FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Fan, Y
Lou, J
Garcia, C
Zhai, W
Dong, J
Wen, W
Conrad, F
Brown, J
Skerry, J
Smith, TJ
Smith, LA
Marks, JD
AF Fan, Y.
Lou, J.
Garcia, C.
Zhai, W.
Dong, J.
Wen, W.
Conrad, F.
Brown, J.
Skerry, J.
Smith, T. J.
Smith, L. A.
Marks, J. D.
TI Monoclonal antibodies against botulinum neurotoxin serotype F
SO TOXICON
LA English
DT Meeting Abstract
CT 7th International Conference on Basic and Therapeutic Aspects of
Botulinum and Tetanus Toxins (TOXINS)
CY OCT 02-05, 2011
CL Santa Fe, NM
C1 [Fan, Y.; Lou, J.; Garcia, C.; Zhai, W.; Dong, J.; Wen, W.; Conrad, F.; Marks, J. D.] Univ Calif San Francisco, Dept Anesthesia, San Francisco Gen Hosp, San Francisco, CA 94143 USA.
[Brown, J.; Skerry, J.; Smith, T. J.] USA, Med Res Inst Infect Dis, Integrated Toxinol Div, Ft Detrick, MD 21702 USA.
[Smith, L. A.] USA, Med Res & Mat Command, Ft Detrick, MD USA.
EM fanf@anesthesia.ucsf.edu
NR 0
TC 0
Z9 0
U1 0
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0041-0101
J9 TOXICON
JI Toxicon
PD JUN 15
PY 2013
VL 68
BP 85
EP 86
DI 10.1016/j.toxicon.2012.07.079
PG 2
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA 159VN
UT WOS:000320075500067
ER
PT J
AU Garcia, C
Yan, S
Geren, I
Lou, J
Wen, W
Conrad, F
Smith, TJ
Brown, J
Skerry, J
Smith, LA
Marks, JD
AF Garcia, C.
Yan, S.
Geren, I.
Lou, J.
Wen, W.
Conrad, F.
Smith, T. J.
Brown, J.
Skerry, J.
Smith, L. A.
Marks, J. D.
TI Human monoclonal antibodies binding botulinum neurotoxin types C, D, and
mosaic neurotoxins C-D and D-C
SO TOXICON
LA English
DT Meeting Abstract
CT 7th International Conference on Basic and Therapeutic Aspects of
Botulinum and Tetanus Toxins (TOXINS)
CY OCT 02-05, 2011
CL Santa Fe, NM
C1 [Garcia, C.; Yan, S.; Geren, I.; Lou, J.; Wen, W.; Conrad, F.; Marks, J. D.] Univ Calif San Francisco, Dept Anesthesia, San Francisco, CA 94143 USA.
[Smith, T. J.] USA, Med Res Inst Infect Dis, Integrated Toxinol Div, Ft Detrick, MD 21702 USA.
[Brown, J.; Skerry, J.; Smith, L. A.] USA, Med Res & Mat Command, Ft Detrick, MD USA.
EM garciamc@anesthesia.ucsf.edu
NR 0
TC 0
Z9 0
U1 1
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0041-0101
J9 TOXICON
JI Toxicon
PD JUN 15
PY 2013
VL 68
BP 86
EP 87
DI 10.1016/j.toxicon.2012.07.082
PG 2
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA 159VN
UT WOS:000320075500070
ER
PT J
AU Lyman, ME
Tuznik, KM
McNutt, P
AF Lyman, M. E.
Tuznik, K. M.
McNutt, P.
TI Methods to produce, culture and evaluate embryonic stem-cell-derived
neurons as a research tool for botulinum toxin and the black widow
spider venom latrotoxin
SO TOXICON
LA English
DT Meeting Abstract
CT 7th International Conference on Basic and Therapeutic Aspects of
Botulinum and Tetanus Toxins (TOXINS)
CY OCT 02-05, 2011
CL Santa Fe, NM
C1 [Lyman, M. E.; Tuznik, K. M.; McNutt, P.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
EM megan.lyman1@us.army.mil
NR 0
TC 0
Z9 0
U1 0
U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0041-0101
J9 TOXICON
JI Toxicon
PD JUN 15
PY 2013
VL 68
BP 91
EP 91
DI 10.1016/j.toxicon.2012.07.093
PG 1
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA 159VN
UT WOS:000320075500081
ER
PT J
AU Shoemaker, CB
Mukherjee, J
Tremblay, JM
Leysath, C
Bedenice, D
Feng, X
Ofori, K
Baldwin, K
Webb, RP
Wright, PM
Smith, LA
Tzipori, S
AF Shoemaker, C. B.
Mukherjee, J.
Tremblay, J. M.
Leysath, C.
Bedenice, D.
Feng, X.
Ofori, K.
Baldwin, K.
Webb, R. P.
Wright, P. M.
Smith, L. A.
Tzipori, S.
TI A Strategy for rapid development and simplified production of
therapeutic antitoxins tested on botulinum neurotoxin
SO TOXICON
LA English
DT Meeting Abstract
CT 7th International Conference on Basic and Therapeutic Aspects of
Botulinum and Tetanus Toxins (TOXINS)
CY OCT 02-05, 2011
CL Santa Fe, NM
C1 [Shoemaker, C. B.; Mukherjee, J.; Tremblay, J. M.; Bedenice, D.; Feng, X.; Ofori, K.; Baldwin, K.; Tzipori, S.] Tufts Univ, Cummings Sch Vet Med, Dept Biomed Sci, North Grafton, MA USA.
[Leysath, C.] NIH, Lab Bacterial Dis, Bethesda, MD 20892 USA.
[Webb, R. P.; Wright, P. M.; Smith, L. A.] USA, Med Res Inst Infect Dis, Frederick, MD USA.
EM charles.shoemaker@tufts.edu
NR 0
TC 0
Z9 0
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0041-0101
J9 TOXICON
JI Toxicon
PD JUN 15
PY 2013
VL 68
BP 97
EP 97
DI 10.1016/j.toxicon.2012.07.107
PG 1
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA 159VN
UT WOS:000320075500095
ER
PT J
AU Sun, Z
Lou, J
Cheng, L
Smith, TJ
Dong, J
Wen, W
Conrad, F
Garcia, C
Fan, Y
Henderson, T
Brown, J
Skerry, J
Smith, LA
Harrison, T
D'Andrea, A
Tomic, M
Marks, JD
AF Sun, Z.
Lou, J.
Cheng, L.
Smith, T. J.
Dong, J.
Wen, W.
Conrad, F.
Garcia, C.
Fan, Y.
Henderson, T.
Brown, J.
Skerry, J.
Smith, L. A.
Harrison, T.
D'Andrea, A.
Tomic, M.
Marks, J. D.
TI Comparison of neutralizing abilities of human monoclonal antibodies
binding different epitopes on botulinum neurotoxin A
SO TOXICON
LA English
DT Meeting Abstract
CT 7th International Conference on Basic and Therapeutic Aspects of
Botulinum and Tetanus Toxins (TOXINS)
CY OCT 02-05, 2011
CL Santa Fe, NM
C1 [Sun, Z.; Lou, J.; Dong, J.; Wen, W.; Conrad, F.; Garcia, C.; Fan, Y.; Marks, J. D.] Univ Calif San Francisco, Dept Anesthesia, San Francisco, CA 94143 USA.
[Cheng, L.; Henderson, T.] ARS, Western Reg Res Ctr, USDA, Albany, CA USA.
[Brown, J.; Skerry, J.] USA, Med Inst Infect Dis, Integrated Toxinol Div, Ft Detrick, MD USA.
[Smith, T. J.; Smith, L. A.] USA, Med Res & Mat Command, Ft Detrick, MD USA.
[Harrison, T.; D'Andrea, A.] SRI Int Biosci, Menlo Pk, CA USA.
[Tomic, M.] XOMA LLC, Berkeley, CA USA.
EM sunz@anesthesia.ucsf.edu
NR 0
TC 0
Z9 0
U1 0
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0041-0101
J9 TOXICON
JI Toxicon
PD JUN 15
PY 2013
VL 68
BP 98
EP 99
DI 10.1016/j.toxicon.2012.07.110
PG 2
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA 159VN
UT WOS:000320075500098
ER
PT J
AU Tomic, M
Garcia, C
Lou, J
Geren, IN
Meng, Q
Conrad, F
Wen, W
Smith, TJ
Brown, J
Smith, LA
Wajid, A
Dadson, AC
Horwitz, AH
Freeberg, J
Marks, JD
AF Tomic, M.
Garcia, C.
Lou, J.
Geren, I. N.
Meng, Q.
Conrad, F.
Wen, W.
Smith, T. J.
Brown, J.
Smith, L. A.
Wajid, A.
Dadson, A. C., Jr.
Horwitz, A. H.
Freeberg, J.
Marks, J. D.
TI Recombinant monoclonal-antibody-based antitoxins for treatment of types
A, B, and E botulism
SO TOXICON
LA English
DT Meeting Abstract
CT 7th International Conference on Basic and Therapeutic Aspects of
Botulinum and Tetanus Toxins (TOXINS)
CY OCT 02-05, 2011
CL Santa Fe, NM
C1 [Tomic, M.; Wajid, A.; Dadson, A. C., Jr.; Horwitz, A. H.; Freeberg, J.] XOMA LLC, Berkeley, CA USA.
[Smith, T. J.; Brown, J.; Smith, L. A.] USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA.
[Garcia, C.; Lou, J.; Geren, I. N.; Meng, Q.; Conrad, F.; Wen, W.; Marks, J. D.] Univ Calif San Francisco, Dept Anesthesia, San Francisco Gen Hosp, San Francisco, CA 94143 USA.
EM tomic@xoma.com
NR 0
TC 0
Z9 0
U1 0
U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0041-0101
J9 TOXICON
JI Toxicon
PD JUN 15
PY 2013
VL 68
BP 99
EP 100
DI 10.1016/j.toxicon.2012.07.113
PG 2
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA 159VN
UT WOS:000320075500101
ER
PT J
AU Tuznik, KM
Lyman, ME
McNutt, PM
AF Tuznik, K. M.
Lyman, M. E.
McNutt, P. M.
TI Design and enzymatic response of engineered botulinum neurotoxin
B-insensitive VAMP-2 mutants
SO TOXICON
LA English
DT Meeting Abstract
CT 7th International Conference on Basic and Therapeutic Aspects of
Botulinum and Tetanus Toxins (TOXINS)
CY OCT 02-05, 2011
CL Santa Fe, NM
C1 [Tuznik, K. M.; Lyman, M. E.; McNutt, P. M.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
EM kaylie.tuznik@us.army.mil
NR 0
TC 0
Z9 0
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0041-0101
J9 TOXICON
JI Toxicon
PD JUN 15
PY 2013
VL 68
BP 101
EP 101
DI 10.1016/j.toxicon.2012.07.116
PG 1
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA 159VN
UT WOS:000320075500104
ER
PT J
AU Zuniga, J
Hammill, J
Drory, O
Nuss, J
Burnett, J
Gussio, R
Wipf, P
Bavari, S
Brunger, AT
AF Zuniga, J.
Hammill, J.
Drory, O.
Nuss, J.
Burnett, J.
Gussio, R.
Wipf, P.
Bavari, S.
Brunger, A. T.
TI Structural basis for the inhibition of botulinum neurotoxin serotype A
by potent peptidomimetics
SO TOXICON
LA English
DT Meeting Abstract
CT 7th International Conference on Basic and Therapeutic Aspects of
Botulinum and Tetanus Toxins (TOXINS)
CY OCT 02-05, 2011
CL Santa Fe, NM
C1 [Zuniga, J.; Drory, O.; Brunger, A. T.] Howard Hughes Med Inst, Stanford, CA USA.
[Zuniga, J.; Drory, O.; Brunger, A. T.] Stanford Univ, Stanford, CA 94305 USA.
[Hammill, J.; Wipf, P.] Univ Pittsburgh, Pittsburgh, PA USA.
[Nuss, J.; Bavari, S.] USA, Med Res Inst Infect Dis, Frederick, MD USA.
[Burnett, J.] NCI, Frederick, MD 21701 USA.
[Gussio, R.] NCI, Dev Therapeut Program, Frederick, MD 21701 USA.
EM jzuniga@stanford.edu
NR 0
TC 0
Z9 0
U1 0
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0041-0101
J9 TOXICON
JI Toxicon
PD JUN 15
PY 2013
VL 68
BP 103
EP 104
DI 10.1016/j.toxicon.2012.07.122
PG 2
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA 159VN
UT WOS:000320075500110
ER
PT J
AU Alvarez, MV
Grogan, PM
AF Alvarez, M. V.
Grogan, P. M.
TI Is there a role for rimabotulinumtoxinB In the treatment of
medication-resistant low back pain?
SO TOXICON
LA English
DT Meeting Abstract
CT 7th International Conference on Basic and Therapeutic Aspects of
Botulinum and Tetanus Toxins (TOXINS)
CY OCT 02-05, 2011
CL Santa Fe, NM
C1 [Alvarez, M. V.] Ctr Neurol Care & Res, San Antonio, TX USA.
[Grogan, P. M.] Brooke Army Med Ctr, Dept Neurol, Ft Sam Houston, TX 78234 USA.
EM vikki.alvarez@yahoo.com
NR 0
TC 0
Z9 0
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0041-0101
J9 TOXICON
JI Toxicon
PD JUN 15
PY 2013
VL 68
BP 104
EP 105
DI 10.1016/j.toxicon.2012.07.125
PG 2
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA 159VN
UT WOS:000320075500113
ER
PT J
AU Bland, CM
Tritsch, AM
Bookstaver, DA
Sweeney, LB
Wiley, D
Choi, YU
AF Bland, Christopher M.
Tritsch, Adam M.
Bookstaver, David A.
Sweeney, Lori B.
Wiley, Dan
Choi, Yong U.
TI Hypertension and diabetes mellitus medication management in sleeve
gastrectomy patients
SO AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
LA English
DT Editorial Material
ID BARIATRIC SURGERY; OBESITY
C1 [Bland, Christopher M.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA.
[Bland, Christopher M.; Wiley, Dan] Univ Georgia, Coll Pharm, Athens, GA 30602 USA.
RP Bland, CM (reprint author), Dwight D Eisenhower Army Med Ctr, Hosp Rd Bldg 300, Ft Gordon, GA 30905 USA.
EM chris.bland@us.army.mil
NR 13
TC 2
Z9 3
U1 0
U2 5
PU AMER SOC HEALTH-SYSTEM PHARMACISTS
PI BETHESDA
PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 USA
SN 1079-2082
J9 AM J HEALTH-SYST PH
JI Am. J. Health-Syst. Pharm.
PD JUN 15
PY 2013
VL 70
IS 12
BP 1018
EP 1020
DI 10.2146/ajhp120607
PG 3
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 161SU
UT WOS:000320214400009
PM 23719877
ER
PT J
AU Herrell, R
Bliese, P
Hoge, C
AF Herrell, Richard
Bliese, Paul
Hoge, Charles
TI PTSD, DEPRESSION, AND SUICIDALITY IN A SAMPLE OF US SOLDIERS
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
C1 [Herrell, Richard; Bliese, Paul; Hoge, Charles] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
NR 0
TC 0
Z9 0
U1 0
U2 7
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 15
PY 2013
VL 177
SU 11
BP S28
EP S28
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 157BL
UT WOS:000319870300109
ER
PT J
AU Muench, SP
Stec, J
Zhou, Y
Afanador, GA
McPhillie, MJ
Hickman, MR
Lee, PJ
Leed, SE
Auschwitz, JM
Prigge, ST
Rice, DW
McLeod, R
AF Muench, Stephen P.
Stec, Jozef
Zhou, Ying
Afanador, Gustavo A.
McPhillie, Martin J.
Hickman, Mark R.
Lee, Patty J.
Leed, Susan E.
Auschwitz, Jennifer M.
Prigge, Sean T.
Rice, David W.
McLeod, Rima
TI Development of a triclosan scaffold which allows for adaptations on both
the A- and B-ring for transport peptides
SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
LA English
DT Article
DE Enoyl reductase; Triclosan; Toxoplasma; Plasmodium
ID CARRIER PROTEIN REDUCTASE; ENOYL-ACP REDUCTASE; FATTY-ACID BIOSYNTHESIS;
PLASMODIUM-FALCIPARUM; TOXOPLASMA-GONDII; ESCHERICHIA-COLI; INHIBITION;
TARGET; PARASITES; DELIVERY
AB The enoyl acyl-carrier protein reductase (ENR) enzyme is harbored within the apicoplast of apicomplexan parasites providing a significant challenge for drug delivery, which may be overcome through the addition of transductive peptides, which facilitates crossing the apicoplast membranes. The binding site of tri-closan, a potent ENR inhibitor, is occluded from the solvent making the attachment of these linkers challenging. Herein, we have produced 3 new triclosan analogs with bulky A- and B-ring motifs, which protrude into the solvent allowing for the future attachment of molecular transporters for delivery. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.
C1 [Muench, Stephen P.] Univ Leeds, Sch Biomed Sci, Leeds, W Yorkshire, England.
[Stec, Jozef] Univ Illinois, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA.
[Zhou, Ying; McLeod, Rima] Univ Chicago, Inst Genom & Syst Biol & Coll, Dept Ophthalmol & Visual Sci, Chicago, IL 60637 USA.
[Afanador, Gustavo A.; Prigge, Sean T.] Johns Hopkins Sch Publ Hlth, Baltimore, MD 21205 USA.
[McPhillie, Martin J.; Rice, David W.] Univ Sheffield, Dept Mol Biol & Biotechnol, Sheffield S10 2TN, S Yorkshire, England.
[Hickman, Mark R.; Lee, Patty J.; Leed, Susan E.; Auschwitz, Jennifer M.] Walter Reed Army Inst Res, Div Expt Therapeut, Dept Discovery, Silver Spring, MD 20910 USA.
RP Muench, SP (reprint author), Univ Leeds, Sch Biomed Sci, Leeds, W Yorkshire, England.
EM s.p.muench@leeds.ac.uk; jstec@csu.edu
OI Muench, Stephen/0000-0001-6869-4414
FU NIAID [U01 AI082180-01]; Rooney-Alden family; Taub family; Engel family;
Pritzker family; Harris family; Kapnick family; Mussilami family; Samuel
family; Mann-Cornwell Family Foundation; MRC Career Development
fellowship [G1000567]
FX We thank Dr. Alan Kozikowski for his contributions. The authors are
grateful for the financial support provided by NIAID U01 AI082180-01 and
the Rooney-Alden, Taub, Engel, Pritzker, Harris, Kapnick, Mussilami and
Samuel families and the Mann-Cornwell Family Foundation. SPM is
supported by an MRC Career Development fellowship (G1000567).
NR 37
TC 7
Z9 7
U1 0
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0960-894X
J9 BIOORG MED CHEM LETT
JI Bioorg. Med. Chem. Lett.
PD JUN 15
PY 2013
VL 23
IS 12
BP 3551
EP 3555
DI 10.1016/j.bmcl.2013.04.035
PG 5
WC Chemistry, Medicinal; Chemistry, Organic
SC Pharmacology & Pharmacy; Chemistry
GA 148ST
UT WOS:000319268500015
PM 23664871
ER
PT J
AU Mackie, DM
Liu, SC
Benyamin, M
Ganguli, R
Sumner, JJ
AF Mackie, David M.
Liu, Sanchao
Benyamin, Marcus
Ganguli, Rahul
Sumner, James J.
TI Direct utilization of fermentation products in an alcohol fuel cell
SO JOURNAL OF POWER SOURCES
LA English
DT Article
DE Proton exchange membrane fuel cell; Microbial; Ethanol; Yeast;
Fermentation; Glucose
ID POWER-GENERATION; HYDROGEN; ETHANOL; ELECTROOXIDATION; TEMPERATURE;
PERFORMANCE; OXIDATION; CATALYSTS
AB Due to energy demands and environmental concerns there has been a great interest in searching out renewable energy sources as an alternative to fossil hydrocarbons. These must also be environmentally sustainable and convenient to implement. Glucose has been proposed as a renewable energy source for several reasons including its energy density, safety, sustainability, and the ability to be scavenged from native ecosystems or from waste streams. Here we describe the use of a bio-hybrid fuel cell to oxidize the glucose to ethanol and limit parasitic power losses by using the fermented alcohol with minimal preparation in a direct alcohol fuel cell. Moving from using dilute alcohol in deionized water to the complex matrices of fermented media raises many questions about the performance and lifetime of the fuel cell and its components. These questions include but are not limited to the effects of starting materials and byproducts of the fermentations and the performance of the catalytic oxidation of ethanol at metal catalysts in batch mode. This study examines the effects of multiple components such as ionic strength, cation size, buffering strength, alcohol concentration, fermentation/fuel cell byproducts, and interfering organics on fuel cell operation. Published by Elsevier B.V.
C1 [Mackie, David M.; Liu, Sanchao; Benyamin, Marcus; Sumner, James J.] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
[Ganguli, Rahul] Teledyne Sci & Imaging LLC, Thousand Oaks, CA 91360 USA.
RP Sumner, JJ (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
EM david.m.mackie.civ@mail.mil; sanchao.liu.ctr@mail.mil;
marcus.s.benyamin.ctr@mail.mil; rganguli@teledyne-si.com;
james.j.sumner4.civ@mail.mil
FU U.S. Army's Institute of Collaborative Biotechnologies (ICB)
[W911NF-09-D-0001]; US Army Research Laboratory, Sensors and Electron
Devices Directorate (ARL-SEDD); Science and Engineering Apprenticeship
Program (SEAP)
FX The authors acknowledge funding from the U.S. Army's Institute of
Collaborative Biotechnologies (ICB) under contract number
W911NF-09-D-0001. The authors also acknowledge K. Chu for laboratory
support and D. Chu for helpful conversations as well as the support of
the US Army Research Laboratory, Sensors and Electron Devices
Directorate (ARL-SEDD). M.B. acknowledges the Science and Engineering
Apprenticeship Program (SEAP) for support. S.L. acknowledges General
Technical Services (GTS) for administrative support.
NR 20
TC 4
Z9 4
U1 2
U2 65
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-7753
J9 J POWER SOURCES
JI J. Power Sources
PD JUN 15
PY 2013
VL 232
BP 34
EP 41
DI 10.1016/j.jpowsour.2013.01.077
PG 8
WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials
Science, Multidisciplinary
SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science
GA 141UU
UT WOS:000318752800007
ER
PT J
AU Orlicki, JA
Zander, NE
Martin, GR
Kosik, WE
Demaree, JD
Leadore, JL
Rawlett, AM
AF Orlicki, Joshua A.
Zander, Nicole E.
Martin, George R.
Kosik, Wendy E.
Demaree, J. Derek
Leadore, Julia L.
Rawlett, Adam M.
TI Self-segregating hyperbranched polymer/silver nanoparticle hybrids in
thermoplastic polyurethane films
SO JOURNAL OF APPLIED POLYMER SCIENCE
LA English
DT Article
DE nanoparticles; nanowires; nanocrystals; films; dendrimers; hyperbranched
polymers; macrocycles; surfaces; interfaces
ID SILVER NANOPARTICLES; POLY(METHYL METHACRYLATE); ALIPHATIC POLYESTERS;
SURFACE SEGREGATION; BLOCK-COPOLYMERS; GOLD; DISPERSION; ADDITIVES;
COATINGS; MATRICES
AB Self-segregating hyperbranched polymer (HBP) additives have been utilized to concentrate silver nanoparticles (AgNPs) at the air interface of polyurethane films. The limited spontaneous surface migration of the AgNPs was enhanced through the addition of appropriately functionalized HBPs. Both amine and thiol terminated additives were employed to allow interaction of the HBP with the nanoparticles. Both types of additives increased surface concentration of silver modestly, though the thiol-terminated HBPs demonstrated nearly a seven-fold enhancement of surface migration. It was also found that wholly-aliphatic HBPs demonstrated only slightly reduced ability to bias AgNP concentration as compared to HBPs functionalized with perfluorinated chains. In addition, films containing 1% total silver concentration were tested for antimicrobial activity using the ASTM-E 2180 protocol. Significant reduction of the microorganisms was observed for all samples, 6-log reduction was achieved for the gram-negative bacteria P. aeruginosa, the gram-positive bacteria S. aureus, and the fungi C. albicans. (c) 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
C1 [Orlicki, Joshua A.; Zander, Nicole E.; Martin, George R.; Kosik, Wendy E.; Demaree, J. Derek; Leadore, Julia L.; Rawlett, Adam M.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Orlicki, JA (reprint author), USA, Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA.
EM joshua.a.orlicki.civ@mail.mil
FU Postgraduate Research Participation Program at the U.S. Army Research
Laboratory; Director's Research Initiative
FX This research was supported in part through an appointment to the
Postgraduate Research Participation Program at the U.S. Army Research
Laboratory administered by the Oak Ridge Institute for Science and
Education through an interagency agreement between the U.S. Department
of Energy and USARL. It was also conducted with the support from the
Director's Research Initiative. The authors would like to thank BASF and
Perstorp for their generous donation of materials.
NR 52
TC 3
Z9 3
U1 4
U2 139
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-8995
J9 J APPL POLYM SCI
JI J. Appl. Polym. Sci.
PD JUN 15
PY 2013
VL 128
IS 6
BP 4181
EP 4188
DI 10.1002/app.38620
PG 8
WC Polymer Science
SC Polymer Science
GA 113UY
UT WOS:000316696000081
ER
PT J
AU Sanchez, CJ
Ward, CL
Romano, DR
Hurtgen, BJ
Hardy, SK
Woodbury, RL
Trevino, AV
Rathbone, CR
Wenke, JC
AF Sanchez, Carlos J., Jr.
Ward, Catherine L.
Romano, Desiree R.
Hurtgen, Brady J.
Hardy, Sharanda K.
Woodbury, Ronald L.
Trevino, Alex V.
Rathbone, Christopher R.
Wenke, Joseph C.
TI Staphylococcus aureus biofilms decrease osteoblast viability, inhibits
osteogenic differentiation, and increases bone resorption in vitro
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Article
DE Biofilm; Osteoblast; Osteogenic differentiation; Staphylococcus aureus;
Receptor activator of NF-kB ligand; Osteoprotegrin
ID NECROSIS-FACTOR RECEPTOR; BACTERIAL BIOFILMS; OSTEOCLAST
DIFFERENTIATION; HUMAN KERATINOCYTES; HUMAN NEUTROPHILS; HUMAN
FIBROBLASTS; PLASMA-MEMBRANE; CHRONIC WOUNDS; STAPHOPAIN B; HOST-DEFENSE
AB Background: Osteomyelitis is a severe and often debilitating disease characterized by inflammatory destruction of bone. Despite treatment, chronic infection often develops which is associated with increased rates of treatment failure, delayed osseous-union, and extremity amputation. Within affected bone, bacteria exist as biofilms, however the impact of biofilms on osteoblasts during disease are unknown. Herein, we evaluated the effect of S. aureus biofilms on osteoblast viability, osteogenic potential, and the expression of the pro-osteoclast factor, receptor activator of NF-kB ligand (RANK-L).
Methods: Osteoblasts were exposed to biofilm conditioned media (BCM) from clinical wound isolates of Staphylococcus aureus under normal growth and osteogenic conditions to assess cellular viability and osteoblast differentiation, respectively. Cell viability was evaluated using a live/dead assay and by quantifying total cellular DNA at days 0, 1, 3, 5, and 7. Apoptosis following treatment with BCM was measured by flow-cytometry using the annexin V-FITC/PI apoptosis kit. Osteogenic differentiation was assessed by measuring alkaline phosphatase activity and intracellular accumulation of calcium and osteocalcin for up to 21 days following exposure to BCM. Expression of genes involved in osteogenic differentiation and osteoclast regulation, were also evaluated by quantitative real-time PCR.
Results: BCM from clinical strains of S. aureus reduced osteoblast viability which was accompanied by an increase in apoptosis. Osteogenic differentiation was significantly inhibited following treatment with BCM as indicated by decreased alkaline phosphatase activity, decreased intracellular accumulation of calcium and inorganic phosphate, as well as reduced expression of transcription factors and genes involved in bone mineralization in viable cells. Importantly, exposure of osteoblasts to BCM resulted in up-regulated expression of RANK-L and increase in the RANK-L/OPG ratio compared to the untreated controls.
Conclusions: Together these studies suggest that soluble factors produced by S. aureus biofilms may contribute to bone loss during chronic osteomyelitis simultaneously by: (1) reducing osteoblast viability and osteogenic potential thereby limiting new bone growth and (2) promoting bone resorption through increased expression of RANK-L by osteoblasts. To our knowledge these are the first studies to demonstrate the impact of staphylococcal biofilms on osteoblast function, and provide an enhanced understanding of the pathogenic role of staphylococcal biofilms during osteomyelitis.
C1 [Sanchez, Carlos J., Jr.; Ward, Catherine L.; Romano, Desiree R.; Hurtgen, Brady J.; Hardy, Sharanda K.; Woodbury, Ronald L.; Trevino, Alex V.; Rathbone, Christopher R.; Wenke, Joseph C.] USA, Inst Surg Res, Dept Extrem Trauma & Regenerat Med, San Antonio, TX USA.
RP Sanchez, CJ (reprint author), USA, Inst Surg Res, Dept Extrem Trauma & Regenerat Med, San Antonio, TX USA.
EM carlos.j.sanchez3@us.army.mil
FU Combat Casualty Research Program, Medical Research and Materiel Command;
Post-doctoral Research Associate Fellowship through the National Academy
of Sciences
FX This work was supported by intramural funding from the Combat Casualty
Research Program, Medical Research and Materiel Command to JCW. CJS, CLW
and BJH are supported by a Post-doctoral Research Associate Fellowship
through the National Academy of Sciences.
NR 54
TC 13
Z9 14
U1 0
U2 16
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD JUN 14
PY 2013
VL 14
AR 187
DI 10.1186/1471-2474-14-187
PG 11
WC Orthopedics; Rheumatology
SC Orthopedics; Rheumatology
GA 171HN
UT WOS:000320916000001
PM 23767824
ER
PT J
AU Smith, TJ
Rigassio-Radler, D
Denmark, R
Haley, T
Touger-Decker, R
AF Smith, Tracey J.
Rigassio-Radler, Diane
Denmark, Robert
Haley, Timothy
Touger-Decker, Riva
TI Effect of Lactobacillus rhamnosus LGG (R) and Bifidobacterium animalis
ssp lactis BB-12 (R) on health-related quality of life in college
students affected by upper respiratory infections
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Probiotics; Respiratory tract infections; Common cold; Lactobacillus;
Bifidobacterium
ID SEVERE ACUTE-PANCREATITIS; DOUBLE-BLIND; COMMON COLD; PROBIOTIC
PROPHYLAXIS; UNIVERSITY-STUDENTS; CONTROLLED-TRIAL; IMMUNE-SYSTEM; ACID
BACTERIA; MODULATION; EXERCISE
AB College students are susceptible to upper respiratory infections (URI) due to inadequate sleep, stress and close living quarters. Certain probiotic strains modulate immune function and may improve health-related quality of life (HRQL) during URI. The present study recruited apparently healthy college students and assessed the effect of probiotics on HRQL outcomes (i.e. self-reported duration, symptom severity and functional impairment of URI) in those who developed URI. Missed school and work days due to URI were also considered. Subjects (n 231) were apparently healthy college students living on campus in residence halls at the Framingham State University (Framingham, MA, USA), and were randomised to receive placebo (n 117) or probiotic-containing powder (daily dose of minimum 1 billion colony-forming units of each Lactobacillus rhamnosus LGG (R) (LGG (R)) and Bifidobacterium animalis ssp. lactis BB-12 (R) (BB-12 (R)); n 114) for 12 weeks. Subjects completed The Wisconsin Upper Respiratory Symptom Survey-21 to assess HRQL during URI. The final analyses included 198 subjects (placebo, n 97 and probiotics, n 101). The median duration of URI was significantly shorter by 2 d and median severity score was significantly lower by 34% with probiotics v. placebo (P<0.001), indicating a higher HRQL during URI. Number of missed work days was not different between groups (P=0.429); however, the probiotics group missed significantly fewer school days (mean difference = 0.2 d) compared to the placebo group (P=0.002). LGG (R) and BB-12 (R) may be beneficial among college students with URI for mitigating decrements in HRQL. More research is warranted regarding mechanisms of action associated with these findings and the cost-benefit of prophylactic supplementation.
C1 [Smith, Tracey J.; Rigassio-Radler, Diane; Touger-Decker, Riva] Univ Med & Dent New Jersey, Sch Hlth Related Profess, Dept Nutr Sci, Newark, NJ 07101 USA.
[Denmark, Robert] Univ Med & Dent New Jersey, Sch Hlth Related Profess, Dept Interdisciplinary Studies, Newark, NJ 07101 USA.
[Haley, Timothy] Univ Med & Dent New Jersey, Sch Hlth Related Profess, Adjunct Fac, Newark, NJ 07101 USA.
[Haley, Timothy] USA, Off Med Support & Oversight, Environm Med Res Inst, Natick, MA 01760 USA.
RP Smith, TJ (reprint author), Univ Med & Dent New Jersey, Sch Hlth Related Profess, Dept Nutr Sci, 65 Bergen St,Room 157, Newark, NJ 07101 USA.
EM smitht9@umdnj.edu
FU Chr Hansen A/S (Hoersholm, Denmark)
FX The present study was funded by Chr Hansen A/S (Hoersholm, Denmark). Chr
Hansen A/S provided the probiotics and placebo products, and provided
input towards the study design and final report. However, the company
had no involvement in data collection, analysis or interpretation. The
authors declare no conflicts of interest. T. J. S. designed the study,
coordinated data acquisition, performed the statistical analysis and
drafted the manuscript. D. R.-R., R. T.-D., R. D. and T. H. made
substantial contributions to study design and critically revised the
manuscript for intellectual content. The authors wish to thank study
subjects and research assistants from the Framingham State University,
Framingham, MA (USA).
NR 50
TC 12
Z9 13
U1 3
U2 23
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
J9 BRIT J NUTR
JI Br. J. Nutr.
PD JUN 14
PY 2013
VL 109
IS 11
BP 1999
EP 2007
DI 10.1017/S0007114512004138
PG 9
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA 146WT
UT WOS:000319126700009
PM 23020819
ER
PT J
AU Lu, XCM
Dave, JR
Chen, ZY
Cao, Y
Liao, ZL
Tortella, FC
AF Lu, Xi-Chun May
Dave, Jitendra R.
Chen, Zhiyong
Cao, Ying
Liao, Zhilin
Tortella, Frank C.
TI Nefiracetam attenuates post-ischemic nonconvulsive seizures in rats and
protects neuronal cell death induced by veratridine and glutamate
SO LIFE SCIENCES
LA English
DT Article
DE Brain ischemia; Nonconvulsive seizures; Nefiracetam; EEG; Veratridine;
Glutamate; Rat
ID CONVULSIVE STATUS EPILEPTICUS; NICOTINIC ACETYLCHOLINE-RECEPTORS;
SUSTAINED CEREBRAL-ISCHEMIA; NATIONWIDE INPATIENT SAMPLE; NOOTROPIC
AGENT NEFIRACETAM; TRAUMATIC BRAIN-INJURY; ANTIEPILEPTIC DRUGS;
SUBARACHNOID HEMORRHAGE; CORTICAL-NEURONS; ANTICONVULSANT
AB Aims: Stroke patients are at a high risk of developing post-ischemic seizures and cognitive impairment. Nefiracetam (NEF), a pyrrolidone derivative, has been shown to possess both anti-epileptic and cognitive-enhancing properties. In this study the anti-seizure effects of NEF were evaluated in a rat model of post-ischemic nonconvulsive seizures (NCSs). Its potential mechanisms were investigated in neuronal cell culture assays of neurotoxicity associated with ischemic brain injury and epileptogenesis.
Main methods: In the in vivo study, rats received 24 h permanent middle cerebral artery occlusion. NEF was administered intravenously either at 15 min post-injury but prior to the first NCS event (30 mg/kg, pre-NCS treatment) or immediately after the first NCS occurred (30 or 60 mg/kg, post-NCS treatment). In the in vitro study, neuronal cell cultures were exposed to veratridine or glutamate and treated with NEF (1-500 nM).
Key findings: The NEF pre-NCS treatment significantly reduced the NCS frequency and duration, whereas the higher NEF dose (60 mg/kg) was required to achieve similar effects when given after NCS occurred. The NEF treatment also dose-dependently (5-500 nM) protected against neuronal cell death induced by veratridine as measured by MTT cell viability assay, but higher doses (250-500 nM) were required against glutamate toxicity.
Significance: The anti-seizure property of NEF was demonstrated in a clinically relevant rat model of post-ischemic NCS. The preferential effects of NEF against in vitro veratridine toxicity suggest the involvement of its modulation of sodium channel malfunction. Future studies are warranted to study the mechanisms of NEF against ischemic brain injury and post-ischemic seizures. Published by Elsevier Inc.
C1 [Lu, Xi-Chun May; Dave, Jitendra R.; Chen, Zhiyong; Cao, Ying; Liao, Zhilin; Tortella, Frank C.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Branch Brain Trauma & Neuroprotect & Neurorestora, Silver Spring, MD 20910 USA.
RP Lu, XCM (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Branch Brain Trauma & Neuroprotect & Neurorestora, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM may.lu@us.army.mil
NR 35
TC 3
Z9 3
U1 1
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
J9 LIFE SCI
JI Life Sci.
PD JUN 13
PY 2013
VL 92
IS 22
BP 1055
EP 1063
DI 10.1016/j.lfs.2013.04.004
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 160AJ
UT WOS:000320088100003
PM 23603142
ER
PT J
AU Rodriguez-Santiago, V
Vargas-Gonzalez, L
Bujanda, AA
Baeza, JA
Fleischman, MS
Yim, JH
Pappas, DD
AF Rodriguez-Santiago, Victor
Vargas-Gonzalez, Lionel
Bujanda, Andres A.
Baeza, Jose A.
Fleischman, Michelle S.
Yim, Jacqueline H.
Pappas, Daphne D.
TI Modification of Silicon Carbide Surfaces by Atmospheric Pressure Plasma
for Composite Applications
SO ACS APPLIED MATERIALS & INTERFACES
LA English
DT Article
DE silicon carbide; dielectric barrier discharges; bonding; surface
modification; grit blasting
ID OXYGEN PLASMA; DISCHARGE; CERAMICS; ADHESION; POLYMERS; ALUMINA; ARMOR;
EPOXY
AB In this study, we explore the use of atmospheric pressure plasmas for enhancing the adhesion of SiC surfaces using a urethane adhesive, as an alternative to grit blasting Surface analysis showed that He-O-2 plasma treatments resulted in a hydrophilic Surface mostly by producing SiOx. Four point bending tests and bonding pull tests were carried out on control, grit-blasted, and plasma-treated surfaces. Grit-blasted samples showed enhanced bonding but also a decrease in flexural strength. Plasma treated samples did not affect the flexural strength of the material and showed an increase in bonding strength. These results suggest that atmospheric pressure plasma treatment of ceramic materials, is an effective alternative to grit blasting for adhesion enhancement.
C1 [Rodriguez-Santiago, Victor; Vargas-Gonzalez, Lionel; Bujanda, Andres A.; Baeza, Jose A.; Fleischman, Michelle S.; Yim, Jacqueline H.; Pappas, Daphne D.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Rodriguez-Santiago, V (reprint author), USA, Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA.
EM victor.rodriguez31@us.army.mil
OI Vargas-Gonzalez, Lionel/0000-0001-6500-1686; Rodriguez-Santiago,
Victor/0000-0002-8389-5414; Vargas-Gonzalez, Laura/0000-0003-1173-3704
NR 26
TC 4
Z9 4
U1 2
U2 42
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1944-8244
J9 ACS APPL MATER INTER
JI ACS Appl. Mater. Interfaces
PD JUN 12
PY 2013
VL 5
IS 11
BP 4725
EP 4730
DI 10.1021/am303227q
PG 6
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
SC Science & Technology - Other Topics; Materials Science
GA 165KY
UT WOS:000320484000034
PM 23639326
ER
PT J
AU Cywes-Bentley, C
Skurnik, D
Zaidi, T
Roux, D
DeOliveira, RB
Garrett, WS
Lu, X
O'Malley, J
Kinzel, K
Zaidi, T
Rey, A
Perrin, C
Fichorova, RN
Kayatani, AKK
Maira-Litran, T
Gening, ML
Tsvetkov, YE
Nifantiev, NE
Bakaletz, LO
Pelton, SI
Golenbock, DT
Pier, GB
AF Cywes-Bentley, Colette
Skurnik, David
Zaidi, Tanweer
Roux, Damien
DeOliveira, Rosane B.
Garrett, Wendy S.
Lu, Xi
O'Malley, Jennifer
Kinzel, Kathryn
Zaidi, Tauqeer
Rey, Astrid
Perrin, Christophe
Fichorova, Raina N.
Kayatani, Alexander K. K.
Maira-Litran, Tomas
Gening, Marina L.
Tsvetkov, Yury E.
Nifantiev, Nikolay E.
Bakaletz, Lauren O.
Pelton, Stephen I.
Golenbock, Douglas T.
Pier, Gerald B.
TI Antibody to a conserved antigenic target is protective against diverse
prokaryotic and eukaryotic pathogens
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE immunotherapy; infectious diseases; malaria; carbohydrates; animal
models
ID POLY-N-ACETYLGLUCOSAMINE; HUMAN MONOCLONAL-ANTIBODIES;
STAPHYLOCOCCUS-AUREUS; SURFACE POLYSACCHARIDE; CONJUGATE VACCINES;
UNITED-STATES; DISPERSIN-B; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS;
STREPTOCOCCUS-PNEUMONIAE; NEISSERIA-MENINGITIDIS
AB Microbial capsular antigens are effective vaccines but are chemically and immunologically diverse, resulting in a major barrier to their use against multiple pathogens. A beta-(1 -> 6)-linked poly-N-acetyl-D-glucosamine (PNAG) surface capsule is synthesized by four proteins encoded in genetic loci designated intercellular adhesion in Staphylococcus aureus or polyglucosamine in selected Gram-negative bacterial pathogens. We report that many microbial pathogens lacking an identifiable intercellular adhesion or polyglucosamine locus produce PNAG, including Gram-positive, Gram-negative, and fungal pathogens, as well as protozoa, e. g., Trichomonas vaginalis, Plasmodium berghei, and sporozoites and blood-stage forms of Plasmodium falciparum. Natural antibody to PNAG is common in humans and animals and binds primarily to the highly acetylated glycoform of PNAG but is not protective against infection due to lack of deposition of complement opsonins. Polyclonal animal antibody raised to deacetylated glycoforms of PNAG and a fully human IgG1 monoclonal antibody that both bind to native and deacetylated glycoforms of PNAG mediated complement-dependent opsonic or bactericidal killing and protected mice against local and/or systemic infections by Streptococcus pyogenes, Streptococcus pneumoniae, Listeria monocytogenes, Neisseria meningitidis serogroup B, Candida albicans, and P. berghei ANKA, and against colonic pathology in a model of infectious colitis. PNAG is also a capsular polysaccharide for Neisseria gonorrhoeae and nontypable Hemophilus influenzae, and protects cells from environmental stress. Vaccination targeting PNAG could contribute to immunity against serious and diverse prokaryotic and eukaryotic pathogens, and the conserved production of PNAG suggests that it is a critical factor in microbial biology.
C1 [Cywes-Bentley, Colette; Skurnik, David; Zaidi, Tanweer; Roux, Damien; Lu, Xi; O'Malley, Jennifer; Kinzel, Kathryn; Zaidi, Tauqeer; Maira-Litran, Tomas; Pier, Gerald B.] Harvard Univ, Sch Med, Dept Med, Div Infect Dis,Brigham & Womens Hosp, Boston, MA 02115 USA.
[DeOliveira, Rosane B.; Golenbock, Douglas T.] Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA.
[Garrett, Wendy S.] Harvard Univ, Sch Publ Hlth, Dana Farber Canc Inst, Dept Immunol & Infect Dis, Boston, MA 02115 USA.
[Garrett, Wendy S.] Harvard Univ, Sch Publ Hlth, Dana Farber Canc Inst, Dept Genet, Boston, MA 02115 USA.
[Garrett, Wendy S.] Harvard Univ, Sch Publ Hlth, Dana Farber Canc Inst, Dept Complex Dis, Boston, MA 02115 USA.
[Rey, Astrid; Perrin, Christophe] Sanofi Res & Dev, Therapeut Strateg Unit, Infect Dis, F-31270 Toulouse, France.
[Fichorova, Raina N.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Lab Genital Tract Biol,Dept Obstet Gynecol & Repr, Boston, MA 02115 USA.
[Kayatani, Alexander K. K.] Walter Reed Army Inst Res, Mil Malaria Res Program, Vaccine Branch, Silver Spring, MD 20910 USA.
[Gening, Marina L.; Tsvetkov, Yury E.; Nifantiev, Nikolay E.] ND Zelinskii Inst Organ Chem, Lab Glycoconjugate Chem, Moscow 119991, Russia.
[Bakaletz, Lauren O.] Nationwide Childrens Hosp, Res Inst, Columbus, OH 43205 USA.
[Bakaletz, Lauren O.] Ohio State Univ, Coll Med, Columbus, OH 43205 USA.
[Pelton, Stephen I.] Boston Univ, Med Ctr, Dept Pediat Infect Dis, Boston, MA 02118 USA.
RP Pier, GB (reprint author), Harvard Univ, Sch Med, Dept Med, Div Infect Dis,Brigham & Womens Hosp, Boston, MA 02115 USA.
EM gpier@rics.bwh.harvard.edu
RI Roux, Damien/C-5618-2014; Fichorova, Raina/G-9969-2014; Roux,
Damien/L-3671-2014;
OI Roux, Damien/0000-0002-6103-6416; Roux, Damien/0000-0002-6103-6416;
Pier, Gerald/0000-0002-9112-2331; Pelton, Stephen/0000-0003-4862-5344
FU NIAID [AI46706, AI057159, U54 AI057159, 5R01AI079085-04, RO1AI079293]
FX We gratefully acknowledge the following individuals for supplying
microbial strains or tissue samples: Dr. Peter Rice (University of
Massachusetts Medical School); Dr. Lee Wetzler (Boston University
Medical School); Drs. Daniel Milner, Eric Rubin, and Marc Lipsitch
(Harvard School of Public Health), Drs. Richard Malley and Michael
Wessels (Children's Hospital, Harvard Medical School); Dr. Darren
Higgins (Harvard Medical School); Drs. Laurie Comstock, Maria
Chatzidaki-Livanis, Neeraj (Neil) Surana, and Lynn Bry (Brigham and
Women's Hospital, Harvard Medical School); Dr. Yung-Fu Chang (Cornell
College of Veterinary Medicine); Dr. Joanna Goldberg (University of
Virginia Medical School); Drs. Stanley Spinola and Margaret Bauer
(Indiana University Medical School); Dr. Darlene Miller (Bascom-Palmer
Eye Institute, University of Miami); Dr. Arturo Casadevall (Albert
Einstein College of Medicine); Dr. Janet Yother (University of Alabama,
Birmingham); Dr. Sandra Richter (University of Iowa); Dr. Janet Lindow
(University of Vermont); Dr. Alan Cross (University of Maryland School
of Medicine); Dr. Kwang Sik Kim (The Johns Hopkins University School of
Medicine); Dr. Rachel McLoughlin (University College Dublin); and Dr.
Johannes Huebner (Ludwig Maximilians University). We also gratefully
acknowledge the technical expertise and help of Ms. Maria Ericsson with
electron microscopy and Ms. Ariana Huebner with laboratory experiments.
This work was supported by NIAID Grants AI46706 and AI057159, a
component of Award U54 AI057159. The work with T. vaginalis was
supported by NIAID Grant 5R01AI079085-04 and the work with P. berghei
was supported by NIAID Grant RO1AI079293.
NR 58
TC 41
Z9 42
U1 0
U2 21
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD JUN 11
PY 2013
VL 110
IS 24
BP E2209
EP E2218
DI 10.1073/pnas.1303573110
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 171LM
UT WOS:000320930100011
PM 23716675
ER
PT J
AU Grande, M
Stomeo, T
Bianco, GV
Vincenti, MA
de Ceglia, D
Petruzzelli, V
Bruno, G
De Vittorio, M
Scalora, M
D'Orazio, A
AF Grande, M.
Stomeo, T.
Bianco, G. V.
Vincenti, M. A.
de Ceglia, D.
Petruzzelli, V.
Bruno, G.
De Vittorio, M.
Scalora, M.
D'Orazio, A.
TI Fabrication of doubly resonant plasmonic nanopatch arrays on graphene
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID RAMAN-SCATTERING; METAMATERIALS; ENHANCEMENT; SUBSTRATE; PLATFORM;
OPTICS
AB We report theoretical and experimental investigations of the optical response of two-dimensional periodic arrays of rectangular gold nanopatches grown on a monolayer graphene placed on a glass substrate. We discuss the numerical analysis and optical characterization by means of reflection spectra and show that rectangular nanopatches display a polarization-dependent response, at normal incidence, which leads to double plasmonic resonances due to the Wood anomaly. We detail the fabrication process highlighting how the resist primer and the adhesion layer can reduce and impede the graphene doping due to the environment and to the nanopatches, respectively, by means of Raman spectroscopy. (C) 2013 AIP Publishing LLC.
C1 [Grande, M.; Petruzzelli, V.; D'Orazio, A.] Politecn Bari, Dipartimento Ingn Elettr & Informaz, I-70125 Bari, Italy.
[Stomeo, T.; De Vittorio, M.] IIT, Ctr Biomol Nanotechnol, I-73010 Lecce, Italy.
[Bianco, G. V.; Bruno, G.] IMIP CNR, Inst Inorgan Methodol & Plasmas, I-70126 Bari, Italy.
[Vincenti, M. A.; de Ceglia, D.] CNR, AMRDEC, Charles M Bowden Res Lab, Redstone Arsenal, AL 35898 USA.
[De Vittorio, M.] Univ Salento, Ist Nansci, CNR, Dip Ingn Innovaz, I-73100 Lecce, Italy.
[Scalora, M.] USA, Charles M Bowden Res Lab, AMRDEC, RDECOM, Redstone Arsenal, AL 35898 USA.
RP Grande, M (reprint author), Politecn Bari, Dipartimento Ingn Elettr & Informaz, Via Re David 200, I-70125 Bari, Italy.
RI Petruzzelli, Vincenzo/E-5576-2015; Petruzzelli, Vincenzo/H-5188-2012; De
Vittorio, Massimo/I-5250-2012;
OI BRUNO, GIOVANNI/0000-0003-3116-1176; Petruzzelli,
Vincenzo/0000-0001-6921-9981; Petruzzelli, Vincenzo/0000-0001-6921-9981;
De Vittorio, Massimo/0000-0003-1601-6392; BIANCO, GIUSEPPE
VALERIO/0000-0002-0986-1531
FU U.S. Army International Technology Center Atlantic [W911NF-12-1-0292]
FX M. Grande thanks the U.S. Army International Technology Center Atlantic
for financial support (W911NF-12-1-0292). This research was performed
while the authors M. A. Vincenti and D. de Ceglia held a National
Research Council Research Associateship awards at the U.S. Army Aviation
and Missile Research Development and Engineering Center.
NR 27
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U1 2
U2 33
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0003-6951
EI 1077-3118
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD JUN 10
PY 2013
VL 102
IS 23
AR 231111
DI 10.1063/1.4810785
PG 5
WC Physics, Applied
SC Physics
GA 167HQ
UT WOS:000320622600011
ER
PT J
AU Matyas, GR
Mayorov, AV
Rice, KC
Jacobson, AE
Cheng, KJ
Iyer, MR
Li, FY
Beck, Z
Janda, KD
Alving, CR
AF Matyas, Gary R.
Mayorov, Alexander V.
Rice, Kenner C.
Jacobson, Arthur E.
Cheng, Kejun
Iyer, Malliga R.
Li, Fuying
Beck, Zoltan
Janda, Kim D.
Alving, Carl R.
TI Liposomes containing monophosphoryl lipid A: A potent adjuvant system
for inducing antibodies to heroin hapten analogs
SO VACCINE
LA English
DT Article
DE Liposomes containing monophosphoryl lipid A; Adjuvant system; Opiate
vaccine; Antibodies to heroin haptens
ID MORPHINE/HEROIN VACCINE; ALUMINUM-HYDROXIDE; DRUG-ABUSE; PEPTIDES;
SPECIFICITIES; CHOLESTEROL; ANTIGENS; CODEINE; RELAPSE; RATS
AB In order to create an effective immunization approach for a potential vaccine to heroin, liposomes containing monophosphoryl lipid A [L(MPLA)] were tested as an adjuvant system to induce antibodies to heroin hapten analogs. Four synthetic haptens and two immunization strategies were employed. In the first strategy, a hydrophobic 23 amino acid immunogenic peptide derived from the membrane proximal external region of gp41 from HIV-1 envelope protein was embedded as a carrier in the outer surface of L(MPLA), to which was conjugated a 15 amino acid universal T cell epitope and a terminal heroin hapten analog. In the second strategy, tetanus toxoid (TT) carrier protein was decorated with haptens by conjugation, and the hapten-conjugated protein was mixed with L(MPLA). After immunization of mice, each of the immunization strategies was effective for induction of IgG anti-hapten antibodies. The first immunization strategy induced a mean end-point IgG titer against one of two haptens tested of approximately 12,800; however, no detectable antibodies were induced against the liposome-associated HIV-1 carrier peptide. In the second immunization strategy, depending on the hapten used for decorating the TT, end-point IgG titers ranged from 100,000 to 6,500,000. In this strategy, in which hapten was conjugated to the TT, end-point IgG titers of 400,000 to the TT carrier were observed with each conjugate. However, upon mixing unconjugated TT with L(MPLA), anti-TT titers of 6,500,000 were observed. We conclude that L(MPLA) serves as a potent adjuvant for inducing antibodies to candidate heroin haptens. However, antibodies to the carrier peptide or protein were partly or completed inhibited by the presence of conjugated hapten. Published by Elsevier Ltd.
C1 [Matyas, Gary R.; Mayorov, Alexander V.; Beck, Zoltan; Alving, Carl R.] Walter Reed Army Inst Res, Lab Adjuvant & Antigen Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
[Mayorov, Alexander V.; Beck, Zoltan] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD 20817 USA.
[Rice, Kenner C.; Jacobson, Arthur E.; Cheng, Kejun; Li, Fuying] NIDA, Chem Biol Res Branch, NIH, Rockville, MD 20852 USA.
[Iyer, Malliga R.] NIAAA, NIH, Rockville, MD 20852 USA.
[Janda, Kim D.] Scripps Res Inst, Dept Chem, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA.
[Janda, Kim D.] Scripps Res Inst, Dept Immunol, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA.
[Janda, Kim D.] Scripps Res Inst, Worm Inst Res & Med, La Jolla, CA 92037 USA.
RP Alving, CR (reprint author), Walter Reed Army Inst Res, Lab Adjuvant & Antigen Res, US Mil HIV Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM calving@hivresearch.org
OI Matyas, Gary/0000-0002-2074-2373
FU Henry M. Jackson Foundation for the Advancement of Military Medicine
[W81XWH-07-2-067]; U.S. Army Medical Research and Materiel Command
(MRMC) [W81XWH-07-2-067]; MRMC [Y1-DA0121-01]; National Institute on
Drug Abuse [Y1-DA0121-01]; NIH Intramural Research Program of the
National Institute on Drug Abuse; NIH Intramural Research Program of the
National Institute of Alcohol Abuse and Alcoholism, NIH, DHHS; NIH [DA
026625]
FX This work was supported through a Cooperative Agreement Award (no.
W81XWH-07-2-067) between the Henry M. Jackson Foundation for the
Advancement of Military Medicine and the U.S. Army Medical Research and
Materiel Command (MRMC). The work was partially supported by an
interagency agreement (Y1-DA0121-01 to CRA) between MRMC and the
National Institute on Drug Abuse. The work of KC, FL, MRI, AEJ, and KCR
was supported by the NIH Intramural Research Programs of the National
Institute on Drug Abuse and the National Institute of Alcohol Abuse and
Alcoholism, NIH, DHHS. KJ was supported in part by NIH grant no. DA
026625. Research was conducted in compliance with the Animal Welfare Act
and other federal statutes and regulations relating to animals and
experiments involving animals and adhered to principles stated in the
Guide for the Care and Use of Laboratory Animals, NRC Publication, 1996
edition.
NR 40
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U1 0
U2 31
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
J9 VACCINE
JI Vaccine
PD JUN 10
PY 2013
VL 31
IS 26
BP 2804
EP 2810
DI 10.1016/j.vaccine.2013.04.027
PG 7
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 168ZD
UT WOS:000320745600004
PM 23624097
ER
PT J
AU Brozena, A
AF Brozena, Ann
TI Vapor pressure of 1-octanol below 5 kPa using DSC
SO THERMOCHIMICA ACTA
LA English
DT Article
DE Vapor pressure; DSC; Differential scanning calorimetry; Thermal
analysis; ASTM; Pinhole method
AB American Society for Testing and Materials (ASTM) Method E 1782-08, Standard Test Method for Determining Vapor Pressure by Thermal Analysis recommends use of hermetic-type sealable sample pans with a single 50-75 mu m pinhole in the lid for pressures between 5 kPa and 2 MPa. At pressures below 5 kPa using the recommended pinhole range, boiling endotherms become increasingly broad. Earlier studies demonstrated qualitative improvement in endotherm sharpness with use of larger pinholes (up to 350 mu m) at pressures below 5 kPa. In the current work, the vapor pressure of 1-octanol was determined in accordance with ASTM E 1782-08 using pinholes ranging from 75 to 350 mu m from atmospheric pressure down to 0.197 kPa. These results clearly indicate that vapor pressure data in good agreement with the literature can be produced for 1-octanol at pressures as low as 0.2 kPa if pinhole sizes up to 350 mu m are used; the results are comparable to those generated using the current ASTM-recommended pressure and pinhole parameters. Published by Elsevier B.V.
C1 USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
RP Brozena, A (reprint author), USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
EM ann.brozena.civ@mail.mil
NR 12
TC 9
Z9 9
U1 3
U2 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0040-6031
J9 THERMOCHIM ACTA
JI Thermochim. Acta
PD JUN 10
PY 2013
VL 561
BP 72
EP 76
DI 10.1016/j.tca.2013.03.018
PG 5
WC Thermodynamics; Chemistry, Analytical; Chemistry, Physical
SC Thermodynamics; Chemistry
GA 153YN
UT WOS:000319638800010
ER
PT J
AU Umezu, I
Warrender, JM
Charnvanichborikarn, S
Kohno, A
Williams, JS
Tabbal, M
Papazoglou, DG
Zhang, XC
Aziz, MJ
AF Umezu, Ikurou
Warrender, Jeffrey M.
Charnvanichborikarn, Supakit
Kohno, Atsushi
Williams, James S.
Tabbal, Malek
Papazoglou, Dimitris G.
Zhang, Xi-Cheng
Aziz, Michael J.
TI Emergence of very broad infrared absorption band by hyperdoping of
silicon with chalcogens
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
ID MICROSTRUCTURED SILICON; DOPED SILICON; SULFUR; FEMTOSECOND
AB We report the near through mid-infrared (MIR) optical absorption spectra, over the range 0.05-1.3 eV, of monocrystalline silicon layers hyperdoped with chalcogen atoms synthesized by ion implantation followed by pulsed laser melting. A broad mid-infrared optical absorption band emerges, peaking near 0.5 eV for sulfur and selenium and 0.3 eV for tellurium hyperdoped samples. Its strength and width increase with impurity concentration. Its strength decreases markedly with subsequent thermal annealing. The emergence of a broad MIR absorption band is consistent with the formation of an impurity band from isolated deep donor levels as the concentration of chalcogen atoms in metastable local configurations increases. (C) 2013 AIP Publishing LLC.
C1 [Umezu, Ikurou] Konan Univ, Dept Phys, Kobe, Hyogo 6588501, Japan.
[Warrender, Jeffrey M.] US Army, ARDEC Benet Labs, Watervliet, NY 12189 USA.
[Charnvanichborikarn, Supakit; Williams, James S.] Australian Natl Univ, Res Sch Phys & Engn, Canberra, ACT 0200, Australia.
[Kohno, Atsushi] Fukuoka Univ, Dept Appl Phys, Fukuoka 8140180, Japan.
[Tabbal, Malek] Amer Univ Beirut, Dept Phys, Beirut 11072020, Lebanon.
[Papazoglou, Dimitris G.] Fdn Res & Technol Hellas, Inst Elect Struct & Laser, Iraklion 71110, Greece.
[Papazoglou, Dimitris G.] Univ Crete, Mat Sci & Technol Dept, Iraklion 71003, Greece.
[Zhang, Xi-Cheng] Rensselaer Polytech Inst, Dept Phys Appl Phys & Astron, Troy, NY 12180 USA.
[Aziz, Michael J.] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA.
RP Umezu, I (reprint author), Konan Univ, Dept Phys, Kobe, Hyogo 6588501, Japan.
RI Papazoglou, Dimitris/D-9146-2013; Zhang, Xi-Cheng/G-1306-2016
OI Papazoglou, Dimitris/0000-0003-4537-5108; Zhang,
Xi-Cheng/0000-0003-3721-1357
FU Fulbright Program; U.S. Army ARDEC [W15QKN-07-P-0092]; Japan Society for
the Promotion of Science; Australian Research Council
FX The authors gratefully acknowledge technical assistance from Yunqing
Chen and helpful conversations with D. Recht, M. Winkler, J. Carey, P.
Persans, and E. Mazur, and are grateful to D. Recht for assistance with
manuscript preparation. M. T. acknowledges the financial support of the
Fulbright Program. This research was supported in part by the U.S. Army
ARDEC under Contract No. W15QKN-07-P-0092, and a Grant-in-Aid for
Scientific Research from the Japan Society for the Promotion of Science.
The Australian Research Council is also acknowledged for partial
financial support.
NR 28
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Z9 19
U1 1
U2 37
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0021-8979
J9 J APPL PHYS
JI J. Appl. Phys.
PD JUN 7
PY 2013
VL 113
IS 21
AR 213501
DI 10.1063/1.4804935
PG 7
WC Physics, Applied
SC Physics
GA 167ZQ
UT WOS:000320674500017
ER
PT J
AU Vignes, RM
Becker, R
Stolken, J
Kumar, M
AF Vignes, Ryan M.
Becker, Richard
Stoelken, James
Kumar, Mukul
TI An assessment of diamond anvil cell measurements on material strength
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
ID HIGH-PRESSURE CELLS; HYDROSTATIC-PRESSURE; ULTRAHIGH PRESSURES;
FLOW-STRESS; FRICTION; COMPRESSION; COEFFICIENT; TECHNOLOGY; ASPERITY;
METAL
AB Diamond anvil cell (DAC) experiments have been used in various studies to determine plastic flow strength in ductile metals at high pressure. To gain insight into the experiments and assess how accurately the material's strength at pressure can be determined, finite element simulations of DAC experiments are performed. In the analyses, constitutive responses are assumed for the diamonds and the vanadium test specimen; within the constitutive models, the pressure dependence of the strength is prescribed. The quantities typically measured during experiments are extracted from the simulations and analyzed in an identical manner as the experimental data would be to obtain the pressure dependent flow strength. This computed pressure dependent strength is then compared with the prescribed input, allowing the accuracy and sensitivities of the experimental technique to be evaluated. Recommendations are made to improve the accuracy of strength determinations. (C) 2013 AIP Publishing LLC.
C1 [Vignes, Ryan M.; Stoelken, James; Kumar, Mukul] Lawrence Livermore Natl Lab, Livermore, CA 94551 USA.
[Becker, Richard] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Vignes, RM (reprint author), Lawrence Livermore Natl Lab, POB 808, Livermore, CA 94551 USA.
EM mukul@llnl.gov
RI Becker, Richard/I-1196-2013
FU U.S. Department of Energy by Lawrence Livermore National Laboratory
[DE-AC52-07NA27344]
FX This work performed under the auspices of the U.S. Department of Energy
by Lawrence Livermore National Laboratory under Contract
DE-AC52-07NA27344.
NR 31
TC 2
Z9 2
U1 2
U2 33
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0021-8979
J9 J APPL PHYS
JI J. Appl. Phys.
PD JUN 7
PY 2013
VL 113
IS 21
AR 213503
DI 10.1063/1.4807786
PG 10
WC Physics, Applied
SC Physics
GA 167ZQ
UT WOS:000320674500019
ER
PT J
AU Yang, SC
Sanghadasa, M
Priya, S
AF Yang, Su Chul
Sanghadasa, Mohan
Priya, Shashank
TI Highly ordered Pb(Zr0.52Ti0.48)O-3 piezoelectric nanorod arrays
SO NANOTECHNOLOGY
LA English
DT Article
ID NANOWIRE ARRAYS; NANOTUBES; NANOSTRUCTURES; NANOFIBERS
AB One-dimensional (1D) piezoelectric nanostructures have attracted significant attention for a broad range of applications including optoelectronics, thermoelectrics, electrochemical and electromechanical converters. We demonstrate the synthesis of 1D nanostructures based upon Pb(Zr0.52Ti0.48)O-3 (PZT) on conductive substrates via sol-gel template synthesis. The vertically aligned PZT nanostructures with heights around one micron were synthesized by vacuum infiltration of sol-gel precursors into highly ordered cylindrical pores of anodized aluminum oxide templates. The 1D nanostructures were developed on large scale platinized silicon wafers and exhibited dense rod-like structure with a uniform diameter of 90 nm and an aspect ratio of 10. Scanning probe microscopy conducted on individual nanorods demonstrated good electromechanical properties with a high piezoelectric magnitude of 41 pm V-1. We believe that this study opens the possibility of developing high performance nanoscale piezoelectric sensors and transducers.
C1 [Yang, Su Chul; Priya, Shashank] Virginia Tech, Bioinspired Mat & Devices Lab BMDL, Ctr Energy Harvesting Mat & Syst CEHMS, Blacksburg, VA 24061 USA.
[Sanghadasa, Mohan] USA, Weap Sci Directorate, Aviat & Missile Res Dev & Engn Ctr, RDECOM, Redstone Arsenal, AL 35898 USA.
RP Yang, SC (reprint author), Virginia Tech, Bioinspired Mat & Devices Lab BMDL, Ctr Energy Harvesting Mat & Syst CEHMS, Blacksburg, VA 24061 USA.
EM spriya@vt.edu
FU US Army Aviation and Missile Research, Development, and Engineering
Center through CEHMS
FX We gratefully acknowledge the financial support from US Army Aviation
and Missile Research, Development, and Engineering Center through CEHMS
seed program. The authors would sincerely like to thank Dr Ashok Kumar
for his valuable contributions in revising the manuscript and helping
with the submission.
NR 28
TC 1
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U1 4
U2 52
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0957-4484
J9 NANOTECHNOLOGY
JI Nanotechnology
PD JUN 7
PY 2013
VL 24
IS 22
AR 225303
DI 10.1088/0957-4484/24/22/225303
PG 6
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Physics, Applied
SC Science & Technology - Other Topics; Materials Science; Physics
GA 149NH
UT WOS:000319326600008
PM 23637024
ER
PT J
AU Sedegah, M
Kim, Y
Ganeshan, H
Huang, J
Belmonte, M
Abot, E
Banania, JG
Farooq, F
McGrath, S
Peters, B
Sette, A
Soisson, L
Diggs, C
Doolan, DL
Tamminga, C
Villasante, E
Hollingdale, MR
Richie, TL
AF Sedegah, Martha
Kim, Yohan
Ganeshan, Harini
Huang, Jun
Belmonte, Maria
Abot, Esteban
Banania, Jo Glenna
Farooq, Fouzia
McGrath, Shannon
Peters, Bjoern
Sette, Alessandro
Soisson, Lorraine
Diggs, Carter
Doolan, Denise L.
Tamminga, Cindy
Villasante, Eileen
Hollingdale, Michael R.
Richie, Thomas L.
TI Identification of minimal human MHC-restricted CD8+ T-cell epitopes
within the Plasmodium falciparum circumsporozoite protein (CSP)
SO MALARIA JOURNAL
LA English
DT Article
DE Malaria; Vaccine; Circumsporozoite protein; ELISpot; Flow cytometry;
NetMHC; Epitope mapping; Class I restriction; Localization
ID I ALLELE PROMISCUITY; MALARIA DNA VACCINE; PEPTIDE-BINDING; HLA-A;
SUPERTYPES; MOLECULES; RESPONSES; ANTIGENS; IMMUNOGENICITY; POLYMORPHISM
AB Background: Plasmodium falciparum circumsporozoite protein (CSP) is a leading malaria vaccine candidate antigen, known to elicit protective antibody responses in humans (RTS, S vaccine). Recently, a DNA prime/adenovirus (Ad) vector boost vaccine encoding CSP and a second P. falciparum antigen, apical membrane antigen-1, also elicited sterile protection, but in this case associated with interferon gamma ELISpot and CD8+ T cell but not antibody responses. The finding that CSP delivered by an appropriate vaccine platform likely elicits protective cell-mediated immunity provided a rationale for identifying class I-restricted epitopes within this leading vaccine candidate antigen.
Methods: Limited samples of peripheral blood mononuclear cells from clinical trials of the Ad vaccine were used to identify CD8+ T cell epitopes within pools of overlapping 15mer peptides spanning portions of CSP that stimulated recall responses. Computerized algorithms (NetMHC) predicted 17 minimal class I-restricted 9-10mer epitopes within fifteen 15mers positive in ELISpot assay using PBMC from 10 HLA-matched study subjects. Four additional epitopes were subsequently predicted using NetMHC, matched to other study subjects without initial 15mer ELISpot screening. Nine of the putative epitopes were synthesized and tested by ELISpot assay, and six of these nine were further tested for CD8+ T cell responses by ELISpot CD4+ and CD8+ T cell-depletion and flow cytometry assays for evidence of CD8+ T cell dependence.
Results: Each of the nine putative epitopes, all sequence-conserved, recalled responses from HLA-matched CSP-immunized research subjects. Four shorter sequences contained within these sequences were identified using NetMHC predictions and may have contributed to recall responses. Five (9-10mer) epitopes were confirmed to be targets of CD8+ T cell responses using ELISpot depletion and ICS assays. Two 9mers among these nine epitopes were each restricted by two HLA supertypes (A01/B07; A01A24/A24) and one 9mer was restricted by three HLA supertypes (A01A24/A24/B27) indicating that some CSP class I-restricted epitopes, like DR epitopes, may be HLA-promiscuous.
Conclusions: This study identified nine and confirmed five novel class I epitopes restricted by six HLA supertypes, suggesting that an adenovirus-vectored CSP vaccine would be immunogenic and potentially protective in genetically diverse populations.
C1 [Sedegah, Martha; Ganeshan, Harini; Huang, Jun; Belmonte, Maria; Abot, Esteban; Banania, Jo Glenna; Farooq, Fouzia; McGrath, Shannon; Tamminga, Cindy; Villasante, Eileen; Hollingdale, Michael R.; Richie, Thomas L.] USN, Med Res Ctr, Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD USA.
[Kim, Yohan; Peters, Bjoern; Sette, Alessandro] La Jolla Inst Allergy & Immunol, La Jolla, CA USA.
[Doolan, Denise L.] Queensland Inst Med Res, Brisbane, Qld 4006, Australia.
[Soisson, Lorraine; Diggs, Carter] USAID, Washington, DC USA.
RP Sedegah, M (reprint author), USN, Med Res Ctr, Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD USA.
EM martha.sedegah@med.navy.mil
RI Doolan, Denise/F-1969-2015;
OI Richie, Thomas/0000-0002-2946-5456
FU Naval Medical Research Center [6000.RAD1.F.A0309]; USAID; Military
Infectious Diseases Research Program; Congressionally Directed Medical
Research Program; Pfizer Australia
FX CT, EV, and TLR were active duty military personnel at the time they
contributed to this work; MS is a US Government employee. The work of
these individuals was prepared as part of official government duties.
Title 17 USC 105 provides that 'Copyright protection under this title is
not available for any work of the United States Government.' Title 17
USC 101 defines a US Government work as a work prepared by a military
service member or employee of the US Government as part of that person's
official duties. The work of authors affiliated with the Naval Medical
Research Center was supported by work unit number 6000.RAD1.F.A0309.
Major funding for this work was provided by USAID, the Military
Infectious Diseases Research Program, and the Congressionally Directed
Medical Research Program. DLD was supported by a Pfizer Australia Senior
Research Fellowship. The study protocol for the clinical trial presented
in this manuscript was approved by the National Naval Medical Center,
Naval Medical Research Center and Walter Reed Army Institute of Research
Institutional Review Boards, in compliance with all applicable federal
regulations governing protection of human subjects. All study subjects
gave written informed consent. The views expressed in this article are
those of the authors and do not necessarily reflect the official policy
or position of the Department of the Navy, the Department of the Army,
the Department of Defense, or the US Government. We gratefully
acknowledge the assistance of Jennifer Ng in the HLA typing of the
research subjects.
NR 62
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U1 0
U2 11
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD JUN 5
PY 2013
VL 12
AR 185
DI 10.1186/1475-2875-12-185
PG 17
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 163WH
UT WOS:000320367900001
PM 23738590
ER
PT J
AU Rigler, M
Zgonik, M
Hoffmann, MP
Kirste, R
Bobea, M
Collazo, R
Sitar, Z
Mita, S
Gerhold, M
AF Rigler, Martin
Zgonik, Marko
Hoffmann, Marc P.
Kirste, Ronny
Bobea, Milena
Collazo, Ramon
Sitar, Zlatko
Mita, Seiji
Gerhold, Michael
TI Refractive index of III-metal-polar and N-polar AlGaN waveguides grown
by metal organic chemical vapor deposition
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID LIGHT-EMITTING-DIODES; PRISM COUPLER; GAN; FILMS; ALXGA1-XN;
TEMPERATURE; ALN; SUSCEPTIBILITIES; WAVELENGTH; GENERATION
AB Optical waveguides of III-metal-polar and N-polar AlGaN are grown on sapphire substrates in order to test their use in integrated optics. The dispersion of the ordinary and extraordinary indices of refraction for films with aluminum mole fraction between 0.0 and 0.30 at four discrete wavelengths has been determined by the prism coupling method. The wavelength dependence of the refractive indices is described well by the first-order Sellmeier dispersion formula. The measurements show a small difference in the refractive indices between the two polarities, which is more pronounced at longer wavelengths. (C) 2013 American Institute of Physics.
C1 [Rigler, Martin; Zgonik, Marko] Univ Ljubljana, Fac Math & Phys, Ljubljana 1000, Slovenia.
[Rigler, Martin; Zgonik, Marko] Jozef Stefan Inst, Ljubljana 1000, Slovenia.
[Hoffmann, Marc P.; Kirste, Ronny; Bobea, Milena; Collazo, Ramon; Sitar, Zlatko] N Carolina State Univ, Mat Sci & Engn Dept, Raleigh, NC 27606 USA.
[Mita, Seiji] HexaTech Inc, Morrisville, NC 27560 USA.
[Gerhold, Michael] Army Res Off, Engn Sci Directorate, Res Triangle Pk, NC 27703 USA.
RP Rigler, M (reprint author), Univ Ljubljana, Fac Math & Phys, Jadranska 19, Ljubljana 1000, Slovenia.
EM martin.rigler@fmf.uni-lj.si
RI Zgonik, Marko/K-9092-2015
OI Zgonik, Marko/0000-0002-2307-8797
FU Army Research Laboratory [W911NF-04-D-0003]; William Clark program
monitor; NSF [DMR-1108071]
FX The NCSU group acknowledges a partial financial support by the Army
Research Laboratory, Contract No.: W911NF-04-D-0003, William Clark
program monitor and NSF under Contract DMR-1108071.
NR 45
TC 9
Z9 9
U1 3
U2 32
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0003-6951
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD JUN 3
PY 2013
VL 102
IS 22
AR 221106
DI 10.1063/1.4800554
PG 5
WC Physics, Applied
SC Physics
GA 167HH
UT WOS:000320621600006
ER
PT J
AU Terrill, WA
AF Terrill, W. Andrew
TI Nasser's Gamble: How Intervention in Yemen Caused the Six-Day War and
the Decline of Egyptian Power
SO MIDDLE EAST JOURNAL
LA English
DT Book Review
C1 [Terrill, W. Andrew] US Army War Coll, Strateg Studies Inst, Carlisle, PA 17013 USA.
RP Terrill, WA (reprint author), US Army War Coll, Strateg Studies Inst, Carlisle, PA 17013 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU MIDDLE EAST INST
PI WASHINGTON
PA 1761 N ST NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 USA
SN 0026-3141
J9 MIDDLE EAST J
JI Middle East J.
PD SUM
PY 2013
VL 67
IS 3
BP 478
EP 480
PG 3
WC Area Studies
SC Area Studies
GA AG2UU
UT WOS:000335273400013
ER
PT J
AU Welton, MD
AF Welton, Mark D.
TI The Impossible State: Islam, Politics, and Modernity's Moral Predicament
SO MIDDLE EAST JOURNAL
LA English
DT Book Review
C1 [Welton, Mark D.] US Mil Acad, West Point, NY 10996 USA.
RP Welton, MD (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU MIDDLE EAST INST
PI WASHINGTON
PA 1761 N ST NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 USA
SN 0026-3141
J9 MIDDLE EAST J
JI Middle East J.
PD SUM
PY 2013
VL 67
IS 3
BP 492
EP 493
PG 2
WC Area Studies
SC Area Studies
GA AG2UU
UT WOS:000335273400023
ER
PT J
AU Blair, JA
Owens, JG
Saucedo, J
Hsu, JR
AF Blair, James A.
Owens, Johnny G.
Saucedo, Joey
Hsu, Joseph R.
CA Skeletal Trauma Res
TI Functional Rehabilitation With a Foot Plate Modification for Circular
External Fixation
SO FOOT & ANKLE INTERNATIONAL
LA English
DT Article
DE Taylor spatial frame; Ilizarov; foot plate; limb salvage; Return To Run
ID OPERATION ENDURING FREEDOM; LOWER-EXTREMITY TRAUMA; TIBIAL FRACTURES;
ILIZAROV METHOD; IRAQI FREEDOM; LIMB SALVAGE; DEFECTS; BONE; WOUNDS;
REPAIR
AB Background: Customized foot plates attached to the foot ring of an ankle-spanning circular external fixator present a unique opportunity for patients undergoing complex lower-extremity limb salvage to participate in highly advanced weight-bearing physical therapy. The purpose of this study was to identify the rehabilitation capabilities afforded by this external fixator modification.
Methods: Surgical logs and radiographs were reviewed to identify all lower-extremity limb salvage patients from February 2008 to December 2010 treated with an ankle-spanning circular external fixator and a customized foot plate treated by the same orthopedic surgeon and enrolled in our institution's Return To Run clinical pathway. Medical records were reviewed to identify a series of exercises that each patient was able to perform.
Results: Eleven patients were identified. All patients were treated by the same physical therapist. All 11 patients were able to bear full weight on their foot plates and perform regular and split squats. Six of 11 patients were able to ambulate unassisted, and 5 patients required a cane. All 11 patients could navigate stairs and use an elliptical and stair-stepping machine. Six of 11 patients could perform single-leg hack squats. Eight of 11 patients were able to perform double-leg shuttle jumps, although only 5 of 11 patients could perform single-leg shuttle jumps. Five of 11 patients were able to perform a single-leg balance. Only 1 patient was able to run on the foot plate.
Conclusions: Patients undergoing lower-extremity limb salvage with an ankle-spanning circular external fixator and a customized foot plate were able to participate in highly advanced weight-bearing physical therapy exercises during the osseous and soft-tissue healing process.
C1 [Blair, James A.; Saucedo, Joey] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA.
[Owens, Johnny G.] Brooke Army Med Ctr, Ctr Intrepid, Ft Sam Houston, TX 78234 USA.
[Hsu, Joseph R.] Carolinas Med Ctr, Charlotte, NC 28203 USA.
[Skeletal Trauma Res] US Army Inst Surg Res, Ft Sam Houston, TX USA.
RP Blair, JA (reprint author), Brooke Army Med Ctr, Dept Orthopaed & Rehabil, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM james.blair@amedd.army.mil
FU United States Army Institute of Surgical Research; Combat Casualty Care
Research Program
FX The authors declared receipt of the following financial support for the
research, authorship, and/or publication of this article: This study was
funded by the United States Army Institute of Surgical Research and the
Combat Casualty Care Research Program.
NR 19
TC 2
Z9 2
U1 1
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1071-1007
EI 1944-7876
J9 FOOT ANKLE INT
JI Foot Ankle Int.
PD JUN
PY 2013
VL 34
IS 6
BP 890
EP 897
DI 10.1177/1071100713483975
PG 8
WC Orthopedics
SC Orthopedics
GA 298FI
UT WOS:000330309100018
PM 23564426
ER
PT J
AU Secord, AA
Barnett, JC
Ledermann, JA
Peterson, BL
Myers, ER
Havrilesky, LJ
AF Secord, Angeles Alvarez
Barnett, Jason Cory
Ledermann, Jonathan A.
Peterson, Bercedis L.
Myers, Evan R.
Havrilesky, Laura J.
TI Cost-Effectiveness of BRCA1 and BRCA2 Mutation Testing to Target PARP
Inhibitor Use in Platinum-Sensitive Recurrent Ovarian Cancer
SO INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
LA English
DT Article
DE Biomarkers; PARP inhibitors; Ovarian cancer; Cost-effectiveness
ID BREAST-CANCER; AMERICAN-SOCIETY; POLY(ADP-RIBOSE) POLYMERASE;
GENE-MUTATIONS; CARCINOMA; THERAPY; RECOMMENDATIONS; TRASTUZUMAB;
BEVACIZUMAB; POPULATION
AB Objectives: (1) To determine whether use of a PARP inhibitor or (2) BRCA1/2 mutation testing followed by a PARP inhibitor for test positives is potentially cost-effective for maintenance treatment of platinum-sensitive recurrent high-grade serous ovarian cancer.
Methods: A modified Markov decision analysis compared 3 strategies: (1) observe; (2) olaparib to progression; (3) BRCA1/2 mutation testing; treat mutation carriers with olaparib to progression. Progression-free survival and rates of adverse events were derived from a phase 2 randomized trial. Key assumptions are as follows: (1) 14% of patients harbor a BRCA1/2 mutation; (2) progression-free survival of individuals treated with olaparib is improved for BCRA1/2 carriers compared with noncarriers (estimated hazard ratio, approximately 0.4). Costs derived from national data were assigned to treatments, adverse events, and BRCA1/2 test. Monte Carlo probabilistic sensitivity analysis was performed.
Results: Global olaparib was the most effective strategy, followed by BRCA1/2 testing and no olaparib. BRCA1/2 testing had an incremental cost-effectiveness ratio (ICER) of $193,442 per progression-free year of life saved (PF-YLS) compared to no olaparib, whereas global olaparib had an ICER of $234,128 per PF-YLS compared to BRCA1/2 testing. At a 52% lower-than-baseline olaparib cost estimate of $3000 per month, BRCA1/2 testing became potentially cost-effective compared with observation, with an ICER of $100,000 per PF-YLS. When strategy (1) was removed from the analysis, BRCA1/2 testing was the preferred strategy.
Conclusions: The use of maintenance olaparib in women with high-grade serous ovarian cancer is not cost-effective regardless of whether BRCA1/2 testing is used to direct treatment. However, BRCA1/2 testing is a preferred strategy compared to global maintenance olaparib alone.
C1 [Secord, Angeles Alvarez; Havrilesky, Laura J.] Duke Univ, Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol,Duke Canc Inst, Durham, NC 27710 USA.
[Barnett, Jason Cory] Brooke Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Ft Sam Houston, TX 78234 USA.
[Ledermann, Jonathan A.] UCL Canc Inst, London, England.
[Ledermann, Jonathan A.] Biomed Res Ctr, London, England.
[Peterson, Bercedis L.] Duke Univ, Med Ctr, Dept Biostat & Bioinformat, Durham, NC 27710 USA.
[Myers, Evan R.] Duke Univ, Med Ctr, Dept Obstet & Gynecol, Div Clin & Epidemiol Res, Durham, NC 27710 USA.
RP Secord, AA (reprint author), Duke Univ, Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, DUMC 3079, Durham, NC 27710 USA.
EM secor002@mc.duke.edu
NR 28
TC 7
Z9 8
U1 2
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1048-891X
EI 1525-1438
J9 INT J GYNECOL CANCER
JI Int. J. Gynecol. Cancer
PD JUN
PY 2013
VL 23
IS 5
BP 846
EP 852
DI 10.1097/IGC.0b013e31829527bd
PG 7
WC Oncology; Obstetrics & Gynecology
SC Oncology; Obstetrics & Gynecology
GA 299CU
UT WOS:000330373500013
PM 23666017
ER
PT J
AU Atkins, AF
AF Atkins, Alison F.
TI FROM A DREAM TO A REALITY CHECK: PROTECTING THE RIGHTS OF TOMORROW'S
CONDITIONAL LEGAL RESIDENT ENLISTEES
SO MILITARY LAW REVIEW
LA English
DT Article
C1 [Atkins, Alison F.] US Army, Adelphi, MD USA.
[Atkins, Alison F.] 1st Armored Div, Wiesbaden, Germany.
[Atkins, Alison F.] Patton Legal Ctr, Heidelberg, Germany.
RP Atkins, AF (reprint author), 10th Mt Div Light Infantry, Criminal Law Div, Ft Drum, NY 13602 USA.
NR 66
TC 0
Z9 0
U1 1
U2 1
PU JUDGE ADVOCATE GENERALS SCHOOL
PI CHARLOTTESVILLE
PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA
SN 0026-4040
J9 MIL LAW REV
JI Milit. Law Rev.
PD SUM
PY 2013
VL 216
BP 1
EP 76
PG 76
WC Law
SC Government & Law
GA 299UB
UT WOS:000330420100001
ER
PT J
AU Sykes, MSC
AF Sykes, Major Sarah C.
TI "DEFENSE COUNSEL, PLEASE RISE": A COMPARATIVE ANALYSIS OF TRIAL IN
ABSENTIA
SO MILITARY LAW REVIEW
LA English
DT Article
C1 [Sykes, Major Sarah C.] US Army, Charlottesville, VA 22901 USA.
RP Sykes, MSC (reprint author), US Army, Judge Advocate Gen Sch, Charlottesville, VA 22901 USA.
NR 39
TC 0
Z9 0
U1 3
U2 3
PU JUDGE ADVOCATE GENERALS SCHOOL
PI CHARLOTTESVILLE
PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA
SN 0026-4040
J9 MIL LAW REV
JI Milit. Law Rev.
PD SUM
PY 2013
VL 216
BP 170
EP 211
PG 42
WC Law
SC Government & Law
GA 299UB
UT WOS:000330420100004
ER
PT J
AU Finan, PH
Quartana, PJ
Smith, MT
AF Finan, Patrick H.
Quartana, Phillip J.
Smith, Michael T.
TI Positive and Negative Affect Dimensions in Chronic Knee Osteoarthritis:
Effects on Clinical and Laboratory Pain
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE positive affect; negative affect; chronic pain; daily diary;
quantitative sensory testing; temporal summation
ID FIBER-EVOKED PAIN; SLOW TEMPORAL SUMMATION; FIBROMYALGIA PATIENTS;
WIND-UP; POLYMORPHISM 5-HTTLPR; SLEEP DISTURBANCE; HEALTH COMPLAINTS;
SHOULDER PAIN; OLDER-ADULTS; ARTHRITIS
AB Objective: This study investigated whether daily and laboratory assessed pain differs as a function of the temporal stability and valence of affect in individuals with chronic knee osteoarthritis (KOA). Methods: One hundred fifty-one men and women with KOA completed 14 days of electronic diaries assessing positive affect (PA), negative affect (NA), and clinical pain. A subset of participants (n = 79) engaged in quantitative sensory testing (QST). State PA and NA were assessed prior to administration of stimuli that induced suprathreshold pain and temporal summation. Multilevel modeling and multiple regression evaluated associations of affect and pain as a function of valence (i.e., positive versus negative) and stability (i.e., stable versus state). Results: In the diary, stable NA (B = -.63, standard error [SE] = .13, p < .001) was a stronger predictor of clinical KOA pain than stable PA (B = -.18, SE = .11, p = .091), and state PA (B = -.09, p < .001) was a stronger predictor of concurrent daily clinical pain than state NA (B = .04, SE = .02, p = .068). In the laboratory, state PA (B = -.05, SE = .02, p = .042), but not state NA (p = .46), predicted diminished temporal summation of mechanical pain. Conclusions: Stable NA is more predictive of clinical pain than stable PA, whereas state PA is more predictive of both clinical and laboratory pain than state NA. The findings suggest that dynamic affect-pain processes in the field may reflect individual differences in central pain facilitation.
C1 [Finan, Patrick H.; Smith, Michael T.] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21224 USA.
[Quartana, Phillip J.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD USA.
RP Finan, PH (reprint author), Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, 5510 Nathan Shock Dr,Suite 100, Baltimore, MD 21224 USA.
EM pfinan1@jhu.edu
FU NIH [R01 AR05487, R01AR059410, T32 NS070201]
FX Funding for work on the current study was provided by NIH R01 AR05487
(M.T.S.), NIH R01AR059410 (M.T.S.), and NIH T32 NS070201 (P.H.F.). The
authors declare no conflicts of interest.
NR 68
TC 13
Z9 14
U1 4
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JUN
PY 2013
VL 75
IS 5
BP 463
EP 470
DI 10.1097/PSY.0b013e31828ef1d6
PG 8
WC Psychiatry; Psychology; Psychology, Multidisciplinary
SC Psychiatry; Psychology
GA 300MO
UT WOS:000330468200005
PM 23697467
ER
PT J
AU Crete, JE
Anasti, JN
AF Crete, Joan E.
Anasti, James N.
TI Diagnosis of gestational diabetes mellitus: Can we avoid the glucose
challenge test?
SO JOURNAL OF THE AMERICAN ASSOCIATION OF NURSE PRACTITIONERS
LA English
DT Article
DE Diabetes; risk factors; screening; obstetrics and gynecology (OB/GYN)
ID SCREENING-TESTS; CRITERIA; PREGNANCY; GUIDELINES; MANAGEMENT
AB Objective: To identify risk factors for gestational diabetes mellitus (GDM) in patients who had either a normal or abnormal glucose tolerance test (GTT) after failing the initial glucose challenge test (GCT). If identified, consideration can be given to circumvent the glucose challenge test for those at risk.
Data sources: A chart review was performed on 557 patients with abnormal GCT, 278 had an abnormal GTT (cases), and 279 had normal GTT (controls). The following risk factors were extracted: patients' age, body mass index (BMI), ethnicity, selected personal history, and family history. A primary logistic regression and secondary exploratory logistic regression were used to analyze the data.
Conclusions: Of the risk factors reviewed age, BMI, and prior history of GDM were predictive of GDM in the current pregnancy. Age 30-34 had an odds ratio (OR) of 1.95, 95% confidence interval (CI) [1.25,3.05] and over 35 had an OR 3.87 CI [2.12,7.05]. BMI over 30 had an OR 1.95, CI [1.25,3.05] and prior GDM had an OR 2.82 CI [1.55,5.13]. The combination of age and BMI had a significant OR, but not a significant increase over individual risk factors.
Implications for practice: Screening by risk factors to circumvent glucose challenge testing may cause unnecessary testing and cost.
C1 [Crete, Joan E.; Anasti, James N.] St Lukes Hosp & Hlth Network, Dept Obstet & Gynecol, Bethlehem, PA USA.
RP Crete, JE (reprint author), Tripler Army Med Ctr, Dept Obstet & Gynecol, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM joan.e.crete@us.army.mil
NR 26
TC 4
Z9 4
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2327-6886
EI 2327-6924
J9 J AM ASSOC NURSE PRA
JI J. Am. Assoc. Nurs. Pract.
PD JUN
PY 2013
VL 25
IS 6
BP 329
EP 333
DI 10.1111/j.1745-7599.2012.00792.x
PG 5
WC Health Care Sciences & Services; Nursing
SC Health Care Sciences & Services; Nursing
GA 296GR
UT WOS:000330173700008
PM 24170598
ER
PT J
AU Belenkiy, S
Berry, J
Batchinsky, A
Kendrick, C
Necsoiu, C
Salinas, J
Cancio, L
AF Belenkiy, S.
Berry, J.
Batchinsky, A.
Kendrick, C.
Necsoiu, C.
Salinas, J.
Cancio, L.
TI UTILITY OF END-TIDAL AND TRANSCUTANEOUS CARBON DIOXIDE MONITORING DURING
LETHAL HEMORRHAGIC SHOCK
SO SHOCK
LA English
DT Meeting Abstract
CT 36th Annual Conference of Shock-Society on Shock
CY JUN 01-04, 2013
CL San Diego, CA
SP Shock Soc
C1 [Belenkiy, S.; Berry, J.; Batchinsky, A.; Kendrick, C.; Necsoiu, C.; Salinas, J.; Cancio, L.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Belenkiy, S.; Berry, J.; Kendrick, C.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2013
VL 39
SU 2
BP 44
EP 45
PG 2
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA 297JK
UT WOS:000330251500090
ER
PT J
AU Dubick, MA
Darlington, DN
Barr, JJ
Grubbs, DL
Schwacha, MG
Cap, AP
AF Dubick, M. A.
Darlington, D. N.
Barr, J. J.
Grubbs, D. L.
Schwacha, M. G.
Cap, A. P.
TI EFFECTS OF POLYTRAUMA, HEMORRHAGE AND RESULTANT COAGULOPATHY ON
INFLAMMATORY AND OXIDANT STRESS MARKERS IN RAT TISSUES
SO SHOCK
LA English
DT Meeting Abstract
CT 36th Annual Conference of Shock-Society on Shock
CY JUN 01-04, 2013
CL San Diego, CA
SP Shock Soc
C1 [Dubick, M. A.; Darlington, D. N.; Barr, J. J.; Grubbs, D. L.; Schwacha, M. G.; Cap, A. P.] US Army, Inst Surg Res, San Antonio, TX USA.
[Dubick, M. A.; Schwacha, M. G.; Cap, A. P.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2013
VL 39
SU 2
BP 44
EP 44
PG 1
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA 297JK
UT WOS:000330251500089
ER
PT J
AU Tiba, MH
Draucker, GT
Barbee, RW
Terner, J
Torres, IP
Ward, KR
AF Tiba, M. H.
Draucker, G. T.
Barbee, R. W.
Terner, J.
Torres Filho, I. P.
Ward, K. R.
TI PERFORMANCE OF TISSUE HEMOGLOBIN OXYGEN SATURATION AS MEASURED BY
RESONANCE RAMAN SPECTROSCOPY AND NEAR INFRARED SPECTROSCOPY COMPARED TO
MIXED VENOUS HEMOGLOBIN OXYGEN SATURATION AND SYSTEMIC LACTATE LEVELS
DURING HEMORRHAGE
SO SHOCK
LA English
DT Meeting Abstract
CT 36th Annual Conference of Shock-Society on Shock
CY JUN 01-04, 2013
CL San Diego, CA
SP Shock Soc
C1 [Tiba, M. H.; Draucker, G. T.; Ward, K. R.] Univ Michigan, Ann Arbor, MI 48109 USA.
[Tiba, M. H.; Draucker, G. T.; Ward, K. R.] Michigan Ctr Integrat Res Crit Care, Ann Arbor, MI USA.
[Barbee, R. W.; Terner, J.] Virginia Commonwealth Univ, Richmond, VA USA.
[Torres Filho, I. P.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2013
VL 39
SU 2
BP 56
EP 56
PG 1
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA 297JK
UT WOS:000330251500123
ER
PT J
AU Zhang, Q
Rani, M
Cap, AP
Darlington, DN
Schwacha, MG
AF Zhang, Q.
Rani, M.
Cap, A. P.
Darlington, D. N.
Schwacha, M. G.
TI BURN INCREASES CIRCULATING LEVELS OF DAMAGE-ASSOCIATED MOLECULAR
PATTERNS (DAMPS)
SO SHOCK
LA English
DT Meeting Abstract
CT 36th Annual Conference of Shock-Society on Shock
CY JUN 01-04, 2013
CL San Diego, CA
SP Shock Soc
C1 [Zhang, Q.; Rani, M.; Cap, A. P.; Schwacha, M. G.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
[Cap, A. P.; Darlington, D. N.; Schwacha, M. G.] US Army Inst Surg Res, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2013
VL 39
SU 2
BP 57
EP 57
PG 1
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA 297JK
UT WOS:000330251500125
ER
PT J
AU Holloway, TL
Rani, M
Craig, T
Zhang, Q
Cap, AP
Schwacha, MG
AF Holloway, T. L.
Rani, M.
Craig, T.
Zhang, Q.
Cap, A. P.
Schwacha, M. G.
TI TOLL-LIKE RECEPTOR INDUCED RESPONSES BY CIRCULATING LEUKOCYTES ARE
SUPPRESSED IN TRAUMA ICU PATIENTS
SO SHOCK
LA English
DT Meeting Abstract
CT 36th Annual Conference of Shock-Society on Shock
CY JUN 01-04, 2013
CL San Diego, CA
SP Shock Soc
C1 [Holloway, T. L.; Rani, M.; Craig, T.; Zhang, Q.; Cap, A. P.; Schwacha, M. G.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
[Cap, A. P.; Schwacha, M. G.] US Army Inst Surg Res, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2013
VL 39
SU 2
BP 81
EP 81
PG 1
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA 297JK
UT WOS:000330251500191
ER
PT J
AU Berry, JS
Batchinsky, A
Belenkiy, S
Kendrick, C
Necsoiu, C
Ivey, KM
Thomas, D
Dubick, MA
Salinas, J
Rasmussen, TE
Cancio, L
AF Berry, J. S.
Batchinsky, A.
Belenkiy, S.
Kendrick, C.
Necsoiu, C.
Ivey, K. M.
Thomas, D.
Dubick, M. A.
Salinas, J.
Rasmussen, T. E.
Cancio, L.
TI A PORCINE MODEL OF EXSANGUINATION CARDIAC ARREST
SO SHOCK
LA English
DT Meeting Abstract
CT 36th Annual Conference of Shock-Society on Shock
CY JUN 01-04, 2013
CL San Diego, CA
SP Shock Soc
C1 [Berry, J. S.; Batchinsky, A.; Belenkiy, S.; Kendrick, C.; Necsoiu, C.; Ivey, K. M.; Thomas, D.; Dubick, M. A.; Salinas, J.; Rasmussen, T. E.; Cancio, L.] US Army, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2013
VL 39
SU 2
BP 92
EP 92
PG 1
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA 297JK
UT WOS:000330251500220
ER
PT J
AU Rani, M
Galvan, EM
Zhang, Q
Schwacha, MG
AF Rani, M.
Galvan, E. M.
Zhang, Q.
Schwacha, M. G.
TI TRAUMA-HEMORRHAGE-INDUCED ACUTE LUNG INJURY IS ASSOCIATED WITH
T-CELL-MEDIATED TH2 AND TH17 IMMUNE RESPONSES
SO SHOCK
LA English
DT Meeting Abstract
CT 36th Annual Conference of Shock-Society on Shock
CY JUN 01-04, 2013
CL San Diego, CA
SP Shock Soc
C1 [Rani, M.; Galvan, E. M.; Zhang, Q.; Schwacha, M. G.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
[Schwacha, M. G.] US Army Inst Surg Res, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2013
VL 39
SU 2
BP 93
EP 93
PG 1
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA 297JK
UT WOS:000330251500223
ER
PT J
AU Baer, LA
Wu, X
Wolf, S
Wade, C
AF Baer, L. A.
Wu, X.
Wolf, S.
Wade, C.
TI ADIPOKINE RESPONSES TO BURN AND DISUSE IN RATS
SO SHOCK
LA English
DT Meeting Abstract
CT 36th Annual Conference of Shock-Society on Shock
CY JUN 01-04, 2013
CL San Diego, CA
SP Shock Soc
C1 [Baer, L. A.; Wade, C.] Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA.
[Wu, X.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
[Wolf, S.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2013
VL 39
SU 2
BP 95
EP 95
PG 1
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA 297JK
UT WOS:000330251500228
ER
PT J
AU Martini, AK
Moreno, C
Guerra, J
Martini, W
Dubick, MA
AF Martini, A. K.
Moreno, C.
Guerra, J.
Martini, W.
Dubick, M. A.
TI DOSE RESPONSES OF ACETAMINOPHEN AND MELOXICAM ON PLATELET AGGREGATION
AND COAGULATION IN HUMAN BLOOD IN VITRO
SO SHOCK
LA English
DT Meeting Abstract
CT 36th Annual Conference of Shock-Society on Shock
CY JUN 01-04, 2013
CL San Diego, CA
SP Shock Soc
C1 [Martini, A. K.] Rice Univ, Houston, TX USA.
[Moreno, C.; Guerra, J.; Martini, W.; Dubick, M. A.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2013
VL 39
SU 2
BP 96
EP 97
PG 2
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA 297JK
UT WOS:000330251500232
ER
PT J
AU Martini, W
Cortex, D
Dubick, MA
AF Martini, W.
Cortex, D.
Dubick, M. A.
TI RESUSCITATION EFFECTS OF LACTATED RINGER'S SOLUTION AND NORMAL SALINE ON
EARLY HEPATIC SYNTHESIS FOLLOWING SEVERE HEMORRHAGIC SHOCK IN PIGS
SO SHOCK
LA English
DT Meeting Abstract
CT 36th Annual Conference of Shock-Society on Shock
CY JUN 01-04, 2013
CL San Diego, CA
SP Shock Soc
C1 [Martini, W.; Cortex, D.; Dubick, M. A.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2013
VL 39
SU 2
BP 104
EP 104
PG 1
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA 297JK
UT WOS:000330251500252
ER
PT J
AU Seibert, J
Roofe, SB
AF Seibert, Jared
Roofe, Scott B.
TI Pilot Study of Dexmedetomidine in Promoting Patient Comfort without
Airway Compromise during Awake Tracheotomy
SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY
LA English
DT Article
DE awake tracheotomy; dexmedetomidine; patient safety; difficult airway
ID SEDATION
C1 [Seibert, Jared; Roofe, Scott B.] US Army, Tripler Army Med Ctr, Honolulu, HI 96859 USA.
RP Seibert, J (reprint author), US Army, Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM Jared.seibert@amedd.army.mil
NR 5
TC 0
Z9 0
U1 0
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0194-5998
EI 1097-6817
J9 OTOLARYNG HEAD NECK
JI Otolaryngol. Head Neck Surg.
PD JUN
PY 2013
VL 148
IS 6
BP 1051
EP 1053
DI 10.1177/0194599813484448
PG 3
WC Otorhinolaryngology; Surgery
SC Otorhinolaryngology; Surgery
GA 285ZD
UT WOS:000329433000025
PM 23554116
ER
PT J
AU Ward, MP
Sperry, JH
Weatherhead, PJ
AF Ward, Michael P.
Sperry, Jinelle H.
Weatherhead, Patrick J.
TI Evaluation of Automated Radio Telemetry for Quantifying Movements and
Home Ranges of Snakes
SO JOURNAL OF HERPETOLOGY
LA English
DT Article
ID EASTERN MASSASAUGA RATTLESNAKES; HUMAN DISTURBANCE; ESTIMATORS; SIZE;
RADIOTELEMETRY; ECOLOGY
AB We evaluated an automated telemetry system that can dramatically increase the amount of activity and spatial data collected for snakes. We developed methods for analyzing data from single automated receiving units (ARUs) and ARU arrays, compared results from ARUs with conventional hand tracking, and assessed previously untested assumptions used in conventional telemetry, using data from ratsnakes (Pantherophis spp.) in Texas and Illinois. ARU data indicated that ratsnakes spent most of their time in small home ranges (mean = 25 ha) but engaged in forays of up to 1.5 km from their core-use areas, suggesting this species may engage in central place foraging. Forays inflated home-range sizes greatly if areas were estimated using minimum convex polygons rather than 95% kernels. Large numbers of locations generated by ARUs produce more reliable home-range estimates than those from hand tracking. ARU data indicated that snakes moved in response to observers during hand tracking. Daily hand tracking produced reliable estimates of distances moved but underestimated distances by a factor of 4 when snakes were tracked every 5 days. Drawbacks of ARUs are that the error associated with individual locations exceeds that for hand-tracked locations and that the costs exceed those for hand tracking. Automated receivers can increase data greatly from radio-tracked snakes, providing novel insights unavailable from conventional hand tracking. There are drawbacks to this technology, some of which will vary among study species; therefore, researchers should evaluate the appropriateness of the technology for both the study species and the questions being asked.
C1 [Ward, Michael P.; Weatherhead, Patrick J.] Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA.
[Ward, Michael P.] Univ Illinois, Illinois Nat Hist Survey, Champaign, IL 61802 USA.
[Sperry, Jinelle H.] Engineer Res & Dev Ctr, Champaign, IL 61826 USA.
RP Ward, MP (reprint author), Univ Illinois, Dept Nat Resources & Environm Sci, 1102 S Goodwin Ave, Urbana, IL 61801 USA.
EM mpward@illinois.edu
FU U.S. Army Fort Hood Natural Resources Branch; U.S. Army Corps of
Engineers, Engineer Research and Development Center
FX For the Texas portion of this project, we thank the U.S. Army Fort Hood
Natural Resources Branch and the U.S. Army Corps of Engineers, Engineer
Research and Development Center for funding, particularly J. Cornelius,
T. Hayden, and T. Buchanan. For the Illinois portion, we thank M.
Alessi, H. Fraser, K. Sierzega, S. Chiavacci, E. Swenson, T. Dallas, T.
Beveroth, A. Raim, Vermilion County Conservation District, and the
Illinois Department of Natural Resources for assistance in the field and
access of the study area. We thank T. J. Benson for assistance with
statistical analyses.
NR 28
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Z9 16
U1 4
U2 48
PU SOC STUDY AMPHIBIANS REPTILES
PI ST LOUIS
PA C/O ROBERT D ALDRIDGE, ST LOUIS UNIV, DEPT BIOLOGY, 3507 LACLEDE, ST
LOUIS, MO 63103 USA
SN 0022-1511
EI 1937-2418
J9 J HERPETOL
JI J. Herpetol.
PD JUN
PY 2013
VL 47
IS 2
BP 337
EP 345
DI 10.1670/12-018
PG 9
WC Zoology
SC Zoology
GA 264TI
UT WOS:000327903500021
ER
PT J
AU Zheng, ZL
Badawy, T
Henein, N
Sattler, E
AF Zheng, Ziliang
Badawy, Tamer
Henein, Naeim
Sattler, Eric
TI Investigation of Physical and Chemical Delay Periods of Different Fuels
in the Ignition Quality Tester
SO JOURNAL OF ENGINEERING FOR GAS TURBINES AND POWER-TRANSACTIONS OF THE
ASME
LA English
DT Article
AB This paper investigates the physical and chemical ignition delay (ID) periods in the constant volume combustion chamber of the Ignition Quality Tester (IQT). IQT was used to determine the derived cetane number (DCN) according to ASTM D6890-10a standards. The fuels tested were ultra low sulfur diesel (ULSD), jet propellant-8 (JP-8), and two synthetic fuels of Sasol IPK and F-T SPK (S-8). A comparison was made between the DCN and cetane number (CN) determined according to ASTM-D613 standards. Tests were conducted under steady state conditions at a constant pressure of 21 bars and various air temperatures ranging from 778K to 848 K. The rate of heat release (RHR) was calculated from the measured pressure trace, and a detailed analysis of the RHR trace was made particularly for the auto-ignition process. Tests were conducted to determine the physical and chemical delay periods by comparing results obtained from two tests. In the first test, the fuel was injected into air according to ASTM standards. In the second test, the fuel was injected into nitrogen. The point at which the two resultant pressure traces separated was considered to be the end of the physical delay period. The effects of the charge temperature on the total ID as defined in ASTM D6890-10a standards, as well as on the physical and chemical delays, were determined. It was noticed that the physical delay represented a significant part of the total ID over all the air temperatures covered in this investigation. Arrhenius plots were developed to determine the apparent activation energy for each fuel using different IDs. The first was based on the total ID measured according to ASTM standards. The second was the chemical delay determined in this investigation. The activation energy calculated from the total ID showed higher values for lower CN fuels except Sasol IPK. The activation energy calculated from the chemical delay period showed consistency in the increase of the activation energy with the drop in CN including Sasol IPK. The difference between the two findings could be explained by examining the sensitivity of the physical delay period of different fuels to the change in air temperature.
C1 [Zheng, Ziliang; Badawy, Tamer; Henein, Naeim] Wayne State Univ, Detroit, MI 48202 USA.
[Sattler, Eric] US Army RDECOM TARDEC, Warren, MI 48092 USA.
RP Zheng, ZL (reprint author), Wayne State Univ, Detroit, MI 48202 USA.
EM zhengziliang@gmail.com; Eng.tam@gmail.com; henein@eng.wayne.edu;
eric.r.sattler.civ@mail.mil
FU US Army TARDEC; NAC, US Department of Energy, Next Energy Center and
Automotive Research Center (ARC): A Center of Excellence in Simulation
and Modeling
FX This research was sponsored by US Army TARDEC and NAC, US Department of
Energy, Next Energy Center and Automotive Research Center (ARC): A
Center of Excellence in Simulation and Modeling sponsored by US Army
TARDEC and lead by University of Michigan. Our special thanks are to Pat
Muzzell and N. Johnson of NAC, P. Schihl and L Hoogterp-Decker of
TARDEC, Kapila Wadumesthrige and Elena Florea for their technical
support. We also would like to thank National Renewable Energy Lab,
Wayne State University Center of Automotive Research members for their
help in conducting this research.
NR 42
TC 10
Z9 10
U1 0
U2 8
PU ASME
PI NEW YORK
PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA
SN 0742-4795
EI 1528-8919
J9 J ENG GAS TURB POWER
JI J. Eng. Gas. Turbines Power-Trans. ASME
PD JUN
PY 2013
VL 135
IS 6
AR 061501
DI 10.1115/1.4023607
PG 11
WC Engineering, Mechanical
SC Engineering
GA 241GY
UT WOS:000326155600002
ER
PT J
AU George, SG
Slack, WT
Killgore, KJ
AF George, Steven G.
Slack, William T.
Killgore, K. Jack
TI First Recorded Occurrence of Oncorhynchus mykiss (Rainbow Trout) in
Louisiana
SO SOUTHEASTERN NATURALIST
LA English
DT Article
AB An individual of Oncothynchus mykiss (Rainbow Trout) was collected in a diversion canal of the Mississippi River known as Davis Pond located at river kilometer (RKM) 191.03 in St. Charles Parish near Luling, LA. This locality is the southern-most record for Rainbow Trout in the Mississippi River Basin and represents a range extension of 733.5 RKM south from the previous southern-most locality at Lake Whittington, Bolivar County, MS. The collection we report here also represents the first documented record of Rainbow Trout in Louisiana.
C1 [George, Steven G.; Slack, William T.; Killgore, K. Jack] US Army Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP George, SG (reprint author), US Army Corps Engineers, Engineer Res & Dev Ctr, Environm Lab 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM Steven.G.George@usace.army.mil
OI Killgore, William/0000-0002-5328-0208
FU US Army Corps of Engineers, New Orleans District
FX This project was funded by the US Army Corps of Engineers, New Orleans
District. Field assistance was provided by J.J. Hoover, W.E. Lancaster,
J.P. Kirk, C. Murphy, J.A. Collins, B.R. Lewis. and C. Troxler.
Permission to publish was provided by the Chief of Engineers.
NR 15
TC 0
Z9 0
U1 0
U2 3
PU HUMBOLDT FIELD RESEARCH INST
PI STEUBEN
PA PO BOX 9, STEUBEN, ME 04680-0009 USA
SN 1528-7092
J9 SOUTHEAST NAT
JI Southeast. Nat.
PD JUN
PY 2013
VL 12
IS 2
BP 448
EP 450
DI 10.1656/058.012.0217
PG 3
WC Biodiversity Conservation; Ecology
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA 217RR
UT WOS:000324378200016
ER
PT J
AU Propper, RE
Januszewski, A
Brunye, TT
Christman, SD
AF Propper, Ruth E.
Januszewski, Ashley
Brunye, Tad T.
Christman, Stephen D.
TI Tympanic Membrane Temperature, Hemispheric Activity, and Affect:
Evidence for a Modest Relationship
SO JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES
LA English
DT Article
ID VISUAL-FIELD STIMULATION; ACTIVATION; HANDEDNESS; ASYMMETRY
AB Tympanic membrane temperature (TMT) offers a methodologically simple and noninvasive means to provide a physiological measure of hemispheric activation, although the mechanisms by which it may be related to hemispheric activity are not completely known. Here, the authors examined TMT at baseline and after a mood-induction protocol. They replicate baseline associations between increased absolute difference between left and right TMT and increased anger, and found evidence for a link between increased TMT and increased ipsilateral hemispheric activation after mood-induction. They also found tentative evidence for the existence of right-lateralized emotional hyperthermia after mood-induction.
C1 [Propper, Ruth E.] Montclair State Univ, Dept Psychol, Montclair, NJ USA.
[Januszewski, Ashley] Merrimack Coll, Dept Psychol, N Andover, MA 01845 USA.
[Brunye, Tad T.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA.
[Brunye, Tad T.] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA USA.
[Christman, Stephen D.] Univ Toledo, Dept Psychol, Toledo, OH 43606 USA.
RP Propper, RE (reprint author), Montclair State Univ, Dept Psychol, Montclair, NJ USA.
EM propperr@mail.montclair.edu
FU U.S. Army [W911QY-09-P-0567, W911QY-10-P-0420]
FX This work was supported by U.S. Army Contracts #W911QY-09-P-0567 and
W911QY-10-P-0420. The opinions expressed herein are those of the authors
and not necessarily of the U.S. Army.
NR 17
TC 0
Z9 0
U1 0
U2 5
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 0895-0172
J9 J NEUROPSYCH CLIN N
JI J. Neuropsychiatr. Clin. Neurosci.
PD SUM
PY 2013
VL 25
IS 3
BP 198
EP 204
PG 7
WC Clinical Neurology; Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 215XC
UT WOS:000324243300037
PM 23695535
ER
PT J
AU Hall, LD
Dalton, SR
Fillman, EP
Dohse, L
Elston, DM
AF Hall, Lawrence D.
Dalton, Scott R.
Fillman, Eric P.
Dohse, Lindsay
Elston, Dirk M.
TI Re-examination of Features to Distinguish Polyarteritis Nodosa From
Superficial Thrombophlebitis
SO AMERICAN JOURNAL OF DERMATOPATHOLOGY
LA English
DT Article
DE polyarteritis nodosa; superficial thrombophlebitis; internal elastic
lamina; smooth muscle pattern; elastic fiber pattern; misdiagnosis
ID INTERNAL ELASTIC LAMINA; VARICOSE-VEINS; FIBERS; ARTERY
AB The correct identification of vessel type is crucial in distinguishing cutaneous polyarteritis nodosa from superficial thrombophlebitis. As the treatment and prognosis of these conditions are very different, correct diagnosis is critical, but they have overlapping clinical and histopathologic features, which can sometimes make the distinction difficult. Features commonly used to distinguish an artery from vein include vessel shape and diameter, the presence or absence of an internal elastic lamina, smooth muscle pattern, and the presence or absence of valves. Recently, it has been proposed that the amount and distribution of elastic fibers in the medial muscular layer are the most reliable features to make this distinction. The first part of this study used prosector-identified vessels to determine which of these features is most sensitive and specific for identifying an artery and vein. A total of 19 arteries and 16 veins were dissected from autopsy and amputation specimens. For each specimen, the smooth muscle pattern, elastic fiber pattern, the presence of valves, and the presence or absence of an internal elastic membrane were determined. The quantity of elastic fibers in the muscular wall of each sample was also determined. Although the elastic fiber pattern was the most specific feature in identifying a vein, it suffered from low sensitivity (43.8%). The smooth muscle pattern had the highest combined sensitivity and specificity. In the second part of this study, the histologic features listed above were examined in previously diagnosed cases of superficial thrombophlebitis and arteritis. When inflammation is present within and around the wall of the vessel, all of the studied histologic features become less reliable, and the interobserver reliability of distinguishing arteritis from thrombophlebitis was low. Our findings suggest that no single histopathologic feature is completely reliable and combining the histopathologic features with clinicopathologic correlation is essential for correct vessel identification.
C1 [Hall, Lawrence D.; Dalton, Scott R.; Dohse, Lindsay] Geisinger Med Ctr, Dept Dermatol, Danville, PA 17821 USA.
[Fillman, Eric P.] Brooke Army Med Ctr, Dept Pathol, Ft Sam Houston, TX 78234 USA.
[Elston, Dirk M.] Ackerman Acad Dermatopathol, New York, NY USA.
RP Hall, LD (reprint author), Geisinger Med Ctr, Dept Dermatol, Danville, PA 17821 USA.
EM ldhall@geisinger.edu
NR 13
TC 2
Z9 2
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0193-1091
J9 AM J DERMATOPATH
JI Am. J. Dermatopathol.
PD JUN
PY 2013
VL 35
IS 4
BP 463
EP 471
DI 10.1097/DAD.0b013e3182770a42
PG 9
WC Dermatology
SC Dermatology
GA 150JK
UT WOS:000319386300016
PM 23392132
ER
PT J
AU Torrieri, D
Valenti, MC
AF Torrieri, Don
Valenti, Matthew C.
TI Exclusion and Guard Zones in DS-CDMA Ad Hoc Networks
SO IEEE TRANSACTIONS ON COMMUNICATIONS
LA English
DT Article
DE Spread-spectrum communication; carrier-sense multiaccess; mobile
communications; fading channels
ID WIRELESS NETWORKS; TRANSMISSION CAPACITY; INTERFERENCE
AB The central issue in direct-sequence code-division multiple-access (DS-CDMA) ad hoc networks is the prevention of a near-far problem. This paper considers two types of guard zones that may be used to control the near-far problem: a fundamental exclusion zone and an additional CSMA guard zone that may be established by the carrier-sense multiple-access (CSMA) protocol. In the exclusion zone, no mobiles are physically present, modeling the minimum physical separation among mobiles that is always present in actual networks. Potentially interfering mobiles beyond a transmitting mobile's exclusion zone, but within its CSMA guard zone, are deactivated by the protocol. This paper provides an analysis of DS-CSMA networks with either or both types of guard zones. A network of finite extent with a finite number of mobiles and uniform clustering as the spatial distribution is modeled. The analysis applies a closed-form expression for the outage probability in the presence of Nakagami fading, conditioned on the network geometry. The tradeoffs between exclusion zones and CSMA guard zones are explored for DS-CDMA and unspread networks. The spreading factor and the guard-zone radius provide design flexibility in achieving specified levels of average outage probability and transmission capacity. The advantage of an exclusion zone over a CSMA guard zone is that since the network is not thinned, the number of active mobiles remains constant, and higher transmission capacities can be achieved.
C1 [Torrieri, Don] US Army Res Lab, Adelphi, MD USA.
[Valenti, Matthew C.] W Virginia Univ, Dept Comp Sci & Elect Engn, Morgantown, WV 26506 USA.
RP Torrieri, D (reprint author), US Army Res Lab, Adelphi, MD USA.
EM don.j.torrieri.civ@mail.mil; valenti@ieee.org
OI Valenti, Matthew/0000-0001-6089-0509
FU National Science Foundation [CNS-0750821]; United States Army Research
Laboratory [W911NF-10-0109]
FX M. C. Valenti's contribution was sponsored by the National Science
Foundation under Award No. CNS-0750821, and by the United States Army
Research Laboratory under Contract W911NF-10-0109.
NR 16
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Z9 9
U1 2
U2 10
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0090-6778
J9 IEEE T COMMUN
JI IEEE Trans. Commun.
PD JUN
PY 2013
VL 61
IS 6
BP 2468
EP 2476
DI 10.1109/TCOMM.2013.041113.120714
PG 9
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA 175GO
UT WOS:000321219100033
ER
PT J
AU Mersel, MK
Smith, LC
Andreadis, KM
Durand, MT
AF Mersel, Matthew K.
Smith, Laurence C.
Andreadis, Konstantinos M.
Durand, Michael T.
TI Estimation of river depth from remotely sensed hydraulic relationships
SO WATER RESOURCES RESEARCH
LA English
DT Article
DE hydraulic geometry; river depth; surface water and ocean topography;
SWO; slope break
ID SATELLITE RADAR ALTIMETRY; SYNTHETIC-APERTURE RADAR; WATER-LEVEL
CHANGES; AMAZON FLOODPLAIN; WETLAND DYNAMICS; INUNDATION AREA;
SURFACE-WATER; GEOMETRY; DISCHARGE; BASIN
AB The Surface Water and Ocean Topography (SWOT) radar interferometer satellite mission will provide unprecedented global measurements of water surface elevation (h) for inland water bodies. However, like most remote sensing technologies SWOT will not observe river channel bathymetry below the lowest observed water surface, thus limiting its value for estimating river depth and/or discharge. This study explores if remotely sensed observations of river inundation width and h alone, when accumulated over time, may be used to estimate this unmeasurable flow depth. To test this possibility, synthetic values of h and either cross-sectional flow width (w) or effectivewidth (We, inundation area divided by reach length) are extracted from 1495 previously surveyed channel cross-sections for the Upper Mississippi, Illinois, Rio Grande, and Ganges-Brahmaputra river systems, and from 62 km of continuously acquired sonar data for the Upper Mississippi. Two proposed methods (called "Linear" and "Slope-Break") are tested that seek to identify a small subset of geomorphically "optimal" locations where w or We covary strongly with h, such that they may be usefully extrapolated to estimate mean cross-sectional flow depth (d). While the simplest Linear Method is found to have considerable uncertainty, the Slope-Break Method, identifying locations where two distinct hydraulic relationships are identified (one for moderate to high flows and one for low flows), holds promise. Useful slope breaks were discovered in all four river systems, ranging from 6 (0.04%) to 242 (16%) of the 1495 studied cross-sections, assuming channel bathymetric exposures ranging from 20% to 95% of bankfull conditions, respectively. For all four rivers, the derived depth estimates from the Slope-Break Method have root mean squared errors (RMSEs) of <20% (relative to bankfull mean depth) assuming at least one channel bathymetry exposure of similar to 25% or greater. Based on historic discharge records and HEC-RAS hydraulic modeling, the Upper Mississippi and Rio Grande rivers experience adequate channel exposures at least similar to 60% and similar to 42% of the time, respectively. For the Upper Mississippi, so-called "reach-averaging" (spatial averaging along some predetermined river length) of native-resolution h and We values reduces both RMSE and longitudinal variability in the derived depth estimates, especially at reach-averaging lengths of similar to 1000-2000 m. These findings have positive implications for SWOT and other sensors attempting to estimate river flow depth and/or discharge solely from incomplete, remotely sensed hydraulic variables, and suggest that useful depth retrievals can be obtained within the spatial and temporal constraints of satellite observations.
C1 [Mersel, Matthew K.; Smith, Laurence C.] Univ Calif Los Angeles, Dept Geog, Los Angeles, CA 90024 USA.
[Smith, Laurence C.] Univ Calif Los Angeles, Dept Earth & Space Sci, Los Angeles, CA 90024 USA.
[Andreadis, Konstantinos M.] CALTECH, Jet Prop Lab, Pasadena, CA 91125 USA.
[Durand, Michael T.] Ohio State Univ, Sch Earth Sci, Columbus, OH 43210 USA.
[Durand, Michael T.] Ohio State Univ, Byrd Polar Res Ctr, Columbus, OH 43210 USA.
RP Mersel, MK (reprint author), Cold Reg Res & Engn Lab, RS GIS 103,72 Lyme Rd, Hanover, NH 03755 USA.
EM mmersel@ucla.edu
RI Durand, Michael/D-2885-2013; Smith, Laurence/E-7785-2012
OI Smith, Laurence/0000-0001-6866-5904
FU NASA Physical Oceanography Program [NNX10AE96G]
FX This research was funded by the NASA Physical Oceanography Program
(grant NNX10AE96G), managed by Eric Lindstrom. In situ cross-section
data for the Ganges-Brahmaputra river system was provided by Faissal
Hossain (Tennessee Technical University) as part of a Memorandum of
Understanding between the Institute of Water Modeling-Bangladesh and
Tennessee Technical University. In situ cross-section data for the Rio
Grande (surveyed by Tetra Tech Inc.) and for the Upper Mississippi and
Illinois rivers (surveyed by the U. S. Army Corps of Engineers) was
provided to the authors by Edward Beighley (FM Global). The continuous
in situ bathymetric data set for the Upper Mississippi was provided by
the USGS, as part of the Long Term Resource Monitoring Program. The
authors thank Doug Alsdorf, Paul Bates, and one anonymous reviewer for
their constructive feedback on this paper.
NR 51
TC 19
Z9 19
U1 3
U2 49
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 0043-1397
J9 WATER RESOUR RES
JI Water Resour. Res.
PD JUN
PY 2013
VL 49
IS 6
BP 3165
EP 3179
DI 10.1002/wrcr.20176
PG 15
WC Environmental Sciences; Limnology; Water Resources
SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water
Resources
GA 189BF
UT WOS:000322241300007
ER
PT J
AU Hung, BWK
Kolitz, SE
Ozdaglar, A
AF Hung, Benjamin W. K.
Kolitz, Stephan E.
Ozdaglar, Asuman
TI Optimization-Based Influencing of Village Social Networks in a
Counterinsurgency
SO ACM TRANSACTIONS ON INTELLIGENT SYSTEMS AND TECHNOLOGY
LA English
DT Article
DE Human Factors; Economics; Social network; agent modeling; network
optimization; opinion dynamics; counterinsurgency
AB This article considers the nonlethal targeting assignment problem in the counterinsurgency in Afghanistan, the problem of deciding on the people whom U.S. forces should engage through outreach, negotiations, meetings, and other interactions in order to ultimately win the support of the population in their area of operations. We propose two models: (1) the Afghan counterinsurgency (COIN) social influence model, to represent how attitudes of local leaders are affected by repeated interactions with other local leaders, insurgents, and counterinsurgents, and (2) the nonlethal targeting model, a NonLinear Programming (NLP) optimization formulation that identifies a strategy for assigning k U.S. agents to produce the greatest arithmetic mean of the expected long-term attitude of the population. We demonstrate in an experiment the merits of the optimization model in nonlethal targeting, which performs significantly better than both doctrine-based and random methods of assignment in a large network.
C1 [Hung, Benjamin W. K.] USMA, Dept Math Sci, West Point, NY 10996 USA.
[Kolitz, Stephan E.] Charles Stark Draper Lab, Cambridge, MA USA.
[Ozdaglar, Asuman] MIT, Cambridge, MA 02139 USA.
RP Hung, BWK (reprint author), USMA, Dept Math Sci, 601 Thayer Rd, West Point, NY 10996 USA.
EM benjamin.w.hung@us.army.mil
FU Omar N. Bradley Foundation
FX This research was supported by the Omar N. Bradley Foundation and
Fellowship.
NR 22
TC 0
Z9 0
U1 0
U2 3
PU ASSOC COMPUTING MACHINERY
PI NEW YORK
PA 2 PENN PLAZA, STE 701, NEW YORK, NY 10121-0701 USA
SN 2157-6904
J9 ACM T INTEL SYST TEC
JI ACM Trans. Intell. Syst. Technol.
PD JUN
PY 2013
VL 4
IS 3
AR UNSP 52
DI 10.1145/2483669.2483685
PG 22
WC Computer Science, Artificial Intelligence; Computer Science, Information
Systems
SC Computer Science
GA 175IH
UT WOS:000321223600016
ER
PT J
AU Walker, W
AF Walker, Wickliffe
TI A Border Incident
SO FIDDLEHEAD
LA English
DT Fiction, Creative Prose
C1 [Walker, Wickliffe] US Army, Adelphi, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU UNIV NEW BRUNSWICK
PI FREDERICTON
PA DEPT ENGLISH, CAMPUS HOUSE, PO BOX 4400, FREDERICTON, NB E3B 5A3, CANADA
SN 0015-0630
J9 FIDDLEHEAD
JI Fiddlehead
PD SUM
PY 2013
IS 256
BP 114
EP 125
PG 12
WC Literary Reviews
SC Literature
GA 191SA
UT WOS:000322431700014
ER
PT J
AU Aram, S
Singh, R
Dinavahi, SPG
AF Aram, Shawn
Singh, Rajneesh
Dinavahi, Surya P. G.
TI CFD Analysis of Flapping Wings in Ultra-Low Reynolds Number Regime
SO INTERNATIONAL JOURNAL OF MICRO AIR VEHICLES
LA English
DT Article
AB Computational simulations are conducted to investigate the fluid dynamics of flapping wings at ultra-low Reynolds numbers for micro-aerial vehicle applications. Rigid solid wing and 'comb'-like of the same planform and the equal thicknesses are considered in the current study. Incompressible flow simulations are carried out to compute flowfield and aerodynamic forces on the wings for two types of wing kinematic motions. A parametric study of geometric and kinematic parameters is also conducted to compare the two wings. The aerodynamic forces for Solid wing and the Comb wing are found to be quite similar at lower Reynolds number however the detailed examination of the forces showed that the force generation mechanisms on the two wings are quite different. Analysis suggests that the Comb wings can provide a significant weight savings with a minimal loss in the aerodynamic performance for ultra-low Reynolds number applications.
C1 [Aram, Shawn] ORAU, Aberdeen Proving Ground, MD 21005 USA.
[Singh, Rajneesh] Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Dinavahi, Surya P. G.] Lockheed Martin Co, Aberdeen Proving Ground, MD 21005 USA.
RP Aram, S (reprint author), ORAU, Aberdeen Proving Ground, MD 21005 USA.
NR 5
TC 0
Z9 0
U1 0
U2 9
PU MULTI-SCIENCE PUBL CO LTD
PI BRENTWOOD
PA 5 WATES WAY, BRENTWOOD CM15 9TB, ESSEX, ENGLAND
SN 1756-8293
J9 INT J MICRO AIR VEH
JI Int. J. Micro Air Veh.
PD JUN
PY 2013
VL 5
IS 2
BP 93
EP 107
DI 10.1260/1756-8293.5.2.93
PG 15
WC Engineering, Aerospace
SC Engineering
GA 190CM
UT WOS:000322315200001
ER
PT J
AU Kane, JR
Ayers, P
Howard, H
Anderson, A
Koch, D
AF Kane, James R.
Ayers, Paul
Howard, Heidi
Anderson, Alan
Koch, Daniel
TI Multipass coefficients for terrain impacts based on military vehicle
type, size and dynamic operating properties
SO JOURNAL OF TERRAMECHANICS
LA English
DT Article
DE Multipass; Tracked; Wheeled; Military lands; Predictive modeling
AB Quantification of multipass vehicle impacts is needed to determine terrain disturbance during military training. This study, conducted at Fort Riley, Kansas on a clay loam soil, evaluated the multipass terrain impacts of four military vehicles: the M1A1 Main Battle Tank, M998 HMMWV, M985 HEMTT, and M113 APC. Disturbed width and impact severity were assessed along 14 spirals subjected to a maximum of eight passes for a total of 696 impact points. Project goals included evaluating vegetation impacts by tracked and wheeled military vehicles across multiple passes in order to develop coefficients allowing more accurate predictive modeling of vehicle multipass impacts. Multiple passes produce increased vegetative impacts, with multipass coefficients (MPC) ranging from 0.98 to 4.44 depending on vehicle type, size and turn severity. Tracked vehicles were found to have a higher multipass coefficient than wheeled vehicles, with multipass coefficients increasing with vehicle weight and the sharpness of turns. The components of a more theoretical and universal multipass vehicle impact model are discussed. Understanding multipass dynamics will allow land managers to determine the extent and severity of terrain impacts on military training areas and quickly evaluate vehicle environmental impacts when used in conjunction with a GPS-based vehicle tracking system (VTS). (C) 2013 ISTVS. Published by Elsevier Ltd. All rights reserved.
C1 [Kane, James R.; Ayers, Paul] Univ Tennessee, Dept Biosyst Engn & Soil Sci, Knoxville, TN 37996 USA.
[Howard, Heidi; Anderson, Alan; Koch, Daniel] US Army Corps Engineers, Erdc, CERL, Construct Engn Res Lab,Engineers Engineer Res & D, Champaign, IL 61826 USA.
RP Kane, JR (reprint author), Univ Tennessee, Dept Biosyst Engn & Soil Sci, 2506 EJ Chapman Dr,Ste 314, Knoxville, TN 37996 USA.
EM jkane745@yahoo.com; pdayers@utk.edu; heidi.r.howard@usace.army.mil;
alan.b.anderson@usace.army.mil; daniel.j.koch@usace.army.mil
FU Environmental Security Technology Certification Program (ESTCP)
FX We acknowledge the Environmental Security Technology Certification
Program (ESTCP) for providing financial support for this study. We also
acknowledge and thank installation staff at Fort Riley for assisting
with coordination and data collection.
NR 16
TC 2
Z9 2
U1 0
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4898
J9 J TERRAMECHANICS
JI J. Terramech.
PD JUN
PY 2013
VL 50
IS 3
BP 175
EP 183
DI 10.1016/j.jterra.2013.04.001
PG 9
WC Engineering, Environmental
SC Engineering
GA 190RR
UT WOS:000322358400003
ER
PT J
AU Snider, KF
Halpern, BH
Rendon, RG
Kidalov, MV
AF Snider, Keith F.
Halpern, Barton H.
Rendon, Rene G.
Kidalov, Max V.
TI Corporate social responsibility and public procurement: How supplying
government affects managerial orientations
SO JOURNAL OF PURCHASING AND SUPPLY MANAGEMENT
LA English
DT Article
DE Corporate social responsibility; Public procurement; Government
purchasing; Contracting
ID STAKEHOLDER THEORY; COMPETITIVE ADVANTAGE; INSTITUTIONAL THEORY; CHAIN
MANAGEMENT; UNITED-STATES; PERFORMANCE; BUSINESS; IMPLICIT; INDUSTRY;
DRIVERS
AB How does government drive the corporate social responsibility of firms that supply it with goods and services? This paper reviews relevant theory and practice to describe ways in which public procurement shapes corporate social responsibility, and it builds upon theory to develop testable propositions to describe these influences. Using the case of U.S. defense procurement, statistical analysis indicates a significant relationship between the extent to which firms engage in defense procurement and the corporate social responsibility orientations of their managers. The findings have application both for social responsibility theory and for public procurement policy and practice. Published by Elsevier Ltd.
C1 [Snider, Keith F.; Rendon, Rene G.; Kidalov, Max V.] USN, Postgrad Sch, Grad Sch Business & Publ Policy, Monterey, CA 93943 USA.
[Halpern, Barton H.] USA, Attn RDAR EIJ, ARDEC, Picatinny Arsenal, NJ 07806 USA.
RP Snider, KF (reprint author), USN, Postgrad Sch, Grad Sch Business & Publ Policy, 555 Dyer Rd, Monterey, CA 93943 USA.
EM ksnider@nps.edu
NR 85
TC 6
Z9 6
U1 2
U2 33
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1478-4092
J9 J PURCH SUPPLY MANAG
JI J. Purch. Supply Manag.
PD JUN
PY 2013
VL 19
IS 2
BP 63
EP 72
DI 10.1016/j.pursup.2013.01.001
PG 10
WC Management
SC Business & Economics
GA 185AE
UT WOS:000321936800003
ER
PT J
AU Choi, YS
Berry-Caban, C
Nance, J
AF Choi, Y. Sammy
Berry-Caban, Cristobal
Nance, Julie
TI Telemedicine in paediatric patients with poorly controlled type 1
diabetes
SO JOURNAL OF TELEMEDICINE AND TELECARE
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIAL; GLYCEMIC CONTROL; SUPPORT; ADOLESCENTS;
MANAGEMENT; CHILDREN; SYSTEM; TIME; CARE
AB We conducted a retrospective study of a telemedicine clinic for paediatric patients with poorly controlled type 1 diabetes. Thirty-one patients (mean age 12 years) were enrolled into the clinic. After an initial visit, a group messaging system was provided to allow communication with the diabetic team which consisted of a diabetic provider, diabetic educator, insulin pump trainer and dietician. Patients and parents were encouraged to make all contacts by electronic means. For urgent matters, direct paging access was provided to the diabetic team. Adjustments in insulin dosing were accomplished via automated web-based communication or email between patient and provider. Compared to baseline, the HbA(1c) levels were significantly lower at 3 months (9.1% vs. 11.1%, P < 0.05) and 6.5 months (9.5% vs. 11.1%, P < 0.05). There were no significant differences in HbA(1c) levels for different age categories, insulin delivery methods or number of telemedicine encounters. The study showed that while telemedicine was effective in lowering HbA1c levels, it did not achieve optimum control.
C1 [Choi, Y. Sammy] Dept Med, Ft Bragg, NC 28310 USA.
[Choi, Y. Sammy] Dept Pediat, Ft Bragg, NC 28310 USA.
[Berry-Caban, Cristobal] Clin Invest Serv, Ft Bragg, NC USA.
[Nance, Julie] Sentara Careplex Hosp, Diabet Educ Program, Hampton, VA USA.
RP Choi, YS (reprint author), Dept Med, Ft Bragg, NC 28310 USA.
EM young.choi@amedd.army.mil
NR 17
TC 2
Z9 2
U1 2
U2 9
PU ROYAL SOC MEDICINE PRESS LTD
PI LONDON
PA 1 WIMPOLE STREET, LONDON W1G 0AE, ENGLAND
SN 1357-633X
J9 J TELEMED TELECARE
JI J. Telemed. Telecare
PD JUN
PY 2013
VL 19
IS 4
BP 219
EP 221
DI 10.1258/jtt.2012.120506
PG 3
WC Health Care Sciences & Services
SC Health Care Sciences & Services
GA 185EZ
UT WOS:000321949700008
PM 23401606
ER
PT J
AU Dawson, C
Trahan, CJ
Kubatko, EJ
Westerink, JJ
AF Dawson, Clint
Trahan, Corey Jason
Kubatko, Ethan J.
Westerink, Joannes J.
TI A parallel local timestepping Runge-Kutta discontinuous Galerkin method
with applications to coastal ocean modeling
SO COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
LA English
DT Article
DE Local timestepping; Multirate methods; Shallow water equations;
Runge-Kutta discontinuous Galerkin methods; Tidal flows; Hurricane storm
surge
ID SHALLOW-WATER EQUATIONS; CONSERVATION-LAWS; VARYING TIME; SCHEMES;
INTEGRATION; REFINEMENT
AB Geophysical flows over complex domains often encompass both coarse and highly resolved regions. Approximating these flows using shock-capturing methods with explicit timestepping gives rise to a Courant-Friedrichs-Lewy (CFL) timestep constraint. This approach can result in small global timesteps often dictated by flows in small regions, vastly increasing computational effort over the whole domain. One approach for coping with this problem is to use locally varying timesteps. In previous work, we formulated a local timestepping (LTS) method within a Runge-Kutta discontinuous Galerkin framework and demonstrated the accuracy and efficiency of this method on serial machines for relatively small-scale shallow water applications. For more realistic models involving large domains and highly complex physics, the LTS method must be parallelized for multi-core parallel computers. Furthermore, additional physics such as strong wind forcing can effect the choice of local timesteps. In this paper, we describe a parallel LTS method, parallelized using domain decomposition and MPI. We demonstrate the method on tidal flows and hurricane storm surge applications in the coastal regions of the Western North Atlantic Ocean. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Dawson, Clint] Univ Texas Austin, Inst Computat Engn & Sci, Austin, TX 78712 USA.
[Trahan, Corey Jason] Coastal & Hydraul Lab, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Kubatko, Ethan J.] Ohio State Univ, Dept Civil Environm & Geodet Engn, Columbus, OH 43210 USA.
[Westerink, Joannes J.] Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, Notre Dame, IN 46556 USA.
RP Dawson, C (reprint author), Univ Texas Austin, Inst Computat Engn & Sci, Austin, TX 78712 USA.
EM clint@ices.utexas.edu; ctrahan@drc.com; kubatko.3@osu.edu; jjw@nd.edu
FU National Science Foundation [DMS-1217071, DMS-0915223, OCI-0746232,
DMS-0915118, DMS-1217218]
FX Author C. Dawson acknowledges the support of National Science Foundation
Grants DMS-1217071 and DMS-0915223. J. Westerink acknowledges the
support of National Science Foundation Grant OCI-0746232, and E. Kubatko
acknowledges National Science Foundation Grants DMS-0915118 and
DMS-1217218.
NR 35
TC 9
Z9 9
U1 0
U2 12
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0045-7825
EI 1879-2138
J9 COMPUT METHOD APPL M
JI Comput. Meth. Appl. Mech. Eng.
PD JUN 1
PY 2013
VL 259
BP 154
EP 165
DI 10.1016/j.cma.2013.03.015
PG 12
WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary
Applications; Mechanics
SC Engineering; Mathematics; Mechanics
GA 170GH
UT WOS:000320837900012
ER
PT J
AU Stratman, K
Overholt, WA
Cuda, JP
Netherland, MD
Wilson, PC
AF Stratman, K.
Overholt, W. A.
Cuda, J. P.
Netherland, M. D.
Wilson, P. C.
TI THE DIVERSITY OF CHIRONOMIDAE ASSOCIATED WITH HYDRILLA IN FLORIDA, WITH
SPECIAL REFERENCE TO CRICOTOPUS LEBETIS (DIPTERA: CHIRONOMIDAE)
SO FLORIDA ENTOMOLOGIST
LA English
DT Editorial Material
DE abundance; biological control; distribution; herbivores; Shannon Index;
species richness
ID LARVAL CHIRONOMIDAE; VERTICILLATA
AB The chironomid community associated with hydrilla tips in Florida was diverse, including 16 species of herbivores, detritivores and predators. Cricotopus lebetis, an herbivore of hydrilla, was found in 3 of 6 sampled water bodies, but its abundance, and that of the other midge species, was low.
C1 [Stratman, K.; Overholt, W. A.; Wilson, P. C.] Univ Florida, Biol Control Res & Containment Lab, Indian River Res & Educ Ctr, Ft Pierce, FL 34945 USA.
[Cuda, J. P.] Univ Florida, Dept Entomol & Nematol, Gainesville, FL 32611 USA.
[Netherland, M. D.] United States Army Engineer Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA.
RP Overholt, WA (reprint author), Univ Florida, Biol Control Res & Containment Lab, Indian River Res & Educ Ctr, Ft Pierce, FL 34945 USA.
EM billover@ufl.edu
NR 19
TC 4
Z9 4
U1 1
U2 9
PU FLORIDA ENTOMOLOGICAL SOC
PI LUTZ
PA 16125 E LAKE BURRELL DR, LUTZ, FL 33548 USA
SN 0015-4040
J9 FLA ENTOMOL
JI Fla. Entomol.
PD JUN
PY 2013
VL 96
IS 2
BP 654
EP 657
PG 4
WC Entomology
SC Entomology
GA 168VY
UT WOS:000320737200049
ER
PT J
AU Grzegorczyk, TM
Barrowes, BE
AF Grzegorczyk, Tomasz M.
Barrowes, Benjamin E.
TI Real-Time Processing of Electromagnetic Induction Dynamic Data Using
Kalman Filters for Unexploded Ordnance Detection
SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
LA English
DT Article
DE Electromagnetic induction (EMI); Kalman filters (KFs); MetalMapper
sensor; second-version Man Portable Vector (MPV-II) sensor; real-time
systems; unexploded ordnance (UXO)
ID UXO DISCRIMINATION; COMPONENT ANALYSIS; CLASSIFICATION; SENSOR;
IDENTIFICATION; UNCERTAINTY; OBJECTS; MODEL
AB The current procedure to detect and identify unexploded ordnance (UXO) using electromagnetic induction (EMI) time-domain sensors is based on two steps. First, data are acquired over large areas in dynamic mode, and locations of interest are flagged based on measured field amplitudes. Second, sensors return to the flagged areas for more in-depth cued interrogation, providing high-quality data for subsequent identification and classification. Flagging based on field amplitude, however, has potential drawbacks: The magnetic field in the EMI regime exhibits a 1/R-6 drop-off with range, and a deep UXO may not produce a strong response while still being potentially hazardous. To address this problem, we propose in this paper an inversion method based on Kalman and extended Kalman filters meant to do the following: 1) work with dynamic data; 2) provide both position and polarizability estimates; and 3) operate in real time (less than 100 ms in our case). Such full characterization of the target, albeit limited to within the 2.7-ms interrogation time window of the dynamic mode associated with the sensors studied here, provides useful information when deciding whether to continue with the cued interrogation. We validate the method for two popular EMI sensors, the second-version Man Portable Vector (MPV-II) and the MetalMapper, operated in very different settings: The MPV-II is used to interrogate a limited region of space atop a single target, whereas the MetalMapper is driven over long lanes along which several targets and clutter items are present.
C1 [Grzegorczyk, Tomasz M.] Delpsi LLC, Newton, MA 02458 USA.
[Barrowes, Benjamin E.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
RP Grzegorczyk, TM (reprint author), Delpsi LLC, Newton, MA 02458 USA.
EM tomasz.grzegorczyk@delpsi.com; Benjamin.E.Barrowes@usace.army.mil
FU Strategic Environmental Research and Development Program
[W912HQ-11-C-0072]
FX This work was supported by the Strategic Environmental Research and
Development Program under Contract W912HQ-11-C-0072.
NR 40
TC 2
Z9 2
U1 0
U2 13
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0196-2892
J9 IEEE T GEOSCI REMOTE
JI IEEE Trans. Geosci. Remote Sensing
PD JUN
PY 2013
VL 51
IS 6
BP 3439
EP 3451
DI 10.1109/TGRS.2012.2222032
PN 1
PG 13
WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote
Sensing; Imaging Science & Photographic Technology
SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science
& Photographic Technology
GA 171PE
UT WOS:000320940600020
ER
PT J
AU Rosati, JD
Dean, RG
Walton, TL
AF Rosati, J. D.
Dean, R. G.
Walton, T. L.
TI The modified Bruun Rule extended for landward transport
SO MARINE GEOLOGY
LA English
DT Article
DE shoreline retreat; sea level rise; overwash; equilibrium beach profile
ID SEA-LEVEL RISE; COASTAL EROSION; BARRIER ISLANDS; BEACH EROSION;
OVERWASH; MODEL; STORMS; SCALE
AB The Bruun Rule (Bruun, 1954, 1962) provides a relationship between sea level rise and shoreline retreat, and has been widely applied by the engineering and scientific communities to interpret shoreline changes and to plan for possible future increases in sea level rise rates. The Bruun Rule assumes that all sand removed from the upper profile is deposited offshore as sea level rises, although overwash during storms and landward Aeolian transport clearly indicate otherwise. Herein, we examine processes associated with sandy beach evolution in response to relative sea level rise and propose a modified form of the Bruun Rule that considers the full range of parsing cross-shore transport, from completely seaward to completely landward depending on the prevailing storm and surge conditions and whether there is a surplus or deficit of sand in the profile with respect to the equilibrium beach profile. A methodology is proposed that more appropriately represents the long-term processes and beach response. However, an improved quantitative understanding of landward transport is required for optimal application of the proposed method. Published by Elsevier B.V.
C1 [Rosati, J. D.] US Army Corps Engineers, Washington, DC 20314 USA.
[Dean, R. G.] Univ Florida, Gainesville, FL 32605 USA.
[Walton, T. L.] Coastal Tech Corp, Tallahassee, FL USA.
RP Rosati, JD (reprint author), US Army Corps Engineers, Washington, DC 20314 USA.
EM Julie.D.Rosati@usace.army.mil
FU USACE's Coastal Inlets Research Program (CIRP)
FX We appreciate suggestions and comments from Mr. Mark Gravens, U.S. Army
Corps of Engineers (USACE), Dr. James Houston, Retired Emeritus, USACE,
two anonymous reviewers and the Editor, who greatly improved the clarity
of the manuscript. This work was conducted with partial funding (JDR)
from the USACE's Coastal Inlets Research Program (CIRP).
NR 62
TC 13
Z9 13
U1 1
U2 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0025-3227
J9 MAR GEOL
JI Mar. Geol.
PD JUN 1
PY 2013
VL 340
BP 71
EP 81
DI 10.1016/j.margeo.2013.04.018
PG 11
WC Geosciences, Multidisciplinary; Oceanography
SC Geology; Oceanography
GA 180OF
UT WOS:000321603800006
ER
PT J
AU Yang, Y
Callahan, JM
Kim, TH
Brown, AS
Everitt, HO
AF Yang, Yang
Callahan, John M.
Kim, Tong-Ho
Brown, April S.
Everitt, Henry O.
TI Ultraviolet Nanoplasmonics: A Demonstration of Surface-Enhanced Raman
Spectroscopy, Fluorescence, and Photodegradation Using Gallium
Nanoparticles
SO NANO LETTERS
LA English
DT Article
DE Ultraviolet; plasmonics; gallium; nanoparticles; surface-enhanced Raman;
surface-enhanced fluorescence
ID SINGLE-MOLECULE DETECTION; UV RESONANCE RAMAN; METAL NANOPARTICLES;
CRYSTAL-VIOLET; ALUMINUM NANOPARTICLES; SCATTERING SERS; EXCITATION;
PHOTOLUMINESCENCE; ELLIPSOMETRY; DYNAMICS
AB Self-assembled arrays of hemispherical gallium nanoparticles deposited by molecular beam epitaxy on a sapphire support are explored as a new type of substrate for ultraviolet plasmonics. Spin-casting a 5 nm film of crystal violet upon these nanoparticles permitted the demonstration of surface-enhanced Raman spectra, fluorescence, and degradation following excitation by a HeCd laser operating at 325 nm. Measured local Raman enhancement factors exceeding 10(7) demonstrate the potential of gallium nanoparticle arrays for plasmonically enhanced ultraviolet detection and remediation.
C1 [Yang, Yang; Everitt, Henry O.] Duke Univ, Dept Phys, Durham, NC 27708 USA.
[Callahan, John M.] AEgis Technol Grp Inc, Huntsville, AL 35806 USA.
[Kim, Tong-Ho; Brown, April S.; Everitt, Henry O.] Duke Univ, Dept Elect & Comp Engn, Durham, NC 27708 USA.
[Everitt, Henry O.] USA, Aviat & Missile RD&E Ctr, Redstone Arsenal, AL 35898 USA.
RP Everitt, HO (reprint author), Duke Univ, Dept Phys, Durham, NC 27708 USA.
RI Everitt, Henry/L-7118-2013
OI Everitt, Henry/0000-0002-8141-3768
FU Army Aviation & Missile Research, Development, and Engineering Center;
Office of Naval Research
FX This work was supported by the Army Aviation & Missile Research,
Development, and Engineering Center and the Office of Naval Research.
The authors thank the early contributions of Ga NP SERS, spin-casting of
CV, and building the spectrometer by P. C. Wu, K. R. Lantz, and J. V.
Foreman, respectively. The authors would like to thank Greg Sun, Dana
Dlott, Maria Losurdo, George Schatz, Fernando Moreno, Francisco
Gonzalez, Pablo Albella, and Juan Marcos Sanz Casado for their
insightful comments.
NR 56
TC 31
Z9 31
U1 7
U2 136
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1530-6984
J9 NANO LETT
JI Nano Lett.
PD JUN
PY 2013
VL 13
IS 6
BP 2837
EP 2841
DI 10.1021/nl401145j
PG 5
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA 165LJ
UT WOS:000320485100085
PM 23659187
ER
PT J
AU West, D
West, BJ
AF West, Damien
West, Bruce J.
TI Physiologic time: A hypothesis
SO PHYSICS OF LIFE REVIEWS
LA English
DT Review
ID UNIVERSAL METABOLIC ALLOMETRY; IRREVERSIBLE-PROCESSES; SCALING LAWS;
STATISTICAL ARTIFACT; RECIPROCAL RELATIONS; ENERGY-METABOLISM; ONTOGENIC
GROWTH; COMPLEX NETWORKS; ENQUIST MODEL; GENERAL-MODEL
AB The scaling of respiratory metabolism with body size in animals is considered by many to be a fundamental law of nature. One apparent consequence of this law is the scaling of physiologic time with body size, implying that physiologic time is separate and distinct from clock time. Physiologic time is manifest in allometry relations for lifespans, cardiac cycles, blood volume circulation, respiratory cycle, along with a number of other physiologic phenomena. Herein we present a theory of physiologic time that explains the allometry relation between time and total body mass averages as entailed by the hypothesis that the fluctuations in the total body mass are described by a scaling probability density. Published by Elsevier B.V.
C1 [West, Damien] Rensselaer Polytech Inst, Dept Phys, Troy, NY 12180 USA.
[West, Bruce J.] US Army Res Off, Informat Sci Directorate, Res Triangle Pk, NC USA.
RP West, BJ (reprint author), US Army Res Off, Informat Sci Directorate, Res Triangle Pk, NC USA.
EM bruce.j.west.civ@mail.mil
RI West, Damien/F-8616-2012; West, Bruce/E-3944-2017
OI West, Damien/0000-0002-4970-3968;
NR 94
TC 20
Z9 20
U1 0
U2 25
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1571-0645
EI 1873-1457
J9 PHYS LIFE REV
JI Phys. Life Rev.
PD JUN
PY 2013
VL 10
IS 2
BP 210
EP 224
DI 10.1016/j.plrev.2013.04.006
PG 15
WC Biology; Biophysics
SC Life Sciences & Biomedicine - Other Topics; Biophysics
GA 179QZ
UT WOS:000321537700019
PM 23659904
ER
PT J
AU Peterson, TC
Heim, RR
Hirsch, R
Kaiser, DP
Brooks, H
Diffenbaugh, NS
Dole, RM
Giovannettone, JP
Guirguis, K
Karl, TR
Katz, RW
Kunkel, K
Lettenmaier, D
McCabe, GJ
Paciorek, CJ
Ryberg, KR
Schubert, S
Silva, VBS
Stewart, BC
Vecchia, AV
Villarini, G
Vose, RS
Walsh, J
Wehner, M
Wolock, D
Wolter, K
Woodhouse, CA
Wuebbles, D
AF Peterson, Thomas C.
Heim, Richard R., Jr.
Hirsch, Robert
Kaiser, Dale P.
Brooks, Harold
Diffenbaugh, Noah S.
Dole, Randall M.
Giovannettone, Jason P.
Guirguis, Kristen
Karl, Thomas R.
Katz, Richard W.
Kunkel, Kenneth
Lettenmaier, Dennis
McCabe, Gregory J.
Paciorek, Christopher J.
Ryberg, Karen R.
Schubert, Siegfried
Silva, Viviane B. S.
Stewart, Brooke C.
Vecchia, Aldo V.
Villarini, Gabriele
Vose, Russell S.
Walsh, John
Wehner, Michael
Wolock, David
Wolter, Klaus
Woodhouse, Connie A.
