley, Margaret] US Army, Res Lab, Aberdeen Proving Ground, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0006-3495
J9 BIOPHYS J
JI Biophys. J.
PD JAN 29
PY 2013
VL 104
IS 2
SU 1
BP 496A
EP 496A
PG 1
WC Biophysics
SC Biophysics
GA 105MI
UT WOS:000316074305017
ER
PT J
AU Hill, OT
Mason, TJ
Schwartz, SW
Foulis, PR
AF Hill, Owen T.
Mason, Thomas J.
Schwartz, Skai W.
Foulis, Philip R.
TI Improving prostate cancer detection in veterans through the development
of a clinical decision rule for prostate biopsy
SO BMC UROLOGY
LA English
DT Article
ID PREVENTION TRIAL; MODEL; RISK
AB Background: We sought to improve prostate cancer (PC) detection through developing a prostate biopsy clinical decision rule (PBCDR), based on an elevated PSA and laboratory biomarkers. This decision rule could be used after initial PC screening, providing the patient and clinician information to consider prior to biopsy.
Methods: This case-control study evaluated men from the Tampa, Florida, James A. Haley (JH) Veteran's Administration (VA) (N = 1,378), from January 1, 1998, through April 15, 2005. To assess the PBCDR we did all of the following: 1) Identified biomarkers that are related to PC and have the capability of improving the efficiency of PC screening; 2) Developed statistical models to determine which can best predict the probability of PC; 3) Compared each potential model to PSA alone using Receiver Operator Characteristic (ROC) curves, to evaluate for improved overall effectiveness in PC detection and reduction in (negative) biopsies; and 4) Evaluated dose-response relationships between specified lab biomarkers (surrogates for extra-prostatic disease development) and PC progression.
Results: The following biomarkers were related to PC: hemoglobin (HGB) (OR = 1.42 95% CI 1.27, 1.59); red blood cell (RBC) count (OR = 2.52 95% CI 1.67, 3.78); PSA (OR = 1.04 95% CI 1.03, 1.05); and, creatinine (OR = 1.55 95% CI 1.12, 2.15). Comparing all PC stages versus non-cancerous conditions, the ROC curve area under the curve (AUC) enlarged (increasing the probability of correctly classifying PC): PSA (alone) 0.59 (95% CI 0.55, 0.61); PBCDR model 0.68 (95% CI 0.65, 0.71), and the positive predictive value (PPV) increased: PSA 44.7%; PBCDR model 61.8%. Comparing PC (stages II, III, IV) vs. other, the ROC AUC increased: PSA (alone) 0.63 (95% CI 0.58, 0.66); PBCDR model 0.72 (95% CI 0.68, 0.75), and the PPV increased: 20.6% (PSA); PBCDR model 55.3%.
Conclusions: These results suggest evaluating certain common biomarkers in conjunction with PSA may improve PC prediction prior to biopsy. Moreover, these biomarkers may be more helpful in detecting clinically relevant PC. Follow-up studies should begin with replicating the study on different U.S. VA patients involving multiple practices.
C1 [Hill, Owen T.] USA, Injury Epidemiol Res Sect, Mil Performance Div, Inst Environm Med, Natick, MA 01760 USA.
[Mason, Thomas J.] Univ S Florida, Coll Publ Hlth, Dept Environm & Occupat Hlth, Tampa, FL 33612 USA.
[Schwartz, Skai W.] Univ S Florida, Coll Publ Hlth, Dept Epidemiol & Biostat, Tampa, FL USA.
[Foulis, Philip R.] James A Haley Vet Adm, Dept Pathol & Lab Med, Tampa, FL USA.
RP Hill, OT (reprint author), USA, Injury Epidemiol Res Sect, Mil Performance Div, Inst Environm Med, Natick, MA 01760 USA.
EM owen.hill@us.army.mil
RI Hill, Owen/E-3643-2013
NR 13
TC 2
Z9 2
U1 0
U2 3
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2490
J9 BMC UROL
JI BMC Urol.
PD JAN 29
PY 2013
VL 13
AR 6
DI 10.1186/1471-2490-13-6
PG 12
WC Urology & Nephrology
SC Urology & Nephrology
GA 089QJ
UT WOS:000314924800001
PM 23356551
ER
PT J
AU Sanchez, CJ
Mende, K
Beckius, ML
Akers, KS
Romano, DR
Wenke, JC
Murray, CK
AF Sanchez, Carlos J., Jr.
Mende, Katrin
Beckius, Miriam L.
Akers, Kevin S.
Romano, Desiree R.
Wenke, Joseph C.
Murray, Clinton K.
TI Biofilm formation by clinical isolates and the implications in chronic
infections
SO BMC INFECTIOUS DISEASES
LA English
DT Article
DE Biofilm formation; Clinical isolates; Chronic infection;
Multidrug-resistant; MRSA
ID FIELD GEL-ELECTROPHORESIS; STAPHYLOCOCCUS-AUREUS; BACTERIAL BIOFILMS;
ACINETOBACTER-BAUMANNII; CHRONIC WOUNDS; IN-VIVO; MECHANISMS;
RESISTANCE; EPIDERMIDIS; PHAGOCYTOSIS
AB Background: Biofilm formation is a major virulence factor contributing to the chronicity of infections. To date few studies have evaluated biofilm formation in infecting isolates of patients including both Gram-positive and Gram-negative multidrug-resistant (MDR) species in the context of numerous types of infectious syndromes. Herein, we investigated the biofilm forming capacity in a large collection of single patient infecting isolates and compared the relationship between biofilm formation to various strain characteristics.
Methods: The biofilm-forming capacity of 205 randomly sampled clinical isolates from patients, collected from various anatomical sites, admitted for treatment at Brooke Army Medical Center (BAMC) from 2004-2011, including methicillin-resistant/methicillin susceptible Staphylococcus aureus (MRSA/MSSA) (n=23), Acinetobacter baumannii (n=53), Pseudomonas aeruginosa (n=36), Klebsiella pneumoniae (n=54), and Escherichia coli (n=39), were evaluated for biofilm formation using the high-throughput microtiter plate assay and scanning electron microscopy (SEM). Relationships between biofilm formation to clonal type, site of isolate collection, and MDR phenotype were evaluated. Furthermore, in patients with relapsing infections, serial strains were assessed for their ability to form biofilms in vitro.
Results: Of the 205 clinical isolates tested, 126 strains (61.4%) were observed to form biofilms in vitro at levels greater than or equal to the Staphylococcus epidermidis, positive biofilm producing strain, with P. aeruginosa and S. aureus having the greatest number of biofilm producing strains. Biofilm formation was significantly associated with specific clonal types, the site of isolate collection, and strains positive for biofilm formation were more frequently observed to be MDR. In patients with relapsing infections, the majority of serial isolates recovered from these individuals were observed to be strong biofilm producers in vitro.
Conclusions: This study is the first to evaluate biofilm formation in a large collection of infecting clinical isolates representing diverse types of infections. Our results demonstrate: (1) biofilm formation is a heterogeneous property amongst clinical strains which is associated with certain clonal types, (2) biofilm forming strains are more frequently isolated from non-fluid tissues, in particular bone and soft tissues, (3) MDR pathogens are more often biofilm formers, and (4) strains from patients with persistent infections are positive for biofilm formation.
C1 [Sanchez, Carlos J., Jr.; Akers, Kevin S.; Romano, Desiree R.; Wenke, Joseph C.] USA, Dept Extrem Trauma & Regenerat Med, Inst Surg Res, Ft Sam Houston, San Antonio, TX USA.
[Mende, Katrin] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
[Mende, Katrin; Akers, Kevin S.; Murray, Clinton K.] Ft Sam Houston, Dept Med, Infect Dis Serv, San Antonio Mil Med Ctr, San Antonio, TX USA.
[Beckius, Miriam L.] Ft Sam Houston, Dept Clin Invest, San Antonio Mil, Med Ctr, San Antonio, TX USA.
RP Sanchez, CJ (reprint author), USA, Dept Extrem Trauma & Regenerat Med, Inst Surg Res, Ft Sam Houston, San Antonio, TX USA.
EM carlos.j.sanchez3@us.army.mil
RI Valle, Ruben/A-7512-2013
FU Combat Casualty Research Program, Medical Research and Materiel Command;
Armed Forces Health Surveillance Center including the Global Emerging
Infectious System; National Academy of Sciences; USUHS Infectious
Disease Clinical Research Program
FX This work was supported by intramural funding from the Combat Casualty
Research Program, Medical Research and Materiel Command to JCW, and
Armed Forces Health Surveillance Center including the Global Emerging
Infectious System to CKM. CJS is supported by a Post-doctoral Research
Associate Fellowship through the National Academy of Sciences. KM is
supported through the USUHS Infectious Disease Clinical Research
Program. The authors would like to thank Ms. Barbara Hunter at the
University of Texas Health Science Center (UTHSCSA) Institutional
Electron Microscopy core facility for her assistance with the
preparation and processing of samples for scanning electron microscopy.
Disclaimer: The views expressed herein are those of the authors and do
not reflect the official policy or position of the Department of the
Army, Department of Defense, or the US Government. The authors are
employees of the US government. This work was prepared as part of their
official duties and, as such, there is no copyright to be transferred.
NR 43
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Z9 54
U1 3
U2 76
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2334
J9 BMC INFECT DIS
JI BMC Infect. Dis.
PD JAN 29
PY 2013
VL 13
AR 47
DI 10.1186/1471-2334-13-47
PG 12
WC Infectious Diseases
SC Infectious Diseases
GA 086UZ
UT WOS:000314714800001
PM 23356488
ER
PT J
AU Morris, CJ
Wilkins, PR
May, CM
AF Morris, Christopher J.
Wilkins, Paul R.
May, Chadd M.
TI Streak spectroscopy and velocimetry of electrically exploded Ni/Al
laminates
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
ID FOILS; EXPLOSION; WIRES; COMPOSITES; EMISSION; AIR
AB We present an experimental and theoretical study of electrically exploded nickel-aluminum (Ni/Al) laminates, lithographically patterned into bow-tie bridge regions, and encapsulated with parylene. The exothermic nature of Ni/Al reactions is well-known at typical self-heating rates of 10(3)-10(6) K/s, but electrical heating allows the interrogation of phenomena at heating rates which are five to six orders of magnitude higher. The use of time-resolved streak camera emission spectroscopy revealed that Ni/Al laminates heated at these higher rates exhibited brighter emission during the first 150 ns of emission than samples composed of either Al or Ni alone, suggesting an exothermic effect which rapidly started and persisted for at least this length of time. We also measured the transduction of electrical energy into kinetic energy through velocity measurements of encapsulation layers ejected from the bridge region. An empirical model using experimental power curves and one empirical fitting parameter successfully predicted these velocities. This model agreed well with experiments from different Al and Ni samples using the same fitting parameter, but an apparent 1.2 J/mg of additional energy from the mixing of Ni and Al was necessary to accurately predict velocities from Ni/Al laminate samples. This energy quantity corresponded to a reference value for the enthalpy of mixing Ni and Al, and likely contributed to both brighter emission and higher than expected velocities observed. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4776731]
C1 [Morris, Christopher J.] USA, Res Lab, Adelphi, MD 20783 USA.
[Wilkins, Paul R.; May, Chadd M.] Lawrence Livermore Natl Lab, Livermore, CA 94550 USA.
RP Morris, CJ (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM christopher.j.morris58.civ@mail.mil
NR 42
TC 2
Z9 3
U1 0
U2 12
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0021-8979
J9 J APPL PHYS
JI J. Appl. Phys.
PD JAN 28
PY 2013
VL 113
IS 4
AR 043304
DI 10.1063/1.4776731
PG 7
WC Physics, Applied
SC Physics
GA 086XZ
UT WOS:000314724500017
ER
PT J
AU Taillon, JA
Yang, JH
Ahyi, CA
Rozen, J
Williams, JR
Feldman, LC
Zheleva, TS
Lelis, AJ
Salamanca-Riba, LG
AF Taillon, Joshua A.
Yang, Joon Hyuk
Ahyi, Claude A.
Rozen, John
Williams, John R.
Feldman, Leonard C.
Zheleva, Tsvetanka S.
Lelis, Aivars J.
Salamanca-Riba, Lourdes G.
TI Systematic structural and chemical characterization of the transition
layer at the interface of NO-annealed 4H-SiC/SiO2
metal-oxide-semiconductor field-effect transistors
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
ID ELECTRON-ENERGY-LOSS; CORE-LEVEL SHIFTS; SILICON-CARBIDE; NITRIC-OXIDE;
SPECTROSCOPY; OXIDATION; POLYTYPE; MOSFETS
AB We present a systematic characterization of the transition layer at the 4H-SiC/SiO2 interface as a function of nitric oxide (NO) post-annealing time, using high-resolution transmission electron microscopy for structural characterization and spatially resolved electron energy-loss spectroscopy for chemical analysis. We propose a systematic method for determining transition layer width by measuring the monotonic chemical shift of the Si-L-2,L-3 edge across the interface, and compare its efficacy to traditional measures from the literature, revealing the proposed method to be most reliable. A gradual shift in the Si-L-2,L-3 edge onset energy suggests mixed Si-C/Si-O bonding in the transition layer. We confirm an inverse relationship between NO-anneal time and transition layer width, which correlates with improved channel mobility, enhanced N density at the interface, and decreased interface trap density. No excess C was noted in the interfacial region. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4789924]
C1 [Taillon, Joshua A.; Yang, Joon Hyuk; Salamanca-Riba, Lourdes G.] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA.
[Ahyi, Claude A.; Williams, John R.] Auburn Univ, Dept Phys, Auburn, AL 36849 USA.
[Rozen, John; Feldman, Leonard C.] Vanderbilt Univ, Dept Phys & Astron, Nashville, TN 37235 USA.
[Zheleva, Tsvetanka S.; Lelis, Aivars J.] USA, Res Lab, Adelphi, MD 20783 USA.
RP Taillon, JA (reprint author), Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA.
EM jtaillon@umd.edu; riba@umd.edu
RI Salamanca-Riba, Lourdes/B-3785-2009
OI Salamanca-Riba, Lourdes/0000-0001-8155-6403
FU NSF as a MRSEC Shared Experimental Facility; U.S. Army Research
Laboratory [W911NF-11-2-0044, W911NF-07-2-0046]; Maryland NanoCenter;
NispLab
FX This research was performed in part at the NIST Center for Nanoscale
Science and Technology. We would like to thank Dr. Joshua Schumacher and
Mike Hernandez at NIST for their assistance in FIB TEM specimen
preparation. We acknowledge the support of the Maryland NanoCenter and
its NispLab. The NispLab is supported in part by the NSF as a MRSEC
Shared Experimental Facility. This work was supported by the U.S. Army
Research Laboratory under Contracts W911NF-11-2-0044 and
W911NF-07-2-0046.
NR 27
TC 10
Z9 11
U1 5
U2 71
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0021-8979
J9 J APPL PHYS
JI J. Appl. Phys.
PD JAN 28
PY 2013
VL 113
IS 4
AR 044517
DI 10.1063/1.4789924
PG 6
WC Physics, Applied
SC Physics
GA 086XZ
UT WOS:000314724500135
ER
PT J
AU Strawhecker, KE
Hsieh, AJ
Chantawansri, TL
Kalcioglu, ZI
Van Vliet, KJ
AF Strawhecker, Kenneth E.
Hsieh, Alex J.
Chantawansri, Tanya L.
Kalcioglu, Z. Ilke
Van Vliet, Krystyn J.
TI Influence of microstructure on micro-/nano-mechanical measurements of
select model transparent poly(urethane urea) elastomers
SO POLYMER
LA English
DT Article
DE Poly(urethane urea); AFM; Morphology
ID STRESS-STRAIN BEHAVIOR; STRUCTURE-PROPERTY RELATIONSHIPS; SEGMENTED
POLYURETHANES; POLY(PROPYLENE GLYCOL); ENERGY-DISSIPATION;
MOLECULAR-WEIGHT; SOFT SEGMENTS; MONOL CONTENT; DEFORMATION; COPOLYMERS
AB Morphology of 4,4'-dicyclohexylmethane diisocyanate poly(tetramethylene oxide) (PTMO)-diethyl toluenediamine based poly(urethane urea) (PUU) elastomers is investigated by atomic force microscopy (AFM) and compared with elastic modulus data measured from AFM-enabled indentation, dynamic nanoindentation (nanoDMA), and dynamic mechanical analysis (DMA). These measurements highlight the effect of altering the molecular weight (M-w) of PTMO, which is used as a soft segment (SS), on the microstructure. In particular, at SS M-w 2000 g/mol, a strong microphase-separated morphology is observed, whereas a phase-mixed dominated microstructure is noted in PUU with SS M-w of 1000 and 650 g/mol. These observations are also consistent with DMA tan 5 results. Furthermore, instrumented impact indentation is also utilized for elucidation of dynamic damping characteristics in these PUUs. Published by Elsevier Ltd.
C1 [Strawhecker, Kenneth E.; Hsieh, Alex J.; Chantawansri, Tanya L.] USA, Res Lab, RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA.
[Kalcioglu, Z. Ilke; Van Vliet, Krystyn J.] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA.
RP Strawhecker, KE (reprint author), USA, Res Lab, RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA.
EM kenneth.e.strawhecker.civ@mail.mil
RI Chantawansri, Tanya/N-3601-2013
FU ARL Director's Research Initiative program; U.S. Army through the
Institute for Soldier Nanotechnologies [W911NF-07-D-0004]; Army
FX KES gratefully acknowledges helpful discussions with Quinn McAllister at
the University of Delaware and with Chanmin Su, John Thornton, and Bede
Pittenger at Bruker-Nano. ICES acknowledges Dr. Aaron C. Jackson for
microtoming. AJH and TLC also acknowledge funding support from the ARL
Director's Research Initiative program. AJH, ZIK and KJVV also
acknowledge collaboration opportunity through funding support by the
U.S. Army through the Institute for Soldier Nanotechnologies, under
Contract W911NF-07-D-0004. AJH also thank Dr. Norm Rice of Triton
Systems, Inc. (Chelmsford, MA) for providing PUU materials, through an
ISN 6.2 project funded by the Army.
NR 42
TC 21
Z9 21
U1 5
U2 50
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0032-3861
J9 POLYMER
JI Polymer
PD JAN 24
PY 2013
VL 54
IS 2
BP 901
EP 908
DI 10.1016/j.polymer.2012.12.018
PG 8
WC Polymer Science
SC Polymer Science
GA 078FV
UT WOS:000314085000051
ER
PT J
AU Liao, HX
Bonsignori, M
Alam, SM
McLellan, JS
Tomaras, GD
Moody, MA
Kozink, DM
Hwang, KK
Chen, X
Tsao, CY
Liu, PH
Lu, XZ
Parks, RJ
Montefiori, DC
Ferrari, G
Pollara, J
Rao, M
Peachman, KK
Santra, S
Letvin, NL
Karasavvas, N
Yang, ZY
Dai, KF
Pancera, M
Gorman, J
Wiehe, K
Nicely, NI
Rerks-Ngarm, S
Nitayaphan, S
Kaewkungwal, J
Pitisuttithum, P
Tartaglia, J
Sinangil, F
Kim, JH
Michael, NL
Kepler, TB
Kwong, PD
Mascola, JR
Nabel, GJ
Pinter, A
Zolla-Pazner, S
Haynes, BF
AF Liao, Hua-Xin
Bonsignori, Mattia
Alam, S. Munir
McLellan, Jason S.
Tomaras, Georgia D.
Moody, M. Anthony
Kozink, Daniel M.
Hwang, Kwan-Ki
Chen, Xi
Tsao, Chun-Yen
Liu, Pinghuang
Lu, Xiaozhi
Parks, Robert J.
Montefiori, David C.
Ferrari, Guido
Pollara, Justin
Rao, Mangala
Peachman, Kristina K.
Santra, Sampa
Letvin, Norman L.
Karasavvas, Nicos
Yang, Zhi-Yong
Dai, Kaifan
Pancera, Marie
Gorman, Jason
Wiehe, Kevin
Nicely, Nathan I.
Rerks-Ngarm, Supachai
Nitayaphan, Sorachai
Kaewkungwal, Jaranit
Pitisuttithum, Punnee
Tartaglia, James
Sinangil, Faruk
Kim, Jerome H.
Michael, Nelson L.
Kepler, Thomas B.
Kwong, Peter D.
Mascola, John R.
Nabel, Gary J.
Pinter, Abraham
Zolla-Pazner, Susan
Haynes, Barton F.
TI Vaccine Induction of Antibodies against a Structurally Heterogeneous
Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1
and 2
SO IMMUNITY
LA English
DT Article
ID IMMUNODEFICIENCY-VIRUS TYPE-1; NEUTRALIZING ANTIBODIES;
MONOCLONAL-ANTIBODIES; EFFICACY TRIAL; V1/V2 DOMAIN; GP120; INFECTION;
EPITOPES; GP41; REACTIVITY
AB The RV144 HIV-1 trial of the canary pox vector (ALVAC-HIV) plus the gp120 AIDSVAX B/E vaccine demonstrated an estimated efficacy of 31%, which correlated directly with antibodies to HIV-1 envelope variable regions 1 and 2 (V1-V2). Genetic analysis of trial viruses revealed increased vaccine efficacy against viruses matching the vaccine strain at V2 residue 169. Here, we isolated four V2 monoclonal antibodies from RV144 vaccinees that recognize residue 169, neutralize laboratory-adapted HIV-1, and mediate killing of field-isolate HIV-1-infected CD4(+) T cells. Crystal structures of two of the V2 antibodies demonstrated that residue 169 can exist within divergent helical and loop conformations, which contrasted dramatically with the 13 strand conformation previously observed with a broadly neutralizing antibody PG9. Thus, RV144 vaccine-induced immune pressure appears to target a region that may be both sequence variable and structurally polymorphic. Variation may signal sites of HIV-1 envelope vulnerability, providing vaccine designers with new options.
C1 [Liao, Hua-Xin; Bonsignori, Mattia; Alam, S. Munir; Tomaras, Georgia D.; Moody, M. Anthony; Kozink, Daniel M.; Hwang, Kwan-Ki; Chen, Xi; Tsao, Chun-Yen; Liu, Pinghuang; Lu, Xiaozhi; Parks, Robert J.; Montefiori, David C.; Ferrari, Guido; Pollara, Justin; Wiehe, Kevin; Nicely, Nathan I.; Haynes, Barton F.] Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC 27710 USA.
[McLellan, Jason S.; Yang, Zhi-Yong; Dai, Kaifan; Pancera, Marie; Gorman, Jason; Kwong, Peter D.; Mascola, John R.; Nabel, Gary J.] NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA.
[Rao, Mangala; Peachman, Kristina K.; Kim, Jerome H.; Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
[Santra, Sampa; Letvin, Norman L.] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA.
[Karasavvas, Nicos; Nitayaphan, Sorachai] Armed Forces Res Inst Med Sci, US Army Med Component, Dept Retrovirol, Bangkok 10400, Thailand.
[Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi 11000, Thailand.
[Kaewkungwal, Jaranit] Mahidol Univ, Fac Trop Med, Ctr Excellence Biomed & Publ Hlth Informat BIOPHI, Bangkok 10400, Thailand.
[Tartaglia, James] Sanofi Pasteur, Swiftwater, PA 18370 USA.
[Sinangil, Faruk] Global Solut Infect Dis, San Francisco, CA 94080 USA.
[Kepler, Thomas B.] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA.
[Pinter, Abraham] Univ Med & Dent New Jersey, New Jersey Med Sch, Publ Hlth Res Inst Ctr, Newark, NJ 07103 USA.
[Zolla-Pazner, Susan] Vet Affairs New York Harbor Healthcare Syst, New York, NY 10010 USA.
[Zolla-Pazner, Susan] NYU, Sch Med, Dept Pathol, New York, NY 10016 USA.
RP Liao, HX (reprint author), Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC 27710 USA.
EM hliao@duke.edu; hayne002@mc.duke.edu
RI Ferrari, Guido/A-6088-2015; Tomaras, Georgia/J-5041-2016;
OI Kepler, Thomas/0000-0002-1383-6865; Moody, Tony/0000-0002-3890-5855
FU Bill & Melinda Gates Foundation; NIH/NIAID [AI067854, AI100645];
Department of Veterans Affairs [Y1-AI-2642-12]; U.S. Army Medical
Research and Material Command (USAMRMC) [Y1-AI-2642-12]; Henry M.
Jackson Foundation for the Advancement of Military Medicine, Inc.
[W81XWH-07-2-0067]; U.S. Department of Defense (DOD) [W81XWH-07-2-0067];
NIH; NIH grants [S10RR019145, UC6 AI058607, AI64518, P30 AI051445]
FX This study was supported by Collaboration for AIDS Vaccine Discovery
grants from Bill & Melinda Gates Foundation, by grants from NIH/NIAID
(AI067854, the Center for HIV/AIDS Vaccine Immunology, and AI100645, the
Center for HIV/AIDS Vaccine Immunology-Immunogen Discovery), by research
funds from the Department of Veterans Affairs, by an Interagency
Agreement Y1-AI-2642-12 between U.S. Army Medical Research and Material
Command (USAMRMC), by a cooperative agreement (W81XWH-07-2-0067) between
the Henry M. Jackson Foundation for the Advancement of Military
Medicine, Inc. and the U.S. Department of Defense (DOD), and by
intramural NIH support for the NIAID Vaccine Research Center. The
authors thank A. Foulger, H. Chen, M. Cooper, S. Crawford, J. Holland,
R. De, R. Scearce, L. Jeffries, Jr., A. Hogan, J. Pritchett, D. Pause,
E. Solomon, L Sutherland, J. Blinn, and K. Lloyd for expert technical
assistance in antibody and HIV-1 Env protein production; D. Marshall and
J. Whitesides for expert technical assistance in flow cytometry; and K.
Soderberg, J. Kircherr, and C. Andrews for project management. Flow
cytometry supported by NIH grants S10RR019145, UC6 AI058607, AI64518,
and P30 AI051445. The opinions herein are those of the authors and
should not be construed as official or representing the views of the
U.S. Department of Health and Human Services, National Institute for
Allergy and Infectious Diseases, the Department of Defense, the
Department of the Army, or the Department of Veteran Affairs. Materials
from the RV144 clinical trial were provided by the Ministry of Public
Health, Thailand, the Thai AIDS Vaccine Evaluation Group, and the USMHRP
through the Henry M. Jackson Foundation for the Advancement of Military
Medicine. H.-X.L., M.B., S.M.A., J.H.K., N.L.M., T.B.K., S.Z.-P., and
B.F.H. have filed partent applications on the RV144 V2 mAbs and related
antigens used in this study.
NR 45
TC 160
Z9 161
U1 4
U2 46
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1074-7613
J9 IMMUNITY
JI Immunity
PD JAN 24
PY 2013
VL 38
IS 1
BP 176
EP 186
DI 10.1016/j.immuni.2012.11.011
PG 11
WC Immunology
SC Immunology
GA 079TQ
UT WOS:000314195500019
PM 23313589
ER
PT J
AU Otsyula, N
Angov, E
Bergmann-Leitner, E
Koech, M
Khan, F
Bennett, J
Otieno, L
Cummings, J
Andagalu, B
Tosh, D
Waitumbi, J
Richie, N
Shi, M
Miller, L
Otieno, W
Otieno, GA
Ware, L
House, B
Godeaux, O
Dubois, MC
Ogutu, B
Ballou, WR
Soisson, L
Diggs, C
Cohen, J
Polhemus, M
Heppner, DG
Ockenhouse, CF
Spring, MD
AF Otsyula, Nekoye
Angov, Evelina
Bergmann-Leitner, Elke
Koech, Margaret
Khan, Farhat
Bennett, Jason
Otieno, Lucas
Cummings, James
Andagalu, Ben
Tosh, Donna
Waitumbi, John
Richie, Nancy
Shi, Meng
Miller, Lori
Otieno, Walter
Otieno, Godfrey Allan
Ware, Lisa
House, Brent
Godeaux, Olivier
Dubois, Marie-Claude
Ogutu, Bernhards
Ballou, W. Ripley
Soisson, Lorraine
Diggs, Carter
Cohen, Joe
Polhemus, Mark
Heppner, D. Gray, Jr.
Ockenhouse, Christian F.
Spring, Michele D.
TI Results from tandem Phase 1 studies evaluating the safety,
reactogenicity and immunogenicity of the vaccine candidate antigen
Plasmodium falciparum FVO merozoite surface protein-1 (MSP1(42))
administered intramuscularly with adjuvant system AS01
SO MALARIA JOURNAL
LA English
DT Article
DE Malaria; Vaccine; Merozoite surface protein-1; Plasmodium
ID PROTECTS AOTUS MONKEYS; MALARIA-NAIVE ADULTS; BLOOD-STAGE VACCINE;
C-TERMINAL FRAGMENT; INHIBITORY ANTIBODIES; TRIAL; CHALLENGE; GROWTH;
RTS,S/AS02A; PARASITES
AB Background: The development of an asexual blood stage vaccine against Plasmodium falciparum malaria based on the major merozoite surface protein-1 (MSP1) antigen is founded on the protective efficacy observed in preclinical studies and induction of invasion and growth inhibitory antibody responses. The 42 kDa C-terminus of MSP1 has been developed as the recombinant protein vaccine antigen, and the 3D7 allotype, formulated with the Adjuvant System AS02A, has been evaluated extensively in human clinical trials. In preclinical rabbit studies, the FVO allele of MSP1(42) has been shown to have improved immunogenicity over the 3D7 allele, in terms of antibody titres as well as growth inhibitory activity of antibodies against both the heterologous 3D7 and homologous FVO parasites.
Methods: Two Phase 1 clinical studies were conducted to examine the safety, reactogenicity and immunogenicity of the FVO allele of MSP1(42) in the adjuvant system AS01 administered intramuscularly at 0-, 1-, and 2-months: one in the USA and, after evaluation of safety data results, one in Western Kenya. The US study was an open-label, dose escalation study of 10 and 50 mu g doses of MSP1(42) in 26 adults, while the Kenya study, evaluating 30 volunteers, was a double-blind, randomized study of only the 50 mu g dose with a rabies vaccine comparator.
Results: In these studies it was demonstrated that this vaccine formulation has an acceptable safety profile and is immunogenic in malaria-naive and malaria-experienced populations. High titres of anti-MSP1 antibodies were induced in both study populations, although there was a limited number of volunteers whose serum demonstrated significant inhibition of blood-stage parasites as measured by growth inhibition assay. In the US volunteers, the antibodies generated exhibited better cross-reactivity to heterologous MSP1 alleles than a MSP1-based vaccine (3D7 allele) previously tested at both study sites.
Conclusions: Given that the primary effector mechanism for blood stage vaccine targets is humoral, the antibody responses demonstrated to this vaccine candidate, both quantitative (total antibody titres) and qualitative (functional antibodies inhibiting parasite growth) warrant further consideration of its application in endemic settings.
C1 [Otsyula, Nekoye; Koech, Margaret; Otieno, Lucas; Andagalu, Ben; Waitumbi, John; Otieno, Walter; Otieno, Godfrey Allan; Ogutu, Bernhards] Kenya Govt Med Res Ctr, Walter Reed Project, Kisumu, Kenya.
[Angov, Evelina; Bergmann-Leitner, Elke; Khan, Farhat; Bennett, Jason; Cummings, James; Tosh, Donna; Richie, Nancy; Shi, Meng; Miller, Lori; Ware, Lisa; House, Brent; Polhemus, Mark; Heppner, D. Gray, Jr.; Ockenhouse, Christian F.; Spring, Michele D.] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD USA.
[Godeaux, Olivier; Dubois, Marie-Claude; Ballou, W. Ripley; Cohen, Joe] GlaxoSmithKline Biol, Rixensart, Belgium.
[Soisson, Lorraine; Diggs, Carter] US Agcy Int Dev, Washington, DC 20523 USA.
RP Ockenhouse, CF (reprint author), Walter Reed Army Inst Res, Malaria Vaccine Branch, 2460 Linden Lane,Bldg 503, Silver Spring, MD USA.
EM christian.f.ockenhouse@us.army.mil
RI Bennett, Jason/B-3547-2011; Bergmann-Leitner, Elke/B-3548-2011
OI Bergmann-Leitner, Elke/0000-0002-8571-8956
FU Office of the Surgeon General, US Army; US Agency for International
Development (USAID); GlaxoSmithKline Biologicals (GSK); US Army Medical
and Materiel Research Command (USAMRMC)
FX MCD, OG, JC and WRB are employees of GlaxoSmithKline Biologicals s.a.
(GSK). They own shares and options to shares in GSK. In addition JC and
WRB are listed as inventors of patented malaria vaccines, but do not
hold a patent for a malaria vaccine. Specifically EA and JC are listed
as inventors on patent for this MSP142FVO antigen. The Study
Sponsor was the Office of the Surgeon General, US Army. This study was
funded by the US Agency for International Development (USAID), with
partial support from GlaxoSmithKline Biologicals (GSK) and the US Army
Medical and Materiel Research Command (USAMRMC). There are no other
competing interests.