Wuebbles, Donald
TI MONITORING AND UNDERSTANDING CHANGES IN HEAT WAVES, COLD WAVES, FLOODS,
AND DROUGHTS IN THE UNITED STATES: State of Knowledge
SO BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY
LA English
DT Article
ID SOUTHWESTERN NORTH-AMERICA; SOIL-MOISTURE; CLIMATE-CHANGE; WATER
MANAGEMENT; GREAT-PLAINS; NEW-ENGLAND; DUST-BOWL; US; TEMPERATURE;
STREAMFLOW
AB Weather and climate extremes have been varying and changing on many different time scales. In recent decades, heat waves have generally become more frequent across the United States, while cold waves have been decreasing. While this is in keeping with expectations in a warming climate, it turns out that decadal variations in the number of U.S. heat and cold waves do not correlate well with the observed U.S. warming during the last century. Annual peak flow data reveal that river flooding trends on the century scale do not show uniform changes across the country. While flood magnitudes in the Southwest have been decreasing, flood magnitudes in the Northeast and north-central United States have been increasing. Confounding the analysis of trends in river flooding is multiyear and even multidecadal variability likely caused by both large-scale atmospheric circulation changes and basin-scale memory in the form of soil moisture. Droughts also have long-term trends as well as multiyear and decadal variability. Instrumental data indicate that the Dust Bowl of the 1930s and the drought in the 1950s were the most significant twentieth-century droughts in the United States, while tree ring data indicate that the megadroughts over the twelfth century exceeded anything in the twentieth century in both spatial extent and duration. The state of knowledge of the factors that cause heat waves, cold waves, floods, and drought to change is fairly good with heat waves being the best understood.
C1 [Peterson, Thomas C.; Heim, Richard R., Jr.; Vose, Russell S.] NOAA, Natl Climat Data Ctr, Asheville, NC 28803 USA.
[Hirsch, Robert] US Geol Survey, Reston, VA 22092 USA.
[Kaiser, Dale P.] US DOE, Carbon Dioxide Informat Anal Ctr, Oak Ridge Natl Lab, Oak Ridge, TN USA.
[Brooks, Harold] NOAA, Natl Severe Storms Lab, Norman, OK 73069 USA.
[Diffenbaugh, Noah S.] Stanford Univ, Stanford, CA 94305 USA.
[Dole, Randall M.; Wolter, Klaus] NOAA, Earth Syst Res Lab, Boulder, CO USA.
[Giovannettone, Jason P.] US Army Corp Engineers, Inst Water Resources, Alexandria, VA USA.
[Guirguis, Kristen] Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA.
[Guirguis, Kristen] Univ Corp Atmospher Res, Boulder, CO USA.
[Katz, Richard W.] Natl Ctr Atmospher Res, Boulder, CO 80307 USA.
[Kunkel, Kenneth] Cooperat Inst Climate & Satellites, Asheville, NC USA.
[Lettenmaier, Dennis] Univ Washington, Seattle, WA 98195 USA.
[McCabe, Gregory J.; Wolock, David] USGS, Lawrence, KS USA.
[Paciorek, Christopher J.] Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA.
[Ryberg, Karen R.; Vecchia, Aldo V.] US Geol Survey, Bismarck, ND USA.
[Schubert, Siegfried] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA.
[Silva, Viviane B. S.] NOAA, Climate Serv Div, NWS, OCWWS, Silver Spring, MD USA.
[Stewart, Brooke C.] STG, Asheville, NC USA.
[Villarini, Gabriele] Univ Iowa, IIHR Hydrosci & Engn, Iowa City, IA USA.
[Walsh, John] Univ Alaska Fairbanks, Fairbanks, AK USA.
[Wehner, Michael] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA.
[Woodhouse, Connie A.] Univ Arizona, Tucson, AZ USA.
[Wuebbles, Donald] Univ Illinois, Urbana, IL USA.
RP Peterson, TC (reprint author), NOAA, Natl Climat Data Ctr, 151 Patton Ave, Asheville, NC 28803 USA.
EM thomas.c.peterson@noaa.gov
RI lettenmaier, dennis/F-8780-2011; Diffenbaugh, Noah/I-5920-2014; Kunkel,
Kenneth/C-7280-2015; Wolter, Klaus/D-5988-2015; Katz,
Richard/K-4133-2012; Ryberg, Karen/E-1871-2016; Villarini,
Gabriele/F-8069-2016;
OI lettenmaier, dennis/0000-0003-3317-1327; Diffenbaugh,
Noah/0000-0002-8856-4964; Kunkel, Kenneth/0000-0001-6667-7047; Katz,
Richard/0000-0002-0267-8953; Ryberg, Karen/0000-0002-9834-2046;
Villarini, Gabriele/0000-0001-9566-2370; Hirsch,
Robert/0000-0002-4534-075X
NR 95
TC 84
Z9 85
U1 10
U2 132
PU AMER METEOROLOGICAL SOC
PI BOSTON
PA 45 BEACON ST, BOSTON, MA 02108-3693 USA
SN 0003-0007
EI 1520-0477
J9 B AM METEOROL SOC
JI Bull. Amer. Meteorol. Soc.
PD JUN
PY 2013
VL 94
IS 6
BP 821
EP 834
DI 10.1175/BAMS-D-12-00066.1
PG 14
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA 175TK
UT WOS:000321256100005
ER
PT J
AU Goren, AD
Prins, RD
Dauer, LT
Quinn, B
Al-Najjar, A
Faber, RD
Patchell, G
Branets, I
Colosi, DC
AF Goren, A. D.
Prins, R. D.
Dauer, L. T.
Quinn, B.
Al-Najjar, A.
Faber, R. D.
Patchell, G.
Branets, I.
Colosi, D. C.
TI Effect of leaded glasses and thyroid shielding on cone beam CT radiation
dose in an adult female phantom
SO DENTOMAXILLOFACIAL RADIOLOGY
LA English
DT Article
DE Leaded glasses; thyroid shielding; CBCT dosimetry; dose reduction; eye
lens dose
ID COMPUTED-TOMOGRAPHY; DENTAL RADIOGRAPHY; REDUCTION; CANCER; BREAST; HEAD
AB Objectives: This study aims to demonstrate the effectiveness of leaded glasses in reducing the lens of eye dose and of lead thyroid collars in reducing the dose to the thyroid gland of an adult female from dental cone beam CT (CBCT). The effect of collimation on the radiation dose in head organs is also examined.
Methods: Dose measurements were conducted by placing optically stimulated luminescent dosemeters in an anthropomorphic female phantom. Eye lens dose was measured by placing a dosemeter on the anterior surface of the phantom eye location. All exposures were performed on one commercially available dental CBCT machine, using selected collimation and exposure techniques. Each scan technique was performed without any lead shielding and then repeated with lead shielding in place. To calculate the percent reduction from lead shielding, the dose measured with lead shielding was divided by the dose measured without lead shielding. The percent reduction from collimation was calculated by comparing the dose measured with collimation to the dose measured without collimation.
Results: The dose to the internal eye for one of the scans without leaded glasses or thyroid shield was 0.450 cGy and with glasses and thyroid shield was 0.116 cGy (a 74% reduction). The reduction to the lens of the eye was from 0.396 cGy to 0.153 cGy (a 61% reduction). Without glasses or thyroid shield, the thyroid dose was 0.158 cGy; and when both glasses and shield were used, the thyroid dose was reduced to 0.091 cGy (a 42% reduction).
Conclusions: Collimation alone reduced the dose to the brain by up to 91%, with a similar reduction in other organs. Based on these data, leaded glasses, thyroid collars and collimation minimize the dose to organs outside the field of view.
C1 [Goren, A. D.; Branets, I.] NYU, Coll Dent, Dept Cariol & Comprehens Care, New York, NY 10010 USA.
[Goren, A. D.; Al-Najjar, A.; Faber, R. D.; Patchell, G.; Colosi, D. C.] SUNY Stony Brook, Sch Dent Med, Dept Prosthodont & Digital Technol, Stony Brook, NY 11794 USA.
[Prins, R. D.] US Army, Def Threat Reduct Agcy, Ft Belvoir, VA USA.
[Dauer, L. T.; Quinn, B.] Mem Sloan Kettering Canc Ctr, Dept Med Phys & Radiol, New York, NY 10021 USA.
[Al-Najjar, A.; Faber, R. D.] Stony Brook Sch Dent Med, Dept Orthodont, Stony Brook, NY USA.
RP Goren, AD (reprint author), NYU, Coll Dent, New York, NY 10010 USA.
EM sag2172@aol.com
OI Dauer, Lawrence/0000-0002-5629-8462
NR 36
TC 10
Z9 10
U1 0
U2 7
PU BRITISH INST RADIOLOGY
PI LONDON
PA 36 PORTLAND PLACE, LONDON W1N 4AT, ENGLAND
SN 0250-832X
J9 DENTOMAXILLOFAC RAD
JI Dentomaxillofac. Radiol.
PD JUN
PY 2013
VL 42
IS 6
AR 20120260
DI 10.1259/dmfr.20120260
PG 7
WC Dentistry, Oral Surgery & Medicine; Radiology, Nuclear Medicine &
Medical Imaging
SC Dentistry, Oral Surgery & Medicine; Radiology, Nuclear Medicine &
Medical Imaging
GA 168BC
UT WOS:000320679700004
PM 23412460
ER
PT J
AU McDonald, RMS
AF McDonald, Robert M. S.
TI The Papers of Thomas Jefferson, Retirement Series, vol 6, 11 March to 27
November 1813
SO JOURNAL OF AMERICAN HISTORY
LA English
DT Book Review
C1 [McDonald, Robert M. S.] US Mil Acad, West Point, NY 10996 USA.
RP McDonald, RMS (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU ORGANIZATION AMER HISTORIANS
PI BLOOMINGTON
PA 112 N BRYAN ST, BLOOMINGTON, IN 47408 USA
SN 0021-8723
J9 J AM HIST
JI J. Am. Hist.
PD JUN
PY 2013
VL 100
IS 1
BP 190
EP 191
DI 10.1093/jahist/jat028
PG 2
WC History
SC History
GA 160OJ
UT WOS:000320128700030
ER
PT J
AU Williams, BR
Hulet, MS
Brozena, A
Miles, RW
Tevault, DE
AF Williams, Barry R.
Hulet, Melissa S.
Brozena, Ann
Miles, Ronald W., Jr.
Tevault, David E.
TI Vapor Pressure of 2-Dialkyl Aminoethanethiols
SO JOURNAL OF CHEMICAL AND ENGINEERING DATA
LA English
DT Article
AB The vapor pressures of three 2-dialkyl aminoethanethiol compounds, 2-dimethyl aminoethanethiol (DMA), 2-diethyl aminoethanethiol (DEA), and 2-diisopropyl aminoethanethiol (DIA), have been determined using complementary methods that enable data collection in the ambient and high temperature ranges using vapor saturation and differential scanning calorimetry, respectively. Previously published vapor pressure data for these materials are sparse, conflicting, and limited in the pressure ranges covered. This work greatly expands the experimental range and, owing to the good agreement obtained using complementary methods, significantly enhances confidence in the accuracy of the measured data. In addition to the observed data, this report includes derived properties, that is, temperature-dependent volatility and heats of vaporization.
C1 [Williams, Barry R.; Hulet, Melissa S.] Sci Applicat Int Corp, Gunpowder, MD 21010 USA.
[Brozena, Ann; Miles, Ronald W., Jr.; Tevault, David E.] US Army Edgewood Chem Biol Ctr, Res & Technol Directorate, RDCB DR, Aberdeen Proving Ground, MD 21010 USA.
RP Tevault, DE (reprint author), US Army Edgewood Chem Biol Ctr, Res & Technol Directorate, RDCB DR, Aberdeen Proving Ground, MD 21010 USA.
EM david.e.tevault.ctr@mail.mil
NR 28
TC 3
Z9 3
U1 0
U2 5
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-9568
J9 J CHEM ENG DATA
JI J. Chem. Eng. Data
PD JUN
PY 2013
VL 58
IS 6
BP 1679
EP 1684
DI 10.1021/je400136y
PG 6
WC Thermodynamics; Chemistry, Multidisciplinary; Engineering, Chemical
SC Thermodynamics; Chemistry; Engineering
GA 167OK
UT WOS:000320641100034
ER
PT J
AU Wilson, WR
Magnussen, RA
Irribarra, LA
Taylor, DC
AF Wilson, William R.
Magnussen, Robert A.
Irribarra, Luis A.
Taylor, Dean C.
TI Variability of the capsular anatomy in the rotator interval region of
the shoulder
SO JOURNAL OF SHOULDER AND ELBOW SURGERY
LA English
DT Article
DE Anatomy; shoulder; rotator interval; anatomic variability; arthroscopy
ID GLENOHUMERAL LIGAMENTS; INSTABILITY; COMPLEX; ANTERIOR; CLOSURE;
PATHOLOGY; HISTOLOGY
AB Purpose: Anterior shoulder anatomy is as complex and variable as its descriptive terminology. A detailed understanding of normal anatomic variability is critical to accurate performance, description, and evaluation of the procedures involving the rotator interval. We aimed to define, arthroscopically, the anatomic variability in the rotator interval region of the shoulder and to compare these results to the findings of previous cadaveric studies.
Methods: The rotator interval anatomy of 104 consecutive patients was classified according to the system of DePalma. Anatomic variability was evaluated and compared with findings of previous authors.
Results: Shoulders were classified as follows: 59% type 1 (rotator interval capsular opening [RICO] superolateral to the MGHL); 1% type 2 (RICO inferomedial to the middle glenohumeral ligament [MGHL]); 22% type 3 (2 RICOs: 1 above and 1 below the MGHL); 9% type 4 (large RICO, no MGHL); 0% type 5 (the MGHL is manifested as 2 small RICOs); 7% Type 6 (no RICO); and 3% distinct Buford complex. We found a larger percentage of type 1 shoulders and a lower percentage of type 3 shoulders relative to prior open cadaveric dissections. No difference in the distribution of DePalma types was noted based surgical indication.
Conclusions: The anatomy of the rotator interval as viewed arthroscopically is complex and variable. While DePalma types 1 and 3 are most commonly encountered, other anatomic variants are frequent and should be considered when assessing and manipulating structures in region of the rotator interval and anterior shoulder.
Level of evidence: Basic Science, Anatomy Study, In-Vivo. (C) 2013 Journal of Shoulder and Elbow Surgery Board of Trustees.
C1 [Wilson, William R.] Eisenhower Army Med Ctr, Orthopaed Surg Serv, Ft Gordon, GA USA.
[Magnussen, Robert A.] Ohio State Univ, Dept Orthopaed, OSU Sports Med Sports Hlth & Performance Inst, Columbus, OH 43210 USA.
[Irribarra, Luis A.] Pontificia Univ Catolica Chile, Dept Orthopaed, Santiago, Chile.
[Taylor, Dean C.] Duke Univ, Med Ctr, Durham, NC 27710 USA.
RP Taylor, DC (reprint author), Duke Univ, Med Ctr, Box 3615, Durham, NC 27710 USA.
EM dean.taylor@duke.edu
RI Magnussen, Robert/B-6177-2012
NR 18
TC 2
Z9 2
U1 0
U2 7
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1058-2746
J9 J SHOULDER ELB SURG
JI J. Shoulder Elbow Surg.
PD JUN
PY 2013
VL 22
IS 6
BP 856
EP 861
DI 10.1016/j.jse.2012.08.024
PG 6
WC Orthopedics; Sport Sciences; Surgery
SC Orthopedics; Sport Sciences; Surgery
GA 172IP
UT WOS:000320995800027
PM 23177168
ER
PT J
AU Fifer, AM
AF Fifer, Angela M.
TI Introduction to Sport Psychology Consulting: Working With Coaches and
Teams.
SO SPORT PSYCHOLOGIST
LA English
DT Book Review
C1 [Fifer, Angela M.] US Mil Acad, Ctr Enhanced Performance, West Point, NY 10996 USA.
RP Fifer, AM (reprint author), US Mil Acad, Ctr Enhanced Performance, West Point, NY 10996 USA.
NR 1
TC 0
Z9 0
U1 1
U2 6
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 0888-4781
J9 SPORT PSYCHOL
JI Sport Psychol.
PD JUN
PY 2013
VL 27
IS 2
BP 212
EP 212
PG 1
WC Hospitality, Leisure, Sport & Tourism; Psychology, Applied; Psychology;
Sport Sciences
SC Social Sciences - Other Topics; Psychology; Sport Sciences
GA 174MD
UT WOS:000321158800010
ER
PT J
AU Drake, B
Paterson, R
Cushing, T
Tabin, G
Butler, F
AF Drake, Brandy
Paterson, Ryan
Cushing, Tracy
Tabin, Geoffrey
Butler, Frank
TI In Response to WMS Practice Guidelines for Eye Injuries and Illnesses
Reply
SO WILDERNESS & ENVIRONMENTAL MEDICINE
LA English
DT Letter
C1 [Drake, Brandy; Paterson, Ryan; Cushing, Tracy] Univ Colorado, Sch Med, Denver Hlth Med Ctr, Denver, CO 80202 USA.
[Tabin, Geoffrey] Univ Utah, Sch Med, Salt Lake City, UT USA.
[Butler, Frank] USA, Inst Surg Res, Comm Tact Combat Casualty Care, Def Board, Ft Sam Houston, TX 78234 USA.
RP Drake, B (reprint author), Univ Colorado, Sch Med, Denver Hlth Med Ctr, Denver, CO 80202 USA.
NR 5
TC 0
Z9 0
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1080-6032
J9 WILD ENVIRON MED
JI Wildern. Environ. Med.
PD SUM
PY 2013
VL 24
IS 2
BP 182
EP 183
PG 2
WC Public, Environmental & Occupational Health; Sport Sciences
SC Public, Environmental & Occupational Health; Sport Sciences
GA 162UB
UT WOS:000320290400025
PM 23578706
ER
PT J
AU Birchak, JC
Rochette, LM
Smith, GA
AF Birchak, John C.
Rochette, Lynne M.
Smith, Gary A.
TI Softball injuries treated in US EDs, 1994 to 2010
SO AMERICAN JOURNAL OF EMERGENCY MEDICINE
LA English
DT Article
ID HIGH-SCHOOL BASEBALL; UNITED-STATES; EMERGENCY-DEPARTMENTS; SPORTS;
PREVENTION; EPIDEMIOLOGY; SURVEILLANCE; PATTERNS
AB Background: Softball is a popular participant sport in the United States. This study investigated the epidemiology of softball injuries with comparisons between children and adults.
Methods: Data from the National Electronic Injury Surveillance System for patients 7 years and older treated in an emergency department (ED) for a softball injury from 1994 through 2010 were analyzed.
Results: An estimated 2107823 (95% confidence interval [CI], 1736417-2479229) patients were treated in US EDs for a softball injury during the 17-year study period. The annual number of injuries decreased by 23.0% from 1994 to 2010 (P < .001); however, during the last 6 years of the study, injuries increased by 11.7% (P = .008). The annual rate of softball injuries increased significantly during the study period (P = .035). The most commonly injured body regions were the hand/wrist (22.2%) and face (19.3%). Being hit by a ball was the most common mechanism of injury (52.4%) and accounted for most of face (89.6%) and head (75.7%) injuries. Injuries associated with running (relative risk, 2.36; 95% CI, 1.97-2.82) and diving for a ball (relative risk, 4.61; 95% CI, 3.50-6.09) were more likely to occur among adult than pediatric patients.
Conclusions: To our knowledge, this is the first study to investigate softball injuries using a nationally representative sample. Softball is a common source of injury among children and adults. Increased efforts are needed to promote safety measures, such as face guards, mouth guards, safety softballs, and break-away bases, to decrease these injuries. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Birchak, John C.; Rochette, Lynne M.; Smith, Gary A.] Nationwide Childrens Hosp, Ctr Injury Res & Policy, Res Inst, Columbus, OH 43205 USA.
[Birchak, John C.; Smith, Gary A.] Ohio State Univ, Coll Med, Columbus, OH 43210 USA.
[Rochette, Lynne M.] US Army Res Inst Behav & Social Sci, Ft Belvoir, VA USA.
[Smith, Gary A.] Child Injury Prevent Alliance, Columbus, OH USA.
RP Smith, GA (reprint author), Nationwide Childrens Hosp, Ctr Injury Res & Policy, Res Inst, Columbus, OH 43205 USA.
EM gary.smith@nationwidechildrens.org
FU Medical Student Research Scholarship Fund of The Ohio State University
College of Medicine
FX The authors have no conflicts of interest or financial disclosures
relevant to this article to declare. John C. Birchak received a student
research scholarship from the Medical Student Research Scholarship Fund
of The Ohio State University College of Medicine while he worked on this
study.; We thank Natalie McIlvain for her helpful comments and
suggestions. The authors also gratefully acknowledge support from the
Medical Student Research Scholarship Fund of The Ohio State University
College of Medicine, which provided a student research stipend for
author JCB, while he worked on this study. Interpretations and
conclusions expressed in this article do not necessarily represent those
of the funding institution.
NR 32
TC 4
Z9 4
U1 1
U2 10
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0735-6757
J9 AM J EMERG MED
JI Am. J. Emerg. Med.
PD JUN
PY 2013
VL 31
IS 6
BP 900
EP 905
DI 10.1016/j.ajem.2013.02.039
PG 6
WC Emergency Medicine
SC Emergency Medicine
GA 167SO
UT WOS:000320655100002
PM 23602754
ER
PT J
AU Bryson, AJ
Woodley, CM
Karls, RK
Hall, KD
Weiland, MA
Deng, ZD
Carlson, TJ
Eppard, MB
AF Bryson, Amanda J.
Woodley, Christa M.
Karls, Rhonda K.
Hall, Kathleen D.
Weiland, Mark A.
Deng, Z. Daniel
Carlson, Thomas J.
Eppard, M. Brad
TI Comparison of 180-degree and 90-degree needle rotation to reduce wound
size in PIT-injected juvenile Chinook salmon
SO FISHERIES RESEARCH
LA English
DT Article
DE Fish telemetry; Passive integrated transponder; Acoustic telemetry;
Wound healing; Injection techniques
ID INTEGRATED TRANSPONDER TAGS; RETENTION; MORTALITY; SURVIVAL;
IMPLANTATION; PERFORMANCE; BEVEL
AB Most telemetry studies require the implantation or attachment of passive transponders or active transmitters to monitor and assess fish stocks and conservation to gain an understanding of fish physiology and behavior. As new telemetry technologies become available, it is imperative to study the effect of the transmitter or implantation technique on species of interest. In this study, we investigated the effects of needle axial or bevel rotation (0-, 90-, 180-degree) on wound extent and healing, and tag loss in juvenile Chinook salmon injected with an 8-gauge needle, which is required for implantation of the injectable juvenile Salmon Acoustic Telemetry Systems acoustic transmitter and some passive integrated transponders (PITs). Although the wounds were not closed after injection (e.g., with sutures or glue), there were no mortalities, dropped tags, or indications of fungus, ulceration, or redness around the wound. No axial rotation (0-degrees) resulted in the PIT tag frequently misloading or falling out before injection. On Day 0 and post-implantation Day 7, the 90-degree bevel rotation produced a significantly smaller wound extent than the 180-degree bevel rotation. Given the wound extent compared to size of fish, we recommend researchers should consider a 90-degree rotation over the 180-degree rotation when injecting transmitters. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Bryson, Amanda J.; Woodley, Christa M.; Karls, Rhonda K.; Hall, Kathleen D.; Carlson, Thomas J.] Pacific NW Natl Lab, Sequim, WA 98382 USA.
[Weiland, Mark A.] Pacific NW Natl Lab, North Bonneville, WA 98369 USA.
[Deng, Z. Daniel] Pacific NW Natl Lab, Richland, WA 99354 USA.
[Eppard, M. Brad] USA, Corps Engineers, Portland, OR 97208 USA.
RP Woodley, CM (reprint author), Pacific NW Natl Lab, 1529W Sequim Bay Rd, Sequim, WA 98382 USA.
EM christa.woodley@pnnl.gov
RI Deng, Daniel/A-9536-2011
OI Deng, Daniel/0000-0002-8300-8766
FU United States Army Corps of Engineers
FX This research was funded by United States Army Corps of Engineers as
part of the bio-effects research for the JSATS injectable acoustic
transmitter development project. We thank PNNL staff Tim Linley, Shon
Zimmerman, Katie Wagner, Eric Fischer, Ron Kaufmann, John Vavrinec,
Michele Halvorsen, Lara Aston, and Jayson Martinez for technical and
graphical support. In addition, we thank Susan Ennor and Amoret Bunn for
the editorial review and comments.
NR 18
TC 2
Z9 2
U1 0
U2 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-7836
J9 FISH RES
JI Fish Res.
PD JUN
PY 2013
VL 143
BP 201
EP 204
DI 10.1016/j.fishres.2013.02.011
PG 4
WC Fisheries
SC Fisheries
GA 151WS
UT WOS:000319491700022
ER
PT J
AU Darlington, DN
Gonzales, MD
AF Darlington, Daniel N.
Gonzales, Mary D.
TI HPLC DETERMINATION OF VALPROIC ACID IN PLASMA BY CONJUGATION TO A
HYDRAZIDE
SO JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
LA English
DT Article
DE DCCH; fluorescence; HPLC; plasma; valproic acid
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; HEMORRHAGIC-SHOCK; RODENT MODEL;
DERIVATIZATION; RESUSCITATION; CARBODIIMIDE
AB We developed a method to measure plasma levels of valproic acid (VA) using pre-column conjugation of VA to the fluorescent probe, 7-diethylaminocoumarin-3-carboxylic acid, hydrazide (DCCH). Swine plasma was spiked with varying concentration of VA. 2-phenylbutyric acid (2PB) was used as an internal standard. VA and 2PB were extracted from plasma (10 mu L) using NaCl, MeCN, and ethyl acetate. Extraction efficiency ranged from 85-92%. After conjugation to DCCH, the VA and 2BP, conjugates were easily separated on reverse phase HPLC using a 55-70% MeCN/H2O gradient. Standard curves were generated from the absorbance (=430nm) and fluorescence ((ex)=415nm, (em)=465nm) that described an exponential curve y-a(1-b(x)) with correlation coefficients >0.97. The inter-assay variation measured over 12 days was <3% for the high pool (5mg/mL) and 10% for the low pool (0.5mg/mL). The intra-assay variation measured over 5 replicates/day was <3.5% for both the high and low pools. The calculated standard curves predicted the actual values of the standards. This assay can be used to measure plasma concentrations of VA in patients or laboratory animals being treated with VA.
C1 [Darlington, Daniel N.; Gonzales, Mary D.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Darlington, DN (reprint author), US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
EM daniel.darlington@us.army.mil
FU US Army Medical Research Material Command
FX This study has been conducted in compliance with the Animal Welfare Act,
the implementing Animal Welfare Regulations, and in accordance with the
principles of the Guide for the Care and Use of Laboratory Animals. This
project was funded by US Army Medical Research Material Command. We
would like to thank the expert technical help of Kristi Lemke for
getting the project started.
NR 17
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U1 0
U2 6
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1082-6076
J9 J LIQ CHROMATOGR R T
JI J. Liq. Chromatogr. Relat. Technol.
PD JUN 1
PY 2013
VL 36
IS 16
BP 2209
EP 2219
DI 10.1080/10826076.2012.717059
PG 11
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA 171GG
UT WOS:000320912600001
ER
PT J
AU Kochanek, PM
Dixon, CE
Shellington, DK
Shin, SS
Bayir, H
Jackson, EK
Kagan, VE
Yan, HQ
Swauger, PV
Parks, SA
Ritzel, DV
Bauman, R
Clark, RSB
Garman, RH
Bandak, F
Ling, G
Jenkins, LW
AF Kochanek, Patrick M.
Dixon, C. Edward
Shellington, David K.
Shin, Samuel S.
Bayir, Huelya
Jackson, Edwin K.
Kagan, Valerian E.
Yan, Hong Q.
Swauger, Peter V.
Parks, Steven A.
Ritzel, David V.
Bauman, Richard
Clark, Robert S. B.
Garman, Robert H.
Bandak, Faris
Ling, Geoffrey
Jenkins, Larry W.
TI Screening of Biochemical and Molecular Mechanisms of Secondary Injury
and Repair in the Brain after Experimental Blast-Induced Traumatic Brain
Injury in Rats
SO JOURNAL OF NEUROTRAUMA
LA English
DT Article
DE adenosine; antioxidant; ascorbate; ATP; axonal injury; chemokine; combat
casualty care; cyclic AMP; cytokine; gene array; glutathione; improvised
explosive device; lipid peroxidation; multiplex; post-traumatic stress
disorder; purine
ID POSTTRAUMATIC-STRESS-DISORDER; HUMAN CEREBROSPINAL-FLUID;
PROTEIN-KINASE-II; OXIDATIVE STRESS; EXPLOSIVE BLAST; GENE-EXPRESSION;
INDUCED NEUROTRAUMA; MILITARY PERSONNEL; MODEL; CELLS
AB Explosive blast-induced traumatic brain injury (TBI) is the signature insult in modern combat casualty care and has been linked to post-traumatic stress disorder, memory loss, and chronic traumatic encephalopathy. In this article we report on blast-induced mild TBI (mTBI) characterized by fiber-tract degeneration and axonal injury revealed by cupric silver staining in adult male rats after head-only exposure to 35 psi in a helium-driven shock tube with head restraint. We now explore pathways of secondary injury and repair using biochemical/molecular strategies. Injury produced similar to 25% mortality from apnea. Shams received identical anesthesia exposure. Rats were sacrificed at 2 or 24 h, and brain was sampled in the hippocampus and prefrontal cortex. Hippocampal samples were used to assess gene array (RatRef-12 Expression BeadChip; Illumina, Inc., San Diego, CA) and oxidative stress (OS; ascorbate, glutathione, low-molecular-weight thiols [LMWT], protein thiols, and 4-hydroxynonenal [HNE]). Cortical samples were used to assess neuroinflammation (cytokines, chemokines, and growth factors; Luminex Corporation, Austin, TX) and purines (adenosine triphosphate [ATP], adenosine diphosphate, adenosine, inosine, 2'-AMP [adenosine monophosphate], and 5'-AMP). Gene array revealed marked increases in astrocyte and neuroinflammatory markers at 24 h (glial fibrillary acidic protein, vimentin, and complement component 1) with expression patterns bioinformatically consistent with those noted in Alzheimer's disease and long-term potentiation. Ascorbate, LMWT, and protein thiols were reduced at 2 and 24 h; by 24 h, HNE was increased. At 2 h, multiple cytokines and chemokines (interleukin [IL]-1 alpha, IL-6, IL-10, and macrophage inflammatory protein 1 alpha [MIP-1 alpha]) were increased; by 24 h, only MIP-1 alpha remained elevated. ATP was not depleted, and adenosine correlated with 2'-cyclic AMP (cAMP), and not 5'-cAMP. Our data reveal (1) gene-array alterations similar to disorders of memory processing and a marked astrocyte response, (2) OS, (3) neuroinflammation with a sustained chemokine response, and (4) adenosine production despite lack of energy failure-possibly resulting from metabolism of 2'-3'-cAMP. A robust biochemical/molecular response occurs after blast-induced mTBI, with the body protected from blast and the head constrained to limit motion.
C1 [Kochanek, Patrick M.; Dixon, C. Edward; Shin, Samuel S.; Bayir, Huelya; Yan, Hong Q.; Clark, Robert S. B.; Jenkins, Larry W.] Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Pittsburgh, PA 15260 USA.
[Kochanek, Patrick M.; Bayir, Huelya; Clark, Robert S. B.] Univ Pittsburgh, Sch Med, Dept Crit Care Med, Pittsburgh, PA 15260 USA.
[Dixon, C. Edward; Shin, Samuel S.; Yan, Hong Q.] Univ Pittsburgh, Sch Med, Dept Neurol Surg, Pittsburgh, PA 15260 USA.
[Garman, Robert H.] Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA 15260 USA.
[Jackson, Edwin K.] Univ Pittsburgh, Sch Med, Dept Med Pharmacol, Pittsburgh, PA 15260 USA.
[Bayir, Huelya; Kagan, Valerian E.] Univ Pittsburgh, Sch Med, Dept Environm & Occupat Hlth, Pittsburgh, PA 15260 USA.
[Bayir, Huelya; Kagan, Valerian E.] Univ Pittsburgh, Sch Med, Pittsburgh Ctr Free Radical & Antioxidant Hlth, Pittsburgh, PA 15260 USA.
[Shellington, David K.] Univ Calif San Diego, Dept Pediat, San Diego, CA 92103 USA.
[Swauger, Peter V.; Parks, Steven A.] ORA Inc, Fredericksburg, VA USA.
[Bauman, Richard] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Ritzel, David V.] Dyn FX Consulting Ltd, Amherstburg, ON, Canada.
[Bandak, Faris; Ling, Geoffrey] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Neurol, Bethesda, MD 20814 USA.
[Bandak, Faris] Integrated Serv Grp Inc, Potomac, MD USA.
RP Kochanek, PM (reprint author), Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 5th Ave, Pittsburgh, PA 15260 USA.
EM kochanekpm@ccm.upmc.edu
RI Kochanek, Patrick/D-2371-2015;
OI Kochanek, Patrick/0000-0002-2627-913X; Shellington,
David/0000-0001-6708-6978
FU DARPA PREVENT [N660001-10C2124]
FX This work was supported by DARPA PREVENT (N660001-10C2124). The authors
thank Keri Janesko-Feldman and Jeremy Henchir for their technical
support. The authors thank Marci Provins and Fran Mistrick for their
help with manuscript preparation. Microarray data were generated by the
Genomics Core Laboratory, University of Pittsburgh, and statistical
analyses were performed by the GPCL-Bioinformatics Analysis Core
(GPCL-BAC), University of Pittsburgh. The authors thank Dr. James
Lyons-Weiler for his valuable assistance. The views, opinions, and/or
findings contained in this article are those of the authors and should
not be interpreted as representing the official views or policies either
expressed or implied of DARPA or the DoD. This work has been approved
for public release, distribution unlimited.
NR 63
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U1 1
U2 22
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN
PY 2013
VL 30
IS 11
BP 920
EP 937
DI 10.1089/neu.2013.2862
PG 18
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA 166WD
UT WOS:000320589300003
PM 23496248
ER
PT J
AU Daddis, GA
AF Daddis, Gregory A.
TI "A Better War?'-The View from the Nixon White House
SO JOURNAL OF STRATEGIC STUDIES
LA English
DT Article
DE Vietnam War; Civil-Military Relations; Strategy; Richard Nixon;
Creighton Abrams
AB This article examines the relationship between the White House and the US Military Assistance Command, Vietnam (MACV) during President Richard M. Nixon's administration. It argues that dysfunctional civil-military relations between 1969 and 1972 undermined the implementation of a sound military strategy during the United States' withdrawal from South Vietnam as Nixon attempted to achieve peace with honor' during the Vietnam War's final campaigns. By 1972, the relationship between the White House and MACV headquarters had reached the nadir of civil-military relations during the Southeast Asian conflict and had served to undercut the United States' ability to effectively disengage from a long and bitterly contested war.
C1 US Mil Acad, Dept Hist, West Point, NY 10996 USA.
RP Daddis, GA (reprint author), US Mil Acad, Dept Hist, West Point, NY 10996 USA.
NR 84
TC 2
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U1 1
U2 6
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0140-2390
J9 J STRATEGIC STUD
JI J. Strateg. Stud.
PD JUN 1
PY 2013
VL 36
IS 3
BP 357
EP 384
DI 10.1080/01402390.2012.688173
PG 28
WC International Relations; Political Science
SC International Relations; Government & Law
GA 159BR
UT WOS:000320019500003
ER
PT J
AU Manuel, KL
Kirk, JP
Barwick, DH
Bowen, TW
AF Manuel, Kenneth L.
Kirk, James P.
Barwick, D. Hugh
Bowen, Tommy W.
TI Hydrilla Management in Piedmont Reservoirs Using Herbicides and Triploid
Grass Carp: A Case Study
SO NORTH AMERICAN JOURNAL OF FISHERIES MANAGEMENT
LA English
DT Article
ID SANTEE-COOPER RESERVOIRS; SOUTH-CAROLINA; CTENOPHARYNGODON-IDELLA;
VEGETATION; MOVEMENTS; IMPACTS; TEXAS; RIVER; LAKE
AB We developed a three-step management strategy for hydrilla Hydrilla verticillata in five Piedmont reservoirs operated by Duke Energy Corporation. This strategy involves (1) early detection of hydrilla, (2) use of registered herbicides for plant suppression along with stocking 20 triploid Grass Carp Ctenopharyngodon idella per surface acre of infestation, and (3) maintenance stocking of triploid Grass Carp to prevent hydrilla regrowth from tubers. Following this strategy, hydrilla in the water column was eliminated within one calendar year after Grass Carp introduction in four out of five reservoirs. This suggests that integrating herbicide applications with stocking Grass Carp largely eliminates the multiyear lag effect normally associated with using Grass Carp alone. A maintenance density of at least one triploid Grass Carp per eight surface acres of the reservoir prevented hydrilla regrowth except for a brief and minor reinfestation in one of five study reservoirs. This management approach proved successful when hydrilla coverage was as little as 1-3% of the reservoir's surface area. Detecting and controlling hydrilla early during the infestation should reduce the cost of management and perhaps minimize some adverse effects associated with the introduction and use of triploid Grass Carp. Received November 14, 2012; accepted January 15, 2013
C1 [Manuel, Kenneth L.; Barwick, D. Hugh; Bowen, Tommy W.] Duke Energy Corp, Water Strategy Hydro Licensing & Lake Serv, Environm Ctr MG03A3, Huntersville, NC 28078 USA.
[Kirk, James P.] Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
RP Kirk, JP (reprint author), Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM james.p.kirk@usace.army.mil
FU Aquatic Plant Control Research Program
FX We thank Duke Energy Corporation mosquito control crews for their
diligence in locating hydrilla infestations. We also acknowledge the
contributions of K. J. Killgore, W.T. Slack, and A. Harrison-Lewis as
well as two reviewers in editing and improving this article. The support
of the Aquatic Plant Control Research Program is also appreciated.
NR 36
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U1 5
U2 31
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 0275-5947
J9 N AM J FISH MANAGE
JI North Am. J. Fish Manage.
PD JUN 1
PY 2013
VL 33
IS 3
BP 488
EP 492
DI 10.1080/02755947.2013.768570
PG 5
WC Fisheries
SC Fisheries
GA 159CI
UT WOS:000320021200004
ER
PT J
AU Eismann, M
Perconti, P
AF Eismann, Michael
Perconti, Philip
TI Infrared Systems
SO OPTICAL ENGINEERING
LA English
DT Editorial Material
C1 [Eismann, Michael] USAF, Res Lab, Sensors Directorate, Wright Patterson AFB, OH 45433 USA.
[Perconti, Philip] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Eismann, M (reprint author), USAF, Res Lab, Sensors Directorate, Wright Patterson AFB, OH 45433 USA.
EM michael.eismann@wpafb.af.mil; philip.perconti.civ@mail.mil
NR 0
TC 0
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U1 0
U2 4
PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA
SN 0091-3286
J9 OPT ENG
JI Opt. Eng.
PD JUN
PY 2013
VL 52
IS 6
AR 061301
PG 2
WC Optics
SC Optics
GA 151EV
UT WOS:000319444400001
ER
PT J
AU Lilley, S
Vizgaitis, J
Everett, J
Spinazzola, R
AF Lilley, Scott
Vizgaitis, Jay
Everett, Jonathan
Spinazzola, Robert
TI Multifield of view see-spot optics
SO OPTICAL ENGINEERING
LA English
DT Article
DE short-wave; mid-wave; broad band; infrared; optics; catadioptric;
see-spot
AB The increasing availability of sensors that can image in the 1 to 5 mu m region has allowed for systems to be developed that utilize the full spectrum. Current mid-wave infrared (MWIR) systems have typically only imaged in the 3 to 5 mu m region, but the new detectors allow imaging in the short-wave infrared (SWIR) and MWIR bands on the same image plane. Night Vision and Electronic Sensors Directorate (NVESD) had a requirement to design and build a multiple field of view (FOV) optical system that could image the 1 to 5 mu m spectral band utilizing a single, cooled infrared detector. The primary challenge of designing this particular optical system was to get the 1 to 2 (SWIR) mu m band to focus at the same image plane as the 3 to 5 (MWIR) mu m band in all FOVs. A three-FOV broadband optical system that can image the 1 to 5 mu m band on the same image plane was designed and built. Several optical concepts were looked at, and it was decided that a combination of a reflective afocal and refractive imager was the best way to meet the system requirements. The use of a catadioptric system with a single focal plane that images in the 1 to 5 mu m spectrum reduces the size of the system and provides the user with see-spot capability. (C) 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)
C1 [Lilley, Scott; Vizgaitis, Jay] USA, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
[Everett, Jonathan; Spinazzola, Robert] Gen Dynam Global Imaging Technol, Nashua, NH 03060 USA.
RP Lilley, S (reprint author), USA, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
EM scott.j.lilley.civ@mail.mil
NR 9
TC 1
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U1 3
U2 7
PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA
SN 0091-3286
J9 OPT ENG
JI Opt. Eng.
PD JUN
PY 2013
VL 52
IS 6
AR 061303
DI 10.1117/1.OE.52.6.061303
PG 8
WC Optics
SC Optics
GA 151EV
UT WOS:000319444400003
ER
PT J
AU Lohrmann, D
Littleton, R
Reese, C
Murphy, D
Vizgaitis, J
AF Lohrmann, Dieter
Littleton, Roy
Reese, Colin
Murphy, Dan
Vizgaitis, Jay
TI Uncooled long-wave infrared small pixel focal plane array and system
challenges
SO OPTICAL ENGINEERING
LA English
DT Article
DE uncooled; bolometer; infrared detector; focal plane arrays; infrared
imaging
AB There is a strong motivation for smaller pixels based on enduser demand for lower-cost, higher-resolution camera systems both for military and commercial applications. Uncooled detector technology fits the need for a low size, weight, and power system. We explore the trade-offs and challenges to achieving pixel designs smaller than the current 17-mu m state-of-the-art detectors without loss in sensitivity or resolution. For illustration we consider a 12-mu m design. We also address modulation transfer function issues as the pixel size shrinks, and examine the difference between the performance of present devices and the theoretical performance limit for uncooled detectors. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
C1 [Lohrmann, Dieter; Littleton, Roy; Reese, Colin; Murphy, Dan; Vizgaitis, Jay] USA, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA.
RP Lohrmann, D (reprint author), USA, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA.
EM dieter.j.lohrmann.civ@mail.mil
NR 12
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U1 0
U2 14
PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA
SN 0091-3286
EI 1560-2303
J9 OPT ENG
JI Opt. Eng.
PD JUN
PY 2013
VL 52
IS 6
AR 061305
DI 10.1117/1.OE.52.6.061305
PG 6
WC Optics
SC Optics
GA 151EV
UT WOS:000319444400005
ER
PT J
AU Vizgaitis, JN
Hastings, A
AF Vizgaitis, Jay N.
Hastings, Arthur, Jr.
TI Dual band infrared picture-in-picture systems
SO OPTICAL ENGINEERING
LA English
DT Article
DE dual band; mid-wave infrared; long-wave infrared; infrared;
picture-in-picture; optics
AB Dual band infrared focal plane arrays (FPA) are designed to act as two independent focal planes located at a common image plane which detects both the mid-wave infrared and the long-wave infrared images. The imagery produced is simultaneous and separable for the two bands. Systems utilizing these focal planes have often been designed to operate the same way as single band infrared sensors, except that two images of the same scene but different spectral bands are simultaneously captured, and displayed independently or as a fused image. An alternative method of exploiting dual band FPA is to utilize the dual band nature of the focal plane to simultaneously view different scenes. It is feasible to provide a picture-in-picture capability where one spectral band views a narrow field of view (FOV) to identify targets while the other spectral band images the wide FOV to provide situational awareness. We explore this capability, including design concepts and issues associated with the development of a dual band picture-in-picture infrared system. (C) 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)
C1 [Vizgaitis, Jay N.; Hastings, Arthur, Jr.] USA, Night Vision & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
RP Vizgaitis, JN (reprint author), USA, Night Vision & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
EM jay.n.vizgaitis.civ@mail.mil
NR 7
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U1 1
U2 2
PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA
SN 0091-3286
J9 OPT ENG
JI Opt. Eng.
PD JUN
PY 2013
VL 52
IS 6
AR 061306
DI 10.1117/1.OE.52.6.061306
PG 8
WC Optics
SC Optics
GA 151EV
UT WOS:000319444400006
ER
PT J
AU Stepanov, V
Willey, TM
Ilavsky, J
Gelb, J
Qiu, HW
AF Stepanov, Victor
Willey, Trevor M.
Ilavsky, Jan
Gelb, Jeff
Qiu, Hongwei
TI Structural Characterization of RDX-Based Explosive Nanocomposites
SO PROPELLANTS EXPLOSIVES PYROTECHNICS
LA English
DT Article
DE Nanoenergetics; RDX; Voids; USAXS; X-ray microscopy
ID X-RAY-SCATTERING; POROSITY; IMPACT
AB Recently developed cyclotrimethylene trinitramine (RDX)-based nanostructured explosive compositions were shown to exhibit greatly reduced initiation sensitivity as compared to conventional compositions prepared with coarser, micrometer-scale RDX. In particular, improvements were shown in the sensitivity towards shock and impact stimuli, key sources of inadvertent initiation. Such an improved response to mechanical stimuli is believed to be largely a result of smaller crystal and void sizes. Characterization of these structural parameters is therefore necessary in order to construct a meaningful physical description of these novel explosive compositions. Herein, we report the results of a detailed structural characterization of these novel RDX-based nanocomposites. The analyzed specimens were in pellet form with nominally 10% porosity. These results constitute an unprecedentedly complete structural picture of this new class of energetic materials.
C1 [Stepanov, Victor] USA, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA.
[Willey, Trevor M.] Lawrence Livermore Natl Lab, Livermore, CA 94550 USA.
[Ilavsky, Jan] Argonne Natl Lab, Adv Photon Source, Argonne, IL 60439 USA.
[Gelb, Jeff] Xradia Inc, Pleasanton, CA 94588 USA.
[Qiu, Hongwei] Stevens Inst Technol, Dept Chem Engn & Mat Sci, Hoboken, NJ 07030 USA.
RP Stepanov, V (reprint author), USA, RDECOM ARDEC, B 3028, Picatinny Arsenal, NJ 07806 USA.
EM victor.stepanov.civ@mail.mil
RI USAXS, APS/D-4198-2013
FU National Science Foundation/Department of Energy [NSF/CHE-0822838]; U.S.
Department of Energy, Office of Science, Office of Basic Energy Sciences
[DE-AC02-06CH11357]; National Science Foundation through NSF
[DMR-0922522]
FX ChemMatCARS Sector 15 is principally supported by the National Science
Foundation/Department of Energy under grant number NSF/CHE-0822838. Use
of the Advanced Photon Source was supported by the U.S. Department of
Energy, Office of Science, Office of Basic Energy Sciences, under
Contract No. DE-AC02-06CH11357. Microscopy resources used in this work
were partially funded by the National Science Foundation through NSF
Grant DMR-0922522.
NR 23
TC 9
Z9 9
U1 2
U2 17
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY
SN 0721-3115
J9 PROPELL EXPLOS PYROT
JI Propellants Explos. Pyrotech.
PD JUN
PY 2013
VL 38
IS 3
BP 386
EP 393
DI 10.1002/prep.201200151
PG 8
WC Chemistry, Applied; Engineering, Chemical
SC Chemistry; Engineering
GA 160IP
UT WOS:000320113300011
ER
PT J
AU Walsh, MR
Walsh, ME
Taylor, S
Ramsey, CA
Ringelberg, DB
Zufelt, JE
Thiboutot, S
Ampleman, G
Diaz, E
AF Walsh, Michael R.
Walsh, Marianne E.
Taylor, Susan
Ramsey, Charles A.
Ringelberg, David B.
Zufelt, Jan E.
Thiboutot, Sonia
Ampleman, Guy
Diaz, Emmanuela
TI Characterization of PAX-21 Insensitive Munition Detonation Residues
SO PROPELLANTS EXPLOSIVES PYROTECHNICS
LA English
DT Article
DE Insensitive munitions; Energetic residues; Detonations; Blow-in-place;
Perchlorates
ID DEPOSITION RATES
AB Insensitive high explosives are being used in military munitions to counteract unintended detonations during storage and transportation. These formulations contain compounds such as 2,4-dinitroanisole (DNAN) and 3-nitro-1,2,4-triazol-5-one (NTO), which are less sensitive to shock and heat than conventional explosives. We conducted a series of four tests on snow-covered ice utilizing 60-mm mortar cartridges filled with 358g of PAX-21, a mixture of RDX, DNAN, and ammonium perchlorate. Rounds were detonated high- and low-order using a fuze simulator to initiate detonation. Blow-in-place (BIP) operations were conducted on fuzed rounds using an external donor charge or a shaped-charge initiator. Results indicate that 0.001% of the original mass of RDX and DNAN were deposited during high-order detonations, but up to 28% of the perchlorate remained. For the donor block BIPs, 1% of the RDX and DNAN remained. Residues masses for these operations were significantly higher than for conventional munitions. Low-order detonations deposited 10-15% of their original explosive filler in friable chunks up to 5.2g in mass. Shaped-charge BIPs scattered 15% of the filler and produced chunks up to 15g. Ammonium perchlorate residue masses were extremely high because of the presence of large AP crystals, up to 400m in the recovered particles.
C1 [Walsh, Michael R.; Walsh, Marianne E.; Taylor, Susan; Ringelberg, David B.; Zufelt, Jan E.] USA, Corps Engineers, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
[Ramsey, Charles A.] Envirostat Inc, Ft Collins, CO 80522 USA.
[Thiboutot, Sonia; Ampleman, Guy; Diaz, Emmanuela] Canada Valcartier, Def Res & Dev, Val Belair, PQ G3J 1X5, Canada.
RP Walsh, MR (reprint author), USA, Corps Engineers, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA.
EM Michael.Walsh@usace.army.mil
NR 21
TC 10
Z9 11
U1 0
U2 25
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY
SN 0721-3115
J9 PROPELL EXPLOS PYROT
JI Propellants Explos. Pyrotech.
PD JUN
PY 2013
VL 38
IS 3
BP 399
EP 409
DI 10.1002/prep.201200150
PG 11
WC Chemistry, Applied; Engineering, Chemical
SC Chemistry; Engineering
GA 160IP
UT WOS:000320113300013
ER
PT J
AU Moretti, JD
Sabatini, JJ
Shaw, AP
Chen, G
Gilbert, RA
Oyler, KD
AF Moretti, Jared D.
Sabatini, Jesse J.
Shaw, Anthony P.
Chen, Gary
Gilbert, Robert A., Jr.
Oyler, Karl D.
TI Prototype Scale Development of an Environmentally Benign Yellow Smoke
Hand-Held Signal Formulation Based on Solvent Yellow 33
SO ACS SUSTAINABLE CHEMISTRY & ENGINEERING
LA English
DT Article
DE Hand-held signal; Solvent Yellow 33; Energetic materials; Pyrotechnics;
Sustainable chemistry; Product life cycle management
ID PERCHLORATE-FREE; THERMAL-DECOMPOSITION; CIVILIAN APPLICATIONS; LIGHT
ILLUMINANTS; PYROTECHNICS; HYDROMAGNESITE; MILITARY
AB We report herein the development of an environmentally benign yellow smoke formulation aimed to replace the environmentally hazardous mixture currently specified for the U.S. Army's M194 yellow smoke hand-held signal. Static ignition test measurements have identified a replacement candidate that generates a robust fountain of yellow smoke, burning for 15 s from a consolidated cardboard tube configuration. This new formulation meets the burn time parameters outlined in the military requirement and is composed entirely of dry, powdered, solid ingredients without the need for solvent-based binders. In addition, this formulation was found to have relatively low sensitivity to impact, friction, and electrostatic discharge.
C1 [Moretti, Jared D.; Sabatini, Jesse J.; Shaw, Anthony P.; Chen, Gary; Gilbert, Robert A., Jr.] USA, Pyrotech Technol & Prototyping Div, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA.
[Oyler, Karl D.] USA, Explos Dev Branch, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA.
RP Moretti, JD (reprint author), USA, Pyrotech Technol & Prototyping Div, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA.
EM jared.d.moretti.civ@mail.mil; jesse.j.sabatini.civ@mail.mil
FU Ordnance Environmental Program - Environmental Quality Technology
(OEP-EQT) program of the U.S. Army Research, Development, and
Engineering Command (RDECOM)
FX The authors gratefully acknowledge the Ordnance Environmental Program -
Environmental Quality Technology (OEP-EQT) program of the U.S. Army
Research, Development, and Engineering Command (RDECOM) for funding this
work. Special thanks are due to Dr. Rajendra K. Sadangi for performing
powder XRD analysis of
Mg5(CO3)4(OH)2center dot
4H2O, and to Mr. Eric A. Latalladi and Mr. Steve Taggart for
performing all pilot plant operations. This manuscript has been approved
by the U.S. government for public release; distribution is unlimited.
NR 32
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U2 3
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2168-0485
J9 ACS SUSTAIN CHEM ENG
JI ACS Sustain. Chem. Eng.
PD JUN
PY 2013
VL 1
IS 6
BP 673
EP 678
DI 10.1021/sc400073p
PG 6
WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY;
Engineering, Chemical
SC Chemistry; Science & Technology - Other Topics; Engineering
GA 159AD
UT WOS:000320015500016
ER
PT J
AU Yin, WH
Xu, F
Ertorer, O
Pan, Z
Zhang, XY
Kecskes, LJ
Lavernia, EJ
Wei, Q
AF Yin, W. H.
Xu, F.
Ertorer, O.
Pan, Z.
Zhang, X. Y.
Kecskes, L. J.
Lavernia, E. J.
Wei, Q.
TI Mechanical behavior of microstructure engineered multi-length-scale
titanium over a wide range of strain rates
SO ACTA MATERIALIA
LA English
DT Article
DE Titanium; Ti; Microstructure; Mechanical behavior; Adiabatic shear band
ID SHEAR-BAND FORMATION; SEVERE PLASTIC-DEFORMATION; CHANNEL ANGULAR
EXTRUSION; HIGH-TENSILE DUCTILITY; ALPHA-TITANIUM; HYDROGEN
EMBRITTLEMENT; FLOW-STRESS; NANOCRYSTALLINE MATERIALS; INTERSTITIAL
SOLUTES; LOCALIZATION THEORY
AB In this work, we studied the mechanical behavior of commercial purity Ti powder consolidates with an engineered microstructure containing multiple-length-scale features, over a wide range of loading rates. The microstructural length scales were engineered by mixing powders of different sizes, followed by either hot quasi-isostatic forging (QIF) or spark plasma sintering (SPS). We used electron back-scatter diffraction and transmission electron microscopy to examine the microstructure of the Ti materials. A bimodal grain size distribution has been achieved for the majority of the QIFed samples, while those consolidated via SPS exhibit a near-equiaxed morphology. All samples synthesized with powders milled in liquid argon show considerable uniform plastic deformation under quasi-static compression, with no failure, and their strength values are considerably high when compared to those of commercial purity Ti. Moreover, the materials consolidated from milled powders exhibit adiabatic shear banding under high rate uniaxial compression via the Kolsky bar technique. Samples prepared from a preselected proportion of powders milled in liquid nitrogen showed quasi-static strength as high as 2000 MPa, and dynamic peak stress as high as 2700 MPa, comparable to the strength of high-strength steels. However, these super-strong Ti samples are brittle under both quasi-static and dynamic compression. The strengthening of these Ti materials with an engineered microstructure is primarily attributed to the presence of interstitials. Twins were observed in nanometer-sized grains in the strongest and brittle samples, along with evidence of the TiN phase, which was attributed to exposure to a high level of nitrogen introduced during milling in liquid nitrogen. The high rate behavior can be rationalized on the basis of an adiabatic shear band model that takes into account strain and strain rate hardening. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
C1 [Yin, W. H.; Pan, Z.; Wei, Q.] Univ N Carolina, Dept Mech Engn & Engn Sci, Charlotte, NC 28223 USA.
[Xu, F.; Zhang, X. Y.] Chongqing Univ, Sch Mat Sci & Engn, Chongqing 400030, Peoples R China.
[Ertorer, O.; Lavernia, E. J.] Univ Calif Davis, Dept Chem Engn & Mat Sci, Davis, CA 95616 USA.
[Kecskes, L. J.] USA, WMRD, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Lavernia, EJ (reprint author), Univ Calif Davis, Dept Chem Engn & Mat Sci, Davis, CA 95616 USA.
EM lavernia@ucdavis.edu; qwei@uncc.edu
RI Wei, Qiuming/B-7579-2008; Lavernia, Enrique/I-6472-2013; Kecskes,
Laszlo/F-6880-2014; Pan, Zhiliang/A-8061-2009
OI Lavernia, Enrique/0000-0003-2124-8964; Kecskes,
Laszlo/0000-0002-1342-3729; Pan, Zhiliang/0000-0003-3899-8761
FU US Army Research Laboratory [W911QX-06-C-0124, W911QX-08-C-0073]; NSF
[DMR-1210437]; ONR [N00014-12-1-0237]; National Natural Science
Foundation of China [51071183, 51271208]; Fundamental Research Funds for
the Central Universities [CDJXS11132225]; Major State Basic Research
Development Program of China (973 Program) [2010CB631004]
FX This work has been supported by the US Army Research Laboratory under
Contract Nos. W911QX-06-C-0124 and W911QX-08-C-0073. E.J. Lavernia
gratefully acknowledges support by NSF Grant DMR-1210437 and ONR Grant
N00014-12-1-0237. X.Y. Zhang thanks the National Natural Science
Foundation of China (Contract Nos. 51071183, 51271208), Fundamental
Research Funds for the Central Universities (Contract No. CDJXS11132225)
and Major State Basic Research Development Program of China (973
Program) (Contract No. 2010CB631004). We would like to thank Dr.
Mathaudhu for helpful discussion.
NR 89
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U1 2
U2 80
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1359-6454
EI 1873-2453
J9 ACTA MATER
JI Acta Mater.
PD JUN
PY 2013
VL 61
IS 10
BP 3781
EP 3798
DI 10.1016/j.actamat.2013.03.011
PG 18
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA 149FM
UT WOS:000319304400023
ER
PT J
AU Subhash, G
Ghosh, D
Blaber, J
Zheng, JQ
Halls, V
Masters, K
AF Subhash, Ghatu
Ghosh, Dipankar
Blaber, Justin
Zheng, James Q.
Halls, Virginia
Masters, Karl
TI Characterization of the 3-D amorphized zone beneath a Vickers
indentation in boron carbide using Raman spectroscopy
SO ACTA MATERIALIA
LA English
DT Article
DE Boron carbide; Amorphization; Micro-Raman spectroscopy; Vickers
indentation
ID VIBRATIONAL PROPERTIES; ATOMIC-STRUCTURE; SILICON-CARBIDE; CRACK SYSTEM;
CERAMICS; DAMAGE; HARDNESS; PLASTICITY; PRESSURE; BEHAVIOR
AB In boron carbide (B4C), the loss of crystallinity (i.e. amorphization) during high-pressure loading is known to result in reduced hardness and inferior ballistic performance. In this investigation, a systematic procedure is developed to evaluate the size and shape of the amorphized zone as well as the spatial distribution of the amorphization intensity beneath a Vickers indentation. This is accomplished by successive metallographic polishing and material removal from the indented surface at submicron depth increments and then scanning of each surface using micro-Raman spectrometry to construct a three-dimensional map of the amorphized zone. The amorphized zone in B4C extends to a depth of almost seven times the indentation depth. The self-similarity in stress fields at various depths is also confirmed from quantitative description of the Raman peaks for various loads. Damage evolution in the form of a Mescall zone and initiation of radial cracking from the amorphized zone were also observed. It is inferred that the amorphization process initiates as soon as the indenter tip makes contact with the B4C surface and thereafter the indenter penetrates into the weakened amorphized material. The implications of this observation and the utility of the quantitative information on the size and shape of the measured amorphized zone for calibration of multiscale models on structural changes in B4C are discussed. (c) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
C1 [Subhash, Ghatu; Ghosh, Dipankar; Blaber, Justin] Univ Florida, Dept Mech & Aerosp Engn, Gainesville, FL 32611 USA.
[Ghosh, Dipankar] CALTECH, Div Engn & Appl Sci, Pasadena, CA 91125 USA.
[Blaber, Justin] Georgia Inst Technol, Dept Mech Engn, Atlanta, GA 30332 USA.
[Zheng, James Q.; Halls, Virginia; Masters, Karl] USA, Program Execut Off Soldier, Ft Belvoir, VA 22060 USA.
RP Subhash, G (reprint author), Univ Florida, Dept Mech & Aerosp Engn, Gainesville, FL 32611 USA.
EM subhash@ufl.edu
NR 34
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U1 1
U2 54
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1359-6454
J9 ACTA MATER
JI Acta Mater.
PD JUN
PY 2013
VL 61
IS 10
BP 3888
EP 3896
DI 10.1016/j.actamat.2013.03.028
PG 9
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA 149FM
UT WOS:000319304400033
ER
PT J
AU Chang, JH
Warren, TK
Zhao, XS
Gill, T
Guo, F
Wang, LJ
Comunale, MA
Du, YM
Alonzi, DS
Yu, WQ
Ye, H
Liu, F
Guo, JT
Mehta, A
Cuconati, A
Butters, TD
Bavari, S
Xu, XD
Block, TM
AF Chang, Jinhong
Warren, Travis K.
Zhao, Xuesen
Gill, Tina
Guo, Fang
Wang, Lijuan
Comunale, Mary Ann
Du, Yanming
Alonzi, Dominic S.
Yu, Wenquan
Ye, Hong
Liu, Fei
Guo, Ju-Tao
Mehta, Anand
Cuconati, Andrea
Butters, Terry D.
Bavari, Sina
Xu, Xiaodong
Block, Timothy M.
TI Small molecule inhibitors of ER alpha-glucosidases are active against
multiple hemorrhagic fever viruses
SO ANTIVIRAL RESEARCH
LA English
DT Article
DE ER alpha-glucosidase; Imino sugar; Hemorrhagic fever virus; Ebola virus;
Marburg virus
ID VIRAL DIARRHEA VIRUS; SUGAR N-BUTYLDEOXYNOJIRIMYCIN; LETHAL MOUSE MODEL;
HEPATITIS-C VIRUS; DENGUE VIRUS; FILOVIRUS INFECTIONS; ANTIVIRAL
ACTIVITY; B-VIRUS; GLYCOSYLATION; DERIVATIVES
AB Host cellular endoplasmic reticulum alpha-glucosidases I and II are essential for the maturation of viral glycosylated envelope proteins that use the calnexin mediated folding pathway. Inhibition of these glycan processing enzymes leads to the misfolding and degradation of these viral glycoproteins and subsequent reduction in virion secretion. We previously reported that, CM-10-18, an imino sugar alpha-glucosidase inhibitor, efficiently protected the lethality of dengue virus infection of mice. In the current study, through an extensive structure-activity relationship study, we have identified three CM-10-18 derivatives that demonstrated superior in vitro antiviral activity against representative viruses from four viral families causing hemorrhagic fever. Moreover, the three novel imino sugars significantly reduced the mortality of two of the most pathogenic hemorrhagic fever viruses, Marburg virus and Ebola virus, in mice. Our study thus proves the concept that imino sugars are promising drug candidates for the management of viral hemorrhagic fever caused by variety of viruses. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Chang, Jinhong; Zhao, Xuesen; Gill, Tina; Guo, Fang; Wang, Lijuan; Comunale, Mary Ann; Liu, Fei; Guo, Ju-Tao; Mehta, Anand; Block, Timothy M.] Drexel Univ, Coll Med, Dept Microbiol & Immunol, Drexel Inst Biotechnol & Virol Res, Doylestown, PA 18902 USA.
[Warren, Travis K.; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD USA.
[Du, Yanming; Yu, Wenquan; Ye, Hong; Cuconati, Andrea; Xu, Xiaodong; Block, Timothy M.] Inst Hepatitis & Virus Res, Doylestown, PA USA.
[Alonzi, Dominic S.; Butters, Terry D.] Univ Oxford, Glycobiol Inst, Oxford, England.
[Xu, Xiaodong] Enantigen Therapeut Inc, Doylestown, PA USA.
RP Chang, JH (reprint author), Drexel Univ, Coll Med, Dept Microbiol & Immunol, Drexel Inst Biotechnol & Virol Res, 3805 Old Easton Rd, Doylestown, PA 18902 USA.
EM jinhong.chang@drexelmed.edu
RI LIU, FEI/H-2783-2013
FU Transformational Medical Technologies program from the Department of
Defense Chemical and Biological Defense program through the Defense
Threat Reduction Agency (DTRA) [HDTRA1-09-CHEM-BIO-BAA]; NIH [AI061441,
AI084267-0109]; Hepatitis B Foundation through Commonwealth of
Pennsylvania; Glycobiology Institute
FX We thank Matthew Campagna for technical support. This project was
supported by Transformational Medical Technologies program contract
[HDTRA1-09-CHEM-BIO-BAA] from the Department of Defense Chemical and
Biological Defense program through the Defense Threat Reduction Agency
(DTRA), NIH grants (AI061441 and AI084267-0109) and by the Hepatitis B
Foundation through an appropriation from the Commonwealth of
Pennsylvania. DAS and TDB thank the Glycobiology Institute for support.
NR 45
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U1 2
U2 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-3542
J9 ANTIVIR RES
JI Antiviral Res.
PD JUN
PY 2013
VL 98
IS 3
BP 432
EP 440
DI 10.1016/j.antiviral.2013.03.023
PG 9
WC Pharmacology & Pharmacy; Virology
SC Pharmacology & Pharmacy; Virology
GA 162WJ
UT WOS:000320296400011
PM 23578725
ER
PT J
AU Wu, XW
Walters, TJ
Rathbone, CR
AF Wu, Xiaowu
Walters, Thomas J.
Rathbone, Christopher R.
TI Skeletal muscle satellite cell activation following cutaneous burn in
rats
SO BURNS
LA English
DT Article
DE Muscle precursor cell; Thermal injury; Atrophy; Skeletal muscle;
Activation
ID HEPATOCYTE GROWTH-FACTOR; HYPERMETABOLIC RESPONSE; PROTEIN BREAKDOWN;
INJURY; EXPRESSION; APOPTOSIS; FIBERS; PROLIFERATION; HYPERTROPHY;
DYSFUNCTION
AB Background: Cutaneous burn distant from skeletal muscles induces atrophy; however, its effect on muscle stem cells resident in skeletal muscle (satellite cells) distal to burn is not known.
Methods: Satellite cell activation was measured in predominantly fast-twitch [tibialis anterior, extensor digitorum longus (EDL), plantaris, and gastrocnemius] and slow-twitch (soleus) muscles of rats that received either 40% total body surface area full-thickness scald burn or sham burn to the trunk area by determining bromodeoxyuridine incorporation, MyoD, and Pax7 immunohistochemistry in vivo <= 48 h after burn. To determine the effects of circulating factors on satellite cell activation, satellite cell cultures were treated with serum from sham or burn rats.
Results: In vivo activation of satellite cells was increased in fast muscles isolated from burn as compared to sham animals, whereas a significant response was not seen in slow muscles. Serum taken from animals in the burn group increased the activation of satellite cells isolated from both sham and burn animals in vitro, suggesting that circulating factors have the potential to increase satellite cell activation following burn.
Conclusions: Increases in satellite cell activation in muscles distal to burn are fiber-type-dependent, and circulating factors may play a role in the activation of satellite cells following burn. A better understanding of the impact of burn on satellite cell functionality will allow us to identify the cellular mechanisms of long-term muscle atrophy. (c) 2012 Elsevier Ltd and ISBI. All rights reserved.
C1 [Wu, Xiaowu; Walters, Thomas J.; Rathbone, Christopher R.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Wu, XW (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM xiaowu.wu@amedd.army.mil
FU United States Army Medical Research and Materiel Command
FX We thank Ms. Melissa Sanchez for expert technical assistance. Research
was supported by United States Army Medical Research and Materiel
Command. The opinions or assertions contained herein are the private
views of the author and are not to be construed as official or
reflecting the views of the US Department of Defense or the US
Government. The author is an employee of the US Government. This work
was prepared as part of his official duties and, as such, there is no
copyright to be transferred.
NR 48
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U1 0
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
J9 BURNS
JI Burns
PD JUN
PY 2013
VL 39
IS 4
BP 736
EP 744
DI 10.1016/j.burns.2012.10.016
PG 9
WC Critical Care Medicine; Dermatology; Surgery
SC General & Internal Medicine; Dermatology; Surgery
GA 161RC
UT WOS:000320210000028
PM 23146573
ER
PT J
AU Seay, JF
Sauer, SG
Frykman, PN
Roy, TC
AF Seay, Joseph F.
Sauer, Shane G.
Frykman, Peter N.
Roy, Tanja C.
TI A history of low back pain affects pelvis and trunk mechanics during a
sustained lift/lower task
SO ERGONOMICS
LA English
DT Article
DE box lift lower; biomechanics; kinematics; physiology; manual materials
handling; low back pain
ID RISK-FACTORS; LIFTING EXERTIONS; LUMBAR SPINE; MOMENTS; LOAD;
COORDINATION; RECURRENCE; DISORDERS; STABILITY; INJURY
AB This study compared three-dimensional trunk and pelvis range of motion (ROM) during a sustained asymmetric box lift/lower task between a group with a history of low back pain (HBP, n=9) and a group with no history of low back pain (NBP, n=9). Participants lifted an 11-kg box for 10 min at 12 cycles/min from ankle height in front to shelves 45 deg off-centre at waist height. Kinematic data were collected at the beginning (min1), middle (min5) and end of the bout (min9). Two-way analyses of variance were performed for all variables. Pelvis and trunk transverse ROM were similar at min1. By min9, HBP group did not change (31.9 +/- 9 deg); however, ROM decreased in NBP group (21.6 +/- 6 deg, p < 0.05). Therefore, despite no current pain, the HBP group demonstrated protective lifting mechanics compared to controls. Also discussed are implications for studying lifting paradigms at sub-maximal effort over longer periods of time.
Practitioner summary: Differences between groups over time demonstrate residual consequences of low back pain (LBP) in a manual materials handling scenario. Individuals with a history of LBP (pain free for 6 months) demonstrated more conservative lifting mechanics towards the end of the bout compared to controls with no history of LBP.
C1 [Seay, Joseph F.; Sauer, Shane G.; Frykman, Peter N.; Roy, Tanja C.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA.
RP Seay, JF (reprint author), US Army Res Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA.
EM joseph.seay@us.army.mil
FU USARIEM
FX The opinions or assertions contained herein are the private views of the
author(s) and are not to be construed as official or reflecting the
views of the United States Army or the Department of Defence. Approved
for public release; distribution is unlimited. Research supported in
part by appointments to the Postgraduate Research Participation Program
(SGS) funded by USARIEM and administered by Oak Ridge Institute for
Science and Engineering.
NR 36
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U1 1
U2 18
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0014-0139
J9 ERGONOMICS
JI Ergonomics
PD JUN 1
PY 2013
VL 56
IS 6
BP 944
EP 953
DI 10.1080/00140139.2013.781234
PG 10
WC Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology
SC Engineering; Psychology
GA 166UC
UT WOS:000320582800005
PM 23586619
ER
PT J
AU Cho, JH
Chan, KS
AF Cho, Jin-Hee
Chan, Kevin S.
TI Building Trust-Based Sustainable Networks
SO IEEE TECHNOLOGY AND SOCIETY MAGAZINE
LA English
DT Article
ID TECHNOLOGY DEVELOPMENT; EVOLUTION
C1 [Cho, Jin-Hee; Chan, Kevin S.] USA, Res Lab, CISD, USARL, Adelphi, MD 20783 USA.
RP Cho, JH (reprint author), USA, Res Lab, CISD, USARL, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM jin-hee.cho.civ@mail.mil
FU Department of Defense (DoD) through the office of the Assistant
Secretary of Defense for Research and Engineering (ASD (RE))
FX This research was partially supported by the Department of Defense (DoD)
through the office of the Assistant Secretary of Defense for Research
and Engineering (ASD (R&E)). The views and opinions of the author(s) do
not reflect those of the DoD nor ASD (R&E). We also thank ARL's graphic
designer, John A. Foster, for graphics used in this work.
NR 21
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Z9 2
U1 1
U2 9
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0278-0097
J9 IEEE TECHNOL SOC MAG
JI IEEE Technol. Soc. Mag.
PD SUM
PY 2013
VL 32
IS 2
BP 32
EP 38
DI 10.1109/MTS.2013.2259311
PG 7
WC Engineering, Electrical & Electronic
SC Engineering
GA 160OD
UT WOS:000320128100006
ER
PT J
AU Murphy, JP
Mullins, MJ
Barnes, PN
Haugan, TJ
Levin, GA
Majoros, M
Sumption, MD
Collings, EW
Polak, M
Mozola, P
AF Murphy, John P.
Mullins, Matthew J.
Barnes, Paul N.
Haugan, Timothy J.
Levin, George A.
Majoros, Milan
Sumption, Michael D.
Collings, Edward W.
Polak, Milan
Mozola, Pavol
TI Experiment Setup for Calorimetric Measurements of Losses in HTS Coils
Due to AC Current and External Magnetic Fields
SO IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY
LA English
DT Article
DE AC losses; calorimetric measurement; magnetic field
ID YBCO COATED CONDUCTORS; FREQUENCIES
AB We present a design and details of construction of two calorimetric systems that allow us to measure the total loss in high temperature superconducting coils or linear samples carrying alternating current while exposed to a strong alternating magnetic field. This measurement technique is based on the boil-off of liquid nitrogen. The first system is designed to measure ac losses in superconducting coils in self-field generated by AC transport current. The second system contains a permanent magnet rotor and simulates the environment of an electric motor or generator. The sensitivity of the system is such that it can measure low losses from a few milliwatts to several hundred milliwatts, in either a static or dynamic magnetic field.
C1 [Murphy, John P.] Univ Dayton, Res Inst, Dayton, OH 45469 USA.
[Mullins, Matthew J.] USAF, Res Lab, Wright Patterson AFB, OH USA.
[Barnes, Paul N.] USA, Energy & Power Div, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA.
[Haugan, Timothy J.] USAF, Aerosp Syst Directorate, Res Lab, Wright Patterson AFB, OH 45433 USA.
[Levin, George A.] UES, Dayton, OH 45432 USA.
[Majoros, Milan; Sumption, Michael D.; Collings, Edward W.] Ohio State Univ, Columbus, OH 43210 USA.
[Polak, Milan; Mozola, Pavol] Slovak Acad Sci, Bratislava 84104, Slovakia.
RP Murphy, JP (reprint author), Univ Dayton, Res Inst, Dayton, OH 45469 USA.
EM john.murphy.ctr@wpafb.af.mil; manaman22@gmail.com;
paul.n.barnes.civ@mail.mil; timothy.haugan@wpafb.af.mil;
george.levin.ctr@wpafb.af.mil; majoros@matsceng.ohio-state.edu;
sumption@matsceng.ohio-state.edu; collings@ecr6.ohio-state.edu;
milan.polak@savba.sk; pavol.mozola@savba.sk
RI Sumption, Mike/N-5913-2016
OI Sumption, Mike/0000-0002-4243-8380
FU Air Force Research Laboratory; Air Force Office of Scientific Research;
European Office of Research and Development
FX This work was supported by the Air Force Research Laboratory, the Air
Force Office of Scientific Research, and its European Office of Research
and Development.
NR 18
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U1 3
U2 37
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1051-8223
J9 IEEE T APPL SUPERCON
JI IEEE Trans. Appl. Supercond.
PD JUN
PY 2013
VL 23
IS 3
AR 4701505
DI 10.1109/TASC.2013.2237939
PN 2
PG 5
WC Engineering, Electrical & Electronic; Physics, Applied
SC Engineering; Physics
GA 143VA
UT WOS:000318895100090
ER
PT J
AU Briggs, MJ
Kopp, PJ
Ankudinov, VK
Silver, AL
AF Briggs, Michael J.
Kopp, Paul J.
Ankudinov, Vladimir K.
Silver, Andrew L.
TI Comparison of Measured Ship Squat with Numerical and Empirical Methods
SO JOURNAL OF SHIP RESEARCH
LA English
DT Article
DE ship squat; numerical models; empirical formulas; ship measurements
AB The Beck, Newman and Tuck (BNT) numerical predictions are used in the Coastal and Hydraulics Laboratory (CHL) Channel Analysis and Design Evaluation Tool (CADET) model for predicting underkeel clearance (UKC) resulting from ship motions and squat. The Ankudinov empirical squat prediction formula has been used in the CHL ship simulator and was recently updated. The World Association for Waterborne Transport Infrastructure (formerly The Permanent International Association of Navigation Congresses, PIANC) has recommended several empirical and physics-based formulas for the prediction of ship squat. Some of the most widely used formulas include those of Barrass, Eryuzlu, Huuska, ICORELS, Romisch, Tuck, and Yoshimura. The purpose of this article is to compare BNT, Ankudinov, and PIANC predictions with measured DGPS squat data from the Panama Canal for four ships. These comparisons demonstrate that the BNT, Ankudinov, and PIANC predictions fall within the range of squat measurements and can be used with confidence in deep draft channel design.
C1 [Briggs, Michael J.] USA, Engn Res & Dev Ctr, Res Hydraul Engn Coastal & Hydraul Lab, Vicksburg, MS USA.
[Kopp, Paul J.] Naval Architect, Naval Surface Warfare Ctr, Carderock Div, Seakeeping Dept, West Bethesda, MD USA.
[Ankudinov, Vladimir K.] TRANSAS, Hydrodynam & Res Dept, Washington, DC USA.
[Silver, Andrew L.] Naval Surface Warfare Ctr, Carderock Div, Seakeeping Dept, West Bethesda, MD USA.
RP Briggs, MJ (reprint author), USA, Engn Res & Dev Ctr, Res Hydraul Engn Coastal & Hydraul Lab, Vicksburg, MS USA.
NR 32
TC 1
Z9 1
U1 3
U2 10
PU SOC NAVAL ARCH MARINE ENG
PI JERSEY CITY
PA 601 PAVONIA AVENUE, JERSEY CITY, NJ 07306 USA
SN 0022-4502
J9 J SHIP RES
JI J. Ship Res.
PD JUN
PY 2013
VL 57
IS 2
BP 73
EP 85
DI 10.5957/JOSR.57.1.120007
PG 13
WC Engineering, Marine; Engineering, Civil
SC Engineering
GA 164RP
UT WOS:000320427500001
ER
PT J
AU Tran, PK
Letowski, TR
McBride, ME
AF Tran, Phuong K.
Letowski, Tomasz R.
McBride, Maranda E.
TI The effect of bone conduction microphone placement on intensity and
spectrum of transmitted speech items
SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
LA English
DT Article
ID ACQUISITION TEST CAT; BACKGROUND-NOISE; INTELLIGIBILITY; AUDIOMETRY;
VIBRATOR; HEARING; DESIGN; GENDER
AB Speech signals can be converted into electrical audio signals using either conventional air conduction (AC) microphone or a contact bone conduction (BC) microphone. The goal of this study was to investigate the effects of the location of a BC microphone on the intensity and frequency spectrum of the recorded speech. Twelve locations, 11 on the talker's head and 1 on the collar bone, were investigated. The speech sounds were three vowels (/u/, /a/, /i/) and two consonants (/m/, /integral/). The sounds were produced by 12 talkers. Each sound was recorded simultaneously with two BC microphones and an AC microphone. Analyzed spectral data showed that the BC recordings made at the forehead of the talker were the most similar to the AC recordings, whereas the collar bone recordings were most different. Comparison of the spectral data with speech intelligibility data collected in another study revealed a strong negative relationship between BC speech intelligibility and the degree of deviation of the BC speech spectrum from the AC spectrum. In addition, the head locations that resulted in the highest speech intelligibility were associated with the lowest output signals among all tested locations. Implications of these findings for BC communication are discussed.
C1 [Tran, Phuong K.; Letowski, Tomasz R.] USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA.
[McBride, Maranda E.] North Carolina Agr & Tech State Univ, Dept Management, Sch Business & Econ, Greensboro, NC 27411 USA.
RP Tran, PK (reprint author), USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM phuong.k.tran.civ@mail.mil
NR 28
TC 2
Z9 2
U1 0
U2 5
PU ACOUSTICAL SOC AMER AMER INST PHYSICS
PI MELVILLE
PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA
SN 0001-4966
J9 J ACOUST SOC AM
JI J. Acoust. Soc. Am.
PD JUN
PY 2013
VL 133
IS 6
BP 3900
EP 3908
DI 10.1121/1.4803870
PG 9
WC Acoustics; Audiology & Speech-Language Pathology
SC Acoustics; Audiology & Speech-Language Pathology
GA 161EC
UT WOS:000320173600033
PM 23742344
ER
PT J
AU Turell, MJ
Byrd, BD
Harrison, BA
AF Turell, M. J.
Byrd, B. D.
Harrison, B. A.
TI POTENTIAL FOR POPULATIONS OF AEDES J. JAPONICUS TO TRANSMIT RIFT VALLEY
FEVER VIRUS IN THE USA
SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION
LA English
DT Article
DE Vector; transmission; North America
ID NORTH-AMERICAN MOSQUITOS; HOST-FEEDING PATTERNS; WEST-NILE-VIRUS; VECTOR
COMPETENCE; UNITED-STATES; ENCEPHALITIS-VIRUS; DIPTERA-CULICIDAE;
CULEX-ZOMBAENSIS; SAUDI-ARABIA; SOUTH-AFRICA
AB Aedes japonicus japonicus was introduced into the northeastern USA in 1998 and has since spread to more than 25 states. Because this species has been shown to be a competent laboratory vector of several viruses, readily feeds on large mammals, and has become a pest in several areas, there is concern that it might serve as a vector of Rift Valley fever virus (RVFV) should that virus be introduced into North America. Infection with RVFV causes mortality in >90% of young domestic ungulates (e. g., calves, kids, and lambs), as well as causing a febrile illness and occasional deaths in humans. Therefore, we evaluated Ae. j. japonicus captured in North Carolina and in Maryland for their ability to serve as potential vectors for RVFV. After feeding on infected adult hamsters, these mosquitoes were tested for infection, dissemination, and the ability to transmit RVFV after incubation at 26 degrees C for 7-28 days. Both the Maryland and North Carolina populations of Ae. j. japonicus were highly efficient laboratory vectors of RVFV, with infection rates >90% and dissemination rates >84% for those mosquitoes that fed on hamsters with viremias >= 10(8.5) plaque-forming units/ml. Thus, Ae. j. japonicus should be targeted for immediate control should RVFV be introduced into an area where this mosquito is now present.
C1 [Turell, M. J.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA.
[Byrd, B. D.; Harrison, B. A.] Western Carolina Univ, Coll Hlth & Human Sci, Cullowhee, NC 28723 USA.
RP Turell, MJ (reprint author), USA, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA.
FU US Department of Homeland Security Science and Technology Directorate
[HSHQDC-11-X-00326]
FX This work was supported by a grant HSHQDC-11-X-00326 from the US
Department of Homeland Security Science and Technology Directorate.
NR 44
TC 16
Z9 16
U1 0
U2 16
PU AMER MOSQUITO CONTROL ASSOC
PI MOUNT LAUREL
PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA
SN 8756-971X
J9 J AM MOSQUITO CONTR
JI J. Am. Mosq. Control Assoc.
PD JUN
PY 2013
VL 29
IS 2
BP 133
EP 137
DI 10.2987/12-6316r.1
PG 5
WC Entomology
SC Entomology
GA 161DI
UT WOS:000320171500006
PM 23923327
ER
PT J
AU Currano, LJ
Becker, CR
Lunking, D
Smith, GL
Isaacson, B
Thomas, L
AF Currano, Luke J.
Becker, Collin R.
Lunking, David
Smith, Gabriel L.
Isaacson, Brian
Thomas, Larry
TI Triaxial inertial switch with multiple thresholds and resistive ladder
readout
SO SENSORS AND ACTUATORS A-PHYSICAL
LA English
DT Article
DE Shock sensor; Acceleration switch; Accelerometer; Threshold; Inertial
switch; g-Switch; Archimedes spiral; Spring
ID ELECTROPLATING TECHNOLOGY; ACCELEROMETER ARRAY; FABRICATION; CIRCUIT;
SILICON
AB We describe the design, modeling, fabrication, and testing of a MEMS inertial switch that can detect accelerations in the x, y, and z axes using a single mass/spring assembly (first reported in Ref. [1]). A spiral spring suspension is used which is compliant in all directions. The inertial switch approach offers zero power draw until an acceleration event occurs. Arrays of individual triaxial sensors are created on a single chip, with each switch designed to close at a different acceleration threshold between 50 g and 250g. A resistor ladder connects each switch together in series such that the number of pinouts from the chip is substantially reduced. The response of the switch array to half-sine acceleration pulses of 5-8 ms duration is reported, with multiple switches in the array closing and opening in sequence for higher magnitude acceleration pulses. The switch closure time under these conditions is consistently less than 200 ps, and bounce is minimal for applied accelerations lower than 200g. Published by Elsevier B.V.
C1 [Currano, Luke J.; Becker, Collin R.; Smith, Gabriel L.] USA, Res Lab, Adelphi, MD 20783 USA.
[Lunking, David; Isaacson, Brian] Gen Tech Serv ARL, Adelphi, MD 20783 USA.
RP Currano, LJ (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM lcurrano@arl.army.mil
FU U.S. Army PM Solider Protection and Individual Equipment
FX The authors would like to acknowledge partial funding support for this
work from U.S. Army PM Solider Protection and Individual Equipment, and
specifically Mr. Karl Masters and Ms. Chris Perritt for their guidance
and support toward the eventual Traumatic Brain Injury monitoring
application.
NR 23
TC 5
Z9 7
U1 1
U2 17
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0924-4247
J9 SENSOR ACTUAT A-PHYS
JI Sens. Actuator A-Phys.
PD JUN 1
PY 2013
VL 195
BP 191
EP 197
DI 10.1016/j.sna.2012.06.029
PG 7
WC Engineering, Electrical & Electronic; Instruments & Instrumentation
SC Engineering; Instruments & Instrumentation
GA 160UC
UT WOS:000320145000028
ER
PT J
AU Kim, S
Zhang, X
Daugherty, R
Lee, E
Kunnen, G
Allee, DR
Forsythe, E
Chae, J
AF Kim, S.
Zhang, X.
Daugherty, R.
Lee, E.
Kunnen, G.
Allee, D. R.
Forsythe, E.
Chae, J.
TI Design and implementation of electrostatic micro-actuators in ultrasonic
frequency on a flexible substrate, PEN (polyethylene naphthalate)
SO SENSORS AND ACTUATORS A-PHYSICAL
LA English
DT Article
DE Ultrasonic actuator; MEMS actuator; Electrostatic actuator
ID TRANSDUCERS; PERFORMANCE; TECHNOLOGY
AB We present an electrostatic actuator fabricated on a flexible polyethylene naphthalate (PEN) substrate, which emits acoustic waves at ultrasonic frequencies. The MEMS actuator has a suspended parylene diaphragm which consists of 2-6 mm diameter and 6 mu m gap between the diaphragm and substrate. Driving circuitry consists of voltage controlled oscillator (VCO) and output buffer chain, and was fabricated by Arizona State University's Flexible Display Center-IC process. The fabricated actuator emits ultrasonic waves at 25 kHz, and acoustic sound pressure of 27 dB SPL (sound pressure level) driven by the hydrogenated amorphous silicon (a-Si:H) circuitry. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Kim, S.; Zhang, X.; Daugherty, R.; Lee, E.; Kunnen, G.; Allee, D. R.; Chae, J.] Arizona State Univ, Dept Elect Comp & Energy Engn, Tempe, AZ 85287 USA.
[Forsythe, E.] USA, Res Lab, Adelphi, MD 20783 USA.
RP Kim, S (reprint author), Arizona State Univ, Dept Elect Comp & Energy Engn, 650 E Tyler Mall, Tempe, AZ 85287 USA.
EM skim85@asu.edu
FU Army Research Laboratory [W911NG-04-2-0005]
FX The authors thank CSSER (Center for Solid-State Electronics Research)
staff at Arizona State University. This work was supported by Army
Research Laboratory under Cooperative Agreement W911NG-04-2-0005.
NR 26
TC 3
Z9 3
U1 0
U2 14
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0924-4247
J9 SENSOR ACTUAT A-PHYS
JI Sens. Actuator A-Phys.
PD JUN 1
PY 2013
VL 195
BP 198
EP 205
DI 10.1016/j.sna.2012.10.010
PG 8
WC Engineering, Electrical & Electronic; Instruments & Instrumentation
SC Engineering; Instruments & Instrumentation
GA 160UC
UT WOS:000320145000029
ER
PT J
AU Cliver, EW
Richardson, IG
Ling, AG
AF Cliver, E. W.
Richardson, I. G.
Ling, A. G.
TI Solar Drivers of 11-yr and Long-Term Cosmic Ray Modulation
SO SPACE SCIENCE REVIEWS
LA English
DT Review
DE Sun; Solar Cycle; Solar Wind; Coronal Mass Ejections; High-speed
Streams; Galactic Cosmic Rays; Cosmic Ray Modulation
ID CORONAL MASS EJECTIONS; HELIOSPHERIC CURRENT SHEET; DEPENDENT DRIFT
MODEL; MERGED INTERACTION REGIONS; NONAXISYMMETRIC OPEN FLUX; WIND
MAGNETIC-FIELD; VOYAGER-2 OBSERVATIONS; GEOMAGNETIC-ACTIVITY; PARTICLE
DRIFT; TILT ANGLE
AB In the current paradigm for the modulation of galactic cosmic rays (GCRs), diffusion is taken to be the dominant process during solar maxima while drift dominates at minima. Observations during the recent solar minimum challenge the pre-eminence of drift at such times. In 2009, the similar to 2 GV GCR intensity measured by the Newark neutron monitor increased by similar to 5% relative to its maximum value two cycles earlier even though the average tilt angle in 2009 was slightly larger than that in 1986 (similar to 20A degrees vs. similar to 14A degrees), while solar wind B was significantly lower (similar to 3.9 nT vs. similar to 5.4 nT). A decomposition of the solar wind into high-speed streams, slow solar wind, and coronal mass ejections (CMEs; including post-shock flows) reveals that the Sun transmits its message of changing magnetic field (diffusion coefficient) to the heliosphere primarily through CMEs at solar maximum and high-speed streams at solar minimum. Long-term reconstructions of solar wind B are in general agreement for the similar to 1900-present interval and can be used to reliably estimate GCR intensity over this period. For earlier epochs, however, a recent Be-10-based reconstruction covering the past similar to 10(4) years shows nine abrupt and relatively short-lived drops of B to a parts per thousand(2)0 nT, with the first of these corresponding to the Sporer minimum. Such dips are at variance with the recent suggestion that B has a minimum or floor value of similar to 2.8 nT. A floor in solar wind B implies a ceiling in the GCR intensity (a permanent modulation of the local interstellar spectrum) at a given energy/rigidity. The 30-40% increase in the intensity of 2.5 GV electrons observed by Ulysses during the recent solar minimum raises an interesting paradox that will need to be resolved.
C1 [Cliver, E. W.] USA, Space Vehicles Directorate, Res Lab, Hanscom Afb, MA USA.
[Richardson, I. G.] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA.
[Richardson, I. G.] Univ Maryland, Dept Astron, CRESST, College Pk, MD 20742 USA.
[Ling, A. G.] Atmospher & Environm Res Inc, Lexington, MA USA.
RP Cliver, EW (reprint author), USA, Space Vehicles Directorate, Res Lab, Hanscom Afb, MA USA.
EM afrl.rvb.pa@hanscom.af.mil
OI Richardson, Ian/0000-0002-3855-3634
FU AFRL [FA8718-05-C-0036]
FX It is a pleasure to thank Jurg Beer, Bernd Heber, Randy Jokipii, Jozsef
Kota, Frank McDonald, Harm Moraal, and Rudolf von Steiger for organizing
this timely and stimulating workshop. In addition, we are grateful to
Marius Potgieter for constructive criticism. A.G.L. acknowledges support
from AFRL contract FA8718-05-C-0036.
NR 75
TC 22
Z9 22
U1 0
U2 9
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0038-6308
J9 SPACE SCI REV
JI Space Sci. Rev.
PD JUN
PY 2013
VL 176
IS 1-4
BP 3
EP 19
DI 10.1007/s11214-011-9746-3
PG 17
WC Astronomy & Astrophysics
SC Astronomy & Astrophysics
GA 163ZX
UT WOS:000320379200002
ER
PT J
AU Zhang, P
Gao, XG
Ishida, H
Amnuaysirikul, J
Weina, PJ
Grogl, M
O'Neil, MT
Li, QG
Caridha, D
Ohrt, C
Hickman, M
Magill, AJ
Ray, P
AF Zhang, Peng
Gao, Xiugong
Ishida, Hiroshi
Amnuaysirikul, Jack
Weina, Peter J.
Grogl, Max
O'Neil, Michael T.
Li, Qigui
Caridha, Diana
Ohrt, Colin
Hickman, Mark
Magill, Alan J.
Ray, Prabhati
TI An In vivo Drug Screening Model Using Glucose-6-Phosphate Dehydrogenase
Deficient Mice to Predict the Hemolytic Toxicity of 8-Aminoquinolines
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID PRIMAQUINE; MALARIA; THERAPY
AB Anti-malarial 8-aminoquinolines drugs cause acute hemolytic anemia in individuals with glucose-6-phosphate dehydrogenase deficiency (G6PDD). Efforts to develop non-hemolytic 8-aminoquinolines have been severely limited caused by the lack of a predictive in vivo animal model of hemolytic potential that would allow screening of candidate compounds. This report describes a G6PDD mouse model with a phenotype closely resembling the G6PDD phenotype found in the African A-type G6PDD human. These G6PDD mice, given different doses of primaquine, which used as a reference hemolytic drug, display a full array of hemolytic anemia parameters, consistently and reproducibly. The hemolytic and therapeutic indexes were generated for evaluation of hemotoxicity of drugs. This model demonstrated a complete hemolytic toxicity response to another known hemolytic antimalarial drug, pamaquine, but no response to non-hemolytic drugs, chloroquine and mefloquine. These results suggest that this model is suitable for evaluation of selected 8-AQ type candidate antimalarial drugs for their hemolytic potential.
C1 Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA.
Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD USA.
[Zhang, Peng; Gao, Xiugong; Ishida, Hiroshi; Amnuaysirikul, Jack; Weina, Peter J.; Grogl, Max; O'Neil, Michael T.; Li, Qigui; Caridha, Diana; Ohrt, Colin; Hickman, Mark; Magill, Alan J.; Ray, Prabhati] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
RP Ray, P (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
EM peng.zhang@amedd.army.mil; Xiugong.Gao@fda.hhs.gov;
hiroshi.ishida@amedd.army.mil; Jack.Amnuaysirikul@us.army.mil;
peter.weina@us.army.mil; Max.Grogl@amedd.army.mil;
michael.t.oneil@us.army.mil; Qigui.Li@us.army.mil;
Diana.Caridha2@us.army.mil; Colin.Ohrt@amedd.army.mil;
Mark.Hickman@amedd.army.mil; Alan.Magill@us.army.mil;
prabhati.say@us.army.mil
RI Weina, Peter/A-2120-2011
FU Military Infectious Diseases Research Program (MIDRP) Award
[RQ0031_09_WR]; U.S. Army Medical Research & Materiel Command (USAMRMC);
Telemedicine & Advanced Technology Research Center (TATRC), at Fort
Detrick, MD [W81XWH-07-2-0095]
FX This study was supported by the Military Infectious Diseases Research
Program (MIDRP) Award #RQ0031_09_WR and the U.S. Army Medical Research &
Materiel Command (USAMRMC) and the Telemedicine & Advanced Technology
Research Center (TATRC), at Fort Detrick, MD, under award number:
W81XWH-07-2-0095. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
NR 24
TC 2
Z9 2
U1 1
U2 5
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD JUN
PY 2013
VL 88
IS 6
BP 1138
EP 1145
DI 10.4269/ajtmh.12-0682
PG 8
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 158GO
UT WOS:000319957700020
PM 23530079
ER
PT J
AU Trejos, T
Koons, R
Becker, S
Berman, T
Buscaglia, J
Duecking, M
Eckert-Lumsdon, T
Ernst, T
Hanlon, C
Heydon, A
Mooney, K
Nelson, R
Olsson, K
Palenik, C
Pollock, EC
Rudell, D
Ryland, S
Tarifa, A
Valadez, M
Weis, P
Almirall, J
AF Trejos, Tatiana
Koons, Robert
Becker, Stefan
Berman, Ted
Buscaglia, JoAnn
Duecking, Marc
Eckert-Lumsdon, Tiffany
Ernst, Troy
Hanlon, Christopher
Heydon, Alex
Mooney, Kim
Nelson, Randall
Olsson, Kristine
Palenik, Christopher
Pollock, Edward Chip
Rudell, David
Ryland, Scott
Tarifa, Anamary
Valadez, Melissa
Weis, Peter
Almirall, Jose
TI Cross-validation and evaluation of the performance of methods for the
elemental analysis of forensic glass by mu-XRF, ICP-MS, and LA-ICP-MS
SO ANALYTICAL AND BIOANALYTICAL CHEMISTRY
LA English
DT Article
DE Elemental analysis; Forensic; Glass; X-ray fluorescence; ICP-MS; Laser
ablation ICP-MS
ID PLASMA-MASS-SPECTROMETRY; ATOMIC-EMISSION-SPECTROMETRY;
X-RAY-FLUORESCENCE; LASER-ABLATION; QUANTITATIVE-ANALYSIS; SAMPLING
STRATEGIES; REFRACTIVE-INDEX; FRAGMENTS; DISCRIMINATION; CLASSIFICATION
AB Elemental analysis of glass was conducted by 16 forensic science laboratories, providing a direct comparison between three analytical methods [micro-x-ray fluorescence spectroscopy (mu-XRF), solution analysis using inductively coupled plasma mass spectrometry (ICP-MS), and laser ablation inductively coupled plasma mass spectrometry]. Interlaboratory studies using glass standard reference materials and other glass samples were designed to (a) evaluate the analytical performance between different laboratories using the same method, (b) evaluate the analytical performance of the different methods, (c) evaluate the capabilities of the methods to correctly associate glass that originated from the same source and to correctly discriminate glass samples that do not share the same source, and (d) standardize the methods of analysis and interpretation of results. Reference materials NIST 612, NIST 1831, FGS 1, and FGS 2 were employed to cross-validate these sensitive techniques and to optimize and standardize the analytical protocols. The resulting figures of merit for the ICP-MS methods include repeatability better than 5 % RSD, reproducibility between laboratories better than 10 % RSD, bias better than 10 %, and limits of detection between 0.03 and 9 mu g g(-1) for the majority of the elements monitored. The figures of merit for the mu-XRF methods include repeatability better than 11 % RSD, reproducibility between laboratories after normalization of the data better than 16 % RSD, and limits of detection between 5.8 and 7,400 mu g g(-1). The results from this study also compare the analytical performance of different forensic science laboratories conducting elemental analysis of glass evidence fragments using the three analytical methods.
C1 [Trejos, Tatiana; Tarifa, Anamary; Almirall, Jose] Florida Int Univ, Int Forens Res Inst, Miami, FL 33199 USA.
[Koons, Robert; Buscaglia, JoAnn] Fed Bur Investigat, Lab Div, Counterterrorism & Forens Sci Res Unit, Quantico, VA 22135 USA.
[Becker, Stefan; Duecking, Marc; Weis, Peter] Bundeskriminalamt BKA, Forens Sci Inst, D-65173 Wiesbaden, Germany.
[Berman, Ted; Ryland, Scott] Orlando Reg Operat Ctr, Florida Dept Law Enforcement, Orlando, FL 32801 USA.
[Eckert-Lumsdon, Tiffany; Mooney, Kim] USA, Criminal Investigat Lab, Forest Pk, GA 30297 USA.
[Ernst, Troy] Michigan State Police Grand Rapids Lab, Grand Rapids, MI 49503 USA.
[Hanlon, Christopher] Forens Sci Serv Bur, Miami Dade Police Dept, Miami, FL 33172 USA.
[Heydon, Alex; Rudell, David] Ctr Forens Sci, Toronto, ON M7A 268, Canada.
[Nelson, Randall] Tennessee Bur Invest, Forens Serv Div, Nashville, TN 37216 USA.
[Olsson, Kristine] Johnson Cty Sheriffs Off Crime Lab, Sunset Olathe, KS 66061 USA.
[Palenik, Christopher] Microtrace LLC, Elgin, IL 60123 USA.
[Pollock, Edward Chip] Lab Forens Serv, Sacramento Cty Dist Attorneys Off, Sacramento, CA 95820 USA.
[Valadez, Melissa] Texas Dept, Publ Safety Crime Lab, Austin, TX 78752 USA.
[Almirall, Jose] Florida Int Univ, Dept Chem & Biochem, Miami, FL 33199 USA.
RP Almirall, J (reprint author), Florida Int Univ, Dept Chem & Biochem, OE116 11200 SW 8th St, Miami, FL 33199 USA.
EM almirall@fiu.edu
RI Almirall, Jose/D-1280-2010
OI Almirall, Jose/0000-0002-5257-7499
FU National Institute of Justice, Office of Justice Programs, U.S.
Department of Justice [2010-DN-BX-K179]
FX This project was supported by Award No. 2010-DN-BX-K179 from the
National Institute of Justice, Office of Justice Programs, U.S.
Department of Justice. The opinions, findings, and conclusions or
recommendations expressed in this presentation are those of the authors
and do not necessarily reflect those of the Department of Justice, the
Department of the Army or the Department of Defense. Thanks to all of
the Elemental Analysis Working Group members and their agencies for
devoting the time necessary to complete this project. This is
publication number 12-14 of the FBI Laboratory Division. Names of
commercial manufacturers are provided for identification purposes only,
and inclusion does not imply endorsement of the manufacturer, or its
products or services by the FBI. The views expressed are those of the
authors and do not necessarily reflect the official policy or position
of the FBI or the U.S. Government.
NR 54
TC 9
Z9 9
U1 8
U2 58
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1618-2642
J9 ANAL BIOANAL CHEM
JI Anal. Bioanal. Chem.
PD JUN
PY 2013
VL 405
IS 16
BP 5393
EP 5409
DI 10.1007/s00216-013-6978-y
PG 17
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA 155KD
UT WOS:000319745700005
PM 23673570
ER
PT J
AU Kuhn, JH
Bao, YM
Bavari, S
Becker, S
Bradfute, S
Brister, JR
Bukreyev, AA
Cai, YY
Chandran, K
Davey, RA
Dolnik, O
Dye, JM
Enterlein, S
Gonzalez, JP
Formenty, P
Freiberg, AN
Hensley, LE
Honko, AN
Ignatyev, GM
Jahrling, PB
Johnson, KM
Klenk, HD
Kobinger, G
Lackemeyer, MG
Leroy, EM
Lever, MS
Lofts, LL
Muhlberger, E
Netesov, SV
Olinger, GG
Palacios, G
Patterson, JL
Paweska, JT
Pitt, L
Radoshitzky, SR
Ryabchikova, EI
Saphire, EO
Shestopalov, AM
Smither, SJ
Sullivan, NJ
Swanepoel, R
Takada, A
Towner, JS
van der Groen, G
Volchkov, VE
Wahl-Jensen, V
Warren, TK
Warfield, KL
Weidmann, M
Nichol, ST
AF Kuhn, Jens H.
Bao, Yiming
Bavari, Sina
Becker, Stephan
Bradfute, Steven
Brister, J. Rodney
Bukreyev, Alexander A.
Cai, Yingyun
Chandran, Kartik
Davey, Robert A.
Dolnik, Olga
Dye, John M.
Enterlein, Sven
Gonzalez, Jean-Paul
Formenty, Pierre
Freiberg, Alexander N.
Hensley, Lisa E.
Honko, Anna N.
Ignatyev, Georgy M.
Jahrling, Peter B.
Johnson, Karl M.
Klenk, Hans-Dieter
Kobinger, Gary
Lackemeyer, Matthew G.
Leroy, Eric M.
Lever, Mark S.
Lofts, Loreen L.
Muehlberger, Elke
Netesov, Sergey V.
Olinger, Gene G.
Palacios, Gustavo
Patterson, Jean L.
Paweska, Janusz T.
Pitt, Louise
Radoshitzky, Sheli R.
Ryabchikova, Elena I.
Saphire, Erica Ollmann
Shestopalov, Aleksandr M.
Smither, Sophie J.
Sullivan, Nancy J.
Swanepoel, Robert
Takada, Ayato
Towner, Jonathan S.
van der Groen, Guido
Volchkov, Viktor E.
Wahl-Jensen, Victoria
Warren, Travis K.
Warfield, Kelly L.
Weidmann, Manfred
Nichol, Stuart T.
TI Virus nomenclature below the species level: a standardized nomenclature
for laboratory animal-adapted strains and variants of viruses assigned
to the family Filoviridae
SO ARCHIVES OF VIROLOGY
LA English
DT Article
ID VERVET MONKEY DISEASE; MARBURG VIRUS; EBOLA-VIRUS; RHABDOVIRUS-SIMIAE;
HEMORRHAGIC-FEVER; MOUSE MODEL; GUINEA-PIGS; VERO CELLS; INFECTION;
AGENT
AB The International Committee on Taxonomy of Viruses (ICTV) organizes the classification of viruses into taxa, but is not responsible for the nomenclature for taxa members. International experts groups, such as the ICTV Study Groups, recommend the classification and naming of viruses and their strains, variants, and isolates. The ICTV Filoviridae Study Group has recently introduced an updated classification and nomenclature for filoviruses. Subsequently, and together with numerous other filovirus experts, a consistent nomenclature for their natural genetic variants and isolates was developed that aims at simplifying the retrieval of sequence data from electronic databases. This is a first important step toward a viral genome annotation standard as sought by the US National Center for Biotechnology Information (NCBI). Here, this work is extended to include filoviruses obtained in the laboratory by artificial selection through passage in laboratory hosts. The previously developed template for natural filovirus genetic variant naming (< virus name > < isolation host-suffix >/< country of sampling >/< year of sampling >/< genetic variant designation >-< isolate designation >) is retained, but it is proposed to adapt the type of information added to each field for laboratory animal-adapted variants. For instance, the full-length designation of an Ebola virus Mayinga variant adapted at the State Research Center for Virology and Biotechnology "Vector" to cause disease in guinea pigs after seven passages would be akin to "Ebola virus VECTOR/C.porcellus-lab/COD/1976/Mayinga-GPA-P7". As was proposed for the names of natural filovirus variants, we suggest using the full-length designation in databases, as well as in the method section of publications. Shortened designations (such as "EBOV VECTOR/C.por/COD/76/May-GPA-P7") and abbreviations (such as "EBOV/May-GPA-P7") could be used in the remainder of the text depending on how critical it is to convey information contained in the full-length name. "EBOV" would suffice if only one EBOV strain/variant/isolate is addressed.
C1 [Kuhn, Jens H.; Cai, Yingyun; Jahrling, Peter B.; Lackemeyer, Matthew G.; Wahl-Jensen, Victoria] NIAID, Integrated Res Facil Ft Detrick IRF Frederick, DCR, NIH, Frederick, MD 21702 USA.
[Bao, Yiming; Brister, J. Rodney] Natl Lib Med, Informat Engn Branch, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA.
[Bavari, Sina; Dye, John M.; Honko, Anna N.; Lofts, Loreen L.; Olinger, Gene G.; Palacios, Gustavo; Pitt, Louise; Radoshitzky, Sheli R.; Warren, Travis K.] USA, Med Res Inst Infect Dis, Frederick, MD USA.
[Becker, Stephan; Dolnik, Olga; Klenk, Hans-Dieter] Univ Marburg, Inst Virol, D-35032 Marburg, Germany.
[Bradfute, Steven] Univ New Mexico, Albuquerque, NM 87131 USA.
[Bukreyev, Alexander A.; Freiberg, Alexander N.] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA.
[Bukreyev, Alexander A.; Freiberg, Alexander N.] Univ Texas Med Branch, Galveston Natl Lab, Galveston, TX 77555 USA.
[Chandran, Kartik] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA.
[Davey, Robert A.; Patterson, Jean L.] Texas Biomed Res Inst, Dept Virol & Immunol, San Antonio, TX USA.
[Enterlein, Sven; Warfield, Kelly L.] Integrated BioTherapeut Inc, Gaithersburg, MD USA.
[Gonzalez, Jean-Paul] Inst Rech Dev, Dept Hlth, Marseille, France.
[Gonzalez, Jean-Paul] Metabiota Inc, San Francisco, CA USA.
[Formenty, Pierre] World Hlth Org, Geneva, Switzerland.
[Hensley, Lisa E.] US FDA, Med Countermeasure Initiat, Silver Spring, MD USA.
[Ignatyev, Georgy M.] Fed State Unitary Co Microgen Sci Ind Co Immunobi, Minist Hlth & Social Dept Russian Federat, Moscow, Russia.
[Kobinger, Gary] Publ Hlth Agcy Canada, Special Pathogens Program, Natl Microbiol Lab, Winnipeg, MB, Canada.
[Leroy, Eric M.] Ctr Int Rech Med Franceville, Franceville, Gabon.
[Lever, Mark S.; Smither, Sophie J.] Dstl, Dept Biomed Sci, Salisbury, Wilts, England.
[Muehlberger, Elke] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA.
[Muehlberger, Elke] Boston Univ, Sch Med, Natl Emerging Infect Dis Lab, Boston, MA 02118 USA.
[Netesov, Sergey V.; Shestopalov, Aleksandr M.] Novosibirsk State Univ, Novosibirsk, Novosibirsk Obl, Russia.
[Paweska, Janusz T.] Natl Hlth Lab Serv, Ctr Emerging & Zoonot Dis, Natl Inst Communicable Dis, Sandringham Johannesburg, Gauteng, South Africa.
[Ryabchikova, Elena I.] Russian Acad Sci, Inst Chem Biol & Fundamental Med, Siberian Branch, Novosibirsk, Novosibirsk Obl, Russia.
[Saphire, Erica Ollmann] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA.
[Saphire, Erica Ollmann] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA.
[Shestopalov, Aleksandr M.] State Res Ctr Virol & Biotechnol Vector, Koltsov, Novosibirsk Obl, Russia.
[Sullivan, Nancy J.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
[Swanepoel, Robert] Univ Pretoria, Zoonoses Res Unit, ZA-0002 Pretoria, South Africa.
[Takada, Ayato] Hokkaido Univ, Div Global Epidemiol, Res Ctr Zoonosis Control, Sapporo, Hokkaido, Japan.
[Towner, Jonathan S.; Nichol, Stuart T.] Ctr Dis Control & Prevent CDC, VSPB, DHCPP, NCEZID, Atlanta, GA 30333 USA.
[van der Groen, Guido] Prins Leopold Inst Trop Geneeskunde, Antwerp, Belgium.
[Volchkov, Viktor E.] Univ Lyon, Lab Filovirus, Inserm U758, UCB Lyon 1,Ecole Normale Super Lyon, Lyon, France.
[Weidmann, Manfred] Univ Med Gottingen, Abt Virol, Gottingen, Germany.
RP Kuhn, JH (reprint author), NIAID, Integrated Res Facil Ft Detrick IRF Frederick, DCR, NIH, B-8200 Res Plaza, Frederick, MD 21702 USA.
EM kuhnjens@mail.nih.gov; stn1@cdc.gov
RI Ryabchikova, Elena /G-3089-2013; LEROY, Eric/I-4347-2016; Netesov,
Sergey/A-3751-2013; Volchkov, Viktor/M-7846-2014; Kuhn, Jens
H./B-7615-2011; Becker, Stephan/A-1065-2010; Palacios,
Gustavo/I-7773-2015; Weidmann, Manfred/G-1817-2015;
OI Gonzalez, Jean-Paul/0000-0003-3063-1770; Muhlberger,
Elke/0000-0003-3547-9376; Honko, Anna/0000-0001-9165-148X; Ryabchikova,
Elena /0000-0003-4714-1524; LEROY, Eric/0000-0003-0022-0890; Netesov,
Sergey/0000-0002-7786-2464; Volchkov, Viktor/0000-0001-7896-8706; Kuhn,
Jens H./0000-0002-7800-6045; Becker, Stephan/0000-0002-2794-5659;
Palacios, Gustavo/0000-0001-5062-1938; Weidmann,
Manfred/0000-0002-7063-7491; Shestopalov, Alexander/0000-0002-9734-0620;
Olinger, Gene/0000-0001-7338-0292
FU Joint Science and Technology Office for Chem Bio Defense
[TMTI0048_09_RD_T]; NIAID [HHSN272200200016I]; Intramural Research
Program of the NIH, National Library of Medicine
FX The content of this publication does not necessarily reflect the views
or policies of the US Department of the Army, the US Department of
Defense or the US Department of Health and Human Services or of the
institutions and companies affiliated with the authors. This work was
funded in part by the Joint Science and Technology Office for Chem Bio
Defense (proposal #TMTI0048_09_RD_T to SB). YC, JHK, and VWJ performed
this work as employees of Tunnell Consulting, Inc., and MGL as an
employee of Lovelace Respiratory Research Institute, both subcontractors
to Battelle Memorial Institute under its prime contract with NIAID,
under Contract No. HHSN272200200016I. This research was also supported
in part by the Intramural Research Program of the NIH, National Library
of Medicine (YB and JRB).
NR 42
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U2 23
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0304-8608
EI 1432-8798
J9 ARCH VIROL
JI Arch. Virol.
PD JUN
PY 2013
VL 158
IS 6
BP 1425
EP 1432
DI 10.1007/s00705-012-1594-2
PG 8
WC Virology
SC Virology
GA 155QK
UT WOS:000319762800035
PM 23358612
ER
PT J
AU Yee, SB
Dyer, DN
Twenhafel, NA
Pitt, MLM
AF Yee, Steven B.
Dyer, David N.
Twenhafel, Nancy A.
Pitt, M. Louise M.
TI Transient Lipopolysaccharide-Induced Resistance to Aerosolized Bacillus
anthracis in New Zealand White Rabbits
SO COMPARATIVE MEDICINE
LA English
DT Article
ID AFRICAN-GREEN MONKEY; INHALATIONAL ANTHRAX; BACTERIAL-INFECTION;
PROTECTIVE ANTIGEN; CYTOKINE RESPONSE; INNATE IMMUNITY; ANIMAL-MODELS;
MICE; ENDOTOXIN; SPORES
AB Previous studies have demonstrated that prior infection by various bacterial pathogens induces nonspecific resistance to subsequent infection by other gram-negative and gram-positive bacterial pathogens. In the present study, we evaluated whether underlying inflammation enhanced host resistance to inhalational Bacillus anthracis infection in New Zealand White rabbits (SPF; Bordetella- and Pasteurella-free). Accordingly, rabbits were pretreated with either the inflammagen bacterial LPS (60,000 EU/kg), a component of the outer membrane of gram-negative bacteria, or saline (vehicle). Administration of LPS resulted in brief pyrexia and a significant increase in the proinflammatory cytokine TNF alpha, thus confirming LPS-induced inflammation. At 24 h after LPS treatment, rabbits were exposed to aerosolized B. anthracis spores (Ames strain; approximately 300 LD50). Blood samples collected at various times after challenge were cultured. Compared with their saline-pretreated counterparts, LPS-pretreated, B. anthracis-challenged rabbits exhibited delays in 2 biomarkers of B. anthracis infection anthrax-induced pyrexia (25 h versus 66 h after challenge, respectively) and bacteremia (26 h versus 63 h, respectively)-and survived longer (41 h versus 90 h, respectively). Similar to control animals, all LPS-pretreated, B. anthracis-challenged rabbits exhibited pathology consistent with inhalational anthrax. Taken together, these results suggest that prior or underlying stimulation of the innate immune system induces transient host resistance to subsequent B. anthracis infection in SPF New Zealand white rabbits. In particular, our results emphasize the importance of using animals that are free of underlying infections to prevent confounding data in studies for inhalational anthrax characterization and medical countermeasure evaluation.
C1 [Yee, Steven B.; Dyer, David N.; Pitt, M. Louise M.] USA, Med Inst Infect Dis, Ctr Aerobiol Sci, Ft Detrick, MD USA.
[Twenhafel, Nancy A.] USA, Med Inst Infect Dis, Div Pathol, Ft Detrick, MD USA.
RP Yee, SB (reprint author), USA, Med Inst Infect Dis, Ctr Aerobiol Sci, Ft Detrick, MD USA.
EM steven.yee@us.army.mil
FU National Institute of Allergy and Infectious Diseases [Y1-AI-6129-04];
United States Army Medical Research Institute of Infectious Diseases
(USAMRIID) [A 120-B-10.3]
FX This research was sponsored through an interagency agreement between the
National Institute of Allergy and Infectious Diseases (Y1-AI-6129-04),
and the United States Army Medical Research Institute of Infectious
Diseases (USAMRIID; A 120-B-10.3). The views, opinions, and/or findings
contained herein are those of the authors and should not be construed as
an official Department of Army position, policy, or decision unless so
designated by other documentation. The authors do not have a commercial
or other association that would pose a conflict of interest.
NR 67
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U2 5
PU AMER ASSOC LABORATORY ANIMAL SCIENCE
PI MEMPHIS
PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA
SN 1532-0820
J9 COMPARATIVE MED
JI Comparative Med.
PD JUN
PY 2013
VL 63
IS 3
BP 252
EP 261
PG 10
WC Veterinary Sciences; Zoology
SC Veterinary Sciences; Zoology
GA 162WP
UT WOS:000320297000009
PM 23759528
ER
PT J
AU Basu, P
Gibbens, R
La Porta, T
Lin, CY
Swami, A
Yoneki, E
AF Basu, Prithwish
Gibbens, Richard
La Porta, Thomas
Lin, Ching-Yung
Swami, Ananthram
Yoneki, Eiko
TI Network Science
SO IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS
LA English
DT Editorial Material
C1 [Basu, Prithwish] Raytheon BBN Technol, Cambridge, MA USA.
[Gibbens, Richard] Univ Cambridge, Comp Lab, Cambridge CB2 3QG, England.
[La Porta, Thomas] Penn State Univ, State Coll, PA USA.
[Lin, Ching-Yung] IBM Res, Yorktown Hts, NY USA.
[Swami, Ananthram] USA, Res Lab, Adelphi, MD USA.
[Yoneki, Eiko] Univ Cambridge, Comp Lab, Syst Res Grp, Cambridge CB2 3QG, England.
RP Basu, P (reprint author), Raytheon BBN Technol, Cambridge, MA USA.
NR 0
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U1 0
U2 6
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0733-8716
J9 IEEE J SEL AREA COMM
JI IEEE J. Sel. Areas Commun.
PD JUN
PY 2013
VL 31
IS 6
BP 993
EP 996
DI 10.1109/JSAC.2013.130601
PG 4
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA 149XE
UT WOS:000319353900001
ER
PT J
AU Wang, D
Kaplan, L
Abdelzaher, T
Aggarwal, CC
AF Wang, Dong
Kaplan, Lance
Abdelzaher, Tarek
Aggarwal, Charu C.
TI On Credibility Estimation Tradeoffs in Assured Social Sensing
SO IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS
LA English
DT Article
DE Maximum Likelihood Estimation; Predictability; Cramer-Rao Lower Bound;
Scalability; Robustness; Truth Discovery; Social Sensing
AB Two goals of network science are to (i) uncover fundamental properties of phenomena modeled as networks, and to (ii) explore novel use of networks as models for a diverse range of systems and phenomena in order to improve our understanding of such systems and phenomena. This paper advances the latter direction by casting credibility estimation in social sensing applications as a network science problem, and by presenting a network model that helps understand the fundamental accuracy trade-offs of a credibility estimator. Social sensing refers to data collection scenarios, where observations are collected from (possibly unvetted) human sources. We call such observations claims to emphasize that we do not know whether or not they are factually correct. Predictable, scalable and robust estimation of both source reliability and claim correctness, given neither in advance, becomes a key challenge given the unvetted nature of sources and lack of means to verify their claims. In a previous conference publication, we proposed a maximum likelihood approach to jointly estimate both source reliability and claim correctness. We also derived confidence bounds to quantify the accuracy of such estimation. In this paper, we cast credibility estimation as a network science problem and offer systematic sensitivity analysis of the optimal estimator to understand its fundamental accuracy trade-offs as a function of an underlying network topology that describes key problem space parameters. It enables assured social sensing, where not only source reliability and claim correctness are estimated, but also the accuracy of such estimates is correctly predicted for the problem at hand.
C1 [Wang, Dong; Abdelzaher, Tarek] Univ Illinois, Dept Comp Sci, Urbana, IL 61801 USA.
[Kaplan, Lance] USA, Networked Sensing & Fus Branch, Res Lab, Adelphi, MD 20783 USA.
[Aggarwal, Charu C.] IBM Res, Yorktown Hts, NY 10598 USA.
RP Wang, D (reprint author), Univ Illinois, Dept Comp Sci, 1304 W Springfield Ave, Urbana, IL 61801 USA.
EM dwang24@illinois.edu; lance.m.kaplan@us.army.mil; za-her@illinois.edu;
charu@us.ibm.com
FU Army Research Laboratory, DTRA grant [HDTRA1-10-1-0120]; NSF [CNS
1040380, CNS 09-05014]
FX Research reported in this paper was sponsored by the Army Research
Laboratory, DTRA grant HDTRA1-10-1-0120, and NSF grants CNS 1040380 and
CNS 09-05014, and was accomplished under Cooperative Agreement Number
W911NF-09-2-0053. The views and conclusions contained in this document
are those of the authors and should not be interpreted as representing
the official policies, either expressed or implied, of the Army Research
Laboratory or the U.S. Government. The U.S. Government is authorized to
reproduce and distribute reprints for Government purposes
notwithstanding any copyright notation here on.
NR 22
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U1 0
U2 1
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0733-8716
J9 IEEE J SEL AREA COMM
JI IEEE J. Sel. Areas Commun.
PD JUN
PY 2013
VL 31
IS 6
BP 1026
EP 1037
DI 10.1109/JSAC.2013.130605
PG 12
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA 149XE
UT WOS:000319353900005
ER
PT J
AU Li, L
Scaglione, A
Swami, A
Zhao, Q
AF Li, Lin
Scaglione, Anna
Swami, Ananthram
Zhao, Qing
TI Consensus, Polarization and Clustering of Opinions in Social Networks
SO IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS
LA English
DT Article
DE opinion dynamics; continuous opinions; opinion clusters; consensus;
polarization; opinion formation; social networks; opinion diffusion;
information aggregation; network learning; non-Bayesian models;
information aggregation
AB We consider a variation of the Deffuant-Weisbuch model introduced by Deffuant et al. in 2000, to provide new analytical insights on the opinion dynamics in a social group. We model the trust that may exist between like-minded agents through a trust function, which is a discontinuous (hard-interaction) non-increasing function of the opinion distance. In this model, agents exchange their opinions with their neighbors and move their opinions closer to each other if they are like-minded (that is, the distance between opinions is smaller than a threshold). We first study the dynamics of opinion formation under random interactions with a fixed rate of communication between pairs of agents. Our goal is to analyze the convergence properties of the opinion dynamics and explore the underlying characteristics that mark the phase transition from opinion polarization to consensus. Furthermore, we extend the hard-interaction model to a strategic interaction model by considering a time-varying rate of interaction. In this model, social agents themselves decide the time and energy that should be expended on interacting each of their neighbors, based on their utility functions. The aim is to understand how and under what conditions clustering patterns emerge in opinion space. Extensive simulations are provided to validate the analytical results of both the hard-interaction model and the strategic interaction model. We also offer evidence that suggests the validity of the proposed model, using the location and monthly survey data collected in the Social Evolution experiment over a period of nine months.
C1 [Li, Lin; Scaglione, Anna; Zhao, Qing] Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95616 USA.
[Swami, Ananthram] USA, Res Lab, Adelphi, MD 20783 USA.
RP Li, L (reprint author), Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95616 USA.
EM llli@ucdavis.edu; ascaglione@ucdavis.edu; ananthram.swami.civ@mail.mil;
qzhao@ucdavis.edu
FU NSF [CCF-1011811]
FX The first two authors of this work were supported by NSF grant
CCF-1011811.
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U1 1
U2 23
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0733-8716
EI 1558-0008
J9 IEEE J SEL AREA COMM
JI IEEE J. Sel. Areas Commun.
PD JUN
PY 2013
VL 31
IS 6
BP 1072
EP 1083
DI 10.1109/JSAC.2013.130609
PG 12
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA 149XE
UT WOS:000319353900009
ER
PT J
AU Boonnak, K
Slike, BM
Donofrio, GC
Marovich, MA
AF Boonnak, Kobporn
Slike, Bonnie M.
Donofrio, Gina C.
Marovich, Mary A.
TI Human Fc gamma RII Cytoplasmic Domains Differentially Influence
Antibody-Mediated Dengue Virus Infection
SO JOURNAL OF IMMUNOLOGY
LA English
DT Article
ID HUMAN-IGG-FC; DEPENDENT ENHANCEMENT; HEMORRHAGIC-FEVER; DENDRITIC CELLS;
RECEPTORS; REGULATORS
AB Ab-dependent enhancement (ADE) of dengue virus (DENY) infection is mediated through the interaction of viral immune complexes with Fc gamma Rs, with notable efficiency of Fc gamma RII. Most human dengue target cells coexpress activating (Fc gamma RIIa) and inhibitory (Fc gamma RIIb) isoforms, but their relative roles in ADE are not well understood. We studied the effects of Fc gamma RIIa and Fc gamma RIIb by transfecting cells to express each individual receptor isoform or through coexpression of both isoforms. We showed that although both isoforms similarly bind dengue-immune complexes, Fc gamma RIIa efficiently internalized virus leading to productive cellular infection, unlike Fc gamma RIIb. We next focused on the main discriminating feature of these isoforms: their distinct intra-cytoplasmic tails (Fcy gamma IIa with an immunoreceptor tyrosine-based activation motif [ITAM] and Fc gamma RIIb with an immunoreceptor tyrosine-based inhibitory motif [ITIM]). We engineered cells to express "swapped" versions of their Fc gamma RII by switching the cytoplasmic tails containing the ITAM/ITIM motifs, leaving the remainder of the receptor intact. Our data show that both Fc gamma RIIa and Fc gamma RIIb comparably bind dengue immune complexes. However, wild type Fc gamma RIIa facilitates DENY entry by virtue of the ITAM motif, whereas the swapped version Fc gamma RIIa-ITIM significantly inhibited ADE. Similarly, replacing the inhibitory motif in Fc gamma RIIb with an ITAM (Fc gamma RIIb-ITAM) reconstituted ADE capacity to levels of the wild type activating counterpart, Fc gamma RIIa. Our data suggest that Fc gamma RIIa and Fc gamma RIIb isoforms, as the most abundantly distributed class II Fc gamma receptors, differentially influence Ab-mediated DENY infection under ADE conditions both at the level of cellular infection and viral production.
C1 [Boonnak, Kobporn; Slike, Bonnie M.; Donofrio, Gina C.; Marovich, Mary A.] Henry M Jackson Fdn Adv Mil Med, Walter Reed Army Inst Res, Rockville, MD 20850 USA.
[Marovich, Mary A.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA.
RP Marovich, MA (reprint author), NIAID, Vaccine Res Program, Div AIDS, NIH, 6700-B Rockledge Room 5142, Bethesda, MD 20892 USA.
EM mary.marovich@nih.gov
FU Pediatric Dengue Vaccine Initiative; Henry M. Jackson Foundation for the
Advancement of Military Medicine; U.S. Department of Defense
[W81XWH-07-2-0067]
FX This work was supported by the Pediatric Dengue Vaccine Initiative and
in part by the cooperative agreement (W81XWH-07-2-0067) between the
Henry M. Jackson Foundation for the Advancement of Military Medicine,
and the U.S. Department of Defense.
NR 31
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U2 5
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
J9 J IMMUNOL
JI J. Immunol.
PD JUN 1
PY 2013
VL 190
IS 11
BP 5659
EP 5665
DI 10.4049/j.immunol.1203052
PG 7
WC Immunology
SC Immunology
GA 147XY
UT WOS:000319205900036
PM 23616574
ER
PT J
AU Beyaz, MI
Hanrahan, BM
Feldman, J
Ghodssi, R
AF Beyaz, Mustafa Ilker
Hanrahan, Brendan Michael
Feldman, Jeremy
Ghodssi, Reza
TI An Integrated Permanent-Magnet Microturbogenerator Supported on
Microball Bearings
SO JOURNAL OF MICROELECTROMECHANICAL SYSTEMS
LA English
DT Article
DE Microball bearings; microgenerator; microturbogenerator; power
microelectromechanical systems (MEMS)
ID AXIAL-FLUX; POWER-GENERATION; DESIGN; FABRICATION; MICROSCALE; MACHINES
AB This paper presents the design, fabrication, and testing of an integrated microturbogenerator utilizing permanent magnets and microball bearings. The key components of this generator are the following: 1) a silicon microturbine rotor housing thick magnetic components; 2) encapsulated microball bearings providing a simple actuation scheme and a robust support structure; and 3) wafer-thick stator coils. The microturbogenerator was designed and fabricated to have a ten-pole rotor and a ten-pole three-turns-per-pole stator. The impedance of the stator coils was shown to be a purely resistive 220 Omega up to 10 kHz. The spin-down characterization of the rotor revealed a dynamic friction torque of 33 mu N . m at a rotational speed of 16 kilo rotations per minute (krpm), corresponding to 6% turbine efficiency. The maximum per-phase ac open-circuit voltage and power were measured to be 0.1 V and 5.6 mu W on a matched load at 23 krpm, respectively, in full agreement with theoretical analysis and performance estimations. The microturbogenerator presented in this paper provides a flexible design platform for further improvement and will lead to the development of next-generation integrated microturbogenerators offering high power, simple operation, and robust mechanics. [2012-0186]
C1 [Beyaz, Mustafa Ilker; Hanrahan, Brendan Michael; Feldman, Jeremy; Ghodssi, Reza] Univ Maryland, College Pk, MD 20742 USA.
[Hanrahan, Brendan Michael] USA, Res Lab, Adelphi, MD 20783 USA.
[Beyaz, Mustafa Ilker] Antalya Int Univ, TR-07190 Antalya, Turkey.
RP Beyaz, MI (reprint author), Antalya Int Univ, TR-07190 Antalya, Turkey.
EM mibeyaz@antalya.edu.tr; bhanrah@gmail.com; jfn@umd.edu; ghodssi@umd.edu
FU U.S. National Science Foundation [0901411]
FX This work was supported by the U.S. National Science Foundation under
Award 0901411. Subject Editor L. Spangler.
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U1 0
U2 17
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1057-7157
EI 1941-0158
J9 J MICROELECTROMECH S
JI J. Microelectromech. Syst.
PD JUN
PY 2013
VL 22
IS 3
BP 794
EP 803
DI 10.1109/JMEMS.2013.2245401
PG 10
WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology;
Instruments & Instrumentation; Physics, Applied
SC Engineering; Science & Technology - Other Topics; Instruments &
Instrumentation; Physics
GA 156MZ
UT WOS:000319827700031
ER
PT J
AU Marathe, AR
Taylor, DM
AF Marathe, A. R.
Taylor, D. M.
TI Decoding continuous limb movements from high-density epidural electrode
arrays using custom spatial filters
SO JOURNAL OF NEURAL ENGINEERING
LA English
DT Article
ID BRAIN-COMPUTER-INTERFACE; INDIVIDUAL FINGER MOVEMENTS;
SPINAL-CORD-INJURY; CHRONIC STROKE; MOTOR IMAGERY; ELECTROCORTICOGRAPHIC
SIGNALS; CORTICAL REPRESENTATION; HAND MOVEMENT; ARM MOVEMENTS;
REHABILITATION
AB Objective. Our goal was to identify spatial filtering methods that would improve decoding of continuous arm movements from epidural field potentials as well as demonstrate the use of the epidural signals in a closed-loop brain-machine interface (BMI) system in monkeys. Approach. Eleven spatial filtering options were compared offline using field potentials collected from 64-channel high-density epidural arrays in monkeys. Arrays were placed over arm/ hand motor cortex in which intracortical microelectrodes had previously been implanted and removed leaving focal cortical damage but no lasting motor deficits. Spatial filters tested included: no filtering, common average referencing (CAR), principle component analysis, and eight novel modifications of the common spatial pattern (CSP) algorithm. The spatial filtering method and decoder combination that performed the best offline was then used online where monkeys controlled cursor velocity using continuous wrist position decoded from epidural field potentials in real time. Main results. Optimized CSP methods improved continuous wrist position decoding accuracy by 69% over CAR and by 80% compared to no filtering. Kalman decoders performed better than linear regression decoders and benefitted from including more spatially-filtered signals but not from pre-smoothing the calculated power spectra. Conversely, linear regression decoders required fewer spatially-filtered signals and were improved by pre-smoothing the power values. The ` position-to-velocity' transformation used during online control enabled the animals to generate smooth closed-loop movement trajectories using the somewhat limited position information available in the epidural signals. The monkeys' online performance significantly improved across days of closed-loop training. Significance. Most published BMI studies that use electrocorticographic signals to decode continuous limb movements either use no spatial filtering or CAR. This study suggests a substantial improvement in decoding accuracy could be attained by using our new version of the CSP algorithm that extends the traditional CSP method for use with continuous limb movement data.
C1 [Marathe, A. R.; Taylor, D. M.] Cleveland Clin, Dept Neurosci, Cleveland, OH 44195 USA.
[Marathe, A. R.; Taylor, D. M.] Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA.
[Marathe, A. R.; Taylor, D. M.] Louis Stokes VA Med Ctr, Cleveland Funct Elect Stimulat FES Ctr Excellence, Cleveland, OH 44106 USA.
[Marathe, A. R.] USA, Human Res & Engn Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Marathe, AR (reprint author), Cleveland Clin, Dept Neurosci, Cleveland, OH 44195 USA.
EM dawn.taylor@case.edu
FU National Institutes of Health NINDS [1R01NS058871]; Department of
Veterans Affairs [B4195R]; Cleveland Clinic, and Case Western Reserve
University
FX This project was supported by the National Institutes of Health NINDS
1R01NS058871, the Department of Veterans Affairs # B4195R, the Cleveland
Clinic, and Case Western Reserve University.
NR 91
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U1 0
U2 12
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 1741-2560
EI 1741-2552
J9 J NEURAL ENG
JI J. Neural Eng.
PD JUN
PY 2013
VL 10
IS 3
AR 036015
DI 10.1088/1741-2560/10/3/036015
PG 16
WC Engineering, Biomedical; Neurosciences
SC Engineering; Neurosciences & Neurology
GA 152DM
UT WOS:000319510800018
PM 23611833
ER
PT J
AU Bourget, EC
Langsdale, SM
van den Belt, M
AF Bourget, Elizabeth C.
Langsdale, Stacy M.
van den Belt, Marjan
TI Featured Collection Introduction: Collaborative Modeling for Decision
Support as a Tool to Implement IWRM
SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION
LA English
DT Article
C1 [Bourget, Elizabeth C.] USA, Inst Water Resources, Corps Engineers, Alexandria, VA 22315 USA.
[Langsdale, Stacy M.] USA, Water Resources Collaborat, Inst Water Resources, Corps Engineers, Alexandria, VA 22315 USA.
[van den Belt, Marjan] Massey Univ, Palmerston North 4442, New Zealand.
[van den Belt, Marjan] Massey Univ, Ecol Econ Res New Zealand, Palmerston North 4442, New Zealand.
RP Bourget, EC (reprint author), USA, Inst Water Resources, Corps Engineers, 7701 Telegraph Rd, Alexandria, VA 22315 USA.
EM slangsdale@gmail.com
NR 10
TC 3
Z9 3
U1 0
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1093-474X
J9 J AM WATER RESOUR AS
JI J. Am. Water Resour. Assoc.
PD JUN
PY 2013
VL 49
IS 3
BP 605
EP 608
DI 10.1111/jawr.12071
PG 4
WC Engineering, Environmental; Geosciences, Multidisciplinary; Water
Resources
SC Engineering; Geology; Water Resources
GA 157LL
UT WOS:000319897500010
ER
PT J
AU Priscoli, JD
AF Priscoli, Jerome Delli
TI Keynote Address: Clothing the IWRM Emperor by Using Collaborative
Modeling for Decision Support
SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION
LA English
DT Article
C1 USA, Inst Water Resources, Corps Engineers, Alexandria, VA 22315 USA.
RP Priscoli, JD (reprint author), USA, Inst Water Resources, Corps Engineers, Casey Bldg,7701 Telegraph Rd, Alexandria, VA 22315 USA.
EM priscoli@erols.com
NR 0
TC 2
Z9 2
U1 0
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1093-474X
J9 J AM WATER RESOUR AS
JI J. Am. Water Resour. Assoc.
PD JUN
PY 2013
VL 49
IS 3
BP 609
EP 613
DI 10.1111/jawr.12072
PG 5
WC Engineering, Environmental; Geosciences, Multidisciplinary; Water
Resources
SC Engineering; Geology; Water Resources
GA 157LL
UT WOS:000319897500011
ER
PT J
AU Palmer, RN
Cardwell, HE
Lorie, MA
Werick, W
AF Palmer, Richard N.
Cardwell, Hal E.
Lorie, Mark A.
Werick, William
TI Disciplined Planning, Structured Participation, and Collaborative
Modeling - Applying Shared Vision Planning to Water Resources
SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION
LA English
DT Article
DE collaborative planning; collaborative modeling; systems models; water
management; water resources planning; adaptive management; participatory
methodologies
ID DECISION-MAKING; MANAGEMENT; DEMOCRACY; SCIENCE; POLICY
AB Participatory planning applied to water resources has sparked significant interest and debate during the last decade. Recognition that models play a significant role in the formulation and implementation of design and management strategies has encouraged the profession to consider how such models can be best implemented. Shared Vision Planning (SVP) is a disciplined planning approach that combines traditional water resources planning methodologies with innovations such as structured public participation and the use of collaborative modeling, resulting in a more complete understanding and an integrative decision support tool. This study reviews these three basic components of SVP and explains how they are incorporated into a unified planning approach. The successful application of SVP is explored in three studies involving planning challenges: the National Drought Study, the Lake Ontario-St. Lawrence River Study, and the Apalachicola-Chattahoochee-Flint/Alabama-Coosa-Tallapoosa River Basin Study. The article concludes by summarizing the advantages and limitations of this planning approach.
C1 [Palmer, Richard N.] Univ Massachusetts, Dept Civil & Environm Engn, Amherst, MA 01003 USA.
[Cardwell, Hal E.] USA, Conflict Resolut & Publ Participat Ctr, Inst Water Resources, Corps Engineers, Alexandria, VA 22315 USA.
[Lorie, Mark A.] Resolut Planning LLC, Ft Collins, CO 80526 USA.
[Werick, William] Werick Creat Solut, Culpeper, VA 22701 USA.
RP Palmer, RN (reprint author), Univ Massachusetts, Dept Civil & Environm Engn, 130 Nat Resources Rd, Amherst, MA 01003 USA.
EM palmer@esc.umass.edu
NR 77
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U1 0
U2 25
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1093-474X
J9 J AM WATER RESOUR AS
JI J. Am. Water Resour. Assoc.
PD JUN
PY 2013
VL 49
IS 3
BP 614
EP 628
DI 10.1111/jawr.12067
PG 15
WC Engineering, Environmental; Geosciences, Multidisciplinary; Water
Resources
SC Engineering; Geology; Water Resources
GA 157LL
UT WOS:000319897500012
ER
PT J
AU Langsdale, S
Beall, A
Bourget, E
Hagen, E
Kudlas, S
Palmer, R
Tate, D
Werick, W
AF Langsdale, Stacy
Beall, Allyson
Bourget, Elizabeth
Hagen, Erik
Kudlas, Scott
Palmer, Richard
Tate, Diane
Werick, William
TI Collaborative Modeling for Decision Support in Water Resources:
Principles and Best Practices
SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION
LA English
DT Article
DE collaborative modeling; decision support systems; public participation;
planning; participatory modeling; Shared Vision Planning; Mediated
Modeling; conflict resolution
AB Collaborative Modeling for Decision Support integrates collaborative modeling with participatory processes to inform natural resources decisions. Practitioners and advocates claim that the approach will lead to better water management, balancing interests more effectively and reducing the likelihood of costly legal delays. These claims are easy to make, but the benefits will only be realized if the process is conducted effectively. To provide guidance for how to conduct an effective collaborative modeling process, a task committee cosponsored by the Environmental Water Resources Institute (EWRI) of the American Society of Civil Engineers and by the U.S. Army Corps of Engineers' Institute for Water Resources developed a set of Principles and Best Practices for anyone who might convene or conduct collaborative modeling processes. The guidance is intended for both conflict resolution professionals and modelers, and our goal is to integrate these two fields in a way that will improve water resources planning and decision making. Here, the set of eight principles is presented along with a selection of associated best practices, illustrated by two different case examples. The complete document is available at: http://www.computeraideddisputeresolution.us/bestpractices/.
C1 [Langsdale, Stacy] USA, Water Resources Collaborat, Inst Water Resources, Corps Engineers, Alexandria, VA 22315 USA.
[Beall, Allyson] Washington State Univ, Pullman, WA 99164 USA.
[Bourget, Elizabeth] Inst Water Resources, Alexandria, VA 22315 USA.
[Hagen, Erik] Northeast Midwest Inst, Houston, TX 77019 USA.
[Hagen, Erik] Potamoi LLC, Houston, TX 77019 USA.
[Kudlas, Scott] Virginia Dept Environm Qual, Off Water Supply, Richmond, VA 23218 USA.
[Palmer, Richard] Univ Massachusetts, Dept Civil & Environm Engn, Amherst, MA 01003 USA.
[Werick, William] Werick Creat Solut Inc, Culpeper, VA 22701 USA.
RP Langsdale, S (reprint author), USA, Water Resources Collaborat, Inst Water Resources, Corps Engineers, 7701 Telegraph Rd, Alexandria, VA 22315 USA.
EM slangsdale@gmail.com
RI Palmer, Richard/K-4432-2013
OI Palmer, Richard/0000-0002-7338-0468
NR 15
TC 18
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U1 1
U2 26
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1093-474X
J9 J AM WATER RESOUR AS
JI J. Am. Water Resour. Assoc.
PD JUN
PY 2013
VL 49
IS 3
BP 629
EP 638
DI 10.1111/jawr.12065
PG 10
WC Engineering, Environmental; Geosciences, Multidisciplinary; Water
Resources
SC Engineering; Geology; Water Resources
GA 157LL
UT WOS:000319897500013
ER
PT J
AU Kaiser, L
Frins, E
Hils, B
Beresnev, L
Dultz, W
Schmitzer, H
AF Kaiser, Laure
Frins, Erna
Hils, Bernhard
Beresnev, Leonid
Dultz, Wolfgang
Schmitzer, Heidrun
TI Polarization analyzer for all the states of polarization of light using
a structured polarizer
SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND
VISION
LA English
DT Article
AB Polarization analyzers are an essential measuring tool to improve the characteristics of optical components and optimize them with respect to a useful application in optical networks. We describe an instrument of this kind, which consists of two crossed birefringent wedges and acts as a continuous structured polarizer for all the states of polarization of light. We analyze this device theoretically by using the Poincare-sphere and the Jones-matrix method and verify our results in a number of experiments with quartz wedges and red filtered light. Different realizations of this instrument are discussed, and an application as a beam splitter for all the states of polarization is proposed. (c) 2013 Optical Society of America
C1 [Kaiser, Laure; Schmitzer, Heidrun] Xavier Univ, Cincinnati, OH 45208 USA.
[Frins, Erna] Univ Republica, Inst Fis, Montevideo 11300, Uruguay.
[Hils, Bernhard; Dultz, Wolfgang] Johann Wolfgang von Goethe Univ, D-60054 Frankfurt, Germany.
[Beresnev, Leonid] USA, Res Lab, Columbia, MD 20783 USA.
RP Schmitzer, H (reprint author), Xavier Univ, Cincinnati, OH 45208 USA.
EM schmitzer@xavier.edu
FU Research Corporation for Science Advancement [CC6339]; John Hauck
Foundation; PEDECIBA (Uruguay); Comision Sectorial de Investigacion
Cientifica (CSIC, UdelaR, Uruguay)
FX This project was funded by grant CC6339 from the Research Corporation
for Science Advancement and the John Hauck Foundation. E. Frins
acknowledges the financial support from PEDECIBA (Uruguay) and the
Comision Sectorial de Investigacion Cientifica (CSIC, UdelaR, Uruguay).
The authors would like to thank A. Debell for the preparation of the
photos.
NR 13
TC 0
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U1 0
U2 9
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1084-7529
J9 J OPT SOC AM A
JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis.
PD JUN
PY 2013
VL 30
IS 6
BP 1256
EP 1260
DI 10.1364/JOSAA.30.001256
PG 5
WC Optics
SC Optics
GA 156DG
UT WOS:000319800400023
PM 24323113
ER
PT J
AU Jackson, WM
Alexander, PG
Bulken-Hoover, JD
Vogler, JA
Ji, YM
Mckay, P
Nesti, LJ
Tuan, RS
AF Jackson, Wesley M.
Alexander, Peter G.
Bulken-Hoover, Jamie D.
Vogler, Jared A.
Ji, Youngmi
McKay, Patricia
Nesti, Leon J.
Tuan, Rocky S.
TI Mesenchymal progenitor cells derived from traumatized muscle enhance
neurite growth
SO JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
LA English
DT Article
DE mesenchymal stem cells; nerve regeneration; neurotrophic factors; dorsal
root ganglia; brain-derived neurotrophic factor
ID PERIPHERAL-NERVE REGENERATION; STEM-CELLS; STROMAL CELLS; NEUROTROPHIC
FACTORS; CONDITIONED MEDIUM; NEURAL PROTEINS; TISSUE-REPAIR; IN-VITRO;
DIFFERENTIATION; EXPRESS
AB The success of peripheral nerve regeneration is governed by the rate and quality of axon bridging and myelination that occurs across the damaged region. Neurite growth and the migration of Schwann cells is regulated by neurotrophic factors produced as the nerve regenerates, and these processes can be enhanced by mesenchymal stem cells (MSCs), which also produce neurotrophic factors and other factors that improve functional tissue regeneration. Our laboratory has recently identified a population of mesenchymal progenitor cells (MPCs) that can be harvested from traumatized muscle tissue debrided and collected during orthopaedic reconstructive surgery. The objective of this study was to determine whether the traumatized muscle-derived MPCs exhibit neurotrophic function equivalent to that of bone marrow-derived MSCs. Similar gene- and protein-level expression of specific neurotrophic factors was observed for both cell types, and we localized neurogenic intracellular cell markers (brain-derived neurotrophic factor and nestin) to a subpopulation of both MPCs and MSCs. Furthermore, we demonstrated that the MPC-secreted factors were sufficient to enhance in vitro axon growth and cell migration in a chick embryonic dorsal root ganglia (DRG) model. Finally, DRGs in co-culture with the MPCs appeared to increase their neurotrophic function via soluble factor communication. Our findings suggest that the neurotrophic function of traumatized muscle-derived MPCs is substantially equivalent to that of the well-characterized population of bone marrow-derived MPCs, and suggest that the MPCs may be further developed as a cellular therapy to promote peripheral nerve regeneration. Copyright (c) 2012 John Wiley & Sons, Ltd.
C1 [Jackson, Wesley M.; Alexander, Peter G.; Bulken-Hoover, Jamie D.; Nesti, Leon J.; Tuan, Rocky S.] NIAMSD, Cartilage Biol & Orthopaed Branch, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA.
[Jackson, Wesley M.; McKay, Patricia; Nesti, Leon J.] Uniformed Serv Univ Hlth Sci, Dept Surg, Clin & Expt Orthopaed Lab, Bethesda, MD 20814 USA.
[Alexander, Peter G.; Tuan, Rocky S.] Univ Pittsburgh, Dept Orthopaed Surg, Sch Med, Ctr Cellular & Mol Engn, Pittsburgh, PA 15219 USA.
[Vogler, Jared A.; Ji, Youngmi; Nesti, Leon J.] NIAMSD, Clin & Expt Orthopaed Lab, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA.
[Bulken-Hoover, Jamie D.; Vogler, Jared A.; McKay, Patricia; Nesti, Leon J.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA.
RP Tuan, RS (reprint author), Univ Pittsburgh, Dept Orthopaed Surg, Sch Med, Ctr Cellular & Mol Engn, Room 221,450 Technol Dr, Pittsburgh, PA 15219 USA.
EM rst13@pitt.edu
FU National Institutes of Health (NIH) [Z01 AR41131]; Department of Defense
Military Amputee Research Program at WRAMC (Department of the Army, U.S.
Army Medical Research Acquisition Activity) [PO5-A011]; Comprehensive
Neurosciences Program (The Uniformed Services University of the Health
Sciences (USU) [CNP-2008-CR01]; Peer-reviewed Orthopedic Research
Program (Department of the Army, U.S. Army Medical Research Acquisition
Activity) [W81XWH-10-2-0084]; Commonwealth of Pennsylvania Department of
Health
FX This study was supported in part by the National Institutes of Health
(NIH) Intramural Research Program (Grant No. Z01 AR41131), the
Department of Defense Military Amputee Research Program at WRAMC
(Department of the Army, U.S. Army Medical Research Acquisition
Activity, 820 Chandler Street, Fort Detrick MD 217025014 is the awarding
and administering acquisition office, Grant No. PO5-A011), the
Comprehensive Neurosciences Program (The Uniformed Services University
of the Health Sciences (USU), 4301 Jones Bridge Rd. Bethesda, MD
20814-4799 is the awarding and administering office, Grant No.
CNP-2008-CR01) and the Peer-reviewed Orthopedic Research Program
(Department of the Army, U.S. Army Medical Research Acquisition
Activity, 820 Chandler Street, Fort Detrick MD 21702-5014 is the
awarding and administering acquisition office, Grant No.
W81XWH-10-2-0084), and from the Commonwealth of Pennsylvania Department
of Health. The authors thank Dr Paul Manner, University of Washington,
for providing human skeletal tissues, and Ibardo Zambrano and Richard
Booth for technical assistance.
NR 41
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U1 0
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1932-6254
J9 J TISSUE ENG REGEN M
JI J. Tissue Eng. Regen. Med.
PD JUN
PY 2013
VL 7
IS 6
BP 443
EP 451
DI 10.1002/term.539
PG 9
WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell
Biology; Engineering, Biomedical
SC Cell Biology; Biotechnology & Applied Microbiology; Engineering
GA 156OE
UT WOS:000319831100003
PM 22552971
ER
PT J
AU Phasomkusolsil, S
Tawong, J
Monkanna, N
Pantuwatana, K
Damdangdee, N
Khongtak, W
Kertmanee, Y
Evans, BP
Schuster, AL
AF Phasomkusolsil, Siriporn
Tawong, Jaruwan
Monkanna, Nantaporn
Pantuwatana, Kanchana
Damdangdee, Nuttapon
Khongtak, Weeraphan
Kertmanee, Yossasin
Evans, Brian P.
Schuster, Anthony L.
TI Maintenance of mosquito vectors: effects of blood source on feeding,
survival, fecundity, and egg hatching rates
SO JOURNAL OF VECTOR ECOLOGY
LA English
DT Article
DE Blood source; feeding; fecundity; Anopheles; Aedes
ID ANOPHELES-STEPHENSI; AEDES-ALBOPICTUS; CULICIDAE; DIPTERA; MEAL;
ALBIMANUS; MALARIA; SIZE
AB Artificial membrane-feeding techniques have replaced direct feeding on animals for the maintenance of malaria and arbovirus vectors in many laboratories. Membrane feeding facilitates controlled experimentation of pathogen transmission during mosquito feeding. Sheep blood is commonly used due to its availability and low cost. We evaluated the impact of blood source (human, guinea pig, sheep, and hamster via direct feeding) on feeding rates, adult survival, fecundity, hatching rates, and developmental times for five species of laboratory-colonized mosquitoes (Anopheles dirus, An. cracens, An. minimus, An. sawadwongporni, and Ae. aegypti). We found that feeding rates differ among blood sources within mosquito species. Survival, fecundity, and hatching rates were lower in all Anopheles species and Ae. aegypti after membrane feeding on sheep blood. Survival rates seven days post-feeding on sheep blood were significantly lower (P<0.05) for An. dirus (84.2%), An. minimus (67.2%), An. sawadwongporni (51.5%), and An. cracens (35.5%) relative to other blood sources. An. minimus and An. sawadwongporni laid no eggs by seven days post-feeding with sheep blood, while An. dirus and An. cracens produced significantly fewer numbers of eggs and demonstrated significantly lower hatching rates relative to what was observed with the other blood sources. These findings support the conclusion that sheep blood is not a suitable blood source for laboratory rearing of Anopheles spp.
C1 [Evans, Brian P.] Armed Forces Res Inst Med Sci, Dept Entomol, US Army Med Component, Bangkok 10400, Thailand.
US Army Publ Hlth Command Reg Pacific, Unit 45006, Apo, AP 96343, Japan.
EM siripornp@afrims.org
FU U.S. Army Medical and Material Command
FX Research was conducted in compliance with the Animal Welfare Act and
other federal statutes and regulations relating to animals and
experiments involving animals and adheres to principles stated in the
Guide for the Care and Use of Laboratory Animals, NRC Publication, 2011
edition. Funding for this project was partially provided by the U.S.
Army Medical and Material Command. The views expressed in this paper are
those of the authors and do not represent the position and/or reflect
the official policy of the Department of the Army, the Department of
Defense or the U.S. Government. We also wish to express our gratitude to
COL Chaiyaphruk Pilakasiri for reviewing and comments on the manuscript.
NR 19
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U2 29
PU SOC VECTOR ECOLOGY
PI CORONA
PA 1966 COMPTON AVE, CORONA, CA 92881 USA
SN 1081-1710
J9 J VECTOR ECOL
JI J. Vector Ecol.