NR 39
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U1 0
U2 9
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD JAN 23
PY 2013
VL 12
AR 29
DI 10.1186/1475-2875-12-29
PG 13
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 118YC
UT WOS:000317062200001
PM 23342996
ER
PT J
AU Chen, L
Li, YH
Fu, YB
Peng, J
Mo, MH
Stamatakos, M
Teal, CB
Brem, RF
Stojadinovic, A
Grinkemeyer, M
McCaffrey, TA
Man, YG
Fu, SW
AF Chen, Liang
Li, Youhuai
Fu, Yebo
Peng, Jin
Mo, Meng-Hsuan
Stamatakos, Michael
Teal, Christine B.
Brem, Rachel F.
Stojadinovic, Alexander
Grinkemeyer, Michael
McCaffrey, Timothy A.
Man, Yan-Gao
Fu, Sidney W.
TI Role of Deregulated microRNAs in Breast Cancer Progression Using FFPE
Tissue
SO PLOS ONE
LA English
DT Article
ID EPITHELIAL-MESENCHYMAL TRANSITION; MYOEPITHELIAL CELL LAYER; CONSERVED
RNA SEQUENCE; GENE-EXPRESSION; TUMOR INVASION; MIR-200 FAMILY;
REPRESSORS ZEB1; METASTASIS; TARGETS; SAMPLES
AB MicroRNAs (miRNAs) contribute to cancer initiation and progression by silencing the expression of their target genes, causing either mRNA molecule degradation or translational inhibition. Intraductal epithelial proliferations of the breast are histologically and clinically classified into normal, atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC). To better understand the progression of ductal breast cancer development, we attempt to identify deregulated miRNAs in this process using Formalin-Fixed, Paraffin-Embedded (FFPE) tissues from breast cancer patients. Following tissue microdissection, we obtained 8 normal, 4 ADH, 6 DCIS and 7 IDC samples, which were subject to RNA isolation and miRNA expression profiling analysis. We found that miR-21, miR-200b/c, miR-141, and miR-183 were consistently up-regulated in ADH, DCIS and IDC compared to normal, while miR-557 was uniquely down-regulated in DCIS. Interestingly, the most significant miRNA deregulations occurred during the transition from normal to ADH. However, the data did not reveal a step-wise miRNA alteration among discrete steps along tumor progression, which is in accordance with previous reports of mRNA profiling of different stages of breast cancer. Furthermore, the expression of MSH2 and SMAD7, two important molecules involving TGF-beta pathway, was restored following miR-21 knockdown in both MCF-7 and Hs578T breast cancer cells. In this study, we have not only identified a number of potential candidate miRNAs for breast cancer, but also found that deregulation of miRNA expression during breast tumorigenesis might be an early event since it occurred significantly during normal to ADH transition. Consequently, we have demonstrated the feasibility of miRNA expression profiling analysis using archived FFPE tissues, typically with rich clinical information, as a means of miRNA biomarker discovery.
C1 [Chen, Liang; Fu, Yebo; Peng, Jin; Mo, Meng-Hsuan; McCaffrey, Timothy A.; Fu, Sidney W.] George Washington Univ, Sch Med & Hlth Sci, Dept Microbiol Immunol & Trop Med, Div Genom Med,Dept Med, Washington, DC 20052 USA.
[Li, Youhuai] Baoji Cent Hosp, Dept Surg, Breast Canc Div, Baoji, Shaanxi, Peoples R China.
[Stamatakos, Michael] George Washington Univ, Sch Med & Hlth Sci, Dept Pathol, Washington, DC 20052 USA.
[Teal, Christine B.] George Washington Univ, Sch Med & Hlth Sci, Dept Surg, Washington, DC 20052 USA.
[Brem, Rachel F.] George Washington Univ, Sch Med & Hlth Sci, Dept Radiol, Washington, DC 20052 USA.
[Stojadinovic, Alexander; Grinkemeyer, Michael] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
[Man, Yan-Gao] Henry Jackson Fdn, Diagnost & Translat Res Ctr, Gaithersburg, MD USA.
RP Fu, SW (reprint author), George Washington Univ, Sch Med & Hlth Sci, Dept Microbiol Immunol & Trop Med, Div Genom Med,Dept Med, Washington, DC 20052 USA.
EM sfu@gwu.edu
OI Chen, Liang/0000-0002-3605-8883
FU Wendy Will Case Foundation; Hao Foundation; NCI/NIH [R21CA159103]
FX This work was supported by the Wendy Will Case Foundation, the Hao
Foundation and the NCI/NIH awards (R21CA159103) to SWF. The funders had
no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript.
NR 47
TC 41
Z9 43
U1 1
U2 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 23
PY 2013
VL 8
IS 1
AR e54213
DI 10.1371/journal.pone.0054213
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 077IQ
UT WOS:000314021500041
PM 23372687
ER
PT J
AU Lambrechts, L
Quillery, E
Noel, V
Richardson, JH
Jarman, RG
Scott, TW
Chevillon, C
AF Lambrechts, Louis
Quillery, Elsa
Noel, Valerie
Richardson, Jason H.
Jarman, Richard G.
Scott, Thomas W.
Chevillon, Christine
TI Specificity of resistance to dengue virus isolates is associated with
genotypes of the mosquito antiviral gene Dicer-2
SO PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
LA English
DT Article
DE Aedes aegypti; dengue virus; genotype-by-genotype interaction; Dicer-2;
RNAi
ID ALLELE FREQUENCY DATA; AEDES-AEGYPTI; DROSOPHILA-MELANOGASTER; RNA
INTERFERENCE; POLYMORPHISM DATA; MALARIA PARASITE; COMPUTER-PROGRAM;
HOST-DEFENSE; EVOLUTION; IMMUNITY
AB In contrast to the prevailing view that invertebrate immunity relies on broad-spectrum recognition and effector mechanisms, intrinsic genetic compatibility between invertebrate hosts and their pathogens is often highly specific in nature. Solving this puzzle requires a better understanding of the molecular basis underlying observed patterns of invertebrate host-pathogen genetic specificity, broadly referred to as genotype-by-genotype interactions. Here, we identify an invertebrate immune gene in which natural polymorphism is associated with isolate-specific resistance to an RNA virus. Dicer-2 (dcr2) encodes a key protein upstream of the RNA interference (RNAi) pathway, a major antiviral component of innate immunity in invertebrates. We surveyed allelic polymorphism at the dcr2 locus in a wild-type outbred population and in three derived isofemale families of the mosquito Aedes aegypti that were experimentally exposed to several, genetically distinct isolates of dengue virus. We found that dcr2 genotype was associated with resistance to dengue virus in a virus isolate-specific manner. By contrast, no such association was found for genotypes at two control loci flanking dcr2, making it likely that dcr2 contains the yet-unidentified causal polymorphism(s). This result supports the idea that host-pathogen compatibility in this system depends, in part, on a genotype-by-genotype interaction between dcr2 and the viral genome, and points to the RNAi pathway as a potentially important determinant of intrinsic insect-virus genetic specificity.
C1 [Lambrechts, Louis] Inst Pasteur, CNRS, Insects & Infect Dis URA 3012, F-75724 Paris 15, France.
[Quillery, Elsa; Noel, Valerie; Chevillon, Christine] Univ Montpellier 2, Univ Montpellier 1, IRD, MIVEGEC Lab,UMR 5290,CNRS, F-34394 Montpellier 5, France.
[Quillery, Elsa; Noel, Valerie; Chevillon, Christine] IRD, UR 224, F-34394 Montpellier 5, France.
[Richardson, Jason H.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA.
[Jarman, Richard G.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA.
[Scott, Thomas W.] Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA.
RP Lambrechts, L (reprint author), Inst Pasteur, CNRS, Insects & Infect Dis URA 3012, 25 Rue Docteur Roux, F-75724 Paris 15, France.
EM louis.lambrechts@pasteur.fr
RI Richardson, Jason/A-9441-2011; Lambrechts, Louis/A-2057-2010; Chevillon,
Christine/L-4645-2013
OI Lambrechts, Louis/0000-0001-5958-2138; Chevillon,
Christine/0000-0002-1262-5839
FU European Commission [MOIF-CT-2006-039855]; French Agence Nationale de la
Recherche [ANR-09-RPDOC-007-01]; French governmental agency Centre
National de la Recherche Scientifique (CNRS); French governmental agency
Institut de Recherche pour le Developpement; CNRS
FX The authors thank Apolline Pichon for help with mosquito genotyping and
three anonymous reviewers for helpful comments. L. L. was supported by
Marie Curie Outgoing International Fellowship MOIF-CT-2006-039855 from
the Sixth Framework Programme of the European Commission and
ANR-09-RPDOC-007-01 from the French Agence Nationale de la Recherche. C.
C. was funded by the French governmental agencies Centre National de la
Recherche Scientifique (CNRS) and Institut de Recherche pour le
Developpement. This work received partial support from the CNRS
programme 'Maladies Infectieuses Emergentes'. The opinions or assertions
contained herein are the private views of the authors and are not to be
construed as reflecting the official views of the United States Army,
Royal Thai Army or the United States Department of Defense.
NR 51
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U1 1
U2 48
PU ROYAL SOC
PI LONDON
PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND
SN 0962-8452
J9 P ROY SOC B-BIOL SCI
JI Proc. R. Soc. B-Biol. Sci.
PD JAN 22
PY 2013
VL 280
IS 1751
AR 20122437
DI 10.1098/rspb.2012.2437
PG 9
WC Biology; Ecology; Evolutionary Biology
SC Life Sciences & Biomedicine - Other Topics; Environmental Sciences &
Ecology; Evolutionary Biology
GA 049PC
UT WOS:000311994600011
PM 23193131
ER
PT J
AU Milner, JL
Abu-Farha, F
Bunget, C
Kurfess, T
Hammond, VH
AF Milner, Justin L.
Abu-Farha, Fadi
Bunget, Cristina
Kurfess, Thomas
Hammond, Vincent H.
TI Grain refinement and mechanical properties of CP-Ti processed by warm
accumulative roll bonding
SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES
MICROSTRUCTURE AND PROCESSING
LA English
DT Article
DE Accumulative roll bonding; Severe plastic deformation; CP Titanium;
Grain refinement; Electron microscopy; Mechanical characterization
ID SEVERE PLASTIC-DEFORMATION; ROOM-TEMPERATURE; ARB PROCESS; BIOMEDICAL
APPLICATIONS; ALUMINUM-ALLOY; PURE TITANIUM; SHEAR STRAIN;
MICROSTRUCTURE; ECAP; SPD
AB Accumulative roll bonding (ARB), a severe plastic deformation technique, was used in this study to process commercially pure titanium (CP-Ti) at 450 degrees C. Sheet samples were processed by seven consecutive ARB cycles, with an overall equivalent strain of 5.6. Mechanical characterization and microstructural examination were carried out on the processed material to track their changes and relationships with regard to one another. Electron microscopy, TEM in particular, revealed significant grain refinement in the material, with submicron microstructure achieved even after one cycle of warm processing. Further processing was shown to progressively fragment the highly elongated grains, ultimately producing a predominantly-equiaxed ultrafine grain structure with an average grain size of similar to 100 nm. Tensile strength and microhardness of the material increased with the number of ARB cycles; the strength-grain size relationship followed the Hall-Petch equation. The overall grain refinement and strengthening levels observed here are close to those reported in the literature for ARB processing of CP-Ti at ambient temperatures. This demonstrates the ability of warm ARE can be as effective as cold ARB, while offering several advantages for industrial utilization. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Milner, Justin L.; Abu-Farha, Fadi; Bunget, Cristina] Clemson Univ, Dept Automot Engn, Greenville, SC 29607 USA.
[Kurfess, Thomas] Georgia Inst Technol, Dept Mech Engn, Atlanta, GA 30332 USA.
[Hammond, Vincent H.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Abu-Farha, F (reprint author), Clemson Univ, Dept Automot Engn, Greenville, SC 29607 USA.
EM FADI@clemson.edu
FU Army Research Laboratory [W911NF-10-1-0413]
FX The authors are grateful to RTI International Metals for providing
access to the rolling mill using which all the ARB runs reported in this
work were performed. The authors are also grateful to JTEKT-Greenville
Technology Center for helping with tensile testing, specimen
preparation, optical microscopy, and microhardness measurements. All the
electron microscopy work was performed at the Advanced Material Research
Lab (AMRL) of Clemson University; the efforts of their team are greatly
appreciated. This work was supported in part by the Army Research
Laboratory under grant number W911NF-10-1-0413.
NR 35
TC 23
Z9 24
U1 5
U2 32
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0921-5093
EI 1873-4936
J9 MAT SCI ENG A-STRUCT
JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process.
PD JAN 20
PY 2013
VL 561
BP 109
EP 117
DI 10.1016/j.msea.2012.10.081
PG 9
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Metallurgy & Metallurgical Engineering
SC Science & Technology - Other Topics; Materials Science; Metallurgy &
Metallurgical Engineering
GA 236YP
UT WOS:000325835700014
ER
PT J
AU Lee, JS
Grubaugh, ND
Kondig, JP
Turell, MJ
Kim, HC
Klein, TA
O'Guinn, ML
AF Lee, John S.
Grubaugh, Nathan D.
Kondig, John P.
Turell, Michael J.
Kim, Heung-Chul
Klein, Terry A.
O'Guinn, Monica L.
TI Isolation and genomic characterization of Chaoyang virus strain ROK144
from Aedes vexans nipponii from the Republic of Korea
SO VIROLOGY
LA English
DT Article
DE Arthropod-specific flavivirus; Mosquito flavivirus; Vector surveillance;
Arbovirus
ID NATURAL MOSQUITO POPULATION; AMAZON BASIN REGION; FUSING AGENT VIRUS;
INSECT FLAVIVIRUS; CULEX; TRANSMISSION; PERU
AB During June 2003, mosquito surveillance was conducted at a US Army installation and a US Military training site 2 km south of the demilitarized zone, Republic of Korea. Mosquitoes were collected using Mosquito Magnets (TM), sorted to species, and assayed for the presence of arboviruses. From the 3,149 mosquitoes that were sorted into 126 pools, one Aedes vexans nipponii pool (out of 73 pools) tested positive for flavivirus RNA by reverse transcription-PCR. After isolation from C6/36 cell culture supernatant, the viral genome was sequenced and found to be 98.9% related to Chaoyang virus, a potential arthropod-specific flavivirus. This report details the first identification of Chaoyang virus in the Republic of Korea and highlights its relationship to other flaviviruses. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Grubaugh, Nathan D.; Turell, Michael J.] USA, Div Virol, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Kondig, John P.] USA, Diagnost Syst Div, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Kim, Heung-Chul] 168th Multifunct Med Battal, Med Detachment 5, Seoul, South Korea.
[Klein, Terry A.] 65th Med Brigade USAMEDDAC Korea, Force Hlth Protect & Prevent Med, Seoul, South Korea.
[Lee, John S.; O'Guinn, Monica L.] Mil Infect Dis Res Program, Ft Detrick, MD 21702 USA.
RP Lee, JS (reprint author), USA, MIDRP, Res & Mat Command, Bldg 722,504 Scott Ave, Frederick, MD 21702 USA.
EM john.s.lee@amedd.army.mil
RI Valle, Ruben/A-7512-2013
FU United States Army Medical Research Institute of Infectious Diseases,
Fort Detrick, MD; 65th Medical Brigade, Yongsan, Seoul, ROK; Armed
Forces Health Surveillance Center-Global Emerging Infections
Surveillance and Response System, Silver Spring, MD; [U0176_09_RD]
FX This work was supported through the joint partnership between the United
States Army Medical Research Institute of Infectious Diseases, Fort
Detrick, MD; 65th Medical Brigade, Yongsan, Seoul, ROK; and the Armed
Forces Health Surveillance Center-Global Emerging Infections
Surveillance and Response System, Silver Spring, MD, and was funded in
part by the Military Infectious Disease Research Program project #
U0176_09_RD. The mention of trade names or commercial products does not
constitute endorsement or recommendation for use by the Department of
the Army or the Department of Defense. The opinions and assertions
contained herein are those of the authors and are not to be construed as
official or reflecting the views of the Department of the Army or the
Department of Defense.
NR 24
TC 18
Z9 18
U1 0
U2 9
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0042-6822
J9 VIROLOGY
JI Virology
PD JAN 20
PY 2013
VL 435
IS 2
BP 220
EP 224
DI 10.1016/j.viro1.2012.10.020
PG 5
WC Virology
SC Virology
GA 069TE
UT WOS:000313459200004
PM 23127596
ER
PT J
AU Knapik, JJ
Graham, B
Cobbs, J
Thompson, D
Steelman, R
Jones, BH
AF Knapik, Joseph J.
Graham, Bria
Cobbs, Jacketta
Thompson, Diane
Steelman, Ryan
Jones, Bruce H.
TI A prospective investigation of injury incidence and injury risk factors
among army recruits in military police training
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Article
DE Age; Smoking; Exercise; Physical activity; Prior injury; Menstrual
cycle; Pregnancy
ID EXERCISE-RELATED INJURIES; HAMSTRING STRAIN INJURY; SMOKELESS TOBACCO
USE; UNITED-STATES-ARMY; CIGARETTE-SMOKING; STRESS-FRACTURES;
PHYSICAL-ACTIVITY; YOUNG MEN; MUSCULOSKELETAL INJURIES; REDUCTION
EFFECTIVENESS
AB Background: United States Army military police (MP) training is a 19-week course designed to introduce new recruits to basic soldiering skills, Army values and lifestyle, and law enforcement skills and knowledge. The present investigation examined injury rates and injury risk factors in MP training.
Methods: At the start of training, 1,838 male and 553 female MP recruits were administered a questionnaire containing items on date of birth, height, weight, tobacco use, prior physical activity, injury history, and menstrual history. Injuries during training were obtained from electronic medical records and the training units provided data on student graduation and attrition.
Results: Successfully graduating from the course were 94.3% of the men and 83.7% of the women. Experiencing at least one injury during training were 34.2% of the men and 66.7% of the women (risk ratio (women/men) = 1.95, 95% confidence interval = 1.79-2.13). Recruits were at higher injury risk if they reported that they were older, had smoked in the past, or had performed less frequent exercise or sports prior to MP training. Men were at higher injury risk if they reported a prior injury and women were at higher risk if they reported missing at least six menstrual cycles in the last year or had previously been pregnant.
Conclusion: The present investigation was the first to identify injury rates and identify specific factors increasing injury risk during MP training.
C1 [Knapik, Joseph J.; Graham, Bria; Steelman, Ryan; Jones, Bruce H.] USA, Inst Publ Hlth, Portfolio Epidemiol & Dis Surveillance, ATTN MCHB IP DI, Aberdeen Proving Ground, MD 21010 USA.
[Cobbs, Jacketta] Med Univ S Carolina, Dept Obstet & Gynecol, Charleston, SC 29425 USA.
[Thompson, Diane] AIDS Resource Ctr Wisconsin, Milwaukee, WI 53203 USA.
RP Knapik, JJ (reprint author), USA, Inst Publ Hlth, Portfolio Epidemiol & Dis Surveillance, ATTN MCHB IP DI, 1570 Stark Rd, Aberdeen Proving Ground, MD 21010 USA.
EM joseph.knapik@us.army.mil
FU appointment to the Knowledge Preservation Program at the U.S. Army
Public Health Command (USAPHC)
FX We would like to thank individuals who assisted with the organization of
this investigation including Ms Martha Collins, LTC Dean Kucera, MSG
James Clayton, LTC Glasscock, MAJ Adam Smith, SSG Jamal Williams, Ms
Shelley Delamarter, Ms Portia Ellis and Mr Brian Raymond. This research
was supported in part by an appointment to the Knowledge Preservation
Program at the U.S. Army Public Health Command (USAPHC) administered by
the Oak Ridge Institute for Science and Education through an interagency
agreement between the U.S. Department of Energy and USAPHC. The views,
opinions, and/or findings contained in this report are those of the
authors and should not be construed as official Department of the Army
position, policy, or decision, unless so designated by other official
documentation. Approved for public release; distribution is unlimited.
NR 105
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U1 0
U2 15
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD JAN 17
PY 2013
VL 14
AR 32
DI 10.1186/1471-2474-14-32
PG 11
WC Orthopedics; Rheumatology
SC Orthopedics; Rheumatology
GA 124QD
UT WOS:000317479400001
PM 23327563
ER
PT J
AU Elizaga, ML
Vasan, S
Marovich, MA
Sato, AH
Lawrence, DN
Chaitman, BR
Frey, SE
Keefer, MC
AF Elizaga, Marnie L.
Vasan, Sandhya
Marovich, Mary A.
Sato, Alicia H.
Lawrence, Dale N.
Chaitman, Bernard R.
Frey, Sharon E.
Keefer, Michael C.
CA MVA Cardiac Safety Working Grp
TI Prospective Surveillance for Cardiac Adverse Events in Healthy Adults
Receiving Modified Vaccinia Ankara Vaccines: A Systematic Review
SO PLOS ONE
LA English
DT Article
ID JANUARY-OCTOBER 2003; T-CELL RESPONSES; PHASE-I TRIAL; SMALLPOX
VACCINATION; UNITED-STATES; DRYVAX(R) CHALLENGE; CANDIDATE VACCINE;
NYVAC-C; VIRUS; SAFETY
AB Background: Vaccinia-associated myo/pericarditis was observed during the US smallpox vaccination (DryVax) campaign initiated in 2002. A highly-attenuated vaccinia strain, modified vaccinia Ankara (MVA) has been evaluated in clinical trials as a safer alternative to DryVax and as a vector for recombinant vaccines. Due to the lack of prospectively collected cardiac safety data, the US Food and Drug Administration required cardiac screening and surveillance in all clinical trials of MVA since 2004. Here, we report cardiac safety surveillance from 6 phase I trials of MVA vaccines.
Methods: Four clinical research organizations contributed cardiac safety data using common surveillance methods in trials administering MVA or recombinant MVA vaccines to healthy participants. 'Routine cardiac investigations' (ECGs and cardiac enzymes obtained 2 weeks after injections of MVA or MVA-HIV recombinants, or placebo-controls), and 'Symptom-driven cardiac investigations' are reported. The outcome measure is the number of participants who met the CDC-case definition for vaccinia-related myo/pericarditis or who experienced cardiac adverse events from an MVA vaccine.
Results: Four hundred twenty-five study participants had post-vaccination safety data analyzed, 382 received at least one MVA-containing vaccine and 43 received placebo; 717 routine ECGs and 930 cardiac troponin assays were performed. Forty-five MVA recipients (12%) had additional cardiac testing performed; 22 for cardiac symptoms, 19 for ECG/laboratory changes, and 4 for cardiac symptoms with an ECG/laboratory change. No participant had evidence of symptomatic or asymptomatic myo/pericarditis meeting the CDC-case definition and judged to be related to an MVA vaccine.
Conclusions: Prospective surveillance of MVA recipients for myo/pericarditis did not detect cardiac adverse reactions in 382 study participants.
C1 [Elizaga, Marnie L.] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USA.
[Vasan, Sandhya] Aaron Diamond AIDS Res Ctr, New York, NY USA.
[Marovich, Mary A.] Walter Reed Army Inst Res, US Mil HIV Res Program, Rockville, MD USA.
[Sato, Alicia H.] Fred Hutchinson Canc Res Ctr, SCHARP, Seattle, WA 98104 USA.
[Lawrence, Dale N.] NIAID, Div Aids, NIH, Bethesda, MD 20892 USA.
[Chaitman, Bernard R.] St Louis Univ, Sch Med, Div Cardiol, St Louis, MO USA.
[Frey, Sharon E.] St Louis Univ, Sch Med, Clin Res Div Infect Dis Allergy & Immunol, St Louis, MO USA.
[Keefer, Michael C.] Univ Rochester, Sch Med & Dent, Rochester, NY 14627 USA.
RP Keefer, MC (reprint author), Univ Rochester, Sch Med & Dent, Rochester, NY 14627 USA.
EM Michael_Keefer@URMC.Rochester.edu
FU National Institutes of Health [N01 AI25464, UM1 AI069511, UM1 AI068614,
UM1 AI046747, UM1 AIO68614, UM1 AI068635]
FX This work was supported by the National Institutes of Health grant
numbers N01 AI25464, UM1 AI069511, UM1 AI068614, UM1 AI046747, UM1
AIO68614, UM1 AI068635. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
NR 39
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U1 0
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 17
PY 2013
VL 8
IS 1
AR e54407
DI 10.1371/journal.pone.0054407
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 073JI
UT WOS:000313738900066
PM 23349878
ER
PT J
AU Zolla-Pazner, S
deCamp, AC
Cardozo, T
Karasavvas, N
Gottardo, R
Williams, C
Morris, DE
Tomaras, G
Rao, M
Billings, E
Berman, P
Shen, XY
Andrews, C
O'Connell, RJ
Ngauy, V
Nitayaphan, S
de Souza, M
Korber, B
Koup, R
Bailer, RT
Mascola, JR
Pinter, A
Montefiori, D
Haynes, BF
Robb, ML
Rerks-Ngarm, S
Michael, NL
Gilbert, PB
Kim, JH
AF Zolla-Pazner, Susan
deCamp, Allan C.
Cardozo, Timothy
Karasavvas, Nicos
Gottardo, Raphael
Williams, Constance
Morris, Daryl E.
Tomaras, Georgia
Rao, Mangala
Billings, Erik
Berman, Phillip
Shen, Xiaoying
Andrews, Charla
O'Connell, Robert J.
Ngauy, Viseth
Nitayaphan, Sorachai
de Souza, Mark
Korber, Bette
Koup, Richard
Bailer, Robert T.
Mascola, John R.
Pinter, Abraham
Montefiori, David
Haynes, Barton F.
Robb, Merlin L.
Rerks-Ngarm, Supachai
Michael, Nelson L.
Gilbert, Peter B.
Kim, Jerome H.
TI Analysis of V2 Antibody Responses Induced in Vaccinees in the
ALVAC/AIDSVAX HIV-1 Vaccine Efficacy Trial
SO PLOS ONE
LA English
DT Article
ID IMMUNODEFICIENCY-VIRUS TYPE-1; QUATERNARY NEUTRALIZING EPITOPE; V1/V2
DOMAIN; HIV-1-INFECTED INDIVIDUALS; MONOCLONAL-ANTIBODIES; CHEMOKINE
RECEPTOR; GP120; POTENT; INFECTION; REGIONS
AB The RV144 clinical trial of a prime/boost immunizing regimen using recombinant canary pox (ALVAC-HIV) and two gp120 proteins (AIDSVAX B and E) was previously shown to have a 31.2% efficacy rate. Plasma specimens from vaccine and placebo recipients were used in an extensive set of assays to identify correlates of HIV-1 infection risk. Of six primary variables that were studied, only one displayed a significant inverse correlation with risk of infection: the antibody (Ab) response to a fusion protein containing the V1 and V2 regions of gp120 (gp70-V1V2). This finding prompted a thorough examination of the results generated with the complete panel of 13 assays measuring various V2 Abs in the stored plasma used in the initial pilot studies and those used in the subsequent case-control study. The studies revealed that the ALVAC-HIV/AIDSVAX vaccine induced V2-specific Abs that cross-react with multiple HIV-1 subgroups and recognize both conformational and linear epitopes. The conformational epitope was present on gp70-V1V2, while the predominant linear V2 epitope mapped to residues 165-178, immediately N-terminal to the putative alpha 4 beta 7 binding motif in the mid-loop region of V2. Odds ratios (ORs) were calculated to compare the risk of infection with data from 12 V2 assays, and in 11 of these, the ORs were <= 1, reaching statistical significance for two of the variables: Ab responses to gp70-V1V2 and to overlapping V2 linear peptides. It remains to be determined whether anti-V2 Ab responses were directly responsible for the reduced infection rate in RV144 and whether anti-V2 Abs will prove to be important with other candidate HIV vaccines that show efficacy, however, the results support continued dissection of Ab responses to the V2 region which may illuminate mechanisms of protection from HIV-1 infection and may facilitate the development of an effective HIV-1 vaccine.
C1 [Zolla-Pazner, Susan] Vet Affairs Med Ctr, Res Serv, New York, NY USA.
[Zolla-Pazner, Susan; Cardozo, Timothy; Williams, Constance] NYU, Sch Med, Dept Pathol, New York, NY USA.
[Zolla-Pazner, Susan; Cardozo, Timothy; Williams, Constance] NYU, Sch Med, Dept Biochem & Mol Pharmacol, New York, NY USA.
[deCamp, Allan C.; Gottardo, Raphael; Morris, Daryl E.; Gilbert, Peter B.] Fred Hutchinson Canc Res Ctr, Stat Ctr HIV AIDS Res & Prevent SCHARP, Vaccine & Infect Dis Div, Seattle, WA 98104 USA.
[Karasavvas, Nicos; Ngauy, Viseth; Nitayaphan, Sorachai; de Souza, Mark] USA, Mat Command, Armed Forces Res Inst Med Sci, Bangkok, Thailand.
[Tomaras, Georgia; Shen, Xiaoying; Montefiori, David; Haynes, Barton F.] Duke Univ, Sch Med, Human Vaccine Inst, Durham, NC USA.
[Rao, Mangala; Billings, Erik; Andrews, Charla; O'Connell, Robert J.; Robb, Merlin L.; Michael, Nelson L.; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Berman, Phillip] Univ Calif Santa Cruz, Dept Biomol Engn, Santa Cruz, CA 95064 USA.
[Korber, Bette] Los Alamos Natl Lab, Theoret Biol & Biophys Grp, Los Alamos, NM USA.
[Koup, Richard; Bailer, Robert T.; Mascola, John R.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
[Pinter, Abraham] Univ Med & Dent New Jersey, Publ Hlth Res Inst, Newark, NJ 07103 USA.
[Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand.
[Gilbert, Peter B.] Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
RP Zolla-Pazner, S (reprint author), Vet Affairs Med Ctr, Res Serv, New York, NY USA.
EM zollas01@nyumc.org
RI Morris, Daryl/H-2659-2013; Tomaras, Georgia/J-5041-2016;
OI Korber, Bette/0000-0002-2026-5757
FU NIH [HL59725, AI084119, U01, UM1AI-068618]; Military HIV Research
Program (MHRP); Department of Veterans Affairs; Bill & Melinda Gates
Foundation Collaboration for AIDS Vaccine Discovery (CAVD); Interagency
Agreement between the U.S. Army Medical Research and Material Command
(USAMRMC) and the National Institutes of Allergy and Infectious Diseases
[Y1-AI-2642-12]; cooperative agreement between the Henry M. Jackson
Foundation for the Advancement of Military Medicine, Inc. and the U.S.
Department of Defense (DOD) [W81XWH-07-2-0067]; Center for HIV/AIDS
Vaccine Immunology [AI067854]
FX This study was supported in part by NIH grants HL59725 (SZP) and
AI084119 (TC), by a contract from the Military HIV Research Program
(MHRP) to the Fred Hutchinson Cancer Research Center and NYU, by
research funds from the Department of Veterans Affairs, the Bill &
Melinda Gates Foundation Collaboration for AIDS Vaccine Discovery
(CAVD), grants to DCM, RK, BFH and SZP, and by an Interagency Agreement
Y1-AI-2642-12 between the U.S. Army Medical Research and Material
Command (USAMRMC) and the National Institutes of Allergy and Infectious
Diseases. This work was also supported by a cooperative agreement
(W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the
Advancement of Military Medicine, Inc. and the U.S. Department of
Defense (DOD), by a U01-grant from the NIH, AI067854 (the Center for
HIV/AIDS Vaccine Immunology), and by NIH grant UM1AI-068618 to the HVTN
Laboratory Program. The opinions herein are those of the authors and
should not be construed as official or representing the views of the
U.S. Department of Health and Human Services, National Institute for
Allergy and Infectious Diseases, the Department of Defense, the
Department of the Army, or the Department of Veterans Affairs. The
funders had no role in the study design, data collection and analysis,
decision to publish or preparation of the manuscript.
NR 45
TC 65
Z9 66
U1 2
U2 20
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 17
PY 2013
VL 8
IS 1
AR e53629
DI 10.1371/journal.pone.0053629
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 073JI
UT WOS:000313738900015
PM 23349725
ER
PT J
AU Mancuso, JD
Bernardo, J
Mazurek, GH
AF Mancuso, James D.
Bernardo, John
Mazurek, Gerald H.
TI The Elusive "Gold" Standard for Detecting Mycobacterium tuberculosis
Infection
SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
LA English
DT Editorial Material
ID CONVERSION; TESTS
C1 [Mancuso, James D.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Bernardo, John] Boston Univ, Sch Med, Ctr Pulm, Boston, MA 02118 USA.
[Mazurek, Gerald H.] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA USA.
RP Mancuso, JD (reprint author), Walter Reed Army Inst Res, Silver Spring, MD USA.