PD JUN
PY 2013
VL 38
IS 1
BP 38
EP 45
DI 10.1111/j.1948-7134.2013.12006.x
PG 8
WC Entomology
SC Entomology
GA 150VX
UT WOS:000319420600005
PM 23701605
ER
PT J
AU Lutomiah, J
Bast, J
Clark, J
Richardson, J
Yalwala, S
Oullo, D
Mutisya, J
Mulwa, F
Musila, L
Khamadi, S
Schnabel, D
Wurapa, E
Sang, R
AF Lutomiah, Joel
Bast, Joshua
Clark, Jeffrey
Richardson, Jason
Yalwala, Santos
Oullo, David
Mutisya, James
Mulwa, Francis
Musila, Lillian
Khamadi, Samoel
Schnabel, David
Wurapa, Eyako
Sang, Rosemary
TI Abundance, diversity, and distribution of mosquito vectors in selected
ecological regions of Kenya: public health implications
SO JOURNAL OF VECTOR ECOLOGY
LA English
DT Article
DE Mosquito density; diversity; ecology; transmission
ID RIFT-VALLEY FEVER; WEST-NILE-VIRUS; AEDES-AEGYPTI; YELLOW-FEVER;
ENTOMOLOGIC INVESTIGATIONS; ARBOVIRAL INFECTIONS; SOUTH-AFRICA;
OUTBREAK; DIPTERA; SEROPREVALENCE
AB The diversity of mosquito arbovirus vectors was investigated to define regional risk of arbovirus transmission in Kenya. Mosquitoes were sampled between April, 2007 and December, 2010 at thirteen sites across seven administrative provinces and ecological zones. CDC light traps were used to collect mosquitoes while human-landing collection was conducted in five of the sites to target day-feeding Aedes (Stegomyia) species. Over 524,000 mosquitoes were collected and identified into 101 species, 30 of them known vectors of arboviruses endemic to Kenya. Ae. (Neomelaniconion) mcintoshi and Ae. (Aedimorphus) ochraceus were most abundant in Garissa in the arid northeastern province, and Mansonia uniformis and Mn. africana in semi-arid Baringo in the Rift Valley Province. Ae. ochraceus, Mn. africana and Mn. uniformis were also significant in Nyanza Province, while Ae. (Neomelaniconion) circumluteolus predominated in Budalangi, Western Province. Aedes (Stegomyia) aegypti was predominant in Rabai in the Coast Province but insignificant in the western and Nyanza sites. Culex pipiens was abundant in Rift Valley and Nyanza Provinces around the lake shores. This study highlights the potential for emergence and re-emergence of arboviral diseases among vulnerable populations. This calls for comprehensive mapping of vector distribution and abundance for planning focused vector control measures.
C1 [Lutomiah, Joel; Khamadi, Samoel; Sang, Rosemary] Kenya Med Res Inst KEMRI, Nairobi, Kenya.
[Bast, Joshua; Yalwala, Santos; Oullo, David] US Army Med Res Unit USAMRU K, Kisumu, Kenya.
[Lutomiah, Joel; Mutisya, James; Musila, Lillian; Wurapa, Eyako; Sang, Rosemary] US Army Med Res Unit USAMRU K, Nairobi, Kenya.
[Clark, Jeffrey] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Richardson, Jason; Schnabel, David] Walter Reed Army Inst Res, Silver Spring, MD USA.
RP Lutomiah, J (reprint author), Kenya Med Res Inst KEMRI, Nairobi, Kenya.
EM joel.lutomiah@usamru-k.org
RI Valle, Ruben/A-7512-2013
FU Department of Emerging Infectious Diseases (DEID); USAMRU-K; AFHSC
FX We thank Dunston Beti, John Gachoya, Reuben Lugalia, Daniel Ngonga, and
Anthony Mutai for their expert contribution in mosquito sampling and
identification. This project was fully supported by the Department of
Emerging Infectious Diseases (DEID), USAMRU-K, AFHSC. The content is
solely the views of the authors and does not represent the official
views of AFHSC.
NR 46
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U2 19
PU SOC VECTOR ECOLOGY
PI CORONA
PA 1966 COMPTON AVE, CORONA, CA 92881 USA
SN 1081-1710
J9 J VECTOR ECOL
JI J. Vector Ecol.
PD JUN
PY 2013
VL 38
IS 1
BP 134
EP 142
DI 10.1111/j.1948-7134.2013.12019.x
PG 9
WC Entomology
SC Entomology
GA 150VX
UT WOS:000319420600018
PM 23701618
ER
PT J
AU Klun, JA
Kramer, M
Debboun, M
AF Klun, Jerome A.
Kramer, Matthew
Debboun, Mustapha
TI Four simple stimuli that induce host-seeking and blood-feeding behaviors
in two mosquito species, with a clue to DEET's mode of action
SO JOURNAL OF VECTOR ECOLOGY
LA English
DT Article
DE Mosquito repellent; mosquito wind tunnel; ATP; water vapor; carbon
dioxide
ID HUMAN SKIN EMANATIONS; AEDES-AEGYPTI; CARBON-DIOXIDE; GORGING RESPONSE;
BIOASSAY SYSTEM; ATP ANALOGS; WIND-TUNNEL; CULICIDAE; DIPTERA;
IDENTIFICATION
AB Bioassays in a wind tunnel showed that a combination of four stimuli releases intense host-seeking and blood-feeding behavioral responses from females of the Asian tiger mosquito, Aedes albopictus, and the yellow fever mosquito, Aedes aegypti. The stimuli are carbon dioxide, water vapor, warmth, and adenosine triphosphate (ATP). Mosquitoes responded to this combination with a repertoire of blood-feeding behaviors that included upwind flight, landing, probing, and engorgement. Absence of carbon dioxide, water vapor, or ATP from the combination of stimuli or exposure to temperatures 12 degrees C below or above human-host temperature (38 degrees C) significantly attenuated blood-feeding behavior in both species. Although there is literature documenting the individual importance of each of these stimuli, our work represents the first instance where this combination of stimuli was found sufficient to elicit a complete repertoire of blood-feeding behaviors in these mosquitoes without involvement of any host specific odor. When mosquitoes were exposed to the four stimuli along with N,N-diethyl-3-methylbenzamide (DEET), feeding behavior was greatly suppressed. We hypothesize that a possible mode of action for DEET against these mosquitoes involves interference of warmth and/or water vapor receptors. An electrophysiological study designed to determine if DEET adversely affects the function of these receptors would be illuminating.
C1 [Klun, Jerome A.] ARS, USDA, Potomac, MD 20854 USA.
[Kramer, Matthew] ARS, USDA, Beltsville Agr Res Ctr, Beltsville, MD 20705 USA.
[Debboun, Mustapha] USA, Med Dept Ctr & Sch, Acad Hlth Sci, Dept Prevent Hlth Serv, Ft Sam Houston, TX 78234 USA.
RP Kramer, M (reprint author), ARS, USDA, Beltsville Agr Res Ctr, Beltsville, MD 20705 USA.
EM matt.kramer@ars.usda.gov
NR 40
TC 7
Z9 7
U1 3
U2 20
PU SOC VECTOR ECOLOGY
PI CORONA
PA 1966 COMPTON AVE, CORONA, CA 92881 USA
SN 1081-1710
J9 J VECTOR ECOL
JI J. Vector Ecol.
PD JUN
PY 2013
VL 38
IS 1
BP 143
EP 153
DI 10.1111/j.1948-7134.2013.12020.x
PG 11
WC Entomology
SC Entomology
GA 150VX
UT WOS:000319420600019
PM 23701619
ER
PT J
AU Vadera, S
Marathe, AR
Gonzalez-Martinez, J
Taylor, DM
AF Vadera, Sumeet
Marathe, Amar R.
Gonzalez-Martinez, Jorge
Taylor, Dawn M.
TI Stereoelectroencephalography for continuous two-dimensional cursor
control in a brain-machine interface
SO NEUROSURGICAL FOCUS
LA English
DT Article
DE stereoelectroencephalography; depth electrode; brain-machine interface;
brain-computer interface; epilepsy monitoring unit
ID MOVEMENT TRAJECTORIES; COMPUTER INTERFACES; FINGER MOVEMENTS; HUMANS;
TETRAPLEGIA; ECOG; ARM; ELECTRODES; SIGNALS; GRASP
AB Stereoelectroencephalography (SEEG) is becoming more prevalent as a planning tool for surgical treatment of intractable epilepsy. Stereoelectroencephalography uses long, thin, cylindrical "depth" electrodes containing multiple recording contacts along each electrode's length. Each lead is inserted into the brain percutaneously. The advantage of SEEG is that the electrodes can easily target deeper brain structures that are inaccessible with subdural grid electrodes, and SEEG does not require a craniotomy. Brain-machine interface (BMI) research is also becoming more common in the Epilepsy Monitoring Unit. A brain-machine interface decodes a person's desired movement or action from the recorded brain activity and then uses the decoded brain activity to control an assistive device in real time. Although BMIs are primarily being developed for use by severely paralyzed individuals, epilepsy patients undergoing invasive brain monitoring provide an opportunity to test the effectiveness of different invasive recording electrodes for use in BMI systems. This study investigated the ability to use SEEG electrodes for control of 2D cursor velocity in a BMI. Two patients who were undergoing SEEG for intractable epilepsy participated in this study. Participants were instructed to wiggle or rest the hand contralateral to their SEEG electrodes to control the horizontal velocity of a cursor on a screen. Simultaneously they were instructed to wiggle or rest their feet to control the vertical component of cursor velocity. The BMI system was designed to detect power spectral changes associated with hand and foot activity and translate those spectral changes into horizontal and vertical cursor movements in real time. During testing, participants used their decoded SEEG signals to move the brain-controlled cursor to radial targets that appeared on the screen. Although power spectral information from 28 to 32 electrode contacts were used for cursor control during the experiment, post hoc analysis indicated that better control may have been possible using only a single SEEG depth electrode containing multiple recording contacts in both hand and foot cortical areas. These results suggest that the advantages of using SEEG for epilepsy monitoring may also apply to using SEEG electrodes in BMI systems. Specifically, SEEG electrodes can target deeper brain structures, such as foot motor cortex, and both hand and foot areas can be targeted with a single SEEG electrode implanted percutaneously. Therefore, SEEG electrodes may be an attractive option for simple BMI systems that use power spectral modulation in hand and foot cortex for independent control of 2 degrees of freedom. (http://thejns.org/doi/abs/10.3171/2013.3.FOCUS1373)
C1 [Vadera, Sumeet; Gonzalez-Martinez, Jorge] Cleveland Clin, Dept Neurosurg, Cleveland, OH 44195 USA.
[Marathe, Amar R.; Taylor, Dawn M.] Cleveland Clin, Dept Neurosci, Cleveland, OH 44195 USA.
[Marathe, Amar R.; Taylor, Dawn M.] Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA.
[Marathe, Amar R.] Louis Stokes VA Med Ctr, Cleveland Funct Elect Stimulat FES Ctr Excellence, Cleveland, OH USA.
[Marathe, Amar R.; Taylor, Dawn M.] USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA.
RP Taylor, DM (reprint author), Cleveland Clin, Lerner Res Inst, 9500 Euclid Ave,NC30, Cleveland, OH 44195 USA.
EM dxt42@case.edu
FU National Institute of Neurological Disorders and Stroke, NIH
[R01-NS058871]; Department of Veterans Affairs (Merit Review) [B4195R];
Cleveland Clinic; Case Western Reserve University
FX This work was supported by the National Institute of Neurological
Disorders and Stroke, NIH (grant no. R01-NS058871), the Department of
Veterans Affairs (Merit Review no. B4195R), the Cleveland Clinic, and
Case Western Reserve University.
NR 36
TC 4
Z9 4
U1 2
U2 8
PU AMER ASSOC NEUROLOGICAL SURGEONS
PI ROLLING MEADOWS
PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA
SN 1092-0684
J9 NEUROSURG FOCUS
JI Neurosurg. Focus
PD JUN
PY 2013
VL 34
IS 6
AR E3
DI 10.3171/2013.3.FOCUS1373
PG 7
WC Clinical Neurology; Surgery
SC Neurosciences & Neurology; Surgery
GA 155HA
UT WOS:000319737400004
PM 23724837
ER
PT J
AU Mansi, I
Frei, CR
Pugh, MJ
Mortensen, EM
AF Mansi, Ishak
Frei, Christopher R.
Pugh, Mary J.
Mortensen, Eric M.
TI Psychologic Disorders and Statin Use: A Propensity Score-Matched
Analysis
SO PHARMACOTHERAPY
LA English
DT Article
DE statin; schizophrenia; depression; adverse events; psychological injury;
observational study
ID OF-THE-LITERATURE; DEPRESSIVE SYMPTOMS; OLDER PERSONS; CHOLESTEROL;
SIMVASTATIN; TRIAL; MOOD; ATORVASTATIN; VOLUNTEERS; DIAGNOSIS
AB Study Objective To evaluate the association between statin therapy and the risk of psychologic disorders including schizophrenia, psychosis, major depression, and bipolar disorder in a military population. Design Retrospective, observational, population-based, propensity score-matched, cohort study. Setting Database of a patient population enrolled in the San Antonio Military Multi-Market Area as Tricare Prime or Plus. Patients Medical records were reviewed from 46,249 patients aged 30-85years who were continuously enrolled in the San Antonio Military Multi-Market Area as Tricare Prime or Plus from October 1, 2003-March 1, 2010. Data were obtained from the Military Health System Management Analysis and Reporting Tool (M2). Based on drug fills during fiscal year 2005, patients were stratified as statin users (13,626 patients received at least 90-days supply of statin) or nonusers (32,623 patients never received a statin during the study period). A propensity score-matched cohort of 6972 statin users and 6972 nonusers from this population was created. Measurements and Main Results The occurrence of psychologic disorders between October 1, 2005, and March 1, 2010, was determined using prespecified groups of ICD-9-CM, Psych1: schizophrenia, schizoaffective disorders, and other psychosis; Psych2: major depression and bipolar disorder; Psych3: all psychologic disorders as identified by the Agency for Health Research and Quality-Clinical Classifications (except for categories of childhood or developmental psychiatric disorders). Between matched pairs of statin users and nonusers, the odds ratios and 95% confidence intervals were as follows: Psych1 (0.9, 0.75-1.05), Psych2 (1.02, 0.94-1.11), and Psych3 (1.02, 0.96-1.1), respectively. Conclusion The risk of developing psychologic disorders was similar in this cohort of propensity score-matched statin users and nonusers.
C1 [Mansi, Ishak] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
[Mansi, Ishak] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Mansi, Ishak; Pugh, Mary J.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
[Frei, Christopher R.] Univ Texas Austin, Coll Pharm, Austin, TX 78712 USA.
[Frei, Christopher R.] Univ Texas Hlth Sci Ctr San Antonio, Sch Med, Pharmacotherapy Educ & Res Ctr, San Antonio, TX 78229 USA.
[Mortensen, Eric M.] VA North Texas Hlth Care Syst, Dallas, TX 75216 USA.
[Mortensen, Eric M.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA.
RP Mansi, I (reprint author), VA North Texas Hlth Care Syst, Internal Med Serv, 4500 S Lancaster 111E, Dallas, TX 75216 USA.
EM ishak.mansi@va.gov
OI Mortensen, Eric/0000-0002-3880-5563
FU U.S. National Institutes of Health (NIH) [RR025766]; AstraZeneca;
Bristol Myers Squibb; Elan; Forest; Ortho-McNeil Janssen; Pfizer
FX CRF is supported by the U.S. National Institutes of Health (NIH) in the
form of a NIH/KL2 career development award (RR025766). In addition, CRF
has received research grants and/or served as a scientific
consultant/advisor for AstraZeneca, Bristol Myers Squibb, Elan, Forest,
Ortho-McNeil Janssen, and Pfizer.
NR 47
TC 13
Z9 13
U1 1
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0277-0008
J9 PHARMACOTHERAPY
JI Pharmacotherapy
PD JUN
PY 2013
VL 33
IS 6
BP 615
EP 626
DI 10.1002/phar.1272
PG 12
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 157DP
UT WOS:000319876300011
PM 23625731
ER
PT J
AU Markov, NP
Percival, TJ
Morrison, JJ
Ross, JD
Scott, DJ
Spencer, JR
Rasmussen, TE
AF Markov, Nickolay P.
Percival, Thomas J.
Morrison, Jonathan J.
Ross, James D.
Scott, Daniel J.
Spencer, Jerry R.
Rasmussen, Todd E.
TI Physiologic tolerance of descending thoracic aortic balloon occlusion in
a swine model of hemorrhagic shock
SO SURGERY
LA English
DT Article
ID EMERGENCY-DEPARTMENT THORACOTOMY; PORCINE MODEL; MANAGEMENT; TRAUMA; US
AB Background. Resuscitative endovascular balloon occlusion of the aorta (REBOA) is an emerging technique in trauma; however, the physiologic sequelae have not been well quantified. The objectives of this study were to characterize the burden of reperfusion and organ dysfunction of REBOA incurred during 30 or 90 min of class IV shock in a survivable porcine model of hemorrhage.
Methods. After induction of shock, animals were randomized into 4 groups (n = 6): 30 min of shock alone (30-Shock) or with REBOA (30-REBOA) and 90 min of shock alone (90-Shock) or with REBOA (90-REBOA). Cardiovascular homeostasis was then restored with blood, fluid, and vasapressors for 48 h. Outcomes included mean central aortic pressure (MCAP), lactate concentration, organ dysfunction, histologic evaluation, and resuscitation requirements.
Results. Both REBOA groups had greater MCAPs throughout their shock phase compared to controls (P < .05) but accumulated a significantly greater serum lactate burden, which returned to control levels by 150 min in the 30-REBOA groups and 320 min in the 90-REBOA group. There was a greater level of renal dysfunction and evidence of liver necrosis seen in the 90-REBOA group compared to the 90-Shock group. There was no evidence of cerebral or spinal cord necrosis in any group. The 90-RE130A group required more fluid resuscitation than the 90-Shock group (P = .05).
Conclusion. REBO4 in shock improves MCAP and is associated with a greater lactate burden; however, this lactate burden returned to control levels within the study period. Ultimately, prolonged REBOA is a survivable and potentially life-saving intervention in the setting of hemorrhagic shock and cardiovascular collapse in the pig.
C1 [Markov, Nickolay P.; Percival, Thomas J.; Morrison, Jonathan J.; Ross, James D.; Scott, Daniel J.; Spencer, Jerry R.; Rasmussen, Todd E.] Lackland AFB, Med Wing 59, Ft Sam Houston, TX USA.
[Markov, Nickolay P.; Percival, Thomas J.; Morrison, Jonathan J.; Scott, Daniel J.; Rasmussen, Todd E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Morrison, Jonathan J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England.
[Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA.
RP Rasmussen, TE (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM todd.rasmussen@amedd.army.mil
OI Morrison, Jonathan/0000-0001-7462-8456
FU US Air Force, Clinical Research Division, Lackland AF Base, San Antonio,
TX
FX Supported by the US Air Force, Clinical Research Division, Lackland AF
Base, San Antonio, TX.
NR 19
TC 34
Z9 34
U1 0
U2 0
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0039-6060
J9 SURGERY
JI Surgery
PD JUN
PY 2013
VL 153
IS 6
BP 848
EP 856
DI 10.1016/j.surg.2012.12.001
PG 9
WC Surgery
SC Surgery
GA 157JC
UT WOS:000319891400013
PM 23453327
ER
PT J
AU Ofula, VO
Franklin, AB
Root, JJ
Sullivan, HJ
Gichuki, P
Makio, A
Bulimo, W
Abong'o, BO
Muchai, M
Schnabel, D
AF Ofula, Victor O.
Franklin, Alan B.
Root, J. Jeffrey
Sullivan, Heather J.
Gichuki, Patrick
Makio, Albina
Bulimo, Wallace
Abong'o, Bernard O.
Muchai, Muchane
Schnabel, David
TI Detection of Avian Influenza Viruses in Wild Waterbirds in the Rift
Valley of Kenya Using Fecal Sampling
SO VECTOR-BORNE AND ZOONOTIC DISEASES
LA English
DT Article
DE Africa; Aves; Avian influenza virus; Feces; Nondomestic animals;
Waterfowl
ID H5N1 VIRUSES; A VIRUSES; BIRDS; AFRICA; SURVEILLANCE; PERSISTENCE;
HEMAGGLUTININ; EMERGENCE; WATERFOWL; PATTERNS
AB Highly pathogenic avian influenza virus A/H5N1 has been reported in 11 African countries. Migratory waterbirds have the potential of introducing A/H5N1 into east Africa through the Rift Valley of Kenya. We present the results of a wild bird surveillance system for A/H5N1 and other avian influenza viruses based on avian fecal sampling in Kenya. We collected 2630 fecal samples in 2008. Viral RNA was extracted from pools of 3-5 fecal samples and analyzed for presence of avian influenza virus RNA by real-time RT-PCR. Twelve (2.3%) of the 516 sample pools were positive for avian influenza virus RNA, 2 of which were subtyped as H4N6 viruses. This is the first report of avian influenza virus in wild birds in Kenya. This study demonstrates the success of this approach in detecting avian influenza virus in wild birds and represents an efficient surveillance system for avian influenza virus in regions with limited resources.
C1 [Ofula, Victor O.; Makio, Albina; Bulimo, Wallace; Schnabel, David] US Army Med Res Unit Kenya, Nairobi, Kenya.
[Franklin, Alan B.; Root, J. Jeffrey; Sullivan, Heather J.] Natl Wildlife Res Ctr, Ft Collins, CO USA.
[Gichuki, Patrick; Muchai, Muchane] Natl Museums Kenya, Nairobi, Kenya.
[Abong'o, Bernard O.] Great Lakes Univ Kisumu, Kisumu, Kenya.
RP Schnabel, D (reprint author), Walter Reed Army Inst Res, Div Prevent Med, 503 Robert Grant Rd, Silver Spring, MD 20910 USA.
EM david.c.schnabel@us.army.mil
RI Bulimo, Wallace/B-1982-2014
OI Bulimo, Wallace/0000-0001-8475-0586
FU U.S. Department of Defense, Armed Forces Health Surveillance Center,
Division of GEIS Operations
FX We would like to acknowledge Samuel Owaka for his assistance in sample
collections; Finley Osuna, Meshack Wadegu, Ben Kiawa, and Darcy Orahood
for assistance in laboratory testing; and Jeremy Ellis for his
assistance with map development. We would also like to thank Dr.
Rosemary Sang for providing laboratory space at the Kenya Medical
Research Institute, Centre for Virus Research, Nairobi, Kenya. Funding
for this work was provided by the U.S. Department of Defense, Armed
Forces Health Surveillance Center, Division of GEIS Operations.
NR 48
TC 0
Z9 0
U1 2
U2 14
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1530-3667
J9 VECTOR-BORNE ZOONOT
JI Vector-Borne Zoonotic Dis.
PD JUN
PY 2013
VL 13
IS 6
BP 394
EP 400
DI 10.1089/vbz.2011.0926
PG 7
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 157NV
UT WOS:000319905800008
PM 23621372
ER
PT J
AU Meeks, JJ
Walker, M
Bernstein, M
Eastham, JA
AF Meeks, Joshua J.
Walker, Marc
Bernstein, Melanie
Eastham, James A.
TI Seminal vesicle involvement at salvage radical prostatectomy
SO BJU INTERNATIONAL
LA English
DT Article
DE prostate cancer; radiation therapy; radical prostatectomy; seminal
vesicle invasion
ID LYMPH-NODE DISSECTION; RADIATION-THERAPY; CANCER; BIOPSY; IRRADIATION;
RADIOTHERAPY; IMPLANTATION; CARCINOMA; INVASION; OUTCOMES
AB Objective To describe the incidence and clinical outcomes of seminal vesicle invasion (SVI) at salvage radical prostatectomy (SRP) and to describe the accuracy of SV biopsy. As SRP is used after biochemical recurrence (BCR) of prostate cancer after radiotherapy (RT) to gain local oncological control. The SVs receive lower doses of radiation from external-beam RT (EBRT) to avoid rectal exposure and are not targeted with brachytherapy (BT) with low-risk prostate cancer.
Patients and Methods SRP was performed on 206 men with BCR after RT at a tertiary care institution between 1998 and 2011. Post-RT biopsy and SRP specimens were reviewed by a genitourinary pathologist.
Results SVI was detected in 65 (32%) of 206 patients. No difference was found between EBRT alone (65% vs 63%) and BT (29% vs 31%) with or without EBRT in patients with SVI. Men with SVI had higher rates of cT3 disease (20% vs 8%) and Gleason score 8 at SRP (52% vs 21%).
BCR-free survival at 5 years was 18% and 56% in patients with and without SVI (hazard ratio 2.85, 95% confidence interval 1.87-4.36, P < 0.001), yet the rate of local recurrence was low (11%).
Prostate cancer was identified in nine of 18 patients who underwent SV biopsy and was the only location of prostate cancer in two patients.
Conclusions SVI is a prognostic indicator for BCR after SRP, but local recurrence in patients with SVI after SRP remains low.
We recommend SV biopsy to improve staging and cancer detection in men with BCR after radiotherapy.
C1 [Meeks, Joshua J.; Bernstein, Melanie; Eastham, James A.] Mem Sloan Kettering Canc Ctr, Urol Serv, Dept Surg, New York, NY 10021 USA.
[Walker, Marc] Tripler Army Med Ctr, Dept Surg, Urol Serv, Honolulu, HI 96859 USA.
RP Eastham, JA (reprint author), Mem Sloan Kettering Canc Ctr, Urol Serv, Dept Surg, 353 East 68th St, New York, NY 10021 USA.
EM easthamj@mkscc.org
OI Bernstein, Melanie/0000-0002-0681-6188
NR 21
TC 1
Z9 1
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1464-4096
J9 BJU INT
JI BJU Int.
PD JUN
PY 2013
VL 111
IS 8
BP E342
EP E347
DI 10.1111/bju.12034
PG 6
WC Urology & Nephrology
SC Urology & Nephrology
GA 152GW
UT WOS:000319520800010
PM 23495695
ER
PT J
AU Thomas, AW
Garner, LE
Nevin, KP
Woodard, TL
Franks, AE
Lovley, DR
Sumner, JJ
Sund, CJ
Bazan, GC
AF Thomas, Alexander W.
Garner, Logan E.
Nevin, Kelly P.
Woodard, Trevor L.
Franks, Ashley E.
Lovley, Derek R.
Sumner, James J.
Sund, Christian J.
Bazan, Guillermo C.
TI A lipid membrane intercalating conjugated oligoelectrolyte enables
electrode driven succinate production in Shewanella
SO ENERGY & ENVIRONMENTAL SCIENCE
LA English
DT Article
ID MICROBIAL FUEL-CELLS; REDUCED NEUTRAL RED; GEOBACTER-SULFURREDUCENS;
BACTERIA; ELECTRICITY; MR-1; PERFORMANCE; REDUCTION; NETWORKS; BIOFILMS
AB An amphiphilic conjugated oligoelectrolyte (COE) that spontaneously intercalates into lipid membranes enables Shewanella oneidensis to use a graphite electrode as the sole electron donor for succinate production. Current consumed in a poised electrochemical system by Shewanella with micromolar concentrations of COE correlates well with the succinate produced via fumarate reduction as determined by HPLC analysis. Confocal microscopy confirms incorporation of the COE into the microbes on the electrode surface. This work presents a unique strategy to induce favorable bio-electronic interactions for the production of reduced microbial metabolites.
C1 [Thomas, Alexander W.; Garner, Logan E.; Bazan, Guillermo C.] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA.
[Nevin, Kelly P.; Woodard, Trevor L.; Franks, Ashley E.; Lovley, Derek R.] Univ Massachusetts, Dept Microbiol, Amherst, MA 01003 USA.
[Franks, Ashley E.] La Trobe Univ, Dept Microbiol, Bundoora, Vic 3086, Australia.
[Sumner, James J.; Sund, Christian J.] USA, Sensors & Elect Devices Directorate, Res Lab, Adelphi, MD 20783 USA.
RP Thomas, AW (reprint author), Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA.
EM bazan@chem.ucsb.edu
RI Bazan, Guillermo/B-7625-2014
FU Institute for Collaborative Biotechnologies [W91NF-09-0001]; Advanced
Research Projects Agency-Energy (ARPA-E), U.S. Department of Energy
[DE-AR0000159]
FX The authors thank the Institute for Collaborative Biotechnologies
(W91NF-09-0001), and award no. DE-AR0000159 from the Advanced Research
Projects Agency-Energy (ARPA-E), U.S. Department of Energy to DRL for
financial support.
NR 48
TC 28
Z9 28
U1 1
U2 80
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1754-5692
J9 ENERG ENVIRON SCI
JI Energy Environ. Sci.
PD JUN
PY 2013
VL 6
IS 6
BP 1761
EP 1765
DI 10.1039/c3ee00071k
PG 5
WC Chemistry, Multidisciplinary; Energy & Fuels; Engineering, Chemical;
Environmental Sciences
SC Chemistry; Energy & Fuels; Engineering; Environmental Sciences & Ecology
GA 148YF
UT WOS:000319284200009
ER
PT J
AU Rajanna, C
Ouellette, G
Rashid, M
Zemla, A
Karavis, M
Zhou, C
Revazishvili, T
Redmond, B
McNew, L
Bakanidze, L
Imnadze, P
Rivers, B
Skowronski, EW
O'Connell, KP
Sulakvelidze, A
Gibbons, HS
AF Rajanna, Chythanya
Ouellette, Gary
Rashid, Mohammed
Zemla, Adam
Karavis, Mark
Zhou, Carol
Revazishvili, Tamara
Redmond, Brady
McNew, Lauren
Bakanidze, Lela
Imnadze, Paata
Rivers, Bryan
Skowronski, Evan W.
O'Connell, Kevin P.
Sulakvelidze, Alexander
Gibbons, Henry S.
TI A strain of Yersinia pestis with a mutator phenotype from the Republic
of Georgia
SO FEMS MICROBIOLOGY LETTERS
LA English
DT Article
DE Yersinia pestis; mutator; DNA repair; mutS; evolution
ID TEMPERATURE-DEPENDENT VARIATIONS; COMPLETE GENOME SEQUENCE;
ESCHERICHIA-COLI; BACTERIAL-POPULATIONS; PHYLOGENETIC ANALYSIS; TANDEM
REPEATS; MUTS GENE; PLAGUE; EVOLUTION; RATES
AB We describe here a strain of Yersinia pestis, G1670A, which exhibits a baseline mutation rate elevated 250-fold over wild-type Y.pestis. The responsible mutation, a C to T substitution in the mutS gene, results in the transition of a highly conserved leucine at position 689 to arginine (mutS(L689R)). When the MutSL689R protein of G1670A was expressed in a mutS derivative of Y.pestis strain EV76, mutation rates observed were equivalent to those observed in G1670A, consistent with a causal association between the mutS mutation and the mutator phenotype. The observation of a mutator allele in Yersinia pestis has potential implications for the study of evolution of this and other especially dangerous pathogens.
C1 [Rajanna, Chythanya; Rashid, Mohammed; Revazishvili, Tamara; Sulakvelidze, Alexander] Univ Florida, Emerging Pathogens Inst, Gainesville, FL USA.
[Ouellette, Gary; Karavis, Mark; Redmond, Brady; McNew, Lauren; Rivers, Bryan; Skowronski, Evan W.; O'Connell, Kevin P.; Gibbons, Henry S.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
[Ouellette, Gary] Sci Applicat Int Inc, Aberdeen Proving Ground, MD USA.
[Zemla, Adam; Zhou, Carol] Lawrence Livermore Natl Lab, Livermore, CA USA.
[Bakanidze, Lela; Imnadze, Paata] Natl Ctr Dis Control, Tbilisi, Rep of Georgia.
RP Gibbons, HS (reprint author), USA, Edgewood Chem Biol Ctr, RDCB DRB M, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
EM henry.s.gibbons.civ@mail.mil
NR 36
TC 3
Z9 3
U1 0
U2 12
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0378-1097
EI 1574-6968
J9 FEMS MICROBIOL LETT
JI FEMS Microbiol. Lett.
PD JUN
PY 2013
VL 343
IS 2
BP 113
EP 120
DI 10.1111/1574-6968.12137
PG 8
WC Microbiology
SC Microbiology
GA 152ET
UT WOS:000319514300002
PM 23521061
ER
PT J
AU McGann, P
Milillo, M
Clifford, RJ
Snesrud, E
Stevenson, L
Backlund, MG
Viscount, HB
Quintero, R
Kwak, YI
Zapor, MJ
Waterman, PE
Lesho, EP
AF McGann, Patrick
Milillo, Michael
Clifford, Robert J.
Snesrud, Erik
Stevenson, Lindsay
Backlund, Michael G.
Viscount, Helen B.
Quintero, Reyes
Kwak, Yoon I.
Zapor, Michael J.
Waterman, Paige E.
Lesho, Emil P.
TI Detection of New Delhi Metallo-beta-Lactamase (Encoded by bla(NDM-1)) in
Acinetobacter schindleri during Routine Surveillance
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID EMERGING CARBAPENEMASES; MULTIDRUG-RESISTANCE; IDENTIFICATION;
BAUMANNII; URSINGII; PLASMID; PCR
AB A carbapenem-resistant Alcaligenes faecalis strain was isolated from a surveillance swab of a service member injured in Afghanistan. The isolate was positive for bla(NDM) by real-time PCR. Species identification was reevaluated on three identification systems but was inconclusive. Genome sequencing indicated that the closest relative was Acinetobacter schindleri and that bla(NDM-1) was carried on a plasmid that shared >99% identity with one identified in an Acinetobacter lwoffii isolate. The isolate also carried a novel chromosomally encoded class D oxacillinase.
C1 [McGann, Patrick; Milillo, Michael; Clifford, Robert J.; Snesrud, Erik; Quintero, Reyes; Kwak, Yoon I.; Waterman, Paige E.; Lesho, Emil P.] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA.
[Stevenson, Lindsay; Backlund, Michael G.; Viscount, Helen B.] Walter Reed Natl Mil Med Ctr, Dept Pathol, Bethesda, MD USA.
[Zapor, Michael J.] Walter Reed Natl Mil Med Ctr, Infect Dis Serv, Bethesda, MD USA.
RP McGann, P (reprint author), Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA.
EM patrick.t.mcgann4.ctr@mail.mil
FU Global Emerging Infections Surveillance and Response System (GEIS)
[C070912WR]; Defense Medical Research and Development Program (DMRDP)
[D61I10J258]
FX Major funding for this project was provided by the Global Emerging
Infections Surveillance and Response System (GEIS; grant number
C070912WR) and Defense Medical Research and Development Program (DMRDP;
grant number D61I10J258).
NR 19
TC 9
Z9 10
U1 0
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD JUN
PY 2013
VL 51
IS 6
BP 1942
EP 1944
DI 10.1128/JCM.00281-13
PG 3
WC Microbiology
SC Microbiology
GA 147VV
UT WOS:000319197800048
PM 23554204
ER
PT J
AU Ji, SY
Belle, A
Ward, KR
Ryan, KL
Rickards, CA
Convertino, VA
Najarian, K
AF Ji, Soo-Yeon
Belle, Ashwin
Ward, Kevin R.
Ryan, Kathy L.
Rickards, Caroline A.
Convertino, Victor A.
Najarian, Kayvan
TI Heart rate variability analysis during central hypovolemia using wavelet
transformation
SO JOURNAL OF CLINICAL MONITORING AND COMPUTING
LA English
DT Article
DE Heart rate variability (HRV); RR interval; Discrete wavelet
transformation; Power spectral density; Higuchi fractal dimension; Lower
body negative pressure (LBNP)
ID BODY NEGATIVE-PRESSURE; FRACTAL DIMENSION; TRAUMA PATIENTS; PERIOD
VARIABILITY; AUTONOMIC FUNCTION; HEMORRHAGIC-SHOCK; SPECTRAL-ANALYSIS;
TIME-SERIES; COMPLEXITY; MORTALITY
AB Detection of hypovolemia prior to overt hemodynamic decompensation remains an elusive goal in the treatment of critically injured patients in both civilian and combat settings. Monitoring of heart rate variability has been advocated as a potential means to monitor the rapid changes in the physiological state of hemorrhaging patients, with the most popular methods involving calculation of the R-R interval signal's power spectral density (PSD) or use of fractal dimensions (FD). However, the latter method poses technical challenges, while the former is best suited to stationary signals rather than the non-stationary R-R interval. Both approaches are also limited by high inter- and intra-individual variability, a serious issue when applying these indices to the clinical setting. We propose an approach which applies the discrete wavelet transform (DWT) to the R-R interval signal to extract information at both 500 and 125 Hz sampling rates. The utility of machine learning models based on these features were tested in assessing electrocardiogram signals from volunteers subjected to lower body negative pressure induced central hypovolemia as a surrogate of hemorrhage. These machine learning models based on DWT features were compared against those based on the traditional PSD and FD, at both sampling rates and their performance was evaluated based on leave-one-subject-out fold cross-validation. Results demonstrate that the proposed DWT-based model outperforms individual PSD and FD methods as well as the combination of these two traditional methods at both sample rates of 500 Hz (p value < 0.0001) and 125 Hz (p value < 0.0001) in detecting the degree of hypovolemia. These findings indicate the potential of the proposed DWT approach in monitoring the physiological changes caused by hemorrhage. The speed and relatively low computational costs in deriving these features may make it particularly suited for implementation in portable devices for remote monitoring.
C1 [Ji, Soo-Yeon] Bowie State Univ, Bowie, MD USA.
[Belle, Ashwin; Najarian, Kayvan] Virginia Commonwealth Univ, Richmond, VA 23284 USA.
[Ward, Kevin R.] Univ Michigan Hlth Syst, Ann Arbor, MI USA.
[Ryan, Kathy L.; Convertino, Victor A.] USA, Inst Surg Res USISR, Ft Sam Houston, TX USA.
[Rickards, Caroline A.] Univ North Texas Hlth Sci Ctr, Ft Worth, TX USA.
RP Najarian, K (reprint author), Virginia Commonwealth Univ, Richmond, VA 23284 USA.
EM knajarian@vcu.edu
OI Belle, Ashwin/0000-0002-8084-3563
FU National Science Foundation [IIS0758410]; U.S. Army Medical Research and
Material Command Combat Casualty Care Research Program [05-0033-02]
FX This material is based upon work supported by the National Science
Foundation under Grant No. IIS0758410 and by the U.S. Army Medical
Research and Material Command Combat Casualty Care Research Program
(Grant: 05-0033-02). The opinions expressed herein are the personal
opinions of the authors and are not to be construed as representing
those of the Department of Defense, the Department of the Army, or the
United States Army.
NR 49
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Z9 6
U1 1
U2 12
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1387-1307
J9 J CLIN MONIT COMPUT
JI J. Clin. Monitor. Comp.
PD JUN
PY 2013
VL 27
IS 3
BP 289
EP 302
DI 10.1007/s10877-013-9434-9
PG 14
WC Anesthesiology
SC Anesthesiology
GA 146DW
UT WOS:000319070600012
PM 23371800
ER
PT J
AU Champagne, V
Helfritch, D
Wienhold, E
DeHaven, J
AF Champagne, Victor
Helfritch, Dennis
Wienhold, Erik
DeHaven, Jennifer
TI Deposition of copper micro-circuitry by capillary focusing
SO JOURNAL OF MICROMECHANICS AND MICROENGINEERING
LA English
DT Article
AB The application of fine line micro-circuitry onto ceramic substrates currently requires a multi step process including printing, baking and sintering. A new, one-step, process utilizing particle impact deposition is presented. This process directs a high velocity stream of copper particles within a helium carrier onto a ceramic substrate. Upon impact the particles deform and adhere to the substrate and to previously deposited particles. The use of a capillary tube as the flow nozzle restricts the jet and the resulting deposited copper to micron scale dimensions. The deposited copper is dense, with near zero porosity. Robot control of the jet position can yield precise conduction lines and component connections.
C1 [Champagne, Victor] USA, Res Lab, Aberdeen Proving Ground, MD USA.
[Helfritch, Dennis] Dynam Sci Inc, Aberdeen, MD USA.
[Wienhold, Erik] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA.
[DeHaven, Jennifer] Missouri Univ Sci & Technol, Dept Mat Sci & Engn, Rolla, MO USA.
RP Champagne, V (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD USA.
EM victor.k.champagne.civ@mail.mil
NR 8
TC 3
Z9 3
U1 1
U2 10
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0960-1317
J9 J MICROMECH MICROENG
JI J. Micromech. Microeng.
PD JUN
PY 2013
VL 23
IS 6
AR 065023
DI 10.1088/0960-1317/23/6/065023
PG 6
WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology;
Instruments & Instrumentation; Physics, Applied
SC Engineering; Science & Technology - Other Topics; Instruments &
Instrumentation; Physics
GA 151HM
UT WOS:000319451300023
ER
PT J
AU Hergert, RJ
Hanrahan, B
Ghodssi, R
Holmes, AS
AF Hergert, Robert J.
Hanrahan, Brendan
Ghodssi, Reza
Holmes, Andrew S.
TI Performance of integrated retainer rings in silicon micro-turbines with
thrust style micro-ball bearings
SO JOURNAL OF MICROMECHANICS AND MICROENGINEERING
LA English
DT Article
ID MEMS
AB This work explores the performance of different silicon retainer ring designs when integrated into silicon micro-turbines (SMTs) incorporating thrust style bearings supported on 500 mu m diameter steel balls. Experimental performance curves are presented for SMTs with rotor diameters of 5 mm and 10 mm, each with five different retainer designs varying in mechanical rigidity, ball pocket shape and ball complement. It was found that the different retainer designs yielded different performance curves, with the closed pocket designs consistently requiring lower input power for a given rotation speed, and the most rigid retainers giving the best performance overall. Both 5 mm and 10 mm diameter devices have shown repeatable performance at rotation speeds up to and exceeding 20 000 RPM with input power levels below 2 W, and devices were tested for over 2.5 million revolutions without failure. Retainer rings are commonly used in macro-scale bearings to ensure uniform spacing between the rolling elements. The integration of retainers into micro-bearings could lower costs by reducing the number of balls required for stable operation, and also open up the possibility of 'smart' bearings with integrated sensors to monitor the bearing status.
C1 [Hergert, Robert J.; Holmes, Andrew S.] Univ London Imperial Coll Sci Technol & Med, Dept Elect & Elect Engn, London SW7 2AZ, England.
[Hanrahan, Brendan; Ghodssi, Reza] Univ Maryland, Dept Elect Engn, College Pk, MD 20742 USA.
[Hanrahan, Brendan] USA, Res Lab, Adelphi, MD USA.
RP Holmes, AS (reprint author), Univ London Imperial Coll Sci Technol & Med, Dept Elect & Elect Engn, Exhibit Rd, London SW7 2AZ, England.
EM a.holmes@imperial.ac.uk
NR 21
TC 3
Z9 3
U1 0
U2 8
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0960-1317
EI 1361-6439
J9 J MICROMECH MICROENG
JI J. Micromech. Microeng.
PD JUN
PY 2013
VL 23
IS 6
AR 065033
DI 10.1088/0960-1317/23/6/065033
PG 11
WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology;
Instruments & Instrumentation; Physics, Applied
SC Engineering; Science & Technology - Other Topics; Instruments &
Instrumentation; Physics
GA 151HM
UT WOS:000319451300033
ER
PT J
AU Lazarus, N
Meyer, CD
Bedair, SS
Song, X
Boteler, LM
Kierzewski, IM
AF Lazarus, N.
Meyer, C. D.
Bedair, S. S.
Song, X.
Boteler, L. M.
Kierzewski, I. M.
TI Thick film oxidation of copper in an electroplated MEMS process
SO JOURNAL OF MICROMECHANICS AND MICROENGINEERING
LA English
DT Article
ID OXIDE FILMS; WAFER; CU; BEHAVIOR
AB Copper forms a porous oxide, allowing the formation of oxide layers up to tens of microns thick to be created at modest processing temperatures. In this work, the controlled oxidation of copper is employed within an all-metal electroplating process to create electrically insulating, structural posts and beams. This capability could eliminate the additional dielectric deposition and patterning steps that are often needed during the construction of sensors, waveguides, and other microfabricated devices. In this paper, copper oxidation rates for thermal and plasma-assisted growth methods are characterized. Time control of the oxide growth enables larger copper structures to remain conductive while smaller copper posts are fully oxidized. The concept is demonstrated using the controlled oxidation of a copper layer between two nickel layers to fabricate nickel inductors having both copper electrical vias and copper oxide support pillars. Nickel was utilized in this demonstration for its resistance against low temperature oxidation and interdiffusion with copper.
C1 [Lazarus, N.] USA, Res Lab, Oak Ridge Associated Univ Fellowship Program, Adelphi, MD 20783 USA.
[Meyer, C. D.; Bedair, S. S.; Boteler, L. M.; Kierzewski, I. M.] USA, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA.
[Song, X.] W Virginia Univ, Dept Mech & Aerosp Engn, Morgantown, WV 26506 USA.
RP Lazarus, N (reprint author), USA, Res Lab, Oak Ridge Associated Univ Fellowship Program, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM nathan.lazarus2.ctr@mail.mil
FU Army Research Laboratory [W911NF-12-2-0019]
FX This work was sponsored by the Army Research Laboratory and was
accomplished under Cooperative Agreement Number W911NF-12-2-0019. The
views and conclusions contained in this document are those of the
authors and should not be interpreted as representing the official
policies, either expressed or implied, of the Army Research Laboratory
or the US Government. The US Government is authorized to reproduce and
distribute reprints for Government purposes notwithstanding any
copyright notation herein.
NR 38
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U1 3
U2 24
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0960-1317
J9 J MICROMECH MICROENG
JI J. Micromech. Microeng.
PD JUN
PY 2013
VL 23
IS 6
AR 065017
DI 10.1088/0960-1317/23/6/065017
PG 9
WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology;
Instruments & Instrumentation; Physics, Applied
SC Engineering; Science & Technology - Other Topics; Instruments &
Instrumentation; Physics
GA 151HM
UT WOS:000319451300017
ER
PT J
AU Lendvay, TS
Brand, TC
White, L
Kowalewski, T
Jonnadula, S
Mercer, LD
Khorsand, D
Andros, J
Hannaford, B
Satava, RM
AF Lendvay, Thomas S.
Brand, Timothy C.
White, Lee
Kowalewski, Timothy
Jonnadula, Saikiran
Mercer, Laina D.
Khorsand, Derek
Andros, Justin
Hannaford, Blake
Satava, Richard M.
TI Virtual Reality Robotic Surgery Warm-Up Improves Task Performance in a
Dry Laboratory Environment: A Prospective Randomized Controlled Study
SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
LA English
DT Article
ID LAPAROSCOPIC RENAL SURGERY; OPERATING-ROOM; SKILLS; SIMULATOR;
FUNDAMENTALS; ACQUISITION; VALIDATION; DECREMENT; EDUCATION
AB BACKGROUND: Preoperative simulation warm-up has been shown to improve performance and reduce errors in novice and experienced surgeons, yet existing studies have only investigated conventional laparoscopy. We hypothesized that a brief virtual reality (VR) robotic warm-up would enhance robotic task performance and reduce errors.
STUDY DESIGN: In a 2-center randomized trial, 51 residents and experienced minimally invasive surgery faculty in General Surgery, Urology, and Gynecology underwent a validated robotic surgery proficiency curriculum on a VR robotic simulator and on the da Vinci surgical robot (Intuitive Surgical Inc). Once they successfully achieved performance benchmarks, surgeons were randomized to either receive a 3- to 5-minute VR simulator warm-up or read a leisure book for 10 minutes before performing similar and dissimilar (intracorporeal suturing) robotic surgery tasks. The primary outcomes compared were task time, tool path length, economy of motion, technical, and cognitive errors.
RESULTS: Task time (-29.29 seconds, p = 0.001; 95% CI, -47.03 to -11.56), path length (-79.87 mm; p = 0.014; 95% CI, - 144.48 to - 15.25), and cognitive errors were reduced in the warm-up group compared with the control group for similar tasks. Global technical errors in intracorporeal suturing (0.32; p = 0.020; 95% CI, 0.06 - 0.59) were reduced after the dissimilar VR task. When surgeons were stratified by earlier robotic and laparoscopic clinical experience, the more experienced surgeons (n = 17) demonstrated significant improvements from warm-up in task time (- 53.5 seconds; p = 0.001; 95% CI, - 83.9 to - 23.0) and economy of motion (0.63 mm/s; p = 0.007; 95% CI, 0.18-1.09), and improvement in these metrics was not statistically significantly appreciated in the less-experienced cohort (n = 34).
CONCLUSIONS: We observed significant performance improvement and error reduction rates among surgeons of varying experience after VR warm-up for basic robotic surgery tasks. In addition, the VR warm-up reduced errors on a more complex task (robotic suturing), suggesting the generalizability of the warm-up. (J Am Coll Surg 2013; 216: 1181-1192. (C) 2013 by the American College of Surgeons)
C1 [Lendvay, Thomas S.] Univ Washington, Sch Med, Dept Urol, Seattle, WA 98195 USA.
[Jonnadula, Saikiran; Khorsand, Derek; Andros, Justin; Satava, Richard M.] Univ Washington, Sch Med, Dept Surg, Seattle, WA 98195 USA.
[White, Lee] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA.
[Kowalewski, Timothy; Hannaford, Blake] Univ Washington, Dept Elect Engn, Seattle, WA 98195 USA.
[Mercer, Laina D.] Seattle Childrens Res Inst, Core Biomed Stat, Seattle, WA USA.
[Brand, Timothy C.] USA, Madigan Army Med Ctr, Tacoma, WA USA.
RP Lendvay, TS (reprint author), Seattle Childrens Hosp, 4800 Sand Point Way NE, Seattle, WA 98105 USA.
EM thomas.lendvay@seattlechildrens.org
RI Kowalewski, Timothy/C-1391-2014
OI Kowalewski, Timothy/0000-0001-6596-3324
FU Department of Defense US Army Medical Research and Materiel Command
[W81XWH-09-1-0714]; Center for Clinical and Translational Research at
Seattle Children's Research Institute; NIH National Center for Research
Resources [UL1RR025014]
FX This study was supported by the Department of Defense US Army Medical
Research and Materiel Command under award number W81XWH-09-1-0714
(principal investigator: Lendvay). The views, opinions, and endorsement
by the author(s) do not reflect those of the US Army or the Department
of Defense.; The Seattle Children's Core for Biomedical Statistics is
supported by the Center for Clinical and Translational Research at
Seattle Children's Research Institute and grant UL1RR025014 from the NIH
National Center for Research Resources.
NR 39
TC 29
Z9 29
U1 1
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1072-7515
J9 J AM COLL SURGEONS
JI J. Am. Coll. Surg.
PD JUN
PY 2013
VL 216
IS 6
BP 1181
EP 1192
DI 10.1016/j.jamcollsurg.2013.02.012
PG 12
WC Surgery
SC Surgery
GA 145TG
UT WOS:000319039900020
PM 23583618
ER
PT J
AU Miotto, O
Almagro-Garcia, J
Manske, M
MacInnis, B
Campino, S
Rockett, KA
Amaratunga, C
Lim, P
Suon, S
Sreng, S
Anderson, JM
Duong, S
Nguon, C
Chuor, CM
Saunders, D
Se, Y
Lon, C
Fukuda, MM
Amenga-Etego, L
Hodgson, AVO
Asoala, V
Imwong, M
Takala-Harrison, S
Nosten, F
Su, XZ
Ringwald, P
Ariey, F
Dolecek, C
Hien, TT
Boni, MF
Thai, CQ
Amambua-Ngwa, A
Conway, DJ
Djimde, AA
Doumbo, OK
Zongo, I
Ouedraogo, JB
Alcock, D
Drury, E
Auburn, S
Koch, O
Sanders, M
Hubbart, C
Maslen, G
Ruano-Rubio, V
Jyothi, D
Miles, A
O'Brien, J
Gamble, C
Oyola, SO
Rayner, JC
Newbold, CI
Berriman, M
Spencer, CCA
McVean, G
Day, NP
White, NJ
Bethell, D
Dondorp, AM
Plowe, CV
Fairhurst, RM
Kwiatkowski, DP
AF Miotto, Olivo
Almagro-Garcia, Jacob
Manske, Magnus
MacInnis, Bronwyn
Campino, Susana
Rockett, Kirk A.
Amaratunga, Chanaki
Lim, Pharath
Suon, Seila
Sreng, Sokunthea
Anderson, Jennifer M.
Duong, Socheat
Nguon, Chea
Chuor, Char Meng
Saunders, David
Se, Youry
Lon, Chantap
Fukuda, Mark M.
Amenga-Etego, Lucas
Hodgson, Abraham V. O.
Asoala, Victor
Imwong, Mallika
Takala-Harrison, Shannon
Nosten, Francois
Su, Xin-zhuan
Ringwald, Pascal
Ariey, Frederic
Dolecek, Christiane
Tran Tinh Hien
Boni, Maciej F.
Cao Quang Thai
Amambua-Ngwa, Alfred
Conway, David J.
Djimde, Abdoulaye A.
Doumbo, Ogobara K.
Zongo, Issaka
Ouedraogo, Jean-Bosco
Alcock, Daniel
Drury, Eleanor
Auburn, Sarah
Koch, Oliver
Sanders, Mandy
Hubbart, Christina
Maslen, Gareth
Ruano-Rubio, Valentin
Jyothi, Dushyanth
Miles, Alistair
O'Brien, John
Gamble, Chris
Oyola, Samuel O.
Rayner, Julian C.
Newbold, Chris I.
Berriman, Matthew
Spencer, Chris C. A.
McVean, Gilean
Day, Nicholas P.
White, Nicholas J.
Bethell, Delia
Dondorp, Arjen M.
Plowe, Christopher V.
Fairhurst, Rick M.
Kwiatkowski, Dominic P.
TI Multiple populations of artemisinin-resistant Plasmodium falciparum in
Cambodia
SO NATURE GENETICS
LA English
DT Article
ID PARASITE CLEARANCE RATE; CHLOROQUINE RESISTANCE; WESTERN CAMBODIA;
DRUG-RESISTANCE; DIHYDROPTEROATE SYNTHASE; DIHYDROFOLATE-REDUCTASE;
MALARIA PARASITES; SPREAD; PYRIMETHAMINE; GENOME
AB We describe an analysis of genome variation in 825 P. falciparum samples from Asia and Africa that identifies an unusual pattern of parasite population structure at the epicenter of artemisinin resistance in western Cambodia. Within this relatively small geographic area, we have discovered several distinct but apparently sympatric parasite subpopulations with extremely high levels of genetic differentiation. Of particular interest are three subpopulations, all associated with clinical resistance to artemisinin, which have skewed allele frequency spectra and high levels of haplotype homozygosity, indicative of founder effects and recent population expansion. We provide a catalog of SNPs that show high levels of differentiation in the artemisinin-resistant subpopulations, including codon variants in transporter proteins and DNA mismatch repair proteins. These data provide a population-level genetic framework for investigating the biological origins of artemisinin resistance and for defining molecular markers to assist in its elimination.
C1 [Miotto, Olivo; Almagro-Garcia, Jacob; Rockett, Kirk A.; Amenga-Etego, Lucas; Koch, Oliver; Miles, Alistair; Newbold, Chris I.; Spencer, Chris C. A.; Kwiatkowski, Dominic P.] Univ Oxford, MRC, Ctr Genom & Global Hlth, Oxford, England.
[Miotto, Olivo; Imwong, Mallika; Nosten, Francois; Day, Nicholas P.; White, Nicholas J.; Dondorp, Arjen M.] Mahidol Univ, Mahidol Oxford Trop Med Res Unit, Bangkok 10700, Thailand.
[Miotto, Olivo; Almagro-Garcia, Jacob; Manske, Magnus; MacInnis, Bronwyn; Campino, Susana; Rockett, Kirk A.; Alcock, Daniel; Drury, Eleanor; Sanders, Mandy; Maslen, Gareth; Ruano-Rubio, Valentin; Jyothi, Dushyanth; Oyola, Samuel O.; Rayner, Julian C.; Newbold, Chris I.; Berriman, Matthew; Kwiatkowski, Dominic P.] Wellcome Trust Sanger Inst, Cambridge, England.
[Almagro-Garcia, Jacob; Rockett, Kirk A.; Hubbart, Christina; Ruano-Rubio, Valentin; Miles, Alistair; O'Brien, John; Spencer, Chris C. A.; McVean, Gilean; Kwiatkowski, Dominic P.] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
[Amaratunga, Chanaki; Lim, Pharath; Anderson, Jennifer M.; Su, Xin-zhuan; Fairhurst, Rick M.] NIAID, US Natl Inst Hlth, Bethesda, MD 20892 USA.
[Lim, Pharath; Suon, Seila; Sreng, Sokunthea; Duong, Socheat; Nguon, Chea; Chuor, Char Meng] Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia.
[Saunders, David; Fukuda, Mark M.; Bethell, Delia] US Army Med Component, Armed Forces Res Inst Med Sci USAMC AFRIMS, Dept Immunol & Med, Bangkok, Thailand.
[Se, Youry; Lon, Chantap] USAMC AFRIMS, Phnom Penh, Cambodia.
[Fukuda, Mark M.] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA.
[Amenga-Etego, Lucas; Hodgson, Abraham V. O.; Asoala, Victor] Navrongo Hlth Res Ctr, Navrongo, Ghana.
[Imwong, Mallika] Mahidol Univ, Fac Trop Med, Dept Mol Trop Med & Genet, Bangkok, Thailand.
[Takala-Harrison, Shannon; Plowe, Christopher V.] Univ Maryland, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21201 USA.
[Nosten, Francois] Shoklo Malaria Res Unit, Mae Sot, Tak, Thailand.
[Nosten, Francois; Dolecek, Christiane; Tran Tinh Hien; Boni, Maciej F.; Day, Nicholas P.; White, Nicholas J.; Dondorp, Arjen M.] Univ Oxford, Ctr Trop Med, Oxford, England.
[Ringwald, Pascal] WHO, Global Malaria Programme, CH-1211 Geneva, Switzerland.
[Ariey, Frederic] Inst Pasteur, Unite Immunol Mol Parasites, Paris, France.
[Dolecek, Christiane; Tran Tinh Hien; Boni, Maciej F.; Cao Quang Thai] Oxford Univ Clin Res Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam.
[Amambua-Ngwa, Alfred; Conway, David J.] MRC Labs, Fajara, Gambia.
[Conway, David J.] Univ London London Sch Hyg & Trop Med, London WC1E 7HT, England.
[Djimde, Abdoulaye A.; Doumbo, Ogobara K.] Univ Sci Tech & Technol Bamako, Fac Pharm, Malaria Res & Training Ctr, Bamako, Mali.
[Zongo, Issaka; Ouedraogo, Jean-Bosco] Direct Reg Ouest, Inst Rech Sci Sante, Bobo Dioulasso, Burkina Faso.
[Auburn, Sarah] Charles Darwin Univ, Menzies Sch Hlth Res, Darwin, NT 0909, Australia.
[Gamble, Chris] Univ Oxford, Dept Stat, Oxford OX1 3TG, England.
[Newbold, Chris I.] Univ Oxford, Weatherall Inst Mol Med, Oxford, England.
RP Kwiatkowski, DP (reprint author), Univ Oxford, MRC, Ctr Genom & Global Hlth, Oxford, England.
EM dominic@sanger.ac.uk
RI Valle, Ruben/A-7512-2013; Koch, Oliver/A-9480-2016; Jyothi,
Dushyanth/H-9517-2014;
OI Mead, Daniel/0000-0001-7717-4330; Manske, Magnus/0000-0001-5916-0947;
Nosten, Francois/0000-0002-7951-0745; Oyola, Samuel
O./0000-0002-6425-7345; Rayner, Julian/0000-0002-9835-1014; Su,
Xinzhuan/0000-0003-3246-3248; Auburn, Sarah/0000-0002-4638-536X; Jyothi,
Dushyanth/0000-0002-0448-5303; McVean, Gil/0000-0002-5012-4162; Newbold,
Chris/0000-0002-9274-3789; Conway, David/0000-0002-8711-3037; Miotto,
Olivo/0000-0001-8060-6771; Kwiatkowski, Dominic/0000-0002-5023-0176
FU Wellcome Trust through core funding of the Wellcome Trust Sanger
Institute [098051]; Wellcome Trust through core funding of the Wellcome
Trust Centre for Human Genetics [090532/Z/09/Z]; Wellcome Trust through
a Strategic Award [090770/Z/09/Z]; MRC through the MRC Centre for
Genomics and Global Health [G0600718]; MRC through an MRC Professorship
[G19/9]; Wellcome Trust; MRC; Division of Intramural Research, National
Institute of Allergy and Infectious Diseases, US National Institutes of
Health; Howard Hughes Medical Institute International Scholarship
[55005502]
FX We would like to thank V. Cornelius and R. Giacomantonio for their
support in producing and reviewing this manuscript; S. Uk and E.S.
Phelps for their contributions in the Cambodian studies; and T. Anderson
for helpful review comments. The sequencing, genotyping and analysis
components of this study were supported by the Wellcome Trust through
core funding of the Wellcome Trust Sanger Institute (098051), core
funding of the Wellcome Trust Centre for Human Genetics (090532/Z/09/Z)
and a Strategic Award (090770/Z/09/Z) and the MRC through the MRC Centre
for Genomics and Global Health (G0600718) and an MRC Professorship to
D.P.K. (G19/9). Other parts of this study were partly supported by the
Wellcome Trust; the MRC; the Division of Intramural Research, National
Institute of Allergy and Infectious Diseases, US National Institutes of
Health; and a Howard Hughes Medical Institute International Scholarship
(55005502) to A.A.D. P.R. is a staff member of the World Health
Organization; he alone is responsible for the views expressed in this
publication, and they do not necessarily represent the decisions, policy
or views of the World Health Organization.
NR 45
TC 183
Z9 186
U1 5
U2 65
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1061-4036
EI 1546-1718
J9 NAT GENET
JI Nature Genet.
PD JUN
PY 2013
VL 45
IS 6
BP 648
EP +
DI 10.1038/ng.2624
PG 10
WC Genetics & Heredity
SC Genetics & Heredity
GA 152XA
UT WOS:000319563900012
PM 23624527
ER
PT J
AU Chung, CC
Kanetsky, PA
Wang, ZM
Hildebrandt, MAT
Koster, R
Skotheim, RI
Kratz, CP
Turnbull, C
Cortessis, VK
Bakken, AC
Bishop, DT
Cook, MB
Erickson, RL
Fossa, SD
Jacobs, KB
Korde, LA
Kraggerud, SM
Lothe, RA
Loud, JT
Rahman, N
Skinner, EC
Thomas, DC
Wu, XF
Yeager, M
Schumacher, FR
Greene, MH
Schwartz, SM
McGlynn, KA
Chanock, SJ
Nathanson, KL
AF Chung, Charles C.
Kanetsky, Peter A.
Wang, Zhaoming
Hildebrandt, Michelle A. T.
Koster, Roelof
Skotheim, Rolf I.
Kratz, Christian P.
Turnbull, Clare
Cortessis, Victoria K.
Bakken, Anne C.
Bishop, D. Timothy
Cook, Michael B.
Erickson, R. Loren
Fossa, Sophie D.
Jacobs, Kevin B.
Korde, Larissa A.
Kraggerud, Sigrid M.
Lothe, Ragnhild A.
Loud, Jennifer T.
Rahman, Nazneen
Skinner, Eila C.
Thomas, Duncan C.
Wu, Xifeng
Yeager, Meredith
Schumacher, Fredrick R.
Greene, Mark H.
Schwartz, Stephen M.
McGlynn, Katherine A.
Chanock, Stephen J.
Nathanson, Katherine L.
TI Meta-analysis identifies four new loci associated with testicular germ
cell tumor
SO NATURE GENETICS
LA English
DT Article
ID GENOME-WIDE ASSOCIATION; MIXED LINEAGE KINASE; MULIBREY NANISM;
MARIJUANA USE; RECOMBINATION HOTSPOTS; LINKAGE DISEQUILIBRIUM;
CANCER-PATIENTS; OVARIAN-CANCER; DOMAIN-LIKE; DNA-DAMAGE
AB We conducted a meta-analysis to identify new susceptibility loci for testicular germ cell tumor (TGCT). In the discovery phase, we analyzed 931 affected individuals and 1,975 controls from 3 genome-wide association studies (GWAS). We conducted replication in 6 independent sample sets comprising 3,211 affected individuals and 7,591 controls. In the combined analysis, risk of TGCT was significantly associated with markers at four previously unreported loci: 4q22.2 in HPGDS (per-allele odds ratio (OR) = 1.19, 95% confidence interval (CI) = 1.12-1.26; P = 1.11 x 10(-8)), 7p22.3 in MAD1L1 (OR = 1.21, 95% CI = 1.14-1.29; P = 5.59 x 10(-9)), 16q22.3 in RFWD3 (OR = 1.26, 95% CI = 1.18-1.34; P = 5.15 x 10(-12)) and 17q22 (rs9905704: OR = 1.27, 95% CI = 1.18-1.33; P = 4.32 x 10(-13) and rs7221274: OR = 1.20, 95% CI = 1.12-1.28; P = 4.04 x 10(-9)), a locus that includes TEX14, RAD51C and PPM1E. These new TGCT susceptibility loci contain biologically plausible genes encoding proteins important for male germ cell development, chromosomal segregation and the DNA damage response.
C1 [Chung, Charles C.; Wang, Zhaoming; Kratz, Christian P.; Cook, Michael B.; Jacobs, Kevin B.; Korde, Larissa A.; Loud, Jennifer T.; Yeager, Meredith; Greene, Mark H.; McGlynn, Katherine A.; Chanock, Stephen J.] NCI, Div Canc Epidemiol & Genet, US Natl Inst Hlth, US Dept HHS, Bethesda, MD 20892 USA.
[Chung, Charles C.; Wang, Zhaoming; Jacobs, Kevin B.; Yeager, Meredith] NCI Frederick, Canc Genome Res Lab, Div Canc Epidemiol & Genet, SAIC Frederick, Frederick, MD USA.
[Kanetsky, Peter A.; Nathanson, Katherine L.] Univ Penn, Dept Biostat & Epidemiol, Perelman Sch Med, Philadelphia, PA 19104 USA.
[Kanetsky, Peter A.] Univ Penn, Abramson Canc Ctr, Perelman Sch Med, Philadelphia, PA 19104 USA.
[Hildebrandt, Michelle A. T.; Wu, Xifeng] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA.
[Koster, Roelof; Nathanson, Katherine L.] Univ Penn, Perelman Sch Med, Dept Med Translat Med & Human Genet, Philadelphia, PA 19104 USA.
[Skotheim, Rolf I.; Bakken, Anne C.; Kraggerud, Sigrid M.; Lothe, Ragnhild A.] Oslo Univ Hosp, Inst Canc Res, Dept Canc Prevent, Norwegian Radium Hosp, Oslo, Norway.
[Skotheim, Rolf I.; Bakken, Anne C.; Kraggerud, Sigrid M.; Lothe, Ragnhild A.] Univ Oslo, Fac Med, Ctr Canc Biomed, Oslo, Norway.
[Turnbull, Clare; Rahman, Nazneen] Inst Canc Res, Div Genet & Epidemiol, Sutton, Surrey, England.
[Cortessis, Victoria K.; Thomas, Duncan C.; Schumacher, Fredrick R.] Univ So Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA.
[Bishop, D. Timothy] St James Univ Hosp, Leeds Inst Mol Med, Sect Epidemiol & Biostat, Canc Res UK Clin Ctr Leeds, Leeds, W Yorkshire, England.
[Erickson, R. Loren] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Fossa, Sophie D.] Univ Oslo, Dept Oncol, Norwegian Radium Hosp, Oslo Univ Hosp, Oslo, Norway.
[Korde, Larissa A.] Univ Washington, Div Med Oncol, Seattle Canc Care Alliance, Seattle, WA 98195 USA.
[Skinner, Eila C.] Stanford Univ, Dept Urol, Stanford, CA 94305 USA.
[Schwartz, Stephen M.] Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle, WA 98195 USA.
[Schwartz, Stephen M.] Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.
RP Nathanson, KL (reprint author), Univ Penn, Dept Biostat & Epidemiol, Perelman Sch Med, Philadelphia, PA 19104 USA.
EM knathans@exchange.upenn.edu
RI Cook, Michael/A-5641-2009; Koster, Roelof/E-2158-2016;
OI Cook, Michael/0000-0002-0533-7302; Koster, Roelof/0000-0003-1424-8579;
Schwartz, Stephen/0000-0001-7499-8502; Nathanson,
Katherine/0000-0002-6740-0901; Bishop, Tim/0000-0002-8752-8785
FU Intramural Research Program of the NCI; Westat, Inc.
[HHSN261200655004C]; Abramson Cancer Center at the University of
Pennsylvania; US National Institutes of Health grant [R01CA114478,
R01CA085914]; Multiethnic Cohort Study [NCI U01-CA98758]; California
Cancer Research Program [99-00505V-10260, 03-00174VRS-30021]; NCI grant
[R01CA102042]; Whittier Foundation; Center for Translational and Public
Health Genomics of the Duncan Family Institute for Cancer Prevention and
Risk Assessment; MD Anderson Senior Research Trust Fellowship; Institute
of Cancer Research; Wellcome Trust; Norwegian Cancer Society; Health
Region South-Eastern Norway; Norwegian ExtraFoundation for Health and
Rehabilitation; Cancer Research UK
FX A portion of this work was supported by the Intramural Research Program
of the NCI and by support services contract HHSN261200655004C with
Westat, Inc. The Penn GWAS (UPENN) and replication effort for the
TestPAC study were supported by the Abramson Cancer Center at the
University of Pennsylvania and US National Institutes of Health grant
R01CA114478 to P.A.K. and K.L.N. The replication effort for the ATLAS
study was supported by US National Institutes of Health grant
R01CA085914 to S.M.S. The analysis of the USC GWAS controls was
supported by the Multiethnic Cohort Study (NCI U01-CA98758). The
analyses of the USC GWAS testicular cases and the Familial Study were
supported by the California Cancer Research Program (99-00505V-10260 and
03-00174VRS-30021) and by an NCI grant (R01CA102042) to V.K.C. and a
Whittier Foundation award to the Norris Comprehensive Cancer Center. The
study at MD Anderson was supported by the Center for Translational and
Public Health Genomics of the Duncan Family Institute for Cancer
Prevention and Risk Assessment and by an MD Anderson Senior Research
Trust Fellowship to X.W. The UK testicular cancer study was supported by
the Institute of Cancer Research, Cancer Research UK and the Wellcome
Trust and made use of control data generated by the Wellcome Trust Case
Control Consortium 2 (WTCCC2). Support was provided by the Norwegian
Cancer Society to R.A.L. and R.I.S., by Health Region South-Eastern
Norway to R.A.L. and S.D.F., and by the Norwegian ExtraFoundation for
Health and Rehabilitation to S.D.F.
NR 70
TC 61
Z9 62
U1 1
U2 17
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1061-4036
J9 NAT GENET
JI Nature Genet.
PD JUN
PY 2013
VL 45
IS 6
BP 680
EP +
DI 10.1038/ng.2634
PG 7
WC Genetics & Heredity
SC Genetics & Heredity
GA 152XA
UT WOS:000319563900017
PM 23666239
ER
PT J
AU Gribok, A
Hoyt, R
Buller, M
Rumpler, W
AF Gribok, Andrei
Hoyt, Reed
Buller, Mark
Rumpler, William
TI On the accuracy of instantaneous gas exchange rates, energy expenditure
and respiratory quotient calculations obtained from indirect whole room
calorimetry
SO PHYSIOLOGICAL MEASUREMENT
LA English
DT Article; Proceedings Paper
CT 13th International Conference on Biomedical Applications of Electrical
Impedance Tomography (EIT)
CY MAY 23-25, 2012
CL Tianjin, PEOPLES R CHINA
DE indirect calorimetry; uncertainty; regularization
ID BODY INDIRECT CALORIMETER; TRANSIENT-RESPONSE; DECONVOLUTION; CHAMBER
AB This paper analyzes the accuracy of metabolic rate calculations performed in the whole room indirect calorimeter using the molar balance equations. The equations are treated from the point of view of cause-effect relationship where the gaseous exchange rates representing the unknown causes need to be inferred from a known, noisy effect-gaseous concentrations. Two methods of such inference are analyzed. The first method is based on the previously published regularized deconvolution of the molar balance equation and the second one, proposed in this paper, relies on regularized differentiation of gaseous concentrations. It is found that both methods produce similar results for the absolute values of metabolic variables and their accuracy. The uncertainty for O-2 consumption rate is found to be 7% and for CO2 production-3.2%. The uncertainties in gaseous exchange rates do not depend on the absolute values of O-2 consumption and CO2 production. In contrast, the absolute uncertainty in respiratory quotient is a function of the gaseous exchange rates and varies from 9.4% during the night to 2.3% during moderate exercise. The uncertainty in energy expenditure was found to be 5.9% and independent of the level of gaseous exchange. For both methods, closed form analytical formulas for confidence intervals are provided allowing quantification of uncertainty for four major metabolic variables in real world studies.
C1 [Gribok, Andrei; Rumpler, William] ARS, Food Components & Hlth Lab, Beltsville Human Nutr Res Ctr, USDA, Beltsville, MD 20705 USA.
[Hoyt, Reed; Buller, Mark] USA, Biophys & Biomed Modeling Div, Environm Med Res Inst, Natick, MA 01760 USA.
RP Gribok, A (reprint author), ARS, Food Components & Hlth Lab, Beltsville Human Nutr Res Ctr, USDA, Beltsville, MD 20705 USA.
EM agribok@utk.edu
NR 22
TC 1
Z9 1
U1 1
U2 12
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0967-3334
EI 1361-6579
J9 PHYSIOL MEAS
JI Physiol. Meas.
PD JUN
PY 2013
VL 34
IS 6
BP 737
EP 755
DI 10.1088/0967-3334/34/6/737
PG 19
WC Biophysics; Engineering, Biomedical; Physiology
SC Biophysics; Engineering; Physiology
GA 152WS
UT WOS:000319563000013
PM 23719329
ER
PT J
AU Porter, MD
Nicki, J
Pool, CD
DeBot, M
Illam, RM
Brando, C
Bozick, B
De La Vega, P
Angra, D
Spaccapelo, R
Crisanti, A
Murphy, JR
Bennett, JW
Schwenk, RJ
Ockenhouse, CF
Dutta, S
AF Porter, Michael D.
Nicki, Jennifer
Pool, Christopher D.
DeBot, Margot
Illam, Ratish M.
Brando, Clara
Bozick, Brooke
De La Vega, Patricia
Angra, Divya
Spaccapelo, Roberta
Crisanti, Andrea
Murphy, Jittawadee R.
Bennett, Jason W.
Schwenk, Robert J.
Ockenhouse, Christian F.
Dutta, Sheetij
TI Transgenic Parasites Stably Expressing Full-Length Plasmodium falciparum
Circumsporozoite Protein as a Model for Vaccine Down-Selection in Mice
Using Sterile Protection as an Endpoint
SO CLINICAL AND VACCINE IMMUNOLOGY
LA English
DT Article
ID MALARIA VACCINES; AOTUS MONKEYS; SPOROZOITES; IMMUNITY; STRAIN;
EFFICACY; INVASION; ELICITS; SAFETY
AB Circumsporozoite protein (CSP) of Plasmodium falciparum is a protective human malaria vaccine candidate. There is an urgent need for models that can rapidly down-select novel CSP-based vaccine candidates. In the present study, the mouse-mosquito transmission cycle of a transgenic Plasmodium berghei malaria parasite stably expressing a functional full-length P. falciparum CSP was optimized to consistently produce infective sporozoites for protection studies. A minimal sporozoite challenge dose was established, and protection was defined as the absence of blood-stage parasites 14 days after intravenous challenge. The specificity of protection was confirmed by vaccinating mice with multiple CSP constructs of differing lengths and compositions. Constructs that induced high NANP repeat-specific antibody titers in enzyme-linked immunosorbent assays were protective, and the degree of protection was dependent on the antigen dose. There was a positive correlation between antibody avidity and protection. The antibodies in the protected mice recognized the native CSP on the parasites and showed sporozoite invasion inhibitory activity. Passive transfer of anti-CSP antibodies into naive mice also induced protection. Thus, we have demonstrated the utility of a mouse efficacy model to down-select human CSP-based vaccine formulations.
C1 [Porter, Michael D.; Nicki, Jennifer; Pool, Christopher D.; DeBot, Margot; Illam, Ratish M.; De La Vega, Patricia; Angra, Divya; Bennett, Jason W.; Schwenk, Robert J.; Ockenhouse, Christian F.; Dutta, Sheetij] Walter Reed Army Inst Res, Malaria Vaccine Dev Branch, Silver Spring, MD USA.
[Brando, Clara; Bozick, Brooke; Murphy, Jittawadee R.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD USA.
[Spaccapelo, Roberta] Univ Perugia, I-06100 Perugia, Italy.
[Crisanti, Andrea] Univ London Imperial Coll Sci Technol & Med, London, England.
RP Dutta, S (reprint author), Walter Reed Army Inst Res, Malaria Vaccine Dev Branch, Silver Spring, MD USA.
EM sheetij.dutta@us.army.mil
RI Bennett, Jason/B-3547-2011
FU USAID Malaria Vaccine Development Program
FX The funding for this work was provided by the USAID Malaria Vaccine
Development Program.
NR 24
TC 14
Z9 14
U1 1
U2 12
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 1556-6811
J9 CLIN VACCINE IMMUNOL
JI Clin. Vaccine Immunol.
PD JUN
PY 2013
VL 20
IS 6
BP 803
EP 810
DI 10.1128/CVI.00066-13
PG 8
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 151HO
UT WOS:000319451500005
PM 23536694
ER
PT J
AU Zhang, SS
AF Zhang, Sheng S.
TI Does the sulfur cathode require good mixing for a liquid electrolyte
lithium/sulfur cell?
SO ELECTROCHEMISTRY COMMUNICATIONS
LA English
DT Article
DE Lithium/sulfur cell; Sulfur cathode; Liquid electrolyte; Polysulfide; Ac
impedance
ID GRAPHITE-ELECTRODES; BATTERIES; INTERCALATION; IMPEDANCE; IONS
AB In order to demonstrate whether the sulfur cathode of a liquid electrolyte lithium/sulfur (Li/S) cell requires good mixing, we intentionally prepare the following three cathodes: (1) Cathode A made by spreading a sulfur/carbon disulfide solution onto a porous carbon electrode, (2) Cathode B made by laminating a porous carbon layer and a pure sulfur layer together, and (3) Cathode C made by soaking a carbon cloth into a sulfur/carbon disulfide solution and then evaporating the solvent. Without any milling treatments, the large yellow sulfur particles/crystals are visually visible in all three cathodes. Even using these cathodes without mixing of the sulfur and conducting carbon, the Li/S cells still exhibit initial discharge capacities of 1218, 1337, and 966 mAh g(-1) for Cathodes A, B, C, respectively, and maintain comparable capacity retentions as compared with the conventional Li/S cells. These results reveal that the initial mixing status of the cathode does not affect the cycling performance of Li/S cells. In this paper, we discuss our results from the viewpoint of the Li/S fundamental chemistry and suggest more effective approaches for the performance improvement. Published by Elsevier B.V.
C1 USA, Res Lab, Electrochem Branch, RDRL SED C Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Zhang, SS (reprint author), USA, Res Lab, Electrochem Branch, RDRL SED C Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
EM shengshui.zhang.civ@mail.mil
RI Zhang, Sheng/A-4456-2012
OI Zhang, Sheng/0000-0003-4435-4110
NR 13
TC 28
Z9 28
U1 10
U2 169
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1388-2481
J9 ELECTROCHEM COMMUN
JI Electrochem. Commun.
PD JUN
PY 2013
VL 31
BP 10
EP 12
DI 10.1016/j.elecom.2013.02.021
PG 3
WC Electrochemistry
SC Electrochemistry
GA 148IA
UT WOS:000319236800003
ER
PT J
AU Da, DF
Dixit, S
Sattabonkot, J
Mu, JB
Abate, L
Ramineni, B
Ouedraogo, JB
MacDonald, NJ
Fay, MP
Su, XZ
Cohuet, A
Wu, YM
AF Da, Dari F.
Dixit, Saurabh
Sattabonkot, Jetsumon
Mu, Jianbing
Abate, Luc
Ramineni, Bhanumati
Ouedraogo, Jean Bosco
MacDonald, Nicholas J.
Fay, Michael P.
Su, Xin-zhuan
Cohuet, Anna
Wu, Yimin
TI Anti-Pfs25 Human Plasma Reduces Transmission of Plasmodium falciparum
Isolates That Have Diverse Genetic Backgrounds
SO INFECTION AND IMMUNITY
LA English
DT Article
ID MALARIA TRANSMISSION; VACCINE CANDIDATE; BLOCKING VACCINE; SEXUAL STAGE;
INFECTIONS; ANTIGENS; POPULATIONS; TESTS
AB Pfs25 is a leading candidate for a malaria transmission-blocking vaccine whose potential has been demonstrated in a phase 1 trial with recombinant Pfs25 formulated with Montanide ISA51. Because of limited sequence polymorphism, the anti-Pfs25 antibodies induced by this vaccine are likely to have transmission-blocking or -reducing activity against most, if not all, field isolates. To test this hypothesis, we evaluated transmission-blocking activities by membrane feeding assay of anti-Pfs25 plasma from the Pfs25/ISA51 phase 1 trial against Plasmodium falciparum parasites from patients in two different geographical regions of the world, Thailand and Burkina Faso. In parallel, parasite isolates from these patients were sequenced for the Pfs25 gene and genotyped for seven microsatellites. The results indicate that despite different genetic backgrounds among parasite isolates, the Pfs25 sequences are highly conserved, with a single nonsynonymous nucleotide polymorphism detected in 1 of 41 patients in Thailand and Burkina Faso. The anti-Pfs25 immune plasma had significantly higher transmission-reducing activity against parasite isolates from the two geographical regions than the nonimmune controls (P < 0.0001).
C1 [Da, Dari F.; Ouedraogo, Jean Bosco; Cohuet, Anna] IRSS, Bobo Dioulasso, Burkina Faso.
[Da, Dari F.; Abate, Luc; Cohuet, Anna] UMR MIVEGEC UM1 UM2 CNRS 5290 IRD 224, IRD, Montpellier, France.
[Dixit, Saurabh; Ramineni, Bhanumati; MacDonald, Nicholas J.; Wu, Yimin] NIAID, Lab Malaria Immunol & Vaccinol, Rockville, MD USA.
[Sattabonkot, Jetsumon] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Mu, Jianbing; Su, Xin-zhuan] NIAID, Lab Malaria & Vector Res, Rockville, MD USA.
[Fay, Michael P.] NIAID, Biostat Res Branch, Bethesda, MD 20892 USA.
RP Wu, YM (reprint author), NIAID, Lab Malaria Immunol & Vaccinol, Rockville, MD USA.
EM yiwu@niaid.nih.gov
RI Cohuet, Anna/B-2745-2017;
OI Cohuet, Anna/0000-0002-1876-5656; Fay, Michael P./0000-0002-8643-9625;
Su, Xinzhuan/0000-0003-3246-3248
FU Division of Intramural Research, National Institute of Allergy and
Infectious Diseases, National Institutes of Health, United States;
European Community's Seventh Framework Program (FP7) [242095, 223736];
IRD
FX This work was supported by funding from the Division of Intramural
Research, National Institute of Allergy and Infectious Diseases,
National Institutes of Health, United States, and the European
Community's Seventh Framework Program (FP7/2007-2013) under grant
agreements 242095 and 223736. Also, we thank IRD for financial support
and for a fellowship to D.F.D.
NR 23
TC 7
Z9 7
U1 1
U2 10
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0019-9567
J9 INFECT IMMUN
JI Infect. Immun.
PD JUN
PY 2013
VL 81
IS 6
BP 1984
EP 1989
DI 10.1128/IAI.00016-13
PG 6
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 143GN
UT WOS:000318855100012
PM 23509152
ER
PT J
AU Jepsen, KJ
Evans, R
Negus, CH
Gagnier, JJ
Centi, A
Erlich, T
Hadid, A
Yanovich, R
Moran, DS
AF Jepsen, Karl J.
Evans, Rachel
Negus, Charles H.
Gagnier, Joel J.
Centi, Amanda
Erlich, Tomer
Hadid, Amir
Yanovich, Ran
Moran, Daniel S.
TI Variation in tibial functionality and fracture susceptibility among
healthy, young adults arises from the acquisition of biologically
distinct sets of traits
SO JOURNAL OF BONE AND MINERAL RESEARCH
LA English
DT Article
DE FUNCTIONAL ADAPTATION; STRESS FRACTURES; BIOMECHANICS; TIBIA; ADULT
ID STRESS-FRACTURE; BONE STRENGTH; STRUCTURAL GEOMETRY; SEXUAL-DIMORPHISM;
HIP FRACTURE; ELDERLY-MEN; GROWTH; RECRUITS; FRAGILITY; WOMEN
AB Physiological systems like bone respond to many genetic and environmental factors by adjusting traits in a highly coordinated, compensatory manner to establish organ-level function. To be mechanically functional, a bone should be sufficiently stiff and strong to support physiological loads. Factors impairing this process are expected to compromise strength and increase fracture risk. We tested the hypotheses that individuals with reduced stiffness relative to body size will show an increased risk of fracturing and that reduced strength arises from the acquisition of biologically distinct sets of traits (ie, different combinations of morphological and tissue-level mechanical properties). We assessed tibial functionality retrospectively for 336 young adult women and men engaged in military training, and calculated robustness (total area/bone length), cortical area (Ct.Ar), and tissue-mineral density (TMD). These three traits explained 69% to 72% of the variation in tibial stiffness (p<0.0001). Having reduced stiffness relative to body size (body weightxbone length) was associated with odds ratios of 1.5 (95% confidence interval [CI], 0.54.3) and 7.0 (95% CI, 2.025.1) for women and men, respectively, for developing a stress fracture based on radiography and scintigraphy. K-means cluster analysis was used to segregate men and women into subgroups based on robustness, Ct.Ar, and TMD adjusted for body size. Stiffness varied 37% to 42% among the clusters (p<0.0001, ANOVA). For men, 78% of stress fracture cases segregated to three clusters (p<0.03, chi-square). Clusters showing reduced function exhibited either slender tibias with the expected Ct.Ar and TMD relative to body size and robustness (ie, well-adapted bones) or robust tibias with reduced residuals for Ct.Ar or TMD relative to body size and robustness (ie, poorly adapted bones). Thus, we show there are multiple biomechanical and thus biological pathways leading to reduced function and increased fracture risk. Our results have important implications for developing personalized preventative diagnostics and treatments.
C1 [Jepsen, Karl J.; Gagnier, Joel J.] Univ Michigan, Dept Orthopaed Surg, Ann Arbor, MI 48109 USA.
[Evans, Rachel; Centi, Amanda] USA, Environm Med Res Inst, Natick, MA 01760 USA.
[Negus, Charles H.] L 3 Jaycor, San Diego, CA USA.
[Erlich, Tomer; Hadid, Amir; Yanovich, Ran; Moran, Daniel S.] Ariel Univ, Sheba Med Ctr, Heller Inst, Ariel, Israel.
RP Jepsen, KJ (reprint author), Univ Michigan, Dept Orthopaed Surg, Room 2007,Biomed Sci Res Bldg,109 Zina Pitcher Pl, Ann Arbor, MI 48109 USA.
EM kjepsen@umich.edu
FU U.S. Department of Defense [W81XWH-09-2-0113, W81XWH-07-C-0097]; medical
research and material command (MRMC) Bone Health Grant
FX This work was supported by grants from the U.S. Department of Defense
(W81XWH-09-2-0113, W81XWH-07-C-0097) and an medical research and
material command (MRMC) Bone Health Grant. The opinions or assertions
contained herein are the private views of the authors and are not to be
construed as official or as reflecting the views of the U.S. Army or the
Department of Defense.
NR 37
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U1 0
U2 9
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0884-0431
J9 J BONE MINER RES
JI J. Bone Miner. Res.
PD JUN
PY 2013
VL 28
IS 6
BP 1290
EP 1300
DI 10.1002/jbmr.1879
PG 11
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 149VS
UT WOS:000319350100007
PM 23362125
ER
PT J
AU Belenkiy, S
Ivey, KM
Batchinsky, AI
Langer, T
Necsoiu, C
Baker, W
Salinas, J
Cancio, LC
AF Belenkiy, Slava
Ivey, Katherine M.
Batchinsky, Andriy I.
Langer, Thomas
Necsoiu, Corina
Baker, William
Salinas, Jose
Cancio, Leopoldo C.
TI NONINVASIVE CARBON DIOXIDE MONITORING IN A PORCINE MODEL OF ACUTE LUNG
INJURY DUE TO SMOKE INHALATION AND BURNS
SO SHOCK
LA English
DT Article
DE Transcutaneous carbon dioxide; end-tidal carbon dioxide; blood gas
analysis; acute lung injury; swine; burns; inhalation injury
ID CRITICALLY-ILL; MECHANICAL VENTILATION; TRANSCUTANEOUS PCO2;
GENERAL-ANESTHESIA; OXYGEN-SATURATION; PARTIAL-PRESSURE; ADULTS;
ACCURACY; TENSION; CAPNOGRAPHY
AB In critically ill intubated patients, assessment of adequacy of ventilation relies on measuring partial pressure of arterial carbon dioxide (PaCO2), which requires invasive arterial blood gas analysis. Alternative noninvasive technologies include transcutaneous CO2 (tPCO(2)) and end-tidal CO2 (EtCO2) monitoring. We evaluated accuracy of tPCO(2) and EtCO2 monitoring in a porcine model of acute lung injury (ALI) due to smoke inhalation and burns. Eight anesthetized Yorkshire pigs underwent mechanical ventilation, wood-bark smoke inhalation injury, and 40% total body surface area thermal injury. tPCO(2) was measured with a SenTec system (SenTec AG, Therwil, Switzerland) and EtCO2 with a Capnostream-20 (Oridion Medical, Jerusalem, Israel). These values were compared with PaCO2 measurements from an arterial blood gas analyzer. Paired measurements of EtCO2-PaCO2 (n = 276) and tPCO(2)-PaCO2 (n = 250) were recorded in the PaCO2 range of 25 to 85 mmHg. Overlapping data sets were analyzed based on respiratory and hemodynamic status of animals. Acute lung injury was defined as PaO2/FIO2 <= 300 mmHg; hemodynamic instability was defined as mean arterial pressure <= 60 mmHg. Before ALI, EtCO2 demonstrated moderate correlation with PaCO2 (R-2 = 0.45; P < 0.0001), which deteriorated after onset of ALI (R-2 = 0.12; P < 0.0001). Before ALI, tPCO(2) demonstrated moderate correlation (R-2 = 0.51, P < 0.0001), which was sustained after onset of ALI (R-2 = 0.78; P < 0.0001). During hemodynamic stability, EtCO2 demonstrated moderate correlation with PaCO2 (R-2 = 0.44; P < 0.0001). During hemodynamic instability, EtCO2 did not correlate with PaCO2 (R-2 = 0.03; P = 0.29). tPCO(2) monitoring demonstrated strong correlation with PaCO2 during hemodynamic stability (R-2 = 0.80, P < 0.0001), which deteriorated under hemodynamically unstable conditions (R-2 = 0.39; P < 0.0001). Noninvasive carbon dioxide monitors are acceptable for monitoring trends in PaCO2 under conditions of hemodynamic and pulmonary stability. Under unstable conditions, reevaluation of patient status and increased caution in the interpretation of results are required.
C1 [Belenkiy, Slava; Ivey, Katherine M.; Batchinsky, Andriy I.; Langer, Thomas; Necsoiu, Corina; Baker, William; Salinas, Jose; Cancio, Leopoldo C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Belenkiy, Slava; Ivey, Katherine M.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA.
[Langer, Thomas] Univ Milan, Dipartimento Fisiopatol Med Chirurg & Trapianti, Milan, Italy.
RP Cancio, LC (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM lee.cancio@us.army.mil
FU Oridion, Inc; US Army Institute of Surgical Research; Combat Critical
Care Engineering Task Area, Combat Casualty Care Research Area
Directorate, US Army Medical Research, and Materiel Command
FX The authors thank Oridion, Inc, for providing support for this study,
under a Cooperative Research and Development Agreement with the US Army
Institute of Surgical Research.; This study was funded by the Combat
Critical Care Engineering Task Area, Combat Casualty Care Research Area
Directorate, US Army Medical Research, and Materiel Command.
NR 32
TC 10
Z9 10
U1 1
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1073-2322
J9 SHOCK
JI Shock
PD JUN
PY 2013
VL 39
IS 6
BP 495
EP 500
DI 10.1097/SHK.0b013e318292c331
PG 6
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA 147WL
UT WOS:000319200700005
PM 23572088
ER
PT J
AU McAlpin, TO
Sharp, JA
Scott, SH
Savant, G
AF McAlpin, Tate O.
Sharp, Jeremy A.
Scott, Stephen H.
Savant, Gaurav
TI Habitat Restoration and Flood Control Protection in the Kissimmee River
SO WETLANDS
LA English
DT Article
DE Kissimmee River; Adaptive Hydraulics; AdH; River Restoration
ID ECOSYSTEM
AB The Adaptive Hydraulics (AdH) code was applied to simulate the hydrodynamic conditions along a stretch of the Kissimmee River in an effort to determine the impacts associated with possible system restoration alternatives. The Kissimmee River Basin flood control project, completed in 1971, had a negative impact on the ecosystem of the Kissimmee River and the adjacent floodplain by reducing floodplain inundation. This numerical model study investigated the expected inundation amounts associated with two restoration alternatives with the first being a return to the historical system and the second being a restored system that would maintain some flood control measures. The model simulations indicate an increase of anywhere from 12 % to 33 % in the floodplain inundation associated with system alternatives when compared to the existing conditions. This indicates that implementation of either of these alternatives would improve the ecosystem productivity for this portion of the Kissimmee River with the restored alternative also providing some flood protection.
C1 [McAlpin, Tate O.; Sharp, Jeremy A.; Scott, Stephen H.] USA, Corps Engineers, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA.
[Savant, Gaurav] Dynam Solut LLC, Coastal & Hydraul Lab, Res Water Resources, USA,Corps Engineers, Vicksburg, MS 39180 USA.
RP McAlpin, TO (reprint author), USA, Corps Engineers, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA.
EM Tate.O.McAlpin@usace.army.mil
FU U.S. Army Corp of Engineers Jacksonville District
FX The work described and results presented in this paper were obtained
through research sponsored by the U.S. Army Corp of Engineers
Jacksonville District. Permission to publish this paper was granted by
the Chief of Engineers, U.S. Army Corp of Engineers. The authors would
also like to acknowledge the contributions of three anonymous reviewers
for comments and suggestions that improved the quality of this
manuscript.
NR 27
TC 0
Z9 0
U1 2
U2 39
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0277-5212
J9 WETLANDS
JI Wetlands
PD JUN
PY 2013
VL 33
IS 3
BP 551
EP 560
DI 10.1007/s13157-013-0412-2
PG 10
WC Ecology; Environmental Sciences
SC Environmental Sciences & Ecology
GA 142LC
UT WOS:000318797900015
ER
PT J
AU Taylor, GS
Barnett, JS
AF Taylor, Grant S.
Barnett, John S.
TI Evaluation of Wearable Simulation Interface for Military Training
SO HUMAN FACTORS
LA English
DT Article
DE simulator; training; computer interface; usability; training
effectiveness; training transfer; wearable simulation interface
ID PRESENCE QUESTIONNAIRE; VIRTUAL ENVIRONMENTS
AB Objective: This research evaluated the training effectiveness of a novel simulation interface, a wearable computer integrated into a soldier's load-bearing equipment.
Background: Military teams often use game-based simulators on desktop computers to train squad-level procedures. A wearable computer interface that mimics the soldier's equipment was expected to provide better training through increased realism and immersion.
Method: A heuristic usability evaluation and two experiments were conducted. Eight evaluators interacted with both wearable and desktop interfaces and completed a usability survey. The first experiment compared the training retention of the wearable interface with a desktop simulator and interactive training video. The second experiment compared the training transfer of the wearable and desktop simulators with a live training environment.
Results: Results indicated the wearable interface was more difficult to use and elicited stronger symptoms of simulator sickness. There was no significant difference in training retention between the wearable, desktop, or interactive video training methods. The live training used in the second experiment provided superior training transfer than the simulator conditions, with no difference between the desktop and wearable.
Conclusion: The wearable simulator interface did not provide better training than the desktop computer interface. It also had poorer usability and caused worse simulator sickness. Therefore, it was a less effective training tool.
Application: This research illustrates the importance of conducting empirical evaluations of novel training technologies. New and innovative technologies are always coveted by users, but new does not always guarantee improvement.
C1 [Taylor, Grant S.] Univ Cent Florida, Inst Simulat & Training, Appl Cognit & Training Immers Virtual Environm AC, Orlando, FL 32816 USA.
[Barnett, John S.] USA, Res Inst Behav & Social Sci, Technol Based Training Unit, Orlando, FL 32826 USA.
RP Barnett, JS (reprint author), USA, Res Inst, ATTN DAPE ARI IF, 12350 Res Pkwy, Orlando, FL 32826 USA.
EM john.barnett1@us.army.mil
NR 28
TC 0
Z9 0
U1 4
U2 21
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0018-7208
J9 HUM FACTORS
JI Hum. Factors
PD JUN
PY 2013
VL 55
IS 3
BP 672
EP 690
DI 10.1177/0018720812466892
PG 19
WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology,
Applied; Psychology
SC Behavioral Sciences; Engineering; Psychology
GA 144MF
UT WOS:000318942900017
PM 23829039
ER
PT J
AU Bartone, PT
Kelly, DR
Matthews, MD
AF Bartone, Paul T.
Kelly, Dennis R.
Matthews, Michael D.
TI Psychological Hardiness Predicts Adaptability in Military Leaders: A
prospective study
SO INTERNATIONAL JOURNAL OF SELECTION AND ASSESSMENT
LA English
DT Article
ID 5-FACTOR MODEL; TRANSFORMATIONAL LEADERSHIP; PERSONALITY HARDINESS;
ADAPTIVE PERFORMANCE; LIFE EVENTS; HEALTH; STRESS; BEHAVIOR; CADETS;
SCALE
AB To perform effectively in complex mission environments, security personnel and leaders must be flexible and adaptable in responding to rapidly changing conditions. Psychological hardiness marks resilient people who maintain their health and performance despite stressful situations. The present study evaluates psychological hardiness at entry to West Point military academy as a predictor of leader performance and adaptability over time. Predictors also included Scholastic Aptitude Test (SAT) scores, and a composite indicator of leader potential (Whole Candidate Score) taken from admissions records. Using the Pulakos adaptability taxonomy as a guide, adaptability performance items were taken from a survey of graduates given 3 years after graduation. Also, military leadership grades as West Point seniors provided an index of traditional military performance. Hierarchical regression analyses showed that Whole Candidate Scores predict military leader performance at West Point, but not leader adaptability after graduation. However, hardiness predicts leader performance at West Point, and also leader adaptability (self- and supervisor ratings) after graduation. SAT scores and the challenge facet of hardiness are negative predictors of leader performance at West Point. Results indicate that while the traditional measures Whole Candidate Score predicts leader performance in the stable, highly regulated environment of West Point, it does not predict leader adaptability and performance in the uncertain environment of real-world operations. In contrast, psychological hardiness (commitment and control facets) measured as academy freshmen predicts leader adaptability in officers measured 7 years later. Psychological hardiness appears to be a promising factor in promoting the development of adaptability.
C1 [Bartone, Paul T.] Natl Def Univ, Ctr Technol & Natl Secur Policy, Washington, DC 20319 USA.
[Kelly, Dennis R.; Matthews, Michael D.] US Mil Acad, West Point, NY 10996 USA.
RP Bartone, PT (reprint author), Natl Def Univ, Ctr Technol & Natl Secur Policy, Washington, DC 20319 USA.
EM bartonep@ndu.edu
OI Bartone, Paul/0000-0002-5767-0086
NR 77
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U1 5
U2 34
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0965-075X
EI 1468-2389
J9 INT J SELECT ASSESS
JI Int. J. Sel. Assess.
PD JUN
PY 2013
VL 21
IS 2
BP 200
EP 210
DI 10.1111/ijsa.12029
PG 11
WC Psychology, Applied; Management
SC Psychology; Business & Economics
GA 145IO
UT WOS:000319009000006
ER
PT J
AU Walberg, FC
Stark, TD
Nicholson, PJ
Castro, G
Byrne, PM
Axtell, PJ
Dillon, JC
Empson, WB
Topi, JE
Mathews, DL
Bellew, GM
AF Walberg, Francke C.
Stark, Timothy D.
Nicholson, Peter J.
Castro, Gonzalo
Byrne, Peter M.
Axtell, Paul J.
Dillon, John C.
Empson, William B.
Topi, Joseph E.
Mathews, David L.
Bellew, Glen M.
TI Seismic Retrofit of Tuttle Creek Dam
SO JOURNAL OF GEOTECHNICAL AND GEOENVIRONMENTAL ENGINEERING
LA English
DT Article
DE Jet grouting; soil mixing; cutoff walls; shear walls; soil mechanics;
permeability; liquefaction; earthquake induced displacement; slope
stability
AB This paper discusses the seismic retrofit of Tuttle Creek Dam near Manhattan, Kansas, including investigations, seismic analyses, design, construction, and stabilization techniques used. Original plans called for stabilization of the upstream and downstream slopes and installation of an upstream cutoff wall to reduce underseepage. However, constructability and dam safety issues, along with the results of refined seismic deformation analyses, led to cancellation of the jet grouted upstream slope stabilization and cutoff wall. Downstream slope stabilization was to be accomplished by jet grouting or soil mixing, but ultimately was accomplished using a self-hardening cement-bentonite (C-B) slurry to construct transverse shear walls. A total of 351 transverse shear walls were constructed along the downstream toe by primarily clamshell equipment. Typical shear walls are 13.7 m long, 1.2 m wide, and extend 18.9 m deep or about 6.1 m into the coarse foundation sands. The walls are spaced at 4.3 m on center along the downstream toe for a replacement ratio of about 29%. In addition to the transverse shear walls, the relief well collection ditch along the downstream toe was replaced with a buried collector system to further improve downstream stability and underseepage control. (C) 2013 American Society of Civil Engineers.
C1 [Walberg, Francke C.] URS Corp, Overland Pk, KS 66210 USA.
[Stark, Timothy D.] Univ Illinois, Urbana, IL 61801 USA.
[Nicholson, Peter J.] Nicholson Consulting LLC, Boca Raton, FL 33428 USA.
[Castro, Gonzalo] GEI Consultants Inc, Geotech Engineers Inc, Woburn, MA 01801 USA.
[Byrne, Peter M.] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada.
[Axtell, Paul J.] Dan Brown & Associates, Overland Pk, KS 66212 USA.
[Dillon, John C.] USA, Cost Estimating Sect, Corps Engineers, Kansas City, MO 64106 USA.
[Empson, William B.] USA, Risk Management Ctr West Denver, Inst Water Resources, Corps Engineers, Lakewood, CO 80288 USA.
[Topi, Joseph E.; Bellew, Glen M.] USA, Geotech Design & Dam Safety Sect, Corps Engineers, Kansas City, MO 64106 USA.
[Mathews, David L.] USA, Div Engn, Corps Engineers, Kansas City, MO 64106 USA.
RP Stark, TD (reprint author), Univ Illinois, 205 N Mathews Ave, Urbana, IL 61801 USA.
EM Francke_Walberg@URSCorp.com; tstark@illinois.edu
NR 24
TC 2
Z9 2
U1 0
U2 19
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 1090-0241
J9 J GEOTECH GEOENVIRON
JI J. Geotech. Geoenviron. Eng.
PD JUN
PY 2013
VL 139
IS 6
BP 975
EP 986
DI 10.1061/(ASCE)GT.1943-5606.0000818
PG 12
WC Engineering, Geological; Geosciences, Multidisciplinary
SC Engineering; Geology
GA 143PI
UT WOS:000318879300014
ER
PT J
AU Grujicic, M
Arakere, A
Ramaswami, S
Snipes, JS
Yavari, R
Yen, CF
Cheeseman, BA
Montgomery, JS
AF Grujicic, M.
Arakere, A.
Ramaswami, S.
Snipes, J. S.
Yavari, R.
Yen, C-F.
Cheeseman, B. A.
Montgomery, J. S.
TI Gas Metal Arc Welding Process Modeling and Prediction of Weld
Microstructure in MIL A46100 Armor-Grade Martensitic Steel
SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
LA English
DT Article
DE gas metal arc welding (GMAW); microstructure evolution; MIL A46100;
process modeling
ID KINETICS; TRANSFORMATION; REAUSTENITIZATION; THERMODYNAMICS; EVOLUTION;
AA5083
AB A conventional gas metal arc welding (GMAW) butt-joining process has been modeled using a two-way fully coupled, transient, thermal-mechanical finite-element procedure. To achieve two-way thermal-mechanical coupling, the work of plastic deformation resulting from potentially high thermal stresses is allowed to be dissipated in the form of heat, and the mechanical material model of the workpiece and the weld is made temperature dependent. Heat losses from the deposited filler-metal are accounted for by considering conduction to the adjoining workpieces as well as natural convection and radiation to the surroundings. The newly constructed GMAW process model is then applied, in conjunction with the basic material physical-metallurgy, to a prototypical high-hardness armor martensitic steel (MIL A46100). The main outcome of this procedure is the prediction of the spatial distribution of various crystalline phases within the weld and the heat-affected zone regions, as a function of the GMAW process parameters. The newly developed GMAW process model is validated by comparing its predictions with available open-literature experimental and computational data.
C1 [Grujicic, M.; Arakere, A.; Ramaswami, S.; Snipes, J. S.; Yavari, R.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA.
[Yen, C-F.; Cheeseman, B. A.; Montgomery, J. S.] USA, Res Lab, Survivabil Mat Branch, Proving Ground, MD 21005 USA.
RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA.
EM gmica@clemson.edu
FU Army Research Office [W911NF-11-1-0207, W911NF-09-1-0513]; US
Army/Clemson University [W911NF-04-2-0024, W911NF-06-2-0042]
FX The material presented in this article is based on the study supported
by two Army Research Office sponsored grants (W911NF-11-1-0207 and
W911NF-09-1-0513) and two US Army/Clemson University Cooperative
Agreements (W911NF-04-2-0024 and W911NF-06-2-0042). The authors are
indebted to Dr. Larry C. Russell, Jr. of ARO for his continuing support
and interest in this study.
NR 39
TC 13
Z9 13
U1 0
U2 20
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1059-9495
J9 J MATER ENG PERFORM
JI J. Mater. Eng. Perform.
PD JUN
PY 2013
VL 22
IS 6
BP 1541
EP 1557
DI 10.1007/s11665-012-0445-3
PG 17
WC Materials Science, Multidisciplinary
SC Materials Science
GA 143XR
UT WOS:000318903000003
ER
PT J
AU Sun, WB
Liu, ZY
Lin, B
Huang, JP
Videen, G
AF Sun, Wenbo
Liu, Zhaoyan
Lin, Bing
Huang, Jianping
Videen, Gorden
TI The 2nd International Symposium on Atmospheric Light Scattering and
Remote Sensing (ISALSaRS'11)
SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
LA English
DT Editorial Material
C1 [Lin, Bing] NASA, Langley Res Ctr, Washington, DC 20546 USA.
[Huang, Jianping] Lanzhou Univ, Lanzhou 730000, Peoples R China.
[Videen, Gorden] USA, Res Lab, Washington, DC 20546 USA.
EM wenbo.sun-1@nasa.gov
NR 0
TC 1
Z9 1
U1 1
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4073
J9 J QUANT SPECTROSC RA
JI J. Quant. Spectrosc. Radiat. Transf.
PD JUN
PY 2013
VL 122
SI SI
BP 1
EP 2
DI 10.1016/j.jqsrt.2012.12.005
PG 2
WC Optics; Spectroscopy
SC Optics; Spectroscopy
GA 142VN
UT WOS:000318825800001
ER
PT J
AU Sun, WB
Liu, ZY
Videen, G
Fu, Q
Muinonen, K
Winker, DM
Lukashin, C
Jin, ZH
Lin, B
Huang, JP
AF Sun, Wenbo
Liu, Zhaoyan
Videen, Gorden
Fu, Qiang
Muinonen, Karri
Winker, David M.
Lukashin, Constantine
Jin, Zhonghai
Lin, Bing
Huang, Jianping
TI For the depolarization of linearly polarized light by smoke particles
SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
LA English
DT Article
DE Linearly polarized light; Depolarization ratio; Particle
characterization; Smoke aerosol
ID ABSORBING BOUNDARY-CONDITION; TIME-DOMAIN SOLUTION; SCATTERING; SOOT;
ABSORPTION
AB The CALIPSO satellite mission consistently measures volume (including molecule and particulate) light depolarization ratio of similar to 2% for smoke, compared to similar to 1% for marine aerosols and similar to 15% for dust. The observed similar to 2% smoke depolarization ratio comes primarily from the nonspherical habits of particles in the smoke at certain particle sizes. In this study, the depolarization of linearly polarized light by small sphere aggregates and irregular Gaussian-shaped particles is studied, to reveal the physics between the depolarization of linearly polarized light and smoke aerosol shape and size. It is found that the depolarization ratio curves of Gaussian-deformed spheres are very similar to sphere aggregates in terms of scattering-angle dependence and particle size parameters when particle size parameter is smaller than 1.0 pi. This demonstrates that small randomly oriented nonspherical particles have some common depolarization properties as functions of scattering angle and size parameter. This may be very useful information for characterization and active remote sensing of smoke particles using polarized light. We also show that the depolarization ratio from the CALIPSO measurements could be used to derive smoke aerosol particle size. From the calculation results for light depolarization ratio by Gaussian-shaped smoke particles and the CALIPSO-measured light depolarization ratio of similar to 2% for smoke, the mean particle size of South-African smoke is estimated to be about half of the 532 nm wavelength of the CALIPSO lidar. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Sun, Wenbo; Liu, Zhaoyan; Jin, Zhonghai] Sci Syst & Applicat Inc, Hampton, VA 23666 USA.
[Videen, Gorden] USA, Res Lab, Adelphi, MD 20783 USA.
[Fu, Qiang] Univ Washington, Seattle, WA 98195 USA.
[Muinonen, Karri] Univ Helsinki, FIN-00014 Helsinki, Finland.
[Sun, Wenbo; Winker, David M.; Lukashin, Constantine; Lin, Bing] NASA, Langley Res Ctr, Hampton, VA 23681 USA.
[Huang, Jianping] Lanzhou Univ, Lanzhou 730000, Peoples R China.
RP Sun, WB (reprint author), NASA, Langley Res Ctr, Mail Stop 420, Hampton, VA 23681 USA.
EM wenbo.sun-1@nasa.gov
RI Liu, Zhaoyan/B-1783-2010; Richards, Amber/K-8203-2015
OI Liu, Zhaoyan/0000-0003-4996-5738;
FU NASA [09-GLORY09-0027]; NASA CLARREO mission
FX This work was supported by NASA Glory fund 09-GLORY09-0027 and partially
by NASA CLARREO mission. The authors thank Michael I. Mishchenko, Hal B.
Maring, Bruce A. Wielicki, and Dave F. Young for their support on this
work.
NR 23
TC 11
Z9 12
U1 2
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4073
J9 J QUANT SPECTROSC RA
JI J. Quant. Spectrosc. Radiat. Transf.
PD JUN
PY 2013
VL 122
SI SI
BP 233
EP 237
DI 10.1016/j.jqsrt.2012.03.031
PG 5
WC Optics; Spectroscopy
SC Optics; Spectroscopy
GA 142VN
UT WOS:000318825800023
ER
PT J
AU von Elten, K
Sawyer, T
Lentz-Kapua, S
Kanis, A
Studer, M
AF von Elten, Kelley
Sawyer, Taylor
Lentz-Kapua, Sarah
Kanis, Adam
Studer, Matthew
TI A Case of Wolf-Hirschhorn Syndrome and Hypoplastic Left Heart Syndrome
SO PEDIATRIC CARDIOLOGY
LA English
DT Article
DE Hypoplastic left heart; Chromosome 4
ID FEATURES
AB Wolf-Hirschhorn Syndrome (WHS) is a genetic syndrome that includes a typical facial appearance, mental retardation, growth delay, seizures, and congenital cardiac defects. A deletion of the terminal band of the short arm of chromosome 4, with a breakpoint at the 4p15 to 4p16 region, is the most common genetic mutation causing WHS. Congenital heart disease associated with WHS typically includes atrial and ventricular septal defects, though there are a few case reports of associated complex congenital heart disease. Here we report a case of an infant with a large 4p deletion, with a breakpoint at the 4p12 region, and hypoplasic left heart syndrome. We discuss a possible link between the size of the chromosomal deletion in WHS and the severity of the cardiac defect.
C1 [von Elten, Kelley; Sawyer, Taylor; Lentz-Kapua, Sarah; Kanis, Adam; Studer, Matthew] Tripler Army Med Ctr, Dept Pediat, MCHK PE, Honolulu, HI 96859 USA.
RP von Elten, K (reprint author), Tripler Army Med Ctr, Dept Pediat, MCHK PE, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM Kelley.vonelten@gmail.com
NR 7
TC 1
Z9 1
U1 1
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0172-0643
J9 PEDIATR CARDIOL
JI Pediatr. Cardiol.
PD JUN
PY 2013
VL 34
IS 5
BP 1244
EP 1246
DI 10.1007/s00246-012-0367-8
PG 3
WC Cardiac & Cardiovascular Systems; Pediatrics
SC Cardiovascular System & Cardiology; Pediatrics
GA 143MH
UT WOS:000318871100025
PM 22639003
ER
PT J
AU Barsoumian, A
Calvano, T
Markelz, AE
Cassidy, R
Murray, CK
Beckius, ML
Mende, K
Akers, KS
AF Barsoumian, Alice
Calvano, Tatjana
Markelz, Ana E.
Cassidy, Ryan
Murray, Clinton K.
Beckius, Miriam L.
Mende, Katrin
Akers, Kevin S.
TI Variations of CHROMagar Acinetobacter to detect imipenem-resistant
Acinetobacter baumannii-calcoaceticus complex
SO SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE Acinetobacter baumannii-calcoaceticus complex; MDR; CHROMagar;
carbapenem
ID LACTAMASE-PRODUCING ENTEROBACTERIACEAE; SUSCEPTIBILITY TESTING ERRORS;
CRITICALLY-ILL PATIENTS; STAPHYLOCOCCUS-AUREUS; SELECTIVE MEDIUM; MRSA
II; SPECIMENS; EPIDEMIOLOGY; INFECTION; AGAR
AB Background: Acinetobacter baumannii-calcoaceticus complex (ABC) isolates are often multidrug-resistant, including to carbapenems. Chromogenic media can facilitate the rapid detection of Gram-negative bacteria, often with the addition of supplements to a base chromogenic medium to detect resistance. We examined various combinations of available media to detect imipenem resistance among 107 ABC clinical isolates. Methods: CHROMagar Orientation, CHROMagar KPC, and CHROMagar Acinetobacter, by itself, with Acinetobacter supplement, with KPC supplement, or CHROMagar Acinetobacter with increasing concentrations (1, 2.5, and 5 ml/l) of a new CR102 supplement, were examined. Results: Sensitivity for the detection of isolates was high (> 98%) for all formulations. Specificity was high for CHROMagar Acinetobacter with 2.5 ml/l and 5 ml/l of the CR102 supplement, at 95.3% and 97.7%, respectively, with positive predictive values of 97% and 98.5%. Negative predictive values of these 2 formulations were 100%. Conclusions: CHROMagar Acinetobacter with the addition of the CR102 supplement at 2.5 ml/l and 5ml/l is highly sensitive and specific for the detection of imipenem-resistant ABC, and may be useful for the rapid detection of imipenem-resistant ABC in clinical samples.
C1 [Barsoumian, Alice; Calvano, Tatjana; Markelz, Ana E.; Murray, Clinton K.; Mende, Katrin; Akers, Kevin S.] San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX USA.
[Cassidy, Ryan] Univ Texas Austin, Austin, TX 78712 USA.
[Murray, Clinton K.; Akers, Kevin S.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Beckius, Miriam L.] San Antonio Mil Med Ctr, Dept Clin Invest, Ft Sam Houston, TX USA.
[Mende, Katrin] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
RP Akers, KS (reprint author), Brooke Army Med Ctr, San Antonio Mil Med Ctr, MCHE MDI, Infect Dis Serv, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM kevin.akers@us.army.mil
RI Valle, Ruben/A-7512-2013;
OI Cassidy, Ryan/0000-0003-4100-0413
FU US Armed Forces Health Surveillance Center; Division of Global and
Emerging Infections Surveillance and Response System Operations;
Infectious Diseases Clinical Research Program
FX The authors gratefully acknowledge the support of the US Armed Forces
Health Surveillance Center, Division of Global and Emerging Infections
Surveillance and Response System Operations, and the Infectious Diseases
Clinical Research Program.
NR 28
TC 4
Z9 4
U1 1
U2 7
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0036-5548
J9 SCAND J INFECT DIS
JI Scand. J. Infect. Dis.
PD JUN
PY 2013
VL 45
IS 6
BP 446
EP 452
DI 10.3109/00365548.2013.759270
PG 7
WC Infectious Diseases
SC Infectious Diseases
GA 144LI
UT WOS:000318940400005
PM 23317168
ER
PT J
AU Cunningham, D
Everton, S
Wilson, G
Padilla, C
Zimmerman, D
AF Cunningham, Dan
Everton, Sean
Wilson, Greg
Padilla, Carlos
Zimmerman, Doug
TI Brokers and Key Players in the Internationalization of the FARC
SO STUDIES IN CONFLICT & TERRORISM
LA English
DT Article
ID COMMUNITY STRUCTURE; NETWORKS; CENTRALITY
AB The Fuerzas Armadas Revolucionarias de Colombia (Revolutionary Armed Forces of ColombiaFARC) was originally founded to protect Colombian peasants from harsh landowner policies in exchange for food and supplies. Over time, it has evolved into an internationally connected, narco-trafficking organization that displays little concern for the peasants it once vowed to protect. In recent years, Colombian authorities have become more adept at countering the FARC, forcing it to operate increasingly outside of Colombia. The FARC's transformation from a local insurgency into an internationally connected one is the focus of this article. Using social network analysis it identifies key leaders who are tied to this transformation and discusses implications concerning the FARC's future.
C1 [Cunningham, Dan; Everton, Sean; Wilson, Greg] USN, Postgrad Sch, Def Anal Dept, Monterey, CA 93943 USA.
[Zimmerman, Doug] USA, Washington, DC USA.
RP Everton, S (reprint author), USN, Postgrad Sch, Codirector Core Lab, Def Anal Dept, 589 Dyer Rd,Root Hall 203, Monterey, CA 93943 USA.
EM sfeverto@nps.edu
NR 60
TC 1
Z9 1
U1 1
U2 15
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1057-610X
EI 1521-0731
J9 STUD CONFL TERROR
JI Stud. Confl. Terror.
PD JUN 1
PY 2013
VL 36
IS 6
BP 477
EP 502
DI 10.1080/1057610X.2013.784603
PG 26
WC International Relations; Political Science
SC International Relations; Government & Law
GA 145TM
UT WOS:000319040700003
ER
PT J
AU Povich, TJ
Dawson, CN
Farthing, MW
Kees, CE
AF Povich, T. J.
Dawson, C. N.
Farthing, M. W.
Kees, C. E.
TI Finite element methods for variable density flow and solute transport
SO COMPUTATIONAL GEOSCIENCES
LA English
DT Article
DE Saltwater intrusion; Variable density; Stabilized FEM; Velocity
post-processing
ID COUPLED GROUNDWATER-FLOW; POROUS-MEDIA; SIMULATION; BENCHMARK; MODELS;
CONVECTION; HENRY; BRINE
AB Saltwater intrusion into coastal freshwater aquifers is an ongoing problem that will continue to impact coastal freshwater resources as coastal populations increase. To effectively model saltwater intrusion, the impacts of increased salt content on fluid density must be accounted for to properly model saltwater/freshwater transition zones and sharp interfaces. We present a model for variable density fluid flow and solute transport where a conforming finite element method discretization with a locally conservative velocity post-processing method is used for the flow model and the transport equation is discretized using a variational multiscale stabilized conforming finite element method. This formulation provides a consistent velocity and performs well even in advection-dominated problems that can occur in saltwater intrusion modeling. The physical model is presented as well as the formulation of the numerical model and solution methods. The model is tested against several 2-D and 3-D numerical and experimental benchmark problems, and the results are presented to verify the code.
C1 [Povich, T. J.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA.
[Dawson, C. N.] Univ Texas Austin, Computat Hydraul Grp, Austin, TX 78712 USA.
[Farthing, M. W.; Kees, C. E.] USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA.
RP Povich, TJ (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA.
EM Timothy.Povich@usma.edu
FU US DoD User Productivity Enhancement, Technology Transfer, and Training
Program [PP-EQM-KY02-0001-P3]; Omar N. Bradley Foundation Fellowship
FX This research was funded by the US DoD User Productivity Enhancement,
Technology Transfer, and Training Program (contract PP-EQM-KY02-0001-P3,
"Saltwater Intrusion and Density Driven Flow Modeling in ADH"). The
first author was also partially funded with the support of an Omar N.
Bradley Foundation Fellowship. Permission was granted by the Chief of
Engineers to publish this information.
NR 43
TC 7
Z9 7
U1 0
U2 13
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1420-0597
J9 COMPUTAT GEOSCI
JI Comput. Geosci.
PD JUN
PY 2013
VL 17
IS 3
SI SI
BP 529
EP 549
DI 10.1007/s10596-012-9330-2
PG 21
WC Computer Science, Interdisciplinary Applications; Geosciences,
Multidisciplinary
SC Computer Science; Geology
GA 138IH
UT WOS:000318501700008
ER
PT J
AU Satapathi, S
Kokil, A
Venkatraman, BH
Li, L
Venkataraman, D
Kumar, J
AF Satapathi, Soumitra
Kokil, Akshay
Venkatraman, B. Harihara
Li, Lian
Venkataraman, Dhandapani
Kumar, Jayant
TI Sensitive Detection of Nitroaromatics With Colloidal Conjugated Polymer
Nanoparticles
SO IEEE SENSORS JOURNAL
LA English
DT Article
DE DNT; fluorescence quenching; nanoparticle; polythiophene; surfactant;
TNT
ID SOLUBLE POLYTHIOPHENE; FLUORESCENCE; TNT; EXPLOSIVES; SENSORS
AB We observe more than two orders of magnitude enhancement of fluorescence quenching in colloidal conjugated polymer nanoparticles by nitroaromatic analytes compared to solution of the same polymer in organic solvents. This observation is surprising as the quantum efficiency of fluorescence of the polymer solution is significantly higher. The colloidal nanoparticle dispersions of substituted polythiophene derivative are fabricated by the surfactant-assisted mini-emulsion technique. Stern-Volmer constants are determined using both one-photon and two-photon excitation methods. We believe strong analyte-nanoparticle interaction results in the large value of the Stern-Volmer constants measured. The nanoparticle-based sensor described here is suitable for developing a field-based sensory device for detecting a broad class of nitroaromatics in solution.
C1 [Satapathi, Soumitra; Kokil, Akshay; Kumar, Jayant] Univ Massachusetts Lowell, Ctr Adv Mat, Lowell, MA 01854 USA.
[Satapathi, Soumitra; Kumar, Jayant] Univ Massachusetts Lowell, Dept Phys, Lowell, MA 01854 USA.
[Venkatraman, B. Harihara; Venkataraman, Dhandapani] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA.
[Li, Lian] USA, Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA.
RP Satapathi, S (reprint author), Univ Massachusetts Lowell, Ctr Adv Mat, Lowell, MA 01854 USA.
EM soumitrasatapathi@gmail.com; akshay_kokil@uml.edu; harihvr@gmail.com;
lian_li@uml.edu; dv@chem.umass.edu; jayant_kumar@uml.edu
RI Venkataraman, Dhandapani/A-8226-2008; Kokil, Akshay/A-6886-2009
OI Venkataraman, Dhandapani/0000-0003-2906-0579; Kokil,
Akshay/0000-0002-8295-2878
FU Army Research Lab; National Science Foundation
FX This work was supported in part by the Army Research Lab and National
Science Foundation. The associate editor coordinating the review of this
paper and approving it for publication was Prof. Yu-Cheng Lin.
NR 19
TC 6
Z9 6
U1 4
U2 51
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1530-437X
J9 IEEE SENS J
JI IEEE Sens. J.
PD JUN
PY 2013
VL 13
IS 6
BP 2329
EP 2333
DI 10.1109/JSEN.2013.2252237
PG 5
WC Engineering, Electrical & Electronic; Instruments & Instrumentation;
Physics, Applied
SC Engineering; Instruments & Instrumentation; Physics
GA 141EB
UT WOS:000318707300019
ER
PT J
AU Unnikrishnan, VU
Unnikrishnan, GU
Reddy, JN
Rostam-Abadi, F
AF Unnikrishnan, V. U.
Unnikrishnan, G. U.
Reddy, J. N.
Rostam-Abadi, F.
TI Multiscale analysis of impact mitigation in soft tissues using nanotube
reinforced composites
SO INTERNATIONAL JOURNAL OF MECHANICS AND MATERIALS IN DESIGN
LA English
DT Article
DE Nanocomposite; Shrapnel; Impact; Molecular dynamics; Poroelastic
ID MOLECULAR-DYNAMICS SIMULATIONS; SHORT-FIBER COMPOSITES; TRABECULAR BONE;
ORIENTATION; NANOCOMPOSITES; UNCERTAINTIES; MECHANICS; CONTINUUM;
BEHAVIOR; POROSITY
AB Kinetic energy of an inert projectile or its fragment can cause considerable damage to soft tissues and cause debilitating injuries or fatalities. The primary aim of threat mitigation due to kinetic energy dissipation is to provide adequate protection against projectiles or fragments in the form of body shields. Recently, novel nanocomposite materials reinforced with nanotubes are used as shields to protect the soft-tissues during impact. Soft tissues constitute an important part of human body performing various mechanical functions and a deep understanding of the behavior of soft tissue is required to characterize its response to external mechanical forces. Soft tissues are non-homogenous anisotropic materials, and their properties are dependent on the the physiological structure. In this paper, a multiscale homogenization-based analysis of the constituent properties of soft tissues and underlying endoskeleton are developed for impact mitigation using nanotube-reinforced composite shields.
C1 [Unnikrishnan, V. U.] Univ Alabama, Dept Aerosp Engn & Mech, Tuscaloosa, AL 35487 USA.
[Unnikrishnan, G. U.] Boston Univ, Dept Mech Engn, Boston, MA 02445 USA.
[Reddy, J. N.] Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA.
[Rostam-Abadi, F.] USA, Tank Automot & Armaments Command, AMSTA TR R, Warren, MI 48397 USA.
RP Unnikrishnan, VU (reprint author), Univ Alabama, Dept Aerosp Engn & Mech, Tuscaloosa, AL 35487 USA.
EM vunnikrishnan@ua.edu
RI Reddy, Junuthula/D-7737-2013
OI Reddy, Junuthula/0000-0002-9739-1639
NR 38
TC 1
Z9 1
U1 1
U2 16
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1569-1713
J9 INT J MECH MATER DES
JI Int. J. Mech. Mater. Des.
PD JUN
PY 2013
VL 9
IS 2
SI SI
BP 181
EP 189
DI 10.1007/s10999-013-9221-2
PG 9
WC Engineering, Civil; Engineering, Mechanical; Materials Science,
Multidisciplinary; Mechanics
SC Engineering; Materials Science; Mechanics
GA 140LT
UT WOS:000318656300006
ER
PT J
AU Hromadka, TV
Jaye, M
Phillips, M
Hromadka, T
Phillips, D
AF Hromadka, T. V., II
Jaye, M.
Phillips, M.
Hromadka, T., III
Phillips, D.
TI Mathematical Model of Cryospheric Response to Climate Changes
SO JOURNAL OF COLD REGIONS ENGINEERING
LA English
DT Article
DE Global climate change; Cryosphere; Mathematical model; Phase change;
Differential equation model
ID VOSTOK ICE-CORE; FREEZING FRONTS; SOIL; HEAT; SEGREGATION; RECORD
AB This paper focuses on the development of simplified mathematical models of the cryosphere which may be useful in further understanding possible global climate change impacts and in further assessing future impacts captured by global circulation models (GCMs). The mathematical models developed by leveraging the dominating effects of freezing and thawing within the cryosphere to simplify the relevant heat transport equations are tractable to direct solution or numerical modeling. In this paper, the heat forcing function is assumed to be a linear transformation of temperature (assumed to be represented by proxy realizations). The output from the governing mathematical model is total ice volume of the cryosphere. The basic mathematical model provides information as a systems modeling approach that includes sufficient detail to explain ice volume given the estimation of the heat forcing function. A comparison between modeling results in the estimation of ice volume versus ice volume estimates developed from use of proxy data are shown in the demonstration problems presented.
C1 [Hromadka, T. V., II; Phillips, M.; Phillips, D.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA.
[Jaye, M.] USN, Dept Def Anal, Postgrad Sch, Monterey, CA 93943 USA.
[Hromadka, T., III] Univ Calif San Diego, Dept Comp Sci, La Jolla, CA 92093 USA.
RP Hromadka, TV (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA.
EM ted@phdphdphd.com
FU United States Military Academy, West Point, New York, Department of
Mathematical Sciences; Naval Post Graduate School, Monterey, California,
Department of Defense Analysis
FX Acknowledgements are paid to the United States Military Academy, West
Point, New York, Department of Mathematical Sciences and the Naval Post
Graduate School, Monterey, California, Department of Defense Analysis
for their support to the authors during this research. Also acknowledged
are the several individuals who have participated in particular tasks in
developing this paper including, but by no means limited to, Rene Perez,
Laura Hromadka, Bethany Espinosa, and Michael Barton.
NR 44
TC 1
Z9 1
U1 2
U2 11
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0887-381X
J9 J COLD REG ENG
JI J. Cold Reg. Eng.
PD JUN
PY 2013
VL 27
IS 2
BP 67
EP 93
DI 10.1061/(ASCE)CR.1943-5495.0000053
PG 27
WC Engineering, Environmental; Engineering, Civil; Geosciences,
Multidisciplinary
SC Engineering; Geology
GA 139GE
UT WOS:000318569200002
ER
PT J
AU Finn, S
AF Finn, Stephen
TI Using Psychology Experiments in Introductory Philosophy Courses
SO TEACHING PHILOSOPHY
LA English
DT Article
AB In this paper, I describe a variety of psychology experiments that may be used in introductory philosophy courses not only to grab students' attention, but also to generate philosophical discussion or to make a philosophical point. The experiments attempt to capture students' interest in two ways: (1) by posing interesting challenges to students, thereby provoking more active thought in class and (2) by doing something different, thereby increasing attention that naturally follows from change. Although the experiments are psychology experiments, they may still be used to emphasize certain philosophical points or to introduce philosophical topics. The philosophical import of each experiment is quite general, so these exercises are most appropriate for students enrolled in introductory courses.
C1 [Finn, Stephen] US Mil Acad, West Point, NY 10996 USA.
[Finn, Stephen] US Mil Acad, Ctr Fac Excellence, West Point, NY USA.
RP Finn, S (reprint author), US Mil Acad, West Point, NY 10996 USA.
EM stephen.finn@usma.edu
NR 9
TC 0
Z9 0
U1 0
U2 2
PU PHILOSOPHY DOCUMENTATION CENTER
PI CHARLOTTESVILLE
PA PO BOX 7147, CHARLOTTESVILLE, VA 22906-7147 USA
SN 0145-5788
J9 TEACH PHILOS
JI Teach Philos.
PD JUN
PY 2013
VL 36
IS 2
BP 125
EP 135
DI 10.5840/teachphil201336217
PG 11
WC Philosophy
SC Philosophy
GA 141UP
UT WOS:000318752300002
ER
PT J
AU Bandera, BC
Strode, M
Rice, R
AF Bandera, Bradley C.
Strode, Matthew
Rice, Robert
TI Nonoperative Management of Complicated Diverticulitis with
Extradigestive Air
SO AMERICAN SURGEON
LA English
DT Article
C1 [Bandera, Bradley C.; Strode, Matthew; Rice, Robert] Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, Ft Gordon, GA USA.
RP Bandera, BC (reprint author), Dwight D Eisenhower Army Med Ctr, 300 Hosp Rd, Augusta, GA 30905 USA.
EM b.bandera07@comcast.net
NR 2
TC 1
Z9 1
U1 0
U2 0
PU SOUTHEASTERN SURGICAL CONGRESS
PI CUMMING
PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD JUN
PY 2013
VL 79
IS 6
BP E243
EP E245
PG 3
WC Surgery
SC Surgery
GA AI6DY
UT WOS:000336962000012
PM 23711261
ER
PT J
AU Bioucas-Dias, JM
Plaza, A
Camps-Valls, G
Scheunders, P
Nasrabadi, NM
Chanussot, J
AF Bioucas-Dias, Jose M.
Plaza, Antonio
Camps-Valls, Gustavo
Scheunders, Paul
Nasrabadi, Nasser M.
Chanussot, Jocelyn
TI Hyperspectral Remote Sensing Data Analysis and Future Challenges
SO IEEE GEOSCIENCE AND REMOTE SENSING MAGAZINE
LA English
DT Article
AB Hyperspectral remote sensing technology has advanced significantly in the past two decades. Current sensors onboard airborne and spaceborne platforms cover large areas of the Earth surface with unprecedented spectral, spatial, and temporal resolutions. These characteristics enable a myriad of applications requiring fine identification of materials or estimation of physical parameters. Very often, these applications rely on sophisticated and complex data analysis methods. The sources of difficulties are, namely, the high dimensionality and size of the hyperspectral data, the spectral mixing (linear and nonlinear), and the degradation mechanisms associated to the measurement process such as noise and atmospheric effects. This paper presents a tutorial/overview cross section of some relevant hyperspectral data analysis methods and algorithms, organized in six main topics: data fusion, unmixing, classification, target detection, physical parameter retrieval, and fast computing. In all topics, we describe the state-of-the-art, provide illustrative examples, and point to future challenges and research directions.
C1 [Bioucas-Dias, Jose M.] Inst Super Tecn, Inst Telecomunicacoes, P-10491 Lisbon, Portugal.
[Plaza, Antonio] Univ Extremadura, Escuela Politecn Caceres, Dept Technol Comp & Commun, Hyperspectral Comp Lab, Caceres 10003, Spain.
[Camps-Valls, Gustavo] Univ Valencia, Image Proc Lab, E-46980 Paterna, Valencia, Spain.
[Scheunders, Paul] Univ Antwerp, Vis Lab, Dept Phys, iMinds, B-2610 Antwerp, Belgium.
[Nasrabadi, Nasser M.] US Army Res Lab, Adelphi, MD 20783 USA.
[Chanussot, Jocelyn] Grenoble Inst Technol, GIPSA Lab, Grenoble, France.
RP Bioucas-Dias, JM (reprint author), Inst Super Tecn, Inst Telecomunicacoes, P-10491 Lisbon, Portugal.
EM bioucas@lx.it.pt; aplaza@unex.es; gustavo.camps@uv.es;
paul.scheunders@ua.ac.be; nasser.m.nasrabadi.civ@mail.mil;
jocelyn.chanussot@gipsa-lab.grenoble-inp.fr
RI Bioucas-Dias, Jose/C-5479-2009
NR 187
TC 60
Z9 74
U1 7
U2 14
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 2168-6831
J9 IEEE GEOSC REM SEN M
JI IEEE Geosci. Remote Sens. Mag.
PD JUN
PY 2013
VL 1
IS 2
BP 6
EP 36
DI 10.1109/MGRS.2013.2244672
PG 31
WC Geochemistry & Geophysics; Remote Sensing; Imaging Science &
Photographic Technology
SC Geochemistry & Geophysics; Remote Sensing; Imaging Science &
Photographic Technology
GA V45AS
UT WOS:000209790100003
ER
PT J
AU Curtis, TM
Howard, A
Gerlach, BD
Brennan, LM
Widder, MW
van der Schalie, WH
Vo, NTK
Bols, NC
AF Curtis, T. M.
Howard, A.
Gerlach, B. D.
Brennan, L. M.
Widder, M. W.
van der Schalie, W. H.
Vo, N. T. K.
Bols, N. C.
TI Suitability of Invertebrate and Vertebrate Cells in a Portable
Impedance-based Toxicity Sensor: Temperature Mediated Impacts on
Long-term Survival
SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
LA English
DT Meeting Abstract
C1 [Curtis, T. M.; Howard, A.; Gerlach, B. D.] SUNY Coll Cortland, Dept Biol Sci, Cortland, NY 13045 USA.
[Brennan, L. M.; Widder, M. W.; van der Schalie, W. H.] US Army, Ctr Environm Hlth Res, Ft Detrick, MD USA.
[Vo, N. T. K.; Bols, N. C.] Univ Waterloo, Dept Biol, Waterloo, ON N2L 3G1, Canada.
EM Theresa.curtis@cortland.edu
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1071-2690
EI 1543-706X
J9 IN VITRO CELL DEV-AN
JI In Vitro Cell. Dev. Biol.-Anim.
PD JUN
PY 2013
VL 49
SU 1
MA A-2002
BP S41
EP S41
PG 1
WC Cell Biology; Developmental Biology
SC Cell Biology; Developmental Biology
GA V41LL
UT WOS:000209547600103
ER
PT J
AU Shah, NR
Bieniarz, MC
Basra, SS
Paisley, RD
Loyalka, P
Gregoric, ID
Mann, DL
Kar, B
AF Shah, Nishant R.
Bieniarz, Mark C.
Basra, Sukhdeep S.
Paisley, Robert D.
Loyalka, Pranav
Gregoric, Igor D.
Mann, Douglas L.
Kar, Biswajit
TI Serum Biomarkers in Severe Refractory Cardiogenic Shock
SO JACC-HEART FAILURE
LA English
DT Article
DE biomarkers; cardiogenic shock; heart failure; percutaneous left
ventricular assist device
AB Objectives The aim of this study was to characterize levels of serum biomarkers in patients with severe refractory cardiogenic shock (SRCS) and to document temporal changes in these levels during restoration of circulation.
Background Patients with SRCS have been challenging to study because of their rapidly changing clinical condition while undergoing multiple simultaneous interventions.
Methods Twenty-one patients with SRCS received circulatory support via a percutaneously implanted ventricular assist device (PVAD). Serum samples obtained prior to PVAD support initiation, at 24 h of PVAD support, and at 7 days of PVAD support were assayed for B-type natriuretic peptide (BNP), high-sensitivity C-reactive protein (hsCRP), soluble tumor necrosis factor receptor-1 (sTNFR1), soluble Fas (sFas), soluble Fas ligand (sFasL), endothelin-1, and procollagen III N-terminal peptide (PIIINP). Baseline biomarker levels were qualitatively compared to reference values; levels at 24 h of PVAD support and at 7 days of PVAD support were compared to baseline using 2-tailed Wilcoxon matched pair signed rank tests with Bonferroni correction for multiple comparisons.
Results These patients with SRCS had elevated serum levels of BNP, hsCRP, sTNFR1, endothelin-1, and PIIINP. Ventricular unloading and restoration of circulation via PVAD support in patients with SRCS were associated with reductions in serum BNP, sFas, and endothelin-1 levels and increases in serum sFasL and PIIINP levels.
Conclusions This study characterizes several important baseline serum biomarker levels in patients with SRCS and introduces a novel PVAD-based protocol with the potential to "reverse"-model the pathophysiology of cardiogenic shock. (c) 2013 by the American College of Cardiology Foundation
C1 [Shah, Nishant R.] Baylor Coll Med, Texas Heart Inst, Houston, TX 77030 USA.
[Bieniarz, Mark C.] New Mexico Heart Inst, Albuquerque, NM USA.
[Basra, Sukhdeep S.] Baylor Coll Med, Houston, TX 77030 USA.
[Paisley, Robert D.] US Army, Joint Base Elmendorf Richardson, Infantry Airborne 3 509, Richardson, AK USA.
[Loyalka, Pranav; Gregoric, Igor D.; Kar, Biswajit] Univ Texas Hlth Sci Ctr Houston, Texas Heart Inst, Houston, TX 77030 USA.
[Mann, Douglas L.] Washington Univ, Sch Med, St Louis, MO USA.
RP Kar, B (reprint author), Univ Texas Hlth Sci Ctr Houston, Ctr Adv Heart Failure, 6410 Fannin St,Suite 920, Houston, TX 77030 USA.
EM biswajit.kar@uth.tmc.edu
OI Mann, Douglas /0000-0002-2516-0145
NR 22
TC 5
Z9 5
U1 0
U2 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2213-1779
EI 2213-1787
J9 JACC-HEART FAIL
JI JACC-Heart Fail.
PD JUN
PY 2013
VL 1
IS 3
BP 200
EP 206
DI 10.1016/j.jchf.2013.03.002
PG 7
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA V41GU
UT WOS:000209535500003
PM 24621870
ER
PT J
AU Sutorik, AC
Cooper, C
Green, MD
Wolfenstine, J
Gilde, G
AF Sutorik, A. C.
Cooper, C.
Green, M. D.
Wolfenstine, J.
Gilde, G.
TI The Effect of Different La-Containing Starting Materials on the
Synthesis, Sintering, and Li+-Conductivity of Li3xLa2/3-xTiO3
SO JOURNAL OF CERAMIC SCIENCE AND TECHNOLOGY
LA English
DT Article
DE Li+-conducting ceramic; Li-air battery; ceramic electrolyte; lithium
lanthanum titanate
AB Li3xLa2/3-xTiO3 is a promising ceramic electrolyte for high energy density Li-batteries. The material is usually prepared from solid state reactions between Li2CO3, La2O3, and TiO2, but the hydroscopic nature of La2O3 leads to inconsistencies in formulation and synthetic outcome which can impact the phase formation and corresponding Li-conductivity of the final ceramic. To address this issue, La carbonate and hydroxides have been evaluated as starting materials for solid state synthesis of Li3xLa2/3-xTiO3 powders and sintered ceramic. The different La-starting materials are all prepared from precipitation reaction as high surface area powders. These are characterized for phase, particle size, particle morphology, and ceramic yield (by thermal gravimetric analysis). The La starting materials are then mixed with the desired stoichiometric amounts of Li2CO3 and TiO2. The mixtures are calcined at 1100 degrees C for 1 h before being pressed into green parts and sintered at either 1200 or 1300 degrees C for 6 h. Under nearly all conditions investigated, the formulations using the La-carbonate-based starting material lead to ceramics with the highest bulk density, the highest degree of cubic superstructure formation, and the highest lattice Lit-conductivity. Total conductivity, however, appears largely insensitive to the La starting material used.
C1 [Sutorik, A. C.; Cooper, C.; Green, M. D.; Gilde, G.] US Army, Res Lab, RDRL WMM E, Aberdeen Proving Ground, MD 21005 USA.
[Wolfenstine, J.] US Army, Res Lab, RDRL SED C, Adelphi, MD 20783 USA.
RP Sutorik, AC (reprint author), US Army, Res Lab, RDRL WMM E, Bldg 4600, Aberdeen Proving Ground, MD 21005 USA.
EM anthony.sutorik1@us.army.mil
NR 27
TC 3
Z9 3
U1 4
U2 13
PU GOLLER VERLAG GMBH
PI BADEN BADEN
PA ASCHMATTSTRASSE 8, D-76532 BADEN BADEN, GERMANY
SN 2190-9385
J9 J CERAM SCI TECHNOL
JI J. Ceram. Sci. Technol.
PD JUN
PY 2013
VL 4
IS 2
SI SI
BP 59
EP 68
DI 10.4416/JCST2012-00035
PG 10
WC Materials Science, Ceramics
SC Materials Science
GA V36FY
UT WOS:000209199600002
ER
PT J
AU Honey, JR
AF Honey, James R.
TI The Army Selected Reserve Dental Readiness System: Overview, Assessment,
and Recommendations
SO MILITARY MEDICINE
LA English
DT Article
AB The Army Selected Reserve Dental Readiness System (ASDRS) is a key dental program directed by the Assistant Secretary of the Army (Manpower & Reserve Affairs) starting in fiscal year 09. The Army National Guard and Army Reserve have steadily implemented ASDRS over the past 3 years as a means to improve the historically abysmal dental readiness of the Army Reserve Component (RC). Dental readiness is essential for sustaining an Army RC Operational Force. ASDRS is a tool for RC commanders to provide contract dental readiness care in support of over 558 thousand nonmobilized Selected Reserve Citizen-Soldiers dispersed throughout the 54 states and U.S. territories, at home station before alert, and if necessary after alert (throughout the Army force generation cycle). This article examines the status of ASDRS implementation, assesses its effectiveness in improving Army RC Dental Readiness, and provides Army leadership recommendations regarding the following focus areas: (1) command emphasis, (2) program execution, and (3) synergy with the Military Health System and Department of Veterans Affairs.
C1 US Army Reserve Command, Army Reserve Surg Off, Ft Bragg, NC 28310 USA.
RP Honey, JR (reprint author), US Army Reserve Command, Army Reserve Surg Off, 4710 Knox St Bldg 8-1808, Ft Bragg, NC 28310 USA.
NR 17
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JUN
PY 2013
VL 178
IS 6
BP 607
EP 618
DI 10.7205/MILMED-D-12-00445
PG 12
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7TZ
UT WOS:000340805200004
PM 23756066
ER
PT J
AU Gubata, ME
Oetting, AA
Niebuhr, DW
Cowan, DN
AF Gubata, Marlene E.
Oetting, Alexis A.
Niebuhr, David W.
Cowan, David N.
TI Accession Medical Waivers and Deployment Duration in the US Army
SO MILITARY MEDICINE
LA English
DT Article
ID MILITARY ENLISTEES; SURVIVAL ANALYSIS; RISK-FACTORS; ATTRITION;
DISCHARGE; RECRUITS; SERVICE; HOSPITALIZATION; STANDARDS; INJURY
AB To examine the performance of active duty U.S. Army personnel with accession medical waivers during combat deployments, the deployment duration and likelihood of early return from theater for medically waived (n = 18,093) and medically qualified (77 = 250,209) personnel deploying between September 2001 and March 2011 were determined. The mean and median deployment duration for waived men (309.4 +/- 107.5 and 346) and for waived women (291.8 +/- 115.3 and 341) was not shorter than for medically qualified men (304.6 +/- 112.1 and 346) and women (289.5 +/- 116.3 and 337). When adjusted for other accession factors in a multivariate linear regression model, neither waived men (p = 1.00) nor women (p = 0.7713) had significantly shorter deployments. In a case-control analysis, 24,369 men and 3,094 women were defined as having a short deployment. Multivariate logistic regression found that medically waived men (odds ratio [OR] = 0.87, 95% confidence interval [CI] = 0.82-0.92) and women (OR = 1.02, 95% CI = 0.87-1.19) were not more likely to have shorter deployments compared to medically qualified individuals. These findings show that those with an accession medical waiver were not more likely to have shorter deployments or more likely to return early from deployment than those without waivers.
C1 [Gubata, Marlene E.; Oetting, Alexis A.; Niebuhr, David W.; Cowan, David N.] Walter Reed Army Inst Res, Prevent Med Branch, Dept Epidemiol, Silver Spring, MD 20910 USA.
[Oetting, Alexis A.; Cowan, David N.] Allied Technol Grp Inc, Rockville, MD 20850 USA.
RP Gubata, ME (reprint author), Walter Reed Army Inst Res, Prevent Med Branch, Dept Epidemiol, 503 Robert Grant Rd, Silver Spring, MD 20910 USA.
FU Defense Health Program
FX This work was funded by the Defense Health Program.
NR 27
TC 1
Z9 1
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JUN
PY 2013
VL 178
IS 6
BP 625
EP 630
DI 10.7205/MILMED-D-13-00010
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7TZ
UT WOS:000340805200006
PM 23756068
ER
PT J
AU Hill, OT
Bulathsinhala, L
Scofield, DE
Haley, TF
Bernasek, TL
AF Hill, Owen T.
Bulathsinhala, Lakmini
Scofield, Dennis E.
Haley, Timothy F.
Bernasek, Thomas L.
TI Risk Factors for Soft Tissue Knee Injuries in Active Duty US Army
Soldiers, 2000-2005
SO MILITARY MEDICINE
LA English
DT Article
ID ANTERIOR CRUCIATE LIGAMENT; OPERATION IRAQI FREEDOM;
PHYSICAL-ACTIVITIES; OSTEOARTHRITIS; DISABILITY; DISORDERS;
RECONSTRUCTION; HISTORY; REPAIR; JOINT
AB Background: There is a scarcity of analytic research on active duty Army (ADA) knee injuries (KI), such as soft tissue knee injuries (STKI), which are the predominant ADA KI pattern. Purpose: To quantify the independent adjusted association of significant ADA STKI risk factors, 2000-2005. Materials/Methods: Using the Total Army Injury and Health Outcomes Database, we (1) captured absolute STKI numbers and rates (N = 83,323) and (2) developed regression models to determine significant STKI risk factors. Models included STKI overall and subcategories: meniscus, patella, anterior/posterior cruciate ligament, and medial/lateral cruciate ligament. Results: Eight risk factors significantly increased STKI. They are: (1) prior KI (within 2 years) (odds ratio [OR] 9.83, 95% confidence interval [CI] 9.67-10.00); (2) increasing length of service (OR 1.83, 95% CI 1.76-1.90); (3) increasing age (OR 1.57, 95% CI 1.50-1.65); (4) prior deployment (OR 1.39, 95% CI 1.36-1.41); (5) prior ankle injury (OR 1.16, 95% CI 1.14-1.19); (6) Infantry occupation (OR 1.12, 95% CI 1.04-1.21); (7) marital status (OR 1.10, 95% CI 1.08-1.12); (8) and prior hip injury (OR 1.08, 95% CI 1.03-1.12). Major Conclusion: Soldiers with a prior KI have nearly a 10-fold increased relative risk of developing a subsequent STKI.
C1 [Hill, Owen T.; Bulathsinhala, Lakmini; Scofield, Dennis E.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA.
[Haley, Timothy F.] US Army Res Inst Environm Med, Off Med Support & Oversight, Natick, MA 01760 USA.
[Bernasek, Thomas L.] Florida Orthopaed Inst, Tampa, FL 33637 USA.
RP Hill, OT (reprint author), US Army Res Inst Environm Med, Mil Performance Div, 15 Kansas St,Bldg 42, Natick, MA 01760 USA.
RI SCOFIELD, DENNIS/F-3636-2015
FU Military Operational Medicine Research Program [8840]; U.S. Army
Research Institute of Environmental Medicine
FX This study was made possible by internal funding from the Military
Operational Medicine Research Program, Proposal No. 8840. This research
was supported in part by an appointment to the Postgraduate Research
Participation Program at the U.S. Army Research Institute of
Environmental Medicine administered by the Oak Ridge Institute for
Science and Education through an interagency agreement between the U.S.
Department of Energy and U.S. Army Medical Research and Materiel
Command.
NR 34
TC 8
Z9 8
U1 0
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JUN
PY 2013
VL 178
IS 6
BP 676
EP 682
DI 10.7205/MILMED-D-13-00049
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7TZ
UT WOS:000340805200014
PM 23756076
ER
PT J
AU Hall, NM
Jones, FJ
Ainsworth, CR
Fincher, RK
AF Hall, Noah M.
Jones, Frances J.
Ainsworth, Craig R.
Fincher, R. Keith
TI Methemoglobinemia in Patients Undergoing Esophagogastroduodenoscopy: A
Randomized Controlled Trial
SO MILITARY MEDICINE
LA English
DT Article
ID BENZOCAINE-INDUCED METHEMOGLOBINEMIA; OXIMETRY
AB Background: Methemoglobinemia is a potentially life-threatening complication of local anesthetic sprays employed in upper endoscopy. There is limited information available on the incidence of this complication, and no prospective trial has ever undertaken to evaluate subclinical levels of methemoglobinemia. Objective: To evaluate the incidence of subclinical methemoglobinemia in patients exposed to anesthetic spray. Methods: Subjects were randomized to a "spray" or "no-spray" group. Subjects in the "spray" group received a 1-second benzocaine spray before upper endoscopy. All subjects in both groups were monitored with a noninvasive co-oximetry device capable of detecting methemoglobin levels in real time. Results: 401 subjects were enrolled (209 in the study group, 192 in the control group); mean peak methemoglobin concentrations were 0.82% (CI 0.74-0.90%, SD 0.57%) and 0.80% (CI 0.73-0.86%, SD 0.46%) respectively. There was no statistically significant difference between the two groups (p = 0.69). Only 3 (1.4%) subjects in the study group and 2 (1%) subjects in the control group had a peak methemoglobin concentration >2%. Conclusions: In this randomized clinical trial, no significant elevation of methemoglobin concentration was observed in any subject. Final analysis failed to demonstrate any statistically significant difference between the two groups.
C1 [Hall, Noah M.; Fincher, R. Keith] DD Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA.
[Jones, Frances J.] San Antonio Mil Med Ctr, Dept Gastroenterol, Ft Sam Houston, TX 78234 USA.
[Ainsworth, Craig R.] Walter Reed Natl Mil Med Ctr, Crit Care Dept, Bethesda, MD 20814 USA.
RP Hall, NM (reprint author), DD Eisenhower Army Med Ctr, 300 East Hosp Rd, Ft Gordon, GA 30905 USA.
FU Massimo Corporation through the Geneva Foundation
FX The funding for this trial in the form of oximetry equipment and
academic conference travel expenses was provided by the Massimo
Corporation through a grant from the Geneva Foundation.
NR 13
TC 2
Z9 2
U1 0
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JUN
PY 2013
VL 178
IS 6
BP 701
EP 704
DI 10.7205/MILMED-D-13-00035
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7TZ
UT WOS:000340805200018
PM 23756080
ER
PT J
AU Forney, AJ
AF Forney, Andrew J.
TI Fighting Jim Crow in the County of Kings: The Congress of Racial
Equality in Brooklyn.
SO NEW YORK HISTORY
LA English
DT Book Review
C1 [Forney, Andrew J.] US Mil Acad, West Point, NY 10996 USA.
RP Forney, AJ (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU NEW YORK STATE HIST ASSOC
PI COOPERSTOWN
PA PO BOX 800, COOPERSTOWN, NY 13326-0800 USA
SN 0146-437X
EI 2328-8132
J9 NEW YORK HIST
JI N. Y. Hist.
PD SUM-FAL
PY 2013
VL 94
IS 3-4
BP 360
EP 362
PG 3
WC History
SC History
GA V36QF
UT WOS:000209225300022
ER
PT J
AU Nanduri, B
Suvarnapunya, AE
Venkatesan, M
Edelmann, MJ
AF Nanduri, Bindu
Suvarnapunya, Akamol E.
Venkatesan, Malabi
Edelmann, Mariola J.
TI Deubiquitinating Enzymes as Promising Drug Targets for Infectious
Diseases
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Deubiquitinating enzymes; drug discovery; ubiquitin; infectious
diseases; post-translational modifications
ID NF-KAPPA-B; UBIQUITIN-SPECIFIC PROTEASE; SMALL-MOLECULE INHIBITOR; I
INTERFERON-PRODUCTION; INNATE IMMUNE-RESPONSE; NEGATIVE FEEDBACK LOOP;
STIMULATED GENE 15; VIRUS TYPE-1 TAX; PLASMODIUM-FALCIPARUM;
NONSTRUCTURAL PROTEIN-2
AB Deubiquitinating enzymes (DUBs) remove ubiquitin and ubiquitin-like modifications from proteins and they have been known to contribute to processes relevant in microbial infection, such as immune responses pathways. Numerous viral and bacterial DUBs have been identified, and activities of several host DUBs are known to be modulated during the infection process, either by a pathogen or by a host. Recently there have been attempts to take advantage of this feature and design therapeutic inhibitors of DUBs that can be used to limit the spread of infection. This review is focused on exploring the potential of DUBs in the treatment of infectious diseases.
C1 [Nanduri, Bindu; Edelmann, Mariola J.] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Mississippi State, MS 39762 USA.
[Nanduri, Bindu; Edelmann, Mariola J.] Mississippi State Univ, Coll Vet Med, Dept Basic Sci, Mississippi State, MS 39762 USA.
[Suvarnapunya, Akamol E.; Venkatesan, Malabi] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA.
RP Edelmann, MJ (reprint author), Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Pace Seed Lab, Mailstop 9758,Rm 120,650 Stone Blvd, Mississippi State, MS 39762 USA.
EM mje100@mafes.msstate.edu
OI Edelmann, Mariola/0000-0003-0459-7716
FU MTA [013743-001]; MAFES Special Research Initiatives (Edelmann) Control
of Food-Borne Pathogens [160000-018100-027100-401120]; National Science
Foundation [Mississippi EPSCoR-0903787]; Mississippi INBRE; National
Center for Research Resources [5P20RR016476-11]; National Institute of
General Medical Sciences from the National Institutes of Health [8 P20
GM103476-11]
FX The work with WRAIR has been done using the MTA agreement (Award#
013743-001). This work was partially supported by the MAFES Special
Research Initiatives (Edelmann) Control of Food-Borne Pathogens
(160000-018100-027100-401120), The National Science Foundation
(Mississippi EPSCoR-0903787), and Mississippi INBRE funded by grants
from the National Center for Research Resources (5P20RR016476-11), and
the National Institute of General Medical Sciences (8 P20 GM103476-11)
from the National Institutes of Health.
NR 140
TC 9
Z9 10
U1 0
U2 19
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD JUN
PY 2013
VL 19
IS 18
BP 3234
EP 3247
PG 14
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 133RD
UT WOS:000318156100008
PM 23151130
ER
PT J
AU Scenna, R
DuBois, TG
Nieh, S
AF Scenna, Richard
DuBois, Terry G.
Nieh, Sen
TI Autothermal reforming of synthetic JP-8 derived from a coal syngas
stream
SO FUEL
LA English
DT Article
DE Autothermal fuel reforming; Coal liquefaction; JP-8 fuel; Fuel
reforming; Synthetic paraffinic kerosene fuel
ID CATALYTIC PARTIAL OXIDATION; FISCHER-TROPSCH FUEL; LIQUID FUELS; JET
FUEL; CARBON FORMATION; DIESEL-FUEL; HYDROCARBONS; GAS; EMISSIONS;
HYDROGEN
AB The performance characteristics of a coal based synthetic JP-8 fuel were evaluated on an autothermal reformer experimental test stand. The target application for the reformate was a solid oxide fuel cell power unit. The synthetic JP-8 fuel was derived through the Fischer-Tropsch process, resulting in a predominantly paraffin based fuel. The synthetic JP-8 fuel was reacted in an atmospheric pressure autothermal reformer with noble metal catalysts under conditions of steam-to-carbon ratio of 2.0, fuel equivalency energy flow of 3.33 kW thermal to 6.66 kW thermal, and variable oxygen-to-carbon ratios of 0.8-1.2. For all fuel equivalency flow rates investigated, fuel conversion of greater than 96% were achieved. The synthetic fuel produced high reforming efficiencies of up to 92.2%, with hydrogen concentrations up to 36.5%. The results show that coal derived JP-8 fuels can produce high reforming efficiencies, with high hydrogen concentrations while minimizing carbon formation in an ATR reactor. Published by Elsevier Ltd.
C1 [Scenna, Richard; DuBois, Terry G.] USA, Res Dev & Engn Command, Aberdeen Proving Ground, MD 21005 USA.
[Nieh, Sen] Catholic Univ Amer, Dept Mech Engn, Washington, DC 20064 USA.
RP DuBois, TG (reprint author), USA, Res Dev & Engn Command, 5100 Magazine Rd, Aberdeen Proving Ground, MD 21005 USA.
EM terry.g.dubois.civ@mail.mil; nieh@cua.edu
FU United States Army Research, Development, and Engineering Command;
Communication-Electronics Research, Development and Engineering Center
under an In-House Laboratory Independent Research project
FX The authors gratefully acknowledge support from the United States Army
Research, Development, and Engineering Command,
Communication-Electronics Research, Development and Engineering Center
under an In-House Laboratory Independent Research project.
NR 49
TC 7
Z9 7
U1 1
U2 33
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0016-2361
J9 FUEL
JI Fuel
PD JUN
PY 2013
VL 108
BP 731
EP 739
DI 10.1016/j.fuel.2013.02.022
PG 9
WC Energy & Fuels; Engineering, Chemical
SC Energy & Fuels; Engineering
GA 125TV
UT WOS:000317565100085
ER
PT J
AU David, NV
Gao, XL
Zheng, JQ
AF David, N. V.
Gao, X. -L.
Zheng, J. Q.
TI Creep of a Twaron (R)/Natural Rubber Composite
SO MECHANICS OF ADVANCED MATERIALS AND STRUCTURES
LA English
DT Article
DE ballistic fabrics; creep; compliance; retardation time; viscoelasticity;
rheological models; natural rubber; para-aramid fibers
ID ARAMID FIBERS; VISCOELASTIC PROPERTIES; STRESS RELAXATION; POLYMER
FIBERS; NATURAL-RUBBER; TENSILE CREEP; BEHAVIOR; DEFORMATION;
TEMPERATURE; EXTENSION
AB The creep behavior of a Twaron CT709 (R) fabric/natural rubber composite under a uniaxial constant stress is studied using three viscoelasticity models with different levels of complexity and a newly developed para-rheological model. The three viscoelasticity models employed are a one-term generalized Maxwell (GM n =1) model (consisting of one Maxwell element and an additional spring in parallel), a two-term generalized Maxwell (GM n =2) model (including two parallel Maxwell elements and an additional spring in parallel), and a four-parameter Burgers model. The values of the parameters involved in each model are extracted from the experimental data obtained in this study. The numerical results show that the initial creep response of the composite is predicted fairly well by the GM n =2 model, while the secondary creep is more accurately described by the GM n =1 model. An implicit solution, together with a retardation time spectrum, obtained using the para-rheological model is found to provide more accurate predictions of the composite creep response than the three viscoelasticity models in both the primary and secondary stages. The long-time response of the composite is also studied using the four models, with the para-rheological model providing the best predictions.
C1 [David, N. V.] Univ Teknol MARA, Fac Mech Engn, Shah Alam, Selangor, Malaysia.
[Gao, X. -L.] Univ Texas Dallas, Dept Mech Engn, Richardson, TX 75080 USA.
[Zheng, J. Q.] USA, Program Execut Off SOLDIER, Ft Belvoir, VA USA.
RP Gao, XL (reprint author), Univ Texas Dallas, Dept Mech Engn, 800 West Campbell Rd, Richardson, TX 75080 USA.
EM Xin-Lin.Gao@utdallas.edu
RI N.V., David/B-1987-2010
OI N.V., David/0000-0003-4128-5850
FU U.S. Army-Soldier Equipment Program
FX The work reported here is partially funded by the U.S. Army-Soldier
Equipment Program. This support is gratefully acknowledged.
NR 43
TC 0
Z9 0
U1 1
U2 36
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1537-6494
J9 MECH ADV MATER STRUC
JI Mech. Adv. Mater. Struct.
PD JUN 1
PY 2013
VL 20
IS 6
BP 464
EP 477
DI 10.1080/15376494.2012.676719
PG 14
WC Materials Science, Multidisciplinary; Mechanics; Materials Science,
Characterization & Testing; Materials Science, Composites
SC Materials Science; Mechanics
GA 121YU
UT WOS:000317282600006
ER
PT J
AU Kim, CS
Sohn, I
Nezafati, M
Ferguson, JB
Schultz, BF
Bajestani-Gohari, Z
Rohatgi, PK
Cho, K
AF Kim, Chang-Soo
Sohn, Il
Nezafati, Marjan
Ferguson, J. B.
Schultz, Benjamin F.
Bajestani-Gohari, Zahra
Rohatgi, Pradeep K.
Cho, Kyu
TI Prediction models for the yield strength of particle-reinforced unimodal
pure magnesium (Mg) metal matrix nanocomposites (MMNCs)
SO JOURNAL OF MATERIALS SCIENCE
LA English
DT Article
ID HALL-PETCH PARAMETERS; GRAIN-SIZE DEPENDENCE; MECHANICAL-PROPERTIES;
TENSILE PROPERTIES; SILICON-CARBIDE; ZN ALLOY; DEFORMATION MECHANISMS;
SIC PARTICLES; LENGTH-SCALE; ELEMENTAL MG
AB Particle-reinforced metal matrix nanocomposites (MMNCs) have been lauded for their potentially superior mechanical properties such as modulus, yield strength, and ultimate tensile strength. Though these materials have been synthesized using several modern solid- or liquid-phase processes, the relationships between material types, contents, processing conditions, and the resultant mechanical properties are not well understood. In this paper, we examine the yield strength of particle-reinforced MMNCs by considering individual strengthening mechanism candidates and yield strength prediction models. We first introduce several strengthening mechanisms that can account for increase in the yield strength in MMNC materials, and address the features of currently available yield strength superposition methods. We then apply these prediction models to the existing dataset of magnesium MMNCs. Through a series of quantitative analyses, it is demonstrated that grain refinement plays a significant role in determining the overall yield strength of most of the MMNCs developed to date. Also, it is found that the incorporation of the coefficient of thermal expansion mismatch and modulus mismatch strengthening mechanisms will considerably overestimate the experimental yield strength. Finally, it is shown that work-hardening during post-processing of MMNCs employed by many researchers is in part responsible for improvement to the yield strength of these materials.
C1 [Kim, Chang-Soo; Nezafati, Marjan; Ferguson, J. B.; Schultz, Benjamin F.; Bajestani-Gohari, Zahra; Rohatgi, Pradeep K.] Univ Wisconsin, Dept Mat Sci & Engn, Milwaukee, WI 53211 USA.
[Sohn, Il] Yonsei Univ, Dept Mat Sci & Engn, Seoul 120749, South Korea.
[Cho, Kyu] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Kim, CS (reprint author), Univ Wisconsin, Dept Mat Sci & Engn, Milwaukee, WI 53211 USA.
EM kimcs@uwm.edu
RI Schultz, Benjamin/H-8229-2014;
OI Schultz, Benjamin/0000-0002-0235-7674; Nezafati,
Marjan/0000-0002-6939-0460
FU Research Growth Initiative (RGI) Award from University of
Wisconsin-Milwaukee (UWM); U.S. Army Research Laboratory (US ARL)
[W911NF-08-2-0014]
FX This work is primarily supported by the Research Growth Initiative (RGI)
Award from University of Wisconsin-Milwaukee (UWM). Partial support from
the U.S. Army Research Laboratory (US ARL) under Cooperative Agreement
No. W911NF-08-2-0014 is also acknowledged. The views, opinions, and
conclusions made in this document are those of the authors and should
not be interpreted as representing the official policies, either
expressed or implied, of Army Research Laboratory or the U. S.
Government. The U. S. Government is authorized to reproduce and
distribute reprints for Government purposes notwithstanding any
copyright notation herein.
NR 71
TC 30
Z9 30
U1 1
U2 43
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0022-2461
J9 J MATER SCI
JI J. Mater. Sci.
PD JUN
PY 2013
VL 48
IS 12
BP 4191
EP 4204
DI 10.1007/s10853-013-7232-x
PG 14
WC Materials Science, Multidisciplinary
SC Materials Science
GA 116VN
UT WOS:000316911300005
ER
PT J
AU Zhang, SS
AF Zhang, Sheng S.
TI Liquid electrolyte lithium/sulfur battery: Fundamental chemistry,
problems, and solutions
SO JOURNAL OF POWER SOURCES
LA English
DT Review
DE Lithium/sulfur battery; Polysulfide; Redox shuttle; Electrolyte;
Carbon-sulfur composite; Li anode
ID COMPOSITE CATHODE MATERIALS; GLYCOL) DIMETHYL ETHER; HIGH-CAPACITY
DENSITY; LI-S BATTERY; SULFUR BATTERIES; ELECTROCHEMICAL PROPERTIES;
CARBON NANOTUBES; ENHANCED CYCLABILITY; GRAPHENE OXIDE; ION BATTERIES
AB Lithium/sulfur (Li/S) battery has a 3-5 fold higher theoretical energy density than state-of-art lithium-ion batteries, and research has been ongoing for more than three decades. However, the commercialization of Li/S battery still cannot be realized due to many problematic issues, including short cycle life, low cycling efficiency, poor safety and a high self-discharge rate. All these issues are related to the dissolution of lithium polysulfide (PS), the series of sulfur reduction intermediates, in liquid electrolyte and to resulting parasitic reactions with the lithium anode and electrolyte components. On the other hand, the dissolution of PS is essential for the performance of a Li/S cell. Without dissolution of PS, the Li/S cell cannot operate progressively due to the non-conductive nature of elemental sulfur and its reduction products. In this review article, we start with the fundamental chemistry of elemental sulfur in order to discuss the problems and solutions of liquid electrolyte Li/S battery. Published by Elsevier B.V.
C1 USA, Electrochem Branch, RDRL SED C, Sensors & Elect Devices Directorate,Res Lab, Adelphi, MD 20783 USA.
RP Zhang, SS (reprint author), USA, Electrochem Branch, RDRL SED C, Sensors & Elect Devices Directorate,Res Lab, Adelphi, MD 20783 USA.
EM shengshui.zhang.civ@mail.mil
RI Zhang, Sheng/A-4456-2012
OI Zhang, Sheng/0000-0003-4435-4110
NR 106
TC 417
Z9 431
U1 119
U2 1422
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-7753
J9 J POWER SOURCES
JI J. Power Sources
PD JUN 1
PY 2013
VL 231
BP 153
EP 162
DI 10.1016/j.jpowsour.2012.12.102
PG 10
WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials
Science, Multidisciplinary
SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science
GA 104ZZ
UT WOS:000316036700019
ER
PT J
AU Kalcioglu, ZI
Mrozek, RA
Mahmoodian, R
VanLandingham, MR
Lenhart, JL
Van Vliet, KJ
AF Kalcioglu, Z. Ilke
Mrozek, Randy A.
Mahmoodian, Roza
VanLandingham, Mark R.
Lenhart, Joseph L.
Van Vliet, Krystyn J.
TI Tunable mechanical behavior of synthetic organogels as biofidelic tissue
simulants
SO JOURNAL OF BIOMECHANICS
LA English
DT Article
DE Tissue simulants; Rheology; Impact indentation; PDMS; Soft tissues;
Energy dissipation
ID MODEL POLY(DIMETHYLSILOXANE) NETWORKS; STRAIN-ENERGY DENSITY; PENDANT
CHAINS; VISCOELASTIC PROPERTIES; HUMAN TORSO; IMPACT; GELS; MODULUS;
ENTANGLEMENT; DISSIPATION
AB Solvent-swollen polymer gels can be utilized as mechanical simulants of biological tissues to evaluate protective systems and assess injury mechanisms. However, a key challenge in this application of synthetic materials is mimicking the rate-dependent mechanical response of complex biological tissues. Here, we characterize the mechanical behavior of tissue simulant gel candidates comprising a chemically crosslinked polydimethylsiloxane (PDMS) network loaded with a non-reactive PDMS solvent, and compare this response with that of tissue from murine heart and liver under comparable loading conditions. We first survey the rheological properties of a library of tissue simulant candidates to investigate the effects of solvent loading percentage, reactive functional group stoichiometry, and solvent molecular weight. We then quantify the impact resistance, energy dissipation capacities, and energy dissipation rates via impact indentation for the tissue simulant candidates, as well as for the murine heart and liver. We demonstrate that by tuning these variables the silicone gels can be engineered to match the impact response of biological tissues. These experiments inform the design principles required for synthetic polymer gels that are optimized to predict the response of specific biological tissues to impact loading, providing insight for further tuning of this gel system to match the impact response of other "soft tissues". (C) 2013 Published by Elsevier Ltd.
C1 [Kalcioglu, Z. Ilke; Mahmoodian, Roza; Van Vliet, Krystyn J.] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA.
[Mrozek, Randy A.; VanLandingham, Mark R.; Lenhart, Joseph L.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Lenhart, JL (reprint author), USA, Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA.
EM joseph.lenhart.civ@mail.mil; krystyn@mit.edu
FU U.S. Army through the Institute for Soldier Nanotechnologies
[W911NF-07-D-0004]; U.S. Army Research Office
FX This research was supported in part by the U.S. Army through the
Institute for Soldier Nanotechnologies, under Contract W911NF-07-D-0004
with the U.S. Army Research Office. Certain commercial equipment and
materials are identified in this paper in order to specify adequately
the experimental procedure. In no case does such identification imply
recommendations by the Army Research Laboratory nor does it imply that
the material or equipment identified is necessarily the best available
for this purpose.
NR 43
TC 11
Z9 11
U1 2
U2 28
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0021-9290
J9 J BIOMECH
JI J. Biomech.
PD MAY 31
PY 2013
VL 46
IS 9
BP 1583
EP 1591
DI 10.1016/j.jbiomech.2013.03.011
PG 9
WC Biophysics; Engineering, Biomedical
SC Biophysics; Engineering
GA 170CQ
UT WOS:000320827700015
PM 23623681
ER
PT J
AU Pinzon-Arango, PA
Nagarajan, R
Camesano, TA
AF Pinzon-Arango, Paola A.
Nagarajan, Ramanathan
Camesano, Terri A.
TI Interactions of Antimicrobial Peptide Chrysophsin-3 with Bacillus
anthracis in Sporulated, Germinated, and Vegetative States
SO JOURNAL OF PHYSICAL CHEMISTRY B
LA English
DT Article
ID ATOMIC-FORCE MICROSCOPY; RED-SEA BREAM; SPORE GERMINATION; CEREUS; COAT;
DISRUPTION; ENDOSPORES; ELASTICITY; MECHANISM; CELLS
AB Bacillus anthracis spores contain on their surface multilayered protein coats that provide barrier properties, mechanical strength, and elasticity that aid in protecting the sporulated state and preventing germination, outgrowth, and transition into the virulent vegetative bacterial state. In this work, the antimicrobial peptide (AMP) chrysophsin-3 was tested against B. anthracis in each of the three distinct metabolic states (sporulated, germinated, and vegetative) for its bacteria-killing activity and its ability to modify the surface nanomechanical properties. Our results provide the first demonstration that chrysophsin-3 killed B. anthracis even in its sporulated state while more killing was observed for germinated and vegetative states. The elasticity of vegetative B. anthracis increased from 12 +/- 6 to 84 +/- 17 MPa after exposure to 0.22 mM chrysophsin-3. An increase in cellular spring constant was also observed for chrysophsin-3-treated vegetative B. anthracis. Atomic force microscopy images suggested that the changes in mechanical properties of vegetative B. anthracis after chrysophsin-3 treatment are due to loss of water content and cellular material from the cell, possibly caused by the disruption of the cell membrane by the AMP. In contrast, sporulated and germinated B. anthracis retained their innate mechanical properties. Our data indicate that chrysophsin-3 can penetrate the spore coat of B. anthracis spores and kill them without causing any significant mechanical changes on the spore surface. These results reveal a yet unrecognized role for chrysophsin-3 in the killing of B. anthracis spores without the need for complete germination or release of spore coats.
C1 [Pinzon-Arango, Paola A.; Camesano, Terri A.] Worcester Polytech Inst, Dept Chem Engn, Worcester, MA 01609 USA.
[Pinzon-Arango, Paola A.; Nagarajan, Ramanathan] USA, Natick Soldier Res Dev & Engn Ctr, Mol Sci & Engn Team, Natick, MA 01760 USA.
RP Camesano, TA (reprint author), WPI Life Sci & Bioengn Ctr Gateway Pk, Dept Chem Engn, 100 Inst Rd, Worcester, MA 01609 USA.
EM terric@wpi.edu
OI Nagarajan, Ramanathan/0000-0003-4758-2231
FU National Science Foundation [CBET 0827229, CBET 0922901]; Defense Threat
Reduction Agency [BA07PRO102]
FX This work was supported in part by the National Science Foundation (CBET
0827229 and CBET 0922901) and Defense Threat Reduction Agency Project
BA07PRO102.
NR 30
TC 4
Z9 4
U1 2
U2 13
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1520-6106
J9 J PHYS CHEM B
JI J. Phys. Chem. B
PD MAY 30
PY 2013
VL 117
IS 21
BP 6364
EP 6372
DI 10.1021/jp400489u
PG 9
WC Chemistry, Physical
SC Chemistry
GA 157LE
UT WOS:000319896800003
PM 23631815
ER
PT J
AU Macareo, L
Lwin, KM
Cheah, PY
Yuentrakul, P
Miller, RS
Nosten, F
AF Macareo, Louis
Lwin, Khin Maung
Cheah, Phaik Yeong
Yuentrakul, Prayoon
Miller, R. Scott
Nosten, Francois
TI Triangular test design to evaluate tinidazole in the prevention of
Plasmodium vivax relapse
SO MALARIA JOURNAL
LA English
DT Article
DE Malaria; Plasmodium vivax; Tinidazole; Relapse; Triangular test;
Sequential analysis
ID CANCER CLINICAL-TRIALS; HEMOLYTIC-ANEMIA; PRIMAQUINE; MALARIA; THAILAND;
CYNOMOLGI
AB Background: There are very few drugs that prevent the relapse of Plasmodium vivax malaria in man. Tinidazole is a 5-nitroimidazole approved in the USA for the treatment of indications including amoebiasis and giardiasis. In the non-human primate relapsing Plasmodium cynomolgi/macaque malaria model, tinidazole cured one of six macaques studied with an apparent mild delay to relapse in the other five of 14-28 days compared to 11-12 days in controls. One study has demonstrated activity against P. vivax in man. Presented here are the results of a pilot phase II, randomized, open-label study conducted along the Thai-Myanmar border designed to evaluate the efficacy of tinidazole to prevent relapse of P. vivax when administered with chloroquine.
Methods: This study utilized a modified triangular test sequential analysis which allows repeated statistical evaluation during the course of enrolment while maintaining a specified power and type 1 error and minimizing recruitment of subjects. Enrolment was to be halted when a pre-specified success/failure ratio was surpassed. The study was designed to have a 5% type 1 error and 90% power to show whether tinidazole would produce a relapse rate of less than 20% or greater than 45% through Day 63 of weekly follow-up after initiation of treatment and initial parasite clearance with 3 days of an oral weight based dosing of chloroquine and five days of 2 grams/day of tinidazole.
Results: All subjects cleared their parasitaemia by Day 3. Six of the first seven subjects treated with tinidazole relapsed prior to Day 63 (average Day 48.3 (range 42-56)). This exceeded the upper boundary of the triangular test and enrolment to receive tinidazole was halted. A concurrent cohort of five subjects definitively treated with standard doses of primaquine and chloroquine (historically 100% effective) showed no episodes of recurrent P. vivax parasitaemia during the 63-day protocol specified follow-up period.
Conclusions: Tinidazole is ineffective in preventing relapse of P. vivax at the dose used. The macaque relapsing model appeared to correctly predict outcome in humans. Use of the modified triangular test allowed minimal enrolment and limited unnecessary exposure to the study drug and reduced costs. This adds weight to the ethical and economic advantages of this study design to evaluate similarly situated drugs.
C1 [Macareo, Louis; Miller, R. Scott] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
[Lwin, Khin Maung; Nosten, Francois] Shoklo Malaria Res Unit, Mae Sot 63110, Thailand.
[Lwin, Khin Maung; Cheah, Phaik Yeong; Yuentrakul, Prayoon; Nosten, Francois] Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Bangkok 10400, Thailand.
[Cheah, Phaik Yeong; Nosten, Francois] Univ Oxford, CCVTM, Nuffield Dept Clin Med, Ctr Trop Med, Oxford OX3 7LJ, England.
RP Macareo, L (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM louis.macareo@us.army.mil
OI Nosten, Francois/0000-0002-7951-0745
FU Wellcome Trust [089275]
NR 18
TC 4
Z9 4
U1 0
U2 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD MAY 29
PY 2013
VL 12
AR 173
DI 10.1186/1475-2875-12-173
PG 6
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 156NU
UT WOS:000319830000001
PM 23718705
ER
PT J
AU Kalkstein, AJ
AF Kalkstein, Adam J.
TI Regional Similarities in Seasonal Mortality across the United States: An
Examination of 28 Metropolitan Statistical Areas
SO PLOS ONE
LA English
DT Article
ID INFLUENZA-VIRUS; HEAT WAVES; MYOCARDIAL-INFARCTION; US CITIES;
TEMPERATURE; TRANSMISSION; DEATHS; POPULATION; ADMISSIONS; HUMIDITY
AB Human mortality exhibits a strong seasonal pattern with deaths in winter far exceeding those in the summer. While the pattern itself is clear, there have been very few studies examining whether the magnitude or timing of seasonal mortality varies considerably across space. Thus, the goal of this study is to conduct a comprehensive geographic analysis of seasonal mortality across the United States and to uncover systematic regional differences in such mortality. Unique seasonal mortality curves were created for 28 metropolitan statistical areas across the United States, and the amplitude and timing of mortality peaks were determined. The findings here indicate that the seasonality of mortality exhibits strong spatial variation with the largest seasonal mortality amplitudes found in the southwestern United States and the smallest in the North, along with South Florida. In addition, there were strong intra-regional similarities that exist among the examined cities, implying that environmental factors are more important than social factors in determining seasonal mortality response. This work begins to fill a large gap within the scientific literature concerning the geographic variation and underlying causes of seasonal mortality across the United States.
C1 US Mil Acad, Dept Geog & Environm Engn, West Point, NY 10996 USA.
RP Kalkstein, AJ (reprint author), US Mil Acad, Dept Geog & Environm Engn, West Point, NY 10996 USA.
EM Adam.Kalkstein@usma.edu
FU National Research Council; Davies Fellowship Program
FX This research was not funded. At present, Adam J. Kalkstein is being
funded through the National Research Council's Davies Fellowship
(http://sites.nationalacademies.org/PGA/RAP/PGA_050493), but this work
was conducted prior to receiving the fellowship. The funders had no role
in study design, data collection and analysis, decision to publish, or
preparation of the manuscript.; I would like to thank Dr. Thomas
DeFelice and the U.S. Army Research Laboratory for their assistance with
this project, along with the Center for the Study of Civil-Military
Operations at the United States Military Academy and the Davies
Fellowship Program. I would also like to express my sincere gratitude to
my Ph.D. advisor, Dr. Robert Balling, Jr. at Arizona State University,
where this research commenced.
NR 40
TC 4
Z9 4
U1 1
U2 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 29
PY 2013
VL 8
IS 5
AR e63971
DI 10.1371/journal.pone.0063971
PG 12
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 155DJ
UT WOS:000319725500089
PM 23734179
ER
PT J
AU Tomaras, GD
Ferrari, G
Shen, XY
Alam, SM
Liao, HX
Pollara, J
Bonsignori, M
Moody, MA
Fong, YY
Chen, X
Poling, B
Nicholson, CO
Zhang, RJ
Lu, XZ
Parks, R
Kaewkungwal, J
Nitayaphan, S
Pitisuttithum, P
Rerks-Ngarm, S
Gilbert, PB
Kim, JH
Michael, NL
Montefiori, DC
Haynes, BF
AF Tomaras, Georgia D.
Ferrari, Guido
Shen, Xiaoying
Alam, S. Munir
Liao, Hua-Xin
Pollara, Justin
Bonsignori, Mattia
Moody, M. Anthony
Fong, Youyi
Chen, Xi
Poling, Brigid
Nicholson, Cindo O.
Zhang, Ruijun
Lu, Xiaozhi
Parks, Robert
Kaewkungwal, Jaranit
Nitayaphan, Sorachai
Pitisuttithum, Punnee
Rerks-Ngarm, Supachai
Gilbert, Peter B.
Kim, Jerome H.
Michael, Nelson L.
Montefiori, David C.
Haynes, Barton F.
TI Vaccine-induced plasma IgA specific for the C1 region of the HIV-1
envelope blocks binding and effector function of IgG
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
ID BROADLY NEUTRALIZING ANTIBODIES; MONOCLONAL-ANTIBODY; EFFICACY TRIAL;
FC-RECEPTORS; RESPONSES; MEMBRANE; EPITOPES; INFECTION; AFFINITY; GP120
AB Analysis of correlates of risk of infection in the RV144 HIV-1 vaccine efficacy trial demonstrated that plasma IgG against the HIV-1 envelope (Env) variable region 1 and 2 inversely correlated with risk, whereas HIV-1 Env-specific plasma IgA responses directly correlated with risk. In the secondary analysis, antibody-dependent cellular cytotoxicity (ADCC) was another inverse correlate of risk, but only in the presence of low plasma IgA Env-specific antibodies. Thus, we investigated the hypothesis that IgA could attenuate the protective effect of IgG responses through competition for the same Env binding sites. We report that Env-specific plasma IgA/IgG ratios are higher in infected than in uninfected vaccine recipients in RV144. Moreover, Env-specific IgA antibodies from RV144 vaccinees blocked the binding of ADCC-mediating mAb to HIV-1 Env glycoprotein 120 (gp120). An Env-specific monomeric IgA mAb isolated from an RV144 vaccinee also inhibited the ability of natural killer cells to kill HIV-1-infected CD4(+) T cells coated with RV144-induced IgG antibodies. We show that monomeric Env-specific IgA, as part of postvaccination polyclonal antibody response, may modulate vaccine-induced immunity by diminishing ADCC effector function.
C1 [Tomaras, Georgia D.; Ferrari, Guido; Shen, Xiaoying; Alam, S. Munir; Liao, Hua-Xin; Pollara, Justin; Bonsignori, Mattia; Moody, M. Anthony; Chen, Xi; Zhang, Ruijun; Lu, Xiaozhi; Parks, Robert; Montefiori, David C.; Haynes, Barton F.] Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC 27710 USA.
[Tomaras, Georgia D.; Ferrari, Guido; Pollara, Justin; Montefiori, David C.] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA.
[Tomaras, Georgia D.; Haynes, Barton F.] Duke Univ, Med Ctr, Dept Immunol, Durham, NC 27710 USA.
[Tomaras, Georgia D.; Poling, Brigid; Nicholson, Cindo O.] Duke Univ, Med Ctr, Dept Microbiol & Mol Genet, Durham, NC 27710 USA.
[Shen, Xiaoying; Alam, S. Munir; Liao, Hua-Xin; Bonsignori, Mattia; Zhang, Ruijun; Lu, Xiaozhi; Haynes, Barton F.] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA.
[Moody, M. Anthony] Duke Univ, Med Ctr, Dept Pediat, Durham, NC 27710 USA.
[Fong, Youyi; Gilbert, Peter B.] Statist Ctr HIV AIDS Res & Prevent, Seattle, WA 98109 USA.
[Kaewkungwal, Jaranit; Pitisuttithum, Punnee] Mahidol Univ, Bangkok 10400, Thailand.
[Nitayaphan, Sorachai; Kim, Jerome H.; Michael, Nelson L.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi 11000, Thailand.
[Kim, Jerome H.; Michael, Nelson L.] US Mil HIV Res Program, Silver Spring, MD 20910 USA.
RP Tomaras, GD (reprint author), Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC 27710 USA.
EM gdt@duke.edu; gflmp@duke.edu
RI Ferrari, Guido/A-6088-2015; Tomaras, Georgia/J-5041-2016;
OI Moody, Tony/0000-0002-3890-5855
FU Center for HIV/AIDS Vaccine Immunology (CHAVI)-Immunogen Discovery Grant
[U01 AI067854]; National Institutes of Health, National Institute of
Allergy and Infectious Diseases Division of Acquired Immunodeficiency
Syndrome (NIH/NIAID/DAIDS); NIH NIAID [AI07392]; Bill and Melinda Gates
Foundation [1033098, 1040758]; Collaboration for AIDS Vaccine
Discovery-Vaccine Immune Monitoring Consortium (CAVD-VIMC) Grant
[3830913]; CAVD-VIMC Grant [CTVIMC OPP1032325]; HIV-1 Vaccine Trials
Network [5U01 AI46725-05]; Duke University Center for AIDS Research [P30
AI64518]; US Army Medical Research and Material Command [Y1-AI-2642-12];
NIAID [Y1-AI-2642-12, W81XWH-07-2-0067]; Henry M. Jackson Foundation for
the Advancement of Military Medicine, Inc.; US Department of Defense
FX We are indebted to the volunteers and clinical staff who participated in
the RV144 vaccine trial. We thank Drs. Merlin Robb, Robert O'Connell,
Kelly A. Soderberg, and Charla Andrews for clinical trial and/or project
management, Dr. Nicole L. Yates and R. Glenn Overman for technical
expertise, and Dr. Sarzotti-Kelsoe for quality assurance oversight. This
work was supported by the Center for HIV/AIDS Vaccine Immunology
(CHAVI)-Immunogen Discovery Grant U01 AI067854; National Institutes of
Health, National Institute of Allergy and Infectious Diseases Division
of Acquired Immunodeficiency Syndrome (NIH/NIAID/DAIDS); NIH NIAID Grant
AI07392; Bill and Melinda Gates Foundation Grants 1033098 and 1040758;
Collaboration for AIDS Vaccine Discovery-Vaccine Immune Monitoring
Consortium (CAVD-VIMC) Grant 3830913, CAVD-VIMC Grant CTVIMC OPP1032325,
HIV-1 Vaccine Trials Network 5U01 AI46725-05; and the Duke University
Center for AIDS Research Grant P30 AI64518. Funding was also provided by
Interagency Agreement Y1-AI-2642-12 between the US Army Medical Research
and Material Command and the NIAID through cooperative agreement
W81XWH-07-2-0067 between the Henry M. Jackson Foundation for the
Advancement of Military Medicine, Inc., and the US Department of
Defense.
NR 32
TC 131
Z9 131
U1 1
U2 20
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAY 28
PY 2013
VL 110
IS 22
BP 9019
EP 9024
DI 10.1073/pnas.1301456110
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 165RC
UT WOS:000320500000067
PM 23661056
ER
PT J
AU Cerco, CF
Threadgill, T
Noel, MR
Hinz, S
AF Cerco, Carl F.
Threadgill, Tammy
Noel, Mark R.
Hinz, Scott
TI Modeling the pH in the tidal fresh Potomac River under conditions of
varying hydrology and loads
SO ECOLOGICAL MODELLING
LA English
DT Article
DE pH; Alkalinity; Carbonate cycle; Potomac River; Cyanobacteria
ID SEDIMENT NUTRIENT FLUXES; CHESAPEAKE BAY; WATER-QUALITY; ALGAL GROWTH;
ESTUARY; CARBON; EUTROPHICATION; ACIDIFICATION; CYANOBACTERIA; EMBAYMENT
AB The pH of the freshwater portion of the Potomac River estuary attains 9-10.5, driven by photosynthesis during cyanobacteria blooms. Processes which contribute to elevated pH are examined by adding a mass-balance model of the carbonate cycle to an existing eutrophication model. Four new variables are added to the model suite: alkalinity, total inorganic carbon, total calcium, and calcium carbonate. The pH is computed from these four quantities via equilibrium kinetics. The model is employed in a continuous simulation of the years 1994-2000. Emphasis in examination of model results is placed on the tidal fresh portion of the system where elevated pH is an environmental concern. Model sensitivity analysis indicates hydrology has the greatest influence on pH. During low-flow periods, residence time is lengthy allowing ample time for algal production to occur. The production stimulates net uptake of TIC, and results in enhanced pH. Published by Elsevier B.V.
C1 [Cerco, Carl F.; Threadgill, Tammy; Noel, Mark R.] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Hinz, Scott] Limnotech Inc, Austin, TX 78731 USA.
RP Cerco, CF (reprint author), USA, Environm Lab, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM carl.f.cerco@usace.army.mil; tammy.l.threadgill@usace.army.mil;
mark.r.noel@usace.army.mil; shinz@limno.com
FU US Environmental Protection Agency Chesapeake Bay Program
FX The authors thank Dominic DiToro for pointing out the influence of the
ALK/TIC ratio on pH. The pH-alkalinity algorithms employed here were
initially developed by Dominic DiToro and James Fitzpatrick. The
phytoplankton component of the model was parameterized by Victor Bierman
and Amanda Flynn. R. Christian Jones contributed observations collected
in Gunston Cove and adjacent waters. This study was sponsored by the US
Environmental Protection Agency Chesapeake Bay Program.
NR 48
TC 3
Z9 3
U1 0
U2 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-3800
J9 ECOL MODEL
JI Ecol. Model.
PD MAY 24
PY 2013
VL 257
BP 101
EP 112
DI 10.1016/j.ecolmodel.2013.02.011
PG 12
WC Ecology
SC Environmental Sciences & Ecology
GA 135XH
UT WOS:000318323500010
ER
PT J
AU Patel, G
Karver, CE
Behera, R
Guyett, PJ
Sullenberger, C
Edwards, P
Roncal, NE
Mensa-Wilmot, K
Pollastri, MP
AF Patel, Gautam
Karver, Caitlin E.
Behera, Ranjan
Guyett, Paul J.
Sullenberger, Catherine
Edwards, Peter
Roncal, Norma E.
Mensa-Wilmot, Kojo
Pollastri, Michael P.
TI Kinase Scaffold Repurposing for Neglected Disease Drug Discovery:
Discovery of an Efficacious, Lapatanib-Derived Lead Compound for
Trypanosomiasis
SO JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
ID HUMAN AFRICAN TRYPANOSOMIASIS; IN-VITRO; PHARMACOLOGICAL VALIDATION;
BRUCEI PHOSPHODIESTERASES; SLEEPING SICKNESS; PROTEIN-KINASES;
CELL-CYCLE; INHIBITORS; ENDOCYTOSIS; GROWTH
AB Human African trypanosomiasis (HAT) is a neglected tropical disease caused by the protozoan parasite Trypanosoma brucei. Because drugs in use against HAT are toxic and require intravenous dosing, new drugs are needed. Initiating lead discovery campaigns by using chemical scaffolds from drugs approved for other indications can speed up drug discovery for neglected diseases. We demonstrated recently that the 4-anilinoquinazolines lapatinib (GW572016, 1) and canertinib (CI-1033) kill T. brucei with low micromolar EC50 values. We now report promising activity of analogues of 1, which provided an excellent starting point for optimization of the chemotype. Our compound optimization that has led to synthesis of several potent 4-anilinoquinazolines, including NEU617, 23a, a highly potent, orally bioavailable inhibitor of trypanosome replication. At the cellular level, 23a blocks duplication of the kinetoplast and arrests cytokinesis, making it a new chemical tool for studying regulation of the trypanosome cell cycle.
C1 [Patel, Gautam; Karver, Caitlin E.; Edwards, Peter; Pollastri, Michael P.] Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA.
[Patel, Gautam; Karver, Caitlin E.; Edwards, Peter; Pollastri, Michael P.] Northeastern Univ, Ctr Drug Discovery, Boston, MA 02115 USA.
[Behera, Ranjan; Guyett, Paul J.; Sullenberger, Catherine; Mensa-Wilmot, Kojo] Univ Georgia, Dept Cellular Biol, Athens, GA 30602 USA.
[Roncal, Norma E.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
RP Pollastri, MP (reprint author), Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA.
EM mensawil@uga.edu; m.pollastri@neu.edu
OI Guyett, Paul/0000-0001-8538-1954; pollastri, Michael/0000-0001-9943-7197
FU National Institutes of Health [R01AI082577, R21AI076647]; National
Science Foundation [MCB-0843603]; Northeastern University
FX Funding from the National Institutes of Health (R01AI082577 to M.P., and
R21AI076647 to K.M.-W.), the National Science Foundation (MCB-0843603),
Northeastern University, and a gift of compounds (Table 1) from
GlaxoSmithKline, Inc.. is gratefully acknowledged. We appreciate helpful
discussions with Dr. Richard Sciotti at Walter Reed Army Institute of
Research and Dr. Franco Lombardo at Novartis.
NR 50
TC 27
Z9 27
U1 3
U2 16
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0022-2623
J9 J MED CHEM
JI J. Med. Chem.
PD MAY 23
PY 2013
VL 56
IS 10
BP 3820
EP 3832
DI 10.1021/jm400349k
PG 13
WC Chemistry, Medicinal
SC Pharmacology & Pharmacy
GA 154CW
UT WOS:000319650100005
PM 23597080
ER
PT J
AU Wang, GS
Hu, N
Yang, HH
Wang, LM
Su, H
Wang, CY
Clifford, R
Dawsey, EM
Li, JM
Ding, T
Han, XY
Giffen, C
Goldstein, AM
Taylor, PR
Lee, MP
AF Wang, Gangshi
Hu, Nan
Yang, Howard H.
Wang, Lemin
Su, Hua
Wang, Chaoyu
Clifford, Robert
Dawsey, Erica M.
Li, Jian-Min
Ding, Ti
Han, Xiao-You
Giffen, Carol
Goldstein, Alisa M.
Taylor, Philip R.
Lee, Maxwell P.
TI Comparison of Global Gene Expression of Gastric Cardia and Noncardia
Cancers from a High-Risk Population in China
SO PLOS ONE
LA English
DT Article
ID SQUAMOUS-CELL CARCINOMA; NUTRITION INTERVENTION TRIALS; DISEASE-SPECIFIC
MORTALITY; CLINICAL-SIGNIFICANCE; DISTINCTIVE PATTERNS; SOMATIC
MUTATIONS; FAMILY-HISTORY; ESOPHAGEAL; LINXIAN; SUPPLEMENTATION
AB Objective: To profile RNA expression in gastric cancer by anatomic subsites as an initial step in identifying molecular subtypes and providing targets for early detection and therapy.
Methods: We performed transcriptome analysis using the Affymetrix GeneChip U133A in gastric cardia adenocarcinomas (n = 62) and gastric noncardia adenocarcinomas (n = 72) and their matched normal tissues from patients in Shanxi Province, and validated selected dysregulated genes with additional RNA studies. Expression of dysregulated genes was also related to survival of cases.
Results: Principal Component Analysis showed that samples clustered by tumor vs. normal, anatomic location, and histopathologic features. Paired t-tests of tumor/normal tissues identified 511 genes whose expression was dysregulated (P<4.7E-07 and at least two-fold difference in magnitude) in cardia or noncardia gastric cancers, including nearly one-half (n = 239, 47%) dysregulated in both cardia and noncardia, one-fourth dysregulated in cardia only (n = 128, 25%), and about one-fourth in noncardia only (n = 144, 28%). Additional RNA studies confirmed profiling results. Expression was associated with case survival for 20 genes in cardia and 36 genes in noncardia gastric cancers.
Conclusions: The dysregulated genes identified here represent a comprehensive starting point for future efforts to understand etiologic heterogeneity, develop diagnostic biomarkers for early detection, and test molecularly-targeted therapies for gastric cancer.
C1 [Wang, Gangshi; Hu, Nan; Wang, Lemin; Su, Hua; Wang, Chaoyu; Dawsey, Erica M.; Goldstein, Alisa M.; Taylor, Philip R.] NCI, Genet Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
[Yang, Howard H.; Lee, Maxwell P.] NCI, Off Director, Ctr Canc Res, Bethesda, MD 20892 USA.
[Clifford, Robert] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD USA.
[Li, Jian-Min; Ding, Ti; Han, Xiao-You] Shanxi Canc Hosp, Taiyuan, Shanxi, Peoples R China.
[Giffen, Carol] Informat Management Serv Inc, Silver Spring, MD USA.
RP Taylor, PR (reprint author), NCI, Genet Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
EM ptaylor@mail.nih.gov; leemax@mail.nih.gov
FU National Institutes of Health; Center for Cancer Research; National
Cancer Institute, the Division of Cancer Epidemiology and Genetics
FX This research is funded by the Intramural Research Program of the
National Institutes of Health, the National Cancer Institute, the
Division of Cancer Epidemiology and Genetics, and the Center for Cancer
Research. The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
NR 49
TC 17
Z9 18
U1 1
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 22
PY 2013
VL 8
IS 5
AR UNSP e63826
DI 10.1371/journal.pone.0063826
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 163UP
UT WOS:000320362700068
PM 23717493
ER
PT J
AU Chaudhury, S
Abdulhameed, MDM
Singh, N
Tawa, GJ
D'haeseleer, PM
Zemla, AT
Navid, A
Zhou, CE
Franklin, MC
Cheung, J
Rudolph, MJ
Love, J
Graf, JF
Rozak, DA
Dankmeyer, JL
Amemiya, K
Daefler, S
Wallqvist, A
AF Chaudhury, Sidhartha
Abdulhameed, Mohamed Diwan M.
Singh, Narender
Tawa, Gregory J.
D'haeseleer, Patrik M.
Zemla, Adam T.
Navid, Ali
Zhou, Carol E.
Franklin, Matthew C.
Cheung, Jonah
Rudolph, Michael J.
Love, James
Graf, John F.
Rozak, David A.
Dankmeyer, Jennifer L.
Amemiya, Kei
Daefler, Simon
Wallqvist, Anders
TI Rapid Countermeasure Discovery against Francisella tularensis Based on a
Metabolic Network Reconstruction
SO PLOS ONE
LA English
DT Article
ID MYCOBACTERIUM-TUBERCULOSIS; ESCHERICHIA-COLI; DRUG TARGETS;
PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE; CHORISMATE SYNTHASE; ACCURATE
DOCKING; SYSTEMS BIOLOGY; IN-SILICO; INHIBITORS; DATABASE
AB In the future, we may be faced with the need to provide treatment for an emergent biological threat against which existing vaccines and drugs have limited efficacy or availability. To prepare for this eventuality, our objective was to use a metabolic network-based approach to rapidly identify potential drug targets and prospectively screen and validate novel small-molecule antimicrobials. Our target organism was the fully virulent Francisella tularensis subspecies tularensis Schu S4 strain, a highly infectious intracellular pathogen that is the causative agent of tularemia and is classified as a category A biological agent by the Centers for Disease Control and Prevention. We proceeded with a staggered computational and experimental workflow that used a strain-specific metabolic network model, homology modeling and X-ray crystallography of protein targets, and ligand- and structure-based drug design. Selected compounds were subsequently filtered based on physiological-based pharmacokinetic modeling, and we selected a final set of 40 compounds for experimental validation of antimicrobial activity. We began screening these compounds in whole bacterial cell-based assays in biosafety level 3 facilities in the 20th week of the study and completed the screens within 12 weeks. Six compounds showed significant growth inhibition of F. tularensis, and we determined their respective minimum inhibitory concentrations and mammalian cell cytotoxicities. The most promising compound had a low molecular weight, was non-toxic, and abolished bacterial growth at 13 mu M, with putative activity against pantetheine-phosphate adenylyltransferase, an enzyme involved in the biosynthesis of coenzyme A, encoded by gene coaD. The novel antimicrobial compounds identified in this study serve as starting points for lead optimization, animal testing, and drug development against tularemia. Our integrated in silico/in vitro approach had an overall 15% success rate in terms of active versus tested compounds over an elapsed time period of 32 weeks, from pathogen strain identification to selection and validation of novel antimicrobial compounds.
C1 [Chaudhury, Sidhartha; Abdulhameed, Mohamed Diwan M.; Singh, Narender; Tawa, Gregory J.; Wallqvist, Anders] USA, Dept Def Biotechnol, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr,Med Res & Mat Comma, Ft Detrick, MD USA.
[D'haeseleer, Patrik M.; Zemla, Adam T.; Navid, Ali; Zhou, Carol E.] Lawrence Livermore Natl Lab, Livermore, CA USA.
[Franklin, Matthew C.; Cheung, Jonah; Rudolph, Michael J.; Love, James] New York Struct Biol Ctr, New York, NY USA.
[Graf, John F.] GE Co, GE Global Res, Diagnost & Biomed Technol, Computat Biol & Biostat Lab, Niskayuna, NY USA.
[Rozak, David A.; Dankmeyer, Jennifer L.; Amemiya, Kei] USA, Bacteriol Div, Med Res Inst Infect Dis, Ft Detrick, MD USA.
[Daefler, Simon] Mt Sinai Sch Med, New York, NY USA.
RP Wallqvist, A (reprint author), USA, Dept Def Biotechnol, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr,Med Res & Mat Comma, Ft Detrick, MD USA.
EM awallqvist@bhsai.org
RI AbdulHameed, Mohamed Diwan M/O-3088-2015;
OI AbdulHameed, Mohamed Diwan M/0000-0003-1483-4084; wallqvist,
anders/0000-0002-9775-7469
FU Defense Threat Reduction Agency [TMTI0004.09.BH.T, HDTRA1-08-C-0052,
TMTI10049.09.RD.T, W911SR-11-C-0014]
FX This work was supported by the Defense Threat Reduction Agency through
projects TMTI0004.09.BH.T, HDTRA1-08-C-0052, TMTI10049.09.RD.T, and
W911SR-11-C-0014. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
NR 70
TC 2
Z9 2
U1 1
U2 16
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 21
PY 2013
VL 8
IS 5
AR e63369
DI 10.1371/journal.pone.0063369
PG 13
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 149OK
UT WOS:000319330200030
PM 23704901
ER
PT J
AU Berry, JS
Trappey, AF
Sears, AK
Vreeland, TJ
Clifton, GT
Hale, DF
Patil, R
Holmes, JP
Ponniah, S
Mittendorf, EA
Peoples, GE
Van Echo, DC
AF Berry, John S.
Trappey, Alfred F.
Sears, Alan K.
Vreeland, Timothy J.
Clifton, Guy T.
Hale, Diane F.
Patil, Ritesh
Holmes, Jarrod P.
Ponniah, Sathibalan
Mittendorf, Elizabeth Ann
Peoples, George Earl
Van Echo, David C.
TI Biomarker correlation to clinical response in phase I/II trials of the
adjuvant breast cancer vaccine neuvax (nelipepimut-S or E75)
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO)
CY MAY 31-JUN 04, 2013
CL Chicago, IL
SP Amer Soc Clin Oncol
C1 Brooke Army Med Ctr, San Antonio, TX USA.
Roswell Pk Canc Inst, Dept Med, Buffalo, NY 14263 USA.
Naval Med Ctr San Diego, San Diego, CA USA.
USUHS, US Mil Canc Inst, Canc Vaccine Dev Program, Bethesda, MD USA.
Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA.
Walter Reed Natl Mil Med Ctr, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD MAY 20
PY 2013
VL 31
IS 15
SU S
MA TPS3126
PG 1
WC Oncology
SC Oncology
GA AG4VY
UT WOS:000335419605420
ER
PT J
AU Patil, R
Clifton, GT
Litton, JK
Shumway, NM
Vreeland, TJ
Berry, JS
Trappey, AF
Ponniah, S
Peoples, GE
Mittendorf, EA
AF Patil, Ritesh
Clifton, Guy T.
Litton, Jennifer Keating
Shumway, Nathan M.
Vreeland, Timothy J.
Berry, John S.
Trappey, Alfred F.
Ponniah, Sathibalan
Peoples, George Earl
Mittendorf, Elizabeth Ann
TI Safety and efficacy of the HER2-derived GP2 peptide vaccine in
combination with trastuzumab for breast cancer patients in the adjuvant
setting.
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO)
CY MAY 31-JUN 04, 2013
CL Chicago, IL
SP Amer Soc Clin Oncol
C1 Roswell Pk Canc Inst, Dept Med, Buffalo, NY 14263 USA.
Blanchfield Army Community Hosp, Ft Campbell, KY USA.
Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
San Antonio Mil Med Ctr, Ft Sam Houston, TX USA.
Brooke Army Med Ctr, San Antonio, TX USA.
USUHS, Canc Vaccine Dev Program, US Mil Canc Inst, Bethesda, MD USA.
Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD MAY 20
PY 2013
VL 31
IS 15
SU S
MA 3096
PG 1
WC Oncology
SC Oncology
GA AG4VY
UT WOS:000335419601228
ER
PT J
AU Steele, S
Bilchik, A
Johnson, E
Nissan, A
Peoples, GE
Eberhardt, J
Kalina, P
Petersen, B
Bruecher, BLDM
Protic, M
Avital, I
Stojadinovic, A
AF Steele, Scott
Bilchik, Anton
Johnson, Eric
Nissan, Aviram
Peoples, George Earl
Eberhardt, John
Kalina, Philip
Petersen, Benjamin
Bruecher, Bjoern L. D. M.
Protic, Mladjan
Avital, Itzhak
Stojadinovic, Alexander
TI Time-dependent estimates of recurrence and survival in colon cancer:
clinical decision support system tool development for adjuvant therapy
and oncological outcome assessment.
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO)
CY MAY 31-JUN 04, 2013
CL Chicago, IL
SP Amer Soc Clin Oncol
C1 Madigan Army Med Ctr, Tacoma, WA USA.
John Wayne Canc Inst, Santa Monica, CA USA.
Hadassah Univ Hosp Mt Scopus, Jerusalem, Israel.
Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA.
DecisionQ Corp, Washington, DC USA.
Theodor Billroth Acad, Int Consortium Res Excellence, Munich, Germany.
US Mil Canc Inst, Washington, DC USA.
Bon Secours Canc Inst, Richmond, VA USA.
Walter Reed Natl Mil Med Ctr, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD MAY 20
PY 2013
VL 31
IS 15
SU S
MA e14500
PG 1
WC Oncology
SC Oncology
GA AG4VY
UT WOS:000335419603482
ER
PT J
AU Trappey, AF
Berry, JS
Vreeland, TJ
Hale, DF
Sears, AK
Ponniah, S
Perez, SA
Clifton, GT
Papamichail, M
Shumway, NM
Mittendorf, EA
Peoples, GE
AF Trappey, Alfred F.
Berry, John S.
Vreeland, Timothy J.
Hale, Diane F.
Sears, Alan K.
Ponniah, Sathibalan
Perez, Sonia A.
Clifton, Guy T.
Papamichail, Michael
Shumway, Nathan M.
Mittendorf, Elizabeth Ann
Peoples, George Earl
TI Risk factors for development of delayed urticarial reactions in the
phase II trial of HER2 peptide vaccines plus GM-CSF versus GM-CSF alone
in high-risk breast cancer patients to prevent recurrence.
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO)
CY MAY 31-JUN 04, 2013
CL Chicago, IL
SP Amer Soc Clin Oncol
C1 Brooke Army Med Ctr, San Antonio, TX USA.
USUHS, US Mil Canc Inst, Canc Vaccine Dev Program, Bethesda, MD USA.
St Savas Canc Hosp, Canc Immunol & Immunotherapy Ctr, Athens, Greece.
Canc Immunol & Immunotherapy Ctr, Athens, Greece.
San Antonio Mil Med Ctr, Ft Sam Houston, TX USA.
Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD MAY 20
PY 2013
VL 31
IS 15
SU S
MA 3097
PG 1
WC Oncology
SC Oncology
GA AG4VY
UT WOS:000335419601229
ER
PT J
AU Trappey, F
Berry, JS
Vreeland, TJ
Hale, DF
Sears, AK
Ponniah, S
Perez, SA
Clifton, GT
Papamichail, M
Peoples, GE
Mittendorf, EA
AF Trappey, Francois
Berry, John S.
Vreeland, Timothy J.
Hale, Diane F.
Sears, Alan K.
Ponniah, Sathibalan
Perez, Sonia A.
Clifton, Guy T.
Papamichail, Michael
Peoples, George Earl
Mittendorf, Elizabeth Ann
TI Randomized phase II clinical trial of the anti-HER2 (GP2) vaccine to
prevent recurrence in high-risk breast cancer patients: A planned
interim analysis.
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO)
CY MAY 31-JUN 04, 2013
CL Chicago, IL
SP Amer Soc Clin Oncol
C1 Brooke Army Med Ctr, San Antonio, TX USA.
USUHS, US Mil Canc Inst, Canc Vaccine Dev Program, Bethesda, MD USA.
St Savas Canc Hosp, Athens, Greece.
Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA.
Canc Immunol & Immunotherapy Ctr, Athens, Greece.
Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD MAY 20
PY 2013
VL 31
IS 15
SU S
MA 3005
PG 1
WC Oncology
SC Oncology
GA AG4VY
UT WOS:000335419601138
ER
PT J
AU Bogle, X
Vazquez, R
Greenbaum, S
Cresce, AV
Xu, K
AF Bogle, Xavier
Vazquez, Rafael
Greenbaum, Steven
Cresce, Arthur von Wald
Xu, Kang
TI Understanding Li+-Solvent Interaction in Nonaqueous Carbonate
Electrolytes with O-17 NMR
SO JOURNAL OF PHYSICAL CHEMISTRY LETTERS
LA English
DT Article
ID GRAPHITE/ELECTROLYTE INTERFACE; SOLVATION SHEATH; LITHIUM-ION;
BATTERIES; GRAPHITE; SYSTEMS; CELLS
AB To understand how Li+ interacts with individual carbonate molecules in nonaqueous electrolytes, we conducted natural abundance O-17 NMR measurements on electrolyte solutions of 1 M LiPF6 in a series of binary solvent mixtures of ethylene carbonate (EC) and dimethyl carbonate (DMC). It was observed that the largest changes in O-17 chemical shift occurred at the carbonyl oxygens of EC, firmly establishing that Li+ strongly prefers EC over DMC in typical nonaqueous electrolytes, while mainly coordinating with carbonyl rather than ethereal oxygens. Further quantitative analysis of the displacements in O-17 chemical shifts renders a detailed Li+-solvation structure in these electrolyte solutions, revealing that maximum six EC molecules can coexist in the Li+-solvation sheath, while DMC association with Li+ is more "noncommittal" but simultaneously prevalent. This discovery, while aligning well with previous fragmental knowledge about Li+-solvation, reveals for the first time a complete picture of Li+ solvation structure in nonaqueous electrolytes.
C1 [Bogle, Xavier; Vazquez, Rafael; Greenbaum, Steven] CUNY Hunter Coll, Dept Phys & Astron, New York, NY 10065 USA.
[Vazquez, Rafael; Greenbaum, Steven] CUNY, Grad Ctr, New York, NY 10065 USA.
[Vazquez, Rafael; Greenbaum, Steven] CUNY, Grad Ctr, New York, NY 10016 USA.
[Cresce, Arthur von Wald; Xu, Kang] USA, Electrochem Branch, Res Lab, Adelphi, MD 20783 USA.
RP Greenbaum, S (reprint author), CUNY Hunter Coll, Dept Phys & Astron, New York, NY 10065 USA.
EM steve.greenbaum@hunter.cuny.edu; conrad.k.xu.civ@mail.mil
RI Cresce, Arthur/K-3958-2013
OI Cresce, Arthur/0000-0002-3894-6083
FU Army Research Office [W911NF-12-2-0059]; National Institutes of Health
RCMI infrastructure grant [RR 003037]
FX This work was supported by Army Research Office under contract number
W911NF-12-2-0059. The Hunter College NMR facility is supported by a
National Institutes of Health RCMI infrastructure grant (RR 003037). We
thank Dr. Matthew Devany of the NMR facility for technical assistance.
NR 21
TC 47
Z9 49
U1 6
U2 60
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1948-7185
J9 J PHYS CHEM LETT
JI J. Phys. Chem. Lett.
PD MAY 16
PY 2013
VL 4
IS 10
BP 1664
EP 1668
DI 10.1021/jz400661k
PG 5
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary; Physics, Atomic, Molecular & Chemical
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA 183DI
UT WOS:000321793800015
PM 26282976
ER
PT J
AU Krishnani, KK
Srinives, S
Mohapatra, BC
Boddu, VM
Hao, JM
Meng, X
Mulchandani, A
AF Krishnani, K. K.
Srinives, Sira
Mohapatra, B. C.
Boddu, V. M.
Hao, Jumin
Meng, X.
Mulchandani, Ashok
TI Hexavalent chromium removal mechanism using conducting polymers
SO JOURNAL OF HAZARDOUS MATERIALS
LA English
DT Article
DE Conducting polymers; Cr(VI) remediation; Mechanism; Chemical reduction
ID HEAVY-METALS; PALLADIUM NANOPARTICLES; REDUCTION; CR(VI); POLYANILINE;
POLYPYRROLE; DEGRADATION; ANILINE; WASTE; WATER
AB We report detoxification of Cr(VI) into Cr(III) using electrochemically synthesized polyaniline (PANI), polypyrrole (PPY), PANI nanowires (PANI-NW) and palladium-decorated PANI (PANI-Pd) thin films. Percent Cr(VI) reduction was found to be decreased with an increase in pH from 1.8 to 6.8 and with initial Cr(VI) concentration ranging from 2.5 to 10 mg/L. Efficacy of PANI increased at higher temp of 37 degrees C as compared to 30 degrees C. PANI-Pd was found to be most effective for all three initial Cr(VI) concentrations at pH 1.8. However, efficacy of PANI-Pd was significantly reduced at higher pHs of 5 and 6.8. Efficacy of PANI and PANI-NW was found to nearly the same. However, there was a significant reduction in effectiveness of PANI-NW at 10 mg/L of Cr(VI) at all the three pHs studied, which could be attributed to degradation of PANI-NW by higher initial Cr(VI) concentration. PPY and PANI-NW were found to be highly sensitive with respect to pH and Cr(VI) initial concentration. Chromium speciation on PANI film was carried out by total chromium analysis and XPS, which revealed Cr(III) formation and its subsequent adsorption on the polymer. PANI-Pd and PANI are recommended for future sensor applications for chromium detection at low pH. (c) 2013 Elsevier B.V. All rights reserved.
C1 [Krishnani, K. K.; Srinives, Sira; Mohapatra, B. C.; Mulchandani, Ashok] Univ Calif Riverside, Dept Chem & Environm Engn, Riverside, CA 92521 USA.
[Krishnani, K. K.] Natl Inst Abiot Stress Management, Pune 413115, Maharashtra, India.
[Srinives, Sira] Mahidol Univ, Dept Chem Engn, Nakhon Pathom 73170, Thailand.
[Mohapatra, B. C.] Cent Inst Freshwater Aquaculture, Bhubaneswar, Orissa, India.
[Boddu, V. M.] USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA.
[Hao, Jumin; Meng, X.] Stevens Inst Technol, Ctr Environm Syst, Hoboken, NJ 07030 USA.
RP Mulchandani, A (reprint author), Univ Calif Riverside, Dept Chem & Environm Engn, Riverside, CA 92521 USA.
EM adani@engr.ucr.edu
RI Mulchandani, Ashok/B-9692-2016
OI Mulchandani, Ashok/0000-0002-2831-4154
FU HRD-NAIP Programme of ICAR, New Delhi; Thai Government Scholarship,
Ministry of Science and Technology, Thailand
FX Dr. K.K. Krishnani and Dr B.C. Mohapatra acknowledge the financial
support from HRD-NAIP Programme of ICAR, New Delhi. Sira Srinives
acknowledges the Thai Government Scholarship, Ministry of Science and
Technology, Thailand.
NR 31
TC 30
Z9 30
U1 2
U2 104
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-3894
J9 J HAZARD MATER
JI J. Hazard. Mater.
PD MAY 15
PY 2013
VL 252
BP 99
EP 106
DI 10.1016/j.jhazmat.2013.01.079
PG 8
WC Engineering, Environmental; Engineering, Civil; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 162TL
UT WOS:000320288800013
PM 23507365
ER
PT J
AU Adams, SM
Bornemann, PH
AF Adams, Stephen M.
Bornemann, Paul H.
TI Ulcerative Colitis
SO AMERICAN FAMILY PHYSICIAN
LA English
DT Article
ID INFLAMMATORY-BOWEL-DISEASE; OF-THE-LITERATURE; DOUBLE-BLIND; MAINTAINING
REMISSION; THERAPY; METAANALYSIS; PROCTITIS; EFFICACY; PREVALENCE;
MESALAZINE
AB Ulcerative colitis is a chronic inflammatory disease of the colon. The etiology is unknown. Risk factors include a history of recent infection with Salmonella or Campylobacter, living in Western industrialized nations and at higher latitudes, and a family history of the disease. The incidence peaks in early adulthood, but patients can develop the disorder from early childhood through adulthood. Ulcerative colitis often presents with abdominal pain, diarrhea, and hematochezia. It is important to exclude infectious etiologies. Anemia and an elevated erythrocyte sedimentation rate or C-reactive protein level may suggest inflammatory bowel disease, but the absence of laboratory abnormalities does not rule out ulcerative colitis. The diagnosis is suspected clinically and confirmed through endoscopic biopsy. First-line treatment is therapy with 5-aminosalicylic acid. Corticosteroids may be added if 5-aminosalicylic acid therapy is ineffective. Infliximab can be added to induce and sustain remission. Patients with severe or nonresponsive ulcerative colitis should be hospitalized, and intravenous corticosteroids should be given. If medical management has been ineffective, surgical intervention is indicated for severe disease. Patients with ulcerative colitis have an increased risk of colon cancer and should have periodic colonoscopy beginning eight to 10 years after diagnosis. Copyright (C) 2013 American Academy of Family Physicians.
C1 [Adams, Stephen M.] Univ Tennessee, Coll Med, Chattanooga, TN 37403 USA.
[Bornemann, Paul H.] Tripler Army Med Ctr, Family Med Residency Program, Honolulu, HI 96859 USA.
[Bornemann, Paul H.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
RP Adams, SM (reprint author), Univ Tennessee, Coll Med, 1100 E 3rd St,Ste 101, Chattanooga, TN 37403 USA.
EM stephen.adams@erlanger.org
NR 40
TC 12
Z9 15
U1 1
U2 3
PU AMER ACAD FAMILY PHYSICIANS
PI KANSAS CITY
PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA
SN 0002-838X
J9 AM FAM PHYSICIAN
JI Am. Fam. Physician
PD MAY 15
PY 2013
VL 87
IS 10
BP 699
EP 705
PG 7
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA 150FA
UT WOS:000319374400004
PM 23939448
ER
PT J
AU Zarling, S
Berenzon, D
Dalai, S
Liepinsh, D
Steers, N
Krzych, U
AF Zarling, Stasya
Berenzon, Dmitriy
Dalai, Sarat
Liepinsh, Dmitry
Steers, Nick
Krzych, Urszula
TI The Survival of Memory CD8 T Cells That Is Mediated by IL-15 Correlates
with Sustained Protection Against Malaria
SO JOURNAL OF IMMUNOLOGY
LA English
DT Article
ID PLASMODIUM-FALCIPARUM SPOROZOITES; INFLUENZA-VIRUS INFECTION;
CIRCUMSPOROZOITE PROTEIN; ANTIGEN PRESENTATION; BERGHEI SPOROZOITES;
IMMUNE-RESPONSES; DENDRITIC CELLS; STAGE MALARIA; LIVER STAGES;
HOMEOSTATIC PROLIFERATION
AB Ag-specific memory T cell responses elicited by infections or vaccinations are inextricably linked to long-lasting protective immunity. Studies of protective immunity among residents of malaria endemic areas indicate that memory responses to Plasmodium Ags are not adequately developed or maintained, as people who survive episodes of childhood malaria are still vulnerable to either persistent or intermittent malaria infections. In contrast, multiple exposures to radiation-attenuated Plasmodium berghei sporozoites (Pb gamma-spz) induce long-lasting protective immunity to experimental sporozoite challenge. We previously demonstrated that sterile protection induced by Pb gamma-spz is MHC class I-dependent and CD8 T cells are the key effectors. IFN-gamma(+) CD8 T cells that arise in Pb gamma-spz-immunized B6 mice are found predominantly in the liver and are sensitive to levels of liver-stage Ag depot and they express CD44(hi)CD62L(lo) markers indicative of effector/effector memory phenotype. The developmentally related central memory CD8 T (T-CM) cells express elevated levels of CD122 (IL-15R beta), which suggests that CD8 T-CM cells depend on IL-15 for maintenance. Using IL-15-deficient mice, we demonstrate in this study that although protective immunity is inducible in these mice, protection is short-lived, mainly owing to the inability of CD8 T-CM cells to survive in the IL-15-deficient milieu. We present a hypothesis consistent with a model whereby intrahepatic CD8 T-CM cells, being maintained by IL-15-mediated survival and basal proliferation, are conscripted into the CD8 effector/effector memory T cell pool during subsequent infections.
C1 [Zarling, Stasya; Berenzon, Dmitriy; Dalai, Sarat; Liepinsh, Dmitry; Steers, Nick; Krzych, Urszula] Walter Reed Army Inst Res, Dept Cellular Immunol, Malaria Vaccine Branch, Silver Spring, MD 20910 USA.
RP Krzych, U (reprint author), Walter Reed Army Inst Res, Dept Cellular Immunol, Malaria Vaccine Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM ukrzych@gmail.com
FU National Institutes of Health [AI 46438]; U.S. Army Materiel Command
FX The work was supported in part by National Institutes of Health Grant AI
46438 (to U.K.) and by the U.S. Army Materiel Command. S.Z. is a
National Research Council Research Associate.
NR 73
TC 19
Z9 20
U1 0
U2 4
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
J9 J IMMUNOL
JI J. Immunol.
PD MAY 15
PY 2013
VL 190
IS 10
BP 5128
EP 5141
DI 10.4049/jimmunol.1203396
PG 14
WC Immunology
SC Immunology
GA 138YB
UT WOS:000318546700024
PM 23589611
ER
PT J
AU Amorim, RG
Zhong, XL
Mukhopadhyay, S
Pandey, R
Rocha, AR
Karna, SP
AF Amorim, Rodrigo G.
Zhong, Xiaoliang
Mukhopadhyay, Saikat
Pandey, Ravindra
Rocha, Alexandre R.
Karna, Shashi P.
TI Strain- and electric field-induced band gap modulation in nitride
nanomembranes
SO JOURNAL OF PHYSICS-CONDENSED MATTER
LA English
DT Article
ID BORON-NITRIDE; SILICON NANOMEMBRANES; ELASTIC-CONSTANTS; GRAPHENE;
FABRICATION; PRESSURE; DEVICES; ALN
AB The hexagonal nanomembranes of the group III-nitrides are a subject of interest due to their novel technological applications. In this paper, we investigate the strain- and electric field-induced modulation of their band gaps in the framework of density functional theory. For AlN, the field-dependent modulation of the bandgap is found to be significant whereas the strain-induced semiconductor-metal transition is predicted for GaN. A relatively flat conduction band in AlN and GaN nanomembranes leads to an enhancement of their electronic mobility compared to that of their bulk counterparts.
C1 [Amorim, Rodrigo G.; Zhong, Xiaoliang; Mukhopadhyay, Saikat; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA.
[Rocha, Alexandre R.] Univ Fed ABC, Ctr Ciencias Nat & Humanas, Santo Andre, SP, Brazil.
[Rocha, Alexandre R.] Univ Estadual Paulista UNESP, Inst Fis Teor, Sao Paulo, Brazil.
[Karna, Shashi P.] USA, Ballist Res Lab, Weap & Mat Res Directorate, ATTN RDL WM, Aberdeen Proving Ground, MD 21005 USA.
RP Amorim, RG (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA.
EM pandey@mtu.edu
RI Mukhopadhyay, Saikat/B-4402-2011; Rocha, Alexandre/F-9504-2010; Amorim,
Rodrigo /I-6173-2012; Zhong, Xiaoliang/B-2220-2012; Amorim,
Rodrigo/N-4139-2016
OI Rocha, Alexandre/0000-0001-8874-6947; Amorim,
Rodrigo/0000-0001-9611-8772
FU CNPQ; FAPESP; Army Research Office [W911NF-09-1-0221]
FX We acknowledge support from Brazilian Agencies CNPQ and FAPESP and
computational resources CENAPAD/SP and NACAD/UFRJ. The work at Michigan
Technological University was performed under support by the Army
Research Office through Contract Number W911NF-09-1-0221.
NR 41
TC 11
Z9 11
U1 1
U2 38
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0953-8984
J9 J PHYS-CONDENS MAT
JI J. Phys.-Condes. Matter
PD MAY 15
PY 2013
VL 25
IS 19
AR 195801
DI 10.1088/0953-8984/25/19/195801
PG 7
WC Physics, Condensed Matter
SC Physics
GA 132LP
UT WOS:000318070100022
PM 23604312
ER
PT J
AU Sviatenko, LK
Gorb, L
Hill, FC
Leszczynski, J
AF Sviatenko, Liudmyla K.
Gorb, Leonid
Hill, Frances C.
Leszczynski, Jerzy
TI Theoretical study of ionization and one-electron oxidation potentials of
N-heterocyclic compounds
SO JOURNAL OF COMPUTATIONAL CHEMISTRY
LA English
DT Article
DE redox potential; DFT calculations; N-heterocyclic compounds;
electrochemistry; solvation
ID SOLVATION FREE-ENERGIES; DENSITY FUNCTIONALS; THERMOCHEMICAL KINETICS;
REDOX POTENTIALS; ACETONITRILE; COMPUTATION; DERIVATIVES; PREDICTION;
ACCURATE; DESIGN
AB A number of density functionals was utilized to predict gas-phase adiabatic ionization potentials (IPs) for nitrogen-rich heterocyclic compounds. Various solvation models were applied to the calculation of difference in free energies of solvation of oxidized and reduced forms of heterocyclic compounds in acetonitrile (AN) for correct reproduction of their standard oxidation potentials. We developed generally applicable protocols that could successfully predict the gas-phase adiabatic ionization potentials of nitrogen-rich heterocyclic compounds and their standard oxidation potentials in AN. This approach is supported by a MPW1K/6-31+G(d) level of theory which uses SMD(UA0) approximation for estimation of solvation energy of neutral molecules and PCM(UA0) model for ionized ones. The mean absolute derivation (MAD) and root mean square error (RMSE) of the current theoretical models for IP are equal to 0.22 V and 0.26, respectively, and for oxidation potentials MAD = 0.13 V and RMSE = 0.17. (c) 2013 Wiley Periodicals, Inc.
C1 [Sviatenko, Liudmyla K.; Leszczynski, Jerzy] Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Nanotox Ctr, Jackson, MS 39217 USA.
[Sviatenko, Liudmyla K.] Kirovohrad Volodymyr Vynnychenko State Pedag Univ, Dept Nat & Geog Sci, UA-25006 Kirovohrad, Ukraine.
[Gorb, Leonid] Badger Tech Serv Inc, Huntsville, AL 35805 USA.
[Hill, Frances C.] USA, Environm Lab, ERDC, Vicksburg, MS 39180 USA.
RP Sviatenko, LK (reprint author), Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Nanotox Ctr, Jackson, MS 39217 USA.
EM jerzy@icnanotox.org
FU National Science Foundation [NSF/CREST HRD 0833178]; EPSCoR
[362492-190200-01\NSFEPS-090378]
FX Contract/grant sponsor: National Science Foundation; Contract/grant
number: NSF/CREST HRD 0833178; Contract/grant sponsor: EPSCoR Award;
Contract/grant number: 362492-190200-01\NSFEPS-090378.
NR 41
TC 11
Z9 11
U1 2
U2 45
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0192-8651
J9 J COMPUT CHEM
JI J. Comput. Chem.
PD MAY 15
PY 2013
VL 34
IS 13
BP 1094
EP 1100
DI 10.1002/jcc.23228
PG 7
WC Chemistry, Multidisciplinary
SC Chemistry
GA 123ZO
UT WOS:000317432400002
PM 23335274
ER
PT J
AU Rangasamy, E
Wolfenstine, J
Allen, J
Sakamoto, J
AF Rangasamy, Ezhiylmurugan
Wolfenstine, Jeff
Allen, Jan
Sakamoto, Jeff
TI The effect of 24c-site (A) cation substitution on the tetragonal-cubic
phase transition in Li(7-x)La(3-x)A(x)Zr(2)O(12) garnet-based ceramic
electrolyte
SO JOURNAL OF POWER SOURCES
LA English
DT Article
DE Solid-electrolyte; Garnet; Ce; Cubic; Li vacancies; Hot-pressing
ID LITHIUM-ION BATTERIES; YTTRIUM-IRON-GARNET; SOLID-ELECTROLYTE;
LI7LA3ZR2O12; CONDUCTIVITY; STATE; AL; TRANSPORT; GA
AB The garnet-type ceramic electrolyte of nominal composition Li7La3Zr2O12 can exist in the tetragonal and cubic form. This article investigates the tetragonal to cubic phase transition based on super-valent cation substitution on the 24c site typically occupied by La (3+) in the garnet structure. Ce (4+) was selected as the super-valent cation represented as x in Li7-xLa3-xCexZr2O12. The doping study showed that cubic LLZO was stabilized for Ce >= 0.2. These data agree with most literature reports suggesting that the creation of Li vacancies, while maintaining oxygen stoichiometry, is necessary to stabilize cubic LLZO. Moreover, this work suggests a critical Li vacancy concentration (0.12-0.4 mol per mole of Li7La3Zr2O12) is necessary to stabilize cubic LLZO. While the addition of Ce stabilized cubic LLZO, the total ionic conductivity (0.014 mS cm(-1)) was considerably lower compared to Al and Ta doped LLZO (0.4-0.9 mS cm(-1), respectively). The lower conductivity is likely due to CeO2 precipitation at grain boundaries. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Rangasamy, Ezhiylmurugan; Allen, Jan; Sakamoto, Jeff] Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA.
[Wolfenstine, Jeff] USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA.
RP Sakamoto, J (reprint author), Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA.
EM jsakamot@msu.edu
RI Rangasamy, Ezhiylmurugan/K-8340-2013
FU U.S. Army Research Office (ARO); U.S. Army Research Laboratory (ARL)
FX Authors EL and JS would like to acknowledge the support of the U.S. Army
Research Office (ARO). JW and JA would like to acknowledge support of
the U.S. Army Research Laboratory (ARL).
NR 30
TC 28
Z9 28
U1 17
U2 265
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-7753
J9 J POWER SOURCES
JI J. Power Sources
PD MAY 15
PY 2013
VL 230
BP 261
EP 266
DI 10.1016/j.jpowsour.2012.12.076
PG 6
WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials
Science, Multidisciplinary
SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science
GA 099FF
UT WOS:000315606000037
ER
PT J
AU Kaplan, D
Swaminathan, V
Recine, G
Balu, R
Karna, S
AF Kaplan, D.
Swaminathan, V.
Recine, G.
Balu, R.
Karna, S.
TI Bandgap tuning of mono- and bilayer graphene doped with group IV
elements
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
ID HEXAGONAL BORON-NITRIDE; EPITAXIAL GRAPHENE; TUNABLE BANDGAP;
ELECTRIC-FIELD; GAP
AB We report density functional theory band structure calculations of graphene doped with group IV elements. A bandgap as high as 2.13 eV is calculated for a single layer of graphene doped with Si while Ge and Sn doping reduce this bandgap for equal doping concentrations. Bilayers of doped graphene are also studied and it is found that the bandgap of these materials is less than that of the single layer counterparts. Finally, a transverse electric field is applied to the doped bilayers and it is found that the bandgap is inversely proportional to the electric field strength in contrast to what has been observed in the case of pristine bilayers. Carrier effective masses were calculated and in general the effective masses of electrons and holes are found to be similar. (C) 2013 AIP Publishing LLC.
C1 [Kaplan, D.; Swaminathan, V.] USA, RDECOM ARDEC, Acoust & Networked Sensors Div, Picatinny Arsenal, NJ 07806 USA.
[Recine, G.] NYU, Polytech Inst, Dept Appl Phys, Brooklyn, NY 11201 USA.
[Recine, G.] Fordham Univ, Dept Phys & Engn Phys, Bronx, NY 10458 USA.
[Balu, R.; Karna, S.] USA, RDECOM ARL, Weap & Mat Res Directorate, Aberdeen, MD 21005 USA.
RP Kaplan, D (reprint author), USA, RDECOM ARDEC, Acoust & Networked Sensors Div, Picatinny Arsenal, NJ 07806 USA.
EM daniel.b.kaplan.civ@mail.mil
NR 33
TC 10
Z9 10
U1 2
U2 58
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0021-8979
EI 1089-7550
J9 J APPL PHYS
JI J. Appl. Phys.
PD MAY 14
PY 2013
VL 113
IS 18
AR 183701
DI 10.1063/1.4804060
PG 5
WC Physics, Applied
SC Physics
GA 149BX
UT WOS:000319294100034
ER
PT J
AU Gut, IM
Beske, PH
Hubbard, KS
Lyman, ME
Hamilton, TA
McNutt, PM
AF Gut, Ian M.
Beske, Phillip H.
Hubbard, Kyle S.
Lyman, Megan E.
Hamilton, Tracey A.
McNutt, Patrick M.
TI Novel Application of Stem Cell-Derived Neurons to Evaluate the Time- and
Dose-Dependent Progression of Excitotoxic Injury
SO PLOS ONE
LA English
DT Article
ID HIPPOCAMPAL-NEURONS; IN-VITRO; MONOSODIUM GLUTAMATE;
MOLECULAR-MECHANISMS; BRAIN LESIONS; DEATH; APOPTOSIS; NECROSIS;
CULTURES; DEPOLARIZATION
AB Glutamate receptor (GluR)-mediated neurotoxicity is implicated in a variety of disorders ranging from ischemia to neural degeneration. Under conditions of elevated glutamate, the excessive activation of GluRs causes internalization of pathologic levels of Ca2+, culminating in bioenergetic failure, organelle degradation, and cell death. Efforts to characterize cellular and molecular aspects of excitotoxicity and conduct therapeutic screening for pharmacologic inhibitors of excitogenic progression have been hindered by limitations associated with primary neuron culture. To address this, we evaluated glutamate-induced neurotoxicity in highly enriched glutamatergic neurons (ESNs) derived from murine embryonic stem cells. As of 18 days in vitro (DIV 18), ESNs were synaptically coupled, exhibited spontaneous network activity with neurotypic mEPSCs and expressed NMDARs and AMPARs with physiological current: voltage behaviors. Addition of 0.78-200 mu M glutamate evoked reproducible time-and dose-dependent metabolic failure in 6 h, with a calculated EC50 value of 0.44 mu M at 24 h. Using a combination of cell viability assays and electrophysiology, we determined that glutamate-induced toxicity was specifically mediated by NMDARs and could be inhibited by addition of NMDAR antagonists, increased extracellular Mg2+ or substitution of Ba2+ for Ca2+. Glutamate treatment evoked neurite fragmentation and focal swelling by both immunocytochemistry and scanning electron microscopy. Presentation of morphological markers of cell death was dose-dependent, with 0.78-200 mu M glutamate resulting in apoptosis and 3000 mu M glutamate generating a mixture of necrosis and apoptosis. Addition of neuroprotective small molecules reduced glutamate-induced neurotoxicity in a dose-dependent fashion. These data indicate that ESNs replicate many of the excitogenic mechanisms observed in primary neuron culture, offering a moderate-throughput model of excitotoxicity that combines the verisimilitude of primary neurons with the flexibility and scalability of cultured cells. ESNs therefore offer a physiologically relevant platform that exhibits characteristic NMDAR responses, and appears suitable to evaluate molecular mechanisms of glutamate-induced excitotoxicity and screen for candidate therapeutics.
C1 [Gut, Ian M.; Beske, Phillip H.; Hubbard, Kyle S.; Lyman, Megan E.; Hamilton, Tracey A.; McNutt, Patrick M.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
RP McNutt, PM (reprint author), USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
EM patrick.mcnutt@us.army.mil
OI McNutt, Patrick/0000-0002-5703-4565
FU National Institutes of Health National Institute of Allergy and
Infectious Diseases [AOD12058-0001-0000]; Defense Threat Reduction
Agency - Joint Science and Technology Office, Medical ST Division
[CBM.THRTOX.01.10.RC.021]
FX This work was funded by the National Institutes of Health National
Institute of Allergy and Infectious Diseases (IAA number
AOD12058-0001-0000) and the Defense Threat Reduction Agency - Joint
Science and Technology Office, Medical S&T Division (grant number
CBM.THRTOX.01.10.RC.021). The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
NR 42
TC 9
Z9 9
U1 1
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 14
PY 2013
VL 8
IS 5
AR e64423
DI 10.1371/journal.pone.0064423
PG 13
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 146RE
UT WOS:000319107400125
PM 23691214
ER
PT J
AU Amani, M
Chin, ML
Birdwell, AG
O'Regan, TP
Najmaei, S
Liu, Z
Ajayan, PM
Lou, J
Dubey, M
AF Amani, Matin
Chin, Matthew L.
Birdwell, A. Glen
O'Regan, Terrance P.
Najmaei, Sina
Liu, Zheng
Ajayan, Pulickel M.
Lou, Jun
Dubey, Madan
TI Electrical performance of monolayer MoS2 field-effect transistors
prepared by chemical vapor deposition
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID ATOMIC LAYERS; MOBILITY
AB Molybdenum disulfide (MoS2) field effect transistors (FET) were fabricated on atomically smooth large-area single layers grown by chemical vapor deposition. The layer qualities and physical properties were characterized using high-resolution Raman and photoluminescence spectroscopy, scanning electron microscopy, and atomic force microscopy. Electronic performance of the FET devices was measured using field effect mobility measurements as a function of temperature. The back-gated devices had mobilities of 6.0 cm(2)/V s at 300 K without a high-k dielectric overcoat and increased to 16.1 cm(2)/V s with a high-k dielectric overcoat. In addition the devices show on/off ratios ranging from 10(5) to 10(9). (C) 2013 AIP Publishing LLC.
C1 [Amani, Matin; Chin, Matthew L.; Birdwell, A. Glen; O'Regan, Terrance P.; Dubey, Madan] USA, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20723 USA.
[Amani, Matin] Oregon State Univ, Dept Elect Engn, Corvallis, OR 97331 USA.
[Najmaei, Sina; Liu, Zheng; Ajayan, Pulickel M.; Lou, Jun] Rice Univ, Dept Mech Engn & Mat Sci, Houston, TX 77005 USA.
RP Dubey, M (reprint author), USA, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20723 USA.
EM madan.dubey.civ@mail.mil
RI najmaei, sina/H-8536-2013; Liu, Zheng/C-1813-2014
OI Liu, Zheng/0000-0002-8825-7198
FU Army Research Lab (ARL) Director's Strategic Initiative (DSI) program;
ARO MURI
FX The authors acknowledge the support of the Army Research Lab (ARL)
Director's Strategic Initiative (DSI) program on interfaces in stacked
2D atomic layered materials. The authors would also like to thank Dr.
Pani Varanasi, ARO for his in-depth technical discussion on 2D atomic
layer R&D. P.M.A., J.L., S.N, and Z.L. also acknowledge funding support
from the ARO MURI program on 2D materials. The views and conclusions
contained in this document are those of the authors and should not be
interpreted as representing the official policies, either expressed or
implied, of the ARL or the U.S. Government. The U.S. Government is
authorized to reproduce or distribute reprints for Government purposes
notwithstanding any copyright notation herein.
NR 22
TC 81
Z9 81
U1 9
U2 179
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0003-6951
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD MAY 13
PY 2013
VL 102
IS 19
AR 193107
DI 10.1063/1.4804546
PG 4
WC Physics, Applied
SC Physics
GA 164WB
UT WOS:000320440800086
ER
PT J
AU Cochrane, CJ
Lenahan, PM
Lelis, AJ
AF Cochrane, C. J.
Lenahan, P. M.
Lelis, A. J.
TI The effect of nitric oxide anneals on silicon vacancies at and very near
the interface of 4H SiC metal oxide semiconducting field effect
transistors using electrically detected magnetic resonance
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID 4H-SIC MOSFETS
AB We use three electrically detected magnetic resonance (EDMR) approaches to explore nitric oxide (NO) annealing in 4H SiC metal-oxide-semiconductor field-effect transistors (MOSFETs). One approach is sensitive to defects at the interface and those extending into the SiC. Two of these approaches are particularly sensitive to SiC/SiO2 interface defects. They show that NO anneals decrease the EDMR response. Since this and earlier studies indicate the ubiquitous presence of silicon vacancy centers in SiC MOSFETs, our results provide strong circumstantial evidence that these defects play an important role in limiting device performance and that NO anneals are effective in reducing their populations. (C) 2013 AIP Publishing LLC.
C1 [Cochrane, C. J.; Lenahan, P. M.] Penn State Univ, Dept Engn Sci & Mech, University Pk, PA 16802 USA.
[Lelis, A. J.] USA, Res Lab, Adelphi, MD 20783 USA.
RP Cochrane, CJ (reprint author), Penn State Univ, Dept Engn Sci & Mech, 227 Hammond Bldg, University Pk, PA 16802 USA.
FU US Army Research Laboratory; General Electric under the U.S. Department
of Commerce [NIST60NANB10D109]
FX The authors would like to thank Daniel Habersat from the US Army
Research Lab and Thomas Aichinger from The Pennsylvania State University
(now with Infineon Technologies) for their insight. The work has been
primarily supported by the US Army Research Laboratory, with additional
support from General Electric under the U.S. Department of Commerce
under Award No. NIST60NANB10D109.
NR 16
TC 10
Z9 10
U1 3
U2 37
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0003-6951
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD MAY 13
PY 2013
VL 102
IS 19
AR 193507
DI 10.1063/1.4805355
PG 4
WC Physics, Applied
SC Physics
GA 164WB
UT WOS:000320440800104
ER
PT J
AU Eyase, FL
Akala, HM
Ingasia, L
Cheruiyot, A
Omondi, A
Okudo, C
Juma, D
Yeda, R
Andagalu, B
Wanja, E
Kamau, E
Schnabel, D
Bulimo, W
Waters, NC
Walsh, DS
Johnson, JD
AF Eyase, Fredrick L.
Akala, Hoseah M.
Ingasia, Luiser
Cheruiyot, Agnes
Omondi, Angela
Okudo, Charles
Juma, Dennis
Yeda, Redemptah
Andagalu, Ben
Wanja, Elizabeth
Kamau, Edwin
Schnabel, David
Bulimo, Wallace
Waters, Norman C.
Walsh, Douglas S.
Johnson, Jacob D.
TI The Role of Pfmdr1 and Pfcrt in Changing Chloroquine, Amodiaquine,
Mefloquine and Lumefantrine Susceptibility in Western-Kenya P.
falciparum Samples during 2008-2011
SO PLOS ONE
LA English
DT Article
ID RESISTANCE TRANSPORTER GENE; TIME QUANTITATIVE PCR;
PLASMODIUM-FALCIPARUM; ARTEMETHER-LUMEFANTRINE; IN-VIVO;
SULFADOXINE-PYRIMETHAMINE; MOLECULAR ANALYSIS; MALARIA; ARTEMISININ;
ARTESUNATE
AB Single Nucleotide Polymorphisms (SNPs) in the Pfmdr1, and Pfcrt, genes of Plasmodium falciparum may confer resistance to a number of anti-malaria drugs. Pfmdr1 86Y and haplotypes at Pfcrt 72-76 have been linked to chloroquine (CQ) as well as amodiaquine (AQ) resistance. mefloquine (MQ) and lumefantrine (LU) sensitivities are linked to Pfmdr1 86Y. Additionally, Pfcrt K76 allele carrying parasites have shown tolerance to LU. We investigated the association between Pfmdr1 86/Pfcrt 7276 and P. falciparum resistance to CQ, AQ, MQ and LU using field samples collected during 2008-2011 from malaria endemic sites in western Kenya. Genomic DNA from these samples was genotyped to examine SNPs and haplotypes in Pfmdr1 and Pfcrt respectively. Additionally, immediate ex vivo and in vitro drug sensitivity profiles were assessed using the malaria SYBR Green I fluorescence-based assay. We observed a rapid but steady percent increase in wild-type parasites with regard to both Pfmdr1 and Pfcrt between 2008 and 2011 (p<0.0001). Equally, a significant reciprocate decrease in AQ and CQ median IC50 values occurred (p<0.0001) during the same period. Thus, the data in this study point to a significantly rapid change in parasite response to AQ and CQ in the study period. This may be due to releasing of drug pressure on the parasite from reduced use of AQ in the face of increased Artemisinin (ART) Combination Therapy (ACT) administration following the intervention of the Global Fund in 2008. LU has been shown to select for 76K genotypes, thus the observed increase in 76K genotypes coupled with significant cross resistance between LU and MQ, may herald emergence of tolerance against both drugs in future.
C1 [Eyase, Fredrick L.; Akala, Hoseah M.; Ingasia, Luiser; Cheruiyot, Agnes; Omondi, Angela; Okudo, Charles; Juma, Dennis; Yeda, Redemptah; Andagalu, Ben; Wanja, Elizabeth; Kamau, Edwin; Bulimo, Wallace; Johnson, Jacob D.] USAMRU K, Dept Emerging Infect Dis Global Emerging Infect S, Nairobi, Kenya.
[Waters, Norman C.] US Mil Acad, New York, NY USA.
[Walsh, Douglas S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Schnabel, David] Walter Reed Army Inst Res, Silver Spring, MD USA.
RP Eyase, FL (reprint author), USAMRU K, Dept Emerging Infect Dis Global Emerging Infect S, Nairobi, Kenya.
EM fredrickeyase@yahoo.com
RI Valle, Ruben/A-7512-2013; Bulimo, Wallace/B-1982-2014
OI Bulimo, Wallace/0000-0001-8475-0586
FU Armed Forces Health Surveillance Center (AFHSC-GEIS)
FX This work was funded by the Armed Forces Health Surveillance Center
(AFHSC-GEIS). The funders had no role in study design, data collection
and analysis decision to publish, or preparation of the manuscript.
NR 45
TC 22
Z9 23
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 13
PY 2013
VL 8
IS 5
AR e64299
DI 10.1371/journal.pone.0064299
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 145RZ
UT WOS:000319036100061
PM 23675533
ER
PT J
AU Ochieng, C
Lutomiah, J
Makio, A
Koka, H
Chepkorir, E
Yalwala, S
Mutisya, J
Musila, L
Khamadi, S
Richardson, J
Bast, J
Schnabel, D
Wurapa, E
Sang, R
AF Ochieng, Caroline
Lutomiah, Joel
Makio, Albina
Koka, Hellen
Chepkorir, Edith
Yalwala, Santos
Mutisya, James
Musila, Lillian
Khamadi, Samoel
Richardson, Jason
Bast, Joshua
Schnabel, David
Wurapa, Eyako
Sang, Rosemary
TI Mosquito-borne arbovirus surveillance at selected sites in diverse
ecological zones of Kenya; 2007-2012
SO VIROLOGY JOURNAL
LA English
DT Article
DE Arbovirus; Surveillance; Mosquitoes
ID VALLEY FEVER VIRUS; WEST-NILE-VIRUS; POLYMERASE CHAIN-REACTION;
USUTU-VIRUS; RT-PCR; CHIKUNGUNYA; DISEASES; AUSTRIA; AFRICA
AB Background: Increased frequency of arbovirus outbreaks in East Africa necessitated the determination of distribution of risk by entomologic arbovirus surveillance. A systematic vector surveillance programme spanning 5 years and covering 11 sites representing seven of the eight provinces in Kenya and located in diverse ecological zones was carried out.
Methods: Mosquitoes were sampled bi-annually during the wet seasons and screened for arboviruses. Mosquitoes were identified to species, pooled by species, collection date and site and screened for arboviruses by isolation in cell culture and/or RT-PCR screening and sequencing.
Results: Over 450,000 mosquitoes in 15,890 pools were screened with 83 viruses being detected/isolated that include members of the alphavirus, flavivirus and orthobunyavirus genera many of which are known to be of significant public health importance in the East African region. These include West Nile, Ndumu, Sindbis, Bunyamwera, Pongola and Usutu viruses detected from diverse sites. Ngari virus, which was associated with hemorrhagic fever in northern Kenya in 1997/98 was isolated from a pool of Anopheles funestus sampled from Tana-delta and from Aedes mcintoshi from Garissa. Insect only flaviviruses previously undescribed in Kenya were also isolated in the coastal site of Rabai. A flavivirus most closely related to the Chaoyang virus, a new virus recently identified in China and two isolates closely related to Quang Binh virus previously unreported in Kenya were also detected.
Conclusion: Active transmission of arboviruses of public health significance continues in various parts of the country with possible undetermined human impact. Arbovirus activity was highest in the pastoralist dominated semi-arid to arid zones sites of the country where 49% of the viruses were isolated suggesting a role of animals as amplifiers and indicating the need for improved arbovirus disease diagnosis among pastoral communities.
C1 [Ochieng, Caroline; Lutomiah, Joel; Makio, Albina; Koka, Hellen; Yalwala, Santos; Mutisya, James; Musila, Lillian; Khamadi, Samoel; Bast, Joshua; Wurapa, Eyako; Sang, Rosemary] US Army Med Res Unit, Div Emerging Infect Dis, Nairobi, Kenya.
[Lutomiah, Joel; Khamadi, Samoel; Sang, Rosemary] Kenya Govt Med Res Ctr, Ctr Virus Res, Nairobi, Kenya.
[Chepkorir, Edith] Int Ctr Insect Physiol & Ecol, Nairobi, Kenya.
[Richardson, Jason; Schnabel, David] Walter Reed Army Inst Res, Silver Spring, MD USA.
RP Ochieng, C (reprint author), US Army Med Res Unit, Div Emerging Infect Dis, POB 606, Nairobi, Kenya.
EM caroline.ochieng@usamru-k.org
RI Valle, Ruben/A-7512-2013
FU Global Emerging Infections surveillance and response System (GEIS) of
the Armed Forces Health Surveillance Centre (AFHSC) under the United
States department of defense (DOD)
FX We acknowledge the technical contribution of Dunstone Betti, John
Gachoya, Daniel Ngonga, David Oulo, Francis Mulwa and Reuben Lugalia,
This work was funded by the Global Emerging Infections surveillance and
response System (GEIS) of the Armed Forces Health Surveillance Centre
(AFHSC) under the United States department of defense (DOD) and
supported by the Director, KEMRI.
NR 38
TC 14
Z9 14
U1 6
U2 24
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1743-422X
J9 VIROL J
JI Virol. J.
PD MAY 10
PY 2013
VL 10
AR 140
DI 10.1186/1743-422X-10-140
PG 10
WC Virology
SC Virology
GA 155WE
UT WOS:000319778300001
PM 23663381
ER
PT J
AU Seibert, M
Nieh, S
AF Seibert, Michael
Nieh, Sen
TI Simulation of dual firing of hydrogen-rich reformate and JP-8 surrogate
in a swirling combustor
SO INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
LA English
DT Article
DE Hydrogen; Fuel reforming; External combustion; Jet fuel; Dual firing
ID NOX REDUCTION; PERFORMANCE; ENGINE
AB Flame control, particularly at very lean conditions, is a critical requirement for external combustion power sources such as thermoelectric and thermophotovoltaic generators. The availability of in-situ produced hydrogen from JP-8 fuel reforming presents a potential supply of hydrogen at the application site, such as the battlefield, without adding a second fuel to the logistics system. This research investigates the use of small amounts of hydrogen co-fired with JP-8 for improved energy efficiency, operational flexibility and environmental protection. Numerical simulations were conducted in a 6 kW (thermal) swirling flow combustor under different conditions. The simulations use hydrogen and a single hydrocarbon surrogate for JP-8 with a 4-step reaction mechanism. It also examined the effect of using hydrogen-rich reformate containing hydrogen, carbon monoxide and other gases dual-fired with JP-8. Results showed that at lean conditions, dual firing of hydrogen or reformate with JP-8 provided improved fuel conversion, better flame stability and higher fuel burnout. Dual firing hydrogen-rich reformate and JP-8 led to increased burner capacity, reduced system size and weight requirements. However, dual firing with hydrogen provided little benefit to JP-8 combustion under stoichiometric or fuel rich conditions because they were limited by mixing rather than chemical kinetics. These results indicate that dual firing of hydrogen with JP-8 is a promising method for improving lean flame stability and burner control. This has the potential to enable small scale power applications with specific temperature requirements such as thermoelectric and thermophotovoltaic generators. Copyright (C) 2013, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.
C1 [Seibert, Michael] USA, Command Power & Integrat Directorate, RDECOM, CERDEC, Aberdeen Proving Ground, MD 21005 USA.
[Nieh, Sen] Catholic Univ Amer, Dept Mech Engn, Washington, DC 20064 USA.
RP Seibert, M (reprint author), USA, Command Power & Integrat Directorate, RDECOM, CERDEC, 5100 Magazine Rd, Aberdeen Proving Ground, MD 21005 USA.
EM michael.l.seibert.civ@mail.mil
OI Seibert, Michael/0000-0001-5902-7935
FU US Army Communications-Electronics Research Development and Engineering
Center
FX The authors gratefully acknowledge the US Army
Communications-Electronics Research Development and Engineering Center's
support in the form of an In-House Laboratory Independent Research
project that funded much of this work.
NR 10
TC 4
Z9 4
U1 1
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0360-3199
J9 INT J HYDROGEN ENERG
JI Int. J. Hydrog. Energy
PD MAY 10
PY 2013
VL 38
IS 14
BP 5911
EP 5917
DI 10.1016/j.ijhydene.2013.02.072
PG 7
WC Chemistry, Physical; Electrochemistry; Energy & Fuels
SC Chemistry; Electrochemistry; Energy & Fuels
GA 148GM
UT WOS:000319232500044
ER
PT J
AU Cuddy, MF
Poda, AR
Brantley, LN
AF Cuddy, Michael F.
Poda, Aimee R.
Brantley, Lauren N.
TI Determination of Isoelectric Points and the Role of pH for Common Quartz
Crystal Microbalance Sensors
SO ACS APPLIED MATERIALS & INTERFACES
LA English
DT Article
DE isoelectric point; IEP; quartz crystal microbalance; QCM; sensor; mucin
ID CONTACT-ANGLE TITRATIONS; PORCINE GASTRIC MUCIN; FORCE MEASUREMENTS;
DOUBLE-LAYER; SURFACE; OXIDE; ADSORPTION; AGGREGATION; TRANSITION; FILMS
AB Isoelectric points (IEPs) were determined by the method of contact angle titration for five common quartz crystal microbalance (QCM) sensors. The isoelectric points range from mildly basic in the case of Al2O3 sensors (IEP = 8.7) to moderately acidic for Au (5.2) and SiO2 (3.9), to acidic for Ag (3.2) and Ti (2.9). In general, the values reported here are indicative of inherent surface oxides. A demonstration of the effect of the surface isoelectric point on the packing efficiency of thin mucin films is provided for gold and silica QCM sensors. It is determined that mucin layers on both substrates achieve a maximum and equal layer density of similar to 3500 kg/m(3) at the corresponding IEP of either QCM sensor. This implies that mucin film packing is dependent upon short-range electrostatic interactions at the sensor surface.
C1 [Cuddy, Michael F.; Poda, Aimee R.; Brantley, Lauren N.] USA, Environm Lab, Corps Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Cuddy, MF (reprint author), USA, Environm Lab, Corps Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM Michael.Cuddy@usace.army.mil
RI Poda, Aimee/K-1905-2012
NR 29
TC 12
Z9 12
U1 3
U2 47
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1944-8244
J9 ACS APPL MATER INTER
JI ACS Appl. Mater. Interfaces
PD MAY 8
PY 2013
VL 5
IS 9
BP 3514
EP 3518
DI 10.1021/am400909g
PG 5
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
SC Science & Technology - Other Topics; Materials Science
GA 143AQ
UT WOS:000318839100005
PM 23611583
ER
PT J
AU Bates, ME
Keisler, JM
Jones, E
Linkov, I
AF Bates, Matthew E.
Keisler, Jeffrey M.
Jones, Elizabeth
Linkov, Igor
TI Risky Removal: Developing a Holistic Understanding of the Risks of
Redeveloping Sites Contaminated with Unexploded Ordnance
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Editorial Material
C1 [Bates, Matthew E.; Linkov, Igor] USA, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
[Keisler, Jeffrey M.] Univ Massachusetts, Boston, MA 02125 USA.
[Jones, Elizabeth] Univ Calif Berkeley, Berkeley, CA 94720 USA.
RP Linkov, I (reprint author), 696 Virginia Rd, Concord, MA 01742 USA.
EM Igor.Linkov@usace.army.mil
NR 4
TC 0
Z9 0
U1 0
U2 11
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD MAY 7
PY 2013
VL 47
IS 9
BP 3955
EP 3956
DI 10.1021/es401369s
PG 2
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 141WA
UT WOS:000318756000004
PM 23607512
ER
PT J
AU Giri, AK
Hirsh, G
Duncan, KJ
Karna, SP
Dennis, CL
AF Giri, Anit K.
Hirsh, Gary
Duncan, Kate J.
Karna, Shashi P.
Dennis, C. L.
TI Magnetic distributions of iron-(nickel zinc ferrite) nanocomposites from
first order reversal curve analysis
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
ID NI-ZN FERRITE; NANOPARTICLES; METAL; NUCLEATION; POLYOLS; GROWTH
AB First order reversal curve measurements offer a powerful approach to quantify the magnetic property distributions in materials. Here, we have used this approach to quantify magnetic property distributions and understand the nano-scale mechanisms contributing to the magnetic anisotropy of Fe-(Ni0.5Zn0.5)Fe2O4 nanocomposites. The Fe-(Ni0.5Zn0.5)Fe2O4 nanocomposite powders were synthesized using a chemical method involving ferrite precipitation and controlled reduction which resulted in the formation of iron nanoclusters within the ferrite. Two samples with a similar to 65% and similar to 6% iron composition, respectively, were studied. Transmission electron microscopy measurements yielded an average particle size of similar to 15nm (similar to 65% Fe) and similar to 60nm (similar to 6% Fe). The magnetizations at 7 T for the synthesized nanocomposites (M-7T = 58 Am-2 kg(-1) for the similar to 65% Fe sample and 55 Am-2 kg(-1) for the similar to 6% Fe sample) are close to that of the bulk saturation magnetization (similar to 60 Am-2 kg(-1)) of (Ni0.5Zn0.5)Fe2O4. This is not typical in these ferrite systems, due to poor crystallinity. In our samples, the observed large M-7T may result from the presence of the iron nanoclusters, as well as improved crystallinity. However, there is a slope to the magnetization at high fields which has typically been attributed to surface spin canting. This may instead be an indication of reduced crystallinity at the surface of the nanoparticles, especially in the similar to 65% Fe sample. Furthermore, a difference in interactions between the ferrite and the iron nanoclusters in the two samples results in different anisotropy distributions, as evidenced by a broad transition to saturation for the first sample, and a much sharper transition for the second sample, and confirmed through first order reversal curve measurements.
C1 [Giri, Anit K.; Hirsh, Gary; Karna, Shashi P.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Duncan, Kate J.] Communicat Elect Res, Ctr Dev & Engn, Space & Terr Communicat Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Dennis, C. L.] NIST, Mat Measurement Lab, Gaithersburg, MD 20899 USA.
RP Giri, AK (reprint author), USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM anit.giri.ctr@mail.mil
NR 17
TC 3
Z9 3
U1 1
U2 28
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0021-8979
EI 1089-7550
J9 J APPL PHYS
JI J. Appl. Phys.
PD MAY 7
PY 2013
VL 113
IS 17
AR 173908
DI 10.1063/1.4803545
PG 5
WC Physics, Applied
SC Physics
GA 149BK
UT WOS:000319292800363
ER
PT J
AU Giri, AK
Paterson, BA
McLeod, MV
Dennis, CL
Majumdar, BS
Cho, KC
Shull, RD
AF Giri, Anit K.
Paterson, Brigitte A.
McLeod, Michael V.
Dennis, Cindi L.
Majumdar, Bhaskar S.
Cho, Kyu C.
Shull, Robert D.
TI Effect of crystallographic alignment on the magnetocaloric effect in
alloys near the Ni2MnGa stoichiometry
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article; Proceedings Paper
CT 12th Joint MMM-Intermag Conference
CY JAN 14-18, 2013
CL Chicago, IL
SP AIP Publishing, IEEE Magnet Soc
ID NI-MN-GA; FIELD-INDUCED STRAIN; SHAPE-MEMORY
AB Prior to the development of commercial applications of magnetic refrigerator technology, a large magnetocaloric effect (MCE) in polycrystalline materials must be realized for relatively low magnetic field changes. To increase the MCE, a crystallographic alignment technique, consisting of thermal cycling about the martensite phase transition temperature under a compressive stress, was applied to Heusler alloys with nominal composition Ni2+xMn1-xGa (x = 0.14, 0.16). Magnetic measurements prior to grain alignment show that the maximum entropy changes of -16 J kg(-1) K-1 and -24 J kg(-1) K-1 for samples with x = 0.14 and 0.16, respectively, occurred for a magnetic field change of 7 T. After grain alignment, there was a 56%-79% enhancement of the maximum magnetic entropy change for the same magnetic field change of 7 T. This suggests that thermal cycling under compressive stress may either increase grain alignment (e. g., texture) along the magnetic easy (001) axis, and/or enhance the ease with which a magnetic field is later able to grow favorably oriented twin variants that manifests as an increase of magnetization of the material. Therefore, such an alignment technique may be utilized to enhance the MCE of similar Heusler alloys.
C1 [Giri, Anit K.; Cho, Kyu C.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Paterson, Brigitte A.; Dennis, Cindi L.; Shull, Robert D.] NIST, Mat Measurement Lab, Gaithersburg, MD 20899 USA.
[McLeod, Michael V.; Majumdar, Bhaskar S.] New Mexico Inst Min & Technol, Dept Mat & Met Engn, Socorro, NM 87801 USA.
RP Giri, AK (reprint author), USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM anit.giri.ctr@mail.mil
NR 11
TC 6
Z9 6
U1 2
U2 26
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0021-8979
EI 1089-7550
J9 J APPL PHYS
JI J. Appl. Phys.
PD MAY 7
PY 2013
VL 113
IS 17
AR 17A907
DI 10.1063/1.4793608
PG 3
WC Physics, Applied
SC Physics
GA 149BK
UT WOS:000319292800052
ER
PT J
AU Memisevic, V
Wallqvist, A
Reifman, J
AF Memisevic, Vesna
Wallqvist, Anders
Reifman, Jaques
TI Reconstituting protein interaction networks using parameter-dependent
domain-domain interactions
SO BMC BIOINFORMATICS
LA English
DT Article
DE Merging domain annotations; Domain-domain interactions; Protein-protein
interaction networks
ID SACCHAROMYCES-CEREVISIAE; GENOME SEQUENCES; DATABASE; PREDICTION;
FAMILIES; IDENTIFICATION; FRAMEWORK; RESOURCE; INTERPRO; SMART
AB Background: We can describe protein-protein interactions (PPIs) as sets of distinct domain-domain interactions (DDIs) that mediate the physical interactions between proteins. Experimental data confirm that DDIs are more consistent than their corresponding PPIs, lending support to the notion that analyses of DDIs may improve our understanding of PPIs and lead to further insights into cellular function, disease, and evolution. However, currently available experimental DDI data cover only a small fraction of all existing PPIs and, in the absence of structural data, determining which particular DDI mediates any given PPI is a challenge.
Results: We present two contributions to the field of domain interaction analysis. First, we introduce a novel computational strategy to merge domain annotation data from multiple databases. We show that when we merged yeast domain annotations from six annotation databases we increased the average number of domains per protein from 1.05 to 2.44, bringing it closer to the estimated average value of 3. Second, we introduce a novel computational method, parameter-dependent DDI selection (PADDS), which, given a set of PPIs, extracts a small set of domain pairs that can reconstruct the original set of protein interactions, while attempting to minimize false positives. Based on a set of PPIs from multiple organisms, our method extracted 27% more experimentally detected DDIs than existing computational approaches.
Conclusions: We have provided a method to merge domain annotation data from multiple sources, ensuring large and consistent domain annotation for any given organism. Moreover, we provided a method to extract a small set of DDIs from the underlying set of PPIs and we showed that, in contrast to existing approaches, our method was not biased towards DDIs with low or high occurrence counts. Finally, we used these two methods to highlight the influence of the underlying annotation density on the characteristics of extracted DDIs. Although increased annotations greatly expanded the possible DDIs, the lack of knowledge of the true biological false positive interactions still prevents an unambiguous assignment of domain interactions responsible for all protein network interactions.
Executable files and examples are given at: http://www.bhsai.org/downloads/padds/
C1 [Memisevic, Vesna; Wallqvist, Anders; Reifman, Jaques] US Army Med Res & Mat Command, Dept Def Biotechnol, High Performance Comp Software Appl Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA.
RP Reifman, J (reprint author), US Army Med Res & Mat Command, Dept Def Biotechnol, High Performance Comp Software Appl Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA.
EM jaques.reifman.civ@mail.mil
OI wallqvist, anders/0000-0002-9775-7469
FU U.S. Army Medical Research and Materiel Command, Ft. Detrick, Maryland,
U.S. Army's Network Science Initiative
FX The authors were supported by the Military Operational Medicine Research
Program of the U.S. Army Medical Research and Materiel Command, Ft.
Detrick, Maryland, as part of the U.S. Army's Network Science
Initiative. The opinions and assertions contained herein are the private
views of the authors and are not to be construed as official or as
reflecting the views of the U. S. Army or the U. S. Department of
Defense. This paper has been approved for public release with unlimited
distribution.
NR 47
TC 8
Z9 8
U1 0
U2 11
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2105
J9 BMC BIOINFORMATICS
JI BMC Bioinformatics
PD MAY 7
PY 2013
VL 14
AR 154
DI 10.1186/1471-2105-14-154
PG 15
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
Mathematical & Computational Biology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Mathematical & Computational Biology
GA 147XZ
UT WOS:000319206100001
PM 23651452
ER
PT J
AU Chaccour, CJ
Kobylinski, KC
Bassat, Q
Bousema, T
Drakeley, C
Alonso, P
Foy, BD
AF Chaccour, Carlos J.
Kobylinski, Kevin C.
Bassat, Quique
Bousema, Teun
Drakeley, Chris
Alonso, Pedro
Foy, Brian D.
TI Ivermectin to reduce malaria transmission: a research agenda for a
promising new tool for elimination
SO MALARIA JOURNAL
LA English
DT Article
DE Malaria elimination; Ivermectin; Endectocides; Vector control
ID ANOPHELES-GAMBIAE; MASS TREATMENT; PLASMODIUM-FALCIPARUM; ARTEMISININ
RESISTANCE; ONCHOCERCA-VOLVULUS; PREGNANCY; MOSQUITOS; VECTOR; BLOOD;
QUADRIMACULATUS
AB Background: The heterogeneity of malaria transmission makes widespread elimination a difficult goal to achieve. Most of the current vector control measures insufficiently target outdoor transmission. Also, insecticide resistance threatens to diminish the efficacy of the most prevalent measures, indoor residual spray and insecticide treated nets. Innovative approaches are needed. The use of endectocides, such as ivermectin, could be an important new addition to the toolbox of anti-malarial measures. Ivermectin effectively targets outdoor transmission, has a novel mechanism of action that could circumvent resistance and might be distributed over the channels already in place for the control of onchocerciasis and lymphatic filariasis.
Methods: The previous works involving ivermectin and Anopheles vectors are reviewed and summarized. A review of ivermectin's safety profile is also provided. Finally three definitive clinical trials are described in detail and proposed as the evidence needed for implementation. Several smaller and specific supportive studies are also proposed.
Conclusions: The use of ivermectin solves many challenges identified for future vector control strategies. It is an effective and safe endectocide that was approved for human use more than 25 years ago. Recent studies suggest it might become an effective and complementary strategy in malaria elimination and eradication efforts; however, intensive research will be needed to make this a reality.
C1 [Chaccour, Carlos J.] Univ Navarra Clin, Dept Internal Med, Pamplona 31008, Spain.
[Chaccour, Carlos J.] Univ Navarra, Inst Salud Trop, E-31080 Pamplona, Spain.
[Kobylinski, Kevin C.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD USA.
[Bassat, Quique; Alonso, Pedro] Univ Barcelona, Hosp Clin, CRESIB, Barcelona Ctr Int Hlth Res, Barcelona, Spain.
[Bassat, Quique; Alonso, Pedro] CISM, Maputo, Mozambique.
[Bousema, Teun; Drakeley, Chris] London Sch Hyg & Trop Med, Fac Infect & Trop Dis, Dept Immunol & Infect, London WC1, England.
[Bousema, Teun] Radboud Univ Nijmegen, Nijmegen Med Ctr, Dept Med Microbiol, NL-6525 ED Nijmegen, Netherlands.
[Foy, Brian D.] Colorado State Univ, Dept Microbiol Immunol & Pathol, Arthropod Borne & Infect Dis Lab, Ft Collins, CO 80523 USA.
RP Chaccour, CJ (reprint author), Univ Navarra Clin, Dept Internal Med, Av Pio 12 36, Pamplona 31008, Spain.
EM cchaccour@unav.es; Brian.Foy@ColoState.EDU
RI Bousema, Teun/N-3574-2014; Bassat, Quique/P-2341-2016; Foy,
Brian/E-6230-2017
OI Bassat, Quique/0000-0003-0875-7596; Foy, Brian/0000-0002-9117-203X
FU US National Institutes of Health-National Institute of Allergy and
Infectious Diseases [1R01AI094349-01A1]
FX BDF was supported by grant 1R01AI094349-01A1 from the US National
Institutes of Health-National Institute of Allergy and Infectious
Diseases. The opinions or assertions contained herein are the private
views of the authors, and are not to be construed as official, or as
reflecting true views of the US Department of the Army or the Department
of Defense. We thank Juliane Chaccour for proofreading the manuscript.
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PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD MAY 7
PY 2013
VL 12
AR 153
DI 10.1186/1475-2875-12-153
PG 8
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 147SO
UT WOS:000319187500001
PM 23647969
ER
PT J
AU Kirste, R
Mita, S
Hussey, L
Hoffmann, MP
Guo, W
Bryan, I
Bryan, Z
Tweedie, J
Xie, JQ
Gerhold, M
Collazo, R
Sitar, Z
AF Kirste, Ronny
Mita, Seiji
Hussey, Lindsay
Hoffmann, Marc P.
Guo, Wei
Bryan, Isaac
Bryan, Zachary
Tweedie, James
Xie, Jinqiao
Gerhold, Michael
Collazo, Ramon
Sitar, Zlatko
TI Polarity control and growth of lateral polarity structures in AlN
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID INVERSION DOMAINS; SAPPHIRE; GAN; EPILAYERS
AB The control of the polarity of metalorganic chemical vapor deposition grown AlN on sapphire is demonstrated. Al-polar and N-polar AlN is grown side-by-side yielding a lateral polarity structure. Scanning electron microscopy measurements reveal a smooth surface for the Al-polar and a relatively rough surface for the N-polar AlN domains. Transmission electron microscopy shows mixed edge-screw type dislocations with polarity-dependent dislocation bending. Raman spectroscopy reveals compressively strained Al-polar and relaxed N-polar domains. The near band edge luminescence consists of free and bound excitons which are broadened for the Al-polar AlN. Relaxation, better optical quality, and dislocation bending in the N-polar domains are explained by the columnar growth mode. (C) 2013 AIP Publishing LLC.
C1 [Kirste, Ronny; Hussey, Lindsay; Hoffmann, Marc P.; Guo, Wei; Bryan, Isaac; Bryan, Zachary; Tweedie, James; Collazo, Ramon; Sitar, Zlatko] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA.
[Mita, Seiji; Xie, Jinqiao] HexaTech Inc, Morrisville, NC 27560 USA.
[Gerhold, Michael] USA, Res Off, Engn Sci Directorate, Res Triangle Pk, NC 27703 USA.
RP Kirste, R (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA.
FU Army Research Laboratory [W911NF-04-D-0003]; William Clark program
monitor; NSF [DMR-1108071]
FX This work was supported in part by the Army Research Laboratory
(Contract No. W911NF-04-D-0003), William Clark program monitor, and NSF
under Contract No. DMR-1108071. We thank Professor Axel Hoffmann of TU
Berlin for the support in the Raman spectroscopy measurements.
NR 25
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PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0003-6951
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD MAY 6
PY 2013
VL 102
IS 18
AR 181913
DI 10.1063/1.4804575
PG 4
WC Physics, Applied
SC Physics
GA 164VV
UT WOS:000320439900035
ER
PT J
AU Borodin, O
Behl, W
Jow, TR
AF Borodin, Oleg
Behl, Wishvender
Jow, T. Richard
TI Oxidative Stability and Initial Decomposition Reactions of Carbonate,
Sulfone, and Alkyl Phosphate-Based Electrolytes
SO JOURNAL OF PHYSICAL CHEMISTRY C
LA English
DT Article
ID LI-ION BATTERIES; DENSITY-FUNCTIONAL THEORY; MOLECULAR-DYNAMICS
SIMULATION; ELECTROCHEMICAL PROPERTIES; ANODIC STABILITY; AIR BATTERIES;
LIQUID ELECTROLYTES; PROPYLENE CARBONATE; LITHIUM BATTERIES; REDOX
SHUTTLES
AB The oxidative stability and initial oxidation-induced decomposition reactions of common electrolyte solvents for batteries and electrical double layer capacitors were investigated using quantum chemistry (QC) calculations. The investigated electrolytes consisted of linear (DMC, EMC) and cyclic carbonate (EC, PC, VC), sulfone (TMS), sulfonate, and alkyl phosphate solvents paired with BF4-, PF6-, bis-(fluorosulfonyl)imide (FSI-), difluoro-(oxalato)borate (DFOB-), dicyanotriazolate.(DCTA(-)), and B(CN)(4)(-) anions. Most QC calculations were performed using the MOS-.2X, LC-omega PBE. density functional and compared with the G4MP2 results where feasible. The calculated oxidation potentials were compared with previous and new experimental data The intrinsic oxidation potential of most solvent molecules was found to be higher than experimental values for electrolytes even after the solvation contribution was included in the QC calculations via a polarized continuum model The presence of BF4-, PF6-, B(CN)(4)(-); and FSI- anions near the solvents was found to significantly decrease the oxidative stability of Many solvents due to the spontaneous or low barrier (for FSI-) H- and F-abstraction reaction that followed the initial electron removal step; Such Spontaneous H-abstraction reactions were not observed for the solvent complexes with DCTA(-) or DFOB- anions or for VC/anion, TMP/PF6- complexes Spontaneous H-transfer reactions were also found for dimers of the oxidized carbonates (EC, DMC), alkyl phosphates. (TMP), while low bather H-transfer was found for (timers of sulfones (TMS and EMS). These reactions resulted in a significant decrease of the dimer oxidation potential compared to the oxidation potential of the isolated solvent molecules. The presence of anions or an explicitly included solvent molecule next to the oxidized solvent molecules also reduced the barriers for the oxidation-induced decomposition reaction and often changed the decomposition products. When a Li+ cation polarized the solvent in the ECn/LiBF4 and ECn/LiPF6 complexes, the complex oxidation potential was 0.3-0.6. eV higher than the oxidation potential of ECn/BF4-. and ECn/PF6-.
C1 [Borodin, Oleg; Behl, Wishvender; Jow, T. Richard] USA, Res Lab, Electrochem Branch, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Borodin, O (reprint author), USA, Res Lab, Electrochem Branch, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM oleg.a.borodin.civ@mail.mil
RI Borodin, Oleg/B-6855-2012
OI Borodin, Oleg/0000-0002-9428-5291
FU U.S. Department of Energy [DE-IA01-11EE003413]; U.S. Army Research
Laboratory [DE-IA01-11EE003413]
FX This work was supported via an Interagency Agreement between the U.S.
Department of Energy and the U.S. Army Research Laboratory under
DE-IA01-11EE003413 for the Office of Vehicle Technologies Programs,
including the ARB and BATT Programs. Computational resources from the
DoD's High Performance Computing Modernization Program (HPCMP) are
acknowledged.
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PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1932-7447
EI 1932-7455
J9 J PHYS CHEM C
JI J. Phys. Chem. C
PD MAY 2
PY 2013
VL 117
IS 17
BP 8661
EP 8682
DI 10.1021/jp400527c
PG 22
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA 138UX
UT WOS:000318536600010
ER
PT J
AU He, QG
Li, Q
Khene, S
Ren, XM
Lopez-Suarez, FE
Lozano-Castello, D
Bueno-Lopez, A
Wu, G
AF He, Qinggang
Li, Qing
Khene, Samson
Ren, Xiaoming
Lopez-Suarez, Franz E.
Lozano-Castello, Dolores
Bueno-Lopez, Agustin
Wu, Gang
TI High-Loading Cobalt Oxide Coupled with Nitrogen-Doped Graphene for
Oxygen Reduction in Anion-Exchange-Membrane Alkaline Fuel Cells
SO JOURNAL OF PHYSICAL CHEMISTRY C
LA English
DT Article
ID TRANSITION-METAL CHALCOGENIDES; ONION-LIKE CARBON; ELECTROCHEMICAL
REDUCTION; METHANOL ELECTROOXIDATION; HEAT-TREATMENT; O-2 REDUCTION;
CATALYSTS; ELECTROCATALYSTS; PERFORMANCE; NANOPARTICLES
AB A new nanocomposite catalyst consisting of high loading cobalt oxide (CoO) on nitrogen doped reduced graphene oxide (rGO) for oxygen reduction reaction (ORR) was prepared in this work Its high activity for the ORR in alkaline electrolyte was determined using the rotating disk electrode technique, and further confirmed in real alkaline membrane fuel cells. A combination of physicochemical characterization (e.g., X-ray absorption and X-ray photoelectron spectra) and density functional theory (DFT) calculation suggests that cobalt(II) cations in the composite catalyst may coordinate with the pyridinic nitrogen atoms doped into graphene planes, most likely the active species for the ORR Especially, the DFT calculations indicate that a stable rGO(N)-Co(II)-O-Co(II)-rGO(N) structure can be formed in the nitrogen-doped graphene catalist. Kinetic parameter analysis shows a high selectivity of four electron reduction on the composite catalyst during the ORR with an average electron transfer number of 3.75. A synergistic effect between the rGO(N) and CoO may exist, yielding a much higher catalytic activity on the CoO/rGO(N) catalyst, compared to either rGO(N) or CoO controls. The novel synthesis procedure utilizing rGO(N) to further couple Co(II) yields a high loading of Co species (24.7 wt %). Thus, a relatively thinner cathode in fuel cell can accommodate more active Co species and facilitate O-2 transfer. Due to the high intrinsic activity and efficient mass transport, the CoO-rGO(N) ORR catalyst achieved approaching performance to state-of-the-art Pt/C cathodes in anion-exchange-membrane alkaline fuel cells.
C1 [He, Qinggang] Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA.
[Li, Qing; Wu, Gang] Los Alamos Natl Lab, Mat Phys & Applicat Div, Los Alamos, NM 87545 USA.
[Khene, Samson] Rhodes Univ, Dept Chem, ZA-6140 Grahamstown, South Africa.
[Ren, Xiaoming] USA, Res Lab, Adelphi, MD 20783 USA.
[Lopez-Suarez, Franz E.; Lozano-Castello, Dolores; Bueno-Lopez, Agustin] Univ Alicante, Dept Inorgan Chem, E-03080 Alicante, Spain.
RP He, QG (reprint author), Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA.
EM QHe@mednet.ucla.edu; wugang@lanl.gov
RI Wu, Gang/E-8536-2010; Li, Qing/G-4502-2011; ren, xiaoming/F-3953-2011;
He, Qinggang/O-7639-2014;
OI Wu, Gang/0000-0003-4956-5208; Li, Qing/0000-0003-4807-030X; He,
Qinggang/0000-0002-7693-8017; Lopez-Suarez, Franz E/0000-0003-2670-7509;
Bueno Lopez, Agustin/0000-0002-5434-6459
FU Los Alamos National Laboratory Early Career Laboratory-Directed Research
and Development (LDRD) Program
FX We would like to thank B. Shyam and F. McLarnon for helpful comments and
suggestions during preparation of this manuscript. The financial support
from the Los Alamos National Laboratory Early Career Laboratory-Directed
Research and Development (LDRD) Program for this work is gratefully
acknowledged.
NR 69
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PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1932-7447
J9 J PHYS CHEM C
JI J. Phys. Chem. C
PD MAY 2
PY 2013
VL 117
IS 17
BP 8697
EP 8707
DI 10.1021/jp401814f
PG 11
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA 138UX
UT WOS:000318536600013
ER
PT J
AU Johnson, BD
van Helmond, N
Curry, TB
Convertino, VA
Joyner, MJ
AF Johnson, Blair D.
van Helmond, Noud
Curry, Timothy B.
Convertino, Victor A.
Joyner, Michael J.
TI Relationship Of Central Venous Pressure To Hemodynamic Responses During
Lower Body Negative Pressure And Hemorrhage
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
CT 60th Annual Meeting of the American-College-of-Sports-Medicine
CY MAY 28-JUN 01, 2013
CL Indianapolis, IN
SP Amer Coll Sports Med
C1 [Johnson, Blair D.; Curry, Timothy B.; Joyner, Michael J.] Mayo Clin, Rochester, MN USA.
[van Helmond, Noud] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands.
[Convertino, Victor A.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
NR 0
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PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2013
VL 45
IS 5
SU 1
MA 216
BP 39
EP 39
PG 1
WC Sport Sciences
SC Sport Sciences
GA 300ND
UT WOS:000330469700118
ER
PT J
AU DeGroot, D
Kenefick, RW
Sawka, MN
AF DeGroot, David
Kenefick, Robert W.
Sawka, Michael N.
TI Extremity Cooling Reduces Exertional Heat Injury Severity During
Military Training
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
CT 60th Annual Meeting of the American-College-of-Sports-Medicine
CY MAY 28-JUN 01, 2013
CL Indianapolis, IN
SP Amer Coll Sports Med
C1 [DeGroot, David] US Army Publ Hlth Command, Aderbeen, MD USA.
[Kenefick, Robert W.; Sawka, Michael N.] US Army Res Inst Environm Med, Natick, MA USA.
NR 0
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PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2013
VL 45
IS 5
SU 1
MA 298
BP 65
EP 65
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SC Sport Sciences
GA 300ND
UT WOS:000330469700200
ER
PT J
AU Cuddy, J
Buller, M
Hailes, W
Ruby, B
AF Cuddy, John
Buller, Mark
Hailes, Walter
Ruby, Brent
TI Skin Temperature And Heart Rate Estimate Physiological Strain During
Exercise In The Heat
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
CT 60th Annual Meeting of the American-College-of-Sports-Medicine
CY MAY 28-JUN 01, 2013
CL Indianapolis, IN
SP Amer Coll Sports Med
C1 [Cuddy, John; Hailes, Walter; Ruby, Brent] Univ Montana, Missoula, MT 59812 USA.
[Buller, Mark] US Army Res Inst Environm Med, Natick, MA USA.
NR 0
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U1 1
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PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2013
VL 45
IS 5
SU 1
MA 1000
BP 215
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SC Sport Sciences
GA 300ND
UT WOS:000330469701352
ER
PT J
AU Cameron, KL
Campbell, SE
Peck, KY
Westrick, RB
Owens, BD
AF Cameron, Kenneth L.
Campbell, Scot E.
Peck, Karen Y.
Westrick, Richard B.
Owens, Brett D.
TI Extreme Glenoid Retroversion is Associated with Increased Rotator Cuff
Strength in the Shoulder
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
CT 60th Annual Meeting of the American-College-of-Sports-Medicine
CY MAY 28-JUN 01, 2013
CL Indianapolis, IN
SP Amer Coll Sports Med
C1 [Cameron, Kenneth L.; Campbell, Scot E.; Peck, Karen Y.; Westrick, Richard B.; Owens, Brett D.] US Mil Acad, Keller Army Hosp, West Point, NY 10996 USA.
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PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2013
VL 45
IS 5
SU 1
MA 1092
BP 240
EP 241
PG 2
WC Sport Sciences
SC Sport Sciences
GA 300ND
UT WOS:000330469702042
ER
PT J
AU Asplund, C
AF Asplund, Chad
TI Exercise Related Syncope In Active Duty Soldiers
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
CT 60th Annual Meeting of the American-College-of-Sports-Medicine
CY MAY 28-JUN 01, 2013
CL Indianapolis, IN
SP Amer Coll Sports Med
C1 [Asplund, Chad] Eisenhower Army Med Ctr, Ft Gordon, GA USA.
NR 0
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PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2013
VL 45
IS 5
SU 1
MA 1124
BP 250
EP 250
PG 1
WC Sport Sciences
SC Sport Sciences
GA 300ND
UT WOS:000330469702074
ER
PT J
AU Sauer, SG
Fellin, RE
Frykman, PN
Seay, JF
AF Sauer, Shane G.
Fellin, Rebecca E.
Frykman, Peter N.
Seay, Joseph F.
TI Knee Moments Do Not Increase Proportionally To The Load Carried While
Walking
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
CT 60th Annual Meeting of the American-College-of-Sports-Medicine
CY MAY 28-JUN 01, 2013
CL Indianapolis, IN
SP Amer Coll Sports Med
C1 [Sauer, Shane G.; Fellin, Rebecca E.; Frykman, Peter N.; Seay, Joseph F.] US Army Res Inst Environm Med, Natick, MA USA.
NR 0
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PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2013
VL 45
IS 5
SU 1
MA 1371
BP 309
EP 309
PG 1
WC Sport Sciences
SC Sport Sciences
GA 300ND
UT WOS:000330469702275
ER
PT J
AU Simpson, K
Hendrickson, NR
Redmond, JE
Cohen, BS
Spiering, BA
Knapik, JJ
Sharp, MA
AF Simpson, Kathleen
Hendrickson, Nathan R.
Redmond, Jan E.
Cohen, Bruce S.
Spiering, Barry A.
Knapik, Joseph J.
Sharp, Marilyn A.
TI Intensity of Physical Activity Performed During US Army Basic Combat
Training
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
CT 60th Annual Meeting of the American-College-of-Sports-Medicine
CY MAY 28-JUN 01, 2013
CL Indianapolis, IN
SP Amer Coll Sports Med
C1 [Simpson, Kathleen; Hendrickson, Nathan R.; Redmond, Jan E.; Cohen, Bruce S.; Spiering, Barry A.; Sharp, Marilyn A.] US Army Res Inst Environm Med, Natick, MA USA.
[Knapik, Joseph J.] US Army Inst Publ Hlth, Aberdeen Proving Ground, MD USA.
NR 0
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PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2013
VL 45
IS 5
SU 1
MA 1426
BP 325
EP 325
PG 1
WC Sport Sciences
SC Sport Sciences
GA 300ND
UT WOS:000330469702320
ER
PT J
AU Delasobera, BE
Shelley, N
Robinson, S
Ho, G
Howard, T
AF Delasobera, Bronson Elizabeth
Shelley, Neal
Robinson, Scott
Ho, Garry
Howard, Thomas
TI Platelet Rich Plasma: Improvement in Pain by Anatomical Site and Number
of Injections
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
CT 60th Annual Meeting of the American-College-of-Sports-Medicine
CY MAY 28-JUN 01, 2013
CL Indianapolis, IN
SP Amer Coll Sports Med
C1 [Delasobera, Bronson Elizabeth; Shelley, Neal] Georgetown Univ, Washington, DC USA.
[Robinson, Scott] US Army, Lacey, WA USA.
[Ho, Garry; Howard, Thomas] Virginia Commonwealth Univ, Fairfax, VA USA.
NR 0
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PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2013
VL 45
IS 5
SU 1
MA 1506
BP 349
EP 349
PG 1
WC Sport Sciences
SC Sport Sciences
GA 300ND
UT WOS:000330469702400
ER
PT J
AU Cosio-Lima, LM
Brown, K
Reynolds, K
Perry, RA
AF Cosio-Lima, Ludmila M.
Brown, Kathleen
Reynolds, Katy
Perry, Ricky A.
TI Physical Training-Related Injuries And Illnesses In A Sergeants Major
Academy Class
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
CT 60th Annual Meeting of the American-College-of-Sports-Medicine
CY MAY 28-JUN 01, 2013
CL Indianapolis, IN
SP Amer Coll Sports Med
C1 [Cosio-Lima, Ludmila M.; Reynolds, Katy; Perry, Ricky A.] Univ W Florida, Pensacola, FL 32514 USA.
[Brown, Kathleen] US ARMY, Natick, MA USA.
NR 0
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PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2013
VL 45
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SU 1
MA 1718
BP 393
EP 393
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SC Sport Sciences
GA 300ND
UT WOS:000330469703134
ER
PT J
AU Hibberd, EE
Shutt, CE
Oyama, S
Blackburn, JT
Myers, JB
AF Hibberd, Elizabeth E.
Shutt, Casey E.
Oyama, Sakiko
Blackburn, J. Troy
Myers, Joseph B.
TI Physical Contributors to Glenohumeral Internal Rotation Deficit in High
School Baseball Players
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
CT 60th Annual Meeting of the American-College-of-Sports-Medicine
CY MAY 28-JUN 01, 2013
CL Indianapolis, IN
SP Amer Coll Sports Med
C1 [Hibberd, Elizabeth E.; Blackburn, J. Troy; Myers, Joseph B.] Univ N Carolina, Chapel Hill, NC USA.
[Shutt, Casey E.] US Army Baylor Univ, San Antonio, TX USA.
[Oyama, Sakiko] Univ Texas San Antonio, San Antonio, TX USA.
NR 0
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PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2013
VL 45
IS 5
SU 1
MA 1722
BP 394
EP 394
PG 1
WC Sport Sciences
SC Sport Sciences
GA 300ND
UT WOS:000330469703138
ER
PT J
AU Bushman, TT
Grier, T
Chervak, M
Anderson, M
Jones, B
AF Bushman, Timothy T.
Grier, Tyson
Chervak, Michelle
Anderson, Morgan
Jones, Bruce
TI Association of Physical Fitness Assessments and Injury Risk among US
Army Soldiers
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
CT 60th Annual Meeting of the American-College-of-Sports-Medicine
CY MAY 28-JUN 01, 2013
CL Indianapolis, IN
SP Amer Coll Sports Med
C1 [Bushman, Timothy T.; Grier, Tyson; Chervak, Michelle; Anderson, Morgan; Jones, Bruce] US Army, Inst Publ Hlth, Aberdeen Proving Ground, MD USA.
NR 0
TC 0
Z9 0
U1 2
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2013
VL 45
IS 5
SU 1
MA 1728
BP 396
EP 396
PG 1
WC Sport Sciences
SC Sport Sciences
GA 300ND
UT WOS:000330469703143
ER
PT J
AU Warr, BJ
Fellin, RE
Frykman, PN
Sauer, SG
Goss, DL
Seay, JJ
AF Warr, Bradley J.
Fellin, Rebecca E.
Frykman, Peter N.
Sauer, Shane G.
Goss, Donald L.
Seay, Joseph J.
TI No Differences in Self-reported Injuries or Performance Between
Characterized Foot-strike Patterns Amongst US Army Soldiers
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
CT 60th Annual Meeting of the American-College-of-Sports-Medicine
CY MAY 28-JUN 01, 2013
CL Indianapolis, IN
SP Amer Coll Sports Med
C1 [Warr, Bradley J.; Fellin, Rebecca E.; Frykman, Peter N.; Sauer, Shane G.; Seay, Joseph J.] US Army, Environm Med Res Inst, Natick, MA USA.
[Goss, Donald L.] Baylor Univ, US Army, Phys Therapy Program, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2013
VL 45
IS 5
SU 1
MA 1734
BP 398
EP 398
PG 1
WC Sport Sciences
SC Sport Sciences
GA 300ND
UT WOS:000330469703148
ER
PT J
AU Asplund, C
AF Asplund, Chad
TI Exercise Related Syncope In Active Duty Soldiers
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
CT 60th Annual Meeting of the American-College-of-Sports-Medicine
CY MAY 28-JUN 01, 2013
CL Indianapolis, IN
SP Amer Coll Sports Med
C1 [Asplund, Chad] Eisenhower Army Med Ctr, Ft Gordon, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2013
VL 45
IS 5
SU 1
MA 1820
BP 422
EP 422
PG 1
WC Sport Sciences
SC Sport Sciences
GA 300ND
UT WOS:000330469703213
ER
PT J
AU Fellin, RE
Seay, JF
Hill, RD
Saldana, S
Cannon, DW
DeVita, P
Ip, EH
Martin, DF
Messier, SP
AF Fellin, Rebecca E.
Seay, Joseph F.
Hill, Ryan D.
Saldana, Santiago
Cannon, D. Wayne
DeVita, Paul
Ip, Edward H.
Martin, David F.
Messier, Stephen P.
TI Differences in Running Mechanics and Strength between Runners in
Minimalist and Traditional Footwear
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
CT 60th Annual Meeting of the American-College-of-Sports-Medicine
CY MAY 28-JUN 01, 2013
CL Indianapolis, IN
SP Amer Coll Sports Med
C1 [Fellin, Rebecca E.; Seay, Joseph F.] US Army Res Inst Environm Med, Natick, MA USA.
[Hill, Ryan D.; Messier, Stephen P.] Wake Forest Univ, Winston Salem, NC 27109 USA.
[Saldana, Santiago; Ip, Edward H.; Martin, David F.] Wake Forest Sch Med, Winston Salem, NC USA.
[Cannon, D. Wayne] Wayne Cannon Phys Therapy & Associates, Winston Salem, NC USA.
[DeVita, Paul] E Carolina Univ, Greenville, NC USA.
NR 0
TC 0
Z9 0
U1 1
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2013
VL 45
IS 5
SU 1
MA 1873
BP 424
EP 424
PG 1
WC Sport Sciences
SC Sport Sciences
GA 300ND
UT WOS:000330469703217
ER
PT J
AU Mayhew, JL
Schumacher, RM
Mann, B
Brechue, WF
Clasey, JL
Piper, FC
AF Mayhew, Jerry L.
Schumacher, Richard M.
Mann, Bryan
Brechue, William F.
Clasey, Jody L.
Piper, Fontaine C.
TI Comparison Of Techniques For Estimating DXA %fat In NCAA Division II
Male Athletes
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
CT 60th Annual Meeting of the American-College-of-Sports-Medicine
CY MAY 28-JUN 01, 2013
CL Indianapolis, IN
SP Amer Coll Sports Med
C1 [Mayhew, Jerry L.; Schumacher, Richard M.; Piper, Fontaine C.] Truman State Univ, Kirksville, MO USA.
[Mann, Bryan] Univ Missouri, Columbia, MO USA.
[Brechue, William F.] US Mil Acad, West Point, NY 10996 USA.
[Clasey, Jody L.] Univ Kentucky, Lexington, KY USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2013
VL 45
IS 5
SU 1
MA 1950
BP 447
EP 447
PG 1
WC Sport Sciences
SC Sport Sciences
GA 300ND
UT WOS:000330469703281
ER
PT J
AU Schumacher, RM
Mayhew, JL
Piper, FC
Mann, B
Brechue, WF
Clasey, JL
Smith-Ryan, AE
AF Schumacher, Richard M.
Mayhew, Jerry L.
Piper, Fontaine C.
Mann, Bryan
Brechue, William F.
Clasey, Jody L.
Smith-Ryan, Abbie E.
TI Validation of BIA and Skinfold Prediction Equations to Estimate Body
Composition in College Football Players
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
CT 60th Annual Meeting of the American-College-of-Sports-Medicine
CY MAY 28-JUN 01, 2013
CL Indianapolis, IN
SP Amer Coll Sports Med
C1 [Schumacher, Richard M.; Mayhew, Jerry L.; Piper, Fontaine C.] Truman State Univ, Kirksville, MO USA.
[Mann, Bryan] Univ Missouri, Columbia, MO USA.
[Brechue, William F.] US Mil Acad, West Point, NY 10996 USA.
[Clasey, Jody L.] Univ Kentucky, Lexington, KY USA.
[Smith-Ryan, Abbie E.] Univ N Carolina, Chapel Hill, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2013
VL 45
IS 5
SU 1
MA 1949
BP 447
EP 447
PG 1
WC Sport Sciences
SC Sport Sciences
GA 300ND
UT WOS:000330469703280
ER
PT J
AU Kobermann, AM
Galloway, WC
Allen, WM
Mayhew, JL
Leahy, GD
Crowder, TA
AF Kobermann, Andrea M.
Galloway, Warren C.
Allen, Wesley M.
Mayhew, Jerry L.
Leahy, Guy D.
Crowder, Todd A.
TI Relationship of Body Composition Measurement Techniques with Physical
Fitness Tests in College ROTC Cadets
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
CT 60th Annual Meeting of the American-College-of-Sports-Medicine
CY MAY 28-JUN 01, 2013
CL Indianapolis, IN
SP Amer Coll Sports Med
C1 [Kobermann, Andrea M.; Galloway, Warren C.; Allen, Wesley M.; Mayhew, Jerry L.] Truman State Univ, Kirksville, MO USA.
[Leahy, Guy D.] Davis Monthan Air Force Base, Tucson, AZ USA.
[Crowder, Todd A.] US Mil Acad, West Point, NY 10996 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2013
VL 45
IS 5
SU 1
MA 2448
BP 579
EP 579
PG 1
WC Sport Sciences
SC Sport Sciences
GA 300ND
UT WOS:000330469704340
ER
PT J
AU Crowder, TA
Ferrara, AL
Levinbook, MD
AF Crowder, Todd A.
Ferrara, Andrew L.
Levinbook, Max D.
TI Comparing the APFT and a Military Optimal Performance Challenge Related
to Body Mass and Potential Military Readiness
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
CT 60th Annual Meeting of the American-College-of-Sports-Medicine
CY MAY 28-JUN 01, 2013
CL Indianapolis, IN
SP Amer Coll Sports Med
C1 [Crowder, Todd A.] US Mil Acad, West Point, NY 10996 USA.
[Ferrara, Andrew L.; Levinbook, Max D.] US Army, Schofield Barracks, HI USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2013
VL 45
IS 5
SU 1
MA 2454
BP 580
EP 581
PG 2
WC Sport Sciences
SC Sport Sciences
GA 300ND
UT WOS:000330469704346
ER
PT J
AU Leahy, GD
Crowder, TA
Mayhew, JL
AF Leahy, Guy D.
Crowder, Todd A.
Mayhew, Jerry L.
TI Comparison of Fitness Performance Tests between Air Force Active Duty
and National Guard Men between 18 and 59 Years Old
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
CT 60th Annual Meeting of the American-College-of-Sports-Medicine
CY MAY 28-JUN 01, 2013
CL Indianapolis, IN
SP Amer Coll Sports Med
C1 [Leahy, Guy D.] Davis Monthan Air Force Base, Tucson, AZ USA.
[Crowder, Todd A.] US Mil Acad, West Point, NY 10996 USA.
[Mayhew, Jerry L.] Truman State Univ, Kirksville, MO USA.
[Mayhew, Jerry L.] AT Still Univ Hlth Sci, Kirksville, MO USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2013
VL 45
IS 5
SU 1
MA 2451
BP 580
EP 580
PG 1
WC Sport Sciences
SC Sport Sciences
GA 300ND
UT WOS:000330469704343
ER
PT J
AU Clark, NJ
Mayhew, JL
Reneau, P
Brechue, WF
AF Clark, Nicole J.
Mayhew, Jerry L.
Reneau, Paul
Brechue, William F.
TI Effect Of Free-Weight And Machine-Weight Training On Upper-Body Strength
in Low- And High-Strength College Men
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
CT 60th Annual Meeting of the American-College-of-Sports-Medicine
CY MAY 28-JUN 01, 2013
CL Indianapolis, IN
SP Amer Coll Sports Med
C1 [Clark, Nicole J.; Mayhew, Jerry L.] Truman State Univ, Kirksville, MO USA.
[Reneau, Paul] Fairmont State Univ, Fairmont, WV USA.
[Brechue, William F.] US Mil Acad, West Point, NY 10996 USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2013
VL 45
IS 5
SU 1
MA 2488
BP 591
EP 591
PG 1
WC Sport Sciences
SC Sport Sciences
GA 300ND
UT WOS:000330469704380
ER
PT J
AU Reneau, P
Ryan, M
Brechue, WF
Pujol, TJ
Mann, JB
Mayhew, J
AF Reneau, Paul
Ryan, Michael
Brechue, William F.
Pujol, Thomas J.
Mann, J. B.
Mayhew, Jerry
TI Accuracy Of 1RM Bench Press Prediction Equations In Untrained, Trained,
And Athletic College-age Men
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
CT 60th Annual Meeting of the American-College-of-Sports-Medicine
CY MAY 28-JUN 01, 2013
CL Indianapolis, IN
SP Amer Coll Sports Med
C1 [Reneau, Paul; Ryan, Michael] Fairmont State Univ, Fairmont, WV USA.
[Brechue, William F.] US Mil Acad, West Point, NY 10996 USA.
[Pujol, Thomas J.] SE Missouri State Univ, Cape Girardeau, MO 63701 USA.
[Mann, J. B.] Univ Missouri, Columbia, MO USA.
[Mayhew, Jerry] Truman State Univ, Kirksville, MO USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2013
VL 45
IS 5
SU 1
MA 2535
BP 604
EP 605
PG 2
WC Sport Sciences
SC Sport Sciences
GA 300ND
UT WOS:000330469704427
ER
PT J
AU Wilken, JM
Shaffer, SW
Patzkowski, JC
Blanck, RV
Owens, JG
Hsu, JR
AF Wilken, Jason M.
Shaffer, Scott W.
Patzkowski, Jeanne C.
Blanck, Ryan V.
Owens, Johnny G.
Hsu, Joseph R.
TI Activity Limitations Following Severe Extremity Trauma in Military
Service Members
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
CT 60th Annual Meeting of the American-College-of-Sports-Medicine
CY MAY 28-JUN 01, 2013
CL Indianapolis, IN
SP Amer Coll Sports Med
C1 [Wilken, Jason M.; Blanck, Ryan V.; Owens, Johnny G.] Ctr Intrepid, Ft Sam Houston, TX USA.
[Shaffer, Scott W.] US Army Baylor Univ Doctoral Program Phys Therapy, Ft Sam Houston, TX USA.
[Patzkowski, Jeanne C.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA.
[Hsu, Joseph R.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2013
VL 45
IS 5
SU 1
MA 2556
BP 611
EP 611
PG 1
WC Sport Sciences
SC Sport Sciences
GA 300ND
UT WOS:000330469705007
ER
PT J
AU DiPasquale, DM
Strangman, GE
Muza, SR
AF DiPasquale, Dana M.
Strangman, Gary E.
Muza, Stephen R.
TI Altitude Vs. Hypoxia: Comparing The Effects Of Exercise In Hypobaric And
Normobaric Hypoxia On Resting Heart Rate
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
CT 60th Annual Meeting of the American-College-of-Sports-Medicine
CY MAY 28-JUN 01, 2013
CL Indianapolis, IN
SP Amer Coll Sports Med
C1 [DiPasquale, Dana M.; Strangman, Gary E.] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Cambridge, MA 02138 USA.
[Muza, Stephen R.] US Army Res Inst Environm Med, Natick, MA USA.
NR 0
TC 0
Z9 0
U1 2
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2013
VL 45
IS 5
SU 1
MA 2706
BP 632
EP 632
PG 1
WC Sport Sciences
SC Sport Sciences
GA 300ND
UT WOS:000330469705068
ER
PT J
AU Coffey, L
Roy, T
Lopez, H
AF Coffey, Laurel
Roy, Tanja
Lopez, Heather
TI Physical Demands and Low Back Pain in Deployed Soldiers
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
CT 60th Annual Meeting of the American-College-of-Sports-Medicine
CY MAY 28-JUN 01, 2013
CL Indianapolis, IN
SP Amer Coll Sports Med
C1 [Coffey, Laurel; Roy, Tanja] USARIEM, Natick, MA USA.
[Lopez, Heather] US Army, Ft Campbell, KY USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2013
VL 45
IS 5
SU 1
MA 2749
BP 646
EP 646
PG 1
WC Sport Sciences
SC Sport Sciences
GA 300ND
UT WOS:000330469705111
ER
PT J
AU Twenhafel, NA
Mattix, ME
Johnson, JC
Robinson, CG
Pratt, WD
Cashman, KA
Wahl-Jensen, V
Terry, C
Olinger, GG
Hensley, LE
Honko, AN
AF Twenhafel, N. A.
Mattix, M. E.
Johnson, J. C.
Robinson, C. G.
Pratt, W. D.
Cashman, K. A.
Wahl-Jensen, V.
Terry, C.
Olinger, G. G.
Hensley, L. E.
Honko, A. N.
TI Pathology of Experimental Aerosol Zaire Ebolavirus Infection in Rhesus
Macaques
SO VETERINARY PATHOLOGY
LA English
DT Article
DE aerosol; animal model; ebolavirus; filovirus; macaque; rhesus; Zaire;
Zaire ebolavirus
ID FIBROBLASTIC RETICULAR CELLS; HEMORRHAGIC-FEVER VIRUSES; AFRICAN-GREEN
MONKEYS; NIEMANN-PICK C1; DENDRITIC CELLS; NONHUMAN-PRIMATES; ALVEOLAR
MACROPHAGES; CYNOMOLGUS MACAQUES; MARBURG VIRUSES; NITRIC-OXIDE
AB There is limited knowledge of the pathogenesis of human ebolavirus infections and no reported human cases acquired by the aerosol route. There is a threat of ebolavirus as an aerosolized biological weapon, and this study evaluated the pathogenesis of aerosol infection in 18 rhesus macaques. Important and unique findings include early infection of the respiratory lymphoid tissues, early fibrin deposition in the splenic white pulp, and perivasculitis and vasculitis in superficial dermal blood vessels of haired skin with rash. Initial infection occurred in the respiratory lymphoid tissues, fibroblastic reticular cells, dendritic cells, alveolar macrophages, and blood monocytes. Virus spread to regional lymph nodes, where significant viral replication occurred. Virus secondarily infected many additional blood monocytes and spread from the respiratory tissues to multiple organs, including the liver and spleen. Viremia, increased temperature, lymphocytopenia, neutrophilia, thrombocytopenia, and increased alanine aminotransferase, aspartate aminotransferase, g-glutamyl transpeptidase, total bilirubin, serum urea nitrogen, creatinine, and hypoalbuminemia were measurable mid to late infection. Infection progressed rapidly with whole-body destruction of lymphoid tissues, hepatic necrosis, vasculitis, hemorrhage, and extravascular fibrin accumulation. Hypothermia and thrombocytopenia were noted in late stages with the development of disseminated intravascular coagulation and shock. This study provides unprecedented insight into pathogenesis of human aerosol Zaire ebolavirus infection and suggests development of a medical countermeasure to aerosol infection will be a great challenge due to massive early infection of respiratory lymphoid tissues. Rhesus macaques may be used as a model of aerosol infection that will allow the development of lifesaving medical countermeasures under the Food and Drug Administration's animal rule.
C1 [Twenhafel, N. A.; Mattix, M. E.; Johnson, J. C.; Robinson, C. G.; Pratt, W. D.; Cashman, K. A.; Terry, C.; Olinger, G. G.; Hensley, L. E.; Honko, A. N.] USAMRIID, Ft Detrick, MD USA.