OI Bernardo, John/0000-0002-3922-0559
NR 12
TC 11
Z9 11
U1 0
U2 3
PU AMER THORACIC SOC
PI NEW YORK
PA 61 BROADWAY, FL 4, NEW YORK, NY 10006 USA
SN 1073-449X
J9 AM J RESP CRIT CARE
JI Am. J. Respir. Crit. Care Med.
PD JAN 15
PY 2013
VL 187
IS 2
BP 122
EP 124
DI 10.1164/rccm.201211-2033ED
PG 3
WC Critical Care Medicine; Respiratory System
SC General & Internal Medicine; Respiratory System
GA 075YY
UT WOS:000313924600006
PM 23322793
ER
PT J
AU Campione, S
de Ceglia, D
Vincenti, MA
Scalora, M
Capolino, F
AF Campione, Salvatore
de Ceglia, Domenico
Vincenti, Maria Antonietta
Scalora, Michael
Capolino, Filippo
TI Electric field enhancement in epsilon-near-zero slabs under TM-polarized
oblique incidence
SO PHYSICAL REVIEW B
LA English
DT Article
ID ARTIFICIAL DIELECTRIC MEDIUM; PLASMONIC MATERIALS; OPTICAL-CONSTANTS;
LOW-PERMITTIVITY; BREWSTER ANGLE; COMPLEX-MODES; METAMATERIALS;
REFLECTION; RADIATION; ARRAYS
AB We investigate local-field enhancement phenomena in subwavelength, epsilon-near-zero (ENZ) slabs that do not exploit Fabry-Perot resonances. In particular, we study the linear response of engineered metamaterial slabs of finite thickness based on plasmonic nanoshells that show an ENZ band in the visible range, and naturally occurring materials (e.g., SiO2) that also display ENZ properties, under oblique, TM-polarized plane-wave incidence. We then introduce active gain material in engineered metamaterial slabs that adds peculiar spectral and angular features to transmission, reflection, and absorption properties, and leads to a further local-field enhancement. These findings are supported by two theoretical studies: First, a simple interface between two semi-infinite media, namely free space and a generic ENZ medium; then, an ENZ slab of finite thickness, with the aim of understanding the system's behavior when varying the ENZ properties as well as the incident angle. For either case we report three distinct physical conditions for which we explain spectral and angular features that might result in strong field enhancement. The gain-assisted metamaterial implementation has the potential of triggering and enhancing low-threshold nonlinear phenomena thanks to the large local fields found at specific frequency and angular bands. DOI: 10.1103/PhysRevB.87.035120
C1 [Campione, Salvatore; Capolino, Filippo] Univ Calif Irvine, Dept Elect Engn & Comp Sci, Irvine, CA 92697 USA.
[de Ceglia, Domenico; Vincenti, Maria Antonietta] Aegis Technol Inc, Huntsville, AL 35806 USA.
[de Ceglia, Domenico; Vincenti, Maria Antonietta; Scalora, Michael] USA, Charles M Bowden Res Ctr, RDECOM, Huntsville, AL 35898 USA.
RP Campione, S (reprint author), Univ Calif Irvine, Dept Elect Engn & Comp Sci, Irvine, CA 92697 USA.
EM f.capolino@uci.edu
RI Campione, Salvatore/A-2349-2015
OI Campione, Salvatore/0000-0003-4655-5485
NR 38
TC 28
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U1 2
U2 57
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 2469-9950
EI 2469-9969
J9 PHYS REV B
JI Phys. Rev. B
PD JAN 15
PY 2013
VL 87
IS 3
AR 035120
DI 10.1103/PhysRevB.87.035120
PG 11
WC Physics, Condensed Matter
SC Physics
GA 070XJ
UT WOS:000313547100001
ER
PT J
AU Mountney, A
Leung, LY
Pedersen, R
Shear, D
Torte, F
AF Mountney, Andrea
Leung, Lai Yee
Pedersen, Rebecca
Shear, Deborah
Torte, Frank
TI Longitudinal assessment of gait abnormalities following penetrating
ballistic-like brain injury in rats
SO JOURNAL OF NEUROSCIENCE METHODS
LA English
DT Article
DE TBI; CatWalk; Gait analysis; PBBI; Longitudinal profile
ID MODEL; STROKE; MOTOR; IMPAIRMENT; LOCOMOTION; MOVEMENT; RECOVERY;
DEFICITS; NUCLEUS; LESIONS
AB Traumatic brain injury (TBI) results in enduring motor and cognitive dysfunction. Although gait disturbances have been documented among TBI patients, few studies have profiled gait abnormalities in animal models of TBI. We sought to obtain a comprehensive longitudinal analysis of gait function following severe penetrating ballistic-like brain injury (PBBI) in rats. Rats were subjected to either unilateral frontal PBBI, probe insertion alone, or sham surgery. Sensorimotor performance was assessed using the CatWalk automated gait analysis system. Baseline measurements were taken 3 days prior to injury and detailed analysis of gait was performed at 1, 3, 7, 14, and 28 days post-injury. Both PBBI and probe-inserted rats displayed altered static and dynamic gait parameters that were primarily evident during the early (<7 days) post-injury phase and were resolved by 1 month post-injury. PBBI produced more severe deficits compared to probe-alone which were reflected in the number, magnitude, and resolution time of abnormal gait parameters. While altered parameters were detected in all four paws, they were more apparent on the contralateral side. Gait parameters including paw pressure, print area, swing speed, and stride length were significantly decreased whereas stance, swing, and step cycle duration were increased compared to sham. Overall, altered gait patterns detected using the CatWalk system in the PBBI model were injury-severity dependent, resolved at later time points, and appeared similar to those reported in severe TBI patients. These results indicate that the CatWalk may be most useful for neuroprotection studies that focus on the acute/subacute recovery period after TBI. Published by Elsevier B.V.
C1 [Mountney, Andrea; Leung, Lai Yee; Pedersen, Rebecca; Shear, Deborah; Torte, Frank] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Nemorestorat Branch, Silver Spring, MD 20910 USA.
RP Mountney, A (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Nemorestorat Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM Andrea.Mountney@amedd.army.mil
RI Leung, Lai Yee/H-8204-2013
FU Army Combat Casualty Care Research Program; National Research Council
Research Associateship Award at Walter Reed Army Institute of Research
FX The authors are grateful for the technical assistance provided by
Weihong Yang. This research was funded by the Army Combat Casualty Care
Research Program and performed while the author held a National Research
Council Research Associateship Award at Walter Reed Army Institute of
Research
NR 36
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U1 0
U2 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0270
J9 J NEUROSCI METH
JI J. Neurosci. Methods
PD JAN 15
PY 2013
VL 212
IS 1
BP 1
EP 16
DI 10.1016/j.jneumeth.2012.08.025
PG 16
WC Biochemical Research Methods; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 068UB
UT WOS:000313390600001
PM 22981945
ER
PT J
AU Singh, RSP
Das, U
Auschwitz, JM
Leed, SE
Hickman, MR
Dimmock, JR
Alcorn, J
AF Singh, Ravi S. P.
Das, Umashankar
Auschwitz, Jennifer M.
Leed, Susan E.
Hickman, Mark R.
Dimmock, Jonathan R.
Alcorn, Jane
TI From a cytotoxic agent to the discovery of a novel antimalarial agent
SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
LA English
DT Article
DE Antimalarial; 3,5-Bis(benzylidene)-4-piperidones; CACO-2 cells; Drug
resistance; Glutathione; Plasmodium falciparum
ID MALARIA
AB A novel cytotoxin 3,5-bis(4-chlorobenzylidene)-1-[4-{2-(4-morpholinyl)ethoxy}phenyl-carbonyl]-4-piperidone hydrochloride 2 demonstrated potent antimalarial properties with IC50 values of 0.60 and 1.97 mu M against the drug sensitive D6 strain and the C235 drug-resistant strain of Plasmodium falciparum. This compound concentrates in red blood cells, lowers glutathione concentrations in erythrocytes and permeates across CACO-2 cells. These data reveal 2 to be a promising lead compound in the quest for novel antimalarial agents. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Singh, Ravi S. P.; Das, Umashankar; Dimmock, Jonathan R.; Alcorn, Jane] Univ Saskatchewan, Coll Pharm & Nutr, Drug Design & Discovery Res Grp, Saskatoon, SK S7N 5C9, Canada.
[Auschwitz, Jennifer M.; Leed, Susan E.; Hickman, Mark R.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA.
RP Alcorn, J (reprint author), Univ Saskatchewan, Coll Pharm & Nutr, Drug Design & Discovery Res Grp, Saskatoon, SK S7N 5C9, Canada.
EM jane.alcorn@usask.ca
RI Singh, Ravi Shankar /L-9408-2014
OI Singh, Ravi Shankar /0000-0001-6298-8219
FU Canadian Institutes of Health Research [ROP-53171]; Forge Ahead Fund
from the Industry Liaison Office at the University of Saskatchewan;
College of Graduate Studies and Research, University of Saskatchewan
FX The Canadian Institutes of Health Research (ROP-53171) and the Forge
Ahead Fund from the Industry Liaison Office at the University of
Saskatchewan funded this project. Dr. Wolfgang Koester and Dr. Taseen
Desin, VIDO, University of Saskatchewan are thanked for their support in
establishing the CACO-2 cells. We thank Jatinder Kaur Mukker and Deborah
Michel for their assistance. The Walter Reed Army Institute of Research
kindly undertook the evaluation of 2 against the D6 and C235 strains of
Plasmodium falciparum. The opinions in this publication of authors at
the Walter Reed Army Institute of Research are solely those of the
authors and do not reflect the views of the US Department of Defense.
R.S.P. Singh was supported by a Dean's scholarship from the College of
Graduate Studies and Research, University of Saskatchewan.
NR 18
TC 1
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U1 0
U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0960-894X
J9 BIOORG MED CHEM LETT
JI Bioorg. Med. Chem. Lett.
PD JAN 15
PY 2013
VL 23
IS 2
BP 584
EP 587
DI 10.1016/j.bmcl.2012.10.126
PG 4
WC Chemistry, Medicinal; Chemistry, Organic
SC Pharmacology & Pharmacy; Chemistry
GA 062YD
UT WOS:000312959600041
PM 23228469
ER
PT J
AU Kragh-Buetow, KC
Weng, X
Readinger, ED
Wraback, M
Mohney, SE
AF Kragh-Buetow, K. C.
Weng, X.
Readinger, E. D.
Wraback, M.
Mohney, S. E.
TI Effect of polarity on Ni/InN interfacial reactions
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID T-METALLE MANGAN; STICKSTOFFLEGIERUNGEN; EISEN
AB Ni films on (0001) and (000 (1) over bar) InN exhibited different reaction kinetics upon annealing at 673K. Structural and chemical analysis using grazing incidence X-ray diffraction, transmission electron microscopy, and X-ray energy dispersive spectrometry indicated that an interfacial reaction did not occur between the Ni film and the In-polar (0001) InN layer. However, the N-polar face reacted with Ni to form the Ni3InNx ternary phase with an anti-perovskite structure. The difference in reactivity for Ni on In-face and N-face InN indicates that polarity alters the reaction and may also affect interactions between other metals and group III-nitride semiconductors. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4781768]
C1 [Kragh-Buetow, K. C.; Mohney, S. E.] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA.
[Weng, X.; Mohney, S. E.] Penn State Univ, Mat Res Inst, University Pk, PA 16802 USA.
[Readinger, E. D.; Wraback, M.] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Mohney, SE (reprint author), Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA.
EM sem2@psu.edu
RI weng, xiaojun/D-5096-2011
FU 3M Corporation; NASA
FX Gratitude is expressed to Jillian Woolridge for assistance with
translating literature from German, and Nichole Wonderling for
assistance with X-ray diffraction. K. C. Kragh-Buetow appreciates
funding from the 3M Corporation and NASA.
NR 10
TC 0
Z9 0
U1 0
U2 22
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0003-6951
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD JAN 14
PY 2013
VL 102
IS 2
AR 021607
DI 10.1063/1.4781768
PG 4
WC Physics, Applied
SC Physics
GA 072KQ
UT WOS:000313670200018
ER
PT J
AU Chantawansri, TL
Sirk, TW
Sliozberg, YR
AF Chantawansri, Tanya L.
Sirk, Timothy W.
Sliozberg, Yelena R.
TI Entangled triblock copolymer gel: Morphological and mechanical
properties
SO JOURNAL OF CHEMICAL PHYSICS
LA English
DT Article
ID DISSIPATIVE PARTICLE DYNAMICS; MOLECULAR-DYNAMICS; SELECTIVE SOLVENT;
DIBLOCK COPOLYMERS; BLOCK-COPOLYMER; VISCOELASTIC PROPERTIES; POLYMER
NETWORKS; DPD SIMULATION; PHASE-BEHAVIOR; AGGREGATION
AB The morphological and mechanical properties of entangled ABA triblock copolymer gels, where solvent were selective to the midblock, were studied as a function of polymer concentration using a novel dissipative particle dynamics model which includes a modified segmental repulsive potential that restricts chain crossing. Morphological properties, such as micelle size, distance between micelles, and the bridge fraction, were calculated as a function of concentration. Although the micelle size was shown to have a strong dependence on concentration, the bridge fraction and distance between micelles were shown to plateau at moderate concentrations. Deformation under uni-axial tension was also performed to extract the cross-link and entanglement contribution to the elastic modulus. Scaling results qualitatively agree with other theoretical predications. [http://dx.doi.org/10.1063/1.4774373]
C1 [Chantawansri, Tanya L.; Sirk, Timothy W.; Sliozberg, Yelena R.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Chantawansri, TL (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RI Chantawansri, Tanya/N-3601-2013
FU U.S. Army Research Laboratory Enterprise for Multi-scale Research of
Materials
FX This work was partially funded by the U.S. Army Research Laboratory
Enterprise for Multi-scale Research of Materials. Y.R.S. and T. W. S.
were partially supported in part by an appointment to the Postgraduate
Research Participation Program at the U.S. Army Research Laboratory
administered by the Oak Ridge Institute for Science and Education
through an interagency agreement between the U.S. Department of Energy
and USARL. Calculations were performed on DOD High Performance Computing
site at the AFRL through the Challenge Project C5M.
NR 56
TC 10
Z9 10
U1 6
U2 62
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0021-9606
J9 J CHEM PHYS
JI J. Chem. Phys.
PD JAN 14
PY 2013
VL 138
IS 2
AR 024908
DI 10.1063/1.4774373
PG 10
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA 072BF
UT WOS:000313642500067
PM 23320722
ER
PT J
AU Bykhovski, A
Zhang, WD
Jensen, J
Woolard, D
AF Bykhovski, Alexei
Zhang, Weidong
Jensen, James
Woolard, Dwight
TI Analysis of Electronic Structure, Binding, and Vibrations in
Biotin-Streptavidin Complexes Based on Density Functional Theory and
Molecular Mechanics
SO JOURNAL OF PHYSICAL CHEMISTRY B
LA English
DT Article
ID DYNAMICS; ENERGY; POTENTIALS; PROTEINS; ABSOLUTE
AB In this work, the biotin-streptavidin complex was studied with density functional theory (DFT), molecular mechanical methods (MM), and a hybrid DFT/MM approach in order to obtain the theoretical predictions for electronic structures, binding, optical transitions, harmonic vibrations, and absorption spectra. It was demonstrated that biotin solvation in water can reduce the binding strength to streptavidin by more than half. All studied properties, including the biotin binding and the UV absorption of the biotin-streptavidin complex, are predicted to be protonation state depen-
dent. The absorption edge of the complex calculated with TDDFT/MM was found to be virtually insensitive to the choice of the MM force field and strongly dependent on the type of embedding of the DFT partition. Both UV and terahertz light absorption spectra are predicted to be sensitive to the presence of biotin in the streptavidin tetramer.
C1 [Bykhovski, Alexei; Zhang, Weidong; Woolard, Dwight] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA.
[Jensen, James] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
[Woolard, Dwight] USA, Res Off, Res Triangle Pk, NC 27709 USA.
RP Bykhovski, A (reprint author), N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA.
EM abykhov@ncsu.edu
FU U.S. Army Research Laboratory (ARL); National Research Council (NRC)
FX This work was supported by a U.S. Army Research Laboratory (ARL) award
and by a National Research Council (NRC) fellowship.
NR 27
TC 4
Z9 4
U1 1
U2 35
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1520-6106
J9 J PHYS CHEM B
JI J. Phys. Chem. B
PD JAN 10
PY 2013
VL 117
IS 1
BP 25
EP 37
DI 10.1021/jp3075833
PG 13
WC Chemistry, Physical
SC Chemistry
GA 066KV
UT WOS:000313220600004
PM 23214720
ER
PT J
AU Fox, ET
Paillard, E
Borodin, O
Henderson, WA
AF Fox, Eric T.
Paillard, Elie
Borodin, Oleg
Henderson, Wesley A.
TI Physicochemical Properties of Binary Ionic Liquid-Aprotic Solvent
Electrolyte Mixtures
SO JOURNAL OF PHYSICAL CHEMISTRY C
LA English
DT Article
ID NANOSTRUCTURAL ORGANIZATION; ORGANIC-SOLVENTS; PLUS ETHANOL; 313.15 K;
VISCOSITY; WATER; CONDUCTIVITY; PERFORMANCE; CHLORIDE; ESTERS
AB The properties of mixtures of ionic liquids (ILs) with a variety of different aprotic solvents have been examined in detail. The ILs selected bis(trifluoromethanesulfonyl)imide (TFSI-) salts with N-methyl-N-pentylpyrrolidinium (PY15+), -piperidinium (PI15+), or -morpholinium (MO15+) cations enabled the investigation of how cation structure influences the mixture properties. This study includes the characterization of the thermal phase behavior of the mixtures and volatility of the solvents, density and excess molar volume, and transport properties (viscosity and conductivity). The mixtures with ethylene carbonate form a simple eutectic, whereas those with ethyl butyrate appear to form a new IL-solvent crystalline phase. Significant differences in the viscosity of the mixtures are found for different solvents, especially for the IL-rich concentrations. In contrast, only minor differences are noted for the conductivity with different solvents for the IL-rich concentrations. For the solvent-rich concentrations, however, substantial differences are noted in the conductivity, especially for the mixtures with acetonitrile.
C1 [Fox, Eric T.; Paillard, Elie; Henderson, Wesley A.] N Carolina State Univ, Dept Chem & Biomol Engn, ILEET Lab, Raleigh, NC 27695 USA.
[Borodin, Oleg] USA, Electrochem Branch, Sensor & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA.
RP Henderson, WA (reprint author), N Carolina State Univ, Dept Chem & Biomol Engn, ILEET Lab, Raleigh, NC 27695 USA.
EM whender@ncsu.edu
RI Borodin, Oleg/B-6855-2012; Paillard, Elie/F-6798-2015
OI Borodin, Oleg/0000-0002-9428-5291; Paillard, Elie/0000-0002-5630-0569
FU U.S. Department of Energy, Office of Basic Energy Sciences, Division of
Materials Sciences and Engineering [DE-DC0001912]; U.S. Department of
Energy; U.S. Army Research Laboratory [DE-IA01-11EE003413]
FX The authors express their gratitude to the U.S. Department of Energy,
Office of Basic Energy Sciences, Division of Materials Sciences and
Engineering, which fully supported the experimental research under Award
DE-DC0001912. The preliminary computational work was partially supported
by an Interagency Agreement between the U.S. Department of Energy and
the U.S. Army Research Laboratory under DE-IA01-11EE003413 for the
Office of Vehicle Technologies Programs including the Batteries for
Advanced Transportation Technologies (BATT) Program.
NR 37
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U1 2
U2 72
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1932-7447
J9 J PHYS CHEM C
JI J. Phys. Chem. C
PD JAN 10
PY 2013
VL 117
IS 1
BP 78
EP 84
DI 10.1021/jp3089403
PG 7
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA 066KW
UT WOS:000313220700011
ER
PT J
AU Baril, N
Billman, C
Maloney, P
Nallon, E
Tidrow, M
Pellegrino, J
Bandara, S
AF Baril, Neil
Billman, Curtis
Maloney, Patrick
Nallon, Eric
Tidrow, Meimei
Pellegrino, Joseph
Bandara, Sumith
TI Optimization of thickness and doping of heterojunction unipolar barrier
layer for dark current suppression in long wavelength strain layer
superlattice infrared detectors
SO APPLIED PHYSICS LETTERS
LA English
DT Article
AB Suppression of generation-recombination dark current and bias stability in long wavelength infrared (LWIR) strained layer superlattice (SLS) detectors, consisting of a lightly doped p-type absorber layer and a wide bandgap hole barrier, are investigated with respect to the wide bandgap barrier layer thickness and doping profile. Dark current IV, photoresponse, and theoretical modeling are used to correlate device performance with the widegap barrier design parameters. Decreased dark current density and increased operating bias were observed as the barrier thickness was increased. This study also identifies key device parameters responsible for optimal performance of heterojunction based SLS LWIR detector. [http://dx.doi.org/10.1063/1.4775376]
C1 [Baril, Neil] Corbin Co, Alexandria, VA 22314 USA.
[Baril, Neil; Billman, Curtis; Maloney, Patrick; Nallon, Eric; Tidrow, Meimei; Pellegrino, Joseph; Bandara, Sumith] USA, RDECOM, CERDEC, NVESD, Ft Belvoir, VA 22060 USA.
RP Bandara, S (reprint author), USA, RDECOM, CERDEC, NVESD, Ft Belvoir, VA 22060 USA.
EM info@nvl.army.mil
NR 13
TC 6
Z9 6
U1 2
U2 16
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0003-6951
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD JAN 7
PY 2013
VL 102
IS 1
AR 013509
DI 10.1063/1.4775376
PG 4
WC Physics, Applied
SC Physics
GA 072CQ
UT WOS:000313646500131
ER
PT J
AU Suchalkin, S
Jung, S
Tober, R
Belkin, MA
Belenky, G
AF Suchalkin, S.
Jung, S.
Tober, R.
Belkin, M. A.
Belenky, G.
TI Optically tunable long wavelength infrared quantum cascade laser
operated at room temperature
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID WAVE-GUIDES; FREQUENCY
AB We demonstrate rapid tuning of the emission frequency of a room-temperature mid-infrared quantum cascade laser by external optical pumping. Emission frequency tuning over 0.3 cm(-1) (10GHz) has been achieved for a lambda = 9 mu m device by optical generation of electron-hole pairs along the entire length of the laser stripe. Measurements indicate that this approach allows for rapid broadband frequency-modulation of mid-infrared quantum cascade lasers at above 300MHz modulation frequencies. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4774267]
C1 [Suchalkin, S.; Jung, S.; Belenky, G.] SUNY Stony Brook, Dept Elect & Comp Engn, Stony Brook, NY 11794 USA.
[Tober, R.] Univ Texas Austin, Dept Elect & Comp Engn, Austin, TX 78759 USA.
[Belkin, M. A.] USA, Res Lab, Adelphi, MD 20873 USA.
RP Suchalkin, S (reprint author), SUNY Stony Brook, Dept Elect & Comp Engn, Stony Brook, NY 11794 USA.
RI Belkin, Mikhail/E-9041-2013
OI Belkin, Mikhail/0000-0003-3172-9462
FU National Science Foundation [ECCS 1028435, ECCS 1028473]
FX We wish to thank Professor B. Laikhtman for stimulating discussions.
This work was supported by National Science Foundation Grant Nos. ECCS
1028435 and ECCS 1028473.
NR 18
TC 7
Z9 7
U1 0
U2 30
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0003-6951
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD JAN 7
PY 2013
VL 102
IS 1
AR 011125
DI 10.1063/1.4774267
PG 4
WC Physics, Applied
SC Physics
GA 072CQ
UT WOS:000313646500025
ER
PT J
AU Vincenti, MA
Grande, M
Bianco, GV
de Ceglia, D
Stomeo, T
De Vittorio, M
Petruzzelli, V
Bruno, G
D'Orazio, A
Scalora, M
AF Vincenti, M. A.
Grande, M.
Bianco, G. V.
de Ceglia, D.
Stomeo, T.
De Vittorio, M.
Petruzzelli, V.
Bruno, G.
D'Orazio, A.
Scalora, M.
TI Surface-enhanced Raman scattering from finite arrays of gold
nano-patches
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
ID SINGLE-MOLECULE; SERS; NANOPARTICLES
AB We experimentally investigate the surface-enhanced Raman scattering (SERS) response of a 2D-periodic array of square gold nano-patches, functionalized by means of a conjugated, rigid thiol. We measure a Raman signal enhancement up to 200 times more intense compared to other plasmon-based nanostructures functionalized with the same molecule, and show that the enhancement is not strictly correlated to the presence of plasmonic resonances. The agreement between experimental and theoretical results reveals the importance of a full-wave analysis based on the inclusion of the actual scattering cross section of the molecule. The proposed numerical approach may serve not only as a tool to predict the enhancement of Raman signal scattered from strongly resonant nanostructure but also as an effective instrument to engineer SERS platforms that target specific molecules. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4772725]
C1 [Vincenti, M. A.; de Ceglia, D.] AEgis Technol Inc, Huntsville, AL 35806 USA.
[Vincenti, M. A.; de Ceglia, D.; Scalora, M.] USA, Charles M Bowden Res Lab, Huntsville, AL USA.
[Grande, M.; Petruzzelli, V.; D'Orazio, A.] Politecn Bari, Dipartimento Elettrotecn & Elettron, I-70125 Bari, Italy.
[Bianco, G. V.; Bruno, G.] IMIP CNR, I-70126 Bari, Italy.
[Stomeo, T.; De Vittorio, M.] Ist Italiano Technol IIT, Ctr Biomol Nanotechnol, I-73010 Lecce, Italy.
[De Vittorio, M.] Univ Salento, Dip Ingn Innovaz, CNR Ist Nanosci, Natl Nanotechnol Lab NNL, I-73010 Lecce, Italy.
RP Vincenti, MA (reprint author), AEgis Technol Inc, 410 Jan Davis Dr, Huntsville, AL 35806 USA.
EM mvincenti@aegistg.com
RI Petruzzelli, Vincenzo/E-5576-2015; Petruzzelli, Vincenzo/H-5188-2012; De
Vittorio, Massimo/I-5250-2012;
OI Petruzzelli, Vincenzo/0000-0001-6921-9981; Petruzzelli,
Vincenzo/0000-0001-6921-9981; De Vittorio, Massimo/0000-0003-1601-6392;
BIANCO, GIUSEPPE VALERIO/0000-0002-0986-1531; BRUNO,
GIOVANNI/0000-0003-3116-1176
FU National Research Council at the U.S. Army Aviation and Missile Research
Development and Engineering Center; U.S. Army International Technology
Center Atlantic
FX This research was performed while the authors M. A. Vincenti and D. de
Ceglia held a National Research Council Research Associateship award at
the U.S. Army Aviation and Missile Research Development and Engineering
Center. M. Grande thanks the U.S. Army International Technology Center
Atlantic for financial support.
NR 25
TC 5
Z9 5
U1 2
U2 47
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0021-8979
J9 J APPL PHYS
JI J. Appl. Phys.
PD JAN 7
PY 2013
VL 113
IS 1
AR 013103
DI 10.1063/1.4772725
PG 5
WC Physics, Applied
SC Physics
GA 067XQ
UT WOS:000313329000004
ER
PT J
AU Douglas, TA
Blum, JD
Guo, LD
Keller, K
Gleason, JD
AF Douglas, Thomas A.
Blum, Joel D.
Guo, Laodong
Keller, Katy
Gleason, James D.
TI Hydrogeochemistry of seasonal flow regimes in the Chena River, a
subarctic watershed draining discontinuous permafrost in interior Alaska
(USA)
SO CHEMICAL GEOLOGY
LA English
DT Article
DE Permafrost biogeochemistry; River chemistry; Nutrients; Seasonality;
Weathering geochemistry
ID CLIMATE-CHANGE; ORGANIC-CARBON; ISOTOPE COMPOSITION; ALPINE CATCHMENT;
BOREAL FORESTS; NORTH-AMERICA; ACTIVE LAYER; TEMPERATURE; FLUXES;
BIOGEOCHEMISTRY
AB Thawing of permafrost and a shift in the timing of major seasonal transitions (spring melt and fall freeze-up) are two anticipated effects of climate warming in northern regions. These fundamental changes in terrestrial ecosystems could have major ramifications for the timing and fluxes of carbon and nutrient exports from watersheds and the geochemical signatures of northern rivers. Discontinuous permafrost, which underlies watersheds in Interior Alaska (USA), is expected to degrade rapidly in response to climate warming and this will likely alter subsurface flows and flow paths, water residence times, water-soil, and water-rock interactions. This study of the Chena River in Interior Alaska was undertaken to quantify dissolved organic carbon (DOC), total dissolved nitrogen (TDN), major ion, strontium isotope, and stable oxygen and hydrogen isotope values during two year-long time series sampling periods. Our goal was to identify the hydrogeochemical signatures associated with the major seasonal flow regimes. Periods of increased discharge such as spring melt and major summer precipitation events yielded elevated DOC and TON concentrations, diluted major ion concentrations, and shifted stable oxygen and hydrogen isotope ratios from base flow toward precipitation values. During dry summer periods nutrient concentrations decreased and strontium isotope values were indicative of a higher proportion of silicate versus carbonate mineral dissolution. Winter base flow had a unique geochemical signal with a slight increase in TDN concentrations compared to typical summer conditions, and a lower proportion of silicate versus carbonate mineral dissolution. Since flow paths in subarctic watersheds can change dramatically over the course of a year we interpreted our results within the context of a schematic model for subsurface flow to identify how permafrost degradation might affect nutrient exports and hydrogeochemical patterns in these watersheds. Published by Elsevier B.V.
C1 [Douglas, Thomas A.] USA, Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA.
[Blum, Joel D.; Keller, Katy; Gleason, James D.] Univ Michigan, Dept Earth & Environm Sci, Ann Arbor, MI 48109 USA.
[Guo, Laodong] Univ Wisconsin, Sch Freshwater Sci, Milwaukee, WI 53204 USA.
RP Douglas, TA (reprint author), USA, Cold Reg Res & Engn Lab, POB 35170, Ft Wainwright, AK 99703 USA.
EM Thomas.A.Douglas@usace.army.mil
RI Guo, Laodong/F-6045-2010
OI Guo, Laodong/0000-0002-5010-1630
FU U.S. Army Alaska Directorate of Public Works
FX We thank Yihua Cai, Mindy Juliana, Art Gelvin, and Laura Johnson for
their assistance with field sampling. Zhengzhen Zhou helped with the DOC
and TDN analysis. Amanda Barker commented on an earlier version of this
manuscript. Two reviewers provided constructive comments that
strengthened an earlier version of this manuscript and their efforts are
greatly appreciated. Funding was provided by the U.S. Army Alaska
Directorate of Public Works. Chris Hiemstra and Rainer Newberry helped
us with development of the geologic map of the watershed.
NR 86
TC 12
Z9 13
U1 0
U2 64
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0009-2541
J9 CHEM GEOL
JI Chem. Geol.
PD JAN 6
PY 2013
VL 335
BP 48
EP 62
DI 10.1016/j.chemgeo.2012.10.045
PG 15
WC Geochemistry & Geophysics
SC Geochemistry & Geophysics
GA 077GJ
UT WOS:000314015600005
ER
PT J
AU Kreit, E
Mathger, LM
Hanlon, RT
Dennis, PB
Naik, RR
Forsythe, E
Heikenfeld, J
AF Kreit, Eric
Maethger, Lydia M.
Hanlon, Roger T.
Dennis, Patrick B.
Naik, Rajesh R.
Forsythe, Eric
Heikenfeld, Jason
TI Biological versus electronic adaptive coloration: how can one inform the
other?
SO JOURNAL OF THE ROYAL SOCIETY INTERFACE
LA English
DT Review
DE adaptive coloration; reflective coloration; cephalopod; reflective
displays
ID AVIAN FEATHER BARBS; SQUID IRIDOPHORES; RECEPTOR NOISE; DISPLAYS;
CAMOUFLAGE; CHROMATOPHORES; REFLECTANCE; MODEL; NANOSTRUCTURES;
CEPHALOPODS
AB Adaptive reflective surfaces have been a challenge for both electronic paper (e-paper) and biological organisms. Multiple colours, contrast, polarization, reflectance, diffusivity and texture must all be controlled simultaneously without optical losses in order to fully replicate the appearance of natural surfaces and vividly communicate information. This review merges the frontiers of knowledge for both biological adaptive coloration, with a focus on cephalopods, and synthetic reflective e-paper within a consistent framework of scientific metrics. Currently, the highest performance approach for both nature and technology uses colourant transposition. Three outcomes are envisioned from this review: reflective display engineers may gain new insights from millions of years of natural selection and evolution; biologists will benefit from understanding the types of mechanisms, characterization and metrics used in synthetic reflective e-paper; all scientists will gain a clearer picture of the long-term prospects for capabilities such as adaptive concealment and signalling.
C1 [Kreit, Eric; Heikenfeld, Jason] Univ Cincinnati, Sch Elect & Comp Syst, Novel Devices Lab, Cincinnati, OH 45221 USA.
[Maethger, Lydia M.; Hanlon, Roger T.] Marine Biol Lab, Woods Hole, MA 02543 USA.
[Dennis, Patrick B.; Naik, Rajesh R.] USAF, Mat & Mfg Directorate, Res Lab, Dayton, OH 45433 USA.
[Forsythe, Eric] USA, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA.
RP Heikenfeld, J (reprint author), Univ Cincinnati, Sch Elect & Comp Syst, Novel Devices Lab, Cincinnati, OH 45221 USA.
EM heikenjc@ucmail.uc.edu
RI Hanlon, Roger/Q-8687-2016
OI Hanlon, Roger/0000-0003-0004-5674
FU AFRL [5408-25-SC-0003]; NSF [0640964]; NSF IHCS [1001141]; ARL
[W9111NF-09-2-0034, W911NF-09-2-0043]; AFOSR [FA9550-09-0346]; DARPA
(DSO) [W911NF-10-1-0113]; ONR [N00014-10-1-0989]
FX E.K., J.H. and E. F. created content on technological (synthetic)
aspects of adaptive coloration while L. M. M., R. T. H., P. B. D. and
R.R.N. focused on the biological content. E. K. organized and compiled
the sections into the main paper, and worked with J.H. on the
comparisons section at the end. All authors discussed the information
presented in the paper at all stages, with the exception of E. F. who
made significant contributions at later stages. The University of
Cincinnati authors gratefully acknowledge partial support from AFRL
(contract no. 5408-25-SC-0003) NSF Career award (no. 0640964; University
of Cincinnati), NSF IHCS award (no. 1001141) and ARL (grant no.
W9111NF-09-2-0034). MBL authors acknowledge support from AFOSR grant no.
FA9550-09-0346, ARL grant no. W911NF-09-2-0043, DARPA (DSO) grant no.
W911NF-10-1-0113 and ONR grant no. N00014-10-1-0989. R.R.N. acknowledges
support from AFOSR.
NR 74
TC 18
Z9 18
U1 4
U2 83
PU ROYAL SOC
PI LONDON
PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND
SN 1742-5689
EI 1742-5662
J9 J R SOC INTERFACE
JI J. R. Soc. Interface
PD JAN 6
PY 2013
VL 10
IS 78
AR 20120601
DI 10.1098/rsif.2012.0601
PG 13
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 048UT
UT WOS:000311939400013
PM 23015522
ER
PT J
AU Gao, GF
Wieczorek, L
Peachman, KK
Polonis, VR
Alving, CR
Rao, M
Rao, VB
AF Gao, Guofen
Wieczorek, Lindsay
Peachman, Kristina K.
Polonis, Victoria R.
Alving, Carl R.
Rao, Mangala
Rao, Venigalla B.
TI Designing a Soluble Near Full-length HIV-1 gp41 Trimer
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID HUMAN-IMMUNODEFICIENCY-VIRUS; PROXIMAL EXTERNAL REGION; BROADLY
NEUTRALIZING ANTIBODIES; ENVELOPE GLYCOPROTEIN; MONOCLONAL-ANTIBODY;
TYPE-1 ENVELOPE; INTEGRIN ALPHA(4)BETA(7); CONFORMATIONAL-CHANGES;
IMMUNODOMINANT DOMAIN; MEMBRANE-FUSION
AB The HIV-1 envelope spike is a trimer of heterodimers composed of an external glycoprotein gp120 and a transmembrane glycoprotein gp41. gp120 initiates virus entry by binding to host receptors, whereas gp41 mediates fusion between viral and host membranes. Although the basic pathway of HIV-1 entry has been extensively studied, the detailed mechanism is still poorly understood. Design of gp41 recombinants that mimic key intermediates is essential to elucidate the mechanism as well as to develop potent therapeutics and vaccines. Here, using molecular genetics and biochemical approaches, a series of hypotheses was tested to overcome the extreme hydrophobicity of HIV-1 gp41 and design a soluble near full-length gp41 trimer. The two long heptad repeat helices HR1 and HR2 of gp41 ectodomain were mutated to disrupt intramolecular HR1-HR2 interactions but not intermolecular HR1-HR1 interactions. This resulted in reduced aggregation and improved solubility. Attachment of a 27-amino acid foldon at the C terminus and slow refolding channeled gp41 into trimers. The trimers appear to be stabilized in a prehairpin-like structure, as evident from binding of a HR2 peptide to exposed HR1 grooves, lack of binding to hexa-helical bundle specific NC-1 mAb, and inhibition of virus neutralization by broadly neutralizing antibodies 2F5 and 4E10. Fusion to T4 small outer capsid protein, Soc, allowed display of gp41 trimers on the phage nanoparticle. These approaches for the first time led to the design of a soluble gp41 trimer containing both the fusion peptide and the cytoplasmic domain, providing insights into the mechanism of entry and development of gp41-based HIV-1 vaccines.
C1 [Gao, Guofen; Rao, Venigalla B.] Catholic Univ Amer, Dept Biol, Washington, DC 20064 USA.
[Wieczorek, Lindsay; Peachman, Kristina K.] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
[Polonis, Victoria R.; Alving, Carl R.; Rao, Mangala] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
RP Rao, VB (reprint author), Catholic Univ Amer, Dept Biol, 620 Michigan Ave NE, Washington, DC 20064 USA.
EM rao@cua.edu
FU National Institutes of Health [R01AI02725 (NIAID)]
FX This work was supported in part by National Institutes of Health Grant
R01AI02725 (NIAID).
NR 69
TC 8
Z9 8
U1 1
U2 44
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD JAN 4
PY 2013
VL 288
IS 1
BP 234
EP 246
DI 10.1074/jbc.M112.424432
PG 13
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 066CJ
UT WOS:000313197200023
PM 23184960
ER
PT J
AU Xing, LD
Vatamanu, J
Borodin, O
Bedrov, D
AF Xing, Lidan
Vatamanu, Jenel
Borodin, Oleg
Bedrov, Dmitry
TI On the Atomistic Nature of Capacitance Enhancement Generated by Ionic
Liquid Electrolyte Confined in Subnanometer Pores
SO JOURNAL OF PHYSICAL CHEMISTRY LETTERS
LA English
DT Article
ID DOUBLE-LAYER CAPACITORS; MOLECULAR-DYNAMICS SIMULATION; DIFFERENTIAL
CAPACITANCE; ELECTROCHEMICAL CAPACITORS; GRAPHITE-ELECTRODES; SIZE;
CARBONS; SURFACE; SUPERCAPACITOR; NANOPORE
AB The capacitance enhancement experimentally observed in electrodes with complex morphology of random subnanometer wide pores is an intriguing phenomena, yet the mechanisms for such enhancement are not completely understood. Our atomistic molecular dynamics simulations demonstrate that in subnanometer slit-geometry nanopores, a factor of 2 capacitance enhancement (compared to a flat electrode) is possible for the 1-ethyl-3-methylimidazolium (EMIM)-bis(trifluoro-methylsulfonyl)imide (TFSI) ionic liquid electrolyte. This capacitance enhancement is a result of a fast charge separation inside the nanopore due to abrupt expulsion of co-ions from the pore while maintaining an elevated counterion density due to strong screening of electrostatic repulsive interactions by the conductive pore. Importantly, we find that the capacitance enhancement can be very asymmetric. For the negatively charged 7.5 angstrom wide pore, the integral capacitance is 100% larger than on a flat surface; however, on the positive electrode, almost no enhancement is observed. Detailed analysis of structure and composition of electrolyte inside nanopores shows that the capacitance enhancement and the shape of differential capacitance details of the ion chemical structure and a delicate balance of ion surface and ion ion interactions. strongly depend on the details of the ion chemical structure and a delicate balance of ion-surface and ion-ion interactions.
C1 [Xing, Lidan; Vatamanu, Jenel; Bedrov, Dmitry] Univ Utah, Dept Mat Sci & Engn, Salt Lake City, UT 84112 USA.
[Xing, Lidan] S China Normal Univ, Sch Chem & Environm, Guangzhou 510006, Guangdong, Peoples R China.
[Borodin, Oleg] USA, Electrochem Branch, Res Lab, Adelphi, MD 20783 USA.
RP Vatamanu, J (reprint author), Univ Utah, Dept Mat Sci & Engn, 122 S Cent Campus Dr, Salt Lake City, UT 84112 USA.
EM vatamanu.jenel@utah.edu; d.bedrov@utah.edu
RI Borodin, Oleg/B-6855-2012; Vatamanu, Jenel/I-7638-2012
OI Borodin, Oleg/0000-0002-9428-5291; Vatamanu, Jenel/0000-0003-0825-1608
FU Department of Energy [DE-SC0001912]; Office of Science of the U.S.
Department of Energy [DE-AC02-05CH11231]; Natural Science Foundation of
Guangdong Province, China [1035106310 1000001]
FX The authors are grateful to the Department of Energy under Contract
Grant DE-SC0001912 to the University of Utah. This research used
computational resources of the National Energy Research Scientific
Computing Center, which is supported by the Office of Science of the
U.S. Department of Energy under Contract No. DE-AC02-05CH11231. L.X.
acknowledges financial support of the Natural Science Foundation of
Guangdong Province, China (grant no. 1035106310 1000001).
NR 43
TC 48
Z9 50
U1 8
U2 142
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1948-7185
J9 J PHYS CHEM LETT
JI J. Phys. Chem. Lett.
PD JAN 3
PY 2013
VL 4
IS 1
BP 132
EP 140
DI 10.1021/jz301782f
PG 9
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary; Physics, Atomic, Molecular & Chemical
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA 065IM
UT WOS:000313142000023
PM 26291225
ER
PT J
AU Takala-Harrison, S
Clark, TG
Jacob, CG
Cummings, MP
Miotto, O
Dondorp, AM
Fukuda, MM
Nosten, F
Noedl, H
Imwong, M
Bethell, D
Se, Y
Lon, C
Tyner, SD
Saunders, DL
Socheat, D
Ariey, F
Phyo, AP
Starzengruber, P
Fuehrer, HP
Swoboda, P
Stepniewska, K
Flegg, J
Arze, C
Cerqueira, GC
Silva, JC
Ricklefs, SM
Porcella, SF
Stephens, RM
Adams, M
Kenefic, LJ
Campino, S
Auburn, S
Macinnis, B
Kwiatkowski, DP
Su, XZ
White, NJ
Ringwald, P
Plowe, CV
AF Takala-Harrison, Shannon
Clark, Taane G.
Jacob, Christopher G.
Cummings, Michael P.
Miotto, Olivo
Dondorp, Arjen M.
Fukuda, Mark M.
Nosten, Francois
Noedl, Harald
Imwong, Mallika
Bethell, Delia
Se, Youry
Lon, Chanthap
Tyner, Stuart D.
Saunders, David L.
Socheat, Duong
Ariey, Frederic
Phyo, Aung Pyae
Starzengruber, Peter
Fuehrer, Hans-Peter
Swoboda, Paul
Stepniewska, Kasia
Flegg, Jennifer
Arze, Cesar
Cerqueira, Gustavo C.
Silva, Joana C.
Ricklefs, Stacy M.
Porcella, Stephen F.
Stephens, Robert M.
Adams, Matthew
Kenefic, Leo J.
Campino, Susana
Auburn, Sarah
Macinnis, Bronwyn
Kwiatkowski, Dominic P.
Su, Xin-zhuan
White, Nicholas J.
Ringwald, Pascal
Plowe, Christopher V.
TI Genetic loci associated with delayed clearance of Plasmodium falciparum
following artemisinin treatment in Southeast Asia
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE drug resistance; genome-wide association; molecular markers
ID GENOME-WIDE; POPULATION-STRUCTURE; PARASITE CLEARANCE; POSITIVE
SELECTION; RESISTANT MALARIA; WESTERN CAMBODIA; ARTESUNATE; MEFLOQUINE;
REGIONS; LIGHT
AB The recent emergence of artemisinin-resistant Plasmodium falciparum malaria in western Cambodia could threaten prospects for malaria elimination. Identification of the genetic basis of resistance would provide tools for molecular surveillance, aiding efforts to contain resistance. Clinical trials of artesunate efficacy were conducted in Bangladesh, in northwestern Thailand near the Myanmar border, and at two sites in western Cambodia. Parasites collected from trial participants were genotyped at 8,079 single nucleotide polymorphisms (SNPs) using a P. falciparum-specific SNP array. Parasite genotypes were examined for signatures of recent positive selection and association with parasite clearance phenotypes to identify regions of the genome associated with artemisinin resistance. Four SNPs on chromosomes 10 (one), 13 (two), and 14 (one) were significantly associated with delayed parasite clearance. The two SNPs on chromosome 13 are in a region of the genome that appears to be under strong recent positive selection in Cambodia. The SNPs on chromosomes 10 and 13 lie in or near genes involved in postreplication repair, a DNA damage-tolerance pathway. Replication and validation studies are needed to refine the location of loci responsible for artemisinin resistance and to understand the mechanism behind it; however, two SNPs on chromosomes 10 and 13 may be useful markers of delayed parasite clearance in surveillance for artemisinin resistance in Southeast Asia.
C1 [Takala-Harrison, Shannon; Jacob, Christopher G.; Adams, Matthew; Kenefic, Leo J.; Plowe, Christopher V.] Univ Maryland, Sch Med, Howard Hughes Med Inst, Ctr Vaccine Dev, Baltimore, MD 21201 USA.
[Clark, Taane G.] London Sch Trop Med, Dept Pathogen Mol Biol, London WC1E 7HT, England.
[Cummings, Michael P.] Univ Maryland, Ctr Bioinformat & Computat Biol, College Pk, MD 20742 USA.
[Miotto, Olivo; Campino, Susana; Macinnis, Bronwyn; Kwiatkowski, Dominic P.] Univ Oxford, Med Res Council Ctr Genom & Global Hlth, Oxford OX3 7BN, England.
[Miotto, Olivo; Dondorp, Arjen M.; Nosten, Francois; Phyo, Aung Pyae; White, Nicholas J.] Mahidol Univ, Fac Trop Med, Mahidol Oxford Res Unit, Bangkok 10400, Thailand.
[Fukuda, Mark M.; Bethell, Delia; Tyner, Stuart D.; Saunders, David L.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Nosten, Francois; Phyo, Aung Pyae] Shoklo Malaria Res Unit, Mae Sot 63110, Tak, Thailand.
[Noedl, Harald; Starzengruber, Peter; Fuehrer, Hans-Peter; Swoboda, Paul] Med Univ Vienna, Inst Specif Prophylaxis & Trop Med, A-1090 Vienna, Austria.
[Imwong, Mallika] Mahidol Univ, Fac Trop Med, Dept Mol Trop Med & Genet, Bangkok 10400, Thailand.
[Se, Youry; Lon, Chanthap] Armed Forces Res Inst Med Sci, Phnom Penh 12252, Cambodia.
[Socheat, Duong] Univ Hlth Sci, Phnom Penh 12201, Cambodia.
[Ariey, Frederic] Inst Pasteur, Unite Immunol Mol Parasites, F-75015 Paris, France.
[Stepniewska, Kasia; Flegg, Jennifer] Univ Oxford, WorldWide Antimalarial Resistance Network, Oxford OX3 7LJ, England.
[Arze, Cesar; Cerqueira, Gustavo C.; Silva, Joana C.] Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA.
[Ricklefs, Stacy M.; Porcella, Stephen F.] NIAID, Res Technol Branch, Rocky Mt Labs, NIH, Hamilton, MT 59840 USA.
[Stephens, Robert M.] Adv Biomed Comp Ctr, Frederick, MD 21702 USA.
[Campino, Susana; Auburn, Sarah; Macinnis, Bronwyn; Kwiatkowski, Dominic P.] Wellcome Trust Sanger Inst, Malaria Programme, Hinxton CB10 1SA, England.
[Su, Xin-zhuan] NIAID, Lab Malaria & Vector Res, NIH, Bethesda, MD 20892 USA.
[Ringwald, Pascal] CERN, Drug Resistance & Containment Unit, Global Malaria Programme, CH-1211 Geneva 27, Switzerland.
RP Plowe, CV (reprint author), Univ Maryland, Sch Med, Howard Hughes Med Inst, Ctr Vaccine Dev, Baltimore, MD 21201 USA.
EM cplowe@medicine.umaryland.edu
RI Valle, Ruben/A-7512-2013; Ward, Steve/G-6003-2015;
OI Ward, Steve/0000-0003-2331-3192; Auburn, Sarah/0000-0002-4638-536X;
Kwiatkowski, Dominic/0000-0002-5023-0176; Pyae Phyo,
Aung/0000-0002-0383-9624
FU Bill and Melinda Gates Foundation; Howard Hughes Medical Institute;
Doris Duke Charitable Foundation; Division of Intramural Research,
National Institute for Allergy and Infectious Diseases; National
Institutes of Health (NIH) [IH K12RR023250]; National Cancer Institute
and NIH [HHSN261200800001E]; Centre for Genomics and Global Health by
the Medical Research Council [G19/9, G0600230, G0600718]; Wellcome Trust
[077012/Z/05/Z, 098051]; Resource Centre for Genomic Epidemiology of
Malaria [090770/Z/09/Z]
FX This work was supported by the Bill and Melinda Gates Foundation; the
Howard Hughes Medical Institute; the Doris Duke Charitable Foundation;
the Division of Intramural Research, National Institute for Allergy and
Infectious Diseases; National Institutes of Health (NIH) Grant IH
K12RR023250 (to S. T.-H.); National Cancer Institute and NIH Contract
HHSN261200800001E (to R. M. S.); and Centre for Genomics and Global
Health by the Medical Research Council Grants G19/9, G0600230, and
G0600718 (to D. P. K. and O.M.). The Wellcome Trust provides core
support to the Wellcome Trust Sanger Institute under Contract
077012/Z/05/Z, 098051, and the Resource Centre for Genomic Epidemiology
of Malaria Contract 090770/Z/09/Z.
NR 34
TC 126
Z9 127
U1 1
U2 50
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD JAN 2
PY 2013
VL 110
IS 1
BP 240
EP 245
DI 10.1073/pnas.1211205110
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 071XI
UT WOS:000313630300057
PM 23248304
ER
PT S
AU Hsieh, B
Ratcliff, J
AF Hsieh, Bernard
Ratcliff, Jay
BE Iliadis, L
Papadopoulos, H
Jayne, C
TI Coastal Hurricane Inundation Prediction for Emergency Response Using
Artificial Neural Networks
SO ENGINEERING APPLICATIONS OF NEURAL NETWORKS, EANN 2013, PT I
SE Communications in Computer and Information Science
LA English
DT Proceedings Paper
CT 14th International Conference on Engineering Applications of Neural
Networks (EANN)
CY SEP 13-16, 2013
CL Halkidiki, GREECE
DE Storm Surge Prediction; surrogate modeling; neural networks; multilayer
perceptron
ID TERM STORM-SURGE
AB Emergency managers require both fast and accurate estimates of hurricane inundation to make critical decisions about evacuations, structure closures, and other emergency response activities before, during, and after events. Probability analyses require multiple simulations which, generally, cannot be performed with the physics-based models under the time constraints during emergency conditions. To obtain highly accurate results with a fast turnaround computation time a "surrogate" modeling approach is employed. This surrogate modeling approach uses an extensive database of storms and storm responses and applies "smart" pattern recognition tools such as Artificial Neural Networks (ANN) as well as interpolation techniques. The goal is to provide forecasts of hurricane inundation and waves with the accuracy of high-resolution, high-fidelity models but with very short execution time (minutes). The city of New Orleans as well as surrounding municipalities along the Gulf of Mexico coastal area encompasses the region used to demonstrate this approach. The results indicate that the developed surge prediction tool could be used to forecast both magnitude and duration to peak surge for multiple selected points in a few minutes of computational time once the storm parameters are provided. In this paper, only results of surge magnitude are presented.
C1 [Hsieh, Bernard; Ratcliff, Jay] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Hsieh, B (reprint author), US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
EM hsiehb@wes.army.mil
NR 9
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 1865-0929
BN 978-3-642-41012-3; 978-3-642-41013-0
J9 COMM COM INF SC
PY 2013
VL 383
BP 102
EP 111
PG 10
WC Computer Science, Artificial Intelligence; Computer Science, Information
Systems; Computer Science, Theory & Methods
SC Computer Science
GA BB7CI
UT WOS:000345333800011
ER
PT B
AU Palmer-Moloney, LJ
AF Palmer-Moloney, Laura Jean
BE Weinthal, E
Troell, J
Nakayama, M
TI Water's role in measuring security and stability in Helmand Province,
Afghanistan
SO WATER AND POST-CONFLICT PEACEBUILDING
LA English
DT Article; Book Chapter
C1 [Palmer-Moloney, Laura Jean] US Army Corps Engineers, Engineer Res & Dev Ctr, Alexandria, VA 22315 USA.
RP Palmer-Moloney, LJ (reprint author), US Army Corps Engineers, Engineer Res & Dev Ctr, Alexandria, VA 22315 USA.
NR 47
TC 0
Z9 0
U1 0
U2 0
PU ROUTLEDGE
PI LONDON
PA 11 NEW FETTER LANE, LONDON EC4P 4EE, ENGLAND
BN 978-1-84971-232-3; 978-1-84977-580-9
PY 2013
BP 211
EP 235
PG 25
WC Environmental Studies; International Relations; Planning & Development
SC Environmental Sciences & Ecology; International Relations; Public
Administration
GA BB5TI
UT WOS:000344088700015
ER
PT B
AU Dehgan, A
Palmer-Moloney, LJ
Mirzaee, M
AF Dehgan, Alex
Palmer-Moloney, Laura Jean
Mirzaee, Mehdi
BE Weinthal, E
Troell, J
Nakayama, M
TI Water security and scarcity: Potential destabilization in western
Afghanistan and Iranian Sistan and Baluchestan due to transboundary
water conflicts
SO WATER AND POST-CONFLICT PEACEBUILDING
LA English
DT Article; Book Chapter
C1 [Dehgan, Alex] US Agcy Int Dev, Washington, DC 20523 USA.
[Palmer-Moloney, Laura Jean] US Army Corps Engineers, Engineer Res & Dev Ctr, Washington, DC USA.
[Mirzaee, Mehdi] Islamic Azad Univ, Cent Tehran Branch, Tehran, Iran.
[Mirzaee, Mehdi] Oregon State Univ, Dept Geosci, Ctr Water Conflict Management, Corvallis, OR 97331 USA.
RP Dehgan, A (reprint author), US Agcy Int Dev, Washington, DC 20523 USA.
NR 63
TC 1
Z9 1
U1 0
U2 0
PU ROUTLEDGE
PI LONDON
PA 11 NEW FETTER LANE, LONDON EC4P 4EE, ENGLAND
BN 978-1-84971-232-3; 978-1-84977-580-9
PY 2013
BP 305
EP 326
PG 22
WC Environmental Studies; International Relations; Planning & Development
SC Environmental Sciences & Ecology; International Relations; Public
Administration
GA BB5TI
UT WOS:000344088700021
ER
PT B
AU Lambert, B
Miller, C
Ogard, L
Ritchey, B
AF Lambert, Bruce
Miller, Chad
Ogard, Libby
Ritchey, Ben
BE Bergqvist, R
Wilmsmeier, G
Cullinane, K
TI Observations on the Potential for Dry Port Terminal Developments in the
United States
SO DRY PORTS - A GLOBAL PERSPECTIVE: CHALLENGES AND DEVELOPMENTS IN SERVING
HINTERLANDS
SE Transport and Society
LA English
DT Article; Book Chapter
C1 [Lambert, Bruce] Inst Trade & Transportat Studies, New Orleans, LA 70130 USA.
[Lambert, Bruce] US Army Corps Engineers, Inst Water Resources, Washington, DC USA.
[Lambert, Bruce] Int Nav Assoc PIANC, US Sect, Alexandria, VA USA.
[Lambert, Bruce] Fed Highway Adm, Washington, DC USA.
[Lambert, Bruce] Louisiana State Univ, Baton Rouge, LA 70803 USA.
[Miller, Chad] Univ So Mississippi, Dept Econ & Workforce Dev, Hattiesburg, MS 39406 USA.
[Ogard, Libby] Prime Focus LLC, De Pere, WI USA.
[Ogard, Libby] Prime Focus LLC, Retail Div, De Pere, WI USA.
[Ritchey, Ben] US DOT, Washington, DC USA.
[Ritchey, Ben] US DOE, Washington, DC 20585 USA.
RP Lambert, B (reprint author), Inst Trade & Transportat Studies, New Orleans, LA 70130 USA.
NR 25
TC 0
Z9 0
U1 0
U2 0
PU ASHGATE PUBLISHING LTD
PI ALDERSHOT
PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND
BN 978-1-4094-4425-1; 978-1-4094-4424-4
J9 TRANSP SOC
PY 2013
BP 173
EP 195
PG 23
WC Transportation
SC Transportation
GA BB4WP
UT WOS:000343418900010
ER
PT B
AU Monios, J
Lambert, B
AF Monios, Jason
Lambert, Bruce
BE Bergqvist, R
Wilmsmeier, G
Cullinane, K
TI Intermodal Freight Corridor Development in The United States
SO DRY PORTS - A GLOBAL PERSPECTIVE: CHALLENGES AND DEVELOPMENTS IN SERVING
HINTERLANDS
SE Transport and Society
LA English
DT Article; Book Chapter
ID PORT COMPETITION
C1 [Monios, Jason] Edinburgh Napier Univ, TRI, Edinburgh, Midlothian, Scotland.
[Lambert, Bruce] US Army Corps Engineers, Inst Water Resources, Washington, DC USA.
[Lambert, Bruce] Int Nav Assoc PIANC, US Sect, Brussels, Belgium.
[Lambert, Bruce] Fed Highway Adm, Washington, DC USA.
[Lambert, Bruce] IHS Global Insight, Port Long Beach, Long Beach, CA USA.
[Lambert, Bruce] Louisiana State Univ, Baton Rouge, LA 70803 USA.
RP Monios, J (reprint author), Edinburgh Napier Univ, TRI, Edinburgh, Midlothian, Scotland.
NR 23
TC 2
Z9 2
U1 1
U2 1
PU ASHGATE PUBLISHING LTD
PI ALDERSHOT
PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND
BN 978-1-4094-4425-1; 978-1-4094-4424-4
J9 TRANSP SOC
PY 2013
BP 197
EP 218
PG 22
WC Transportation
SC Transportation
GA BB4WP
UT WOS:000343418900011
ER
PT S
AU Yu, JJ
Cali, J
Zhao, F
Dai, FF
Jin, X
Pukish, M
Jin, YH
Hubbard, Z
Irwin, JD
Jaeger, RC
Aklian, A
AF Yu, Jianjun
Cali, Joseph
Zhao, Feng
Dai, Fa Foster
Jin, Xin
Pukish, Michael
Jin, Yuehai
Hubbard, Zachary
Irwin, J. David
Jaeger, Richard C.
Aklian, Andre
GP IEEE
TI A Direct Digital Synthesis Based Chirp Radar Transmitter in 0.13 mu m
SiGe Technology
SO 2013 IEEE BIPOLAR/BICMOS CIRCUITS AND TECHNOLOGY MEETING (BCTM)
SE IEEE Bipolar BiCMOS Circuits and Technology Meeting
LA English
DT Proceedings Paper
CT IEEE Bipolar/BiCMOS Circuits and Technology Meeting (BCTM)
CY SEP 30-OCT 03, 2013
CL Bordeaux, FRANCE
SP IEEE, Analog Devices, IBM, Maxim, NXP, RFMD, Tektronix, Anadigics, Microsemi, Skyworks, Texas Instruments
DE Direct digital synthesis (DDS); Chirp; FMCW; Radar; Transmitter
ID CMOS TRANSCEIVER; FMCW RADAR
AB This paper presents an X-band direct digital synthesis (DDS) based chirp radar transmitter implemented in 0.13 mu m SiGe BiCMOS technology. The transmitter contains a quadrature DDS, two low-pass filters, an IF IQ modulator, a programmable gain amplifier (PGA), a RF mixer and a pre-amplifier. The DDSs, built with two digital-to-analog converters (DACs), generate two-channel IQ baseband chirp signals from 62MHz to 77MHz. The IQ chirp signals are filtered by two programmable 5th-order Butterworth filters before up-converted to the IF frequency with IQ modulators. The filtered IF signal is further up-converted to the desired radio frequency by an RF mixer. The proposed transmitter thus generates a chirp signal at 8.6GHz, consuming a total power of 333 mW from 2.2V and 1.5V power supplies.
C1 [Yu, Jianjun; Cali, Joseph; Zhao, Feng; Dai, Fa Foster; Jin, Xin; Pukish, Michael; Jin, Yuehai; Hubbard, Zachary; Irwin, J. David; Jaeger, Richard C.] Auburn Univ, Dept Elect & Comp Engn, Auburn, AL 36849 USA.
[Aklian, Andre] US Army Res, RDECOM CERDEC Intelligence & Informat, Los Angeles, CA USA.
RP Yu, JJ (reprint author), Auburn Univ, Dept Elect & Comp Engn, Auburn, AL 36849 USA.
NR 8
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1088-9299
BN 978-1-4799-0129-6
J9 IEEE BIPOL BICMOS
PY 2013
BP 41
EP 44
PG 4
WC Engineering, Electrical & Electronic
SC Engineering
GA BB3AW
UT WOS:000342622100010
ER
PT J
AU Melby, JA
Nadal, NC
Males, RM
AF Melby, Jeffrey A.
Nadal, Norberto C.
Males, Richard M.
BE Takahashi, S
Kobayashi, N
Shimosako, KI
TI CSsim: BREAKWATER-HARBOR TIME-DEPENDENT LIFE-CYCLE ANALYSIS SOFTWARE
SO COASTAL STRUCTURES 2011, VOL 1 & 2
LA English
DT Proceedings Paper
CT 6th International Conference on Coastal Structures
CY SEP 06-08, 2011
CL Yokohama, JAPAN
SP ASCE COPRI, Kajima Fdn
ID WAVE RUNUP
AB Time-dependent life-cycle analysis of breakwater projects is addressed in new software CSsim. The system provides tools for risk assessments of breakwater/harbor projects. Recent innovations within this system include improvements to the time-dependent breakwater profile evolution, in-stream computation of wave diffraction, and consequence analysis. Companion software called StormSim provides tools for extremal probabilistic analysis of storm parameters and simulation of future wave, wind, and water level storm life cycles. StormSim simulation strategy employs a traditional Monte Carlo simulation of future offshore storm life cycles based on repeated sampling from joint probability distributions. The modeled storm characteristics include typical wave and water level parameters, storm hydrograph, relative phasing between parameters, tidal influences, and storm time-of-year. Climate change issues are addressed. Storm wave life cycles are transformed to nearshore using a table lookup. The historical and simulated nearshore wave and water level time series are used within CSsim to determine structure damage and wave transmission for a traditional multilayer rubble mound breakwater using innovative time-dependent process modeling. Wave transmission into the bay is computed for historical and simulated storm time series. The consequences, such as downtime for the harbor or channel and damage to infrastructure, are determined for breakwater repair alternatives. The probabilities of exceeding damage limit states are also computed. The method provides a basis for selecting the least-cost alternative for rehabilitation or new construction.
C1 [Melby, Jeffrey A.; Nadal, Norberto C.] US Army Engineer R&D Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA.
[Males, Richard M.] RMM Tech Serv, Cincinnati, OH USA.
RP Melby, JA (reprint author), US Army Engineer R&D Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA.
NR 8
TC 0
Z9 0
U1 1
U2 2
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE
BN 978-981-4412-20-9
PY 2013
BP 649
EP 658
PG 10
WC Engineering, Civil; Water Resources
SC Engineering; Water Resources
GA BB2TO
UT WOS:000342302100056
ER
PT J
AU Arp, R
Decker, KS
AF Arp, Robert
Decker, Kevin S.
BE Arp, R
Decker, KS
TI "Well, I'm Afraid It's About to Happen Again" Introducing The Ultimate
South Park and Philosophy Introduction
SO ULTIMATE SOUTH PARK AND PHILOSOPHY: RESPECT MY PHILOSOPHAH!
SE Blackwell Philosophy and Pop Culture Series
LA English
DT Editorial Material; Book Chapter
C1 [Arp, Robert] US Army, Washington, DC 20301 USA.
[Decker, Kevin S.] Eastern Washington Univ, Philosophy Program, Spokane, WA USA.
RP Arp, R (reprint author), US Army, Washington, DC 20301 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA
BN 978-1-118-38656-9
J9 BLACKWELL PHILOS POP
PY 2013
BP 1
EP 4
D2 10.1002/9781118607442
PG 4
WC Philosophy
SC Philosophy
GA BB2OI
UT WOS:000341973000001
ER
PT J
AU Arp, R
AF Arp, Robert
BE Arp, R
Decker, KS
TI Dude, Listen to Reason! Logic Lessons Inside and Outside South Park
SO ULTIMATE SOUTH PARK AND PHILOSOPHY: RESPECT MY PHILOSOPHAH!