[Wahl-Jensen, V.] NIAID, Integrated Res Facil Frederick, NIH, Frederick, MD USA.
RP Twenhafel, NA (reprint author), US Army, Med Res Inst Infect Dis, Div Pathol, 1425 Porter St, Ft Detrick, MD 21702 USA.
EM nancy.twenhafel@us.army.mil
OI Olinger, Gene/0000-0001-7338-0292; Johnson, Joshua/0000-0002-5677-3841;
Honko, Anna/0000-0001-9165-148X
NR 82
TC 30
Z9 31
U1 0
U2 12
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0300-9858
EI 1544-2217
J9 VET PATHOL
JI Vet. Pathol.
PD MAY
PY 2013
VL 50
IS 3
BP 514
EP 529
DI 10.1177/0300985812469636
PG 16
WC Pathology; Veterinary Sciences
SC Pathology; Veterinary Sciences
GA 298BJ
UT WOS:000330298600021
PM 23262834
ER
PT J
AU Agazio, J
Hillier, SL
Throop, M
Goodman, P
Padden, D
Greiner, S
Turner, A
AF Agazio, Janice
Hillier, Shannon L.
Throop, Meryia
Goodman, Petra
Padden, Diane
Greiner, Shawna
Turner, Annette
TI Mothers going to war: The role of nurse practitioners in the care of
military mothers and families during deployment
SO JOURNAL OF THE AMERICAN ASSOCIATION OF NURSE PRACTITIONERS
LA English
DT Article
DE Military; women; deployment; children; qualitative research; grounded
theory
ID MENSTRUAL SUPPRESSION
AB Purpose: Many military women are being called to separate from their children to go to war. Most previous research has focused upon paternal, rather than, maternal, separation. The purpose of this article is to describe the experience of military mothers and their children during wartime deployments with clinical implications for nurse practitioners (NPs) in military or community settings.
Data sources: Using grounded theory methods, 37 active duty and reserve component military women participated in a one-time interview. Included were women who deployed for at least 4 months to Iraq or Afghanistan and had at least one child under the age of 12 during the separation.
Conclusions: Military families present unique challenges for NPs. Mother deployments offer opportunities for intervention and anticipatory guidance across the trajectory of the separation. Military women's emotional and physical health must be supported before, during, and following deployment.
Implications for practice: NPs are ideally positioned to support military families. During deployment, the NP's focus may shift to care of the children and their caregiver. Before and at reintegration, NPs are in a key position to intervene early for posttraumatic stress and support family readjustment.
C1 [Agazio, Janice; Turner, Annette] Catholic Univ Amer, Sch Nursing, Washington, DC 20064 USA.
[Hillier, Shannon L.] Walter Reed Natl Mil Med Ctr, Dept Psychiat, Bethesda, MD USA.
[Throop, Meryia] Walter Reed Natl Mil Med Ctr, Ctr Nursing Sci & Clin Inquiry, Bethesda, MD USA.
[Goodman, Petra] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
[Padden, Diane; Greiner, Shawna] Uniformed Serv Univ Hlth Sci, Grad Sch Nursing, Bethesda, MD 20814 USA.
RP Agazio, J (reprint author), Catholic Univ Amer, Sch Nursing, 620 Michigan Ave NE, Washington, DC 20064 USA.
EM Agazio@cua.edu
FU TriService Nursing Research Program, Uniformed Services University of
the Health Sciences
FX This research was sponsored by the TriService Nursing Research Program,
Uniformed Services University of the Health Sciences; however, the
information or content and conclusions do not necessarily represent the
official position or policy of, nor should any official endorsement be
inferred by, the TriService Nursing Research Program, Uniformed Services
University of the Health Sciences, the Department of Defense, or the U.
S. Government.
NR 10
TC 2
Z9 2
U1 0
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2327-6886
EI 2327-6924
J9 J AM ASSOC NURSE PRA
JI J. Am. Assoc. Nurs. Pract.
PD MAY
PY 2013
VL 25
IS 5
BP 253
EP 262
DI 10.1111/j.1745-7599.2012.00811.x
PG 10
WC Health Care Sciences & Services; Nursing
SC Health Care Sciences & Services; Nursing
GA 296GM
UT WOS:000330173200004
PM 24170567
ER
PT J
AU Jarvis, SK
Wiles, GC
Appleton, SN
D'Arrigo, RD
Lawson, DE
AF Jarvis, Stephanie K.
Wiles, Gregory C.
Appleton, Sarah N.
D'Arrigo, Rosanne D.
Lawson, Daniel E.
TI A Warming-Induced Biome Shift Detected in Tree Growth of Mountain
Hemlock [Tsuga mertensiana (Bong.) Carriere] along the Gulf of Alaska
SO ARCTIC ANTARCTIC AND ALPINE RESEARCH
LA English
DT Article
ID GLACIER BAY; SOUTHEAST ALASKA; YELLOW-CEDAR; VARIABILITY; HISTORY;
FORESTS
AB Recent observations of divergence between tree growth at high-latitude sites and temperature, as well as the decline of yellow cedar [Callitropsis nootkatensis (D. Don) Oerst. ex D.P. Little] in southeast Alaska due to warming, emphasize a need to investigate nonstationary climate response of Alaskan coastal forests to warming in other tree species. Comparison of annual tree growth in mountain hemlock [Tsuga mertensiana (Bong.) Carriere] to mean monthly temperature and precipitation data from Sitka, Alaska, from A.D. 1830s to 1990s along an elevational transect reveals nonstationarity in tree growth response to climate that suggests an ongoing biome shift. We observe a marked weakening in the positive relationship between annual growth and warmer growth season temperatures at low-elevation hemlock sites, and a concurrent increase in growth and sensitivity at higher elevations coupled with increased correlation between growth and April precipitation at all sites along our transects. As previously observed with yellow cedar, the mechanism of the hemlock biome shift may be due to an increased susceptibility of roots to damage from late frosts resulting from earlier seasonal loss of protective snowpack.
C1 [Jarvis, Stephanie K.; Wiles, Gregory C.; Appleton, Sarah N.] Coll Wooster, Dept Geol, Wooster, OH 44691 USA.
[D'Arrigo, Rosanne D.] Columbia Univ, Lamont Doherty Earth Observ, Tree Ring Lab, Palisades, NY 10964 USA.
[Lawson, Daniel E.] US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
RP Jarvis, SK (reprint author), So Illinois Univ, Dept Geol, 1259 Lincoln Dr, Carbondale, IL 62901 USA.
EM sjarvis@siu.edu
FU National Science Foundation [ATM-0902799, AGS-1202218]; National
Geographic Society
FX We thank Glacier Bay National Park and Preserve and the National Forest
Service (U.S. Forest Service Special Use Permit FS-2700-4) for allowing
us to sample the mountain hemlock and yellow-cedar trees for this study
and the National Park Service for logistical support. We also thank
Marilyn Loveless for the many ecology discussions pertaining to this
study and are grateful for the constructive feedback of two anonymous
reviewers. This work was supported by the National Science Foundation
(ATM-0902799 and AGS-1202218). Part of the Excursion Ridge chronology
sampling was made possible by a grant from the National Geographic
Society. Lamont-Doherty contribution #7652.
NR 37
TC 3
Z9 3
U1 4
U2 19
PU INST ARCTIC ALPINE RES
PI BOULDER
PA UNIV COLORADO, BOULDER, CO 80309 USA
SN 1523-0430
EI 1938-4246
J9 ARCT ANTARCT ALP RES
JI Arct. Antarct. Alp. Res.
PD MAY
PY 2013
VL 45
IS 2
BP 211
EP 218
DI 10.1657/1938-4246-45.2
PG 8
WC Environmental Sciences; Geography, Physical
SC Environmental Sciences & Ecology; Physical Geography
GA 287HQ
UT WOS:000329533100005
ER
PT J
AU Rodkvamtook, W
Gaywee, J
Kanjanavanit, S
Ruangareerate, T
Richards, AL
Sangjun, N
Jeamwattanalert, P
Sirisopana, N
AF Rodkvamtook, Wuttikon
Gaywee, Jariyanart
Kanjanavanit, Suparat
Ruangareerate, Toon
Richards, Allen L.
Sangjun, Noppadon
Jeamwattanalert, Pimmada
Sirisopana, Narongrid
TI Scrub Typhus Outbreak, Northern Thailand, 2006-2007
SO EMERGING INFECTIOUS DISEASES
LA English
DT Article
ID ORIENTIA-TSUTSUGAMUSHI STRAINS; RICKETTSIA-TSUTSUGAMUSHI; TROMBICULID
MITES; FEEDING PROCESS; TRANSMISSION; MALAYSIA; GENES
AB During a scrub typhus outbreak investigation in Thailand, 4 isolates of O. tsutsugamushi were obtained and established in culture. Phylogenetic analysis based on the 56-kDa type-specific antigen gene demonstrated that the isolates fell into 4 genetic clusters, 3 of which had been previously reported and 1 that represents a new genotype.
C1 [Rodkvamtook, Wuttikon] Armed Forces Res Inst Med Sci, Pathol Sect, Div Res, Royal Thai Army Component, Bangkok 10400, Thailand.
[Gaywee, Jariyanart; Ruangareerate, Toon; Sangjun, Noppadon; Jeamwattanalert, Pimmada; Sirisopana, Narongrid] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Kanjanavanit, Suparat] Nakhornping Hosp, Chiang Mai, Thailand.
[Richards, Allen L.] Naval Med Res Ctr, Silver Spring, MD USA.
RP Gaywee, J (reprint author), Armed Forces Res Inst Med Sci, Royal Thai Amy, Bangkok 10400, Thailand.
EM jariyanartg@afrims.org
FU Royal Thai Army; Thailand Tropical Diseases Research Funding Program
[T-2]; Thanphuying Viraya Chavakul Foundation for Medical Armed Forces
Research Grant; Global Emerging Infections Surveillance and Response
System, a Division of the Armed Forces Health Surveillance Center
[0000188M.0931.001.A0074]
FX Support for this study was provided by the Royal Thai Army (to W.R.);
the Thailand Tropical Diseases Research Funding Program (T-2; to J.G.);
the Thanphuying Viraya Chavakul Foundation for Medical Armed Forces
Research Grant (to T.R.); and the Global Emerging Infections
Surveillance and Response System, a Division of the Armed Forces Health
Surveillance Center (work unit no. 0000188M.0931.001.A0074) (to A.L.R.).
NR 15
TC 7
Z9 9
U1 3
U2 7
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
EI 1080-6059
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD MAY
PY 2013
VL 19
IS 5
BP 774
EP 777
DI 10.3201/eid1905.121445
PG 4
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 268LX
UT WOS:000328173400012
PM 23647883
ER
PT J
AU Song, MC
Sankar, BV
Subhash, G
Yen, CF
AF Song, M. C.
Sankar, B. V.
Subhash, G.
Yen, C. F.
TI Finite Element Analysis of Delamination in Woven Composites under
Quasi-Static Indentation
SO CMC-COMPUTERS MATERIALS & CONTINUA
LA English
DT Article
DE 3D woven composites; plain woven laminate; FEM cohesive element;
delamination
ID NUMERICAL-SIMULATION; DAMAGE; TOUGHNESS; FRACTURE; PROPAGATION; CRACKS;
BEAMS; MODEL; PINS
AB Delamination initiation and propagation in plain woven laminates and 3D orthogonal woven composites during short beam shear (SBS) test were analyzed using finite element (FE) analyses. Two kinds of 3D woven composites, containing single z-yarns and double z-yarns, were considered. The FE models were guided by experimental observations from SBS tests for the same material systems. A series of mechanisms including creation and evolution of matrix cracks and delaminations were modeled discretely. The force-displacement curves obtained from the FE simulations were compared with those from experiments. Further parametric studies were conducted to investigate the effects of z-yams and interlaminar fracture toughness on delamination in woven composites. The results from the FE simulations revealed that z-yarns in 3D woven composites can play a major role in impeding propagation of interlaminar cracks. On the other hand 2D plain woven laminates without any z-reinforcement demonstrated higher interlaminar fracture toughness due to undulation in yams. 3D woven composites with double yams showed better damage tolerance than single yarn 3D woven composites and their behavior was very similar to composite laminates with high interlaminar fracture toughness.
C1 [Song, M. C.; Sankar, B. V.; Subhash, G.] Univ Florida, Gainesville, FL 32610 USA.
[Yen, C. F.] US Army Res Lab, Aberdeen Proving Ground, MD USA.
RP Song, MC (reprint author), Univ Florida, Gainesville, FL 32610 USA.
FU United States Army Research Office [W911NF-08-1-0120]; United States
Army Research Laboratory
FX The funding for this work was provided by the United States Army
Research Office (grant number W911NF-08-1-0120) and the United States
Army Research Laboratory. The authors also would liketo thank Dr. Bazle
Z. (Gama) Hague at the University of Delaware for the personal
communication about the volume fraction of yarns in 3D woven composites.
NR 33
TC 0
Z9 0
U1 0
U2 6
PU TECH SCIENCE PRESS
PI NORCROSS
PA 6825 JIMMY CARTER BLVD, STE 1850, NORCROSS, GA 30071 USA
SN 1546-2218
EI 1546-2226
J9 CMC-COMPUT MATER CON
JI CMC-Comput. Mat. Contin.
PD MAY
PY 2013
VL 35
IS 1
BP 67
EP 85
PG 19
WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary;
Mathematics, Interdisciplinary Applications
SC Engineering; Materials Science; Mathematics
GA 255GG
UT WOS:000327226800005
ER
PT J
AU Carlucci, DE
Frydman, AM
Cordes, JA
AF Carlucci, D. E.
Frydman, A. M.
Cordes, J. A.
TI Mathematical Description of Projectile Shot Exit Dynamics (Set-Forward)
SO JOURNAL OF APPLIED MECHANICS-TRANSACTIONS OF THE ASME
LA English
DT Article; Proceedings Paper
CT 27th International Symposium on Ballistics (ISB)
CY APR 22-26, 2013
CL Freiburg, GERMANY
SP Fraunhofer Inst High Speed Dynam, Ernst Mach Inst, Natl Def Ind Assoc
DE muzzle exit; gun launch; dynamics; mathematics; ringing; set-forward;
accelerometers
AB The dynamics or "ringing" of a projectile structure at gun-muzzle exit has been observed to cause a large number of electronics failures in projectiles as well as possible safety concerns with respect to components impacting one another or structural components of the projectile coming apart. Current numerical tools allow accurate calculation of the muzzle exit event given that the engineer understands the forces acting on the projectile. Dynamic response of a structure is well understood by persons working in the field; however, engineers who do not regularly deal with dynamic analyses generally have difficulty interpreting results from both analyses and tests. This paper details the mathematics associated with this event so that the engineer confronted with a dynamics related issue can have a reference for understanding and interpretation. The results of a simple model show that accelerometer data should be used with caution and the support of a finite element analysis of the projectile structure with the proper pressure decay is usually necessary. Recommendations for use of measured acceleration data for modeling and simulation are provided.
C1 [Carlucci, D. E.; Cordes, J. A.] US Army ARDEC RDAR DSM, Picatinny Arsenal, NJ 07806 USA.
[Frydman, A. M.] Army Res Lab, Adelphi, MD 20783 USA.
RP Carlucci, DE (reprint author), US Army ARDEC RDAR DSM, Bldg 94,2nd Floor, Picatinny Arsenal, NJ 07806 USA.
NR 19
TC 1
Z9 1
U1 0
U2 2
PU ASME
PI NEW YORK
PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA
SN 0021-8936
EI 1528-9036
J9 J APPL MECH-T ASME
JI J. Appl. Mech.-Trans. ASME
PD MAY
PY 2013
VL 80
IS 3
SI SI
AR 031501
DI 10.1115/1.4023335
PG 9
WC Mechanics
SC Mechanics
GA 241OI
UT WOS:000326176200010
ER
PT J
AU Manning, TG
Leone, J
Zebregs, M
Ramlal, DR
van Driel, CA
AF Manning, Thelma G.
Leone, Joseph
Zebregs, Martijn
Ramlal, Dinesh R.
van Driel, Chris A.
TI Definition of a JA-2 Equivalent Propellant to be Produced by Continuous
Solventless Extrusion
SO JOURNAL OF APPLIED MECHANICS-TRANSACTIONS OF THE ASME
LA English
DT Article; Proceedings Paper
CT 27th International Symposium on Ballistics (ISB)
CY APR 22-26, 2013
CL Freiburg, GERMANY
SP Fraunhofer Inst High Speed Dynam, Ernst Mach Inst, Natl Def Ind Assoc
AB In order to eliminate residual solvents in ammunition and to reduce the emissions of volatile organic compounds to the atmosphere, the U. S. Army ARDEC has teamed with TNO in developing a new process for the production of solventless propellant for tank ammunition. To reduce the costs of solventless propellants production, shear roll mill and continuous extrusion processing was investigated. As described in this paper JA-2 a double base propellant cannot be processed without solvent by the extrusion process. An alternative JA-2 equivalent propellant was defined. The aim of this work is to demonstrate the manufacturing of this propellant by solventless continuous twin screw extrusion processing while maintaining gun performance characteristics of conventional JA-2 propellant. This is elucidated by explicitly researching the relationship between interior ballistic properties of the gun propellant and utilizing a continuous manufacturing process. Processing conditions were established, and the propellant was manufactured accordingly. The extruded propellant has the desired properties, which resulted in a comparable gun performance as the conventional JA-2 propellant.
C1 [Manning, Thelma G.; Leone, Joseph] US Army RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA.
[Zebregs, Martijn; Ramlal, Dinesh R.; van Driel, Chris A.] TNO, NL-2288 GJ Rijswijk, Netherlands.
RP Manning, TG (reprint author), US Army RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA.
EM thelma.g.manning.civ@mail.mil; martijn.zebregs@tno.nl
NR 10
TC 1
Z9 1
U1 0
U2 5
PU ASME
PI NEW YORK
PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA
SN 0021-8936
EI 1528-9036
J9 J APPL MECH-T ASME
JI J. Appl. Mech.-Trans. ASME
PD MAY
PY 2013
VL 80
IS 3
SI SI
AR 031405
DI 10.1115/1.4023315
PG 7
WC Mechanics
SC Mechanics
GA 241OI
UT WOS:000326176200006
ER
PT J
AU Strassburger, E
Hunzinger, M
Patel, P
McCauley, JW
AF Strassburger, Elmar
Hunzinger, Martin
Patel, Parimal
McCauley, James W.
TI Analysis of the Fragmentation of AlON and Spinel Under Ballistic Impact
SO JOURNAL OF APPLIED MECHANICS-TRANSACTIONS OF THE ASME
LA English
DT Article; Proceedings Paper
CT 27th International Symposium on Ballistics (ISB)
CY APR 22-26, 2013
CL Freiburg, GERMANY
SP Fraunhofer Inst High Speed Dynam, Ernst Mach Inst, Natl Def Ind Assoc
DE fragmentation; ceramic; AlON; magnesium aluminate spinel; high-speed
photography; laser light-sheet technique
ID TRANSPARENT ARMOR; PROPAGATION; CERAMICS; FRACTURE; FAILURE; CRACKS;
GLASS
AB It has been demonstrated that significant weight reductions can be achieved, compared to conventional glass-based armor, when a transparent ceramic is used as the strike face on a glass-polymer laminate. Magnesium aluminate spinel (MgAl2O4) and AlON are promising candidate materials for application as a hard front layer in transparent armor. Comprehensive, systematic investigations of the fragmentation of ceramics have shown that the mode of fragmentation is one of the key parameters influencing the ballistic resistance of ceramics. In the study described here, the fragmentation of AlON and three types of spinel was analyzed: two types of fine grained spinel with nominal average grain sizes 0.6 mu m and 1.6 mu m and a bimodal grain-sized spinel with large grains of 250 mu m size in a fine grain (5-20 mu m) matrix were examined. The ceramic specimens of 6-mm thickness were glued to an aluminum backing and impacted with armor piercing (AP) projectiles of caliber 7.62 mm at two different velocities-850 m/s and 1100 m/s. The targets were integrated into a target box, which allowed for an almost complete recovery and analysis of the ceramic fragments. Different types of high-speed cameras were applied in order to visualize the different phases of fragment formation and ejection. A laser light-sheet illumination technique was applied in combination with high-speed cameras in order to determine size and speed of ejected ceramic fragments during projectile penetration. The application of the visualization techniques allowed for the analysis of the dynamics of the fragment formation and interaction with the projectile. A significant difference in the fragment size distributions of bimodal grain-sized spinel and AlON was observed.
C1 [Strassburger, Elmar; Hunzinger, Martin] Ernst Mach Inst, Fraunhofer Inst High Speed Dynam, D-79400 Kandern, Germany.
[Patel, Parimal; McCauley, James W.] US Army Res Lab, AMSRD ARL WM MD, Aberdeen Proving Ground, MD 21005 USA.
RP Strassburger, E (reprint author), Ernst Mach Inst, Fraunhofer Inst High Speed Dynam, Christianswuhr 2, D-79400 Kandern, Germany.
EM elmar.strassburger@emi.fraunhofer.de
NR 19
TC 2
Z9 2
U1 3
U2 32
PU ASME
PI NEW YORK
PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA
SN 0021-8936
EI 1528-9036
J9 J APPL MECH-T ASME
JI J. Appl. Mech.-Trans. ASME
PD MAY
PY 2013
VL 80
IS 3
SI SI
AR 031807
DI 10.1115/1.4023573
PG 11
WC Mechanics
SC Mechanics
GA 241OI
UT WOS:000326176200025
ER
PT J
AU Kondle, S
Alvarado, JL
Marsh, C
AF Kondle, Satyanarayana
Alvarado, Jorge L.
Marsh, Charles
TI Laminar Flow Forced Convection Heat Transfer Behavior of a Phase Change
Material Fluid in Microchannels
SO JOURNAL OF HEAT TRANSFER-TRANSACTIONS OF THE ASME
LA English
DT Article
DE phase change material fluid; microchannel; convective heat transfer;
constant heat flux; constant wall temperature; effective specific heat
ID CHANGE MATERIAL SLURRIES; CIRCULAR TUBE; RECTANGULAR MICROCHANNELS;
SINK; PERFORMANCE; SUSPENSION; WATER
AB In this paper, a phase change material (PCM) fluid (N-eicosane) is compared with pure water as heat transfer fluid. The heat transfer behavior of PCM fluid under laminar flow conditions (Reynolds number of 700) in circular and rectangular microchannels was studied numerically. In the numerical study, an effective specific heat model was used to take into account the phase change process. Heat transfer results for circular and rectangular microchannels with PCM fluid were obtained under hydrodynamically and thermally fully developed conditions. A PCM fluid in microchannels with aspect ratios of 1 to 2, 1 to 4, and 1 to 8 was found to enhance the thermal behavior of microchannels which can be beneficial in a host of cooling applications. The flow was assumed to be hydrodynamically fully developed at the inlet and thermally developing inside the microchannel. Heat transfer characteristics of PCM slurry flow in microchannels have been studied under three types of wall boundary conditions including constant axial heat flux with constant peripheral temperature (H1), constant heat flux with variable peripheral temperature (H2), and constant wall temperature (T) boundary condition. The fully developed Nusselt number was found to be higher for H1 than for H2 and T boundary conditions for all the geometries. Moreover, Nusselt number also increased with aspect ratio and was sensitive to the variations in effective specific heat.
C1 [Kondle, Satyanarayana] Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA.
[Alvarado, Jorge L.] Texas A&M Univ, Dept Engn Technol & Ind Distribut, College Stn, TX 77843 USA.
[Marsh, Charles] US Army Corps Engineers, Engineer & Res Dev Ctr, Champaign, IL 61822 USA.
RP Alvarado, JL (reprint author), Texas A&M Univ, Dept Engn Technol & Ind Distribut, College Stn, TX 77843 USA.
EM alvarado@entc.tamu.edu
OI Alvarado, Jorge/0000-0002-4059-6588
NR 27
TC 4
Z9 4
U1 0
U2 18
PU ASME
PI NEW YORK
PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA
SN 0022-1481
EI 1528-8943
J9 J HEAT TRANS-T ASME
JI J. Heat Transf.-Trans. ASME
PD MAY
PY 2013
VL 135
IS 5
AR 052801
DI 10.1115/1.4023221
PG 11
WC Thermodynamics; Engineering, Mechanical
SC Thermodynamics; Engineering
GA 241JW
UT WOS:000326164000010
ER
PT J
AU Fortenberry, AD
AF Fortenberry, Andrew D.
TI Comminuted Fractures of the Femoral Neck and Scaphoid
SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
LA English
DT Editorial Material
C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
RP Fortenberry, AD (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
NR 1
TC 0
Z9 0
U1 0
U2 1
PU J O S P T,
PI ALEXANDRIA
PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA
SN 0190-6011
J9 J ORTHOP SPORT PHYS
JI J. Orthop. Sports Phys. Ther.
PD MAY
PY 2013
VL 43
IS 5
BP 350
EP 350
DI 10.2519/jospt.2013.0409
PG 1
WC Orthopedics; Rehabilitation; Sport Sciences
SC Orthopedics; Rehabilitation; Sport Sciences
GA 236FV
UT WOS:000325781800009
PM 23636181
ER
PT J
AU Ling, J
Yapa, SD
Benson, MJ
Elkins, CJ
Eaton, JK
AF Ling, Julia
Yapa, Sayuri D.
Benson, Michael J.
Elkins, Christopher J.
Eaton, John K.
TI Three-Dimensional Velocity and Scalar Field Measurements of an Airfoil
Trailing Edge With Slot Film Cooling: The Effect of an Internal
Structure in the Slot
SO JOURNAL OF TURBOMACHINERY-TRANSACTIONS OF THE ASME
LA English
DT Article
ID GAS-TURBINE AIRFOILS; CUTBACK; FLOWS
AB Measurements of the 3D velocity and concentration fields were obtained using magnetic resonance imaging for a pressure-side cutback film cooling experiment. The cutback geometry consisted of rectangular slots separated by straight lands; inside each of the slots was an airfoil-shaped blockage. The results from this trailing edge configuration, the "island airfoil," are compared to the results obtained with the " generic airfoil," a geometry with narrower slots, wider, tapered lands, and no blockages. The objective was to determine how the narrower lands and internal blockages affected the average film cooling effectiveness and the spanwise uniformity. Velocimetry data revealed that strong horseshoe vortices formed around the blockages in the slots, which resulted in greater coolant nonuniformity on the airfoil breakout surface and in the wake. The thinner lands of the island airfoil allowed the coolant to cover a larger fraction of the trailing edge span, giving a much higher spanwise-averaged surface effectiveness, especially near the slot exit where the generic airfoil lands are widest.
C1 [Ling, Julia; Yapa, Sayuri D.; Elkins, Christopher J.; Eaton, John K.] Stanford Univ, Stanford, CA 94305 USA.
[Benson, Michael J.] US Mil Acad, West Point, NY 10996 USA.
RP Ling, J (reprint author), Stanford Univ, Stanford, CA 94305 USA.
EM julial@stanford.edu
FU National Science Foundation
FX This work was supported by members of the Stanford Thermal and Fluid
Sciences Affiliates Program. J. Ling was supported by a National Science
Foundation Graduate Fellowship.
NR 20
TC 10
Z9 10
U1 1
U2 7
PU ASME
PI NEW YORK
PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA
SN 0889-504X
EI 1528-8900
J9 J TURBOMACH
JI J. Turbomach.-Trans. ASME
PD MAY
PY 2013
VL 135
IS 3
AR 031018
DI 10.1115/1.4007520
PG 8
WC Engineering, Mechanical
SC Engineering
GA 239KD
UT WOS:000326021300018
ER
PT J
AU Klein, DJ
Venkateswaran, S
Isaacs, JT
Burman, J
Pham, T
Hespanha, J
Madhow, U
AF Klein, Daniel J.
Venkateswaran, Sriram
Isaacs, Jason T.
Burman, Jerry
Pham, Tien
Hespanha, Joao
Madhow, Upamanyu
TI Localization with Sparse Acoustic Sensor Network Using UAVs as
Information-Seeking Data Mules
SO ACM TRANSACTIONS ON SENSOR NETWORKS
LA English
DT Article
DE Algorithms; Performance; Routing; acoustic source localization; large
scale; heterogeneous; time of arrival; angle of arrival; UAV routing
ID OPTIMIZATION
AB We propose and demonstrate a novel architecture for on-the-fly inference while collecting data from sparse sensor networks. In particular, we consider source localization using acoustic sensors dispersed over a large area, with the individual sensors located too far apart for direct connectivity. An Unmanned Aerial Vehicle (UAV) is employed for collecting sensor data, with the UAV route adaptively adjusted based on data from sensors already visited, in order to minimize the time to localize events of interest. The UAV therefore acts as a information-seeking data mule, not only providing connectivity, but also making Bayesian inferences from the data gathered in order to guide its future actions. The system we demonstrate has a modular architecture, comprising efficient algorithms for acoustic signal processing, routing the UAV to the sensors, and source localization. We report on extensive field tests which not only demonstrate the effectiveness of our general approach, but also yield specific practical insights into GPS time synchronization and localization accuracy, acoustic signal and channel characteristics, and the effects of environmental phenomena.
C1 [Klein, Daniel J.; Venkateswaran, Sriram; Isaacs, Jason T.; Hespanha, Joao; Madhow, Upamanyu] Univ Calif Santa Barbara, ECE Dept, Santa Barbara, CA 93106 USA.
[Burman, Jerry] Teledyne Sci Co, Thousand Oaks, CA 91360 USA.
[Pham, Tien] US Army Res Lab, Adelphi, MD 20783 USA.
RP Klein, DJ (reprint author), Univ Calif Santa Barbara, ECE Dept, Santa Barbara, CA 93106 USA.
EM djklein@gmail.com
RI Hespanha, Joao/C-2569-2008
OI Hespanha, Joao/0000-0003-2809-4718
FU Institute for Collaborative Biotechnologies from the U.S. Army Research
Office [W911NF-09-0001]
FX The work was supported by the Institute for Collaborative
Biotechnologies through grant W911NF-09-0001 from the U.S. Army Research
Office. The content of the information does not necessarily reflect the
position or the policy of the Government, and no official endorsement
should be inferred.
NR 41
TC 3
Z9 3
U1 0
U2 11
PU ASSOC COMPUTING MACHINERY
PI NEW YORK
PA 2 PENN PLAZA, STE 701, NEW YORK, NY 10121-0701 USA
SN 1550-4859
J9 ACM T SENSOR NETWORK
JI ACM Trans. Sens. Netw.
PD MAY
PY 2013
VL 9
IS 3
AR 30
DI 10.1145/2480730.2480733
PG 29
WC Computer Science, Information Systems; Telecommunications
SC Computer Science; Telecommunications
GA 208UG
UT WOS:000323705400003
ER
PT J
AU Byron, MM
Valcour, V
Ananworanich, J
Agsalda, M
Chalermchai, T
Tipsuk, S
Sithinamsuwan, P
Schuetz, A
Hutchings, N
Barbour, J
Phanuphak, N
Shikuma, C
Shiramizu, B
Ndhlovu, L
AF Byron, Mary Margaret
Valcour, Victor
Ananworanich, Jintanat
Agsalda, Melissa
Chalermchai, Thep
Tipsuk, Somporn
Sithinamsuwan, Pasiri
Schuetz, Alexandra
Hutchings, Nicholas
Barbour, Jason
Phanuphak, Nittaya
Shikuma, Cecilia
Shiramizu, Bruce
Ndhlovu, Lishomwa
TI CD16+expressing monocyte subsets and CD14+HIV DNA levels predict
HIV-associated neurocognitive disorders (HAND) in treatment-naive HIV
infected Thai subjects
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
CT 100th Annual Meeting of the American-Association-of-Immunologists
CY MAY 03-07, 2013
CL Honolulu, HI
SP Amer Assoc Immunologists
C1 [Byron, Mary Margaret; Agsalda, Melissa; Barbour, Jason; Phanuphak, Nittaya; Shikuma, Cecilia; Shiramizu, Bruce; Ndhlovu, Lishomwa] Univ Hawaii Manoa, Honolulu, HI 96822 USA.
[Valcour, Victor; Hutchings, Nicholas] Univ Calif San Francisco, San Francisco, CA 94143 USA.
[Ananworanich, Jintanat; Chalermchai, Thep; Tipsuk, Somporn; Phanuphak, Nittaya] Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand.
[Ananworanich, Jintanat] Chulalongkorn Univ, Fac Med, Bangkok 10330, Thailand.
[Ananworanich, Jintanat] Thai Red Cross AIDS Res Ctr, HIV NAT, Bangkok, Thailand.
[Sithinamsuwan, Pasiri] Phramongkutklao Hosp, Bangkok, Thailand.
[Schuetz, Alexandra] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
J9 J IMMUNOL
JI J. Immunol.
PD MAY 1
PY 2013
VL 190
MA P3043
PG 1
WC Immunology
SC Immunology
GA 199ID
UT WOS:000322987102220
ER
PT J
AU Kim, A
Hartman, I
Poore, B
Boronina, T
Lanar, D
Krzych, U
Cole, R
Sadegh-Nasseri, S
AF Kim, Ae
Hartman, Isamu
Poore, Bradley
Boronina, Tatiana
Lanar, David
Krzych, Urszula
Cole, Robert
Sadegh-Nasseri, Scheherazade
TI Cooperative functions of MHC II, HLA-DM, and cathepsins enhance the
selection of immunodominant epitopes
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
CT 100th Annual Meeting of the American-Association-of-Immunologists
CY MAY 03-07, 2013
CL Honolulu, HI
SP Amer Assoc Immunologists
C1 [Kim, Ae; Poore, Bradley; Boronina, Tatiana; Cole, Robert; Sadegh-Nasseri, Scheherazade] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
[Hartman, Isamu] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA.
[Lanar, David; Krzych, Urszula] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
J9 J IMMUNOL
JI J. Immunol.
PD MAY 1
PY 2013
VL 190
MA 415
PG 1
WC Immunology
SC Immunology
GA 199ID
UT WOS:000322987106121
ER
PT J
AU Konduru, K
Shurtleff, A
Bavari, S
Kaplan, G
AF Konduru, Krishnamurthy
Shurtleff, Amy
Bavari, Sina
Kaplan, Gerardo
TI Evaluation of ebolavirus glycoprotein Fc fusion protein as a subunit
vaccine
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
CT 100th Annual Meeting of the American-Association-of-Immunologists
CY MAY 03-07, 2013
CL Honolulu, HI
SP Amer Assoc Immunologists
C1 [Konduru, Krishnamurthy; Kaplan, Gerardo] US FDA, Ctr Biol Evaluat & Res, Bethesda, MD USA.
[Shurtleff, Amy; Bavari, Sina] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 3
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
J9 J IMMUNOL
JI J. Immunol.
PD MAY 1
PY 2013
VL 190
MA P4417
PG 1
WC Immunology
SC Immunology
GA 199ID
UT WOS:000322987105231
ER
PT J
AU Lieberman, M
Lehrer, A
Humphreys, T
Johns, L
Wong, TA
Olinger, G
Dye, J
Carrion, R
Patterson, J
Marzi, A
Feldmann, H
AF Lieberman, Michael
Lehrer, Axel
Humphreys, Tom
Johns, Lisa
Wong, Teri-Ann
Olinger, Gene
Dye, John
Carrion, Ricardo
Patterson, Jean
Marzi, Andrea
Feldmann, Heinz
TI Recombinant Ebolavirus antigens from insect cells are potent immunogens
inducing cellular and humoral immunity in rodents and non-human primates
and provide protection against virus challenge
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
CT 100th Annual Meeting of the American-Association-of-Immunologists
CY MAY 03-07, 2013
CL Honolulu, HI
SP Amer Assoc Immunologists
C1 [Lieberman, Michael] Lieberman Consulting, Honolulu, HI USA.
[Lehrer, Axel; Johns, Lisa; Wong, Teri-Ann] PanThera Biopharma LLC, Aiea, HI USA.
[Humphreys, Tom] Univ Hawaii, Honolulu, HI 96822 USA.
[Olinger, Gene; Dye, John] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA.
[Carrion, Ricardo; Patterson, Jean] Texas Biomed Res Inst, San Antonio, TX USA.
[Marzi, Andrea; Feldmann, Heinz] NIAID, NIH, Hamilton, MT USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
J9 J IMMUNOL
JI J. Immunol.
PD MAY 1
PY 2013
VL 190
MA P4325
PG 1
WC Immunology
SC Immunology
GA 199ID
UT WOS:000322987105140
ER
PT J
AU Rao, M
Peachman, K
Jobe, O
Kuaban, A
Billings, E
Guao, G
Wieczorek, L
Polonis, V
Pinter, A
Kim, J
Michael, N
Alving, C
Rao, V
AF Rao, Mangala
Peachman, Kristina
Jobe, Ousman
Kuaban, Alice
Billings, Erik
Guao, Guofen
Wieczorek, Lindsay
Polonis, Victoria
Pinter, Abraham
Kim, Jerome
Michael, Nelson
Alving, Carl
Rao, Venigalla
TI Induction of linear and conformational V2-specific antibodies using
HIV-1 gp145 clade B envelope protein as the immunogen
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
CT 100th Annual Meeting of the American-Association-of-Immunologists
CY MAY 03-07, 2013
CL Honolulu, HI
SP Amer Assoc Immunologists
C1 [Rao, Mangala; Peachman, Kristina; Jobe, Ousman; Billings, Erik; Wieczorek, Lindsay; Polonis, Victoria; Kim, Jerome; Michael, Nelson; Alving, Carl] Walter Reed Army Inst Res, USMHRP, Silver Spring, MD USA.
[Kuaban, Alice; Guao, Guofen; Rao, Venigalla] Catholic Univ Amer, Washington, DC 20064 USA.
[Pinter, Abraham] Univ Med & Dent New Jersey, New Jersey Med Sch, Newark, NJ 07103 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
J9 J IMMUNOL
JI J. Immunol.
PD MAY 1
PY 2013
VL 190
MA 17915
PG 1
WC Immunology
SC Immunology
GA 199ID
UT WOS:000322987106067
ER
PT J
AU Zarling, S
Krzych, U
AF Zarling, Stasya
Krzych, Urszula
TI Increased apoptosis of intrahepatic central memory CD8 T cells in the
absence of IL-15 is attributed to the loss of long-lasting protection
against malaria infection
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
CT 100th Annual Meeting of the American-Association-of-Immunologists
CY MAY 03-07, 2013
CL Honolulu, HI
SP Amer Assoc Immunologists
C1 [Zarling, Stasya; Krzych, Urszula] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
J9 J IMMUNOL
JI J. Immunol.
PD MAY 1
PY 2013
VL 190
MA P3334
PG 1
WC Immunology
SC Immunology
GA 199ID
UT WOS:000322987104009
ER
PT J
AU Napier, BA
Burd, EM
Satola, SW
Cagle, SM
Ray, SM
McGann, P
Pohl, J
Lesho, EP
Weiss, DS
AF Napier, Brooke A.
Burd, Eileen M.
Satola, Sarah W.
Cagle, Stephanie M.
Ray, Susan M.
McGann, Patrick
Pohl, Jan
Lesho, Emil P.
Weiss, David S.
TI Clinical Use of Colistin Induces Cross-Resistance to Host Antimicrobials
in Acinetobacter baumannii
SO MBIO
LA English
DT Article
ID PEPTIDE; POLYMYXIN; LYSOZYME; PATHOGEN
AB The alarming rise in antibiotic resistance has led to an increase in patient mortality and health care costs. This problem is compounded by the absence of new antibiotics close to regulatory approval. Acinetobacter baumannii is a human pathogen that causes infections primarily in patients in intensive care units (ICUs) and is highly antibiotic resistant. Colistin is one of the last-line antibiotics for treating A. baumannii infections; however, colistin-resistant strains are becoming increasingly common. This cationic antibiotic attacks negatively charged bacterial membranes in a manner similar to that seen with cationic antimicrobials of the innate immune system. We therefore set out to determine if the increasing use of colistin, and emergence of colistin-resistant strains, is concomitant with the generation of cross-resistance to host cationic antimicrobials. We found that there is indeed a positive correlation between resistance to colistin and resistance to the host antimicrobials LL-37 and lysozyme among clinical isolates. Importantly, isolates obtained before and after treatment of individual patients demonstrated that colistin use correlated with increased resistance to cationic host antimicrobials. These data reveal the overlooked risk of inducing cross-resistance to host antimicrobials when treating patients with colistin as a last-line antibiotic.
IMPORTANCE Increased use of the cationic antibiotic colistin to treat multidrug-resistant Acinetobacter baumannii has led to the development of colistin-resistant strains. Here we report that treatment of patients with colistin can induce not only increased resistance to colistin but also resistance to host cationic antimicrobials. This worrisome finding likely represents an example of a broader trend observed in other bacteria against which colistin is used therapeutically such as Pseudomonas aeruginosa and Klebsiella pneumoniae. Furthermore, these data suggest that the possible future use of an array of cationic antimicrobial peptides in development as therapeutics may have unintended negative consequences, eventually leading to the generation of hypervirulent strains that are resistant to innate host defenses. The potential for the induction of cross-resistance to innate immune antimicrobials should be considered during the development of new therapeutics.
C1 [Napier, Brooke A.; Weiss, David S.] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA.
[Napier, Brooke A.; Weiss, David S.] Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA.
[Burd, Eileen M.; Satola, Sarah W.; Cagle, Stephanie M.; Ray, Susan M.; Weiss, David S.] Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA 30322 USA.
[Satola, Sarah W.] Atlanta Vet Affairs Med Ctr, Atlanta, GA USA.
[Satola, Sarah W.; Cagle, Stephanie M.; Ray, Susan M.] Georgia Emerging Infect Program, Atlanta, GA USA.
[Burd, Eileen M.] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA.
[McGann, Patrick; Lesho, Emil P.] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD USA.
[Pohl, Jan] Ctr Dis Control & Prevent, Div Sci Resources, Biotechnol Core Facil Branch, Atlanta, GA USA.
[Ray, Susan M.] Grady Mem Hosp, Atlanta, GA USA.
RP Weiss, DS (reprint author), Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA.
EM david.weiss@emory.edu
RI Valle, Ruben/A-7512-2013
FU NIH [R21-AI098800]
FX This work was supported by NIH grant R21-AI098800. Its contents are
solely our responsibility and do not necessarily represent the official
views of the NIH.
NR 25
TC 15
Z9 15
U1 2
U2 16
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 2150-7511
J9 MBIO
JI mBio
PD MAY-JUN
PY 2013
VL 4
IS 3
AR e00021-13
DI 10.1128/mBio.00021-13
PG 5
WC Microbiology
SC Microbiology
GA 174WK
UT WOS:000321187400003
PM 23695834
ER
PT J
AU Arun, P
Abu-Taleb, R
Valiyaveettil, M
Wang, Y
Long, JB
Nambiar, MP
AF Arun, Peethambaran
Abu-Taleb, Rania
Valiyaveettil, Manojkumar
Wang, Ying
Long, Joseph B.
Nambiar, Madhusoodana P.
TI Extracellular cyclophilin A protects against blast-induced neuronal
injury
SO NEUROSCIENCE RESEARCH
LA English
DT Article
DE Traumatic brain injury; blast exposure; cyclophilin A; SH-SY5Y cells;
neuroprotection
ID TRAUMATIC BRAIN-INJURY; CORTICAL-NEURONS; PHOSPHORYLATION; SURVIVAL
AB Blast-induced traumatic brain injury (TBI) and subsequent neurobehavioral deficits are major disabilities suffered by the military and civilian population worldwide. Rigorous scientific research is underway to understand the mechanism of blast TBI and thereby develop effective therapies for protection and treatment. By using an in vitro shock tube model of blast TBI with SH-SY5Y human neuroblastoma cells, we have demonstrated that blast exposure leads to neurobiological changes in an overpressure and time dependent manner. Paradoxically, repeated blast exposures resulted in less neuronal injury compared to single blast exposure and suggested a potential neuroprotective mechanism involving released cyclophilin A (CPA). In the present study, we demonstrate accumulation of CPA in the culture medium after repeated blast exposures supporting the notion of extracellular CPA mediated neuroprotection. Post-exposure treatment of the cells with purified recombinant CPA caused significant protection against blast-induced neuronal injury. Furthermore, repeated blast exposure was associated with phosphorylation of the proteins ERK1/2 and Bad suggesting a potential mechanism of neuroprotection by extracellular CPA and may aid in the development of targeted therapies for protection against blast-induced TBI. (c) 2013 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
C1 [Arun, Peethambaran; Abu-Taleb, Rania; Valiyaveettil, Manojkumar; Wang, Ying; Long, Joseph B.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA.
RP Arun, P (reprint author), Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM peethambaran.arun@amedd.army.mil
NR 15
TC 2
Z9 2
U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0168-0102
J9 NEUROSCI RES
JI Neurosci. Res.
PD MAY-JUN
PY 2013
VL 76
IS 1-2
BP 98
EP 100
DI 10.1016/j.neures.2013.02.009
PG 3
WC Neurosciences
SC Neurosciences & Neurology
GA 179SH
UT WOS:000321541100013
PM 23511555
ER
PT J
AU Sadhu, B
Sturm, M
Sadler, BM
Harjani, R
AF Sadhu, Bodhisatwa
Sturm, Martin
Sadler, Brian M.
Harjani, Ramesh
TI Analysis and Design of a 5 GS/s Analog Charge-Domain FFT for an SDR
Front-End in 65 nm CMOS
SO IEEE JOURNAL OF SOLID-STATE CIRCUITS
LA English
DT Article; Proceedings Paper
CT IEEE Radio Frequency Integrated Circuits (RFIC) Symposium in Conjunction
with the IEEE MTT-S International Microwave Symposium (IMS) / Microwave
Week
CY JUN 17-19, 2012
CL Montreal, CANADA
SP IEEE, IEEE MTT S
DE Analytical models; analog integrated circuits; channel bank filters;
cognitive radio; demodulation; discrete cosine transforms; discrete
Fourier transforms; fast Fourier transforms; FET integrated circuits;
filtering; FIR filters; integrated circuit modeling; integrated circuit
noise; linear circuits; mixed analog digital integrated circuits;
modulation; MOS integrated circuits; multiplying circuits; multiple
signal classification; OFDM; passive circuits; passive filters; phase
shifters; radio-frequency integrated circuits; radio spectrum
management; RF signals; sampled data circuits; signal analysis; signal
detection; signal to noise ratio; software defined radio; software
radio; spectral analysis; signal sampling; summing circuits; switched
capacitor; switched circuits; transforms; very high speed integrated
circuits
ID SOFTWARE-DEFINED RADIO; RECEIVER; ARCHITECTURE
AB This work describes the design of a 16 point analog domain FFT using a Charge Re-use Analog Fourier Transform (CRAFT) engine. The circuit relies on charge re-use to achieve 47 dB average output SNDR on an instantaneous input bandwidth of 5 GHz, and consumes only 3.8 mW (12.2 pJ/conv.). The CRAFT engine is used as a wide-band, low power RF front-end channelizer for software defined radio (SDR) applications. The paper also discusses the handling of circuit non-idealities for the CRAFT design: their significance, modeling, and circuit techniques for their mitigation. These techniques enable this implementation to achieve a large dynamic range even at high speeds.
C1 [Sadhu, Bodhisatwa; Sturm, Martin; Harjani, Ramesh] Univ Minnesota, Minneapolis, MN 55455 USA.
[Sadler, Brian M.] Army Res Lab, Adelphi, MD 20783 USA.
RP Sadhu, B (reprint author), Univ Minnesota, Minneapolis, MN 55455 USA.
EM sadhu002@umn.edu
RI Sadhu, Bodhisatwa/K-7176-2014
OI Sadhu, Bodhisatwa/0000-0002-5849-9006
NR 28
TC 19
Z9 19
U1 0
U2 7
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-9200
EI 1558-173X
J9 IEEE J SOLID-ST CIRC
JI IEEE J. Solid-State Circuit
PD MAY
PY 2013
VL 48
IS 5
BP 1199
EP 1211
DI 10.1109/JSSC.2013.2250457
PG 13
WC Engineering, Electrical & Electronic
SC Engineering
GA 171NO
UT WOS:000320936300009
ER
PT J
AU Kuzhuget, AV
Beilina, L
Klibanov, MV
Sullivan, A
Nguyen, L
Fiddy, MA
AF Kuzhuget, Andrey V.
Beilina, Larisa
Klibanov, Michael V.
Sullivan, Anders
Lam Nguyen
Fiddy, Michael A.
TI Quantitative Image Recovery From Measured Blind Backscattered Data Using
a Globally Convergent Inverse Method
SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
LA English
DT Article
DE Experimental data; inverse scattering; quantitative imaging; remote
sensing
AB The goal of this paper is to introduce the application of a globally convergent inverse scattering algorithm to estimate dielectric constants of targets using time-resolved backscattering data collected by a U. S. Army Research Laboratory forward-looking radar. The processing of the data was conducted blind, i.e., without any prior knowledge of the targets. The problem is solved by formulating the scattering problem as a coefficient inverse problem for a hyperbolic partial differential equation. The main new feature of this algorithm is its rigorously established global convergence property. Calculated values of dielectric constants are in a good agreement with material properties, which were revealed a posteriori.
C1 [Kuzhuget, Andrey V.] Morgan Stanley, New York, NY 10036 USA.
[Beilina, Larisa] Chalmers, Dept Math Sci, S-42196 Gothenburg, Sweden.
[Beilina, Larisa] Gothenburg Univ, S-40530 Gothenburg, Sweden.
[Klibanov, Michael V.] Univ N Carolina, Dept Math & Stat, Charlotte, NC 28223 USA.
[Sullivan, Anders; Lam Nguyen] US Army Res Lab, Adelphi, MD 20783 USA.
[Fiddy, Michael A.] Univ N Carolina, Optoelect Ctr, Charlotte, NC 28223 USA.
RP Kuzhuget, AV (reprint author), Morgan Stanley, New York, NY 10036 USA.
EM larisa@chalmers.se; mklibanv@uncc.edu; anders.j.sullivan.civ@mail.mil;
lam.h.nguyen2.civ@mail.mil; mafiddy@uncc.edu
FU U. S. Army Research Laboratory; U.S. Army Research Office
[W911NF-11-1-0399]; Swedish Research Council (VR); Swedish Foundation
for Strategic Research (SSF) in Gothenburg Mathematical Modelling
Centre; Swedish Institute
FX Manuscript received March 24, 2012; revised July 22, 2012; accepted July
27, 2012. Date of publication September 21, 2012; date of current
version April 18, 2013. This work was supported in part by the U. S.
Army Research Laboratory and the U.S. Army Research Office under Grant
W911NF-11-1-0399; by the Swedish Research Council (VR); by the Swedish
Foundation for Strategic Research (SSF) in Gothenburg Mathematical
Modelling Centre; and by the Swedish Institute, Visby Program.
NR 21
TC 1
Z9 1
U1 0
U2 9
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0196-2892
J9 IEEE T GEOSCI REMOTE
JI IEEE Trans. Geosci. Remote Sensing
PD MAY
PY 2013
VL 51
IS 5
BP 2937
EP 2948
DI 10.1109/TGRS.2012.2211885
PN 2
PG 12
WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote
Sensing; Imaging Science & Photographic Technology
SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science
& Photographic Technology
GA 171OY
UT WOS:000320940000003
ER
PT J
AU Kumar, R
Curry, M
Ha, PK
Califano, J
Blanco, R
Richmon, J
AF Kumar, Rajesh
Curry, Martin
Ha, Patrick K.
Califano, Joseph
Blanco, Ray
Richmon, Jeremy
TI In Response To Objective Assessment in Residency-Based Training for
Transoral Robotic Surgery
SO LARYNGOSCOPE
LA English
DT Letter
C1 [Kumar, Rajesh] Johns Hopkins Univ, Dept Comp Sci, Baltimore, MD 21218 USA.
[Curry, Martin] US Army, San Antonio, TX USA.
[Ha, Patrick K.; Califano, Joseph] Johns Hopkins Med Inst, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21205 USA.
[Ha, Patrick K.; Califano, Joseph; Blanco, Ray] Johns Hopkins Head & Neck Surg, Milton J Dance Head & Neck Ctr, Greater Baltimore Med Ctr, Baltimore, MD USA.
[Richmon, Jeremy] Johns Hopkins Univ Hosp, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21287 USA.
RP Kumar, R (reprint author), Johns Hopkins Univ, Dept Comp Sci, Baltimore, MD 21218 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0023-852X
J9 LARYNGOSCOPE
JI Laryngoscope
PD MAY
PY 2013
VL 123
IS 5
BP 1317
EP 1317
DI 10.1002/lary.23960
PG 1
WC Medicine, Research & Experimental; Otorhinolaryngology
SC Research & Experimental Medicine; Otorhinolaryngology
GA 169LR
UT WOS:000320782200050
PM 23404291
ER
PT J
AU Hong, SK
Epureanu, BI
Castanier, MP
AF Hong, Sung-Kwon
Epureanu, Bogdan I.
Castanier, Matthew P.
TI Next-generation parametric reduced-order models
SO MECHANICAL SYSTEMS AND SIGNAL PROCESSING
LA English
DT Article
DE Parametric reduced order models; Thickness variation; Transformation
matrix; Parameterization techniques; Interface reduction
ID DYNAMIC ANALYSIS; DAMPED SYSTEMS; COMPONENT
AB Novel parametric reduced-order models are proposed for fast reanalysis to predict the dynamic response of complex structures, which suffered thickness variations caused by design changes or damage in one or more substructures. Parametric reduced-order models developed previously have two important challenges to overcome to improve accuracy and performance: (a) the transformation matrix is not mathematically stable and (b) the Taylor series parameterization techniques do not capture thickness variations of the structure modeled with solid-type elements due to the highly nonlinear dependence on thickness changes. Thus, herein, a new transformation matrix and novel parameterization techniques are proposed. Usual reduced-order models have an additional challenge, namely the difficulty in reducing the interface degrees of freedom. Thus a way of reducing the interface degrees of freedom is also proposed. The predicted vibration responses of complex structures are shown to agree very well with results obtained using a much more computationally expensive commercial tool. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Hong, Sung-Kwon; Epureanu, Bogdan I.] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA.
[Castanier, Matthew P.] US Army Tank Automot Res, Ctr Dev & Engn, Warren, MI 48397 USA.
RP Epureanu, BI (reprint author), Univ Michigan, Dept Mech Engn, 2350 Hayward St, Ann Arbor, MI 48109 USA.
EM sungkwon@umich.edu; epureanu@umich.edu; matt.castanier@us.army.mil
OI Castanier, Matthew/0000-0002-3646-382X
FU Automotive Research Center, a US Army Center of Excellence for Modeling
and Simulation of Ground Vehicles
FX The authors gratefully acknowledge the financial support of the
Automotive Research Center, a US Army Center of Excellence for Modeling
and Simulation of Ground Vehicles led by the University of Michigan.
NR 27
TC 7
Z9 7
U1 1
U2 13
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0888-3270
J9 MECH SYST SIGNAL PR
JI Mech. Syst. Signal Proc.
PD MAY-JUN
PY 2013
VL 37
IS 1-2
SI SI
BP 403
EP 421
DI 10.1016/j.ymssp.2012.12.012
PG 19
WC Engineering, Mechanical
SC Engineering
GA 148GJ
UT WOS:000319232200028
ER
PT J
AU Guo, Q
Dasgupta, D
Doll, TAPF
Burkhard, P
Lanar, DE
AF Guo, Qin
Dasgupta, Debleena
Doll, Tais A. P. F.
Burkhard, Peter
Lanar, David E.
TI Expression, purification and refolding of a self-assembling protein
nanoparticle (SAPN) malaria vaccine
SO METHODS
LA English
DT Article
DE Malaria; Nanoparticles; Vaccine; P. falciparum; Circumsporozoite protein
ID PEPTIDE NANOPARTICLES; DISPLAY; DESIGN; SERVE
AB There are many ways to present antigens to the immune system. We have used a repetitive antigen display technology that relies on the self-assembly of 60 protein chains into a spherical self-assembling protein nanoparticle (SAPN) to develop a vaccine against Plasmodium falciparum malaria. The protein sequence contains selected B- and T-cell epitopes of the circumsporozoite protein of P. falciparum (PfCSP) and, when assembled into a nanoparticle induces strong, long-lived and protective immune responses against the PfCSP. Here we describe the conditions needed for promoting self-assembly of a P. falciparum vaccine nanoparticle, PfCSP-KMY-SAPN, and note pitfalls that may occur when determining conditions for other SAPN vaccines. Attention was paid to selecting processes that were amenable to scale up and cGMP manufacturing. Published by Elsevier Inc.
C1 [Guo, Qin; Dasgupta, Debleena; Lanar, David E.] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD 20910 USA.
[Doll, Tais A. P. F.; Burkhard, Peter] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA.
[Burkhard, Peter] Univ Connecticut, Dept Mol & Cell Biol, Storrs, CT 06269 USA.
RP Lanar, DE (reprint author), Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD 20910 USA.
EM david.e.lanar.civ@mail.mil
FU Military Infectious Disease Research Program (MIDRP); NIH Grant
[1R01AI068761]
FX Material has been reviewed by the Walter Reed Army Institute of
Research. There is no objection to its presentation and/or publication.
The opinions or assertions contained herein are the private views of the
authors, and are not to be construed as official, or as reflecting true
views of the Department of the Army or the Department of Defense. Work
was funded by the Military Infectious Disease Research Program (MIDRP)
and the NIH Grant 1R01AI068761. PB has an interest in the company
Alpha-O Peptides that has patents or patents pending on the technology.
NR 7
TC 5
Z9 6
U1 3
U2 12
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1046-2023
J9 METHODS
JI Methods
PD MAY 1
PY 2013
VL 60
IS 3
BP 242
EP 247
DI 10.1016/j.ymeth.2013.03.025
PG 6
WC Biochemical Research Methods; Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 173QE
UT WOS:000321093200004
PM 23548672
ER
PT J
AU Miranda, LE
Killgore, KJ
Hoover, JJ
AF Miranda, L. E.
Killgore, K. J.
Hoover, J. J.
TI Fish Assemblages in Borrow-Pit Lakes of the Lower Mississippi River
SO TRANSACTIONS OF THE AMERICAN FISHERIES SOCIETY
LA English
DT Article
ID FLOODPLAIN ECOSYSTEMS; AQUATIC HABITATS; CONNECTIVITY; REPRODUCTION;
SYSTEM; RECRUITMENT; MANAGEMENT; AUSTRIA; RHINE; PONDS
AB Borrow-pit lakes encompass about a third of the lentic water habitats (by area) in the active floodplain of the Lower Mississippi River, yet little is known about their fish assemblages. We investigated whether fish assemblages supported by borrow-pit lakes resembled those in oxbow lakes to help place the ecological relevance of borrow-pit lakes in context with that of natural floodplain lakes. In all, we collected 75 fish species, including 65 species in eight borrow-pit lakes, 52 species in four riverside oxbow lakes, and 44 species in eight landside oxbow lakes. Significant differences in several species richness metrics were evident between borrow-pit lakes and landside oxbow lakes but not between borrow-pit lakes and riverside oxbow lakes. All three lake types differed in fish assemblage composition. Borrow-pit lakes and riverside oxbow lakes tended to include a greater representation of fish species that require access to diverse environments, including lentic, lotic, and palustrine habitats; fish assemblages in landside oxbow lakes included a higher representation of lacustrine species. None of the fish species collected in borrow-pit lakes was federally listed as threatened or endangered, but several were listed as species of special concern by state governments in the region, suggesting that borrow-pit lakes provide habitat for sensitive riverine and wetland fish species. Differences in fish assemblages among borrow-pit lakes were linked to engineered morphologic features, suggesting that diversity in engineering can contribute to diversity in fish assemblages; however, more research is needed to match engineering designs with fish assemblage structures that best meet conservation needs. Received September 21, 2012; accepted December 17, 2012
C1 [Miranda, L. E.] US Geol Survey, Mississippi Cooperat Fish & Wildlife Res Unit, Mississippi State, MS 39762 USA.
[Killgore, K. J.; Hoover, J. J.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
RP Miranda, LE (reprint author), US Geol Survey, Mississippi Cooperat Fish & Wildlife Res Unit, POB 9691, Mississippi State, MS 39762 USA.
EM smiranda@usgs.gov
FU USACE Mississippi Valley Division; ERDC Ecosystem Management and
Restoration Research Program
FX Selection and access to borrow-pit lakes were facilitated by the
following personnel of the U.S. Army Corps of Engineers (USACE)
Vicksburg District and USACE Memphis District: M. Cannon, S. McLean, L.
Hartzog, E. Lambert, K. Parrish, S. Reed, G. Williams, and G. Young.
Assistance with field sampling was provided by U.S. Army Engineer
Research and Development Center (ERDC) personnel, including R. Adams, S.
George, S. Harrel, J. Kirk, B. Lewis, J. Morrow, C. Murphy, T. Robinson,
and L. Sanders. Assistance in the field and with identification and
curation of juvenile and adult fishes was provided by N. Douglas
(University of Louisiana, Monroe). Funding for borrow-pit sampling was
provided by the USACE Mississippi Valley Division and the ERDC Ecosystem
Management and Restoration Research Program. B. Alford (Louisiana
Department of Wildlife and Fisheries) and G. Lucas (Mississippi
Department of Wildlife, Fisheries, and Parks) facilitated the oxbow
lakes data. The use of trade names or products does not constitute
endorsement by the U.S. Government.
NR 48
TC 0
Z9 0
U1 1
U2 16
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 0002-8487
J9 T AM FISH SOC
JI Trans. Am. Fish. Soc.
PD MAY 1
PY 2013
VL 142
IS 3
BP 596
EP 605
DI 10.1080/00028487.2012.760486
PG 10
WC Fisheries
SC Fisheries
GA 167OV
UT WOS:000320642200002
ER
PT J
AU McMichael, IT
Zaghloul, AI
Mirotznik, MS
AF McMichael, Ian T.
Zaghloul, Amir I.
Mirotznik, Mark S.
TI A Method for Determining Optimal EBG Reflection Phase for Low Profile
Dipole Antennas
SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
LA English
DT Article
DE Electromagnetic band gap (EBG); low profile antenna; reflection phase
AB An analytical method for determining the optimal reflection phase of an electromagnetic band gap (EBG) ground plane to match a low profile dipole antenna is introduced. Image theory is used to incorporate the near field coupling between a dipole antenna and the ground plane. The main contribution of this paper is to show that the optimal EBG reflection phase can be determined at discrete frequencies where a theoretically perfect return loss occurs. The optimal reflection phase is then obtained over a wider frequency band of interest and is related to the antenna's return loss for a given feed impedance and antenna height above the EBG. The resulting reflection phase can be used as a reference for designing an EBG ground plane that is well matched to the antenna without time consuming iterative full wave numerical simulations. Numerical modeling results are compared to the optimal return loss derived from the analytical method to validate the design process. It is also shown that, for certain antennas, vias are not always necessary in the construction of the EBG, which eases the manufacturing process. Finally, a dipole and EBG are constructed using the optimal design method and measurements are compared to the simulations.
C1 [McMichael, Ian T.] Univ Delaware, Newark, DE 19716 USA.
[McMichael, Ian T.] USA, CERDEC RDECOM NVESD, Ft Belvoir, VA 22060 USA.
[Zaghloul, Amir I.] USA, Res Lab, Adelphi, MD 20783 USA.
[Mirotznik, Mark S.] Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA.
RP McMichael, IT (reprint author), Univ Delaware, Newark, DE 19716 USA.
EM mirotzni@ece.udel.edu
NR 8
TC 7
Z9 7
U1 0
U2 12
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-926X
J9 IEEE T ANTENN PROPAG
JI IEEE Trans. Antennas Propag.
PD MAY
PY 2013
VL 61
IS 5
BP 2411
EP 2417
DI 10.1109/TAP.2013.2244552
PG 7
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA 157BP
UT WOS:000319870700007
ER
PT J
AU Heegard, KD
Tilley, MA
Stewart, IJ
Edgecombe, HP
Lundy, JB
Renz, EM
Chung, KK
AF Heegard, Kelly D.
Tilley, Molly A.
Stewart, Ian J.
Edgecombe, Harcourt P.
Lundy, Jonathan B.
Renz, Evan M.
Chung, Kevin K.
TI Anaphylactoid reaction during first hemofiltration with a PUREMA (R)
polysulfone membrane
SO INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
LA English
DT Article
DE Hemodialysis; Hemo filtration; Hypersensitivity reaction; Acute kidney
injury; Dialyzer reaction
ID HYPERSENSITIVITY REACTIONS; HEMODIALYSIS; DIALYZER
AB Adverse reactions during hemodialysis are extremely common and include a wide range of clinical presentations from mild to life threatening. We present a case of a 34 year old woman in the Burn Intensive Care Unit, who developed acute kidney injury requiring renal replacement therapy. She was placed on continuous veno-venous hemofiltration with the NxStage (R) machine which uses a synthetic PUREMA (R) polyethersulfone filter sterilized by gamma radiation. Within two minutes of initiating hemofiltration, the patient complained of pruritus as well as dyspnea and became flushed and agitated. She subsequently developed hypotension ultimately resulting in cardiopulmonary arrest. Cardiopulmonary resuscitation was initiated and the patient was given epinephrine with return of spontaneous circulation. The following day, the patient was rechallenged with a PUREMA (R) filter, and had a similar reaction with flushing, dyspnea, pruritus and hypotension requiring treatment to be discontinued. The patient was transitioned to the Prismaflex filter, another synthetic membrane, which she tolerated well and continued to utilize through the remainder of her hospital course without complication. Her clinical presentation was consistent with an anaphylactoid reaction, though a tryptase level was not obtained and a radioallergosorbent test performed with membrane material was negative. This case shows the difficulty of identifying the cause of hypersensitivity reactions involving synthetic membranes not sterilized by ethylene oxide, a commonly use sterilizing agent known to cause hypersensitivity reactions. This rare, but potentially fatal reaction has not previously been reported with a PUREMA (R) filter and this case should raise awareness of hypersensitivity reactions with this widely used method of renal replacement therapy.
C1 [Heegard, Kelly D.; Tilley, Molly A.; Stewart, Ian J.] San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA.
[Edgecombe, Harcourt P.; Lundy, Jonathan B.; Renz, Evan M.; Chung, Kevin K.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
RP Stewart, IJ (reprint author), San Antonio Mil Med Ctr, ATTN Nephrol, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM ian.stewart@us.af.mil
NR 13
TC 6
Z9 6
U1 1
U2 10
PU WICHTIG EDITORE
PI MILAN
PA 72/74 VIA FRIULI, 20135 MILAN, ITALY
SN 0391-3988
J9 INT J ARTIF ORGANS
JI Int. J. Artif. Organs
PD MAY
PY 2013
VL 36
IS 5
BP 363
EP 366
DI 10.5301/ijao.5000136
PG 4
WC Engineering, Biomedical; Transplantation
SC Engineering; Transplantation
GA 168DD
UT WOS:000320685000009
PM 23420464
ER
PT J
AU Doyle, K
Swartz, CH
Dinan, JH
Myers, TH
Brill, G
Chen, YP
VanMil, BL
Wijewarnasuriya, P
AF Doyle, Kevin
Swartz, Craig H.
Dinan, John H.
Myers, Thomas H.
Brill, Gregory
Chen, Yuanping
VanMil, Brenda L.
Wijewarnasuriya, Priyalal
TI Mercury cadmium selenide for infrared detection
SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B
LA English
DT Article
AB Samples of HgCdSe alloys were grown via molecular beam epitaxy on thick ZnTe buffer layers on Si substrates. Two Se sources were used: an effusion cell loaded with 5N source material that produced a predominantly Se-6 beam and a cracker loaded with 6N material that could produce a predominantly Se-2 beam. The background electron concentration in as-grown samples was significantly reduced by switching to the Se cracker source, going from 10(17)-10(18) cm(-3) to 3-5 x 10(16) cm(-3) at 12 K. The concentration remained low even when the cracking zone temperature was lowered to produce a predominantly Se-6 beam, which strongly suggests that a major source of donor defects is impurities from the Se source material rather than Se species. Secondary ion mass spectroscopy was performed. Likely donors such as F, Br, and Cl were detected at the ZnTe interface while C, O, and Si were found at the interface and in the top 1.5 mu m from the surface in all samples measured. The electron concentration for all samples increased when annealed in a Cd or Hg overpressure and decreased when annealed under Se. This suggests the presence of native defects such as vacancies and interstitials in addition to impurities. Overall, by switching to higher purity Se material and then annealing under Se overpressures, the background electron concentration was reduced by an order of magnitude, with the lowest value achieved being 9.4 x 10(15) cm(-3) at 12 K. (C) 2013 American Vacuum Society.
C1 [Doyle, Kevin; Swartz, Craig H.; Dinan, John H.; Myers, Thomas H.] Texas State Univ San Marcos, Mat Sci Engn & Commercializat Program, San Marcos, TX 78666 USA.
[Brill, Gregory; Chen, Yuanping; VanMil, Brenda L.; Wijewarnasuriya, Priyalal] USA, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20786 USA.
RP Doyle, K (reprint author), Texas State Univ San Marcos, Mat Sci Engn & Commercializat Program, 749 N Commanche St, San Marcos, TX 78666 USA.
EM Kevin.doyle.30.ctr@mail.mil
RI Brill, Gregory/G-4877-2013; Myers, Thomas/C-3769-2013
FU US Army Research Laboratory; US Army Research Office [W911NF-10-2-0103,
W911NF-10-1-0335]; Air Force Office of Scientific Research; Charles
Evans Analytical Group [C0CGM100]
FX Portions of this work were supported by the US Army Research Laboratory
and the US Army Research Office under Contract/Grant Nos.
W911NF-10-2-0103 and W911NF-10-1-0335. Additional funding was provided
by the Air Force Office of Scientific Research. SIMS measurements were
performed by the Charles Evans Analytical Group under contract number
C0CGM100.
NR 10
TC 1
Z9 2
U1 1
U2 29
PU A V S AMER INST PHYSICS
PI MELVILLE
PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA
SN 1071-1023
J9 J VAC SCI TECHNOL B
JI J. Vac. Sci. Technol. B
PD MAY
PY 2013
VL 31
IS 3
AR 03C124
DI 10.1116/1.4798651
PG 5
WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology;
Physics, Applied
SC Engineering; Science & Technology - Other Topics; Physics
GA 160PB
UT WOS:000320130500024
ER
PT J
AU Novikov, SV
Yu, KM
Levander, A
Detert, D
Sarney, WL
Liliental-Weber, Z
Shaw, M
Martin, RW
Svensson, SP
Walukiewicz, W
Foxon, CT
AF Novikov, Sergei V.
Yu, Kin M.
Levander, Alejandro
Detert, Douglas
Sarney, Wendy L.
Liliental-Weber, Zuzanna
Shaw, Martin
Martin, Robert W.
Svensson, Stefan P.
Walukiewicz, Wladek
Foxon, C. Thomas
TI Molecular beam epitaxy of highly mismatched N-rich GaN1-xSbx and
InN1-xAsx alloys
SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B
LA English
DT Article
AB GaN materials alloyed with group V anions form the so-called highly mismatched alloys (HMAs). Recently, the authors succeeded in growing N-rich GaN1-xAsx and GaN1-xBix alloys over a large composition range by plasma-assisted molecular beam epitaxy (PA-MBE). Here, they present first results on PA-MBE growth and properties of N-rich GaN1-xSbx and InN1-xAsx alloys and compare these with GaN1-xAsx and GaN1-xBix alloys. The enhanced incorporation of As and Sb was achieved by growing the layers at extremely low growth temperatures. Although layers become amorphous for high As, Sb, and Bi content, optical absorption measurements show a progressive shift of the optical absorption edge to lower energy. The large band gap range and controllable conduction and valence band positions of these HMAs make them promising materials for efficient solar energy conversion devices. (C) 2013 American Vacuum Society.
C1 [Novikov, Sergei V.; Foxon, C. Thomas] Univ Nottingham, Sch Phys & Astron, Nottingham NG7 2RD, England.
[Yu, Kin M.; Levander, Alejandro; Detert, Douglas; Liliental-Weber, Zuzanna; Walukiewicz, Wladek] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA.
[Levander, Alejandro; Detert, Douglas] Univ Calif Berkeley, Dept Mat Sci & Engn, Berkeley, CA 94720 USA.
[Sarney, Wendy L.; Svensson, Stefan P.] USA, Res Lab, Adelphi, MD 20783 USA.
[Shaw, Martin; Martin, Robert W.] Univ Strathclyde, SUPA, Dept Phys, Glasgow G4 0NG, Lanark, Scotland.
RP Novikov, SV (reprint author), Univ Nottingham, Sch Phys & Astron, Nottingham NG7 2RD, England.
EM Sergei.Novikov@nottingham.ac.uk
RI martin, rob/A-7127-2010;
OI martin, rob/0000-0002-6119-764X; Yu, Kin Man/0000-0003-1350-9642
FU EPSRC; Office of Science, Office of Basic Energy Sciences, Materials
Sciences and Engineering Division, of the U.S. Department of Energy
[DE-AC02-05CH11231]
FX The MBE growth at the University of Nottingham and characterization at
the University of Strathclyde were undertaken with support from the
EPSRC. Material characterization work performed at LBNL was supported by
the Director, Office of Science, Office of Basic Energy Sciences,
Materials Sciences and Engineering Division, of the U.S. Department of
Energy under Contract No. DE-AC02-05CH11231.
NR 11
TC 3
Z9 3
U1 0
U2 13
PU A V S AMER INST PHYSICS
PI MELVILLE
PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA
SN 1071-1023
J9 J VAC SCI TECHNOL B
JI J. Vac. Sci. Technol. B
PD MAY
PY 2013
VL 31
IS 3
AR 03C102
DI 10.1116/1.4774028
PG 5
WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology;
Physics, Applied
SC Engineering; Science & Technology - Other Topics; Physics
GA 160PB
UT WOS:000320130500002
ER
PT J
AU Onoye, J
Helm, S
Koyanagi, C
Fukuda, M
Hishinuma, E
Takeshita, J
Ona, C
AF Onoye, Jane
Helm, Susana
Koyanagi, Chad
Fukuda, Michael
Hishinuma, Earl
Takeshita, Junji
Ona, Celia
TI Proportional Differences in Emergency Room Adult Patients with PTSD,
Mood Disorders, and Anxiety for a Large Ethnically Diverse Geographic
Sample
SO JOURNAL OF HEALTH CARE FOR THE POOR AND UNDERSERVED
LA English
DT Article
DE Mental health; health services; ethnicity; emergency services; rural
ID POSTTRAUMATIC-STRESS-DISORDER; COMORBIDITY SURVEY REPLICATION;
MENTAL-HEALTH-SERVICES; DSM-IV DISORDERS; PSYCHIATRIC-DISORDERS;
LIFETIME PREVALENCE; WAR VETERANS; PRIMARY-CARE; COMBAT; IRAQ
AB Underserved populations often utilize the emergency room in place of primary care, particularly for short term behavioral health services. This study examined emergency department (ED) utilization rates for rurality, insurance, sex, and ethnicity in a large sample of adult patients in Hawai'i hospitals from 2000-2010 with a diagnosis of post-traumatic stress disorder (PTSD), mood disorder, or other anxiety disorder. Findings showed a higher rate of use by rural and suburban residents with a diagnosis of PTSD or other anxiety than by urban residents. Utilization of EDs by African Americans and Other Pacific Islanders with PTSD was proportionally higher than for those with mood disorders or other anxiety disorders. Military ED visits were also proportionally higher for individuals with PTSD than for those with mood or other anxiety disorders. Limited economic resources and increasingly costly mental health disorders such as PTSD highlight the importance of better understanding the needs for behavioral health services for underserved populations.
C1 [Onoye, Jane; Helm, Susana; Koyanagi, Chad; Fukuda, Michael; Hishinuma, Earl; Takeshita, Junji] Univ Hawaii Manoa, Dept Psychiat, John A Burns Sch Med, Honolulu, HI 96813 USA.
[Koyanagi, Chad; Takeshita, Junji] Queens Med Ctr, Honolulu, HI 96813 USA.
[Ona, Celia] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
RP Onoye, J (reprint author), Univ Hawaii Manoa, Dept Psychiat, John A Burns Sch Med, 1356 Lusitana St,4th Floor, Honolulu, HI 96813 USA.
EM onoyej@dop.hawaii.edu
NR 44
TC 1
Z9 1
U1 0
U2 2
PU JOHNS HOPKINS UNIV PRESS
PI BALTIMORE
PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD
21218-4363 USA
SN 1049-2089
J9 J HEALTH CARE POOR U
JI J. Health Care Poor Underserved
PD MAY
PY 2013
VL 24
IS 2
BP 928
EP 942
PG 15
WC Health Policy & Services; Public, Environmental & Occupational Health
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health
GA 153VU
UT WOS:000319631400040
PM 23728057
ER
PT J
AU Cazacu, O
Stewart, JB
AF Cazacu, Oana
Stewart, Joel B.
TI Analytical criterion for porous solids containing cylindrical voids in
an incompressible matrix exhibiting tension compression asymmetry
SO PHILOSOPHICAL MAGAZINE
LA English
DT Article
DE voids shape; third-invariant effects; deformation twinning; porous media
ID YIELD CRITERION; PLASTIC-DEFORMATION; MECHANICAL RESPONSE; DUCTILE
FRACTURE; CONSTITUTIVE LAW; POLYCRYSTALS; EVOLUTION; ZIRCONIUM; TEXTURE;
METALS
AB A new analytic plastic potential is developed using a rigorous limit analysis approach. Conditions of homogeneous boundary strain rate are imposed on every cylinder concentric with the cavity. It is shown that, due to the tensioncompression asymmetry of the incompressible matrix, the third invariant of the stress deviator has a strong influence on the yielding of the porous solid. New and intriguing results are obtained; namely, for axisymmetric loadings and plane strain conditions, the stress state at yielding is not hydrostatic. In the case when the matrix has the same yield in tension as in compression, the new criterion reduces to Gurson's criterion for cylindrical voids.
C1 [Cazacu, Oana] Univ Florida REEF, Dept Mech & Aerosp Engn, Shalimar, FL 32539 USA.
[Stewart, Joel B.] USA, Res Lab, Aberdeen, MD 21005 USA.
RP Cazacu, O (reprint author), Univ Florida REEF, Dept Mech & Aerosp Engn, 1350 N Poquito Rd, Shalimar, FL 32539 USA.
EM cazacu@reef.ufl.edu
RI Cazacu, Oana/L-4635-2016;
OI Cazacu, Oana/0000-0002-2499-9096; Stewart, Joel/0000-0002-1723-7106
NR 31
TC 2
Z9 2
U1 1
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1478-6435
EI 1478-6443
J9 PHILOS MAG
JI Philos. Mag.
PD MAY 1
PY 2013
VL 93
IS 13
BP 1520
EP 1548
DI 10.1080/14786435.2012.746792
PG 29
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering; Physics, Applied; Physics, Condensed Matter
SC Materials Science; Metallurgy & Metallurgical Engineering; Physics
GA 146RX
UT WOS:000319109600005
ER
PT J
AU Foran, HM
Garber, BG
Zamorski, MA
Wray, M
Mulligan, K
Greenberg, N
Castro, CA
Adler, AB
AF Foran, Heather M.
Garber, Bryan G.
Zamorski, Mark A.
Wray, Mariane
Mulligan, Kathleen
Greenberg, Neil
Castro, Carl Andrew
Adler, Amy B.
TI Postdeployment Military Mental Health Training: Cross-National
Evaluations
SO PSYCHOLOGICAL SERVICES
LA English
DT Article
DE military personnel; prevention; mental health training; deployment; user
satisfaction
ID COMBAT DEPLOYMENT; ARMED-FORCES; IRAQ; INTERVENTIONS; AFGHANISTAN;
PREVALENCE; COMPONENT; PROGRAM; CARE
AB Deployments increase risk for adjustment problems in service members. To mitigate this increased risk, mental health training programs have been developed and implemented in several nations. As part of a coordinated effort, three nations adapted a U. S. mental health training program that had been validated by a series of group randomized trials demonstrating improvement in postdeployment adjustment. Implementation of evidence-based programs in a new context is challenging: How much of the original program needs to remain intact in order to retain its utility? User satisfaction rates can provide essential data to assess how well a program is accepted. This article summarizes service member ratings of postdeployment mental health training and compares ratings from service members across four nations. The participating nations (Canada, New Zealand, United Kingdom, and the United States) administered mental health training to active duty military personnel in their respective nations. Following the training, military personnel completed an evaluation of the training. Overall, across the four nations, more than 70% of military personnel agreed or strongly agreed that they were satisfied with the mental health training. Although some differences in evaluations were observed across nations, components of training that were most important to overall satisfaction with the training were strikingly similar across nations. Fundamentally, it appears feasible that despite cultural and organizational differences, a mental health training program developed in one nation can be successfully adapted for use in other nations.
C1 [Foran, Heather M.; Adler, Amy B.] Walter Reed Army Inst Res, US Army Med Res Unit Europe, Heidelberg, Germany.
[Garber, Bryan G.; Zamorski, Mark A.] Canadian Forces Hlth Serv Grp, Ottawa, ON, Canada.
[Wray, Mariane] Headquarters Joint Forces New Zealand, Wellington, New Zealand.
[Mulligan, Kathleen; Greenberg, Neil] Kings Coll London, Acad Ctr Def Mental Hlth, Weston Educ Ctr, London WC2R 2LS, England.
[Castro, Carl Andrew] USA, Mil Operat Med Res Program, Med Res & Mat Command, Frederick, MD USA.
RP Foran, HM (reprint author), USA, Med Res Unit Europe, APO, AE 09042 USA.
EM heather.m.foran.ctr@us.army.mil
NR 21
TC 2
Z9 2
U1 1
U2 6
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 1541-1559
J9 PSYCHOL SERV
JI Psychol. Serv.
PD MAY
PY 2013
VL 10
IS 2
SI SI
BP 152
EP 160
DI 10.1037/a0032609
PG 9
WC Psychology, Clinical
SC Psychology
GA 156DW
UT WOS:000319802300003
PM 23730961
ER
PT J
AU Ben Barnes, J
Nickerson, A
Adler, AB
Litz, BT
AF Ben Barnes, J.
Nickerson, Angela
Adler, Amy B.
Litz, Brett T.
TI Perceived Military Organizational Support and Peacekeeper Distress: A
Longitudinal Investigation
SO PSYCHOLOGICAL SERVICES
LA English
DT Article
DE stress; posttraumatic stress; perceived organizational support;
peacekeeping; structural equation modeling
ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; SOCIAL SUPPORT;
DEPRESSION; SYMPTOMS; PTSD; IRAQ; SYMPTOMATOLOGY; RESILIENCE; TRAUMA
AB Many professions vital to the safety of society require workers to face high magnitude and potentially traumatizing events. Because this routine exposure can cause high levels of stress in workers, it is important to investigate factors that contribute to both risk of posttraumatic stress disorder (PTSD), and healthy responses to stress. Although some research has found social support to mitigate the effects of posttraumatic stress symptoms, scant research has investigated organizational support. The aim of the present study is to investigate the temporal relationship between stress symptoms and perceived organizational support in a sample of 1,039 service members deployed to the peacekeeping mission to Kosovo. Participants completed self-report measures of stress symptoms and perceived organizational support at 4 study time points. Bivariate latent difference score structural equation modeling was utilized to examine the temporal relationship among stress and perceived organizational support. In general, across the 4 time points, latent PCL scores evidenced a salient and negative relationship to subsequent POS latent difference scores. However, no significant relationship was found between latent POS variables and subsequent PCL latent difference scores. Findings suggest that prior stress symptoms are influencing service member's perceptions of the supportiveness of their organization such that increased prior stress is associated with worsening perceptions of support. These results illustrate that targeting stress directly may potentiate the positive influence of organizational support and that institutional support programs should be adapted to better account for the negative biases increased distress may encourage.
C1 [Ben Barnes, J.; Litz, Brett T.] VA Boston Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr, Boston, MA 02130 USA.
[Nickerson, Angela] Univ New S Wales, Sch Psychol, Sydney, NSW, Australia.
[Adler, Amy B.] Walter Reed Army Inst Res, US Army Med Res Unit Europe, Heidelberg, Germany.
[Litz, Brett T.] Boston Univ, Dept Psychiat, Boston, MA 02215 USA.
RP Litz, BT (reprint author), VA Boston Healthcare Syst, Vet Epidemiol Res & Informat Ctr, 150 South Huntington Ave 116-B4, Boston, MA 02130 USA.
EM brett.litz@va.gov
NR 50
TC 0
Z9 0
U1 2
U2 20
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 1541-1559
EI 1939-148X
J9 PSYCHOL SERV
JI Psychol. Serv.
PD MAY
PY 2013
VL 10
IS 2
SI SI
BP 177
EP 185
DI 10.1037/a0032607
PG 9
WC Psychology, Clinical
SC Psychology
GA 156DW
UT WOS:000319802300006
ER
PT J
AU Holthoff, EL
Farrell, ME
Pellegrino, PM
AF Holthoff, Ellen L.
Farrell, Mikella E.
Pellegrino, Paul M.
TI Standardized Sample Preparation Using a Drop-on-Demand Printing Platform
SO SENSORS
LA English
DT Article
DE drop-on-demand; inkjet printing; sample preparation
ID TECHNOLOGY
AB Hazard detection systems must be evaluated with appropriate test material concentrations under controlled conditions in order to accurately identify and quantify unknown residues commonly utilized in theater. The existing assortment of hazard reference sample preparation methods/techniques presents a range of variability and reproducibility concerns, making it increasingly difficult to accurately assess optically-based detection technologies. To overcome these challenges, we examined the optimization, characterization, and calibration of microdroplets from a drop-on-demand microdispenser that has a proven capability for the preparation of energetic reference materials. Research presented herein focuses on the development of a simplistic instrument calibration technique and sample preparation protocol for explosive materials testing based on drop-on-demand technology. Droplet mass and reproducibility were measured using ultraviolet-visible (UV-Vis) absorption spectroscopy. The results presented here demonstrate the operational factors that influence droplet dispensing for specific materials (e. g., energetic and interferents). Understanding these parameters permits the determination of droplet and sample uniformity and reproducibility (typical R-2 values of 0.991, relative standard deviation or RSD >= 5%), and thus the demonstrated maturation of a successful and robust methodology for energetic sample preparation.
C1 [Holthoff, Ellen L.; Farrell, Mikella E.; Pellegrino, Paul M.] USA, Res Lab, RDRL SEE E, Adelphi, MD 20783 USA.
RP Holthoff, EL (reprint author), USA, Res Lab, RDRL SEE E, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM ellen.l.holthoff.civ@mail.mil; mikella.e.farrell.civ@mail.mil;
paul.m.pellegrino.civ@mail.mil
NR 27
TC 9
Z9 9
U1 1
U2 25
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1424-8220
J9 SENSORS-BASEL
JI Sensors
PD MAY
PY 2013
VL 13
IS 5
BP 5814
EP 5825
DI 10.3390/s130505814
PG 12
WC Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation
SC Chemistry; Electrochemistry; Instruments & Instrumentation
GA 151FH
UT WOS:000319445600025
PM 23653050
ER
PT J
AU Prat, N
Pidcoke, HF
Sailliol, A
Cap, AP
AF Prat, N.
Pidcoke, H. F.
Sailliol, A.
Cap, A. P.
TI Evolution of US military transfusion support for resuscitation of trauma
and hemorrhagic shock
SO TRANSFUSION CLINIQUE ET BIOLOGIQUE
LA French
DT Article
DE Damage control resuscitation; Hemorrhagic shock; Acute coagulopathy of
trauma; Joint Theater Trauma Registry; Fresh whole blood; 1:1:1
component therapy; Platelet:RBC; FFP:RBC; Freeze-dried plasma;
Tranexamic acid
ID ABDOMINAL COMPARTMENT SYNDROME; FRESH WHOLE-BLOOD; DAMAGE-CONTROL
RESUSCITATION; COMBAT CASUALTY CARE; ACTIVATED FACTOR-VII; RECEIVING
MASSIVE TRANSFUSIONS; EXTREMITY ARTERIAL HEMORRHAGE; EMERGENCY
TOURNIQUET USE; RECOMBINANT FACTOR VIIA; CLOT-INDUCING MINERALS
AB Military conflicts create a dynamic medical environment in which the number of severe trauma cases is compressed in both time and space. In consequence, lessons are learned at a rapid pace. Because the military has an effective organizational structure at its disposal and the logistical capacity to rapidly disseminate new ideas, adoption of novel therapies and protective equipment occurs quickly. The recent conflicts in Iraq and Afghanistan are no exception: more than three dozen new clinical practice guidelines were implemented by the US Armed Forces, with attendant survival benefits, in response to observation and research by military physicians. Here we review the lessons learned by coalition medical personnel regarding resuscitation of severe trauma, integrating knowledge gained from massive transfusion, autopsies, and extensive review of medical records contained in the Joint Theater Trauma Registry. Changes in clinical care included the shift to resuscitation with 1:1:1 component therapy, use of fresh whole blood, and the application of both medical devices and pharmaceutical adjuncts to reduce bleeding. Future research will focus on emerging concepts regarding coagulopathy of trauma and evaluation of promising new blood products for far-forward resuscitation. New strategies aimed at reducing mortality on the battlefield will focus on resuscitation in the pre-hospital setting where hemorrhagic death continues to be a major challenge. (C) 2013 Elsevier Masson SAS. All rights reserved.
C1 [Prat, N.; Pidcoke, H. F.; Cap, A. P.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Prat, N.] Inst Rech Biomed Armees, F-91223 Bretigny Sur Orge, France.
[Sailliol, A.] Ctr Transfus Sanguine Armees, F-92141 Clamart, France.
RP Prat, N (reprint author), USA, Inst Surg Res, 3650 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM nicolas.prat@mac.com
RI PRAT, Nicolas/R-4213-2016
NR 90
TC 1
Z9 1
U1 2
U2 15
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 1246-7820
J9 TRANSFUS CLIN BIOL
JI Transfu. Clin. Biol.
PD MAY
PY 2013
VL 20
IS 2
BP 225
EP 230
DI 10.1016/j.tracli.2013.02.003
PG 6
WC Hematology; Immunology
SC Hematology; Immunology
GA 158YP
UT WOS:000320011400029
PM 23597584
ER
PT J
AU Hancock, PA
Mercado, JE
Merlo, J
Van Erp, JBF
AF Hancock, Peter A.
Mercado, Joseph E.
Merlo, James
Van Erp, Jan B. F.
TI Improving target detection in visual search through the augmenting
multi-sensory cues
SO ERGONOMICS
LA English
DT Article
DE auditory cueing; tactile cueing; augmented support; target detection;
visual search
ID TACTILE; ATTENTION; PERFORMANCE; INFORMATION; WORKLOAD; DISPLAYS;
GUIDANCE; FEEDBACK; ACQUISITION; INTEGRATION
AB The present experiment tested 60 individuals on a multiple screen, visual target detection task. Using a within-participant design, individuals received no-cue augmentation, an augmenting tactile cue alone, an augmenting auditory cue alone or both of the latter augmentations in combination. Results showed significant and substantive improvements in performance such that successful search speed was facilitated by more than 43%, errors of omission were reduced by 86% and errors of commission were reduced by more than 77% in the combinatorial cueing condition compared with the non-cued control. These outcomes were not a trade of performance efficiency for associated mental effort because recorded levels of cognitive workload were also reduced by more than 30% in the multi-cued circumstance compared with the control condition. When the tactile modality was incorporated it led to the highest gain in performance speed, when the auditory modality was incorporated, it led to the best levels of performance accuracy. The combined condition rendered the best of each from of performance increment. Reasons for this outcome pattern are discussed alongside their manifest practical benefits.
Practitioner Summary: This experiment tested 60 individuals on a multiple screen, visual target detection task. Individuals received no-cue augmentation, tactile cue alone, an augmenting auditory cue alone or both of the latter augmentations in combination. Results showed significant and substantive improvements in the combinatorial cueing condition compared with the non-cued control.
C1 [Hancock, Peter A.] Univ Cent Florida, Dept Psychol, Orlando, FL 32816 USA.
[Mercado, Joseph E.; Merlo, James] US Mil Acad, West Point, NY 10996 USA.
[Van Erp, Jan B. F.] Netherlands Org Appl Sci Res TNO, Soesterberg, Netherlands.
RP Mercado, JE (reprint author), US Mil Acad, West Point, NY 10996 USA.
EM jmercado85@gmail.com
OI van Erp, Jan/0000-0002-6511-2850
FU Army Research Office [W911NF-08-1-0196]
FX We would like to thank Cadets from the Engineering Psychology Program at
the USMA for their diligence in creating the stimuli for the experiment
and helping to collect the data for the present experiment. Our thanks
are also due to Dr Aaron Duley for his LabView programming, which
enabled the experimental protocol. The work was supported by the
government contract number W911NF-08-1-0196, Adaptation of Physiological
and Cognitive Workload via Interactive Multi-Modal Displays from the
Army Research Office, P.A. Hancock, Principal Investigator. Dr Elmar
Schmeisser was the Technical Monitor for the grant. The views expressed
in this work are those of the authors and do not necessarily reflect
official Army policy.
NR 55
TC 11
Z9 11
U1 3
U2 18
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0014-0139
J9 ERGONOMICS
JI Ergonomics
PD MAY 1
PY 2013
VL 56
IS 5
BP 729
EP 738
DI 10.1080/00140139.2013.771219
PG 10
WC Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology
SC Engineering; Psychology
GA 146RD
UT WOS:000319107300001
PM 23510197
ER
PT J
AU Yost, TL
Taylor, AG
AF Yost, Terri L.
Taylor, Ann Gill
TI QIGONG AS A NOVEL INTERVENTION FOR SERVICE MEMBERS WITH MILD TRAUMATIC
BRAIN INJURY
SO EXPLORE-THE JOURNAL OF SCIENCE AND HEALING
LA English
DT Review
DE Mild traumatic brain injury; mTBI; qigong; reflective exercise;
phenomenology; military
ID POSTTRAUMATIC-STRESS-DISORDER; RANDOMIZED CLINICAL-TRIALS;
ESSENTIAL-HYPERTENSION; EXTERNAL QIGONG; TAI-CHI; SYMPTOMS; PAIN;
THERAPY; BLOOD
AB Purpose: To describe the experience of internal qigong practice in service members diagnosed with mild traumatic brain injury (mTBI).
Theoretical Framework: The study used qualitative descriptive phenomenological methods originally described by Husserl and later refined by Giorgi.
Methodology: Participants were interviewed about their experiences while learning qigong to determine their level of interest, benefits, and/or adverse effects; ease of learning/performing the routine; and any barriers to practice.
Sample: Six service members with mTBI receiving outpatient neurorehabilitation at the Defense and Veterans Brain Injury Center-Charlottesville Rehabilitation Center.
Intervention: Participants learned Reflective Exercise Qigong, a form of qigong developed specifically to require less complex movement and balance than most forms of qigong, making it ideal for those with potential coordination and balance issues.
Data Collection: Semistructured interviews took place after four weeks of formal qigong instruction, then again after the subjects completed eight weeks. Interview data were analyzed with phenomenological methods described by Giorgi.
Results: Four themes emerged from the interview data: "the physical experience of qigong," "regaining control," "no pain, a lot of gain," and "barriers to qigong practice." Participants offered examples of how qigong enabled them to control refractory symptoms after mTBI while decreasing reliance on pharmacotherapy. All agreed that qigong was uniquely conducive to the disciplined mindset of military service members and that the simplicity of Reflective Exercise qigong, compared with similar modalities such as tai chi and yoga, was well suited to individuals with decreased balance, cognition, and memory related to mTBI.
C1 [Yost, Terri L.] Tripler Army Med Ctr, Ctr Nursing Sci & Clin Inquiry, Honolulu, HI 96859 USA.
[Taylor, Ann Gill] Univ Virginia, Ctr Study Complementary & Alternat Therapies, Charlottesville, VA USA.
RP Yost, TL (reprint author), Tripler Army Med Ctr, Ctr Nursing Sci & Clin Inquiry, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM terri.yost@us.army.mil
FU TriService Nursing Research Program grant [HU0001-1-10-TS13]
FX The authors thank the Defense and Veterans Brain Injury Center (DVBIC)
and its Charlottesville facility leadership: Dr Don Nidiffer, Dr Jeffrey
Barth, and Dr Tina Trudel, as well as all of the providers and staff of
the DVBIC-Charlottesville Rehabilitation Program who were integral in
facilitating this research. This research was sponsored by the
TriService Nursing Research Program grant #HU0001-1-10-TS13, Uniformed
Services University of the Health Sciences; however, the information or
content and conclusions do not necessarily represent the official
position or policy of, nor should any official endorsement be inferred
by, the TriService Nursing Research Program, the Uniformed Services
University of the Health Sciences, the Department of Defense, or the
U.S. government.
NR 33
TC 1
Z9 1
U1 5
U2 20
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1550-8307
J9 EXPLORE-NY
JI Explore-J Sci. Heal.
PD MAY-JUN
PY 2013
VL 9
IS 3
BP 142
EP 149
DI 10.1016/j.explore.2013.02.002
PG 8
WC Integrative & Complementary Medicine
SC Integrative & Complementary Medicine
GA 150FJ
UT WOS:000319375300005
PM 23643369
ER
PT J
AU Chad, DA
Bidichandani, S
Bruijn, L
Capra, JD
Dickie, B
Ferguson, J
Figlewicz, D
Forsythe, M
Kaufmann, P
Kirshner, A
Monti, W
AF Chad, David A.
Bidichandani, Sanjay
Bruijn, Lucie
Capra, J. Donald
Dickie, Brian
Ferguson, John
Figlewicz, Denise
Forsythe, Melissa
Kaufmann, Petra
Kirshner, Annette
Monti, William
TI Funding agencies and disease organizations: Resources and
recommendations to facilitate ALS clinical research
SO AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
LA English
DT Article
DE ALS; funding agencies; patient voluntary organizations
AB Ten groups presented their perspectives on facilitating clinical research in ALS including four federal agencies, four disease organizations, one foundation and one advocacy group. The federal agencies (National Institute of Neurological Disorders and Stroke, National Institute of Environmental Health Sciences, Office of Rare Diseases Research, Department of Defense) encourage fostering a team approach between pre-clinical and clinical research investigators, coordinating with patient groups in the early phases of clinical studies, enhancing private and public partnerships, and investigating the interplay between genetic susceptibility and environmental exposure. The disease organizations (Muscular Dystrophy Association, ALS Association, ALS Society of Canada, and the Motor Neurone Disease Association UK) support fellowship training programs to develop ALS clinician scientists, and encourage work on the epidemiology of ALS, on genetic and epigenetic mechanisms that are relevant to ALS pathogenesis, on developing ALS registries and biobanks, and building bridges of collaboration among study groups. The Foundation supports innovative projects, including stem-cell research, and Patient Advocacy is committed to supporting excellence in ALS research and patient care, and believes strongly in enhancing communication between patients and members of the research community.
C1 [Chad, David A.] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA.
[Dickie, Brian] Motor Neuron Dis Assoc, Northampton, England.
[Ferguson, John] NIH, Off Rare Dis Res, Bethesda, MD 20892 USA.
[Figlewicz, Denise] ALS Soc Canada, Bethesda, MD USA.
[Forsythe, Melissa] USA, Med Res & Mat Command, Congressionally Directed Med Res Programs Off, Bethesda, MD USA.
[Kaufmann, Petra] NINDS, NIH, Bethesda, MD 20892 USA.
[Kirshner, Annette] NIEHS, NIH, Bethesda, MD USA.
[Monti, William] ALS Advocacy, New York, NY USA.
RP Chad, DA (reprint author), Neuromuscular Diagnost Ctr, 165 Cambridge St,Suite 820,CPZ 8, Boston, MA 02114 USA.
EM dchad@partners.org
NR 0
TC 1
Z9 1
U1 0
U2 9
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 2167-8421
J9 AMYOTROPH LAT SCL FR
JI Amyotroph. Lateral Scher. Frontotemp. Degenerat.
PD MAY
PY 2013
VL 14
SU 1
BP 62
EP 66
DI 10.3109/21678421.2013.778588
PG 5
WC Clinical Neurology
SC Neurosciences & Neurology
GA 145KH
UT WOS:000319014100007
PM 23678881
ER
PT J
AU Cai, XP
Servinsky, M
Kiel, J
Sund, C
Bennett, GN
AF Cai, Xianpeng
Servinsky, Matthew
Kiel, James
Sund, Christian
Bennett, George N.
TI Analysis of redox responses during TNT transformation by Clostridium
acetobutylicum ATCC 824 and mutants exhibiting altered metabolism
SO APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
LA English
DT Article
DE Electron mediators; Metabolism; Redox; Anaerobe; Hydrogenase
ID FE-ONLY HYDROGENASE; ESCHERICHIA-COLI; CONTINUOUS CULTURES; CONTAMINATED
SOIL; SOLVENT FORMATION; ACETONE FORMATION; ELECTRON FLOW;
2,4,6-TRINITROTOLUENE; MUTAGENICITY; REDUCTION
AB The transformation of trinitrotoluene (TNT) by several mutant strains of Clostridium acetobutylicum has been examined to analyze the maximal rate of initial transformation, determine the effects of metabolic mutations of the host on transformation rate, and to assess the cell metabolic changes brought about during TNT transformation. Little difference in the maximal rate of TNT degradation in early acid phase cultures was found between the parental ATCC 824 strain and strains altered in the acid forming pathways (phosphotransacetylase, or butyrate kinase) or in a high-solvent-producing strain (mutant B). This result is in agreement with the previous findings of a similar degradation rate in a degenerate strain (M5) that had lost the ability to produce solvent. A series of antisense constructs were made that reduced the expression of hydA, encoding the Fe-hydrogenase, or hydE and hydF, genes encoding hydrogenase maturating proteins. While the antisense hydA strain had only similar to 30 % of the activity of wild type, the antisense hydE strain exhibited a TNT degradation rate around 70 % that of the parent. Overexpression of hydA modestly increased the TNT degradation rate in acid phase cells, suggesting the amount of reductant flowing into hydrogenase rather than the hydrogenase level itself was a limiting factor in many situations. The redox potential, hydrogen evolution, and organic acid metabolites produced during rapid TNT transformation in early log phase cultures were measured. The redox potential of the acid-producing culture decreased from -370 to -200 mV immediately after addition of TNT and the hydrogen evolution rate decreased, lowering the hydrogen to carbon dioxide ratio from 1.4 to around 1.1 for 15 min. During the time of TNT transformation, the treated acidogenic cells produced less acetate and more butyrate. The results show that during TNT transformation, the cells shift metabolism away from hydrogen formation to reduction of TNT and the resulting effects on cell redox cofactors generate a higher proportion of butyrate.
C1 [Bennett, George N.] Rice Univ, Dept Biochem & Cell Biol, Houston, TX 77005 USA.
[Servinsky, Matthew; Kiel, James; Sund, Christian] USA, Res Lab, Adelphi, MD 20783 USA.
RP Bennett, GN (reprint author), Rice Univ, Dept Biochem & Cell Biol, MS 140,6100 Main St, Houston, TX 77005 USA.
EM xpcaimail@gmail.com; gbennett@rice.edu
FU Army Research Office [W911NF0910119]
FX This project was supported by the Army Research Office, grant number
W911NF0910119. Also, we would like to thank Mary Harrison and David
French for assistance with this research and data management.
NR 38
TC 3
Z9 3
U1 1
U2 26
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0175-7598
J9 APPL MICROBIOL BIOT
JI Appl. Microbiol. Biotechnol.
PD MAY
PY 2013
VL 97
IS 10
BP 4651
EP 4663
DI 10.1007/s00253-012-4253-3
PG 13
WC Biotechnology & Applied Microbiology
SC Biotechnology & Applied Microbiology
GA 141HQ
UT WOS:000318716700039
PM 22843424
ER
PT J
AU Cole, RE
Boyer, KM
Spanbauer, SM
Sprague, D
Bingham, M
AF Cole, Renee E.
Boyer, Kathleen M.
Spanbauer, Sean M.
Sprague, Denise
Bingham, Mona
TI Effectiveness of Prediabetes Nutrition Shared Medical Appointments
Prevention of Diabetes
SO DIABETES EDUCATOR
LA English
DT Article
ID IMPAIRED GLUCOSE-TOLERANCE; PRIMARY-CARE; WEIGHT-LOSS;
COST-EFFECTIVENESS; HEART-FAILURE; MANAGEMENT; INTERVENTIONS; ADULTS;
MULTIDISCIPLINARY; POPULATION
AB Purpose
The purpose of this study is to evaluate the effectiveness of a nutrition-based shared medical appointment (SMA) intervention in the treatment of prediabetes compared to the individualized counseling standard of care.
Methods
A randomized controlled trial design comparing health outcomes in patients with prediabetes attending either an individualized counseling (control group) or three 90-minute nutrition SMA (intervention group) sessions. Demographic, anthropometric (weight and body mass index), clinical (blood pressure), and biochemical (lipid profile, fasting blood sugar, glycated hemoglobin, albumin- to-creatinine ratio) measures were obtained from all participants at baseline, at 3 months, and at 1 year.
Results
Ninety-four participants were randomized into the 2 study groups with a 69% completion rate at 1 year (n = 34 SMA, n = 31 control). The average participant was Caucasian (64%), male (54%), 58.3 +/- 9.6 years, had a BMI of 30.8 +/- 4.9 kg/m(2) (obese), and fasting blood glucose of 109 +/- 9.5 mg/dL. The SMA and control participants lost a mean of 6.6 pounds and 3.6 pound, respectively; neither group met the 5% modest weight loss expected. The SMA and control group experienced a mean drop in fasting blood glucose of 6 mg/dL.
Conclusions
As demands on health care providers continue to rise, finding innovative ways to manage the patient load while providing quality health care is increasingly important. SMA health outcomes were equivalent to individual counseling outcomes, while increasing the provider's productivity by treating 6 to 8 people with prediabetes in 90 minutes compared to 1 patient in 60 minutes.
C1 [Cole, Renee E.; Spanbauer, Sean M.] USA, Med Dept Ctr & Sch, Joint Base San Antonio F, TX 78234 USA.
[Boyer, Kathleen M.; Sprague, Denise] San Antonio Mil Med Ctr, Brooke Army Med Ctr, Joint Base San Antonio F, TX USA.
[Bingham, Mona] Samueli Inst, Alexandria, VA USA.
RP Cole, RE (reprint author), USA, Med Dept Ctr & Sch, 3599 Winfield Scott Ave, Joint Base San Antonio F, TX 78234 USA.
EM renee.e.cole.mil@mail.mil
FU Brooke Army Medical Center Department of Pathology
FX Biochemical indices assessment was funded by Brooke Army Medical Center
Department of Pathology.
NR 31
TC 7
Z9 8
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0145-7217
J9 DIABETES EDUCATOR
JI Diabetes Educ.
PD MAY-JUN
PY 2013
VL 39
IS 3
BP 344
EP 353
DI 10.1177/0145721713484812
PG 10
WC Endocrinology & Metabolism; Public, Environmental & Occupational Health
SC Endocrinology & Metabolism; Public, Environmental & Occupational Health
GA 148DR
UT WOS:000319223600007
PM 23589326
ER
PT J
AU Clark, P
Rooks, VJ
Lustik, M
AF Clark, Paul
Rooks, Veronica J.
Lustik, Michael
TI Fast Whole-Body Magnetic Resonance Imaging of Healthy, Term Neonates:
Spectrum of Incidental and Birth-Related Findings
SO JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
LA English
DT Article
DE fast WB-MRI; neonate; normal postpartum; fascial fluid
ID CHILDREN; MRI
AB Purpose: The objective of this study was to describe normal postpartum findings seen with fast whole-body magnetic resonance imaging of healthy, term neonates.
Method: We prospectively analyzed whole-body 3.0-T magnetic resonance imaging of 53 normal neonates scanned within 72 hours of birth to assess for postpartum-related findings.
Results: Increased T2 signal within the subcutaneous and fascial tissues was the most common finding. This pattern was seen in 73.5% of neonates, within 32% of the upper extremities and 62% of the lower extremities. Additional patterns of increased T2 signal were seen in the cervical region, joint spaces, groin, and axilla. Several of these patterns were more common in larger infants. No significant differences were seen between vaginal and cesarean deliveries.
Conclusions: The presence of fascial fluid as demonstrated with whole-body magnetic resonance imaging is considered a normal finding in postpartum neonates, likely related to the birthing process of labor and not an indication of underlying pathology.
C1 [Clark, Paul] Ft Belvoir Community Hosp, Ft Belvoir, VA 22060 USA.
[Rooks, Veronica J.; Lustik, Michael] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
RP Clark, P (reprint author), Ft Belvoir Community Hosp, 9300 DeWitt Loop, Ft Belvoir, VA 22060 USA.
EM critoes@gmail.com
NR 11
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0363-8715
J9 J COMPUT ASSIST TOMO
JI J. Comput. Assist. Tomogr.
PD MAY-JUN
PY 2013
VL 37
IS 3
BP 371
EP 376
DI 10.1097/RCT.0b013e3182867bc2
PG 6
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA 146UA
UT WOS:000319116700009
PM 23674007
ER
PT J
AU Bier, SA
Hermstad, E
Trollman, C
Holt, M
AF Bier, Scott A.
Hermstad, Erik
Trollman, Christopher
Holt, Melinda
TI ARMY FLIGHT MEDIC PERFORMANCE OF PARAMEDIC LEVEL PROCEDURES: INDICATED
VS. PERFORMED
SO JOURNAL OF EMERGENCY MEDICINE
LA English
DT Article
DE military medicine; emergency medical services; air ambulance
ID MEDEVAC
AB Background: There is great disparity in the education, experience, and staffing requirements for civilian and Army aeromedical transports (AMT). Objective: This study sought to determine if medical skills beyond the standard training for Army flight medics were indicated and being performed on Army AMT missions. As a secondary measure, the percentage of indicated interventions performed by basic Emergency Medical Technician (EMT-B) and paramedic (EMT-P) flight medics were compared. Methods: This was a retrospective review of Army AMT charts including patients transported by an EMT-B-staffed unit in Iraq and an EMT-P-staffed unit in Afghanistan from July 2008 to June 2009. Charts were reviewed independently by two Emergency Medicine board-certified Army flight surgeons. Results: Of 984 interventions found to be indicated on the 406 charts that met inclusion criteria, 36% were rated as EMT-P level. Seventeen percent were indicated but not performed. EMT-Bs failed to perform indicated procedures 35% of the time vs. 3% in the EMT-P group (p < 0.001). For paramedic-level procedures, EMTBs failed to make 76% of appropriate interventions, compared to < 1% in the EMT-P group (p < 0.001). Conclusions: There seems to be a substantial number of procedures beyond the scope of standard Army flight medic training being required for Army AMT missions. It seems that when advance interventions are indicated, those trained to the EMT-P level perform them significantly more often than those trained to Army standard. Conclusions: Based on the findings of this study, the authors suggest the Army consider adopting the standards required for civilian AMT. Published by Elsevier Inc.
C1 [Bier, Scott A.] USA, Med Corps, Dept Emergency Med, Ft Hood, TX 77380 USA.
[Hermstad, Erik] USA, Med Corps, Dept Emergency Med, William Beaumont Army Med Ctr, Ft Bliss, TX USA.
[Trollman, Christopher] USA, Med Corps, Ft Campbell, KY USA.
[Holt, Melinda] Sam Houston State Univ, Dept Math & Stat, Huntsville, TX 77340 USA.
RP Bier, SA (reprint author), USA, Med Corps, Dept Emergency Med, 4th Combat Aviat Brigade, Ft Hood, TX 77380 USA.
NR 10
TC 0
Z9 0
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0736-4679
J9 J EMERG MED
JI J. Emerg. Med.
PD MAY
PY 2013
VL 44
IS 5
BP 962
EP 969
DI 10.1016/j.jemermed.2012.11.006
PG 8
WC Emergency Medicine
SC Emergency Medicine
GA 144CC
UT WOS:000318916200020
PM 23351570
ER
PT J
AU Benton, CG
West, MW
Hall, SM
Marko, ST
Johnson, JC
AF Benton, Carrie G.
West, Michael W.
Hall, Shane M.
Marko, Shannon T.
Johnson, Joshua C.
TI Effect of Short-Term Pair Housing of Juvenile Rhesus Macaques (Macaca
mulatta) on Immunologic Parameters
SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
LA English
DT Article
ID MEDIATED IMMUNE-RESPONSES; ENVIRONMENTAL ENRICHMENT; CYNOMOLGUS MONKEYS;
FEMALE RHESUS; BEHAVIOR; VIRUS; CYTOKINES; KETAMINE; CELLS; EBOLA
AB Social housing of nonhuman primates (NHP) in an infectious disease setting presents unique challenges, and individual housing is often scientifically justified. At our institute, we recognized an opportunity to limit individual housing to the minimal period necessary by pair-housing NHP after quarantine and separating them just before they are moved into holding rooms for infectious disease studies. To alleviate concerns that pair-housing followed by separation affects the immune system of NHP and makes them unfit as research candidates, we designed a short-term pair-housing study. After a 3-wk baseline period, juvenile rhesus macaques (age, 3 to 4 y) were paired for 7 wk and then separated for 7 wk. During the study, serum cortisol, lymphocyte subsets, and proinflammatory cytokines were measured. The average values for all parameters were significantly lower after separation than during the baseline period. We conclude that short-term pair housing is a viable option at our institute for social housing of NHP.
C1 [Benton, Carrie G.; Marko, Shannon T.] USA, VMD, Med Res Inst Infect Dis, Ft Detrick, MD USA.
[West, Michael W.] USA, Aerobiol Div, Med Res Inst Infect Dis, Ft Detrick, MD USA.
[Johnson, Joshua C.] USA, Div Virol, Med Res Inst Infect Dis, Ft Detrick, MD USA.
[Hall, Shane M.] USA, Publ Hlth Command, Aberdeen, MD USA.
RP Benton, CG (reprint author), USA, VMD, Med Res Inst Infect Dis, Ft Detrick, MD USA.
EM carrie.benton@amedd.army.mil
FU USAMRIID Veterinary Medicine NHP section
FX Opinions, interpretations, conclusions, and recommendations are those of
the authors and are not necessarily endorsed by the US Army or the
Department of Defense. We thank Dr Anna Honk and Dr Rebecca Erwin-Cohen
for help in the design and conduct of the study. In addition, we thank
Stacey Robinson for providing clinical laboratory support, the USAMRIID
Veterinary Medicine NHP section led by SGT Steven Mraz for study
support, and Dr Christine Ege for editorial review.
NR 32
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Z9 2
U1 1
U2 11
PU AMER ASSOC LABORATORY ANIMAL SCIENCE
PI MEMPHIS
PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA
SN 1559-6109
J9 J AM ASSOC LAB ANIM
JI J. Amer. Assoc. Lab. Anim. Sci.
PD MAY
PY 2013
VL 52
IS 3
BP 240
EP 246
PG 7
WC Veterinary Sciences; Zoology
SC Veterinary Sciences; Zoology
GA 146NQ
UT WOS:000319098200003
PM 23849405
ER
PT J
AU Kheirabadi, BS
Terrazas, IB
Hanson, MA
Kragh, JF
Dubick, MA
Blackbourne, LH
AF Kheirabadi, Bijan S.
Terrazas, Irasema B.
Hanson, Margaret A.
Kragh, John F., Jr.
Dubick, Michael A.
Blackbourne, Lorne H.
TI In vivo assessment of the Combat Ready Clamp to control junctional
hemorrhage in swine
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article
DE Combat Ready Clamp; junctional bleeding; hemorrhage control; swine
ID IRAQI INSURGENCY; MODEL; SURVIVAL; INJURIES; EFFICACY
AB BACKGROUND: Junctional wounds and associated hemorrhage have become more common and more lethal in the current war. The Combat Ready Clamp (CRoC) has been developed and deployed for treating junctional hemorrhage on the battlefield. This study examined the efficacy of CRoC and its acute effects in an animal model.
METHODS: Anesthetized pigs (n = 6) were subjected to laparotomy, splenectomy, and abdominal closure. Next, coagulopathy was induced in animals by hemodilution and hypothermia. The left femoral artery was isolated, punctured (6-mm hole), and allowed to bleed for 15 seconds. The groin wound was packed with gauze, and a CRoC applied and tightened until hemorrhage stopped. It was kept in place for 1 hour (treatment period) and then released for another hour or less (control-period) if animal exsanguinated. Fluid resuscitation was administered, and vascular blood flow was examined by Doppler and CT scans. After death, local tissues were collected for histology.
RESULTS: CRoC generated 800 to 900 mm Hg pressure on the wounds, which stopped the hemorrhage and prevented rebleeding during the first hour in all animals. Blood loss was minimal (<= 137 mL), and mean arterial pressure remained at or higher than the target level (65 mm Hg) during this period. Removal of the clamp promptly led to rebleeding and exsanguination of five of six pigs during the second hour despite fluid resuscitation. Blood loss, survival, shock indices, and other measures were significantly (p < 0.01) different between the two periods. Doppler tests and CT scans showed no blood flow in the proximal, distal, and collateral arteries of the clamped leg. Minor inflammation was seen on blood vessels (endothelium) and nerves.
CONCLUSION: CRoC functioned as an effective hemostatic adjunct for compression and control of groin hemorrhage. Although no acute histological damages were seen in compressed tissues, the short-and long-term effects of CRoC application (e.g., total ischemia) on limb function remain unknown and warrant investigation.
C1 [Kheirabadi, Bijan S.; Terrazas, Irasema B.; Hanson, Margaret A.; Kragh, John F., Jr.; Dubick, Michael A.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Kheirabadi, BS (reprint author), 3650 Chambers Pass,BHT2,Bldg 3610, Ft Sam Houston, TX 78234 USA.
EM bijan.kheirabadi@amedd.army.mil
FU US Army Medical Research and Materiel Command and Defense Health Program
[201105]
FX The authors have no conflict of interest to report. This article is not
an endorsement of the CRoC by the authors or the US Army but is simply a
report of our observations with experimental use of the device. The
funding for this work was provided by the US Army Medical Research and
Materiel Command and Defense Health Program (proposal 201105). The
opinions or assertions expressed herein are the private views of the
authors and are not to be construed as official or as reflecting the
views of the US Department of Defense.
NR 21
TC 14
Z9 15
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 2163-0755
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD MAY
PY 2013
VL 74
IS 5
BP 1260
EP 1265
DI 10.1097/TA.0b013e31828cc983
PG 6
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA 149JZ
UT WOS:000319316600018
PM 23609276
ER
PT J
AU Pollard, KA
Gottesman, BL
Rochette, LM
Smith, GA
AF Pollard, Katherine A.
Gottesman, Bethany L.
Rochette, Lynne M.
Smith, Gary A.
TI Swimming injuries treated in US EDs: 1990 to 2008
SO AMERICAN JOURNAL OF EMERGENCY MEDICINE
LA English
DT Article
ID PEDIATRIC SUBMERSION-INJURY; UNITED-STATES; RISK-FACTORS; POOLS;
CHILDHOOD; EXERCISE; ASSOCIATION; PREVENTION; ETIOLOGY
AB Objective: Swimming is one of the most popular recreational activities in the United States. The objective of this study was to investigate the epidemiology of the complete spectrum of injuries associated with swimming and swimming pools treated in US hospital emergency departments.
Methods: Data from the National Electronic Injury Surveillance System from 1990 to 2008 were analyzed. Injury rates were calculated using US census swimming participation data.
Results: An estimated 1688924 swimming injuries occurred during the 19-year study, averaging 1 injury every 6 minutes. During the study period, the number of injuries and rate of injury among individuals 7 years or older significantly increased. Within this trend, injuries peaked in 1999 and significantly decreased during the last 10 years but still showed an overall increase of 18.6% in number and 29.3% in rate from 1900 to 2008. Patients 17 years or younger accounted for 60.5% of injuries, and patients 7 to 17 years of age had a greater mean annual swimming injury rate (18.78 per 10000 participants) than patients older than 17 years (9.15). Most injuries occurred in or around a swimming pool (87.0%), and most were soft tissue injuries (54.7%), followed by strains/sprains (16.4%), fractures/dislocations (11.3%), and submersion (4.9%). Injuries to patients younger than 7 years, submersion injuries, and injuries occurring at home were more likely to result in hospital admission or fatality.
Conclusions: The observed increase in injuries among individuals older than 7 years underscores the need for increased prevention efforts, including education about safe swimming practices, supervision, and environmental modifications. (c) 2013 Elsevier Inc. All rights reserved.
C1 [Pollard, Katherine A.; Gottesman, Bethany L.; Rochette, Lynne M.; Smith, Gary A.] Nationwide Childrens Hosp, Res Inst, Ctr Injury Res & Policy, Columbus, OH 43205 USA.
[Pollard, Katherine A.; Gottesman, Bethany L.; Smith, Gary A.] Ohio State Univ, Coll Med, Columbus, OH 43210 USA.
[Rochette, Lynne M.] USA, Res Inst Behav & Social Sci, Ft Belvoir, VA USA.
[Smith, Gary A.] Child Injury Prevent Alliance, Columbus, OH USA.
RP Smith, GA (reprint author), Nationwide Childrens Hosp, Res Inst, Ctr Injury Res & Policy, Columbus, OH 43205 USA.
EM gary.smith@nationwidechildrens.org
FU National Center for Injury Prevention and Control at the Centers for
Disease Control and Prevention [1H75CE001491]; Ohio State University
College of Medicine
FX National Center for Injury Prevention and Control at the Centers for
Disease Control and Prevention (grant no. 1H75CE001491) and a medical
student research scholarship from The Ohio State University College of
Medicine, which provided a student research stipend for author KAP while
she worked on this study.; The authors gratefully acknowledge support
from the National Center for Injury Prevention and Control at the
Centers for Disease Control and Prevention (grant no. 1H75CE001491) and
from a medical student research scholarship from The Ohio State
University College of Medicine, which provided a student research
stipend for author KAP while she worked on this study. Opinions
expressed in this article do not necessarily represent those of these
funding organizations or the US Department of the Army. The authors also
wish to acknowledge the significant contributions of Brenda J. Shields,
MS, who would have been a coauthor of this study; however, she lost her
battle with cancer just before completion of the manuscript. We are
indebted to her invaluable scholarly input during this study and
dedicate this article to her.
NR 35
TC 0
Z9 1
U1 0
U2 13
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0735-6757
J9 AM J EMERG MED
JI Am. J. Emerg. Med.
PD MAY
PY 2013
VL 31
IS 5
BP 803
EP 809
DI 10.1016/j.ajem.2013.01.028
PG 7
WC Emergency Medicine
SC Emergency Medicine
GA 144UD
UT WOS:000318965100009
PM 23478109
ER
PT J
AU Kragh, JF
Beebe, DF
O'Neill, ML
Beekley, AC
Dubick, MA
Baer, DG
Blackbourne, LH
AF Kragh, John F., Jr.
Beebe, Dorothy F.
O'Neill, Michelle L.
Beekley, Alec C.
Dubick, Michael A.
Baer, David G.
Blackbourne, Lorne H.
TI Performance improvement in emergency tourniquet use during the Baghdad
surge
SO AMERICAN JOURNAL OF EMERGENCY MEDICINE
LA English
DT Letter
ID MAJOR LIMB TRAUMA
C1 [Kragh, John F., Jr.; Dubick, Michael A.; Baer, David G.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Beebe, Dorothy F.] Landstuhl Reg Med Ctr, Dept Prevent Med, APO, AE 09180 USA.
[O'Neill, Michelle L.] Tripler Army Med Ctr, Dept Nursing, Honolulu, HI 96859 USA.
[Beekley, Alec C.] Jefferson Univ, Dept Surg, Philadelphia, PA 19107 USA.
RP Kragh, JF (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
EM John.kragh1@us.army.mil
NR 7
TC 4
Z9 4
U1 0
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0735-6757
J9 AM J EMERG MED
JI Am. J. Emerg. Med.
PD MAY
PY 2013
VL 31
IS 5
BP 873
EP 875
DI 10.1016/j.ajem.2012.11.030
PG 4
WC Emergency Medicine
SC Emergency Medicine
GA 144UD
UT WOS:000318965100025
PM 23481155
ER
PT J
AU Armistead-Jehle, P
Buican, B
AF Armistead-Jehle, Patrick
Buican, Brett
TI Comparison of Select Advanced Clinical Solutions Embedded Effort
Measures to the Word Memory Test in the Detection of Suboptimal Effort
SO ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
LA English
DT Article
DE Suboptimal effort; Symptom Validity Tests; Word Memory Test; Advanced
Clinical Solutions
ID SYMPTOM VALIDITY TESTS; NEUROPSYCHOLOGICAL TESTS; REPEATABLE BATTERY;
MILITARY SAMPLE; EFFORT INDEX; PERFORMANCE; CLAIMANTS
AB This brief report sought to evaluate the classification statistics of the Advanced Clinical Solutions (ACS) embedded measures of symptom validity in relation to the Word Memory Test (WMT), a well-established standalone measure of effort in a sample of active duty military service members with a history of mild traumatic brain injury. Results demonstrated that relative to the WMT, the ACS embedded measures had adequate specificity, but lacked sensitivity. This result is in agreement with previous studies demonstrating poor sensitivity for embedded effort measures relative to standalone Symptom Validity Tests.
C1 [Armistead-Jehle, Patrick] Munson Army Hlth Ctr, Dept Behav Hlth, Ft Leavenworth, KS 66027 USA.
[Buican, Brett] Ireland Army Community Hosp, Traumat Brain Injury Clin, Ft Knox, KY USA.
RP Armistead-Jehle, P (reprint author), Munson Army Hlth Ctr, Dept Behav Hlth, 550 Pope Ave, Ft Leavenworth, KS 66027 USA.
EM patrick.jehle@amedd.army.mil
NR 27
TC 4
Z9 4
U1 1
U2 8
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0887-6177
J9 ARCH CLIN NEUROPSYCH
JI Arch. Clin. Neuropsychol.
PD MAY
PY 2013
VL 28
IS 3
BP 297
EP 301
DI 10.1093/arclin/act017
PG 5
WC Psychology, Clinical; Psychology
SC Psychology
GA 138YK
UT WOS:000318547600010
PM 23535704
ER
PT J
AU Weber, NS
Larsen, RA
Fisher, JA
Cowan, DN
Gubata, ME
Niebuhr, DW
AF Weber, Natalya S.
Larsen, Rakel A.
Fisher, Jared A.
Cowan, David N.
Gubata, Marlene E.
Niebuhr, David W.
TI Association Between Schizophrenia and Autoimmune Diseases in the
National Hospital Discharge Survey (NHDS)
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 68th Annual Scientific Meeting of the Society-of-Biological-Psychiatry
CY MAY 16-18, 2013
CL San Francisco, CA
SP Soc Biol Psychiat
DE schizophrenia; autoimmune; comorbidity; psoriasis; diabetes
C1 [Weber, Natalya S.; Larsen, Rakel A.; Fisher, Jared A.; Cowan, David N.; Gubata, Marlene E.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Niebuhr, David W.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2013
VL 73
IS 9
SU S
MA 881
BP 282S
EP 282S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 140RE
UT WOS:000318671801191
ER
PT J
AU Zhang, SS
AF Zhang, Sheng S.
TI New insight into liquid electrolyte of rechargeable lithium/sulfur
battery
SO ELECTROCHIMICA ACTA
LA English
DT Article
DE Lithium/sulfur battery; Liquid electrolyte; Polysulfide; Quaternary
ammonium; Ionic liquid
ID CYCLE LIFE CHARACTERISTICS; GLYCOL) DIMETHYL ETHER; SULFUR BATTERY;
IONIC LIQUID; DISCHARGE PERFORMANCE; CELLS; REVERSIBILITY; COMPOSITES;
ANODE; LINO3
AB The lithium/sulfur (Li/S) cell is a liquid electrochemical system, in which the dissolution of lithium polysulfide (PS, the series of the sulfur reduction intermediates) plays an essential role in the cell's performance. In solution, the PS undergo a series of complicated disproportionations, as described by a general equation of Li2Sn -> m/8S(8) + Li2Sn-m, to form the less soluble sulfur and low-order PS, which become inactive once precipitated out of the liquid electrolyte or deposited into the pores of separator. Based on the hard and soft acids and bases (HSAB) theory, quaternary ammonium cations are expected to stabilize the PS anions through a chemical interaction between the soft acid and soft base. In this paper, we report a significant improvement in the capacity retention of a Li/S cell by introducing a tetrabutylammonium triflate (NBu4SO3CF3) or an N-methyl-N-butylpyrrolidinium bis(trifluoromethanesulfonyl)imide (PYR14TFSI) into the liquid electrolyte. For example, by using an electrolyte of 0.25 mol kg(-1) LiNO3-0.25 mol kg(-1) PYR14TFSI dissolved in a 1:1 (wt.) mixture of dimethyl ether (DME) and 1,3-dioxolane (DOL), a Li/S cell with a cathode containing 77% sulfur and a 2 mg cm(-2) sulfur loading exhibited an initial capacity of 1227 mAh g(-1) and retained a capacity of 875 mAh g(-1) after 40 cycles when cycled at 0.2 mA cm(-2) between 1.7V and 2.8 V. We contribute the improved performance to the stabilized PS anions by the added quaternary ammonium cations. Published by Elsevier Ltd.
C1 USA, Electrochem Branch, RDRL SED C, Sensors & Electron Devices Directorate,Res Lab, Adelphi, MD 20783 USA.
RP Zhang, SS (reprint author), USA, Electrochem Branch, RDRL SED C, Sensors & Electron Devices Directorate,Res Lab, Adelphi, MD 20783 USA.
EM shengshui.zhang.civ@mail.mil
RI Zhang, Sheng/A-4456-2012
OI Zhang, Sheng/0000-0003-4435-4110
NR 29
TC 44
Z9 47
U1 12
U2 238
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0013-4686
J9 ELECTROCHIM ACTA
JI Electrochim. Acta
PD MAY 1
PY 2013
VL 97
BP 226
EP 230
DI 10.1016/j.electacta.2013.02.122
PG 5
WC Electrochemistry
SC Electrochemistry
GA 145NU
UT WOS:000319024500028
ER
PT J
AU Webb, RP
Smith, LA
AF Webb, Robert P.
Smith, Leonard A.
TI What next for botulism vaccine development?
SO EXPERT REVIEW OF VACCINES
LA English
DT Article
DE botulinum neurotoxin; botulism; mucosal vaccine; subunit vaccine; toxoid
vaccine; viral vaccine
ID CERVICAL DYSTONIA PATIENTS; NEUROTOXIN SEROTYPE-A; HIGH-LEVEL
EXPRESSION; ADENOVIRUS F PROTEIN; DNA REPLICON VACCINE;
CLOSTRIDIUM-BOTULINUM; LIGHT-CHAIN; IMMUNE-RESPONSE; SUBUNIT VACCINE;
HEAVY-CHAIN
AB Botulism is a severe neuroparalytic disease caused by the toxins produced from several Clostridium species. Botulinum neurotoxins (BoNTs) cause flaccid paralysis by inducing a blockade at voluntary motor and autonomic cholinergic junctions that, if not treated, can be fatal. Vaccination to elicit protective circulating antibodies that bind, neutralize and clear toxins before they can be internalized and affect cholinergic neurons remains the most effective form of protection against BoNT. A pentavalent BoNT toxoid vaccine administered in the USA under an Investigational New Drug protocol to at-risk workers was discontinued by the CDC in 2011 due to diminished potency and reactogenic effects. Subsequent research efforts have primarily focused on recombinant protein antigens. This review focuses on the development of a recombinant bivalent vaccine (rBV A/B) composed of purified recombinant BoNT/A and BoNT/B receptor-binding domain proteins, as well as presenting a summary of progress and issues associated with alternative vaccines currently being developed against botulism.
C1 [Webb, Robert P.; Smith, Leonard A.] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
RP Smith, LA (reprint author), USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
EM leonard.a.smith1.civ@army.mil
NR 91
TC 10
Z9 10
U1 0
U2 25
PU EXPERT REVIEWS
PI LONDON
PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB,
ENGLAND
SN 1476-0584
J9 EXPERT REV VACCINES
JI Expert Rev. Vaccines
PD MAY
PY 2013
VL 12
IS 5
BP 481
EP 492
DI 10.1586/ERV.13.37
PG 12
WC Immunology
SC Immunology
GA 143FP
UT WOS:000318852500008
PM 23659297
ER
PT J
AU Grujicic, M
Ramaswami, S
Snipes, JS
Yavari, R
Arakere, A
Yen, CF
Cheeseman, BA
AF Grujicic, M.
Ramaswami, S.
Snipes, J. S.
Yavari, R.
Arakere, A.
Yen, C. -F.
Cheeseman, B. A.
TI Computational Modeling of Microstructural-Evolution in AISI 1005 Steel
During Gas Metal Arc Butt Welding
SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
LA English
DT Article
DE AISI 1005; finite-element analysis; gas metal arc welding (GMAW);
microstructural-evolution
ID KINETICS; REAUSTENITIZATION; DIFFRACTION; NUCLEATION; PHASES; AA5083;
ALLOY
AB A fully coupled (two-way), transient, thermal-mechanical finite-element procedure is developed to model conventional gas metal arc welding (GMAW) butt-joining process. Two-way thermal-mechanical coupling is achieved by making the mechanical material model of the workpiece and the weld temperature-dependent and by allowing the potential work of plastic deformation resulting from large thermal gradients to be dissipated in the form of heat. To account for the heat losses from the weld into the surroundings, heat transfer effects associated with natural convection and radiation to the environment and thermal-heat conduction to the adjacent workpiece material are considered. The procedure is next combined with the basic physical-metallurgy concepts and principles and applied to a prototypical (plain) low-carbon steel (AISI 1005) to predict the distribution of various crystalline phases within the as-welded material microstructure in different fusion zone and heat-affected zone locations, under given GMAW-process parameters. The results obtained are compared with available open-literature experimental data to provide validation/verification for the proposed GMAW modeling effort.
C1 [Grujicic, M.; Ramaswami, S.; Snipes, J. S.; Yavari, R.; Arakere, A.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA.
[Yen, C. -F.; Cheeseman, B. A.] USA, Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA.
RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovation Bldg, Clemson, SC 29634 USA.
EM gmica@clemson.edu
FU Army Research Office [W911NF-11-1-0207, W911NF-09-1-0513]; US
Army/Clemson University [W911NF-04-2-0024, W911NF-06-2-0042]
FX The material presented in this paper is based on work supported by two
Army Research Office sponsored grants (W911NF-11-1-0207 and
W911NF-09-1-0513) and two US Army/Clemson University Cooperative
Agreements (W911NF-04-2-0024 and W911NF-06-2-0042). The authors are
indebted to Dr. Larry C. Russell, Jr. of ARO for his continuing support
and interest in this study.
NR 38
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U1 0
U2 13
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1059-9495
EI 1544-1024
J9 J MATER ENG PERFORM
JI J. Mater. Eng. Perform.
PD MAY
PY 2013
VL 22
IS 5
BP 1209
EP 1222
DI 10.1007/s11665-012-0402-1
PG 14
WC Materials Science, Multidisciplinary
SC Materials Science
GA 126WL
UT WOS:000317652800001
ER
PT J
AU Brammer, AT
Jordon, JB
Allison, PG
Barkey, ME
AF Brammer, A. T.
Jordon, J. B.
Allison, P. G.
Barkey, M. E.
TI Strain-Controlled Low-Cycle Fatigue Properties of Extruded 6061-T6
Aluminum Alloy
SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
LA English
DT Editorial Material
C1 [Brammer, A. T.; Jordon, J. B.] Univ Alabama, Dept Mech Engn, Tuscaloosa, AL 35487 USA.
[Allison, P. G.] USA, Engn Res & Dev Ctr, Corps Engineers, Vicksburg, MS 39180 USA.
[Barkey, M. E.] Univ Alabama, Dept Aerosp Engn & Mech, Tuscaloosa, AL 35487 USA.
RP Brammer, AT (reprint author), Univ Alabama, Dept Mech Engn, Tuscaloosa, AL 35487 USA.
EM bjordon@eng.ua.edu
OI Allison, Paul/0000-0002-9041-237X
NR 11
TC 3
Z9 3
U1 1
U2 18
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1059-9495
J9 J MATER ENG PERFORM
JI J. Mater. Eng. Perform.
PD MAY
PY 2013
VL 22
IS 5
BP 1348
EP 1350
DI 10.1007/s11665-012-0411-0
PG 3
WC Materials Science, Multidisciplinary
SC Materials Science
GA 126WL
UT WOS:000317652800015
ER
PT J
AU Chong, ST
Kim, HC
Lee, IY
Kollars, TM
Sancho, AR
Sames, WJ
Klein, TA
AF Chong, Sung Tae
Kim, Heung Chul
Lee, In-Yong
Kollars, Thomas M., Jr.
Sancho, Alfredo R.
Sames, William J.
Klein, Terry A.
TI Comparison of Dragging and Sweeping Methods for Collecting Ticks and
Determining Their Seasonal Distributions for Various Habitats, Gyeonggi
Province, Republic of Korea
SO JOURNAL OF MEDICAL ENTOMOLOGY
LA English
DT Article
DE tick; sweeping; dragging; habitats; seasonal prevalence
ID BORNE ENCEPHALITIS-VIRUS; BRIDGES TRAINING AREA; FIRING POINTS 10; SMALL
MAMMALS; HANTAAN VIRUS; LYME-DISEASE; SCRUB TYPHUS; SOUTH-KOREA; DEER
TICK; SURVEILLANCE
AB As part of the 65th Medical Brigade tick-borne disease surveillance program to determine the abundance, geographical and seasonal distributions, and tick-borne pathogens present in the Republic of Korea, dragging and sweeping methods were compared to determine their efficiency for collecting ticks in grass and deciduous, conifer, and mixed forest habitats at military training sites and privately owned lands in northern Gyeonggi Province near the demilitarized zone from April-October, 2004-2005. Three species of Ixodid ticks, Haemaphysalis longicornis, Haemaphysalis flava, and Ixodes nipponensis, were collected. Overall, H. longicornis adults and nymphs were most frequently collected from grass and deciduous forest habitats, accounting for 98.2 and 66.2%, respectively, of all ticks collected. H. flava adults and nymphs were most frequently collected from conifer and mixed forests, accounting for 81.6, and 77.8%, respectively, of all ticks collected. I. nipponensis adults and nymphs accounted for 9.3% of all ticks collected from mixed forests, were less commonly collected from deciduous (4.1%) and conifer (4.1%) forests, and infrequently collected from grass habitats (0.9%). Overall, there were no significant differences between dragging and sweeping methods for the three species when the areas sampled were similar (sweeping = 2 x the area over the same transect). Adults and nymphs of H. longicornis were most commonly collected from April-August, while those of H. flava and I. nipponensis were most commonly collected during April-July and again during October. Larvae of all three species were most frequently observed from July-September.
C1 [Chong, Sung Tae; Kim, Heung Chul] 65 Med Brigade, Med Detachment 5, Multifunct Med Battal 168, Unit 15247, APO, AP 96205 USA.
[Lee, In-Yong] Yonsei Univ, Coll Med, Dept Environm Med Biol, Seoul 120752, South Korea.
[Kollars, Thomas M., Jr.] 415 Chem Brigade, Med Sect, Greenville, SC 29605 USA.
[Sames, William J.] WRAMC Forest Glen Annex, Armed Forces Pest Management Board, Washington, DC 20307 USA.
[Klein, Terry A.] USA, MEDDAC Korea, Unit 15281, APO, AP 96205 USA.
RP Klein, TA (reprint author), USA, MEDDAC Korea, Unit 15281, 65th Med Brigade, APO, AP 96205 USA.
EM terry.klein@us.army.mil
FU AFHSC-GEIS, Silver Spring, MD; National Center for Medical Intelligence,
Ft. Detrick, MD
FX We thank COL Hee-Choon Sam Lee, Chief, Force Health Protection and
Preventive Medicine (FHP&PM), 65th Medical Brigade (MED BDE), for his
dedicated support. We sincerely thank Suk-Hee Yi, FHP&PM, 65th MED BDE,
for providing GIS maps of collection sites and data statistical
analysis. We also thank Joel Gaydos, Armed Forces Health Surveillance
Center-Global Emerging Infections Surveillance and Response System
(AFHSC-GEIS), Silver Spring, MD, for his encouragement and support.
Funding for this work was provided through the joint partnership between
the AFHSC-GEIS, Silver Spring, MD, and the National Center for Medical
Intelligence, Ft. Detrick, MD.
NR 41
TC 10
Z9 10
U1 1
U2 11
PU ENTOMOLOGICAL SOC AMER
PI LANHAM
PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA
SN 0022-2585
J9 J MED ENTOMOL
JI J. Med. Entomol.
PD MAY
PY 2013
VL 50
IS 3
BP 611
EP 618
DI 10.1603/ME12032
PG 8
WC Entomology; Veterinary Sciences
SC Entomology; Veterinary Sciences
GA 146VT
UT WOS:000319123600018
PM 23802457
ER
PT J
AU Kiley, KC
AF Kiley, Kevin C.
TI Unintended Pregnancy Among Active-Duty Women in the United States
Military, 2008 and "Do Ask, Do Provide" Contraception for Women in the
U.S. Military
SO OBSTETRICS AND GYNECOLOGY
LA English
DT Letter
C1 [Kiley, Kevin C.] Albany Med Coll, USA, Albany, NY 12208 USA.
NR 5
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0029-7844
J9 OBSTET GYNECOL
JI Obstet. Gynecol.
PD MAY
PY 2013
VL 121
IS 5
BP 1111
EP 1111
DI 10.1097/AOG.0b013e31828fff7e
PG 1
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 139SU
UT WOS:000318605400035
PM 23635759
ER
PT J
AU DeVine, JG
AF DeVine, John G.
TI Bone grafting techniques in idiopathic scoliosis: a confirmation that
allograft is as good as autograft but dispels the purported pain
associated with the iliac crest bone graft harvest
SO SPINE JOURNAL
LA English
DT Editorial Material
ID SITE MORBIDITY; SPINAL-FUSION; SURGERY; OUTCOMES
C1 Dwight D Eisenhower Army Med Ctr, Dept Orthopaed & Rehabil, Ft Gordon, GA 30905 USA.
RP DeVine, JG (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Orthopaed & Rehabil, 300 E Hosp Rd, Ft Gordon, GA 30905 USA.
EM john-devine@comcast.net
NR 11
TC 2
Z9 4
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1529-9430
J9 SPINE J
JI Spine Journal
PD MAY
PY 2013
VL 13
IS 5
BP 530
EP 531
DI 10.1016/j.spinee.2013.02.047
PG 2
WC Clinical Neurology; Orthopedics
SC Neurosciences & Neurology; Orthopedics
GA 144YI
UT WOS:000318978300013
PM 23664557
ER
PT J
AU Wu, CC
Chung, PW
Aubry, S
Munday, LB
Arsenlis, A
AF Wu, C. -C.
Chung, P. W.
Aubry, S.
Munday, L. B.
Arsenlis, A.
TI The strength of binary junctions in hexagonal close-packed crystals
SO ACTA MATERIALIA
LA English
DT Article
DE Discrete dislocation dynamics; Strength; Yield surface; hcp Metals
ID DISLOCATION JUNCTIONS; FOREST INTERACTIONS; FCC CRYSTALS; SLIP SYSTEMS;
METALS; SIMULATIONS; DYNAMICS; STRESS; MECHANISMS; DENSITY
AB A comparative study of non-coplanar binary dislocation junctions in magnesium (Mg) and beryllium (Be) is presented to examine the effects of elastic properties and active Burgers vectors on junction formation and destruction in hexagonal close-packed (hcp) crystals via discrete dislocation dynamics simulations. Two junction configurations formed at intersecting prismatic (01 (1) over bar0)/basal (0001) planes and type-II pyramidal ((2) over bar 112)/prismatic (01 (1) over bar0) planes are studied using Burgers vectors of varying magnitudes. The equilibrium junctions are created from two intersecting straight gliding dislocations, and their subsequent strengths are evaluated under uniform applied stresses. The relative junction strengths between Mg and Be are consistent with their relative elastic stiffness, i.e., the modulus of elasticity for Mg is approximately one order of magnitude smaller than that of Be, and their junction strengths are similarly one order of magnitude apart. In general, the yield surfaces for junctions in Be are larger than those in Mg after normalization with the respective elastic moduli and Poisson's ratios. All yield surfaces exhibit a strong symmetry. However, the size and shape of the yield surfaces depend on the slip systems, especially the active Burgers vectors. The yield surfaces of hcp crystals can resemble those of face-centered cubic or body-centered cubic crystals when the active Burgers vectors of the dislocations involved in the junction are of type < a >, namely < 11 (2) over bar0 >, and are distinct when Burgers vectors of different types are used: for instance, a type < a + c >, namely 1/3 < 11 (2) over bar(3) over bar >, interacting with a type < a >. It was also found that junctions with more edge part exhibit more elongated yield surfaces than those with more screw part, and slip systems involved with < a > Burgers vectors result in smaller yield surfaces. These results demonstrate that junction strengths for hcp crystals are largely determined by elastic properties and Burgers vectors. The work aims to assess the effects of intrinsic material properties and dislocation slip systems on the strength of different binary dislocation junctions for general hcp structures. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
C1 [Wu, C. -C.; Chung, P. W.; Munday, L. B.] USA, Res Lab, Computat & Informat Sci Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Aubry, S.; Arsenlis, A.] Lawrence Livermore Natl Lab, Condensed Matter & Mat Div, High Performance Computat Mat Sci & Chem Grp, Livermore, CA 94551 USA.
RP Wu, CC (reprint author), USA, Res Lab, Computat & Informat Sci Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM chi-chin.wu.ctr@mail.mil
FU Oak Ridge Affiliated Universities (ORAU) in Maryland [W911QX-04-C-0129];
Army Research Laboratory (ARL) Enterprise for Multiscale Research of
Materials; ARL Director's Research Initiative (DRI); US Department of
Energy by Lawrence Livermore National Laboratory [DE-AC52-07NA27344]
FX This work was conducted through support from the Oak Ridge Affiliated
Universities (ORAU) in Maryland under Contract No. W911QX-04-C-0129 at
the US Army Research Laboratory, the Army Research Laboratory (ARL)
Enterprise for Multiscale Research of Materials and the ARL Director's
Research Initiative (DRI). Computing resources were provided by the
Department of Defense (DoD) High Performance Supercomputing Resource
Center (DSRC). This work was also performed under the auspices of the US
Department of Energy by Lawrence Livermore National Laboratory under
Contract No. DE-AC52-07NA27344. The authors gratefully appreciate many
valuable discussions with colleagues at ARL, including Kenneth A. Jones,
Jaroslaw Knap, Joshua Crone and Kenneth Leiter.
NR 45
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U1 2
U2 25
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1359-6454
J9 ACTA MATER
JI Acta Mater.
PD MAY
PY 2013
VL 61
IS 9
BP 3422
EP 3431
DI 10.1016/j.actamat.2013.02.033
PG 10
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA 138TS
UT WOS:000318533500028
ER
PT J
AU Pennock, S
Kim, D
Mukai, S
Kuhnle, M
Chun, DW
Matsubara, J
Cui, J
Ma, P
Maberley, D
Samad, A
Van Geest, RJ
Oberstein, SL
Schlingemann, RO
Kazlauskas, A
AF Pennock, Steven
Kim, David
Mukai, Shizuo
Kuhnle, Matthew
Chun, Dal W.
Matsubara, Joanne
Cui, Jing
Ma, Patrick
Maberley, David
Samad, Arif
Van Geest, Robert J.
Oberstein, Sarit L.
Schlingemann, Reinier O.
Kazlauskas, Andrius
TI Ranibizumab Is a Potential Prophylaxis for Proliferative
Vitreoretinopathy, a Nonangiogenic Blinding Disease
SO AMERICAN JOURNAL OF PATHOLOGY
LA English
DT Article
ID ENDOTHELIAL GROWTH-FACTOR; RETINAL-DETACHMENT; MACULAR DEGENERATION;
DIABETIC-RETINOPATHY; INTRAVITREAL BEVACIZUMAB; EPIRETINAL MEMBRANES;
SIGNAL-TRANSDUCTION; EXPERIMENTAL-MODEL; FACTOR RECEPTOR; VITREOUS-HUMOR
AB Proliferative vitreoretinopathy (PVR) exemplifies a disease that is difficult to predict, Lacks effective treatment options, and substantially reduces the quality of life of an individual. Surgery to correct a rhegmatogenous retinal detachment fails primarily because of PVR. Likely mediators of PVR are growth factors in vitreous, which stimulate cells within and behind the retina as an inevitable consequence of a breached retina. Three classes of growth factors [vascular endothelial growth factor A (VEGF-A), platelet-derived growth factors (PDGFs), and non-PDGFs (growth factors outside of the PDGF family)] are relevant to PVR pathogenesis because they act on PDGF receptor alpha, which is required for experimental PVR and is associated with this disease in humans. We discovered that ranibizumab (a clinically approved agent that neutralizes VEGF-A) reduced the bioactivity of vitreous from patients and experimental animals with PVR, and protected rabbits from developing disease. The apparent mechanism of ranibizumab action involved derepressing PDGFs, which, at the concentrations present in PVR vitreous, inhibited non-PDGF-mediated activation of PDGF receptor alpha. These predinical findings suggest that available approaches to neutralize VEGF-A are prophylactic for PVR, and that anti-VEGF-based therapies may be effective for managing more than angiogenesis- and edema-driven pathological conditions.
C1 [Pennock, Steven; Kim, David; Mukai, Shizuo; Kazlauskas, Andrius] Harvard Univ, Sch Med, Massachusetts Eye & Ear Infirm, Schepens Eye Res Inst, Boston, MA 02114 USA.
[Pennock, Steven; Kim, David; Mukai, Shizuo; Kazlauskas, Andrius] Harvard Univ, Sch Med, Dept Ophthalmol, Boston, MA 02114 USA.
[Kuhnle, Matthew; Chun, Dal W.] Walter Reed Army Med Ctr, Dept Surg, Ophthalmol Serv, Washington, DC 20307 USA.
[Matsubara, Joanne; Cui, Jing; Ma, Patrick; Maberley, David] Univ British Columbia, Dept Ophthalmol & Visual Sci, Vancouver, BC V5Z 1M9, Canada.
[Samad, Arif] Dalhousie Univ, Dept Ophthalmol & Visual Sci, Halifax, NS, Canada.
[Van Geest, Robert J.; Oberstein, Sarit L.; Schlingemann, Reinier O.] Univ Amsterdam, Acad Med Ctr, Med Retina Unit, NL-1105 AZ Amsterdam, Netherlands.
[Van Geest, Robert J.; Oberstein, Sarit L.; Schlingemann, Reinier O.] Univ Amsterdam, Acad Med Ctr, Dept Ophthalmol, Ocular Angiogenesis Grp, NL-1105 AZ Amsterdam, Netherlands.
RP Kazlauskas, A (reprint author), Harvard Univ, Sch Med, Dept Ophthalmol, Schepens Eye Res Inst,Massachusetts Eye & Ear Inf, 20 Staniford St, Boston, MA 02114 USA.
EM andrius_kazlauskas@meei.harvard.edu
FU Department of Defense [WB1XWH-10-1-0392]; NIH [EY012509]; Canadian
Institutes of Health Research (CIHR); Mukai Fund; CIHR [IAO 77736, MOP
97806]; Massachusetts Eye and Ear Infirmary (Boston)
FX Supported by Department of Defense grant WB1XWH-10-1-0392 and NIH grant
EY012509 (A.K.), a Canadian Institutes of Health Research (CIHR)
fellowship (S.P.), Mukai Fund and Massachusetts Eye and Ear Infirmary
(Boston) gifts (S.M.), and CIHR grants IAO 77736 and MOP 97806 (J.M. and
J.C.).
NR 62
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Z9 15
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9440
J9 AM J PATHOL
JI Am. J. Pathol.
PD MAY
PY 2013
VL 182
IS 5
BP 1659
EP 1670
DI 10.1016/j.ajpath.2013.01.052
PG 12
WC Pathology
SC Pathology
GA 138TY
UT WOS:000318534100021
PM 23582767
ER
PT J
AU McKinney, C
Elfendahl, M
McMaster, HR
AF McKinney, Chris
Elfendahl, Mark
McMaster, H. R.
TI Why the US Army Needs Armor The Case for a Balanced Force
SO FOREIGN AFFAIRS
LA English
DT Article
C1 [McKinney, Chris; Elfendahl, Mark; McMaster, H. R.] USA, Washington, DC 20310 USA.
[Elfendahl, Mark] Joint Adv Warfighting Sch, Norfolk, VA USA.
[McMaster, H. R.] Maneuver Ctr Excellence, Ft Benning, GA USA.
RP McKinney, C (reprint author), USA, Washington, DC 20310 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU COUNCIL FOREIGN RELAT IONS INC
PI NEW YORK
PA HAROLD PRATT HOUSE, 58 E 68TH ST, NEW YORK, NY 10065 USA
SN 0015-7120
J9 FOREIGN AFF
JI Foreign Aff.
PD MAY-JUN
PY 2013
VL 92
IS 3
BP 129
EP 136
PG 8
WC International Relations
SC International Relations
GA 145NP
UT WOS:000319024000013
ER
PT J
AU Smits, KM
Cihan, A
Sakaki, T
Howington, SE
Peters, JF
Illangasekare, TH
AF Smits, Kathleen M.
Cihan, Abdullah
Sakaki, Toshihiro
Howington, Stacy E.
Peters, John F.
Illangasekare, Tissa H.
TI Soil Moisture and Thermal Behavior in the Vicinity of Buried Objects
Affecting Remote Sensing Detection: Experimental and Modeling
Investigation
SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
LA English
DT Article
DE Environmental factors; geoscience and remote sensing; land surface;
landmine detection; soil moisture
ID IN-FIELD SOILS; LANDMINE DETECTION; WATER-CONTENT; DIURNAL CYCLE; BARE
SOILS; MINES; TEMPERATURE; CONDUCTIVITY; SIGNATURES; DISTRIBUTIONS
AB Improvements in buried mine detection using remote sensing technology rest on understanding the effects on sensor response of spatial and temporal variability created by soil and environmental conditions. However, research efforts on mine detection have generally emphasized sensor development, while less effort has been made to evaluate the effects of the environmental conditions in which the mines are placed. If the processes governing moisture and temperature distribution near the ground surface can be captured, sensor development and deployment can be more realistically tailored to particular operational scenarios and technologies. The objective of this study is to investigate the effects of the soil environment on landmine detection by studying the influence of the thermal boundary conditions at the land-atmosphere interface and the buried objects themselves on the spatial and temporal distribution of soil moisture around shallow-buried objects. Two separate large tank experiments were performed with buried objects with different thermal properties. Experimental results were compared to results from a fully coupled heat and mass transfer numerical model. Comparison of experimental and numerical results suggests that the vapor enhancement factor used to adjust the vapor diffusive flux described based on Fick's law is not necessary under dry soil conditions. Data and simulations from this study show that the thermal signature of a buried object depends on the complex interaction among a soil's water content and its thermal and hydraulic properties. Simulated thermal and saturation contrasts were generally very different for a buried landmine than for other buried objects.