SE Blackwell Philosophy and Pop Culture Series
LA English
DT Article; Book Chapter
C1 US Army, Washington, DC 20301 USA.
RP Arp, R (reprint author), US Army, Washington, DC 20301 USA.
NR 4
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA
BN 978-1-118-38656-9
J9 BLACKWELL PHILOS POP
PY 2013
BP 41
EP 52
D2 10.1002/9781118607442
PG 12
WC Philosophy
SC Philosophy
GA BB2OI
UT WOS:000341973000005
ER
PT B
AU Bradbury-Huang, H
Long, K
AF Bradbury-Huang, Hilary
Long, Ken
BE Stevenson, RB
Brody, M
Dillon, J
Wals, AEJ
TI Collaborative Ecological Inquiry Where Action Research Meets Sustainable
Development
SO INTERNATIONAL HANDBOOK OF RESEARCH ON ENVIRONMENTAL EDUCATION
LA English
DT Article; Book Chapter
C1 [Bradbury-Huang, Hilary] Oregon Hlth & Sci Univ, Portland, OR 97201 USA.
[Long, Ken] US Army Command, Ft Bragg, NC USA.
[Long, Ken] Gen Staff Coll, Leavenworth, KS USA.
RP Bradbury-Huang, H (reprint author), Oregon Hlth & Sci Univ, Portland, OR 97201 USA.
NR 46
TC 0
Z9 0
U1 0
U2 1
PU ROUTLEDGE
PI LONDON
PA 11 NEW FETTER LANE, LONDON EC4P 4EE, ENGLAND
BN 978-0-415-89239-1; 978-0-203-81333-1; 978-0-415-89238-4
PY 2013
BP 459
EP 468
PG 10
WC Education & Educational Research; Environmental Studies
SC Education & Educational Research; Environmental Sciences & Ecology
GA BB1TF
UT WOS:000341355100051
ER
PT J
AU Sensoy, M
de Mel, G
Kaplan, L
Pham, T
Norman, TJ
AF Sensoy, Murat
de Mel, Geeth
Kaplan, Lance
Tien Pham
Norman, Timothy J.
GP IEEE
TI TRIBE: Trust Revision for Information Based on Evidence
SO 2013 16TH INTERNATIONAL CONFERENCE ON INFORMATION FUSION (FUSION)
LA English
DT Proceedings Paper
CT 16th International Conference on Information Fusion (FUSION)
CY JUL 09-12, 2013
CL Istanbul, TURKEY
SP HAVELSAN, METEKSAN SAVUNMA, TUBITAK, METRON Sci Solut, Off Naval Res Global Sci & Technol, Ankara Univ, Sabanci Univ, STM, TAI, ASELSAN, Koc Bilgi Savunma Teknolojileri A S, Kale Havacilik, Int Soc Infromat Fus, IEEE, AESS
DE Information Fusion; Trust; Constraint Optimisation; Subjective Logic;
Dempster-Shafer Theory of Evidence
ID REPUTATION
AB In recent years, the number of information sources available to support decision-making has increased dramatically. However, more information sources do not always mean higher precision in the fused information. This is partially due to the fact that some of these sources may be erroneous or malicious. Therefore, it is critical to asses the trust in information before performing fusion. To estimate trust in information, existing approaches use trustworthiness of its source as a proxy. We argue that conflicts between information may also serve as evidence to reduce trust in information. In this paper, we use subjective opinions to represent information from diverse sources. We propose to exploit conflicts between opinions to revise their trustworthiness. For this purpose, we formalise trust revision as a constraint optimisation problem. Through extensive empirical studies, we show that our approach significantly outperform existing ones in the face of malicious information sources.
C1 [Sensoy, Murat] Ozyegin Univ, Dept Comp Sci, Istanbul, Turkey.
[Sensoy, Murat; Norman, Timothy J.] Univ Aberdeen, Dept Comp Sci, Aberdeen AB9 1FX, Scotland.
[de Mel, Geeth; Kaplan, Lance; Tien Pham] US Army, Res Lab, Adelphi, MD 20783 USA.
[de Mel, Geeth] IBM TJ Watson Res Ctr, Hawthorne, NY USA.
RP Sensoy, M (reprint author), Ozyegin Univ, Dept Comp Sci, Istanbul, Turkey.
FU U.S. Army Research Laboratory; U.K. Ministry of Defence
[W911NF-06-3-0001]; The Scientific and Technological Research Council of
Turkey (TUBITAK) [111K476]
FX Research was sponsored by the U.S. Army Research Laboratory and the U.K.
Ministry of Defence and was accomplished under Agreement Number
W911NF-06-3-0001. The views and conclusions contained in this document
are those of the author(s) and should not be interpreted as representing
the official policies, either expressed or implied, of the U.S. Army
Research Laboratory, the U.S. Government, the U.K. Ministry of Defence
or the U.K. Government. The U.S. and U.K. Governments are authorised to
reproduce and distribute reprints for Government purposes
notwithstanding any copyright notation hereon. Dr. Sensoy thanks to The
Scientific and Technological Research Council of Turkey (TUBITAK) for
its support under grant 111K476.
NR 15
TC 4
Z9 4
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-605-86311-1-3
PY 2013
BP 914
EP 921
PG 8
WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic
SC Computer Science; Engineering
GA BB1UM
UT WOS:000341370000122
ER
PT J
AU Damarla, T
Kaplan, LM
AF Damarla, Thyagaraju
Kaplan, Lance M.
GP IEEE
TI A Fusion Architecture for Tracking a Group of People using a Distributed
Sensor Network
SO 2013 16TH INTERNATIONAL CONFERENCE ON INFORMATION FUSION (FUSION)
LA English
DT Proceedings Paper
CT 16th International Conference on Information Fusion (FUSION)
CY JUL 09-12, 2013
CL Istanbul, TURKEY
SP HAVELSAN, METEKSAN SAVUNMA, TUBITAK, METRON Sci Solut, Off Naval Res Global Sci & Technol, Ankara Univ, Sabanci Univ, STM, TAI, ASELSAN, Koc Bilgi Savunma Teknolojileri A S, Kale Havacilik, Int Soc Infromat Fus, IEEE, AESS
DE Personnel detection; decentralized fusion; tracking; non-negative matrix
factorization; classification; basis vectors
ID NONNEGATIVE MATRIX FACTORIZATION; SYSTEMS
AB This paper presents an architecture to fuse the information from different spatially distributed unattended ground sensors (UGSs) consisting of multiple modalities to track a group of people walking along trails in open areas. The UGS system we used consists of ultrasonic, seismic and passive infrared (PIR) sensors. Estimating the size of the group is done by counting the number of targets using ultrasonic sensors. Determining the composition of the group is done using several classifiers. The fusion is done at the UGS level to fuse information from all the modalities to determine the presence of a target(s) and the information from multiple UGS systems are fused to track a group. The algorithms are tested on data collected in the wilderness with three UGS systems separated 75 m apart on a trail.
C1 [Damarla, Thyagaraju; Kaplan, Lance M.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Damarla, T (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
EM thyagaraju.damarla.civ@mail.mil; lance.m.kaplan.civ@mail.mil
NR 12
TC 0
Z9 0
U1 0
U2 3
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-605-86311-1-3
PY 2013
BP 1776
EP 1783
PG 8
WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic
SC Computer Science; Engineering
GA BB1UM
UT WOS:000341370000236
ER
PT J
AU Kaplan, LM
Sensoy, M
Tang, YQ
Chakraborty, S
Bisdikian, C
de Mel, G
AF Kaplan, Lance M.
Sensoy, Murat
Tang, Yuqing
Chakraborty, Supriyo
Bisdikian, Chatschik
de Mel, Geeth
GP IEEE
TI Reasoning Under Uncertainty: Variations of Subjective Logic Deduction
SO 2013 16TH INTERNATIONAL CONFERENCE ON INFORMATION FUSION (FUSION)
LA English
DT Proceedings Paper
CT 16th International Conference on Information Fusion (FUSION)
CY JUL 09-12, 2013
CL Istanbul, TURKEY
SP HAVELSAN, METEKSAN SAVUNMA, TUBITAK, METRON Sci Solut, Off Naval Res Global Sci & Technol, Ankara Univ, Sabanci Univ, STM, TAI, ASELSAN, Koc Bilgi Savunma Teknolojileri A S, Kale Havacilik, Int Soc Infromat Fus, IEEE, AESS
AB This work develops alternatives to the classical subjective logic deduction operator. Given antecedent and consequent propositions, the new operators form opinions of the consequent that match the variance of the consequent posterior distribution given opinions on the antecedent and the conditional rules connecting the antecedent with the consequent. As a result, the uncertainty of the consequent actually map to the spread for the probability projection of the opinion. Monte Carlo simulations demonstrate this connection for the new operators. Finally, the work uses Monte Carlo simulations to evaluate the quality of fusing opinions from multiple agents before and after deduction.
C1 [Kaplan, Lance M.; de Mel, Geeth] US Army Res Lab, Adelphi, MD 20783 USA.
[Sensoy, Murat] Ozyegin Univ, Istanbul, Turkey.
[Sensoy, Murat] Univ Aberdeen, Aberdeen AB9 1FX, Scotland.
[Tang, Yuqing] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA.
[Chakraborty, Supriyo] Univ Calif Los Angeles, Los Angeles, CA 90024 USA.
[Bisdikian, Chatschik; de Mel, Geeth] IBM Res, T J Watson Res Ctr, Yorktown Hts, NY USA.
RP Kaplan, LM (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
FU U.S. Army Research Laboratory; U.K Ministry of Defense
FX Research was sponsored by the U.S. Army Research Laboratory and the U.K
Ministry of Defense and was accomplished under Agreement Number
W911NF-06-3-0001. The views and conclusions contained in this document
are those of the authors and should not be interpreted as repr esenting
the official policies, either expressed or implied, of the U.S Ar my
Research Laboratory, the U.S. Government, the U.K. Ministry of Defen se
or the U.K Government. The U.S. and U.K. Governments are authorized to
reproduce and distribute for Government purposes notwithstanding any co
pyright notation hereon.
NR 12
TC 1
Z9 1
U1 0
U2 4
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-605-86311-1-3
PY 2013
BP 1910
EP 1917
PG 8
WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic
SC Computer Science; Engineering
GA BB1UM
UT WOS:000341370000254
ER
PT S
AU Cohn, MB
Saechao, K
Whitlock, M
Brenman, D
Tang, WT
Proie, RM
AF Cohn, Michael B.
Saechao, Kaosio
Whitlock, Michael
Brenman, Daniel
Tang, Wallace T.
Proie, Robert M., Jr.
GP IEEE
TI RF MEMS Switches for Wide I/O Data Bus Applications
SO 2013 IEEE INTERNATIONAL TEST CONFERENCE (ITC)
SE International Test Conference Proceedings
LA English
DT Proceedings Paper
CT IEEE International Test Conference (ITC)
CY SEP 10-12, 2013
CL Anaheim, CA
SP IEEE Comp Soc, Test Technol Tech Council, IEEE Philadelphia Sect
DE TSV; Wide I/O; MEMS Switch; ATE; Switch Matrix; Relay
AB Wide I/O poses serious challenges due to the requisite high density of electronics and relays near the DUT, as well as high bandwidth. A 2x2mm MEMS switch has been demonstrated, offering >80% footprint reduction relative to a typical TO-can electromagnetic relay. A further benefit of its small size, the MEMS relay is able to operate up to Ka-band (40 GHz) with hot switch capability and repeatability of <+/- 50mn Omega. To our knowledge, our latest SPDT device holds the current record in power handling for MEMS devices of 24 W at 10 million cycles.
C1 [Cohn, Michael B.; Saechao, Kaosio; Whitlock, Michael; Brenman, Daniel; Tang, Wallace T.] MicroAssembly Technol Inc, 934 Marina Way South, Richmond, CA 94804 USA.
[Proie, Robert M., Jr.] Army Res Lab, Adelphi, MD 20783 USA.
RP Cohn, MB (reprint author), MicroAssembly Technol Inc, 934 Marina Way South, Richmond, CA 94804 USA.
EM mbc@microassembly.com; ksc@microassembly.com; mwk@microassembly.com;
dh@microassembly.com; wallacet@microassembly.com;
robert.m.proie.civ@mail.mil
FU U.S. Army [W911QX-07-C-0081]; U.S. Air Force [FA9453-07-D-0173];
STLE/ASME International Joint Tribology Conference, San Diego, CA
[CD-ROM IJTC2007-44265]
FX The switch and switch matrix development work has been supported by
funding from the U.S. Army (Contract #: W911QX-07-C-0081) and U.S. Air
Force (Contract #: FA9453-07-D-0173). Electrically steered antenna work
has been supported by funding from the U.S. Army (Contract #:
W911QX-07-C-0091) and U.S. Air Force (Contract #: FA8650-09-C-1600)
STLE/ASME International Joint Tribology Conference, San Diego, CA,
CD-ROM IJTC2007-44265 (2007).
NR 4
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1089-3539
BN 978-1-4799-0859-2
J9 INT TEST CONF P
PY 2013
PG 8
WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic
SC Computer Science; Engineering
GA BB1UQ
UT WOS:000341376000014
ER
PT J
AU Jones, DE
Hammond, P
Platoni, K
AF Jones, David E.
Hammond, Patricia
Platoni, Kathy
TI Traumatic Event Management in Afghanistan: A Field Report on Combat
Applications in Regional Command-South
SO MILITARY MEDICINE
LA English
DT Editorial Material
AB This article provides information on the use of Traumatic Event Management (TEM) strategies to debrief combat arms personnel whose units sustained traumatic losses in Afghanistan. The specific focus is on the application of Event-Driven Battlemind Psychological Debriefings to combat units. This article offers the first published account of TEM services employed in southern Afghanistan during intensive surge operations in 2009-2010. This article unfolds in three parts: (1) background to the region in which the debriefings occurred; (2) three case examples with a data summary of types of incidents observed; and (3) discussion of observations, lessons learned, and recommendations for training future clinicians to provide effective debriefings to combat arms personnel.
C1 [Jones, David E.] Naval Med Ctr Portsmouth, Portsmouth, VA 23708 USA.
[Hammond, Patricia] US Army, John F Kennedy Special Warfare Ctr & Sch, ATTN AOJK GRP, Stop Ft Bragg, NC 28310 USA.
[Platoni, Kathy] Armed Forces Reserve Ctr, Madison, WI 53704 USA.
RP Jones, DE (reprint author), Naval Med Ctr Portsmouth, 620 John Paul Jones Circle, Portsmouth, VA 23708 USA.
NR 10
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JAN
PY 2013
VL 178
IS 1
BP 4
EP 10
DI 10.7205/MILMED-D-12-00070
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7TV
UT WOS:000340804800006
PM 23356111
ER
PT J
AU Walsh, R
Heiner, J
Kang, C
Hile, D
Deering, S
AF Walsh, Ryan
Heiner, Jason
Kang, Christopher
Hile, David
Deering, Shad
TI Emergency Physician Evaluation of a Novel Surgical Cricothyroidotomy
Tool in Simulated Combat and Clinical Environments
SO MILITARY MEDICINE
LA English
DT Article
ID MEDICINE; MINIMUM; SKILLS
AB We sought to investigate the performance of a novel cricothyroidotomy CRIC device compared to the traditional surgical in both simulated combat environments and the emergency department (ED) setting. Twenty U.S. Army staff and resident emergency medicine physicians were randomized to device and simulated setting order and performed cricothyroidotomies in the standard manner and with the CRIC device via the Trauma Man surgical simulator in three simulated settings: the ED, a day. combat environment, and a night combat environment. Differences in procedural completion for the two methods in different settings were compared by two-tailed paired t-tests. The occurrence of major and minor procedural complications and questions presented as 5-point Likert scales to describe participants' preferences of cricothyroidotomy methods were compared by chi(2) analysis. Time to incision, time to procedural completion, and rate of major and minor complications were not significantly different between the standard surgical method and the CRIC device (p > 0.05). In the simulated ED setting, 60% of participants preferred the standard surgical method (95% confidence interval: 38.5-81.5), whereas in the simulated combat settings, 50% of participants preferred each device (95% confidence interval: 28.1-71.9). In our population, we observed similar operator performance characteristics and physician preferences between the 2 methods in all simulated cricothyroidotomy settings.
C1 [Walsh, Ryan; Kang, Christopher; Hile, David; Deering, Shad] Madigan Army Med Ctr, Tacoma, WA 98431 USA.
[Heiner, Jason] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
[Heiner, Jason] Univ Washington, Div Emergency Med, Seattle, WA 98105 USA.
RP Walsh, R (reprint author), Madigan Army Med Ctr, 9040 Fitzsimmons Dr, Tacoma, WA 98431 USA.
NR 19
TC 1
Z9 1
U1 0
U2 1
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JAN
PY 2013
VL 178
IS 1
BP 29
EP 33
DI 10.7205/MILMED-D-12-00266
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7TV
UT WOS:000340804800010
PM 23356115
ER
PT J
AU Westhoff, JL
Roberts, BJ
Erickson, K
AF Westhoff, John L.
Roberts, Brad J.
Erickson, Kristin
TI Vehicle-Mounted High-Power Microwave Systems and Health Risk
Communication in a Deployed Environment
SO MILITARY MEDICINE
LA English
DT Article
AB Vehicle-mounted high-power microwave systems have been developed to counter the improvised explosive device threat in southwest Asia. Many service members only vaguely comprehend the nature of these devices and the nonionizing radio frequency (RF) radiation they emit. Misconceptions about the health effects of RIP radiation have the potential to produce unnecessary anxiety. We report an incident in which concern for exposure to radiation from a high-power microwave device thought to be malfunctioning led to an extensive field investigation, multiple evaluations by clinicians in theater, and subsequent referrals to an Occupational Health clinic upon return from deployment. When acute exposure to RF does occur, the effects are thermally mediated and immediately perceptible-limiting the possibility of injury. Unlike ionizing radiation, RF radiation is not known to cause cancer and the adverse health effects are not cumulative. Medical officers counseling service members concerned about potential RIP radiation exposure should apply established principles of risk communication, attend to real and perceived risks, and enlist the assistance of technical experts to properly characterize an exposure when appropriate.
C1 [Westhoff, John L.; Erickson, Kristin] Madigan Healthcare Syst, Dept Prevent Med, Tacoma, WA 98431 USA.
[Roberts, Brad J.] US Army, Publ Hlth Command, Army Inst Publ Hlth, Radio Frequency Program, Aberdeen Proving Ground, MD 21010 USA.
RP Westhoff, JL (reprint author), Madigan Healthcare Syst, Dept Prevent Med, Bldg 9920-A East Johnson St, Tacoma, WA 98431 USA.
NR 8
TC 0
Z9 2
U1 1
U2 4
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JAN
PY 2013
VL 178
IS 1
BP 34
EP 36
DI 10.7205/MILMED-D-12-00134
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7TV
UT WOS:000340804800011
PM 23356116
ER
PT J
AU Shrestha, M
Combest, T
Fonda, SJ
Alfonso, A
Guerrero, A
AF Shrestha, Merica
Combest, Travis
Fonda, Stephanie J.
Alfonso, Abel
Guerrero, Arthur
TI Effect of an Accelerometer on Body Weight and Fitness in Overweight and
Obese Active Duty Soldiers
SO MILITARY MEDICINE
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIAL; PHYSICAL-ACTIVITY; LOSS INTERVENTIONS;
PRIMARY-CARE; INTERNET; PROGRAM; ADULTS
AB This study evaluated whether using a web-linked accelerometer, plus mandatory physical training, is associated with various weight- and fitness-related outcomes in overweight/obese active duty soldiers. Soldiers who failed the height/weight standards of the Army Physical Fitness Test (APFT) were randomized to use a Polar FA20 accelerometer device (polar accelerometer group [PA], n = 15) or usual care (UC, n = 13) for 6 months. Both groups received 1.5 hours of lifestyle instruction. We collected data at baseline, 2, 4, and 6 months, and evaluated group differences in temporal changes in study outcomes. At 6 months, 1/28 subjects (UC) passed the APFT height/weight standards. There were no group differences in changes in weight (PA: -0.1 kg vs. UC: +0.3 kg; p = 0.9), body fat (PA: -0.9% vs. UC: -1.1%; p = 0.9), systolic blood pressure (PA: +1.3 mm Hg vs. UC: -2.1 mm Hg; p = 0.2), diastolic blood pressure (PA: +3.8 mm Hg vs. UC: -2.4 mm Hg; p = 0.3), or resting heart rate in beats per minute (bpm) (PA: +7.8 bpm vs. UC: +0.1 bpm; p = 0.2). These results suggest that using an accelerometer with web-based feedback capabilities plus mandatory physical training does not assist in significant weight loss or ability to pass the APFT height/weight standards among overweight/obese soldiers.
C1 [Shrestha, Merica] Walter Reed Natl Mil Med Ctr, Endocrinol Diabet & Metab Serv, Bethesda, MD 20889 USA.
[Combest, Travis] Walter Reed Natl Mil Med Ctr, Bethesda, MD 20889 USA.
[Fonda, Stephanie J.] Walter Reed Natl Mil Med Ctr, Inst Diabet, Bethesda, MD 20889 USA.
[Alfonso, Abel] Mary Washington Healthcare, Endocrinol & Diabet Associates, Fredericksburg, VA 22401 USA.
[Guerrero, Arthur] Tripler Army Med Ctr, Endocrinol Diabet & Metab Serv, Honolulu, HI 96859 USA.
RP Shrestha, M (reprint author), Walter Reed Natl Mil Med Ctr, Endocrinol Diabet & Metab Serv, 8901 Rockville Pike, Bethesda, MD 20889 USA.
FU Department of Clinical Investigations at the Walter Reed National
Military Medical Center, Bethesda, Maryland
FX Funding was provided by the Department of Clinical Investigations at the
Walter Reed National Military Medical Center, Bethesda, Maryland.
NR 17
TC 6
Z9 6
U1 1
U2 5
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JAN
PY 2013
VL 178
IS 1
BP 82
EP 87
DI 10.7205/MILMED-D-12-00275
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7TV
UT WOS:000340804800019
PM 23356124
ER
PT S
AU Ovelgonne, M
Park, N
Subrahmanian, VS
Bowman, EK
Ogaard, KA
AF Ovelgoenne, Michael
Park, Noseong
Subrahmanian, V. S.
Bowman, Elizabeth K.
Ogaard, Kirk A.
BE Alani, H
Kagal, L
Fokoue, A
Groth, P
Biemann, C
Parreira, JX
Aroyo, L
Noy, N
Welty, C
Janowicz, K
TI Personalized Best Answer Computation in Graph Databases
SO SEMANTIC WEB - ISWC 2013, PART I
SE Lecture Notes in Computer Science
LA English
DT Proceedings Paper
CT 12th International Semantic Web Conference (ISWC)
CY OCT 21-25, 2013
CL Sydney, AUSTRALIA
SP Bing, Fluid Operat, Microsoft Res, PreviousNext, IBM Res, Ontotext, Yahoo, IOS Press, OpenLink Software
ID ALGORITHM; ISOMORPHISM
AB Though subgraph matching has been extensively studied as a query paradigm in semantic web and social network data environments, a user can get a large number of answers in response to a query. Just like Google does, these answers can be shown to the user in accordance with an importance ranking. In this paper, we present scalable algorithms to find the top-K answers to a practically important subset of SPARQL-queries, denoted as importance queries, via a suite of pruning techniques. We test our algorithms on multiple real-world graph data sets, showing that our algorithms are efficient even on networks with up to 6M vertices and 15M edges and far more efficient than popular triple stores.
C1 [Ovelgoenne, Michael; Subrahmanian, V. S.] Univ Maryland, UMIACS, College Pk, MD 20742 USA.
[Park, Noseong; Subrahmanian, V. S.] Univ Maryland, Dept Comp Sci, College Pk, MD 20742 USA.
[Bowman, Elizabeth K.; Ogaard, Kirk A.] US Army Res Lab, Tact Informat Fus Branch, Computat & Informat Sci, Aberdeen Proving Ground, MD USA.
RP Ovelgonne, M (reprint author), Univ Maryland, UMIACS, College Pk, MD 20742 USA.
EM mov@umiacs.umd.edu; npark@umiacs.umd.edu; vs@umiacs.umd.edu;
elizabeth.k.bowman.civ@mail.mil; kirk.a.ogaard.ctr@mail.mil
FU US Army Research Office [W911NF0910206]
FX We thank the anonymous reviewers and Barry Bishop and Nikolay Krustev
from Ontotext for their helpful remarks. Parts of this work have been
funded by the US Army Research Office under grantW911NF0910206.
NR 15
TC 1
Z9 1
U1 0
U2 0
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 0302-9743
BN 978-3-642-41335-3; 978-3-642-41334-6
J9 LECT NOTES COMPUT SC
PY 2013
VL 8218
BP 478
EP 493
PG 16
WC Computer Science, Information Systems; Computer Science, Theory &
Methods
SC Computer Science
GA BB0MD
UT WOS:000340417700030
ER
PT S
AU West, BJ
AF West, Bruce J.
BA West, BJ
BF West, BJ
TI FRACTAL PHYSIOLOGY AND CHAOS IN MEDICINE 2nd Edition Introduction
SO FRACTAL PHYSIOLOGY AND CHAOS IN MEDICINE, 2ND EDITION
SE Studies of Nonlinear Phenomena in Life Science
LA English
DT Editorial Material; Book Chapter
C1 Army Res Off, Ft Bragg, NC 28306 USA.
RP West, BJ (reprint author), Army Res Off, Ft Bragg, NC 28306 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE
SN 1793-1428
BN 978-981-4417-80-8; 978-981-4417-79-2
J9 STUD NONLIN PHENOM
PY 2013
VL 16
BP 1
EP 25
D2 10.1142/8577
PG 25
WC Biology; Mathematics, Interdisciplinary Applications; Medicine, Research
& Experimental
SC Life Sciences & Biomedicine - Other Topics; Mathematics; Research &
Experimental Medicine
GA BA7HA
UT WOS:000337525800002
ER
PT S
AU West, BJ
AF West, Bruce J.
BA West, BJ
BF West, BJ
TI FRACTAL PHYSIOLOGY AND CHAOS IN MEDICINE 2nd Edition Preface
SO FRACTAL PHYSIOLOGY AND CHAOS IN MEDICINE, 2ND EDITION
SE Studies of Nonlinear Phenomena in Life Science
LA English
DT Editorial Material; Book Chapter
C1 Army Res Off, Ft Bragg, NC 28306 USA.
RP West, BJ (reprint author), Army Res Off, Ft Bragg, NC 28306 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE
SN 1793-1428
BN 978-981-4417-80-8; 978-981-4417-79-2
J9 STUD NONLIN PHENOM
PY 2013
VL 16
BP IX
EP +
D2 10.1142/8577
PG 34
WC Biology; Mathematics, Interdisciplinary Applications; Medicine, Research
& Experimental
SC Life Sciences & Biomedicine - Other Topics; Mathematics; Research &
Experimental Medicine
GA BA7HA
UT WOS:000337525800001
ER
PT S
AU West, BJ
AF West, Bruce J.
BA West, BJ
BF West, BJ
TI Physiology in Fractal Dimensions
SO FRACTAL PHYSIOLOGY AND CHAOS IN MEDICINE, 2ND EDITION
SE Studies of Nonlinear Phenomena in Life Science
LA English
DT Article; Book Chapter
C1 Army Res Off, Ft Bragg, NC 28306 USA.
RP West, BJ (reprint author), Army Res Off, Ft Bragg, NC 28306 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE
SN 1793-1428
BN 978-981-4417-80-8; 978-981-4417-79-2
J9 STUD NONLIN PHENOM
PY 2013
VL 16
BP 27
EP 91
D2 10.1142/8577
PG 65
WC Biology; Mathematics, Interdisciplinary Applications; Medicine, Research
& Experimental
SC Life Sciences & Biomedicine - Other Topics; Mathematics; Research &
Experimental Medicine
GA BA7HA
UT WOS:000337525800003
ER
PT S
AU West, BJ
AF West, Bruce J.
BA West, BJ
BF West, BJ
TI Dynamics in Fractal Dimensions
SO FRACTAL PHYSIOLOGY AND CHAOS IN MEDICINE, 2ND EDITION
SE Studies of Nonlinear Phenomena in Life Science
LA English
DT Article; Book Chapter
C1 Army Res Off, Ft Bragg, NC 28306 USA.
RP West, BJ (reprint author), Army Res Off, Ft Bragg, NC 28306 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE
SN 1793-1428
BN 978-981-4417-80-8; 978-981-4417-79-2
J9 STUD NONLIN PHENOM
PY 2013
VL 16
BP 93
EP 176
D2 10.1142/8577
PG 84
WC Biology; Mathematics, Interdisciplinary Applications; Medicine, Research
& Experimental
SC Life Sciences & Biomedicine - Other Topics; Mathematics; Research &
Experimental Medicine
GA BA7HA
UT WOS:000337525800004
ER
PT S
AU West, BJ
AF West, Bruce J.
BA West, BJ
BF West, BJ
TI Statistics in Fractal Dimensions
SO FRACTAL PHYSIOLOGY AND CHAOS IN MEDICINE, 2ND EDITION
SE Studies of Nonlinear Phenomena in Life Science
LA English
DT Article; Book Chapter
C1 Army Res Off, Ft Bragg, NC 28306 USA.
RP West, BJ (reprint author), Army Res Off, Ft Bragg, NC 28306 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE
SN 1793-1428
BN 978-981-4417-80-8; 978-981-4417-79-2
J9 STUD NONLIN PHENOM
PY 2013
VL 16
BP 177
EP 209
D2 10.1142/8577
PG 33
WC Biology; Mathematics, Interdisciplinary Applications; Medicine, Research
& Experimental
SC Life Sciences & Biomedicine - Other Topics; Mathematics; Research &
Experimental Medicine
GA BA7HA
UT WOS:000337525800005
ER
PT S
AU West, BJ
AF West, Bruce J.
BA West, BJ
BF West, BJ
TI Applications of Chaotic Attractors
SO FRACTAL PHYSIOLOGY AND CHAOS IN MEDICINE, 2ND EDITION
SE Studies of Nonlinear Phenomena in Life Science
LA English
DT Article; Book Chapter
C1 Army Res Off, Ft Bragg, NC 28306 USA.
RP West, BJ (reprint author), Army Res Off, Ft Bragg, NC 28306 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE
SN 1793-1428
BN 978-981-4417-80-8; 978-981-4417-79-2
J9 STUD NONLIN PHENOM
PY 2013
VL 16
BP 211
EP 260
D2 10.1142/8577
PG 50
WC Biology; Mathematics, Interdisciplinary Applications; Medicine, Research
& Experimental
SC Life Sciences & Biomedicine - Other Topics; Mathematics; Research &
Experimental Medicine
GA BA7HA
UT WOS:000337525800006
ER
PT S
AU West, BJ
AF West, Bruce J.
BA West, BJ
BF West, BJ
TI Physiological Networks: The Final Chapter?
SO FRACTAL PHYSIOLOGY AND CHAOS IN MEDICINE, 2ND EDITION
SE Studies of Nonlinear Phenomena in Life Science
LA English
DT Article; Book Chapter
C1 Army Res Off, Ft Bragg, NC 28306 USA.
RP West, BJ (reprint author), Army Res Off, Ft Bragg, NC 28306 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE
SN 1793-1428
BN 978-981-4417-80-8; 978-981-4417-79-2
J9 STUD NONLIN PHENOM
PY 2013
VL 16
BP 261
EP 280
D2 10.1142/8577
PG 20
WC Biology; Mathematics, Interdisciplinary Applications; Medicine, Research
& Experimental
SC Life Sciences & Biomedicine - Other Topics; Mathematics; Research &
Experimental Medicine
GA BA7HA
UT WOS:000337525800007
ER
PT J
AU Shiflett, SA
Zinnert, JC
Young, DR
AF Shiflett, Sheri A.
Zinnert, Julie C.
Young, Donald R.