C1 [Smits, Kathleen M.; Sakaki, Toshihiro; Illangasekare, Tissa H.] Colorado Sch Mines, Ctr Expt Study Subsurface Environm Proc, Golden, CO 80401 USA.
[Cihan, Abdullah] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Earth Sci, Berkeley, CA 94720 USA.
[Howington, Stacy E.; Peters, John F.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Smits, KM (reprint author), Colorado Sch Mines, Ctr Expt Study Subsurface Environm Proc, Golden, CO 80401 USA.
RI Smits, Kathleen/F-8465-2014; Cihan, Abdullah/D-3704-2015
FU U. S. Army Research Office [W911NF-04-1-0169]; Engineering Research and
Development Center; Army Research Office
FX This work was supported by the U. S. Army Research Office under Award
W911NF-04-1-0169 and the Engineering Research and Development Center.;
The authors acknowledge R. Harmon from the Army Research Office for
financial support and technical contributions.
NR 64
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U1 1
U2 32
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0196-2892
J9 IEEE T GEOSCI REMOTE
JI IEEE Trans. Geosci. Remote Sensing
PD MAY
PY 2013
VL 51
IS 5
BP 2675
EP 2688
DI 10.1109/TGRS.2012.2214485
PN 1
PG 14
WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote
Sensing; Imaging Science & Photographic Technology
SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science
& Photographic Technology
GA 137IJ
UT WOS:000318428700016
ER
PT J
AU Rose, R
Kheirabadi, BS
Klemcke, HG
AF Rose, Rajiv
Kheirabadi, Bijan S.
Klemcke, Harold G.
TI Arterial blood gases, electrolytes, and metabolic indices associated
with hemorrhagic shock: inter- and intrainbred rat strain variation
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE intrainbred strain variation; intraclass correlation coefficient;
hemorrhage; arterial blood gases; Pa-CO2; oxygen content; blood
electrolytes
ID OXYGEN-TRANSPORT RESPONSES; ACID-BASE; TISSUE HYPOXIA;
MYOCARDIAL-ISCHEMIA; TRAUMA PATIENTS; SURVIVAL-TIME; GLUCOSE; POTASSIUM;
PLASMA; DEATH
AB We have previously shown interstrain variation (indicating a genetic basis), and intrastrain variation in survival time after hemorrhage (STaH) among inbred rat strains. To assist in understanding physiological mechanisms associated with STaH, we analyzed various arterial blood measures (ABM; pH, Pa-CO2, oxygen content, sodium, potassium, glucose, bicarbonate, base excess, total CO2, and ionized calcium) in inbred rats. Rats from five inbred strains (n = 8-10/strain) were catheterized and, similar to 24 h later, subjected to a conscious, controlled, 47% hemorrhage. ABM were measured at the start (initial) and end (final) of hemorrhage. Inter- and intrainbred strain variations of ABM were quantified and compared, and correlations of ABM with STaH were determined. All final ABM values and some initial ABM values were different among strains. Most ABM changed (Delta) during hemorrhage, and these changes differed among strains (P <0.03). Some strain-dependent correlations (r >= 0.7; P <= 0.05) existed between Delta ABM and STaH (e.g., BN/Mcwi, Delta K+, r = -0.84). Dark Agouti rats (longest STaH) had the smallest Delta Pa-CO2, Delta HCO3-, and Delta base excess, and the highest final glucose. High coefficients of variation (CVs, > 10%), strain-specific CVs, and low intraclass correlation coefficients (r(I) < 0.5) defined the large intrastrain ABM variation that exceeded interstrain variation for most ABM. These results suggest that some ABM (K+, Pa-CO2, glucose, oxygen content) could predict subsequent STaH in an inbred rat strain-dependent manner. We speculate that whereas genetic differences may be responsible for interstrain variation, individual-specific epigenetic processes (e. g., DNA methylation) may be partly responsible for both inter- and intrastrain ABM variation.
C1 [Rose, Rajiv; Kheirabadi, Bijan S.; Klemcke, Harold G.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Klemcke, HG (reprint author), USA, Inst Surg Res, 3650 Chamber Pass, Ft Sam Houston, TX 78234 USA.
EM harold.klemcke@amedd.army.mil
FU U.S. Army Medical Research and Materiel Command
FX Support for this study was provided by the U.S. Army Medical Research
and Materiel Command.
NR 80
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U1 0
U2 0
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 8750-7587
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD MAY
PY 2013
VL 114
IS 9
BP 1165
EP 1173
DI 10.1152/japplphysiol.01293.2012
PG 9
WC Physiology; Sport Sciences
SC Physiology; Sport Sciences
GA 138YG
UT WOS:000318547200006
PM 23471949
ER
PT J
AU Stewart, IJ
Cotant, CL
Tilley, MA
Huzar, TF
Aden, JK
Snow, BD
Gisler, C
Kramer, KW
Sherratt, JR
Murray, CK
Blackbourne, LH
Renz, EM
Chung, KK
AF Stewart, Ian J.
Cotant, Casey L.
Tilley, Molly A.
Huzar, Todd F.
Aden, James K.
Snow, Brian D.
Gisler, Christopher
Kramer, Keith W.
Sherratt, Jesse R.
Murray, Clinton K.
Blackbourne, Lorne H.
Renz, Evan M.
Chung, Kevin K.
TI Association of Rhabdomyolysis With Renal Outcomes and Mortality in Burn
Patients
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID ACUTE KIDNEY INJURY; INTENSIVE-CARE-UNIT; RIFLE CRITERIA; FAILURE;
SEVERITY; THERAPY; FLUID
AB The contribution of rhabdomyolysis to acute kidney injury (AKI) in the context of burn injury is poorly studied. We sought to determine the impact of rhabdomyolysis on AKI (defined by the AKI Network classification), renal replacement therapy (RRT), and death. Patients admitted to the burn unit at our institution were examined. Information on sex, age, presence of inhalation injury, electrical burn, percentage TBSA burned, percentage of full-thickness burns, Injury Severity Score, and peak creatine kinase (CK) were recorded. These variables were examined via multivariate logistic regression analysis against AKI Network stage, RRT, and death. Of 1973 consecutive admissions meeting the inclusion criteria, 525 met our eligibility criteria. Log peak CK was found to be correlated with any stage of AKI (odds ratio [OR], 1.71; 95% confidence interval [CI], 1.36-2.16; P < .0001), moderate to severe AKI (OR, 2.09; 95% CI, 1.40-3.11; P = .0003), need for RRT (OR, 1.67; 95% CI, 1.16-2.40; P = .0057), and mortality (OR, 1.49; 95% CI, 1.01-2.20; P = .0441), after adjustment. Each 10-fold increase in peak CK was associated with a 70% increase in the odds of AKI, more than a 100% increase in the odds of moderate to severe AKI, a nearly 70% increase in the odds of RRT, and an almost 50% increase in the odds of mortality in patients with burn injury. (J Burn Care Res 2013;34:318-325)
C1 [Stewart, Ian J.; Tilley, Molly A.; Snow, Brian D.; Kramer, Keith W.; Sherratt, Jesse R.; Murray, Clinton K.] San Antonio Mil Med Ctr, Dept Med, Ft Sam Houston, TX USA.
[Huzar, Todd F.] Univ Texas Hlth Sci Ctr Houston, Dept Surg, Houston, TX USA.
[Aden, James K.; Blackbourne, Lorne H.; Renz, Evan M.; Chung, Kevin K.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Gisler, Christopher] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX USA.
[Renz, Evan M.; Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
RP Stewart, IJ (reprint author), ATTN Nephrol, San Antonio Mil Med Ctr, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
FU Department of Defense
FX Supported by the Department of Defense.
NR 30
TC 7
Z9 7
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1559-047X
J9 J BURN CARE RES
JI J. Burn Care Res.
PD MAY-JUN
PY 2013
VL 34
IS 3
BP 318
EP 325
DI 10.1097/BCR.0b013e31825addbd
PG 8
WC Emergency Medicine; Dermatology; Surgery
SC Emergency Medicine; Dermatology; Surgery
GA 139XO
UT WOS:000318618600017
PM 22955163
ER
PT J
AU Poda, AR
Kennedy, AJ
Cuddy, MF
Bednar, AJ
AF Poda, Aimee R.
Kennedy, Alan J.
Cuddy, Michael F.
Bednar, Anthony J.
TI Investigations of UV photolysis of PVP-capped silver nanoparticles in
the presence and absence of dissolved organic carbon
SO JOURNAL OF NANOPARTICLE RESEARCH
LA English
DT Article
DE Silver nanoparticles; Photolysis; Daphnia magna; Field flow
fractionation; FFF-ICP-MS; Dissolved organic carbon; Toxicity;
Environmental relevance
ID ION-RELEASE KINETICS; ANTIBACTERIAL ACTIVITY; METALLIC NANOPARTICLES;
ENVIRONMENTAL FATE; TOXICITY; WATER; MATTER; NANOMATERIALS; DISSOLUTION;
EXPOSURE
AB This study investigated the effect of UV irradiation on the characteristics and toxicity of 50 nm (nominal diameter) polyvinylpyrrolidone-capped silver nanoparticles (AgNPs) in the presence and absence of dissolved organic carbon (DOC). The photolysis resulted in a decrease in average particle size as measured by field flow fractionation interfaced with inductively coupled plasma mass spectrometry. The decrease in size was attributed to the photo-induced oxidation of the PVP and dissolution of metallic silver. Moreover, photolysis of the AgNPs in solutions containing DOC appeared to give rise to small nanoparticles (similar to 5 nm) formed via reduction of dissolved silver ions. These results were consistent with photolysis of AgNO3 solutions initially devoid of nanoparticles. Thus, the carbon-containing constituents of DOC serve as reducing agents for Ag+, primarily under conditions of UV irradiation. The standard zooplankton model, Daphnia magna, indicated that the toxicity of nanosilver was significantly reduced when the AgNPs have been exposed to UV light. Observed toxicity was further reduced when AgNPs in DOC-containing solutions were exposed to UV. These results suggest that environmentally relevant conditions such as DOC and UV light are important mitigating factors that mediate the aquatic toxicity of AgNPs.
C1 [Poda, Aimee R.; Kennedy, Alan J.; Cuddy, Michael F.; Bednar, Anthony J.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
RP Cuddy, MF (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM aimee.r.poda@usace.army.mil; michael.cuddy@usace.army.mil
RI Poda, Aimee/K-1905-2012
NR 34
TC 9
Z9 9
U1 2
U2 88
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1388-0764
J9 J NANOPART RES
JI J. Nanopart. Res.
PD MAY
PY 2013
VL 15
IS 5
AR 1673
DI 10.1007/s11051-013-1673-7
PG 10
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
Science, Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA 139BC
UT WOS:000318555400071
ER
PT J
AU Swearingen, ME
White, MJ
Guertin, PJ
Albert, DG
Tunick, A
AF Swearingen, Michelle E.
White, Michael J.
Guertin, Patrick J.
Albert, Donald G.
Tunick, Arnold
TI Influence of a forest edge on acoustical propagation: Experimental
results
SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
LA English
DT Article
ID IMPEDANCE MODELS; TREE BELTS; SOUND; ATTENUATION; PREDICT
AB Acoustic propagation through a forest edge can produce complicated pressure time histories because of scattering from the trees and changes in the microclimate and ground parameters of the two regions. To better understand these effects, a field experiment was conducted to measure low-frequency acoustic pulses propagating in an open field, a forest, and passing through a forest edge in both directions. Waveforms measured in the open field were simple impulses with very low scattering, whereas waveforms at the edge and within the forest had stronger reverberations after the direct arrival. The direct wave pulse shapes increased in duration in accordance with the path length in the forest, which had an effective flow resistivity 1/2 to 1/3 that of the grassy open field. The measurements exhibit different rates of attenuation in the two regions, with relatively lower attenuation in the open field than higher rates in the forest. Decay of SEL transmitted into the forest was 4 dB more per tenfold distance than for outbound transmission. Stronger attenuation in the 1-2 kHz range occurs when propagating into the forest. While the measured meteorological profiles revealed three distinct micro-climates, meteorological effects are not sufficient to explain the apparent non-reciprocal propagation.
C1 [Swearingen, Michelle E.; White, Michael J.; Guertin, Patrick J.] USA, Construct Engn Res Lab, Engineer Res & Dev Ctr, Champaign, IL 61826 USA.
[Albert, Donald G.] USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA.
[Tunick, Arnold] USA, Res Lab, Adelphi, MD 20783 USA.
RP Swearingen, ME (reprint author), USA, Construct Engn Res Lab, Engineer Res & Dev Ctr, Champaign, IL 61826 USA.
EM michelle.e.swearingen@usace.army.mil
FU U.S. Army Engineer Research and Development Center Environmental
Quality/Technology and Installations Basic Research Program [AT23-06-54,
BT25-12-94]
FX The authors would like to thank CPT Keith Ferdon, Bill Brown, Tim Notch,
CW2 Derek Lindberg, SSG Justin Piepenburg, and all of the personnel at
Camp Ripley who provided test support and logistical assistance. The
authors also thank Jeff Mifflin, Steve Decato, and Tim Onder for their
assistance during field data collection. The authors also thank the
anonymous reviewers for their comments. Funding support was provided by
project AT23-06-54 and BT25-12-94, part of the U.S. Army Engineer
Research and Development Center Environmental Quality/Technology and
Installations Basic Research Program. (Distribution Statement A -
Approved for Public Release; distribution unlimited.)
NR 29
TC 3
Z9 3
U1 0
U2 13
PU ACOUSTICAL SOC AMER AMER INST PHYSICS
PI MELVILLE
PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA
SN 0001-4966
J9 J ACOUST SOC AM
JI J. Acoust. Soc. Am.
PD MAY
PY 2013
VL 133
IS 5
BP 2566
EP 2575
DI 10.1121/1.4799011
PN 1
PG 10
WC Acoustics; Audiology & Speech-Language Pathology
SC Acoustics; Audiology & Speech-Language Pathology
GA 139BH
UT WOS:000318555900021
PM 23654365
ER
PT J
AU Nykaza, ET
Hodgdon, KK
Gaugler, T
Krecker, P
Luz, GA
AF Nykaza, Edward T.
Hodgdon, Kathleen K.
Gaugler, Trent
Krecker, Peg
Luz, George A.
TI On the relationship between blast noise complaints and community
annoyance
SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
LA English
DT Article
ID HUMAN RESPONSE; EXPOSURE; MODEL
AB Military installations typically rely on noise complaints to indicate adverse noise environments and often restrict the firing of certain weapons to reduce the number of noise complaints. Using complaints in this manner may also imply that the absence of complaints is an indicator of low community annoyance. The relationship between individual complaints and general community annoyance, however, is currently not established, and it is unknown whether implementing restrictions in reaction to individual complaints is an appropriate or necessary way to reduce community annoyance. This paper looks at whether there are significant differences in reported annoyance to complaint-referenced blast events and general military noise annoyance between those who complain and their non-complaining neighbors. Those who complained were significantly more annoyed to both complaint-referenced blast events and general military noise in comparison to their non-complaining neighbors. The implications of these findings are discussed in terms of range management. [http://dx.doi.org/10.1121/1.4795781]
C1 [Nykaza, Edward T.] USA, Corps Engineers, Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA.
[Hodgdon, Kathleen K.; Gaugler, Trent] Penn State Univ, State Coll, PA 16804 USA.
[Krecker, Peg] Tetra Tech, Madison, WI 53719 USA.
RP Nykaza, ET (reprint author), USA, Corps Engineers, Engn Res & Dev Ctr, Construct Engn Res Lab, POB 9005, Champaign, IL 61826 USA.
EM edward.t.nykaza@erdc.dren.mil
OI Gaugler, Trent/0000-0002-8006-9184
FU Strategic Environmental Research and Development Program (SERDP);
Engineer Research and Development Center (ERDC)
FX This work has been funded by the Strategic Environmental Research and
Development Program (SERDP) and the Engineer Research and Development
Center (ERDC). The authors would like to thank Larry Pater, Sandy
Fidell, and Paul Schomer for their input on the original study design,
and the two anonymous reviewers for their constructive comments. The
opinions expressed in this document are solely those of the authors and
are not to be construed as an official Department of the Army position
unless so designated by other authorized documents. [Distribution
Statement - A (Approved for public release; distribution unlimited)]
NR 46
TC 4
Z9 4
U1 0
U2 4
PU ACOUSTICAL SOC AMER AMER INST PHYSICS
PI MELVILLE
PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA
SN 0001-4966
J9 J ACOUST SOC AM
JI J. Acoust. Soc. Am.
PD MAY
PY 2013
VL 133
IS 5
BP 2690
EP 2698
DI 10.1121/1.4795781
PN 1
PG 9
WC Acoustics; Audiology & Speech-Language Pathology
SC Acoustics; Audiology & Speech-Language Pathology
GA 139BH
UT WOS:000318555900033
PM 23654377
ER
PT J
AU Jang, SG
Audus, DJ
Klinger, D
Krogstad, DV
Kim, BJ
Cameron, A
Kim, SW
Delaney, KT
Hur, SM
Killops, KL
Fredrickson, GH
Kramer, EJ
Hawker, CJ
AF Jang, Se Gyu
Audus, Debra J.
Klinger, Daniel
Krogstad, Daniel V.
Kim, Bumjoon J.
Cameron, Alexandre
Kim, Sang-Woo
Delaney, Kris T.
Hur, Su-Mi
Killops, Kato L.
Fredrickson, Glenn H.
Kramer, Edward J.
Hawker, Craig J.
TI Striped, Ellipsoidal Particles by Controlled Assembly of Diblock
Copolymers
SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Article
ID BLOCK-COPOLYMER; THIN-FILMS; GOLD NANOPARTICLES; MORPHOLOGICAL
TRANSFORMATION; SEPARATED STRUCTURES; SURFACE-CHEMISTRY; POLYMER
PARTICLES; CONFINEMENT; LOCATION; ROUTE
AB Control of interfacial interactions leads to a dramatic change in shape and morphology for particles based on poly(styrene-b-2-vinylpyridine) diblock copolymers Key to these changes is the addition of Au-based surfactant nano particles (SNPs) which are adsorbed at the interface between block copolymer-containing emulsion droplets and the surrounding amphiphilic surfactant to afford asymmetric, ellipsoid particles The mechanism of formation for these novel nanostructures was investigated by systematically varying the volume fraction of SNPs, with the results showing the critical nature that the segregation of SNPs to specific interfaces plays in controlling structure. A theoretical description of the system allows the site distribution and aspect ratio of the asymmetric block copolymer colloidal particles to be correlated with the experimental results.
C1 [Jang, Se Gyu; Audus, Debra J.; Klinger, Daniel; Krogstad, Daniel V.; Cameron, Alexandre; Kim, Sang-Woo; Delaney, Kris T.; Hur, Su-Mi; Fredrickson, Glenn H.; Kramer, Edward J.; Hawker, Craig J.] Univ Calif Santa Barbara, Mat Res Lab, Santa Barbara, CA 93106 USA.
[Audus, Debra J.; Fredrickson, Glenn H.; Kramer, Edward J.] Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA.
[Krogstad, Daniel V.; Fredrickson, Glenn H.; Kramer, Edward J.; Hawker, Craig J.] Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA.
[Hawker, Craig J.] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA.
[Kim, Bumjoon J.] Korea Adv Inst Sci & Technol, Dept Chem & Biomol Engn, Taejon 305701, South Korea.
[Killops, Kato L.] USA, Res Dev & Engn Command, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
RP Fredrickson, GH (reprint author), Univ Calif Santa Barbara, Mat Res Lab, Santa Barbara, CA 93106 USA.
EM ghf@mrl.ucsb.edu; edkramer@mrl.ucsb.edu; hawker@mrl.ucsb.edu
RI Kim, Bumjoon J./C-1714-2011; Delaney, Kris/D-4324-2011
OI Delaney, Kris/0000-0003-0356-1391
FU MRSEC Program of the National Science Foundation (NSF) [DMR-1121053];
Institute for Collaborative Biotechnologies through the U.S. Army
Research Office [W911NF-09-D-0001]; CNSI-MRL Center for Scientific
Computing [DMR-1121053, CNS-0960316]
FX This work was supported by the MRSEC Program of the National Science
Foundation (NSF) under Award DMR-1121053 (D.J.A., D.V.K., A.C., S.-W.K.,
K.T.D., S.H., E.J.K.) and by the Institute for Collaborative
Biotechnologies through the U.S. Army Research Office (Contract
W911NF-09-D-0001) (S.G.J., K.L.K., D.K., G.H.F., C.J.H.). We also
acknowledge facilities support from the NSF-funded Materials Research
Facilities Network (www.mrfn.org) and the CNSI-MRL Center for Scientific
Computing (Grants DMR-1121053 and CNS-0960316).
NR 72
TC 66
Z9 67
U1 23
U2 267
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0002-7863
J9 J AM CHEM SOC
JI J. Am. Chem. Soc.
PD MAY 1
PY 2013
VL 135
IS 17
BP 6649
EP 6657
DI 10.1021/ja4019447
PG 9
WC Chemistry, Multidisciplinary
SC Chemistry
GA 137WO
UT WOS:000318469100042
PM 23594106
ER
PT J
AU Watson, JDB
Morrison, JJ
McNamee, IL
Evans, TW
Rasmussen, TE
AF Watson, J. Devin B.
Morrison, Jonathan J.
McNamee, Irma L.
Evans, Thomas W.
Rasmussen, Todd E.
TI Expanded Polytetrafluoroethylene (ePTFE) Versus Autologous Vein as a
Conduit for Vascular Reconstruction in Modern Combat Casualty Care
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Meeting Abstract
CT Vascular Annual Meeting of the Society-for-Vascular-Surgery (SVS)
CY MAY 30-JUN 01, 2013
CL San Francisco, CA
SP Soc Vasc Surg (SVS)
C1 [Watson, J. Devin B.] San Antonio Mil Med Ctr, San Antonio, TX USA.
[McNamee, Irma L.; Evans, Thomas W.; Rasmussen, Todd E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Morrison, Jonathan J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England.
NR 0
TC 0
Z9 0
U1 1
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD MAY
PY 2013
VL 57
IS 5
SU S
BP 11S
EP 11S
PG 1
WC Surgery; Peripheral Vascular Disease
SC Surgery; Cardiovascular System & Cardiology
GA 140VV
UT WOS:000318685300017
ER
PT J
AU McCown, M
Alleman, A
Sayler, K
Chandrashekar, R
Thatcher, B
Tyrrell, P
Stillman, B
Beall, M
Barbet, A
AF McCown, M.
Alleman, A.
Sayler, K.
Chandrashekar, R.
Thatcher, B.
Tyrrell, P.
Stillman, B.
Beall, M.
Barbet, A.
TI SURVEILLANCE FOR TICK-BORNE PATHOGENS IN MILITARY WORKING DOGS, SHELTER
ANIMALS AND PET POPULATIONS IN COLOMBIA
SO JOURNAL OF VETERINARY INTERNAL MEDICINE
LA English
DT Meeting Abstract
C1 [McCown, M.] USA, Vet Corps, Gainesville, FL USA.
[Alleman, A.; Sayler, K.; Barbet, A.] Univ Florida, Coll Vet Med, Gainesville, FL USA.
[Chandrashekar, R.; Thatcher, B.; Tyrrell, P.; Stillman, B.; Beall, M.] IDEXX Labs, Westbrook, ME USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0891-6640
J9 J VET INTERN MED
JI J. Vet. Intern. Med.
PD MAY-JUN
PY 2013
VL 27
IS 3
BP 722
EP 723
PG 2
WC Veterinary Sciences
SC Veterinary Sciences
GA 140MO
UT WOS:000318658400338
ER
PT J
AU Hamilton, JB
Moore, AD
Johnson, KA
Koenig, HG
AF Hamilton, Jill B.
Moore, Angelo D.
Johnson, Khishaana A.
Koenig, Harold G.
TI Reading The Bible for Guidance, Comfort, and Strength During Stressful
Life Events
SO NURSING RESEARCH
LA English
DT Article
DE mental health; religion; spirituality; stress and coping
ID QUALITATIVE CONTENT-ANALYSIS; AFRICAN-AMERICANS; OLDER-ADULTS; OUTCOMES
AB Background: The use of religious practices to promote mental health among African Americans is well documented. African Americans are more likely to report strong religious affiliations and to use religion over prescribed medications for mental health problems. However, few studies have explored how African Americans use religious practices in response to stressful life events.
Objective: The aim of this study is to examine how African American women and men find comfort in using scripture passages from The Bible.
Methods: Fifty-four African American adults residing in the Southeastern United States participated in a qualitative descriptive study using open-ended semistructured interviews. Participants were asked to describe their use of scripture passages from The Bible and the personal meanings associated with these scriptures in the context of a family death or life-threatening illness.
Results: These participants used scripture passages categorized as God as Protector, God as Beneficent, Praise and Thanksgiving, God as Healer, Memory of Forefathers, Prayers to God, and Life after Death. Few gender differences were noted. However, women were more likely to use scripture passages of God as Protector and Life after Death, whereas men were more likely to use God as Beneficent and God as Healer.
Discussion: The religious practice of reading scripture passages from The Bible is a mental health-promoting strategy used during stressful life events. The findings of this study have practical uses for nurses and can be used to inform acceptable and sensitive approaches in addressing mental health issues and spiritual care needs in African American patients.
C1 [Hamilton, Jill B.] Univ N Carolina, Sch Nursing, Chapel Hill, NC 27599 USA.
[Moore, Angelo D.] USA, Tripler Army Med Ctr, Honolulu, HI USA.
[Johnson, Khishaana A.] N Carolina State Univ, Raleigh, NC 27695 USA.
[Koenig, Harold G.] Duke Univ, Med Ctr, Ctr Spiritual Theol & Hlth, Durham, NC USA.
[Koenig, Harold G.] King Abdulaziz Univ, Jeddah 21413, Saudi Arabia.
RP Hamilton, JB (reprint author), Univ N Carolina, Sch Nursing, CB 7460, Chapel Hill, NC 27599 USA.
EM jhamilto@email.unc.edu
RI Koenig, Harold/F-7379-2011
NR 22
TC 4
Z9 4
U1 1
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0029-6562
J9 NURS RES
JI Nurs. Res.
PD MAY-JUN
PY 2013
VL 62
IS 3
BP 178
EP 184
DI 10.1097/NNR.0b013e31828fc816
PG 7
WC Nursing
SC Nursing
GA 138ZJ
UT WOS:000318550700005
PM 23636344
ER
PT J
AU Lundy, JB
AF Lundy, Jonathan B.
TI Commentary on "Predictors of Failed Primary Abdominal Closure in the
Trauma Patient with an Open Abdomen"
SO SOUTHERN MEDICAL JOURNAL
LA English
DT Editorial Material
ID FASCIAL APPROXIMATION
C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Lundy, JB (reprint author), USA, Inst Surg Res, 3400 Rawley Chambers Ave, Ft Sam Houston, TX 78234 USA.
EM Jonathan.lundy1@amedd.army.mil
NR 6
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0038-4348
J9 SOUTH MED J
JI South.Med.J.
PD MAY
PY 2013
VL 106
IS 5
BP 332
EP 333
DI 10.1097/SMJ.0b013e318292440f
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA 138YH
UT WOS:000318547300010
PM 23644643
ER
PT J
AU Ismayilova, R
Mody, R
Abdullayev, R
Amirova, K
Jabbarova, L
Ustun, N
Jahanov, M
Nasirova, E
Powers, M
Rivard, R
Hepburn, M
Bautista, CT
AF Ismayilova, Rita
Mody, Rupal
Abdullayev, Rakif
Amirova, Kamala
Jabbarova, Latafat
Ustun, Narmin
Jahanov, Musa
Nasirova, Emilya
Powers, Marilyn
Rivard, Robert
Hepburn, Matthew
Bautista, Christian T.
TI Short Report: Screening of Household Family Members of Brucellosis Cases
and Neighboring Community Members in Azerbaijan
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID REEMERGING ZOONOSIS; RISK-FACTORS
AB Brucellosis is an endemic zoonotic disease in Azerbaijan. The first human brucellosis case reported in 1922 was in Pardabil village of a region currently named Shabran. Household members of brucellosis index cases are a population at risk for brucellosis infection. The purpose of this study was to determine the rate of seropositivity of brucellosis among household and neighboring community members of brucellosis index cases in Azerbaijan. Twenty-one household members of 8 index brucellosis cases and 27 community neighbors were serologically tested for evidence of exposure by the serum agglutination test. Of these, the brucellosis seropositivity rate was 9.5% and 7.4%, respectively. Screening of household members of index cases and individuals who live in proximity to infected household members is a practical approach to increase the detection of brucellosis exposure.
C1 Republican Antiplague Stn, Baku, Azerbaijan.
[Mody, Rupal; Nasirova, Emilya; Powers, Marilyn; Rivard, Robert; Hepburn, Matthew] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Bautista, Christian T.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Ismayilova, Rita; Abdullayev, Rakif; Amirova, Kamala; Jabbarova, Latafat; Ustun, Narmin; Jahanov, Musa] Azerbaijan Republican Antiplague Stn, Baku, Azerbaijan.
RP Bautista, CT (reprint author), 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM rita2202@rambler.ru; rupal.mody@us.army.mil; doktor1952@rambler.ru;
kamalaemirova@mail.ru; latafat.jabbarova@gmail.com;
ustunnermin@yahoo.com; musa.jahanov@abta.az; Emilya.Nasirova@konsis.az;
Marilyn.Powers@us.army.mil; Robert.G.Rivard@us.army.mil;
matthew.hepburn@yahoo.com; Christian.Bautista@us.army.mil
FU Defense Threat Reduction Agency (DTRA) through the Cooperative
Biological Engagement Program (CBEP)
FX The Defense Threat Reduction Agency (DTRA) through the Cooperative
Biological Engagement Program (CBEP) funded this study.
NR 11
TC 4
Z9 4
U1 0
U2 1
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD MAY
PY 2013
VL 88
IS 5
BP 929
EP 931
DI 10.4269/ajtmh.12-0381
PG 3
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 136WR
UT WOS:000318394600020
PM 23478582
ER
PT J
AU Kobayashi, N
Pietropaolo, JA
Melby, JA
AF Kobayashi, Nobuhisa
Pietropaolo, Jill A.
Melby, Jeffrey A.
TI Wave Transformation and Runup on Dikes and Gentle Slopes
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article
DE Wave breaking; beach; surf zone; wave setup; swash; wave runup; wave
overtopping; dike
ID NATURAL BEACH; SWASH; PREDICTIONS; VELOCITIES; SETUP; MODEL
AB Coastal flood-risk mapping requires the prediction of wave runup and overtopping of dikes and beaches. The cross-shore numerical model CSHORE is adjusted to predict irregular wave runup on impermeable dikes. The model is compared with 137 wave runup tests and 97 wave overtopping tests. The seaward boundary of the computation is taken at the location where wave setup is negligible. The spectral period and peak period at this boundary location are specified as input. The model predicts the measured cross-shore variation of the spectral significant wave height on the barred and sloping beaches in front of the dikes. The measured 2% and 1% exceedence runup heights are predicted within errors of about 20% for the spectral period used as input to CSHORE. The model predicts the threshold of wave overtopping, but the minor wave overtopping rates can be predicted only within a factor of 10. The model is also compared with 120 tests for wave runup on gentle uniform slopes as well as wave runup data on natural beaches in order to assess the utility of the numerical model for coastal flood-risk mapping on sand beaches.
C1 [Kobayashi, Nobuhisa; Pietropaolo, Jill A.] Univ Delaware, Ctr Appl Coastal Res, Newark, DE 19716 USA.
[Melby, Jeffrey A.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Kobayashi, N (reprint author), Univ Delaware, Ctr Appl Coastal Res, Newark, DE 19716 USA.
EM nk@udel.edu
FU U.S. Army Corps of Engineers, Coastal and Hydraulics Laboratory
[W912HZ-10-P-0234, W912HZ-11-P-0173]
FX This study was supported by the U.S. Army Corps of Engineers, Coastal
and Hydraulics Laboratory under Contract Nos. W912HZ-10-P-0234 and
W912HZ-11-P-0173. We would like to thank Marcel van Gent for providing
his reports.
NR 24
TC 2
Z9 2
U1 2
U2 6
PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
J9 J COASTAL RES
JI J. Coast. Res.
PD MAY
PY 2013
VL 29
IS 3
BP 615
EP 623
DI 10.2112/JCOASTRES-D-11-00216.1
PG 9
WC Environmental Sciences; Geography, Physical; Geosciences,
Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA 137SI
UT WOS:000318457300011
ER
PT J
AU Goodin, C
AF Goodin, Christopher
TI Analytic expressions for the black-sky and white-sky albedos of the
cosine lobe model
SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND
VISION
LA English
DT Article
AB The cosine lobe model is a bidirectional reflectance distribution function (BRDF) that is commonly used in computer graphics to model specular reflections. The model is both simple and physically plausible, but physical quantities such as albedo have not been related to the parameterization of the model. In this paper, analytic expressions for calculating the black-sky and white-sky albedos from the cosine lobe BRDF model with integer exponents will be derived, to the author's knowledge for the first time. These expressions for albedo can be used to place constraints on physics-based simulations of radiative transfer such as high-fidelity ray-tracing simulations.
C1 USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Goodin, C (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM christopher.t.goodin@erdc.dren.mil
NR 15
TC 0
Z9 0
U1 0
U2 4
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1084-7529
J9 J OPT SOC AM A
JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis.
PD MAY
PY 2013
VL 30
IS 5
BP 854
EP 858
DI 10.1364/JOSAA.30.000854
PG 5
WC Optics
SC Optics
GA 138FL
UT WOS:000318494100006
PM 23695315
ER
PT J
AU Pratt, KA
Custard, KD
Shepson, PB
Douglas, TA
Pohler, D
General, S
Zielcke, J
Simpson, WR
Platt, U
Tanner, DJ
Huey, LG
Carlsen, M
Stirm, BH
AF Pratt, Kerri A.
Custard, Kyle D.
Shepson, Paul B.
Douglas, Thomas A.
Poehler, Denis
General, Stephan
Zielcke, Johannes
Simpson, William R.
Platt, Ulrich
Tanner, David J.
Huey, L. Gregory
Carlsen, Mark
Stirm, Brian H.
TI Photochemical production of molecular bromine in Arctic surface
snowpacks
SO NATURE GEOSCIENCE
LA English
DT Article
ID OZONE DESTRUCTION; SEA-SALT; BOUNDARY-LAYER; POLAR SUNRISE; ICE;
DEPLETION; FROZEN; SNOW; TROPOSPHERE; RELEASE
AB Following the springtime polar sunrise, ozone concentrations in the lower troposphere episodically decline to near-zero levels(1). These ozone depletion events are initiated by an increase in reactive bromine levels in the atmosphere(2-5). Under these conditions, the oxidative capacity of the Arctic troposphere is altered, leading to the removal of numerous transported trace gas pollutants, including mercury(6). However, the sources and mechanisms leading to increased atmospheric reactive bromine levels have remained uncertain, limiting simulations of Arctic atmospheric chemistry with the rapidly transforming sea-ice landscape(7,8). Here, we examine the potential for molecular bromine production in various samples of saline snow and sea ice, in the presence and absence of sunlight and ozone, in an outdoor snow chamber in Alaska. Molecular bromine was detected only on exposure of surface snow ( collected above tundra and first-year sea ice) to sunlight. This suggests that the oxidation of bromide is facilitated by a photochemical mechanism, which was most efficient for more acidic samples characterized by enhanced bromide to chloride ratios. Molecular bromine concentrations increased significantly when the snow was exposed to ozone, consistent with an interstitial air amplification mechanism. Aircraft-based observations confirm that bromine oxide levels were enhanced near the snow surface. We suggest that the photochemical production of molecular bromine in surface snow serves as a major source of reactive bromine, which leads to the episodic depletion of tropospheric ozone in the Arctic springtime.
C1 [Pratt, Kerri A.; Custard, Kyle D.; Shepson, Paul B.; Carlsen, Mark] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA.
[Shepson, Paul B.] Purdue Univ, Dept Earth Atmospher & Planetary Sci, W Lafayette, IN 47907 USA.
[Shepson, Paul B.] Purdue Univ, Purdue Climate Change Res Ctr, W Lafayette, IN 47907 USA.
[Douglas, Thomas A.] USA, Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA.
[Poehler, Denis; General, Stephan; Zielcke, Johannes; Platt, Ulrich] Heidelberg Univ, Inst Environm Phys, D-69117 Heidelberg, Germany.
[Simpson, William R.] Univ Alaska Fairbanks, Inst Geophys, Fairbanks, AK 99775 USA.
[Simpson, William R.] Univ Alaska Fairbanks, Dept Chem, Fairbanks, AK 99775 USA.
[Tanner, David J.; Huey, L. Gregory] Georgia Inst Technol, Sch Earth & Atmospher Sci, Atlanta, GA 30332 USA.
[Stirm, Brian H.] Purdue Univ, Dept Aviat Technol, W Lafayette, IN 47907 USA.
RP Pratt, KA (reprint author), Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA.
EM kapratt@purdue.edu
RI Pratt, Kerri/F-8025-2010; Simpson, William/I-2859-2014
OI Pratt, Kerri/0000-0003-4707-2290; Simpson, William/0000-0002-8596-7290
FU National Science Foundation Office of Polar Programs [ARC-1107695];
National Aeronautics and Space Administration (NASA) Cryospheric
Sciences Program as a part of the NASA Interdisciplinary Research on
Arctic Sea Ice and Tropospheric Chemical Change [09-IDS09-31]; National
Science Foundation Postdoctoral Fellowship in Polar Regions Research
FX Financial support was provided by the National Science Foundation Office
of Polar Programs (ARC-1107695) and the National Aeronautics and Space
Administration (NASA) Cryospheric Sciences Program as a part of the NASA
Interdisciplinary Research on Arctic Sea Ice and Tropospheric Chemical
Change (09-IDS09-31). K.A.P. is supported by a National Science
Foundation Postdoctoral Fellowship in Polar Regions Research. S. V.
Nghiem is thanked for BROMEX organization. The MODIS image in Fig. 3 was
provided by the NASA Rapid Response MODIS Subset in support of BROMEX.
R. Replogle (Purdue University) is thanked for construction of the snow
chamber. Solar radiation data were acquired by and obtained from the
NOAA/ESRL/GMD Solar Radiation group. We are grateful to UMIAQ and CH2M
Hill Polar Services for field logistical assistance. M. O. L. Cambaliza
and D. Caulton (Purdue University) are thanked for aircraft attitude
data used in the DOAS analysis. E. Boone (Purdue University) is thanked
for aerosol data analysis. M. Sturm (CRREL) is thanked for chamber
design advice. J. W. Halfacre (Purdue University) is thanked for
calibration of the ozone monitor. R. Lieb-Lappen (Dartmouth University)
is thanked for field discussions. This is publication 1241 of the Purdue
Climate Change Research Center.
NR 30
TC 45
Z9 46
U1 28
U2 124
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1752-0894
J9 NAT GEOSCI
JI Nat. Geosci.
PD MAY
PY 2013
VL 6
IS 5
BP 351
EP 356
DI 10.1038/NGEO1779
PG 6
WC Geosciences, Multidisciplinary
SC Geology
GA 134QA
UT WOS:000318227000013
ER
PT J
AU Schumacher, PD
Doyle, JL
Schenk, JO
Clark, SB
AF Schumacher, Paul D.
Doyle, Jamie L.
Schenk, James O.
Clark, Sue B.
TI Electroanalytical chemistry of lanthanides and actinides
SO REVIEWS IN ANALYTICAL CHEMISTRY
LA English
DT Article
DE electrochemistry; electrodes; f-elements; plutonium; pre-concentration
ID CARBON-PASTE ELECTRODE; ADSORPTIVE STRIPPING VOLTAMMETRY; CONTINUOUS
CYCLIC VOLTAMMETRY; ION-EXCHANGE CHROMATOGRAPHY; MERCURY FILM
ELECTRODES; AQUEOUS-SOLUTION; ELECTROCHEMICAL PROPERTIES; NONAQUEOUS
MEDIA; ORGANIC-SOLVENTS; GLASSY-CARBON
AB The electrochemical properties of lanthanides (Ln) and actinides (An) are reviewed. This review summarizes papers from 1986 to 2011 with a primary focus on the electrochemical and redox properties of Ln/An elements in aqueous solution and their responses to a variety of electrode materials including Hg, Hg films, solid electrodes, modified carbon paste, and microelectrodes. A section is also devoted to the electrochemical properties and responses of Ln and An in nonaqueous and mixed solvent systems.
C1 [Schumacher, Paul D.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA.
[Doyle, Jamie L.; Schenk, James O.; Clark, Sue B.] Washington State Univ, Dept Chem, Pullman, WA 99164 USA.
RP Clark, SB (reprint author), Washington State Univ, Dept Chem, Pullman, WA 99164 USA.
EM s_clark@wsu.edu
FU Washington State University; Academic Research Initiative of the Joint
Domestic Nuclear Detection Office, Department of Homeland Security;
National Science Foundation [ECCS-0833548, DN-077-ARI-03302]; US
Department of Energy, Office of Science, Heavy Elements Program
[DE-SC-0004102]
FX P.D.S. acknowledges the support of the US Army while in residence at
Washington State University. All the authors acknowledge funding from
the Academic Research Initiative of the Joint Domestic Nuclear Detection
Office, Department of Homeland Security, and the National Science
Foundation, for funding under grant numbers ECCS-0833548 and
DN-077-ARI-03302. In addition, S.B.C. acknowledges support from the US
Department of Energy, Office of Science, Heavy Elements Program, grant
number DE-SC-0004102. We also gratefully acknowledge two reviewers whose
constructive comments helped us to improve this manuscript
significantly.
NR 83
TC 1
Z9 1
U1 4
U2 83
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0793-0135
J9 REV ANAL CHEM
JI Rev. Anal. Chem.
PD MAY
PY 2013
VL 32
IS 2
BP 159
EP 171
DI 10.1515/revac-2012-0032
PG 13
WC Chemistry, Analytical
SC Chemistry
GA 137BA
UT WOS:000318408500006
ER
PT J
AU Tannenbaum, LV
Gulsby, WD
Zobel, SS
Miller, KV
AF Tannenbaum, Lawrence V.
Gulsby, William D.
Zobel, Shaina S.
Miller, Karl V.
TI Where Deer Roam: Chronic Yet Acute Site Exposures Preclude Ecological
Risk Assessment
SO RISK ANALYSIS
LA English
DT Article
DE Deer; ecological risk assessment; global positioning system technology;
spatial relevance
AB Global positioning system (GPS) technology has made possible the detailed tracking of the spatial movements of wildlife. Using GPS tracking collars placed on female white-tailed deer (Odocoileus virginianus) over a protracted period, we illustrate that this species is spatially irrelevant for consideration in ecological risk assessments (ERAs) for commonly assessed contaminated sites. Specifically, deer movements do not allow for a sufficiency of chemical exposures to occur such that toxicological endpoints would be triggered. Deer are spatially irrelevant not only because their home ranges and overall utilized areas dwarf prototypical hazardous waste sites. They are also inappropriate for assessment because they only minimally contact reasonably sized preferred locations, this while demonstrating a confounding high degree of site affinity for them. Our spatial movements analysis suggests that deer introduce the ERA novelty of a species displaying elements of both chronic and acute site exposure. We further suggest that other large commonly assessed high-profile mammals could also be found to be spatially irrelevant for ERAs were they to submit to the GPS tracking and subsequent data analysis we performed for the deer. Recognizing that certain receptors need not be considered in ERAs can help to simplify the ERA process.
C1 [Tannenbaum, Lawrence V.; Zobel, Shaina S.] USA, Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA.
[Gulsby, William D.; Miller, Karl V.] Univ Georgia, Warnell Sch Forestry & Nat Resources, Athens, GA 30602 USA.
RP Tannenbaum, LV (reprint author), USA, Environm Hlth Risk Assessment Program, Inst Publ Hlth, Publ Hlth Command,MCHB IP REH,APG EA, Bldg 1675, Aberdeen Proving Ground, MD 21010 USA.
EM larry.tannenbaum@us.army.mil
FU U.S. Army Environmental Command
FX This work was supported by funds provided by the U.S. Army Environmental
Command (Mr. Jim Daniel). The authors wish to thank Andrew Leitzer for
his assistance with graphics, Jeffrey Leach and Sherri Hutchens for
their helpful reviews, and Ms. Joyce Woods for her editing assistance.
The opinions or assertions contained herein are the views of the authors
and are not to be construed as official or as reflecting the views of
the U.S. Army Public Health Command, the U.S. Army, or the Department of
Defense.
NR 23
TC 0
Z9 0
U1 1
U2 11
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0272-4332
EI 1539-6924
J9 RISK ANAL
JI Risk Anal.
PD MAY
PY 2013
VL 33
IS 5
BP 789
EP 799
DI 10.1111/j.1539-6924.2012.01890.x
PG 11
WC Public, Environmental & Occupational Health; Mathematics,
Interdisciplinary Applications; Social Sciences, Mathematical Methods
SC Public, Environmental & Occupational Health; Mathematics; Mathematical
Methods In Social Sciences
GA 137MT
UT WOS:000318440700009
PM 22985105
ER
PT J
AU Costache, MC
Vaughan, AD
Qu, H
Ducheyne, P
Devore, DI
AF Costache, M. C.
Vaughan, A. D.
Qu, H.
Ducheyne, P.
Devore, D. I.
TI Tyrosine-derived polycarbonate-silica xerogel nanocomposites for
controlled drug delivery
SO ACTA BIOMATERIALIA
LA English
DT Article
DE Nanocomposites; Silica xerogel; Tyrosine-derived co-polymers; Mechanical
properties; Controlled drug release
ID CONTROLLED-RELEASE; SOL-GEL; BONE; BIOMATERIALS; REGENERATION;
SCAFFOLDS; DISCOVERY; COMBINATION; ANTIBIOTICS; VANCOMYCIN
AB Biodegradable polymer ceramic composites offer significant potential advantages in biomedical applications where the properties of either polymers or ceramics alone are insufficient to meet performance requirements. Here we demonstrate the highly tunable mechanical and controlled drug delivery properties accessible with novel biodegradable nanocomposites prepared by non-covalent binding of silica xerogels and co-polymers of tyrosine-poly(ethylene glycol)-derived poly(ether carbonate). The Young's moduli of the nanocomposites exceed by factors of 5-20 times those of the co-polymers or of composites made with micron scale silica particles. Increasing the fraction of xerogel in the nanocomposites increases the glass transition temperature and the mechanical strength, but decreases the equilibrium water content, which are all indicative of strong non-covalent interfacial interactions between the copolymers and the silica nanoparticles. Sustained, tunable controlled release of both hydrophilic and hydrophobic therapeutic agents from the nanocomposites is demonstrated with two clinically significant drugs, rifampicin and bupivacaine. Bupivacaine exhibits an initial small burst release followed by slow release over the 7 day test period. Rifampicin release fits the diffusion-controlled Higuchi model and the amount released exceeds the dosage required for treatment of clinically challenging infections. These nanocomposites are thus attractive biomaterials for applications such as wound dressings, tissue engineering substrates and stents. Published by Elsevier Ltd. on behalf of Acta Materialia Inc.
C1 [Costache, M. C.] Rutgers State Univ, New Jersey Ctr Biomat, Piscataway, NJ 08854 USA.
[Vaughan, A. D.; Devore, D. I.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Qu, H.; Ducheyne, P.] Univ Penn, Dept Bioengn, Ctr Bioact Mat & Tissue Engn, Philadelphia, PA 19104 USA.
RP Devore, DI (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM david.devore@us.army.mil
OI Qu, Haibo/0000-0003-4488-4277
FU US Army [W81XWH-07-1-0438]; US Army Institute of Surgical Research; New
Jersey Center for Biomaterials, Rutgers University
FX This work was supported in part by US Army contract no.
W81XWH-07-1-0438. The US Army Medical Research Acquisition Activity,
Fort Detrick, MD, was the awarding and administering acquisition office.
The content of the manuscript does not necessarily reflect the position
or the policy of the Government, and no official endorsement should be
inferred. Support from the US Army Institute of Surgical Research and
the New Jersey Center for Biomaterials, Rutgers University, is
gratefully acknowledged. The authors thank Dr. Das Bolikal and Dr.
Joachim Kohn of Rutgers University for their assistance.
NR 55
TC 10
Z9 10
U1 4
U2 52
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1742-7061
J9 ACTA BIOMATER
JI Acta Biomater.
PD MAY
PY 2013
VL 9
IS 5
BP 6544
EP 6552
DI 10.1016/j.actbio.2013.01.034
PG 9
WC Engineering, Biomedical; Materials Science, Biomaterials
SC Engineering; Materials Science
GA 134GY
UT WOS:000318199600024
PM 23395749
ER
PT J
AU Mansi, IA
Mortensen, EM
Pugh, MJ
Wegner, M
Frei, CR
AF Mansi, Ishak A.
Mortensen, Eric M.
Pugh, Mary J.
Wegner, Michael
Frei, Christopher R.
TI Incidence of Musculoskeletal and Neoplastic Diseases in Patients on
Statin Therapy: Results of a Retrospective Cohort Analysis
SO AMERICAN JOURNAL OF THE MEDICAL SCIENCES
LA English
DT Article
DE Statin; Arthropathy; Neoplasm; Musculoskeletal; Side effects
ID DENSITY-LIPOPROTEIN CHOLESTEROL; CORONARY-DISEASE; GENERAL-PRACTICE;
TENDON-RUPTURE; CANCER; RISK; TRIALS; METAANALYSIS; PAIN; ROSUVASTATIN
AB Background: Because of their beneficial cardiovascular effects, several studies have recently advocated starting statins at a young age for primary prevention. However, some reports suggest that statin therapy may be associated with an increased incidence of musculoskeletal and neoplastic diseases. This study was conducted to investigate the incidence of various musculoskeletal and neoplastic diseases in statin users and nonusers. Methods: A retrospective cohort study of patients in the San Antonio Military Multi-Service Market during the period from October 1, 2003, to March 5, 2010, was conducted. The International Classification of Diseases, 9th edition, diagnosis codes between 2 cohort groups-statin users and nonusers-were compared. Statin users were those patients with at least one 3-month prescription for a statin in the fiscal year 2004. Nonusers were those patients who received a prescription-but not a statin-during the period of the study. Both groups were assessed for the development of musculoskeletal and neoplastic diseases in the following 4-year period (October 1, 2004, to September 30, 2009). Results: A total of 92,360 patients were identified: 12,980 statin users and 45,997 nonusers. After adjusting for age, sex and Charlson comorbidity index, statin users had significantly higher rates of osteoarthritis and arthropathy (odds ratio: 1.26; 95% confidence interval: 1.19-1.33), and dorsopathies, rheumatism and chondropathies (odds ratio: 1.20; 95% confidence interval: 1.12-1.27). Conclusions: In this retrospective analysis, statin use was associated with an increased incidence of musculoskeletal diseases, including arthropathy. Further studies are needed to provide physicians and their patients with adequate information regarding statin therapy, particularly if recommended for primary prevention in younger populations.
C1 [Mansi, Ishak A.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Brooke Army Med Ctr, San Antonio, TX 78229 USA.
[Mortensen, Eric M.] Univ Texas SW Med Ctr Dallas, Vet Affairs North Texas Hlth Care Syst, Dallas, TX 75390 USA.
[Pugh, Mary J.] Univ Texas Hlth Sci Ctr San Antonio, Vet Affairs South Texas Hlth Care Syst, San Antonio, TX 78229 USA.
[Wegner, Michael] Brooke Army Med Ctr, Business Operat Div, Ft Sam Houston, TX 78234 USA.
[Frei, Christopher R.] Univ Texas Austin, Coll Pharm, Austin, TX 78712 USA.
[Frei, Christopher R.] Univ Texas Hlth Sci Ctr San Antonio, Sch Med, Pharmacotherapy Educ & Res Ctr, San Antonio, TX 78229 USA.
RP Mansi, IA (reprint author), Brooke Army Med Ctr, Internal Med Serv, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA.
EM Iishak.mansi@us.army.mil
OI Mortensen, Eric/0000-0002-3880-5563
FU U.S. National Institutes of Health (NIH) in the form of an NIH KL2
career development award [RR025766]; AstraZeneca; Bristol-Myers Squibb;
Elan; Forest; Ortho-McNeil Janssen; Pfizer
FX C.R. Frei is supported by the U.S. National Institutes of Health (NIH)
in the form of an NIH KL2 career development award (RR025766). In
addition, he also received research grants and/or served as a scientific
consultant/advisor for AstraZeneca, Bristol-Myers Squibb, Elan, Forest,
Ortho-McNeil Janssen and Pfizer.
NR 49
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U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0002-9629
J9 AM J MED SCI
JI Am. J. Med. Sci.
PD MAY
PY 2013
VL 345
IS 5
BP 343
EP 348
DI 10.1097/MAJ.0b013e31825b8edf
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA 130LH
UT WOS:000317917800003
PM 22975580
ER
PT J
AU Kim, J
Ebertowski, J
Janiga, M
Arzola, J
Gillespie, G
Fountain, M
Soderdahl, D
Canby-Hagino, E
Elsamanoudi, S
Gurski, J
Davis, JW
Parker, PA
Boyd, DD
AF Kim, Jeri
Ebertowski, James
Janiga, Matthew
Arzola, Jorge
Gillespie, Gayle
Fountain, Michael
Soderdahl, Douglas
Canby-Hagino, Edith
Elsamanoudi, Sally
Gurski, Jennifer
Davis, John W.
Parker, Patricia A.
Boyd, Douglas D.
TI Many young men with prostate-specific antigen (PSA) screen-detected
prostate cancers may be candidates for active surveillance
SO BJU INTERNATIONAL
LA English
DT Article
DE very-low-risk prostatic neoplasms; active surveillance; risk assessment;
overtreatment
ID RADICAL PROSTATECTOMY; INSIGNIFICANT; SURVIVAL; OUTCOMES; AGE;
DIAGNOSIS; DATABASE; TIME
AB What's known on the subject? and What does the study add? Little is known as to the potential for over-treatment of young men diagnosed with prostate cancer. We show that for men aged 55 years with PSA screen-detected disease, 45% of the tumours are classified as very low risk and 85% of these have favourable pathology, yet most are actively treated. These findings raise the spectre of over-treatment for a group of men likely to be affected by treatment side-effects. Objective To identify a population of young men (aged <55 years at diagnosis) with very-low-risk prostate cancer (stage cT1c, with prostate-specific antigen [PSA] density of <0.15ng/mL/g, Gleason score 6, and 2 positive biopsy cores with <50% tumour involvement) that may be candidates for active surveillance (AS). Patients and Methods We queried a Department of Defense tumour registry and hard-copy records for servicemen diagnosed with prostate cancer from 1987 to 2010. Statistical analyses were undertaken using Fisher's exact and chi-square testing. Results From 19871991 and 20072010, PSA screen-detected tumours diagnosed in men aged 55 years rose >30-fold. Data for a subset of men (174) with PSA screen-detected cancer were evaluable for disease risk assessment. Of the 174 men with screen-detected disease, 81 (47%) had very-low-risk disease. Of that group, 96% (78/81) selected treatment and, of 57 men undergoing radical prostatectomy (RP), the tumours of 49 (86%) carried favourable pathology (organ confined, <10% gland involvement, Gleason 6). Conclusions Nearly half of young men with PSA screen-detected prostate cancer are AS candidates but the overwhelming majority seek treatment. Considering that many tumours show favourable pathology at RP, there is a possibility that these patients may benefit from AS management.
C1 [Kim, Jeri] Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA.
[Ebertowski, James; Soderdahl, Douglas; Canby-Hagino, Edith] San Antonio Mil Med Ctr, San Antonio, TX USA.
[Janiga, Matthew] David Grant USAF Med Ctr, Med Grp 60, Travis Afb, CA USA.
[Arzola, Jorge; Gillespie, Gayle] Wright Patterson Med Ctr, Med Grp 88, Dayton, OH USA.
[Fountain, Michael] Eglin Reg Hosp, Med Grp 96, Eglin AFB, FL USA.
[Elsamanoudi, Sally] Walter Reed Natl Mil Med Ctr, Ctr Prostate Dis Res, Bethesda, MD USA.
[Gurski, Jennifer] Womack Army Med Ctr, Ft Bragg, NC USA.
[Davis, John W.] Univ Texas MD Anderson Canc Ctr, Dept Urol, Houston, TX 77030 USA.
[Parker, Patricia A.] Univ Texas MD Anderson Canc Ctr, Dept Behav Sci, Houston, TX 77030 USA.
[Boyd, Douglas D.] Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA.
RP Boyd, DD (reprint author), Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Unit 173, 1515 Holcombe Blvd, Houston, TX 77030 USA.
EM dboyd@mdanderson.org
FU National Institutes of Health/National Center for Research Resources
Clinical and Translational Science Award [UL1 RR024148]; National
Institutes of Health through MD Anderson's Cancer Center Support Grant
[5 P30 CA016672]
FX None declared. Source of funding: supported in part by a National
Institutes of Health/National Center for Research Resources Clinical and
Translational Science Award grant UL1 RR024148, awarded to D.D.B., and
in part by the National Institutes of Health through MD Anderson's
Cancer Center Support Grant, 5 P30 CA016672.
NR 31
TC 7
Z9 7
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1464-4096
J9 BJU INT
JI BJU Int.
PD MAY
PY 2013
VL 111
IS 6
BP 934
EP 940
DI 10.1111/j.1464-410X.2012.11768.x
PG 7
WC Urology & Nephrology
SC Urology & Nephrology
GA 134SG
UT WOS:000318234100014
PM 23350937
ER
PT J
AU Jugg, B
Fairhall, S
Smith, A
Rutter, S
Mann, T
Perrott, R
Jenner, J
Salguero, J
Shute, J
Sciuto, AM
AF Jugg, B.
Fairhall, S.
Smith, A.
Rutter, S.
Mann, T.
Perrott, R.
Jenner, J.
Salguero, J.
Shute, J.
Sciuto, A. M.
TI N-acetyl-L-cysteine protects against inhaled sulfur mustard poisoning in
the large swine
SO CLINICAL TOXICOLOGY
LA English
DT Article
DE Acute lung injury; Inflammation; Inhalation; Mono-sulfoxide; Porcine
physiology; Thiol
ID INDUCED LUNG INJURY; MASS-SPECTROMETRY; ANESTHETIZED PIG; EXPOSURE;
ACETYLCYSTEINE; URINE; QUANTITATION; INHALATION; IMPROVES; SYSTEM
AB Context. Sulfur mustard is a blister agent that can cause death by pulmonary damage. There is currently no effective treatment. N-acetyl-L-cysteine (NAC) has mucolytic and antioxidant actions and is an important pre-cursor of cellular glutathione synthesis. These actions may have potential to reduce mustard-induced lung injury. Objective. Evaluate the effect of nebulised NAC as a post-exposure treatment for inhaled sulfur mustard in a large animal model. Materials and methods. Fourteen anesthetized, surgically prepared pigs were exposed to sulfur mustard vapor (100 mu g.kg(-1), 10 min) and monitored, spontaneously breathing, to 12 h. Control animals had no further intervention (n = 6). Animals in the treatment group were administered multiple inhaled doses of NAC (1 ml of 200 mg.ml(-1) Mucomyst (TM) at + 30 min, 2, 4, 6, 8, and 10 h post-exposure, n = 8). Cardiovascular and respiratory parameters were recorded. Arterial blood was collected for blood gas analysis while blood and bronchoalveolar lavage fluid were collected for hematology and inflammatory cell analysis. Urine was collected to detect a sulfur mustard breakdown product. Lung tissue samples were taken for histopathological and post-experimental analyses. Results. Five of six sulfur mustard-exposed animals survived to 12 h. Arterial blood oxygenation (PaO2) and saturation levels were significantly decreased at 12 h. Arterial blood carbon dioxide (PaCO2) significantly increased, and arterial blood pH and bicarbonate (HCO3-) significantly decreased at 12 h. Shunt fraction was significantly increased at 12 h. In the NAC-treated group all animals survived to 12 h (n = 8). There was significantly improved arterial blood oxygen saturation, HCO3- levels, and shunt fraction compared to those of the sulfur mustard controls. There were significantly fewer neutrophils and lower concentrations of protein in lavage compared to sulfur mustard controls. Discussion. NAC's mucolytic and antioxidant properties may be responsible for the beneficial effects seen, improving clinically relevant physiological indices affected by sulfur mustard exposure. Conclusion. Beneficial effects of nebulized NAC were apparent following inhaled sulfur mustard exposure. Further therapeutic benefit may result from a combination therapy approach.
C1 [Jugg, B.; Fairhall, S.; Smith, A.; Rutter, S.; Mann, T.; Perrott, R.; Jenner, J.] DSTL, Salisbury SP4 0JQ, Wilts, England.
[Salguero, J.] Anim Hlth & Vet Labs Agcy, Specialist Sci Support, Addlestone, Surrey, England.
[Shute, J.] Univ Portsmouth, Portsmouth, Hants, England.
[Sciuto, A. M.] USA, Med Res Inst Chem Def, Med Toxicol Branch, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA.
RP Jugg, B (reprint author), DSTL, Room C22,Bldg 04, Salisbury SP4 0JQ, Wilts, England.
EM bjjugg@dstl.gov.uk; ajsmith@dstl.gov.uk
OI Salguero, Francisco Javier/0000-0002-5315-3882
FU Defense Threat Reduction Agency (US Department of Defense) [HDTRA
1-07-C-0027, W81XWH-09-C-0083]; [RESP.CBM.01.10.RC.009]
FX This work was supported by the Defense Threat Reduction Agency (US
Department of Defense) under Contracts HDTRA 1-07-C-0027 and
W81XWH-09-C-0083 in support of RESP.CBM.01.10.RC.009.
NR 35
TC 14
Z9 14
U1 3
U2 20
PU INFORMA HEALTHCARE
PI NEW YORK
PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA
SN 1556-3650
J9 CLIN TOXICOL
JI Clin. Toxicol.
PD MAY
PY 2013
VL 51
IS 4
BP 216
EP 224
DI 10.3109/15563650.2013.780208
PG 9
WC Toxicology
SC Toxicology
GA 130SD
UT WOS:000317938600005
PM 23547745
ER
PT J
AU Dean, RG
Houston, JR
AF Dean, R. G.
Houston, J. R.
TI Recent sea level trends and accelerations: Comparison of tide gauge and
satellite results
SO COASTAL ENGINEERING
LA English
DT Article
DE Sea level rise; Tide gauge records; Satellite altimetry; Sea level
acceleration
ID TOPEX/POSEIDON; CALIBRATION; JASON-1; SURFACE
AB A comprehensive set of 456 monthly tide gauge records is analyzed for trend and acceleration over the same period that satellite altimetry was analyzed (1993 to 2011). Additionally, a 90 tide gauge record subset is analyzed for which GPS data are available. The selection criterion for the tide gauge data is 85% data completion. All measurements are adjusted for vertical land motion. Results from 456 pairs of tide gauges, adjusted for Global Isostatic Adjustment, and satellite recordings located within 1 root-mean-square latitude and longitude separation differences are compared. The tide gauge trends and accelerations are adjusted for spatial bias using the more globally dense satellite data.
The average trends of the 456 and 90 gauge sets (3.26 and 2.68 mm/year, respectively) agree reasonably well with the global trend average of the satellite data (3.09 mm/year). Average trends for the 456 tide gauges are also in good agreement (within 95% confidence limits) with trends based on satellite data within the 10 satellite proximity criterion (326 and 331 mm/year, respectively). The trends for the 90 gauges with GPS nearby and qualifying satellite locations are 2.68 and 2.74 mm/year, respectively. For all datasets analyzed, the accelerations are quite strongly negative but the uncertainty is relatively large. Adjustment of the tide gauge trends for spatial bias modified both trends and accelerations significantly and decreased trend differences between the 456 and 90 gauge datasets. The spatially adjusted tide gauge trends (2.95 and 2.72 mm/year, respectively for the 456 and 90 tide gauges sets) are somewhat less than the 10 spatially adjusted satellite data (3.09 mm/year). Whether the increased sea level trend of approximately 3 mm/year measured by the satellites since the 1990's is a long-term increase from the 20th Century value of approximately 1.7 mm/year or part of a cycle will require longer records; however, the negative accelerations support some cyclic character. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Dean, R. G.] Univ Florida, Gainesville, FL 32610 USA.
[Houston, J. R.] Engineer Res & Dev Ctr, Vicksburg, MS USA.
RP Dean, RG (reprint author), Univ Florida, Gainesville, FL 32610 USA.
EM dean@coastal.ufl.edu
NR 20
TC 11
Z9 11
U1 1
U2 27
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-3839
J9 COAST ENG
JI Coast. Eng.
PD MAY
PY 2013
VL 75
BP 4
EP 9
DI 10.1016/j.coastaleng.2013.01.001
PG 6
WC Engineering, Civil; Engineering, Ocean
SC Engineering
GA 112HL
UT WOS:000316583200002
ER
PT J
AU Nath, AK
Roberts, LD
Liu, Y
Mahon, SB
Kim, S
Ryu, JH
Werdich, A
Januzzi, JL
Boss, GR
Rockwood, GA
MacRae, CA
Brenner, M
Gerszten, RE
Peterson, RT
AF Nath, Anjali K.
Roberts, Lee D.
Liu, Yan
Mahon, Sari B.
Kim, Sonia
Ryu, Justine H.
Werdich, Andreas
Januzzi, James L.
Boss, Gerry R.
Rockwood, Gary A.
MacRae, Calum A.
Brenner, Matthew
Gerszten, Robert E.
Peterson, Randall T.
TI Chemical and metabolomic screens identify novel biomarkers and antidotes
for cyanide exposure
SO FASEB JOURNAL
LA English
DT Article
DE mitochondria; inosine; zebrafish; riboflavin
ID CYTOCHROME-C-OXIDASE; SODIUM-NITROPRUSSIDE; LIPID-PEROXIDATION; SMALL
MOLECULES; DIFFERENT MODES; BILE-ACIDS; INTOXICATION; CELLS; INHIBITION;
ZEBRAFISH
AB Exposure to cyanide causes a spectrum of cardiac, neurological, and metabolic dysfunctions that can be fatal. Improved cyanide antidotes are needed, but the ideal biological pathways to target are not known. To understand better the metabolic effects of cyanide and to discover novel cyanide antidotes, we developed a zebrafish model of cyanide exposure and scaled it for high-throughput chemical screening. In a screen of 3120 small molecules, we discovered 4 novel antidotes that block cyanide toxicity. The most potent antidote was riboflavin. Metabolomic profiling of cyanide-treated zebrafish revealed changes in bile acid and purine metabolism, most notably by an increase in inosine levels. Riboflavin normalizes many of the cyanide-induced neurological and metabolic perturbations in zebrafish. The metabolic effects of cyanide observed in zebrafish were conserved in a rabbit model of cyanide toxicity. Further, humans treated with nitroprusside, a drug that releases nitric oxide and cyanide ions, display increased circulating bile acids and inosine. In summary, riboflavin may be a novel treatment for cyanide toxicity and prophylactic measure during nitroprusside treatment, inosine may serve as a biomarker of cyanide exposure, and metabolites in the bile acid and purine metabolism pathways may shed light on the pathways critical to reversing cyanide toxicity.-Nath, A. K., Roberts, L. D., Liu, Y., Mahon, S. B., Kim, S., Ryu, J. H., Werdich, A., Januzzi, J. L., Boss, G. R., Rockwood, G. A., MacRae, C. A., Brenner, M., Gerszten, R. E., Peterson, R. T. Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure. FASEB J. 27, 1928-1938 (2013). www.fasebj.org
C1 [Nath, Anjali K.; Roberts, Lee D.; Liu, Yan; Kim, Sonia; Ryu, Justine H.; Januzzi, James L.; Gerszten, Robert E.; Peterson, Randall T.] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Cardiovasc Res Ctr, Charlestown, MA USA.
[Nath, Anjali K.; Roberts, Lee D.; Liu, Yan; Kim, Sonia; Ryu, Justine H.; Januzzi, James L.; Gerszten, Robert E.; Peterson, Randall T.] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Div Cardiol,Dept Med, Charlestown, MA USA.
[Nath, Anjali K.; Roberts, Lee D.; Liu, Yan; Gerszten, Robert E.; Peterson, Randall T.] Broad Inst, Cambridge, MA USA.
[Mahon, Sari B.; Brenner, Matthew] Univ Calif Irvine, Irvine Med Ctr, Orange, CA 92668 USA.
[Werdich, Andreas; MacRae, Calum A.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Cardiol,Dept Med, Boston, MA 02115 USA.
[Boss, Gerry R.] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA.
[Rockwood, Gary A.] USA, Analyt Toxicol Div, Med Res Inst Chem Def, Aberdeen Proving Ground, MD USA.
RP Nath, AK (reprint author), Cardiovasc Res Ctr, 149 13th St, Charlestown, MA 02129 USA.
EM anath@cvrc.mgh.harvard.edu; peterson@cvrc.mgh.harvard.edu
OI Roberts, Lee/0000-0002-1455-5248
FU U.S. National Institutes of Health (NIH) grant [T32 HL-007208]; NIH
Countermeasures Against Chemical Threats (Counter ACT) [U54NS063718,
U54NS079201]; CounterACT Program, NIH Office of the Director; National
Institute of Allergy and Infectious Diseases, NIH/U.S. Army Medical
Research and Materiel Command [Y1-OD-9611-01/A120-B.P2009-1]
FX Funding for this project has been provided by U.S. National Institutes
of Health (NIH) grant T32 HL-007208 (A.K.N. and Y.L.) and NIH
Countermeasures Against Chemical Threats (Counter ACT) grants
U54NS063718 and U54NS079201 (S.B.M. and M.B.) and U54NS079201 (R.T.P).
The zebrafish research was supported, in part, by the CounterACT
Program, NIH Office of the Director, and the National Institute of
Allergy and Infectious Diseases, NIH/U.S. Army Medical Research and
Materiel Command interagency agreement no. Y1-OD-9611-01/A120-B.P2009-1
(G.A.R.).
NR 54
TC 12
Z9 13
U1 2
U2 28
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD MAY
PY 2013
VL 27
IS 5
BP 1928
EP 1938
DI 10.1096/fj.12-225037
PG 11
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 134PU
UT WOS:000318226100013
PM 23345455
ER
PT J
AU Wangchuk, S
Thapa, B
Zangmo, S
Jarman, RG
Bhoomiboonchoo, P
Gibbons, RV
AF Wangchuk, Sonam
Thapa, Binay
Zangmo, Sangay
Jarman, Richard G.
Bhoomiboonchoo, Piraya
Gibbons, Robert V.
TI Influenza surveillance from November 2008 to 2011; including pandemic
influenza A(H1N1)pdm09 in Bhutan
SO INFLUENZA AND OTHER RESPIRATORY VIRUSES
LA English
DT Article
DE Bhutan; H1N1; influenza; pandemic
ID A H1N1
AB Objective Describe the influenza A(H1N1) pandemic in Bhutan. Design Observational study from sentinel surveillance sites. Setting Bhutan remains isolated, with only one to two flights a day at the lone airport, no trains, and only three major roads that enter from India. Main outcome measures PCR positive human respiratory samples Results The first case of A(H1N1)pdm09 infection was detected in Bhutan in July 2009, 3 months after the virus was first reported in Mexico in April 2009. During the official WHO pandemic period (11 June 2009 to 8 August 2010), a total of 2149 samples were collected and tested by RT-PCR of which 22.7% (487) were confirmed A(H1N1)pdm09; H3N2, H1N1, and B were positive in 2.2%, 1.1%, and 7.2%, respectively. The highest rate of A(H1N1)pdm09 cases (57.4%) was detected in the 6-20 year-old age group. Importantly, Bhutan increased from 3 sentinel sites in April 2009 to 11 a year later, and in April 2010 established PCR capability for influenza. Conclusions Despite relative isolation, the A(H1N1)pdm09 reached Bhutan within 3 months of identification in Mexico. The H1N1 pandemic has made Bhutan more prepared for epidemics in the future.
C1 [Wangchuk, Sonam; Thapa, Binay; Zangmo, Sangay] Minist Hlth, Publ Hlth Lab, Dept Publ Hlth, Thimphu, Bhutan.
[Jarman, Richard G.; Bhoomiboonchoo, Piraya; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
RP Wangchuk, S (reprint author), Minist Hlth, Publ Hlth Lab, Dept Publ Hlth, Thimphu, Bhutan.
EM sonamphl@health.gov.bt
RI Valle, Ruben/A-7512-2013
NR 17
TC 3
Z9 3
U1 1
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1750-2640
J9 INFLUENZA OTHER RESP
JI Influenza Other Respir. Viruses
PD MAY
PY 2013
VL 7
IS 3
BP 426
EP 430
DI 10.1111/j.1750-2659.2012.00409.x
PG 5
WC Infectious Diseases; Virology
SC Infectious Diseases; Virology
GA 131XX
UT WOS:000318033100029
PM 22813389
ER
PT J
AU Abdissa, N
Induli, M
Akala, HM
Heydenreich, M
Midiwo, JO
Ndakala, A
Yenesew, A
AF Abdissa, Negera
Induli, Martha
Akala, Hoseah M.
Heydenreich, Matthias
Midiwo, Jacob O.
Ndakala, Albert
Yenesew, Abiy
TI Knipholone cyclooxanthrone and an anthraquinone dimer with
antiplasmodial activities from the roots of Kniphofia foliosa
SO PHYTOCHEMISTRY LETTERS
LA English
DT Article
DE Kniphofia foliosa; Asphodelaceae; Roots; Anthraquinone; Knipholone
cyclooxanthrone; 10-Methoxy-10,7 '-(chrysophanol anthrone)-chrysophanol;
Dianellin; Malaria
ID ANTHRONE; CONSTITUENTS; DERIVATIVES
AB A new phenylanthrone, named knipholone cyclooxanthrone and a dimeric anthraquinone, 10-methoxy-10,7'-(chrysophanol anthrone)-chrysophanol were isolated from the roots of Kniphofia foliosa together with the rare naphthalene glycoside, dianellin. The structures were determined by NMR and mass spectroscopic techniques. The compounds showed antiplasmodial activities against the chloroquine-resistant (W2) and chloroquine-sensitive (D6) strains of Plasmodium falciparum with 10-methoxy-10,7'-(chrysophanol anthrone)-chrysophanol being the most active with IC50 values of 1.17 +/- 0.12 and 4.07 +/- 1.54 mu g/ml, respectively. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.
C1 [Abdissa, Negera; Induli, Martha; Midiwo, Jacob O.; Ndakala, Albert; Yenesew, Abiy] Univ Nairobi, Dept Chem, Nairobi, Kenya.
[Induli, Martha] Makerere Univ, Dept Chem, Kampala, Uganda.
[Akala, Hoseah M.] USA, Med Res Unit Kenya, Walter Reed Project, Kisumu, AE 09831 USA.
[Heydenreich, Matthias] Univ Potsdam, Inst Chem, D-14415 Potsdam, Germany.
RP Yenesew, A (reprint author), Univ Nairobi, Dept Chem, POB 30197-00100, Nairobi, Kenya.
EM ayenesew@uonbi.ac.ke
OI Heydenreich, Matthias/0000-0003-1639-4959
FU German Academic Exchange Service (DAAD) through Natural Product Research
Network of Eastern and Central Africa (NAPRECA); International Science
Program (ISP, Sweden) [KEN-02]
FX Negera Abdissa acknowledges the German Academic Exchange Service (DAAD)
for the scholarship through Natural Product Research Network of Eastern
and Central Africa (NAPRECA). We thank Prof. Sebsebe Demissew of Botany
Department, Addis Ababa University for the identification of plant
material. Prof. G. Bringmann of Institute of Organic Chemistry,
University of Wurzburg is thanked for useful discussion. We are grateful
to International Science Program (ISP, Sweden) for research grant
(KEN-02).
NR 27
TC 4
Z9 4
U1 2
U2 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1874-3900
J9 PHYTOCHEM LETT
JI Phytochem. Lett.
PD MAY
PY 2013
VL 6
IS 2
BP 241
EP 245
DI 10.1016/j.phytol.2013.02.005
PG 5
WC Plant Sciences; Chemistry, Medicinal
SC Plant Sciences; Pharmacology & Pharmacy
GA 135EU
UT WOS:000318271400019
ER
PT J
AU Zinnert, JC
Via, SM
Young, DR
AF Zinnert, Julie C.
Via, Stephen M.
Young, Donald R.
TI Distinguishing natural from anthropogenic stress in plants: physiology,
fluorescence and hyperspectral reflectance
SO PLANT AND SOIL
LA English
DT Article
DE Drought; Salinity; RDX; TNT; Hyperspectral reflectance; Chlorophyll
fluorescence; Photosynthesis
ID CHLOROPHYLL FLUORESCENCE; WATER-STRESS; C-3 PLANTS;
HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE RDX; SALINITY; DROUGHT;
RESPONSES; TNT; PHOTOSYNTHESIS; VEGETATION
AB Explosives released into the environment from munitions production, processing facilities, or buried unexploded ordnances can be absorbed by surrounding roots and induce toxic effects in leaves and stems. Research into the mechanisms with which explosives disrupt physiological processes could provide methods for discrimination of anthropogenic and natural stresses. Our objectives were to experimentally evaluate the effects of natural stress and explosives on plant physiology and to link differences among treatments to changes in hyperspectral reflectance for possible remote detection.
Photosynthesis, water relations, chlorophyll fluorescence, and hyperspectral reflectance were measured following four experimental treatments (drought, salinity, trinitrotoluene and hexahydro-1,3,5-trinitro-l,3,5-triazine) on two woody species. Principal Components Analyses of physiological and hyperspectral results were used to evaluate the differences among treatments.
Explosives induced different physiological responses compared to natural stress responses. Stomatal regulation over photosynthesis occurred due to natural stress, influencing energy dissipation pathways of excess light. Photosynthetic declines in explosives were likely the result of metabolic dysfunction. Select hyperspectral indices could discriminate natural stressors from explosives using changes in the red and near-infrared spectral region.
These results show the possibility of using variations in energy dissipation and hyperspectral reflectance to detect plants exposed to explosives in a laboratory setting and are promising for field application using plants as phytosensors to detect explosives contamination in soil.
C1 [Zinnert, Julie C.] USA, Erdc, Fluorescence Spect Lab, Alexandria, VA 22315 USA.
[Zinnert, Julie C.; Via, Stephen M.; Young, Donald R.] Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA.
RP Zinnert, JC (reprint author), Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA.
EM jczinner@vcu.edu
OI Via, Stephen/0000-0002-4640-1673; Via, Stephen/0000-0002-6756-4156
FU U.S. Army Corps of Engineers/Engineer Research and Development Center
(ERDC); U.S. Army RDECOM ARL Army Research Office [W911NF-06-1-0074]
FX authors thank Jared Austin and Jarrod Edwards for assistance in data
collection. This research was supported by internal basic research
program funds from the U.S. Army Corps of Engineers/Engineer Research
and Development Center (ERDC) and (in part) by the U.S. Army RDECOM ARL
Army Research Office under grant W911NF-06-1-0074.
NR 43
TC 4
Z9 4
U1 1
U2 54
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0032-079X
J9 PLANT SOIL
JI Plant Soil
PD MAY
PY 2013
VL 366
IS 1-2
BP 133
EP 141
DI 10.1007/s11104-012-1414-1
PG 9
WC Agronomy; Plant Sciences; Soil Science
SC Agriculture; Plant Sciences
GA 131JG
UT WOS:000317988600011
ER
PT J
AU Cohen, SP
Bicket, MC
Jamison, D
Wilkinson, I
Rathmell, JP
AF Cohen, Steven P.
Bicket, Mark C.
Jamison, David
Wilkinson, Indy
Rathmell, James P.
TI Epidural Steroids A Comprehensive, Evidence-Based Review
SO REGIONAL ANESTHESIA AND PAIN MEDICINE
LA English
DT Review
ID LOW-BACK-PAIN; LUMBAR DISC HERNIATION; RANDOMIZED CONTROLLED-TRIAL;
2000-2010 TASK-FORCE; ACTIVE CONTROL TRIAL; CERVICAL TRANSFORAMINAL
INJECTION; POSTDURAL PUNCTURE HEADACHE; CENTRAL SPINAL STENOSIS; NERVE
ROOT COMPRESSION; CONTRAST FLOW PATTERNS
AB Epidural steroid injections (ESIs) are the most widely utilized pain management procedure in the world, their use supported by more than 45 placebo-controlled studies and dozens of systematic reviews. Despite the extensive literature on the subject, there continues to be considerable controversy surrounding their safety and efficacy. The results of clinical trials and review articles are heavily influenced by specialty, with those done by interventional pain physicians more likely to yield positive findings. Overall, more than half of controlled studies have demonstrated positive findings, suggesting a modest effect size lasting less than 3 months in well-selected individuals. Transforaminal injections are more likely to yield positive results than interlaminar or caudal injections, and subgroup analyses indicate a slightly greater likelihood for a positive response for lumbar herniated disk, compared with spinal stenosis or axial spinal pain. Other factors that may increase the likelihood of a positive outcome in clinical trials include the use of a nonepidural (eg, intramuscular) control group, higher volumes in the treatment group, and the use of depo-steroid. Serious complications are rare following ESIs, provided proper precautions are taken. Although there are no clinical trials comparing different numbers of injections, guidelines suggest that the number of injections should be tailored to individual response, rather than a set series. Most subgroup analyses of controlled studies show no difference in surgical rates between ESI and control patients; however, randomized studies conducted by spine surgeons, in surgically amenable patients with standardized operative criteria, indicate that in some patients the strategic use of ESI may prevent surgery. (Reg Anesth Pain Med 2013; 38: 175-200)
C1 [Cohen, Steven P.; Bicket, Mark C.] Johns Hopkins Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD USA.
[Cohen, Steven P.; Jamison, David] Walter Reed Natl Mil Med Ctr, Dept Anesthesiol, Pain Management Ctr, Bethesda, MD USA.
[Wilkinson, Indy] Womack Army Med Ctr, Dept Anesthesiol, Ft Bragg, NC USA.
[Rathmell, James P.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, MGH Pain Ctr, Boston, MA USA.
RP Cohen, SP (reprint author), 550 North Broadway,Suite 301, Baltimore, MD 21029 USA.
EM scohen40@jhmi.edu
FU Center for Rehabilitation Sciences Research, US Army
FX This work was funded in part by the Center for Rehabilitation Sciences
Research, US Army (to S.P.C.).
NR 316
TC 79
Z9 81
U1 1
U2 23
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1098-7339
EI 1532-8651
J9 REGION ANESTH PAIN M
JI Region. Anesth. Pain Med.
PD MAY-JUN
PY 2013
VL 38
IS 3
BP 175
EP 200
DI 10.1097/AAP.0b013e31828ea086
PG 26
WC Anesthesiology
SC Anesthesiology
GA 131BQ
UT WOS:000317966200003
PM 23598728
ER
PT J
AU Keefer, ML
Taylor, GA
Garletts, DF
Helms, CK
Gauthier, GA
Pierce, TM
Caudill, CC
AF Keefer, M. L.
Taylor, G. A.
Garletts, D. F.
Helms, C. K.
Gauthier, G. A.
Pierce, T. M.
Caudill, C. C.
TI HIGH-HEAD DAMS AFFECT DOWNSTREAM FISH PASSAGE TIMING AND SURVIVAL IN THE
MIDDLE FORK WILLAMETTE RIVER
SO RIVER RESEARCH AND APPLICATIONS
LA English
DT Article
DE entrainment; high-head dam; reservoir entrapment; turbine mortality;
Willamette River
ID SUMMER CHINOOK SALMON; COLUMBIA RIVER; JUVENILE SALMONIDS; SNAKE RIVER;
NONNATIVE FISHES; HYDROPOWER DAMS; FLOW; MORTALITY; RESERVOIRS; GROWTH
AB Many high-head dams in Oregon's Willamette River basin were constructed without fish passage facilities for downstream migrants. Instead, fish pass dams via hydroelectric turbines, surface spillways or deep-water regulating outlets. The availability of these routes varies seasonally with dam operations and reservoir depth, which can fluctuate by tens of meters. To assess how dam and reservoir operations affect fish movement timing and survival, we used rotary screw traps below three Willamette basin dams and at two riverine sites above reservoirs. Traps were operated 2950days over 8years, and >195000 fish were collected. Samples above reservoirs were primarily native salmonids (Oncorhynchus spp.), daces (Rhinichthys spp.) and sculpins (Cottus spp.), while those below dams were often dominated by non-native Centrarchidae. Capture rates at riverine sites were highest from late winter to early summer, coincident with juvenile Chinook salmon emigration. Conversely, collection below dams was largely restricted to late fall and winter when reservoirs were drawn down to annual lows and discharge was high. We hypothesize that winter operations facilitated fish access to dam turbines and regulating outlets, whereas springsummer operations entrapped fish in reservoirs and restricted volitional downstream passage. Total fish mortality was 2% at riverine sites and was 3669% below dams. Estimates were highest for non-native species and juvenile Chinook salmon. Fatal injuries were consistent with traumas related to pressure, shear and contact and there were size-related and morphology-related risk differences. Mitigation opportunities include fish bypass system development, retrofits for existing routes and seasonally appropriate reservoir draw down to allow fish passage. Copyright (c) 2012 John Wiley & Sons, Ltd.
C1 [Keefer, M. L.; Caudill, C. C.] Univ Idaho, Dept Fish & Wildlife Resources, Moscow, ID 83844 USA.
[Taylor, G. A.; Garletts, D. F.; Helms, C. K.; Gauthier, G. A.; Pierce, T. M.] USA, Corps Engineers, Lowell, OR USA.
RP Keefer, ML (reprint author), Univ Idaho, Dept Fish & Wildlife Resources, Moscow, ID 83844 USA.
EM mkeefer@uidaho.edu
RI Caudill, Christopher/M-7906-2014
FU US Army Corps of Engineers (USACE)
FX This work was funded by the US Army Corps of Engineers (USACE). We thank
the Willamette Hatchery staff, Oregon Department of Fish and Wildlife
(ODFW) biologists, USACE maintenance staff and the inter-agency Fish
Passage and Hatchery Management Committee for their assistance and
cooperation on this project, especially T. Wright, K. Kenaston, K. Reis
and J. Ziller. We also thank C. Lewellen and C. Murphy (USACE), and T.
Amandi and C. Banner (ODFW) for field assistance. D. Griffith (USACE)
provided project oversight and review.
NR 54
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U1 5
U2 47
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1535-1459
J9 RIVER RES APPL
JI River Res. Appl.
PD MAY
PY 2013
VL 29
IS 4
BP 483
EP 492
DI 10.1002/rra.1613
PG 10
WC Environmental Sciences; Water Resources
SC Environmental Sciences & Ecology; Water Resources
GA 131VT
UT WOS:000318026000006
ER
PT J
AU Neuman, MG
McKinney, KK
Nanau, RM
Kong, V
Malkiewicz, I
Mazulli, T
Moussa, G
Cohen, LB
AF Neuman, Manuela G.
McKinney, Kristi K.
Nanau, Radu M.
Kong, Vincent
Malkiewicz, Izabella
Mazulli, Tony
Moussa, George
Cohen, Lawrence B.
TI Drug-induced severe adverse reaction enhanced by human herpes virus-6
reactivation
SO TRANSLATIONAL RESEARCH
LA English
DT Article
ID INDUCED HYPERSENSITIVITY SYNDROME; STEVENS-JOHNSON-SYNDROME; TOXIC
EPIDERMAL NECROLYSIS; HEPATITIS-C-VIRUS; SOLUBLE FAS LIGAND;
INTERFERON-GAMMA RELEASE; HUMAN-HERPESVIRUS-6 REACTIVATION; HUMAN
HERPESVIRUS-6; ERYTHEMA MULTIFORME; SYSTEMIC SYMPTOMS
AB Reactivation of certain latent viruses has been linked with a more severe course of drug-induced hypersensitivity reaction (HSR). For example, reactivation of human herpes virus (HHV)-6 is associated with severe organ involvement and a prolonged course of disease. The present study discusses an HSR developed in a previously healthy male exposed to ceftriaxone, doxycycline, vancomycin, and trimethoprirn/sulfamethoxazole (co-trimoxazole; TMP/SMX). Initially, the patient presented clinical manifestations of HSR, as well as clinical and laboratory measurements compatible with liver and renal failure. Moreover, the patient presented skin desquamation compatible with Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis. During the reaction, it was observed HHV-6 reactivation. The severity of clinical symptoms is correlated with HHV-6 titer, as well as with results of the in vitro lymphocyte toxicity assay (LTA). Serum levels of a large panel of cytokines are compared between the patient, a large population of SJS patients, and a cohort of healthy controls, using data collected by our laboratory over the years. HHV-6 was measured in the cell culture media from lymphocytes incubated with each of the 4 drugs. Moreover, we describe a new assay using cytokines released by patient lymphocytes following in vitro exposure to the incriminated drugs as biomarkers of HSR. Based on LTA results, HHV-6 reactivation and cytokine measurements, we establish that only doxycycline and TMP/SMX were involved in the HSR. As result of this analysis, the patient could continue to use the other 2 antibiotics safely. (Translational Research 2013;161:430-440)
C1 In Vitro Drug Safety & Biotechnol, Toronto, ON, Canada.
Univ Toronto, Fac Med, Dept Pharmacol & Toxicol, Toronto, ON, Canada.
Univ Toronto, Fac Med, Inst Drug Res, Toronto, ON, Canada.
Walter Reed Army Med Ctr, Dept Allergy Immunol, Washington, DC 20307 USA.
Mt Sinai Hosp, Dept Microbiol, Toronto, ON M5G 1X5, Canada.
Univ Toronto, Dept Lab Med, Toronto, ON, Canada.
Sunnybrook Hlth Sci Ctr, Dept Gastroenterol, Toronto, ON M4N 3M5, Canada.
Univ Toronto, Dept Med, Toronto, ON, Canada.
RP Neuman, MG (reprint author), MaRS Discovery Dist, In Vitro Drug Safety & Biotechnol, 101 Coll St,South Tower,Suite 300,Lab 351, Toronto, ON M5G 1L7, Canada.
EM manuela.neuman@utoronto.ca
FU In Vitro Drug Safety and Biotechnology; HHV-6 Foundation (Santa Barbara,
CA)
FX The work was partially supported by a grant from In Vitro Drug Safety
and Biotechnology.; The authors thank the HHV-6 Foundation (Santa
Barbara, CA http://www.hhv-6foundation.org) for financial support and
Altona Diagnostics GmbH (Hamburg, Germany) for providing the kit for
HHV-6 genotype and viral load. The authors give special thanks to
Kristin Loomis (executive director of HHV-6 Foundation) for editorial
advice.
NR 117
TC 10
Z9 11
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1931-5244
J9 TRANSL RES
JI Transl. Res.
PD MAY
PY 2013
VL 161
IS 5
BP 430
EP 440
DI 10.1016/j.trsl.2012.12.012
PG 11
WC Medical Laboratory Technology; Medicine, General & Internal; Medicine,
Research & Experimental
SC Medical Laboratory Technology; General & Internal Medicine; Research &
Experimental Medicine
GA 133MM
UT WOS:000318142500007
PM 23333110
ER
PT J
AU Mal, S
Nori, S
Narayan, J
Prater, JT
Avasthi, DK
AF Mal, Siddhartha
Nori, Sudhakar
Narayan, J.
Prater, J. T.
Avasthi, D. K.
TI Ion-irradiation-induced ferromagnetism in undoped ZnO thin films
SO ACTA MATERIALIA
LA English
DT Article
DE Zinc oxide; Thin films; Pulsed laser deposition; Magnetic
semiconductors; Raman spectra
ID ZINC-OXIDE
AB We have introduced defects in ZnO epitaxial thin films by swift heavy Ag-107(9+) ion irradiation and investigated systematically their magnetic, electrical and optical properties. Oxygen annealed ZnO films are epitaxial single crystals that exhibit no long-range magnetic order. However, in this paper it is shown that room-temperature ferromagnetism (RTFM) can be introduced in a controlled manner in these films using ion irradiation and that the magnetization increases with ion dose. This qualitatively agrees with earlier studies which showed that RTFM could be induced in ZnO films through either vacuum thermal annealing or pulsed laser annealing below energy densities that lead to melting. Raman studies of the ion irradiated samples revealed dramatic changes in the vibration modes that correlated with increases in the carrier concentration, indicative of lattice disorder and defect creation. We compare these results with those observed in laser irradiated and vacuum annealed samples, and then discuss these findings in the context of defects and defect complexes created during the high-energy heavy ion irradiation process. We propose a unified mechanism to explain RTFM and n-type conductivity enhancements during irradiation, and laser and vacuum annealing. (c) 2012 Published by Elsevier Ltd. on behalf of Acta Materialia Inc.
C1 [Mal, Siddhartha; Nori, Sudhakar; Narayan, J.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA.
[Prater, J. T.] USA, Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA.
[Avasthi, D. K.] Inter Univ Accelerator Ctr, Mat Sci Grp, New Delhi 110067, India.
RP Mal, S (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA.
EM smal@ncsu.edu
RI Nori, Sudhakar/E-8111-2010; Avasthi, Devesh /D-4712-2013
NR 21
TC 18
Z9 18
U1 2
U2 43
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1359-6454
J9 ACTA MATER
JI Acta Mater.
PD MAY
PY 2013
VL 61
IS 8
SI SI
BP 2763
EP 2768
DI 10.1016/j.actamat.2012.09.071
PG 6
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA 128VL
UT WOS:000317797700005
ER
PT J
AU Jaqua, NT
Cunningham, S
Laczek, J
AF Jaqua, Nathan T.
Cunningham, Scott
Laczek, Jeffrey
TI An Unusual Cause of Rectal Hemorrhage in a Patient With Well-Controlled
Ulcerative Colitis Hemorrhage Related to an Ulcerated Colonic
Pseudopolyp
SO GASTROENTEROLOGY
LA English
DT Editorial Material
C1 [Jaqua, Nathan T.; Cunningham, Scott] Tripler Army Med Ctr, Dept Internal Med, Honolulu, HI 96859 USA.
[Laczek, Jeffrey] Tripler Army Med Ctr, Dept Gastroenterol, Honolulu, HI 96859 USA.
RP Jaqua, NT (reprint author), Tripler Army Med Ctr, Dept Internal Med, Honolulu, HI 96859 USA.
NR 3
TC 0
Z9 0
U1 0
U2 1
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0016-5085
J9 GASTROENTEROLOGY
JI Gastroenterology
PD MAY
PY 2013
VL 144
IS 5
BP E5
EP E6
DI 10.1053/j.gastro.2013.01.009
PG 2
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 129BR
UT WOS:000317813900003
PM 23523837
ER
PT J
AU Lin, YX
Wang, D
Donetsky, D
Shterengas, L
Kipshidze, G
Belenky, G
Svensson, SP
Sarney, WL
Hier, HS
AF Lin, Youxi
Wang, Ding
Donetsky, Dmitry
Shterengas, Leon
Kipshidze, Gela
Belenky, Gregory
Svensson, Stefan P.
Sarney, Wendy L.
Hier, Harry S.
TI Conduction- and Valence-Band Energies in Bulk InAs1-xSbx and Type II
InAs1-xSbx/InAs Strained-Layer Superlattices
SO JOURNAL OF ELECTRONIC MATERIALS
LA English
DT Article
DE InAsSb; SLS; energy-band offsets; bowing; broadening
ID BEAM EPITAXIAL-GROWTH; OPTICAL-PROPERTIES; ALLOYS; SEMICONDUCTORS; INSB;
GAP
AB The energy gaps were studied in two types of structures: unrelaxed bulk InAs1-x Sb (x) layers with x = 0.2 to 0.46 grown on metamorphic buffers and type II InAs1-x Sb (x) /InAs strained-layer superlattices (SLS) with x = 0.225 to 0.296 in the temperature range from T = 13 K to 300 K. All structures were grown on GaSb substrates. The longest wavelength of photoluminescence (PL) at low temperatures was observed from bulk InAs0.56Sb0.44 with a peak at 10.3 mu m and full-width at half-maximum (FWHM) of 11 meV. The PL data for the bulk InAs1-x Sb (x) materials of various compositions imply an energy gap bowing parameter of 0.87 eV. A low-temperature PL peak at 9.1 mu m with FWHM of 13 meV was observed for InAs0.704Sb0.296/InAs SLS. The PL spectrum of InAs0.775Sb0.225/InAs SLS under pulsed excitation revealed a second peak associated with recombination of electrons in the three-dimensional (3D) continuum with holes in the InAs0.775Sb0.225. This experiment determined the conduction-band offset in the InAs0.775Sb0.225/InAs SLS. The energies of the conduction and valence bands in unstrained InAs1-x Sb (x) and their bowing with respect to the Sb composition are discussed.
C1 [Lin, Youxi; Wang, Ding; Donetsky, Dmitry; Shterengas, Leon; Kipshidze, Gela; Belenky, Gregory] SUNY Stony Brook, Dept ECE, Stony Brook, NY 11794 USA.
[Svensson, Stefan P.; Sarney, Wendy L.; Hier, Harry S.] USA, Res Lab, Adelphi, MD 20783 USA.
RP Lin, YX (reprint author), SUNY Stony Brook, Dept ECE, Stony Brook, NY 11794 USA.
EM youxi.lin@stonybrook.edu
OI LIN, YOUXI/0000-0002-9092-2302
FU NSF [DMR1160843]; Army Research Office [62447EL]
FX The work was supported by NSF Grant DMR1160843 and Army Research Office
Contract 62447EL.
NR 29
TC 14
Z9 14
U1 7
U2 47
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0361-5235
J9 J ELECTRON MATER
JI J. Electron. Mater.
PD MAY
PY 2013
VL 42
IS 5
BP 918
EP 926
DI 10.1007/s11664-013-2528-9
PG 9
WC Engineering, Electrical & Electronic; Materials Science,
Multidisciplinary; Physics, Applied
SC Engineering; Materials Science; Physics
GA 131JD
UT WOS:000317988300024
ER
PT J
AU Nayak, SK
Singh, AK
Belegundu, AD
Yen, CF
AF Nayak, S. K.
Singh, A. K.
Belegundu, A. D.
Yen, C. F.
TI Process for design optimization of honeycomb core sandwich panels for
blast load mitigation
SO STRUCTURAL AND MULTIDISCIPLINARY OPTIMIZATION
LA English
DT Article
DE Honeycomb; Homogenization; Blast; Optimization; Sandwich plates; Virtual
testing
ID NUMERICAL-SIMULATION; SHAPE OPTIMIZATION; AIR BLAST; PLATES; BEHAVIOR
AB A general process for optimization of a sandwich panel to minimize the effects of air blast loading is presented here. The panel geometry consists of two metal face plates with a crushable honeycomb or other type of core. Optimization is necessary as there is strong coupling between the several variables and the physics, which makes parametric studies relatively ineffective. Virtual testing is used to develop a homogenized model for the stress-strain curve of the honeycomb core, which can be readily applied to other types of cellular core. The homogenized model has been validated by comparison to existing results as well as to results from detailed finite element (FE) models. A design of experiments (DOE) based response surface optimization method in combination with LS-DYNA is used to minimize dynamic deflection or acceleration of the back face plate. Constraints on total mass and on plastic strain in the face plates are imposed. The mechanism of lowering the backface deflection is by increasing front face plate thickness which effectively distributes the blast load to a larger area of the core and avoids local concave deformation of the front face plate. Further, core depth is increased which increases panel stiffness. For acceleration minimization, results again produce a stiffer front face plate, but accompanied by a sufficiently soft core. The mechanism of lowering the backface acceleration is by absorbing energy with low transmitted stress. A clear cut comparison between monolithic metal plates and sandwich plates, for the same loading and failure criteria, is presented here.
C1 [Nayak, S. K.; Singh, A. K.; Belegundu, A. D.] Penn State Univ, University Pk, PA 16802 USA.
[Nayak, S. K.] Brookhaven Natl Lab, Upton, NY 11973 USA.
[Yen, C. F.] USA, Res Lab, WRMD, Aberdeen Proving Ground, MD USA.
RP Belegundu, AD (reprint author), Penn State Univ, University Pk, PA 16802 USA.
EM adb3@psu.edu
FU Army Research Office [50490-EG]; High Performance Computing Group at
Penn State
FX This material is based upon work partly supported by the Army Research
Office, Proposal Number 50490-EG, monitored by Dr. Bruce LaMattina.
Partial financial and computational support from the High Performance
Computing Group at Penn State under Mr. Vijay Agarwala is gratefully
acknowledged.
NR 21
TC 3
Z9 3
U1 4
U2 47
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1615-147X
J9 STRUCT MULTIDISCIP O
JI Struct. Multidiscip. Optim.
PD MAY
PY 2013
VL 47
IS 5
BP 749
EP 763
DI 10.1007/s00158-012-0845-x
PG 15
WC Computer Science, Interdisciplinary Applications; Engineering,
Multidisciplinary; Mechanics
SC Computer Science; Engineering; Mechanics
GA 127FV
UT WOS:000317683800009
ER
PT J
AU Poropatich, R
Lai, E
McVeigh, F
Bashshur, R
AF Poropatich, Ronald
Lai, Eva
McVeigh, Francis
Bashshur, Rashid
TI The U.S. Army Telemedicine and m-Health Program: Making a Difference at
Home and Abroad
SO TELEMEDICINE AND E-HEALTH
LA English
DT Article
DE behavioral health; mobile health; cell phone; teleconsultation;
synchronous; asynchronous; telemedicine; telehealth; military
ID TRAUMATIC BRAIN-INJURY; TELEMENTAL HEALTH; SERVICE DELIVERY; MILITARY;
TECHNOLOGY
AB This article highlights the deployment of telemedicine by the U.S. Army through the various echelons of care and in overseas locations, including range and scope of health services provided by telemedicine in a challenging environment. This is followed by a discussion of technological developments advances in mobile communications likely to change the practice of telemedicine in the military from limited fixed-point access to a highly mobile individual with handheld communication devices.
C1 [Poropatich, Ronald; Lai, Eva; McVeigh, Francis] USA, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD USA.
[Poropatich, Ronald] Univ Pittsburgh, Ctr Mil Med Res, Pittsburgh, PA 15219 USA.
[Lai, Eva] Johns Hopkins Univ, Baltimore, MD USA.
[Bashshur, Rashid] Univ Michigan, Ann Arbor, MI 48109 USA.
RP Poropatich, R (reprint author), Univ Pittsburgh, Ctr Mil Med Res Hlth Sci, Bridgeside Point 2,Room 410 450 Technol Dr, Pittsburgh, PA 15219 USA.
EM rkp19@pitt.edu
NR 23
TC 12
Z9 12
U1 0
U2 11
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1530-5627
J9 TELEMED E-HEALTH
JI Telemed. e-Health
PD MAY
PY 2013
VL 19
IS 5
BP 380
EP 386
DI 10.1089/tmj.2012.0297
PG 7
WC Health Care Sciences & Services
SC Health Care Sciences & Services
GA 130FR
UT WOS:000317899200013
PM 23537383
ER
PT J
AU O'Hara, JA
McGann, P
Snesrud, EC
Clifford, RJ
Waterman, PE
Lesho, EP
Doi, Y
AF O'Hara, Jessica A.
McGann, Patrick
Snesrud, Erik C.
Clifford, Robert J.
Waterman, Paige E.
Lesho, Emil P.
Doi, Yohei
TI Novel 16S rRNA Methyltransferase RmtH Produced by Klebsiella pneumoniae
Associated with War-Related Trauma
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID RESISTANCE; SURVEILLANCE
AB Klebsiella pneumoniae strain MRSN2404 was isolated from the chronic wound of a soldier who had been wounded in Iraq in 2006. The strain displayed very high MICs of all aminoglycosides, including arbekacin. A gene encoding a novel 16S rRNA methyltransferase, now designated RmtH, was identified. RmtH had 64% identity with RmtB1 and RmtB2. rmtH was bracketed by two copies of ISCR2, which may have played a role in its mobilization.
C1 [O'Hara, Jessica A.; Doi, Yohei] Univ Pittsburgh, Sch Med, Div Infect Dis, Pittsburgh, PA 15260 USA.
[McGann, Patrick; Snesrud, Erik C.; Clifford, Robert J.; Waterman, Paige E.; Lesho, Emil P.] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD USA.
RP Doi, Y (reprint author), Univ Pittsburgh, Sch Med, Div Infect Dis, Pittsburgh, PA 15260 USA.
EM yod4@pitt.edu
FU U.S. Army Medical Command; Defense Medical Research and Development
Program; Department of Defense Global Emerging Infections Surveillance
and Response System (GEIS); Research Scholar Development Award; National
Institute of Allergy and Infectious Diseases [K22AI080584]
FX Major funding for the MRSN is provided by the U.S. Army Medical Command,
the Defense Medical Research and Development Program, and the Department
of Defense Global Emerging Infections Surveillance and Response System
(GEIS). Y.D. is supported in part through the Research Scholar
Development Award funded by the National Institute of Allergy and
Infectious Diseases (K22AI080584).
NR 18
TC 25
Z9 28
U1 0
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD MAY
PY 2013
VL 57
IS 5
BP 2413
EP 2416
DI 10.1128/AAC.00266-13
PG 4
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA 124ME
UT WOS:000317467600061
PM 23478957
ER
PT J
AU Zurawski, DV
Jacobs, AC
Thompson, MG
Palys, TJ
AF Zurawski, Daniel V.
Jacobs, Anna C.
Thompson, Mitchell G.
Palys, Thomas J.
TI Reply to "The Dual Personality of Iron Chelators: Growth Inhibitors or
Promoters?"
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Letter
ID BIOFILM; CELLS
C1 [Zurawski, Daniel V.; Jacobs, Anna C.; Thompson, Mitchell G.; Palys, Thomas J.] Walter Reed Army Inst Res, Dept Wound Infect, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA.
RP Zurawski, DV (reprint author), Walter Reed Army Inst Res, Dept Wound Infect, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA.
EM daniel.zurawski@amedd.army.mil
OI Zurawski, Daniel/0000-0002-7920-5601
NR 10
TC 1
Z9 1
U1 1
U2 11
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD MAY
PY 2013
VL 57
IS 5
BP 2434
EP 2434
DI 10.1128/AAC.00134-13
PG 1
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA 124ME
UT WOS:000317467600069
PM 23580580
ER
PT J
AU Bhattacharjee, AK
Pomponio, JW
Evans, SA
Pervitsky, D
Gordon, RK
AF Bhattacharjee, Apurba K.
Pomponio, James W.
Evans, Sarah A.
Pervitsky, Dmitry
Gordon, Richard K.
TI Discovery of subtype selective muscarinic receptor antagonists as
alternatives to atropine using in silico pharmacophore modeling and
virtual screening methods
SO BIOORGANIC & MEDICINAL CHEMISTRY
LA English
DT Article
DE In silico pharmacophore modeling; Virtual screening; Subtype selective;
Antimuscarinic agents; Atropine
ID ACETYLCHOLINE-RECEPTOR; DRUG DISCOVERY; OPPORTUNITIES; MANAGEMENT;
BLADDER; POTENT; MICE
AB Muscarinic acetylcholine receptors (mAChRs) have five known subtypes which are widely distributed in both the peripheral and central nervous system for regulation of a variety of cholinergic functions. Atropine is a well known muscarinic subtype non-specific antagonist that competitively inhibits acetylcholine (ACh) at postganglionic muscarinic sites. Atropine is used to treat organophosphate (OP) poisoning and resulting seizures in the warfighter because it competitively inhibits acetylcholine (ACh) at the muscarinic cholinergic receptors. ACh accumulates due to OP inhibition of acetylcholinesterase (AChE), the enzyme that hydrolyzes ACh. However, atropine produces several unwanted side-effects including dilated pupils, blurred vision, light sensitivity, and dry mouth. To overcome these side-effects, our goal was to find an alternative to atropine that emphasizes M1 (seizure prevention) antagonism but has minimum M2 (cardiac) and M3 (e. g., eye) antagonism so that an effective less toxic medical countermeasure may be developed to protect the warfighter against OP and other chemical warfare agents (CWAs). We adopted an in silico pharmacophore modeling strategy to develop features that are characteristics of known M1 subtype-selective compounds and used the model to identify several antagonists by screening an in-house (WRAIR-CIS) compound database. The generated model for the M1 selectivity was found to contain two hydrogen bond acceptors, one aliphatic hydrophobic, and one ring aromatic feature distributed in a 3D space. From an initial identification of about five hundred compounds, 173 compounds were selected through principal component and cluster analyses and in silico ADME/Toxicity evaluations. Next, these selected compounds were evaluated in a subtype-selective in vitro radioligand binding assay. Twenty eight of the compounds showed antimuscarinic activity. Nine compounds showed specificity for M1 receptors and low specificity for M3 receptors. The pK(i) values of the compounds range from 4.5 to 8.5 nM in comparison to a value of 8.7 nM for atropine. 2-(diethylamino)ethyl 2,2-diphenylpropanoate (ZW62841) was found have the best desired selectivity. None of the newly found compounds were previously reported to exhibit antimuscarinic specificity. Both theoretical and experimental results are presented. Published by Elsevier Ltd.
C1 [Bhattacharjee, Apurba K.; Pomponio, James W.; Evans, Sarah A.; Gordon, Richard K.] Walter Reed Army Inst Res, Dept Regulated Labs, Div Regulated Activ, Silver Spring, MD 20910 USA.
[Pervitsky, Dmitry] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA.
[Gordon, Richard K.] USA, Med Res & Mat Command, Ft Detrick, MD 21702 USA.
RP Bhattacharjee, AK (reprint author), Walter Reed Army Inst Res, Dept Regulated Labs, Div Regulated Activ, Silver Spring, MD 20910 USA.
EM apurba1995@yahoo.com; Richard.k.gordon@us.army.mil
FU DTRA [E0041_09_WR_C]
FX The opinions or assertions contained herein are the private views of the
authors and are not to be construed as official, or reflecting the views
of the Department of the Army or the Department of Defense. This work
was supported by the DTRA project No. E0041_09_WR_C.
NR 42
TC 6
Z9 6
U1 1
U2 45
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0968-0896
J9 BIOORGAN MED CHEM
JI Bioorg. Med. Chem.
PD MAY 1
PY 2013
VL 21
IS 9
BP 2651
EP 2662
DI 10.1016/j.bmc.2013.01.072
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry,
Organic
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
GA 123PS
UT WOS:000317403200023
PM 23523385
ER
PT J
AU Cohen, SP
Strassels, SA
Kurihara, C
Griffith, SR
Goff, B
Guthmiller, K
Hoang, HT
Morlando, B
Nguyen, C
AF Cohen, Steven Paul
Strassels, Scott A.
Kurihara, Connie
Griffith, Scott R.
Goff, Brandon
Guthmiller, Kevin
Hoang, Hieu T.
Morlando, Benny
Nguyen, Conner
TI Establishing an Optimal "Cutoff" Threshold for Diagnostic Lumbar Facet
Blocks A Prospective Correlational Study
SO CLINICAL JOURNAL OF PAIN
LA English
DT Article
DE facet joint; low back pain; predictive value; radiofrequency;
specificity; zygapophysial
ID LOW-BACK-PAIN; MEDIAL BRANCH BLOCKS; ZYGAPOPHYSIAL JOINT BLOCKS;
RADIOFREQUENCY DENERVATION; DOUBLE-BLIND; COST-EFFECTIVENESS;
RANDOMIZED-TRIAL; IMMPACT RECOMMENDATIONS; MULTICENTER ANALYSIS;
CLINICAL IMPORTANCE
AB Objectives: Diagnostic medial branch blocks (MBB) are considered the reference standard for diagnosing facetogenic pain and selecting patients for radiofrequency (RF) denervation. Great controversy exists regarding the ideal cutoff for designating a block as positive. The purpose of this study is to determine the optimal pain relief threshold for selecting patients for RF denervation after diagnostic MBB.
Methods: In this multicenter, prospective correlational study, 61 consecutive patients undergoing lumbar facet RF denervation after experiencing significant pain relief after MBB were enrolled. A positive outcome was defined as a >= 50% reduction in back pain at rest or with activity coupled with a positive satisfaction score lasting longer than 3 months. The relationship between pain relief after the blocks and denervation outcomes was evaluated by pairwise correlation matrix, receiver's operating characteristic curve, and stratifying outcomes based on 10- and 17-percentage point intervals for MBB.
Results: There were no significant differences in RF outcomes based on any MBB pain relief cutoff over 50%. A trend was noted whereby those patients who obtained <50% pain relief reported poorer outcomes. No optimal threshold for designating a diagnostic block as positive, above 50% pain relief, could be calculated.
Conclusion: Employing more stringent selection criteria for lumbar facet RF is likely to result in withholding a beneficial procedure from a substantial number of patients, without improving success rates.
C1 [Cohen, Steven Paul] Johns Hopkins Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD USA.
[Cohen, Steven Paul] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA.
[Kurihara, Connie; Morlando, Benny] Walter Reed Army Med Ctr, Dept Surg, Pain Management Div, Anesthesia Serv, Washington, DC USA.
[Griffith, Scott R.] Uniformed Serv Univ Hlth Sci, Walter Reed Army Med Ctr, Dept Anesthesiol, Bethesda, MD 20814 USA.
[Strassels, Scott A.] Univ Texas Austin, Div Pharm Practice, Austin, TX 78712 USA.
[Goff, Brandon] Uniformed Serv Univ Hlth Sci, Brooke Army Med Ctr, Dept Phys Med & Rehabil, San Antonio, TX USA.
[Guthmiller, Kevin; Hoang, Hieu T.] Brooke Army Med Ctr, Dept Anesthesiol, Ft Sam Houston, TX 78234 USA.
[Nguyen, Conner] Landstuhl Reg Med Ctr, Dept Surg, Phys Med & Rehabil Serv, Landstuhl, Germany.
RP Cohen, SP (reprint author), 550 North Broadway,Suite 301, Baltimore, MD 21029 USA.
EM scohen40@jhmi.edu
OI Goff, Brandon/0000-0002-5665-9395
FU John P. Murtha Neuroscience and Pain Institute, Johnstown, PA; US Army;
Army Regional Anesthesia & Pain Medicine Initiative, Washington, DC
FX Supported in part by a Congressional Grant from the John P. Murtha
Neuroscience and Pain Institute, Johnstown, PA; and the US Army; and the
Army Regional Anesthesia & Pain Medicine Initiative, Washington, DC. The
authors declare no conflicts of interest.
NR 59
TC 8
Z9 8
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0749-8047
J9 CLIN J PAIN
JI Clin. J. Pain
PD MAY
PY 2013
VL 29
IS 5
BP 382
EP 391
DI 10.1097/AJP.0b013e31825f53bf
PG 10
WC Anesthesiology; Clinical Neurology
SC Anesthesiology; Neurosciences & Neurology
GA 124QT
UT WOS:000317481300002
PM 23023310
ER
PT J
AU Dickinson, DP
Coleman, BG
Batrice, N
Lee, J
Koli, K
Pennington, C
Susin, C
Wikesjo, UME
AF Dickinson, Douglas P.
Coleman, Brandon G.
Batrice, Nathan
Lee, Jaebum
Koli, Komal
Pennington, Cathy
Susin, Cristiano
Wikesjoe, Ulf M. E.
TI Events of wound healing/regeneration in the canine supraalveolar
periodontal defect model
SO JOURNAL OF CLINICAL PERIODONTOLOGY
LA English
DT Article
DE cementum; critical-size defect; osteoid; periodontal ligament;
periodontal regeneration; reparative tissue; wound healing
ID MESENCHYMAL STEM-CELLS; GUIDED TISSUE REGENERATION; BARRIER MEMBRANES;
INTRABONY DEFECTS; REPAIR; DOGS; LIGAMENT; CEMENTOGENESIS; INDUCTION;
RATS
AB Aim The objective of this research was to elucidate early events in periodontal wound healing/regeneration using histological and immunohistochemical techniques. Methods Routine critical-size, supraalveolar, periodontal defects including a space-providing titanium mesh device were created in 12 dogs. Six animals received additional autologous blood into the defect prior to wound closure. One animal from each group was killed for analysis at 2, 5, 9, 14days, and at 4 and 8weeks. Results Both groups behaved similarly. Periodontal wound healing/regeneration progressed through three temporal phases. Early phase (25days): heterogeneous clot consolidation and cell activation in the periodontal ligament (PDL) and trabecular bone was associated with PDL regeneration and formation of a pre-osteoblast population. Intermediate phase (914days): cell proliferation (shown by PCNA immunostaining)/migration led to osteoid/bone, PDL and cementum formation. Late phase (48weeks): primarily characterized by tissue remodelling/maturation. Fibrous connective tissue from the gingival mucosa entered the wound early, competing with regeneration. By day 14, the wound space was largely filled with regenerative and reparative tissues. Conclusion Activation of cellular regenerative events in periodontal wound healing/regeneration is rapid; the general framework for tissue formation is broadly outlined within 14days. Most bone formation apparently originates from endosteally derived pre-osteoblasts; the PDL possibly acting as a supplementary source, with a primary function likely being regulatory/homeostatic. Blood accumulation at the surgical site warrants exploration; supplementation may be beneficial.
C1 [Dickinson, Douglas P.; Coleman, Brandon G.; Batrice, Nathan; Lee, Jaebum; Koli, Komal; Pennington, Cathy; Susin, Cristiano; Wikesjoe, Ulf M. E.] Georgia Regents Univ, Coll Dent Med, Lab Appl Periodontal & Craniofacial Regenerat, Augusta, GA USA.
[Dickinson, Douglas P.] Camellix LLC, Augusta, GA 30912 USA.
[Coleman, Brandon G.; Batrice, Nathan] USA, Adv Educ Program Periodont, Ft Gordon, GA USA.
RP Dickinson, DP (reprint author), Camellix LLC, 1120 15th St CA2149, Augusta, GA 30912 USA.
EM dougdickinson4357@gmail.com
RI Susin, Cristiano/B-9822-2008; Wikesjo, Ulf/A-4159-2009;
OI Wikesjo, Ulf/0000-0003-1607-0583; Coleman, Brandon/0000-0001-5799-303X
FU Georgia Regents University College of Dental Medicine Nobel Biocare
Center for Excellence [2008-764]; US Army Advanced Education Program in
Periodontics, Fort Gordon; Georgia Regents University College of Dental
Medicine; Nobel Biocare
FX This study was supported by an award (2008-764) to Dr. Douglas P
Dickinson from the Georgia Regents University College of Dental Medicine
Nobel Biocare Center for Excellence, periodontics residency training
grant awards to Drs. Brandon G Coleman and Nathan Batrice from the US
Army Advanced Education Program in Periodontics, Fort Gordon, and by the
Georgia Regents University College of Dental Medicine. Drs. Ulf ME
Wikesjo, Cristiano Susin, and Jaebum Lee are supported by grants to the
Laboratory for Applied Periodontal & Craniofacial Regeneration from
Nobel Biocare.
NR 32
TC 10
Z9 10
U1 1
U2 10
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-6979
J9 J CLIN PERIODONTOL
JI J. Clin. Periodontol.
PD MAY
PY 2013
VL 40
IS 5
BP 527
EP 541
DI 10.1111/jcpe.12055
PG 15
WC Dentistry, Oral Surgery & Medicine
SC Dentistry, Oral Surgery & Medicine
GA 122BN
UT WOS:000317290100010
PM 23461721
ER
PT J
AU Herbert, AS
Kuehne, AI
Barth, JF
Ortiz, RA
Nichols, DK
Zak, SE
Stonier, SW
Muhammad, MA
Bakken, RR
Prugar, LI
Olinger, GG
Groebner, JL
Lee, JS
Pratt, WD
Custer, M
Kamrud, KI
Smith, JF
Hart, MK
Dye, JM
AF Herbert, Andrew S.
Kuehne, Ana I.
Barth, James F.
Ortiz, Ramon A.
Nichols, Donald K.
Zak, Samantha E.
Stonier, Spencer W.
Muhammad, Majidat A.
Bakken, Russell R.
Prugar, Laura I.
Olinger, Gene G.
Groebner, Jennifer L.
Lee, John S.
Pratt, William D.
Custer, Max
Kamrud, Kurt I.
Smith, Jonathan F.
Hart, Mary Kate
Dye, John M.
TI Venezuelan Equine Encephalitis Virus Replicon Particle Vaccine Protects
Nonhuman Primates from Intramuscular and Aerosol Challenge with
Ebolavirus
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID HEMORRHAGIC-FEVER; MARBURG VIRUS; ALPHAVIRUS VECTORS; GUINEA-PIGS;
INFECTION; DISEASE; RNA; IMMUNIZATION; EXPRESSION; FAMILY
AB There are no vaccines or therapeutics currently approved for the prevention or treatment of ebolavirus infection. Previously, a replicon vaccine based on Venezuelan equine encephalitis virus (VEEV) demonstrated protective efficacy against Marburg virus in nonhuman primates. Here, we report the protective efficacy of Sudan virus (SUDV)- and Ebola virus (EBOV)-specific VEEV replicon particle (VRP) vaccines in nonhuman primates. VRP vaccines were developed to express the glycoprotein (GP) of either SUDV or EBOV. A single intramuscular vaccination of cynomolgus macaques with VRP expressing SUDV GP provided complete protection against intramuscular challenge with SUDV. Vaccination against SUDV and subsequent survival of SUDV challenge did not fully protect cynomolgus macaques against intramuscular EBOV back-challenge. However, a single simultaneous intramuscular vaccination with VRP expressing SUDV GP combined with VRP expressing EBOV GP did provide complete protection against intramuscular challenge with either SUDV or EBOV in cynomolgus macaques. Finally, intramuscular vaccination with VRP expressing SUDV GP completely protected cynomolgus macaques when challenged with aerosolized SUDV, although complete protection against aerosol challenge required two vaccinations with this vaccine.
C1 [Herbert, Andrew S.; Kuehne, Ana I.; Barth, James F.; Ortiz, Ramon A.; Nichols, Donald K.; Zak, Samantha E.; Stonier, Spencer W.; Muhammad, Majidat A.; Bakken, Russell R.; Prugar, Laura I.; Olinger, Gene G.; Groebner, Jennifer L.; Lee, John S.; Pratt, William D.; Hart, Mary Kate; Dye, John M.] USA, Med Res Inst Infect Dis, Frederick, MD USA.
[Custer, Max; Kamrud, Kurt I.; Smith, Jonathan F.] AlphaVax Inc, Res Triangle Pk, NC USA.
RP Dye, JM (reprint author), USA, Med Res Inst Infect Dis, Frederick, MD USA.
EM john.m.dye1@us.army.mil
RI sebastianovitsch, stepan/G-8507-2013;
OI Groebner, Jennifer/0000-0003-1503-5030; Olinger,
Gene/0000-0001-7338-0292; Lee, John/0000-0001-7605-1814
FU Defense Threat Reduction Agency [CBM.VAXPLAT.05.10.RD.005]
FX This study was kindly supported by the Defense Threat Reduction Agency
(project CBM.VAXPLAT.05.10.RD.005).
NR 48
TC 33
Z9 36
U1 1
U2 15
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD MAY
PY 2013
VL 87
IS 9
BP 4952
EP 4964
DI 10.1128/JVI.03361-12
PG 13
WC Virology
SC Virology
GA 123UK
UT WOS:000317416400016
PM 23408633
ER
PT J
AU McAlpin, TO
Savant, G
Brown, GL
Smith, SJ
Chapman, RS
AF McAlpin, Tate O.
Savant, Gaurav
Brown, Gary L.
Smith, S. Jarrell
Chapman, Raymond S.
TI Hydrodynamics of Knik Arm: Modeling Study
SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING
LA English
DT Article
DE Adaptive hydraulics; AdH; Anchorage; Numerical modeling of eddies; Knik
Arm; Cook Inlet; Cairn Point
ID COOK-INLET; COASTAL HEADLAND; EDDY FORMATION; ALASKA; MOVEMENT; WATER
AB An adaptive hydraulics (AdH) model was applied to lower Knik Arm near the Port of Anchorage, Alaska, to assess its ability to model a macrotidal system with complex hydrodynamics, including the formation and evolution of numerous gyres that are prominent at this site. Lower Knik Arm is an ideal system for this model evaluation because of the large tide range (approximately 10m at Anchorage) and complex geometry of the system, which results in high velocities and the formation of numerous eddies throughout the study area. One eddy of primary importance is the one generated by Cairn Point, which occurs near the Port of Anchorage. Limitations of previous modeling studies and the availability of recent field data enabled this evaluation. The AdH results were compared with field data (water surface elevations, fluxes, and velocities) collected in August of 2002 and 2006, and favorable comparisons obtained for tidal amplification and eddy generation indicate that AdH reasonably reproduces the complex hydrodynamic conditions in lower Knik Arm. Simulations were also performed to investigate the importance of eddy viscosity specification, frictional specification, and bathymetry on the generation/evolution of eddies present in the system. Upon completion of the model validation, simulations were performed with modified Cairn Point configurations to investigate the impact to the eddy generated at the port. These results illustrate the variation in eddy generation through lengthening, lowering/reducing, or raising Cairn Point. DOI: 10.1061/(ASCE)WW.1943-5460.0000171. (C) 2013 American Society of Civil Engineers.
C1 [McAlpin, Tate O.; Savant, Gaurav; Brown, Gary L.; Smith, S. Jarrell; Chapman, Raymond S.] USA, Coastal & Hydraul Lab, Corps Engineers, Vicksburg, MS 39180 USA.
[Savant, Gaurav] Dynam Solut LLC, Water Resources, Knoxville, TN 37919 USA.
RP McAlpin, TO (reprint author), USA, Coastal & Hydraul Lab, Corps Engineers, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM tate.o.mcalpin@usace.army.mil
FU U.S. Army Corp of Engineers Alaska District; U.S. Army Corp of Engineers
System Wide Water Resources Program (SWWRP)
FX The work described and results presented in this paper were obtained
through research sponsored by the U.S. Army Corp of Engineers Alaska
District and the U.S. Army Corp of Engineers System Wide Water Resources
Program (SWWRP). Permission to publish this paper was granted by the
Chief of Engineers, U.S. Army Corp of Engineers.
NR 47
TC 1
Z9 1
U1 0
U2 5
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0733-950X
EI 1943-5460
J9 J WATERW PORT COAST
JI J. Waterw. Port Coast. Ocean Eng.
PD MAY
PY 2013
VL 139
IS 3
BP 232
EP 246
DI 10.1061/(ASCE)WW.1943-5460.0000171
PG 15
WC Engineering, Civil; Engineering, Ocean; Water Resources
SC Engineering; Water Resources
GA 123WW
UT WOS:000317423400008
ER
PT J
AU Taflanidis, AA
Kennedy, AB
Westerink, JJ
Smith, J
Cheung, KF
Hope, M
Tanaka, S
AF Taflanidis, Alexandros A.
Kennedy, Andrew B.
Westerink, Joannes J.
Smith, Jane
Cheung, Kwok Fai
Hope, Mark
Tanaka, Seizo
TI Rapid Assessment of Wave and Surge Risk during Landfalling Hurricanes:
Probabilistic Approach
SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE
LA English
DT Article
DE Hurricane risk; Surge; Waves; Response surface surrogate modeling; Joint
probability method
ID RESPONSE FUNCTION-APPROACH; EMERGENCY MANAGEMENT; RUNUP; TRANSFORMATION;
OPTIMIZATION; BREAKING
AB A probabilistic framework is presented for evaluation of hurricane wave and surge risk with particular emphasis on real-time automated estimation for hurricanes approaching landfall. This framework has two fundamental components. The first is the development of a surrogate model for the rapid evaluation of hurricane waves, water levels, and run-up based on a small number of parameters describing each hurricane: hurricane landfall location and heading, central pressure, forward speed, and radius of maximum winds. This surrogate model is developed using a response surface methodology fed by information from hundreds of precomputed, high-resolution Simulating Waves Nearshore (SWAN) 1 Advanced Circulation Model for Oceanic, Coastal and Estuarine Waters (ADCIRC) and One-Dimensional Boussinesq Model (BOUSS-1D) runs. Fora specific set of hurricane parameters (i.e., a specific landfalling hurricane), the surrogate model is able to evaluate the maximum wave height, water level, and run-up during the storm at a cost that is more than seven orders of magnitude less than the high-fidelity models and thus meets time constraints imposed by emergency managers and decision makers. The second component of this framework is a description of the uncertainty in the parameters used to characterize the hurricane through appropriate probability models, which then leads to quantification of hurricane risk in terms of a probabilistic integral. This integral is then efficiently computed using the already established surrogate model by analyzing thousands of different scenarios (based on the aforementioned probabilistic description). This allows the rapid computation of, for example, the storm surge that might be exceeded 10% of the time based on hurricane parameters at 48 h from landfall. Finally, by leveraging the computational simplicity and efficiency of the surrogate model, a simple stand-alone PC-based risk-assessment tool is developed that allows nonexpert end users to take advantage of the full potential of the framework. The proposed framework ultimately facilitates the development of a rapid assessment tool for real-time implementation but requires a considerable upfront computational cost to produce high-fidelity model results. As an illustrative example, implementation of hurricane risk estimation for the Island of Oahu in Hawaii is presented; results demonstrate the versatility of the proposed approach for delivering accurate tools for real-time hurricane risk estimation that have the ability to cross over technology adoption barriers. DOI: 10.1061/(ASCE)WW.1943-5460.0000178. (C) 2013 American Society of Civil Engineers.
C1 [Taflanidis, Alexandros A.; Kennedy, Andrew B.; Westerink, Joannes J.; Hope, Mark] Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, Notre Dame, IN 46556 USA.
[Smith, Jane] USA, Corps Engineers, Ctr Res & Dev, Vicksburg, MS 39180 USA.
[Cheung, Kwok Fai] Univ Hawaii Manoa, Dept Ocean & Resources Engn, Honolulu, HI 96822 USA.
[Tanaka, Seizo] Univ Tokyo, Div Disaster Mitigat Sci, Bunkyo Ku, Tokyo 1130032, Japan.
RP Taflanidis, AA (reprint author), Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, Notre Dame, IN 46556 USA.
EM a.taflanidis@nd.edu
RI Kennedy, Andrew/E-4746-2011;
OI Kennedy, Andrew/0000-0002-7254-1346; Taflanidis,
Alexandros/0000-0002-9784-7480
FU U.S. Army Corps of Engineering [W912HZ-09-C-0086]
FX This research effort was supported by U.S. Army Corps of Engineering
Grant No. W912HZ-09-C-0086 under the Surge and Wave Island Modeling
Studies, Coastal Field Data Collection Program. This support is greatly
appreciated. Permission to publish this work was granted by the Chief of
Engineers, U. S. Army Corps of Engineers. The authors also thank Dr.
Rick Knabb, formerly of the Central Pacific Hurricane Center, for his
contribution in selecting the suite of hurricane scenarios used in this
study.
NR 44
TC 7
Z9 7
U1 2
U2 20
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0733-950X
J9 J WATERW PORT C-ASCE
JI J. Waterw. Port Coast. Ocean Eng.-ASCE
PD MAY
PY 2013
VL 139
IS 3
BP 171
EP 182
DI 10.1061/(ASCE)WW.1943-5460.0000178
PG 12
WC Engineering, Civil; Engineering, Ocean; Water Resources
SC Engineering; Water Resources
GA 123WW
UT WOS:000317423400003
ER
PT J
AU Darlington, DN
Craig, T
Gonzales, MD
Schwacha, MG
Cap, AP
Dubick, MA
AF Darlington, Daniel N.
Craig, Teresa
Gonzales, Mary D.
Schwacha, Martin G.
Cap, Andrew P.
Dubick, Michael A.
TI ACUTE COAGULOPATHY OF TRAUMA IN THE RAT
SO SHOCK
LA English
DT Article
DE Coagulation; polytrauma; hemorrhage; clotting firmness; platelets;
fibrinogen; PT; aPTT
ID ACTIVATED PROTEIN-C; PLATELET DYSFUNCTION; VASCULAR-RESISTANCE; COMBAT
CASUALTIES; BLOOD-VOLUME; HEMORRHAGE; RESUSCITATION; COAGULATION;
MORTALITY; INJURY
AB Introduction: Acute coagulopathy of trauma (aCOT) is a state of disordered coagulation developing soon after severe injury and blood loss and has been defined in the clinical literature as an elevation in prothrombin time (PT) and activated partial thromboplastin time (aPTT). Objective: The purpose of this study was to develop a rat model of aCOT resulting from polytrauma and hemorrhage and showing an elevation in PT and aPTT. Methods: Sprague-Dawley rats (300-400 g) were anesthetized with isoflurane. Polytrauma was induced by damaging 10 cm of small intestines, the right and medial liver lobes, the right leg skeletal muscle, and fracture of the right femur. Rats were hemorrhaged 40% of their estimated blood volume. No resuscitation was given. Venous and arterial blood samples were taken at times up to 4 h. Results: Polytrauma and hemorrhage resulted in a significant rise in PT, aPTT, potassium, lactate, and glucose. There was a significant decrease in plasma bicarbonate, base excess, and sodium. Blood urea nitrogen and creatinine rose steadily throughout the 4 h indicative of progressive renal failure. Hematocrit decreased significantly immediately after hemorrhage and trauma indicating a movement of fluid into the vascular space from extravascular sources, which was mirrored by a decrease in plasma fibrinogen concentration. In contrast, platelet count initially decreased, rose at 2 h, and decreased again at 3 to 4 h, indicating that platelets were released into the vascular space. The change in platelet count was mirrored by the changes in thrombin-antithrombin and plasmin-antiplasmin complexes. Rotational thromboelastometry showed complex changes. Clotting firmness fell initially, rose at 2 h, and fell again at 3 to 4 h similar to the changes in platelet count. alpha Angle was elevated, and clotting time was shortened over the 4 h. Treatment with cytochalasin D (platelet function inhibitor) eliminated the increases in clotting firmness and thrombin generation seen at 2 h with rising platelet count. Conclusions: This model of aCOT in rats showed complex changes in clotting parameters over 4 h that included a rise in PT and aPTT. At 4 h, there was a decrease in clotting firmness, even though the clot formation was faster (elevated ! angle and decrease in clotting time). The decrease in clotting firmness correlated with falling fibrinogen and platelet count. This model affords an opportunity to evaluate interventions in the treatment of aCOT.
C1 [Darlington, Daniel N.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA.
RP Darlington, DN (reprint author), USA, Inst Surg Res, 3650 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM daniel.darlington@amedd.army.mil
FU US Army Medical Research Materiel Command
FX Support for this study was received from the US Army Medical Research
Materiel Command.
NR 40
TC 24
Z9 24
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1073-2322
J9 SHOCK
JI Shock
PD MAY
PY 2013
VL 39
IS 5
BP 440
EP 446
DI 10.1097/SHK.0b013e31829040e3
PG 7
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA 127XE
UT WOS:000317731400007
PM 23481505
ER
PT J
AU Lin, LJ
Grimme, JM
Sun, J
Lu, SY
Gai, LS
Cropek, DM
Wang, YX
AF Lin, Li-Jung
Grimme, Jill M.
Sun, Jie
Lu, Shaoying
Gai, Lisa
Cropek, Donald M.
Wang, Yingxiao
TI The antagonistic roles of PDGF and integrin alpha v beta 3 in regulating
ROS production at focal adhesions
SO BIOMATERIALS
LA English
DT Article
DE Fluorescence resonance energy transfer (FRET); Focal adhesion (FA);
Integrin; Platelet derived growth factor (PDGF); Reactive oxygen species
(ROS)
ID ACTIN STRESS FIBERS; STEM-CELL FATE; ALPHA(V)BETA(3) INTEGRIN; MEMBRANE
PROTRUSION; SIGNAL-TRANSDUCTION; GROWTH-FACTORS; RAC; RHO; GTPASES;
ACTIVATION
AB Reactive oxygen species (ROS) have been shown to play crucial roles in regulating various cellular functions, e.g. focal adhesion (FA) dynamics and cell migration upon growth factor stimulation. However, it is not clear how ROS are regulated at subcellular FA sites to impact cell migration. We have developed a biosensor capable of monitoring ROS production at FA sites in live cells with high sensitivity and specificity, utilizing fluorescence resonance energy transfer (FRET). The results revealed that platelet derived growth factor (PDGF) can induce ROS production at FA sites, which is mediated by Rac1 activation. In contrast, integrins, specifically integrin alpha v beta 3, inhibits this local ROS production. The RhoA activity can mediate this inhibitory role of integrins in regulating ROS production. Therefore, PDGF and integrin alpha v beta 3 coordinate to have an antagonistic effect in the ROS production at FA sites to regulate cell adhesion and migration. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Lin, Li-Jung; Sun, Jie; Lu, Shaoying; Wang, Yingxiao] Univ Illinois, Dept Bioengn, Urbana, IL 61801 USA.
[Grimme, Jill M.; Cropek, Donald M.] USA, Corps Engineers, Construct Engn Res Lab, Champaign, IL 61822 USA.
[Gai, Lisa] Harvey Mudd Coll, Dept Engn, Claremont, CA 91711 USA.
[Wang, Yingxiao] Univ Illinois, Inst Genom Biol, Beckman Inst Adv Sci & Technol, Dept Mol & Integrat Physiol, Urbana, IL 61801 USA.
[Wang, Yingxiao] Univ Illinois, Inst Genom Biol, Beckman Inst Adv Sci & Technol, Neurosci Program, Urbana, IL 61801 USA.
[Wang, Yingxiao] Univ Illinois, Inst Genom Biol, Beckman Inst Adv Sci & Technol, Ctr Biophys & Computat Biol, Urbana, IL 61801 USA.
RP Wang, YX (reprint author), Univ Illinois, Dept Bioengn, Urbana, IL 61801 USA.
EM Donald.M.Cropek@usace.army.mil; yingxiao@illinois.edu
FU US Army Engineer Research and Development Center (ERDC) Broad Agency
Announcement (BAA); NIH [HL098472]; NSF [CBET0846429]; Beckman Laser
Institute, Inc.
FX We thank Steve Guo and Yue Zhuo for data analysis. This work is
supported in part by grants from the US Army Engineer Research and
Development Center (ERDC) Broad Agency Announcement (BAA) (Y.W. and
D.M.C.), NIH HL098472, NSF CBET0846429, and Beckman Laser Institute,
Inc. (Y.W.).
NR 48
TC 7
Z9 7
U1 0
U2 23
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0142-9612
J9 BIOMATERIALS
JI Biomaterials
PD MAY
PY 2013
VL 34
IS 15
BP 3807
EP 3815
DI 10.1016/j.biomaterials.2013.01.092
PG 9
WC Engineering, Biomedical; Materials Science, Biomaterials
SC Engineering; Materials Science
GA 120KH
UT WOS:000317168700008
PM 23465490
ER
PT J
AU Serge, SR
Priest, HA
Durlach, PJ
Johnson, CI
AF Serge, Stephen R.
Priest, Heather A.
Durlach, Paula J.
Johnson, Cheryl I.
TI The effects of static and adaptive performance feedback in game-based
training
SO COMPUTERS IN HUMAN BEHAVIOR
LA English
DT Article
DE Adaptive feedback; Game-based training; Instruction; Virtual
environments
ID COGNITIVE-LOAD; DISCOVERY; SPECIFICITY; ENVIRONMENT; KNOWLEDGE
AB Training in virtual environments (VEs) has the potential to establish mental models and task mastery while providing a safe environment in which to practice. Performance feedback is known to contribute to this learning; however, the most effective ways to provide feedback in VEs have not been established. The present study examined the effects of differing feedback content, focusing on adaptive feedback. Participants learned search procedures during multiple missions in a VE. A control group received only a performance score after each mission. Two groups additionally received either detailed or general feedback after each mission, while two other groups received feedback that adapted based on their performance (either detailed-to-general, or general-to-detailed). Groups that received detailed feedback from the start of training had faster performance improvement than all other groups; however, all feedback groups showed improved performance and by the fourth mission performed at levels above the control group. Results suggest that detailed feedback early in the training cycle is the most beneficial for the fastest learning of new task skills in VEs. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Serge, Stephen R.] Univ Cent Florida, Dept Psychol, Orlando, FL 32816 USA.
[Serge, Stephen R.] USA, Res Inst, Consortium Res Fellows Program, Orlando, FL 32826 USA.
[Priest, Heather A.; Durlach, Paula J.; Johnson, Cheryl I.] USA, Res Inst Behav & Social Sci, Orlando, FL 32826 USA.
RP Serge, SR (reprint author), Univ Cent Florida, Dept Psychol, POB 161390, Orlando, FL 32816 USA.
EM stephen-serge@us.army.mil; heather.priest@us.army.mil;
paula.durlach@us.army.mil; cheryl.i.johnson@us.army.mil
NR 35
TC 10
Z9 10
U1 7
U2 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0747-5632
J9 COMPUT HUM BEHAV
JI Comput. Hum. Behav.
PD MAY
PY 2013
VL 29
IS 3
BP 1150
EP 1158
DI 10.1016/j.chb.2012.10.007
PG 9
WC Psychology, Multidisciplinary; Psychology, Experimental
SC Psychology
GA 114UX
UT WOS:000316769300071
ER
PT J
AU Damarla, T
Bradley, M
Mehmood, A
Sabatier, JM
AF Damarla, Thyagaraju
Bradley, Marshall
Mehmood, Asif
Sabatier, James M.
TI Classification of Animals and People Ultrasonic Signatures
SO IEEE SENSORS JOURNAL
LA English
DT Article
DE Classification; micro-Doppler; support vector machine; ultrasonic sensor
AB Personnel detection using inexpensive nonimaging sensors is becoming increasingly important for several applications, namely, border surveillance, perimeter protection, and urban operations. In this paper, we explore the utility of ultrasonic sensors to distinguish between people and animals walking. We explore the phenomenology associated with human and animal walking and identify model-based features in the spectrogram. In particular, we study the properties of micro-Doppler returns from various body parts (limbs) of the people and animals to identify the features. Finally, we develop two algorithms for classifying people and animals using the micro-Doppler signatures: one algorithm for the case when the signal-to-noise ratio (SNR) is high and another for low SNR. A support vector machine and a Bayesian classifier were used to classify the targets when the SNR is low. We present the results of the algorithms applied to actual data collected at a horse farm.
C1 [Damarla, Thyagaraju] USA, Res Lab, Adelphi, MD 20783 USA.
[Bradley, Marshall] LogLinear Grp, Waveland, MS 39576 USA.
[Mehmood, Asif] USAF, Inst Technol, Wright Patterson AFB, OH 45433 USA.
[Sabatier, James M.] Univ Mississippi, Natl Ctr Phys Acoust, Oxford, MS 38655 USA.
RP Damarla, T (reprint author), USA, Res Lab, Adelphi, MD 20783 USA.
EM thyagaraju.damarla.civ@mail.mil; marshall.bradley@loglineargroup.com;
asif.mehmood.ctr@afit.edu; sabatier@oldmiss.edu
NR 23
TC 4
Z9 4
U1 0
U2 9
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1530-437X
J9 IEEE SENS J
JI IEEE Sens. J.
PD MAY
PY 2013
VL 13
IS 5
BP 1464
EP 1472
DI 10.1109/JSEN.2012.2236550
PG 9
WC Engineering, Electrical & Electronic; Instruments & Instrumentation;
Physics, Applied
SC Engineering; Instruments & Instrumentation; Physics
GA 118DV
UT WOS:000317003900013
ER
PT J
AU Martyr, RC
Dietrich, JC
Westerink, JJ
Kerr, PC
Dawson, C
Smith, JM
Pourtaheri, H
Powell, N
Van Ledden, M
Tanaka, S
Roberts, HJ
Westerink, HJ
Westerink, LG
AF Martyr, R. C.
Dietrich, J. C.
Westerink, J. J.
Kerr, P. C.
Dawson, C.
Smith, J. M.
Pourtaheri, H.
Powell, N.
Van Ledden, M.
Tanaka, S.
Roberts, H. J.
Westerink, H. J.
Westerink, L. G.
TI Simulating Hurricane Storm Surge in the Lower Mississippi River under
Varying Flow Conditions
SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE
LA English
DT Article
DE Storm surge; Mississippi River; Hurricanes; Rivers; Hydrodynamics;
Numerical models; Storm surge generation; Propagation and attenuation
ID SHALLOW-WATER EQUATIONS; SEDIMENT-TRANSPORT; SOUTHERN LOUISIANA; MODEL;
WAVE; PERFORMANCE; DISCHARGE; HINDCAST; STAGE; VALIDATION
AB Hurricanes in southeastern Louisiana develop significant surges within the lower Mississippi River. Storms with strong sustained easterly winds push water into shallow Breton Sound, overtop the river's east bank south of Pointe a la Hache, Louisiana, penetrate into the river, and are confined by levees on the west bank. The main channel's width and depth allow surge to propagate rapidly and efficiently up river. This work refines the high-resolution, unstructured mesh, wave current Simulating Waves Nearshore + Advanced Circulation (SWAN + ADCIRC) SL16 model to simulate river flow and hurricane-driven surge within the Mississippi River. A river velocity regime-based variation in bottom friction and a temporally variable riverine flow-driven radiation boundary condition are essential to accurately model these processes for high and/or time-varying flows. The coupled modeling system is validated for riverine flow stage relationships, flow distributions within the distributary systems, tides, and Hurricane Gustav (2008) riverine surges. DOI: 10.1061/(ASCE)HY.1943-7900.0000699. (C) 2013 American Society of Civil Engineers.
C1 [Martyr, R. C.; Westerink, J. J.; Kerr, P. C.; Westerink, H. J.; Westerink, L. G.] Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, Notre Dame, IN 46556 USA.
[Dietrich, J. C.; Dawson, C.] Univ Texas Austin, Inst Computat Engn & Sci, Austin, TX 78712 USA.
[Smith, J. M.] USA, Coastal Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Pourtaheri, H.; Powell, N.] USA, Corps Engineers, New Orleans, LA 70118 USA.
[Van Ledden, M.] Haskoning Nederland BV, Rotterdam, Netherlands.
[Tanaka, S.] Univ Tokyo, Earthquake Res Inst, Tokyo 1130032, Japan.
[Roberts, H. J.] ARCADIS INC, Boulder, CO 80301 USA.
RP Martyr, RC (reprint author), Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, Notre Dame, IN 46556 USA.
EM rmartyr@nd.edu
RI Dietrich, Joel/E-5161-2011
OI Dietrich, Joel/0000-0001-5294-2874
FU United States Army Corps of Engineers (USACE) New Orleans District
(MVN); USACE System-Wide Water Resources and Morphos Programs
FX This work was supported by the United States Army Corps of Engineers
(USACE) New Orleans District (MVN) and the USACE System-Wide Water
Resources and Morphos Programs. Computational resources and support were
provided by the University of Texas at Austin Texas Advanced Computing
Center (TACC). Permission to publish this paper was granted by the Chief
of Engineers, USACE.
NR 38
TC 8
Z9 10
U1 2
U2 31
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0733-9429
J9 J HYDRAUL ENG-ASCE
JI J. Hydraul. Eng.-ASCE
PD MAY
PY 2013
VL 139
IS 5
BP 492
EP 501
DI 10.1061/(ASCE)HY.1943-7900.0000699
PG 10
WC Engineering, Civil; Engineering, Mechanical; Water Resources
SC Engineering; Water Resources
GA 123XH
UT WOS:000317424700004
ER
PT J
AU Blyth, DM
Chung, KK
Cancio, LC
King, BT
Murray, CK
AF Blyth, Dana M.
Chung, Kevin K.
Cancio, Leopoldo C.
King, Booker T.
Murray, Clinton K.
TI Clinical utility of fungal screening assays in adults with severe burns
SO BURNS
LA English
DT Article
DE Burn; Fungal infection; Serology; beta-Glucan; Galactomannan
ID BETA-D-GLUCAN; INVASIVE ASPERGILLOSIS; WOUND-INFECTION; DIAGNOSIS;
COLONIZATION; ANTIGENEMIA; CULTURE
AB Background: Fungal wound infection is a leading cause of burn wound infections, and diagnosis is often delayed as it conventionally requires culture and histopathology. Fungal screening assays have sped diagnosis of invasive fungal infections in other populations. Few studies have evaluated the performance of fungal screening assays outside of the hematologic malignancy and hematopoietic stem cell transplant populations.
Methods: We performed a three year retrospective analysis of all fungal screening assays in burn patients in the ICU between 2008 and 2011. The primary goal was to evaluate the correlation between the two available fungal screening assays, (1 -> 3)-beta-D-glucan (BG) and galactomannan (GM) assay, and fungal wound colonization (FWC) and infection (FWI). We also evaluated previously hypothesized causes of false positives and their associations with false positives in the burn population.
Results: We identified 53 patients [median 29% total body surface area burned (TBSA), IQR 17-51] with BG or GM serological tests available, of which 15 had a FWI or FWC. FWC/FWI was associated with higher TBSA (p = 0.02). BG and GM correlated with TBSA (BG 0.57, p < 0.01; GM 0.35, p = 0.02), but neither assay was associated with FWI/FWC or species of fungus involved when FWI/FWC was diagnosed.
Conclusions: Positive BG and GM fungal screening assays are not associated with FWI/FWC, or with species of fungus when FWC/FWI is present. BG false positives are common and associated with higher TBSA burns. Published by Elsevier Ltd and ISBI
C1 [Blyth, Dana M.; Murray, Clinton K.] Brooke Army Med Ctr, San Antonio Mil Med Ctr, Houston, TX 78234 USA.
[Chung, Kevin K.; Cancio, Leopoldo C.; King, Booker T.] USA, Inst Surg Res, Houston, TX 78234 USA.
[Murray, Clinton K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
RP Murray, CK (reprint author), Brooke Army Med Ctr, Infect Dis Serv MCHE MDI, 3551 Roger Brooke Dr, Houston, TX 78234 USA.
EM clinton.murray@us.army.mil
OI Blyth, Dana/0000-0002-3917-7394
NR 19
TC 3
Z9 3
U1 1
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
J9 BURNS
JI Burns
PD MAY
PY 2013
VL 39
IS 3
BP 413
EP 419
DI 10.1016/j.burns.2012.08.009
PG 7
WC Critical Care Medicine; Dermatology; Surgery
SC General & Internal Medicine; Dermatology; Surgery
GA 118KX
UT WOS:000317025500006
PM 22999208
ER
PT J
AU Rizzo, JA
Burgess, P
Cartie, RJ
Prasad, BM
AF Rizzo, Julie A.
Burgess, Pamela
Cartie, Richard J.
Prasad, Balakrishna M.
TI Moderate systemic hypothermia decreases burn depth progression
SO BURNS
LA English
DT Article
DE Therapeutic hypothermia; Burn progression; Matrix metalloprotease;
Inflammation; Microarray
ID THERAPEUTIC HYPOTHERMIA; THERMAL-INJURY; MATRIX METALLOPROTEINASES;
INFLAMMATORY RESPONSE; PROFOUND HYPOTHERMIA; CEREBRAL-ISCHEMIA; LETHAL
HEMORRHAGE; MILD HYPOTHERMIA; UP-REGULATION; BRAIN-INJURY
AB Background: Therapeutic hypothermia has been proposed to be beneficial in an array of human pathologies including cardiac arrest, stroke, traumatic brain and spinal cord injury, and hemorrhagic shock. Burn depth progression is multifactorial but inflammation plays a large role. Because hypothermia is known to reduce inflammation, we hypothesized that moderate hypothermia will decrease burn depth progression.
Methods: We used a second-degree 15% total body surface area thermal injury model in rats. Burn depth was assessed by histology of biopsy sections. Moderate hypothermia in the range of 31-33 degrees C was applied for 4 h immediately after burn and in a delayed fashion, starting 2 h after burn. In order to gain insight into the beneficial effects of hypothermia, we analyzed global gene expression in the burned skin.
Results: Immediate hypothermia decreased burn depth progression at 6 h post injury, and this protective effect was sustained for at least 24 h. Burn depth was 18% lower in rats subjected to immediate hypothermia compared to control rats at both 6 and 24 h post injury. Rats in the delayed hypothermia group did not show any significant decrease in burn depth at 6 h, but had 23% lower burn depth than controls at 24 h. Increased expression of several skin-protective genes such as CCL4, CCL6 and CXCL13 and decreased expression of tissue remodeling genes such as matrix metalloprotease-9 were discovered in the skin biopsy samples of rats subjected to immediate hypothermia.
Conclusions: Systemic hypothermia decreases burn depth progression in a rodent model and up-regulation of skin-protective genes and down-regulation of detrimental tissue remodeling genes by hypothermia may contribute to its beneficial effects. Published by Elsevier Ltd and ISBI
C1 [Rizzo, Julie A.; Burgess, Pamela; Cartie, Richard J.; Prasad, Balakrishna M.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA.
RP Rizzo, JA (reprint author), MCHF SCL GSS, Ft Gordon, GA 30905 USA.
EM julie.rizzo@us.army.mil; pamela.burgess@us.army.mil;
rcartie@hotmail.com; balakrishna.prasad@us.army.mil
NR 43
TC 5
Z9 5
U1 0
U2 11
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
J9 BURNS
JI Burns
PD MAY
PY 2013
VL 39
IS 3
BP 436
EP 444
DI 10.1016/j.burns.2012.07.022
PG 9
WC Critical Care Medicine; Dermatology; Surgery
SC General & Internal Medicine; Dermatology; Surgery
GA 118KX
UT WOS:000317025500009
PM 23149435
ER
PT J
AU Richard, R
Dewey, S
Parry, I
Jones, J
AF Richard, Reg
Dewey, Scott
Parry, Ingrid
Jones, John
TI Untitled
SO BURNS
LA English
DT Letter
ID CONTRACTURES; MANAGEMENT
C1 [Richard, Reg; Dewey, Scott; Jones, John] USA, Inst Surg Res, Burn Ctr, San Antonio, TX USA.
[Parry, Ingrid] Shriners Hosp Children Northern Calif, Sacramento, CA USA.
RP Richard, R (reprint author), USA, Inst Surg Res, ATTN MCMR SRT T Richard, 3698 Chambers Pass,Bldg 3611, Ft Sam Houston, TX 78234 USA.