TI Changes in plant community composition and structure following
restoration of maritime communities
SO JOURNAL OF THE TORREY BOTANICAL SOCIETY
LA English
DT Article
DE community; functional groups; maritime communities; ordination;
restoration; structure
ID SEED BANK; SPONTANEOUS SUCCESSION; SECONDARY SUCCESSION; OLD-FIELDS;
VEGETATION; DYNAMICS; FOREST; DIVERSITY; VIRGINIA; ISLAND
AB SHIFLETT, S. A. (Department of Biology, Virginia Commonwealth University, Richmond, VA 23284), J. C. ZINNERT (US Army ERDC Fluorescence Spectroscopy Lab, Alexandria, VA 22315), AND D. R. YOUNG (Department of Biology, Virginia Commonwealth University, Richmond, VA 23284). Changes in plant community composition and structure following restoration of maritime communities. J. Torrey Bot. Soc. 140: 89-100. 2013.-Old field succession has been reviewed extensively in many community settings; however, secondary succession in maritime communities, especially forest and shrub communities is poorly understood. Maritime communities of the North American Atlantic coast are unique and often fragmented ecosystems that provide critical stopover sites for migratory birds. Historical losses coupled with rising developmental pressures have created the need for conservation and restoration to protect these globally rare communities. We examined secondary succession by analyzing the vegetation community composition and soil seed bank of an abandoned agricultural field initially and at seven years (2009) after initiation of state-agency site restoration that used a combination of active and passive restoration techniques. The restoration field was divided into three projected habitats: early maritime forest (16 ha), maritime shrub (12 ha), and coastal grassland (8 ha). A trend was observed with loss of species richness across habitat types. There was a high proportion of species turnover, yet there were no significant differences in the number of species belonging to functional groups for each habitat between the two sampling years (2003 and 2009). Zones where active restoration techniques were used were more indicative of restoration success compared to areas that relied on spontaneous succession. Long-term vegetation surveys are critical to assess the success of restoration operations, and to describe and predict successional trajectories. Accessible vegetation survey data may become increasingly important in the future as land managers place more emphasis on protecting and restoring these overdeveloped, unique coastal communities.
C1 [Shiflett, Sheri A.; Young, Donald R.] Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA.
[Zinnert, Julie C.] US Army ERDC Fluorescence Spect Lab, Alexandria, VA 22315 USA.
RP Zinnert, JC (reprint author), US Army ERDC Fluorescence Spect Lab, Alexandria, VA 22315 USA.
EM jczinner@vcu.edu
FU Adkins Arboretum grant
FX This work was supported partially by an Adkins Arboretum grant to JCZ.
NR 49
TC 1
Z9 1
U1 5
U2 21
PU TORREY BOTANICAL SOC
PI LAWRENCE
PA 810 E 10TH ST, LAWRENCE, KS 66044 USA
SN 1095-5674
EI 1940-0616
J9 J TORREY BOT SOC
JI J. Torrey Bot. Soc.
PD JAN
PY 2013
VL 140
IS 1
BP 89
EP 100
DI 10.3159/TORREY-D-12-00008.1
PG 12
WC Plant Sciences
SC Plant Sciences
GA AM2BY
UT WOS:000339654800009
ER
PT J
AU Vincent, DS
Berg, BW
AF Vincent, Dale S.
Berg, Benjamin W.
BE Arora, R
Arora, P
TI Manikin Simulation for Mass Casualty Incident Training
SO DISASTER MANAGEMENT: MEDICAL PREPAREDNESS, RESPONSE AND HOMELAND
SECURITY
LA English
DT Article; Book Chapter
ID CHEMICAL WARFARE CASUALTIES; PUBLIC-HEALTH PREPAREDNESS; FLORIDA TRAUMA
TRIAGE; MEDICAL-EDUCATION; DISASTER MEDICINE; SKILLS; CARE; TECHNOLOGY;
BOMBINGS; CRITERIA
C1 [Vincent, Dale S.] Tripler Army Med Ctr, Dept Med, MCHK DM, Internal Med Residency Program, Honolulu, HI 96859 USA.
[Berg, Benjamin W.] John A Burns Sch Med, SimTiki Simulat Ctr, Honolulu, HI 96813 USA.
RP Vincent, DS (reprint author), Tripler Army Med Ctr, Dept Med, MCHK DM, Internal Med Residency Program, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
NR 51
TC 0
Z9 0
U1 0
U2 0
PU CABI PUBLISHING-C A B INT
PI WALLINGFORD
PA CABI PUBLISHING, WALLINGFORD 0X10 8DE, OXON, ENGLAND
BN 978-1-84593-929-8
PY 2013
BP 50
EP 64
D2 10.1079/9781845939298.0000
PG 15
WC Health Care Sciences & Services; Health Policy & Services; Public,
Environmental & Occupational Health
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health
GA BA3QN
UT WOS:000334643900004
ER
PT S
AU Borodin, O
Jow, TR
AF Borodin, Oleg
Jow, T. Richard
BE Smart, MC
Inaba, M
Fenton, J
Henderson, W
Ue, M
Doughty, DH
Jow, TR
Ishikawa, M
Bugga, RV
Tatsumi, K
Lucht, B
Trulove, PC
TI Quantum Chemistry Study of the Oxidation-Induced Decomposition of
Tetramethylene Sulfone (TMS) Dimer and TMS/BF4-
SO LITHIUM-ION BATTERIES -AND- NON-AQUEOUS ELECTROLYTES FOR LITHIUM
BATTERIES - PRIME 2012
SE ECS Transactions
LA English
DT Proceedings Paper
CT Symposia on Lithium-Ion Batteries and Non-Aqueous Electrolytes for
Lithium Batteries
CY OCT 07-12, 2012
CL Honolulu, HI
SP Electrochem Soc, Electrochem Soc Japan, Japan Soc Appl Phys, Korean Electrochem Soc, Royal Australian Chem Inst, Electrochemistry Div, Chinese Soc Electrochemistry, Battery Div, Energy Technol Div, Phys & Analyt Electrochemistry Div
ID LI-ION BATTERIES; DENSITY-FUNCTIONAL THEORY; NONCOVALENT INTERACTIONS;
ELECTROCHEMICAL WINDOWS; PROPYLENE CARBONATE; LITHIUM BATTERIES;
ELECTROLYTES; POTENTIALS; ANIONS; STABILITY
AB The oxidation-induced decomposition reactions of tetramethylene sulfone (TMS), its dimer and a TMS/BF4- complex were studied using M05-2X and LC-omega PBE density functionals in conjunction with a polarized continuum model (PCM). The presence of an anion or another TMS molecule near a TMS molecule was found to dramatically reduce the barriers for the initial step of the oxidation decomposition reactions of TMS and changed the order of the oxidation reactions and products. Specifically, the barrier for the H-abstraction reaction of TMS was reduced from 0.9-1.0 eV for isolated TMS to 0.1-0.2 eV in the TMS dimer. The presence of BF4- near TMS also reduced the barriers for both the TMS ring opening and the H-abstraction reactions. The most kinetically active reactions were (a) the TMS ring opening with a fluorine transfer from BF4- to the open TMS ring in the TMS/BF4- complex and (b) the intramolecular H-transfer from a methylene group to the sulfone oxygen in a TMS dimer. In the oxidized TMS2, the H-transfer reaction was assisted by the SO2-group from the neighboring TMS molecule. The ability of the M05-2X and LC-omega PBE density functionals to accurately describe TMS oxidation reactions was benchmarked through a comparison with the composite G4MP2 theory.
C1 [Borodin, Oleg; Jow, T. Richard] US Army Res Lab, Electrochem Branch, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Borodin, O (reprint author), US Army Res Lab, Electrochem Branch, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RI Borodin, Oleg/B-6855-2012
OI Borodin, Oleg/0000-0002-9428-5291
NR 37
TC 4
Z9 4
U1 0
U2 10
PU ELECTROCHEMICAL SOC INC
PI PENNINGTON
PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA
SN 1938-5862
BN 978-1-60768-414-5
J9 ECS TRANSACTIONS
PY 2013
VL 50
IS 26
BP 391
EP 398
DI 10.1149/05026.0391ecst
PG 8
WC Electrochemistry; Energy & Fuels
SC Electrochemistry; Energy & Fuels
GA BA8VT
UT WOS:000338893200035
ER
PT S
AU Ho, J
Jow, TR
AF Ho, Janet
Jow, T. Richard
GP IEEE
TI Effect of Crystallinity and Morphology on Dielectric Properties of PEEK
at Elevated Temperature
SO PROCEEDINGS OF THE 2013 IEEE INTERNATIONAL CONFERENCE ON SOLID
DIELECTRICS (ICSD 2013), VOLS 1 AND 2
SE IEEE International Conference on Solid Dielectrics-ICSD
LA English
DT Proceedings Paper
CT 11th IEEE International Conference on Solid Dielectrics (ICSD)
CY JUN 30-JUL 04, 2013
CL Bologna, ITALY
SP IEEE, IEEE Dielectr & Elect Insulat Soc, Univ Bologna, Dept Elect, Elect & Informat Engn, Lab Innovat Technol, Dow Inside, TECHMP
DE Poly(aryl ether ether ketone) (PEEK); high temperature polymer;
electrical conductivity; breakdown strength; crystallinity
ID POLY(ETHER ETHER KETONE); ELECTRICAL-CONDUCTION; POLYPROPYLENE;
POLYETHYLENE; BREAKDOWN; STRENGTH; BEHAVIOR; FILMS
AB Poly(aryl ether ether ketone) (PEEK) is one of the primary candidates for a high temperature capacitor dielectric as a result of its outstanding mechanical strength and thermal stability. However, its breakdown strength is unsatisfactory (similar to 400 MV/m) and high field (>100 MV/m) volumetric resistivity at elevated temperature is largely unknown. In this work, the inter-relationship among crystallinity, morphology, breakdown strength, and volumetric resistivity of PEEK at elevated temperature is studied in order to gain insight to factors which adversely affect breakdown. This paper presents preliminary results of the study.
C1 [Ho, Janet; Jow, T. Richard] US Army Res Lab, Adelphi, MD 20783 USA.
RP Ho, J (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
NR 17
TC 2
Z9 2
U1 2
U2 11
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1553-5282
BN 978-1-4673-4461-6
J9 IEEE INT C SOL DIEL
PY 2013
BP 385
EP 388
PG 4
WC Engineering, Electrical & Electronic; Materials Science,
Multidisciplinary
SC Engineering; Materials Science
GA BA9BL
UT WOS:000339117400088
ER
PT S
AU Grew, KN
Chu, D
AF Grew, Kyle. N.
Chu, Deryn
BE Wu, N
Dinh, H
Lee, JJ
Subramanian, R
Zou, Z
Chiu, W
Domen, K
Manivannan, A
Wang, H
Chu, D
Kulesza, PJ
Narayan, SR
Zhou, XD
TI Transport Phenomena in Bi-Cells for Portable Fuel Cell Power Sources
SO RENEWABLE FUELS FROM SUNLIGHT AND ELECTRICITY
SE ECS Transactions
LA English
DT Proceedings Paper
CT Symposium on Renewable Fuels from Sunlight and Elect held during the
PRiME Joint Int Meeting of the Electrochemical-Soc and the
Electrochemical-Soc-of-Japan
CY OCT 07-12, 2012
CL Honolulu, HI
SP Electrochem Soc, Electrochem Soc Japan, Japan Soc Appl Phys, Korean Electrochem Soc, Royal Australian Chem Inst, Electrochemistry Div, Chinese Soc Electrochemistry, Energy Technol Div, High Temp Mat Div, Phys & Analyt Electrochemistry Div, New Technol Subcommittee Div
ID WATER CROSSOVER; DMFC SYSTEM; PERFORMANCE; CHALLENGE; MEDIA
AB The specific energy of neat liquid methanol tends to provide direct methanol fuel cell (DMFC) systems with large energy densities, making them ideal for portable power applications. However, portable DMFC systems are larger than desired. The balance of plant (BOP) is the key contributor to the system volume, and specifically components used for water management. In this study, a theoretical approach is taken to better understand the water management requirements. A passive bi-cell, or pseudo bipolar, configuration is used as a baseline for this study.
C1 [Grew, Kyle. N.; Chu, Deryn] US Army Res Lab, Adelphi, MD 20910 USA.
RP Grew, KN (reprint author), US Army Res Lab, Adelphi, MD 20910 USA.
NR 8
TC 0
Z9 0
U1 0
U2 2
PU ELECTROCHEMICAL SOC INC
PI PENNINGTON
PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA
SN 1938-5862
BN 978-1-60768-437-4
J9 ECS TRANSACTIONS
PY 2013
VL 50
IS 49
BP 103
EP 112
DI 10.1149/05049.0103ecst
PG 10
WC Electrochemistry; Energy & Fuels; Physics, Applied
SC Electrochemistry; Energy & Fuels; Physics
GA BA8VU
UT WOS:000338897800012
ER
PT S
AU Mercado, RML
Fury, J
Kiely, MB
Buhrmaster, D
Miller, CE
Zarras, P
AF Mercado, R. M. L.
Fury, J.
Kiely, M. B.
Buhrmaster, D.
Miller, C. E.
Zarras, P.
BE UrquidiMacdonald, M
Taylor, CD
Haruna, T
TI Investigation of Zinc Dimercaptothiadiazole as a Corrosion Inhibitor for
Steel
SO CORROSION, PASSIVITY, AND ENERGY: A SYMPOSIUM IN HONOR OF DIGBY D.
MACDONALD
SE ECS Transactions
LA English
DT Proceedings Paper
CT ECS 3D Symposium on Corrosion, Passivity, and Energy - In Honor of Digby
D. Macdonald
CY OCT 07-12, 2012
CL Honolulu, HI
SP ECS, Corros Div
ID 2,5-DIMERCAPTO-1,3,4-THIADIAZOLE; ELECTRODEPOSITION; FILMS
AB The mechanism of corrosion inhibition of zinc dithiomercaptothiadiazole (Zn(DMcT)(2)) has been known and elucidated. The efficacy of (Zn(DMcT)(2)) as used in primer coatings for corrosion inhibition on steel alloys such as 1010 steel and 4130 high strength steel under neutral pH conditions was investigated by accelerated corrosion testing methodologies. Solution-state studies and surface elemental analyses were conducted to determine the possible mechanism of corrosion inhibition. Solution state experiments showed a correlation between increasing Zn(DMcT)(2) amounts and increased polarization resistance, but DMcT on its own did not show this relationship. Under neutral pH conditions, it was determined that Zn(II) species such as Zn(OH)(2), Zn(DMcT)(2), and possibly ZnO were deposited on the steel surface, providing corrosion protection.
C1 [Mercado, R. M. L.; Fury, J.; Kiely, M. B.] Crosslink, 950 Bolger Ct, St Louis, MO 63026 USA.
[Buhrmaster, D.] Univ Dayton, Res Inst, Dayton, OH 45469 USA.
[Miller, C. E.] US Army, Res Lab, RDL WMM C, Aberdeen Proving Ground, MD 21005 USA.
[Zarras, P.] NAWCWD, China Lake, CA 93555 USA.
RP Mercado, RML (reprint author), Crosslink, 950 Bolger Ct, St Louis, MO 63026 USA.
NR 13
TC 0
Z9 0
U1 0
U2 1
PU ELECTROCHEMICAL SOC INC
PI PENNINGTON
PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA
SN 1938-5862
BN 978-1-60768-419-0
J9 ECS TRANSACTIONS
PY 2013
VL 50
IS 31
BP 345
EP 354
DI 10.1149/05031.0345ecst
PG 10
WC Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary
SC Electrochemistry; Energy & Fuels; Materials Science
GA BA8FF
UT WOS:000338035300028
ER
PT S
AU Chung, K
Rozumov, E
Kaminsky, D
Buescher, T
Manship, T
Valdivia, A
Cook, P
Anderson, P
AF Chung, K.
Rozumov, E.
Kaminsky, D.
Buescher, T.
Manship, T.
Valdivia, A.
Cook, P.
Anderson, P.
BE PodlahaMurphy, EJ
Kanamura, K
Munakata, H
Fenton, JM
TI Development of Electrically Controlled Energetic Materials
SO EMERGING MATERIALS AND PROCESSES FOR ENERGY CONVERSION AND STORAG E
SE ECS Transactions
LA English
DT Proceedings Paper
CT Symposium on Emerging Mat and Proc for Energy Convers and Storage held
during the PRiME Joint Int Meeting of the Electrochem-Soc and the
Electrochem-Soc-of-Japan
CY OCT 07-12, 2012
CL Honolulu, HI
SP Electrochem Soc, Electrochem Soc Japan, Japan Soc Appl Phys, Korean Electrochem Soc, Royal Australian Chem Inst, Electrochemistry Div, Chinese Soc Electrochemistry, Electrodeposit Div, Battery Div, Energy Technol Div
AB U.S. Army ARDEC has been examining a novel pyroelectric-type material developed by Digital Solid State Propulsion, LLC for its unique combustion properties and insensitivity. This unique ECEM is formed using an ionic liquid oxidizer and polymer fuel, via sol-gel processes and is quite dense, making it very suitable for energetic applications in both the civilian and military fields. This ECEM is completely insensitive to the application of impact, flame, friction, and shock threats. Once a power of the required voltage is applied, the baseline ECEM rapidly initiates combustion with H2O, CO2, and N-2 formed as the only major gas phase products produced. Initial testing of ECEM in perforated pipes appears promising as indicated by uniform ignition along the entire length of the test assembly.
C1 [Chung, K.; Rozumov, E.; Kaminsky, D.; Cook, P.; Anderson, P.] US Army ARDEC, Picatinny Arsenal, NJ 07806 USA.
[Buescher, T.; Manship, T.; Valdivia, A.] LLC Reno, Reno, NV 89511 USA.
RP Chung, K (reprint author), US Army ARDEC, Picatinny Arsenal, NJ 07806 USA.
FU U.S. Army ARDEC's Science
FX This work has been supported from funding under the U.S. Army ARDECs
Science and Technology program.
NR 3
TC 0
Z9 0
U1 0
U2 3
PU ELECTROCHEMICAL SOC INC
PI PENNINGTON
PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA
SN 1938-5862
BN 978-1-60768-428-2
J9 ECS TRANSACTIONS
PY 2013
VL 50
IS 40
BP 59
EP 66
DI 10.1149/05040.0059ecst
PG 8
WC Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary;
Physics, Applied
SC Electrochemistry; Energy & Fuels; Materials Science; Physics
GA BA8HV
UT WOS:000338124800007
ER
PT S
AU Carpin, S
Chung, TH
Sadler, BM
AF Carpin, Stefano
Chung, Timothy H.
Sadler, Brian M.
GP IEEE
TI Theoretical Foundations of High-Speed Robot Team Deployment
SO 2013 IEEE INTERNATIONAL CONFERENCE ON ROBOTICS AND AUTOMATION (ICRA)
SE IEEE International Conference on Robotics and Automation ICRA
LA English
DT Proceedings Paper
CT IEEE International Conference on Robotics and Automation (ICRA)
CY MAY 06-10, 2013
CL Karlsruhe, GERMANY
SP IEEE
AB In this paper we study the multi-robot deployment problem under hard temporal constraints. After proposing a model for this task, we consider the simplest deployment algorithm and we analyze the relationship between three fundamental parameters, the temporal deadline, the probability of success, and the number of robots. Because an exact analysis of even the simplest algorithm is computationally intractable, we derive an approximate bound leading to performance curves useful to answer design questions (how many robots are needed to get a certain performance guarantee?) or analysis questions (what is the probability of success given a certain deadline and number of robots?) Simulations show that the bounds are sharp and provide a useful tool to predict team deployment performance and tradeoffs.
C1 [Carpin, Stefano] Univ Calif, Sch Engn, Merced, CA 95343 USA.
[Chung, Timothy H.] Naval Postgrade Sch, Monterey, CA USA.
[Sadler, Brian M.] Army Res Lab, Adelphi, MD USA.
RP Carpin, S (reprint author), Univ Calif, Sch Engn, Merced, CA 95343 USA.
EM scarpin@ucmerced.edu; thchung@nps.edu; brian.m.sadler6.civ@mail.mil
NR 9
TC 2
Z9 2
U1 0
U2 1
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1050-4729
BN 978-1-4673-5641-1; 978-1-4673-5643-5
J9 IEEE INT CONF ROBOT
PY 2013
BP 2033
EP 2040
PG 8
WC Automation & Control Systems; Engineering, Electrical & Electronic;
Robotics
SC Automation & Control Systems; Engineering; Robotics
GA BA7KQ
UT WOS:000337617302007
ER
PT S
AU Rogers, JG
Christensen, HI
AF Rogers, John G., III
Christensen, Henrik I.
GP IEEE
TI Robot Planning with a Semantic Map
SO 2013 IEEE INTERNATIONAL CONFERENCE ON ROBOTICS AND AUTOMATION (ICRA)
SE IEEE International Conference on Robotics and Automation ICRA
LA English
DT Proceedings Paper
CT IEEE International Conference on Robotics and Automation (ICRA)
CY MAY 06-10, 2013
CL Karlsruhe, GERMANY
SP IEEE
AB Context is an important factor for domestic service robots to consider when interpreting their environments to perform tasks. In people's homes, rooms are laid out in a specific arrangement to enable comfortable and efficient living; for example, the living room is central to the house, and the dining room is adjacent to the kitchen. The identity of the objects in a room are a strong cue for determining that room's purpose. This paper will present a planner for an autonomous mobile robot system which uses room connectivity topology and object understanding as context for an object search task in a domestic environment.
C1 [Rogers, John G., III] Army Res Lab, Adelphi, MD 20783 USA.
[Rogers, John G., III; Christensen, Henrik I.] Georgia Inst Technol, Coll Comp, Atlanta, GA 30332 USA.
RP Rogers, JG (reprint author), Army Res Lab, Adelphi, MD 20783 USA.
EM jgrogers@gmail.com; hic@cc.gatech.edu
FU ARL MAST CTA
FX This work was made possible through the ARL MAST CTA project. The
authors would also like to thank Carlos Nieto for his assistance in
performing the experiments
NR 18
TC 2
Z9 3
U1 0
U2 1
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1050-4729
BN 978-1-4673-5641-1; 978-1-4673-5643-5
J9 IEEE INT CONF ROBOT
PY 2013
BP 2239
EP 2244
PG 6
WC Automation & Control Systems; Engineering, Electrical & Electronic;
Robotics
SC Automation & Control Systems; Engineering; Robotics
GA BA7KQ
UT WOS:000337617302037
ER
PT S
AU Delmerico, JA
Baran, D
David, P
Ryde, J
Corso, JJ
AF Delmerico, Jeffrey A.
Baran, David
David, Philip
Ryde, Julian
Corso, Jason J.
GP IEEE
TI Ascending Stairway Modeling from Dense Depth Imagery for Traversability
Analysis
SO 2013 IEEE INTERNATIONAL CONFERENCE ON ROBOTICS AND AUTOMATION (ICRA)
SE IEEE International Conference on Robotics and Automation ICRA
LA English
DT Proceedings Paper
CT IEEE International Conference on Robotics and Automation (ICRA)
CY MAY 06-10, 2013
CL Karlsruhe, GERMANY
SP IEEE
ID VISION
AB Localization and modeling of stairways by mobile robots can enable multi-floor exploration for those platforms capable of stair traversal. Existing approaches focus on either stairway detection or traversal, but do not address these problems in the context of path planning for the autonomous exploration of multi-floor buildings. We propose a system for detecting and modeling ascending stairways while performing simultaneous localization and mapping, such that the traversability of each stairway can be assessed by estimating its physical properties. The long-term objective of our approach is to enable exploration of multiple floors of a building by allowing stairways to be considered during path planning as traversable portals to new frontiers. We design a generative model of a stairway as a single object. We localize these models with respect to the map, and estimate the dimensions of the stairway as a whole, as well as its steps. With these estimates, a robot can determine if the stairway is traversable based on its climbing capabilities. Our system consists of two parts: a computationally efficient detector that leverages geometric cues from dense depth imagery to detect sets of ascending stairs, and a stairway modeler that uses multiple detections to infer the location and parameters of a stairway that is discovered during exploration. We demonstrate the performance of this system when deployed on several mobile platforms using a Microsoft Kinect sensor.
C1 [Delmerico, Jeffrey A.; Ryde, Julian; Corso, Jason J.] SUNY Buffalo, Buffalo, NY 14260 USA.
[Baran, David; David, Philip] US Army Res Lab, Buffalo, NY 14260 USA.
RP Delmerico, JA (reprint author), SUNY Buffalo, Buffalo, NY 14260 USA.
EM jad12@buffalo.edu; david.g.baran.civ@mail.mil;
philip.j.david4.civ@mail.mil; jryde@buffalo.edu; jcorso@buffalo.edu
FU Federal Highway Administration [DTFH61-07-H-00023]; Army Research Office
[W911NF-ll-I-0090]; National Science Foundation CAREER [IIS-0845282]
FX This material is based upon work partially supported by the Federal
Highway Administration under Cooperative Agreement No.
DTFH61-07-H-00023, the Army Research Office (W911NF- ll-I-0090) and the
National Science Foundation CAREER grant (IIS-0845282). Any opinions,
findings, conclusions or recommendations are those of the authors and do
not necessarily reflect the views of the FHWA, ARO, or NSF
NR 21
TC 10
Z9 10
U1 0
U2 1
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1050-4729
BN 978-1-4673-5641-1; 978-1-4673-5643-5
J9 IEEE INT CONF ROBOT
PY 2013
BP 2283
EP 2290
PG 8
WC Automation & Control Systems; Engineering, Electrical & Electronic;
Robotics
SC Automation & Control Systems; Engineering; Robotics
GA BA7KQ
UT WOS:000337617302044
ER
PT J
AU Bakhtyar, R
Razmi, AM
Barry, DA
Kees, CE
Yeganeh-Bakhtiary, A
Miller, CT
AF Bakhtyar, R.
Razmi, A. M.
Barry, D. A.
Kees, C. E.
Yeganeh-Bakhtiary, A.
Miller, C. T.
TI Two-phase flow modeling of the influence of wave shapes and bed slope on
nearshore hydrodynamics
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article; Proceedings Paper
CT 12th International Coastal Symposium (ICS)
CY APR 09-12, 2013
CL Plymouth Univ, Sch Marine Sci & Engn, Coastal Proc Res Grp, Plymouth,
ENGLAND
HO Plymouth Univ, Sch Marine Sci & Engn, Coastal Proc Res Grp
DE Multi-phase flow; hydrodynamics; plunging breakers; spilling breakers;
TKE; wave types
ID SWASH-ZONE; BREAKING WAVES; NUMERICAL-SIMULATION; SURF ZONE; SEDIMENT
TRANSPORT; SHEET FLOW; BEACH; TURBULENCE; DYNAMICS
AB An Eulerian two-phase flow model (air-water) was used to simulate nearshore hydrodynamic processes driven by wave motion. The flow field was computed with the Reynolds-Averaged Navier-Stokes equations in conjunction with the Volume-Of-Fluid method and the RNG turbulence-closure scheme. To study the effects of different wave shapes on surf-swash zone hydrodynamics, a set of numerical experiments was carried out. Predictions of three wave theories (Airy, 2nd-order Stokes and 5th-order Stokes) were compared, with a focus on the turbulence and flow fields. Model performance was assessed by comparing numerical results with laboratory experimental observations. Relationships between the water depth, undertow, TKE and wave characteristics are presented. The results indicate that the characteristics of turbulence and flow, for example the position of wave breaking and magnitude of TKE, are affected by different wave types. Numerical simulations showed that only high-order Stokes wave theory predicts the nonlinearity required for predicting hydrodynamic characteristics in agreement with existing understanding of nearshore processes. Numerical simulations were run for different hydrodynamic conditions, but with a focus on different bed slopes. The transformation of incoming waves as they reach shallow water occurs closer to the shoreline for steeper profiles. Consistently, the peaks in TKE and wave set-up are shifted onshore for steeper slopes. The numerical results showed that TKE and undertow velocity are smaller on dissipative beaches than on intermediate beaches.
C1 [Bakhtyar, R.; Miller, C. T.] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27514 USA.
[Bakhtyar, R.; Kees, C. E.] US Army, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA.
[Bakhtyar, R.; Razmi, A. M.; Barry, D. A.] Ecole Polytech Fed Lausanne, Fac Environm Nat Architectural & Construit ENAC, CH-1015 Lausanne, Switzerland.
[Yeganeh-Bakhtiary, A.] Cardiff Univ, Sch Engn, Hydroenvironm Res Ctr, Cardiff CF10 3AX, S Glam, Wales.
RP Bakhtyar, R (reprint author), Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27514 USA.
EM roham.bakhtyar@unc.edu; amir.razmi@epfl.ch; andrew.barry@epfl.ch;
chris.kees@us.army.mil; yeganeh@cardiff.ac.uk; casey_miller@unc.edu
RI Barry, David/C-6077-2008; Miller, Cass T./I-6613-2012
OI Barry, David/0000-0002-8621-0425; Miller, Cass T./0000-0001-6082-9273
NR 31
TC 5
Z9 5
U1 2
U2 11
PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
EI 1551-5036
J9 J COASTAL RES
JI J. Coast. Res.
PY 2013
SI 65
BP 159
EP 164
DI 10.2112/SI65-028.1
PN 1
PG 6
WC Environmental Sciences; Geography, Physical; Geosciences,
Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA AJ8ZB
UT WOS:000337995500029
ER
PT S
AU Doyle, JD
Howard, IL
AF Doyle, Jesse D.
Howard, Isaac L.
GP DEStech Publicat, Inc
TI Rutting and Moisture Damage Resistance of High RAP Warm Mixed Asphalt:
Loaded Wheel Tracking vs. Conventional Methods
SO ASPHALT PAVING TECHNOLOGY 2013, VOL 82
SE Journal of the Association of Asphalt Paving Technologists
LA English
DT Proceedings Paper
CT Conference of the Association-of-Asphalt-Paving-Technologists (AAPT)
CY APR 07-10, 2013
CL Denver, CO
SP Assoc Asphalt Paving Technologists
DE loaded wheel tracking; WMA; RAP; rutting; moisture damage; PURWheel
ID MIXTURES; PERFORMANCE; TECHNOLOGY; PAVEMENT
AB An increased potential for moisture damage and rutting have been the two main problems with warm mix asphalt (WMA) implementation. The use of high reclaimed asphalt pavement (RAP) contents (25% or more) in WMA may alleviate these problems. At present, susceptibility to moisture damage and rutting are usually tested for independently; however, these distress mechanisms can be linked for in-service pavements. An enhanced loaded wheel tracking test performed on dry and wet specimens, the PURWheel, is investigated in this paper to evaluate the interaction of traffic and moisture. The PURWheel is also compared to conventional rutting and moisture damage tests. PURWheel results are used to evaluate performance of 25 and 50% RAP-WMA. Rutting and moisture susceptibility of the high RAP-WMA was comparable to current practice low RAP content hot mix asphalt (HMA).
C1 [Doyle, Jesse D.] US Army Engineer Res & Dev Ctr, Airfields & Pavements Branch, Geotech & Struct Lab, Vicksburg, MS 39180 USA.
[Howard, Isaac L.] Mississippi State Univ, Dept Civil & Environm Engn, Mississippi State, MS 39762 USA.
RP Doyle, JD (reprint author), US Army Engineer Res & Dev Ctr, Airfields & Pavements Branch, Geotech & Struct Lab, Vicksburg, MS 39180 USA.
NR 47
TC 3
Z9 3
U1 1
U2 2
PU DESTECH PUBLICATIONS, INC
PI LANCASTER
PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA
SN 0270-2932
J9 J ASSOC ASPHALT PAV
PY 2013
VL 82
BP 289
EP 325
DI 10.1080/14680629.2013.812841
PG 37
WC Construction & Building Technology; Engineering, Civil; Materials
Science, Multidisciplinary
SC Construction & Building Technology; Engineering; Materials Science
GA BA7HR
UT WOS:000337539100010
ER
PT J
AU Tandon, A
Brudnak, MJ
Stein, JL
Ersal, T
AF Tandon, Akshar
Brudnak, Mark J.
Stein, Jeffrey L.
Ersal, Tulga
GP ASME
TI AN OBSERVER BASED FRAMEWORK TO IMPROVE FIDELITY IN INTERNET-DISTRIBUTED
HARDWARE-IN-THE-LOOP SIMULATIONS
SO ASME 2013 DYNAMIC SYSTEMS AND CONTROL CONFERENCE, VOL 2
LA English
DT Proceedings Paper
CT ASME Dynamic Systems and Control Conference (DSCC)
CY OCT 21-23, 2013
CL Palo Alto, CA
SP ASME, Dynam Syst & Control Div
ID BILATERAL TELEOPERATION; TELEMANIPULATION; TRANSPARENCY; DESIGN
AB Co-simulating distributed hardware-in-the-loop systems in real time over the Internet entails communication delays that can lead to significant loss of fidelity and even instability in the system. To address this challenge, this paper proposes an observer based framework that, unlike previously reported efforts, does not require the observer to know and model the observed system dynamics. This is achieved by deriving the closed-loop dynamics of the observer based on a sliding surface. Even though the resulting error system does not necessarily stay on a sliding surface, its asymptotic convergence to zero is still guaranteed. First, this idea is developed for a generic networked system simulation framework and its stability is established. Then, it is applied to a mass-spring-damper system to illustrate the mechanics of the approach on a simple, linear example and demonstrate that the approach can stabilize the system that is otherwise unstable due to delay. Finally, a vehicle-engine-driver system simulation is considered to evaluate the performance of the approach on a more realistic, nonlinear example. An improvement of up to 33% is observed in the fidelity of the simulation. The conclusion is that the approach holds a significant potential to alleviate the negative impact of delay and improve the stability and fidelity of networked system simulations. Its benefits become more pronounced as the delay increases.
C1 [Tandon, Akshar; Stein, Jeffrey L.; Ersal, Tulga] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA.
[Brudnak, Mark J.] US Army RDECOM TARDEC, Hardware & Man Loop Simulat, Warren, MI 48397 USA.
RP Ersal, T (reprint author), Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA.
EM akshart@umich.edu; mark.j.brudnak.civ@mail.mil; stein@umich.edu;
tersal@umich.edu
FU Automotive Research Center (ARC); U.S. Army center of excellence
FX This work was supported by the Automotive Research Center (ARC), a U.S.
Army center of excellence in modeling and simulation of ground vehicles.
NR 21
TC 0
Z9 0
U1 0
U2 1
PU AMER SOC MECHANICAL ENGINEERS
PI NEW YORK
PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA
BN 978-0-7918-5613-0
PY 2013
AR UNSP V002T21A004
DI 10.1115/DSCC2013-3878
PG 9
WC Automation & Control Systems; Engineering, Mechanical
SC Automation & Control Systems; Engineering
GA BA5WL
UT WOS:000337043200022
ER
PT J
AU Yheulon, CG
Gagliano, RA
AF Yheulon, Christopher G.
Gagliano, Ronald A.
TI Multiple Successful Emergent Peristomal Bowel Resections under Regional
Anesthesia in a Patient with Colonic Pseudo-obstruction and Severe
Chronic Obstructive Pulmonary Disease
SO AMERICAN SURGEON
LA English
DT Article
C1 [Yheulon, Christopher G.; Gagliano, Ronald A.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA.
RP Yheulon, CG (reprint author), Tripler Army Med Ctr, Dept Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM Christopher.yheulon@us.army.mil
NR 4
TC 1
Z9 1
U1 0
U2 0
PU SOUTHEASTERN SURGICAL CONGRESS
PI CUMMING
PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD JAN
PY 2013
VL 79
IS 1
BP E47
EP E48
PG 2
WC Surgery
SC Surgery
GA AI6DT
UT WOS:000336961200019
PM 23317608
ER
PT J
AU Weiss, CA
Moser, RD
Torres-Cancel, K
Negron, OR
Hidalgo-Hernandez, RG
Allison, PG
Chandler, MQ
Morefield, SW
Malone, PG
AF Weiss, Charles A.
Moser, Robert D.
Torres-Cancel, Kevin
Negron, Omar R.
Hidalgo-Hernandez, Ruth G.
Allison, P. G.
Chandler, Mei Q.
Morefield, Sean W.
Malone, Philip G.
TI Production of mixed carbonate phases using ammonium carbonate-metal
acetate reactions
SO BIOINSPIRED BIOMIMETIC AND NANOBIOMATERIALS
LA English
DT Article
DE biomimetic materials; bioinspired; calcium carbonate; composites;
electron microscopy; mineralisation; phase change materials; X-ray
diffraction
ID PRECIPITATION
AB Materials such as bone, nacre, and fish scales have unique structures that give the material strength as well as ductility. The ultimate goal of our research is to develop new composite materials that have improved strength and ductility compared to conventional materials. The US Army Engineer Research and Development Center is incorporating these design principles to develop hierarchical materials for structural applications. In the present study, the mineralogy and morphology of calcium-containing carbonates precipitated by reacting (NH4)(2)CO3 with mixed Ca, Sr, Mg, and Mn-acetates was investigated. As the proportion of the non-Ca component increased, the products shifted toward double carbonates and mixtures of double carbonates with single carbonates. Characterization by scanning electron microscopy and X-ray diffraction to determine crystal sizes, morphology, and structure of precipitated phases indicated a potential for re-crystallizing the products to form new composite materials. Ongoing research efforts are focused on using information obtained in the present study to develop composites by hydrothermal recrystallization of metastable phases.
C1 [Weiss, Charles A.; Moser, Robert D.; Torres-Cancel, Kevin; Hidalgo-Hernandez, Ruth G.; Allison, P. G.; Chandler, Mei Q.; Morefield, Sean W.; Malone, Philip G.] US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA.
[Negron, Omar R.] Univ Puerto Rico, Dept Mech Engn, Mayaguez, PR USA.
RP Weiss, CA (reprint author), US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA.
EM charles.a.weiss@usace.army.mil
FU Center-Directed Research Program of the US Army Engineer Research and
Development Center
FX The authors would like to acknowledge financial support for this work
provided by the Center-Directed Research Program of the US Army Engineer
Research and Development Center. Permission to publish was granted by
Director, Geotechnical and Structures Laboratory.
NR 13
TC 0
Z9 0
U1 0
U2 2
PU ICE PUBLISHING
PI WESTMINISTER
PA INST CIVIL ENGINEERS, 1 GREAT GEORGE ST, WESTMINISTER SW 1P 3AA, ENGLAND
SN 2045-9858
EI 2045-9866
J9 BIOINSPIR BIOMIM NAN
JI Bioinspired Biomim. Nanobiomat.
PY 2013
VL 2
IS 2
BP 59
EP 64
DI 10.1680/bbn.12.00017
PG 6
WC Engineering, Biomedical; Materials Science, Biomaterials
SC Engineering; Materials Science
GA AH8ZM
UT WOS:000336427600002
ER
PT S
AU Zainuddin, S
Hosur, MV
Jeelani, S
Kumar, A
Trovillion, J
AF Zainuddin, S.
Hosur, M. V.
Jeelani, S.
Kumar, A.
Trovillion, J.
BE Bai, J
TI Improving the durability of advanced fiber-reinforced polymer (FRP)
composites using nanoclay
SO ADVANCED FIBRE-REINFORCED POLYMER (FRP) COMPOSITES FOR STRUCTURAL
APPLICATIONS
SE Woodhead Publishing Series in Civil and Structural Engineering
LA English
DT Article; Book Chapter
DE nanocomposites; environmental degradation; moisture absorption; flexure
test
ID LAYERED SILICATE NANOCOMPOSITES; EPOXY COMPOSITES; BARRIER PROPERTIES;
MECHANICAL-PROPERTIES; CLAY NANOCOMPOSITES; WATER-ABSORPTION; GAS
PERMEATION; MOISTURE; DAMAGE; GLASS
AB In this chapter, we report the findings of experimental investigations conducted on durability of glass fiber-reinforced polymer (GFRP) composites with and without the addition of montmorillonite nanoclay. First, neat and nanoclay-added epoxy systems were characterized to evaluate the extent of clay platelet exfoliation and dispersion of nanoclay. GFRP composite panels were then fabricated with neat/modified epoxy resin and exposed to six different conditions, i.e. hot-dry/wet, cold-dry/wet, ultraviolet radiation and alternate ultraviolet radiation-condensation. Room temperature condition samples were also used for baseline consideration. An improved dispersion of nanoclay and exfoliation of clay platelets were observed in 2 wt% of epoxy samples. Weight change, discoloration and significant reduction in properties were observed in all conditioned GFRP samples. However, addition of nanoclay considerably improved the durability of GFRP samples as evident from the mechanical and micrographical results in comparison to neat samples subjected to similar conditions.
C1 [Zainuddin, S.; Hosur, M. V.; Jeelani, S.] Tuskegee Univ, Dept Mat Sci & Engn, Tuskegee, AL 36088 USA.
[Kumar, A.; Trovillion, J.] US Army Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61821 USA.
RP Zainuddin, S (reprint author), Tuskegee Univ, Dept Mat Sci & Engn, Tuskegee, AL 36088 USA.
EM szainuddin@mytu.tuskegee.edu; ashok.kumar@usace.army.mil
NR 62
TC 0
Z9 0
U1 0
U2 3
PU WOODHEAD PUBL LTD
PI CAMBRIDGE
PA ABINGTON HALL ABINGTON, CAMBRIDGE CB1 6AH, CAMBS, ENGLAND
SN 2052-4714
BN 978-0-85709-864-1; 978-0-85709-418-6
J9 WOOD PUBL SER CIVIL
PY 2013
VL 46
BP 780
EP 813
DI 10.1533/9780857098641.4.780
D2 10.1533/9780857098641
PG 34
WC Engineering, Civil; Polymer Science
SC Engineering; Polymer Science
GA BA2CZ
UT WOS:000333303300021
ER
PT J
AU Fletes, FJ
Kwak, E
Vanet, J
AF Fletes, F. J.
Kwak, E.
Vanet, J.
TI A COMPARISON OF THE UNITED STATES' FDA APPROVAL PROCESS AND EUROPEAN EMA
APPROVAL PROCESS
SO EUROPEAN PSYCHIATRY
LA English
DT Meeting Abstract
C1 [Fletes, F. J.; Kwak, E.; Vanet, J.] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0924-9338
EI 1778-3585
J9 EUR PSYCHIAT
JI Eur. Psychiat.
PY 2013
VL 28
SU 1
MA 2231
PG 1
WC Psychiatry
SC Psychiatry
GA AG5LN
UT WOS:000335460601803
ER
PT J
AU Nelson, AJ
Page, MA
Ginsberg, MD
Rood, MJ
AF Nelson, Andrew J.
Page, Martin A.
Ginsberg, Mark D.
Rood, Mark J.
TI Bench-Scale Aerosol Filtration Test System and Evaluation of an Acoustic
Bioaerosol Removal Device for Indoor Air Streams
SO AEROSOL SCIENCE AND TECHNOLOGY
LA English
DT Article
ID SUBMICROMETER PARTICLES; MICROORGANISMS; AGGLOMERATION; PERFORMANCE;
FILTERS; WAVES; DESIGN
AB It is important to have well-defined, reproducible methods to evaluate and compare newly developed air filtration equipment. To facilitate accurate assessment of air purification devices at the bench scale, an experimental system was designed, built, and documented to evaluate particulate removal efficiency (PRE) of air filtration devices based on principles used in ASHRAE standards. The system was then carefully characterized and used to evaluate PRE and total energy consumption of a novel acoustically enhanced impaction (AEI) air purification device. The AEI device demonstrated 99.998% PRE of 0.5-1.5m diameter KCl particles while causing a 120 Pa pressure drop and requiring a total of 3.0W/l of air treated at indoor ambient conditions. A single element of the AEI device operated in a biological safety level 2 facility was then used to evaluate PRE of bioaerosol consisting of Bacillus cereus (BC) spores. PRE of BC was 99.86 0.05% at indoor ambient temperature and pressure. This research describes the use of the Bench-scale Air Purification Testing and Evaluation Chamber (BAP-TEC) to experimentally evaluate and compare PRE and total energy requirements of novel air purification devices at the bench scale (280-1400 alpm). Further, an AEI device containing a fibrous filter media and high intensity sound field in the same control volume is evaluated using the BAP-TEC. Temporally resolved PRE of a bioaerosol by the AEI is also presented.Copyright 2013 American Association for Aerosol Research
C1 [Nelson, Andrew J.; Page, Martin A.; Ginsberg, Mark D.] US Army Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA.
[Nelson, Andrew J.; Rood, Mark J.] Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61801 USA.
RP Nelson, AJ (reprint author), US Army Engineer Res & Dev Ctr, Construct Engn Res Lab, POB 9005, Champaign, IL 61826 USA.
EM Andrew.J.Nelson@usace.army.mil
FU Defense Threat Reduction Agency; Department of Defense Science,
Mathematics, and Research for Transformation (SMART) Scholarship
FX Financial support is acknowledged from the Defense Threat Reduction
Agency and the Department of Defense Science, Mathematics, and Research
for Transformation (SMART) Scholarship administered by the American
Society for Engineering Education. The authors would also like to thank
Professor Tami Bond and Dr. Benjamin Brem for generously allowing access
to equipment necessary for aerosol generation and analysis.
NR 36
TC 0
Z9 0
U1 2
U2 12
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 520 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0278-6826
EI 1521-7388
J9 AEROSOL SCI TECH
JI Aerosol Sci. Technol.
PY 2013
VL 47
IS 12
BP 1285
EP 1292
DI 10.1080/02786826.2013.835026
PG 8
WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences;
Meteorology & Atmospheric Sciences
SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric
Sciences
GA AF8VM
UT WOS:000334993700001
ER
PT B
AU Vorontsov, M
Weyrauch, T
Lachinova, S
Ryan, T
Deck, A
Gatz, M
Paramonov, V
Carhart, G
AF Vorontsov, Mikhail
Weyrauch, Thomas
Lachinova, Svetlana
Ryan, Thomas
Deck, Andrew
Gatz, Micah
Paramonov, Vladimir
Carhart, Gary
BE Brignon, A
TI Coherent Beam Combining and Atmospheric Compensation with Adaptive Fiber
Array Systems
SO COHERENT LASER BEAM COMBINING
LA English
DT Article; Book Chapter
ID PHASE-DISTORTION CORRECTION; KM PROPAGATION PATH; BASIC CONSIDERATIONS;
DIRECTED-ENERGY; OPTICAL-SYSTEMS; SPECKLE-FIELD; HIGH-POWER; PROJECTION;
OPTIMIZATION; COLLIMATORS
C1 [Vorontsov, Mikhail; Weyrauch, Thomas; Gatz, Micah] Univ Dayton, Sch Engn, Intelligent Opt Lab, Dayton, OH 45469 USA.
[Vorontsov, Mikhail; Lachinova, Svetlana; Ryan, Thomas; Deck, Andrew; Paramonov, Vladimir] Optonicus, Dayton, OH 45402 USA.
[Carhart, Gary] US Army Res Lab, Computat & Informat Sci Directorate, Intelligent Opt Lab, Adelphi, MD 20783 USA.
RP Vorontsov, M (reprint author), Univ Dayton, Sch Engn, Intelligent Opt Lab, 300 Coll Pk, Dayton, OH 45469 USA.
NR 43
TC 5
Z9 5
U1 0
U2 1
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
BN 978-3-527-65280-8; 978-3-527-41150-4
PY 2013
BP 167
EP 191
D2 10.1002/9783527652778
PG 25
WC Physics, Applied
SC Physics
GA BA1JQ
UT WOS:000332649500007
ER
PT J
AU Verba, R
Tiberkevich, V
Bankowski, E
Meitzler, T
Melkov, G
Slavin, A
AF Verba, Roman
Tiberkevich, Vasil
Bankowski, Elena
Meitzler, Thomas
Melkov, Gennadiy
Slavin, Andrei
TI Localized Defect Modes in a Two-Dimensional Array of Magnetic Nanodots
SO IEEE MAGNETICS LETTERS
LA English
DT Article
DE Nanomagnetics; spin waves; magnonic crystal; magnetic dot; ferromagnetic
resonance
AB The microwave properties of an array of magnetic nanodots in a ferromagnetic state having a point defect-a dot with inverted magnetization or different material parameters-are considered. The existence of a single-point defect in a dot array may lead to the appearance of several localized modes: one "defect eigenmode" and several "well modes," the number and structure of which strongly depend on the magnetostatic interactions between the dots. By performing a ferromagnetic resonance experiment on an array of magnetic dots containing a small number of defects, it is possible to obtain information about the entire spin-wave spectrum of the array.
C1 [Verba, Roman; Melkov, Gennadiy] Taras Shevchenko Natl Univ Kyiv, Fac Radiophys, UA-01601 Kiev, Ukraine.
[Tiberkevich, Vasil; Slavin, Andrei] Oakland Univ, Dept Phys, Rochester, MI 48309 USA.
[Bankowski, Elena; Meitzler, Thomas] US Army TARDEC, Warren, MI 48397 USA.
RP Verba, R (reprint author), Taras Shevchenko Natl Univ Kyiv, Fac Radiophys, UA-01601 Kiev, Ukraine.
EM verrv@ukr.net
RI Tiberkevich, Vasil/A-8697-2008; Verba, Roman/J-4452-2014; Meitzler,
Thomas/D-1065-2017
OI Tiberkevich, Vasil/0000-0002-8374-2565; Verba,
Roman/0000-0001-8811-6232;
FU National Science Foundation, USA [DMR-1015175]; U.S. Army TARDEC,
RDECOM; DARPA MTO/MESO [N66001-11-1-4114]; SFFR (DFFD) of Ukraine
[UU34/008]
FX This work was supported by Grant DMR-1015175 from the the National
Science Foundation, USA; by a contract from the U.S. Army TARDEC,
RDECOM; by DARPA MTO/MESO under Grant N66001-11-1-4114; and by Grant
UU34/008 from the SFFR (DFFD) of Ukraine.
NR 13
TC 3
Z9 3
U1 1
U2 13
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1949-307X
J9 IEEE MAGN LETT
JI IEEE Magn. Lett.
PY 2013
VL 4
AR 4000404
DI 10.1109/LMAG.2013.2277995
PG 4
WC Engineering, Electrical & Electronic; Physics, Applied
SC Engineering; Physics
GA AF7VD
UT WOS:000334922100012
ER
PT B
AU Arney, C
Coronges, K
Fletcher, H
Hagen, J
Hutchinson, K
Moss, A
Thomas, C
AF Arney, Chris
Coronges, Kate
Fletcher, Hilary
Hagen, John
Hutchinson, Kira
Moss, Allen
Thomas, Charles
GP IEEE
TI Using Rare Event Modeling & Networking to Build Scenarios and Forecast
the Future
SO PROCEEDINGS OF THE 2013 IEEE 2ND INTERNATIONAL NETWORK SCIENCE WORKSHOP
(NSW)
LA English
DT Proceedings Paper
CT IEEE 2nd Network Science Workshop (NSW)
CY APR 29-MAY 01, 2013
CL West Point, NY
SP IEEE, IEEE Comp Soc, Network Sci Ctr, Army Res Off, IEEE Task Force Network Sci
DE black swan; tipping point; scenario; wargame; future planning
AB Recent history has reminded society that prediction in the forms of scenario generation, red-teaming, war-gaming, and future planning must incorporate innovative perspectives such as rare, but impactful, events and multiple phased events. Rare event modeling is based on the premise that important events can be dominated by outliers. Current forecasting focuses on probable events. Likewise, multiple-phased actions can create paradigm shifts that move events in a new direction or push them to higher levels of impact. Therefore, impact potential must be understood, calculated, and utilized. Our network-based scenario development system provides for state-change and high-impact scenario events that enable impact measures to be calculated and used by decision makers.
C1 [Arney, Chris; Coronges, Kate; Fletcher, Hilary; Hagen, John; Moss, Allen; Thomas, Charles] US Mil Acad, West Point, NY 10996 USA.
[Hutchinson, Kira] Univ Foreign Mil & Cultural Studies, US Army Training & Doctrine Command, Ft Monrce, VA 23651 USA.
RP Arney, C (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 17
TC 0
Z9 0
U1 0
U2 4
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4799-0436-5; 978-1-4799-0203-3
PY 2013
BP 31
EP 36
PG 6
WC Computer Science, Hardware & Architecture; Computer Science, Theory &
Methods; Engineering, Electrical & Electronic
SC Computer Science; Engineering
GA BA4BC
UT WOS:000335317000005
ER
PT B
AU Leung, A
Dron, W
Purnell, J
Srivastava, J
Mahapatra, A
Roy, A
Hancock, JP
Aguirre, M
Han, JW
Wang, C
Scott, L
AF Leung, Alice
Dron, William
Purnell, Jon
Srivastava, Jaideep
Mahapatra, Amogh
Roy, Atanu
Hancock, John P.
Aguirre, Matthew
Han, Jiawei
Wang, Chi
Scott, Lisa
GP IEEE
TI Social Patterns: Community Detection Using Behavior-Generated Network
Datasets
SO PROCEEDINGS OF THE 2013 IEEE 2ND INTERNATIONAL NETWORK SCIENCE WORKSHOP
(NSW)
LA English
DT Proceedings Paper
CT IEEE 2nd Network Science Workshop (NSW)
CY APR 29-MAY 01, 2013
CL West Point, NY
SP IEEE, IEEE Comp Soc, Network Sci Ctr, Army Res Off, IEEE Task Force Network Sci
DE community detection; group detection; clustering; rule-based behaviors;
generated datasets; communication models
AB A set of behavior rules, personal characteristics, group affiliations and roles was used to generate a dataset of mixed communication actions modeling those at a large organization. Several different approaches to community detection and modeling were applied to this generated dataset, in order to compare the strengths and range of applicability of different algorithms. Graph partitioning methods performed well at assigning membership to formal, exclusive groups such as organizational departments, if there is a priori knowledge of the target number of groups. SSDE-cluster, a fast and scalable algorithm, performed well in detecting normal departments and can be used when the number of groups is not known. It also was able to detect small overlapping groups, but with only moderate accuracy. Clique enumeration performed well in detecting small overlapping groups, when a priori knowledge of average group size was used. Different methods of constructing social network graphs from the mixed communication actions were investigated, as well as different link weighing methods. We conclude that behavior-generated datasets with complex and complete ground truths are useful for collaborative validation of different community and role detection and modeling methods.
C1 [Leung, Alice; Dron, William] BBN Technol, Cambridge, MA 02138 USA.
[Purnell, Jon] Microsoft, Mountain View, CA USA.
[Srivastava, Jaideep; Mahapatra, Amogh] Univ Minnesota, Minneapolis, MN 55455 USA.
[Hancock, John P.; Aguirre, Matthew] Artis Tech Inc, Fairfax, VA USA.
[Han, Jiawei; Wang, Chi] Univ Illinois, Chicago, IL 60680 USA.
[Scott, Lisa] Army Res Lab, Adelphi, MD USA.
RP Leung, A (reprint author), BBN Technol, Cambridge, MA 02138 USA.
EM aleung@bbn.com; wdron@bbn.com; jopurnel@microsoft.com;
srivastava@cs.umn.edu; atanu@cs.umn.edu; johnh@artistech.com;
matta@artistech.com; han@cs.uiuc.edu; chiwang1@illinois.edu
OI Srivastava, Jaideep/0000-0001-9385-7545
NR 9
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4799-0436-5; 978-1-4799-0203-3
PY 2013
BP 82
EP 89
PG 8
WC Computer Science, Hardware & Architecture; Computer Science, Theory &
Methods; Engineering, Electrical & Electronic
SC Computer Science; Engineering
GA BA4BC
UT WOS:000335317000012
ER
PT B
AU James, J
Mabry, F
St Leger, A
Cook, T
Huggins, K
AF James, John
Mabry, Frank
St Leger, Aaron
Cook, Tom
Huggins, Kevin
GP IEEE
TI Cyber-Physical Situation Awareness and Decision Support
SO PROCEEDINGS OF THE 2013 IEEE 2ND INTERNATIONAL NETWORK SCIENCE WORKSHOP
(NSW)
LA English
DT Proceedings Paper
CT IEEE 2nd Network Science Workshop (NSW)
CY APR 29-MAY 01, 2013
CL West Point, NY
SP IEEE, IEEE Comp Soc, Network Sci Ctr, Army Res Off, IEEE Task Force Network Sci
DE situation awareness; communication network; information network;
social/cognitive network; cyber-physical
AB Cyber-physical situation awareness is essential to management of government services and conduct of business processes. In particular, all of the nation's critical infrastructures depend upon proper operation of supervisory control and data acquisition (SCADA) devices and proper operation of these devices faces threats from possible occurrences of a variety of deliberate and inadvertent cyber events. This paper discusses an ongoing approach for incrementally improving cyber-physical situation awareness by (1) extending previous results for information architecture understanding, (2) sharing protected information among information owners whose knowledge (measurement) of their own state can be improved by choosing to share information with others, and (3) comparing measured cyber-physical system state to predicted cyber-physical system state.
C1 [James, John; Mabry, Frank; St Leger, Aaron; Cook, Tom; Huggins, Kevin] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA.
RP James, J (reprint author), US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA.
EM John.James@usma.edu; Frank.Mabry@usma.edu; Aaron.StLeger@usma.edu;
Tom.Cook@usma.edu; Kevin.Huggins@usma.edu
NR 5
TC 0
Z9 0
U1 1
U2 2
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4799-0436-5; 978-1-4799-0203-3
PY 2013
BP 114
EP 117
PG 4
WC Computer Science, Hardware & Architecture; Computer Science, Theory &
Methods; Engineering, Electrical & Electronic
SC Computer Science; Engineering
GA BA4BC
UT WOS:000335317000019
ER
PT B
AU Shakarian, P
Subrahmanian, VS
AF Shakarian, Paulo
Subrahmanian, V. S.
GP IEEE
TI Geospatial Optimization Problems
SO PROCEEDINGS OF THE 2013 IEEE 2ND INTERNATIONAL NETWORK SCIENCE WORKSHOP
(NSW)
LA English
DT Proceedings Paper
CT IEEE 2nd Network Science Workshop (NSW)
CY APR 29-MAY 01, 2013
CL West Point, NY
SP IEEE, IEEE Comp Soc, Network Sci Ctr, Army Res Off, IEEE Task Force Network Sci
AB There are numerous applications which require the ability to take certain actions (e. g. distribute money, medicines, people etc.) over a geographic region in order to optimize an objective (e. g. minimize expected number of people with a disease). We introduce "geospatial optimization problems" (GOPs) where an agent has limited resources and budget to take actions in a geographic area. The actions result in one or more properties changing for one or more locations. There are also certain constraints on the combinations of actions that can be taken. We study two types of GOPs - goal-based and benefit-maximizing (GBGOP and BMGOP respectively). A GBGOP ensures that certain properties must be true at specified locations after the actions are taken while a BMGOP optimizes a linear benefit function. We present several approaches to these problems using various integer programs as well as a multiplicative update based approximation.
C1 [Shakarian, Paulo] US Mil Acad, Network Sci Ctr, West Point, NY 10996 USA.
[Subrahmanian, V. S.] Univ Maryland, Dept Comp Sci, College Pk, MD USA.
RP Shakarian, P (reprint author), US Mil Acad, Network Sci Ctr, West Point, NY 10996 USA.
EM paulo@shakarian.net; vs@cs.umd.edu
FU Army Research Office [2GDATXR042]; U.S. Military Academy
FX Some of the authors are supported under by the Army Research Office
(project 2GDATXR042). The opinions in this paper are those of the
authors and do not necessarily reflect the opinions of the funders, the
U.S. Military Academy, or the U.S. Army.
NR 3
TC 0
Z9 0
U1 0
U2 1
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4799-0436-5; 978-1-4799-0203-3
PY 2013
BP 118
EP 121
PG 4
WC Computer Science, Hardware & Architecture; Computer Science, Theory &
Methods; Engineering, Electrical & Electronic
SC Computer Science; Engineering
GA BA4BC
UT WOS:000335317000020
ER
PT B
AU Cosenzo, KA
Szymanski, BK
AF Cosenzo, Keryl Ann
Szymanski, Boleslaw Karol
GP IEEE
TI Challenges of Social Cognitive Network Science: Network Science
Collaborative Technology Alliance Perspective
SO PROCEEDINGS OF THE 2013 IEEE 2ND INTERNATIONAL NETWORK SCIENCE WORKSHOP
(NSW)
LA English
DT Proceedings Paper
CT IEEE 2nd Network Science Workshop (NSW)
CY APR 29-MAY 01, 2013
CL West Point, NY
SP IEEE, IEEE Comp Soc, Network Sci Ctr, Army Res Off, IEEE Task Force Network Sci
DE social cognitive networks; communities; trust; team performance
AB This paper reviews challenges and summarize the progress accomplished by the Social Cognitive Networks Academic Research Center of the Network Science Collaborative Technology Alliance. The focus is on potential impact that this research may have on unique needs of military, foremost the US Army, to effectively and efficiently operate in the increasingly complex and interconnected networks of societies and their component communities. The review of the progress and current status of research of the center provide state-of-the-art view of the relevant areas of social cognitive network science.
C1 [Cosenzo, Keryl Ann] US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Szymanski, Boleslaw Karol] Rensselaer Polytech Inst, Social Cognit Networks Acad Res Ctr, Troy, NY USA.
RP Cosenzo, KA (reprint author), US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM Keryl.a.Cosenz.civ@mail.mil; szymab@rpi.edu
RI Szymanski, Boleslaw/A-9121-2009
OI Szymanski, Boleslaw/0000-0002-0307-6743
FU Army Research Laboratory [W911NF-09-2-0053]
FX Research was sponsored by the Army Research Laboratory and was
accomplished under Cooperative Agreement Number W911NF-09-2-0053. The
views and conclusions contained in this document are those of the
authors and should not be interpreted as representing the official
policies, either expressed or implied, of the Army Research Laboratory
or the U.S. Government. The U.S. Government is authorized to reproduce
and distribute reprints for Government purposes notwithstanding any
copyright notation here on.
NR 9
TC 0
Z9 0
U1 1
U2 5
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4799-0436-5; 978-1-4799-0203-3
PY 2013
BP 122
EP 125
PG 4
WC Computer Science, Hardware & Architecture; Computer Science, Theory &
Methods; Engineering, Electrical & Electronic
SC Computer Science; Engineering
GA BA4BC
UT WOS:000335317000021
ER
PT J
AU Hsu, KY
Yang, MH
Jheng, DY
Huang, SL
Mennemann, K
Dietrich, V
Dubinskii, M
AF Hsu, Kuang-Yu
Yang, Mu-Han
Jheng, Dong-Yo
Huang, Sheng-Lung
Mennemann, Karl
Dietrich, Volker
Dubinskii, Mark
GP IEEE
TI Single Crystalline YAG-core Fiber with a Lanthanum Dense Flint Glass
Cladding
SO 2013 CONFERENCE ON LASERS AND ELECTRO-OPTICS PACIFIC RIM (CLEO-PR)
LA English
DT Proceedings Paper
CT 10th Conference on Lasers and Electro-Optics Pacific Rim (CLEO-PR)
CY JUN 30-JUL 04, 2013
CL Kyoto, JAPAN
SP IEICE Commun Soc, IEICE Elect Soc, Japan Soc Appl Phys, IEEE Photon Soc, Opt Soc, Opt Soc Korea, Korean Phys Soc, Agilent Technologies Japan Ltd, Hamamatsu Photon K K, Tektronix Japan, Thorlabs Japan Inc
AB The crystalline YAG-core fiber cladded by high-index N-LaSF9 glass has been fabricated to significantly reduce the number of guided modes. The selective propagation of the LP01 and LP11 modes was successfully demonstrated at 633 nm.
C1 [Hsu, Kuang-Yu; Yang, Mu-Han; Jheng, Dong-Yo; Huang, Sheng-Lung] Natl Taiwan Univ, Gratuate Inst Photon & Optoelect, Taipei 106, Taiwan.
[Mennemann, Karl; Dietrich, Volker] Johannes Gutenberg Univ Mainz, Adv Opt, D-55122 Mainz, Germany.
[Dubinskii, Mark] US Army, Res Lab, Adelphi, MD 20783 USA.
RP Hsu, KY (reprint author), Natl Taiwan Univ, Gratuate Inst Photon & Optoelect, Taipei 106, Taiwan.
EM slhuang@cc.ee.ntu.edu.tw
NR 5
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4673-6476-8
PY 2013
PG 2
WC Engineering, Electrical & Electronic; Optics; Physics, Applied
SC Engineering; Optics; Physics
GA BA3FB
UT WOS:000334176100392
ER
PT S
AU Shay, LA
Conti, G
Hartzog, W
AF Shay, Lisa A.
Conti, Gregory
Hartzog, Woodrow
GP IEEE
TI Beyond Sunglasses and Spray Paint: A Taxonomy of Surveillance
Countermeasures
SO 2013 IEEE INTERNATIONAL SYMPOSIUM ON TECHNOLOGY AND SOCIETY (ISTAS)
SE IEEE International Symposium on Technology and Society
LA English
DT Proceedings Paper
CT IEEE International Symposium on Technology and Society (ISTAS)
CY JUN 27-29, 2013
CL Univ Toronto, Engn Bahen Ctr Informat Technol, Toronto, CANADA
SP IEEE, Univ Toronto, IEEE Soc Social Implicat Technol, Univ Wollongong, Int Federat Med & Biol Engn, Prod Safety Engn Soc, ACM Comp Soc, Epson, APX Labs, MetaView, Autographer, Streamfolio, buildAR, Uberveillance, Optinvent, Cisco, Singularity Weblog, Augmented Real Org, Augmate Corp, Infin AR, Inst Infocomm Res
HO Univ Toronto, Engn Bahen Ctr Informat Technol
DE panopticon; uberveillance; veillance; surveillance; privacy;
countermeasures
AB The rapid decline in size and cost of networked sensors combined with increased incentives for use including monitoring physical fitness, improving public safety, increasing security, and adding convenience is causing the physical and online worlds to become heavily instrumented. Some welcome such developments, but others seek to retain privacy, often by focusing on countering the sensors themselves. Scholars have begun to consider surveillance countermeasures as a stand-alone area of research. However, a scholarly taxonomy useful for critical analysis and systematic countermeasure development is lacking. In this paper we provide such a taxonomy illustrated with example countermeasures that have been successfully employed.
C1 [Shay, Lisa A.; Conti, Gregory] US Mil Acad, Cyber Res Ctr, West Point, NY 10996 USA.
[Hartzog, Woodrow] Samford Univ, Cumberland Sch Law, Homewood, AL 35229 USA.