EM reginald.richard@amedd.army.mil
NR 4
TC 1
Z9 1
U1 0
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
J9 BURNS
JI Burns
PD MAY
PY 2013
VL 39
IS 3
BP 539
EP 541
DI 10.1016/j.burns.2012.07.032
PG 3
WC Critical Care Medicine; Dermatology; Surgery
SC General & Internal Medicine; Dermatology; Surgery
GA 118KX
UT WOS:000317025500033
PM 23107355
ER
PT J
AU Romero-Zurita, N
McLernon, D
Ghogho, M
Swami, A
AF Romero-Zurita, Nabil
McLernon, Des
Ghogho, Mounir
Swami, Ananthram
TI PHY Layer Security Based on Protected Zone and Artificial Noise
SO IEEE SIGNAL PROCESSING LETTERS
LA English
DT Article
DE Artificial noise; beamforming; outage probability; passive
eavesdropping; physical layer security; protected zone; secrecy rate;
wireless secrecy
AB We address physical layer security in multiple-input-multiple-output (MISO) communications in the presence of an unknown passive eavesdropper. Beamforming and artificial noise broadcasting are chosen to increase communications security. We first study the effect of a close eavesdropper on security and then we define a "Protected Zone" in the transmitter's vicinity. We present an optimisation strategy that intelligently sets the transmission power and the size of the protected zone to probabilistically achieve secrecy at a specified target secrecy rate. The results show that this strategy can achieve a high probability of secrecy by efficiently prioritising the use of the available resources.
C1 [Romero-Zurita, Nabil; McLernon, Des; Ghogho, Mounir] Univ Leeds, Sch Elect & Elect Engn, Leeds LS2 9JT, W Yorkshire, England.
[Ghogho, Mounir] Int Univ Rabat, Rabat, Morocco.
[Swami, Ananthram] USA, Res Lab, Adelphi, MD 20783 USA.
RP Romero-Zurita, N (reprint author), Univ Leeds, Sch Elect & Elect Engn, Leeds LS2 9JT, W Yorkshire, England.
EM el08lnrz@leeds.ac.uk; d.c.mclernon@leeds.ac.uk; m.ghogho@leeds.ac.uk;
a.swami@ieee.org
RI Romero-Zurita, Nabil/E-5790-2012
OI Romero-Zurita, Nabil/0000-0002-0060-3122
NR 7
TC 19
Z9 21
U1 0
U2 8
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1070-9908
J9 IEEE SIGNAL PROC LET
JI IEEE Signal Process. Lett.
PD MAY
PY 2013
VL 20
IS 5
BP 487
EP 490
DI 10.1109/LSP.2013.2252898
PG 4
WC Engineering, Electrical & Electronic
SC Engineering
GA 118FA
UT WOS:000317007600001
ER
PT J
AU Shih, TM
Koplovitz, I
McDonough, JH
Myers, TM
Kan, RK
AF Shih, T. M.
Koplovitz, I.
McDonough, J. H.
Myers, T. M.
Kan, R. K.
TI Tertiary oximes on acetylcholinesterase activity, survival, and
neurobehavioral consequences following nerve agent exposure
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Meeting Abstract
CT 24th Biennial Meeting of the International-Society-for-Neurochemistry
and the American-Society-for-Neurochemistry
CY APR 20-24, 2013
CL Cancun, MEXICO
SP Int Soc Neurochemistry, Amer Soc Neurochemistry
C1 [Shih, T. M.; Koplovitz, I.; McDonough, J. H.; Myers, T. M.; Kan, R. K.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
NR 0
TC 0
Z9 0
U1 1
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3042
J9 J NEUROCHEM
JI J. Neurochem.
PD MAY
PY 2013
VL 125
SU 1
SI SI
BP 272
EP 273
PG 2
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 117OB
UT WOS:000316961700640
ER
PT J
AU Gao, XG
Lin, HL
Ray, R
Ray, P
AF Gao, Xiugong
Lin, Hsiuling
Ray, Radharaman
Ray, Prabhati
TI Toxicogenomic Studies of Human Neural Cells Following Exposure to
Organophosphorus Chemical Warfare Nerve Agent VX
SO NEUROCHEMICAL RESEARCH
LA English
DT Article
DE Organophosphorus compound; Chemical warfare agent; Nerve agent; VX;
Neural cells; Neurotoxicity; Microarray
ID HUNTINGTONS-DISEASE; ALZHEIMERS-DISEASE; GENE-EXPRESSION; IMMUNOLOGICAL
ABNORMALITIES; NEUROTROPHIC FACTOR; REDUCED EXPRESSION; SIGNALING
PATHWAY; SEMAPHORIN 3A; BRAIN; SCHIZOPHRENIA
AB Organophosphorus (OP) compounds represent an important group of chemical warfare nerve agents that remains a significant and constant military and civilian threat. OP compounds are considered acting primarily via cholinergic pathways by binding irreversibly to acetylcholinesterase, an important regulator of the neurotransmitter acetylcholine. Many studies over the past years have suggested that other mechanisms of OP toxicity exist, which need to be unraveled by a comprehensive and systematic approach such as genome-wide gene expression analysis. Here we performed a microarray study in which cultured human neural cells were exposed to 0.1 or 10 mu M of VX for 1 h. Global gene expression changes were analyzed 6, 24, and 72 h post exposure. Functional annotation and pathway analysis of the differentially expressed genes has revealed many genes, networks and canonical pathways that are related to nervous system development and function, or to neurodegenerative diseases such as Alzheimer's disease, Huntington's disease, and Parkinson's disease. In particular, the neuregulin pathway impacted by VX exposure has important implications in many nervous system diseases including schizophrenia. These results provide useful information valuable in developing suitable antidotes for more effective prevention and treatment of, as well as in developing biomarkers for, VX-induced chronic neurotoxicity.
C1 [Gao, Xiugong; Lin, Hsiuling; Ray, Prabhati] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA.
[Ray, Radharaman] USA, Div Res, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
RP Ray, P (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM xiugong.gao@amedd.army.mil; hsiuling.lin@us.army.mil;
radharman.ray@us.army.mil; prabhati.ray@us.army.mil
FU Defense Threat Reduction Agency (DTRA) [CBS.MEDCHEM.01.10.WR.005]
FX We thank Dr. Maryanne T. Vahey and her staff of the WRAIR Vaccine
Genomics Laboratory (Rockville, MD), Mr. Martin E. Nau and Dr. Zhining
Wang, for their kind help in performing the microarray experiments and
providing the raw data. We also thank Ms. Betty J. Benton and Dr. Brian
M Keyser at USAMRICD for their help with VX exposure, and Mr. Jack
Amnuaysirikul at WRAIR for his help with RNA sample preparation. This
work was supported by the Defense Threat Reduction Agency (DTRA) Project
No. CBS.MEDCHEM.01.10.WR.005. The opinions or assertions contained
herein are the private views of the authors and are not to be construed
as official or as reflecting true views of the US Army or the Department
of Defense.
NR 81
TC 1
Z9 1
U1 2
U2 44
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-3190
J9 NEUROCHEM RES
JI Neurochem. Res.
PD MAY
PY 2013
VL 38
IS 5
BP 916
EP 934
DI 10.1007/s11064-013-0996-1
PG 19
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 116SO
UT WOS:000316903200003
PM 23440544
ER
PT J
AU Bessho, T
Morii, S
Kusumoto, T
Shinohara, T
Noda, M
Uchiyama, S
Shuto, S
Nishimura, S
Djikeng, A
Duszenko, M
Martin, SK
Inui, T
Kubata, KB
AF Bessho, Tomoaki
Morii, Shoko
Kusumoto, Toshihide
Shinohara, Takahiro
Noda, Masanori
Uchiyama, Susumu
Shuto, Satoshi
Nishimura, Shigenori
Djikeng, Appolinaire
Duszenko, Michael
Martin, Samuel K.
Inui, Takashi
Kubata, Kilunga B.
TI Characterization of the novel Trypanosoma brucei inosine 5
'-monophosphate dehydrogenase
SO PARASITOLOGY
LA English
DT Article
DE trypanosome; enzyme kinetics; enzyme inhibitor; nucleoside nucleotide
analogues; drug design
ID HUMAN AFRICAN TRYPANOSOMIASIS; TRANSITION-STATE ANALOG; HEPATITIS-C
VIRUS; MONOPHOSPHATE DEHYDROGENASE; TRITRICHOMONAS-FETUS; IMP
DEHYDROGENASE; CRYSTAL-STRUCTURE; ANTIVIRAL ACTIVITY; KINETIC MECHANISM;
DRUG DESIGN
AB There is an alarming rate of human African trypanosomiasis recrudescence in many parts of sub-Saharan Africa. Yet, the disease has no successful chemotherapy. Trypanosoma lacks the enzymatic machinery for the de novo synthesis of purine nucleotides, and is critically dependent on salvage mechanisms. Inosine 5'-monophosphate dehydrogenase (IMPDH) is responsible for the rate-limiting step in guanine nucleotide metabolism. Here, we characterize recombinant Trypanosoma brucei IMPDH (TbIMPDH) to investigate the enzymatic differences between TbIMPDH and host IMPDH. Size-exclusion chromatography and analytical ultracentrifugation sedimentation velocity experiments reveal that TbIMPDH forms a heptamer, different from type 1 and 2 mammalian tetrameric IMPDHs. Kinetic analysis reveals calculated K-m values of 30 and 1300 mu M for IMP and NAD, respectively. The obtained K-m value of TbIMPDH for NAD is approximately 20-200-fold higher than that of mammalian enzymes and indicative of a different NAD binding mode between trypanosomal and mammalian IMPDHs. Inhibition studies show K-i values of 3.2 mu M, 21 nM and 3.3 nM for ribavirin 5'-monophosphate, mycophenolic acid and mizoribine 5'-monophosphate, respectively. Our results show that TbIMPDH is different from its mammalian counterpart and thus may be a good target for further studies on anti-trypanosomal drugs.
C1 [Bessho, Tomoaki; Morii, Shoko; Kusumoto, Toshihide; Shinohara, Takahiro; Nishimura, Shigenori; Inui, Takashi] Osaka Prefecture Univ, Lab Biol Macromol, Grad Sch Life & Environm Sci, Naka Ku, Sakai, Osaka 5998531, Japan.
[Noda, Masanori; Uchiyama, Susumu] Osaka Univ, Grad Sch Engn, Dept Biotechnol, Suita, Osaka 5650871, Japan.
[Shuto, Satoshi] Hokkaido Univ, Fac Pharmaceut Sci, Lab Organ Chem Drug Dev, Kita Ku, Sapporo, Hokkaido 0600812, Japan.
[Djikeng, Appolinaire] Int Livestock Res Inst ILRI, Biosci Eastern & Cent Africa BecA Hub, Nairobi, Kenya.
[Djikeng, Appolinaire] JCVI, Rockville, MD 20876 USA.
[Duszenko, Michael] Univ Tubingen, Interfac Inst Biochem, D-72076 Tubingen, Germany.
[Martin, Samuel K.] USA, Med Res Unit Kenya, Unit 64109, APO, AE 09831 USA.
[Kubata, Kilunga B.] AU NEPAD Agcy Reg Off Eastern & Cent Africa, Nairobi, Kenya.
RP Inui, T (reprint author), Osaka Prefecture Univ, Lab Biol Macromol, Grad Sch Life & Environm Sci, Naka Ku, 1-1 Gakuen Cho, Sakai, Osaka 5998531, Japan.
EM inuit@bioinfo.osakafu-u.ac.jp; bkkubata@nepadst.org
RI Inui, Takashi/G-1069-2011
FU Government of Canada through the Canadian International Development
Agency; Ministry of Education, Culture, Sports, Science and Technology
of Japan; Osaka Prefecture [17300165, 21500428, 21200076]
FX We thank Dr K. Fujimori, Ms M. Tabuchi and Ms C. Kimura for technical
assistance and helpful discussions. This study was undertaken with the
financial support of the Government of Canada provided through the
Canadian International Development Agency to NEPAD. This study was also
supported in part by the program Grants-in-Aid for Scientific Research
of the Ministry of Education, Culture, Sports, Science and Technology of
Japan and Osaka Prefecture (grant numbers 17300165, 21500428 and
21200076 (to T.I.)).
NR 51
TC 3
Z9 3
U1 1
U2 20
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0031-1820
EI 1469-8161
J9 PARASITOLOGY
JI Parasitology
PD MAY
PY 2013
VL 140
IS 6
BP 735
EP 745
DI 10.1017/S0031182012002090
PG 11
WC Parasitology
SC Parasitology
GA 115MJ
UT WOS:000316816000007
PM 23369253
ER
PT J
AU Hollingshad, NW
Svenkeson, A
West, BJ
Grigolini, P
AF Hollingshad, Nicholas W.
Svenkeson, Adam
West, Bruce J.
Grigolini, Paolo
TI Time to consensus
SO PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
LA English
DT Article
DE Networks; Criticality; First passage time; Complex systems;
Decision-making
ID CRITICALITY; NETWORKS; MODEL
AB The dynamics of a two-state decision-making model (DMM) with a tunable control parameter K is described. On all-to-all (ATA) networks, the system undergoes a phase transition at a critical value of K-c = 1. Scale-free networks were also found to undergo phase transitions, but the value of K-c increases as the scale-free exponent increases. Time to consensus is defined as a first passage time to a specified threshold of the global mean field, which represents a level of majority for the network. At criticality, the time to consensus for sparse networks with broad degree distributions (e.g., scale-free networks) approaches that of the ATA networks, although somewhat more cooperation (higher K-c) is required. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Hollingshad, Nicholas W.; Svenkeson, Adam; Grigolini, Paolo] Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA.
[West, Bruce J.] USA, Informat Sci Directorate, Res Off, Durham, NC 27709 USA.
RP Hollingshad, NW (reprint author), Univ N Texas, Ctr Nonlinear Sci, POB 311427, Denton, TX 76203 USA.
EM nhollingshad@verizon.net
FU ARO [W911NF1110478]; Welch [B-1577]
FX N. W. Hollingshad, A. Svenkeson and P. Grigolini warmly thank ARO and
Welch for financial support through Grants W911NF1110478 and B-1577,
respectively.
NR 25
TC 2
Z9 2
U1 1
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-4371
J9 PHYSICA A
JI Physica A
PD MAY 1
PY 2013
VL 392
IS 9
BP 2302
EP 2310
DI 10.1016/j.physa.2013.01.037
PG 9
WC Physics, Multidisciplinary
SC Physics
GA 114WX
UT WOS:000316774800039
ER
PT J
AU Coppock, M
Farrow, B
Finch, AS
Lai, B
Maciel, J
Heath, J
Stratis-Cullum, DN
AF Coppock, M.
Farrow, B.
Finch, A. S.
Lai, B.
Maciel, J.
Heath, J.
Stratis-Cullum, D. N.
TI Protein Capture Agents with High Affinity, Selectivity, and Stability
for Improving BioDetection Assays
SO BIOPOLYMERS
LA English
DT Meeting Abstract
CT 23rd American Peptide Symposium
CY JUN 22-27, 2013
CL Waikoloa, HI
C1 [Coppock, M.; Finch, A. S.; Stratis-Cullum, D. N.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
[Farrow, B.; Heath, J.] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA.
[Lai, B.] Integrated Diagnost, Culver City, CA 90230 USA.
[Maciel, J.] Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
NR 0
TC 1
Z9 1
U1 2
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0006-3525
EI 1097-0282
J9 BIOPOLYMERS
JI Biopolymers
PD MAY
PY 2013
VL 100
IS 3
SI SI
BP 289
EP 289
PG 1
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA AI0IL
UT WOS:000336530200237
ER
PT J
AU Gaidamakova, E
Myles, I
McDaniel, D
Gayen, M
Gupta, P
Sharma, A
Glass, P
Maheshwari, R
Datta, S
Daly, MJ
AF Gaidamakova, Elena
Myles, Ian
McDaniel, Dennis
Gayen, Manoshi
Gupta, Paridhi
Sharma, Anuj
Glass, Pamela
Maheshwari, Radha
Datta, Sandip
Daly, Michael J.
TI Applying a Radioprotective Mn(II)-peptide-Pi Complex to the Preparation
of Irradiated Vaccines
SO BIOPOLYMERS
LA English
DT Meeting Abstract
CT 23rd American Peptide Symposium
CY JUN 22-27, 2013
CL Waikoloa, HI
C1 [Gaidamakova, Elena; McDaniel, Dennis; Gayen, Manoshi; Gupta, Paridhi; Sharma, Anuj; Maheshwari, Radha; Daly, Michael J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Myles, Ian; Datta, Sandip] NIAID, Bethesda, MD 20892 USA.
[Glass, Pamela] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0006-3525
EI 1097-0282
J9 BIOPOLYMERS
JI Biopolymers
PD MAY
PY 2013
VL 100
IS 3
SI SI
BP 297
EP 297
PG 1
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA AI0IL
UT WOS:000336530200269
ER
PT J
AU Tannheimer, M
Buzzelli, MD
Albertini, N
Lechner, R
Ulmer, HV
Engelhardt, M
AF Tannheimer, Markus
Buzzelli, Mark D.
Albertini, Nadine
Lechner, Raimund
Ulmer, Hans-V
Engelhardt, Michael
TI Improvement in Altitude Performance Test After Further Acclimatization
in Pre-Acclimatized Soldiers
SO MILITARY MEDICINE
LA English
DT Article
AB The Altitude Performance Test is a measure designed to assess an individual's degree of acclimatization to reduce the risk of acute mountain sickness during high-altitude activities. The aim of this study was to investigate the hypothesis that test results will improve in pre-acclimatized soldiers after several days of further acclimatization. The Altitude Performance Test consists of an uphill run at high altitude. The event is timed and performed with continuous oxygen saturation (SpO(2)) monitoring. The individual's time and lowest SpO(2) measurement are recorded. This test was performed on the first day of arriving at 11,060 ft, and after 9 days at the same location. The 37 male soldiers were all pre-acclimatized before arrival. The sleeping altitude remained constant at 11,060 ft, and the daytime altitudes increased up to a maximum of 15,775 ft. Test results improved significantly after a further 9 days of acclimatization (time, -11 s; SpO(2), +5%-points; p <= 0.001). This is remarkable because all soldiers were pre-acclimatized and showed only minor acute mountain sickness symptoms during the entire stay. This indicates that the acclimatization process is not finished after amelioration of altitude symptoms. The demonstrated improvement in physical performance could prove very important, particularly during military missions performed at high altitude.
C1 [Tannheimer, Markus] Armed Forces Hosp Ulm, Dept Visceral & Thorac Surg, D-89081 Ulm, Germany.
[Buzzelli, Mark D.] Womack Army Med Ctr, Dept Gen Surg, Ft Bragg, NC 28307 USA.
[Albertini, Nadine; Ulmer, Hans-V] Johannes Gutenberg Univ Mainz, Dept Sports Physiol, D-55099 Mainz, Germany.
[Lechner, Raimund] Kommando Spezialkrafte, D-76365 Calw, Germany.
[Engelhardt, Michael] Armed Forces Hosp Ulm, Dept Vasc Surg, D-89081 Ulm, Germany.
RP Tannheimer, M (reprint author), Armed Forces Hosp Ulm, Dept Visceral & Thorac Surg, Oberer Eselsberg 40, D-89081 Ulm, Germany.
NR 10
TC 1
Z9 1
U1 1
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAY
PY 2013
VL 178
IS 5
BP 507
EP 510
DI 10.7205/MILMED-D-12-00410
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA V39YX
UT WOS:000209447400007
PM 23756008
ER
PT J
AU Holland, SR
Apodaca, A
Mabry, RL
AF Holland, Seth R.
Apodaca, Amy
Mabry, Robert L.
TI MEDEVAC: Survival and Physiological Parameters Improved With Higher
Level of Flight Medic Training
SO MILITARY MEDICINE
LA English
DT Article
AB Objective: Determine if a higher level of Army flight medic (AFM) training was associated with improved physiological state on arrival to a combat support hospital (CSH). Methods: A retrospective study comparing casualties who were evacuated by two AFM units with only Emergency Medical Technicians-Basic (EMT-Bs) to an Army National Guard unit with Critical Care Flight Paramedics (CCFPs) in Afghanistan with an injury severity score >16 in different time periods looking at their 48-hour mortality, hematocrit (HCT), base deficit (BD), oxygen saturation (SpO(2)), and physiological parameters on arrival to the CSH. Results: The CCFP group had better HCT [36.5 (8.8)] than the EMT-B group [33.1 (11.4); p <= 0.001]. BD and SpO(2) were better in the CCFP group [-3.2 (4.7)]/[97.8 (4.8)] than the EMT-B group [-4.4 (5.5)]/[96.3 (10.9)] [p <= 0.014]. The CCFP group had a 72% lower estimated risk ratio of mortality with an associated improvement in 48-hour survivability of 4.9% versus 15.8% for the EMT-B-group. Conclusions: There is a statistically significant improvement in the HCT, BD, SpO(2), and 48-hour survivability at the CSH in the cohort transported by the CCFP group when compared to the cohort transported by the EMT-B group.
C1 [Holland, Seth R.; Apodaca, Amy; Mabry, Robert L.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Holland, SR (reprint author), US Army Inst Surg Res, 3698 Chambers Pass,Bldg 3611, Ft Sam Houston, TX 78234 USA.
NR 43
TC 3
Z9 3
U1 1
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAY
PY 2013
VL 178
IS 5
BP 529
EP 536
DI 10.7205/MILMED-D-12-00286
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA V39YX
UT WOS:000209447400011
PM 23756012
ER
PT J
AU Srinivas, U
Chen, Y
Monga, V
Nasrabadi, NM
Tran, TD
AF Srinivas, Umamahesh
Chen, Yi
Monga, Vishal
Nasrabadi, Nasser M.
Tran, Trac D.
TI Exploiting Sparsity in Hyperspectral Image Classification via Graphical
Models
SO IEEE GEOSCIENCE AND REMOTE SENSING LETTERS
LA English
DT Article
DE Classification; hyperspectral imagery; joint sparsity model;
probabilistic graphical models; sparse representation; spatial
correlation
ID REMOTE-SENSING IMAGES
AB A significant recent advance in hyperspectral image (HSI) classification relies on the observation that the spectral signature of a pixel can be represented by a sparse linear combination of training spectra from an overcomplete dictionary. A spatiospectral notion of sparsity is further captured by developing a joint sparsity model, wherein spectral signatures of pixels in a local spatial neighborhood (of the pixel of interest) are constrained to be represented by a common collection of training spectra, albeit with different weights. A challenging open problem is to effectively capture the class conditional correlations between these multiple sparse representations corresponding to different pixels in the spatial neighborhood. We propose a probabilistic graphical model framework to explicitly mine the conditional dependences between these distinct sparse features. Our graphical models are synthesized using simple tree structures which can be discriminatively learnt (even with limited training samples) for classification. Experiments on benchmark HSI data sets reveal significant improvements over existing approaches in classification rates as well as robustness to choice of training.
C1 [Srinivas, Umamahesh; Monga, Vishal] Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA.
[Chen, Yi; Tran, Trac D.] Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA.
[Nasrabadi, Nasser M.] USA, Res Lab, Adelphi, MD 20783 USA.
RP Srinivas, U (reprint author), Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA.
EM uxs113@psu.edu; ychen98@jhu.edu; vmonga@engr.psu.edu;
nnasraba@arl.army.mil; trac@jhu.edu
FU National Science Foundation [CCF-1117545, CCF-0728893]; Army Research
Office [58110-MA-II, 60219-MA]; Office of Naval Research [N102-183-0208]
FX This work was supported in part by the National Science Foundation under
Grants CCF-1117545 and CCF-0728893, by the Army Research Office under
Grants 58110-MA-II and 60219-MA, and by the Office of Naval Research
under Grant N102-183-0208.
NR 22
TC 34
Z9 36
U1 2
U2 61
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1545-598X
J9 IEEE GEOSCI REMOTE S
JI IEEE Geosci. Remote Sens. Lett.
PD MAY
PY 2013
VL 10
IS 3
BP 505
EP 509
DI 10.1109/LGRS.2012.2211858
PG 5
WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote
Sensing; Imaging Science & Photographic Technology
SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science
& Photographic Technology
GA 046YX
UT WOS:000311802900019
ER
PT J
AU Ballard, JR
Howington, SE
Wilhelms, SC
AF Ballard, Jerrell R., Jr.
Howington, Stacy E.
Wilhelms, Steven C.
TI Laboratory-Based Rainfall Effects on LWIR Soil Reflectance
SO IEEE GEOSCIENCE AND REMOTE SENSING LETTERS
LA English
DT Article
DE Disturbed soil; long-wave infrared (LWIR) soil reflectance; rainfall
ID INFRARED MEASUREMENTS; EMISSIVITY; FIELD; TEMPERATURE; PRISTINE; SPECTRA
AB The long-wave infrared reflectance of in situ disturbed and undisturbed soils will often have distinct spectral characteristics that are dependent on the soil's physical and spectral constitutive properties. This study examines how rainfall alters the measured directional-hemispherical thermal infrared (8-14 mu m) spectral reflectance of a disturbed soil with a specified sand/silt ratio using a calibrated rainfall simulator. For an accumulated rainfall of 8.0 cm, the mean disturbed soil thermal infrared spectral reflectance within 8.1-9.2-mu m waveband increases from an initial reflectance of 13% to a maximum reflectance of 31%. Sixty percent of this reflectance change occurred with only 1.0-cm accumulated rainfall. This study shows that, for this described disturbed sand/silt soil mixture, small accumulated rainfall amounts significantly alter the directional-hemispherical thermal infrared spectral reflectance.
C1 [Ballard, Jerrell R., Jr.] USA, Geotech & Struct Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Howington, Stacy E.] USA, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Wilhelms, Steven C.] Bowhead Sci & Technol Inc, Vicksburg, MS 39180 USA.
RP Ballard, JR (reprint author), USA, Geotech & Struct Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
EM jerry.ballard@us.army.mil; stacy.e.howington@usace.army.mil;
steven.c.wilhelms@erdc.dren.mil
FU U.S. Army Engineer Research and Development Center under the Military
Engineering Basic Research Program
FX This work was supported by the U.S. Army Engineer Research and
Development Center under the Military Engineering Basic Research
Program.
NR 15
TC 2
Z9 2
U1 0
U2 21
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1545-598X
J9 IEEE GEOSCI REMOTE S
JI IEEE Geosci. Remote Sens. Lett.
PD MAY
PY 2013
VL 10
IS 3
BP 627
EP 630
DI 10.1109/LGRS.2012.2216250
PG 4
WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote
Sensing; Imaging Science & Photographic Technology
SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science
& Photographic Technology
GA 046YX
UT WOS:000311802900044
ER
PT J
AU Lewis, JA
Gehman, EA
Baer, CE
Jackson, DA
AF Lewis, John A.
Gehman, Elizabeth A.
Baer, Christine E.
Jackson, David A.
TI Alterations in gene expression in Caenorhabditis elegans associated with
organophosphate pesticide intoxication and recovery
SO BMC GENOMICS
LA English
DT Article
DE Caenorhabditis elegans; Organophosphate pesticide intoxication; Gene
expression; Dichlorvos; Acetylcholinesterase inhibition; Mitochondrial
disruption; Dichlorvos-induced developmental delay
ID AXON REGENERATION REQUIRES; TRANSCRIPTION FACTOR; INNATE IMMUNITY;
C-ELEGANS; SIGNALING PATHWAY; OXIDATIVE STRESS; KINASE PATHWAY; MAP
KINASE; LIFE-SPAN; LONGEVITY
AB Background: The principal toxicity of acute organophosphate (OP) pesticide poisoning is the disruption of neurotransmission through inhibition of acetylcholinesterase (AChE). However, other mechanisms leading to persistent effects and neurodegeneration remain controversial and difficult to detect. Because Caenorhabditis elegans is relatively resistant to OP lethality-particularly through the inhibition of AChE-studies in this nematode provide an opportunity to observe alterations in global gene expression following OP exposure that cannot be readily observed in less resistant organisms.
Results: We exposed cultures of worms in axenic, defined medium to dichlorvos under three exposure protocols. In the first, worms were exposed continuously throughout the experiment. In the second and third, the worms were exposed for either 2 or 8 h, the dichlorvos was washed out of the culture, and the worms were allowed to recover. We then analyzed gene expression using whole genome microarrays from RNA obtained from worms sampled at multiple time points throughout the exposure. The worms showed a time-dependent increase in the expression of genes involved in stress responses. Early in the exposure, the predominant effect was on metabolic processes, while at later times, an immune-like response and cellular repair mechanisms dominated the expression pattern. Following removal of dichlorvos, the gene expression in the worms appeared to relatively rapidly return to steady-state levels.
Conclusion: The changes in gene expression observed in the worms following exposure to dichlorvos point towards two potential mechanisms of toxicity: inhibition of AChE and mitochondrial disruption.
C1 [Lewis, John A.; Jackson, David A.] USA, Ctr Environm Hlth Res, Ft Detrick, MD USA.
[Baer, Christine E.] Excet Inc, Ft Detrick, MD USA.
RP Lewis, JA (reprint author), USA, Ctr Environm Hlth Res, Ft Detrick, MD USA.
EM john.a.lewis1@us.army.mi
RI Jackson, David/E-9984-2014
FU Alan Rosencrance for quantitative analysis of dichlorvos stocks and
media; Army Independent Laboratory Innovative Research award; Military
Operational Medicine Research Program of the US Army Medical Research
and Materiel Command
FX The authors and the US Army Center for Environmental Health Research
wish to thank the following individuals for their support and
assistance: Debbie French for testing CeHR medium; Martin Nau and other
members of Dr. Maryanne Vahey's laboratory for microarray processing;
Dr. Maryanne Vahey, of the Division of Retrovirology, Walter Reed Army
Institute of Research for very generous research support; Alan
Rosencrance for quantitative analysis of dichlorvos stocks and media.
The research was supported in part by an Army Independent Laboratory
Innovative Research award to DAJ and JAL and by the Military Operational
Medicine Research Program of the US Army Medical Research and Materiel
Command. Opinions, interpretations, conclusions, and recommendations are
those of the authors and are not necessarily endorsed by the U.S. Army.
Citations of commercial organizations or trade names in this report do
not constitute an official Department of the Army endorsement or
approval of the products or services of these organizations.
NR 68
TC 7
Z9 7
U1 2
U2 34
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2164
J9 BMC GENOMICS
JI BMC Genomics
PD APR 30
PY 2013
VL 14
AR 291
DI 10.1186/1471-2164-14-291
PG 17
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA 150RB
UT WOS:000319407400001
PM 23631360
ER
PT J
AU Xie, JQ
Mita, S
Bryan, Z
Guo, W
Hussey, L
Moody, B
Schlesser, R
Kirste, R
Gerhold, M
Collazo, R
Sitar, Z
AF Xie, Jinqiao
Mita, Seiji
Bryan, Zachary
Guo, Wei
Hussey, Lindsay
Moody, Baxter
Schlesser, Raoul
Kirste, Ronny
Gerhold, Michael
Collazo, Ramon
Sitar, Zlatko
TI Lasing and longitudinal cavity modes in photo-pumped deep ultraviolet
AlGaN heterostructures
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID LIGHT-EMITTING-DIODES; QUANTUM-WELL LASER; ALN; GROWTH; GAN; NM
AB To unambiguously distinguish lasing from super luminescence, key elements of lasing such as longitudinal cavity modes with narrow line-width, polarized emission, and elliptically shaped far-field pattern, need to be demonstrated at the same time. Here, we show transverse electric polarized lasing at 280.8 nm and 263.9 nm for AlGaN based multi-quantum-wells and double heterojunction structures fabricated on single crystalline AlN substrates. An elliptically shaped far-field pattern was recorded when pumped above threshold. With cavities shorter than 200 mu m, well-defined, equally spaced longitudinal modes with line widths as narrow as 0.014 nm were observed. The low threshold pumping density of 84kW/cm(2) suggests that the electrically pumped sub-300 nm ultraviolet laser diodes are imminent. (C) 2013 AIP Publishing LLC.
C1 [Xie, Jinqiao; Mita, Seiji; Moody, Baxter; Schlesser, Raoul] HexaTech Inc, Morrisville, NC 27560 USA.
[Bryan, Zachary; Guo, Wei; Hussey, Lindsay; Kirste, Ronny; Collazo, Ramon; Sitar, Zlatko] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA.
[Gerhold, Michael] Army Res Off, Engn Sci Directorate, Res Triangle Pk, NC 27703 USA.
RP Xie, JQ (reprint author), HexaTech Inc, 991 Aviat Pkwy,Suite 800, Morrisville, NC 27560 USA.
EM axie@hexatechinc.com
NR 23
TC 43
Z9 43
U1 3
U2 43
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0003-6951
EI 1077-3118
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD APR 29
PY 2013
VL 102
IS 17
AR 171102
DI 10.1063/1.4803689
PG 4
WC Physics, Applied
SC Physics
GA 139AG
UT WOS:000318553000002
ER
PT J
AU Sliozberg, YR
Mrozek, RA
Schieber, JD
Kroger, M
Lenhart, JL
Andzelm, JW
AF Sliozberg, Yelena R.
Mrozek, Randy A.
Schieber, Jay D.
Kroeger, Martin
Lenhart, Joseph L.
Andzelm, Jan W.
TI Effect of polymer solvent on the mechanical properties of entangled
polymer gels: Coarse-grained molecular simulation
SO POLYMER
LA English
DT Article
DE Polymer; Modeling; Entanglements
ID DISSIPATIVE PARTICLE DYNAMICS; CONSTANT STRAIN; MELTS; NETWORKS;
RHEOLOGY; STRESS; EQUILIBRATION; PERFORMANCE; HYDROGELS; SYSTEMS
AB Polymer gels are composed of a chemically or physically cross-linked polymer that is highly swollen with solvent. Two important limitations for the practical application of polymer gels are low toughness and a limited ability to tailor the strain-rate dependent mechanical response. Both these limitations are due to the high loadings of small molecule solvents that are typically incorporated into the gel formulation. Here, we provide insight into the role of physical entanglements on the performance of polymer gels, when the solvent molecular weight is large enough to entangle with the polymer network. Our simulations demonstrate that the solvent entanglements dominate the time-dependent elastic modulus of polymer gels with high-molecular-weight solvent. We have found that entanglement contribution to the modulus is essentially equal for the entangled polymer melt and loosely cross-linked entangled polymer gel at high strain rate. At lower strain rate, the modulus of the polymer gels develops a long-lived plateau that originates from "semi-trapped" entanglements formed between network strands and polymer solvent. The simulations were validated with selected experiments of chemically cross-linked polydimethylsiloxane (PDMS) elastomers loaded with a non-reactive silicone oil solvent, where the solvent molecular weight was varied. The simulations and experimental results demonstrate that highly entangled solvent can be used to tune the rate dependent modulus of polymer gels. Published by Elsevier Ltd.
C1 [Sliozberg, Yelena R.; Mrozek, Randy A.; Lenhart, Joseph L.; Andzelm, Jan W.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Schieber, Jay D.] IIT, Dept Chem & Biol Engn, Chicago, IL 60616 USA.
[Schieber, Jay D.] IIT, Dept Phys, Chicago, IL 60616 USA.
[Schieber, Jay D.] IIT, Ctr Mol Study Condensed Soft Matter, Chicago, IL 60616 USA.
[Kroeger, Martin] ETH, Dept Mat, CH-8093 Zurich, Switzerland.
RP Andzelm, JW (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM jan.w.andzelm.civ@mail.mil
RI Schieber, Jay/F-9293-2012; Kroger, Martin/C-1946-2008
OI Schieber, Jay/0000-0002-9644-5236; Kroger, Martin/0000-0003-1402-6714
FU US Army Research Laboratory Enterprise for Multi-scale Research of
Materials; Army Research Office [W911NF-08-2-0058, W911NF-09-2-0071];
Postgraduate Research Participation Program at the US Army Research
Laboratory (ARL)
FX This work was partially funded by the US Army Research Laboratory
Enterprise for Multi-scale Research of Materials. This research was
supported in part by an appointment to the Postgraduate Research
Participation Program at the US Army Research Laboratory (ARL),
administered by the Oak Ridge Institute of Science and Education through
an interagency agreement between the US Department of Energy and ARL.
Support to JDS by Army Research Office Grants W911NF-08-2-0058 and
W911NF-09-2-0071 are gratefully acknowledged. We are grateful to Timothy
W. Sirk and Tanya L Chantawansri for productive discussion.
NR 55
TC 16
Z9 16
U1 5
U2 99
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0032-3861
J9 POLYMER
JI Polymer
PD APR 26
PY 2013
VL 54
IS 10
BP 2555
EP 2564
DI 10.1016/j.polymer.2013.03.017
PG 10
WC Polymer Science
SC Polymer Science
GA 133LD
UT WOS:000318139000011
ER
PT J
AU Taylor, DE
AF Taylor, DeCarlos E.
TI Intermolecular Forces and Molecular Dynamics Simulation of
1,3,5-Triamino-2,4,6-trinitrobenzene (TATB) Using Symmetry Adapted
Perturbation Theory
SO JOURNAL OF PHYSICAL CHEMISTRY A
LA English
DT Article
ID KOHN-SHAM ORBITALS; CRYSTAL-STRUCTURE; AB-INITIO; FIELD; DENSITY;
COMPRESSION; ENERGIES; MONOMERS; REAXFF; STATE
AB The dimer potential energy surface (PES) of 1,3,5-triamino-2,4,6-trinitrobenzene (TATB) has been explored using symmetry adapted perturbation theory based on a Kohn-Sham density functional theory description of the monomers [SAPT(DFT)]. An intermolecular potential energy function was parametrized using a grid of 880 ab initio SAPT(DFT) dimer interaction energies, and the function was used to identify stationary points on the SAPT(DFT) dimer PES. It is shown that there exists a variety of minima with a range of bonding configurations and ab initio analyses of the interaction energy components, along with radial cross sections of the PES near each minimum, are presented. Results of isothermal-isostress molecular dynamics simulations are reported, and the simulated structure, thermal expansion, sublimation enthalpy, and bulk modulus of the TATB crystal, based on the SAPT(DFT) interaction potential, are in good agreement with experiment.
C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Taylor, DE (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM decarlos.e.taylor.civ@mail.mil
NR 44
TC 10
Z9 12
U1 5
U2 39
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1089-5639
J9 J PHYS CHEM A
JI J. Phys. Chem. A
PD APR 25
PY 2013
VL 117
IS 16
BP 3507
EP 3520
DI 10.1021/jp4005289
PG 14
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA 134LJ
UT WOS:000318211400026
PM 23565605
ER
PT J
AU Baechle, DM
Demaree, JD
Hirvonen, JK
Wetzel, ED
AF Baechle, Daniel M.
Demaree, John D.
Hirvonen, James K.
Wetzel, Eric D.
TI Magnetron sputter deposition onto fluidized particle beds
SO SURFACE & COATINGS TECHNOLOGY
LA English
DT Article
DE Fluidized bed; Sputter deposition; Microspheres; Optical film; Surface
modification
ID CHEMICAL-VAPOR-DEPOSITION; FILMS; MICROSPHERES; COMPOSITES; CATALYST;
REACTOR; CVD
AB A system for sputter deposition of thin (10-1000 nm) metal and ceramic coatings onto vibro-fluidized beds of millions of microparticles has been demonstrated. Coatings are sputtered onto microspheres of various size distributions. Experiments show that the coating deposition rate onto particles decreases with decreasing particle size, for the case of a fixed total bed mass. Factors affecting particle coating thickness also include sputter power and fluidized bed container size. Coating surface morphology is evaluated using scanning electron microscopy. Lower sputter deposition power creates smoother, less porous coatings. Fluidizing parameters, such as vibration amplitude and frequency, are also shown to affect coating morphology. Dual-layer metal-ceramic coatings are also demonstrated using the sputter deposition technique. A dual-layer aluminum/tin-oxide coating is produced on glass microspheres, which are then shown to have distinct reflectance characteristics and colors. A model is developed to estimate coating thickness based on size, shape and number of particles. Published by Elsevier B.V.
C1 [Baechle, Daniel M.; Demaree, John D.; Hirvonen, James K.; Wetzel, Eric D.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Wetzel, ED (reprint author), USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM eric.d.wetzel2.civ@mail.mil
NR 30
TC 1
Z9 1
U1 2
U2 15
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0257-8972
J9 SURF COAT TECH
JI Surf. Coat. Technol.
PD APR 25
PY 2013
VL 221
BP 94
EP 103
DI 10.1016/j.surfcoat.2013.01.032
PG 10
WC Materials Science, Coatings & Films; Physics, Applied
SC Materials Science; Physics
GA 131MT
UT WOS:000317998500012
ER
PT J
AU Robinson, PD
Kassu, A
Sharma, A
Kukhtareva, T
Farley, CW
Smith, C
Ruffin, P
Brantley, C
Edwards, E
AF Robinson, Paul David
Kassu, Aschalew
Sharma, Anup
Kukhtareva, Tatiana
Farley, Carlton William, III
Smith, Cydale
Ruffin, Paul
Brantley, Christina
Edwards, Eugene
TI Surface-enhanced Raman spectroscopy scattering from gold-coated ceramic
nanopore substrates: effect of nanopore size
SO JOURNAL OF NANOPHOTONICS
LA English
DT Article
DE surface-enhanced Raman spectroscopy; interparticle distance; anodic
aluminum oxide; nanoporous membrane
ID PLASMON RESONANCE; LIGHT; EXCITATION; DEPENDENCE; JUNCTIONS; MOLECULES;
SILVER
AB The dependence of magnitude of the electric near-field on the separation between metal nanoparticles for surface-enhanced Raman spectroscopy (SERS) substrates was experimentally verified. Diameters of gold-coated nanopores in a ceramic alumina substrate were varied to study the charge buildup near interparticle junctions and its effect on the enhancement factor due to SERS. The substrates were characterized by sensing a Rhodamine dye and calculating the associated Raman enhancement factors. Decreasing Au interparticle distance increases the electric near-field and shifts the plasmon resonance peak accordingly. (C) 2013 Society of Photo-Optical Instrumentation Engineers (SPIE) [DOI: 10.1117/1.JNP.7.073592]
C1 [Robinson, Paul David; Sharma, Anup; Kukhtareva, Tatiana; Farley, Carlton William, III] Alabama A&M Univ, Dept Phys Chem & Math, Normal, AL 35762 USA.
[Kassu, Aschalew] Alabama A&M Univ, Dept Engn Construct Management & Ind Technol, Normal, AL 35762 USA.
[Smith, Cydale] Alabama A&M Univ, Ctr Irradiat Mat, Normal, AL 35762 USA.
[Ruffin, Paul; Brantley, Christina; Edwards, Eugene] USA, Res Dev & Engn Command, Huntsville, AL 35898 USA.
RP Robinson, PD (reprint author), Alabama A&M Univ, Dept Phys Chem & Math, 4900 Meridian St, Normal, AL 35762 USA.
EM robinsonpaul82@yahoo.com
FU U.S. Army RDECOM; Huntsville; Alabama [35898]; NSF-RISE; Alabama
NSF-EPSCoR; NASA-EPSCoR [NNX12A109A]; NASA [NNX10AJ]
FX This study was funded by U.S. Army RDECOM, Huntsville, Alabama 35898,
NSF-RISE, Alabama NSF-EPSCoR, NASA-EPSCoR Grant NNX12A109A, and NASA
Training Grant NNX10AJ. P. Robinson conducted SERS experiments and wrote
the manuscript. A. Kassu helped edit the manuscript and conduct
multiconcentration SERS measurements. A. Sharma helped write and edit
the manuscript and originated the idea to use AAO nanopores. T.
Kukhtareva helped with SEM, C. W. Farley conducted absorption
measurements, and C. Smith helped deposit gold films. Dr. Ruffin, C.
Brantley, and E. Edwards have been an integral part of the team in SERS
experiments, editing the manuscript, involvement in various stages of
planning and implementation, and they provided valuable inputs for the
importance of this work for the Army. This work is part of P. Robinson's
master's thesis, and A. Sharma and P. Ruffin served on his masters
committee.
NR 27
TC 3
Z9 3
U1 3
U2 59
PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA
SN 1934-2608
J9 J NANOPHOTONICS
JI J. Nanophotonics
PD APR 25
PY 2013
VL 7
AR 073592
DI 10.1117/1.JNP.7.073592
PG 9
WC Nanoscience & Nanotechnology; Optics
SC Science & Technology - Other Topics; Optics
GA 133NE
UT WOS:000318144300001
ER
PT J
AU Lawhern, V
Hairston, WD
Robbins, K
AF Lawhern, Vernon
Hairston, W. David
Robbins, Kay
TI DETECT: A MATLAB Toolbox for Event Detection and Identification in Time
Series, with Applications to Artifact Detection in EEG Signals
SO PLOS ONE
LA English
DT Article
ID INDEPENDENT COMPONENT ANALYSIS; CLASSIFICATION; SYSTEM
AB Recent advances in sensor and recording technology have allowed scientists to acquire very large time-series datasets. Researchers often analyze these datasets in the context of events, which are intervals of time where the properties of the signal change relative to a baseline signal. We have developed DETECT, a MATLAB toolbox for detecting event time intervals in long, multi-channel time series. Our primary goal is to produce a toolbox that is simple for researchers to use, allowing them to quickly train a model on multiple classes of events, assess the accuracy of the model, and determine how closely the results agree with their own manual identification of events without requiring extensive programming knowledge or machine learning experience. As an illustration, we discuss application of the DETECT toolbox for detecting signal artifacts found in continuous multi-channel EEG recordings and show the functionality of the tools found in the toolbox. We also discuss the application of DETECT for identifying irregular heartbeat waveforms found in electrocardiogram ( ECG) data as an additional illustration.
C1 [Lawhern, Vernon; Robbins, Kay] Univ Texas San Antonio, Dept Comp Sci, San Antonio, TX 78249 USA.
[Hairston, W. David] USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA.
RP Lawhern, V (reprint author), Univ Texas San Antonio, Dept Comp Sci, San Antonio, TX 78249 USA.
EM Vernon.Lawhern@utsa.edu
OI Hairston, W. David/0000-0003-4432-8430
FU Army Research Laboratory; [W911NF-10-2-0022]
FX This research was sponsored by the Army Research Laboratory and was
accomplished under Cooperative Agreement Number W911NF-10-2-0022. The
views and conclusions contained in this document are those of the
authors and should not be interpreted as representing the official
policies, either expressed or implied, of the Army Research Laboratory
or the U.S. Government. The U.S. Government is authorized to reproduce
and distribute reprints for Government purposes notwithstanding any
copyright notation herein. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
NR 29
TC 9
Z9 9
U1 2
U2 16
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 24
PY 2013
VL 8
IS 4
AR e62944
DI 10.1371/journal.pone.0062944
PG 13
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 136DE
UT WOS:000318340400133
PM 23638169
ER
PT J
AU Propper, RE
McGraw, SE
Brunye, TT
Weiss, M
AF Propper, Ruth E.
McGraw, Sean E.
Brunye, Tad T.
Weiss, Michael
TI Getting a Grip on Memory: Unilateral Hand Clenching Alters Episodic
Recall
SO PLOS ONE
LA English
DT Article
ID HEMISPHERIC ACTIVATION; AFFECTIVE STYLE; HANDEDNESS; EMOTION;
CONTRACTION; ASYMMETRIES; EXPERIENCE; MUSCLES
AB Unilateral hand clenching increases neuronal activity in the frontal lobe of the contralateral hemisphere. Such hand clenching is also associated with increased experiencing of a given hemisphere's "mode of processing.'' Together, these findings suggest that unilateral hand clenching can be used to test hypotheses concerning the specializations of the cerebral hemispheres during memory encoding and retrieval. We investigated this possibility by testing effects of unilateral hand clenching on episodic memory. The hemispheric Encoding/Retrieval Asymmetry (HERA) model proposes left prefrontal regions are associated with encoding, and right prefrontal regions with retrieval, of episodic memories. It was hypothesized that right hand clenching (left hemisphere activation) pre-encoding, and left hand clenching (right hemisphere activation) pre-recall, would result in superior memory. Results supported the HERA model. Also supported was that simple unilateral hand clenching can be used as a means by which the functional specializations of the cerebral hemispheres can be investigated in intact humans.
C1 [Propper, Ruth E.; McGraw, Sean E.; Weiss, Michael] Montclair State Univ, Dept Psychol, Montclair, NJ 07043 USA.
[Brunye, Tad T.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA.
[Brunye, Tad T.] USA, Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA.
RP Propper, RE (reprint author), Montclair State Univ, Dept Psychol, Montclair, NJ 07043 USA.
EM propperr@mail.montclair.edu
FU U.S. Army [W911QY-12-C-0046]
FX Parts of this work were supported by U.S. Army contract
#W911QY-12-C-0046 to author R.E.P. The opinions expressed herein are
those of the authors and not necessarily of the US Army. The funders had
no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript. No additional external
funding was received for this study.
NR 18
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U1 1
U2 42
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 24
PY 2013
VL 8
IS 4
AR e62474
DI 10.1371/journal.pone.0062474
PG 4
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 136DE
UT WOS:000318340400111
PM 23638094
ER
PT J
AU Rosch, TW
Brennan, JK
Izvekov, S
Andzelm, JW
AF Rosch, Thomas W.
Brennan, John K.
Izvekov, Sergei
Andzelm, Jan W.
TI Exploring the ability of a multiscale coarse-grained potential to
describe the stress-strain response of glassy polystyrene
SO PHYSICAL REVIEW E
LA English
DT Article
ID DISSIPATIVE PARTICLE DYNAMICS; MOLECULAR-DYNAMICS; POLYMER GLASSES;
STEADY SHEAR; FORCE-FIELD; SIMULATIONS; SYSTEMS; DEFORMATION;
TEMPERATURE; MECHANICS
AB A new particle-based bottom-up method to develop coarse-grained models of polymers is presented and applied to polystyrene. The multiscale coarse-graining (MS-CG) technique of Izvekov et al. [J. Chem. Phys. 120, 10896 (2004)] is applied to a polymer system to calculate nonbonded interactions. The inverse Boltzmann inversion method was used to parametrize the bonded and bond-angle bending interactions. Molecular dynamics simulations were performed, and the CG model exhibited a significantly lower modulus compared to the atomistic model at low temperature and high strain rate. In an attempt to improve the CG model performance, several other parametrization schemes were used to build other models from this base model. The first of these models included standard frictional forces through use of the constant-temperature dissipative particle dynamics method that improved the modulus, yet was not transferrable to higher temperatures and lower strain rates. Other models were built by increasing the attraction between CG beads through direct manipulation of the nonbonded potential, where an improvement of the stress response was found. For these models, two parametrization protocols that shifted the force to more attractive values were explored. The first protocol involved a uniform shift, while the other protocol shifted the force in a more localized region. The uniformly shifted potential greatly affected the structure of the equilibrium model as compared to the locally shifted potential, yet was more transferrable to different temperatures and strain rates. Further improvements in the coarse-graining protocol to generate models that more satisfactorily capture mechanical properties are suggested. DOI:10.1103/PhysRevE.87.042606
C1 [Rosch, Thomas W.; Brennan, John K.; Izvekov, Sergei; Andzelm, Jan W.] Weap & Mat Res Directorate, US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Andzelm, JW (reprint author), Weap & Mat Res Directorate, US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM jan.w.andzelm.civ@mail.mil
FU US Army Research Laboratory Enterprise for Multi-Scale Research of
Materials; US Army Research Laboratory
FX This work was funded by the US Army Research Laboratory Enterprise for
Multi-Scale Research of Materials. This research was supported in part
by the Post-Graduate Research Participation Program at the US Army
Research Laboratory administered by the Oak Ridge Institute for Science
and Education. The authors would also like to acknowledge the help of
Yelena Sliozberg (ARL) in generating the large CG systems and Craig Knox
(US Army Edgewood Chemical Biological Center) for very useful LAMMPS
scripts.
NR 64
TC 10
Z9 10
U1 9
U2 62
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 1539-3755
J9 PHYS REV E
JI Phys. Rev. E
PD APR 24
PY 2013
VL 87
IS 4
AR 042606
DI 10.1103/PhysRevE.87.042606
PG 14
WC Physics, Fluids & Plasmas; Physics, Mathematical
SC Physics
GA 131BX
UT WOS:000317967300001
PM 23679442
ER
PT J
AU de Ceglia, D
Campione, S
Vincenti, MA
Capolino, F
Scalora, M
AF de Ceglia, Domenico
Campione, Salvatore
Vincenti, Maria Antonietta
Capolino, Filippo
Scalora, Michael
TI Low-damping epsilon-near-zero slabs: Nonlinear and nonlocal optical
properties
SO PHYSICAL REVIEW B
LA English
DT Article
ID PSEUDO-BREWSTER ANGLE; ELECTROMAGNETIC ENHANCEMENT; PLASMONIC
NANOSPHERES; METAMATERIAL SLAB; PERIODIC ARRAYS; NANOWIRE DIMERS;
COMPLEX-MODES; LEAKY MODES; PERMITTIVITY; NANOPARTICLES
AB We investigate second-harmonic generation, low-threshold multistability, all-optical switching, and inherently nonlocal effects due to the free-electron gas pressure in an epsilon-near-zero (ENZ) metamaterial slab made of cylindrical, plasmonic nanoshells illuminated by TM-polarized light. Damping compensation in the ENZ frequency region, achieved by using gain medium inside the nanoshells' dielectric cores, enhances the nonlinear properties. Reflection is inhibited, and the electric field component normal to the slab interface is enhanced near the effective pseudo-Brewster angle, where the effective e approximate to 0 condition triggers a nonresonant, impedance-matching phenomenon. We show that the slab displays a strong effective, spatial nonlocality associated with leaky modes that are mediated by the compensation of damping. The presence of these leaky modes then induces further spectral and angular conditions, where the local fields are enhanced, thus opening new windows of opportunity for the enhancement of nonlinear optical processes. DOI: 10.1103/PhysRevB.87.155140
C1 [de Ceglia, Domenico; Vincenti, Maria Antonietta] Natl Res Council AMRDEC, Charles M Bowden Res Lab, Redstone Arsenal, AL 35898 USA.
[Campione, Salvatore; Capolino, Filippo] Univ Calif Irvine, Dept Elect Engn & Comp Sci, Irvine, CA 92697 USA.
[Scalora, Michael] USA, RDECOM, AMRDEC, Charles M Bowden Res Lab, Redstone Arsenal, AL 35898 USA.
RP de Ceglia, D (reprint author), Natl Res Council AMRDEC, Charles M Bowden Res Lab, Redstone Arsenal, AL 35898 USA.
EM domenico.deceglia@us.army.mil
RI Campione, Salvatore/A-2349-2015
OI Campione, Salvatore/0000-0003-4655-5485
FU National Research Council
FX This research was performed while the authors M. A. Vincenti and D. de
Ceglia held a National Research Council Research Associateship award at
the US Army Aviation and Missile Research Development and Engineering
Center.
NR 76
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U1 3
U2 47
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 1098-0121
EI 1550-235X
J9 PHYS REV B
JI Phys. Rev. B
PD APR 22
PY 2013
VL 87
IS 15
DI 10.1103/PhysRevB.87.155140
PG 12
WC Physics, Condensed Matter
SC Physics
GA 129FG
UT WOS:000317823800004
ER
PT J
AU Lemasson, BH
Anderson, JJ
Goodwin, RA
AF Lemasson, Bertrand H.
Anderson, James J.
Goodwin, R. Andrew
TI Motion-guided attention promotes adaptive communications during social
navigation (vol 280, 20122003, 2013)
SO PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
LA English
DT Correction
C1 [Goodwin, R. Andrew] USA, Environm Lab, Engineer Res & Dev Ctr, Portland, OR 97208 USA.
NR 1
TC 0
Z9 0
U1 0
U2 10
PU ROYAL SOC
PI LONDON
PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND
SN 0962-8452
J9 P ROY SOC B-BIOL SCI
JI Proc. R. Soc. B-Biol. Sci.
PD APR 22
PY 2013
VL 280
IS 1757
AR 20130304
DI 10.1098/rspb.2013.0304
PG 1
WC Biology; Ecology; Evolutionary Biology
SC Life Sciences & Biomedicine - Other Topics; Environmental Sciences &
Ecology; Evolutionary Biology
GA 103XV
UT WOS:000315953700021
ER
PT J
AU Vakula, NI
Kuramshina, GM
Gorb, LG
Hill, F
Leszczynski, J
AF Vakula, Nikita I.
Kuramshina, Gulnara M.
Gorb, Leonid G.
Hill, Frances
Leszczynski, Jerzy
TI Adsorption and diffusion of a silver atom and its cation on alpha-SiO2
(0 0 1): Comparison of a pure surface with a surface containing an Al
defect
SO CHEMICAL PHYSICS LETTERS
LA English
DT Article
ID AB-INITIO; ELECTRIC-FIELD; QUARTZ; CLUSTERS; AG; NANOPARTICLES; FILMS;
SIO2
AB By employing DFT approaches we studied the adsorption of a single Ag atom and its cation on different sites of a pure alpha-quartz (001) surface and on an alpha-quartz (001) surface containing an Al defect. The energetically different adsorption sites of Ag and Ag+ were revealed and the profiles of diffusion were calculated. Diffusion of an Ag atom through the pure alpha-quartz surface is predicted to have a much lower barrier than an Ag cation. However in case of diffusion through the alpha-quartz surface with an Al defect the barriers are almost the same for both cation and neutral Ag. (C) 2013 Elsevier B. V. All rights reserved.
C1 [Vakula, Nikita I.; Kuramshina, Gulnara M.] Moscow MV Lomonosov State Univ, Dept Phys Chem, Fac Chem, Moscow 119991, Russia.
[Gorb, Leonid G.] Badger Tech Serv, Vicksburg, MS USA.
[Hill, Frances] USA, Erdc, Vicksburg, MS USA.
[Leszczynski, Jerzy] Jackson State Univ, ICNANOTOX, Dept Chem, Jackson, MS 39217 USA.
RP Vakula, NI (reprint author), Moscow MV Lomonosov State Univ, Dept Phys Chem, Fac Chem, Moscow 119991, Russia.
EM vakula.chem@gmail.com
RI Kuramshina, Gulnara/G-8974-2011
OI Kuramshina, Gulnara/0000-0002-4044-471X
FU RFBR [11-03-00040a]; National Science Foundation [NSF/CREST HRD-0833178,
NSF DMR-1205194]; Mississippi Center for Supercomputing Research (MCSR)
FX This work was partly supported by the RFBR grant No 11-03-00040a and by
the National Science Foundation grant (NSF/CREST HRD-0833178 and NSF
DMR-1205194).; We are grateful to the Research Computing Center of
Lomonosov Moscow State University for the computational facilities and
the use of the SKIF MSU 'Chebyshev' Supercomputer and to the Mississippi
Center for Supercomputing Research (MCSR) for generous computational
grant.
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U1 5
U2 32
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0009-2614
J9 CHEM PHYS LETT
JI Chem. Phys. Lett.
PD APR 19
PY 2013
VL 567
BP 27
EP 33
DI 10.1016/j.cplett.2013.02.067
PG 7
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA 122WQ
UT WOS:000317349600006
ER
PT J
AU Andres, D
Keyser, BM
Petrali, J
Benton, B
Hubbard, KS
McNutt, PM
Ray, R
AF Andres, Devon
Keyser, Brian M.
Petrali, John
Benton, Betty
Hubbard, Kyle S.
McNutt, Patrick M.
Ray, Radharaman
TI Morphological and functional differentiation in BE (2)-M17 human
neuroblastoma cells by treatment with Trans-retinoic acid
SO BMC NEUROSCIENCE
LA English
DT Article
DE Neurons; M17; Neurotoxicity; Cell maturation; Differentiation; Retinoic
acid; Neuroexocytosis; Voltage-gated calcium channels
ID IN-VITRO; HIPPOCAMPAL-NEURONS; PULMONARY TOXICITY; CALCIUM-CHANNELS;
NEUROTOXICITY; MODELS; LINES; MIXTURES; EXPOSURE; CULTURE
AB Background: Immortalized neuronal cell lines can be induced to differentiate into more mature neurons by adding specific compounds or growth factors to the culture medium. This property makes neuronal cell lines attractive as in vitro cell models to study neuronal functions and neurotoxicity. The clonal human neuroblastoma BE(2)-M17 cell line is known to differentiate into a more prominent neuronal cell type by treatment with trans-retinoic acid. However, there is a lack of information on the morphological and functional aspects of these differentiated cells.
Results: We studied the effects of trans-retinoic acid treatment on (a) some differentiation marker proteins, (b) types of voltage-gated calcium (Ca2+) channels and (c) Ca2+-dependent neurotransmitter ([H-3] glycine) release in cultured BE(2)-M17 cells. Cells treated with 10 mu M trans-retinoic acid (RA) for 72 hrs exhibited marked changes in morphology to include neurite extensions; presence of P/Q, N and T-type voltage-gated Ca2+ channels; and expression of neuron specific enolase (NSE), synaptosomal-associated protein 25 (SNAP-25), nicotinic acetylcholine receptor alpha 7 (nAChR-alpha 7) and other neuronal markers. Moreover, retinoic acid treated cells had a significant increase in evoked Ca2+-dependent neurotransmitter release capacity. In toxicity studies of the toxic gas, phosgene (CG), that differentiation of M17 cells with RA was required to see the changes in intracellular free Ca2+ concentrations following exposure to CG.
Conclusion: Taken together, retinoic acid treated cells had improved morphological features as well as neuronal characteristics and functions; thus, these retinoic acid differentiated BE(2)-M17 cells may serve as a better neuronal model to study neurobiology and/or neurotoxicity.
C1 [Andres, Devon; Keyser, Brian M.; Petrali, John; Benton, Betty; Hubbard, Kyle S.; McNutt, Patrick M.; Ray, Radharaman] USA, Div Res, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
RP Ray, R (reprint author), USA, Div Res, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM radharaman.ray@us.army.mil
OI Andres, Devon/0000-0002-6823-4132; McNutt, Patrick/0000-0002-5703-4565
FU Defense Threat Reduction Agency - Joint Science and Technology Office,
Medical ST Division [Y1-A1-6179-04]; NIH/NIAID [Y1-A1-6179-04]; USAMRICD
[A120-B. P2009-03]; U.S. Army Medical Research Institute of Chemical
Defense
FX This research was supported by the Defense Threat Reduction Agency -
Joint Science and Technology Office, Medical S&T Division, an
interagency agreement between NIH/NIAID (Y1-A1-6179-04) and the USAMRICD
(A120-B. P2009-03) and in part by an appointment to the Postgraduate
Research Participation Program at the U.S. Army Medical Research
Institute of Chemical Defense administered by the Oak Ridge Institute
for Science and Education through an interagency agreement between the
U.S. Department of Energy and U.S. Army Medical Research and Materiel
Command (USAMRMC). We acknowledge Dr. Heidi Hoard-Fruchey for giving us
the antibodies for our studies on the cholinergic properties and Dr.
Dorian Olivera for helping us with phosgene exposure of cells. We also
acknowledge Drs. Shane Kasten and Brian Molles for their careful reviews
of the manuscript and comments.
NR 40
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U1 1
U2 7
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2202
J9 BMC NEUROSCI
JI BMC Neurosci.
PD APR 18
PY 2013
VL 14
AR 49
DI 10.1186/1471-2202-14-49
PG 12
WC Neurosciences
SC Neurosciences & Neurology
GA 139WS
UT WOS:000318616300002
PM 23597229
ER
PT J
AU Borodin, O
Zhuang, GRV
Ross, PN
Xu, K
AF Borodin, Oleg
Zhuang, Guorong V.
Ross, Philip N.
Xu, Kang
TI Molecular Dynamics Simulations and Experimental Study of Lithium Ion
Transport in Dilithium Ethylene Dicarbonate
SO JOURNAL OF PHYSICAL CHEMISTRY C
LA English
DT Article
ID SOLID-ELECTROLYTE INTERPHASE; SOLVATION SHEATH STRUCTURE; AB-INITIO
CALCULATIONS; DOT-O INTERACTIONS; LI-ION; NONAQUEOUS ELECTROLYTES;
GRAPHITE/ELECTROLYTE INTERFACE; BATTERY ELECTROLYTES; PROPYLENE
CARBONATE; ALKYL DICARBONATES
AB Understanding the properties of the solid electrolyte interphase (SET) of lithium batteries is important for minimizing interfacial resistance and improving battery safety and cycling. Ion transport has been investigated in the dilithium ethylene dicarbonate (Li2EDC) component of the SEI by impedance spectroscopy and molecular dynamics (MD) simulations employing a revised many-body polarizable APPLE&P force field. The developed force field accurately described the binding energies in LiCH3CO3, its dimer, and Li2EDC calculated at the G4MP2 and MP2 levels. M05-2X and LC-omega PBE functionals predicted too high binding energy in lithium alkyl carbonates compared to the G4MP2 results, while the MP2 and M06-L predictions agreed well with the G4MP2 data. The conductivity of Li2EDC at room temperature was found to be 10(-9) S/cm from impedance measurements and extrapolation of MD simulation results. A near Arrhenius temperature dependence of Li2EDC's conductivity was found in the MD simulations with an activation energy ranging from 64 to 84 kJ/mol. At room temperature, the lithium transport was subdiffusive on time scales shorter than similar to 10(-2) s in MD simulations corresponding to the onset of the plateau of resistivity vs frequency occurring at frequencies lower than 10(2) Hz. The influence of Li2EDC ordering on the ion transport was investigated by contrasting supercooled amorphous melts and ordered material. At 393 K Li+ transport was heterogeneous, showing chainlike and looplike Li+ correlated displacements. The non-Gaussianity of Li+ transport was examined. The influence of polarization on the structure of the lithium coordination shell and ion transport has been investigated in the molten phase of Li2EDC and contrasted with the previous results obtained for room-temperature ionic liquids (RTILs). Nonpolarizable Li2EDC exhibited orders of magnitude slower dynamics below 600 K and a higher activation energy for the Li+ diffusion coefficient. Initial simulations of Li2EDC dissolved in an EC:DMC(3:7)/LiPF6 liquid electrolyte were performed at 450 K and showed a strong aggregation of Li2EDC consistent with its phase separation from the electrolyte. The plasticizing effects of carbonate electrolyte on Li2EDC dynamics were examined.
C1 [Borodin, Oleg; Xu, Kang] USA, Res Lab, Electrochem Branch, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
[Zhuang, Guorong V.; Ross, Philip N.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA.
RP Borodin, O (reprint author), USA, Res Lab, Electrochem Branch, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM oleg.a.borodin.civ@mail.mil
RI Borodin, Oleg/B-6855-2012
OI Borodin, Oleg/0000-0002-9428-5291
FU U.S. Department of Energy [DE-IA01-11EE003413]; U.S. Army Research
Laboratory (ARL) [DE-IA01-11EE003413]
FX This work was supported via an Interagency Agreement between the U.S.
Department of Energy and the U.S. Army Research Laboratory (ARL) under
DE-IA01-11EE003413 for the Office of Vehicle Technologies Programs
within Batteries for Advanced Transportation Technologies (BATT) and ABR
Program. Computational resources from DoD's High Performance Computing
Modernization Program's (HPCMP) program are acknowledged. Insightful
discussions with T. Richard Jow (ARL) are highly appreciated.
NR 60
TC 30
Z9 30
U1 5
U2 167
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1932-7447
J9 J PHYS CHEM C
JI J. Phys. Chem. C
PD APR 18
PY 2013
VL 117
IS 15
BP 7433
EP 7444
DI 10.1021/jp4000494
PG 12
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA 130WH
UT WOS:000317950300004
ER
PT J
AU Onmus-Leone, F
Hang, J
Clifford, RJ
Yang, Y
Riley, MC
Kuschner, RA
Waterman, PE
Lesho, EP
AF Onmus-Leone, Fatma
Hang, Jun
Clifford, Robert J.
Yang, Yu
Riley, Matthew C.
Kuschner, Robert A.
Waterman, Paige E.
Lesho, Emil P.
TI Enhanced De Novo Assembly of High Throughput Pyrosequencing Data Using
Whole Genome Mapping
SO PLOS ONE
LA English
DT Article
ID RESISTANT STAPHYLOCOCCUS-AUREUS; PROVIDENCIA-STUARTII; CLINICAL ISOLATE;
SEQUENCE; STRAIN; DIVERSITY; OUTBREAK; AFGHANISTAN; VALIDATION;
BLA(NDM-1)
AB Despite major advances in next-generation sequencing, assembly of sequencing data, especially data from novel microorganisms or re-emerging pathogens, remains constrained by the lack of suitable reference sequences. De novo assembly is the best approach to achieve an accurate finished sequence, but multiple sequencing platforms or paired-end libraries are often required to achieve full genome coverage. In this study, we demonstrated a method to assemble complete bacterial genome sequences by integrating shotgun Roche 454 pyrosequencing with optical whole genome mapping (WGM). The whole genome restriction map (WGRM) was used as the reference to scaffold de novo assembled sequence contigs through a stepwise process. Large de novo contigs were placed in the correct order and orientation through alignment to the WGRM. De novo contigs that were not aligned to WGRM were merged into scaffolds using contig branching structure information. These extended scaffolds were then aligned to the WGRM to identify the overlaps to be eliminated and the gaps and mismatches to be resolved with unused contigs. The process was repeated until a sequence with full coverage and alignment with the whole genome map was achieved. Using this method we were able to achieved 100% WGRM coverage without a paired-end library. We assembled complete sequences for three distinct genetic components of a clinical isolate of Providencia stuartii: a bacterial chromosome, a novel bla(NDM-1) plasmid, and a novel bacteriophage, without separately purifying them to homogeneity.
C1 [Onmus-Leone, Fatma; Clifford, Robert J.; Riley, Matthew C.; Waterman, Paige E.; Lesho, Emil P.] Walter Reed Army Inst Res, Multidrug Resistant Organism Surveillance Network, Silver Spring, MD USA.
[Hang, Jun; Yang, Yu; Kuschner, Robert A.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA.
RP Onmus-Leone, F (reprint author), Walter Reed Army Inst Res, Multidrug Resistant Organism Surveillance Network, Silver Spring, MD USA.
EM Fatma.Onmus-Leone.ctr@us.army.mil; Jun.Hang.ctr@us.army.mil
RI Valle, Ruben/A-7512-2013
FU United States Army Medical Command [09-050, 11-035]; Global Emerging
Infections Surveillance and Response System, a Division of the Armed
Forces Health Surveillance Center [C0709_12_WR, I0361_12_WR]
FX This study was supported by the United States Army Medical Command
Policies 09-050 and 11-035, and was partially funded by grants
C0709_12_WR and I0361_12_WR from the Global Emerging Infections
Surveillance and Response System, a Division of the Armed Forces Health
Surveillance Center. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
NR 47
TC 13
Z9 13
U1 0
U2 20
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 17
PY 2013
VL 8
IS 4
AR e61762
DI 10.1371/journal.pone.0061762
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 130IK
UT WOS:000317907200083
PM 23613926
ER
PT J
AU White, MT
Bejon, P
Olotu, A
Griffin, JT
Riley, EM
Kester, KE
Ockenhouse, CF
Ghani, AC
AF White, Michael T.
Bejon, Philip
Olotu, Ally
Griffin, Jamie T.
Riley, Eleanor M.
Kester, Kent E.
Ockenhouse, Christian F.
Ghani, Azra C.
TI The Relationship between RTS,S Vaccine-Induced Antibodies, CD4(+) T Cell
Responses and Protection against Plasmodium falciparum Infection
SO PLOS ONE
LA English
DT Article
ID MALARIA-NAIVE ADULTS; PHASE 2A TRIAL; POLYMERASE-CHAIN-REACTION;
INSTITUTE-OF-RESEARCH; CIRCUMSPOROZOITE PROTEIN; ANOPHELINE MOSQUITOS;
DOUBLE-BLIND; EFFICACY; SPOROZOITES; CHILDREN
AB Vaccination with the pre-erythrocytic malaria vaccine RTS,S induces high levels of antibodies and CD4(+) T cells specific for the circumsporozoite protein (CSP). Using a biologically-motivated mathematical model of sporozoite infection fitted to data from malaria-naive adults vaccinated with RTS, S and subjected to experimental P. falciparum challenge, we characterised the relationship between antibodies, CD4(+) T cell responses and protection from infection. Both anti-CSP antibody titres and CSP-specific CD4(+) T cells were identified as immunological surrogates of protection, with RTS,S induced anti-CSP antibodies estimated to prevent 32% (95% confidence interval (CI) 24%-41%) of infections. The addition of RTS,S induced CSP-specific CD4(+) T cells was estimated to increase vaccine efficacy against infection to 40% (95% CI, 34%-48%). This protective efficacy is estimated to result from a 96.1% (95% CI, 93.4%-97.8%) reduction in the liver-to-blood parasite inoculum, indicating that in volunteers who developed P. falciparum infection, a small number of parasites (often the progeny of a single surviving sporozoite) are responsible for breakthrough blood-stage infections.
C1 [White, Michael T.; Griffin, Jamie T.; Ghani, Azra C.] Univ London Imperial Coll Sci Technol & Med, Dept Infect Dis Epidemiol, MRC Ctr Outbreak Anal & Modelling, London, England.
[Bejon, Philip; Olotu, Ally] Kenya Govt Med Res Ctr, Kilifi, Kenya.
[Bejon, Philip] Univ Oxford, Ctr Clin Vaccinol & Trop Med, Oxford, England.
[Riley, Eleanor M.] Univ London London Sch Hyg & Trop Med, Fac Infect & Trop Dis, Dept Immunol & Infect, London WC1E 7HT, England.
[Kester, Kent E.; Ockenhouse, Christian F.] Walter Reed Army Inst Res, Silver Spring, MD USA.
RP White, MT (reprint author), Univ London Imperial Coll Sci Technol & Med, Dept Infect Dis Epidemiol, MRC Ctr Outbreak Anal & Modelling, London, England.
EM m.white08@imperial.ac.uk
RI Ghani, Azra/B-8560-2009; Riley, Eleanor/C-8960-2013
OI Riley, Eleanor/0000-0003-3447-3570
FU MRC Centre; MRC [G1002624]; Wellcome Trust; MVI/PATH; EviMalaR network;
Bill and Melinda Gates Foundation Vaccine Modelling Initiative
FX MTW was supported by an MRC Centre studentship. PB is funded by an MRC
Fellowship G1002624). AO is funded by a Wellcome Trust Strategic Award.
JTG is funded by an MRC Fellowship. EMR acknowledges funding from
MVI/PATH, the MRC and the EviMalaR network (EU FP7). ACG acknowledges
support from the Bill and Melinda Gates Foundation Vaccine Modelling
Initiative and MRC Centre funding. The analysis was conducted following
a call for proposals initiated and facilitated by GSK Biologicals.
Employees of GSK Biologicals reviewed and commented on early draft
manuscripts, but were not involved in the final approval of the
manuscript. GSK Biologicals did not fund the investigators to undertake
the analysis. GSK funded transport expenses for the investigators to
attend a meeting to discuss their progress. GSK had no role in study
design, data collection or the final decision to publish.
NR 43
TC 43
Z9 43
U1 1
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 16
PY 2013
VL 8
IS 4
AR e61395
DI 10.1371/journal.pone.0061395
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 130DR
UT WOS:000317893400061
PM 23613845
ER
PT J
AU Trappey, AF
Berry, JS
Vreeland, TJ
Hale, DF
Sears, AK
Clifton, G
Ponniah, S
Papamichail, M
Perez, SA
Mittendorf, E
Peoples, GE
AF Trappey, Alfred F.
Berry, John S.
Vreeland, Timothy J.
Hale, Diane F.
Sears, Alan K.
Clifton, Guy
Ponniah, Sathibalan
Papamichail, Michael
Perez, Sonia A.
Mittendorf, Elizabeth
Peoples, George E.
TI Delayed urticarial reactions in the phase II trial of HER2/neu peptide
vaccines plus GM-CSF vs. GM-CSF alone in high risk breast cancer
patients
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 104th Annual Meeting of the American-Association-for-Cancer-Research
(AACR)
CY APR 06-10, 2013
CL Washington, DC
SP Amer Assoc Canc Res
C1 [Trappey, Alfred F.; Berry, John S.; Vreeland, Timothy J.; Hale, Diane F.; Sears, Alan K.; Clifton, Guy; Peoples, George E.] Brooke Army Med Ctr, San Antonio, TX USA.
[Ponniah, Sathibalan] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Papamichail, Michael] Canc Immunol & Immunotherapy Ctr, San Antonio, TX USA.
[Perez, Sonia A.] Canc Immunol & Immunotherapy Ctr, Athens, Greece.
[Mittendorf, Elizabeth] Univ Texas MD Anderson Canc Ctr, Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2013
VL 73
IS 8
SU 1
MA 4670
DI 10.1158/1538-7445.AM2013-4670
PG 1
WC Oncology
SC Oncology
GA AA6PP
UT WOS:000331220604255
ER
PT J
AU Reynolds, JG
Reynolds, CL
Mohanta, A
Muth, JF
Rowe, JE
Everitt, HO
Aspnes, DE
AF Reynolds, J. G.
Reynolds, C. L., Jr.
Mohanta, A.
Muth, J. F.
Rowe, J. E.
Everitt, H. O.
Aspnes, D. E.
TI Shallow acceptor complexes in p-type ZnO
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID CHEMICAL-VAPOR-DEPOSITION; MULTIPLE-QUANTUM WELLS; THIN-FILMS;
OPTICAL-PROPERTIES; PHOTOLUMINESCENCE; EXCITON; ENERGY
AB We show that N-doped ZnO films grown on sapphire can exhibit significant (similar to 10(18) cm(-3)) room-temperature p-type behavior when sufficient nitrogen (N) is incorporated and the material is annealed appropriately. Substitutional N on the oxygen (O) sublattice is a deep acceptor; however, shallow acceptor complexes involve N, H, and zinc vacancies (V-Zn). Combining secondary ion mass spectrometry, Raman-scattering, photoluminescence, and Hall-effect data, we establish the evolution of N from its initial incorporation on a Zn site to a final shallow acceptor complex V-Zn-N-O-H+ with an ionization energy of ca. 130 meV. This complex is responsible for the observed p-type behavior. (C) 2013 AIP Publishing LLC [http://dx.doi.org/10.1063/1.4802753]
C1 [Reynolds, J. G.; Rowe, J. E.; Aspnes, D. E.] N Carolina State Univ, Dept Phys, Raleigh, NC 27695 USA.
[Reynolds, C. L., Jr.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA.
[Mohanta, A.] USA, AMRDEC, Res Participat Program, Oak Ridge Inst Sci & Educ, Redstone Arsenal, AL 35898 USA.
[Muth, J. F.] N Carolina State Univ, Dept Elect & Comp Engn, Monteith Res Ctr, Raleigh, NC 27695 USA.
[Everitt, H. O.] USA, Aviat & Missile RD&E Ctr, CM Bowden Lab, Redstone Arsenal, AL 35898 USA.
[Everitt, H. O.] Duke Univ, Dept Phys, Durham, NC 27705 USA.
RP Reynolds, JG (reprint author), N Carolina State Univ, Dept Phys, 1009 Capability Dr, Raleigh, NC 27695 USA.
RI Everitt, Henry/L-7118-2013; Muth, John/E-9027-2012
OI Everitt, Henry/0000-0002-8141-3768; Muth, John/0000-0002-2488-7721
FU U.S. Army Aviation and Missile Research, Development and Engineering
Center (AMRDEC); Extreme Light Sources DARPA project [W31P4Q-08-1-0003]
FX The authors are pleased to acknowledge Professor Y.-T. Zhu for the use
of his Raman system, Dr. F. Stevie for providing the SIMS depth
profiles, and J. V. Foreman and J. Simmons for their assistance with the
PL measurements. Research was supported in part by an appointment (A.
Mohanta) to the Postgraduate Research Participation Program at the U.S.
Army Aviation and Missile Research, Development and Engineering Center
(AMRDEC) administered by the Oak Ridge Institute for Science and
Education through an interagency agreement between the U.S. Department
of Energy and AMRDEC. We gratefully acknowledge the support from the
Extreme Light Sources DARPA project W31P4Q-08-1-0003 administered by the
University of Florida.
NR 27
TC 40
Z9 45
U1 4
U2 135
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0003-6951
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD APR 15
PY 2013
VL 102
IS 15
AR 152114
DI 10.1063/1.4802753
PG 5
WC Physics, Applied
SC Physics
GA 135EC
UT WOS:000318269200045
ER
PT J
AU Otaki, Y
Gransar, H
Berman, DS
Cheng, VY
Dey, D
Lin, FY
Achenbach, S
Al-Mallah, M
Budoff, MJ
Cademartiri, F
Callister, TQ
Chang, HJ
Chinnaiyan, K
Chow, BJW
Delago, A
Hadamitzky, M
Hausleiter, J
Kaufmann, P
Maffei, E
Raff, G
Shaw, LJ
Villines, TC
Dunning, A
Min, JK
AF Otaki, Yuka
Gransar, Heidi
Berman, Daniel S.
Cheng, Victor Y.
Dey, Damini
Lin, Fay Y.
Achenbach, Stephan
Al-Mallah, Mouaz
Budoff, Matthew J.
Cademartiri, Filippo
Callister, Tracy Q.
Chang, Hyuk-Jae
Chinnaiyan, Kavitha
Chow, Benjamin J. W.
Delago, Augustin
Hadamitzky, Martin
Hausleiter, Joerg
Kaufmann, Philipp
Maffei, Erica
Raff, Gilbert
Shaw, Leslee J.
Villines, Todd C.
Dunning, Allison
Min, James K.
TI Impact of Family History of Coronary Artery Disease in Young Individuals
(from the CONFIRM Registry)
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID MULTIDETECTOR COMPUTED-TOMOGRAPHY; ACUTE MYOCARDIAL-INFARCTION;
MIDDLE-AGED ADULTS; CARDIOVASCULAR-DISEASE; RISK-FACTORS; ANGIOGRAPHY;
PLAQUE; WOMEN; MEN
AB Although family history (FH) of coronary artery disease (CAD) is considered a risk factor for future cardiovascular events, the prevalence, extent, severity, and prognosis of young patients with FH of CAD have been inadequately studied. From 27,125 consecutive patients who underwent coronary computed tomographic angiography, 6,308 young patients (men aged <55 years and women aged <65 years) without known CAD were identified. Obstructive CAD was defined as >50% stenosis in a coronary artery >2 mm diameter. Riskadjusted logistic regression, Kaplan-Meier, and Cox proportional-hazards models were used to compare patients with and without FH of CAD. Compared with subjects without FH of CAD, those with FH of CAD (FH +) had higher prevalences of any CAD (40% vs 30%, p <0.001) and obstructive CAD (11% vs 7%, p <0.001), with multivariate odds of FH + increasing the likelihood of obstructive CAD by 71% (p <0.001). After a mean followup period of 2 1 years (42 myocardial infarctions and 39 all-cause deaths), FH + patients experienced higher annual rates of myocardial infarction (0.5% vs 0.2%, log-rank p = 0.001), with a positive FH the strongest predictor of myocardial infarction (hazard ratio 2.6, 95% confidence interval 1.4 to 4.8, p = 0.002). In conclusion, young FH + patients have higher presence, extent, and severity of CAD, which are associated with increased risk for myocardial infarction. Compared with other clinical CAD risk factors, positive FH in young patients is the strongest clinical predictor of future unheralded myocardial infarction. 2013 Elsevier Inc. All rights reserved. (Am J Cardiol 2013;111:1081-1086)
C1 [Otaki, Yuka; Gransar, Heidi; Berman, Daniel S.; Cheng, Victor Y.; Dey, Damini; Min, James K.] Cedars Sinai Heart Inst, Dept Imaging, Los Angeles, CA USA.
[Otaki, Yuka; Gransar, Heidi; Berman, Daniel S.; Cheng, Victor Y.; Dey, Damini; Min, James K.] Cedars Sinai Heart Inst, Dept Med, Los Angeles, CA USA.
[Dey, Damini] Cedars Sinai Med Ctr, Dept Biomed Sci, Los Angeles, CA 90048 USA.
[Dey, Damini] Cedars Sinai Med Ctr, Biomed Imaging Res Inst, Los Angeles, CA 90048 USA.
[Berman, Daniel S.; Cheng, Victor Y.; Dey, Damini; Min, James K.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA.
[Lin, Fay Y.] Weill Cornell Med Coll, Dept Med, New York, NY USA.
[Dunning, Allison] Weill Cornell Med Coll, Dept Publ Hlth, New York, NY USA.
New York Presbyterian Hosp, New York, NY USA.
[Achenbach, Stephan] Univ Erlangen Nurnberg, Dept Med, D-91054 Erlangen, Germany.
[Al-Mallah, Mouaz] Wayne State Univ, Dept Med, Henry Ford Hosp, Detroit, MI 48202 USA.
[Budoff, Matthew J.] Harbor UCLA Med Ctr, Dept Med, Los Angeles, CA USA.
[Cademartiri, Filippo; Maffei, Erica] Giovanni XXIII Hosp, Cardiovasc Imaging Unit, Monastier, Italy.
[Cademartiri, Filippo; Maffei, Erica] Erasmus MC, Dept Radiol, Rotterdam, Netherlands.
[Callister, Tracy Q.] Tennessee Heart & Vasc Inst, Hendersonville, TN USA.
[Chang, Hyuk-Jae] Severance Cardiovasc Hosp, Div Cardiol, Seoul, South Korea.
[Chinnaiyan, Kavitha; Raff, Gilbert] William Beaumont Hosp, Royal Oak, MI 48072 USA.
[Chow, Benjamin J. W.] Univ Ottawa, Dept Med & Radiol, Ottawa, ON, Canada.
[Delago, Augustin] Capitol Cardiol Associates, Albany, NY USA.
[Hadamitzky, Martin; Hausleiter, Joerg] Deutsch Herzzentrum Munich, Div Cardiol, Munich, Germany.
[Kaufmann, Philipp] Univ Zurich Hosp, CH-8091 Zurich, Switzerland.
[Shaw, Leslee J.] Emory Univ, Sch Med, Dept Med, Atlanta, GA USA.
[Villines, Todd C.] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA.
RP Min, JK (reprint author), Cedars Sinai Heart Inst, Dept Imaging, Los Angeles, CA USA.
EM james.min@cshs.org
RI Cademartiri, Filippo/H-7336-2015; Maffei, Erica/J-2370-2016;
OI Cademartiri, Filippo/0000-0002-0579-3279; Maffei,
Erica/0000-0002-0388-4433; Villines, Todd/0000-0003-2674-3702;
Al-Mallah, Mouaz/0000-0003-2348-0484
NR 26
TC 11
Z9 12
U1 0
U2 6
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD APR 15
PY 2013
VL 111
IS 8
BP 1081
EP 1086
DI 10.1016/j.amjcard.2012.12.042
PG 6
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA 130CK
UT WOS:000317890100001
PM 23411105
ER
PT J
AU Goertz, CM
Long, CR
Hondras, MA
Petri, R
Delgado, R
Lawrence, DJ
Owens, EF
Meeker, WC
AF Goertz, Christine M.
Long, Cynthia R.
Hondras, Maria A.
Petri, Richard
Delgado, Roxana
Lawrence, Dana J.
Owens, Edward F., Jr.
Meeker, William C.
TI Adding Chiropractic Manipulative Therapy to Standard Medical Care for
Patients With Acute Low Back Pain Results of a Pragmatic Randomized
Comparative Effectiveness Study
SO SPINE
LA English
DT Article
DE low back pain; chiropractic manipulation; military medicine; physical
functioning
ID SPINAL MANIPULATION; MANAGEMENT; OUTCOMES
AB Study Design. Randomized controlled trial.
Objective. To assess changes in pain levels and physical functioning in response to standard medical care (SMC) versus SMC plus chiropractic manipulative therapy (CMT) for the treatment of low back pain (LBP) among 18 to 35-year-old active-duty military personnel.
Summary of Background Data. LBP is common, costly, and a significant cause of long-term sick leave and work loss. Many different interventions are available, but there exists no consensus on the best approach. One intervention often used is manipulative therapy. Current evidence from randomized controlled trials demonstrates that manipulative therapy may be as effective as other conservative treatments of LBP, but its appropriate role in the healthcare delivery system has not been established.
Methods. Prospective, 2-arm randomized controlled trial pilot study comparing SMC plus CMT with only SMC. The primary outcome measures were changes in back-related pain on the numerical rating scale and physical functioning at 4 weeks on the Roland-Morris Disability Questionnaire and back pain functional scale (BPFS).
Results. Mean Roland-Morris Disability Questionnaire scores decreased in both groups during the course of the study, but adjusted mean scores were significantly better in the SMC plus CMT group than in the SMC group at both week 2 (P < 0.001) and week 4 (P = 0.004). Mean numerical rating scale pain scores were also significantly better in the group that received CMT. Adjusted mean back pain functional scale scores were significantly higher (improved) in the SMC plus CMT group than in the SMC group at both week 2 (P < 0.001) and week 4 (P = 0.004).
Conclusion. The results of this trial suggest that CMT in conjunction with SMC offers a significant advantage for decreasing pain and improving physical functioning when compared with only standard care, for men and women between 18 and 35 years of age with acute LBP.
C1 [Goertz, Christine M.; Long, Cynthia R.; Hondras, Maria A.] Palmer Ctr Chiropract Res, Davenport, IA 52803 USA.
[Petri, Richard] Phys Med & Integrat Care Serv, Ft Bliss, TX USA.
[Delgado, Roxana] Samueli Inst, Alexandria, VA USA.
[Lawrence, Dana J.] Palmer Coll Chiropract, Davenport, IA USA.
[Owens, Edward F., Jr.] TriMax Direct, St Paul, MN USA.
[Meeker, William C.] Palmer Coll Chiropract, San Jose, CA USA.
RP Goertz, CM (reprint author), Palmer Ctr Chiropract Res, 741 Brady St, Davenport, IA 52803 USA.
EM christine.goertz@palmer.edu
OI Goertz, Christine/0000-0002-4700-3669
FU Samueli Institute; National Center for Research Resources, National
Institutes of Health [C06 RR15433]
FX Samueli Institute grant funds were received to support this work. Some
of this work was conducted in a facility constructed with support from
Research Facilities Improvement Grant (C06 RR15433) from the National
Center for Research Resources, National Institutes of Health.
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U2 24
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0362-2436
J9 SPINE
JI SPINE
PD APR 15
PY 2013
VL 38
IS 8
BP 627
EP 634
DI 10.1097/BRS.0b013e31827733e7
PG 8
WC Clinical Neurology; Orthopedics
SC Neurosciences & Neurology; Orthopedics
GA 125TY
UT WOS:000317565400010
PM 23060056
ER
PT J
AU Wei, M
Boutwell, RC
Garrett, GA
Goodman, K
Rotella, P
Schoenfeld, WV
AF Wei, M.
Boutwell, R. C.
Garrett, G. A.
Goodman, K.
Rotella, P.
Schoenfeld, W. V.
TI Optimization of photoluminescence lifetime for ZnO films grown on ZnO
substrates at low temperature
SO MATERIALS LETTERS
LA English
DT Article
DE ZnO; Epitaxial growth; Homoepitaxy; Photoluminescence lifetime;
Structural; Defects
ID SINGLE-CRYSTAL; POLAR
AB ZnO films were grown on Zn-polar ZnO substrates with 0.5 degrees miscut toward the [1EQ \O(1,-)00] direction by plasma-assisted molecular beam epitaxy (PAMBE). An atomically flat surface with one or two monolayer step height along the [0001] direction was achieved at low. growth temperature. Wet etching of the substrates and ozone exposure reduced defects and improved photoluminescence (PL) lifetime by a factor of two. A 20 min interval between oxygen plasma ignition and growth was found necessary for excellent crystallinity and yielded high PL lifetimes of 0.179 ns. By decreasing the growth temperature in the low temperature range, the growth rate was increased from 0.02 mu m/h to 0.246 mu m/h, and correspondingly PL lifetime was improved by an order of magnitude, from 0.018 ns to 0.3 ns. (c) 2013 Elsevier B.V. All rights reserved.
C1 [Wei, M.; Boutwell, R. C.; Schoenfeld, W. V.] Univ Cent Florida, CREOL, Coll Opt & Photon, Orlando, FL 32816 USA.
[Garrett, G. A.; Goodman, K.; Rotella, P.] USA, Res Lab, RDRL SEE M, Adelphi, MD 20783 USA.
RP Schoenfeld, WV (reprint author), Univ Cent Florida, CREOL, Coll Opt & Photon, 4000 Cent Florida Blvd, Orlando, FL 32816 USA.
EM winston@creol.ucf.edu
OI Boutwell, Ryan/0000-0003-2321-1495
FU Army Research Laboratory under Cooperative Agreement [W911NF-11-2-0025]
FX The authors would like to acknowledge financial support of this work by
the Army Research Laboratory under Cooperative Agreement number
W911NF-11-2-0025.
NR 14
TC 1
Z9 1
U1 0
U2 47
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-577X
J9 MATER LETT
JI Mater. Lett.
PD APR 15
PY 2013
VL 97
BP 11
EP 14
DI 10.1016/j.matlet.2013.01.090
PG 4
WC Materials Science, Multidisciplinary; Physics, Applied
SC Materials Science; Physics
GA 120IS
UT WOS:000317164600004
ER
PT J
AU Florio, LA
AF Florio, L. A.
TI Direct particle motion and interaction modeling method applied to
simulate propellant burn
SO APPLIED MATHEMATICAL MODELLING
LA English
DT Article
DE Computational; Fluid; Particle; Propellant burn
ID GRANULATED PROPELLANTS; NUMERICAL-SIMULATION; TURBULENT FLOWS; TRANSIENT
FLOW; COMBUSTION; SYSTEM; FIELD
AB A direct particle motion and particle interaction modeling method was developed to provide an alternative means of capturing the fundamental phenomena occurring during the burning of propellant grains. Individual propellant grains and other moving components are directly incorporated into the computational domain, removing the need for correlations for particle drag and interaction effects. The motion of the individual particles is calculated from the locally acting fluid induced and collision effect forces and moments. Particle/object interactions are handled through a soft particle collision algorithm. Localized mass and energy sources, accompanied by a shrinking particle size, simulate the effects of the combustion process.
The method is applied to the burning of propellant in a two-dimensional planar gun type system. Parametric studies were performed varying the parameters related to the propellant and projectile to explore the capabilities of the current modeling method and to determine the sensitivity of the gas, propellant, and projectile conditions. The model captured the local pressure waves moving between the breech and the bullet base not observed using a bulk effect model. The results also indicated that the conditions in the system that are most sensitive to the burn rate exponent where a 24% increase in the exponent produced a 200% increase in the peak pressure at the breech. The study demonstrated the utility of this new model in exploring in particular the localized phenomena and conditions that develop during the burning of propellant. Published by Elsevier Inc.
C1 USA, ARDEC, Technol Branch, Small Caliber Armaments Div,RDAR WSW F, Picatinny Arsenal, NJ 07806 USA.
RP Florio, LA (reprint author), USA, ARDEC, Technol Branch, Small Caliber Armaments Div,RDAR WSW F, Bldg 8, Picatinny Arsenal, NJ 07806 USA.
EM laurie.a.florio.civ@mail.mil
FU Joint Service Small Arms Program (JSSAP) Office
FX This work was funded by the Joint Service Small Arms Program (JSSAP)
Office.
NR 48
TC 6
Z9 6
U1 1
U2 13
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0307-904X
J9 APPL MATH MODEL
JI Appl. Math. Model.
PD APR 15
PY 2013
VL 37
IS 8
BP 5606
EP 5626
DI 10.1016/j.apm.2012.10.030
PG 21
WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary
Applications; Mechanics
SC Engineering; Mathematics; Mechanics
GA 114VA
UT WOS:000316769600003
ER
PT J
AU Yeager, JD
Ramos, KJ
Pesce-Rodriguez, RA
Piraino, SM
AF Yeager, J. D.
Ramos, K. J.
Pesce-Rodriguez, R. A.
Piraino, S. M.
TI Microstructural effects of processing in the plastic-bonded explosive
Composition A-3
SO MATERIALS CHEMISTRY AND PHYSICS
LA English
DT Article
DE Composite materials; Interfaces; Neutron reflectivity; Secondary ion
mass spectroscopy (SMS); Microstructure
ID NEUTRON REFLECTOMETRY; ENERGETIC MATERIALS; INTERFACE; NANOINDENTATION;
DEFORMATION; MORPHOLOGY; PARTICLES; PBX-9501; POLYMERS; CRYSTAL
AB Multiscale model development for composites such as plastic-bonded explosives (PBXs) is critical for assessing structural integrity and behavior and for developing new materials. For models to be successful they must reproduce bulk material responses while incorporating important microstructural features. These features arise at the mesoscale during processing, and while they have commensurate effects on composite material response they are not easily identified or characterized. Here, we study Composition A-3 as a representative PBX, chosen both for relevance to the field and as a tractable formulation to model. Composition A-3 is formulated by mixing micron-scale explosive crystals with an emulsified polyethylene solution, then breaking the emulsion to form small crystal/polyethylene agglomerates suitable for pressing and machining. Key aspects of this formulation process that may potentially affect the microstructure were identified. Specifically, the emulsification chemicals in a model system were found to partially dissolve or degrade the explosive and create a diffuse interface between the crystal and binder. The diffuse interfaces, along with some of the chemicals that remain in the composite after manufacture, create a heterogeneous multicomponent system that likely influences adhesion, void formation, and crack formation. The observed interfaces may be difficult to model. These results are compared with previous interfacial studies in other PBX materials, and the necessity of including such data in mesoscale models is discussed. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Yeager, J. D.; Ramos, K. J.] Los Alamos Natl Lab, Los Alamos, NM 87545 USA.
[Pesce-Rodriguez, R. A.; Piraino, S. M.] USA, Res Lab, ATTN RDRL WML B, Aberdeen Proving Ground, MD 21005 USA.
RP Yeager, JD (reprint author), Los Alamos Natl Lab, POB 1663,MS P952, Los Alamos, NM 87545 USA.
EM jyeager@lanl.gov; kramos@lanl.gov; rose.a.pesce-rodriguez.civ@mail.mil;
stephanie.m.piraino-haynes.civ@mail.mil
OI Yeager, John/0000-0002-3121-6053
FU National Nuclear Security Administration Science Campaign 2; Agnew
National Security Fellowship; Lethality Division of the Weapons and
Materials Research Directorate; National Nuclear Security Administration
of the U.S. Department of Energy [DE-AC52-06NA25396]
FX Los Alamos National Laboratory is operated by LANS LLC for the
Department of Energy. Funding for work at Los Alamos was provided by the
National Nuclear Security Administration Science Campaign 2, and JDY is
supported by an Agnew National Security Fellowship. Funding for work at
the Army Research Laboratory was provided by the Lethality Division of
the Weapons and Materials Research Directorate. This work was performed,
in part, at the Center for Integrated Nanotechnologies, a U.S.
Department of Energy, Office of Basic Energy Sciences user facility. Los
Alamos National Laboratory, an affirmative action equal opportunity
employer, is operated by Los Alamos National Security, LLC, for the
National Nuclear Security Administration of the U.S. Department of
Energy under contract DE-AC52-06NA25396. We thank J. Majewski and S.
Singh (LANL) for assistance with the neutron reflectometry measurements,
and D. Hooks (LANL) for helpful discussion and technical editing.
NR 43
TC 2
Z9 3
U1 2
U2 36
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0254-0584
J9 MATER CHEM PHYS
JI Mater. Chem. Phys.
PD APR 15
PY 2013
VL 139
IS 1
BP 305
EP 313
DI 10.1016/j.matchemphys.2013.01.041
PG 9
WC Materials Science, Multidisciplinary
SC Materials Science
GA 111KJ
UT WOS:000316519900043
ER
PT J
AU Montain, SJ
McGraw, SM
Ely, MR
Grier, TL
Knapik, JJ
AF Montain, Scott J.
McGraw, Susan M.
Ely, Matthew R.
Grier, Tyson L.
Knapik, Joseph J.
TI A retrospective cohort study on the influence of UV index and
race/ethnicity on risk of stress and lower limb fractures
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Article
DE Bone health; Vitamin D; Risk factors; Military
ID SERUM 25-HYDROXYVITAMIN D; VITAMIN-D INSUFFICIENCY; HIP FRACTURE;
UNITED-STATES; HIGH PREVALENCE; PREGNANT-WOMEN; D DEFICIENCY;
LIFE-STYLE; POPULATION; RECRUITS
AB Background: Low vitamin D status increases the risk of stress fractures. As ultraviolet (UV) light is required for vitamin D synthesis, low UV light availability is thought to increase the risk of vitamin D insufficiency and poor bone health. The purpose of this investigation was to determine if individuals with low UV intensity at their home of record (HOR) or those with darker complexions are at increased risk of developing stress fractures and lower limb fractures during U.S. Army Basic Combat Training (BCT).
Methods: This was a retrospective cohort study using the Armed Forces Health Surveillance Center data repository. All Basic trainees were identified from January 1997 to January 2007. Cases were recruits diagnosed with stress fractures and lower limb fractures during BCT. The recruit's home of record (HOR) was identified from the Defense Manpower Data Center database. The average annual UV intensity at the recruits' HOR was determined using a U.S National Weather Service database and recruits were stratified into low (<= 3.9); moderate (4.0-5.4), and high (>= 5.5) UV index regions. Race was determined from self-reports.
Results: The dataset had 421,461 men and 90,141women. Compared to men, women had greater risk of developing stress fractures (odds ratio (OR) = 4.5, 95% confidence interval (95%CI) = 4.4-4.7, p < 0.01). Contrary to the hypothesized effect, male and female recruits from low UV index areas had a slightly lower risk of stress fractures (male OR (low UV/high UV) = 0.92, 95%CI = 0.87-0.97; females OR = 0.89, 95%CI = 0.84-0.95, p < 0.01) and were at similar risk for lower limb fractures (male OR = 0.98, 95%CI = 0.89-1.07; female OR = 0.93, 95%CI = 0.80-1.09) than recruits from high UV index areas. Blacks had lower risk of stress and lower limb fractures than non-blacks, and there was no indication that Blacks from low UV areas were at increased risk for bone injuries.
Conclusions: The UV index at home of record is not associated with stress or lower limb fractures in BCT. These data suggest that UV intensity is not a risk factor for poor bone health in younger American adults.
C1 [Montain, Scott J.; McGraw, Susan M.; Ely, Matthew R.] USA, Environm Med Res Inst, Natick, MA 01760 USA.
[Grier, Tyson L.; Knapik, Joseph J.] USA, Inst Publ Hlth, Aberdeen Proving Ground, MD USA.
RP Montain, SJ (reprint author), USA, Environm Med Res Inst, Bldg 42,Kansas St, Natick, MA 01760 USA.
EM scott.montain@us.army.mil
OI Ely, Matthew/0000-0002-0618-7078
NR 31
TC 3
Z9 3
U1 1
U2 11
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD APR 12
PY 2013
VL 14
AR 135
DI 10.1186/1471-2474-14-135
PG 9
WC Orthopedics; Rheumatology
SC Orthopedics; Rheumatology
GA 140AF
UT WOS:000318625900001
PM 23587313
ER
PT J
AU Petr, M
Katzman, BA
DiNatale, W
Hammond, PT
AF Petr, Michael
Katzman, Bat-ami
DiNatale, William
Hammond, Paula T.
TI Synthesis of a New, Low-T-g Siloxane Thermoplastic Elastomer with a
Functionalizable Backbone and Its Use as a Rapid, Room Temperature
Photoactuator
SO MACROMOLECULES
LA English
DT Article
ID LIQUID-CRYSTALLINE POLYMERS; FREE-RADICAL POLYMERIZATION; TRIBLOCK
COPOLYMER GELS; BLOCK-COPOLYMERS; DIBLOCK COPOLYMERS;
MECHANICAL-PROPERTIES; PHASE-TRANSITIONS; X-RAY; AZOBENZENE; MORPHOLOGY
AB A new, low-T-g siloxane thermoplastic elastomer with a functionalizable backbone was synthesized via sequential anionic polymerization and coupling, and its utility as a platform to produce functional elastomers was demonstrated by the attachment of a photoresponsive liquid crystal to produce a rapid, room temperature photoactuator. Polystyrene was used as a hard glassy end block, and poly(vinylmethylsiloxane) served as the soft middle segment in a polystyrene-b-poly(vinylmethylsiloxane)-b-polystyrene ABA triblock copolymer. The vinyl side chain was used to attach a side on oriented mesogen to the siloxane backbone, and the resulting liquid crystal triblock copolymer was characterized with reversible photocontraction tests, where it was shown to be both elastomeric and rapidly photoresponsive at room temperature. Rather than simply undergoing a bending mechanism, an oriented thin cast film of the elastomer was observed to contract reversibly at a tensile strain of 3.3% against 253 kPa of applied stress in similar to 5.9 s. This strategy to produce functional liquid crystal elastomers is based on the formation of spherical block copolymers with a low temperature T-g for the soft domain, in contrast to cross linked elastomers. Because the approach is simple, robust, and applicable to a wide variety of functional moieties, the resulting materials are thermoplastics that can be processed to achieve preferential orientation using standard methods, thus enhancing the capability to produce and utilize functional actuators.
C1 [Petr, Michael; Katzman, Bat-ami; Hammond, Paula T.] MIT, Dept Chem Engn, Cambridge, MA 02139 USA.
[DiNatale, William] USA, Res Off, Inst Soldier Nanotechnol, Cambridge, MA 02139 USA.
RP Hammond, PT (reprint author), MIT, Dept Chem Engn, Cambridge, MA 02139 USA.
EM hammond@mit.edu
OI Gordon, Bat-ami/0000-0002-1775-7849
FU U.S. Army Research Office [W911NF-07-D-0004]
FX The authors of this paper thank the U.S. Army Research Office for
financial support of this research under Contract W911NF-07-D-0004.
NR 82
TC 16
Z9 16
U1 7
U2 137
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0024-9297
EI 1520-5835
J9 MACROMOLECULES
JI Macromolecules
PD APR 9
PY 2013
VL 46
IS 7
BP 2823
EP 2832
DI 10.1021/ma400031z
PG 10
WC Polymer Science
SC Polymer Science
GA 124BH
UT WOS:000317438300033
ER
PT J
AU Graham, BS
Enama, ME
Nason, MC
Gordon, IJ
Peel, SA
Ledgerwood, JE
Plummer, SA
Mascola, JR
Bailer, RT
Roederer, M
Koup, RA
Nabel, GJ
AF Graham, Barney S.
Enama, Mary E.
Nason, Martha C.
Gordon, Ingelise J.
Peel, Sheila A.
Ledgerwood, Julie E.
Plummer, Sarah A.
Mascola, John R.
Bailer, Robert T.
Roederer, Mario
Koup, Richard A.
Nabel, Gary J.
CA VRC 008 Study Team
TI DNA Vaccine Delivered by a Needle-Free Injection Device Improves Potency
of Priming for Antibody and CD8+T-Cell Responses after rAd5 Boost in a
Randomized Clinical Trial
SO PLOS ONE
LA English
DT Article
ID HEPATITIS-A VACCINE; T-CELL RESPONSES; NEUTRALIZING ANTIBODY; CANDIDATE
VACCINE; HEALTHY-ADULTS; IMMUNOGENICITY EVALUATION; PHASE-1 SAFETY; JET
INJECTION; PLASMID DNA; HIV-1
AB Background: DNA vaccine immunogenicity has been limited by inefficient delivery. Needle-free delivery of DNA using a CO2-powered Biojector (R) device was compared to delivery by needle and syringe and evaluated for safety and immunogenicity.
Methods: Forty adults, 18-50 years, were randomly assigned to intramuscular (IM) vaccinations with DNA vaccine, VRC-HIVDNA016-00-VP, (weeks 0, 4, 8) by Biojector (R) 2000 (TM) or needle and syringe (N/S) and boosted IM at week 24 with VRC-HIVADV014-00-VP (rAd5) with N/S at 10(10) or 10(11) particle units (PU). Equal numbers per assigned schedule had low (<= 500) or high (>500) reciprocal titers of preexisting Ad5 neutralizing antibody.
Results: 120 DNA and 39 rAd5 injections were given; 36 subjects completed follow-up research sample collections. IFN-gamma ELISpot response rates were 17/19 (89%) for Biojector (R) and 13/17 (76%) for N/S delivery at Week 28 (4 weeks post rAd5 boost). The magnitude of ELISpot response was about 3-fold higher in Biojector (R) compared to N/S groups. Similar effects on response rates and magnitude were observed for CD8+, but not CD4+ T-cell responses by ICS. Env-specific antibody responses were about 10-fold higher in Biojector-primed subjects.
Conclusions: DNA vaccination by Biojector (R) was well-tolerated and compared to needle injection, primed for greater IFN-gamma ELISpot, CD8+ T-cell, and antibody responses after rAd5 boosting.
Trial Registration: ClinicalTrials.gov NCT00109629
C1 [Graham, Barney S.; Enama, Mary E.; Gordon, Ingelise J.; Ledgerwood, Julie E.; Plummer, Sarah A.; Mascola, John R.; Bailer, Robert T.; Roederer, Mario; Koup, Richard A.; Nabel, Gary J.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
[Nason, Martha C.] NIAID, Biostat Res Branch, Div Clin Res, NIH, Bethesda, MD 20892 USA.
[Peel, Sheila A.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
RP Graham, BS (reprint author), NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM bgraham@nih.gov
FU National Institute of Allergy and Infectious Diseases (NIAID)
FX Funding for the conduct of this clinical trial was provided by the
National Institute of Allergy and Infectious Diseases (NIAID) intramural
research program. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
NR 34
TC 20
Z9 21
U1 0
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 8
PY 2013
VL 8
IS 4
AR e59340
DI 10.1371/journal.pone.0059340
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 130FG
UT WOS:000317898000011
PM 23577062
ER
PT J
AU Hindenlang, MD
Knorr, DB
Lenhart, JL
AF Hindenlang, Mark D.
Knorr, Daniel B.
Lenhart, Joseph L.
TI Improvement of polymer dielectric materials
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 245th National Spring Meeting of the American-Chemical-Society (ACS)
CY APR 07-11, 2013
CL New Orleans, LA
SP Amer Chem Soc
C1 [Hindenlang, Mark D.; Knorr, Daniel B.; Lenhart, Joseph L.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM mark.hindenlang.ctr@mail.mil
NR 0
TC 0
Z9 0
U1 1
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD APR 7
PY 2013
VL 245
MA 517-POLY
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 216SF
UT WOS:000324303605039
ER
PT J
AU Hindenlang, MD
Knorr, DB
Richardson, A
Lenhart, JL
AF Hindenlang, Mark D.
Knorr, Daniel B.
Richardson, Adam
Lenhart, Joseph L.
TI Rate dependent response of crosslinked epoxy networks
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 245th National Spring Meeting of the American-Chemical-Society (ACS)
CY APR 07-11, 2013
CL New Orleans, LA
SP Amer Chem Soc
C1 [Hindenlang, Mark D.; Knorr, Daniel B.; Richardson, Adam; Lenhart, Joseph L.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM mark.hindenlang.ctr@mail.mil
NR 0
TC 0
Z9 0
U1 1
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD APR 7
PY 2013
VL 245
MA 554-PMSE
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 216SF
UT WOS:000324303604505
ER
PT J
AU Hu, WG
Hsieh, AJ
AF Hu, Weiguo
Hsieh, Alex J.
TI Solid-state NMR characterization of a select model poly(urethane urea)
elastomer
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 245th National Spring Meeting of the American-Chemical-Society (ACS)
CY APR 07-11, 2013
CL New Orleans, LA
SP Amer Chem Soc
C1 [Hu, Weiguo] Univ Massachusetts, Dept Polymer Sci & Engn, Amherst, MA 01003 USA.
[Hsieh, Alex J.] US Army Res Lab, RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA.
EM weiguoh@polysci.umass.edu
NR 0
TC 0
Z9 0
U1 0
U2 3
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD APR 7
PY 2013
VL 245
MA 482-POLY
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 216SF
UT WOS:000324303605002
ER
PT J
AU Ilgen, A
Majs, F
Barker, A
Douglas, T
Trainor, T
AF Ilgen, Anastasia
Majs, Frantisek
Barker, Amanda
Douglas, Thomas
Trainor, Thomas
TI Oxidation and mobilization of metallic antimony in aqueous systems with
simulated ground water
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 245th National Spring Meeting of the American-Chemical-Society (ACS)
CY APR 07-11, 2013
CL New Orleans, LA
SP Amer Chem Soc
C1 [Ilgen, Anastasia] Sandia Natl Labs, Dept Geochem, Albuquerque, NM 87185 USA.
[Majs, Frantisek; Barker, Amanda; Trainor, Thomas] Univ Alaska Fairbanks, Dept Chem & Biochem, Fairbanks, AK 99775 USA.
[Douglas, Thomas] US Army Corps Engineers, Cold Reg Res & Engn Lab, Fairbanks, AK 99709 USA.
EM agilgen@sandia.gov
NR 0
TC 0
Z9 0
U1 0
U2 4
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD APR 7
PY 2013
VL 245
MA 116-GEOC
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 216SF
UT WOS:000324303600363
ER
PT J
AU Mahdavian, E
Williams-Hart, T
Furmanski, B
Liu, YY
Kevil, C
Clifford, J
Salvatore, B
AF Mahdavian, Elahe
Williams-Hart, Tara
Furmanski, Brian
Liu, Yong-Yu
Kevil, Christopher
Clifford, John
Salvatore, Brian
TI Evaluation of Fusarochromanone: A potent anticancer agent
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 245th National Spring Meeting of the American-Chemical-Society (ACS)
CY APR 07-11, 2013
CL New Orleans, LA
SP Amer Chem Soc
C1 [Mahdavian, Elahe; Williams-Hart, Tara; Salvatore, Brian] LSU Shreveport, Shreveport, LA 71115 USA.
[Furmanski, Brian] St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA.
[Liu, Yong-Yu] NE Louisiana Univ, Dept Basic Pharmaceut Sci, Monroe, LA 71209 USA.
[Kevil, Christopher] LSUHSC Shreveport, Dept Pathol, Shreveport, LA USA.
[Clifford, John] US Army Inst Surg Res, Battlefield Pain Control Res Program, Ft Sam Houston, TX 78234 USA.
EM emahdavi@lsus.edu
NR 0
TC 0
Z9 0
U1 0
U2 3
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD APR 7
PY 2013
VL 245
MA 334-MEDI
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 216SF
UT WOS:000324303602353
ER
PT J
AU Satapathi, S
Yadav, P
Kumari, M
Li, L
Samuelson, LA
Kumar, J
Sharma, SK
AF Satapathi, Soumitra
Yadav, Preeti
Kumari, Meena
Li, Lian
Samuelson, Lynne A.
Kumar, Jayant
Sharma, Sunil K.
TI Two-photon active coumarins for high contrast imaging of cancer cells
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 245th National Spring Meeting of the American-Chemical-Society (ACS)
CY APR 07-11, 2013
CL New Orleans, LA
SP Amer Chem Soc
C1 [Satapathi, Soumitra; Kumar, Jayant] Univ Maasachusetts Lowell, Ctr Adv Mat, Lowell, MA 01854 USA.
[Yadav, Preeti; Kumari, Meena] Univ Delhi, Dept Chem, New Delhi 110007, India.
[Li, Lian; Samuelson, Lynne A.; Sharma, Sunil K.] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA.
EM soumitrasatapathi@gmail.com
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD APR 7
PY 2013
VL 245
MA 307-MEDI
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 216SF
UT WOS:000324303602327
ER
PT J
AU St John, JM
Tran, DT
Oliver, SRJ
AF St John, Jessica M.
Tran, Dat T.
Oliver, Scott R. J.
TI High surface area materials for the selective desulfurization of JP-8
fuel
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 245th National Spring Meeting of the American-Chemical-Society (ACS)
CY APR 07-11, 2013
CL New Orleans, LA
SP Amer Chem Soc
C1 [St John, Jessica M.; Oliver, Scott R. J.] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA.
[Tran, Dat T.] US Army Res Lab, RDRL SED C, Adelphi, MD 20783 USA.
EM jstjohn@ucsc.edu
NR 0
TC 0
Z9 0
U1 0
U2 5
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD APR 7
PY 2013
VL 245
MA 1282-INOR
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 216SF
UT WOS:000324303601040
ER
PT J
AU Bhandari, RK
Oda, RP
Petrikovics, I
Bebarta, VS
Mohan, SB
Brenner, M
Rockwood, GA
Logue, BA
AF Bhandari, Raj K.
Oda, Robert P.
Petrikovics, Ilona
Bebarta, Vikhyat S.
Mohan, Sari B.
Brenner, Matthew
Rockwood, Gary A.
Logue, Brian A.
TI Toxicokinetics of cyanide, thiocyanate and
2-amino-2-thiazoline-4-carboxylic acid (ATCA) by simultaneous analysis
using ultra-high performance liquid chromatography-tandem mass
spectrometry (UHPLC-MS-MS)
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 245th National Meeting of the American-Chemical-Society (ACS)
CY APR 07-11, 2013
CL New Orleans, LA
SP Amer Chem Soc
C1 [Bhandari, Raj K.; Oda, Robert P.; Logue, Brian A.] S Dakota State Univ, Dept Chem & Biochem, Brookings, SD 57007 USA.
[Petrikovics, Ilona] Sam Houston State Univ, Dept Chem, Huntsville, TX 77341 USA.
[Mohan, Sari B.] Univ Calif Irvine, Beckman Laser Inst, Irvine, CA 92612 USA.
[Mohan, Sari B.] Univ Calif Irvine, Med Clin, Laser Microbeam & Med Program, Irvine, CA 92612 USA.
[Brenner, Matthew] Univ Calif Irvine, Div Pulm & Crit Care Med, Dept Med, Irvine, CA 92868 USA.
[Bebarta, Vikhyat S.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
[Rockwood, Gary A.] US Army Med Res Inst Chem Def, Div Analyt Toxicol, Aberdeen Proving Ground, MD 21010 USA.
EM raj.bhandari@sdstate.edu
RI Bebarta, Vikhyat/M-1513-2015; bebarta, vikhyat/K-3476-2015
NR 0
TC 0
Z9 0
U1 0
U2 3
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD APR 7
PY 2013
VL 245
MA 15-ANYL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 210RD
UT WOS:000323851300365
ER
PT J
AU Borodin, O
Xing, LD
Jow, R
AF Borodin, Oleg
Xing, Lidan
Jow, Richard
TI Electrolyte oxidative stability: Decomposition pathways and transport
properties
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 245th National Meeting of the American-Chemical-Society (ACS)
CY APR 07-11, 2013
CL New Orleans, LA
SP Amer Chem Soc
C1 [Borodin, Oleg; Jow, Richard] Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA.
[Xing, Lidan] Univ Utah, Salt Lake City, UT 84112 USA.
EM olegutah@gmail.com
RI Borodin, Oleg/B-6855-2012
OI Borodin, Oleg/0000-0002-9428-5291
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD APR 7
PY 2013
VL 245
MA 448-COMP
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 210RD
UT WOS:000323851304443
ER
PT J
AU Demeritte, T
Ray, P
Dubey, M
Zarkar, E
AF Demeritte, Teresa
Ray, Paresh
Dubey, Madan
Zarkar, Eugene
TI Direct detection of explosive TNT using popcorn shape gold nanoparticle
attached SWCNT hybrid
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 245th National Meeting of the American-Chemical-Society (ACS)
CY APR 07-11, 2013
CL New Orleans, LA
SP Amer Chem Soc
C1 [Demeritte, Teresa; Ray, Paresh] Jackson State Univ, Jackson, MS 39217 USA.
[Dubey, Madan; Zarkar, Eugene] US Army Res Lab, Adelphi, MD 20783 USA.
EM teresademeritte@gmail.com
NR 0
TC 0
Z9 0
U1 0
U2 3
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD APR 7
PY 2013
VL 245
MA 33-ANYL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 210RD
UT WOS:000323851300541
ER
PT J
AU Harrell, JE
Gutteridge, CE
Sadowski, BW
O'Neil, MT
Lee, P
AF Harrell, Jonathan E.
Gutteridge, Clare E.
Sadowski, Brett W.
O'Neil, Michael T.
Lee, Patricia
TI Preparation novel compounds with activity against the malaria parasite,
Plasmodium falciparum
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 245th National Meeting of the American-Chemical-Society (ACS)
CY APR 07-11, 2013
CL New Orleans, LA
SP Amer Chem Soc
C1 [Harrell, Jonathan E.; Gutteridge, Clare E.; Sadowski, Brett W.] US Naval Acad, Dept Chem, Annapolis, MD 21402 USA.
[O'Neil, Michael T.; Lee, Patricia] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA.
EM gutterid@usna.edu
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD APR 7
PY 2013
VL 245
MA 807-CHED
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 210RD
UT WOS:000323851302604
ER
PT J
AU Henderson, WA
Seo, DM
Han, SD
Allen, JL
Borodin, O
AF Henderson, Wesley A.
Seo, Daniel M.
Han, Sang-Don
Allen, Joshua L.
Borodin, Oleg
TI Correlating solution structure to electrolyte properties
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 245th National Meeting of the American-Chemical-Society (ACS)
CY APR 07-11, 2013
CL New Orleans, LA
SP Amer Chem Soc
C1 [Henderson, Wesley A.; Seo, Daniel M.; Han, Sang-Don; Allen, Joshua L.] N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA.
[Borodin, Oleg] Army Res Lab, Electrochem Branch, Sensor & Electron Devices Directorate, Adelphi, MD 20783 USA.
EM whender@ncsu.edu
RI Borodin, Oleg/B-6855-2012
OI Borodin, Oleg/0000-0002-9428-5291
NR 0
TC 0
Z9 0
U1 0
U2 3
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD APR 7
PY 2013
VL 245
MA 652-ENFL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 210RD
UT WOS:000323851305059
ER
PT J
AU Jackson, R
Rockwood, GA
Logue, BA
AF Jackson, Randy
Rockwood, Garry A.
Logue, Brian A.
TI Development of a field sensor for the rapid detection of cyanide
exposure
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 245th National Meeting of the American-Chemical-Society (ACS)
CY APR 07-11, 2013
CL New Orleans, LA
SP Amer Chem Soc
C1 [Jackson, Randy; Logue, Brian A.] S Dakota State Univ, Dept Chem & Biochem, Brookings, SD 57007 USA.
[Rockwood, Garry A.] US Army Med Res Inst Chem Def, Analyt Toxicol Devis, Aberdeen Proving Ground, MD USA.
EM randy.jackson@sdstate.edu
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD APR 7
PY 2013
VL 245
MA 75-ANYL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 210RD
UT WOS:000323851300589
ER
PT J
AU Jacobson, LC
Ren, XM
Molinero, V
AF Jacobson, Liam C.
Ren, Xiaoming
Molinero, Valeria
TI Assessing the effects of crowding, pore size, and interactions on
electro-osmotic drag coefficients
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 245th National Meeting of the American-Chemical-Society (ACS)
CY APR 07-11, 2013
CL New Orleans, LA
SP Amer Chem Soc
C1 [Jacobson, Liam C.; Molinero, Valeria] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA.
[Ren, Xiaoming] US Army Res Lab, RDRL SED C, Adelphi, MD 20783 USA.
EM liam.jacobson@utah.edu
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD APR 7
PY 2013
VL 245
MA 732-ENFL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 210RD
UT WOS:000323851305134
ER
PT J
AU Liu, CH
Pandey, R
Carna, S
Hussain, S
AF Liu, Chinhui
Pandey, Ravindra
Carna, Shashi
Hussain, Saber
TI Modeling of lipid bilayers using first principles method
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 245th National Meeting of the American-Chemical-Society (ACS)
CY APR 07-11, 2013
CL New Orleans, LA
SP Amer Chem Soc
C1 [Liu, Chinhui; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA.
[Carna, Shashi] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Hussain, Saber] US Air Force Res Lab, HEPB, Dayton, OH 45433 USA.
EM chinliu@mtu.edu
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD APR 7
PY 2013
VL 245
MA 74-ENVR
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 210RD
UT WOS:000323851305298
ER
PT J
AU Liu, SC
Sund, CJ
Servinsky, MD
Gerlach, ES
AF Liu, Sanchao
Sund, Christian J.
Servinsky, Matthew D.
Gerlach, Elliot S.
TI H-1 nuclear magnetic resonance studies of arabinose and xylose
metabolism in Clostridium acetobutylicium
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 245th National Meeting of the American-Chemical-Society (ACS)
CY APR 07-11, 2013
CL New Orleans, LA
SP Amer Chem Soc
C1 [Liu, Sanchao; Sund, Christian J.; Servinsky, Matthew D.; Gerlach, Elliot S.] US Army Res Lab, Sensor & Electron Devices Directorate, Adelphi, MD 20783 USA.
EM sanchao.liu.ctr@mail.mil
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD APR 7
PY 2013
VL 245
MA 111-ANYL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 210RD
UT WOS:000323851300326
ER
PT J
AU Mitchell, BL
Rockwood, GA
Logue, BA
AF Mitchell, Brendan L.
Rockwood, Gary A.
Logue, Brian A.
TI Quantification of cyanide metabolite a-ketoglutarate cyanohydrin in
plasma by ultra high-performance liquid chromatography tandem mass
spectrometry
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 245th National Meeting of the American-Chemical-Society (ACS)
CY APR 07-11, 2013
CL New Orleans, LA
SP Amer Chem Soc
C1 [Mitchell, Brendan L.; Logue, Brian A.] S Dakota State Univ, Dept Chem & Biochem, Brookings, SD 57007 USA.
[Rockwood, Gary A.] US Army Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21005 USA.
EM brendan.mitchell@sdstate.edu
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD APR 7
PY 2013
VL 245
MA 17-ANYL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 210RD
UT WOS:000323851300384
ER
PT J
AU Stanzione, JF
Sadler, JM
La Scala, JJ
Wool, RP
AF Stanzione, Joseph F.
Sadler, Joshua M.
La Scala, John J.
Wool, Richard P.
TI Lignin-derived resins for high-performance composite applications
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 245th National Meeting of the American-Chemical-Society (ACS)
CY APR 07-11, 2013
CL New Orleans, LA
SP Amer Chem Soc
C1 [Stanzione, Joseph F.; Wool, Richard P.] Univ Delaware, Dept Chem & Biomol Engn, Newark, DE 19716 USA.
[Sadler, Joshua M.; La Scala, John J.] Army Res Lab, RDRL WMM C, Aberdeen Proving Ground, MD 21005 USA.
EM jfstanz@udel.edu
NR 0
TC 0
Z9 0
U1 0
U2 6
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD APR 7
PY 2013
VL 245
MA 241-CELL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 210RD
UT WOS:000323851301719
ER
PT J
AU Steevens, J
Bates, M
Bednar, A
Chappell, M
Kennedy, A
Moser, R
Poda, A
Weiss, C
AF Steevens, Jeffery
Bates, Matthew
Bednar, Amy
Chappell, Mark
Kennedy, Al
Moser, Robert
Poda, Aimee
Weiss, Charles
TI Life cycle approach for understanding risk of nanoscale materials in
advanced technologies
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 245th National Meeting of the American-Chemical-Society (ACS)
CY APR 07-11, 2013
CL New Orleans, LA
SP Amer Chem Soc
C1 [Steevens, Jeffery; Bates, Matthew; Bednar, Amy; Chappell, Mark; Kennedy, Al; Moser, Robert; Poda, Aimee; Weiss, Charles] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
EM jeffery.a.steevens@us.army.mil
RI Poda, Aimee/K-1905-2012
NR 0
TC 0
Z9 0
U1 0
U2 7
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD APR 7
PY 2013
VL 245
MA 69-ENVR
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 210RD
UT WOS:000323851305293
ER
PT J
AU Tran, DT
Chu, D
AF Tran, Dat T.
Chu, Deryn
TI Desulfurization of JP-8 fuel using Ag/silica based adsorbents at room
temperature
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 245th National Meeting of the American-Chemical-Society (ACS)
CY APR 07-11, 2013
CL New Orleans, LA
SP Amer Chem Soc
C1 [Tran, Dat T.; Chu, Deryn] US Army Res Lab, RDRL SED C, Adelphi, MD 20783 USA.
EM dat.t.tran4.civ@mail.mil
NR 0
TC 0
Z9 0
U1 0
U2 4
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD APR 7
PY 2013
VL 245
MA 809-ENFL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 210RD
UT WOS:000323851305207
ER
PT J
AU Tuinenga, CJ
Luo, HF
Scott, R
Kirkeminde, A
Gong, MG
Totleben, J
Ren, SQ
Chikan, V
AF Tuinenga, Christopher J.
Luo, Hongfu
Scott, Randall
Kirkeminde, Alec
Gong, Maogang
Totleben, Jennifer
Ren, Shenqiang
Chikan, Viktor
TI Indium, tin, and gallium doped CdSe quantum dots for use in hybrid
photovoltaic devices
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 245th National Meeting of the American-Chemical-Society (ACS)
CY APR 07-11, 2013
CL New Orleans, LA
SP Amer Chem Soc
C1 [Tuinenga, Christopher J.] US Army Res Labs, RDRl WMM C, Aberdeen Proving Ground, MD 21005 USA.
[Tuinenga, Christopher J.; Luo, Hongfu; Chikan, Viktor] Kansas State Univ, Dept Chem, Manhattan, KS 66506 USA.
[Scott, Randall; Kirkeminde, Alec; Gong, Maogang; Totleben, Jennifer; Ren, Shenqiang] Univ Kansas, Dept Chem, Lawrence, KS 66045 USA.
EM christopher.tuinenga.ctr@mail.mil
NR 0
TC 0
Z9 0
U1 0
U2 6
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD APR 7
PY 2013
VL 245
MA 80-ENFL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 210RD
UT WOS:000323851304527
ER
PT J
AU Uchimiya, SM
Bannon, DI
AF Uchimiya, Sophie Minori
Bannon, Desmond I.
TI Biochar-attenuated desorption of heavy metals in small arms range soils
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 245th National Meeting of the American-Chemical-Society (ACS)
CY APR 07-11, 2013
CL New Orleans, LA
SP Amer Chem Soc
C1 [Uchimiya, Sophie Minori] USDA ARS, So Reg Res Ctr, New Orleans, LA 70124 USA.
[Bannon, Desmond I.] US Army Publ Hlth Command, Army Inst Publ Hlth, Aberdeen Proving Ground, MD 21010 USA.
EM sophie.uchimiya@ars.usda.gov
NR 0
TC 0
Z9 0
U1 2
U2 5
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD APR 7
PY 2013
VL 245
MA 118-ENVR
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 210RD
UT WOS:000323851305337
ER
PT J
AU Zhong, XL
Amorim, R
Scheicher, R
Karna, S
Pandey, R
AF Zhong, Xiaoliang
Amorim, Rodrigo
Scheicher, Ralph
Karna, Shashi
Pandey, Ravindra
TI Electronic transport in graphene-based heterostructures
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 245th National Meeting of the American-Chemical-Society (ACS)
CY APR 07-11, 2013
CL New Orleans, LA
SP Amer Chem Soc
C1 [Zhong, Xiaoliang; Amorim, Rodrigo; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA.
[Scheicher, Ralph] Uppsala Univ, Dept Phys & Astron, Uppsala, Sweden.
[Karna, Shashi] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM pandey@mtu.edu
NR 0
TC 0
Z9 0
U1 0
U2 9
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD APR 7
PY 2013
VL 245
MA 380-COMP
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 210RD
UT WOS:000323851304387
ER
PT J
AU Izvekov, S
AF Izvekov, Sergei
TI Microscopic derivation of particle-based coarse-grained dynamics
SO JOURNAL OF CHEMICAL PHYSICS
LA English
DT Article
ID NONEQUILIBRIUM STATISTICAL-MECHANICS; MASTER-EQUATIONS; BIOMOLECULAR
SYSTEMS; LANGEVIN-EQUATIONS; OPTIMAL PREDICTION; COUPLED SYSTEMS;
BROWNIAN-MOTION; QUANTUM-THEORY; SIMULATION; MEMORY
AB In this paper we revisit the derivation of equations of motion for coarse-grained (CG) particles from the microscopic Hamiltonian dynamics of the underlying atomistic system in equilibrium. The derivation is based on the projection operator method and time-convolution equation. We demonstrate that due to the energy exchange between CG and intraparticle phase space coordinates in the microscopic system, the choice of projection operator is not unique, leading to different CG equations of motion that have the form of the nonlinear generalized Langevin equation (GLE). We derive the idempotence properties for the projection operators along the system trajectories and show that these properties result in streaming terms of the respective GLEs that are conservative forces and allow the expression of the non-conservative forces explicitly through thermodynamic averages, which can be measured from the microscopic simulations. The difference between GLEs that are presented herein lies in how the non-conservative forces are partitioned into dissipative and projected contributions. We compute the projected force and analyze conditions under which the projected (stochastic) force is orthogonal to (uncorrelated with) the momenta of CG particles, therefore justifying a transition to a framework of stochastic differential equations. We show that a position- and momentum-independent memory function appears only if the projected force is fully decoupled from the past CG positions and momenta, respectively. In the case of non-vanishing correlations between the projected force and the CG coordinates in past times, we derive explicitly the position- and momentum-dependent memory function in a form of projection onto a space spanned by N-order Hermite polynomials. The expressions presented herein can be used to construct a hierarchy of thermodynamically consistent CG models with momentum-dependent memory functions. They can also be used to design computational schemes for obtaining the parameters for GLEs and their variants such as dissipative particle dynamics equations from the microscopic data. We illustrate these applications by presenting the GLE with a memory function that is quadratic in the particle momenta. [http://dx.doi.org/10.1063/1.4795091]
C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Izvekov, S (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM sergiy.izvyekov.civ@mail.mil
FU DoD High Performance Computing Modernization Program Software
Application Institute for Multi-scale Reactive Modeling of Insensitive
Munitions
FX The author wishes to thank Dr. Betsy Rice, Dr. John Brennan, and Dr.
Joshua Moore of the Army Research Laboratory for helpful comments. This
work was supported in part by the DoD High Performance Computing
Modernization Program Software Application Institute for Multi-scale
Reactive Modeling of Insensitive Munitions.
NR 60
TC 12
Z9 12
U1 4
U2 120
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0021-9606
J9 J CHEM PHYS
JI J. Chem. Phys.
PD APR 7
PY 2013
VL 138
IS 13
AR 134106
DI 10.1063/1.4795091
PG 16
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA 128SG
UT WOS:000317788500006
PM 23574207
ER
PT J
AU Foreman, JV
Simmons, JG
Baughman, WE
Liu, J
Everitt, HO
AF Foreman, J. V.
Simmons, J. G., Jr.
Baughman, W. E.
Liu, J.
Everitt, H. O.
TI Localized excitons mediate defect emission in ZnO powders
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
ID BOUND-EXCITON; ZINC-OXIDE; PHOTOLUMINESCENCE; LUMINESCENCE; FILMS;
CATHODOLUMINESCENCE; SPECTROSCOPY; DEPENDENCE; CRYSTALS; PHOSPHOR
AB A series of continuous-wave spectroscopic measurements elucidates the mechanism responsible for the technologically important green emission from deep-level traps in ZnO:Zn powders. Analysis of low-temperature photoluminescence (PL) and PL excitation spectra for bound excitons compared to the temperature-dependent behavior of the green emission reveals a deep correlation between green PL and specific donor-bound excitons. Direct excitation of these bound excitons produces highly efficient green emission from near-surface defects. When normalized by the measured external quantum efficiency, the integrated PL for both excitonic and green emission features grows identically with excitation intensity, confirming the strong connection between green emission and excitons. The implications of these findings are used to circumscribe operational characteristics of doped ZnO-based white light phosphors whose quantum efficiency is almost twice as large when the bound excitons are directly excited. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4798359]
C1 [Foreman, J. V.; Everitt, H. O.] US Army Aviat & Missile Res, Ctr Dev & Engn, Redstone Arsenal, AL 35898 USA.
[Simmons, J. G., Jr.; Liu, J.] Duke Univ, Dept Chem, Durham, NC 27708 USA.
[Baughman, W. E.] Univ Alabama, Dept Elect & Comp Engn, Tuscaloosa, AL 35487 USA.
[Everitt, H. O.] Duke Univ, Dept Phys, Durham, NC 27708 USA.
RP Foreman, JV (reprint author), US Army Aviat & Missile Res, Ctr Dev & Engn, Redstone Arsenal, AL 35898 USA.
EM john.v.foreman.civ@mail.mil
RI Everitt, Henry/L-7118-2013
OI Everitt, Henry/0000-0002-8141-3768
FU RDECOM/AMRDEC In-House Laboratory Independent Research (ILIR); Duke
University; DoD SMART program
FX This work was supported by RDECOM/AMRDEC In-House Laboratory Independent
Research (ILIR) funding and funds from Duke University. J.G.S.
acknowledges support by the DoD SMART program.
NR 27
TC 11
Z9 11
U1 0
U2 52
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0021-8979
J9 J APPL PHYS
JI J. Appl. Phys.
PD APR 7
PY 2013
VL 113
IS 13
AR 133513
DI 10.1063/1.4798359
PG 7
WC Physics, Applied
SC Physics
GA 121IZ
UT WOS:000317238000019
ER
PT J
AU Madrid, PB
Chopra, S
Manger, ID
Gilfillan, L
Keepers, TR
Shurtleff, AC
Green, CE
Iyer, LV
Dilks, HH
Davey, RA
Kolokoltsov, AA
Carrion, R
Patterson, JL
Bavari, S
Panchal, RG
Warren, TK
Wells, JB
Moos, WH
Burke, RL
Tanga, MJ
AF Madrid, Peter B.
Chopra, Sidharth
Manger, Ian D.
Gilfillan, Lynne
Keepers, Tiffany R.
Shurtleff, Amy C.
Green, Carol E.
Iyer, Lalitha V.
Dilks, Holli Hutcheson
Davey, Robert A.
Kolokoltsov, Andrey A.
Carrion, Ricardo, Jr.
Patterson, Jean L.
Bavari, Sina
Panchal, Rekha G.
Warren, Travis K.
Wells, Jay B.
Moos, Walter H.
Burke, RaeLyn L.
Tanga, Mary J.
TI A Systematic Screen of FDA-Approved Drugs for Inhibitors of Biological
Threat Agents
SO PLOS ONE
LA English
DT Article
ID VIRAL-INFECTIONS; VIRUS-INFECTION; EBOLA-VIRUS; OLD DRUGS; IN-VITRO;
Q-FEVER; CHLOROQUINE; 4-AMINOQUINOLINE; CHIKUNGUNYA; HIV
AB Background: The rapid development of effective medical countermeasures against potential biological threat agents is vital. Repurposing existing drugs that may have unanticipated activities as potential countermeasures is one way to meet this important goal, since currently approved drugs already have well-established safety and pharmacokinetic profiles in patients, as well as manufacturing and distribution networks. Therefore, approved drugs could rapidly be made available for a new indication in an emergency.
Methodology/Principal Findings: A large systematic effort to determine whether existing drugs can be used against high containment bacterial and viral pathogens is described. We assembled and screened 1012 FDA-approved drugs for off-label broad-spectrum efficacy against Bacillus anthracis; Francisella tularensis; Coxiella burnetii; and Ebola, Marburg, and Lassa fever viruses using in vitro cell culture assays. We found a variety of hits against two or more of these biological threat pathogens, which were validated in secondary assays. As expected, antibiotic compounds were highly active against bacterial agents, but we did not identify any non-antibiotic compounds with broad-spectrum antibacterial activity. Lomefloxacin and erythromycin were found to be the most potent compounds in vivo protecting mice against Bacillus anthracis challenge. While multiple virus-specific inhibitors were identified, the most noteworthy antiviral compound identified was chloroquine, which disrupted entry and replication of two or more viruses in vitro and protected mice against Ebola virus challenge in vivo.
Conclusions/Significance: The feasibility of repurposing existing drugs to face novel threats is demonstrated and this represents the first effort to apply this approach to high containment bacteria and viruses.
C1 [Madrid, Peter B.; Chopra, Sidharth; Manger, Ian D.; Gilfillan, Lynne; Keepers, Tiffany R.; Shurtleff, Amy C.; Green, Carol E.; Iyer, Lalitha V.; Dilks, Holli Hutcheson; Moos, Walter H.; Burke, RaeLyn L.; Tanga, Mary J.] SRI Int, Ctr Infect Dis & Biodefense Res, Menlo Pk, CA 94025 USA.
[Davey, Robert A.; Kolokoltsov, Andrey A.] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA.
[Carrion, Ricardo, Jr.; Patterson, Jean L.] Texas Biomed Res Inst, San Antonio, TX USA.
[Panchal, Rekha G.; Warren, Travis K.; Wells, Jay B.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
RP Madrid, PB (reprint author), SRI Int, Ctr Infect Dis & Biodefense Res, 333 Ravenswood Ave, Menlo Pk, CA 94025 USA.
EM peter.madrid@sri.com
OI Chopra, Sidharth/0000-0001-8823-6074
FU Defense Threat Reduction Agency [HDTRA1-07-C-0083]; SRI International
FX This work was supported by the Defense Threat Reduction Agency contract
HDTRA1-07-C-0083 and internal grants of SRI International. The views
expressed in this publication are those of the authors and not
necessarily those of the funding organization. The funders had no role
in study design, data collection and analysis, decision to publish, or
preparation of the manuscript.
NR 48
TC 57
Z9 61
U1 5
U2 32
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 5
PY 2013
VL 8
IS 4
AR e60579
DI 10.1371/journal.pone.0060579
PG 14
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 146RZ
UT WOS:000319109800067
PM 23577127
ER
PT J
AU Apps, R
Qi, Y
Carlson, JM
Chen, HY
Gao, XJ
Thomas, R
Yuki, Y
Del Prete, GQ
Goulder, P
Brumme, ZL
Brumme, CJ
John, M
Mallal, S
Nelson, G
Bosch, R
Heckerman, D
Stein, JL
Soderberg, KA
Moody, MA
Denny, TN
Zeng, X
Fang, JY
Moffett, A
Lifson, JD
Goedert, JJ
Buchbinder, S
Kirk, GD
Fellay, J
McLaren, P
Deeks, SG
Pereyra, F
Walker, B
Michael, NL
Weintrob, A
Wolinsky, S
Liao, W
Carrington, M
AF Apps, Richard
Qi, Ying
Carlson, Jonathan M.
Chen, Haoyan
Gao, Xiaojiang
Thomas, Rasmi
Yuki, Yuko
Del Prete, Greg Q.
Goulder, Philip
Brumme, Zabrina L.
Brumme, Chanson J.
John, Mina
Mallal, Simon
Nelson, George
Bosch, Ronald
Heckerman, David
Stein, Judy L.
Soderberg, Kelly A.
Moody, M. Anthony
Denny, Thomas N.
Zeng, Xue
Fang, Jingyuan
Moffett, Ashley
Lifson, Jeffrey D.
Goedert, James J.
Buchbinder, Susan
Kirk, Gregory D.
Fellay, Jacques
McLaren, Paul
Deeks, Steven G.
Pereyra, Florencia
Walker, Bruce
Michael, Nelson L.
Weintrob, Amy
Wolinsky, Steven
Liao, Wilson
Carrington, Mary
TI Influence of HLA-C Expression Level on HIV Control
SO SCIENCE
LA English
DT Article
ID INFLAMMATORY-BOWEL-DISEASE; T-CELL RESPONSES; DETERMINANTS;
ASSOCIATIONS; METAANALYSIS; ALLELES; SYNAPSE; ESCAPE; NUMBER
AB A variant upstream of human leukocyte antigen C (HLA-C) shows the most significant genome-wide effect on HIV control in European Americans and is also associated with the level of HLA-C expression. We characterized the differential cell surface expression levels of all common HLA-C allotypes and tested directly for effects of HLA-C expression on outcomes of HIV infection in 5243 individuals. Increasing HLA-C expression was associated with protection against multiple outcomes independently of individual HLA allelic effects in both African and European Americans, regardless of their distinct HLA-C frequencies and linkage relationships with HLA-B and HLA-A. Higher HLA-C expression was correlated with increased likelihood of cytotoxic T lymphocyte responses and frequency of viral escape mutation. In contrast, high HLA-C expression had a deleterious effect in Crohn's disease, suggesting a broader influence of HLA expression levels in human disease.
C1 [Apps, Richard; Qi, Ying; Gao, Xiaojiang; Thomas, Rasmi; Yuki, Yuko; Carrington, Mary] SAIC Frederick Inc, Frederick Natl Lab Canc Res, Expt Immunol Lab, Canc & Inflammat Program, Frederick, MD 21702 USA.
[Apps, Richard; Qi, Ying; Gao, Xiaojiang; Yuki, Yuko; Goulder, Philip; Pereyra, Florencia; Walker, Bruce; Carrington, Mary] Massachusetts Gen Hosp, MIT, Ragon Inst, Boston, MA 02114 USA.
[Apps, Richard; Qi, Ying; Gao, Xiaojiang; Yuki, Yuko; Goulder, Philip; Pereyra, Florencia; Walker, Bruce; Carrington, Mary] Harvard Univ, Boston, MA 02114 USA.
[Carlson, Jonathan M.; Heckerman, David; Zeng, Xue] Microsoft Res, ESci Grp, Los Angeles, CA 90024 USA.
[Chen, Haoyan; Fang, Jingyuan; Liao, Wilson] Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94115 USA.
[Chen, Haoyan; Lifson, Jeffrey D.] Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Digest Dis, Dept Gastroenterol,Ren Ji Hosp, Shanghai 200001, Peoples R China.
[Del Prete, Greg Q.] SAIC Frederick Inc, Frederick Natl Lab Canc Res, AIDS & Canc Virus Program, Frederick, MD 21702 USA.
[Goulder, Philip] Univ KwaZulu Natal, Nelson R Mandela Sch Med, Doris Duke Med Res Inst, HIV Pathogenesis Programme, Durban, South Africa.
[Goulder, Philip] Univ Oxford, Dept Paediat, Oxford OX1 3SY, England.
[Brumme, Zabrina L.; Brumme, Chanson J.] British Columbia Ctr Excellence HIV AIDS, Vancouver, BC V6Z 1Y6, Canada.
[Brumme, Zabrina L.] Simon Fraser Univ, Fac Hlth Sci, Burnaby, BC V5A 1S6, Canada.
[John, Mina; Mallal, Simon] Murdoch Univ, Inst Immunol & Infect Dis, Murdoch, WA 6150, Australia.
[Nelson, George] SAIC Frederick Inc, Frederick Natl Lab Canc Res, Ctr Canc Res Genet Core, Basic Res Program, Frederick, MD 21702 USA.
[Bosch, Ronald] Harvard Univ, Sch Publ Hlth, Ctr Biostat AIDS Res, Boston, MA 02115 USA.
[Stein, Judy L.; Soderberg, Kelly A.; Moody, M. Anthony; Denny, Thomas N.] Duke Univ, Duke Human Vaccine Inst, Durham, NC 27710 USA.
[Zeng, Xue] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Dermatol, Beijing 100053, Peoples R China.
[Moffett, Ashley] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England.
[Goedert, James J.] NCI, Div Canc Epidemiol & Genet, Infect & Immunoepidemiol Branch, Bethesda, MD 20892 USA.
[Buchbinder, Susan] San Francisco Dept Publ Hlth, San Francisco, CA 94102 USA.
[Kirk, Gregory D.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA.
[Fellay, Jacques; McLaren, Paul] Univ Lausanne Hosp, Inst Microbiol, CH-1015 Lausanne, Switzerland.
[Fellay, Jacques; McLaren, Paul] Ecole Polytech Fed Lausanne, Sch Life Sci, CH-1015 Lausanne, Switzerland.
[Deeks, Steven G.] Univ Calif San Francisco, Dept Med, San Francisco, CA 94105 USA.
[Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
[Weintrob, Amy] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20817 USA.
[Wolinsky, Steven] Northwestern Univ, Feinberg Sch Med, Div Infect Dis, Chicago, IL 60611 USA.
RP Carrington, M (reprint author), SAIC Frederick Inc, Frederick Natl Lab Canc Res, Expt Immunol Lab, Canc & Inflammat Program, Frederick, MD 21702 USA.
EM carringm@mail.nih.gov
RI Del Prete, Gregory/C-2030-2012; Moffett, Ashley/J-9754-2013; SHCS, int.
coll. A/G-4083-2011; Fellay, Jacques/A-6681-2009; SHCS, all/G-4072-2011;
OI Fellay, Jacques/0000-0002-8240-939X; Denny, Thomas/0000-0002-7364-8276;
Wolinsky, Steven/0000-0002-9625-6697; Moody, Tony/0000-0002-3890-5855;
Brumme, Chanson/0000-0003-2722-5288
FU National Institutes of Health (NIH) [HHSN261200800001E, N02-CP-55504,
RO1-AI046995, R01-DA04334, R01-DA12568, R01-AI060460]; Bill & Melinda
Gates Foundation [38599]; Mark and Lisa Schwartz Foundation; Wellcome
Trust; NIH National Institute of Allergy and Infectious Diseases (NIAID)
Center for HIV/AIDS Vaccine Immunology [U01-AI-067854]; Australian
National Health and Medical Research Council [384702]; National
Institutes of Health [K08AR057763, R01-DA-04334, R01-DA-12568]; Creative
and Novel Ideas in HIV Research Program [P30 AI027767-24]; Swiss
National Science Foundation [33CSC0-108787]; NIAID; National Cancer
Institute; National Heart, Lung, and Blood Institute [UO1-AI-35042,
5-MO1-RR-00722 (GCRC), UO1-AI-35043, UO1-AI-37984, UO1-AI-35039,
UO1-AI-35040, UO1-AI-37613, UO1-AI-35041]; [RO1 AI087145];
[K24AI069994]; [P30 AI027763]; [UL1 RR024131]; [P30 MH62246]; [R24
AI067039]
FX This study makes use of data generated by the Wellcome Trust Case
Control Consortium (WTCCC); a full list of investigators who contributed
to the generation of this data is available at www.wtccc.org.uk. The
data reported in this paper are tabulated in the main paper and
supplementary materials. Data and materials will be shared subject to
institutional review board (IRB) provisions regarding patient privacy.
Please contact the corresponding author. Those interested in obtaining
Center for HIV/AIDS Vaccine Immunology (CHAVI) samples used in this
study should contact M. C. and M. A. M. A Simple Letter Agreement for
the Transfer of Materials will be executed between the institutions
involved, and an IRB approval/exemption should be obtained by the
recipient institution when appropriate. Clinical specimens from the
Multicenter AIDS Cohort Study (MACS) are subject to the terms and
conditions of the MACS Master Material Transfer Agreement for Non-Profit
Institutions. The project has been funded in part with federal funds
from the National Institutes of Health (NIH) under contracts
HHSN261200800001E, N02-CP-55504, RO1-AI046995, R01-DA04334, R01-DA12568,
and R01-AI060460. The content of this publication does not necessarily
reflect the views or policies of the Department of Health and Human
Services or the Department of Defense, nor does mention of trade names,
commercial products, or organizations imply endorsement by the U. S.
Government. This research was supported in part by grants from the Bill
& Melinda Gates Foundation as part of the Collaboration for AIDS Vaccine
Discovery and grant ID38599, the Mark and Lisa Schwartz Foundation, the
Wellcome Trust, the NIH National Institute of Allergy and Infectious
Diseases (NIAID) Center for HIV/AIDS Vaccine Immunology (U01-AI-067854),
and the Australian National Health and Medical Research Council (Program
Grant 384702). Further funding was from the National Institutes of
Health grant K08AR057763 and the Creative and Novel Ideas in HIV
Research Program through a supplement to the University of Alabama at
the Birmingham Center For AIDS Research funding (P30 AI027767-24), made
possible by collaborative efforts of the Office of AIDS Research, NIAID,
and the International AIDS Society. We thank M. Trubey and A. Lara for
cytometry assistance and all the patients and investigators contributing
to samples studied in the WTCCC, CHAVI, Multicenter Hemophilia Cohort
Study, San Francisco City Clinic Cohort, Massachusetts General Hospital
Controller Cohort, United States Military HIV Natural History Study, DC
Gay Cohort Study, British Columbia HOMER cohort, Western Australian HIV
Cohort Study, US AIDS Clinical Trials Group, Durban, AIDS Linked to
Intravenous Experience (supported by National Institutes of Health
grants R01-DA-04334 and R01-DA-12568), Swiss HIV Cohort Study (supported
by the Swiss National Science Foundation grant number 33CSC0-108787),
Study on the Consequences of Protease Inhibitor Era (supported by grants
RO1 AI087145, K24AI069994, P30 AI027763, UL1 RR024131, P30 MH62246, and
R24 AI067039), and MACS cohorts (funded by NIAID, with supplemental
funding from the National Cancer Institute and the National Heart, Lung,
and Blood Institute [grants UO1-AI-35042, 5-MO1-RR-00722 (GCRC),
UO1-AI-35043, UO1-AI-37984, UO1-AI-35039, UO1-AI-35040, UO1-AI-37613,
and UO1-AI-35041].
NR 25
TC 114
Z9 115
U1 2
U2 51
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 0036-8075
J9 SCIENCE
JI Science
PD APR 5
PY 2013
VL 340
IS 6128
BP 87
EP 91
DI 10.1126/science.1232685
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 118XS
UT WOS:000317061100052
PM 23559252
ER
PT J
AU Brudner, M
Karpel, M
Lear, C
Chen, L
Yantosca, LM
Scully, C
Sarraju, A
Sokolovska, A
Zariffard, MR
Eisen, DP
Mungall, BA
Kotton, DN
Omari, A
Huang, IC
Farzan, M
Takahashi, K
Stuart, L
Stahl, GL
Ezekowitz, AB
Spear, GT
Olinger, GG
Schmidt, EV
Michelow, IC
AF Brudner, Matthew
Karpel, Marshall
Lear, Calli
Chen, Li
Yantosca, L. Michael
Scully, Corinne
Sarraju, Ashish
Sokolovska, Anna
Zariffard, M. Reza
Eisen, Damon P.
Mungall, Bruce A.
Kotton, Darrell N.
Omari, Amel
Huang, I-Chueh
Farzan, Michael
Takahashi, Kazue
Stuart, Lynda
Stahl, Gregory L.
Ezekowitz, Alan B.
Spear, Gregory T.
Olinger, Gene G.
Schmidt, Emmett V.
Michelow, Ian C.
TI Lectin-Dependent Enhancement of Ebola Virus Infection via Soluble and
Transmembrane C-type Lectin Receptors
SO PLOS ONE
LA English
DT Article
ID MANNOSE-BINDING LECTIN; RP-C4-CYP21-TNX RCCX MODULES;
POLYMERASE-CHAIN-REACTION; COPY-NUMBER VARIATIONS; WEST NILE VIRUS;
ENVELOPE GLYCOPROTEINS; INFLAMMATORY RESPONSE; SURFACE GLYCOPROTEIN;
FALCIPARUM-MALARIA; SERINE PROTEASE-2
AB Mannose-binding lectin (MBL) is a key soluble effector of the innate immune system that recognizes pathogen-specific surface glycans. Surprisingly, low-producing MBL genetic variants that may predispose children and immunocompromised individuals to infectious diseases are more common than would be expected in human populations. Since certain immune defense molecules, such as immunoglobulins, can be exploited by invasive pathogens, we hypothesized that MBL might also enhance infections in some circumstances. Consequently, the low and intermediate MBL levels commonly found in human populations might be the result of balancing selection. Using model infection systems with pseudotyped and authentic glycosylated viruses, we demonstrated that MBL indeed enhances infection of Ebola, Hendra, Nipah and West Nile viruses in low complement conditions. Mechanistic studies with Ebola virus (EBOV) glycoprotein pseudotyped lentiviruses confirmed that MBL binds to N-linked glycan epitopes on viral surfaces in a specific manner via the MBL carbohydrate recognition domain, which is necessary for enhanced infection. MBL mediates lipid-raft-dependent macropinocytosis of EBOV via a pathway that appears to require less actin or early endosomal processing compared with the filovirus canonical endocytic pathway. Using a validated RNA interference screen, we identified C1QBP (gC1qR) as a candidate surface receptor that mediates MBL-dependent enhancement of EBOV infection. We also identified dectin-2 (CLEC6A) as a potentially novel candidate attachment factor for EBOV. Our findings support the concept of an innate immune haplotype that represents critical interactions between MBL and complement component C4 genes and that may modify susceptibility or resistance to certain glycosylated pathogens. Therefore, higher levels of native or exogenous MBL could be deleterious in the setting of relative hypocomplementemia which can occur genetically or because of immunodepletion during active infections. Our findings confirm our hypothesis that the pressure of infectious diseases may have contributed in part to evolutionary selection of MBL mutant haplotypes.