RP Shay, LA (reprint author), US Mil Acad, Cyber Res Ctr, West Point, NY 10996 USA.
EM lisa.shay@usma.edu; gregory.conti@usma.edu; whartzog@samford.edu
NR 108
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 2158-3404
BN 978-1-4799-1242-1; 978-1-4799-0929-2
J9 INT SYMP TECHNOL SOC
PY 2013
BP 191
EP 200
PG 10
WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic
SC Computer Science; Engineering
GA BA2ZW
UT WOS:000334028200025
ER
PT J
AU Champagne, VK
Helfritch, DJ
AF Champagne, Victor K.
Helfritch, Dennis J.
TI A demonstration of the antimicrobial effectiveness of various copper
surfaces
SO JOURNAL OF BIOLOGICAL ENGINEERING
LA English
DT Article
ID BACTERIAL-CONTAMINATION; ESCHERICHIA-COLI
AB Background: Bacterial contamination on touch surfaces results in increased risk of infection. In the last few decades, work has been done on the antimicrobial properties of copper and its alloys against a range of micro-organisms threatening public health in food processing, healthcare and air conditioning applications; however, an optimum copper method of surface deposition and mass structure has not been identified. Results: A proof-of-concept study of the disinfection effectiveness of three copper surfaces was performed. The surfaces were produced by the deposition of copper using three methods of thermal spray, namely, plasma spray, wire arc spray and cold spray The surfaces were then inoculated with meticillin-resistant Staphylococcus aureus (MRSA). After a two hour exposure to the surfaces, the surviving MRSA were assayed and the results compared. The differences in the copper depositions produced by the three thermal spray methods were examined in order to explain the mechanism that causes the observed differences in MRSA killing efficiencies. The cold spray deposition method was significantly more effective than the other methods. It was determined that work hardening caused by the high velocity particle impacts created by the cold spray technique results in a copper microstructure that enhances ionic diffusion, and copper ions are principally responsible for antimicrobial activity. Conclusions: This test showed significant microbiologic differences between coatings produced by different spray techniques and demonstrates the importance of the copper application technique. The cold spray technique shows superior anti-microbial effectiveness caused by the high impact velocity imparted to the sprayed particles which results in high dislocation density and high ionic diffusivity.
C1 [Champagne, Victor K.] US Army Res Lab, Aberdeen Proving Ground, MD USA.
[Helfritch, Dennis J.] Dynam Sci, Aberdeen, MD 21001 USA.
RP Helfritch, DJ (reprint author), Dynam Sci, Aberdeen, MD 21001 USA.
EM dennis.j.helfritch.ctr@mail.mil
NR 21
TC 8
Z9 9
U1 2
U2 17
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1754-1611
J9 J BIOL ENG
JI J. Biol. Eng.
PY 2013
VL 7
IS 1
AR 8
DI 10.1186/1754-1611-7-8
PG 6
WC Biochemical Research Methods; Biotechnology & Applied Microbiology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
GA AE6JH
UT WOS:000334096700007
PM 23537176
ER
PT S
AU Theisen, BL
Kosinski, A
AF Theisen, Bernard L.
Kosinski, Andrew
BE Roning, J
Casasent, D
TI The 20TH Annual Intelligent Ground Vehicle Competition: Building a
Generation of Robotists
SO INTELLIGENT ROBOTS AND COMPUTER VISION XXX: ALGORITHMS AND TECHNIQUES
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Intelligent Robots and Computer Vision XXX - Algorithms
and Techniques
CY FEB 04-06, 2013
CL Burlingame, CA
SP Soc Imaging Sci & Technol, SPIE, Qualcomm Inc
DE intelligent robots; autonomous systems; ground vehicles; vehicle
control; engineering education; IGVC
AB The Intelligent Ground Vehicle Competition (IGVC) is one of four, unmanned systems, student competitions that were founded by the Association for Unmanned Vehicle Systems International (AUVSI). The IGVC is a multidisciplinary exercise in product realization that challenges college engineering student teams to integrate advanced control theory, machine vision, vehicular electronics and mobile platform fundamentals to design and build an unmanned system. Teams from around the world focus on developing a suite of dual-use technologies to equip ground vehicles of the future with intelligent driving capabilities. Over the past 20 years, the competition has challenged undergraduate, graduate and Ph.D. students with real world applications in intelligent transportation systems, the military and manufacturing automation. To date, teams from over 80 universities and colleges have participated. This paper describes some of the applications of the technologies required by this competition and discusses the educational benefits. The primary goal of the IGVC is to advance engineering education in intelligent vehicles and related technologies. The employment and professional networking opportunities created for students and industrial sponsors through a series of technical events over the four-day competition are highlighted. Finally, an assessment of the competition based on participation is presented.
C1 [Theisen, Bernard L.; Kosinski, Andrew] US Army TARDEC, Warren, MI 48397 USA.
RP Theisen, BL (reprint author), US Army TARDEC, 6501 E Eleven Mile Rd, Warren, MI 48397 USA.
EM bernard.theisen@us.army.mil; andrew.kosinski@us.army.mil
NR 13
TC 0
Z9 0
U1 0
U2 1
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-0-8194-9435-1
J9 PROC SPIE
PY 2013
VL 8662
AR 866203
DI 10.1117/12.2010206
PG 15
WC Engineering, Electrical & Electronic; Robotics; Optics
SC Engineering; Robotics; Optics
GA BA2ZI
UT WOS:000334022000002
ER
PT J
AU Grantner, J
Bazuin, B
Fajardo, C
Hathaway, R
Al-shawawreh, J
Dong, L
Castanier, MP
Hussain, S
AF Grantner, Janos
Bazuin, Bradley
Fajardo, Claudia
Hathaway, Richard
Al-shawawreh, Jumana
Dong, Liang
Castanier, Matthew P.
Hussain, Shabbir
GP IEEE
TI Linguistic Model for Engine Power Loss
SO PROCEEDINGS OF THE 2013 IEEE SYMPOSIUM ON COMPUTATIONAL INTELLIGENCE IN
VEHICLES AND TRANSPORTATION SYSTEMS (CIVTS)
LA English
DT Proceedings Paper
CT IEEE Symposium on Computational Intelligence in Vehicles and
Transportation Systems (CIVTS)
CY APR 16-19, 2013
CL Singapore, SINGAPORE
SP IEEE, IEEE Computat Intelligence Soc
DE Condition Based Maintenance; fuzzy model; engine power loss; intelligent
diagnostics
ID FUZZY
AB Army ground vehicles often operate in extremely severe environmental and battlefield conditions. Condition Based Maintenance (CBM) allows maintenance to be performed based on evidence of need provided by reliability modeling and/or other enabling technologies, thus reducing maintenance costs and increasing vehicle availability. A Takagi-Sugeno fuzzy model is developed to diagnose the loss of engine power of light trucks. Baseline data are acquired through engine performance measurements. The Adaptive Neuro-Fuzzy (ANFIS) training method is used to extract the fuzzy rules. To improve the quality of the model a combination of the least-square error and the backpropagation gradient descent methods is implemented to minimize the errors.
C1 [Grantner, Janos; Bazuin, Bradley] Western Michigan Univ, Dept Elect & Comp Engn, Kalamazoo, MI 49008 USA.
[Fajardo, Claudia; Hathaway, Richard] Western Michigan Univ, Dept Aeronaut & Mech Engn, Kalamazoo, MI 49008 USA.
[Dong, Liang] Baylor Univ, Baytown, TX USA.
[Castanier, Matthew P.; Hussain, Shabbir] US Army RDECOM TARDEC, Warren, MI 48397 USA.
RP Grantner, J (reprint author), Western Michigan Univ, Dept Elect & Comp Engn, Kalamazoo, MI 49008 USA.; Grantner, J (reprint author), Western Michigan Univ, Dept Aeronaut & Mech Engn, Kalamazoo, MI 49008 USA.
EM janos.grantner@wmich.edu; matt.castanier@us.army.mil
FU U.S. Army TARDEC [W56HZV-08-C-0236]; Mississippi State University
FX This material is based, in part, upon work supported by the U.S. Army
TARDEC under Contract No. W56HZV-08-C-0236, through a subcontract with
Mississippi State University, and was performed for the Simulation Based
Reliability and Safety (SimBRS) research program. UNCLASSIFIED: Dist A.
Approved for public release.
NR 6
TC 0
Z9 0
U1 0
U2 1
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4673-5913-9
PY 2013
BP 80
EP 86
PG 7
WC Automation & Control Systems; Computer Science, Artificial Intelligence;
Engineering, Electrical & Electronic; Transportation Science &
Technology
SC Automation & Control Systems; Computer Science; Engineering;
Transportation
GA BA2TR
UT WOS:000333897600012
ER
PT J
AU Gupta, A
Spryn, M
Kim, B
Edwards, E
Brantley, C
Ruffin, P
AF Gupta, Anurag
Spryn, Mitchell
Kim, Bruce
Edwards, Eugene
Brantley, Christina
Ruffin, Paul
GP IEEE
TI Packaging and Sensing Platform using Opto-electronic Zinc Oxide
Nano-Heterostructure Integration
SO 2013 IEEE 63RD ELECTRONIC COMPONENTS AND TECHNOLOGY CONFERENCE (ECTC)
LA English
DT Proceedings Paper
CT IEEE 63rd Electronic Components and Technology Conference (ECTC)
CY MAY 28-31, 2013
CL Las Vegas, NV
SP IEEE, IEEE Components, Packaging & Mfg Technol Soc
ID NANOWIRES; FUNCTIONALIZATION
AB In this work we report the sensing behavior of zinc oxide/pyrenebutyric acid nano-heterostructure and subsequent packaging of the sensor. High quality zinc oxide nanowires were synthesized and appropriately characterized. Surface of zinc oxide nanowires were engineered with optically active pyrenebutyric acid. Time dependent fluorescence quenching of the nano-heterostructure was utilized as a means to establish sensing behavior in presence of p-nitrophenol analyte. Furthermore, electrical characterization of pristine and surface-engineered zinc oxide nanowire chip is also reported. Based on these findings it was determined that the synthesized nano-heterostructure was capable of sensitive detection of p-nitrophenol vapor under ambient conditions. However, successful operation and reliable data is critically dependent on the analog sensor circuit design and subsequent packaging. Herein, we demonstrate a packaging strategy for integrating the sensing chip into a complete platform. Challenges with system integration are highlighted and a possible packaging approach for high sensitivity detection is outlined.
C1 [Gupta, Anurag; Spryn, Mitchell; Kim, Bruce] Univ Alabama, Tuscaloosa, AL 35487 USA.
[Edwards, Eugene; Brantley, Christina; Ruffin, Paul] US Army, AMRDEC, RDECOM, Redstone Arsenal, AL 35898 USA.
RP Gupta, A (reprint author), Univ Alabama, Tuscaloosa, AL 35487 USA.
EM anuragg@ieee.org
FU U. S. Army [W31P4Q-09-D-0028]; AMRDEC in Huntsville, AL
FX This work was partially funded by U. S. Army Contract No.
W31P4Q-09-D-0028, AMRDEC in Huntsville, AL.
NR 24
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4799-0233-0
PY 2013
BP 2271
EP 2275
PG 5
WC Engineering, Electrical & Electronic
SC Engineering
GA BA1ON
UT WOS:000332764900357
ER
PT J
AU Stelle, LJ
Hargrave, ML
AF Stelle, Lenville J.
Hargrave, Michael L.
TI Messages in a Map: French Depictions of the 1730 Meskwaki Fort
SO HISTORICAL ARCHAEOLOGY
LA English
DT Article
AB In 1730, French and allied tribes besieged an expedient fortification hastily constructed by the Meskwaki in a small oak grove on the central Illinois prairie. Three written narratives and four maps produced by the French shortly after the battle agree in many ways, but the maps differ dramatically in how they depict the fort's geometry. The one produced in New Orleans and showing an irregularly shaped fortification corresponds most closely to the archaeological deposits revealed by a magnetic gradient survey and ground-truthing excavations. Multiple lines of evidence converge to force the conclusion that 11ML6 is the location of the 1730 fortification. More broadly, several factors are discussed that may help account for the confusing variations observed among the four maps, including cultural and professional biases, motives of personal aggrandizement, and differences in the maps' intended functions and stages of refinement.
C1 [Stelle, Lenville J.] Parkland Coll, Dept Social Sci, Champaign, IL 61821 USA.
[Hargrave, Michael L.] ERDC CERL, Champaign, IL 61826 USA.
RP Stelle, LJ (reprint author), Parkland Coll, Dept Social Sci, 2400 West Bradley Ave, Champaign, IL 61821 USA.
NR 47
TC 0
Z9 0
U1 0
U2 5
PU SOC HISTORICAL ARCHAEOLOGY
PI ROCKVILLE
PA 9707 KEY WEST AVENUE, STE 100, ROCKVILLE, MD 20850 USA
SN 0440-9213
J9 HIST ARCHAEOL
JI Hist. Archaeol.
PY 2013
VL 47
IS 4
BP 23
EP 44
PG 22
WC Archaeology
SC Archaeology
GA AE1JY
UT WOS:000333726800002
ER
PT B
AU Biddle, J
Brigada, D
Lapadula, A
Buller, M
Mullen, S
AF Biddle, Jason
Brigada, David
Lapadula, Anthony
Buller, Mark
Mullen, Stephen
GP IEEE
TI OBAN: An Open Architecture Prototype for a Tactical Body Sensor Network
SO 2013 IEEE INTERNATIONAL CONFERENCE ON BODY SENSOR NETWORKS (BSN)
LA English
DT Proceedings Paper
CT IEEE International Conference on Body Sensor Networks
CY MAY 06-09, 2013
CL MIT Media Lab, Cambridge, MA
SP IEEE
HO MIT Media Lab
DE body sensor network; open systems architecture
AB Dismounted warfighters face a variety of environmental and physical challenges that can degrade performance and lead to serious injury. Real-time monitoring of physiological status can be a key component of reducing these risks. To these ends, a Real-Time Physiological Status Monitoring (RT-PSM) system named OBAN (Open Body Area Network) is being developed. This system utilizes an Open Systems Architecture approach which will allow for the inclusion of new sensor modalities and display form factors at low cost. A prototype has been built using both Commercial-Off-The-Shelf (COTS) and custom-designed sensors to demonstrate the feasibility of this approach. The current system accepts heart rate data from a commercial sensor to calculate the subject's Physiological Strain Index (PSI), which is an indication of susceptibility to heat injury, and data from custom, boot-mounted load sensors. COTS components were adapted to create the system's networking and computational modules. Limitations of the existing prototype are described and a path forward addressing the operational needs of warfighters is proposed.
C1 [Biddle, Jason; Brigada, David; Lapadula, Anthony] MIT, Lincoln Lab, 244 Wood St, Lexington, MA 02173 USA.
[Buller, Mark; Mullen, Stephen] US Army, Environm Med Res Inst, Natick, MA 01760 USA.
RP Lapadula, A (reprint author), MIT, Lincoln Lab, 244 Wood St, Lexington, MA 02173 USA.
EM jbiddle@ll.mit.edu; david.brigada@ll.mit.edu;
anthony.lapadula@ll.mit.edu; mark.j.buller@us.army.mil;
stephen.mullen@us.army.mil
FU United States Army Research Institute of Environmental Medicine under
Air Force [FA8721-05-C-0002]; USARIEM
FX This work is sponsored by the United States Army Research Institute of
Environmental Medicine under Air Force Contract #FA8721-05-C-0002. The
views expressed are those of the authors and do not reflect the official
policy of the Department of Army, Department of Defense, or the U.S.
Government.; We would like to thank Dr. Reed Hoyt of USARIEM for his
support of this project. We are also grateful to the entire OBAN
development team at MIT Lincoln Laboratory.
NR 12
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4799-0330-6; 978-1-4799-0331-3
PY 2013
PG 6
WC Engineering, Biomedical; Engineering, Electrical & Electronic
SC Engineering
GA BA2DO
UT WOS:000333337600065
ER
PT B
AU Clements, CM
Moody, D
Potter, AW
Seay, JF
Fellin, RE
Buller, MJ
AF Clements, Cynthia M.
Moody, Derek
Potter, Adam W.
Seay, Joseph F.
Fellin, Rebecca E.
Buller, Mark J.
GP IEEE
TI Loaded and Unloaded Foot Movement Differentiation Using Chest Mounted
Accelerometer Signatures
SO 2013 IEEE INTERNATIONAL CONFERENCE ON BODY SENSOR NETWORKS (BSN)
LA English
DT Proceedings Paper
CT IEEE International Conference on Body Sensor Networks
CY MAY 06-09, 2013
CL MIT Media Lab, Cambridge, MA
SP IEEE
HO MIT Media Lab
ID WALKING; PREDICTION; SIMULATION; HEAT; COST
AB Heavy loads often subject foot soldiers and first-responders to increased risk musculoskeletal injury (MSI). Identifying excessive loads in real-time could help identify when soldiers are at greater risk of MSI. Using Principal Component Analysis (PCA) we derived a loaded (>35 kg) versus unloaded Naive Bayesian classification model from 22 male Soldiers (age 20 +/- 3.5 yrs, height 1.76 +/- 0.09 m and weight 83 +/- 13 kg). Using seven-fold cross validation we demonstrated that using only one feature our model accurately classifies heavily loaded versus unloaded over 90% of the time. This technique lends itself to use in real time accelerometry sensors and shows promise for more complex gait analysis.
C1 [Clements, Cynthia M.; Moody, Derek; Potter, Adam W.; Seay, Joseph F.; Fellin, Rebecca E.; Buller, Mark J.] US Army, Environm Med Res Inst, Natick, MA 01760 USA.
RP Clements, CM (reprint author), US Army, Environm Med Res Inst, Natick, MA 01760 USA.
NR 20
TC 0
Z9 0
U1 0
U2 1
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4799-0330-6; 978-1-4799-0331-3
PY 2013
PG 5
WC Engineering, Biomedical; Engineering, Electrical & Electronic
SC Engineering
GA BA2DO
UT WOS:000333337600068
ER
PT B
AU Gribok, A
Rumpler, W
Hoyt, R
Buller, M
AF Gribok, Andrei
Rumpler, William
Hoyt, Reed
Buller, Mark
GP IEEE
TI Functional regression for data fusion and indirect measurements of
physiological variables collected by wearable sensor systems and
indirect calorimetry
SO 2013 IEEE INTERNATIONAL CONFERENCE ON BODY SENSOR NETWORKS (BSN)
LA English
DT Proceedings Paper
CT IEEE International Conference on Body Sensor Networks
CY MAY 06-09, 2013
CL MIT Media Lab, Cambridge, MA
SP IEEE
HO MIT Media Lab
DE functional regression; inference; smoothing; wearable sensors
AB The paper describes application of different types of functional regression for analysis and modeling of the data collected by wearable sensor systems. The data have been recorded from human subjects while they were staying in whole room calorimeter chamber for 48 hours. This allowed very accurate measurements of their oxygen consumption, energy expenditure and substrate oxidation. These physiological parameters are notorious for their inaccuracy when measured in field conditions. The subjects wore two types of body sensors: the Hidalgo Equivital (TM) (Cambridge, UK) physiological monitors with a telemetry thermometer pill and iPro Professional Continuous Glucose Monitoring System (CGMS) (Medtronic MiniMed, Inc, Northridge, CA). The data collected by these two systems and by the calorimeter chamber were subsequently analyzed off-line using the functional regression techniques. The energy expenditure, substrate oxidation, and body core temperature were used as response variables, while heart rate, respiratory rate, subcutaneous glucose concentration, and skin temperature were used as predictors. The results show that the 24-hours and instantaneous energy expenditure values can be inferred from instantaneous measurements of heart rate, respiratory rate and glucose concentrations. Also, the body core temperature can be inferred from heart rate, respiratory rate, glucose concentration, and skin temperature. The substrate oxidation was the most difficult parameter to infer and it can only be accomplished during the exercise activity.
C1 [Gribok, Andrei; Rumpler, William] USDA ARS, Beltsville Human Nutr Res Ctr, Food Components & Hlth Lab, Beltsville, MD 20705 USA.
[Hoyt, Reed; Buller, Mark] US Army, Inst Environm Med, Biophys & Biomed Modeling Div, Natick, MA 01760 USA.
RP Gribok, A (reprint author), USDA ARS, Beltsville Human Nutr Res Ctr, Food Components & Hlth Lab, Beltsville, MD 20705 USA.
FU Defense Medical Research and Development Program (DMRDP)
FX This work has been funded by Defense Medical Research and Development
Program (DMRDP) Advanced Technology Development Research Award
NR 8
TC 0
Z9 0
U1 0
U2 2
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4799-0330-6; 978-1-4799-0331-3
PY 2013
PG 6
WC Engineering, Biomedical; Engineering, Electrical & Electronic
SC Engineering
GA BA2DO
UT WOS:000333337600008
ER
PT B
AU Williamson, JR
Fischl, K
Dumas, A
Hess, A
Hughes, T
Buller, MJ
AF Williamson, James R.
Fischl, Kate
Dumas, Andrew
Hess, Austin
Hughes, Tadd
Buller, Mark J.
GP IEEE
TI Individualized Detection of Ambulatory Distress in the Field using
Wearable Sensors
SO 2013 IEEE INTERNATIONAL CONFERENCE ON BODY SENSOR NETWORKS (BSN)
LA English
DT Proceedings Paper
CT IEEE International Conference on Body Sensor Networks
CY MAY 06-09, 2013
CL MIT Media Lab, Cambridge, MA
SP IEEE
HO MIT Media Lab
DE musculoskeletal injury; gait analysis; gait asymmetry; accelerometry;
load carriage; feature extraction
AB The early onset of musculoskeletal injury during ambulation may be detectable due to changes in gait. Body worn accelerometers provide the ability for real-time monitoring and detection of these changes, thereby providing a means for avoiding further injury. We propose algorithms for extracting magnitude and pattern asymmetry features from accelerometers attached to each foot. By registering simultaneous acceleration differences between the two feet, these features provide robustness to a variety of confounding factors, such as changes in walking speed and load carriage. By computing only summary statistics from the acceleration signals, the algorithms can be easily implemented in real-time physiological status monitoring systems. We evaluate the algorithms on a field collection consisting of 32 subjects completing a series of 5 km marches under different loading conditions. We show that changes in the magnitude and pattern asymmetry features are predictive of subject ratings of physical pain and discomfort.
C1 [Williamson, James R.; Fischl, Kate; Dumas, Andrew; Hess, Austin; Hughes, Tadd] MIT, Lincoln Lab, 244 Wood St, Lexington, MA 02173 USA.
[Buller, Mark J.] US Army, Environm Med Res Inst, Natick, MA USA.
RP Williamson, JR (reprint author), MIT, Lincoln Lab, 244 Wood St, Lexington, MA 02173 USA.
FU United States Army Research Institute of Environmental Medicine under
United States Air Force [FA8721- 05-C-0002]
FX This work was sponsored by the United States Army Research Institute of
Environmental Medicine under United States Air Force Contract FA8721-
05-C-0002. Opinions, interpretations, conclusions, and recommendations
are those of the author and are not necessarily endorsed by the United
States Government.
NR 8
TC 0
Z9 0
U1 0
U2 3
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4799-0330-6; 978-1-4799-0331-3
PY 2013
PG 6
WC Engineering, Biomedical; Engineering, Electrical & Electronic
SC Engineering
GA BA2DO
UT WOS:000333337600071
ER
PT J
AU Wright, KM
Cabrera, OA
Adler, AB
Bliese, PD
AF Wright, Kathleen M.
Cabrera, Oscar A.
Adler, Amy B.
Bliese, Paul D.
TI Functional Impairment as a Variable in Adjustment Post-Combat
SO MILITARY PSYCHOLOGY
LA English
DT Article
DE anger/aggression; depression; functional impairment; postcombat
recovery; posttraumatic stress disorder
ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; PRIMARY-CARE;
IRAQ WAR; SOLDIERS; MODELS; MILITARY; TRAJECTORIES; PREVALENCE;
IMPUTATION
AB This study examined how functional impairment relates to postcombat adjustment over time, controlling for the influence of combat exposure. Analyses used sequential random coefficient models to examine 2 hypotheses: a) combat exposure and functional impairment predict the change in posttraumatic stress, depression, and anger/aggression symptoms during the first year postcombat; and b) combat exposure and functional impairment at reintegration predict symptom scores at 1 year postdeployment. A Brigade Combat Team completed surveys at reintegration, 4 months, and 12 months after a 1-year deployment to Iraq. Soldiers reporting high functional impairment at reintegration had higher symptoms at both follow-up periods, and functional impairment was a significant predictor of symptoms at the last time point, even after accounting for the influence of combat exposure. There was also an interaction effect, such that functional impairment exacerbated the impact of combat exposure on posttraumatic stress and anger/aggression symptoms at 12 months postdeployment.
C1 [Wright, Kathleen M.; Adler, Amy B.] Walter Reed Army Inst Res, Heidelberg, Germany.
[Cabrera, Oscar A.; Bliese, Paul D.] Walter Reed Army Inst Res, Silver Spring, MD USA.
RP Cabrera, OA (reprint author), US Army Combat Readiness Safety Ctr, Ft Rucker, AL 36362 USA.
EM oscar.a.cabrera2.mil@mail.mil
NR 30
TC 2
Z9 2
U1 2
U2 4
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0899-5605
EI 1532-7876
J9 MIL PSYCHOL
JI Milit. Psychol.
PY 2013
VL 25
IS 6
BP 545
EP 556
DI 10.1037/mil0000018
PG 12
WC Psychology, Multidisciplinary
SC Psychology
GA AD9MT
UT WOS:000333589900002
ER
PT J
AU Foran, HM
Adler, AB
AF Foran, Heather M.
Adler, Amy B.
TI Trainee Perceptions of Drill Sergeant Qualities During Basic Combat
Training
SO MILITARY PSYCHOLOGY
LA English
DT Article
DE military; basic training; depression; anxiety symptoms; leadership
ID MENTAL-HEALTH PROBLEMS; UNIT EFFECTIVENESS; PTSD SYMPTOMS; LEADERSHIP;
DEPRESSION; SOLDIERS; RECRUITS; ANXIETY; STRESS; NAVY
AB Basic combat training plays an important role in military service with approximately 72,000 soldiers participating in the United States annually. Although Drill Sergeant qualities have been widely portrayed in popular media, there is very little empirical research that documents the characteristics of Drill Sergeants and the impact these characteristics may have on trainees. In this study we evaluated a measure of perceived Drill Sergeant qualities and the degree to which these qualities related to mental health symptoms and job-related outcomes of trainees. Three types of perceived Drill Sergeant qualities were found from factor analyses: motivation, respect, and toughness. Using latent growth curve analyses, higher initial scores on motivation and respect, but not toughness, were associated with greater decreases in mental health symptoms over time. Further, changes in perceived Drill Sergeant qualities related to changes in depressive symptoms, unit cohesion, and citizen behaviors assessed over the course of basic combat training.
C1 [Foran, Heather M.; Adler, Amy B.] Walter Reed Army Inst Res, US Army Med Res Unit Europe, Sambach, Germany.
[Foran, Heather M.] Tech Univ Carolo Wilhelmina Braunschweig, Braunschweig, Germany.
RP Foran, HM (reprint author), US Army Med Res Unit Europe, APO, AE 09136 USA.
EM heatherforan@gmail.com
NR 38
TC 3
Z9 3
U1 1
U2 2
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0899-5605
EI 1532-7876
J9 MIL PSYCHOL
JI Milit. Psychol.
PY 2013
VL 25
IS 6
BP 577
EP 587
DI 10.1037/mil0000023
PG 11
WC Psychology, Multidisciplinary
SC Psychology
GA AD9MT
UT WOS:000333589900005
ER
PT J
AU Gallus, JA
Walsh, BM
van Driel, M
Gouge, MC
Antolic, E
AF Gallus, Jessica A.
Walsh, Benjamin M.
van Driel, Marinus
Gouge, Melissa C.
Antolic, Emily
TI Intolerable Cruelty: A Multilevel Examination of the Impact of Toxic
Leadership on US Military Units and Service Members
SO MILITARY PSYCHOLOGY
LA English
DT Article
DE toxic leadership; climate; civility; incivility; command climate
ID TRICKLE-DOWN MODEL; ABUSIVE SUPERVISION; INTERRATER RELIABILITY;
JOB-SATISFACTION; RESPONSE BIAS; ORGANIZATIONS; CLIMATE; ENVIRONMENTS;
PERSONALITY; FOLLOWERS
AB We examined the effects of toxic leadership on unit and employee outcomes. Based on Bandura's social learning theory (1977), we predicted that toxic leadership would have a direct impact on unit civility and that unit civility would mediate the relationship between toxic leadership and job satisfaction and organizational commitment. We also predicted that within-unit variability in perceptions of toxic leadership, or toxic leadership congruence, would moderate these effects such that the relationship between toxic leadership and unit and employee outcomes would be stronger when unit members had similar perceptions of their leader's engagement in toxic behavior. Results indicate that toxic leadership behavior is negatively related to unit civility and that unit civility mediates the relationship between toxic leadership and job satisfaction and organizational commitment. Contrary to expectations, toxic leadership congruence did not moderate any of the effects of toxic leadership behavior. Implications for research and practice are discussed.
C1 [Gallus, Jessica A.] US Army, Res Inst Behav & Social Sci, Ft Belvoir, VA 22060 USA.
[Walsh, Benjamin M.] Univ Illinois Springield, Dept Management, Springfield, IL USA.
[van Driel, Marinus] Van Driel Consulting, Satellite Beach, FL USA.
[Gouge, Melissa C.] George Mason Univ, Dept Sociol & Anthropol, Consortium Fellows Res Program, Fairfax, VA 22030 USA.
[Antolic, Emily] George Mason Univ, Dept Psychol, Consortium Fellows Res Program, Fairfax, VA 22030 USA.
RP Gallus, JA (reprint author), US Army, Res Inst Behav & Social Sci, Fdn Sci Res Unit, 6000 6th St, Ft Belvoir, VA 22060 USA.
EM jessica.gallus@gmail.com
NR 54
TC 0
Z9 0
U1 5
U2 14
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0899-5605
EI 1532-7876
J9 MIL PSYCHOL
JI Milit. Psychol.
PY 2013
VL 25
IS 6
BP 588
EP 601
DI 10.1037/mil0000022
PG 14
WC Psychology, Multidisciplinary
SC Psychology
GA AD9MT
UT WOS:000333589900006
ER
PT J
AU Mell, P
Harang, R
AF Mell, Peter
Harang, Richard
GP IEEE
TI Limitations to Threshold Random Walk Scan Detection and Mitigating
Enhancements
SO 2013 IEEE CONFERENCE ON COMMUNICATIONS AND NETWORK SECURITY (CNS)
LA English
DT Proceedings Paper
CT 1st IEEE International Conference on Communications and Network Security
(CNS)
CY OCT 14-16, 2013
CL Washington, DC
SP IEEE, VeriSign Corp, Virginia Techs Hume Ctr
DE Intrusion Detection; Scanning
AB This paper discusses limitations in one of the most widely cited single source scan detection algorithms: threshold random walk (TRW). If an attacker knows that TRW is being employed, these limitations enable full circumvention allowing undetectable high speed full horizontal and vertical scanning of target networks from a single Internet Protocol address. To mitigate the discovered limitations, we provide 3 enhancements to TRW and analyze the increased cost in computational complexity and memory. Even with these mitigations in place, circumvention is still possible but only through collaborative scanning (something TRW was not designed to detect) with a significant increase in the required level of effort and usage of resources.
C1 [Mell, Peter] NIST, Gaithersburg, MD 20899 USA.
[Harang, Richard] US Army, Res Lab, Adelphi, MD USA.
RP Mell, P (reprint author), NIST, Gaithersburg, MD 20899 USA.
EM peter.mell@nist.gov; richard.e.harang.ctr@mail.mil
NR 11
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4799-0895-0
PY 2013
BP 332
EP 340
PG 9
WC Computer Science, Hardware & Architecture; Computer Science, Theory &
Methods; Telecommunications
SC Computer Science; Telecommunications
GA BA1QL
UT WOS:000332881600038
ER
PT B
AU Cox, MS
AF Cox, Marcus S.
BA Cox, MS
BF Cox, MS
TI SEGREGATED SOLDIERS MILITARY TRAINING AT HISTORICALLY BLACK COLLEGES IN
THE JIM CROW SOUTH INTRODUCTION
SO SEGREGATED SOLDIERS: MILITARY TRAINING AT HISTORICALLY BLACK COLLEGES IN
THE JIM CROW SOUTH
LA English
DT Editorial Material; Book Chapter
C1 US Army, Adelphi, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LOUISIANA STATE UNIV PRESS
PI BATON ROUGE
PA BATON ROUGE, LA 70803 USA
BN 978-0-8071-5177-8; 978-0-8071-5176-1
PY 2013
BP 1
EP +
PG 10
WC History
SC History
GA BA0GE
UT WOS:000331137900003
ER
EF