C1 [Brudner, Matthew; Karpel, Marshall; Chen, Li; Yantosca, L. Michael; Sarraju, Ashish; Sokolovska, Anna; Takahashi, Kazue; Stuart, Lynda; Ezekowitz, Alan B.; Schmidt, Emmett V.; Michelow, Ian C.] Massachusetts Gen Hosp, Dept Pediat, Programs Dev Immunol, Boston, MA 02114 USA.
[Lear, Calli; Scully, Corinne; Olinger, Gene G.] USA, Div Virol, Med Res Inst Infect Dis, Frederick, MD USA.
[Zariffard, M. Reza] Rush Univ, Dept Immunol & Microbiol, Med Ctr, Chicago, IL 60612 USA.
[Eisen, Damon P.] Royal Melbourne Hosp, Victorian Infect Dis Serv, Parkville, Vic 3050, Australia.
[Mungall, Bruce A.] Commonwealth Sci & Ind Res Org CSIRO Livestock In, Australian Anim Hlth Lab, Geelong, Vic, Australia.
[Kotton, Darrell N.; Omari, Amel] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA.
[Huang, I-Chueh; Farzan, Michael] New England Reg Primate Res Ctr, Southborough, MA 01772 USA.
[Stahl, Gregory L.] Brigham & Womens Hosp, CETRI, Boston, MA 02115 USA.
[Huang, I-Chueh; Farzan, Michael; Takahashi, Kazue; Stuart, Lynda; Stahl, Gregory L.; Schmidt, Emmett V.; Michelow, Ian C.] Harvard Univ, Sch Med, Boston, MA USA.
RP Schmidt, EV (reprint author), Massachusetts Gen Hosp, Dept Pediat, Programs Dev Immunol, Boston, MA 02114 USA.
EM eschmidt@partners.org; ian_michelow@brown.edu
OI Olinger, Gene/0000-0001-7338-0292; Kotton, Darrell/0000-0002-9604-8476
FU National Institutes of Health [U01 AI070330]; United States Department
of Defense, Defense Threat Reduction Agency Biological Therapeutics
Program [4.10006, 4.10007]
FX This work was supported by National Institutes of Health Grant U01
AI070330 (to EVS) and by United States Department of Defense, Defense
Threat Reduction Agency Biological Therapeutics Program Grants 4.10006
and 4.10007 (to GGO). The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
NR 102
TC 17
Z9 17
U1 1
U2 22
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 2
PY 2013
VL 8
IS 4
AR e60838
DI 10.1371/journal.pone.0060838
PG 19
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 127RY
UT WOS:000317717300151
PM 23573288
ER
PT J
AU Michael, NL
AF Michael, Nelson L.
TI Advances in Preventive HIV Vaccine Development
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Meeting Abstract
CT 14th Annual International Meeting of the Institute-of-Human-Virology
CY OCT 14-17, 2012
CL Univ Maryland Sch Med, Baltimore, MD
SP Inst Human Virol
HO Univ Maryland Sch Med
C1 [Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1525-4135
EI 1077-9450
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD APR
PY 2013
VL 62
SU 1
BP 51
EP 51
PG 1
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 300IQ
UT WOS:000330458000042
ER
PT J
AU Harrison, OB
Claus, H
Jiang, Y
Bennett, JS
Bratcher, HB
Jolley, KA
Corton, C
Care, R
Poolman, JT
Zollinger, WD
Frasch, CE
Stephens, DS
Feavers, I
Frosch, M
Parkhill, J
Vogel, U
Quail, MA
Bentley, SD
Maiden, MCJ
AF Harrison, Odile B.
Claus, Heike
Jiang, Ying
Bennett, Julia S.
Bratcher, Holly B.
Jolley, Keith A.
Corton, Craig
Care, Rory
Poolman, Jan T.
Zollinger, Wendell D.
Frasch, Carl E.
Stephens, David S.
Feavers, Ian
Frosch, Matthias
Parkhill, Julian
Vogel, Ulrich
Quail, Michael A.
Bentley, Stephen D.
Maiden, Martin C. J.
TI Description and Nomenclature of Neisseria meningitidis Capsule Locus
SO EMERGING INFECTIOUS DISEASES
LA English
DT Article
ID NUCLEAR-MAGNETIC-RESONANCE; MENINGOCOCCAL POLYSACCHARIDES; STRUCTURAL
DETERMINATION; CHEMICAL PROPERTIES; SEROGROUP-Y; GROUP-B; ANTIGEN;
BIOSYNTHESIS; GENETICS; ELUCIDATION
AB Pathogenic Neisseria meningitidis isolates contain a polysaccharide capsule that is the main virulence determinant for this bacterium. Thirteen capsular polysaccharides have been described, and nuclear magnetic resonance spectroscopy has enabled determination of the structure of capsular polysaccharides responsible for serogroup specificity. Molecular mechanisms involved in N. meningitidis capsule biosynthesis have also been identified, and genes involved in this process and in cell surface translocation are clustered at a single chromosomal locus termed cps. The use of multiple names for some of the genes involved in capsule synthesis, combined with the need for rapid diagnosis of serogroups commonly associated with invasive meningococcal disease, prompted a requirement for a consistent approach to the nomenclature of capsule genes. In this report, a comprehensive description of all N. meningitidis serogroups is provided, along with a proposed nomenclature, which was presented at the 2012 XVIIIth International Pathogenic Neisseria Conference.
C1 [Harrison, Odile B.] Univ Oxford, Dept Zool, Oxford OX1 3PS, England.
[Bennett, Julia S.; Bratcher, Holly B.; Jolley, Keith A.; Maiden, Martin C. J.] Univ Oxford, Oxford OX1 3PS, England.
[Claus, Heike; Frosch, Matthias; Vogel, Ulrich] Univ Wurzburg, D-97070 Wurzburg, Germany.
[Jiang, Ying; Corton, Craig; Parkhill, Julian; Quail, Michael A.; Bentley, Stephen D.] Sanger Inst, Cambridge, England.
[Care, Rory; Feavers, Ian] Natl Inst Biol Stand & Controls, Potters Bar, Herts, England.
[Poolman, Jan T.] Crucell, Leiden, Netherlands.
[Zollinger, Wendell D.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Frasch, Carl E.] Frasch Biol Consulting, Martinsburg, WV USA.
[Stephens, David S.] Emory Univ, Atlanta, GA 30322 USA.
RP Harrison, OB (reprint author), Univ Oxford, Dept Zool, S Parks Rd, Oxford OX1 3PS, England.
EM odile.harrison@zoo.ox.ac.uk
RI Frosch, Matthias/H-2411-2013; Parkhill, Julian/G-4703-2011;
OI Parkhill, Julian/0000-0002-7069-5958; Maiden,
Martin/0000-0001-6321-5138; Jolley, Keith/0000-0002-0751-0287
FU Wellcome Trust [087622]
NR 40
TC 63
Z9 65
U1 0
U2 9
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
EI 1080-6059
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD APR
PY 2013
VL 19
IS 4
BP 566
EP 573
DI 10.3201/eid1904.111799
PG 8
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 268LV
UT WOS:000328173100006
PM 23628376
ER
PT J
AU Fildes, JM
Meyers, SJ
Mulligan, CP
Kilaparti, R
AF Fildes, J. M.
Meyers, S. J.
Mulligan, C. P.
Kilaparti, R.
TI Evaluation of the wear and abrasion resistance of hard coatings by
ball-on-three-disk test methods-A case study
SO WEAR
LA English
DT Article
DE Ball-on-three-disk; Three-body abrasion; Wear testing
ID FILMS; TIN
AB Engineered surfaces can provide superior resistance to abrasive and adhesive wear. There are many types of hard coatings readily available including diamond-like-carbon (DLC) coatings, nitrides, carbides, oxides, etc., and due to the many processing alternatives including alloying element, thickness, deposition technique, etc. each of these types contains a virtually endless number of choices. Fundamental materials properties such as hardness and toughness are often not adequate to reflect how a particular coating will perform, and some of these properties, toughness for example, can be hard to measure and are usually not available. In contrast, bench-scale measurements of friction and wear can provide reliable and meaningful data. However, many of these techniques are expensive and time-consuming and determining the best coating to meet the requirements of a specific application amongst this endless variety of materials can be cost-prohibitive. In this case, ball-on-three-disk (BOTD) test methods are used to provide a rapid, cost-effective, and accurate measure of the wear and abrasion resistance of representative samples of many of the types of coatings being designed with modern techniques. This work provides a case study of steel coated with seven types of nitrides, novel Cr and Ni plated coatings, as well as baseline uncoated and manganese phosphate coated steel samples. The data illustrates the value of the BOTD test method as a bench-scale tribological test as well as significant insight to how subtle design features and changes in the testing conditions of coatings can lead to significant differences in performance. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Fildes, J. M.; Meyers, S. J.] Inst Tribol & Coatings, Sugar Grove, IL 60554 USA.
[Mulligan, C. P.] Armament Res Dev & Engn Ctr, US Army Benet Labs, Watervliet, NY 12189 USA.
[Kilaparti, R.] No Illinois Univ, Coll Engn & Engn Technol, De Kalb, IL 60115 USA.
RP Fildes, JM (reprint author), Inst Tribol & Coatings, 1019 Air Pk Dr, Sugar Grove, IL 60554 USA.
EM jfildes@tribologyinstitute.org
NR 13
TC 4
Z9 4
U1 1
U2 6
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0043-1648
J9 WEAR
JI Wear
PD APR-MAY
PY 2013
VL 302
IS 1-2
SI SI
BP 1040
EP 1049
DI 10.1016/j.wear.2012.11.018
PG 10
WC Engineering, Mechanical; Materials Science, Multidisciplinary
SC Engineering; Materials Science
GA 195DP
UT WOS:000322682800024
ER
PT J
AU Resio, DT
Irish, JL
Westerink, JJ
Powell, NJ
AF Resio, Donald T.
Irish, Jennifer L.
Westerink, Joannes J.
Powell, Nancy J.
TI The effect of uncertainty on estimates of hurricane surge hazards
SO NATURAL HAZARDS
LA English
DT Article
DE Storm surges; Hurricanes; Hazards; Risk; Uncertainty
ID RESPONSE FUNCTION-APPROACH; WIND; INTENSITY; MODEL
AB It is shown here that uncertainty can significantly affect estimated surge levels over a wide range of annual exceedance probabilities (AEPs). For AEPs in the range of 1 x 10(-2)-5 x 10(-2) in the New Orleans area, estimated surge values with and without consideration of uncertainty differ by about 0.5-1.0 m. Similarly, suppression of natural variability, such as using a single value for Mississippi River discharge in surge simulations, rather than allowing the discharge to vary probabilistically, is shown to produce deviations up to 1 m for the 1 x 10(-2) AEP in locations within the mainline river levees in this area. It is also shown that uncertainty can play a critical role in the analysis of very low probability events in the AEP range 1 x 10(-4)-1 x 10(-6). Such events are typically used in designs of structures with major societal impacts. It is shown here that, for this range of AEPs along the west coast of Florida, the neglect of uncertainty can under-predict design surge levels by about 20 % compared to estimated surge levels that include uncertainty.
C1 [Resio, Donald T.] Univ N Florida, Jacksonville, FL 32224 USA.
[Irish, Jennifer L.] Virginia Tech, Blacksburg, VA USA.
[Westerink, Joannes J.] Univ Notre Dame, Notre Dame, IN 46556 USA.
[Powell, Nancy J.] US Army Corps Engineers Dist, New Orleans, LA USA.
RP Resio, DT (reprint author), Univ N Florida, Jacksonville, FL 32224 USA.
EM don.resio@unf.edu
OI Irish, Jennifer/0000-0002-2429-5953
NR 16
TC 7
Z9 7
U1 1
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0921-030X
J9 NAT HAZARDS
JI Nat. Hazards
PD APR
PY 2013
VL 66
IS 3
BP 1443
EP 1459
DI 10.1007/s11069-012-0315-1
PG 17
WC Geosciences, Multidisciplinary; Meteorology & Atmospheric Sciences;
Water Resources
SC Geology; Meteorology & Atmospheric Sciences; Water Resources
GA 135UC
UT WOS:000318313000010
ER
PT J
AU Samy, RP
Gopalakrishnakone, P
Satyanarayanajois, SD
Stiles, BG
Chow, VTK
AF Samy, Ramar Perumal
Gopalakrishnakone, Ponnampalam
Satyanarayanajois, Seetharama D.
Stiles, Bradley G.
Chow, Vincent T. K.
TI Snake Venom Proteins and Peptides as Novel Antibiotics Against Microbial
Infections
SO CURRENT PROTEOMICS
LA English
DT Article
DE Antibiotics; antimicrobial peptides; L-amino acid oxidase; microbial
infections; phospholipase A(2); snake cathelicidin
ID AMINO-ACID OXIDASE; LYS49 PHOSPHOLIPASE A(2); MEMBRANE-DAMAGING
ACTIVITIES; BRADYKININ-POTENTIATING PEPTIDES; CATIONIC ANTIMICROBIAL
PEPTIDES; AMERICAN RATTLESNAKE VENOM; BOTHROPS-JARARACUSSU VENOM;
DURISSUS-TERRIFICUS VENOM; MANNOSE-BINDING LECTIN; HOST-DEFENSE PEPTIDES
AB Animals produce a large variety of antimicrobial peptides that play an important role in natural innate immunity and controlling microbial infections. Snakes are classified into the phylum Chordata and class Reptilia, within the animal kingdom. Snake venoms are extensive mixtures that contain a large number of biologically active proteins/peptides that represent a promising source of potential therapeutics for both humans and animals. These components are extensively studied for a wide range of pharmacological properties; however, it is quite exceptional that very little is relatively known about antimicrobial activity associated with venoms to date. In this review, we emphasize the available literature linked to antimicrobial activity of venom proteins such as L-amino acid oxidase (LAAO), phospholipase A(2) (PLA(2)), peptides and snake cathelicidin. We propose a model for antimicrobial action in comparison with existing mechanisms. Structure and function of snake venom proteins/peptides in relation to antimicrobial activity and its involvement in molecular pharmacology thoroughly discussed. Nevertheless, snake venom enzymes and various classes of peptides have unique pharmacological properties, enhanced properties of antimicrobial effects against various bacterial infections, as well as varying levels of toxicity on eukaryotic and prokaryotic cells. In conclusions, these peptide-based molecules may ultimately be used as alternative drugs to replace chemical antibiotics that increasingly become less useful due to highly-evolved resistance mechanisms employed by various microbial pathogens.
C1 [Samy, Ramar Perumal; Chow, Vincent T. K.] Natl Univ Singapore, Natl Univ Hlth Syst, Dept Microbiol, Singapore 117597, Singapore.
[Samy, Ramar Perumal; Gopalakrishnakone, Ponnampalam] Natl Univ Singapore, Natl Univ Hlth Syst, Dept Anat, Venom & Toxin Res Program, Singapore 117597, Singapore.
[Satyanarayanajois, Seetharama D.] Univ Louisiana, Coll Pharm, Dept Basic Pharmaceut Sci, Monroe, LA 71291 USA.
[Stiles, Bradley G.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Stiles, Bradley G.] Wilson Coll, Dept Biol, Chambersburg, PA 17201 USA.
RP Samy, RP (reprint author), Natl Univ Singapore, Natl Univ Hlth Syst, Dept Microbiol, MD 4,5 Sci Dr 2, Singapore 117597, Singapore.
EM micrama@nus.edu.sg
FU Proof Of Concept (POC), Economic Development Board (EDB) grant WBS,
Singapore [R - 181 000 110 141]
FX This work was supported by Proof Of Concept (POC), Economic Development
Board (EDB) grant WBS No: R - 181 000 110 141, Singapore.
NR 171
TC 4
Z9 4
U1 2
U2 20
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
EMIRATES
SN 1570-1646
EI 1875-6247
J9 CURR PROTEOMICS
JI Curr. Proteomics
PD APR
PY 2013
VL 10
IS 1
BP 10
EP 28
PG 19
WC Biochemical Research Methods; Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 171IH
UT WOS:000320918600003
ER
PT J
AU Russell, D
Bettoli, PW
AF Russell, Drew
Bettoli, Phillip W.
TI Population Attributes of Lake Trout in Tennessee Reservoirs
SO SOUTHEASTERN NATURALIST
LA English
DT Article
ID SALVELINUS-NAMAYCUSH; THERMAL HABITAT; GROWTH; FISH; SUPERIOR; MODEL;
ECOLOGY; ONTARIO; BIOLOGY; CHAR
AB We sampled stocked Salvelinus namaycush (Lake Trout) in Watauga Lake and South Holston Lake, TN using experimental gill nets in 2009-2010 to describe their growth, longevity, and condition. Annuli in sagittal otoliths formed once a year in early spring in both reservoirs. South Holston Lake (n = 99 Lake Trout) has been stocked since 2006, and the oldest fish was age 4. Watauga Lake has been stocked since the mid-1980s, and we collected 158 Lake Trout up to age 20. Annual mortality for age-3 and older fish in Watauga Lake was 24%. When compared to Lake Trout in northern lakes, Tennessee Lake Trout exhibited average to above-average growth and longevity. Condition of Lake Trout in both reservoirs varied seasonally and tended to be lowest in fall, but rebounded in winter and spring. Lake Trout in both reservoirs appeared to be spatially segregated from pelagic prey fishes during summer stratification, but growth rates and body condition were high enough to suggest that neither system was being overstocked.
C1 [Russell, Drew; Bettoli, Phillip W.] Tennessee Technol Univ, Tennessee Cooperat Fishery Res Unit, Cookeville, TN 38505 USA.
RP Russell, D (reprint author), USA, Corps Engineers, 600 Dr Martin Luther King Pl, Louisville, KY 40202 USA.
EM drussell20@gmail.com
FU Tennessee Wildlife Resources Agency; Center for the Management,
Utilization, and Protection of Water Resources at Tennessee
Technological University (TTU); USGS Tennessee Cooperative Fishery
Research Unit
FX The use of trade, product, industry, or firm names or products is for
informative purposes only and does not constitute an endorsement by the
US Government or the US Geological Survey. Funding for this research was
provided by the Tennessee Wildlife Resources Agency, the Center for the
Management, Utilization, and Protection of Water Resources at Tennessee
Technological University (TTU), and the USGS Tennessee Cooperative
Fishery Research Unit. We extend our thanks to J. Hammonds and S.
Henagar for their help in the field, as well as the many TTU graduate
students and anglers (especially Rob and Mary Kelly) who volunteered
their time and fish carcasses, respectively. This manuscript benefited
from constructive comments on earlier drafts by H.T. Mattingly, H.T.
Andrews, S. Reeser, M.C. Quist, and two anonymous reviewers.
NR 50
TC 0
Z9 0
U1 1
U2 12
PU HUMBOLDT FIELD RESEARCH INST
PI STEUBEN
PA PO BOX 9, STEUBEN, ME 04680-0009 USA
SN 1528-7092
J9 SOUTHEAST NAT
JI Southeast. Nat.
PD APR
PY 2013
VL 12
IS 1
BP 217
EP 232
DI 10.1656/058.012.0117
PG 16
WC Biodiversity Conservation; Ecology
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA 184DY
UT WOS:000321868900017
ER
PT J
AU Diana, JS
Egna, HS
Chopin, T
Peterson, MS
Cao, L
Pomeroy, R
Verdegem, M
Slack, WT
Bondad-Reantaso, MG
Cabello, F
AF Diana, James S.
Egna, Hillary S.
Chopin, Thierry
Peterson, Mark S.
Cao, Ling
Pomeroy, Robert
Verdegem, Marc
Slack, William T.
Bondad-Reantaso, Melba G.
Cabello, Felipe
TI Responsible Aquaculture in 2050: Valuing Local Conditions and Human
Innovations Will Be Key to Success
SO BIOSCIENCE
LA English
DT Article
DE human capacity development; integrated multitrophic aquaculture; best
management practices; recirculating aquaculture systems; responsible
aquaculture
ID LIFE-CYCLE ASSESSMENT; OREOCHROMIS-NILOTICUS; MARINE AQUACULTURE; ANIMAL
HEALTH; SYSTEMS; IMPROVEMENT; POPULATION; FISH; TECHNOLOGIES;
BIODIVERSITY
AB As aquaculture production expands, we must avoid mistakes made during increasing intensification of agriculture. Understanding environmental impacts and measures to mitigate them is important for designing responsible aquaculture production systems. There are four realistic goals that can make future aquaculture operations more sustainable and productive: (I) improvement of management practices to create more efficient and diverse systems at every production level; (2) emphasis on local decisionmaking, human capacity development, and collective action to generate productive aquaculture systems that fit into societal constraints and demands; (3) development of risk management efforts for all systems that reduce disease problems, eliminate antibiotic and drug abuse, and prevent exotic organism introduction into local waters; and (4) creation of systems to better identify more sustainably grown aquaculture products in the market and promote them to individual consumers. By 2050, seafood will be predominantly sourced through aquaculture, including not only finfish and invertebrates but also seaweeds.
C1 [Diana, James S.; Cao, Ling] Univ Michigan, Sch Nat Resources & Environm, Ann Arbor, MI 48109 USA.
[Egna, Hillary S.] Oregon State Univ, Aquaculture & Fisheries Collaborat Res Support Pr, Corvallis, OR 97331 USA.
[Chopin, Thierry] Univ New Brunswick, Canadian Integrated Multitroph Aquaculture Networ, St John, NB E2L 4L5, Canada.
[Peterson, Mark S.] Univ So Mississippi, Dept Coastal Sci, Ocean Springs, MS USA.
[Pomeroy, Robert] Univ Connecticut, Groton, CT USA.
[Verdegem, Marc] Wageningen Univ, Aquaculture & Fisheries Grp, NL-6700 AP Wageningen, Netherlands.
[Slack, William T.] USA, Engineer Res & Dev Ctr, Vicksburg, MS USA.
[Bondad-Reantaso, Melba G.] UN, FAO, Dept Fisheries & Aquaculture, Rome, Italy.
[Cabello, Felipe] New York Med Coll, Dept Microbiol & Immunol, Valhalla, NY 10595 USA.
RP Diana, JS (reprint author), Univ Michigan, Sch Nat Resources & Environm, Ann Arbor, MI 48109 USA.
EM jimd@umich.edu
RI Verdegem, marc/C-6659-2014; Chopin, Thierry/L-9532-2015
OI Verdegem, marc/0000-0002-2058-3894; Chopin, Thierry/0000-0003-2981-7324
FU US Agency for International Development Cooperative Agreement Leader
with Associates through the Aquaculture and Fisheries Collaborative
Research Support Program (Aqua Fish CRSP) [EPP-A-00-06-00012-00]
FX This article is the outcome of a workshop and symposium presentation
entitled "The effects of semi-intensive aquaculture on biodiversity in
nearshore and inland waters," which was held at the annual meeting of
the American Fisheries Society in September 2011. Financial support for
this symposium was from US Agency for International Development
Cooperative Agreement Leader with Associates grant no.
EPP-A-00-06-00012-00 through the Aquaculture and Fisheries Collaborative
Research Support Program (Aqua Fish CRSP) and also by participating
institutions. This is contribution no. 1399 of the Aqua Fish CRSP.
NR 56
TC 29
Z9 29
U1 9
U2 108
PU AMER INST BIOLOGICAL SCI
PI WASHINGTON
PA 1444 EYE ST, NW, STE 200, WASHINGTON, DC 20005 USA
SN 0006-3568
J9 BIOSCIENCE
JI Bioscience
PD APR
PY 2013
VL 63
IS 4
BP 255
EP 262
DI 10.1525/bio.2013.63.4.5
PG 8
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA 165NX
UT WOS:000320491700011
ER
PT J
AU Gates, DH
Aldridge, JM
Wilken, JM
AF Gates, Deanna H.
Aldridge, Jennifer M.
Wilken, Jason M.
TI Kinematic comparison of walking on uneven ground using powered and
unpowered prostheses
SO CLINICAL BIOMECHANICS
LA English
DT Article
DE Gait; Transtibial amputation; Prosthetic feet; Uneven terrain
ID DESTABILIZING ROCK SURFACE; HUMAN JOINT MOTION; TRANSTIBIAL AMPUTATIONS;
ISB RECOMMENDATION; GAIT; ANKLE; SYSTEM; DEFINITIONS; AMPUTEES; KINETICS
AB Background: Recent research has focused on the design of intelligent prosthetic ankle devices with the goal of adapting behavior of the device to accommodate all walking surfaces that an individual encounters in daily life. To date, no studies have looked at how such devices perform on uneven terrain.
Methods: 11 young adults with unilateral transtibial amputation participated in two data collection sessions spaced approximately 3 weeks apart. In each session they walked across a loose rock surface at three controlled speeds. In the first session, they wore a passive, energy storage and return prosthesis and in the second, they wore a powered prosthesis (BiOM, iWalk, Bedford, MA, USA).
Findings: Subjects had a 10% faster self-selected walking speed when wearing the powered (1.16 m/s) compared to unpowered prosthesis (1.05 m/s; p = 0.031). They walked with increased ankle plantarflexion on their prosthetic limb throughout the gait cycle when wearing the powered compared to unpowered prosthesis. This was especially evident in the increased plantarflexion during push-off (p < 0.001). There was a small (<3 degrees), but statistically significant decrease in knee flexion during early stance when wearing the powered device (p = 0.045). Otherwise, the kinematics of the knee and hip were nearly identical when wearing the different devices. Subjects had decreased medial-lateral motion of their center of mass when wearing the powered prosthesis (p = 0.020), but there were no differences in medial-lateral margins of stability between the devices (p = 0.662).
Interpretation: Subjects did not significantly alter their proximal joint kinematics on this irregular surface as a result of the addition of power. Published by Elsevier Ltd.
C1 [Gates, Deanna H.; Aldridge, Jennifer M.; Wilken, Jason M.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA.
RP Wilken, JM (reprint author), Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA.
EM Jason.wilken@us.army.mil
OI Wilken, Jason/0000-0002-5556-7667
FU U.S. Army Telemedicine & Advanced Technology Research Center; Center for
Rehabilitation Sciences Research
FX Partial support was provided by the U.S. Army Telemedicine & Advanced
Technology Research Center and the Center for Rehabilitation Sciences
Research. We would like to thank Jordan Sturdy for his help with data
processing and the CFI prosthetics team for their contribution to this
effort.
NR 26
TC 8
Z9 8
U1 4
U2 25
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0268-0033
J9 CLIN BIOMECH
JI Clin. Biomech.
PD APR
PY 2013
VL 28
IS 4
BP 467
EP 472
DI 10.1016/j.clinbiomech.2013.03.005
PG 6
WC Engineering, Biomedical; Orthopedics; Sport Sciences
SC Engineering; Orthopedics; Sport Sciences
GA 170CD
UT WOS:000320826300017
PM 23602128
ER
PT J
AU Hockersmith, EE
Brooks, G
Dumdei, ND
Achord, S
AF Hockersmith, Eric E.
Brooks, Gabriel
Dumdei, Nathan D.
Achord, Stephen
TI A Lightweight Battery for Backpack Electrofishing
SO NORTH AMERICAN JOURNAL OF FISHERIES MANAGEMENT
LA English
DT Article
AB A lithium ion battery was modified to replace the conventional sealed lead acid battery used to operate a backpack electrofishing unit. Specifications and performance of the lithium ion battery were compared with those of a lead acid battery of similar capacity. The lithium ion battery was 76% lighter in weight than the lead acid battery, reducing the overall weight of a Smith-Root model 12 backpack electrofishing unit and battery by 55%. Including the cost of a charger and parts to make the battery compatible with an electroshocking unit, the lithium ion battery and charger cost was 26% less than that of the lead acid battery and charger. Bench tests indicated the lithium ion battery provided 91% and 98% of the operating time of the lead acid battery per charge when the settings were 300V at 90Hz and 500V at 90Hz, respectively. The fuel gauge (battery discharge indicator) on the lithium ion battery, which was absent in the lead acid battery, provided the ability for a user to assess the remaining charge level while in the field. The lithium ion battery provided similar performance with a significant reduction in weight and cost compared with a conventional lead acid battery for backpack electrofishing. The lighter weight of the backpack electrofishing unit using the lithium ion battery can reduce fatigue and the risk of fatigue-related injuries to field crews.
C1 [Hockersmith, Eric E.] US Army Corp Engineers, Northwestern Div, Walla Walla, WA 99362 USA.
[Brooks, Gabriel; Dumdei, Nathan D.; Achord, Stephen] NOAA, Natl Marine Fisheries Serv, NW Fisheries Sci Ctr, Fish Ecol Div, Seattle, WA 98112 USA.
RP Hockersmith, EE (reprint author), US Army Corp Engineers, Northwestern Div, 201 North 3rd, Walla Walla, WA 99362 USA.
EM eric.e.hockersmith@usace.army.mil
FU U.S. Department of Energy, Bonneville Power Administration (BPA),
Portland, Oregon [004981]
FX This work was funded in part by the U.S. Department of Energy,
Bonneville Power Administration (BPA), Portland, Oregon (contract
004981). We thank the following for their assistance in conducting this
study: Deborah Docherty from BPA, and Gordon Axel, Shane Collier, John
Ferguson, Bruce Jonasson, Jesse Lamb, Kenneth McIntyre, Jeff Moser,
Richard Nelson, Matthew Nesbit, Neil Paasch, Sam Rambo, and Louis Tullos
from the National Marine Fisheries Service. Reference to trade names
does not imply endorsement by the U.S. Government.
NR 8
TC 0
Z9 0
U1 0
U2 3
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 0275-5947
J9 N AM J FISH MANAGE
JI North Am. J. Fish Manage.
PD APR 1
PY 2013
VL 33
IS 2
BP 265
EP 268
DI 10.1080/02755947.2013.765526
PG 4
WC Fisheries
SC Fisheries
GA 167PD
UT WOS:000320643000004
ER
PT J
AU Thomas, MJ
Peterson, ML
Friedenberg, N
Van Eenennaam, JP
Johnson, JR
Hoover, JJ
Klimley, AP
AF Thomas, Michael J.
Peterson, Matthew L.
Friedenberg, Nick
Van Eenennaam, Joel P.
Johnson, Joseph R.
Hoover, Jan Jeffrey
Klimley, A. Peter
TI Stranding of Spawning Run Green Sturgeon in the Sacramento River:
Post-Rescue Movements and Potential Population-Level Effects
SO NORTH AMERICAN JOURNAL OF FISHERIES MANAGEMENT
LA English
DT Article
ID ACIPENSER-MEDIROSTRIS; LIFE-HISTORY; MIGRATION; CALIFORNIA; PATTERNS;
KLAMATH; ENTRAINMENT; HABITAT; SIZE; RISK
AB The lower portion of the Sacramento River, California, has been highly engineered to protect low-lying surrounding communities from annual flood events. While engineered floodplains have provided adequate protection for the surrounding communities, there remain unintended consequences to migratory fish that become stranded during high flow events. In April 2011, we rescued 24 threatened Green Sturgeon Acipenser medirostris that were stranded in two flood diversions along the Sacramento River. We tagged these 24 Green Sturgeon with acoustic tags and analyzed their survival and migration success to their spawning grounds. Additionally, we provided a population viability analysis to show the potential impacts of stranding and the benefits of conducting rescues at the population level. We found that 17 of these 24 individuals continued their upstream migration to the spawning grounds. Modeling suggests that recurrent stranding of a similar magnitude without rescue could affect the long-term viability of Green Sturgeon in the Sacramento River. Population viability analyses of rescue predicted a 7% decrease below the population baseline model over 50years as opposed to 33% without rescue. Despite the mitigated impact to the population with rescue, fish passage improvements should be considered as a long-term goal for preventing population risks at flood control diversions.
C1 [Thomas, Michael J.; Peterson, Matthew L.; Klimley, A. Peter] Univ Calif Davis, Dept Wildlife Fisheries & Conservat Biol, Biotelemetry Lab, Davis, CA 95616 USA.
[Peterson, Matthew L.] FISHBIO, Chico, CA 95928 USA.
[Friedenberg, Nick] Appl Biomath, Setauket, NY 11733 USA.
[Van Eenennaam, Joel P.] Univ Calif Davis, Finfish Reprod Physiol Lab, Dept Anim Sci, Davis, CA 95616 USA.
[Johnson, Joseph R.] Calif Dept Fish & Game, Rancho Cordova, CA 95670 USA.
[Hoover, Jan Jeffrey] US Army Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Thomas, MJ (reprint author), Univ Calif Davis, Dept Wildlife Fisheries & Conservat Biol, Biotelemetry Lab, 1 Shields Ave, Davis, CA 95616 USA.
EM mjthomas@ucdavis.edu
FU U.S. Army Corps of Engineers, Sacramento District
FX We are grateful to the many staff members and volunteers of the
California Department of Fish and Game for their exhaustive efforts to
capture and return sturgeon back to the river. Without the foresight of
agency personnel to include a telemetry component to the rescue, this
study would not have been possible. Tagging support was provided by
Brian Mahardja and Emily Miller from University of California, Davis,
and Robert Chase from the U.S. Bureau of Reclamation. Funding for
population modeling was provided by the U.S. Army Corps of Engineers,
Sacramento District. Permission to publish was provided by the Chief of
Engineers.
NR 33
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U1 0
U2 18
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 0275-5947
J9 N AM J FISH MANAGE
JI North Am. J. Fish Manage.
PD APR 1
PY 2013
VL 33
IS 2
BP 287
EP 297
DI 10.1080/02755947.2012.758201
PG 11
WC Fisheries
SC Fisheries
GA 167PD
UT WOS:000320643000007
ER
PT J
AU Bijl, P
Maurer, T
Wilson, DL
AF Bijl, Piet
Maurer, Tana
Wilson, David L.
TI Target Search and Detection
SO OPTICAL ENGINEERING
LA English
DT Editorial Material
C1 [Bijl, Piet] TNO BSS Human Factors, NL-3769 ZG Soesterberg, Netherlands.
[Maurer, Tana; Wilson, David L.] USA, RDECOM, CERDEC, NVESD, Ft Belvoir, VA 22060 USA.
RP Bijl, P (reprint author), TNO BSS Human Factors, Kampweg 5, NL-3769 ZG Soesterberg, Netherlands.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA
SN 0091-3286
J9 OPT ENG
JI Opt. Eng.
PD APR
PY 2013
VL 52
IS 4
AR 041101
DI 10.1117/1.OE.52.4.041101
PG 1
WC Optics
SC Optics
GA 151DB
UT WOS:000319439700004
ER
PT J
AU Camp, HA
Moyer, S
Moore, RK
AF Camp, H. Alan
Moyer, Steve
Moore, Richard K.
TI Performance characteristics of the masked target transform volume
clutter metric
SO OPTICAL ENGINEERING
LA English
DT Article
DE clutter metric; masked target transform volume
ID ACQUISITION PERFORMANCE
AB Prior work has shown that the masked target transform volume (MTTV) clutter metric provides a measure of scene clutter that better correlates to measured probability of detection for human observers than several previously published clutter metrics. Several factors involved in using the MTTV to assess clutter in imagery are discussed here. A previously published modification to the MTTV metric to provide a normalized output value comparable across different image sets regardless of scene size is reviewed. Initial MTTV development required knowledge of a scene's target signature and produced an unbounded metric value. Metric behavior is discussed for the case in which an average of several target signatures is used in place of a specific target signature. This allows the MTTV to be calculated for images that do not contain a target. It is shown that the user may trade computational efficiency with metric accuracy to suit a particular application. The sensitivity of the metric to variations in image noise level, target segmentation error, and viewing distance are also presented. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
C1 [Camp, H. Alan] EOIR Technol Inc, Fredericksburg, VA 22408 USA.
[Moyer, Steve] USA, RDECOM, CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
[Moore, Richard K.] USA, ATEC, Redstone Test Ctr, Redstone Arsenal, AL 35898 USA.
RP Camp, HA (reprint author), EOIR Technol Inc, Fredericksburg, VA 22408 USA.
EM hacamp@eoir.com
NR 20
TC 0
Z9 0
U1 0
U2 2
PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA
SN 0091-3286
J9 OPT ENG
JI Opt. Eng.
PD APR
PY 2013
VL 52
IS 4
AR 041104
DI 10.1117/1.OE.52.4.041104
PG 9
WC Optics
SC Optics
GA 151DB
UT WOS:000319439700007
ER
PT J
AU Maurer, T
Wilson, DL
Driggers, RG
AF Maurer, Tana
Wilson, David L.
Driggers, Ronald G.
TI Search and detection modeling of military imaging systems
SO OPTICAL ENGINEERING
LA English
DT Article
DE search; target acquisition; target detection; ACQUIRE; ACQUIRE-LC;
DETECT-05; search time; time-limited search; clutter; image-based
modeling; targeting task performance metric
ID TIME-LIMITED SEARCH; PERFORMANCE; VISION; IMPROVEMENTS; CLUTTER
AB For more than 50 years, the U. S. Army RDECOM CERDEC Night Vision and Electronic Sensors Directorate (NVESD) has been studying the science behind the human processes of searching and detecting, and using that knowledge to develop and refine its models for military imaging systems. Modeling how human observers perform military tasks while using imaging systems in the field and linking that model with the physics of the systems has resulted in the comprehensive sensor models we have today. These models are used by the government, military, industry, and academia for sensor development, sensor system acquisition, military tactics development, and war-gaming. From the original hypothesis put forth by John Johnson in 1958, to modeling time-limited search, to modeling the impact of motion on target detection, to modeling target acquisition performance in different spectral bands, the concept of search has a wide-ranging history. Our purpose is to present a snapshot of that history; as such, it will begin with a description of the search-modeling task, followed by a summary of highlights from the early years, and concluding with a discussion of search and detection modeling today and the changing battlefield. Some of the topics to be discussed will be classic search, clutter, computational vision models and the ACQUIRE model with its variants. We do not claim to present a complete history here, but rather a look at some of the work that has been done, and this is meant to be an introduction to an extensive amount of work on a complex topic. That said, it is hoped that this overview of the history of search and detection modeling of military imaging systems pursued by NVESD directly, or in association with other government agencies or contractors, will provide both the novice and experienced search modeler with a useful historical summary and an introduction to current issues and future challenges. c 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)
C1 [Maurer, Tana; Wilson, David L.] USA, Night Vis & Elect Sensors Directorate, Res Dev & Engn Command, CERDEC, Ft Belvoir, VA 22060 USA.
[Driggers, Ronald G.] USN, Res Lab, Washington, DC 20375 USA.
RP Maurer, T (reprint author), USA, Night Vis & Elect Sensors Directorate, Res Dev & Engn Command, CERDEC, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA.
EM info@nvl.army.mil
NR 37
TC 5
Z9 5
U1 0
U2 5
PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA
SN 0091-3286
J9 OPT ENG
JI Opt. Eng.
PD APR
PY 2013
VL 52
IS 4
AR 041108
DI 10.1117/1.OE.52.4.041108
PG 11
WC Optics
SC Optics
GA 151DB
UT WOS:000319439700011
ER
PT J
AU Vollmerhausen, RH
Driggers, RG
Hodgkin, VA
AF Vollmerhausen, Richard H.
Driggers, Ronald G.
Hodgkin, Van A.
TI Night illumination in the near- and short-wave infrared spectral bands
and the potential for silicon and indium-gallium-arsenide imagers to
perform night targeting
SO OPTICAL ENGINEERING
LA English
DT Article
DE airglow; night illumination; night vision imaging; silicon focal plane
array; indium-gallium-arsenide
ID WIND IMAGING INTERFEROMETER; AIRGLOW EMISSIONS; TIDAL INFLUENCE;
MESOSPHERIC OH; TEMPERATURES; O-2; SATELLITE; OXYGEN; MODEL
AB On a moonless night, the primary source of natural illumination in the near infrared and short-wave infrared spectral bands is airglow. We use data gathered by astronomers and atmospheric scientists to estimate the magnitude and variability of airglow ground illumination. Based on that foundation, we analyze the target acquisition performance of imagers that use silicon and indium-gallium-arsenide focal plane arrays. (C) 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)
C1 [Vollmerhausen, Richard H.] Univ Delaware, Newark, DE 19716 USA.
[Driggers, Ronald G.] USN, Res Lab, Washington, DC 20375 USA.
[Hodgkin, Van A.] USA, Res & Dev Command, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA.
RP Vollmerhausen, RH (reprint author), Univ Delaware, Newark, DE 19716 USA.
EM vollmerhausen@hughes.net
FU U.S. Army Research and Development Command, Night Vision and
Electronic-Sensors Directorate at Fort Belvoir, Virginia
FX This work has been funded by the U.S. Army Research and Development
Command, Night Vision and Electronic-Sensors Directorate at Fort
Belvoir, Virginia.
NR 48
TC 2
Z9 2
U1 1
U2 3
PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA
SN 0091-3286
EI 1560-2303
J9 OPT ENG
JI Opt. Eng.
PD APR
PY 2013
VL 52
IS 4
AR 043202
DI 10.1117/1.OE.52.4.043202
PG 8
WC Optics
SC Optics
GA 151DB
UT WOS:000319439700015
ER
PT J
AU Andrew, SP
Beidleman, BA
Fulco, CS
Yates, BA
Muza, SR
AF Andrew, Sean P.
Beidleman, Beth A.
Fulco, Charles S.
Yates, Brandon A.
Muza, Stephen R.
TI Two days of staging at moderate altitude results in similar time-trial
performance impairments at 4300m compared to direct ascent and stay for
two days at 4300m
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Andrew, Sean P.; Beidleman, Beth A.; Fulco, Charles S.; Yates, Brandon A.; Muza, Stephen R.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 715.5
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860503545
ER
PT J
AU Arsenault, JE
Noyes, M
Funderburk, L
AF Arsenault, Joanne E.
Noyes, Michael
Funderburk, LesLee
TI Attitudes and behaviors of overweight or obese US Army Soldiers
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Arsenault, Joanne E.] RTI Int, Res Triangle Pk, NC USA.
[Noyes, Michael] 163rd Med Battal, Seoul, South Korea.
[Funderburk, LesLee] William Beaumont Army Med Ctr, Ft Bliss, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 349.5
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 157GG
UT WOS:000319883501546
ER
PT J
AU Austin, KG
McGraw, SM
Lieberman, H
AF Austin, Krista Gail
McGraw, Susan M.
Lieberman, Harris
TI Dietary supplement use is associated with positive mood states in US
Military and Coast Guard personnel
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Austin, Krista Gail; McGraw, Susan M.; Lieberman, Harris] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 242.7
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 157GG
UT WOS:000319883501530
ER
PT J
AU Banwarth, EA
McAllister, E
Rothschadl, K
Wampfler, A
Mendis, C
Jett, M
AF Banwarth, Emily Anne
McAllister, Erin
Rothschadl, Kendra
Wampfler, Ashlynne
Mendis, Chanaka
Jett, Marti
TI Effect of Pathway-Interconnectors in SEB-Induced Apoptosis Related
Events in Human PBMCs
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Banwarth, Emily Anne; McAllister, Erin; Rothschadl, Kendra; Wampfler, Ashlynne; Mendis, Chanaka] Univ Wisconsin Platteville, Platteville, WI USA.
[Jett, Marti] USA, Ctr Environm Hlth Res, Syst Biol Enterprise USA Med Command MEDCOM, Ft Detrick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 604.4
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 157GG
UT WOS:000319883500627
ER
PT J
AU Beidleman, BA
Fulco, CS
Kenefick, RW
Cymerman, A
Staab, JE
Muza, SR
AF Beidleman, Beth A.
Fulco, Charles S.
Kenefick, Robert W.
Cymerman, Allen
Staab, Janet E.
Muza, Stephen R.
TI Two Days of Staging at Moderate Altitude Reduces Acute Mountain Sickness
Upon Further Ascent to 4300 m in Unacclimatized Lowlanders
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Beidleman, Beth A.; Fulco, Charles S.; Kenefick, Robert W.; Cymerman, Allen; Staab, Janet E.; Muza, Stephen R.] USA, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 715.4
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860503345
ER
PT J
AU Biedenkapp, J
Grohmann, K
McClung, J
Farina, E
Murphy, N
Cummings, C
Lieberman, H
AF Biedenkapp, Joseph
Grohmann, Kyle
McClung, James
Farina, Emily
Murphy, Nancy
Cummings, Christopher
Lieberman, Harris
TI Biochemical and mood changes dissociate during exposure to intense
military training
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Biedenkapp, Joseph; McClung, James; Farina, Emily; Murphy, Nancy; Cummings, Christopher; Lieberman, Harris] USA, Environm Med Res Inst, Natick, MA 01760 USA.
[Biedenkapp, Joseph; Farina, Emily; Cummings, Christopher] Oak Ridge Inst Sci & Educ, Belcamp, MD USA.
[Grohmann, Kyle] USA, John F Kennedy Special Warfare Ctr, Ft Bragg, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 936.12
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860506225
ER
PT J
AU Blake, CE
Rosemond, TN
Torres-McGehee, TM
Frongillo, EA
Burke, MP
Lenkerd, A
Minton, DM
Cable, LTCS
Glover, SH
AF Blake, Christine E.
Rosemond, Tiara N.
Torres-McGehee, Toni M.
Frongillo, Edward A.
Burke, Michael P.
Lenkerd, Allison
Minton, Dawn M.
Cable, L. T. C. Sonya
Glover, Saundra H.
TI Drill Sergeants' two contrasting approaches to "soldierization" and
instilling healthy eating behaviors in soldiers
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Blake, Christine E.; Rosemond, Tiara N.; Torres-McGehee, Toni M.; Frongillo, Edward A.; Burke, Michael P.; Lenkerd, Allison; Minton, Dawn M.; Glover, Saundra H.] Univ S Carolina, Columbia, SC 29208 USA.
[Cable, L. T. C. Sonya] USA, Initial Mil Training Ctr Excellence, Ft Eustis, VA USA.
RI Blake, Christine/F-2277-2013
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 231.4
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 157GG
UT WOS:000319883503377
ER
PT J
AU Borkovec, AR
Koltermann, K
Martin, A
Mendis, C
Jett, M
AF Borkovec, Ashley Rose
Koltermann, Kayla
Martin, Ashley
Mendis, Chanaka
Jett, Marti
TI Early Intervention by Targeting Inhibitors of Multiple Signal
Transduction Pathways in LPS Induced Human PBMCs
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Borkovec, Ashley Rose; Koltermann, Kayla; Martin, Ashley; Mendis, Chanaka] Univ Wisconsin Platteville, Platteville, WI USA.
[Jett, Marti] USA, Ctr Environm Hlth Res, Syst Biol Enterprise US Army Med Command, Ft Detrick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 604.5
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 157GG
UT WOS:000319883501611
ER
PT J
AU Bowman, P
Bynum, JA
McFaul, SJ
AF Bowman, Phillip
Bynum, James A.
McFaul, Steve J.
TI The genetic response of human endothelial cells to exposure to varying
oxygen concentration.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Bowman, Phillip; Bynum, James A.; McFaul, Steve J.] USA, Inst Surg Res, DCR, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 717.10
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860505088
ER
PT J
AU Bowman, P
Bynum, JA
McFaul, SJ
AF Bowman, Phillip
Bynum, James A.
McFaul, Steve J.
TI An In Vitro Hypoxia/Reoxygenation Model of Ischemia/Reperfusion Injury
with Glucose Oxidase And Catalase
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Bowman, Phillip; Bynum, James A.; McFaul, Steve J.] USA, Inst Surg Res, DCR, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 717.11
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860503115
ER
PT J
AU Bukhari, AS
Young, AJ
McGraw, SM
Roberts, SB
Das, SK
AF Bukhari, Asma Sultana
Young, Andrew J.
McGraw, Susan M.
Roberts, Susan B.
Das, Sai Krupa
TI Level of Interest in a Weight Management Program Among Adult US Military
Dependents
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Bukhari, Asma Sultana; Young, Andrew J.; McGraw, Susan M.] USA, Inst Environm Med USARIEM, Mil Nutr Dept, Natick, MA 01760 USA.
[Roberts, Susan B.; Das, Sai Krupa] Tufts Univ, Energy Metab Lab, JM, HNRCA,USDA, Boston, MA 02111 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 854.5
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 157GG
UT WOS:000319883503294
ER
PT J
AU Cao, J
Pasiakos, SM
Margolis, LM
Whigham, LD
McClung, JP
Young, AJ
Combs, GF
AF Cao, Jay
Pasiakos, Stefan M.
Margolis, Lee M.
Whigham, Leah D.
McClung, James P.
Young, Andrew J.
Combs, Gerald F.
TI Calcium homeostasis and bone metabolic responses to protein diets and
energy restriction: a randomized control trial
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Cao, Jay; Whigham, Leah D.; Combs, Gerald F.] USDA ARS, Grand Forks Human Nutr Res Ctr, Grand Forks, ND 58202 USA.
[Pasiakos, Stefan M.; Margolis, Lee M.; McClung, James P.; Young, Andrew J.] USA, Environm Med Res Inst, Natick, MA 01760 USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 249.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 157GG
UT WOS:000319883503199
ER
PT J
AU Carbone, JW
Margolis, LM
McClung, JP
Cao, JJ
Young, AJ
Pasiakos, SM
AF Carbone, John Walter
Margolis, Lee M.
McClung, James P.
Cao, Jay J.
Young, Andrew J.
Pasiakos, Stefan M.
TI Energy intake modulates intramuscular mTORC1 signaling and
ubiquitin-mediated proteolysis during energy deficit independent of
dietary protein variations
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Carbone, John Walter] Eastern Michigan Univ, Sch Hlth Sci, Ypsilanti, MI 48197 USA.
[Margolis, Lee M.; McClung, James P.; Young, Andrew J.; Pasiakos, Stefan M.] USA, Environm Med Res Inst, Natick, MA 01760 USA.
[Cao, Jay J.] USDA ARS, Grand Forks Human Nutr Res Ctr, Grand Forks, ND 58202 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 631.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 157GG
UT WOS:000319883505212
ER
PT J
AU Clarke, DC
Zhou, D
Inman, W
Barker, CJ
Leon, LR
Lauffenburger, DA
AF Clarke, David C.
Zhou, Dennis
Inman, Walker
Barker, Caroline J.
Leon, Lisa R.
Lauffenburger, Douglas A.
TI A computer-controlled system for simulating heat stroke in vitro
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Clarke, David C.; Zhou, Dennis; Inman, Walker; Barker, Caroline J.; Lauffenburger, Douglas A.] MIT, Dept Biol Engn, Cambridge, MA 02139 USA.
[Leon, Lisa R.] USA, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 1201.8
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860500472
ER
PT J
AU Dubick, MA
Klemcke, HG
Grubbs, DL
Barr, JL
Rose, R
AF Dubick, Michael A.
Klemcke, Harold G.
Grubbs, Dana L.
Barr, Johnny L.
Rose, Rajiv
TI Tissue antioxidant status in hemorrhaged inbred rat strains fed diets
for 9 weeks varying in levels of methyl group donors
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Dubick, Michael A.; Klemcke, Harold G.; Grubbs, Dana L.; Barr, Johnny L.; Rose, Rajiv] USA, DCR, Inst Surg Res, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 1193.3
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860502422
ER
PT J
AU Farina, EK
Grohmann, K
Biedenkapp, JC
McClung, JP
Lieberman, HR
AF Farina, Emily Kristin
Grohmann, Kyle
Biedenkapp, Joseph C.
McClung, James P.
Lieberman, Harris R.
TI Baseline serum n-3 eicosapentaenoic acid concentration is associated
with subsequent mood disturbance during the acute stress of military
survival school training
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Farina, Emily Kristin; Biedenkapp, Joseph C.; McClung, James P.; Lieberman, Harris R.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA.
[Farina, Emily Kristin; Biedenkapp, Joseph C.] Oak Ridge Inst Sci & Educ, Belcamp, MD USA.
[Grohmann, Kyle] USA, John F Kennedy Special Warfare Ctr, Ft Bragg, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 1072.18
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 157GG
UT WOS:000319883505011
ER
PT J
AU Hamilton, LR
Myers, TM
AF Hamilton, Lindsey R.
Myers, Todd M.
TI Bioscavengers to protect against chemical warfare nerve agents: safety
of adenovirus-driven expression of butyrylcholinesterase in macaques
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Hamilton, Lindsey R.; Myers, Todd M.] USA, Analyt Toxicol Div, Med Res Inst Chem Def, Aberdeen Proving Ground, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 5
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 662.8
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860502210
ER
PT J
AU Harvey, R
Barnes, JN
Charkoudian, N
Curry, TB
Eisenach, JH
Hart, ECJ
Joyner, MJ
AF Harvey, Ronee
Barnes, Jill N.
Charkoudian, Nisha
Curry, Timothy B.
Eisenach, John H.
Hart, Emma C. J.
Joyner, Michael J.
TI Forearm vasodilator response to isoproterenol in premenopausal and
postmenopausal women
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Harvey, Ronee] Mayo Clin, Coll Med, Rochester, MN USA.
[Barnes, Jill N.; Curry, Timothy B.; Eisenach, John H.; Joyner, Michael J.] Mayo Clin, Dept Anesthesiol, Rochester, MN USA.
[Charkoudian, Nisha] USA, Environm Med Res Inst, Natick, MA 01760 USA.
[Hart, Emma C. J.] Univ Bristol, Sch Physiol & Pharmacol, Bristol, Avon, England.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 927.4
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860504554
ER
PT J
AU Hinojosa-Laborde, C
Shade, R
Muniz, G
Bauer, C
Convertino, V
AF Hinojosa-Laborde, Carmen
Shade, Robert
Muniz, Gary
Bauer, Cassondra
Convertino, Victor
TI Comparison of hemodynamic responses to lower body negative pressure and
hemorrhage in baboons
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Hinojosa-Laborde, Carmen; Muniz, Gary; Convertino, Victor] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Shade, Robert; Bauer, Cassondra] Texas Biomed Res Inst, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 1206.2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860502428
ER
PT J
AU Houle, KE
Kantner, BJ
Brechue, WF
AF Houle, Katherine E.
Kantner, Bryan J.
Brechue, William F.
TI Dissociation of recovery of muscle activation and force following a
sustained maximal isometric contraction
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Houle, Katherine E.; Brechue, William F.] US Mil Acad, West Point, NY 10996 USA.
[Kantner, Bryan J.] Philadelphia Coll Osteopat Med, Philadelphia, PA USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 1152.19
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860500062
ER
PT J
AU Hughes, JM
Fellin, RE
Walker, LA
Frykman, PN
Seay, JF
AF Hughes, Julie Marie
Fellin, Rebecca Elizabeth
Walker, Leila Anne
Frykman, Peter Northrop
Seay, Joseph Francis
TI Greater peak oxygen consumption is associated with lower bone strength
in soldiers
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Hughes, Julie Marie; Fellin, Rebecca Elizabeth; Walker, Leila Anne; Frykman, Peter Northrop; Seay, Joseph Francis] USA, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 941.2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860502317
ER
PT J
AU Jaligama, S
Kale, VM
Wilbanks, MS
Perkins, EJ
Meyer, SA
AF Jaligama, Sridhar
Kale, Vijay M.
Wilbanks, Mitchell S.
Perkins, Edward J.
Meyer, Sharon A.
TI Bone marrow inflammation precedes hexahydro-1-nitroso-3, 5-dinitro-1, 3,
5-triazine (MNX) induced delayed myelosuppression in rats.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Jaligama, Sridhar; Meyer, Sharon A.] Univ Louisiana Monroe, Monroe, LA USA.
[Kale, Vijay M.] Roseman Univ Hlth Sci, South Jordan, UT USA.
[Wilbanks, Mitchell S.; Perkins, Edward J.] USA, Engineer Res & Dev Ctr, Vicksburg, MS USA.
RI Jaligama, Sridhar/D-5533-2015
OI Jaligama, Sridhar/0000-0001-6374-3336
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 888.5
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860500285
ER
PT J
AU Jibitu, M
AF Jibitu, Meskerem
TI Psycho-Physiological Changes in Mouse Strain Submitted to Social Stress
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Jibitu, Meskerem] USA, Ctr Environm Hlth Res, Ft Detrick, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 5
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 936.11
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860506217
ER
PT J
AU Johnson, BD
van Helmond, N
Curry, TB
Convertino, VA
Joyner, MJ
AF Johnson, Blair David
van Helmond, Noud
Curry, Timothy B.
Convertino, Victor A.
Joyner, Michael J.
TI Hemodynamic responses during lower body negative pressure and hemorrhage
in humans
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Johnson, Blair David; van Helmond, Noud; Curry, Timothy B.; Joyner, Michael J.] Mayo Clin, Rochester, MN USA.
[van Helmond, Noud] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands.
[Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 1206.3
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860500474
ER
PT J
AU Kajih, T
Smith, J
Rusek, T
Kasten, S
Cerasoli, D
AF Kajih, Takwen
Smith, John
Rusek, Tom
Kasten, Shane
Cerasoli, Douglas
TI A Single Gas Chromatography/Mass Spectrometry Method for Detection of
Individual Enantiomers of a Broad Spectrum of G-Type Chemical Warfare
Nerve Agents
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Kajih, Takwen; Smith, John; Rusek, Tom; Kasten, Shane; Cerasoli, Douglas] USA, Med Res Inst Chem Def, Edgewood, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 7
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 559.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 157GG
UT WOS:000319883500190
ER
PT J
AU Kang, BH
Racicot, K
Kwon, YI
Apostolidis, E
AF Kang, Bou-Hee
Racicot, Kenneth
Kwon, Young-In
Apostolidis, Emmanouil
TI Evaluation of in vitro anti-hyperglycemic effect of Cinnamon cassia
derived phenolic phytochemicals
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Kang, Bou-Hee; Apostolidis, Emmanouil] Framingham State Univ, Framingham, MA USA.
[Racicot, Kenneth] USA, Natick Soldier Res Engn Ctr, Natick, MA 01760 USA.
[Kwon, Young-In] Hannam Univ, Taejon, South Korea.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 637.19
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 157GG
UT WOS:000319883505473
ER
PT J
AU Kay, VL
George, M
Soller, BR
Ryan, KL
Hinojosa-Laborde, C
Convertino, VA
Rickards, CA
AF Kay, Victoria Lee
George, Mebin
Soller, Babs R.
Ryan, Kathy L.
Hinojosa-Laborde, Carmen
Convertino, Victor A.
Rickards, Caroline A.
TI The role of differential oxygen distribution between the brain and
peripheral tissues on tolerance to induced central hypovolemia
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Kay, Victoria Lee; Rickards, Caroline A.] Univ N Texas, Hlth Sci Ctr, Ft Worth, TX USA.
[George, Mebin] ISS Inc, Champaign, IL USA.
[Soller, Babs R.] Reflectance Med Inc, Westborough, MA USA.
[Ryan, Kathy L.; Hinojosa-Laborde, Carmen; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 5
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA lb667
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860506298
ER
PT J
AU Leon, LR
Dineen, SM
Clarke, DC
AF Leon, Lisa R.
Dineen, Shauna M.
Clarke, David C.
TI Early Activation of Liver Apoptotic Signaling Pathways during Heat
Stroke Recovery in Mice
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Leon, Lisa R.; Dineen, Shauna M.] USA, Environm Med Res Inst, Natick, MA 01760 USA.
[Clarke, David C.] MIT, Dept Biol Engn, Cambridge, MA 02139 USA.
[Clarke, David C.] MIT, Ctr Cellular Decis Proc, Cambridge, MA 02139 USA.
NR 0
TC 0
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 1201.7
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860503278
ER
PT J
AU Leon, LR
Duran, RM
Helwig, BG
AF Leon, Lisa R.
Duran, Rocio M.
Helwig, Bryan G.
TI Complementing Heat Stroke: Activation and Amplification of the IL-6 and
Complement System during Heat Stroke Recovery in F344 Rats
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Leon, Lisa R.; Duran, Rocio M.; Helwig, Bryan G.] USA, Environm Med Res Inst, Natick, MA 01760 USA.
NR 0
TC 0
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 1201.6
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860500105
ER
PT J
AU Lynch, CM
Matheny, RW
AF Lynch, Christine M.
Matheny, Ronald W.
TI Lysophosphatidic acid-mediated phosphorylation of protein kinase D2 is
dependent on PKC delta
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Lynch, Christine M.; Matheny, Ronald W.] USA, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 831.16
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 157GG
UT WOS:000319883504371
ER
PT J
AU Margolis, LM
Cao, JJ
Whigham, LD
McClung, JP
Combs, GF
Young, AJ
Pasiakos, SM
AF Margolis, Lee M.
Cao, Jay J.
Whigham, Leah D.
McClung, James P.
Combs, Gerald F.
Young, Andrew J.
Pasiakos, Stefan M.
TI Dietary protein intake, energy deficit, and nitrogen balance in
normal-weight adults: a randomized controlled trial
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Margolis, Lee M.; McClung, James P.; Young, Andrew J.; Pasiakos, Stefan M.] USA, MND, Environm Med Res Inst, Natick, MA 01760 USA.
[Cao, Jay J.; Whigham, Leah D.; Combs, Gerald F.] ARS, USDA, Grand Forks Human Nutr Res Ctr, Grand Forks, ND USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 1075.11
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860504577
ER
PT J
AU McClung, JP
Gaffney-Stomberg, E
Lutz, LJ
Rood, JC
Cable, SJ
Pasiakos, SM
Young, AJ
AF McClung, James P.
Gaffney-Stomberg, Erin
Lutz, Laura J.
Rood, Jennifer C.
Cable, Sonya J.
Pasiakos, Stefan M.
Young, Andrew J.
TI Associations between vitamin D status and lipid profiles in military
recruits
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [McClung, James P.; Gaffney-Stomberg, Erin; Lutz, Laura J.; Pasiakos, Stefan M.; Young, Andrew J.] USA, Environm Med Res Inst, Natick, MA 01760 USA.
[Rood, Jennifer C.] Pennington Biomed Res Ctr, Baton Rouge, LA USA.
[Cable, Sonya J.] Initial Mil Training Ctr Excellence, Ft Eustis, VA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 635.3
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 157GG
UT WOS:000319883502481
ER
PT J
AU Moore, NLT
Gauchan, S
Genovese, RF
AF Moore, Nicole L. T.
Gauchan, Sangeeta
Genovese, Raymond F.
TI Adolescent traumatic stress experience shapes adulthood fear
conditioning and extinction responses
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Moore, Nicole L. T.; Gauchan, Sangeeta; Genovese, Raymond F.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Behav Biol Branch, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 661.11
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860504251
ER
PT J
AU Moyler, C
Wolf, DW
Oberbaum, M
Dorozko, M
Ives, JA
Muhie, S
Miller, SA
Jonas, WB
Jett, M
Hammamieh, R
AF Moyler, Candace
Wolf, Dana W.
Oberbaum, M.
Dorozko, M.
Ives, John A.
Muhie, Seid
Miller, Stacy A.
Jonas, Wayne B.
Jett, Marti
Hammamieh, Rasha
TI Gripp-Heel and the Antiviral Host-Cell Responses against Adenovirus
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Moyler, Candace; Muhie, Seid; Miller, Stacy A.; Jett, Marti; Hammamieh, Rasha] USA, Ctr Environm Hlth Res, Ft Detrick, MD USA.
[Wolf, Dana W.; Dorozko, M.] Hadassah Hebrew Univ, Med Ctr, Jerusalem, Israel.
[Oberbaum, M.] Shaare Zedek Med Ctr, Jerusalem, Israel.
[Ives, John A.; Jonas, Wayne B.] Samueli Inst, Alexandria, VA USA.
NR 0
TC 0
Z9 0
U1 0
U2 6
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 773.3
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 157GG
UT WOS:000319883501342
ER
PT J
AU Murphy, NE
Lin, GG
Wulff, CR
Gaffney-Stomberg, E
Young, AJ
McClung, JP
Pasiakos, SM
AF Murphy, Nancy E.
Lin, Gregory G.
Wulff, Charles R.
Gaffney-Stomberg, Erin
Young, Andrew J.
McClung, James P.
Pasiakos, Stefan M.
TI Divergent intramuscular mTORC1 signaling responses to habitual
consumption of milk-and soy-based energy restricted diets
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Murphy, Nancy E.; Lin, Gregory G.; Wulff, Charles R.; Gaffney-Stomberg, Erin; Young, Andrew J.; McClung, James P.; Pasiakos, Stefan M.] USA, Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA.
NR 0
TC 0
Z9 0
U1 2
U2 3
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 631.9
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 157GG
UT WOS:000319883501306
ER
PT J
AU Muza, SR
Kenefick, RW
Andrew, SP
Beidleman, BA
Fulco, CS
Hamilton, SW
AF Muza, Stephen Raymond
Kenefick, Robert W.
Andrew, Sean P.
Beidleman, Beth A.
Fulco, Charles S.
Hamilton, Scott W.
TI Altitude acclimatization and acute mountain sickness during a graded
ascent to 5896 m
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Muza, Stephen Raymond; Kenefick, Robert W.; Andrew, Sean P.; Beidleman, Beth A.; Fulco, Charles S.; Hamilton, Scott W.] USA, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 715.3
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860502239
ER
PT J
AU Oh, T
Klemcke, HG
AF Oh, T.
Klemcke, H. G.
TI Cardiac CARD9 mRNA expression in inbred rat strains divergent in
survival time after severe hemorrhage (STaH)
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Oh, T.; Klemcke, H. G.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 1212.6
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860501182
ER
PT J
AU Park, BS
Henning, PC
Khamoui, AV
Jo, E
Lee, SR
Zourdos, MC
Kim, DH
Yeh, MC
Kim, JS
AF Park, Bong-Sup
Henning, Paul C.
Khamoui, Andy V.
Jo, Edward
Lee, Sang-Rok
Zourdos, Michael C.
Kim, Do-Houn
Yeh, Ming-Chia
Kim, Jeong-Su
TI HMB Attenuates A Loss of Myofiber Cross-Sectional Area during Prolonged
Exercise with Calorie Restriction by Enhancing Regenerative Capacity
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Park, Bong-Sup; Khamoui, Andy V.; Jo, Edward; Kim, Do-Houn; Yeh, Ming-Chia; Kim, Jeong-Su] Florida State Univ, Tallahassee, FL 32306 USA.
[Henning, Paul C.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA.
[Lee, Sang-Rok] Univ Memphis, Memphis, TN 38152 USA.
[Zourdos, Michael C.] Florida Atlantic Univ, Boca Raton, FL 33431 USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 1076.5
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 157GG
UT WOS:000319883503166
ER
PT J
AU Pasiakos, SM
Wulff, CR
Murphy, NE
Gaffney-Stomberg, E
Young, AJ
McClung, JP
AF Pasiakos, Stefan M.
Wulff, Charles R.
Murphy, Nancy E.
Gaffney-Stomberg, Erin
Young, Andrew J.
McClung, James P.
TI High protein diets enhance body composition in rats: a comparative
analysis of milk-and soy-based energy restricted diets
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Pasiakos, Stefan M.; Wulff, Charles R.; Murphy, Nancy E.; Gaffney-Stomberg, Erin; Young, Andrew J.; McClung, James P.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 631.10
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 157GG
UT WOS:000319883501623
ER
PT J
AU Quinn, CM
Helwig, BG
Leon, LR
Ward, JA
Duran, RM
AF Quinn, Carrie M.
Helwig, Bryan G.
Leon, Lisa R.
Ward, Jermaine A.
Duran, Rocio M.
TI Efficacy of Geranylgeranylacetone for heat stroke recovery in Fischer
344 rats
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Quinn, Carrie M.; Helwig, Bryan G.; Leon, Lisa R.; Ward, Jermaine A.; Duran, Rocio M.] USA, Thermal Mt Med Div, Inst Environm Med, Natick, MA 01760 USA.
RI Quinn, Carrie/A-2558-2014
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 1201.5
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860503048
ER
PT J
AU Racicot, K
Arcidiacono, S
Chen, CY
Soares, J
AF Racicot, Kenneth
Arcidiacono, Steven
Chen, C. Y. (Oliver)
Soares, Jason
TI The impact of long-term storage on fermentability of human fecal
bacteria
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Racicot, Kenneth] USA, Combat Feeding Directorate, Natick Soldier Ctr, Natick, MA 01760 USA.
[Arcidiacono, Steven; Soares, Jason] USA, Warrior Sci & Tech Dir, Natick Soldier Ctr, Natick, MA 01760 USA.
[Racicot, Kenneth; Chen, C. Y. (Oliver)] Tufts Univ, Jean Mayer Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
NR 0
TC 0
Z9 0
U1 0
U2 9
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 1056.13
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860501401
ER
PT J
AU Rastogi, A
Stavchansky, S
Bowman, P
AF Rastogi, Ashish
Stavchansky, Salomon
Bowman, Phillip
TI Dependence of cytotoxicity of menadione and cytoprotection by
antioxidants in human endothelial cells on oxygen levels: Atmospheric
oxygen versus physiological levels
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Rastogi, Ashish; Bowman, Phillip] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Rastogi, Ashish] Geneva Fdn, Tacoma, WA USA.
[Stavchansky, Salomon] Univ Texas Austin, Austin, TX 78712 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 1143.11
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860504592
ER
PT J
AU Reed, E
AF Reed, Eddie
TI Translational Nucleotide Excision Repair in Triple Negative Breast
Cancer
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Reed, Eddie] USA, Mitchell Canc Inst, Mobile, AL USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 328.3
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860500152
ER
PT J
AU Santos, WJ
Waddy, E
Chakraborty, N
Gautam, A
Hoke, A
Jett, M
Hammamieh, R
AF Santos, William J.
Waddy, Edward
Chakraborty, Nabarun
Gautam, Aarti
Hoke, Allison
Jett, Marti
Hammamieh, Rasha
TI Pan-omic Approaches to Study the Effect of Microgravity on Skin
Endothelial Cells Submitted to Endotoxic Insult
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Santos, William J.; Waddy, Edward; Chakraborty, Nabarun; Gautam, Aarti; Hoke, Allison; Jett, Marti; Hammamieh, Rasha] USA, Ctr Environm Hlth Res, Ft Detrick, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 9
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 773.2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 157GG
UT WOS:000319883500288
ER
PT J
AU Schwacha, MG
Rani, M
Zhang, Q
AF Schwacha, Martin G.
Rani, Meenakshi
Zhang, Qiong
TI Gamma delta T-cells regulate myeloid cell activity after injury
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Schwacha, Martin G.; Rani, Meenakshi; Zhang, Qiong] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
[Schwacha, Martin G.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 648.3
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860503311
ER
PT J
AU Scrimgeour, AG
Joosen, MJ
Young, AJ
van Helden, HH
AF Scrimgeour, Angus Gray
Joosen, Marloes J.
Young, Andrew J.
van Helden, Herman H.
TI Euglycemia following IED-like blast exposure
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Scrimgeour, Angus Gray; Young, Andrew J.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA.
[Joosen, Marloes J.; van Helden, Herman H.] TNO Def Safety & Secur, Rijswijk, Netherlands.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 690.2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860502487
ER
PT J
AU Shade, RE
Hinojosa-Laborde, C
Muniz, G
Bauer, C
Convertino, V
AF Shade, Robert E.
Hinojosa-Laborde, Carmen
Muniz, Gary
Bauer, Cassondra
Convertino, Victor
TI Comparison of neurohumoral responses to lower body negative pressure and
hemorrhage in baboons
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Shade, Robert E.; Bauer, Cassondra] Texas Biomed Res Inst, San Antonio, TX USA.
[Hinojosa-Laborde, Carmen; Muniz, Gary; Convertino, Victor] USA, Inst Surg Res, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 1206.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860500107
ER
PT J
AU Srinivasan, S
Sowe, B
Miller, SA
Muhie, S
Chakraborty, N
Hammamieh, R
Meyerhoff, J
Jett, M
AF Srinivasan, Seshamalini
Sowe, Bintu
Miller, Stacy-Ann
Muhie, Seid
Chakraborty, Nabarun
Hammamieh, Rasha
Meyerhoff, James
Jett, Marti
TI Correlation between Genotypes and Behavioral Phenotypes in a Mouse Model
simulating aspects of Human Post-traumatic Stress Disorder (PTSD)
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Srinivasan, Seshamalini; Sowe, Bintu; Miller, Stacy-Ann; Muhie, Seid; Chakraborty, Nabarun; Hammamieh, Rasha; Meyerhoff, James; Jett, Marti] USA, Ctr Environm Hlth Res, Ft Detrick, MD USA.
NR 0
TC 0
Z9 0
U1 2
U2 12
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 569.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 157GG
UT WOS:000319883500199
ER
PT J
AU Staab, JE
Beidleman, BA
Fulco, CS
Grunbeck, MR
Guerriere, K
Raeburn, J
Muza, SR
AF Staab, Janet E.
Beidleman, Beth A.
Fulco, Charles S.
Grunbeck, Marie R.
Guerriere, Katelyn
Raeburn, Jennifer
Muza, Stephen R.
TI Two days of staging at moderate altitude induces 65-75% of the
ventilatory acclimatization achieved with two days of continuous
residence at 4300 m
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Staab, Janet E.; Beidleman, Beth A.; Fulco, Charles S.; Grunbeck, Marie R.; Guerriere, Katelyn; Raeburn, Jennifer; Muza, Stephen R.] USA, Environm Med Res Inst, Natick, MA 01760 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 715.6
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860504108
ER
PT J
AU Stallings, JD
Rakeesh, V
Helwig, BG
Baer, CE
Lewis, JA
Leon, LR
Reifman, J
Jackson, DA
AF Stallings, Jonathan Daniel
Rakeesh, Vineet
Helwig, Bryan G.
Baer, Christine E.
Lewis, John A.
Leon, Lisa R.
Reifman, Jaques
Jackson, David A.
TI Gene array analysis reveals consensus heat stress response in rat liver,
lung, heart, and kidney
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Stallings, Jonathan Daniel; Baer, Christine E.; Lewis, John A.; Jackson, David A.] USA, Ctr Environm Hlth Res, Ft Detrick, MD USA.
[Rakeesh, Vineet; Reifman, Jaques] Biotechnol HPC Software Applicat Inst, Frederick, MD USA.
[Helwig, Bryan G.; Leon, Lisa R.] USA, Environm Med Res Inst, Natick, MA 01760 USA.
RI Jackson, David/E-9984-2014
NR 0
TC 0
Z9 0
U1 0
U2 4
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA lb780
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860505321
ER
PT J
AU Tharion, WJ
Yokota, M
AF Tharion, William J.
Yokota, Miyo
TI Energy expenditure of military helicopter air crews during combat
missions assessed by modified factorial method.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Tharion, William J.; Yokota, Miyo] USA, Environm Med Res Inst, Natick, MA 01760 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 854.3
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 157GG
UT WOS:000319883501037
ER
PT J
AU Torres, I
Torres, L
Sondeen, J
Ji, L
Dubick, M
AF Torres Filho, Ivo
Torres, Luciana
Sondeen, Jill
Ji, Lisa
Dubick, Michael
TI Effects of Resuscitation Fluids following Hemorrhagic Shock on Venular
Glycocalyx in Rats
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Torres Filho, Ivo; Torres, Luciana; Sondeen, Jill; Ji, Lisa; Dubick, Michael] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 900.11
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860503578
ER
PT J
AU Torres, L
Sondeen, J
Ji, L
Dubick, M
Torres, I
AF Torres, Luciana
Sondeen, Jill
Ji, Lisa
Dubick, Michael
Torres Filho, Ivo
TI Effects of resuscitation fluids on endothelial glycocalyx (EG) and
coagulation in severe hemorrhagic shock (HS)
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Torres, Luciana; Sondeen, Jill; Ji, Lisa; Dubick, Michael; Torres Filho, Ivo] USA, Inst Surg Res, San Antonio, TX USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 900.10
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860503382
ER
PT J
AU Urso, ML
Carrigan, CT
Warren, GL
AF Urso, Maria L.
Carrigan, Christopher T.
Warren, Gordon L.
TI Matrix Metalloprotease Inhibition Negatively Affects Signaling Required
for Muscle Regeneration Post-traumatic Injury
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Urso, Maria L.; Carrigan, Christopher T.] USA, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA.
[Warren, Gordon L.] Georgia State Univ, Dept Phys Therapy, Atlanta, GA 30303 USA.
RI Warren, Gordon/A-9794-2008
OI Warren, Gordon/0000-0002-7073-8524
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 939.18
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860503182
ER
PT J
AU Urso, ML
Lee, AJ
Leon, LR
AF Urso, Maria L.
Lee, Andrew J.
Leon, Lisa R.
TI Heat stroke induces a local inflammatory response in skeletal muscle of
mice during 24 hours of recovery
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Urso, Maria L.; Lee, Andrew J.] USA, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA.
[Leon, Lisa R.] USA, Thermal Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 942.4
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860500327
ER
PT J
AU van Helmond, N
Johnson, BD
Curry, TB
Convertino, VA
Joyner, MJ
AF van Helmond, Noud
Johnson, Blair D.
Curry, Timothy B.
Convertino, Victor A.
Joyner, Michael J.
TI The Association between Pulse Pressure and Stroke Volume during Lower
Body Negative Pressure and Graded Hemorrhage
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [van Helmond, Noud] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands.
[Johnson, Blair D.; Curry, Timothy B.; Joyner, Michael J.] Mayo Clin, Rochester, MN USA.
[Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 1206.4
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860501176
ER
PT J
AU Yokota, M
Karis, AJ
Goetz, VC
Tharion, WJ
AF Yokota, Miyo
Karis, Anthony J.
Goetz, Victoria C.
Tharion, William J.
TI Evaluation of physiological strain in law enforcement personnel wearing
protective clothing and equipment
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
CY APR 20-24, 2013
CL Boston, MA
SP ASPET, British Pharmacol Soc (BPS)
C1 [Yokota, Miyo; Karis, Anthony J.; Goetz, Victoria C.; Tharion, William J.] USA, Biophys & Biomed Modeling Div, Environm Med Res Inst, Natick, MA 01760 USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2013
VL 27
MA 1201.9
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 156YK
UT WOS:000319860502426
ER
PT J
AU Patterson, MS
Gray, JP
Bortolin, G
Vantsevich, VV
AF Patterson, Michael S.
Gray, Jeremy P.
Bortolin, Gianantonio
Vantsevich, Vladimir V.
TI Fusion of driving and braking tire operational modes and analysis of
traction dynamics and energy efficiency of a 4 x 4 loader
SO JOURNAL OF TERRAMECHANICS
LA English
DT Article
DE 4 x 4 Loader single bucket loader; Brake-based traction control;
Interwheel limited slip differentials; Fusion; Math and computer models;
Traction and energy efficiency
ID ROAD
AB Brake-based traction control systems (TCs), which utilize the brake of a spinning wheel, are widely used in various vehicles. Recently, TCs were applied to all-wheel drive construction equipment. Such machines employ various types of driveline systems to control torque split between the drive wheels and thus improve vehicle traction performance. As experimental research showed, the interaction between the TC system and the axle drive can lead to unpredictable changes in vehicle traction. Lack of analytical work motivated a study of the interaction/impact of the two systems on each other and then traction a 4 x 4 single bucket loader. This paper presents an analytical and computer model of the loader's driveline system. Mechanical power distributions between the driving wheels are analyzed when a brake mechanism of a spinning wheel is on/off. Computer simulations were conducted on surfaces with different grip conditions of the four wheels, with longitudinal and lateral inclination of the loader when scooping the material. The paper discusses simulation results and presents fundamentals for the fusion of the driveline and TC systems to improve the loader's traction. (c) 2013 ISTVS. Published by Elsevier Ltd. All rights reserved.
C1 [Patterson, Michael S.; Gray, Jeremy P.] USA, Tank Automot Res Dev & Engn Ctr, Warren, MI USA.
[Bortolin, Gianantonio] Volvo Construct Equipment AB, Eskilstuna, Sweden.
[Vantsevich, Vladimir V.] Univ Alabama Birmingham, Birmingham, AL 35294 USA.
RP Vantsevich, VV (reprint author), Univ Alabama Birmingham, 1720 2nd Ave South, Birmingham, AL 35294 USA.
EM vantsevi@uab.edu
NR 24
TC 10
Z9 10
U1 2
U2 20
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4898
J9 J TERRAMECHANICS
JI J. Terramech.
PD APR
PY 2013
VL 50
IS 2
BP 133
EP 152
DI 10.1016/j.jterra.2013.01.003
PG 20
WC Engineering, Environmental
SC Engineering
GA 150DK
UT WOS:000319370200006
ER
PT J
AU Voloshinov, VB
Knyazev, GA
Kulakova, LA
Gupta, N
AF Voloshinov, V. B.
Knyazev, G. A.
Kulakova, L. A.
Gupta, N.
TI Acousto-optic control of light beams in the infrared range
SO PHYSICS OF WAVE PHENOMENA
LA English
DT Article
ID CRYSTALS; HG2CL2
AB The control over the parameters of the far-infrared and terahertz radiation by the acoustooptic method is discussed. The operation of a tunable acousto-optic filter based on the tellurium crystal is investigated. The crystal used in the filter was transparent for the optic radiation in the wavelength range of 4.0 to 23 A mu m. The device allows electronic tuning and processing of optic images in the spectral interval of 8.0 to 14 A mu m.
C1 [Voloshinov, V. B.; Knyazev, G. A.] Moscow MV Lomonosov State Univ, Fac Phys, Moscow 119991, Russia.
[Kulakova, L. A.] AF Ioffe Phys Tech Inst, St Petersburg 194021, Russia.
[Gupta, N.] USA, Res Lab, Adelphi, MD 20783 USA.
RP Voloshinov, VB (reprint author), Moscow MV Lomonosov State Univ, Fac Phys, Leninskie Gory 1-2, Moscow 119991, Russia.
EM volosh@phys.msu.ru; g_knyazev@mail.ru; L.Kulakova@mail.ioffe.ru;
neelam.gupta.civ@mail.mil
FU RFBR [12-02-01119-a, 11-02-00681-a, 10-07-00683, 10-07-00623]; CRDF [RUP
1-1663-MO-06]
FX The work was supported by RFBR Projects 12-02-01119-a, 11-02-00681-a,
10-07-00683, and 10-07-00623, and by the CRDF Grant RUP 1-1663-MO-06.
NR 12
TC 1
Z9 1
U1 0
U2 5
PU ALLERTON PRESS INC
PI NEW YORK
PA 18 WEST 27TH ST, NEW YORK, NY 10001 USA
SN 1541-308X
J9 PHYS WAVE PHENOM
JI Phys. Wave Phenom.
PD APR
PY 2013
VL 21
IS 2
BP 134
EP 138
DI 10.3103/S1541308X13020052
PG 5
WC Physics, Multidisciplinary
SC Physics
GA 151PH
UT WOS:000319472100005
ER
PT J
AU Datta, A
Yeo, H
Norman, TR
AF Datta, Anubhav
Yeo, Hyeonsoo
Norman, Thomas R.
TI Experimental Investigation and Fundamental Understanding of a Full-Scale
Slowed Rotor at High Advance Ratios
SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY
LA English
DT Article
ID COMPOUND HELICOPTER; TECHNOLOGY
AB This paper describes and analyzes the measurements from a full-scale, slowed revolutions per minute (rpm), UH-60A rotor tested at the National Full-Scale Aerodynamics Complex 40- by 80-ft wind tunnel up to an advance ratio of 1.0. A comprehensive set of measurements that includes performance, blade loads, hub loads, and pressures/airloads makes this data set unique. The measurements reveal new and rich aeromechanical phenomena that are unique to this exotic regime. These include reverse chord dynamic stall, retreating side impulse in torsion load, large inboard outboard elastic twist differential, diminishing rotor forces and yet a dramatic buildup of blade loads, and high blade loads and yet benign levels of vibratory hub loads. The objective of this research is the fundamental understanding of these unique aeromechanical phenomena. The intent is to provide useful knowledge for the design of high-speed, high-efficiency, slowed rpm rotors of the future and a database for validation of advanced analyses.
C1 [Datta, Anubhav] NASA, Ames Res Ctr, Sci & Technol Corp, USA,Aeroflightdynam Directorate, Moffett Field, CA 94035 USA.
[Yeo, Hyeonsoo] NASA, Ames Res Ctr, Aeroflightdynam Directorate AMRDEC, USA,Res Dev & Engn Command, Moffett Field, CA 94035 USA.
[Norman, Thomas R.] NASA, Ames Res Ctr, Aeromech Branch, Moffett Field, CA 94035 USA.
RP Datta, A (reprint author), NASA, Ames Res Ctr, Sci & Technol Corp, USA,Aeroflightdynam Directorate, Moffett Field, CA 94035 USA.
EM hubloads@gmail.com
NR 39
TC 10
Z9 10
U1 0
U2 7
PU AMER HELICOPTER SOC INC
PI ALEXANDRIA
PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA
SN 0002-8711
J9 J AM HELICOPTER SOC
JI J. Am. Helicopter Soc.
PD APR
PY 2013
VL 58
IS 2
AR 022004
DI 10.4050/JAHS.58.022004
PG 17
WC Engineering, Aerospace
SC Engineering
GA 147NF
UT WOS:000319173600004
ER
PT J
AU Yeo, H
Romander, EA
AF Yeo, Hyeonsoo
Romander, Ethan A.
TI Loads Correlation of a Full-Scale UH-60A Air loads Rotor in a Wind
Tunnel
SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY
LA English
DT Article
ID COMPREHENSIVE ANALYSIS; HELICOPTER ROTORS; AIRLOADS; PERFORMANCE;
PREDICTION; SYSTEM
AB Wind tunnel measurements of the rotor trim, blade airloads, and structural loads of a full-scale UH-60A Black Hawk main rotor are compared with calculations obtained using the comprehensive rotorcraft analysis CAMRAD II and a coupled CAMRAD II/OVERFLOW 2 analysis. A speed sweep at constant lift up to an advance ratio of 0.4 and a thrust sweep at constant speed into deep stall are investigated. The coupled analysis shows significant improvement over comprehensive analysis. Normal force phase is better captured for all the test conditions examined. Pitching moment is better predicted, including the magnitude and phase of the two stall events in the fourth quadrant at the deeply stalled condition. Structural loads are, in general, improved with the coupled analysis, but the magnitude of chord bending moment is still significantly underpredicted. As there are three modes around 4 and 5/rev frequencies, the structural responses to the 5/rev airloads due to dynamic stall are magnified and thus accurate analysis of the deeply stalled condition is challenging.
C1 [Yeo, Hyeonsoo] NASA, Ames Res Ctr, Aeroflightdynam Directorate AMRDEC, USA,Res Dev & Engn Command, Moffett Field, CA 94035 USA.
[Romander, Ethan A.] NASA, Ames Res Ctr, Flight Vehicle Res & Technol Div, Moffett Field, CA 94035 USA.
RP Yeo, H (reprint author), NASA, Ames Res Ctr, Aeroflightdynam Directorate AMRDEC, USA,Res Dev & Engn Command, Moffett Field, CA 94035 USA.
EM hyeonsoo.yeo.civ@mail.mil
NR 20
TC 1
Z9 1
U1 0
U2 3
PU AMER HELICOPTER SOC INC
PI ALEXANDRIA
PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA
SN 0002-8711
J9 J AM HELICOPTER SOC
JI J. Am. Helicopter Soc.
PD APR
PY 2013
VL 58
IS 2
DI 10.4050/JAHS.58.022003
PG 18
WC Engineering, Aerospace
SC Engineering
GA 147NF
UT WOS:000319173600003
ER
PT J
AU Cohen, RL
Li, YZ
Giese, R
Mancuso, JD
AF Cohen, Robert L.
Li, Yuanzhang
Giese, Russell
Mancuso, James D.
TI An Evaluation of the President's Emergency Plan for AIDS Relief Effect
on Health Systems Strengthening in Sub-Saharan Africa
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Article
DE PEPFAR; health systems strengthening; TB; child mortality; infant
mortality; life expectancy
ID TUBERCULOSIS; INITIATIVES; TRENDS; BURDEN
AB Background: President's Emergency Plan for AIDS Relief (PEPFAR) has been criticized for its vertical or "stove-piping" structure, with resources targeting a specific disease rather than working to strengthen the underlying health system. This study aimed to evaluate whether PEPFAR activities were associated with system-wide improvements in both proximal and distal indicators of health systems strengthening.
Methods: The World Bank database provided 12 indicators of health systems strengthening that were analyzed for their relationship to PEPFAR. Poisson and linear regression models were used to estimate the time trend. We evaluated the PEPFAR impact on health outcomes by comparing the time trend in each of the above indicators between 2 time periods: from 1995 to 2002 (pre-PEPFAR) and from 2004 to 2010 (during PEPFAR).
Results: PEPFAR activities showed strong and statistically significant associations with improvements in proximal indicators of health systems strengthening, those related directly to HIV, specifically life expectancy (P = 0.003) and tuberculosis incidence, prevalence, and mortality (P < 0.0001). There were nonsignificant associations between PEPFAR and improvements in distal indicators of health systems strengthening, namely infant mortality and under 5 child mortality.
Conclusions: The progressive scale-up of PEPFAR-supported activities was associated with consistent improvements in proximal indicators of health systems strengthening. It was also associated with improvements in broader measures of health system strength, most clearly life expectancy. Given the limited number of health measures available for this type of analysis, more data must be collected for other indicators to evaluate the effectiveness of the many multibillion dollar global health initiatives.
C1 [Cohen, Robert L.; Li, Yuanzhang; Mancuso, James D.] Walter Reed Army Inst Res, Prevent Med Program, Silver Spring, MD 20910 USA.
[Giese, Russell] Walter Reed Army Inst Res, Mil HIV Res Program, Silver Spring, MD 20910 USA.
RP Mancuso, JD (reprint author), Walter Reed Army Inst Res, Prevent Med Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM james.mancuso@us.army.mil
OI Li, Yuanzhang/0000-0001-8872-4430
FU US Department of Defense via the Walter Reed Army Institute of Research
FX Funding was provided by the US Department of Defense via the Walter Reed
Army Institute of Research.
NR 33
TC 6
Z9 6
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1525-4135
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD APR 1
PY 2013
VL 62
IS 4
BP 471
EP 479
DI 10.1097/QAI.0b013e3182816a86
PG 9
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 145SM
UT WOS:000319037700020
PM 23254150
ER
PT J
AU Psotka, J
AF Psotka, Joseph
TI Educational Games and Virtual Reality as Disruptive Technologies
SO EDUCATIONAL TECHNOLOGY & SOCIETY
LA English
DT Article
DE Disruptive technology; Educational games; Virtual reality; Modules;
Assessment; Leadership
ID SCIENCE
AB New technologies often have the potential for disrupting existing established practices, but nowhere is this so pertinent as in education and training today. And yet, education has been glacially slow to adopt these changes in a large scale way, and innovations seem to be imposed mainly by students' and their changing social lifestyles than by policy. Will this change? Leadership is sorely needed. Education needs to become more modular and move out of the classroom into informal settings, homes, and especially the interne. Nationwide certifications based on these modules would permit technology to enter education more rapidly. Smaller nations may be more flexible in making these very disruptive changes.
C1 USA, Res Inst Behav & Social Sci, Rockville, MD 20854 USA.
RP Psotka, J (reprint author), USA, Res Inst Behav & Social Sci, 1436 Fallsmead Way, Rockville, MD 20854 USA.
EM Psotka@msn.com
NR 38
TC 9
Z9 10
U1 1
U2 21
PU IEEE COMPUTER SOC, LEARNING TECHNOLOGY TASK FORCE
PI PALMERSTON NORTH
PA BAG 11-222, MASSEY UNIVERSITY, PALMERSTON NORTH, NEW ZEALAND
SN 1436-4522
J9 EDUC TECHNOL SOC
JI Educ. Technol. Soc.
PD APR
PY 2013
VL 16
IS 2
BP 69
EP 80
PG 12
WC Education & Educational Research
SC Education & Educational Research
GA 142VO
UT WOS:000318825900007
ER
PT J
AU Docherty, A
Menyuk, CR
Cahill, JP
Okusaga, O
Zhou, WM
AF Docherty, Andrew
Menyuk, Curtis R.
Cahill, James P.
Okusaga, Olukayode
Zhou, Weimin
TI Rayleigh-Scattering-Induced RIN and Amplitude-to-Phase Conversion as a
Source of Length-Dependent Phase Noise in OEOs
SO IEEE PHOTONICS JOURNAL
LA English
DT Article
DE Optoelectronic oscillators (OEOs); flicker noise; optical scattering
noise
ID OPTOELECTRONIC MICROWAVE-OSCILLATORS; FREQUENCY; STABILITY
AB Optoelectronic oscillators (OEOs) are hybrid RF-photonic oscillators that promise to be environmentally robust frequency sources with very low phase noise. Recent experiments have shown that the excess flicker phase noise in these systems grows with the length of the optical fiber loop. In this paper, we detail a mechanism for this length-dependent flicker noise in which Rayleigh-scattering-induced amplitude noise in the optical fiber combines with amplitude-to-phase noise conversion in the nonlinear electronic components. We derive an analytic model of the loop noise that includes these effects and verify this model by comparing it to numerical calculations and experimental results.
C1 [Docherty, Andrew; Menyuk, Curtis R.] Univ Maryland Baltimore Cty, Baltimore, MD 21250 USA.
[Cahill, James P.; Okusaga, Olukayode; Zhou, Weimin] USA, Res Lab, Adelphi, MD 20783 USA.
RP Docherty, A (reprint author), Univ Maryland Baltimore Cty, Baltimore, MD 21250 USA.
EM docherty@gmail.com
NR 23
TC 7
Z9 7
U1 0
U2 17
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1943-0655
EI 1943-0647
J9 IEEE PHOTONICS J
JI IEEE Photonics J.
PD APR
PY 2013
VL 5
IS 2
AR 5500514
DI 10.1109/JPHOT.2013.2250940
PG 14
WC Engineering, Electrical & Electronic; Optics; Physics, Applied
SC Engineering; Optics; Physics
GA 139IC
UT WOS:000318574700049
ER
PT J
AU Griffith, J
West, C
AF Griffith, James
West, Courtney
TI Master Resilience Training and Its Relationship to Individual Well-Being
and Stress Buffering Among Army National Guard Soldiers
SO JOURNAL OF BEHAVIORAL HEALTH SERVICES & RESEARCH
LA English
DT Article
ID MENTAL-HEALTH PROBLEMS; SOCIAL SUPPORT; LIFE EVENTS; COMBAT; DEPLOYMENT;
IRAQ; AFGHANISTAN; DEPRESSION; SYMPTOMS; DISORDER
AB To better enable soldiers to adapt to stressors of military life, Master Resilience Training has been offered to soldiers since 2009. Few studies have examined whether the training achieves its intended effects. To fill this gap, resilience-trained Army National Guard soldiers and civilians (N = 611) completed online questionnaires about their resilience training experience (72% completion rate, N = 441). Respondents (92% or more) indicated the training was helpful and improved resilience competencies that enhanced coping with stressful circumstances. Respondents (97% or more) indicated that these competencies were subsequently used in their military and civilian jobs. A measure of resilience competencies was developed and showed self-reported changes largely pertained to increased self-awareness and strength of character, including improved optimism, mental agility, and connection with others. Self-reported change in resilience competencies was associated with fewer behavioral health symptoms, especially, for those reporting more current stressful events (known as the buffering effect). Findings are discussed in terms of resilience's potency of training, content of the training, and the need to elaborate on resilience's relationship to specific stressors.
C1 [Griffith, James; West, Courtney] USA, Natl Guard Bur, Soldier & Family Support Div, Arlington, VA USA.
RP Griffith, J (reprint author), USA, Natl Guard Bur, Soldier & Family Support Div, Arlington, VA USA.
EM james.e.griffith@us.army.mil
NR 64
TC 11
Z9 12
U1 2
U2 25
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1094-3412
J9 J BEHAV HEALTH SER R
JI J. Behav. Health Serv. Res.
PD APR
PY 2013
VL 40
IS 2
BP 140
EP 155
DI 10.1007/s11414-013-9320-8
PG 16
WC Health Care Sciences & Services; Health Policy & Services; Public,
Environmental & Occupational Health
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health
GA 138ON
UT WOS:000318518100002
PM 23494766
ER
PT J
AU Zhong, XL
Mukhopadhyay, S
Gowtham, S
Pandey, R
Karna, SP
AF Zhong, Xiaoliang
Mukhopadhyay, Saikat
Gowtham, S.
Pandey, Ravindra
Karna, Shashi P.
TI Applicability of carbon and boron nitride nanotubes as biosensors:
Effect of biomolecular adsorption on the transport properties of carbon
and boron nitride nanotubes
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID ELECTRONIC TRANSPORT; DNA; HYBRIDIZATION; TRANSISTORS;
FUNCTIONALIZATION; ORIENTATION; SIMULATION; MOLECULES
AB The effect of molecular adsorption on the transport properties of single walled carbon and boron nitride nanotubes (CNTs and BNNTs) is investigated using density functional theory and non-equilibrium Green's function methods. The calculated I-V characteristics predict noticeable changes in the conductivity of semiconducting BNNTs due to physisorption of nucleic acid base molecules. Specifically, guanine which binds to the side wall of BNNT significantly enhances its conductivity by introducing conduction channels near the Fermi energy of the bioconjugated system. For metallic CNTs, a large background current masks relatively small changes in current due to the biomolecular adsorption. The results therefore suggest the suitability of BNNTs for biosensing applications. (C) 2013 AIP Publishing LLC. [http://dx.doi.org/10.1063/1.4801442]
C1 [Zhong, Xiaoliang; Mukhopadhyay, Saikat; Gowtham, S.; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA.
[Karna, Shashi P.] USA, Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA.
RP Pandey, R (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA.
EM pandey@mtu.edu
RI Mukhopadhyay, Saikat/B-4402-2011; Zhong, Xiaoliang/B-2220-2012
FU Army Research Office [W911NF-09-1-0221]
FX Helpful discussions with Haiying He are acknowledged. The work at
Michigan Technological University was performed under support by the
Army Research Office through Contract No. W911NF-09-1-0221.
NR 39
TC 3
Z9 3
U1 1
U2 34
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0003-6951
EI 1077-3118
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD APR 1
PY 2013
VL 102
IS 13
AR 133705
DI 10.1063/1.4801442
PG 4
WC Physics, Applied
SC Physics
GA 121JT
UT WOS:000317240200089
ER
PT J
AU Lu, XCM
Mountney, A
Chen, ZY
Wei, G
Cao, Y
Leung, LY
Khatri, V
Cunningham, T
Tortella, FC
AF Lu, Xi-Chun May
Mountney, Andrea
Chen, Zhiyong
Wei, Guo
Cao, Ying
Leung, Lai Yee
Khatri, Vivek
Cunningham, Tracy
Tortella, Frank C.
TI Similarities and Differences of Acute Nonconvulsive Seizures and Other
Epileptic Activities following Penetrating and Ischemic Brain Injuries
in Rats
SO JOURNAL OF NEUROTRAUMA
LA English
DT Article
DE EEG rat; MCAO; NCS; PBBI
ID INTENSIVE-CARE-UNIT; FOCAL CEREBRAL-ISCHEMIA; PERIODIC EEG PATTERNS;
TRANSHEMISPHERIC DIASCHISIS; CLINICAL-SIGNIFICANCE; GLYPROMATE ANALOG;
CRITICALLY-ILL; DISCHARGES; MODEL; STROKE
AB The similarities and differences between acute nonconvulsive seizures (NCS) and other epileptic events, for example, periodic epileptiform discharges (PED) and intermittent rhythmic delta activities (IRDA), were characterized in rat models of penetrating and ischemic brain injuries. The NCS were spontaneously induced by either unilateral frontal penetrating ballistic-like brain injury (PBBI) or permanent middle cerebral artery occlusion (pMCAO), and were detected by continuous electroencephalogram (EEG) monitoring begun immediately after the injury and continued for 72 h or 24 h, respectively. Analysis of NCS profiles (incidence, frequency, duration, and time distribution) revealed a high NCS incidence in both injury models. The EEG waveform expressions of NCS and PED exhibited intrinsic variations that resembled human electrographic manifestations of post-traumatic and post-ischemic ictal and inter-ictal events, but these waveform variations were not distinguishable between the two types of brain injury. However, the NCS after pMCAO occurred more acutely and intensely (latency = 0.6 h, frequency = 25 episodes/rat) compared with the PBBI-induced NCS (latency = 24 h, frequency = 10 episodes/rat), such that the most salient features differentiating post-traumatic and post-ischemic NCS were the intensity and time distribution of the NCS profiles. After pMCAO, nearly 50% of the seizures occurred within the first 2 h of injury, whereas after PBBI, NCS occurred sporadically (0-5%/h) throughout the 72 h recording period. The PED were episodically associated with NCS. By contrast, the IRDA appeared to be independent of other epileptic events. This study provided comprehensive comparisons of post-traumatic and post-ischemic epileptic profiles. The identification of the similarities and differences across a broad spectrum of epileptic events may lead to differential strategies for post-traumatic and post-stroke seizure interventions.
C1 [Lu, Xi-Chun May; Mountney, Andrea; Chen, Zhiyong; Wei, Guo; Cao, Ying; Leung, Lai Yee; Khatri, Vivek; Cunningham, Tracy; Tortella, Frank C.] Walter Reed Army Inst Res, Branch Brain Trauma Neuroprotect & Neurorestorat, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA.
RP Lu, XCM (reprint author), Walter Reed Army Inst Res, Branch Brain Trauma Neuroprotect & Neurorestorat, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM may.lu@us.army.mil
RI Leung, Lai Yee/H-8204-2013
NR 43
TC 10
Z9 10
U1 0
U2 5
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
J9 J NEUROTRAUM
JI J. Neurotrauma
PD APR
PY 2013
VL 30
IS 7
BP 580
EP 590
DI 10.1089/neu.2012.2641
PG 11
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA 133PD
UT WOS:000318150300009
PM 23234254
ER
PT J
AU Chalermchai, T
Valcour, V
Sithinamsuwan, P
Pinyakorn, S
Clifford, D
Paul, RH
Tipsuk, S
Fletcher, JLK
DeGruttola, V
Ratto-Kim, S
Hutchings, N
Shikuma, C
Ananworanich, J
AF Chalermchai, Thep
Valcour, Victor
Sithinamsuwan, Pasiri
Pinyakorn, Suteeraporn
Clifford, David
Paul, Robert H.
Tipsuk, Somporn
Fletcher, James L. K.
DeGruttola, Victor
Ratto-Kim, Silvia
Hutchings, Nicholas
Shikuma, Cecilia
Ananworanich, Jintanat
CA SEARCH 007 Study Grp
SEARCH 011 Study Grp
TI Trail Making Test A improves performance characteristics of the
International HIV Dementia Scale to identify symptomatic HAND
SO JOURNAL OF NEUROVIROLOGY
LA English
DT Article
DE HIV dementia; Neuropsychology; Asia; Neuropsychological tests; Trail
Making Test
ID RAPID SCREENING-TEST; NEUROCOGNITIVE DISORDERS; ANTIRETROVIRAL THERAPY;
INFECTED ADULTS; IMPAIRMENT; POPULATION; DISEASE; AIDS
AB Although HIV-associated dementia (HAD) occurs in less than 5 % of individuals with access to combination antiretroviral therapy, rates of milder forms of HIV-associated neurocognitive disorder (HAND) are much higher. We sought to define an optimal cut point for the International HIV Dementia Scale (IHDS) in Thailand for the identification of symptomatic HAND, defined as both HAD and mild neurocognitive disorder. We then sought to determine if adding a simple test from a larger neuropsychological battery could improve the performance characteristics for identifying symptomatic HAND. In this study, subjects comprising 75 seropositive adults in Bangkok, Thailand, completed neuropsychological tests and underwent a full neurological assessment. HAND diagnoses were determined by consensus conference using the 2007 Frascati criteria, blinded to the IHDS results. The optimal IHDS cut point was determined by receiver operating characteristic analysis with cross-validation. Individual neuropsychological tests were then evaluated and combined with the IHDS to test performance characteristics. The IHDS was poor at detecting symptomatic HAND at the optimized cut point of a parts per thousand currency sign10 (sensitivity, 53.3 %; specificity, 89.8 %). Trail Making Test A was most effective in improving performance characteristics when combined with the IHDS, with net sensitivity of 86 % and specificity of 79 %. In this setting, the IHDS performed poorly in identifying symptomatic HAND, but was substantially improved by the addition of Trail Making Test A, which typically requires less than 2 min to complete. This combination should be validated in a larger setting since it may address the critical need for HAND screening instruments in international settings.
C1 [Chalermchai, Thep; Tipsuk, Somporn; Fletcher, James L. K.; Ananworanich, Jintanat] Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand.
[Valcour, Victor; Hutchings, Nicholas] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94158 USA.
[Valcour, Victor] Univ Calif San Francisco, Dept Med, Div Geriatr Med, San Francisco, CA 94158 USA.
[Sithinamsuwan, Pasiri] Phramongkutklao Hosp, Bangkok, Thailand.
[Pinyakorn, Suteeraporn; Ananworanich, Jintanat] Thai Red Cross AIDS Res Ctr, HIV NAT, Bangkok, Thailand.
[Clifford, David] Washington Univ, Dept Neurol, St Louis, MO USA.
[Paul, Robert H.] Univ Missouri, Dept Psychol, St Louis, MO 63121 USA.
[DeGruttola, Victor] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA.
[Ananworanich, Jintanat] Chulalongkorn Univ, Fac Med, Bangkok 10330, Thailand.
[Ratto-Kim, Silvia] Walter Reed Army Inst Res, Mil HIV Res Program, Silver Spring, MD USA.
[Shikuma, Cecilia] Univ Hawaii Manoa, Hawaii Ctr AIDS, Honolulu, HI 96822 USA.
RP Valcour, V (reprint author), Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, 675 Nelson Rising Lane,MC 1207, San Francisco, CA 94158 USA.
EM vvalcour@memory.ucsf.edu
FU NIH [R01-NS053359, R01-NS061696]
FX This work was supported by NIH grants R01-NS053359 (SR) and R01-NS061696
(VV). We thank the study subjects for their participation and Nicholas
Hutchings for assistance with the manuscript.
NR 46
TC 8
Z9 8
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1355-0284
EI 1538-2443
J9 J NEUROVIROL
JI J. Neurovirol.
PD APR
PY 2013
VL 19
IS 2
BP 137
EP 143
DI 10.1007/s13365-013-0151-4
PG 7
WC Neurosciences; Virology
SC Neurosciences & Neurology; Virology
GA 138NJ
UT WOS:000318515000005
PM 23483520
ER
PT J
AU Zubko, E
Muinonen, K
Shkuratov, Y
Videen, G
AF Zubko, Evgenij
Muinonen, Karri
Shkuratov, Yuriy
Videen, Gorden
TI Characteristics of cometary dust in the innermost coma derived from
polarimetry by Giotto
SO MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
LA English
DT Article
DE comets: individual: 1P/Halley; comets: individual: 26P/Grigg-Skjellerup;
comets: individual: 81P/Wild 2
ID DISCRETE-DIPOLE APPROXIMATION; GAUSSIAN RANDOM PARTICLES;
LIGHT-SCATTERING; OPTICAL-CONSTANTS; GRIGG-SKJELLERUP; 81P/WILD-2 DUST;
HALLEY DUST; POLARIZATION; SIMULATIONS; SPACECRAFT
AB We interpret the polarimetric measurements of Comets 1P/Halley and 26P/Grigg-Skjellerup carried out by the Giotto space probe using light-scattering properties of model agglomerate particles having different structures and compositions. Our simulations suggest that the overall low linear polarization registered in the innermost coma can be interpreted in terms of a high abundance of Mg-rich silicate particles and depletion of carbonaceous materials. Variation of the polarization throughout the innermost coma could be explained either through a significant variation in the size distribution or through a slight variation of refractive index of cometary dust, whereas even a considerable difference in the morphology of agglomerate particles has a weak impact on the linear polarization.
C1 [Zubko, Evgenij; Muinonen, Karri] Univ Helsinki, Dept Phys, FI-00014 Helsinki, Finland.
[Zubko, Evgenij; Shkuratov, Yuriy] Kharkov Natl Univ, Inst Astron, UA-61022 Kharkov, Ukraine.
[Muinonen, Karri] Finnish Geodet Inst, FI-02431 Masala, Finland.
[Videen, Gorden] Space Sci Inst, Boulder, CO 80301 USA.
[Videen, Gorden] USA, Res Lab, Adelphi, MD 20783 USA.
RP Zubko, E (reprint author), Univ Helsinki, Dept Phys, POB 64, FI-00014 Helsinki, Finland.
EM Evgenij.Zubko@helsinki.fi
FU Academy of Finland [127461]; NASA program for Outer Planets Research
[NNX10AP93G]
FX This work was partially supported by the Academy of Finland (contract
127461) and by NASA program for Outer Planets Research (grant
NNX10AP93G). We are grateful to Prof. A. Ch. Levasseur-Regourd for
valuable comments on this paper.
NR 35
TC 8
Z9 8
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0035-8711
J9 MON NOT R ASTRON SOC
JI Mon. Not. Roy. Astron. Soc.
PD APR
PY 2013
VL 430
IS 2
BP 1118
EP 1124
DI 10.1093/mnras/sts679
PG 7
WC Astronomy & Astrophysics
SC Astronomy & Astrophysics
GA 135FY
UT WOS:000318275000030
ER
PT J
AU Seay, JF
Ely, BR
Kenefick, RW
Sauer, SG
Cheuvront, SN
AF Seay, Joseph F.
Ely, Brett R.
Kenefick, Robert W.
Sauer, Shane G.
Cheuvront, Samuel N.
TI Hypohydration Does Not Alter Standing Balance
SO MOTOR CONTROL
LA English
DT Article
DE dehydration; center of pressure; sway path; sway velocity; plasma
volume; plasma osmolality
ID POSTURAL STABILITY; HEAT-STRESS; COLD-AIR; DEHYDRATION; EXERCISE;
PERFORMANCE; BLOOD; RESPONSES; FATIGUE; HYDRATION
AB We examined the effect of body water deficits on standing balance and sought to determine if plasma hyperosmolality (P-osm) and/or volume reduction (%Delta V-plasma) exerted independent effects. Nine healthy volunteers completed three experimental trials which consisted of a euhydration (EUH) balance test, a water deficit session and a hypohydration (HYP) balance test. Hypohydration was achieved both by exercise-heat stress to 3% and 5% body mass loss (BML), and by a diuretic to 3% BML. Standing balance was assessed during quiet standing on a force platform with eyes open and closed. With eyes closed, hypohydration significantly decreased medial-lateral sway path and velocity by 13% (both p < .040). However, 95% confidence intervals for the mean difference between EUH and HYP were all within the coefficient of variation of EUH measures, indicating limited practical importance. Neither V-plasma loss nor P-osm increases were associated with changes in balance. We concluded that standing balance was not altered by hypohydration.
C1 [Seay, Joseph F.; Ely, Brett R.; Kenefick, Robert W.; Sauer, Shane G.; Cheuvront, Samuel N.] USA, Environm Med Res Inst, Natick, MA 01760 USA.
RP Seay, JF (reprint author), USA, Environm Med Res Inst, Natick, MA 01760 USA.
NR 40
TC 2
Z9 2
U1 0
U2 6
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 1087-1640
J9 MOTOR CONTROL
JI Motor Control
PD APR
PY 2013
VL 17
IS 2
BP 190
EP 202
PG 13
WC Neurosciences; Sport Sciences
SC Neurosciences & Neurology; Sport Sciences
GA 139KE
UT WOS:000318580800005
PM 23155117
ER
PT J
AU Hong, SS
Yheulon, CG
Sniezek, JC
AF Hong, Steven S.
Yheulon, Christopher G.
Sniezek, Joseph C.
TI Salivary Gland Surgery and Medical Malpractice
SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY
LA English
DT Article; Proceedings Paper
CT AAO-HNSF Annual Meeting and OTO EXPO
CY SEP 09-12, 2012
CL Washington, DC
SP AAO, HNSF, Off Res & Dev, Vet Hlth Adm, Dept Vet Affairs, MED-EL, Agcy Healthcare Res & Qual, Sect Residents & Fellows Training
DE salivary gland; parotid gland; submandibular gland; malpractice; legal;
lawsuit; facial nerve monitor; facial nerve; lingual nerve; informed
consent
ID FACIAL-NERVE SCHWANNOMA; PARALYSIS; PAROTIDECTOMY; EXPERIENCE;
MANAGEMENT
AB Objective. To better understand the causes and outcomes of lawsuits involving salivary gland surgery by analyzing malpractice litigation trends to prevent future litigation and improve physician education.
Study Design. Analysis of a national database.
Setting. All US civil trials.
Subjects and Methods. The WESTLAW database was reviewed from January 1987 to March 2011. Data were compiled on the demographics of the defendant, anatomic site of injury, initial pathology, nature of injury, legal allegations, verdicts, and indemnities.
Results. Twenty-six cases met inclusion criteria and were selected for review. Verdicts/settlements for the plaintiffs predominated (58%), and the average sum of the plaintiff's monetary award was $933,235. Sixteen cases (62%) involved injury to the parotid gland/duct, with 10 cases involving injury to the facial nerve. No cases were filed on the grounds of failure to use facial nerve monitoring. Nine cases (35%) involved injury to the submandibular gland/duct. The most common legal allegations listed were improper performance followed by unnecessary procedures. If failure or inadequate consent was a component of the legal allegations, the verdict outcome significantly favored the defendants.
Conclusion. Our study reveals that the plaintiffs in litigations involving salivary gland surgery have a slight advantage in outcomes with a fairly substantial award. Our litigation review reiterates the importance of detailed anatomic knowledge of the lingual and facial nerve to avoid the pitfalls of surgical error and consequent litigation. In addition, thorough preoperative evaluation of salivary gland pathology, including radiographic studies and needle biopsy, may help avoid errors in diagnosis and subsequent litigations.
C1 [Hong, Steven S.; Yheulon, Christopher G.; Sniezek, Joseph C.] Tripler Army Med Ctr, Dept Otolaryngol, Honolulu, HI 96859 USA.
RP Hong, SS (reprint author), Tripler Army Med Ctr, Dept Otolaryngol, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM shongmd@gmail.com
NR 23
TC 17
Z9 17
U1 0
U2 3
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0194-5998
J9 OTOLARYNG HEAD NECK
JI Otolaryngol. Head Neck Surg.
PD APR
PY 2013
VL 148
IS 4
BP 589
EP 594
DI 10.1177/0194599813475566
PG 6
WC Otorhinolaryngology; Surgery
SC Otorhinolaryngology; Surgery
GA 136LG
UT WOS:000318362800011
PM 23380759
ER
PT J
AU Liu, YH
Xu, YH
Zhu, YJ
Culver, JN
Lundgren, CA
Xu, K
Wang, CS
AF Liu, Yihang
Xu, Yunhua
Zhu, Yujie
Culver, James N.
Lundgren, Cynthia A.
Xu, Kang
Wang, Chunsheng
TI Tin-Coated Viral Nanoforests as Sodium-Ion Battery Anodes
SO ACS NANO
LA English
DT Article
DE Na-ion batteries; Sn nanoforest anodes; nanohierarchy; tobacco mosaic
virus; physical vapor deposition; magnetron sputtering
ID LITHIUM SECONDARY BATTERIES; RECHARGEABLE NA BATTERIES; HIGH-CAPACITY;
ELECTRODE MATERIAL; HOLLOW CARBON; ELECTROCHEMICAL PROPERTIES;
THIN-FILM; SN; INSERTION; PERFORMANCE
AB Designed as a high-capacity alloy host for Na-ion chemistry, a forest of 5n nanorods with a unique core-shell structure was synthesized on viral scaffolds, which were genetically engineered to ensure a nearly vertical alignment upon self-assembly onto a metal substrate. The interdigital spaces thus formed between individual rods effectively accommodated the volume expansion and contraction of the alloy upon sodiation/desodiation, while additional carbon-coating engineered over these nanorods further suppressed Sn aggregation during extended electrochemical cycling. Due to the unique nanohierarchy of multiple functional layers, the resultant 3D nanoforest of C/Sn/Ni/TMV1cys, binder-free composite electrode already and evenly assembled on a stainless steel current collector, exhibited supreme capacity utilization and cycling stability toward Na-ion storage and release. An initial capacity of 722 mA.h (g Sn)(-1) along with 405 mA.h (g Sn)(-1) retained after 150 deep cycles demonstrates the longest-cycling nano-Sn anode material for Na-ion batteries reported in the literature to date and marks a significant performance improvement for neat Sn material as alloy host for Na-ion chemistry.
C1 [Liu, Yihang; Xu, Yunhua; Zhu, Yujie; Wang, Chunsheng] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA.
[Culver, James N.] Univ Maryland, Inst Biosci & Biotechnol Res, College Pk, MD 20742 USA.
[Culver, James N.] Univ Maryland, Dept Plant Sci & Landscape Architecture, College Pk, MD 20742 USA.
[Lundgren, Cynthia A.; Xu, Kang] USA, Electrochem Branch, Res Lab, Adelphi, MD 20783 USA.
RP Xu, K (reprint author), USA, Electrochem Branch, Res Lab, Adelphi, MD 20783 USA.
EM conrad.k.xu.civ@mail.mil; cswang@umd.edu
RI Wang, Chunsheng/H-5767-2011; Xu, Yunhua/D-7751-2012; Liu,
Yihang/E-6958-2013
OI Wang, Chunsheng/0000-0002-8626-6381; Liu, Yihang/0000-0002-2491-9439
FU U.S. Army Research Laboratory; Nanostructures for Electrical Energy
Storage, an Energy Frontier Research Center; U.S. Department of Energy,
Office of Science, Office of Basic Energy Sciences [DESC0001160]
FX The authors acknowledge financial support from the U.S. Army Research
Laboratory and the technical support of the Maryland NanoCenter. We
thank Dr. Li-Chung Lai for the TEM imaging, John Abrahams for the
deposition, and Yanmei Piao for collecting the Raman data. Y. Liu was
partially supported as part of the Nanostructures for Electrical Energy
Storage, an Energy Frontier Research Center funded by the U.S.
Department of Energy, Office of Science, Office of Basic Energy Sciences
under Award Number DESC0001160.
NR 54
TC 124
Z9 127
U1 41
U2 434
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1936-0851
J9 ACS NANO
JI ACS Nano
PD APR
PY 2013
VL 7
IS 4
BP 3627
EP 3634
DI 10.1021/nn400601y
PG 8
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA 133MU
UT WOS:000318143300079
PM 23484633
ER
PT J
AU Margolis, LM
Rood, J
Champagne, C
Young, AJ
Castellani, JW
AF Margolis, Lee M.
Rood, Jennifer
Champagne, Catherine
Young, Andrew J.
Castellani, John W.
TI Energy balance and body composition during US Army special forces
training
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM-PHYSIOLOGIE APPLIQUEE
NUTRITION ET METABOLISME
LA English
DT Article
DE doubly labeled water; energy expenditure; energy intake; military
training
ID SUSTAINED EXERCISE; PHYSICAL-ACTIVITY; WATER MEASUREMENT; LABELED WATER;
FOOD-INTAKE; EXPENDITURE; MEN; PERFORMANCE; SOLDIERS; HUMANS
AB Small Unit Tactics (SUT) is a 64-day phase of the Special Forces Qualification Course designed to simulate real-world combat operations. Assessing the metabolic and physiological responses of such intense training allows greater insights into nutritional requirements of soldiers during combat. The purpose of this study was to examine energy balance around specific training events, as well as changes in body mass and composition. Data were collected from 4 groups of soldiers (n = 36) across 10-day periods. Participants were 28 +/- 5 years old, 177 +/- 6 cm tall, and weighed 83 +/- 7 kg. Doubly labeled water ((D2O)-O-18) was used to assess energy expenditure. Energy intake was calculated by subtracting energy in uneaten foods from known energy in distributed foods in individually packaged combat rations or in the dining facility. Body composition was estimated from skinfold thickness measurements on days 0 and 64 of the course. Simulated urban combat elicited that largest energy deficit (11.3 +/- 2.3 MJ.day(-1) (2700 +/- 550 kcal.day(-1)); p < 0.05), and reduction in body mass (3.3 +/- 1.9 kg; p < 0.05), during SUT, while energy balance was maintained during weapons familiarization training and platoon size raids. Over the entire course body mass decreased by 4.2 +/- 3.7 kg (p < 0.01), with fat mass decreasing by 2.8 +/- 2.0 kg (p < 0.01) and fat-free mass decreasing by 1.4 +/- 2.8 kg (p < 0.05). The overall reduction in body mass suggests that soldiers were in a negative energy balance during SUT, with high energy deficit being observed during strenuous field training.
C1 [Margolis, Lee M.; Young, Andrew J.; Castellani, John W.] USA, Environm Med Res Inst, Natick, MA 01760 USA.
[Rood, Jennifer; Champagne, Catherine] Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
RP Margolis, LM (reprint author), USA, Environm Med Res Inst, 42 Kansas St, Natick, MA 01760 USA.
EM lee.margolis@us.army.mil
OI , Lee/0000-0002-0652-1304
NR 33
TC 5
Z9 5
U1 0
U2 14
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 1200 MONTREAL ROAD, BUILDING M-55, OTTAWA, ON K1A 0R6, CANADA
SN 1715-5312
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD APR
PY 2013
VL 38
IS 4
BP 396
EP 400
DI 10.1139/apnm-2012-0323
PG 5
WC Nutrition & Dietetics; Physiology; Sport Sciences
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA 131AA
UT WOS:000317961300006
PM 23713532
ER
PT J
AU Webber, AF
Heath, JA
Fischer, RA
AF Webber, Alyson F.
Heath, Julie A.
Fischer, Richard A.
TI Human disturbance and stage-specific habitat requirements influence
snowy plover site occupancy during the breeding season
SO ECOLOGY AND EVOLUTION
LA English
DT Article
DE Beach; coastal engineering; multi-season occupancy models; nesting;
restoration; shorebird
ID CHARADRIUS-ALEXANDRINUS; THINORNIS-RUBRICOLLIS; REPRODUCTIVE SUCCESS;
FLEDGING SUCCESS; PIPING PLOVERS; NEST SUCCESS; NEW-YORK; SELECTION;
PREDATION; RESPONSES
AB Habitat use has important consequences for avian reproductive success and survival. In coastal areas with recreational activity, human disturbance may limit use of otherwise suitable habitat. Snowy plovers Charadrius nivosus have a patchy breeding distribution along the coastal areas on the Florida Panhandle, USA. Our goal was to determine the relative effects of seasonal human disturbance and habitat requirements on snowy plover habitat use. We surveyed 303 sites for snowy plovers, human disturbance, and habitat features between January and July 2009 and 2010. We made multiple visits during three different sampling periods that corresponded to snowy plover breeding: pre-breeding, incubation, and brood-rearing and used multi-season occupancy models to examine whether human disturbance, habitat features, or both influenced site occupancy, colonization (probability of transition from an unoccupied site to an occupied site), and extinction (probability of transition from an occupied site to an unoccupied site). Snowy plover site occupancy and colonization was negatively associated with human disturbance and site extinction was positively associated with human disturbance. Interdune vegetation had a negative effect on occupancy and colonization, indicating that plovers were less likely to use areas with uniform, dense vegetation among dunes. Also, dune shape, beach debris, and access to low-energy foraging areas influenced site occupancy, colonization, and extinction. Plovers used habitat based on beach characteristics that provided stage-specific resource needs; however, human disturbance was the strongest predictor of site occupancy. In addition, vegetation plantings used to enhance dune rehabilitation may negatively impact plover site occupancy. Management actions that decrease human disturbance, such as symbolic fencing and signage, may increase the amount of breeding habitat available to snowy plovers on the Florida Panhandle and in other areas with high human activity. The specific areas that require this protection may vary across snowy plover life history stages.
C1 [Webber, Alyson F.; Heath, Julie A.] Boise State Univ, Dept Biol Sci, Boise, ID 83725 USA.
[Fischer, Richard A.] USACE Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.
RP Webber, AF (reprint author), Boise State Univ, Dept Biol Sci, Boise, ID 83725 USA.
EM afwebber@gmail.com
RI Heath, Julie/D-5600-2011
OI Heath, Julie/0000-0002-9606-1689
FU U.S. Army Engineer Research and Development Center Boise State
University; U.S. Army Engineer Research and Development Center, Dredging
Operations and Environmental Research Program
FX U.S. Army Engineer Research and Development Center Boise State
University; We thank C. Lott, I. Robertson, and R. Pruner for advice in
designing this project. D. Bateman and M. Foster helped with data
collection. We thank: J. Bente, J. Zimmerman, A. Harvey, M. Cory-Ogden,
T. Tindall, M. Knapke, D. Schingler, and C. Keen with Florida State
Parks, R. Hoggart and M. Nicholas at Gulf Islands National Seashore, B.
Miller and K. Gault at Eglin Air Force Base, W. Jones at Tyndall Air
Force Base, P. Kelly and H. Mitchell at USFWS, J. Himes at Florida Fish
and Wildlife Conservation Commission. M. Currie of Walton County, T. Day
of Escambia County, and S. Smith of the Santa Rosa Island Authority for
logistical and permitting support. Thanks also to all the private land
owners who granted access for this study. This project was funded by
U.S. Army Engineer Research and Development Center, Dredging Operations
and Environmental Research Program.
NR 59
TC 14
Z9 15
U1 4
U2 61
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2045-7758
J9 ECOL EVOL
JI Ecol. Evol.
PD APR
PY 2013
VL 3
IS 4
BP 853
EP 863
DI 10.1002/ece3.511
PG 11
WC Ecology; Evolutionary Biology
SC Environmental Sciences & Ecology; Evolutionary Biology
GA 126FW
UT WOS:000317599300010
PM 23610630
ER
PT J
AU Palacios, G
Savji, N
da Rosa, AT
Desai, A
Sanchez-Seco, MP
Guzman, H
Lipkin, WI
Tesh, R
AF Palacios, Gustavo
Savji, Nazir
da Rosa, Amelia Travassos
Desai, Aaloki
Paz Sanchez-Seco, Maria
Guzman, Hilda
Lipkin, W. Ian
Tesh, Robert
TI Characterization of the Salehabad virus species complex of the genus
Phlebovirus (Bunyaviridae)
SO JOURNAL OF GENERAL VIROLOGY
LA English
DT Article
ID VALLEY FEVER VIRUS; HIDDEN MARKOV MODEL; COMPLETE GENOMES; GOLGI
RETENTION; TOSCANA-VIRUS; PROTEIN; PREDICTION; TOPOLOGY; SEQUENCE;
SOFTWARE
AB Genomic and antigenic characterization of the Salehabad virus, a species of the genus Phlebovirus, and four other unclassified phleboviruses (Arbia, Adria, Arumowot and Odrenisrou) demonstrate a serological and genetic relation to one another and are distinct from the, eight other recognized species within the genus Phlebovirus. We propose to incorporate these four unclassified viruses as part of the Salehabad species complex within the genus. The known geographical distribution for the members of this species group includes southern Europe, Central Asia and Africa.
C1 [Palacios, Gustavo] USA, Med Res Inst Infect Dis, Ctr Genom Sci, Frederick, MD 21702 USA.
[Palacios, Gustavo; Savji, Nazir; Desai, Aaloki; Lipkin, W. Ian] Columbia Univ, Ctr Infect & Immun, New York, NY USA.
[da Rosa, Amelia Travassos; Guzman, Hilda; Tesh, Robert] Univ Texas Med Branch, Dept Pathol, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 USA.
[Paz Sanchez-Seco, Maria] Inst Salud Carlos III, Natl Ctr Microbiol, Madrid, Spain.
RP Palacios, G (reprint author), USA, Med Res Inst Infect Dis, Ctr Genom Sci, Frederick, MD 21702 USA.
EM gustavo.f.palacios.ctr@us.army.mil
RI Palacios, Gustavo/I-7773-2015
OI Palacios, Gustavo/0000-0001-5062-1938
FU National Institutes of Health [AI57158]; USAID [07-301-7119-52258];
Department of Defense; NIH [HHSN2722010000ROI/HHSN27200004/DO4]
FX This work was supported by Google.org, National Institutes of Health
award AI57158 (North-east Biodefence Center - Lipkin), and USAID Predict
funding source code 07-301-7119-52258 (Center for Infection and
Immunity) and the Department of Defense. A. T. R., R. T. and H. G. were
supported by NIH contract HHSN2722010000ROI/HHSN27200004/DO4.
NR 36
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U1 0
U2 2
PU SOC GENERAL MICROBIOLOGY
PI READING
PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG,
BERKS, ENGLAND
SN 0022-1317
J9 J GEN VIROL
JI J. Gen. Virol.
PD APR
PY 2013
VL 94
BP 837
EP 842
DI 10.1099/vir.0.048850-0
PN 4
PG 6
WC Biotechnology & Applied Microbiology; Virology
SC Biotechnology & Applied Microbiology; Virology
GA 131LM
UT WOS:000317995200017
PM 23239568
ER
PT J
AU Kontos, AP
Kotwal, RS
Elbin, RJ
Lutz, RH
Forsten, RD
Benson, PJ
Guskiewicz, KM
AF Kontos, Anthony P.
Kotwal, Russ S.
Elbin, R. J.
Lutz, Robert H.
Forsten, Robert D.
Benson, Peter J.
Guskiewicz, Kevin M.
TI Residual Effects of Combat-Related Mild Traumatic Brain Injury
SO JOURNAL OF NEUROTRAUMA
LA English
DT Article
DE mTBI; PTSD; symptoms; military
ID PROFESSIONAL FOOTBALL PLAYERS; OPERATION-IRAQI-FREEDOM; MENTAL-HEALTH
PROBLEMS; RECURRENT CONCUSSION; HISTORY; AFGHANISTAN; COLLEGIATE;
SERVICE; RISK; CARE
AB Mild traumatic brain injury (mTBI) has gained considerable notoriety during the past decade of conflict in Afghanistan and Iraq. However, the relationship between combat-related mTBI and residual mTBI symptoms, post-traumatic stress disorder (PTSD) symptoms, and neurocognitive deficits remains unclear. The purpose of the study was to compare residual mTBI and PTSD symptoms, and neurocognitive deficits among U.S. Army Special Operations Command (USASOC) personnel with diagnosed blunt, blast, and blast-blunt combination mTBIs. This study involved a retrospective medical records review of 27,169 USASOC personnel who completed a military version of the Immediate Post-Concussion Assessment Cognitive Test (ImPACT), Post-Concussion Symptom Scale (PCSS), and PTSD Checklist (PCL) between November 2009 and December 2011. Of the 22,203 personnel who met criteria for the study, 2,813 (12.7%) had a diagnosis of at least one mTBI. A total of 28% (n = 410) of USASOC personnel with a history of diagnosed mTBI reported clinical levels of PTSD symptoms. Personnel with a history of diagnosed blunt (OR = 3.58), blast (OR = 4.23) or combination (OR = 5.73) mTBI were at significantly (p = 0.001) greater risk of reporting clinical levels of PTSD symptoms than those with no history of mTBI. A dose-response gradient for exposure to blast/combination mTBI on clinical levels of PTSD symptoms was also significant (p = 0.001). Individuals with blast/combination mTBIs scored higher in residual mTBI (p = 0.001) and PTSD symptoms (p = 0.001), and performed worse on tests of visual memory (p = 0.001), and reaction time (p = 0.001) than those with blunt or no mTBI history. Individuals with combination mTBIs scored lower in verbal memory (p = 0.02) than those with blunt mTBIs. Residual PTSD and mTBI symptoms appear to be more prevalent in personnel with blast mTBI. A dose-response gradient for blast mTBI and symptoms suggests that repeated exposures to these injuries may have lingering effects.
C1 [Kontos, Anthony P.; Elbin, R. J.] Univ Pittsburgh, Med Ctr, Sports Med Concuss Program, Pittsburgh, PA 15203 USA.
[Kotwal, Russ S.; Lutz, Robert H.; Forsten, Robert D.; Benson, Peter J.] USA, Special Operat Command, Ft Bragg, NC USA.
[Guskiewicz, Kevin M.] Univ N Carolina, Matthew Gfeller Sport Related Traumat Brain Injur, Chapel Hill, NC USA.
RP Kontos, AP (reprint author), Univ Pittsburgh, Sch Med, Dept Orthopaed Surg, UPMC Sports Med Concuss Program, 3200 South Water St, Pittsburgh, PA 15203 USA.
EM akontos@pitt.edu
OI Guskiewicz, Kevin/0000-0002-8682-2130
FU U.S. Special Operations Command Biomedical Initiatives Steering
Committee
FX This research was funded by the U.S. Special Operations Command
Biomedical Initiatives Steering Committee. The views expressed herein
are those of the author(s) and do not reflect the official policy of the
Department of the Army, Department of Defense, or the U.S. Government.
Citations of commercial products or organizations do not constitute an
official DoD endorsement or approval of the products or services of
these organizations. This report was approved for public release by the
U.S. Army Special Operations Command Operational Security Office and
Public Affairs Office on March 27, 2012, and the U.S. Army Medical
Department Public Affairs Office on March 27, 2012.
NR 31
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U2 27
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
J9 J NEUROTRAUM
JI J. Neurotrauma
PD APR
PY 2013
VL 30
IS 8
SI SI
BP 680
EP 686
DI 10.1089/neu.2012.2506
PG 7
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA 133PO
UT WOS:000318151500010
PM 23031200
ER
PT J
AU Grant, KW
Walden, BE
Summers, V
Leek, MR
AF Grant, Ken W.
Walden, Brian E.
Summers, Van
Leek, Marjorie R.
TI Auditory Models of Suprathreshold Distortion in Persons with Impaired
Hearing Introduction
SO JOURNAL OF THE AMERICAN ACADEMY OF AUDIOLOGY
LA English
DT Editorial Material
ID SPEECH-RECEPTION THRESHOLD; NOISE; AID; LISTENERS; COGNITION; BENEFIT
C1 [Grant, Ken W.; Summers, Van] Walter Reed Natl Mil Med Ctr, Sci & Clin Studies Sect, Audiol & Speech Ctr, Bethesda, MD USA.
[Walden, Brian E.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
[Leek, Marjorie R.] Portland VA Med Ctr, VA RR&D Natl Ctr Rehabil Auditory Res, Portland, OR USA.
RP Grant, KW (reprint author), Walter Reed Natl Mil Med Ctr, Sci & Clin Studies Sect, Audiol & Speech Ctr, Bethesda, MD USA.
NR 24
TC 3
Z9 3
U1 0
U2 2
PU AMER ACAD AUDIOLOGY
PI RESTON
PA 11730 PLAZA DR, STE 300, RESTON, VA 20190 USA
SN 1050-0545
J9 J AM ACAD AUDIOL
JI J. Am. Acad. Audiol.
PD APR
PY 2013
VL 24
IS 4
BP 254
EP 257
DI 10.3766/jaaa.24.4.2
PG 4
WC Audiology & Speech-Language Pathology; Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Otorhinolaryngology
GA 134JK
UT WOS:000318206300002
PM 23636207
ER
PT J
AU Malhotra, S
Yen, JY
Honko, AN
Garamszegi, S
Caballero, IS
Johnson, JC
Mucker, EM
Trefry, JC
Hensley, LE
Connor, JH
AF Malhotra, Shikha
Yen, Judy Y.
Honko, Anna N.
Garamszegi, Sara
Caballero, Ignacio S.
Johnson, Joshua C.
Mucker, Eric M.
Trefry, John C.
Hensley, Lisa E.
Connor, John H.
TI Transcriptional Profiling of the Circulating Immune Response to Lassa
Virus in an Aerosol Model of Exposure
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID EBOLA HEMORRHAGIC-FEVER; CD8 T-CELLS; MASTOMYS-NATALENSIS; CYNOMOLGUS
MONKEYS; DENDRITIC CELLS; GUINEA-PIGS; NONHUMAN-PRIMATES;
GENE-EXPRESSION; SIERRA-LEONE; INFECTION
AB Lassa virus (LASV) is a significant human pathogen that is endemic to several countries in West Africa. Infection with LASV leads to the development of hemorrhagic fever in a significant number of cases, and it is estimated that thousands die each year from the disease. Little is known about the complex immune mechanisms governing the response to LASV or the genetic determinants of susceptibility and resistance to infection. In the study presented here, we have used a whole-genome, microarray-based approach to determine the temporal host response in the peripheral blood mononuclear cells (PBMCs) of non-human primates (NHP) following aerosol exposure to LASV. Sequential sampling over the entire disease course showed that there are strong transcriptional changes of the immune response to LASV exposure, including the early induction of interferon-responsive genes and Toll-like receptor signaling pathways. However, this increase in early innate responses was coupled with a lack of pro-inflammatory cytokine response in LASV exposed NHPs. There was a distinct lack of cytokines such as IL1 beta and IL23 alpha, while immunosuppressive cytokines such as IL27 and IL6 were upregulated. Comparison of IRF/STAT1-stimulated gene expression with the viral load in LASV exposed NHPs suggests that mRNA expression significantly precedes viremia, and thus might be used for early diagnostics of the disease. Our results provide a transcriptomic survey of the circulating immune response to hemorrhagic LASV exposure and provide a foundation for biomarker identification to allow clinical diagnosis of LASV infection through analysis of the host response.
C1 [Malhotra, Shikha; Yen, Judy Y.; Garamszegi, Sara; Caballero, Ignacio S.; Connor, John H.] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA.
[Honko, Anna N.; Johnson, Joshua C.; Mucker, Eric M.; Trefry, John C.; Hensley, Lisa E.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Garamszegi, Sara; Caballero, Ignacio S.; Connor, John H.] Boston Univ, Grad Program Bioinformat, Boston, MA 02215 USA.
[Hensley, Lisa E.] NIAID, Integrated Res Facil Ft Detrick, Div Clin Res, NIH, Frederick, MD USA.
RP Malhotra, S (reprint author), Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA.
EM jhconnor@bu.edu
OI Johnson, Joshua/0000-0002-5677-3841; Connor, John/0000-0002-8867-7256;
Honko, Anna/0000-0001-9165-148X
FU Joint Science and Technology Office for Chemical and Biological Defense;
Defense Threat Reduction Agency [JSTO-CBD 4.0021.08.RD.B]; NSF Graduate
Research Fellowships Program; Fulbright Commission Spain; Regional
Government of Andalusia
FX This research was supported by a grant through the Joint Science and
Technology Office for Chemical and Biological Defense and the Defense
Threat Reduction Agency (JSTO-CBD 4.0021.08.RD.B). SG was supported by
the NSF Graduate Research Fellowships Program. ISC was supported by the
Fulbright Commission Spain and the Regional Government of Andalusia. The
funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
NR 58
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U1 0
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1935-2735
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD APR
PY 2013
VL 7
IS 4
AR e2171
DI 10.1371/journal.pntd.0002171
PG 13
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 133QC
UT WOS:000318153100025
PM 23638192
ER
PT J
AU Reed, C
Lin, K
Wilhelmsen, C
Friedrich, B
Nalca, A
Keeney, A
Donnelly, G
Shamblin, J
Hensley, LE
Olinger, G
Smith, DR
AF Reed, Christopher
Lin, Kenny
Wilhelmsen, Catherine
Friedrich, Brian
Nalca, Aysegul
Keeney, Ashley
Donnelly, Ginger
Shamblin, Joshua
Hensley, Lisa E.
Olinger, Gene
Smith, Darci R.
TI Aerosol Exposure to Rift Valley Fever Virus Causes Earlier and More
Severe Neuropathology in the Murine Model, which Has Important
Implications for Therapeutic Development
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID NORTH-AMERICAN MOSQUITOS; INFECTION; RIBAVIRIN; MICE; PATHOGENESIS;
EPIDEMIC; DISEASE; AFRICA; EGYPT
AB Rift Valley fever virus (RVFV) is an important mosquito-borne veterinary and human pathogen that can cause severe disease including acute-onset hepatitis, delayed-onset encephalitis, retinitis and blindness, or a hemorrhagic syndrome. Currently, no licensed vaccine or therapeutics exist to treat this potentially deadly disease. Detailed studies describing the pathogenesis of RVFV following aerosol exposure have not been completed and candidate therapeutics have not been evaluated following an aerosol exposure. These studies are important because while mosquito transmission is the primary means for human infection, it can also be transmitted by aerosol or through mucosal contact. Therefore, we directly compared the pathogenesis of RVFV following aerosol exposure to a subcutaneous (SC) exposure in the murine model by analyzing survival, clinical observations, blood chemistry, hematology, immunohistochemistry, and virus titration of tissues. Additionally, we evaluated the effectiveness of the nucleoside analog ribavirin administered prophylactically to treat mice exposed by aerosol and SC. The route of exposure did not significantly affect the survival, chemistry or hematology results of the mice. Acute hepatitis occurred despite the route of exposure. However, the development of neuropathology occurred much earlier and was more severe in mice exposed by aerosol compared to SC exposed mice. Mice treated with ribavirin and exposed SC were partially protected, whereas treated mice exposed by aerosol were not protected. Early and aggressive viral invasion of brain tissues following aerosol exposure likely played an important role in ribavirin's failure to prevent mortality among these animals. Our results highlight the need for more candidate antivirals to treat RVFV infection, especially in the case of a potential aerosol exposure. Additionally, our study provides an account of the key pathogenetic differences in RVF disease following two potential exposure routes and provides important insights into the development and evaluation of potential vaccines and therapeutics to treat RVFV infection.
C1 [Reed, Christopher; Lin, Kenny; Wilhelmsen, Catherine; Friedrich, Brian; Nalca, Aysegul; Keeney, Ashley; Donnelly, Ginger; Shamblin, Joshua; Hensley, Lisa E.; Olinger, Gene; Smith, Darci R.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
RP Reed, C (reprint author), USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
EM darci.smith@colostate.edu
RI sebastianovitsch, stepan/G-8507-2013;
OI Olinger, Gene/0000-0001-7338-0292
FU Transformational Medical Technologies program from the Department of
Defense Chemical and Biological Defense program through the Defense
Threat Reduction Agency [TMT.DRUG.01.10.RD.002]
FX This work was supported by the Transformational Medical Technologies
program from the Department of Defense Chemical and Biological Defense
program through the Defense Threat Reduction Agency (Project No.
TMT.DRUG.01.10.RD.002). The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
NR 31
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PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1935-2735
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD APR
PY 2013
VL 7
IS 4
AR e2156
DI 10.1371/journal.pntd.0002156
PG 15
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 133QC
UT WOS:000318153100017
PM 23593523
ER
PT J
AU Klapotke, TM
Piercey, DG
Mehta, N
Oyler, KD
Jorgensen, M
Lenahan, S
Salan, JS
Fronabarger, JW
Williams, MD
AF Klapoetke, Thomas M.
Piercey, Davin G.
Mehta, Neha
Oyler, Karl D.
Jorgensen, Matthew
Lenahan, Shannon
Salan, Jerry S.
Fronabarger, John W.
Williams, Michael D.
TI Preparation of High Purity Sodium 5-Nitrotetrazolate (NaNT): An
Essential Precursor to the Environmentally Acceptable Primary Explosive,
DBX-1
SO ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE
LA English
DT Article
DE Tetrazoles; Tetrazines; High energy density materials; Nitrogen-rich
compounds; Energetic materials
ID LEAD AZIDE; REPLACEMENT
AB Sodium 5-nitrotetrazolate dihydrate (NaNT) is a useful precursor compound for the synthesis of lead-free primary explosives; however, currently employed syntheses for the compound are tedious, dangerous, and plagued by impurities. Through comprehensive analysis, we elucidate the identity of the most detrimental impurities and further report an improved procedure for preparation of NaNT, which greatly improves the purity, while avoiding the handling of acid copper(II) nitrotetrazolate, a highly sensitive explosive intermediate. In the new procedure, 5-aminotetrazole is diazotized with sodium nitrite, cupric sulfate, and nitric acid. Copper is precipitated as its oxide and the aqueous solution evaporated. After soxhlet extraction with acetone, large crystals of NaNT are obtained. The prepared material is suitable for preparation of lead azide replacement DBX-1 [copper(I) 5-nitrotetrazolate] as evidenced by successful use in M55 stab detonators.
C1 [Klapoetke, Thomas M.; Piercey, Davin G.] Univ Munich, Dept Chem, D-81377 Munich, Germany.
[Mehta, Neha; Oyler, Karl D.] USA, Explos Dev Branch, RDECOM, ARDEC, Picatinny Arsenal, NJ 07806 USA.
[Jorgensen, Matthew; Lenahan, Shannon; Salan, Jerry S.] Nalas Engn Serv Inc, Centerbrook, CT 06409 USA.
[Fronabarger, John W.; Williams, Michael D.] Pacific Sci Energet Mat Co, Chandler, AZ 85226 USA.
RP Klapotke, TM (reprint author), Univ Munich, Dept Chem, Butenandtstr 5-13 D, D-81377 Munich, Germany.
EM tmk@cup.uni-muenchen.de
RI Klapoetke, Thomas/B-6055-2014
OI Klapoetke, Thomas/0000-0003-3276-1157
FU Ludwig-Maximilian University of Munich (LMU); U.S. Army Research
Laboratory (ARL); RDECOM Ordnance Environmental Program (OEP); Strategic
Environmental Research and Development Program (SERDP); Office of Naval
Research (ONR Global) [W911NF-09-2-0018, W911NF-09-1-0120,
W011NF-09-1-0056, W911NF-12-1-0467, 10 WPSEED01-002 / WP-1765]; Navy
ManTech program
FX Financial support of this work by the Ludwig-Maximilian University of
Munich (LMU), the U.S. Army Research Laboratory (ARL), the RDECOM
Ordnance Environmental Program (OEP), Project Director for Joint
Services (PD-JS), the Strategic Environmental Research and Development
Program (SERDP), and the Office of Naval Research (ONR Global, title:
"Synthesis and Characterization of New High Energy Dense Oxidizers
(HEDO) - NICOP Effort") under contract nos. W911NF-09-2-0018 (ARL),
W911NF-09-1-0120 (ARDEC), W011NF-09-1-0056 (ARDEC), W911NF-12-1-0467,
and 10 WPSEED01-002 / WP-1765 (SERDP) is gratefully acknowledged. The
authors acknowledge collaborations with Dr. Mila Krupka (OZM Research,
Czech Republic) in the development of new testing and evaluation methods
for energetic materials and with Dr. Muhamed Sucesca (Brodarski
Institute, Croatia) in the development of new computational codes to
predict the detonation and propulsion parameters of novel explosives. We
gratefully acknowledge support and guidance given by Steven Gilbert,
Kaitlyn Zienowicz, and John Hirlinger of ARDEC as well as Magdy Bichay
of the U.S. NSWC Indian Head. We are indebted to and thank Drs. Betsy M.
Rice and Brad Forch (ARL, Aberdeen, Proving Ground, MD) and Mr. Gary
Chen (ARDEC, Picatinny Arsenal, NJ) for many helpful and inspired
discussions and support of our work. The authors want to thank St. Huber
for measuring the sensitivities. PSEMC would like to acknowledge Mr.
Chuck Painter and the Navy ManTech program for funding.
NR 18
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U1 1
U2 39
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY
SN 0044-2313
J9 Z ANORG ALLG CHEM
JI Z. Anorg. Allg. Chem.
PD APR
PY 2013
VL 639
IS 5
BP 681
EP 688
DI 10.1002/zaac.201300010
PG 8
WC Chemistry, Inorganic & Nuclear
SC Chemistry
GA 132WJ
UT WOS:000318099100005
ER
PT J
AU Zapata, LE
Portela, G
Suarez, OM
Carrasquillo, O
AF Zapata, L. E.
Portela, G.
Suarez, O. M.
Carrasquillo, O.
TI Rheological performance and compressive strength of superplasticized
cementitious mixtures with microinano-SiO2 additions
SO CONSTRUCTION AND BUILDING MATERIALS
LA English
DT Article
DE Portland cement; Compressive strength; Marsh cone test; Nano-SiO2;
Silica fume
ID SELF-COMPACTING CONCRETE; MECHANICAL-PROPERTIES; MINERAL ADMIXTURES;
SILICA FUME; NANO-SIO2; PASTES; NANOPARTICLES; PARTICLES; FLUIDITY;
MORTAR
AB This study aims to assess the effects of micro and nano-SiO2 under various dosages of carboxylated-polyether-copolymer-type superplasticizer on the rheological properties of grouts in the fresh state. In the hardened state, compressive tests and scanning electron microscopy were used to characterize type I Portland cement mortars. During Stage-I, the rheology of superplasticized grouts (w/b = 0.35 and 0.40) was obtained by the Marsh cone test. Mineral admixtures in superplasticized grouts decrease the flow times and the saturation dosages when compared to the superplasticized-control specimens. In Stage-II, experimental designs at w/b = 0.35 produced flow area, unit weight and air content in mineral admixture-systems better than in superplasticized-control samples. During Stage-III, the maximum strength in the nano-SiO2-system was obtained at 1.0 wt%, whereas in micro-SiO2-systems, this effect occurred at 15 wt%. SEM examinations in the interfacial transition zone suggest that compressive strengths of nano-SiO2-systems were controlled by both densification and filler effects, whereas micro-SiO2-systems were controlled only by the latter. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Zapata, L. E.] Univ Puerto Rico, Dept Civil Engn & Surveying, Mayaguez, PR USA.
[Portela, G.; Suarez, O. M.] Univ Puerto Rico, Dept Engn Sci & Mat, Mayaguez, PR 00708 USA.
[Carrasquillo, O.] USA, Engineer Res & Dev Ctr, Corps Engineers, Vicksburg, MS 39180 USA.
RP Portela, G (reprint author), Univ Puerto Rico, Dept Engn Sci & Mat, Mayaguez, PR 00708 USA.
EM genock.portela@upr.edu
OI Suarez, Oscar/0000-0002-3797-4787
NR 40
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U1 5
U2 39
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0950-0618
J9 CONSTR BUILD MATER
JI Constr. Build. Mater.
PD APR
PY 2013
VL 41
BP 708
EP 716
DI 10.1016/j.conbuildmat.2012.12.025
PG 9
WC Construction & Building Technology; Engineering, Civil; Materials
Science, Multidisciplinary
SC Construction & Building Technology; Engineering; Materials Science
GA 125GS
UT WOS:000317528900078
ER
PT J
AU Govoni, MA
Li, HB
Kosinski, JA
AF Govoni, Mark A.
Li, Hongbin
Kosinski, John A.
TI Low Probability of Interception of an Advanced Noise Radar Waveform with
Linear-FM
SO IEEE TRANSACTIONS ON AEROSPACE AND ELECTRONIC SYSTEMS
LA English
DT Editorial Material
ID SAR; ECCM
AB This research considers an advanced pulse compression noise (APCN) radar waveform possessing salient features from linear-FM (LFM) and noise waveforms. A cross-correlation model considering several chirp waveform profiles is used to simulate the output of a passive electronic intelligence (ELINT) intercept-receiver. By doing so we are able to demonstrate the low probability of interception (LPI) characteristic of the APCN waveform for different kappa values.
C1 [Govoni, Mark A.] USA, CERDEC, Div Radar, Aberdeen Proving Ground, MD 21005 USA.
[Li, Hongbin] Stevens Inst Technol, Hoboken, NJ 07030 USA.
[Kosinski, John A.] Monmouth Univ, W Long Branch, NJ 07764 USA.
[Kosinski, John A.] MacAulay Brown, Dayton, OH 45430 USA.
RP Govoni, MA (reprint author), USA, CERDEC, Div Radar, Aberdeen Proving Ground, MD 21005 USA.
NR 22
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Z9 14
U1 3
U2 22
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-9251
J9 IEEE T AERO ELEC SYS
JI IEEE Trans. Aerosp. Electron. Syst.
PD APR
PY 2013
VL 49
IS 2
BP 1351
EP 1356
PG 6
WC Engineering, Aerospace; Engineering, Electrical & Electronic;
Telecommunications
SC Engineering; Telecommunications
GA 127AY
UT WOS:000317667700046
ER
PT J
AU Farmer, AR
Murray, CK
Mende, K
Akers, KS
Zera, WC
Beckius, ML
Yun, HC
AF Farmer, Aaron R.
Murray, Clinton K.
Mende, Katrin
Akers, Kevin S.
Zera, Wendy C.
Beckius, Miriam L.
Yun, Heather C.
TI Effect of HMG-CoA reductase inhibitors on antimicrobial susceptibilities
for Gram-Negative rods
SO JOURNAL OF BASIC MICROBIOLOGY
LA English
DT Article
DE Antimicrobial susceptibilities; Gram negative rod; HMG-CoA reductase
inhibitors
ID IN-VITRO; STATINS
AB Epidemiologic evidence suggests a beneficial effect of HMG-CoA reductase inhibitors (statins) in sepsis, and in-vitro data exist for antimicrobial activity of statins against some bacteria and fungi. We examined whether statin exposure at physiologic concentrations enhances activity of selected antimicrobials against Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli. Broth microdilution was performed with and without dose-ranging concentrations of lovastatin, fluvastatin, atorvastatin, pravastatin and simvastatin. No effects on antimicrobial activity were demonstrated.
C1 [Farmer, Aaron R.; Murray, Clinton K.; Mende, Katrin; Akers, Kevin S.; Zera, Wendy C.; Yun, Heather C.] San Antonio Mil Med Ctr, Dept Med, Ft Sam Houston, TX USA.
[Murray, Clinton K.; Mende, Katrin; Akers, Kevin S.; Zera, Wendy C.; Yun, Heather C.] San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX USA.
[Murray, Clinton K.; Akers, Kevin S.; Yun, Heather C.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Mende, Katrin; Zera, Wendy C.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
[Beckius, Miriam L.] San Antonio Mil Med Ctr, Dept Clin Invest, Ft Sam Houston, TX USA.
RP Farmer, AR (reprint author), Brooke Army Med Ctr, San Antonio Mil Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM aaron.farmer@amedd.army.mil
RI Valle, Ruben/A-7512-2013
NR 18
TC 5
Z9 5
U1 0
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0233-111X
J9 J BASIC MICROB
JI J. Basic Microbiol.
PD APR
PY 2013
VL 53
IS 4
BP 336
EP 339
DI 10.1002/jobm.201100614
PG 4
WC Microbiology
SC Microbiology
GA 131BO
UT WOS:000317966000006
PM 22736455
ER
EF